locus-tag	class	description
C2H83_RS00010	COG0460	homoserine dehydrogenase
C2H83_RS00010	COG0527	aspartate kinase activity
C2H83_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H83_RS00035	COG1115	amino acid carrier protein
C2H83_RS00040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H83_RS00045	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H83_RS00050	COG1584	GPR1 FUN34 yaaH family protein
C2H83_RS00055	COG4735	regulation of single-species biofilm formation
C2H83_RS00075	COG3385	transposase activity
C2H83_RS00085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2H83_RS00090	COG0583	DNA-binding transcription factor activity
C2H83_RS00115	COG0196	riboflavin kinase activity
C2H83_RS00130	COG1047	Peptidyl-prolyl cis-trans
C2H83_RS00150	COG0505	Belongs to the CarA family
C2H83_RS00155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H83_RS00210	COG0644	oxidoreductase
C2H83_RS00215	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C2H83_RS00220	COG2271	Major facilitator Superfamily
C2H83_RS00235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H83_RS00260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H83_RS00265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2H83_RS00270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2H83_RS00275	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H83_RS00285	COG0564	pseudouridine synthase activity
C2H83_RS00295	COG0417	DNA replication proofreading
C2H83_RS00300	COG0235	Class ii aldolase
C2H83_RS00305	COG2160	L-arabinose isomerase activity
C2H83_RS00310	COG1069	ribulokinase activity
C2H83_RS00320	COG4977	sequence-specific DNA binding
C2H83_RS00325	COG0586	Pfam SNARE associated Golgi protein
C2H83_RS00330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2H83_RS00335	COG1178	ABC-type Fe3 transport system permease component
C2H83_RS00340	COG4143	(ABC) transporter
C2H83_RS00345	COG4533	DNA binding
C2H83_RS00355	COG2814	Major facilitator Superfamily
C2H83_RS00370	COG0473	3-isopropylmalate dehydrogenase activity
C2H83_RS00385	COG0583	DNA-binding transcription factor activity
C2H83_RS00390	COG0028	Belongs to the TPP enzyme family
C2H83_RS00395	COG0440	acetolactate synthase activity
C2H83_RS00405	COG1609	Transcriptional regulator
C2H83_RS00415	COG2001	Belongs to the MraZ family
C2H83_RS00425	COG3116	cell division
C2H83_RS00430	COG0768	penicillin binding
C2H83_RS00435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H83_RS00440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H83_RS00450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H83_RS00455	COG0772	Belongs to the SEDS family
C2H83_RS00470	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H83_RS00475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H83_RS00480	COG0849	cell division
C2H83_RS00485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H83_RS00505	COG0494	nUDIX hydrolase
C2H83_RS00520	COG0237	dephospho-CoA kinase activity
C2H83_RS00530	COG1459	type II secretion system
C2H83_RS00535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H83_RS00540	COG4969	Belongs to the N-Me-Phe pilin family
C2H83_RS00550	COG0157	Belongs to the NadC ModD family
C2H83_RS00555	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2H83_RS00560	COG3725	Membrane protein required for beta-lactamase induction
C2H83_RS00565	COG1113	amino acid transport
C2H83_RS00570	COG2186	Transcriptional regulator
C2H83_RS00580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2H83_RS00585	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H83_RS00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H83_RS00595	COG3064	Membrane
C2H83_RS00605	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2H83_RS00630	COG2132	Multicopper oxidase
C2H83_RS00635	COG4993	Dehydrogenase
C2H83_RS00640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2H83_RS00645	COG0288	reversible hydration of carbon dioxide
C2H83_RS00650	COG1131	(ABC) transporter
C2H83_RS00655	COG0842	Transport permease protein
C2H83_RS00660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS00665	COG0726	polysaccharide deacetylase
C2H83_RS00685	COG5464	transposase or invertase
C2H83_RS00700	COG3539	Fimbrial protein
C2H83_RS00705	COG3539	Fimbrial protein
C2H83_RS00710	COG3539	Fimbrial protein
C2H83_RS00715	COG3539	Fimbrial protein
C2H83_RS00720	COG3188	usher protein
C2H83_RS00725	COG3121	Chaperone
C2H83_RS00730	COG3539	Fimbrial protein
C2H83_RS00735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H83_RS00740	COG0617	tRNA 3'-terminal CCA addition
C2H83_RS00750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H83_RS00760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H83_RS00765	COG1643	Atp-dependent helicase
C2H83_RS00775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H83_RS00780	COG4774	siderophore transport
C2H83_RS00785	COG1120	ATPase activity
C2H83_RS00790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H83_RS00795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H83_RS00815	COG2860	membrane
C2H83_RS00820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H83_RS00840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H83_RS00845	COG3835	regulator
C2H83_RS00855	COG1408	metallophosphoesterase
C2H83_RS00870	COG0024	Methionine aminopeptidase
C2H83_RS00905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2H83_RS00910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H83_RS00915	COG0575	Belongs to the CDS family
C2H83_RS00920	COG0750	zinc metalloprotease
C2H83_RS00930	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2H83_RS00935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2H83_RS00960	COG0587	DNA-directed DNA polymerase activity
C2H83_RS00970	COG1982	Orn Lys Arg decarboxylase major
C2H83_RS00975	COG0346	lactoylglutathione lyase activity
C2H83_RS00980	COG0037	tRNA processing
C2H83_RS00985	COG4568	rho-dependent transcription termination
C2H83_RS00995	COG4681	YaeQ
C2H83_RS01000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2H83_RS01005	COG3015	lipoprotein NlpE involved in copper resistance
C2H83_RS01010	COG0791	NLP P60 protein
C2H83_RS01020	COG1720	tRNA m6t6A37 methyltransferase activity
C2H83_RS01030	COG1464	Belongs to the NlpA lipoprotein family
C2H83_RS01035	COG2011	ABC-type metal ion transport system permease component
C2H83_RS01040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H83_RS01045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2H83_RS01080	COG0656	L-ascorbic acid biosynthetic process
C2H83_RS01085	COG0583	DNA-binding transcription factor activity
C2H83_RS01095	COG2226	methyltransferase
C2H83_RS01100	COG0741	lytic transglycosylase activity
C2H83_RS01100	COG1388	LysM domain
C2H83_RS01110	COG2226	methyltransferase
C2H83_RS01120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H83_RS01155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H83_RS01165	COG1960	acyl-CoA dehydrogenase activity
C2H83_RS01175	COG0121	glutamine amidotransferase
C2H83_RS01180	COG3034	peptidoglycan biosynthetic process
C2H83_RS01185	COG3041	Addiction module toxin RelE StbE family
C2H83_RS01190	COG3077	Addiction module antitoxin, RelB DinJ family
C2H83_RS01195	COG0791	NLP P60 protein
C2H83_RS01200	COG1943	Transposase
C2H83_RS01220	COG2161	toxin-antitoxin pair type II binding
C2H83_RS01230	COG0454	-acetyltransferase
C2H83_RS01235	COG1690	Belongs to the RtcB family
C2H83_RS01240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2H83_RS01245	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H83_RS01265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2H83_RS01300	COG2003	Belongs to the UPF0758 family
C2H83_RS01320	COG2378	regulation of single-species biofilm formation
C2H83_RS01340	COG3596	GTP binding
C2H83_RS01345	COG0583	DNA-binding transcription factor activity
C2H83_RS01355	COG2963	transposase activity
C2H83_RS01360	COG2826	transposase and inactivated derivatives, IS30 family
C2H83_RS01390	COG0833	amino acid
C2H83_RS01395	COG2040	homocysteine
C2H83_RS01400	COG3842	ATPase activity
C2H83_RS01435	COG2801	Transposase and inactivated derivatives
C2H83_RS01435	COG3415	Transposase
C2H83_RS01440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H83_RS01445	COG0129	dihydroxy-acid dehydratase activity
C2H83_RS01450	COG2211	Major facilitator Superfamily
C2H83_RS01455	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H83_RS01460	COG1414	Transcriptional regulator
C2H83_RS01465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H83_RS01490	COG1061	Type III restriction enzyme res subunit
C2H83_RS01500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H83_RS01520	COG0582	viral genome integration into host DNA
C2H83_RS01530	COG0583	DNA-binding transcription factor activity
C2H83_RS01535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H83_RS01540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H83_RS01545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H83_RS01550	COG2080	2 iron, 2 sulfur cluster binding
C2H83_RS01560	COG3477	response to acidic pH
C2H83_RS01570	COG0727	PFAM Uncharacterised protein family (UPF0153)
C2H83_RS01575	COG3121	Chaperone
C2H83_RS01585	COG3188	usher protein
C2H83_RS01640	COG1388	LysM domain
C2H83_RS01655	COG3059	membrane
C2H83_RS01665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H83_RS01670	COG2207	Transcriptional regulator
C2H83_RS01675	COG0247	lactate metabolic process
C2H83_RS01680	COG1139	Iron-sulfur cluster binding protein
C2H83_RS01685	COG1556	Lactate utilization protein
C2H83_RS01725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H83_RS01740	COG2200	EAL domain
C2H83_RS01740	COG2771	luxR family
C2H83_RS01745	COG0583	DNA-binding transcription factor activity
C2H83_RS01760	COG0666	response to abiotic stimulus
C2H83_RS01770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H83_RS01775	COG1304	FMN binding
C2H83_RS01785	COG0549	Belongs to the carbamate kinase family
C2H83_RS01790	COG0402	S-adenosylhomocysteine deaminase activity
C2H83_RS01795	COG1064	alcohol dehydrogenase
C2H83_RS01810	COG1280	lysine exporter protein (LysE YggA)
C2H83_RS01820	COG3829	transcription factor binding
C2H83_RS01825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2H83_RS01830	COG0372	Belongs to the citrate synthase family
C2H83_RS01835	COG2079	MmgE PrpD family protein
C2H83_RS01840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H83_RS01845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H83_RS01850	COG0402	S-adenosylhomocysteine deaminase activity
C2H83_RS01855	COG0583	DNA-binding transcription factor activity
C2H83_RS01860	COG0288	reversible hydration of carbon dioxide
C2H83_RS01870	COG2807	transmembrane transport
C2H83_RS01875	COG0110	maltose O-acetyltransferase activity
C2H83_RS01880	COG2223	nitrite transmembrane transporter activity
C2H83_RS01885	COG3250	beta-galactosidase activity
C2H83_RS01895	COG1609	Transcriptional regulator
C2H83_RS01900	COG1414	Transcriptional regulator
C2H83_RS01920	COG3971	2-oxopent-4-enoate hydratase activity
C2H83_RS01935	COG2814	Major facilitator Superfamily
C2H83_RS01940	COG3122	Protein conserved in bacteria
C2H83_RS01950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C2H83_RS01985	COG1215	transferase activity, transferring glycosyl groups
C2H83_RS01990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H83_RS02000	COG4521	taurine ABC transporter
C2H83_RS02010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H83_RS02015	COG2175	clavaminate synthase activity
C2H83_RS02020	COG0113	porphobilinogen synthase activity
C2H83_RS02030	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS02045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H83_RS02050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H83_RS02060	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C2H83_RS02085	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H83_RS02100	COG1785	Belongs to the alkaline phosphatase family
C2H83_RS02110	COG3706	GGDEF domain
C2H83_RS02115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H83_RS02140	COG4126	flavin adenine dinucleotide binding
C2H83_RS02165	COG1940	carbohydrate kinase activity
C2H83_RS02170	COG2814	Major facilitator Superfamily
C2H83_RS02175	COG0419	ATPase involved in DNA repair
C2H83_RS02180	COG0420	3'-5' exonuclease activity
C2H83_RS02185	COG0745	RESPONSE REGULATOR receiver
C2H83_RS02190	COG5002	protein histidine kinase activity
C2H83_RS02195	COG1114	Component of the transport system for branched-chain amino acids
C2H83_RS02200	COG1113	amino acid transport
C2H83_RS02205	COG0366	Alpha amylase catalytic
C2H83_RS02225	COG1862	Preprotein translocase
C2H83_RS02230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H83_RS02235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H83_RS02240	COG1403	HNH endonuclease
C2H83_RS02245	COG3248	Nucleoside-binding outer membrane protein
C2H83_RS02255	COG4238	major outer membrane lipoprotein
C2H83_RS02265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H83_RS02265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H83_RS02280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2H83_RS02285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H83_RS02290	COG0667	Aldo Keto reductase
C2H83_RS02300	COG0142	geranyltranstransferase activity
C2H83_RS02315	COG0693	protein deglycase activity
C2H83_RS02320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H83_RS02330	COG2814	Major facilitator Superfamily
C2H83_RS02340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H83_RS02345	COG1845	cytochrome c oxidase, subunit III
C2H83_RS02350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H83_RS02355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H83_RS02360	COG2223	nitrite transmembrane transporter activity
C2H83_RS02365	COG3056	Lipoprotein
C2H83_RS02375	COG0271	Belongs to the BolA IbaG family
C2H83_RS02400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H83_RS02405	COG0776	regulation of translation
C2H83_RS02410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H83_RS02415	COG1555	photosystem II stabilization
C2H83_RS02420	COG0824	Thioesterase
C2H83_RS02430	COG4533	DNA binding
C2H83_RS02440	COG1522	sequence-specific DNA binding
C2H83_RS02445	COG1132	(ABC) transporter
C2H83_RS02450	COG1132	(ABC) transporter
C2H83_RS02455	COG0347	Belongs to the P(II) protein family
C2H83_RS02460	COG0004	ammonium transporteR
C2H83_RS02465	COG1946	Acyl-CoA thioesterase
C2H83_RS02470	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C2H83_RS02475	COG3695	enzyme binding
C2H83_RS02485	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2H83_RS02490	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2H83_RS02500	COG0110	maltose O-acetyltransferase activity
C2H83_RS02515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H83_RS02520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS02525	COG1309	transcriptional regulator
C2H83_RS02535	COG3264	Mechanosensitive ion channel
C2H83_RS02535	COG1196	nuclear chromosome segregation
C2H83_RS02545	COG3923	Primosomal replication protein n
C2H83_RS02550	COG2832	Protein of unknown function (DUF454)
C2H83_RS02565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2H83_RS02605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS02610	COG4651	solute:proton antiporter activity
C2H83_RS02610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H83_RS02615	COG2223	nitrite transmembrane transporter activity
C2H83_RS02625	COG0737	Belongs to the 5'-nucleotidase family
C2H83_RS02630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H83_RS02640	COG3735	TraB family
C2H83_RS02650	COG3093	addiction module antidote protein HigA
C2H83_RS02655	COG2217	Heavy metal translocating P-type atpase
C2H83_RS02660	COG2066	Belongs to the glutaminase family
C2H83_RS02665	COG0531	amino acid
C2H83_RS02670	COG0789	Transcriptional regulator
C2H83_RS02675	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H83_RS02680	COG0330	HflC and HflK could
C2H83_RS02685	COG4619	ABC transporter
C2H83_RS02690	COG0390	transport system, permease component
C2H83_RS02695	COG3118	belongs to the thioredoxin family
C2H83_RS02700	COG0300	oxidoreductase activity
C2H83_RS02705	COG2755	lipolytic protein G-D-S-L family
C2H83_RS02710	COG4181	ATPase activity
C2H83_RS02715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2H83_RS02720	COG3209	COG3209 Rhs family protein
C2H83_RS02755	COG0583	DNA-binding transcription factor activity
C2H83_RS02765	COG1414	Transcriptional regulator
C2H83_RS02770	COG3960	tartronate-semialdehyde synthase activity
C2H83_RS02775	COG3622	Belongs to the hyi family
C2H83_RS02780	COG2084	Dehydrogenase
C2H83_RS02785	COG1953	Uracil, thiamine, allantoin
C2H83_RS02795	COG2233	PERMEase
C2H83_RS02800	COG1929	Belongs to the glycerate kinase type-1 family
C2H83_RS02805	COG3257	ureidoglycine aminohydrolase activity
C2H83_RS02810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H83_RS02815	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H83_RS02820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H83_RS02825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H83_RS02830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H83_RS02840	COG0549	Belongs to the carbamate kinase family
C2H83_RS02845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H83_RS02850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H83_RS02865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H83_RS02875	COG1988	membrane-bound metal-dependent
C2H83_RS02880	COG2501	S4 domain
C2H83_RS02890	COG3539	Fimbrial protein
C2H83_RS02895	COG3121	Chaperone
C2H83_RS02900	COG3188	usher protein
C2H83_RS02905	COG3539	Fimbrial protein
C2H83_RS02910	COG3539	Fimbrial protein
C2H83_RS02915	COG2197	response regulator
C2H83_RS02925	COG0582	viral genome integration into host DNA
C2H83_RS02955	COG2076	Multidrug Resistance protein
C2H83_RS02960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H83_RS02965	COG1881	PFAM PEBP family protein
C2H83_RS02970	COG2207	Transcriptional regulator
C2H83_RS03035	COG3772	lysozyme
C2H83_RS03050	COG5562	phage envelope protein
C2H83_RS03075	COG4220	transposase activity
C2H83_RS03090	COG0500	methyltransferase
C2H83_RS03100	COG2207	Transcriptional regulator
C2H83_RS03105	COG4571	Outer membrane protease
C2H83_RS03120	COG2207	Transcriptional regulator
C2H83_RS03135	COG4783	chaperone-mediated protein folding
C2H83_RS03140	COG1215	transferase activity, transferring glycosyl groups
C2H83_RS03145	COG5002	protein histidine kinase activity
C2H83_RS03150	COG0745	RESPONSE REGULATOR receiver
C2H83_RS03160	COG1538	Outer membrane efflux protein
C2H83_RS03165	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS03170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS03175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H83_RS03180	COG1113	amino acid transport
C2H83_RS03185	COG0668	transmembrane transport
C2H83_RS03190	COG0778	Nitroreductase
C2H83_RS03195	COG2315	Protein conserved in bacteria
C2H83_RS03225	COG3385	transposase activity
C2H83_RS03230	COG2977	Belongs to the P-Pant transferase superfamily
C2H83_RS03235	COG4771	TonB-dependent receptor
C2H83_RS03240	COG2382	esterase
C2H83_RS03245	COG3251	PFAM MbtH domain protein
C2H83_RS03250	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H83_RS03250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H83_RS03255	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2H83_RS03260	COG1120	ATPase activity
C2H83_RS03265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H83_RS03270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H83_RS03280	COG4592	Periplasmic binding protein
C2H83_RS03290	COG1169	isochorismate synthase
C2H83_RS03295	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2H83_RS03300	COG1535	isochorismatase
C2H83_RS03300	COG3433	isochorismatase activity
C2H83_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS03310	COG2050	protein possibly involved in aromatic compounds catabolism
C2H83_RS03315	COG1966	Carbon starvation protein
C2H83_RS03320	COG2879	small protein
C2H83_RS03325	COG0371	Dehydrogenase
C2H83_RS03330	COG0436	Aminotransferase
C2H83_RS03335	COG1475	DNA binding
C2H83_RS03340	COG3969	phosphoadenosine phosphosulfate
C2H83_RS03345	COG0583	DNA-binding transcription factor activity
C2H83_RS03355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H83_RS03360	COG0450	alkyl hydroperoxide reductase
C2H83_RS03365	COG3634	alkyl hydroperoxide reductase activity
C2H83_RS03370	COG0589	response to stress
C2H83_RS03375	COG1063	alcohol dehydrogenase
C2H83_RS03385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H83_RS03395	COG3719	Belongs to the RNase T2 family
C2H83_RS03400	COG0471	metal ion transport
C2H83_RS03415	COG3051	citrate lyase alpha subunit
C2H83_RS03420	COG2301	Belongs to the HpcH HpaI aldolase family
C2H83_RS03430	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C2H83_RS03435	COG3290	protein histidine kinase activity
C2H83_RS03440	COG4565	transcriptional regulatory protein
C2H83_RS03445	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H83_RS03475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H83_RS03490	COG0583	DNA-binding transcription factor activity
C2H83_RS03510	COG1686	Belongs to the peptidase S11 family
C2H83_RS03515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H83_RS03520	COG0772	Belongs to the SEDS family
C2H83_RS03525	COG0768	penicillin binding
C2H83_RS03535	COG0799	negative regulation of ribosome biogenesis
C2H83_RS03540	COG0406	alpha-ribazole phosphatase activity
C2H83_RS03550	COG1466	dna polymerase III delta subunit
C2H83_RS03565	COG2888	peptidyl-tyrosine sulfation
C2H83_RS03570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2H83_RS03580	COG2214	Heat shock protein DnaJ domain protein
C2H83_RS03585	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2H83_RS03595	COG2214	Heat shock protein DnaJ domain protein
C2H83_RS03600	COG0443	Heat shock 70 kDa protein
C2H83_RS03610	COG1126	abc transporter atp-binding protein
C2H83_RS03615	COG0765	amino acid transport
C2H83_RS03620	COG0765	amino acid transport
C2H83_RS03625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS03640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2H83_RS03645	COG4535	Mg2 and Co2 transporter CorC
C2H83_RS03655	COG1702	phosphate starvation-inducible protein PhoH
C2H83_RS03665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H83_RS03710	COG0367	asparagine synthase
C2H83_RS03720	COG0647	UMP catabolic process
C2H83_RS03725	COG1846	Transcriptional regulator
C2H83_RS03725	COG1940	carbohydrate kinase activity
C2H83_RS03730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H83_RS03740	COG2190	(PTS) system
C2H83_RS03740	COG1263	PTS System
C2H83_RS03740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS03760	COG0735	belongs to the Fur family
C2H83_RS03770	COG0716	FMN binding
C2H83_RS03780	COG0596	Alpha beta hydrolase
C2H83_RS03785	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2H83_RS03790	COG0033	Phosphoglucomutase
C2H83_RS03810	COG0531	amino acid
C2H83_RS03815	COG1982	Orn Lys Arg decarboxylase major
C2H83_RS03825	COG0745	RESPONSE REGULATOR receiver
C2H83_RS03830	COG2205	protein histidine kinase activity
C2H83_RS03860	COG3209	COG3209 Rhs family protein
C2H83_RS03895	COG3272	Protein of unknown function (DUF1722)
C2H83_RS03900	COG0415	Belongs to the DNA photolyase family
C2H83_RS03905	COG3104	oligopeptide transport
C2H83_RS03910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H83_RS03915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H83_RS03920	COG1984	allophanate hydrolase subunit 2
C2H83_RS03935	COG3180	Ammonia monooxygenase
C2H83_RS03940	COG3539	Fimbrial protein
C2H83_RS03945	COG3121	Chaperone
C2H83_RS03950	COG3188	usher protein
C2H83_RS03955	COG3539	Fimbrial protein
C2H83_RS03960	COG0372	Belongs to the citrate synthase family
C2H83_RS03975	COG2009	succinate dehydrogenase
C2H83_RS03980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2H83_RS03985	COG1053	succinate dehydrogenase
C2H83_RS03990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H83_RS03995	COG0567	Dehydrogenase, E1 component
C2H83_RS04000	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H83_RS04010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H83_RS04015	COG2188	Transcriptional regulator
C2H83_RS04020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS04020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS04020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS04025	COG0383	alpha-mannosidase activity
C2H83_RS04035	COG1271	oxidase subunit
C2H83_RS04040	COG1294	oxidase, subunit
C2H83_RS04045	COG4890	Cyd operon protein YbgT
C2H83_RS04050	COG3790	cyd operon protein YbgE
C2H83_RS04055	COG0824	Thioesterase
C2H83_RS04060	COG0811	peptide transport
C2H83_RS04065	COG0848	biopolymer transport protein
C2H83_RS04070	COG3064	Membrane
C2H83_RS04080	COG2885	chlorophyll binding
C2H83_RS04085	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2H83_RS04135	COG3201	nicotinamide mononucleotide transporter
C2H83_RS04140	COG1230	cation diffusion facilitator family transporter
C2H83_RS04155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2H83_RS04165	COG2017	converts alpha-aldose to the beta-anomer
C2H83_RS04175	COG1085	galactose-1-phosphate uridylyltransferase
C2H83_RS04180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H83_RS04185	COG1119	ATPase activity
C2H83_RS04190	COG2005	Transcriptional regulator
C2H83_RS04190	COG3585	molybdate ion transport
C2H83_RS04205	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H83_RS04210	COG4149	molybdate abc transporter
C2H83_RS04215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2H83_RS04220	COG0561	phosphatase activity
C2H83_RS04230	COG0583	DNA-binding transcription factor activity
C2H83_RS04235	COG2828	Protein conserved in bacteria
C2H83_RS04240	COG0471	metal ion transport
C2H83_RS04245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H83_RS04250	COG4677	pectinesterase activity
C2H83_RS04260	COG1881	PFAM PEBP family protein
C2H83_RS04265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H83_RS04280	COG2226	methyltransferase
C2H83_RS04285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2H83_RS04295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H83_RS04305	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H83_RS04315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2H83_RS04320	COG0314	molybdopterin synthase activity
C2H83_RS04325	COG0670	Belongs to the BI1 family
C2H83_RS04330	COG0670	Belongs to the BI1 family
C2H83_RS04335	COG0392	lysyltransferase activity
C2H83_RS04340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H83_RS04345	COG3568	Endonuclease Exonuclease Phosphatase
C2H83_RS04355	COG0842	Transport permease protein
C2H83_RS04360	COG0842	Transport permease protein
C2H83_RS04365	COG1131	(ABC) transporter
C2H83_RS04375	COG1309	transcriptional regulator
C2H83_RS04380	COG0513	Belongs to the DEAD box helicase family
C2H83_RS04385	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C2H83_RS04395	COG1199	ATP-dependent helicase activity
C2H83_RS04400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H83_RS04405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H83_RS04415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H83_RS04425	COG4774	siderophore transport
C2H83_RS04440	COG0668	transmembrane transport
C2H83_RS04445	COG1126	abc transporter atp-binding protein
C2H83_RS04450	COG0765	amino acid transport
C2H83_RS04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS04480	COG5006	permease, DMT superfamily
C2H83_RS04485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2H83_RS04490	COG2194	sulfuric ester hydrolase activity
C2H83_RS04500	COG1321	iron dependent repressor
C2H83_RS04505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H83_RS04510	COG1376	ErfK ybiS ycfS ynhG family protein
C2H83_RS04515	COG0488	(ABC) transporter
C2H83_RS04525	COG0561	phosphatase activity
C2H83_RS04530	COG1882	Formate acetyltransferase
C2H83_RS04535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2H83_RS04540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H83_RS04545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H83_RS04550	COG0303	'Molybdopterin
C2H83_RS04555	COG1446	asparaginase
C2H83_RS04560	COG4172	Belongs to the ABC transporter superfamily
C2H83_RS04565	COG0747	negative chemotaxis
C2H83_RS04575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H83_RS04580	COG2200	EAL domain
C2H83_RS04585	COG2199	diguanylate cyclase activity
C2H83_RS04600	COG2133	pyrroloquinoline quinone binding
C2H83_RS04605	COG0625	glutathione transferase activity
C2H83_RS04610	COG1686	Belongs to the peptidase S11 family
C2H83_RS04615	COG1349	DNA-binding transcription factor activity
C2H83_RS04620	COG0671	phosphoesterase, PA-phosphatase related
C2H83_RS04625	COG2814	Major facilitator Superfamily
C2H83_RS04635	COG0561	phosphatase activity
C2H83_RS04640	COG0738	Major facilitator superfamily
C2H83_RS04645	COG3226	Transcriptional regulator
C2H83_RS04660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2H83_RS04670	COG0778	Nitroreductase
C2H83_RS04690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2H83_RS04695	COG3842	ATPase activity
C2H83_RS04700	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2H83_RS04705	COG1177	transmembrane transport
C2H83_RS04720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS04725	COG4160	amino acid transport
C2H83_RS04730	COG4215	(ABC) transporter
C2H83_RS04735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS04740	COG1126	abc transporter atp-binding protein
C2H83_RS04755	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2H83_RS04760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H83_RS04765	COG0702	epimerase
C2H83_RS04770	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2H83_RS04775	COG0028	Belongs to the TPP enzyme family
C2H83_RS04780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H83_RS04790	COG2431	L-lysine efflux transmembrane transporter activity
C2H83_RS04805	COG3593	DNA synthesis involved in DNA repair
C2H83_RS04810	COG2990	Protein conserved in bacteria
C2H83_RS04815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS04820	COG0577	efflux transmembrane transporter activity
C2H83_RS04820	COG1136	(ABC) transporter
C2H83_RS04825	COG1278	Cold shock
C2H83_RS04835	COG0542	response to heat
C2H83_RS04855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H83_RS04860	COG4988	ABC transporter
C2H83_RS04865	COG0492	ferredoxin-NADP+ reductase activity
C2H83_RS04875	COG1522	sequence-specific DNA binding
C2H83_RS04880	COG1674	ftsk spoiiie
C2H83_RS04880	COG1178	ABC-type Fe3 transport system permease component
C2H83_RS04890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H83_RS04900	COG0243	molybdopterin cofactor binding
C2H83_RS04905	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS04910	COG3302	dmso reductase anchor subunit
C2H83_RS04915	COG1335	isochorismatase
C2H83_RS04925	COG0531	amino acid
C2H83_RS04930	COG0583	DNA-binding transcription factor activity
C2H83_RS04935	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H83_RS04940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2H83_RS04945	COG1882	Formate acetyltransferase
C2H83_RS04950	COG2116	formate transmembrane transporter activity
C2H83_RS04955	COG1944	ATP diphosphatase activity
C2H83_RS04960	COG2323	membrane
C2H83_RS04975	COG0501	Belongs to the peptidase M48B family
C2H83_RS04985	COG0539	negative regulation of cytoplasmic translation
C2H83_RS04995	COG0658	competence protein
C2H83_RS04995	COG2333	competence protein COMEC
C2H83_RS05000	COG1132	(ABC) transporter
C2H83_RS05005	COG1663	tetraacyldisaccharide 4'-kinase activity
C2H83_RS05010	COG3214	Protein conserved in bacteria
C2H83_RS05025	COG3173	Aminoglycoside phosphotransferase
C2H83_RS05030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2H83_RS05035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H83_RS05045	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2H83_RS05055	COG2989	Protein conserved in bacteria
C2H83_RS05065	COG3108	Peptidase M15
C2H83_RS05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H83_RS05075	COG1448	Aminotransferase
C2H83_RS05095	COG0308	aminopeptidase N
C2H83_RS05100	COG1116	anion transmembrane transporter activity
C2H83_RS05105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H83_RS05115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H83_RS05120	COG0431	NADPH-dependent FMN reductase
C2H83_RS05130	COG3539	Fimbrial protein
C2H83_RS05135	COG3121	Chaperone
C2H83_RS05140	COG3188	usher protein
C2H83_RS05145	COG3539	Fimbrial protein
C2H83_RS05150	COG3539	Fimbrial protein
C2H83_RS05155	COG3539	Fimbrial protein
C2H83_RS05160	COG3121	Chaperone
C2H83_RS05175	COG3217	Mosc domain protein beta barrel domain protein
C2H83_RS05175	COG0633	Ferredoxin
C2H83_RS05185	COG0488	(ABC) transporter
C2H83_RS05190	COG2995	paraquat-inducible protein a
C2H83_RS05195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2H83_RS05195	COG3008	intermembrane lipid transfer
C2H83_RS05200	COG3009	Protein conserved in bacteria
C2H83_RS05205	COG3130	regulation of translation
C2H83_RS05215	COG1067	ATP-dependent peptidase activity
C2H83_RS05225	COG2885	chlorophyll binding
C2H83_RS05225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2H83_RS05240	COG3070	regulator of competence-specific genes
C2H83_RS05245	COG1289	transmembrane transporter activity
C2H83_RS05250	COG3304	Inner membrane component domain
C2H83_RS05255	COG0210	DNA helicase
C2H83_RS05270	COG1832	CoA-binding protein
C2H83_RS05285	COG1254	Belongs to the acylphosphatase family
C2H83_RS05290	COG2920	part of a sulfur-relay system
C2H83_RS05295	COG0670	Belongs to the BI1 family
C2H83_RS05305	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2H83_RS05310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2H83_RS05315	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C2H83_RS05320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H83_RS05325	COG1999	signal sequence binding
C2H83_RS05330	COG1773	rubredoxin
C2H83_RS05335	COG1271	oxidase subunit
C2H83_RS05340	COG1294	oxidase, subunit
C2H83_RS05355	COG3206	protein involved in exopolysaccharide biosynthesis
C2H83_RS05355	COG0489	protein tyrosine kinase activity
C2H83_RS05360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H83_RS05365	COG1596	polysaccharide export
C2H83_RS05370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H83_RS05400	COG1278	Cold shock
C2H83_RS05405	COG1278	Cold shock
C2H83_RS05425	COG0348	domain, Protein
C2H83_RS05430	COG2198	Histidine kinase
C2H83_RS05430	COG0784	Response regulator, receiver
C2H83_RS05430	COG2205	protein histidine kinase activity
C2H83_RS05435	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS05440	COG0745	RESPONSE REGULATOR receiver
C2H83_RS05445	COG3005	denitrification pathway
C2H83_RS05450	COG0243	molybdopterin cofactor binding
C2H83_RS05455	COG3381	protein complex oligomerization
C2H83_RS05495	COG3729	General stress protein
C2H83_RS05500	COG2233	PERMEase
C2H83_RS05535	COG1309	transcriptional regulator
C2H83_RS05540	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2H83_RS05540	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2H83_RS05540	COG0506	proline dehydrogenase activity
C2H83_RS05555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H83_RS05580	COG2822	iron ion transport
C2H83_RS05585	COG2837	iron assimilation
C2H83_RS05590	COG1702	phosphate starvation-inducible protein PhoH
C2H83_RS05595	COG3658	cytochrome
C2H83_RS05600	COG1215	transferase activity, transferring glycosyl groups
C2H83_RS05605	COG1649	PFAM Uncharacterised BCR, COG1649
C2H83_RS05605	COG0726	polysaccharide deacetylase
C2H83_RS05610	COG0457	Tetratricopeptide repeat
C2H83_RS05615	COG3706	GGDEF domain
C2H83_RS05660	COG3381	protein complex oligomerization
C2H83_RS05670	COG1462	curli production assembly transport component CsgG
C2H83_RS05685	COG2197	response regulator
C2H83_RS05720	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2H83_RS05725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H83_RS05750	COG2943	transferase activity, transferring hexosyl groups
C2H83_RS05755	COG5645	(Lipo)protein
C2H83_RS05770	COG1560	Kdo2-lipid A biosynthetic process
C2H83_RS05780	COG2353	YceI-like domain
C2H83_RS05785	COG3038	cytochrome b561
C2H83_RS05825	COG2999	glutathione oxidoreductase activity
C2H83_RS05835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H83_RS05845	COG0673	inositol 2-dehydrogenase activity
C2H83_RS05850	COG0728	peptidoglycan biosynthetic process
C2H83_RS05855	COG3418	PFAM FlgN family protein
C2H83_RS05860	COG2747	anti-sigma28 factor FlgM
C2H83_RS05865	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2H83_RS05870	COG1815	bacterial-type flagellum-dependent cell motility
C2H83_RS05875	COG1558	bacterial-type flagellum-dependent cell motility
C2H83_RS05880	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H83_RS05885	COG1749	Flagellar hook protein flgE
C2H83_RS05890	COG4787	bacterial-type flagellum-dependent cell motility
C2H83_RS05895	COG4786	Flagellar basal body rod
C2H83_RS05910	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2H83_RS05910	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H83_RS05915	COG1256	bacterial-type flagellum assembly
C2H83_RS05920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H83_RS05925	COG1530	ribonuclease E activity
C2H83_RS05935	COG0564	pseudouridine synthase activity
C2H83_RS05940	COG0424	maF-like protein
C2H83_RS05945	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H83_RS05965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H83_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS05980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H83_RS05985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H83_RS05990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H83_RS06000	COG0470	DNA polymerase III
C2H83_RS06005	COG0084	hydrolase, TatD family'
C2H83_RS06010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS06010	COG1263	PTS System
C2H83_RS06015	COG4773	Receptor
C2H83_RS06020	COG0537	adenosine 5'-monophosphoramidase activity
C2H83_RS06025	COG5633	Lipoprotein
C2H83_RS06030	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C2H83_RS06050	COG1252	NADH dehydrogenase
C2H83_RS06055	COG3134	Outer membrane lipoprotein
C2H83_RS06060	COG1309	transcriptional regulator
C2H83_RS06070	COG1376	ErfK ybiS ycfS ynhG family protein
C2H83_RS06070	COG1388	LysM domain
C2H83_RS06075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H83_RS06080	COG4763	Acyl-transferase
C2H83_RS06085	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2H83_RS06090	COG1136	(ABC) transporter
C2H83_RS06095	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2H83_RS06105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H83_RS06110	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H83_RS06120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2H83_RS06125	COG1177	transmembrane transport
C2H83_RS06135	COG3842	ATPase activity
C2H83_RS06150	COG2850	peptidyl-arginine hydroxylation
C2H83_RS06155	COG2205	protein histidine kinase activity
C2H83_RS06160	COG0745	RESPONSE REGULATOR receiver
C2H83_RS06165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H83_RS06185	COG1187	pseudouridine synthase activity
C2H83_RS06190	COG0538	isocitrate dehydrogenase activity
C2H83_RS06195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H83_RS06210	COG0582	viral genome integration into host DNA
C2H83_RS06240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H83_RS06245	COG4197	protein conserved in bacteria, prophage-related
C2H83_RS06260	COG1802	Transcriptional regulator
C2H83_RS06260	COG4626	Terminase
C2H83_RS06270	COG4695	Portal protein
C2H83_RS06275	COG3299	homolog of phage Mu protein gp47
C2H83_RS06280	COG3778	Protein conserved in bacteria
C2H83_RS06295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2H83_RS06305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H83_RS06310	COG1403	HNH endonuclease
C2H83_RS06315	COG0538	isocitrate dehydrogenase activity
C2H83_RS06325	COG5562	phage envelope protein
C2H83_RS06330	COG0789	Transcriptional regulator
C2H83_RS06335	COG2200	EAL domain
C2H83_RS06360	COG2200	EAL domain
C2H83_RS06420	COG2894	cell division
C2H83_RS06450	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H83_RS06465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H83_RS06470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H83_RS06475	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H83_RS06490	COG2719	SpoVR family
C2H83_RS06500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H83_RS06515	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H83_RS06530	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2H83_RS06535	COG2261	transglycosylase associated protein
C2H83_RS06555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS06555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H83_RS06555	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C2H83_RS06560	COG1461	Dihydroxyacetone kinase
C2H83_RS06565	COG2376	Dihydroxyacetone kinase
C2H83_RS06570	COG3284	Transcriptional regulator
C2H83_RS06575	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS06590	COG0012	GTP binding
C2H83_RS06605	COG0659	secondary active sulfate transmembrane transporter activity
C2H83_RS06615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H83_RS06645	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H83_RS06650	COG3094	Invasion gene expression up-regulator, SirB
C2H83_RS06655	COG2912	Transglutaminase-like superfamily
C2H83_RS06685	COG0387	Pfam Sodium calcium exchanger
C2H83_RS06690	COG4572	Cation transport regulator
C2H83_RS06695	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2H83_RS06700	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2H83_RS06705	COG4932	domain protein
C2H83_RS06710	COG2197	response regulator
C2H83_RS06715	COG3850	Histidine kinase
C2H83_RS06725	COG2223	nitrite transmembrane transporter activity
C2H83_RS06730	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H83_RS06735	COG1140	nitrate reductase beta subunit
C2H83_RS06740	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H83_RS06745	COG2181	nitrate reductase activity
C2H83_RS06780	COG0788	formyltetrahydrofolate deformylase activity
C2H83_RS06790	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H83_RS06795	COG0745	RESPONSE REGULATOR receiver
C2H83_RS06800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H83_RS06810	COG1435	thymidine kinase activity
C2H83_RS06820	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS06820	COG1454	alcohol dehydrogenase
C2H83_RS06825	COG2095	MarC family integral membrane protein
C2H83_RS06835	COG4166	transmembrane transport
C2H83_RS06840	COG0601	transmembrane transport
C2H83_RS06845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H83_RS06850	COG0444	Belongs to the ABC transporter superfamily
C2H83_RS06855	COG4608	Belongs to the ABC transporter superfamily
C2H83_RS06875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H83_RS06880	COG2350	Protein conserved in bacteria
C2H83_RS06885	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2H83_RS06890	COG1607	acyl-coa hydrolase
C2H83_RS06910	COG3047	cAMP biosynthetic process
C2H83_RS06915	COG3685	Protein conserved in bacteria
C2H83_RS06920	COG3685	Protein conserved in bacteria
C2H83_RS06925	COG3729	General stress protein
C2H83_RS06940	COG0135	phosphoribosylanthranilate isomerase activity
C2H83_RS06940	COG0134	indole-3-glycerol-phosphate synthase activity
C2H83_RS06945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H83_RS06945	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H83_RS06950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H83_RS06960	COG0613	PHP domain protein
C2H83_RS06965	COG0009	L-threonylcarbamoyladenylate synthase
C2H83_RS06970	COG4907	membrane protein (DUF2207)
C2H83_RS06975	COG1187	pseudouridine synthase activity
C2H83_RS06980	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C2H83_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS06990	COG0616	signal peptide processing
C2H83_RS07005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H83_RS07015	COG0583	DNA-binding transcription factor activity
C2H83_RS07035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H83_RS07045	COG0671	phosphoesterase, PA-phosphatase related
C2H83_RS07050	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C2H83_RS07055	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2H83_RS07065	COG0023	Translation Initiation Factor
C2H83_RS07075	COG1349	DNA-binding transcription factor activity
C2H83_RS07085	COG5001	Diguanylate cyclase
C2H83_RS07100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H83_RS07100	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H83_RS07105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H83_RS07110	COG2852	Protein conserved in bacteria
C2H83_RS07115	COG4172	Belongs to the ABC transporter superfamily
C2H83_RS07120	COG4172	Belongs to the ABC transporter superfamily
C2H83_RS07125	COG4171	peptide transport system, permease
C2H83_RS07130	COG4168	peptide transport system, permease
C2H83_RS07135	COG4166	transmembrane transport
C2H83_RS07150	COG0531	amino acid
C2H83_RS07155	COG0174	glutamine synthetase
C2H83_RS07160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2H83_RS07165	COG1396	sequence-specific DNA binding
C2H83_RS07165	COG1917	Cupin 2, conserved barrel domain protein
C2H83_RS07175	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS07180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H83_RS07185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H83_RS07190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H83_RS07195	COG1842	Phage shock protein A
C2H83_RS07205	COG1983	PspC domain protein
C2H83_RS07215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H83_RS07220	COG0366	Alpha amylase catalytic
C2H83_RS07225	COG1653	transport
C2H83_RS07230	COG1175	transmembrane transport
C2H83_RS07235	COG0395	ABC-type sugar transport system, permease component
C2H83_RS07240	COG1063	alcohol dehydrogenase
C2H83_RS07245	COG1082	Xylose isomerase domain protein TIM barrel
C2H83_RS07250	COG0673	inositol 2-dehydrogenase activity
C2H83_RS07255	COG1554	hydrolase, family 65, central catalytic
C2H83_RS07260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H83_RS07275	COG1609	Transcriptional regulator
C2H83_RS07280	COG3106	COG3106 Predicted ATPase
C2H83_RS07290	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C2H83_RS07295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H83_RS07300	COG4948	Mandelate Racemase Muconate Lactonizing
C2H83_RS07305	COG2866	Carboxypeptidase
C2H83_RS07310	COG0702	epimerase
C2H83_RS07315	COG1073	alpha beta
C2H83_RS07320	COG0583	DNA-binding transcription factor activity
C2H83_RS07325	COG4166	transmembrane transport
C2H83_RS07330	COG0668	transmembrane transport
C2H83_RS07340	COG3182	Iron-regulated membrane protein
C2H83_RS07345	COG0589	response to stress
C2H83_RS07350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H83_RS07355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H83_RS07360	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2H83_RS07370	COG1473	amidohydrolase
C2H83_RS07375	COG1473	amidohydrolase
C2H83_RS07380	COG0583	DNA-binding transcription factor activity
C2H83_RS07390	COG2840	Smr protein MutS2
C2H83_RS07395	COG3706	GGDEF domain
C2H83_RS07410	COG0513	Belongs to the DEAD box helicase family
C2H83_RS07420	COG0582	viral genome integration into host DNA
C2H83_RS07440	COG3723	Recombinational DNA repair protein, rece pathway
C2H83_RS07445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H83_RS07490	COG4197	protein conserved in bacteria, prophage-related
C2H83_RS07500	COG3756	Protein conserved in bacteria
C2H83_RS07505	COG1484	DNA-dependent DNA replication
C2H83_RS07520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H83_RS07530	COG1475	DNA binding
C2H83_RS07560	COG3039	Transposase
C2H83_RS07570	COG5301	cellulose 1,4-beta-cellobiosidase activity
C2H83_RS07575	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2H83_RS07580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H83_RS07590	COG0589	response to stress
C2H83_RS07595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2H83_RS07605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2H83_RS07605	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2H83_RS07605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2H83_RS07605	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2H83_RS07610	COG3042	response to heat
C2H83_RS07615	COG3187	Heat shock protein
C2H83_RS07620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H83_RS07625	COG2911	Protein conserved in bacteria
C2H83_RS07635	COG3784	Protein of unknown function (DUF1318)
C2H83_RS07640	COG2207	Transcriptional regulator
C2H83_RS07645	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS07650	COG3733	amine oxidase
C2H83_RS07655	COG2030	dehydratase
C2H83_RS07655	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS07660	COG3396	Phenylacetate-CoA oxygenase
C2H83_RS07665	COG3460	Phenylacetate-CoA oxygenase
C2H83_RS07670	COG3396	Phenylacetate-CoA oxygenase
C2H83_RS07675	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H83_RS07680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H83_RS07685	COG1024	Enoyl-CoA hydratase
C2H83_RS07690	COG1024	Enoyl-CoA hydratase
C2H83_RS07695	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H83_RS07700	COG2050	protein possibly involved in aromatic compounds catabolism
C2H83_RS07705	COG0183	Belongs to the thiolase family
C2H83_RS07710	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2H83_RS07715	COG3327	negative regulation of DNA-templated transcription, initiation
C2H83_RS07720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H83_RS07740	COG2826	transposase and inactivated derivatives, IS30 family
C2H83_RS07755	COG0667	Aldo Keto reductase
C2H83_RS07765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H83_RS07770	COG4589	Belongs to the CDS family
C2H83_RS07775	COG2267	carboxylic ester hydrolase activity
C2H83_RS07780	COG2453	phosphatase
C2H83_RS07780	COG0671	phosphoesterase, PA-phosphatase related
C2H83_RS07790	COG1643	Atp-dependent helicase
C2H83_RS07795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2H83_RS07800	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS07815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H83_RS07820	COG3038	cytochrome b561
C2H83_RS07835	COG0840	transmembrane signaling receptor activity
C2H83_RS07840	COG0583	DNA-binding transcription factor activity
C2H83_RS07845	COG5383	Protein conserved in bacteria
C2H83_RS07865	COG2841	Protein conserved in bacteria
C2H83_RS07870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H83_RS07875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H83_RS07880	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2H83_RS07885	COG0500	methyltransferase
C2H83_RS07900	COG0675	Transposase, IS605 OrfB family
C2H83_RS07905	COG3135	benzoate transporter
C2H83_RS07910	COG1396	sequence-specific DNA binding
C2H83_RS07915	COG0826	peptidase U32
C2H83_RS07925	COG1724	mRNA binding
C2H83_RS07930	COG1598	PFAM Uncharacterised protein family UPF0150
C2H83_RS07935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H83_RS07940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2H83_RS07945	COG3842	ATPase activity
C2H83_RS07950	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2H83_RS07955	COG1177	transmembrane transport
C2H83_RS07985	COG3238	Protein conserved in bacteria
C2H83_RS07990	COG1247	-acetyltransferase
C2H83_RS08000	COG2130	NADP-dependent
C2H83_RS08005	COG1802	Transcriptional regulator
C2H83_RS08010	COG4772	TonB-dependent receptor
C2H83_RS08025	COG3391	amine dehydrogenase activity
C2H83_RS08030	COG1113	amino acid transport
C2H83_RS08035	COG0625	glutathione transferase activity
C2H83_RS08050	COG3209	COG3209 Rhs family protein
C2H83_RS08065	COG5433	transposase activity
C2H83_RS08075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H83_RS08080	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2H83_RS08085	COG0384	phenazine biosynthesis protein PhzF
C2H83_RS08090	COG2181	nitrate reductase activity
C2H83_RS08095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H83_RS08100	COG1140	nitrate reductase beta subunit
C2H83_RS08105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H83_RS08110	COG2223	nitrite transmembrane transporter activity
C2H83_RS08120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2H83_RS08125	COG0697	spore germination
C2H83_RS08130	COG0243	molybdopterin cofactor binding
C2H83_RS08130	COG3383	formate dehydrogenase (NAD+) activity
C2H83_RS08135	COG0243	molybdopterin cofactor binding
C2H83_RS08135	COG3383	formate dehydrogenase (NAD+) activity
C2H83_RS08140	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS08145	COG2864	formate dehydrogenase
C2H83_RS08150	COG3093	addiction module antidote protein HigA
C2H83_RS08155	COG1064	alcohol dehydrogenase
C2H83_RS08180	COG1764	response to oxidative stress
C2H83_RS08185	COG4608	Belongs to the ABC transporter superfamily
C2H83_RS08190	COG0444	Belongs to the ABC transporter superfamily
C2H83_RS08195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H83_RS08200	COG0601	transmembrane transport
C2H83_RS08205	COG0747	negative chemotaxis
C2H83_RS08210	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C2H83_RS08215	COG2200	EAL domain
C2H83_RS08215	COG2202	Pas domain
C2H83_RS08215	COG2199	diguanylate cyclase activity
C2H83_RS08220	COG3706	GGDEF domain
C2H83_RS08225	COG1649	PFAM Uncharacterised BCR, COG1649
C2H83_RS08230	COG0531	amino acid
C2H83_RS08235	COG0076	glutamate decarboxylase activity
C2H83_RS08240	COG0612	Peptidase, M16
C2H83_RS08245	COG4771	TonB-dependent receptor
C2H83_RS08250	COG4178	(ABC) transporter
C2H83_RS08255	COG0641	radical SAM
C2H83_RS08260	COG3119	arylsulfatase activity
C2H83_RS08265	COG2207	Transcriptional regulator
C2H83_RS08275	COG0243	molybdopterin cofactor binding
C2H83_RS08280	COG3539	Fimbrial protein
C2H83_RS08285	COG3539	Fimbrial protein
C2H83_RS08290	COG3539	Fimbrial protein
C2H83_RS08310	COG3550	peptidyl-serine autophosphorylation
C2H83_RS08315	COG1396	sequence-specific DNA binding
C2H83_RS08325	COG2911	Protein conserved in bacteria
C2H83_RS08325	COG3210	domain, Protein
C2H83_RS08375	COG3781	membrane
C2H83_RS08395	COG2199	diguanylate cyclase activity
C2H83_RS08405	COG2066	Belongs to the glutaminase family
C2H83_RS08410	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS08415	COG0583	DNA-binding transcription factor activity
C2H83_RS08440	COG4977	sequence-specific DNA binding
C2H83_RS08450	COG0697	spore germination
C2H83_RS08455	COG2814	Major facilitator Superfamily
C2H83_RS08465	COG3706	GGDEF domain
C2H83_RS08470	COG3111	PFAM Bacterial OB fold (BOF) protein
C2H83_RS08475	COG1546	Belongs to the CinA family
C2H83_RS08480	COG0339	signal peptide processing
C2H83_RS08485	COG4221	oxidoreductase activity
C2H83_RS08490	COG1802	Transcriptional regulator
C2H83_RS08500	COG0246	Mannitol dehydrogenase
C2H83_RS08505	COG0477	Major facilitator Superfamily
C2H83_RS08515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H83_RS08520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2H83_RS08525	COG5301	cellulose 1,4-beta-cellobiosidase activity
C2H83_RS08530	COG4220	transposase activity
C2H83_RS08545	COG5562	phage envelope protein
C2H83_RS08565	COG1278	Cold shock
C2H83_RS08575	COG3772	lysozyme
C2H83_RS08590	COG1278	Cold shock
C2H83_RS08595	COG1278	Cold shock
C2H83_RS08600	COG0484	heat shock protein binding
C2H83_RS08605	COG1403	HNH endonuclease
C2H83_RS08625	COG2026	Addiction module toxin, RelE StbE family
C2H83_RS08630	COG3077	Addiction module antitoxin, RelB DinJ family
C2H83_RS08660	COG1396	sequence-specific DNA binding
C2H83_RS08705	COG0582	viral genome integration into host DNA
C2H83_RS08715	COG1063	alcohol dehydrogenase
C2H83_RS08720	COG4948	Mandelate Racemase Muconate Lactonizing
C2H83_RS08740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H83_RS08755	COG0243	molybdopterin cofactor binding
C2H83_RS08760	COG0243	molybdopterin cofactor binding
C2H83_RS08765	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS08770	COG3302	dmso reductase anchor subunit
C2H83_RS08775	COG3381	protein complex oligomerization
C2H83_RS08785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2H83_RS08790	COG1940	carbohydrate kinase activity
C2H83_RS08795	COG0583	DNA-binding transcription factor activity
C2H83_RS08800	COG2814	Major facilitator Superfamily
C2H83_RS08820	COG3591	Belongs to the peptidase S1B family
C2H83_RS08840	COG0628	permease
C2H83_RS08845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2H83_RS08850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2H83_RS08865	COG0531	amino acid
C2H83_RS08875	COG3136	membrane protein required for alginate biosynthesis
C2H83_RS08880	COG0745	RESPONSE REGULATOR receiver
C2H83_RS08885	COG2205	protein histidine kinase activity
C2H83_RS08895	COG0114	fumarate hydratase activity
C2H83_RS08900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2H83_RS08900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2H83_RS08905	COG1482	cell wall glycoprotein biosynthetic process
C2H83_RS08910	COG5339	Protein conserved in bacteria
C2H83_RS08920	COG2211	Major facilitator Superfamily
C2H83_RS08925	COG3250	beta-galactosidase activity
C2H83_RS08930	COG1309	transcriptional regulator
C2H83_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS08940	COG1609	Transcriptional regulator
C2H83_RS08945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS08945	COG1263	PTS System
C2H83_RS08950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H83_RS08960	COG0673	inositol 2-dehydrogenase activity
C2H83_RS09005	COG4659	FMN binding
C2H83_RS09015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H83_RS09025	COG3104	oligopeptide transport
C2H83_RS09030	COG0625	glutathione transferase activity
C2H83_RS09035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2H83_RS09050	COG3895	Periplasmic Protein
C2H83_RS09060	COG3133	Outer membrane lipoprotein
C2H83_RS09075	COG1566	PFAM secretion protein HlyD family protein
C2H83_RS09080	COG1289	transmembrane transporter activity
C2H83_RS09085	COG2032	superoxide dismutase activity
C2H83_RS09090	COG4989	oxidoreductase activity
C2H83_RS09095	COG3313	Fe-S protein
C2H83_RS09100	COG1309	transcriptional regulator
C2H83_RS09105	COG1902	pentaerythritol trinitrate reductase activity
C2H83_RS09110	COG0346	lactoylglutathione lyase activity
C2H83_RS09115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H83_RS09120	COG1201	RNA secondary structure unwinding
C2H83_RS09125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2H83_RS09130	COG0791	NLP P60 protein
C2H83_RS09135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H83_RS09140	COG2814	Major facilitator Superfamily
C2H83_RS09160	COG0583	DNA-binding transcription factor activity
C2H83_RS09165	COG2814	Major facilitator Superfamily
C2H83_RS09170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2H83_RS09175	COG0307	riboflavin synthase, alpha
C2H83_RS09185	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS09205	COG4529	Protein conserved in bacteria
C2H83_RS09215	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C2H83_RS09220	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS09230	COG2414	aldehyde ferredoxin oxidoreductase
C2H83_RS09235	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS09245	COG0469	pyruvate kinase activity
C2H83_RS09250	COG4238	major outer membrane lipoprotein
C2H83_RS09255	COG1376	ErfK ybiS ycfS ynhG family protein
C2H83_RS09270	COG0719	Fe-S assembly protein
C2H83_RS09275	COG0396	ATPase activity
C2H83_RS09280	COG0719	Fe-S assembly protein
C2H83_RS09285	COG0316	Belongs to the HesB IscA family
C2H83_RS09295	COG2050	protein possibly involved in aromatic compounds catabolism
C2H83_RS09300	COG0277	FAD linked oxidase domain protein
C2H83_RS09300	COG0247	lactate metabolic process
C2H83_RS09310	COG0628	permease
C2H83_RS09325	COG0738	Major facilitator superfamily
C2H83_RS09330	COG2271	Major facilitator Superfamily
C2H83_RS09345	COG4670	ketone body catabolic process
C2H83_RS09350	COG1960	acyl-CoA dehydrogenase activity
C2H83_RS09355	COG1917	Cupin 2, conserved barrel domain protein
C2H83_RS09355	COG2207	Transcriptional regulator
C2H83_RS09365	COG2086	electron transfer activity
C2H83_RS09370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H83_RS09375	COG0644	oxidoreductase
C2H83_RS09380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C2H83_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
C2H83_RS09390	COG0574	Belongs to the PEP-utilizing enzyme family
C2H83_RS09390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H83_RS09405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2H83_RS09410	COG4256	Hemin uptake protein
C2H83_RS09420	COG2200	EAL domain
C2H83_RS09425	COG0791	NLP P60 protein
C2H83_RS09435	COG0386	Belongs to the glutathione peroxidase family
C2H83_RS09450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H83_RS09450	COG0072	phenylalanine-tRNA ligase activity
C2H83_RS09500	COG3137	Salt-induced outer membrane protein
C2H83_RS09505	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H83_RS09515	COG3001	Fructosamine kinase
C2H83_RS09525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H83_RS09530	COG1988	membrane-bound metal-dependent
C2H83_RS09535	COG1823	symporter activity
C2H83_RS09550	COG0753	catalase activity
C2H83_RS09560	COG1486	melibiose metabolic process
C2H83_RS09565	COG1917	Cupin 2, conserved barrel domain protein
C2H83_RS09565	COG2169	Transcriptional regulator
C2H83_RS09570	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H83_RS09575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H83_RS09580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H83_RS09590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H83_RS09600	COG0322	excinuclease ABC activity
C2H83_RS09610	COG3678	ATP-independent chaperone mediated protein folding
C2H83_RS09645	COG0708	Exodeoxyribonuclease III
C2H83_RS09650	COG0398	Pfam SNARE associated Golgi protein
C2H83_RS09660	COG0398	Pfam SNARE associated Golgi protein
C2H83_RS09665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H83_RS09670	COG4134	Bacterial extracellular solute-binding protein
C2H83_RS09675	COG4135	transport system, permease component
C2H83_RS09680	COG4136	ATPase activity
C2H83_RS09685	COG2897	thiosulfate sulfurtransferase activity
C2H83_RS09690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H83_RS09695	COG0494	nUDIX hydrolase
C2H83_RS09705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H83_RS09715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H83_RS09730	COG0778	Nitroreductase
C2H83_RS09740	COG0616	signal peptide processing
C2H83_RS09745	COG0252	asparaginase activity
C2H83_RS09750	COG1335	isochorismatase
C2H83_RS09755	COG2814	Major facilitator Superfamily
C2H83_RS09760	COG1349	DNA-binding transcription factor activity
C2H83_RS09765	COG0667	Aldo Keto reductase
C2H83_RS09770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS09775	COG0191	fructose-bisphosphate aldolase activity
C2H83_RS09780	COG1063	alcohol dehydrogenase
C2H83_RS09785	COG2271	Major facilitator Superfamily
C2H83_RS09790	COG1063	alcohol dehydrogenase
C2H83_RS09795	COG3139	Protein of unknown function (DUF1315)
C2H83_RS09805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H83_RS09810	COG0676	glucose-6-phosphate 1-epimerase activity
C2H83_RS09815	COG0656	L-ascorbic acid biosynthetic process
C2H83_RS09820	COG3713	MltA-interacting MipA family protein
C2H83_RS09825	COG2766	serine protein kinase
C2H83_RS09835	COG2199	diguanylate cyclase activity
C2H83_RS09840	COG2199	diguanylate cyclase activity
C2H83_RS09845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H83_RS09860	COG2207	Transcriptional regulator
C2H83_RS09865	COG2807	transmembrane transport
C2H83_RS09870	COG3189	MarR family transcriptional regulator
C2H83_RS09875	COG3042	response to heat
C2H83_RS09880	COG2203	Gaf domain
C2H83_RS09880	COG2199	diguanylate cyclase activity
C2H83_RS09895	COG2261	transglycosylase associated protein
C2H83_RS09905	COG3615	Tellurite resistance protein tehB
C2H83_RS09915	COG0583	DNA-binding transcription factor activity
C2H83_RS09920	COG0473	3-isopropylmalate dehydrogenase activity
C2H83_RS09925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H83_RS09930	COG4638	Rieske (2fe-2S)
C2H83_RS09935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H83_RS09940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2H83_RS09945	COG0318	PFAM AMP-dependent synthetase and ligase
C2H83_RS09950	COG3065	identical protein binding
C2H83_RS09955	COG1214	PFAM Peptidase M22, glycoprotease
C2H83_RS09960	COG1199	ATP-dependent helicase activity
C2H83_RS09965	COG0251	oxidation-reduction process
C2H83_RS09980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H83_RS09990	COG1760	l-serine dehydratase
C2H83_RS09995	COG2200	EAL domain
C2H83_RS10000	COG1253	flavin adenine dinucleotide binding
C2H83_RS10015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS10015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS10020	COG3715	PTS system
C2H83_RS10025	COG3716	PTS system mannose fructose sorbose family IID component
C2H83_RS10045	COG2226	methyltransferase
C2H83_RS10080	COG1414	Transcriptional regulator
C2H83_RS10085	COG2814	Major facilitator Superfamily
C2H83_RS10095	COG0793	Belongs to the peptidase S41A family
C2H83_RS10105	COG1956	GAF domain-containing protein
C2H83_RS10110	COG2995	paraquat-inducible protein a
C2H83_RS10115	COG3008	intermembrane lipid transfer
C2H83_RS10135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H83_RS10145	COG1276	copper resistance
C2H83_RS10150	COG2372	response to copper ion
C2H83_RS10160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H83_RS10165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H83_RS10170	COG1770	oligopeptidase
C2H83_RS10175	COG2979	Protein of unknown function (DUF533)
C2H83_RS10185	COG3141	response to X-ray
C2H83_RS10195	COG0800	Aldolase
C2H83_RS10200	COG0129	dihydroxy-acid dehydratase activity
C2H83_RS10205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H83_RS10210	COG1737	Transcriptional regulator
C2H83_RS10215	COG0469	pyruvate kinase activity
C2H83_RS10220	COG1560	Kdo2-lipid A biosynthetic process
C2H83_RS10225	COG0739	heme binding
C2H83_RS10230	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2H83_RS10240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H83_RS10270	COG0217	transcriptional regulatory protein
C2H83_RS10275	COG0494	nUDIX hydrolase
C2H83_RS10285	COG1335	isochorismatase
C2H83_RS10290	COG1801	Protein of unknown function DUF72
C2H83_RS10295	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2H83_RS10310	COG0243	molybdopterin cofactor binding
C2H83_RS10315	COG3005	denitrification pathway
C2H83_RS10325	COG3102	Protein conserved in bacteria
C2H83_RS10340	COG3755	Protein conserved in bacteria
C2H83_RS10350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H83_RS10355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H83_RS10360	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2H83_RS10365	COG0745	RESPONSE REGULATOR receiver
C2H83_RS10370	COG2201	protein-glutamate methylesterase activity
C2H83_RS10375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H83_RS10380	COG0840	transmembrane signaling receptor activity
C2H83_RS10385	COG0840	transmembrane signaling receptor activity
C2H83_RS10390	COG0835	chemotaxis
C2H83_RS10395	COG2198	Histidine kinase
C2H83_RS10395	COG0643	Histidine kinase
C2H83_RS10400	COG1360	Flagellar Motor Protein
C2H83_RS10405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H83_RS10430	COG0589	response to stress
C2H83_RS10440	COG1877	trehalose-phosphatase activity
C2H83_RS10445	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS10450	COG1129	ABC transporter
C2H83_RS10455	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS10465	COG1528	Iron-storage protein
C2H83_RS10485	COG1528	Iron-storage protein
C2H83_RS10495	COG0814	amino acid
C2H83_RS10500	COG3318	Belongs to the UPF0149 family
C2H83_RS10500	COG3012	SEC-C Motif Domain Protein
C2H83_RS10530	COG2197	response regulator
C2H83_RS10540	COG2197	response regulator
C2H83_RS10545	COG1126	abc transporter atp-binding protein
C2H83_RS10550	COG0765	amino acid transport
C2H83_RS10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS10570	COG1191	sigma factor activity
C2H83_RS10575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H83_RS10585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H83_RS10590	COG1516	flagellar protein fliS
C2H83_RS10600	COG0366	Alpha amylase catalytic
C2H83_RS10615	COG2391	methyltransferase activity
C2H83_RS10620	COG0425	Belongs to the sulfur carrier protein TusA family
C2H83_RS10625	COG2135	peptidase activity
C2H83_RS10630	COG0454	-acetyltransferase
C2H83_RS10655	COG1766	The M ring may be actively involved in energy transduction
C2H83_RS10660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H83_RS10665	COG1317	bacterial-type flagellum organization
C2H83_RS10670	COG1157	protein secretion by the type III secretion system
C2H83_RS10675	COG2882	bacterial-type flagellum organization
C2H83_RS10680	COG3144	bacterial-type flagellum assembly
C2H83_RS10685	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H83_RS10690	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H83_RS10695	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H83_RS10700	COG3190	flagellar
C2H83_RS10705	COG1338	Plays a role in the flagellum-specific transport system
C2H83_RS10710	COG1987	bacterial-type flagellum assembly
C2H83_RS10715	COG1684	flagellar biosynthetic protein fliR
C2H83_RS10720	COG2197	response regulator
C2H83_RS10740	COG3706	GGDEF domain
C2H83_RS10750	COG5475	Uncharacterized small protein (DUF2158)
C2H83_RS10755	COG2354	Protein conserved in bacteria
C2H83_RS10760	COG0697	spore germination
C2H83_RS10765	COG3727	T/G mismatch-specific endonuclease activity
C2H83_RS10770	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2H83_RS10775	COG1418	mRNA catabolic process
C2H83_RS10800	COG2205	protein histidine kinase activity
C2H83_RS10805	COG0745	RESPONSE REGULATOR receiver
C2H83_RS10810	COG2351	hydroxyisourate hydrolase activity
C2H83_RS10815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H83_RS10825	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H83_RS10830	COG3038	cytochrome b561
C2H83_RS10855	COG1470	cell adhesion involved in biofilm formation
C2H83_RS10855	COG1388	LysM domain
C2H83_RS10865	COG0477	Major facilitator Superfamily
C2H83_RS10870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H83_RS10875	COG0217	transcriptional regulatory protein
C2H83_RS10895	COG0534	Mate efflux family protein
C2H83_RS10905	COG0583	DNA-binding transcription factor activity
C2H83_RS10910	COG0583	DNA-binding transcription factor activity
C2H83_RS10920	COG1376	ErfK ybiS ycfS ynhG family protein
C2H83_RS10935	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C2H83_RS10945	COG3039	Transposase
C2H83_RS10965	COG4771	TonB-dependent receptor
C2H83_RS10975	COG4771	TonB-dependent receptor
C2H83_RS10985	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS10990	COG2020	methyltransferase activity
C2H83_RS10995	COG2003	Belongs to the UPF0758 family
C2H83_RS11035	COG1289	transmembrane transporter activity
C2H83_RS11045	COG1686	Belongs to the peptidase S11 family
C2H83_RS11050	COG2925	Exonuclease
C2H83_RS11055	COG0425	Belongs to the sulfur carrier protein TusA family
C2H83_RS11060	COG2391	methyltransferase activity
C2H83_RS11065	COG0531	amino acid
C2H83_RS11075	COG0583	DNA-binding transcription factor activity
C2H83_RS11080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H83_RS11085	COG4115	mRNA cleavage
C2H83_RS11090	COG2161	toxin-antitoxin pair type II binding
C2H83_RS11110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H83_RS11120	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H83_RS11120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2H83_RS11125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H83_RS11140	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H83_RS11140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H83_RS11145	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2H83_RS11150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H83_RS11155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H83_RS11180	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS11185	COG0110	maltose O-acetyltransferase activity
C2H83_RS11190	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS11200	COG0562	UDP-galactopyranose mutase
C2H83_RS11205	COG2244	polysaccharide biosynthetic process
C2H83_RS11210	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2H83_RS11215	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H83_RS11220	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H83_RS11225	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H83_RS11235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H83_RS11245	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS11250	COG2327	Polysaccharide pyruvyl transferase
C2H83_RS11255	COG2244	polysaccharide biosynthetic process
C2H83_RS11260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H83_RS11265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H83_RS11270	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C2H83_RS11270	COG0662	Cupin 2, conserved barrel domain protein
C2H83_RS11275	COG0297	glycogen (starch) synthase activity
C2H83_RS11280	COG1051	belongs to the nudix hydrolase family
C2H83_RS11285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H83_RS11290	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2H83_RS11295	COG0110	maltose O-acetyltransferase activity
C2H83_RS11300	COG1216	Glycosyl transferase, family 2
C2H83_RS11310	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS11315	COG1045	serine acetyltransferase
C2H83_RS11320	COG0463	Glycosyl transferase, family 2
C2H83_RS11325	COG3206	protein involved in exopolysaccharide biosynthesis
C2H83_RS11325	COG0489	protein tyrosine kinase activity
C2H83_RS11330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H83_RS11335	COG1596	polysaccharide export
C2H83_RS11340	COG1253	flavin adenine dinucleotide binding
C2H83_RS11345	COG2982	Protein involved in outer membrane biogenesis
C2H83_RS11355	COG0572	uridine kinase
C2H83_RS11360	COG5002	protein histidine kinase activity
C2H83_RS11360	COG5001	Diguanylate cyclase
C2H83_RS11360	COG3447	MASE1 domain protein
C2H83_RS11365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H83_RS11375	COG0443	Heat shock 70 kDa protein
C2H83_RS11380	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C2H83_RS11385	COG3779	Protein conserved in bacteria
C2H83_RS11390	COG0631	protein serine/threonine phosphatase activity
C2H83_RS11395	COG4245	von Willebrand factor, type A
C2H83_RS11430	COG2205	protein histidine kinase activity
C2H83_RS11435	COG0745	RESPONSE REGULATOR receiver
C2H83_RS11440	COG3422	double-strand break repair
C2H83_RS11445	COG0826	peptidase U32
C2H83_RS11490	COG1063	alcohol dehydrogenase
C2H83_RS11495	COG3775	system Galactitol-specific IIC component
C2H83_RS11500	COG3414	Phosphotransferase system galactitol-specific IIB component
C2H83_RS11505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS11520	COG1830	Aldolase
C2H83_RS11525	COG2211	Major facilitator Superfamily
C2H83_RS11530	COG1397	ADP-ribosylglycohydrolase
C2H83_RS11535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS11540	COG2188	Transcriptional regulator
C2H83_RS11545	COG3757	hydrolase, family 25
C2H83_RS11550	COG0351	phosphomethylpyrimidine kinase
C2H83_RS11565	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2H83_RS11570	COG5455	response to cobalt ion
C2H83_RS11575	COG3539	Fimbrial protein
C2H83_RS11580	COG3188	usher protein
C2H83_RS11585	COG3121	Chaperone
C2H83_RS11590	COG3539	Fimbrial protein
C2H83_RS11605	COG0489	protein tyrosine kinase activity
C2H83_RS11630	COG3831	ATPase activity
C2H83_RS11640	COG0714	Associated with various cellular activities
C2H83_RS11645	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C2H83_RS11650	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C2H83_RS11655	COG4715	Zinc finger, swim domain protein
C2H83_RS11660	COG4808	Protein conserved in bacteria
C2H83_RS11665	COG4807	Protein conserved in bacteria
C2H83_RS11670	COG3279	Response regulator of the LytR AlgR family
C2H83_RS11675	COG3275	phosphorelay sensor kinase activity
C2H83_RS11680	COG0789	Transcriptional regulator
C2H83_RS11690	COG1174	glycine betaine transport
C2H83_RS11695	COG1125	glycine betaine transport
C2H83_RS11700	COG1174	glycine betaine transport
C2H83_RS11705	COG1732	Glycine betaine
C2H83_RS11710	COG1472	Belongs to the glycosyl hydrolase 3 family
C2H83_RS11715	COG0277	FAD linked oxidase domain protein
C2H83_RS11720	COG1686	Belongs to the peptidase S11 family
C2H83_RS11730	COG0586	Pfam SNARE associated Golgi protein
C2H83_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS11760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H83_RS11770	COG1346	cytolysis
C2H83_RS11780	COG2949	membrane
C2H83_RS11790	COG0493	'glutamate synthase
C2H83_RS11795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2H83_RS11795	COG0167	dihydroorotate dehydrogenase activity
C2H83_RS11800	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS11805	COG1129	ABC transporter
C2H83_RS11810	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS11815	COG1609	Transcriptional regulator
C2H83_RS11825	COG2311	Membrane
C2H83_RS11850	COG4771	TonB-dependent receptor
C2H83_RS11860	COG0833	amino acid
C2H83_RS11870	COG0583	DNA-binding transcription factor activity
C2H83_RS11875	COG2855	membrane
C2H83_RS11885	COG1522	sequence-specific DNA binding
C2H83_RS11885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS11890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H83_RS11900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H83_RS11905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H83_RS11910	COG2313	pseudouridylate synthase activity
C2H83_RS11915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS11920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS11920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS11920	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2H83_RS11925	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H83_RS11930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS11930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS11935	COG2814	Major facilitator Superfamily
C2H83_RS11950	COG0246	Mannitol dehydrogenase
C2H83_RS11955	COG0523	cobalamin synthesis protein
C2H83_RS11960	COG0671	phosphoesterase, PA-phosphatase related
C2H83_RS11965	COG0791	NLP P60 protein
C2H83_RS11970	COG2200	EAL domain
C2H83_RS11975	COG4166	transmembrane transport
C2H83_RS11980	COG4174	ABC transporter (Permease)
C2H83_RS11985	COG4239	(ABC) transporter, permease
C2H83_RS11990	COG4172	Belongs to the ABC transporter superfamily
C2H83_RS12005	COG2814	Major facilitator Superfamily
C2H83_RS12010	COG1187	pseudouridine synthase activity
C2H83_RS12020	COG1061	Type III restriction enzyme res subunit
C2H83_RS12040	COG3083	sulfuric ester hydrolase activity
C2H83_RS12055	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS12080	COG2197	response regulator
C2H83_RS12085	COG3088	subunit of a heme lyase
C2H83_RS12085	COG4235	cytochrome complex assembly
C2H83_RS12090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H83_RS12095	COG1138	Cytochrome C-type biogenesis protein
C2H83_RS12105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H83_RS12110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H83_RS12115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H83_RS12120	COG4133	protoheme IX ABC transporter activity
C2H83_RS12125	COG3005	denitrification pathway
C2H83_RS12130	COG3043	anaerobic respiration
C2H83_RS12135	COG0348	domain, Protein
C2H83_RS12140	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS12150	COG3062	negative regulation of establishment of protein localization
C2H83_RS12155	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS12155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS12175	COG4615	Cyclic peptide transporter
C2H83_RS12180	COG3145	DNA-N1-methyladenine dioxygenase activity
C2H83_RS12185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H83_RS12185	COG2169	Transcriptional regulator
C2H83_RS12190	COG1477	protein flavinylation
C2H83_RS12195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2H83_RS12210	COG0642	Histidine kinase
C2H83_RS12210	COG2198	Histidine kinase
C2H83_RS12215	COG2197	response regulator
C2H83_RS12220	COG0784	Response regulator, receiver
C2H83_RS12220	COG2205	protein histidine kinase activity
C2H83_RS12225	COG3852	Histidine kinase
C2H83_RS12230	COG2204	response regulator
C2H83_RS12235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H83_RS12240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H83_RS12245	COG2031	fatty acid transporter
C2H83_RS12250	COG0183	Belongs to the thiolase family
C2H83_RS12255	COG4676	Protein conserved in bacteria
C2H83_RS12260	COG5445	Predicted secreted protein (DUF2300)
C2H83_RS12265	COG2373	Large extracellular alpha-helical protein
C2H83_RS12275	COG3234	Protein of unknown function (DUF1175)
C2H83_RS12280	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C2H83_RS12285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H83_RS12295	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS12305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H83_RS12310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H83_RS12315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H83_RS12320	COG3642	lipopolysaccharide core region biosynthetic process
C2H83_RS12325	COG0583	DNA-binding transcription factor activity
C2H83_RS12330	COG0584	glycerophosphoryl diester phosphodiesterase
C2H83_RS12335	COG2271	Major facilitator Superfamily
C2H83_RS12340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H83_RS12350	COG0247	lactate metabolic process
C2H83_RS12355	COG5464	transposase or invertase
C2H83_RS12370	COG2271	Major facilitator Superfamily
C2H83_RS12380	COG1414	Transcriptional regulator
C2H83_RS12445	COG0318	PFAM AMP-dependent synthetase and ligase
C2H83_RS12455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H83_RS12470	COG1169	isochorismate synthase
C2H83_RS12475	COG4575	ribosome binding
C2H83_RS12480	COG2153	protein acetylation
C2H83_RS12490	COG5160	protein modification by small protein removal
C2H83_RS12495	COG2304	oxidoreductase activity
C2H83_RS12500	COG2234	aminopeptidase activity
C2H83_RS12520	COG0457	Tetratricopeptide repeat
C2H83_RS12530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2H83_RS12535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H83_RS12545	COG0839	Belongs to the complex I subunit 6 family
C2H83_RS12560	COG1034	ATP synthesis coupled electron transport
C2H83_RS12565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C2H83_RS12570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2H83_RS12590	COG0583	DNA-binding transcription factor activity
C2H83_RS12600	COG0436	Aminotransferase
C2H83_RS12610	COG0490	domain, Protein
C2H83_RS12610	COG0471	metal ion transport
C2H83_RS12615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H83_RS12630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H83_RS12635	COG0857	belongs to the CobB CobQ family
C2H83_RS12635	COG0280	phosphate acetyltransferase
C2H83_RS12640	COG1288	antiporter activity
C2H83_RS12645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2H83_RS12650	COG0622	Phosphoesterase
C2H83_RS12655	COG0625	glutathione transferase activity
C2H83_RS12660	COG0625	glutathione transferase activity
C2H83_RS12665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H83_RS12670	COG1090	epimerase
C2H83_RS12675	COG5464	transposase or invertase
C2H83_RS12680	COG4598	ABC transporter
C2H83_RS12685	COG4160	amino acid transport
C2H83_RS12690	COG4215	(ABC) transporter
C2H83_RS12695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS12700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS12705	COG0163	prenyltransferase activity
C2H83_RS12710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H83_RS12715	COG1286	toxin biosynthetic process
C2H83_RS12720	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2H83_RS12725	COG0285	dihydrofolate synthase activity
C2H83_RS12735	COG0586	Pfam SNARE associated Golgi protein
C2H83_RS12745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H83_RS12760	COG2814	Major facilitator Superfamily
C2H83_RS12770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H83_RS12785	COG3101	peptidyl-lysine hydroxylation
C2H83_RS12790	COG0730	response to heat
C2H83_RS12805	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H83_RS12820	COG3539	Fimbrial protein
C2H83_RS12825	COG3539	Fimbrial protein
C2H83_RS12830	COG3539	Fimbrial protein
C2H83_RS12835	COG3121	Chaperone
C2H83_RS12845	COG3539	Fimbrial protein
C2H83_RS12850	COG2062	phosphohistidine phosphatase, SixA
C2H83_RS12865	COG3691	Protein conserved in bacteria
C2H83_RS12875	COG2067	long-chain fatty acid transport protein
C2H83_RS12890	COG2853	Lipoprotein
C2H83_RS12900	COG2116	formate transmembrane transporter activity
C2H83_RS12910	COG0582	viral genome integration into host DNA
C2H83_RS12915	COG2246	polysaccharide biosynthetic process
C2H83_RS12920	COG0463	Glycosyl transferase, family 2
C2H83_RS12945	COG4725	Belongs to the MT-A70-like family
C2H83_RS12965	COG5532	Uncharacterized conserved protein (DUF2303)
C2H83_RS12970	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2H83_RS12990	COG0583	DNA-binding transcription factor activity
C2H83_RS12995	COG2610	gluconate transmembrane transporter activity
C2H83_RS13005	COG0477	Major facilitator Superfamily
C2H83_RS13010	COG1566	PFAM secretion protein HlyD family protein
C2H83_RS13015	COG2197	response regulator
C2H83_RS13020	COG0784	Response regulator, receiver
C2H83_RS13020	COG2205	protein histidine kinase activity
C2H83_RS13020	COG2198	Histidine kinase
C2H83_RS13020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS13025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2H83_RS13030	COG0679	Auxin Efflux Carrier
C2H83_RS13035	COG0028	Belongs to the TPP enzyme family
C2H83_RS13065	COG1560	Kdo2-lipid A biosynthetic process
C2H83_RS13075	COG0436	Aminotransferase
C2H83_RS13080	COG3275	phosphorelay sensor kinase activity
C2H83_RS13085	COG3279	Response regulator of the LytR AlgR family
C2H83_RS13090	COG2207	Transcriptional regulator
C2H83_RS13095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS13095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H83_RS13095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS13100	COG1363	Peptidase, m42
C2H83_RS13105	COG0006	proline dipeptidase activity
C2H83_RS13110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS13115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS13140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H83_RS13145	COG3385	transposase activity
C2H83_RS13150	COG2199	diguanylate cyclase activity
C2H83_RS13150	COG2200	EAL domain
C2H83_RS13165	COG3415	Transposase
C2H83_RS13170	COG3415	Transposase
C2H83_RS13205	COG0583	DNA-binding transcription factor activity
C2H83_RS13215	COG2211	Major facilitator Superfamily
C2H83_RS13220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2H83_RS13230	COG0583	DNA-binding transcription factor activity
C2H83_RS13235	COG0385	Bile acid
C2H83_RS13240	COG3530	Putative quorum-sensing-regulated virulence factor
C2H83_RS13260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H83_RS13265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS13270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H83_RS13275	COG2190	(PTS) system
C2H83_RS13290	COG4884	unkown
C2H83_RS13290	COG3831	ATPase activity
C2H83_RS13295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H83_RS13300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2H83_RS13305	COG4208	sulfate ABC transporter
C2H83_RS13310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2H83_RS13315	COG4150	thiosulfate binding
C2H83_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS13340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS13340	COG1263	PTS System
C2H83_RS13345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H83_RS13350	COG2837	iron assimilation
C2H83_RS13365	COG0456	acetyltransferase
C2H83_RS13370	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H83_RS13380	COG2207	Transcriptional regulator
C2H83_RS13385	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2H83_RS13390	COG4816	utilization protein
C2H83_RS13400	COG4303	Ethanolamine ammonia lyase large subunit
C2H83_RS13405	COG0582	viral genome integration into host DNA
C2H83_RS13450	COG4819	ethanolamine utilization protein
C2H83_RS13455	COG3192	ethanolamine utilization protein
C2H83_RS13460	COG1454	alcohol dehydrogenase
C2H83_RS13465	COG4820	ethanolamine utilization protein (EutJ)
C2H83_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS13475	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C2H83_RS13480	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C2H83_RS13485	COG0280	phosphate acetyltransferase
C2H83_RS13490	COG4812	Cobalamin adenosyltransferase
C2H83_RS13495	COG4766	ethanolamine catabolic process
C2H83_RS13500	COG4917	ethanolamine utilization protein
C2H83_RS13505	COG4810	utilization protein
C2H83_RS13510	COG0281	malic enzyme
C2H83_RS13510	COG0280	phosphate acetyltransferase
C2H83_RS13515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H83_RS13520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H83_RS13525	COG5342	invasion associated locus B
C2H83_RS13535	COG0493	'glutamate synthase
C2H83_RS13535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS13540	COG3850	Histidine kinase
C2H83_RS13545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H83_RS13555	COG1393	Belongs to the ArsC family
C2H83_RS13570	COG0400	carboxylic ester hydrolase activity
C2H83_RS13575	COG1444	tRNA N-acetyltransferase activity
C2H83_RS13580	COG2321	neutral zinc metallopeptidase
C2H83_RS13590	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2H83_RS13600	COG2716	regulation of RNA biosynthetic process
C2H83_RS13605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H83_RS13610	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS13615	COG0651	ATP synthesis coupled electron transport
C2H83_RS13620	COG0650	Formate hydrogenlyase subunit 4
C2H83_RS13625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H83_RS13630	COG4237	Hydrogenase 4 membrane
C2H83_RS13635	COG0651	ATP synthesis coupled electron transport
C2H83_RS13640	COG3261	NADH dehydrogenase
C2H83_RS13640	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2H83_RS13645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2H83_RS13650	COG3260	NADH ubiquinone oxidoreductase 20
C2H83_RS13660	COG3604	Transcriptional regulator
C2H83_RS13665	COG2116	formate transmembrane transporter activity
C2H83_RS13675	COG0628	permease
C2H83_RS13680	COG4783	chaperone-mediated protein folding
C2H83_RS13685	COG1393	Belongs to the ArsC family
C2H83_RS13695	COG2233	PERMEase
C2H83_RS13715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H83_RS13720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2H83_RS13725	COG0248	Ppx GppA phosphatase
C2H83_RS13730	COG2200	EAL domain
C2H83_RS13750	COG3133	Outer membrane lipoprotein
C2H83_RS13765	COG0516	GMP reductase activity
C2H83_RS13765	COG0517	IMP dehydrogenase activity
C2H83_RS13775	COG1645	bacterial-type flagellum-dependent swarming motility
C2H83_RS13785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H83_RS13790	COG2976	Protein conserved in bacteria
C2H83_RS13825	COG4953	penicillin-binding protein 1C
C2H83_RS13830	COG2373	Large extracellular alpha-helical protein
C2H83_RS13835	COG2897	thiosulfate sulfurtransferase activity
C2H83_RS13850	COG2975	iron-sulfur cluster assembly
C2H83_RS13855	COG0633	Ferredoxin
C2H83_RS13875	COG0822	iron-sulfur transferase activity
C2H83_RS13895	COG0483	inositol monophosphate 1-phosphatase activity
C2H83_RS13900	COG1073	alpha beta
C2H83_RS13905	COG3711	transcriptional antiterminator
C2H83_RS13910	COG2814	Major facilitator Superfamily
C2H83_RS13915	COG0583	DNA-binding transcription factor activity
C2H83_RS13920	COG4638	Rieske (2fe-2S)
C2H83_RS13945	COG2259	Doxx family
C2H83_RS13950	COG2017	converts alpha-aldose to the beta-anomer
C2H83_RS13955	COG1063	alcohol dehydrogenase
C2H83_RS13960	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS13965	COG1129	ABC transporter
C2H83_RS13970	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS13975	COG0457	Tetratricopeptide repeat
C2H83_RS13980	COG1940	carbohydrate kinase activity
C2H83_RS13990	COG1017	nitric oxide dioxygenase activity
C2H83_RS13990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H83_RS13995	COG0347	Belongs to the P(II) protein family
C2H83_RS14000	COG2204	response regulator
C2H83_RS14005	COG3170	Tfp pilus assembly protein FimV
C2H83_RS14010	COG2205	protein histidine kinase activity
C2H83_RS14015	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H83_RS14015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H83_RS14035	COG0560	Phosphoserine phosphatase
C2H83_RS14040	COG1737	Transcriptional regulator
C2H83_RS14045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS14070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2H83_RS14095	COG0681	Belongs to the peptidase S26 family
C2H83_RS14105	COG3086	response to oxidative stress
C2H83_RS14110	COG3026	antisigma factor binding
C2H83_RS14115	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2H83_RS14120	COG1595	DNA-templated transcription, initiation
C2H83_RS14125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H83_RS14135	COG0513	Belongs to the DEAD box helicase family
C2H83_RS14140	COG0583	DNA-binding transcription factor activity
C2H83_RS14160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H83_RS14170	COG3118	belongs to the thioredoxin family
C2H83_RS14175	COG3148	PFAM DTW domain containing protein
C2H83_RS14180	COG1042	CoA-binding domain protein
C2H83_RS14180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H83_RS14180	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H83_RS14185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H83_RS14190	COG5544	Lipoprotein
C2H83_RS14195	COG0477	Major facilitator Superfamily
C2H83_RS14225	COG0542	response to heat
C2H83_RS14230	COG1496	oxidoreductase activity
C2H83_RS14235	COG0564	pseudouridine synthase activity
C2H83_RS14240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H83_RS14250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H83_RS14260	COG1605	Chorismate mutase
C2H83_RS14260	COG0077	Prephenate dehydratase
C2H83_RS14265	COG0287	Prephenate dehydrogenase
C2H83_RS14265	COG1605	Chorismate mutase
C2H83_RS14270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2H83_RS14285	COG2199	diguanylate cyclase activity
C2H83_RS14290	COG2885	chlorophyll binding
C2H83_RS14315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H83_RS14320	COG4137	Cytochrome C assembly protein
C2H83_RS14325	COG4536	flavin adenine dinucleotide binding
C2H83_RS14345	COG0497	DNA recombination
C2H83_RS14350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H83_RS14360	COG2867	negative regulation of translational initiation
C2H83_RS14375	COG0582	viral genome integration into host DNA
C2H83_RS14385	COG3311	Transcriptional regulator
C2H83_RS14390	COG4983	Phage plasmid primase, P4 family domain protein
C2H83_RS14400	COG1204	response to ionizing radiation
C2H83_RS14410	COG1479	Protein of unknown function DUF262
C2H83_RS14425	COG3596	GTP binding
C2H83_RS14435	COG2378	regulation of single-species biofilm formation
C2H83_RS14480	COG2003	Belongs to the UPF0758 family
C2H83_RS14500	COG3468	outer membrane autotransporter barrel domain protein
C2H83_RS14530	COG0366	Alpha amylase catalytic
C2H83_RS14550	COG0579	oxidoreductase
C2H83_RS14555	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS14560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H83_RS14565	COG1113	amino acid transport
C2H83_RS14570	COG1802	Transcriptional regulator
C2H83_RS14575	COG1652	LysM domain
C2H83_RS14580	COG0401	homolog of Blt101
C2H83_RS14585	COG0640	Transcriptional regulator
C2H83_RS14590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H83_RS14595	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2H83_RS14610	COG4575	ribosome binding
C2H83_RS14615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2H83_RS14625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H83_RS14630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H83_RS14640	COG4175	Glycine betaine
C2H83_RS14645	COG4176	ABC-type proline glycine betaine transport system permease component
C2H83_RS14650	COG2113	Glycine betaine
C2H83_RS14660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2H83_RS14670	COG1846	Transcriptional regulator
C2H83_RS14675	COG1566	PFAM secretion protein HlyD family protein
C2H83_RS14680	COG2814	Major facilitator Superfamily
C2H83_RS14695	COG1238	metal cluster binding
C2H83_RS14700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H83_RS14730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H83_RS14750	COG1546	Belongs to the CinA family
C2H83_RS14755	COG2951	lytic endotransglycosylase activity
C2H83_RS14760	COG3730	PTS system glucitol sorbitol-specific
C2H83_RS14765	COG3732	PTS system glucitol sorbitol-specific
C2H83_RS14770	COG3731	PTS system glucitol sorbitol-specific IIA component
C2H83_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS14780	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS14785	COG1349	DNA-binding transcription factor activity
C2H83_RS14790	COG0517	IMP dehydrogenase activity
C2H83_RS14790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H83_RS14810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2H83_RS14815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS14820	COG1609	Transcriptional regulator
C2H83_RS14825	COG1263	PTS System
C2H83_RS14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS14830	COG2723	6-phospho-beta-galactosidase activity
C2H83_RS14835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H83_RS14845	COG3260	NADH ubiquinone oxidoreductase 20
C2H83_RS14850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2H83_RS14855	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2H83_RS14855	COG3261	NADH dehydrogenase
C2H83_RS14860	COG0650	Formate hydrogenlyase subunit 4
C2H83_RS14865	COG0651	ATP synthesis coupled electron transport
C2H83_RS14870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS14880	COG0375	protein maturation
C2H83_RS14885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2H83_RS14890	COG0298	carbon dioxide binding
C2H83_RS14895	COG0409	Hydrogenase expression formation protein
C2H83_RS14900	COG0309	Hydrogenase expression formation protein (HypE)
C2H83_RS14905	COG3604	Transcriptional regulator
C2H83_RS14920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H83_RS14925	COG1349	DNA-binding transcription factor activity
C2H83_RS14930	COG2084	Dehydrogenase
C2H83_RS14935	COG3395	kinase activity
C2H83_RS14940	COG0235	Class ii aldolase
C2H83_RS14945	COG3622	Belongs to the hyi family
C2H83_RS14950	COG2610	gluconate transmembrane transporter activity
C2H83_RS14955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H83_RS14960	COG4942	peptidase
C2H83_RS14960	COG1388	LysM domain
C2H83_RS15015	COG2234	aminopeptidase activity
C2H83_RS15020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H83_RS15025	COG1518	maintenance of DNA repeat elements
C2H83_RS15040	COG1857	crispr-associated protein
C2H83_RS15055	COG1203	CRISPR-associated helicase, Cas3
C2H83_RS15075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H83_RS15080	COG0720	synthase
C2H83_RS15085	COG0644	oxidoreductase
C2H83_RS15090	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C2H83_RS15095	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H83_RS15100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H83_RS15105	COG2086	electron transfer activity
C2H83_RS15110	COG0477	Major facilitator Superfamily
C2H83_RS15115	COG0277	FAD linked oxidase domain protein
C2H83_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS15125	COG2223	nitrite transmembrane transporter activity
C2H83_RS15130	COG1070	Carbohydrate kinase
C2H83_RS15135	COG0602	queuosine metabolic process
C2H83_RS15145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H83_RS15160	COG3956	TIGRFAM MazG family protein
C2H83_RS15165	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H83_RS15170	COG2336	PFAM SpoVT AbrB
C2H83_RS15175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H83_RS15180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H83_RS15185	COG3850	Histidine kinase
C2H83_RS15185	COG3437	response regulator, receiver
C2H83_RS15185	COG4999	Histidine kinase
C2H83_RS15185	COG2205	protein histidine kinase activity
C2H83_RS15190	COG4948	Mandelate Racemase Muconate Lactonizing
C2H83_RS15195	COG4948	Mandelate Racemase Muconate Lactonizing
C2H83_RS15200	COG2271	Major facilitator Superfamily
C2H83_RS15205	COG0716	FMN binding
C2H83_RS15210	COG0564	pseudouridine synthase activity
C2H83_RS15215	COG3098	single-species biofilm formation
C2H83_RS15230	COG1611	Belongs to the LOG family
C2H83_RS15235	COG0814	amino acid
C2H83_RS15240	COG1760	l-serine dehydratase
C2H83_RS15250	COG1454	alcohol dehydrogenase
C2H83_RS15255	COG0235	Class ii aldolase
C2H83_RS15260	COG0738	Major facilitator superfamily
C2H83_RS15270	COG1070	Carbohydrate kinase
C2H83_RS15280	COG1349	DNA-binding transcription factor activity
C2H83_RS15290	COG2363	Small membrane protein
C2H83_RS15295	COG0583	DNA-binding transcription factor activity
C2H83_RS15305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H83_RS15310	COG2166	iron-sulfur cluster assembly
C2H83_RS15315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H83_RS15320	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2H83_RS15345	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H83_RS15355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2H83_RS15355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2H83_RS15360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H83_RS15365	COG1074	ATP-dependent DNA helicase activity
C2H83_RS15370	COG1025	Belongs to the peptidase M16 family
C2H83_RS15375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2H83_RS15380	COG4967	type IV pilus modification protein PilV
C2H83_RS15390	COG4795	General secretion pathway protein
C2H83_RS15395	COG2165	general secretion pathway protein
C2H83_RS15410	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C2H83_RS15425	COG0861	Integral membrane protein TerC family
C2H83_RS15435	COG0667	Aldo Keto reductase
C2H83_RS15450	COG1609	Transcriptional regulator
C2H83_RS15460	COG0583	DNA-binding transcription factor activity
C2H83_RS15465	COG1794	racemase activity, acting on amino acids and derivatives
C2H83_RS15470	COG2814	Major facilitator Superfamily
C2H83_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS15485	COG0183	Belongs to the thiolase family
C2H83_RS15490	COG0814	amino acid
C2H83_RS15495	COG2771	luxR family
C2H83_RS15500	COG3710	Transcriptional regulator
C2H83_RS15525	COG0457	Tetratricopeptide repeat
C2H83_RS15530	COG0457	Tetratricopeptide repeat
C2H83_RS15530	COG3710	Transcriptional regulator
C2H83_RS15545	COG2197	response regulator
C2H83_RS15550	COG2197	response regulator
C2H83_RS15580	COG3387	PFAM Glycoside hydrolase 15-related
C2H83_RS15590	COG4942	peptidase
C2H83_RS15600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H83_RS15605	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H83_RS15610	COG2080	2 iron, 2 sulfur cluster binding
C2H83_RS15615	COG3829	transcription factor binding
C2H83_RS15620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H83_RS15625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H83_RS15630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H83_RS15640	COG0549	Belongs to the carbamate kinase family
C2H83_RS15645	COG3608	succinylglutamate desuccinylase aspartoacylase
C2H83_RS15645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H83_RS15650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H83_RS15655	COG2068	MobA-Related Protein
C2H83_RS15660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS15660	COG0493	'glutamate synthase
C2H83_RS15665	COG0402	S-adenosylhomocysteine deaminase activity
C2H83_RS15670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H83_RS15675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H83_RS15675	COG2080	2 iron, 2 sulfur cluster binding
C2H83_RS15680	COG2233	PERMEase
C2H83_RS15685	COG0402	S-adenosylhomocysteine deaminase activity
C2H83_RS15690	COG2252	PERMEase
C2H83_RS15695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS15700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS15700	COG0493	'glutamate synthase
C2H83_RS15710	COG2233	PERMEase
C2H83_RS15725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H83_RS15735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H83_RS15740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H83_RS15745	COG4974	Belongs to the 'phage' integrase family
C2H83_RS15750	COG0716	FMN binding
C2H83_RS15760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2H83_RS15770	COG1272	protein, Hemolysin III
C2H83_RS15780	COG2723	6-phospho-beta-galactosidase activity
C2H83_RS15785	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS15805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H83_RS15810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H83_RS15815	COG0006	proline dipeptidase activity
C2H83_RS15840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H83_RS15850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H83_RS15870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2H83_RS15870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2H83_RS15875	COG1703	isobutyryl-CoA mutase activity
C2H83_RS15880	COG1024	Enoyl-CoA hydratase
C2H83_RS15885	COG0427	acetyl-CoA hydrolase
C2H83_RS15890	COG0583	DNA-binding transcription factor activity
C2H83_RS15895	COG2968	Membrane
C2H83_RS15900	COG1279	arginine transmembrane transporter activity
C2H83_RS15905	COG0668	transmembrane transport
C2H83_RS15915	COG0191	fructose-bisphosphate aldolase activity
C2H83_RS15935	COG1072	(Pantothenic acid kinase))
C2H83_RS15940	COG3722	fumarate hydratase activity
C2H83_RS15945	COG1494	fructose-1,6-bisphosphatase
C2H83_RS15950	COG1063	alcohol dehydrogenase
C2H83_RS15955	COG2213	PTS system mannitol-specific
C2H83_RS15960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS15965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H83_RS15970	COG0501	Belongs to the peptidase M48B family
C2H83_RS15980	COG1166	arginine decarboxylase activity
C2H83_RS16005	COG2814	Major facilitator Superfamily
C2H83_RS16015	COG2356	endonuclease I
C2H83_RS16020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H83_RS16025	COG0189	ligase activity
C2H83_RS16040	COG2805	Type II/IV secretion system protein
C2H83_RS16045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H83_RS16050	COG0762	integral membrane protein
C2H83_RS16060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2H83_RS16065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H83_RS16075	COG0252	asparaginase activity
C2H83_RS16085	COG3171	Protein conserved in bacteria
C2H83_RS16100	COG1194	a g-specific adenine glycosylase
C2H83_RS16115	COG2211	Major facilitator Superfamily
C2H83_RS16120	COG1982	Orn Lys Arg decarboxylase major
C2H83_RS16130	COG1811	Na channel or pump
C2H83_RS16140	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2H83_RS16150	COG3031	protein transport across the cell outer membrane
C2H83_RS16160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H83_RS16165	COG3064	Membrane
C2H83_RS16175	COG1620	l-lactate permease
C2H83_RS16180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2H83_RS16185	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2H83_RS16190	COG0247	lactate metabolic process
C2H83_RS16195	COG0277	FAD linked oxidase domain protein
C2H83_RS16200	COG0277	FAD linked oxidase domain protein
C2H83_RS16205	COG2186	Transcriptional regulator
C2H83_RS16210	COG0456	acetyltransferase
C2H83_RS16220	COG2244	polysaccharide biosynthetic process
C2H83_RS16225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H83_RS16230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H83_RS16235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H83_RS16240	COG0306	phosphate transporter
C2H83_RS16245	COG0754	glutathionylspermidine amidase activity
C2H83_RS16250	COG0625	glutathione transferase activity
C2H83_RS16255	COG0298	carbon dioxide binding
C2H83_RS16265	COG1773	rubredoxin
C2H83_RS16270	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H83_RS16275	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2H83_RS16280	COG5557	Pfam Polysulphide reductase, NrfD
C2H83_RS16285	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS16290	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2H83_RS16315	COG0667	Aldo Keto reductase
C2H83_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS16330	COG0848	biopolymer transport protein
C2H83_RS16335	COG0811	peptide transport
C2H83_RS16345	COG0626	cystathionine gamma-synthase activity
C2H83_RS16350	COG0586	Pfam SNARE associated Golgi protein
C2H83_RS16355	COG2207	Transcriptional regulator
C2H83_RS16360	COG1979	alcohol dehydrogenase
C2H83_RS16365	COG0656	L-ascorbic acid biosynthetic process
C2H83_RS16375	COG4238	major outer membrane lipoprotein
C2H83_RS16380	COG1032	radical SAM domain protein
C2H83_RS16385	COG2132	Multicopper oxidase
C2H83_RS16390	COG0204	Acyl-transferase
C2H83_RS16395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H83_RS16400	COG4166	transmembrane transport
C2H83_RS16410	COG2944	sequence-specific DNA binding
C2H83_RS16420	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2H83_RS16425	COG3111	PFAM Bacterial OB fold (BOF) protein
C2H83_RS16430	COG0745	RESPONSE REGULATOR receiver
C2H83_RS16435	COG0642	Histidine kinase
C2H83_RS16450	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H83_RS16455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H83_RS16460	COG0187	DNA topoisomerase II activity
C2H83_RS16465	COG3150	esterase
C2H83_RS16470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2H83_RS16475	COG3151	Protein conserved in bacteria
C2H83_RS16480	COG0494	nUDIX hydrolase
C2H83_RS16485	COG1538	Outer membrane efflux protein
C2H83_RS16500	COG0754	glutathionylspermidine amidase activity
C2H83_RS16505	COG3384	dioxygenase
C2H83_RS16525	COG2960	long-chain fatty acid transporting porin activity
C2H83_RS16530	COG3539	Fimbrial protein
C2H83_RS16550	COG3188	usher protein
C2H83_RS16555	COG3121	Chaperone
C2H83_RS16560	COG3539	Fimbrial protein
C2H83_RS16570	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H83_RS16575	COG2268	Band 7 protein
C2H83_RS16605	COG3025	triphosphatase activity
C2H83_RS16615	COG4991	sh3 domain protein
C2H83_RS16630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H83_RS16640	COG0583	DNA-binding transcription factor activity
C2H83_RS16650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2H83_RS16655	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2H83_RS16660	COG0471	metal ion transport
C2H83_RS16675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2H83_RS16680	COG0358	DNA primase activity
C2H83_RS16690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H83_RS16705	COG2375	cellular response to nickel ion
C2H83_RS16710	COG1695	Transcriptional regulator
C2H83_RS16715	COG0840	transmembrane signaling receptor activity
C2H83_RS16730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H83_RS16740	COG1609	Transcriptional regulator
C2H83_RS16745	COG3250	beta-galactosidase activity
C2H83_RS16750	COG2731	YhcH YjgK YiaL family protein
C2H83_RS16755	COG0531	amino acid
C2H83_RS16765	COG3408	Glycogen debranching enzyme
C2H83_RS16765	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2H83_RS16770	COG1902	pentaerythritol trinitrate reductase activity
C2H83_RS16770	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2H83_RS16775	COG5499	transcription regulator containing HTH domain
C2H83_RS16780	COG4680	protein conserved in bacteria
C2H83_RS16795	COG1451	nucleotide metabolic process
C2H83_RS16800	COG2949	membrane
C2H83_RS16805	COG0673	inositol 2-dehydrogenase activity
C2H83_RS16810	COG0861	Integral membrane protein TerC family
C2H83_RS16815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2H83_RS16825	COG2721	sulfolactate sulfo-lyase activity
C2H83_RS16835	COG2271	Major facilitator Superfamily
C2H83_RS16840	COG2186	Transcriptional regulator
C2H83_RS16845	COG0586	Pfam SNARE associated Golgi protein
C2H83_RS16855	COG1422	Protein of unknown function (DUF1090)
C2H83_RS16860	COG4575	ribosome binding
C2H83_RS16865	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C2H83_RS16875	COG2259	Doxx family
C2H83_RS16880	COG0435	Glutathione S-transferase
C2H83_RS16885	COG3152	Membrane
C2H83_RS16890	COG3152	Membrane
C2H83_RS16900	COG0583	DNA-binding transcription factor activity
C2H83_RS16905	COG1741	Belongs to the pirin family
C2H83_RS16920	COG0814	amino acid
C2H83_RS16930	COG1760	l-serine dehydratase
C2H83_RS16935	COG0251	oxidation-reduction process
C2H83_RS16940	COG1882	Formate acetyltransferase
C2H83_RS16945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H83_RS16955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H83_RS16965	COG0583	DNA-binding transcription factor activity
C2H83_RS16990	COG1929	Belongs to the glycerate kinase type-1 family
C2H83_RS16995	COG2084	Dehydrogenase
C2H83_RS17005	COG2271	Major facilitator Superfamily
C2H83_RS17010	COG2721	sulfolactate sulfo-lyase activity
C2H83_RS17015	COG2002	toxin-antitoxin pair type II binding
C2H83_RS17025	COG1349	DNA-binding transcription factor activity
C2H83_RS17040	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS17055	COG2222	sugar isomerase
C2H83_RS17065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS17070	COG3715	PTS system
C2H83_RS17075	COG3716	PTS system mannose fructose sorbose family IID component
C2H83_RS17080	COG0363	glucosamine-6-phosphate deaminase activity
C2H83_RS17085	COG3539	Fimbrial protein
C2H83_RS17090	COG3121	Chaperone
C2H83_RS17095	COG3188	usher protein
C2H83_RS17100	COG3539	Fimbrial protein
C2H83_RS17105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H83_RS17110	COG3107	peptidoglycan biosynthetic process
C2H83_RS17125	COG2823	Periplasmic or secreted lipoprotein
C2H83_RS17130	COG0701	Predicted permease
C2H83_RS17135	COG0702	epimerase
C2H83_RS17140	COG0693	protein deglycase activity
C2H83_RS17155	COG3153	acetyltransferase
C2H83_RS17160	COG3154	lipid carrier protein
C2H83_RS17165	COG0826	peptidase U32
C2H83_RS17170	COG0826	peptidase U32
C2H83_RS17175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H83_RS17180	COG0814	amino acid
C2H83_RS17185	COG0513	Belongs to the DEAD box helicase family
C2H83_RS17225	COG0195	Participates in both transcription termination and antitermination
C2H83_RS17245	COG2194	sulfuric ester hydrolase activity
C2H83_RS17255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H83_RS17265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H83_RS17270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H83_RS17280	COG1534	Rna-binding protein
C2H83_RS17285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H83_RS17290	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H83_RS17300	COG0697	spore germination
C2H83_RS17315	COG0142	geranyltranstransferase activity
C2H83_RS17320	COG3423	Transcriptional regulator
C2H83_RS17330	COG5007	Belongs to the BolA IbaG family
C2H83_RS17335	COG3113	response to antibiotic
C2H83_RS17340	COG2854	intermembrane phospholipid transfer
C2H83_RS17345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2H83_RS17350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2H83_RS17355	COG1127	ABC transporter
C2H83_RS17360	COG0530	calcium, potassium:sodium antiporter activity
C2H83_RS17365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H83_RS17365	COG0517	IMP dehydrogenase activity
C2H83_RS17370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2H83_RS17375	COG3117	lipopolysaccharide transmembrane transporter activity
C2H83_RS17380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2H83_RS17385	COG1137	ATPase activity
C2H83_RS17390	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H83_RS17395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H83_RS17410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS17415	COG0515	serine threonine protein kinase
C2H83_RS17425	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2H83_RS17430	COG2198	Histidine kinase
C2H83_RS17430	COG0784	Response regulator, receiver
C2H83_RS17430	COG5002	protein histidine kinase activity
C2H83_RS17435	COG1242	4 iron, 4 sulfur cluster binding
C2H83_RS17450	COG0067	glutamate synthase
C2H83_RS17450	COG0070	glutamate synthase
C2H83_RS17450	COG0069	glutamate synthase activity
C2H83_RS17455	COG0493	'glutamate synthase
C2H83_RS17465	COG3539	Fimbrial protein
C2H83_RS17470	COG3121	Chaperone
C2H83_RS17475	COG3188	usher protein
C2H83_RS17495	COG3539	Fimbrial protein
C2H83_RS17500	COG4804	nuclease activity
C2H83_RS17505	COG2731	YhcH YjgK YiaL family protein
C2H83_RS17540	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H83_RS17545	COG2969	positive regulation of protein catabolic process
C2H83_RS17550	COG0625	glutathione transferase activity
C2H83_RS17570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2H83_RS17575	COG3105	Protein conserved in bacteria
C2H83_RS17580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H83_RS17585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H83_RS17605	COG2732	(Barnase) inhibitor
C2H83_RS17610	COG1289	transmembrane transporter activity
C2H83_RS17625	COG0583	DNA-binding transcription factor activity
C2H83_RS17630	COG0312	modulator of DNA gyrase
C2H83_RS17635	COG3164	Protein of unknown function
C2H83_RS17640	COG1530	ribonuclease E activity
C2H83_RS17645	COG0424	maF-like protein
C2H83_RS17650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H83_RS17655	COG1792	Involved in formation and maintenance of cell shape
C2H83_RS17660	COG1077	Cell shape determining protein MreB Mrl
C2H83_RS17675	COG2199	diguanylate cyclase activity
C2H83_RS17675	COG2200	EAL domain
C2H83_RS17680	COG0604	alcohol dehydrogenase
C2H83_RS17690	COG0511	ligase activity, forming carbon-carbon bonds
C2H83_RS17695	COG0439	Biotin carboxylase
C2H83_RS17700	COG3924	membrane
C2H83_RS17705	COG4145	pantothenate transmembrane transporter activity
C2H83_RS17715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H83_RS17725	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C2H83_RS17735	COG1309	transcriptional regulator
C2H83_RS17745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS17750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H83_RS17770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H83_RS17775	COG4597	amino acid ABC transporter
C2H83_RS17780	COG0765	amino acid transport
C2H83_RS17785	COG1126	abc transporter atp-binding protein
C2H83_RS17825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H83_RS17845	COG0551	DNA topoisomerase type I activity
C2H83_RS17855	COG0758	DNA mediated transformation
C2H83_RS17875	COG0569	domain protein
C2H83_RS17885	COG3036	rescue of stalled ribosome
C2H83_RS17890	COG0789	Transcriptional regulator
C2H83_RS17930	COG0201	protein transport
C2H83_RS18020	COG0089	rRNA binding
C2H83_RS18045	COG3267	Type II secretory pathway component ExeA
C2H83_RS18045	COG3409	Peptidoglycan-binding domain 1 protein
C2H83_RS18050	COG3031	protein transport across the cell outer membrane
C2H83_RS18055	COG1450	Type ii and iii secretion system protein
C2H83_RS18060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H83_RS18065	COG1459	type II secretion system
C2H83_RS18070	COG2165	general secretion pathway protein
C2H83_RS18075	COG2165	general secretion pathway protein
C2H83_RS18080	COG2165	general secretion pathway protein
C2H83_RS18085	COG4795	General secretion pathway protein
C2H83_RS18090	COG3156	type II secretion system protein K
C2H83_RS18095	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2H83_RS18100	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2H83_RS18105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H83_RS18110	COG2193	ferroxidase activity
C2H83_RS18115	COG2906	2 iron, 2 sulfur cluster binding
C2H83_RS18120	COG3979	chitinase
C2H83_RS18165	COG2964	Protein conserved in bacteria
C2H83_RS18170	COG0545	Peptidyl-prolyl cis-trans isomerase
C2H83_RS18180	COG1047	Peptidyl-prolyl cis-trans
C2H83_RS18185	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2H83_RS18205	COG0488	(ABC) transporter
C2H83_RS18210	COG0429	hydrolase of the alpha beta-hydrolase fold
C2H83_RS18220	COG3954	Phosphoribulokinase
C2H83_RS18225	COG1765	OsmC-like protein
C2H83_RS18235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H83_RS18240	COG1289	transmembrane transporter activity
C2H83_RS18245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H83_RS18250	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H83_RS18255	COG2184	nucleotidyltransferase activity
C2H83_RS18265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H83_RS18275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H83_RS18280	COG2146	nitrite reductase [NAD(P)H] activity
C2H83_RS18285	COG2116	formate transmembrane transporter activity
C2H83_RS18300	COG0531	amino acid
C2H83_RS18305	COG2222	sugar isomerase
C2H83_RS18315	COG1082	Xylose isomerase domain protein TIM barrel
C2H83_RS18320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS18325	COG2188	Transcriptional regulator
C2H83_RS18330	COG0626	cystathionine gamma-synthase activity
C2H83_RS18345	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C2H83_RS18350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H83_RS18355	COG3457	Alanine racemase
C2H83_RS18365	COG2188	Transcriptional regulator
C2H83_RS18375	COG0180	Tryptophanyl-tRNA synthetase
C2H83_RS18380	COG0546	phosphoglycolate phosphatase activity
C2H83_RS18385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H83_RS18390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H83_RS18395	COG3266	domain, Protein
C2H83_RS18410	COG4796	Type ii and iii secretion system protein
C2H83_RS18425	COG3166	PFAM Fimbrial assembly family protein
C2H83_RS18430	COG4972	Pilus assembly protein
C2H83_RS18435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2H83_RS18440	COG0494	nUDIX hydrolase
C2H83_RS18450	COG1011	Hydrolase
C2H83_RS18455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H83_RS18465	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2H83_RS18495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H83_RS18500	COG2183	response to ionizing radiation
C2H83_RS18510	COG1918	ferrous iron import across plasma membrane
C2H83_RS18515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2H83_RS18530	COG5464	transposase or invertase
C2H83_RS18540	COG1040	competence protein
C2H83_RS18550	COG2610	gluconate transmembrane transporter activity
C2H83_RS18555	COG1640	4-alpha-glucanotransferase
C2H83_RS18560	COG0058	SHG alpha-glucan phosphorylase activity
C2H83_RS18575	COG1690	Belongs to the RtcB family
C2H83_RS18580	COG4650	regulator
C2H83_RS18585	COG1349	DNA-binding transcription factor activity
C2H83_RS18600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H83_RS18605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H83_RS18610	COG0058	SHG alpha-glucan phosphorylase activity
C2H83_RS18635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H83_RS18640	COG2095	MarC family integral membrane protein
C2H83_RS18645	COG2610	gluconate transmembrane transporter activity
C2H83_RS18650	COG3265	gluconokinase activity
C2H83_RS18655	COG1609	Transcriptional regulator
C2H83_RS18660	COG1741	Belongs to the pirin family
C2H83_RS18665	COG0673	inositol 2-dehydrogenase activity
C2H83_RS18675	COG1247	-acetyltransferase
C2H83_RS18680	COG3157	Type VI secretion system effector, Hcp
C2H83_RS18705	COG0405	Gamma-glutamyltransferase
C2H83_RS18715	COG0584	glycerophosphoryl diester phosphodiesterase
C2H83_RS18720	COG3842	ATPase activity
C2H83_RS18725	COG0395	ABC-type sugar transport system, permease component
C2H83_RS18730	COG1175	transmembrane transport
C2H83_RS18735	COG1653	transport
C2H83_RS18740	COG0410	ABC transporter
C2H83_RS18745	COG0411	ABC transporter
C2H83_RS18750	COG4177	L-phenylalanine transmembrane transporter activity
C2H83_RS18755	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS18760	COG0683	leucine binding
C2H83_RS18765	COG0456	acetyltransferase
C2H83_RS18770	COG0683	leucine binding
C2H83_RS18775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H83_RS18780	COG2177	Part of the ABC transporter FtsEX involved in
C2H83_RS18785	COG2884	Cell division ATP-binding protein ftsE
C2H83_RS18790	COG0552	protein localization to endoplasmic reticulum
C2H83_RS18795	COG0742	ribosomal rna small subunit methyltransferase
C2H83_RS18800	COG3776	membrane
C2H83_RS18810	COG3714	YhhN family
C2H83_RS18815	COG2217	Heavy metal translocating P-type atpase
C2H83_RS18825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2H83_RS18835	COG0477	Major facilitator Superfamily
C2H83_RS18840	COG0628	permease
C2H83_RS18845	COG2091	lysine biosynthetic process via aminoadipic acid
C2H83_RS18850	COG0747	negative chemotaxis
C2H83_RS18855	COG0601	transmembrane transport
C2H83_RS18860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H83_RS18865	COG0444	Belongs to the ABC transporter superfamily
C2H83_RS18870	COG1124	(ABC) transporter
C2H83_RS18880	COG3209	COG3209 Rhs family protein
C2H83_RS18890	COG1413	lyase activity
C2H83_RS18895	COG5433	transposase activity
C2H83_RS18900	COG0842	Transport permease protein
C2H83_RS18905	COG0842	Transport permease protein
C2H83_RS18905	COG1129	ABC transporter
C2H83_RS18910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS18935	COG2081	HI0933 family
C2H83_RS18940	COG0306	phosphate transporter
C2H83_RS18950	COG0589	response to stress
C2H83_RS18960	COG3104	oligopeptide transport
C2H83_RS18970	COG0339	signal peptide processing
C2H83_RS18975	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2H83_RS18980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H83_RS18995	COG0640	Transcriptional regulator
C2H83_RS19000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H83_RS19005	COG1393	Belongs to the ArsC family
C2H83_RS19025	COG3065	identical protein binding
C2H83_RS19035	COG2197	response regulator
C2H83_RS19040	COG1285	pathogenesis
C2H83_RS19055	COG3247	response to pH
C2H83_RS19060	COG2771	luxR family
C2H83_RS19070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H83_RS19075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H83_RS19085	COG2207	Transcriptional regulator
C2H83_RS19090	COG2207	Transcriptional regulator
C2H83_RS19095	COG0076	glutamate decarboxylase activity
C2H83_RS19100	COG1858	cytochrome C peroxidase
C2H83_RS19110	COG2197	response regulator
C2H83_RS19115	COG0583	DNA-binding transcription factor activity
C2H83_RS19120	COG1295	ribonuclease BN
C2H83_RS19125	COG0477	Major facilitator Superfamily
C2H83_RS19130	COG2982	Protein involved in outer membrane biogenesis
C2H83_RS19135	COG2200	EAL domain
C2H83_RS19145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS19150	COG0612	Peptidase, M16
C2H83_RS19165	COG2199	diguanylate cyclase activity
C2H83_RS19165	COG2200	EAL domain
C2H83_RS19170	COG3118	belongs to the thioredoxin family
C2H83_RS19170	COG0457	Tetratricopeptide repeat
C2H83_RS19175	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H83_RS19180	COG1215	transferase activity, transferring glycosyl groups
C2H83_RS19185	COG1215	transferase activity, transferring glycosyl groups
C2H83_RS19210	COG2194	sulfuric ester hydrolase activity
C2H83_RS19230	COG0814	amino acid
C2H83_RS19235	COG4608	Belongs to the ABC transporter superfamily
C2H83_RS19240	COG0444	Belongs to the ABC transporter superfamily
C2H83_RS19245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H83_RS19250	COG0601	transmembrane transport
C2H83_RS19255	COG0747	negative chemotaxis
C2H83_RS19275	COG2194	sulfuric ester hydrolase activity
C2H83_RS19280	COG2223	nitrite transmembrane transporter activity
C2H83_RS19290	COG5571	outer membrane autotransporter
C2H83_RS19295	COG2818	Glycosylase
C2H83_RS19300	COG0456	acetyltransferase
C2H83_RS19305	COG0243	molybdopterin cofactor binding
C2H83_RS19310	COG2885	chlorophyll binding
C2H83_RS19325	COG2944	sequence-specific DNA binding
C2H83_RS19330	COG1278	Cold shock
C2H83_RS19350	COG0752	glycyl-tRNA synthetase alpha subunit
C2H83_RS19360	COG3274	enterobacterial common antigen metabolic process
C2H83_RS19365	COG4682	membrane
C2H83_RS19370	COG4682	membrane
C2H83_RS19375	COG1070	Carbohydrate kinase
C2H83_RS19385	COG4213	ABC transporter substrate-binding protein
C2H83_RS19390	COG1129	ABC transporter
C2H83_RS19395	COG4214	carbohydrate transport
C2H83_RS19400	COG1609	Transcriptional regulator
C2H83_RS19400	COG2207	Transcriptional regulator
C2H83_RS19405	COG2992	FlgJ-related protein
C2H83_RS19410	COG0366	Alpha amylase catalytic
C2H83_RS19415	COG3977	Valine--pyruvate aminotransferase
C2H83_RS19420	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2H83_RS19425	COG1414	Transcriptional regulator
C2H83_RS19435	COG2731	YhcH YjgK YiaL family protein
C2H83_RS19440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C2H83_RS19445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2H83_RS19450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2H83_RS19455	COG1070	Carbohydrate kinase
C2H83_RS19460	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H83_RS19465	COG3623	hexulose-6-phosphate isomerase
C2H83_RS19470	COG0235	Class ii aldolase
C2H83_RS19480	COG3713	MltA-interacting MipA family protein
C2H83_RS19485	COG0583	DNA-binding transcription factor activity
C2H83_RS19490	COG1566	PFAM secretion protein HlyD family protein
C2H83_RS19505	COG1012	belongs to the aldehyde dehydrogenase family
C2H83_RS19510	COG1454	alcohol dehydrogenase
C2H83_RS19515	COG3276	selenocysteine insertion sequence binding
C2H83_RS19525	COG0625	glutathione transferase activity
C2H83_RS19530	COG3209	COG3209 Rhs family protein
C2H83_RS19535	COG1413	lyase activity
C2H83_RS19545	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2H83_RS19565	COG1566	PFAM secretion protein HlyD family protein
C2H83_RS19575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS19575	COG2213	PTS system mannitol-specific
C2H83_RS19585	COG3722	fumarate hydratase activity
C2H83_RS19605	COG1620	l-lactate permease
C2H83_RS19610	COG2186	Transcriptional regulator
C2H83_RS19620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2H83_RS19625	COG1045	serine acetyltransferase
C2H83_RS19640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2H83_RS19645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H83_RS19655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H83_RS19660	COG4942	peptidase
C2H83_RS19665	COG2861	carbohydrate metabolic process
C2H83_RS19670	COG1216	Glycosyl transferase, family 2
C2H83_RS19680	COG0156	8-amino-7-oxononanoate synthase activity
C2H83_RS19695	COG0859	PFAM glycosyl transferase family 9
C2H83_RS19700	COG0859	PFAM glycosyl transferase family 9
C2H83_RS19705	COG3307	-O-antigen
C2H83_RS19710	COG0859	PFAM glycosyl transferase family 9
C2H83_RS19720	COG3642	lipopolysaccharide core region biosynthetic process
C2H83_RS19725	COG1442	glycosyl transferase family 8
C2H83_RS19730	COG1442	glycosyl transferase family 8
C2H83_RS19735	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS19740	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS19740	COG4641	Protein conserved in bacteria
C2H83_RS19745	COG0515	serine threonine protein kinase
C2H83_RS19750	COG0438	transferase activity, transferring glycosyl groups
C2H83_RS19755	COG0859	PFAM glycosyl transferase family 9
C2H83_RS19760	COG1519	Transferase
C2H83_RS19790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H83_RS19820	COG1561	YicC-like family, N-terminal region
C2H83_RS19825	COG3645	SOS response
C2H83_RS19830	COG2860	membrane
C2H83_RS19840	COG0194	GDP metabolic process
C2H83_RS19850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H83_RS19855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H83_RS19860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H83_RS19865	COG0786	glutamate:sodium symporter activity
C2H83_RS19870	COG2233	PERMEase
C2H83_RS19875	COG2982	Protein involved in outer membrane biogenesis
C2H83_RS19880	COG1501	Belongs to the glycosyl hydrolase 31 family
C2H83_RS19885	COG2211	Major facilitator Superfamily
C2H83_RS19900	COG2814	Major facilitator Superfamily
C2H83_RS19905	COG0697	spore germination
C2H83_RS19910	COG1464	Belongs to the NlpA lipoprotein family
C2H83_RS19940	COG2252	PERMEase
C2H83_RS19950	COG2271	Major facilitator Superfamily
C2H83_RS19955	COG2271	Major facilitator Superfamily
C2H83_RS19960	COG3851	Histidine kinase
C2H83_RS19965	COG2197	response regulator
C2H83_RS19970	COG0440	acetolactate synthase activity
C2H83_RS19975	COG0028	Belongs to the TPP enzyme family
C2H83_RS20005	COG2814	Major facilitator Superfamily
C2H83_RS20010	COG0641	radical SAM
C2H83_RS20020	COG2149	membrane
C2H83_RS20030	COG3119	arylsulfatase activity
C2H83_RS20035	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H83_RS20040	COG2207	Transcriptional regulator
C2H83_RS20055	COG2188	Transcriptional regulator
C2H83_RS20075	COG5645	(Lipo)protein
C2H83_RS20080	COG0823	Involved in the tonB-independent uptake of proteins
C2H83_RS20085	COG0644	oxidoreductase
C2H83_RS20090	COG2271	Major facilitator Superfamily
C2H83_RS20100	COG0800	Aldolase
C2H83_RS20105	COG3734	2-keto-3-deoxy-galactonokinase
C2H83_RS20110	COG2186	Transcriptional regulator
C2H83_RS20120	COG0561	phosphatase activity
C2H83_RS20125	COG3753	Protein conserved in bacteria
C2H83_RS20130	COG0187	DNA topoisomerase II activity
C2H83_RS20140	COG0592	DNA-directed DNA polymerase activity
C2H83_RS20190	COG0814	amino acid
C2H83_RS20205	COG2091	lysine biosynthetic process via aminoadipic acid
C2H83_RS20210	COG0431	NADPH-dependent FMN reductase
C2H83_RS20215	COG2252	PERMEase
C2H83_RS20220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H83_RS20230	COG3196	Protein conserved in bacteria
C2H83_RS20235	COG0363	glucosamine-6-phosphate deaminase activity
C2H83_RS20240	COG2382	esterase
C2H83_RS20250	COG2723	6-phospho-beta-galactosidase activity
C2H83_RS20255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS20255	COG1263	PTS System
C2H83_RS20255	COG2190	(PTS) system
C2H83_RS20260	COG3711	transcriptional antiterminator
C2H83_RS20265	COG0704	Plays a role in the regulation of phosphate uptake
C2H83_RS20270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H83_RS20275	COG0581	inorganic phosphate transmembrane transporter activity
C2H83_RS20280	COG0573	inorganic phosphate transmembrane transporter activity
C2H83_RS20285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H83_RS20290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H83_RS20340	COG3312	ion transport
C2H83_RS20355	COG0716	FMN binding
C2H83_RS20360	COG1522	sequence-specific DNA binding
C2H83_RS20390	COG1129	ABC transporter
C2H83_RS20395	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS20400	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS20405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS20410	COG1609	Transcriptional regulator
C2H83_RS20415	COG0477	Major facilitator Superfamily
C2H83_RS20420	COG2186	Transcriptional regulator
C2H83_RS20460	COG3085	chromosome segregation
C2H83_RS20465	COG0606	chelatase, subunit chli
C2H83_RS20490	COG3978	acetolactate synthase activity
C2H83_RS20495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H83_RS20505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H83_RS20510	COG0583	DNA-binding transcription factor activity
C2H83_RS20520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H83_RS20530	COG0210	DNA helicase
C2H83_RS20550	COG3118	belongs to the thioredoxin family
C2H83_RS20560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2H83_RS20570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H83_RS20575	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2H83_RS20580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2H83_RS20585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2H83_RS20590	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H83_RS20595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H83_RS20600	COG0456	acetyltransferase
C2H83_RS20605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H83_RS20610	COG2244	polysaccharide biosynthetic process
C2H83_RS20630	COG1113	amino acid transport
C2H83_RS20655	COG0641	radical SAM
C2H83_RS20660	COG3119	arylsulfatase activity
C2H83_RS20665	COG3071	HemY protein
C2H83_RS20670	COG2959	enzyme of heme biosynthesis
C2H83_RS20675	COG1587	Uroporphyrinogen-III synthase
C2H83_RS20690	COG3072	Adenylate cyclase
C2H83_RS20700	COG5567	small periplasmic lipoprotein
C2H83_RS20710	COG3159	Protein conserved in bacteria
C2H83_RS20720	COG1011	Hydrolase
C2H83_RS20725	COG0210	DNA helicase
C2H83_RS20730	COG3698	Phosphodiester glycosidase
C2H83_RS20735	COG0598	Magnesium transport protein CorA
C2H83_RS20750	COG2962	Rard protein
C2H83_RS20755	COG2050	protein possibly involved in aromatic compounds catabolism
C2H83_RS20760	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C2H83_RS20765	COG0514	ATP-dependent DNA helicase (RecQ)
C2H83_RS20770	COG1280	lysine exporter protein (LysE YggA)
C2H83_RS20775	COG1280	lysine exporter protein (LysE YggA)
C2H83_RS20780	COG2267	carboxylic ester hydrolase activity
C2H83_RS20785	COG0561	phosphatase activity
C2H83_RS20790	COG0697	spore germination
C2H83_RS20795	COG0583	DNA-binding transcription factor activity
C2H83_RS20805	COG0412	Dienelactone hydrolase
C2H83_RS20810	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2H83_RS20820	COG1322	Protein conserved in bacteria
C2H83_RS20830	COG3165	ubiquinone biosynthetic process from chorismate
C2H83_RS20840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H83_RS20845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H83_RS20850	COG0805	protein transport
C2H83_RS20855	COG0084	hydrolase, TatD family'
C2H83_RS20860	COG0250	Participates in transcription elongation, termination and antitermination
C2H83_RS20865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2H83_RS20870	COG0543	2 iron, 2 sulfur cluster binding
C2H83_RS20875	COG0183	Belongs to the thiolase family
C2H83_RS20890	COG1739	Uncharacterized protein family UPF0029
C2H83_RS20895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H83_RS20900	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2H83_RS20930	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H83_RS20935	COG0746	molybdenum cofactor guanylyltransferase activity
C2H83_RS20940	COG3084	Protein conserved in bacteria
C2H83_RS20945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H83_RS20950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H83_RS20955	COG5339	Protein conserved in bacteria
C2H83_RS20960	COG0204	Acyl-transferase
C2H83_RS20970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H83_RS20970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H83_RS20985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H83_RS20995	COG2204	response regulator
C2H83_RS21000	COG3852	Histidine kinase
C2H83_RS21005	COG0174	glutamine synthetase
C2H83_RS21015	COG1217	gtp-binding protein TYPA
C2H83_RS21020	COG2188	Transcriptional regulator
C2H83_RS21025	COG1082	Xylose isomerase domain protein TIM barrel
C2H83_RS21030	COG2271	Major facilitator Superfamily
C2H83_RS21035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2H83_RS21040	COG2211	Major facilitator Superfamily
C2H83_RS21045	COG2211	Major facilitator Superfamily
C2H83_RS21050	COG1501	Belongs to the glycosyl hydrolase 31 family
C2H83_RS21055	COG2017	converts alpha-aldose to the beta-anomer
C2H83_RS21060	COG2942	2-epimerase
C2H83_RS21065	COG3684	Belongs to the aldolase LacD family
C2H83_RS21070	COG2084	Dehydrogenase
C2H83_RS21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H83_RS21080	COG1349	DNA-binding transcription factor activity
C2H83_RS21085	COG1011	Hydrolase
C2H83_RS21100	COG0456	acetyltransferase
C2H83_RS21105	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2H83_RS21110	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2H83_RS21120	COG2864	formate dehydrogenase
C2H83_RS21125	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS21150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS21150	COG3711	transcriptional antiterminator
C2H83_RS21155	COG1363	Peptidase, m42
C2H83_RS21160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS21160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS21165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS21205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H83_RS21220	COG2258	MOSC domain
C2H83_RS21225	COG2205	protein histidine kinase activity
C2H83_RS21230	COG0745	RESPONSE REGULATOR receiver
C2H83_RS21235	COG3678	ATP-independent chaperone mediated protein folding
C2H83_RS21250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2H83_RS21270	COG3152	Membrane
C2H83_RS21275	COG3691	Protein conserved in bacteria
C2H83_RS21280	COG0589	response to stress
C2H83_RS21285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H83_RS21290	COG1494	fructose-1,6-bisphosphatase
C2H83_RS21300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H83_RS21315	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H83_RS21330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H83_RS21335	COG1609	Transcriptional regulator
C2H83_RS21340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H83_RS21350	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2H83_RS21360	COG0626	cystathionine gamma-synthase activity
C2H83_RS21365	COG0460	homoserine dehydrogenase
C2H83_RS21365	COG0527	aspartate kinase activity
C2H83_RS21370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H83_RS21380	COG0697	spore germination
C2H83_RS21385	COG3738	Protein conserved in bacteria
C2H83_RS21390	COG0371	Dehydrogenase
C2H83_RS21395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H83_RS21400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H83_RS21400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS21400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS21405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS21410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS21415	COG1882	Formate acetyltransferase
C2H83_RS21420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2H83_RS21425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H83_RS21430	COG2207	Transcriptional regulator
C2H83_RS21435	COG2194	sulfuric ester hydrolase activity
C2H83_RS21455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H83_RS21470	COG0583	DNA-binding transcription factor activity
C2H83_RS21500	COG4206	TonB-dependent receptor
C2H83_RS21530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2H83_RS21535	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2H83_RS21535	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2H83_RS21580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H83_RS21585	COG0250	Participates in transcription elongation, termination and antitermination
C2H83_RS21630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2H83_RS21640	COG2104	thiamine diphosphate biosynthetic process
C2H83_RS21645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H83_RS21680	COG3068	Protein conserved in bacteria
C2H83_RS21695	COG3678	ATP-independent chaperone mediated protein folding
C2H83_RS21705	COG4191	Histidine kinase
C2H83_RS21710	COG2204	response regulator
C2H83_RS21715	COG0151	Belongs to the GarS family
C2H83_RS21755	COG0456	acetyltransferase
C2H83_RS21765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2H83_RS21770	COG2224	Isocitrate lyase
C2H83_RS21785	COG1414	Transcriptional regulator
C2H83_RS21790	COG1410	methionine synthase
C2H83_RS21790	COG0646	methionine synthase
C2H83_RS21795	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H83_RS21805	COG1187	pseudouridine synthase activity
C2H83_RS21815	COG0527	aspartate kinase activity
C2H83_RS21850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H83_RS21865	COG2814	Major facilitator Superfamily
C2H83_RS21865	COG0477	Major facilitator Superfamily
C2H83_RS21870	COG3833	ABC-type maltose transport systems, permease component
C2H83_RS21875	COG1175	transmembrane transport
C2H83_RS21880	COG2182	Extracellular solute-binding protein
C2H83_RS21890	COG3842	ATPase activity
C2H83_RS21910	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H83_RS21935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H83_RS21945	COG0534	Mate efflux family protein
C2H83_RS21950	COG3237	CsbD-like
C2H83_RS21955	COG0735	belongs to the Fur family
C2H83_RS21970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H83_RS21980	COG0604	alcohol dehydrogenase
C2H83_RS21985	COG0305	Participates in initiation and elongation during chromosome replication
C2H83_RS21990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H83_RS21995	COG1448	Aminotransferase
C2H83_RS22005	COG3700	Belongs to the class B bacterial acid phosphatase family
C2H83_RS22010	COG0432	Pfam Uncharacterised protein family UPF0047
C2H83_RS22015	COG2315	Protein conserved in bacteria
C2H83_RS22020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H83_RS22025	COG0629	single-stranded DNA binding
C2H83_RS22040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2H83_RS22045	COG2207	Transcriptional regulator
C2H83_RS22050	COG0789	Transcriptional regulator
C2H83_RS22070	COG2252	PERMEase
C2H83_RS22075	COG0025	NhaP-type Na H and K H
C2H83_RS22080	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H83_RS22090	COG3162	membrane
C2H83_RS22095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H83_RS22110	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2H83_RS22115	COG0437	4 iron, 4 sulfur cluster binding
C2H83_RS22120	COG3301	Polysulphide reductase, NrfD
C2H83_RS22125	COG1138	Cytochrome C-type biogenesis protein
C2H83_RS22130	COG3088	subunit of a heme lyase
C2H83_RS22135	COG4235	cytochrome complex assembly
C2H83_RS22145	COG1301	dicarboxylic acid transport
C2H83_RS22150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2H83_RS22160	COG1538	Outer membrane efflux protein
C2H83_RS22165	COG1289	transmembrane transporter activity
C2H83_RS22170	COG1566	PFAM secretion protein HlyD family protein
C2H83_RS22180	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2H83_RS22185	COG1940	carbohydrate kinase activity
C2H83_RS22190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H83_RS22195	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS22200	COG1129	ABC transporter
C2H83_RS22205	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS22210	COG1737	Transcriptional regulator
C2H83_RS22220	COG0698	ribose 5-phosphate isomerase
C2H83_RS22230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H83_RS22235	COG0456	acetyltransferase
C2H83_RS22240	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C2H83_RS22245	COG3454	Phosphonate metabolism
C2H83_RS22250	COG4778	phosphonate C-P lyase system protein PhnL
C2H83_RS22255	COG4107	phosphonate C-P lyase system protein PhnK
C2H83_RS22260	COG3627	carbon phosphorus lyase activity
C2H83_RS22265	COG3626	phosphonate metabolism
C2H83_RS22270	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2H83_RS22275	COG3624	Phosphonate C-P lyase system protein PhnG
C2H83_RS22280	COG2188	Transcriptional regulator
C2H83_RS22290	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2H83_RS22295	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2H83_RS22300	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C2H83_RS22305	COG2824	Alkylphosphonate utilization operon protein PhnA
C2H83_RS22315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H83_RS22325	COG0477	Major facilitator Superfamily
C2H83_RS22335	COG0642	Histidine kinase
C2H83_RS22340	COG0745	RESPONSE REGULATOR receiver
C2H83_RS22345	COG2194	sulfuric ester hydrolase activity
C2H83_RS22350	COG0531	amino acid
C2H83_RS22355	COG2207	Transcriptional regulator
C2H83_RS22360	COG1982	Orn Lys Arg decarboxylase major
C2H83_RS22365	COG2169	Transcriptional regulator
C2H83_RS22370	COG1486	melibiose metabolic process
C2H83_RS22375	COG2211	Major facilitator Superfamily
C2H83_RS22380	COG3647	Membrane
C2H83_RS22385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C2H83_RS22385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2H83_RS22390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2H83_RS22400	COG4565	transcriptional regulatory protein
C2H83_RS22405	COG3290	protein histidine kinase activity
C2H83_RS22410	COG3592	Divergent 4Fe-4S mono-cluster
C2H83_RS22415	COG2388	GCN5-related N-acetyl-transferase
C2H83_RS22435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H83_RS22440	COG3104	oligopeptide transport
C2H83_RS22445	COG1982	Orn Lys Arg decarboxylase major
C2H83_RS22450	COG0531	amino acid
C2H83_RS22455	COG3710	Transcriptional regulator
C2H83_RS22470	COG1309	transcriptional regulator
C2H83_RS22475	COG4232	protein-disulfide reductase activity
C2H83_RS22485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2H83_RS22490	COG1027	Aspartate ammonia-lyase
C2H83_RS22495	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H83_RS22500	COG0531	amino acid
C2H83_RS22525	COG1509	lysine 2,3-aminomutase activity
C2H83_RS22535	COG5510	response to toxic substance
C2H83_RS22540	COG5510	response to toxic substance
C2H83_RS22545	COG2076	Multidrug Resistance protein
C2H83_RS22550	COG3040	lipid binding
C2H83_RS22555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H83_RS22570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H83_RS22575	COG1053	succinate dehydrogenase
C2H83_RS22585	COG0531	amino acid
C2H83_RS22600	COG3264	Mechanosensitive ion channel
C2H83_RS22600	COG1511	domain protein
C2H83_RS22640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2H83_RS22645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2H83_RS22645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2H83_RS22650	COG0802	atpase or kinase
C2H83_RS22655	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H83_RS22675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H83_RS22680	COG0330	HflC and HflK could
C2H83_RS22685	COG0330	HflC and HflK could
C2H83_RS22690	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2H83_RS22705	COG0557	exoribonuclease II activity
C2H83_RS22710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H83_RS22720	COG3789	protein conserved in bacteria
C2H83_RS22725	COG1842	Phage shock protein A
C2H83_RS22735	COG3766	membrane
C2H83_RS22740	COG5463	Belongs to the UPF0441 family
C2H83_RS22745	COG0754	glutathionylspermidine amidase activity
C2H83_RS22750	COG1960	acyl-CoA dehydrogenase activity
C2H83_RS22765	COG3650	response to hydrogen peroxide
C2H83_RS22770	COG1073	alpha beta
C2H83_RS22785	COG3037	sugar-specific permease SgaT UlaA
C2H83_RS22790	COG3414	Phosphotransferase system galactitol-specific IIB component
C2H83_RS22795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS22830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H83_RS22850	COG1309	transcriptional regulator
C2H83_RS22855	COG3061	Opacity-associated protein A
C2H83_RS22865	COG0545	Peptidyl-prolyl cis-trans isomerase
C2H83_RS22870	COG1113	amino acid transport
C2H83_RS22880	COG0697	spore germination
C2H83_RS22885	COG0702	epimerase
C2H83_RS22890	COG1733	regulation of RNA biosynthetic process
C2H83_RS22895	COG0737	Belongs to the 5'-nucleotidase family
C2H83_RS22900	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2H83_RS22915	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2H83_RS22925	COG1253	flavin adenine dinucleotide binding
C2H83_RS22940	COG0729	surface antigen
C2H83_RS22945	COG2911	Protein conserved in bacteria
C2H83_RS22950	COG2105	PFAM AIG2 family protein
C2H83_RS22955	COG2336	PFAM SpoVT AbrB
C2H83_RS22960	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H83_RS22965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2H83_RS22970	COG1879	ABC-type sugar transport system periplasmic component
C2H83_RS22975	COG1129	ABC transporter
C2H83_RS22980	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS22985	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H83_RS22995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H83_RS23005	COG0312	modulator of DNA gyrase
C2H83_RS23010	COG3783	Cytochrome b(562)
C2H83_RS23015	COG0602	queuosine metabolic process
C2H83_RS23020	COG1328	CTP reductase activity
C2H83_RS23025	COG0366	Alpha amylase catalytic
C2H83_RS23030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H83_RS23030	COG1263	PTS System
C2H83_RS23035	COG1609	Transcriptional regulator
C2H83_RS23045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H83_RS23050	COG0251	oxidation-reduction process
C2H83_RS23075	COG0251	oxidation-reduction process
C2H83_RS23080	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS23085	COG1309	transcriptional regulator
C2H83_RS23090	COG2731	YhcH YjgK YiaL family protein
C2H83_RS23100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H83_RS23105	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2H83_RS23110	COG0456	acetyltransferase
C2H83_RS23115	COG4269	membrane
C2H83_RS23120	COG0525	valine-tRNA ligase activity
C2H83_RS23125	COG2927	DNA polymerase III (CHI subunit)
C2H83_RS23135	COG0795	lipopolysaccharide-transporting ATPase activity
C2H83_RS23140	COG0795	lipopolysaccharide-transporting ATPase activity
C2H83_RS23145	COG0433	COG0433 Predicted ATPase
C2H83_RS23150	COG1609	Transcriptional regulator
C2H83_RS23155	COG2610	gluconate transmembrane transporter activity
C2H83_RS23160	COG1028	Short-chain dehydrogenase reductase Sdr
C2H83_RS23165	COG1063	alcohol dehydrogenase
C2H83_RS23170	COG3265	gluconokinase activity
C2H83_RS23175	COG1064	alcohol dehydrogenase
C2H83_RS23190	COG0582	viral genome integration into host DNA
C2H83_RS23225	COG3385	transposase activity
C2H83_RS23230	COG2814	Major facilitator Superfamily
C2H83_RS23235	COG0673	inositol 2-dehydrogenase activity
C2H83_RS23260	COG2826	transposase and inactivated derivatives, IS30 family
C2H83_RS23275	COG2085	NADP oxidoreductase coenzyme F420-dependent
C2H83_RS23280	COG1120	ATPase activity
C2H83_RS23285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H83_RS23290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H83_RS23295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H83_RS23300	COG4772	TonB-dependent receptor
C2H83_RS23305	COG3712	iron ion homeostasis
C2H83_RS23310	COG1595	DNA-templated transcription, initiation
C2H83_RS23325	COG2390	Transcriptional regulator
C2H83_RS23335	COG2610	gluconate transmembrane transporter activity
C2H83_RS23340	COG0129	dihydroxy-acid dehydratase activity
C2H83_RS23345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H83_RS23350	COG1414	Transcriptional regulator
C2H83_RS23355	COG1349	DNA-binding transcription factor activity
C2H83_RS23360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H83_RS23365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H83_RS23370	COG0434	BtpA family
C2H83_RS23375	COG3775	system Galactitol-specific IIC component
C2H83_RS23380	COG3414	Phosphotransferase system galactitol-specific IIB component
C2H83_RS23385	COG1363	Peptidase, m42
C2H83_RS23395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H83_RS23400	COG3153	acetyltransferase
C2H83_RS23425	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2H83_RS23425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H83_RS23435	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
C2H83_RS23440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2H83_RS23455	COG0582	viral genome integration into host DNA
C2H83_RS23460	COG4974	Belongs to the 'phage' integrase family
C2H83_RS23470	COG3539	Fimbrial protein
C2H83_RS23475	COG3539	Fimbrial protein
C2H83_RS23480	COG3121	Chaperone
C2H83_RS23485	COG3188	usher protein
C2H83_RS23490	COG3539	Fimbrial protein
C2H83_RS23495	COG3539	Fimbrial protein
C2H83_RS23500	COG3539	Fimbrial protein
C2H83_RS23505	COG2610	gluconate transmembrane transporter activity
C2H83_RS23520	COG0246	Mannitol dehydrogenase
C2H83_RS23530	COG2186	Transcriptional regulator
C2H83_RS23550	COG0583	DNA-binding transcription factor activity
C2H83_RS23555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H83_RS23560	COG0700	Nucleoside recognition
C2H83_RS23565	COG3366	ferrous iron transmembrane transporter activity
C2H83_RS23580	COG0477	Major facilitator Superfamily
C2H83_RS23585	COG3204	pilus organization
C2H83_RS23595	COG1924	4 iron, 4 sulfur cluster binding
C2H83_RS23600	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2H83_RS23605	COG2733	membrane
C2H83_RS23610	COG2814	Major facilitator Superfamily
C2H83_RS23625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H83_RS23630	COG5457	Domain of unknown function (DUF1127)
C2H83_RS23640	COG1196	nuclear chromosome segregation
C2H83_RS23650	COG4268	DNA restriction-modification system
C2H83_RS23655	COG1401	restriction endodeoxyribonuclease activity
C2H83_RS23665	COG0732	type I restriction modification DNA specificity domain
C2H83_RS23670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2H83_RS23675	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C2H83_RS23680	COG1715	Restriction endonuclease
C2H83_RS23685	COG0523	cobalamin synthesis protein
C2H83_RS23690	COG2879	small protein
C2H83_RS23695	COG1966	Carbon starvation protein
C2H83_RS23705	COG0840	transmembrane signaling receptor activity
C2H83_RS23710	COG2271	Major facilitator Superfamily
C2H83_RS23715	COG1802	Transcriptional regulator
C2H83_RS23720	COG1063	alcohol dehydrogenase
C2H83_RS23735	COG1484	DNA-dependent DNA replication
C2H83_RS23750	COG2966	Psort location CytoplasmicMembrane, score
C2H83_RS23755	COG2197	response regulator
C2H83_RS23760	COG2197	response regulator
C2H83_RS23765	COG4114	ferric iron reductase
C2H83_RS23795	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C2H83_RS23800	COG0456	acetyltransferase
C2H83_RS23805	COG1011	Hydrolase
C2H83_RS23815	COG2823	Periplasmic or secreted lipoprotein
C2H83_RS23825	COG4667	esterase of the alpha-beta hydrolase superfamily
C2H83_RS23830	COG0084	hydrolase, TatD family'
C2H83_RS23835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2H83_RS23840	COG1328	CTP reductase activity
C2H83_RS23865	COG3550	peptidyl-serine autophosphorylation
C2H83_RS23875	COG3726	membrane protein affecting hemolysin expression
C2H83_RS23880	COG0560	Phosphoserine phosphatase
C2H83_RS23885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H83_RS23890	COG1056	cytidyltransferase-related domain
C2H83_RS23890	COG3172	ATPase kinase involved in NAD metabolism
C2H83_RS23895	COG0488	(ABC) transporter
C2H83_RS23905	COG0741	lytic transglycosylase activity
C2H83_RS23925	COG3708	Transcriptional regulator
C2H83_RS23925	COG2207	Transcriptional regulator
C2H83_RS23930	COG3045	CreA protein
C2H83_RS23935	COG0745	RESPONSE REGULATOR receiver
C2H83_RS23940	COG2205	protein histidine kinase activity
C2H83_RS23945	COG4452	Inner membrane protein CreD
C2H83_RS23950	COG0745	RESPONSE REGULATOR receiver
C2H83_RS23960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA