locus-tag class description HP432_RS00005 ENOG4108BUD transposase HP432_RS00110 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HP432_RS00120 ENOG4105EKQ RNA-directed DNA polymerase HP432_RS00130 ENOG4105DPW Major facilitator superfamily MFS_1 HP432_RS00140 ENOG4105DEI Mannitol dehydrogenase HP432_RS00150 ENOG4105C6F GntR Family Transcriptional Regulator HP432_RS00175 ENOG4108BUD transposase HP432_RS00190 ENOG4108MY7 Fimbrial HP432_RS00195 ENOG4108TTM chaperone HP432_RS00215 ENOG4108KTG Membrane protein, drug metabolite transporter HP432_RS00240 ENOG4108BUD transposase HP432_RS00250 ENOG4108BUD transposase HP432_RS00265 ENOG4108BUD transposase HP432_RS00310 ENOG4107QMH DNA methylase HP432_RS00315 ENOG4107J0C type IIi HP432_RS00330 ENOG4108BUD transposase HP432_RS00345 ENOG4108BUD transposase HP432_RS00375 ENOG4105K4U addiction module toxin, RelE StbE family HP432_RS00410 ENOG4107QJE Chromosome Partitioning Protein HP432_RS00435 ENOG41060ND LF82 chromosome, complete sequence HP432_RS00515 ENOG4105EMU Dehydrogenase HP432_RS00525 ENOG4108BUD transposase HP432_RS00540 ENOG4108BUD transposase HP432_RS00565 ENOG4108BUD transposase HP432_RS00585 ENOG4105DR5 peptidase HP432_RS00615 ENOG410624V efflux system protein HP432_RS00650 ENOG4105BZU Histidine kinase HP432_RS00670 ENOG4105F9F transposase HP432_RS00690 ENOG4107QN2 dihydrolipoyl dehydrogenase HP432_RS00700 ENOG4108YXQ IS66 Orf2 family protein HP432_RS00765 ENOG4108YXQ IS66 Orf2 family protein HP432_RS00775 ENOG4105DIJ Phosphoethanolamine transferase HP432_RS00780 ENOG41080IJ Diacylglycerol kinase HP432_RS00805 ENOG4108BUD transposase HP432_RS00825 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HP432_RS00845 ENOG4108BUD transposase HP432_RS00860 ENOG4108BUD transposase HP432_RS00890 ENOG4108BUD transposase HP432_RS00945 ENOG4108TTM chaperone HP432_RS00950 ENOG4108MY7 Fimbrial HP432_RS00960 ENOG4105PV3 Inner membrane protein yqiJ HP432_RS00965 ENOG4107S78 Band 7 protein HP432_RS00985 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HP432_RS00990 ENOG4105I7R Adenylate cyclase HP432_RS00995 ENOG4106MWK domain protein HP432_RS01010 ENOG4107ZVW dihydroneopterin aldolase HP432_RS01020 ENOG4105EJC lysr family transcriptional regulator HP432_RS01025 ENOG4106DSS Tartrate dehydratase subunit alpha HP432_RS01030 ENOG4107GFK fumarate HP432_RS01035 ENOG4107QPK )-transporter HP432_RS01040 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HP432_RS01050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HP432_RS01055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP432_RS01070 ENOG4105Q26 Siderophore-interacting protein HP432_RS01075 ENOG4105NTW Transcriptional regulator HP432_RS01080 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HP432_RS01085 ENOG4105C8Y Acetylornithine aminotransferase HP432_RS01090 ENOG4108Y51 tRNA-binding protein HP432_RS01095 ENOG4105CQ4 Transcriptional regulator HP432_RS01100 ENOG4105CNT hydrolase family 2 HP432_RS01105 ENOG4105FK9 beta-D-galactosidase beta subunit HP432_RS01110 ENOG4105E5D amino acid HP432_RS01115 ENOG4107W6W Conserved Protein HP432_RS01120 ENOG4107WCA isomerase HP432_RS01125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HP432_RS01135 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HP432_RS01140 ENOG4108VKG metal-dependent hydrolase HP432_RS01145 ENOG4108UB4 uncharacterized protein ygjQ HP432_RS01150 ENOG4105EE0 oxidoreductase HP432_RS01155 ENOG4105DU1 integral membrane protein, terc HP432_RS01160 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HP432_RS01165 ENOG4105P66 Membrane HP432_RS01170 ENOG4105CTX dehydratase HP432_RS01180 ENOG4105DPW Major facilitator superfamily MFS_1 HP432_RS01185 ENOG4107YCY Transcriptional regulator HP432_RS01190 ENOG4106W5V Membrane HP432_RS01195 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HP432_RS01200 ENOG4105WAY exported protein HP432_RS01205 ENOG4105NE1 Conserved Protein HP432_RS01210 ENOG41090KG Inner membrane protein YqjE HP432_RS01215 ENOG4105YJD HP432_RS01220 ENOG4108VBZ doxx family HP432_RS01225 ENOG4105CHF Glutathione S-transferase HP432_RS01230 ENOG4105KAF membrAne HP432_RS01235 ENOG4105KAF membrAne HP432_RS01240 ENOG4105CWB LysR family transcriptional Regulator HP432_RS01245 ENOG4108CNN domain protein HP432_RS01250 ENOG4106D80 Uncharacterized protein YhaL HP432_RS01260 ENOG4105C44 Serine transporter HP432_RS01265 ENOG4105EJQ L-serine dehydratase HP432_RS01270 ENOG4105KME endoribonuclease L-psp HP432_RS01275 ENOG4105C6N Formate acetyltransferase HP432_RS01280 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HP432_RS01285 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HP432_RS01290 ENOG4105C7B Threonine dehydratase HP432_RS01295 ENOG410811B TRANSCRIPTIONal HP432_RS01320 ENOG4105BZW Glycerate kinase HP432_RS01325 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HP432_RS01335 ENOG4105DJB Major Facilitator Superfamily HP432_RS01340 ENOG4105CTX dehydratase HP432_RS01345 ENOG4105ZEG Suppressor protein HP432_RS01365 ENOG4105E98 transcriptional regulator DeoR family HP432_RS01370 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HP432_RS01375 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HP432_RS01385 ENOG4105F3R pts system mannose fructose sorbose family iid HP432_RS01390 ENOG4108YTN IIa component HP432_RS01400 ENOG4105E70 isomerase HP432_RS01410 ENOG4108UZY PTS System HP432_RS01415 ENOG4105ETZ PTS System HP432_RS01420 ENOG4105F3R pts system mannose fructose sorbose family iid HP432_RS01425 ENOG4106HBN Galactosamine-6-phosphate isomerase HP432_RS01430 ENOG4105Q10 Fimbrial-like protein HP432_RS01435 ENOG4108VCD Chaperone HP432_RS01440 ENOG4105CW0 outer membrane usher protein HP432_RS01445 ENOG4105I74 Fimbrial protein HP432_RS01450 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HP432_RS01455 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HP432_RS01470 ENOG4105W4M Transport-associated protein HP432_RS01475 ENOG4107S21 permease HP432_RS01480 ENOG4105K4T epimerase HP432_RS01485 ENOG4107R7Y intracellular protease Pfpi family HP432_RS01500 ENOG4108YYD acetyltransferase HP432_RS01520 ENOG4105DEN Luciferase family HP432_RS01525 ENOG4105CIC tryptophan-specific transport protein HP432_RS01530 ENOG4105C1J atp-dependent rna helicase HP432_RS01570 ENOG4105CHV Transcription elongation factor NusA HP432_RS01590 ENOG4105DIJ Phosphoethanolamine transferase HP432_RS01600 ENOG4105NTZ Preprotein translocase subunit SecG HP432_RS01610 ENOG4105EEI dihydropteroate synthase HP432_RS01615 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HP432_RS01625 ENOG4105HBR Rna-binding protein HP432_RS01630 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HP432_RS01635 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HP432_RS01645 ENOG4105QYV Membrane HP432_RS01660 ENOG4105EAH synthase HP432_RS01665 ENOG4105HVQ Regulatory factor of maltose metabolism HP432_RS01675 ENOG4105VFK BolA family HP432_RS01680 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HP432_RS01685 ENOG4105E3I toluene tolerance HP432_RS01690 ENOG4107PE3 Mammalian cell entry related domain protein HP432_RS01695 ENOG4105CY3 ABC transporter, permease HP432_RS01700 ENOG4105DHJ ABC, transporter HP432_RS01705 ENOG4105FEU K -dependent Na -Ca exchanger HP432_RS01710 ENOG4105C2X Arabinose 5-phosphate isomerase HP432_RS01720 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HP432_RS01725 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HP432_RS01730 ENOG4108IUZ ABC transporter HP432_RS01735 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP432_RS01740 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HP432_RS01745 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HP432_RS01755 ENOG41080Z8 PHOSPHOCARRIER protein HP432_RS01760 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HP432_RS01770 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HP432_RS01775 ENOG4105BZU Histidine kinase HP432_RS01780 ENOG4105N5T Radical SAM Protein HP432_RS01785 ENOG4105CBC glutamate synthase HP432_RS01790 ENOG4105BZ8 glutamate synthase HP432_RS01795 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HP432_RS01800 ENOG4108S1B Periplasmic chaperone protein HP432_RS01805 ENOG4105E6S usher protein( HP432_RS01815 ENOG4105UMR response to DNA damage stimulus HP432_RS01830 ENOG4105DFS Conserved Protein HP432_RS01835 ENOG4108R66 Conserved Protein HP432_RS01840 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HP432_RS01850 ENOG4105JHE Major Facilitator Superfamily HP432_RS01860 ENOG4108QBF Transcriptional regulator HP432_RS01865 ENOG4105CEE C4-dicarboxylate transporter HP432_RS01870 ENOG4105KB2 stringent starvation protein b HP432_RS01875 ENOG4107MKT Stringent starvation protein a HP432_RS01890 ENOG4105D6Z AFG1 family ATPase HP432_RS01895 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HP432_RS01900 ENOG4105C0H protease HP432_RS01905 ENOG4105C0H protease HP432_RS01920 ENOG4105RID UPF0379 protein yhcN HP432_RS01925 ENOG4105UNR (Barnase) inhibitor HP432_RS01940 ENOG4105ZQC membrane protein AaeX HP432_RS01945 ENOG4105CR8 Transcriptional regulator HP432_RS01950 ENOG4105D1U peptidase U62 modulator of DNA gyrase HP432_RS01955 ENOG4105QD6 exported protein HP432_RS01960 ENOG4105C03 ribonuclease HP432_RS01970 ENOG4105VQ7 Rod shape-determining protein MreD HP432_RS01975 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HP432_RS01985 ENOG41062P1 Diguanylate cyclase phosphodiesterase HP432_RS01990 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HP432_RS01995 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HP432_RS02000 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HP432_RS02005 ENOG4105RG0 Membrane HP432_RS02010 ENOG4108IA2 Sodium pantothenate symporter HP432_RS02020 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HP432_RS02030 ENOG4105CEC DNA methylase N-4 N-6 HP432_RS02035 ENOG41061ME transport protein HP432_RS02040 ENOG4108XG4 DNA-binding transcriptional regulator HP432_RS02045 ENOG4105C1P efflux transporter, rnd family, mfp subunit HP432_RS02050 ENOG4105BZS acriflavin resistance protein HP432_RS02055 ENOG4105XCM membrane LIPOPROTEIN HP432_RS02065 ENOG4105EZ7 amino acid ABC transporter HP432_RS02070 ENOG4105DRP amino acid AbC transporter HP432_RS02075 ENOG4105CDA abc transporter atp-binding protein HP432_RS02110 ENOG4108Z0R Transferase HP432_RS02115 ENOG4105SG3 Protein of unknown function (DUF1488) HP432_RS02130 ENOG4108WI1 Dna topoisomerase HP432_RS02140 ENOG4105C79 DNA protecting protein DprA HP432_RS02160 ENOG4105C1A potassium transporter peripheral membrane HP432_RS02170 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HP432_RS02175 ENOG4105W1Y Transcriptional regulator HP432_RS02180 ENOG4105VTS DnaJ-like, subfamily C HP432_RS02210 ENOG41067V7 50S ribosomal protein L36 HP432_RS02215 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HP432_RS02260 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HP432_RS02305 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HP432_RS02325 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HP432_RS02330 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HP432_RS02335 ENOG4107KSE General secretion pathway protein C HP432_RS02340 ENOG4105GVR general secretion pathway protein D HP432_RS02345 ENOG4107QHF type ii secretion system protein e HP432_RS02350 ENOG4105D7Q type ii secretion system HP432_RS02355 ENOG4108VAU general secretion pathway protein G HP432_RS02360 ENOG41069X0 general secretion pathway protein h HP432_RS02375 ENOG4105R04 type II secretion system protein K HP432_RS02380 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HP432_RS02390 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HP432_RS02395 ENOG4108UQY Iron-storage protein HP432_RS02400 ENOG4105W53 bacterioferritin-associated ferredoxin HP432_RS02405 ENOG4108NNZ chitinase HP432_RS02430 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HP432_RS02435 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HP432_RS02440 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HP432_RS02445 ENOG4105WWK YheO domain protein HP432_RS02450 ENOG4108V1T peptidylprolyl cis-trans isomerase HP432_RS02460 ENOG4108YZY peptidylprolyl cis-trans isomerase HP432_RS02465 ENOG4105VKU nucleicacid-binding protein HP432_RS02480 ENOG4105C5H ABC transporter HP432_RS02485 ENOG4105DNZ Alpha Beta Hydrolase HP432_RS02495 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HP432_RS02500 ENOG4108UKZ OsmC family HP432_RS02510 ENOG410613R integral membrane protein, YccS YhfK family HP432_RS02515 ENOG4105C8Y Acetylornithine aminotransferase HP432_RS02520 ENOG4105DDQ anthranilate synthase HP432_RS02525 ENOG4105MZU cell filamentation protein HP432_RS02535 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HP432_RS02545 ENOG4107QZF nitrite reductase NADPH large subunit HP432_RS02550 ENOG4105WZK nitrite reductase NADPH small subunit HP432_RS02555 ENOG4107V9H nitrite transporter HP432_RS02565 ENOG4105VYH HP432_RS02570 ENOG4107QHQ amino acid HP432_RS02575 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HP432_RS02580 ENOG4107Y0V Not clear, may be involved in an isomerization step HP432_RS02585 ENOG4108KPW sugar kinase HP432_RS02590 ENOG4105FDP GntR family transcriptional regulator HP432_RS02595 ENOG4106PKC pyridoxal phosphate binding HP432_RS02600 ENOG4106M0N transport system permease protein HP432_RS02605 ENOG4105MUZ Protein of unknown function DUF2620 HP432_RS02610 ENOG41080QX K07048 phosphotriesterase-related protein HP432_RS02615 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HP432_RS02620 ENOG4108626 Racemase HP432_RS02625 ENOG4105RMW regulation of transcription, DNA-dependent HP432_RS02630 ENOG4108M21 HP432_RS02635 ENOG4105C31 Tryptophanyl-tRNA synthetase HP432_RS02640 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HP432_RS02645 ENOG4105DJV ribulose-phosphate 3-epimerase HP432_RS02650 ENOG4105DFE Dna adenine methylase HP432_RS02655 ENOG4105EGB membrane protein DamX HP432_RS02670 ENOG4105E4G Type IV pilus HP432_RS02675 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HP432_RS02680 ENOG4105XPX DNA utilization protein HofO HP432_RS02685 ENOG41065NF Fimbrial assembly family protein HP432_RS02690 ENOG4108U1Q Pilus assembly protein HP432_RS02695 ENOG4108JQC penicillin-binding protein 1A HP432_RS02700 ENOG4107RK2 ADP-ribose diphosphatase NudE HP432_RS02705 ENOG4105DQY intracellular growth attenuator HP432_RS02710 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HP432_RS02715 ENOG4105VEJ Heat shock protein HP432_RS02725 ENOG4108MAJ Membrane HP432_RS02735 ENOG4105E0F Histidine kinase HP432_RS02745 ENOG4108RRZ Transcription elongation factor GreB HP432_RS02750 ENOG4105BZM domain protein HP432_RS02755 ENOG4105XFK Ferrous iron transport protein A HP432_RS02760 ENOG4105CE1 Ferrous iron transport protein b HP432_RS02770 ENOG4105DNE Transposase HP432_RS02785 ENOG4105MJ2 Competence protein HP432_RS02795 ENOG4105C6Z Gluconate HP432_RS02800 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HP432_RS02805 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HP432_RS02820 ENOG4105E0Y RtcB Protein HP432_RS02825 ENOG4105CYB regulatoR HP432_RS02830 ENOG4105E98 transcriptional regulator DeoR family HP432_RS02845 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HP432_RS02870 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HP432_RS02895 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HP432_RS02900 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HP432_RS02905 ENOG4105C6Z Gluconate HP432_RS02910 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HP432_RS02915 ENOG4105DIQ Transcriptional regulator HP432_RS02920 ENOG4105C2I pirin domain protein HP432_RS02925 ENOG4105D9R oxidoreductase HP432_RS02930 ENOG4105WCN acetyltransferase HP432_RS02935 ENOG4105GMB type VI secretion system effector, hcp1 family HP432_RS02950 ENOG4106FA4 HP432_RS02955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HP432_RS02960 ENOG4105WC8 Conserved Protein HP432_RS02965 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HP432_RS02970 ENOG4108IJ9 (ABC) transporter HP432_RS02975 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HP432_RS02980 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HP432_RS02985 ENOG4105BZ7 extracellular solute-binding protein family 1 HP432_RS02990 ENOG4108IV0 ABC, transporter HP432_RS02995 ENOG4105C0Z ABC transporter HP432_RS03000 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HP432_RS03005 ENOG4105C32 Amino acid ABC transporter (Permease) HP432_RS03010 ENOG4105CP9 extracellular ligand-binding receptor HP432_RS03015 ENOG4105U59 -acetyltransferase HP432_RS03020 ENOG4105CP9 extracellular ligand-binding receptor HP432_RS03025 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP432_RS03030 ENOG4105CRP Part of the ABC transporter FtsEX involved in HP432_RS03035 ENOG4105CAK Cell division ATP-binding protein ftsE HP432_RS03040 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HP432_RS03045 ENOG4106H78 methyltransferase HP432_RS03050 ENOG4105MG3 Membrane HP432_RS03060 ENOG4107FS9 Membrane HP432_RS03075 ENOG4105EX9 Membrane HP432_RS03080 ENOG4108W1V Lipoprotein HP432_RS03085 ENOG4105F9N Major Facilitator Superfamily HP432_RS03090 ENOG4105DSF transport protein HP432_RS03095 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HP432_RS03100 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HP432_RS03105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP432_RS03110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP432_RS03115 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HP432_RS03120 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HP432_RS03130 ENOG4105CNA YD repeat protein HP432_RS03140 ENOG4105NUP lyase containing HEAT-repeat HP432_RS03145 ENOG410600T transposase HP432_RS03150 ENOG4105CMI transporter HP432_RS03155 ENOG4105CJ1 ABC, transporter HP432_RS03160 ENOG4105D0S secretion protein (HlyD HP432_RS03175 ENOG4107UNS conserved inner membrane protein HP432_RS03180 ENOG4105CBX hi0933 family HP432_RS03185 ENOG4105CJ3 phosphate transporter HP432_RS03200 ENOG4105DUX Transporter HP432_RS03210 ENOG4105DGW oligopeptidase A HP432_RS03215 ENOG4105D6S protein involved in catabolism of external DNA HP432_RS03220 ENOG4105DC8 reductase HP432_RS03230 ENOG4105KBH arsR family transcriptional regulator HP432_RS03235 ENOG4107R5R arsenical pump membrane protein HP432_RS03240 ENOG4105K89 arsenate reductase HP432_RS03250 ENOG4105Y4Z Outer Membrane Lipoprotein HP432_RS03260 ENOG4105KT7 mgtC SapB transporter HP432_RS03265 ENOG4105XXV Acid-resistance protein HP432_RS03270 ENOG41060V2 Acid-resistance protein HP432_RS03275 ENOG4108YK4 Acid-resistance membrane protein HP432_RS03280 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HP432_RS03290 ENOG4105C1P efflux transporter, rnd family, mfp subunit HP432_RS03295 ENOG4105BZS acriflavin resistance protein HP432_RS03305 ENOG4108NKV transcriptional regulator HP432_RS03310 ENOG4105CVK Glutamate decarboxylase HP432_RS03315 ENOG4105CA0 peroxidase HP432_RS03325 ENOG4106S2D Transcriptional regulator HP432_RS03330 ENOG4105CBN LysR family transcriptional regulator HP432_RS03335 ENOG4107H3J ribonuclease HP432_RS03340 ENOG4105CSH Transporter HP432_RS03345 ENOG41066T0 asmA family HP432_RS03350 ENOG4105CMB EAL domain-containing protein HP432_RS03360 ENOG4105CS0 peptidase HP432_RS03370 ENOG4105BZU Histidine kinase HP432_RS03380 ENOG4105WQA Cellulose biosynthesis protein BcsF HP432_RS03385 ENOG4105D1V cellulose synthase operon protein YhjU HP432_RS03395 ENOG4105C44 Serine transporter HP432_RS03400 ENOG4108JQ7 (ABC) transporter HP432_RS03405 ENOG4105C3U ABC transporter HP432_RS03410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP432_RS03415 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP432_RS03420 ENOG4105DEF Extracellular solute-binding protein, family 5 HP432_RS03430 ENOG4105DIJ Phosphoethanolamine transferase HP432_RS03435 ENOG4105FCD Major Facilitator HP432_RS03440 ENOG4105EAX Putative lipase HP432_RS03445 ENOG4108R3E Dna-3-methyladenine glycosylase i HP432_RS03450 ENOG4105HNP -acetyltransferase HP432_RS03455 ENOG4107QY8 reductase HP432_RS03460 ENOG4108ZG0 Ompa motb domain protein HP432_RS03465 ENOG4105C5I Dehydrogenase HP432_RS03470 ENOG4106JH6 (LipO)protein HP432_RS03475 ENOG4105MVF Transcriptional regulator HP432_RS03485 ENOG41060TC Hok gef cell toxic protein HP432_RS03505 ENOG4105RGS lipoprotein ysaB HP432_RS03510 ENOG4105MEV Acyl-transferase HP432_RS03515 ENOG4108Z12 YiaAB two helix domain-containing protein HP432_RS03525 ENOG410688U Inner membrane protein yiaB HP432_RS03530 ENOG4105CMG Carbohydrate kinase HP432_RS03540 ENOG4105DFW ABC transporter HP432_RS03545 ENOG4105C2J ABC transporter HP432_RS03550 ENOG4108HWW ABC transporter HP432_RS03555 ENOG4105T16 Transcriptional regulator (AraC family) HP432_RS03560 ENOG4108UR8 BAX protein HP432_RS03565 ENOG4107T9C Alpha amylase catalytic region HP432_RS03570 ENOG4105JKW Valine--pyruvate aminotransferase HP432_RS03575 ENOG4108XIB electron transport protein ysaA HP432_RS03580 ENOG4105J4Q Transcriptional regulator HP432_RS03590 ENOG4108R66 Conserved Protein HP432_RS03595 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HP432_RS03600 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HP432_RS03605 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HP432_RS03610 ENOG4105CMG Carbohydrate kinase HP432_RS03615 ENOG4105H6Q decarboxylase HP432_RS03620 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HP432_RS03625 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HP432_RS03630 ENOG4105GNX MltA-interacting MipA family protein HP432_RS03635 ENOG4108Q2M Transcriptional regulator HP432_RS03640 ENOG4105EFX secretion protein, HlyD family HP432_RS03645 ENOG4105KK7 inner membrane protein YiaW HP432_RS03655 ENOG4105C26 Dehydrogenase HP432_RS03660 ENOG4105C0A alcohol dehydrogenase HP432_RS03665 ENOG4105EM7 Selenocysteine-specific translation elongation factor HP432_RS03675 ENOG4108U78 Glutathione S-transferase HP432_RS03690 ENOG4105EFX secretion protein, HlyD family HP432_RS03695 ENOG4105FP6 Protein of unknown function (DUF3302) HP432_RS03700 ENOG4105CTS PTS system mannitol-specific HP432_RS03710 ENOG4105E61 Mannitol repressor protein HP432_RS03720 ENOG4108YYI Protein of unknown function (DUF2810) HP432_RS03725 ENOG4105DAA L-lactate HP432_RS03730 ENOG41073TP transcriptional regulator HP432_RS03740 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HP432_RS03745 ENOG4105D7W serine acetyltransferase HP432_RS03760 ENOG4105VW4 glutaredoxin 3 HP432_RS03765 ENOG4107YZP Rhodanese domain protein HP432_RS03770 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HP432_RS03775 ENOG41063SB peptidase HP432_RS03780 ENOG4105PXI polysaccharide deacetylase HP432_RS03785 ENOG4105K64 Glycosyl transferase, family 2 HP432_RS03790 ENOG4105CPQ Dehydrogenase HP432_RS03795 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HP432_RS03800 ENOG4108SEH involved in lipopolysaccharide biosynthesis HP432_RS03815 ENOG4105XA0 heptosyltransferase ii HP432_RS03820 ENOG4105D16 lipopolysaccharide heptosyltransferase i HP432_RS03825 ENOG4108FRV O-antigen ligase HP432_RS03830 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HP432_RS03835 ENOG4105X1N Glycosyl transferase family 8 HP432_RS03840 ENOG4108PDR lipopolysaccharide core biosynthesis protein HP432_RS03845 ENOG4106AH0 Glycosyl Transferase HP432_RS03850 ENOG4107543 (lipo)polysaccharide HP432_RS03855 ENOG4107RJ7 Glycosyl transferase (Group 1 HP432_RS03860 ENOG4105DKP glycosyl transferase, family 9 HP432_RS03865 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HP432_RS03885 ENOG4105KDC 50s ribosomal protein l28 HP432_RS03895 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HP432_RS03900 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HP432_RS03920 ENOG4105DSJ YicC domain protein HP432_RS03960 ENOG4105YB8 TM2 domain containing protein HP432_RS03980 ENOG4105F5P DNA-damage-inducible protein d HP432_RS03985 ENOG4105EN6 Membrane HP432_RS03990 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HP432_RS03995 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HP432_RS04005 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HP432_RS04010 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HP432_RS04015 ENOG4105CB5 ATP-dependent DNA helicase recG HP432_RS04020 ENOG4105D6U Sodium Glutamate Symporter HP432_RS04025 ENOG4105C2W permease HP432_RS04030 ENOG4105JV1 AsmA family HP432_RS04035 ENOG4105CJQ hydrolase, family 31 HP432_RS04045 ENOG4105CT4 transporter HP432_RS04060 ENOG4105S8Q sugar efflux transporter HP432_RS04065 ENOG4108UZ3 Transporter HP432_RS04070 ENOG4105D01 (LipO)protein HP432_RS04075 ENOG4105T8A Uncharacterized protein YicS HP432_RS04085 ENOG4108SAJ Protein of unknown function (DUF1198) HP432_RS04090 ENOG4105C7N Xanthine uracil vitamin C permease HP432_RS04095 ENOG4105CPN adenine deaminase HP432_RS04100 ENOG4105CXY transporter HP432_RS04105 ENOG4105CXY transporter HP432_RS04110 ENOG4105BZU Histidine kinase HP432_RS04115 ENOG4108KX4 response regulator HP432_RS04120 ENOG4105M71 acetolactate synthase 1 regulatory subunit HP432_RS04125 ENOG4105C7K acetolactate synthase HP432_RS04140 ENOG4105E5M Multidrug resistance protein D HP432_RS04145 ENOG4105J13 transcriptional regulator HP432_RS04150 ENOG4105JP4 Inner membrane protein yidG HP432_RS04155 ENOG4105VG5 Membrane HP432_RS04160 ENOG4106DRA Inner membrane protein YidI HP432_RS04165 ENOG4105CBG Sulfatase HP432_RS04170 ENOG4107RUZ Sss sodium solute transporter superfamily HP432_RS04175 ENOG4108AHD Transcriptional regulator HP432_RS04190 ENOG4105FDP GntR family transcriptional regulator HP432_RS04210 ENOG4105R2A (LipO)protein HP432_RS04215 ENOG4105D99 atp gtp-binding protein HP432_RS04225 ENOG4105DJB Major Facilitator Superfamily HP432_RS04235 ENOG4108RTU Aldolase HP432_RS04240 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HP432_RS04245 ENOG4105EMF GntR family transcriptional regulator HP432_RS04250 ENOG410657R replicase EC 2.7 HP432_RS04255 ENOG410667J hydrolase HP432_RS04265 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP432_RS04275 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HP432_RS04290 ENOG4105VG0 50S ribosomal protein l34 HP432_RS04305 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HP432_RS04310 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HP432_RS04325 ENOG4108P6C Tryptophan transporter of low affinity HP432_RS04330 ENOG4105CNH Multidrug resistance protein MdtL HP432_RS04340 ENOG4105E8Q phosphopantetheinyl transferase HP432_RS04345 ENOG4108YYH Nadph-dependent fmn reductase HP432_RS04350 ENOG4105C7N Xanthine uracil vitamin C permease HP432_RS04355 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HP432_RS04370 ENOG4106611 bacteriocin immunity HP432_RS04375 ENOG4107VKM 6-phosphogluconolactonase HP432_RS04380 ENOG4105DYC esterase HP432_RS04390 ENOG4105CS2 ec 3.2.1.21 HP432_RS04395 ENOG4105C5Y PTS System HP432_RS04400 ENOG4105F9F transposase HP432_RS04415 ENOG4105F9F transposase HP432_RS04420 ENOG4108UTW Plays a role in the regulation of phosphate uptake HP432_RS04425 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HP432_RS04430 ENOG4105E2Z phosphate ABC transporter (Permease HP432_RS04435 ENOG4105C8U phosphate abc transporter HP432_RS04440 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HP432_RS04445 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HP432_RS04480 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HP432_RS04495 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HP432_RS04510 ENOG4105QTB Flavodoxin HP432_RS04515 ENOG4108VVK transcriptional Regulator, AsnC HP432_RS04525 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HP432_RS04540 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HP432_RS04545 ENOG4105C2J ABC transporter HP432_RS04550 ENOG4105CNN ABC, transporter HP432_RS04555 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HP432_RS04560 ENOG4108RVA ribokinase HP432_RS04565 ENOG4105ETE Transcriptional regulator (LacI family HP432_RS04570 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP432_RS04575 ENOG4107EJG GntR family transcriptional regulator HP432_RS04615 ENOG4108WFC UPF0438 protein yifE HP432_RS04620 ENOG4105C0P Mg chelatase subunit ChlI HP432_RS04640 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HP432_RS04645 ENOG4105CM2 brancheD-chain amino acid aminotransferase HP432_RS04655 ENOG4105C7B Threonine dehydratase HP432_RS04660 ENOG4105EMY transcriptional regulator HP432_RS04670 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HP432_RS04680 ENOG4105C4R Atp-dependent dna helicase HP432_RS04705 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HP432_RS04710 ENOG4105ESV Glycosyl transferase, family 4 HP432_RS04715 ENOG4105SFE lipopolysaccharide biosynthesis protein HP432_RS04720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HP432_RS04725 ENOG4107QQG Dehydrogenase HP432_RS04730 ENOG4105C1B dTDP-glucose 4-6-dehydratase HP432_RS04735 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HP432_RS04740 ENOG4108WJ1 acetyltransferase HP432_RS04745 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HP432_RS04750 ENOG4105EGZ biosynthesis protein HP432_RS04755 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HP432_RS04770 ENOG4105C85 amino acid HP432_RS04795 ENOG4105C4X radical SAM domain protein HP432_RS04800 ENOG4105ENH Sulfatase HP432_RS04805 ENOG410601J HemY protein HP432_RS04810 ENOG4105ECF c-methyltransferase HP432_RS04815 ENOG41076E6 Uroporphyrinogen-III Synthase HP432_RS04820 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HP432_RS04825 ENOG4107T0K Adenylate cyclase HP432_RS04865 ENOG4105S7Z (LipO)protein HP432_RS04875 ENOG4105CT0 Protein of unknown function, DUF484 HP432_RS04885 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HP432_RS04890 ENOG4105C4R Atp-dependent dna helicase HP432_RS04895 ENOG4108T58 Mg2 transport protein CorA HP432_RS04900 ENOG4107QUT magnesium and cobalt transport protein CorA HP432_RS04905 ENOG4105NRM Membrane HP432_RS04910 ENOG4106WR8 Inner membrane protein YigG HP432_RS04915 ENOG4105FR1 rard protein HP432_RS04920 ENOG4108VUY thioesterase Superfamily protein HP432_RS04925 ENOG4105HDD phospholipase HP432_RS04930 ENOG4105C9U ATP-dependent DNA helicase RecQ HP432_RS04935 ENOG4105CCF Lysine exporter protein (Lyse ygga) HP432_RS04940 ENOG410829K Lysine exporter protein (Lyse ygga) HP432_RS04945 ENOG4108EUD Lysophospholipase HP432_RS04950 ENOG4105DQF Hydrolase HP432_RS04955 ENOG4105EMK carboxylate amino acid amine transporter HP432_RS04960 ENOG4105DZ2 Transcriptional regulator HP432_RS04965 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HP432_RS04970 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HP432_RS04975 ENOG4108I5U Uridine phosphorylase HP432_RS04980 ENOG4105CGY Dna recombination protein HP432_RS04990 ENOG4105JC1 sterol-binding domain protein HP432_RS05000 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HP432_RS05005 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HP432_RS05010 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HP432_RS05015 ENOG4105F8V Hydrolase, tatD family HP432_RS05020 ENOG4105MDZ Transcriptional activator rfaH HP432_RS05025 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HP432_RS05030 ENOG4108EX3 reductase HP432_RS05035 ENOG4105CHU acetyl-coa acetyltransferase HP432_RS05040 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HP432_RS05050 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HP432_RS05055 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HP432_RS05060 ENOG4108RR8 protoporphyrinogen oxidase HP432_RS05090 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HP432_RS05095 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HP432_RS05100 ENOG4105PC1 Conserved Protein HP432_RS05105 ENOG4105E27 serine threonine protein kinase HP432_RS05110 ENOG4108Z33 Thiol disulfide Interchange Protein HP432_RS05120 ENOG4106HNH Acyl-transferase HP432_RS05125 ENOG4105C2M dna polymerase I HP432_RS05140 ENOG4105D4P Coproporphyrinogen iii oxidase HP432_RS05145 ENOG4106FIY HP432_RS05150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HP432_RS05155 ENOG4105CUX Signal transduction histidine kinase HP432_RS05160 ENOG4105C5F glutamine synthetase HP432_RS05165 ENOG4105CI3 gtp-binding protein typa HP432_RS05170 ENOG4108K85 Transcriptional regulator HP432_RS05175 ENOG4108KHF Resistance protein HP432_RS05185 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HP432_RS05190 ENOG4105CT4 transporter HP432_RS05195 ENOG4105CT4 transporter HP432_RS05200 ENOG4105CJQ hydrolase, family 31 HP432_RS05205 ENOG4107WI4 Aldose-1-epimerase HP432_RS05210 ENOG4107QKS N-acylglucosamine 2-epimerase HP432_RS05215 ENOG4105D2M Aldolase HP432_RS05220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HP432_RS05225 ENOG4108MGF sugar kinase HP432_RS05230 ENOG4105E98 transcriptional regulator DeoR family HP432_RS05235 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HP432_RS05250 ENOG4105SUU thioesterase domain HP432_RS05260 ENOG41068KX affects formate dehydrogenase-N HP432_RS05270 ENOG4108MG3 formate dehydrogenase HP432_RS05275 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP432_RS05285 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HP432_RS05290 ENOG4108V87 frv operon regulatory protein HP432_RS05295 ENOG4106C3V frv operon regulatory protein HP432_RS05300 ENOG4105CN9 Peptidase m42 family protein HP432_RS05305 ENOG4105DM4 PTS System HP432_RS05310 ENOG41064BA PTS system, fructose-specific, IIA component HP432_RS05325 ENOG4105DKG l-rhamnose isomerase HP432_RS05330 ENOG4105DET Rhamnulokinase HP432_RS05350 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HP432_RS05360 ENOG4108RPX mosc domain containing protein HP432_RS05365 ENOG4105E0F Histidine kinase HP432_RS05370 ENOG4105E3W Two component transcriptional regulator (Winged helix family HP432_RS05375 ENOG4105FMW periplasmic HP432_RS05390 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HP432_RS05405 ENOG4105EBK exported protein HP432_RS05410 ENOG4108VTS Membrane HP432_RS05415 ENOG41065TG regulatoR HP432_RS05425 ENOG4105DP0 ferredoxin-NADP reductase HP432_RS05430 ENOG4105CBT Fructose-1,6-bisphosphatase HP432_RS05440 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HP432_RS05455 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HP432_RS05470 ENOG41063M6 Cell Division Protein HP432_RS05475 ENOG4105ETE Transcriptional regulator (LacI family HP432_RS05480 ENOG4105C25 Primosomal protein n' HP432_RS05490 ENOG4107S01 Repressor protein MetJ HP432_RS05500 ENOG4105C28 cystathionine HP432_RS05505 ENOG4105CFH Aspartokinase HP432_RS05510 ENOG4105SYT Methylenetetrahydrofolate reductase HP432_RS05520 ENOG4108Q5Y Membrane HP432_RS05525 ENOG4108XC3 NADH ubiquinone oxidoreductase HP432_RS05530 ENOG4105DCT glycerol dehydrogenase HP432_RS05535 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP432_RS05540 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HP432_RS05545 ENOG4105DM4 PTS System HP432_RS05550 ENOG4108YRF PTS System HP432_RS05560 ENOG4108AHH pyruvate formate lyase II activase HP432_RS05565 ENOG4108XCZ PTS System HP432_RS05570 ENOG4106R3P AraC family transcriptional regulator HP432_RS05575 ENOG4105DIJ Phosphoethanolamine transferase HP432_RS05585 ENOG4105CWC Acetylornithine deacetylase HP432_RS05590 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HP432_RS05605 ENOG4105C5Q Transcriptional regulator HP432_RS05615 ENOG4105EJ2 Transcriptional regulator HP432_RS05620 ENOG4108Y73 Membrane HP432_RS05630 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HP432_RS05635 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HP432_RS05660 ENOG4105D4A Cell wall formation (By similarity) HP432_RS05665 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HP432_RS05700 ENOG4105PM1 preprotein translocase subunit SecE HP432_RS05705 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HP432_RS05740 ENOG410645W Thiamin biosynthesis protein ThiH HP432_RS05745 ENOG4105D41 biosynthesis protein thiH HP432_RS05750 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HP432_RS05755 ENOG4105WHD thiamine biosynthesis protein ThiS HP432_RS05760 ENOG4105D06 uba thif-type nad fad binding protein HP432_RS05795 ENOG4105R2J Conserved Protein HP432_RS05805 ENOG4108T8B Protein of unknown function (DUF1481) HP432_RS05810 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HP432_RS05815 ENOG4105BZU Histidine kinase HP432_RS05820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HP432_RS05825 ENOG4105C12 Phosphoribosylglycinamide synthetase HP432_RS05855 ENOG4105K5X acetyltransferase HP432_RS05865 ENOG4107QP3 malate synthase g HP432_RS05870 ENOG4108I9X Isocitrate lyase HP432_RS05875 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HP432_RS05885 ENOG41069M3 Transcriptional regulator HP432_RS05890 ENOG4105C3R Methionine synthase HP432_RS05895 ENOG4105EAM Na Pi-cotransporter HP432_RS05905 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HP432_RS05910 ENOG4105F3R pts system mannose fructose sorbose family iid HP432_RS05915 ENOG4105ETZ PTS System HP432_RS05920 ENOG4105KPI PTS system sorbose subfamily IIB component HP432_RS05925 ENOG4108XCU pts system HP432_RS05930 ENOG4105CHR reductase HP432_RS05935 ENOG4105DKT Transcriptional regulator HP432_RS05940 ENOG4105FE9 pseudouridine synthase HP432_RS05945 ENOG4108ZR5 Conserved Protein HP432_RS05950 ENOG4105CFH Aspartokinase HP432_RS05955 ENOG4107QP8 phosphohexose isomerase HP432_RS05965 ENOG4108MDC (LipO)protein HP432_RS05970 ENOG4108Q9C Periplasmic Protein HP432_RS05975 ENOG4105E3R (LipO)protein HP432_RS05995 ENOG4107QNK )-transporter HP432_RS06000 ENOG4105EG2 ABC transporter, permease HP432_RS06005 ENOG4105D56 permease protein HP432_RS06010 ENOG4107FKK extracellular solute-binding protein family 1 HP432_RS06015 ENOG4108IJ9 (ABC) transporter HP432_RS06025 ENOG4107W52 maltose operon periplasmic protein HP432_RS06050 ENOG41080IJ Diacylglycerol kinase HP432_RS06060 ENOG4107R73 Mate efflux family protein HP432_RS06065 ENOG4105VDW Csbd family HP432_RS06070 ENOG4105MYN Zinc uptake regulation protein HP432_RS06080 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HP432_RS06085 ENOG4105P4Z Phage shock protein G HP432_RS06090 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HP432_RS06095 ENOG4105CDU Replicative dna helicase HP432_RS06100 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HP432_RS06105 ENOG4105CGF Aromatic amino acid aminotransferase HP432_RS06130 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HP432_RS06135 ENOG4105MSB protein, conserved in bacteria HP432_RS06140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HP432_RS06145 ENOG4108UUM single-stranded DNA-binding protein HP432_RS06150 ENOG4105PMV Membrane HP432_RS06155 ENOG4108M8H domain protein HP432_RS06160 ENOG4108W3Q Transcriptional regulator HP432_RS06165 ENOG4108Z4X TRANSCRIPTIONal HP432_RS06170 ENOG4105C7N Xanthine uracil vitamin C permease HP432_RS06175 ENOG4105EEQ Na H antiporter HP432_RS06200 ENOG41062QD Membrane HP432_RS06205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HP432_RS06215 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HP432_RS06220 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP432_RS06225 ENOG4105DVI reductase, NrfD HP432_RS06230 ENOG4108QKW cytochrome c-type biogenesis protein HP432_RS06240 ENOG4108W0S formate-dependent nitrite reductase complex HP432_RS06245 ENOG4105CK2 sodium dicarboxylate symporter HP432_RS06250 ENOG41082ND Uncharacterized protein yjcO HP432_RS06260 ENOG4105ETP RND efflux system, outer membrane lipoprotein HP432_RS06265 ENOG4108MI0 Resistance protein HP432_RS06270 ENOG4105J12 Multidrug resistance protein mdtN HP432_RS06275 ENOG4106833 HP432_RS06280 ENOG4105EUZ Beta-lactamase domain protein HP432_RS06285 ENOG4107TFG D-allose kinase HP432_RS06290 ENOG4105UP7 3-epimerase HP432_RS06295 ENOG4105CNN ABC, transporter HP432_RS06300 ENOG4105C2J ABC transporter HP432_RS06305 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HP432_RS06310 ENOG4105NYY transcriptional regulator, RpiR HP432_RS06315 ENOG4108YZG isomerase HP432_RS06325 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HP432_RS06330 ENOG410849A acetyltransferase, (GNAT) family HP432_RS06335 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HP432_RS06340 ENOG4105FD8 phosphonate metabolism protein PhnM HP432_RS06345 ENOG4105HRV phosphonate c-p lyase system protein phnl HP432_RS06350 ENOG4105ENV phosphonate C-P lyase system protein PhnK HP432_RS06355 ENOG4105FT8 Phosphonate metabolism HP432_RS06360 ENOG4105EKV Phosphonate metabolism protein HP432_RS06365 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HP432_RS06370 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HP432_RS06375 ENOG4107RJJ Transcriptional regulator HP432_RS06385 ENOG4105EHI Phosphonate ABC transporter, periplasmic HP432_RS06390 ENOG4105D5T phosphonate abc transporter HP432_RS06395 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HP432_RS06400 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HP432_RS06405 ENOG4108F5E vimentin HP432_RS06410 ENOG4108YIV HP432_RS06415 ENOG4105CSH Transporter HP432_RS06425 ENOG4105ECM Sensor protein basS pmrB HP432_RS06430 ENOG4105XJC Two component transcriptional regulator (Winged helix family HP432_RS06435 ENOG4105DIJ Phosphoethanolamine transferase HP432_RS06440 ENOG4105D5Q Arginine ornithine antiporter HP432_RS06445 ENOG4106ZGR Transcriptional regulator HP432_RS06450 ENOG4105CXN decarboxylase HP432_RS06455 ENOG4108K2B transcriptional regulator HP432_RS06460 ENOG4105F8D glycoside hydrolase family 4 HP432_RS06465 ENOG4105CT4 transporter HP432_RS06470 ENOG4108R5S membrane HP432_RS06475 ENOG4107GFK fumarate HP432_RS06480 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HP432_RS06485 ENOG4108MRH transcriptional regulatory protein HP432_RS06490 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HP432_RS06495 ENOG4105VR1 Pfam:DUF1271 HP432_RS06500 ENOG410830R acetyltransferase HP432_RS06515 ENOG4105CRK lysyL-tRNA synthetase HP432_RS06520 ENOG4105DUX Transporter HP432_RS06525 ENOG4105CXN decarboxylase HP432_RS06530 ENOG4105D5Q Arginine ornithine antiporter HP432_RS06535 ENOG4108M3R transcriptional activator CadC HP432_RS06545 ENOG4108SIC Transcriptional regulator HP432_RS06550 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HP432_RS06560 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HP432_RS06565 ENOG4108IJ0 Aspartate ammonia-lyase HP432_RS06570 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HP432_RS06575 ENOG4105DVH amino acid HP432_RS06590 ENOG4108ZVF (LipO)protein HP432_RS06600 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HP432_RS06610 ENOG4107PEH Entericidin EcnA/B family HP432_RS06615 ENOG4106BSU Entericidin B HP432_RS06620 ENOG4105KPY Small multidrug resistance protein HP432_RS06625 ENOG4105QNF Outer membrane lipoprotein HP432_RS06630 ENOG41066YJ Beta-lactamase HP432_RS06645 ENOG4105E33 succinate dehydrogenase HP432_RS06650 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HP432_RS06655 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HP432_RS06660 ENOG4107SC7 Inner membrane transporter yjeM HP432_RS06665 ENOG4106V5W HP432_RS06670 ENOG4106CG8 Inner membrane protein YjeO HP432_RS06675 ENOG4105EGS Mechanosensitive ion channel HP432_RS06715 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HP432_RS06720 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HP432_RS06725 ENOG4105K8N protein family UPF0079, ATPase HP432_RS06730 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HP432_RS06750 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HP432_RS06755 ENOG4107QJR hflk protein HP432_RS06760 ENOG4105EPW hflc protein HP432_RS06780 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HP432_RS06785 ENOG4105C2N RNA methyltransferase TrmH family group 3 HP432_RS06790 ENOG4105FUX Conserved Protein HP432_RS06795 ENOG4108P9J Phage shock protein A HP432_RS06800 ENOG4107VNS Protein of unknown function (DUF2491) HP432_RS06805 ENOG4105Z6B inner membrane protein yjfl HP432_RS06810 ENOG4108KXT Conserved Protein HP432_RS06815 ENOG4106032 Glutathionylspermidine synthase HP432_RS06820 ENOG4105CSU acyl-Coa dehydrogenase HP432_RS06825 ENOG4105S17 UPF0379 protein yjfN HP432_RS06830 ENOG4105WSB biofilm stress and motility protein A HP432_RS06835 ENOG4108MXZ Esterase HP432_RS06850 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HP432_RS06855 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HP432_RS06875 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HP432_RS06880 ENOG4105KIT UPF0379 protein yjfY HP432_RS06895 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HP432_RS06905 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HP432_RS06910 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HP432_RS06915 ENOG41069H7 transport system small permease component HP432_RS06920 ENOG4107S3R L-aspartate oxidase HP432_RS06925 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HP432_RS06930 ENOG4105E39 Enoyl-CoA hydratase HP432_RS06940 ENOG4105CHR reductase HP432_RS06950 ENOG4105FHY Opacity-associated protein A HP432_RS06955 ENOG4108V1T peptidylprolyl cis-trans isomerase HP432_RS06960 ENOG4105C85 amino acid HP432_RS06970 ENOG4105DXC membrane HP432_RS06975 ENOG4105ECR NmrA family HP432_RS06980 ENOG4105KVH Transcriptional regulator HP432_RS06985 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HP432_RS06990 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HP432_RS06995 ENOG4108UUE Transcriptional regulator HP432_RS07000 ENOG41061GZ Protein of unknown function (DUF1107) HP432_RS07005 ENOG4105C37 (CBS) domain HP432_RS07015 ENOG4105CFU surface antigen HP432_RS07020 ENOG4105MA0 exported protein HP432_RS07025 ENOG4108ZHD aig2 family HP432_RS07030 ENOG41087RY SpoVT_AbrB HP432_RS07035 ENOG4105MZG transcriptional modulator of maze toxin, mazf HP432_RS07040 ENOG4105F0N pyrophosphate phospho-hydrolase HP432_RS07045 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HP432_RS07050 ENOG4105C2J ABC transporter HP432_RS07055 ENOG4107R9N ABC transporter HP432_RS07060 ENOG41062B0 ABC transporter, permease HP432_RS07070 ENOG4105DFU Cell wall formation (By similarity) HP432_RS07080 ENOG4105CMS peptidase U62, modulator of DNA gyrase HP432_RS07085 ENOG4108XVM Cytochrome b(562) HP432_RS07090 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HP432_RS07095 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HP432_RS07100 ENOG4105CG3 alpha amylase, catalytic region HP432_RS07105 ENOG4105C5Y PTS System HP432_RS07110 ENOG4105D4X repressor HP432_RS07120 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HP432_RS07125 ENOG4105KME endoribonuclease L-psp HP432_RS07140 ENOG4107C93 pyrBI operon leader peptide HP432_RS07145 ENOG4108UQ8 endoribonuclease L-psp HP432_RS07150 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HP432_RS07155 ENOG4108XFH Transcriptional regulator HP432_RS07160 ENOG4105XEP YhcH YjgK YiaL family protein HP432_RS07175 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HP432_RS07180 ENOG4108MJ3 acetyltransferase HP432_RS07185 ENOG4108M3P Membrane HP432_RS07190 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HP432_RS07195 ENOG4105MYG DNA polymerase iii, chi subunit HP432_RS07205 ENOG4108M8S permease YjgP YjgQ family protein HP432_RS07210 ENOG4108K5H permease YjgP YjgQ family protein HP432_RS07220 ENOG4105DQ4 alcohol dehydrogenase HP432_RS07250 ENOG4105E3B Multicopper oxidase HP432_RS07270 ENOG4105C4R Atp-dependent dna helicase HP432_RS07295 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HP432_RS07300 ENOG4107EFN gluconate transport system permease 3 HP432_RS07310 ENOG4105DEI Mannitol dehydrogenase HP432_RS07315 ENOG4105C6F GntR Family Transcriptional Regulator HP432_RS07335 ENOG4107YNJ LysR family Transcriptional regulator HP432_RS07340 ENOG4105DYB Isoaspartyl dipeptidase HP432_RS07345 ENOG4108P2H Inner membrane protein YjiG HP432_RS07350 ENOG41074DU domain protein HP432_RS07360 ENOG4105CBP Major Facilitator HP432_RS07375 ENOG4105CIZ coA-substrate-specific enzyme activase HP432_RS07380 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HP432_RS07385 ENOG4106BRA Membrane HP432_RS07390 ENOG41083G8 Multidrug resistance protein MdtM HP432_RS07410 ENOG4105CKI cobalamin synthesis protein HP432_RS07415 ENOG4105VCD cytoplasmic protein HP432_RS07420 ENOG4105D22 carbon starvation protein HP432_RS07425 ENOG4105C8Q Methyl-accepting chemotaxis HP432_RS07430 ENOG4108I5G Major Facilitator superfamily HP432_RS07435 ENOG410617M Transcriptional regulator HP432_RS07440 ENOG4105CPQ Dehydrogenase HP432_RS07450 ENOG4105RI1 glycoprotein receptor HP432_RS07455 ENOG4106CVF DNA replication protein HP432_RS07470 ENOG4105DWK Membrane HP432_RS07475 ENOG4108N8T regulatoR HP432_RS07480 ENOG4108T94 DNA-binding transcriptional activator BglJ HP432_RS07485 ENOG4108819 ferric iron reductase HP432_RS07490 ENOG4105YBH Protein of unknown function (DUF1435) HP432_RS07510 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HP432_RS07515 ENOG4108WPU DNA polymerase III subunit psi HP432_RS07520 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HP432_RS07525 ENOG4105PAD Hydrolase HP432_RS07535 ENOG4105K3G Periplasmic Protein HP432_RS07545 ENOG4108NRW Phospholipase, patatin family HP432_RS07550 ENOG4105EYA deoxyribonuclease HP432_RS07555 ENOG41076CZ activating enzyme HP432_RS07560 ENOG4105G0K glycine radical enzyme YjjI family HP432_RS07595 ENOG41062Z9 Membrane HP432_RS07600 ENOG4105EAC phosphoserine phosphatase HP432_RS07605 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HP432_RS07610 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HP432_RS07620 ENOG4105C5H ABC transporter HP432_RS07625 ENOG4107SC1 transglycosylase HP432_RS07645 ENOG4105UEI Transcriptional Regulator AraC Family HP432_RS07650 ENOG4108RH0 Crea protein HP432_RS07655 ENOG4105E3W Two component transcriptional regulator (Winged helix family HP432_RS07660 ENOG4105EB3 Histidine kinase HP432_RS07665 ENOG4105CT7 inner membrane cred family protein HP432_RS07670 ENOG41065U4 response regulator HP432_RS07675 ENOG410759A HP432_RS07680 ENOG4106FVC RNA methyltransferase HP432_RS07690 ENOG4105CFH Aspartokinase HP432_RS07700 ENOG4105D98 threonine synthase HP432_RS07705 ENOG41062C6 Protein of unknown function (DUF2502) HP432_RS07715 ENOG4105BZG amino acid carrier protein HP432_RS07720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP432_RS07725 ENOG4108RIR Molybdenum cofactor biosynthesis protein HP432_RS07730 ENOG4106HK8 GPR1 FUN34 yaaH family protein HP432_RS07735 ENOG4108QUJ UPF0174 protein YaaW HP432_RS07755 ENOG4108SER Transposase HP432_RS07760 ENOG4105WI6 cell killing protein encoded within cryptic prophage HP432_RS07770 ENOG41063Z6 transcriptional regulator, lysR family HP432_RS07795 ENOG410647N response to DNA damage stimulus HP432_RS07800 ENOG4105DTN riboflavin biosynthesis protein ribF HP432_RS07805 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HP432_RS07810 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HP432_RS07815 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HP432_RS07825 ENOG4105DU0 nucleoside hydrolase HP432_RS07830 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HP432_RS07835 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HP432_RS07840 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HP432_RS07845 ENOG4108XNW Transcriptional activatory protein CaiF HP432_RS07850 ENOG4108Z0R Transferase HP432_RS07855 ENOG4106YT9 Enoyl-CoA hydratase HP432_RS07860 ENOG4105CEY Amp-dependent synthetase and ligase HP432_RS07865 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HP432_RS07895 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HP432_RS07900 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HP432_RS07905 ENOG4105C54 Major Facilitator superfamily HP432_RS07910 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HP432_RS07920 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HP432_RS07925 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HP432_RS07945 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HP432_RS07950 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HP432_RS07955 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HP432_RS07960 ENOG4105D3G Pseudouridine synthase HP432_RS07965 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HP432_RS07970 ENOG4105CQ2 DNA polymerase HP432_RS07975 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HP432_RS07990 ENOG41063TF transcriptional regulator (AraC HP432_RS07995 ENOG4108KF1 Membrane HP432_RS08005 ENOG4106SMU thiamine transporter membrane protein HP432_RS08010 ENOG4105DP9 ABC transporter HP432_RS08025 ENOG4105S8Q sugar efflux transporter HP432_RS08040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HP432_RS08055 ENOG41064T2 transcriptional regulator, lysR family HP432_RS08065 ENOG4105C7K acetolactate synthase HP432_RS08070 ENOG4108ZP8 Acetolactate synthase small subunit HP432_RS08080 ENOG4107B7Y DNA-binding transcriptional regulator FruR HP432_RS08085 ENOG4108V6E Cell division protein mraZ HP432_RS08095 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HP432_RS08100 ENOG4105CJN penicillin-binding protein HP432_RS08105 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HP432_RS08110 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HP432_RS08120 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HP432_RS08125 ENOG4105CNI cell division protein FtsW HP432_RS08130 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HP432_RS08135 ENOG4105DFU Cell wall formation (By similarity) HP432_RS08140 ENOG4105CPF Cell wall formation (By similarity) HP432_RS08145 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HP432_RS08150 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HP432_RS08155 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HP432_RS08165 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HP432_RS08175 ENOG4105M6F mutator MutT protein HP432_RS08190 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HP432_RS08200 ENOG4105D7Q type ii secretion system HP432_RS08205 ENOG4107QHF type ii secretion system protein e HP432_RS08210 ENOG4108ZUW Major pilin subunit HP432_RS08215 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HP432_RS08220 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HP432_RS08225 ENOG4106A72 regulatory protein AmpE HP432_RS08230 ENOG4105C85 amino acid HP432_RS08235 ENOG41073TP transcriptional regulator HP432_RS08240 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HP432_RS08245 ENOG4107QSN dihydrolipoamide acetyltransferase HP432_RS08250 ENOG4107QN2 dihydrolipoyl dehydrogenase HP432_RS08255 ENOG4108NST exported protein HP432_RS08260 ENOG4107QIJ Aconitate hydratase 2 HP432_RS08280 ENOG4108ZRK uncharacterized protein yacC HP432_RS08285 ENOG4105E3B Multicopper oxidase HP432_RS08290 ENOG4105DZG Dehydrogenase HP432_RS08295 ENOG4108UGV hypoxanthine phosphoribosyltransferase HP432_RS08300 ENOG41077A9 carbonic anhydrase HP432_RS08305 ENOG4105DA5 (ABC) transporter HP432_RS08310 ENOG4105E3A (ABC) transporter HP432_RS08315 ENOG4108YTN IIa component HP432_RS08320 ENOG4107BJW polysaccharide deacetylase HP432_RS08330 ENOG4108A32 Transposase HP432_RS08345 ENOG4105P0Q fimbrial-like protein YadC HP432_RS08355 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HP432_RS08360 ENOG4105DJ0 Poly(A) Polymerase HP432_RS08380 ENOG4107XID 2'-5' rna ligase HP432_RS08385 ENOG4105CQ7 ATP-dependent helicase HP432_RS08390 ENOG4105BZ4 penicillin-binding protein HP432_RS08395 ENOG4105E0K tonB-dependent siderophore receptor HP432_RS08400 ENOG4105E0A ABC, transporter HP432_RS08405 ENOG4105J76 Periplasmic binding protein HP432_RS08410 ENOG4105S6R Iron-hydroxamate transporter permease subunit HP432_RS08435 ENOG4105EN6 Membrane HP432_RS08440 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HP432_RS08455 ENOG4105C0H protease HP432_RS08460 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HP432_RS08470 ENOG4105DIN metallophosphoesterase HP432_RS08480 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HP432_RS08485 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HP432_RS08510 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HP432_RS08515 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HP432_RS08520 ENOG4105KNE Phosphatidate cytidylyltransferase HP432_RS08525 ENOG4105DZP Membrane-associated zinc metalloprotease HP432_RS08535 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HP432_RS08540 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HP432_RS08565 ENOG4105C0B DNA polymerase III (alpha subunit) HP432_RS08570 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HP432_RS08575 ENOG4105CXN decarboxylase HP432_RS08580 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HP432_RS08585 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HP432_RS08590 ENOG4105M1T rho-binding antiterminator HP432_RS08600 ENOG4108VWS Yaeq family HP432_RS08605 ENOG4108YZN class I peptide chain release factor HP432_RS08610 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HP432_RS08615 ENOG4108UY0 (LipO)protein HP432_RS08625 ENOG4108R96 Methyltransferase, YaeB family HP432_RS08630 ENOG4108R8X outer membrane lipoprotein HP432_RS08635 ENOG4105D01 (LipO)protein HP432_RS08640 ENOG4108UMI ABC transporter, permease HP432_RS08645 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HP432_RS08650 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HP432_RS08685 ENOG4105CV8 reductase HP432_RS08690 ENOG4105HEI LysR family (Transcriptional regulator HP432_RS08705 ENOG4105E9H Lytic Murein transglycosylase HP432_RS08710 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HP432_RS08715 ENOG4105D1A Methyltransferase HP432_RS08725 ENOG4107RZZ dna polymerase iii epsilon subunit HP432_RS08735 ENOG410600K aminopeptidase HP432_RS08750 ENOG4105GMB type VI secretion system effector, hcp1 family HP432_RS08780 ENOG4107TV1 YD repeat protein HP432_RS08790 ENOG410600T transposase HP432_RS08795 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HP432_RS08800 ENOG4108WN0 inhibitor of vertebrate lysozyme HP432_RS08805 ENOG4107QPN acyl-Coa dehydrogenase HP432_RS08815 ENOG4105E7A Glutamine amidotransferase HP432_RS08820 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HP432_RS08855 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HP432_RS08860 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HP432_RS08870 ENOG4108JIR Flagellum-specific ATP synthase HP432_RS08880 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HP432_RS08910 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HP432_RS08915 ENOG4108ZC9 flagellar basal-body rod protein flgc HP432_RS08925 ENOG4105BZE flagellar hook protein, FlgE HP432_RS08930 ENOG4108KPB Flagellar basal-body rod protein FlgF HP432_RS08935 ENOG4105CGA flagellar basal-body rod protein FlgG HP432_RS08950 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HP432_RS08960 ENOG4105DTJ flagellar hook-associated protein HP432_RS08975 ENOG4105I03 Flagellin HP432_RS08980 ENOG410804A Flagellar hook-associated 2 domain-containing protein HP432_RS09010 ENOG4107RD7 Flagellar Motor Protein, MotA HP432_RS09020 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HP432_RS09025 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HP432_RS09030 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HP432_RS09035 ENOG4108HYG acetyltransferase HP432_RS09045 ENOG4108S2Y peptide Chain Release factor HP432_RS09050 ENOG4105CIN aminoacyl-histidine dipeptidase HP432_RS09060 ENOG4105V1F Fermentation respiration switch protein HP432_RS09070 ENOG4105FCK Membrane HP432_RS09080 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HP432_RS09090 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HP432_RS09100 ENOG4105ZS6 Protein of unknown function (DUF987) HP432_RS09105 ENOG4108XS9 dna repair protein HP432_RS09110 ENOG4106549 Antirestriction protein HP432_RS09120 ENOG4106J9S Prophage HP432_RS09135 ENOG4108KZE transcriptional regulator HP432_RS09140 ENOG4106H6R UPF0380 protein HP432_RS09145 ENOG4108MXD gtp-binding protein HP432_RS09165 ENOG4108IQI permease HP432_RS09170 ENOG4107QK5 Homocysteine s-methyltransferase HP432_RS09175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HP432_RS09195 ENOG4108KBJ Inner membrane protein YkgB HP432_RS09200 ENOG41066GK UPF0379 protein ykgI HP432_RS09205 ENOG4107QN2 dihydrolipoyl dehydrogenase HP432_RS09210 ENOG4108K01 transcriptional regulator HP432_RS09215 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HP432_RS09220 ENOG4107QR9 Iron-sulfur cluster binding protein HP432_RS09225 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HP432_RS09235 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HP432_RS09240 ENOG4105C26 Dehydrogenase HP432_RS09245 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HP432_RS09250 ENOG4105C94 Transporter HP432_RS09265 ENOG4105BZU Histidine kinase HP432_RS09270 ENOG4108NUU Transcriptional regulator HP432_RS09275 ENOG4105SZ2 membrAne HP432_RS09280 ENOG4107SNB ankyrin repeat protein YahD HP432_RS09285 ENOG4105N16 Protein of unknown function (DUF2877) HP432_RS09290 ENOG4107R1Q Membrane protein FdrA HP432_RS09295 ENOG4107REC cytoplasmic protein HP432_RS09305 ENOG4105C5B carbamate kinase HP432_RS09310 ENOG4105DZC cytosine deaminase HP432_RS09315 ENOG4105DQ4 alcohol dehydrogenase HP432_RS09330 ENOG4105E82 cytochrome subunit of dehydrogenase HP432_RS09335 ENOG4105TDT uncharacterized protein yahO HP432_RS09340 ENOG4108JU7 Transcriptional regulator HP432_RS09345 ENOG4105CR4 methylisocitrate lyase HP432_RS09350 ENOG4105BZN citrate synthase HP432_RS09355 ENOG4105DXD 2-methylcitrate dehydratase HP432_RS09360 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HP432_RS09365 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HP432_RS09370 ENOG4105DZC cytosine deaminase HP432_RS09375 ENOG4105DND Transcriptional regulator HP432_RS09380 ENOG4107B2H carbonic anhydrase HP432_RS09385 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HP432_RS09390 ENOG4105DJ2 Major Facilitator Superfamily HP432_RS09395 ENOG4108UW5 maltose o-acetyltransferase HP432_RS09400 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HP432_RS09405 ENOG4105CNT hydrolase family 2 HP432_RS09410 ENOG4105ETE Transcriptional regulator (LacI family HP432_RS09415 ENOG4108K2P TRANSCRIPTIONal HP432_RS09435 ENOG4105IKQ hydratase HP432_RS09450 ENOG4108SC4 )-transporter HP432_RS09455 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HP432_RS09460 ENOG4105C4W S-formylglutathione hydrolase HP432_RS09475 ENOG4105SRB Uncharacterized protein yaiO HP432_RS09485 ENOG4108PBI Polysaccharide metabolism HP432_RS09490 ENOG4107W19 lmbE family HP432_RS09495 ENOG4106FTQ Taurine ABC transporter, periplasmic HP432_RS09500 ENOG4108ETV ABC transporter HP432_RS09505 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HP432_RS09510 ENOG4105E2B Taurine dioxygenase HP432_RS09515 ENOG4105D52 delta-aminolevulinic acid dehydratase HP432_RS09520 ENOG4108NSE outer membrane autotransporter barrel HP432_RS09535 ENOG4108PNB DNA-binding transcriptional regulator HP432_RS09540 ENOG4107R6D beta-lactam binding protein AmpH HP432_RS09545 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HP432_RS09550 ENOG4107QS8 (LipO)protein HP432_RS09555 ENOG4105FR5 inner membrane protein YaiY HP432_RS09560 ENOG4105UNH Membrane HP432_RS09565 ENOG4105CPF Cell wall formation (By similarity) HP432_RS09580 ENOG4105G6Z alkaline phosphatase HP432_RS09585 ENOG4105VIF phosphate starvation-inducible protein HP432_RS09590 ENOG4105BZU Histidine kinase HP432_RS09595 ENOG4105II7 pyrroline-5-carboxylate reductase HP432_RS09610 ENOG4105SS3 HP432_RS09615 ENOG4105HBA AroM protein HP432_RS09640 ENOG4105DKQ ROK family HP432_RS09645 ENOG4105F27 Major Facilitator HP432_RS09650 ENOG4105EYH Exonuclease HP432_RS09655 ENOG4107RH8 nuclease SbcCD subunit D HP432_RS09660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP432_RS09665 ENOG4105BZU Histidine kinase HP432_RS09670 ENOG4105CWM branched-chain amino acid transport system II carrier protein HP432_RS09675 ENOG4105C85 amino acid HP432_RS09680 ENOG4107R28 alpha amylase, catalytic region HP432_RS09685 ENOG4108ZYK Acyl carrier protein phosphodiesterase HP432_RS09700 ENOG4105VIE preprotein translocase, subunit YajC HP432_RS09705 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HP432_RS09710 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HP432_RS09715 ENOG4105N1F Hnh endonuclease HP432_RS09720 ENOG4105DRB nucleoside-specific channel-forming protein HP432_RS09725 ENOG4108KIC (LipO)protein HP432_RS09735 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HP432_RS09740 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HP432_RS09750 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HP432_RS09755 ENOG4108ZAI phosphatidylglycerophosphatase a HP432_RS09760 ENOG4105CPC Aldo Keto reductase HP432_RS09770 ENOG4105CTB Polyprenyl synthetase HP432_RS09780 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HP432_RS09785 ENOG4107S0N DJ-1 family HP432_RS09790 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HP432_RS09800 ENOG4107RDB Major Facilitator HP432_RS09810 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HP432_RS09815 ENOG4105CCU oxidase (Subunit III) HP432_RS09820 ENOG4105BZ9 Cytochrome C oxidase, subunit I HP432_RS09825 ENOG4105E2S oxidase) subunit II HP432_RS09830 ENOG4105EYM Major Facilitator superfamily HP432_RS09835 ENOG4105IEY (LipO)protein HP432_RS09840 ENOG4105M85 Bola protein HP432_RS09860 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HP432_RS09865 ENOG4105K70 DNA-binding protein HP432_RS09870 ENOG4105EIN peptidylprolyl cis-trans isomerase HP432_RS09875 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HP432_RS09885 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HP432_RS09890 ENOG4108NFA extracellular solute-binding protein HP432_RS09895 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HP432_RS09900 ENOG4108XM1 transcriptional regulator AsnC family HP432_RS09905 ENOG4105BZ1 (ABC) transporter HP432_RS09910 ENOG4105BZ1 (ABC) transporter HP432_RS09915 ENOG4108YZA Nitrogen regulatory protein pii HP432_RS09920 ENOG4105BZU Histidine kinase HP432_RS09925 ENOG4105C29 acyl-CoA thioesterase HP432_RS09930 ENOG4108MNP Glycoprotein polysaccharide metabolism HP432_RS09935 ENOG41080UX Methyltransferase HP432_RS09945 ENOG4105KCV RNA signal recognition particle 4.5S RNA HP432_RS09955 ENOG4105GSJ Inner membrane protein ylaC HP432_RS09960 ENOG4108UW5 maltose o-acetyltransferase HP432_RS09965 ENOG4105KF5 hemolysin expression-modulating protein HP432_RS09970 ENOG4108UKR Biofilm formation regulator YbaJ HP432_RS09975 ENOG4105BZS acriflavin resistance protein HP432_RS09980 ENOG4105C1P efflux transporter, rnd family, mfp subunit HP432_RS09985 ENOG4107XI7 Tetr family transcriptional regulator HP432_RS09990 ENOG4105EGS Mechanosensitive ion channel HP432_RS09995 ENOG4106428 Protein of unknown function (DUF2496) HP432_RS10000 ENOG4108URS primosomal replication protein n'' HP432_RS10005 ENOG4105WD1 Membrane HP432_RS10015 ENOG4107QMP dna polymerase iii subunits gamma and tau HP432_RS10050 ENOG4107RE1 Inosine-guanosine kinase HP432_RS10055 ENOG4105CKD glutathione-regulated potassium-efflux system protein HP432_RS10060 ENOG4105EU0 Major facilitator Superfamily HP432_RS10065 ENOG4105CGH 5'-nucleotidase HP432_RS10070 ENOG4108Z66 YbaK ebsC protein HP432_RS10075 ENOG4105MBR gumn family HP432_RS10080 ENOG41081XE plasmid maintenance system antidote protein, xre family HP432_RS10085 ENOG4105C59 p-type ATPase HP432_RS10090 ENOG4105CSV Glutaminase HP432_RS10095 ENOG4107RY6 amino acid HP432_RS10100 ENOG4108Z6Z Transcriptional regulator HP432_RS10105 ENOG4105G5H Membrane HP432_RS10110 ENOG4107QX8 SPFH domain, Band 7 family protein HP432_RS10115 ENOG41083J0 (ABC) transporter HP432_RS10120 ENOG4105C4B ABC transporter, permease HP432_RS10125 ENOG4107QR8 Thioredoxin HP432_RS10130 ENOG4105E1F short-chain dehydrogenase reductase HP432_RS10135 ENOG4108UJV acyl-CoA thioesterase i HP432_RS10140 ENOG4108I0Y (ABC) transporter HP432_RS10145 ENOG4105CV6 ABC transporter, permease HP432_RS10155 ENOG4107653 Transcriptional regulator HP432_RS10165 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HP432_RS10170 ENOG41060W2 glyoxylate carboligase HP432_RS10175 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HP432_RS10180 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HP432_RS10185 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HP432_RS10190 ENOG4105CD3 dihydroorotase HP432_RS10210 ENOG4105BZW Glycerate kinase HP432_RS10225 ENOG4107R1Q Membrane protein FdrA HP432_RS10230 ENOG4107REC cytoplasmic protein HP432_RS10235 ENOG4105G5A Protein of unknown function (DUF2877) HP432_RS10240 ENOG4105C5B carbamate kinase HP432_RS10245 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HP432_RS10250 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HP432_RS10260 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HP432_RS10270 ENOG4105S2T inner membrane protein YbcI HP432_RS10275 ENOG4105WQ3 Rna-binding protein HP432_RS10280 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HP432_RS10285 ENOG4108WDE Fimbrial protein HP432_RS10290 ENOG4108AF8 Chaperone HP432_RS10295 ENOG4105CW0 outer membrane usher protein HP432_RS10300 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HP432_RS10305 ENOG4108ZI2 Fimbrial protein HP432_RS10310 ENOG4108Q9V regulatoR HP432_RS10325 ENOG4105QUW HP432_RS10330 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HP432_RS10335 ENOG410802X bacteriophage n4 adsorption protein b HP432_RS10340 ENOG410600T transposase HP432_RS10355 ENOG4105CNA YD repeat protein HP432_RS10365 ENOG4105CS6 Rhs element vgr protein HP432_RS10370 ENOG4105GR3 Histidine kinase HP432_RS10375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP432_RS10380 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HP432_RS10385 ENOG410624V efflux system protein HP432_RS10390 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HP432_RS10395 ENOG4108IJF Heavy metal efflux pump, CzcA HP432_RS10400 ENOG4105C85 amino acid HP432_RS10405 ENOG4105CUY Mechanosensitive ion channel HP432_RS10410 ENOG4108RCM Nitroreductase HP432_RS10415 ENOG4105MSB protein, conserved in bacteria HP432_RS10420 ENOG4105WQ6 Membrane HP432_RS10425 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HP432_RS10435 ENOG4107635 Hok Gef family protein HP432_RS10440 ENOG4108SER Transposase HP432_RS10445 ENOG4108TSE Transferase HP432_RS10450 ENOG4107RNH Outer membrane receptor FepA HP432_RS10455 ENOG4105E93 esterase HP432_RS10460 ENOG41085A6 mbth domain-containing protein HP432_RS10465 ENOG4105C0W non-ribosomal peptide synthetase HP432_RS10470 ENOG4108QY5 Ferric enterobactin transport protein HP432_RS10475 ENOG4105E0A ABC, transporter HP432_RS10480 ENOG4105TVJ transport system, permease HP432_RS10485 ENOG4105DQ5 transport system permease protein HP432_RS10495 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HP432_RS10500 ENOG4105E4F Isochorismate synthase HP432_RS10505 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HP432_RS10510 ENOG4105WQI isochorismatase HP432_RS10515 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HP432_RS10520 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HP432_RS10525 ENOG4105D22 carbon starvation protein HP432_RS10530 ENOG4105VCD cytoplasmic protein HP432_RS10535 ENOG4107SCQ Iron-containing alcohol dehydrogenase HP432_RS10540 ENOG4105CHM Aminotransferase HP432_RS10545 ENOG4105GTN ParB Domain Protein Nuclease HP432_RS10550 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HP432_RS10555 ENOG4105DQS Transcriptional regulator HP432_RS10560 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HP432_RS10565 ENOG4105D3R alkyl hydroperoxide reductase HP432_RS10570 ENOG4108JU3 Alkyl hydroperoxide reductase HP432_RS10575 ENOG4108U51 Universal stress protein HP432_RS10580 ENOG4105E2A Dehydrogenase HP432_RS10585 ENOG4105NXH GreA GreB family elongation factor HP432_RS10590 ENOG4105KTS ribonuclease HP432_RS10595 ENOG4107QPK )-transporter HP432_RS10610 ENOG4105CHY citrate lyase, alpha HP432_RS10615 ENOG4105CI0 Citrate lyase HP432_RS10625 ENOG4105DUA (citrate (pro-3S)-lyase ligase HP432_RS10630 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HP432_RS10635 ENOG4106YYS transcriptional regulatory protein HP432_RS10640 ENOG4105CEE C4-dicarboxylate transporter HP432_RS10645 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HP432_RS10655 ENOG4107Z6W Protein CrcB homolog HP432_RS10665 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HP432_RS10675 ENOG41064T2 transcriptional regulator, lysR family HP432_RS10690 ENOG4105DZ1 carboxypeptidase HP432_RS10695 ENOG4105K6T rare lipoprotein A HP432_RS10700 ENOG4105CNI cell division protein FtsW HP432_RS10705 ENOG4105CJN penicillin-binding protein HP432_RS10715 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HP432_RS10720 ENOG4108TGR phosphatase HP432_RS10730 ENOG4105DJF DNA polymerase III, delta' subunit HP432_RS10735 ENOG4108U2H Rare lipoprotein B HP432_RS10740 ENOG4105C8T Leucyl-tRNA synthetase HP432_RS10745 ENOG4107PAI alpha helical protein HP432_RS10750 ENOG4105EUU Sel1 domain protein repeat-containing protein HP432_RS10755 ENOG41069CF Protein of unknown function (DUF1266) HP432_RS10760 ENOG4105QFC Hsc56 co-chaperone of HscC HP432_RS10765 ENOG4107JFD Sel1 repeat HP432_RS10770 ENOG41069CF Protein of unknown function (DUF1266) HP432_RS10775 ENOG4105QFC Hsc56 co-chaperone of HscC HP432_RS10780 ENOG4105F7F Chaperone HP432_RS10785 ENOG4105DU0 nucleoside hydrolase HP432_RS10790 ENOG4105CDA abc transporter atp-binding protein HP432_RS10795 ENOG4105DRP amino acid AbC transporter HP432_RS10800 ENOG4105EAD ABC transporter HP432_RS10805 ENOG4107RP9 extracellular solute-binding protein, family 3 HP432_RS10810 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HP432_RS10815 ENOG4108JU5 Magnesium and cobalt efflux protein HP432_RS10825 ENOG4105C9A Phoh family HP432_RS10835 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HP432_RS10875 ENOG4105CAQ asparagine synthetase HP432_RS10880 ENOG4105D4U had-superfamily hydrolase, subfamily iia HP432_RS10885 ENOG4105E2R ROK family HP432_RS10890 ENOG4105CE4 GlcNAc 6-P deacetylase HP432_RS10900 ENOG4105CI1 PTS System HP432_RS10915 ENOG4105GX6 (LipO)protein HP432_RS10920 ENOG41090R7 Ferric uptake HP432_RS10930 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HP432_RS10935 ENOG4105NNH LexA regulated protein HP432_RS10940 ENOG4105EV9 Alpha Beta Hydrolase HP432_RS10945 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HP432_RS10950 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HP432_RS10970 ENOG4105D5Q Arginine ornithine antiporter HP432_RS10975 ENOG4105CXN decarboxylase HP432_RS10985 ENOG4105EEX Two component transcriptional regulator (Winged helix family HP432_RS10990 ENOG4105C08 Histidine kinase HP432_RS11015 ENOG4105XIQ Protein of unknown function (DUF2517) HP432_RS11020 ENOG4105CNA YD repeat protein HP432_RS11025 ENOG41079JQ Membrane HP432_RS11030 ENOG4105CNA YD repeat protein HP432_RS11035 ENOG4106R09 HP432_RS11080 ENOG4107SEY Conserved Protein HP432_RS11085 ENOG4105CVP deoxyribo-dipyrimidine photolyase HP432_RS11090 ENOG4105DUX Transporter HP432_RS11095 ENOG4107QNR UPF0135 protein HP432_RS11100 ENOG4105P4J Allophanate hydrolase, subunit 1 HP432_RS11105 ENOG4107R7A Allophanate hydrolase subunit 2 HP432_RS11110 ENOG4105E7W lamb ycsf family protein HP432_RS11120 ENOG4108KK1 membrane protein AbrB duplication HP432_RS11140 ENOG4108TTM chaperone HP432_RS11145 ENOG4106PG1 outer membrane usher protein HP432_RS11150 ENOG4106UBK fimbrial-like adhesin protein HP432_RS11155 ENOG4105BZN citrate synthase HP432_RS11165 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HP432_RS11170 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HP432_RS11175 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HP432_RS11180 ENOG4105E33 succinate dehydrogenase HP432_RS11185 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HP432_RS11190 ENOG4105C7S Dehydrogenase HP432_RS11200 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HP432_RS11205 ENOG4105FDP GntR family transcriptional regulator HP432_RS11210 ENOG4105DM4 PTS System HP432_RS11215 ENOG4105C8I hydrolase, family 38 HP432_RS11220 ENOG4105C4M (Ubiquinol oxidase) subunit I HP432_RS11225 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HP432_RS11235 ENOG4105KJB cyd operon protein YbgE HP432_RS11240 ENOG4107YD3 Thioesterase HP432_RS11245 ENOG4105E02 MotA TolQ exbB proton channel HP432_RS11255 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HP432_RS11265 ENOG4105KCK Peptidoglycan-associated lipoprotein HP432_RS11270 ENOG4105UFD tol-pal system protein YbgF HP432_RS11310 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HP432_RS11315 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HP432_RS11320 ENOG4105PGM cation diffusion facilitator family transporter HP432_RS11325 ENOG4105JND homeobox protein HP432_RS11330 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HP432_RS11340 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HP432_RS11350 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HP432_RS11355 ENOG4105CMR udp-glucose 4-epimerase HP432_RS11360 ENOG4105DKW ABC transporter HP432_RS11365 ENOG4105F4R Transcriptional regulator mode HP432_RS11375 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HP432_RS11380 ENOG4105E0C molybdate abc transporter HP432_RS11385 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HP432_RS11390 ENOG4108K4B hydrolase HP432_RS11400 ENOG4105F04 LysR family Transcriptional regulator HP432_RS11405 ENOG4105C7F AcnD-accessory protein PrpF HP432_RS11410 ENOG4107QPK )-transporter HP432_RS11415 ENOG4107QM5 aconitate hydratase HP432_RS11420 ENOG4105NBR Pectinesterase HP432_RS11425 ENOG4108V1U phospholipid-binding protein HP432_RS11430 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HP432_RS11440 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HP432_RS11445 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HP432_RS11450 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HP432_RS11460 ENOG4105CHW UPF0052 protein HP432_RS11470 ENOG4108RIR Molybdenum cofactor biosynthesis protein HP432_RS11480 ENOG4105M00 molybdopterin converting factor, subunit 1 HP432_RS11485 ENOG4108ZAF Molybdopterin HP432_RS11490 ENOG4105HFZ Membrane HP432_RS11495 ENOG410733J conserved inner membrane protein HP432_RS11500 ENOG4107UXM Membrane HP432_RS11505 ENOG4105DZQ phospholipase D Transphosphatidylase HP432_RS11510 ENOG4105X23 Endonuclease Exonuclease phosphatase HP432_RS11515 ENOG4105I9U inner membrane protein ybhQ HP432_RS11520 ENOG4107QWP ABC-2 type transporter HP432_RS11525 ENOG4107QWP ABC-2 type transporter HP432_RS11530 ENOG4105CJ1 ABC, transporter HP432_RS11540 ENOG4107MVR Transcriptional regulator HP432_RS11545 ENOG4105C1J atp-dependent rna helicase HP432_RS11550 ENOG4108UV1 cellular component movement HP432_RS11555 ENOG4105DVT helicase HP432_RS11560 ENOG4108MTB glycosyl transferase family HP432_RS11565 ENOG4105DG4 malate L-lactate dehydrogenase HP432_RS11570 ENOG4105VR4 UPF0379 protein ybiJ HP432_RS11575 ENOG4105KSC Transcriptional regulator, TraR DksA family HP432_RS11585 ENOG4108IU3 tonb-dependent siderophore receptor HP432_RS11590 ENOG4105ZY9 UPF0379 protein ybiM HP432_RS11600 ENOG4105D8X mechanosensitive ion channel HP432_RS11605 ENOG4105CDA abc transporter atp-binding protein HP432_RS11610 ENOG4105E5Q amino acid AbC transporter HP432_RS11615 ENOG4107R0W ABC transporter HP432_RS11625 ENOG4107AQZ Membrane HP432_RS11635 ENOG4108T1M outer membrane protein x HP432_RS11640 ENOG4108I6E Sulfatase HP432_RS11650 ENOG4105KST dependent repressor HP432_RS11655 ENOG4105F4P )-transporter HP432_RS11660 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HP432_RS11665 ENOG4105C5H ABC transporter HP432_RS11670 ENOG41072TH Protein of unknown function (DUF1479) HP432_RS11675 ENOG4108HCJ Hydrolase HP432_RS11685 ENOG4105F1A Pyruvate formate-lyase HP432_RS11690 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP432_RS11695 ENOG4105D06 uba thif-type nad fad binding protein HP432_RS11700 ENOG4105CVM Molybdenum cofactor synthesis domain protein HP432_RS11705 ENOG4105D44 asparaginase HP432_RS11730 ENOG4105BZU Histidine kinase HP432_RS11750 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HP432_RS11755 ENOG4105D8V Glucose sorbosone dehydrogenase HP432_RS11760 ENOG4108TGY Glutathione S-transferase HP432_RS11765 ENOG4105DZ1 carboxypeptidase HP432_RS11770 ENOG4107FB0 transcriptional regulator DeoR family HP432_RS11775 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HP432_RS11780 ENOG4107QF7 multi-drug HP432_RS11790 ENOG4108HCJ Hydrolase HP432_RS11795 ENOG4106UW1 Major Facilitator superfamily HP432_RS11800 ENOG4108RFG Tetr family transcriptional regulator HP432_RS11805 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HP432_RS11820 ENOG4105MEH HP432_RS11845 ENOG4105KSC Transcriptional regulator, TraR DksA family HP432_RS11850 ENOG4105DFE Dna adenine methylase HP432_RS11855 ENOG4105VZ1 Replication Protein HP432_RS11875 ENOG4105ED4 portal protein HP432_RS11960 ENOG4105ZTC transcriptional activator, Ogr delta HP432_RS11970 ENOG4105GWF inner membrane protein YbjM HP432_RS11975 ENOG41090BQ Glutaredoxin HP432_RS11980 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HP432_RS11985 ENOG4108DBC nitroreductase HP432_RS11995 ENOG4108RMJ sensory transduction regulator HP432_RS12000 ENOG4107RUE extracellular solute-binding protein family 1 HP432_RS12005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HP432_RS12010 ENOG4105F38 ABC transporter, permease HP432_RS12015 ENOG4105D38 putrescine abc transporter HP432_RS12020 ENOG4105RBQ inner membrane protein ybjO HP432_RS12025 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HP432_RS12030 ENOG4106TNF Periplasmic binding protein HP432_RS12035 ENOG4105DMR ABC, transporter HP432_RS12040 ENOG4105GBT ABC transporter HP432_RS12045 ENOG4106PMH Extracellular solute-binding protein family 3 HP432_RS12050 ENOG4105E5Z arginine transporter ATP-binding subunit HP432_RS12055 ENOG41064MM (LipO)protein HP432_RS12065 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HP432_RS12070 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HP432_RS12075 ENOG4105CGD Nad-dependent epimerase dehydratase HP432_RS12080 ENOG4105C5W Aldolase HP432_RS12085 ENOG4105C7K acetolactate synthase HP432_RS12090 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HP432_RS12100 ENOG4105DWU Membrane HP432_RS12105 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HP432_RS12115 ENOG4105CPB ATP-dependent endonuclease of the OLD family HP432_RS12120 ENOG4108MJ5 VirK protein HP432_RS12125 ENOG4105DJY efflux transporter, rnd family, mfp subunit HP432_RS12130 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HP432_RS12135 ENOG4105VEQ Cold shock protein HP432_RS12145 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HP432_RS12155 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HP432_RS12165 ENOG4108JJ8 (ABC) transporter HP432_RS12170 ENOG4108JJ9 ABC, transporter HP432_RS12175 ENOG4105C3M thioredoxin reductase HP432_RS12185 ENOG4105CNU cell division protein FtsK HP432_RS12195 ENOG4105D1H recombination factor protein RarA HP432_RS12205 ENOG4107QY8 reductase HP432_RS12210 ENOG4105QAX Iron-sulfur HP432_RS12215 ENOG4107KGK dmso reductase anchor subunit HP432_RS12220 ENOG4105CHJ isochorismatase hydrolase HP432_RS12235 ENOG4105E5D amino acid HP432_RS12240 ENOG410642W LysR family Transcriptional regulator HP432_RS12245 ENOG4108X0B nad(p)h dehydrogenase (quinone) HP432_RS12250 ENOG4105F1A Pyruvate formate-lyase HP432_RS12255 ENOG4105C6N Formate acetyltransferase HP432_RS12260 ENOG4105TMB Formate nitrite transporter HP432_RS12265 ENOG4105DDY UPF0142 protein ycaO HP432_RS12270 ENOG4107VMU Membrane HP432_RS12275 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HP432_RS12285 ENOG4108K0D peptidase, M48 HP432_RS12295 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HP432_RS12305 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HP432_RS12310 ENOG4105BZ1 (ABC) transporter HP432_RS12315 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HP432_RS12320 ENOG4105T0Z Conserved Protein HP432_RS12335 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HP432_RS12340 ENOG4107S90 membrAne HP432_RS12345 ENOG4106371 Methyltransferase HP432_RS12355 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HP432_RS12360 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HP432_RS12365 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HP432_RS12370 ENOG4105EAQ (twin-arginine translocation) pathway signal HP432_RS12375 ENOG4105C5X domain protein HP432_RS12380 ENOG4105CGF Aromatic amino acid aminotransferase HP432_RS12385 ENOG4105FCK Membrane HP432_RS12395 ENOG4107RH7 Nicotinate phosphoribosyltransferase HP432_RS12400 ENOG4105CD8 aminopeptidase N HP432_RS12405 ENOG4105E2Y ABC, transporter HP432_RS12410 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HP432_RS12420 ENOG4105GVF (ABC) transporter HP432_RS12425 ENOG4108UZX fmn reductase HP432_RS12445 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HP432_RS12450 ENOG4105CW0 outer membrane usher protein HP432_RS12455 ENOG4108MDY Fimbrial HP432_RS12460 ENOG4105Q7J Fimbrial HP432_RS12465 ENOG4105MX3 Fimbrial HP432_RS12470 ENOG4106PH7 chaperone HP432_RS12480 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HP432_RS12485 ENOG4105QVC MOSC domain-containing protein HP432_RS12495 ENOG4105C5H ABC transporter HP432_RS12500 ENOG4105F1S paraquat-inducible protein a HP432_RS12505 ENOG4105DY2 Paraquat-inducible protein b HP432_RS12510 ENOG4108Q2G (LipO)protein HP432_RS12515 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HP432_RS12525 ENOG4105DAN ATP-dependent protease HP432_RS12535 ENOG4105UYK outer membrane protein a HP432_RS12545 ENOG4108RZ1 DNA transformation protein HP432_RS12550 ENOG4105EM2 membrane HP432_RS12555 ENOG410901E Membrane HP432_RS12560 ENOG41088T4 Helicase IV HP432_RS12575 ENOG4105K4P CoA-binding domain protein HP432_RS12590 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HP432_RS12595 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HP432_RS12600 ENOG4108MN8 Membrane HP432_RS12610 ENOG4105E3S small subunit HP432_RS12615 ENOG4105DPX Hydrogenase, large subunit HP432_RS12620 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HP432_RS12625 ENOG4108USZ hydrogenase HP432_RS12630 ENOG4108VXY Hydrogenase-1 operon protein HyaE HP432_RS12635 ENOG4105MVP hydrogenase-1 operon protein HyaF HP432_RS12640 ENOG4105C4M (Ubiquinol oxidase) subunit I HP432_RS12645 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HP432_RS12655 ENOG4105D6F Phosphatase HP432_RS12665 ENOG4107ZF2 Phosphatase HP432_RS12670 ENOG4105DAY polysaccharide export protein HP432_RS12675 ENOG4105E3R (LipO)protein HP432_RS12680 ENOG4108W78 Pfam:DUF1017 HP432_RS12685 ENOG4108Y9B (LipO)protein HP432_RS12700 ENOG41060EU Cold shock-like protein HP432_RS12705 ENOG4105VEQ Cold shock protein HP432_RS12720 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HP432_RS12725 ENOG4105HEE Binding Domain protein HP432_RS12730 ENOG4105BZU Histidine kinase HP432_RS12735 ENOG4108SV3 Tmao reductase system periplasmic protein tort HP432_RS12740 ENOG4106WF9 DNA-binding transcriptional regulator TorR HP432_RS12745 ENOG4105CUW cytochrome C-TYPE protein HP432_RS12750 ENOG4107QY8 reductase HP432_RS12775 ENOG4105D6F Phosphatase HP432_RS12780 ENOG4105XH3 HP432_RS12790 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HP432_RS12795 ENOG4105C2W permease HP432_RS12810 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HP432_RS12820 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HP432_RS12830 ENOG4108R86 Transcriptional regulator HP432_RS12835 ENOG4105C26 Dehydrogenase HP432_RS12845 ENOG4105CK7 Sodium proline symporter HP432_RS12855 ENOG410650H (LipO)protein HP432_RS12860 ENOG4105DBE peroxidase HP432_RS12865 ENOG4105D5M phosphate starvation-inducible protein HP432_RS12875 ENOG4105CND Glycosyl transferase, family 2 HP432_RS12880 ENOG4107BJW polysaccharide deacetylase HP432_RS12885 ENOG4108TUY outer membrane protein PgaA HP432_RS12890 ENOG4105BZU Histidine kinase HP432_RS12905 ENOG4108T85 Membrane HP432_RS12915 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HP432_RS12920 ENOG4107SSZ Phosphatase HP432_RS12925 ENOG4107XHZ cytoplasmic chaperone TorD family protein HP432_RS12930 ENOG4108UQ5 membrane protein YcdZ HP432_RS12935 ENOG4105P8Q Curli production assembly transport component CsgG HP432_RS12940 ENOG4108WYR Curli production assembly transport component, CsgF HP432_RS12945 ENOG4108XDW curli assembly protein CsgE HP432_RS12950 ENOG41086KC Transcriptional regulator HP432_RS12955 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HP432_RS12960 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HP432_RS12965 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HP432_RS12975 ENOG4108UVJ appr-1-p processing domain protein HP432_RS12980 ENOG4107RZC phospholipase d HP432_RS12985 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HP432_RS12990 ENOG4105DJ9 glucan biosynthesis protein HP432_RS12995 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HP432_RS13000 ENOG4105NAC (LipO)protein HP432_RS13005 ENOG4108W47 Acidic protein msyB HP432_RS13015 ENOG4105D1S lipid A biosynthesis HP432_RS13020 ENOG4105C72 UPF0176 protein HP432_RS13025 ENOG4108YYC ycei family HP432_RS13030 ENOG4105DS1 cytochrome b561 HP432_RS13035 ENOG4106974 biofilm formation HP432_RS13045 ENOG4105PVA Biofilm formation regulatory protein BssS HP432_RS13050 ENOG4105MEA DNA damage-inducible protein i HP432_RS13060 ENOG4105F3T (LipO)protein HP432_RS13065 ENOG4105E9S glutaredoxin 2 HP432_RS13075 ENOG4105D9U N-acetyltransferase HP432_RS13080 ENOG4108YXG UPF0502 protein HP432_RS13085 ENOG4105EP9 oxidoreductase HP432_RS13090 ENOG4105CJR Integral membrane protein (MviN HP432_RS13095 ENOG4105QVD Flagella synthesis protein FlgN HP432_RS13100 ENOG4105M9M anti-sigma28 factor FlgM HP432_RS13105 ENOG4105CKS Flagella basal body P-ring formation protein flgA HP432_RS13110 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HP432_RS13115 ENOG4108ZC9 flagellar basal-body rod protein flgc HP432_RS13120 ENOG4105W00 Flagellar hook capping protein HP432_RS13125 ENOG4105BZE flagellar hook protein, FlgE HP432_RS13130 ENOG4108KPB Flagellar basal-body rod protein FlgF HP432_RS13135 ENOG4105CGA flagellar basal-body rod protein FlgG HP432_RS13150 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HP432_RS13155 ENOG4105E1Q flagellar hook-associated protein HP432_RS13160 ENOG4105DTJ flagellar hook-associated protein HP432_RS13165 ENOG4107QQB Ribonuclease E HP432_RS13170 ENOG4105EI2 Pseudouridine synthase HP432_RS13175 ENOG4108UHJ MAF-like protein HP432_RS13180 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HP432_RS13200 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HP432_RS13205 ENOG4105CHR reductase HP432_RS13210 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HP432_RS13215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HP432_RS13220 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HP432_RS13225 ENOG4105HHA aminodeoxychorismate lyase HP432_RS13235 ENOG4107QRG dna polymerase iii HP432_RS13240 ENOG4105F8V Hydrolase, tatD family HP432_RS13245 ENOG4105CI1 PTS System HP432_RS13250 ENOG4105CNM Receptor HP432_RS13255 ENOG4105K59 histidine triad (HIT) protein HP432_RS13260 ENOG41090DQ Lipoprotein HP432_RS13265 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HP432_RS13270 ENOG4108RUM thiamine kinase HP432_RS13275 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HP432_RS13285 ENOG4105CEP NADH dehydrogenase HP432_RS13290 ENOG4107MBR 17 kDa surface antigen HP432_RS13295 ENOG4108IND Tetr family transcriptional regulator HP432_RS13300 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HP432_RS13305 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HP432_RS13310 ENOG4108JA2 transcriptioN-repair coupling factor HP432_RS13315 ENOG4105IQC Inner membrane protein YcfT HP432_RS13320 ENOG4105D60 lipoprotein releasing system transmembrane protein HP432_RS13325 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HP432_RS13330 ENOG4105D60 lipoprotein releasing system transmembrane protein HP432_RS13340 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HP432_RS13355 ENOG4107RUE extracellular solute-binding protein family 1 HP432_RS13360 ENOG4105D38 putrescine abc transporter HP432_RS13380 ENOG4105EZE Cupin 4 family protein HP432_RS13385 ENOG4105IFJ Histidine kinase HP432_RS13390 ENOG4105XJC Two component transcriptional regulator (Winged helix family HP432_RS13395 ENOG4107QTF adenylosuccinate lyase HP432_RS13415 ENOG4108R99 pseudouridine synthase HP432_RS13420 ENOG4108HMX isocitrate dehydrogenase (NADP) HP432_RS13425 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HP432_RS13435 ENOG41064WM Uncharacterized protein YcgX HP432_RS13440 ENOG4108XDN Transcriptional regulator HP432_RS13445 ENOG4105BZU Histidine kinase HP432_RS13450 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HP432_RS13455 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HP432_RS13465 ENOG410738I uncharacterized protein ymgC HP432_RS13505 ENOG410658X HP432_RS13540 ENOG4107QMS site-determining protein HP432_RS13550 ENOG4105S66 prophage protein HP432_RS13555 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HP432_RS13565 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HP432_RS13585 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HP432_RS13590 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HP432_RS13605 ENOG4105ED1 spovr family HP432_RS13615 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HP432_RS13625 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HP432_RS13630 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HP432_RS13635 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HP432_RS13640 ENOG4105Y3U Transglycosylase-associated protein HP432_RS13665 ENOG4105VDH Dihydroxyacetone kinase HP432_RS13670 ENOG4108UTZ Dihydroxyacetone kinase HP432_RS13675 ENOG4105CMT Dihydroxyacetone kinase HP432_RS13680 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HP432_RS13685 ENOG4105I1J Autotransporter HP432_RS13690 ENOG4105C3G gtp-binding protein HP432_RS13700 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HP432_RS13705 ENOG4105CHH sulfate transporter HP432_RS13710 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HP432_RS13735 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HP432_RS13740 ENOG4108YY7 Invasion gene expression up-regulator SirB HP432_RS13745 ENOG41063JG Transcriptional regulator HP432_RS13770 ENOG4105EWV Sodium calcium exchanger membrane region HP432_RS13775 ENOG4105WS7 Cation transport regulator HP432_RS13780 ENOG4108NH8 Cation transport protein HP432_RS13785 ENOG41090EX DsrE family HP432_RS13790 ENOG4105ID0 Putative invasin HP432_RS13795 ENOG4105WH1 Two component transcriptional regulator luxr family HP432_RS13800 ENOG4105BZU Histidine kinase HP432_RS13805 ENOG4105DQQ Major facilitator superfamily MFS_1 HP432_RS13810 ENOG4105CRU nitrate reductase, alpha subunit HP432_RS13815 ENOG4108IUE nitrate reductase beta subunit HP432_RS13820 ENOG4105R3A Nitrate reductase HP432_RS13825 ENOG41076YT nitrate reductase, gamma subunit HP432_RS13855 ENOG4105CIY formyltetrahydrofolate deformylase HP432_RS13860 ENOG4105K5B UPF0225 protein HP432_RS13865 ENOG4105D78 K07001 NTE family protein HP432_RS13870 ENOG4105I93 response regulator HP432_RS13875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HP432_RS13880 ENOG4108SAU DNA-binding protein H-ns HP432_RS13885 ENOG4107104 thymidine kinase HP432_RS13895 ENOG4105C0A alcohol dehydrogenase HP432_RS13900 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HP432_RS13910 ENOG4108J59 Extracellular solute-binding protein, family 5 HP432_RS13915 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP432_RS13920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP432_RS13925 ENOG4105C3U ABC transporter HP432_RS13930 ENOG4108JQ7 (ABC) transporter HP432_RS13950 ENOG4107SVH Potassium channel protein HP432_RS13955 ENOG4105K9H YciI-like protein HP432_RS13960 ENOG410822N TonB family HP432_RS13965 ENOG4105NAU thioesterase Superfamily protein HP432_RS13985 ENOG4105EIF outer membrane protein W HP432_RS13990 ENOG4108N8X transition metal ion binding HP432_RS13995 ENOG4108Z9Z response to DNA damage stimulus HP432_RS14015 ENOG4105DK0 Indole-3-glycerol phosphate synthase HP432_RS14020 ENOG4108EFP Anthranilate synthase component II HP432_RS14025 ENOG4105CRQ synthase (Component I) HP432_RS14035 ENOG4105DB7 PHP domain protein HP432_RS14040 ENOG4107RTD sua5 ycio yrdc ywlc family protein HP432_RS14045 ENOG4105EG3 transmembrane signal peptide protein HP432_RS14050 ENOG4105FE9 pseudouridine synthase HP432_RS14055 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HP432_RS14060 ENOG4105UBK short-chain dehydrogenase reductase HP432_RS14065 ENOG4105ERU peptidase HP432_RS14070 ENOG4105RKX Protein of unknown function (DUF2498) HP432_RS14075 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HP432_RS14080 ENOG4107R11 Transcriptional regulator HP432_RS14100 ENOG4107QM5 aconitate hydratase HP432_RS14110 ENOG4105EYK Phosphatidylglycerophosphatase B HP432_RS14115 ENOG4105Q4A inner membrane protein yciS HP432_RS14120 ENOG4105CFV Tetratricopeptide repeat protein HP432_RS14130 ENOG4108ZJT translation initiation factor, Sui1 HP432_RS14140 ENOG4105N2W Transcriptional regulator HP432_RS14145 ENOG410643D UPF0509 protein HP432_RS14150 ENOG4105BZU Histidine kinase HP432_RS14165 ENOG4105Q4T oxidoreductase HP432_RS14170 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HP432_RS14175 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HP432_RS14180 ENOG4108JQ2 peptide transport system atp-binding protein HP432_RS14185 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HP432_RS14190 ENOG4108EU3 peptide transport system, permease HP432_RS14195 ENOG4108I5W peptide transport system, permease protein HP432_RS14200 ENOG4108HIY periplasmic HP432_RS14205 ENOG4105N0E Protein of unknown function (DUF2543) HP432_RS14210 ENOG4105CUB amino acid HP432_RS14220 ENOG4105CFQ glutamine synthetase HP432_RS14225 ENOG4108Z86 Glutamine amidotransferase HP432_RS14230 ENOG4107VRI Transcriptional regulator HP432_RS14235 ENOG4105C26 Dehydrogenase HP432_RS14240 ENOG4105CJP fad dependent oxidoreductase HP432_RS14245 ENOG4108JPW Aminotransferase HP432_RS14250 ENOG4105E51 psp operon transcriptional activator HP432_RS14255 ENOG41087YS Phage shock protein A HP432_RS14260 ENOG4105YYT phage shock protein B HP432_RS14265 ENOG4105FM1 phage shock protein C HP432_RS14270 ENOG4105NNG Peripheral inner membrane phage-shock protein HP432_RS14275 ENOG4105K8Z Phage shock protein HP432_RS14280 ENOG4107QW3 Sucrose phosphorylase HP432_RS14295 ENOG4105WEM extracellular solute-binding protein HP432_RS14300 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HP432_RS14305 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HP432_RS14310 ENOG4107RRD Dehydrogenase HP432_RS14315 ENOG4107TYA transient receptor potential locus HP432_RS14320 ENOG4105CK5 oxidoreductase HP432_RS14325 ENOG4105C71 hydrolase family 65, central catalytic HP432_RS14330 ENOG4107URF beta-phospho-glucomutase HP432_RS14335 ENOG4108IJ9 (ABC) transporter HP432_RS14340 ENOG4107EFV Outer membrane protein G HP432_RS14345 ENOG4105FKQ transcriptional regulator HP432_RS14350 ENOG4105CM6 amino acid regulated cytosolic protein HP432_RS14360 ENOG4108JU8 Transcriptional regulator HP432_RS14365 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HP432_RS14370 ENOG4107S8C mandelate racemase muconate lactonizing HP432_RS14375 ENOG4105KXI murein peptide amidase A HP432_RS14390 ENOG4105ENX hydrolase HP432_RS14410 ENOG4107QSI ABC, transporter HP432_RS14415 ENOG4105D64 Mechanosensitive ion channel HP432_RS14420 ENOG4105S5I Membrane HP432_RS14425 ENOG4105Q9Y Universal stress protein HP432_RS14430 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HP432_RS14435 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HP432_RS14440 ENOG4105CFC Transporter HP432_RS14445 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HP432_RS14450 ENOG4105CH2 amidohydrolase HP432_RS14455 ENOG4106KR7 LysR family Transcriptional regulator HP432_RS14460 ENOG4108DG9 Smr protein MutS2 HP432_RS14465 ENOG4105BZU Histidine kinase HP432_RS14475 ENOG4105C1J atp-dependent rna helicase HP432_RS14485 ENOG4107R08 Integrase HP432_RS14490 ENOG4107160 Rac prophage HP432_RS14495 ENOG41070YT Rac prophage HP432_RS14500 ENOG4106YAH restriction alleviation and modification enhancement HP432_RS14505 ENOG4108PNI recT protein HP432_RS14510 ENOG41076J9 exonuclease VIII HP432_RS14520 ENOG4105JBR DNA replication protein HP432_RS14560 ENOG4108MXB Protein of unknown function (DUF968) HP432_RS14565 ENOG4105KSK (crossover) junction endodeoxyribonuclease HP432_RS14570 ENOG4105HGD Antitermination protein HP432_RS14595 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HP432_RS14620 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HP432_RS14625 ENOG4108ES9 ParB domain protein nuclease HP432_RS14645 ENOG4105UZW Tail fiber assembly protein HP432_RS14650 ENOG4105MN3 Resolvase HP432_RS14655 ENOG4105W3V DNA-binding, transcriptional regulator HP432_RS14665 ENOG4108RW8 Universal stress protein F HP432_RS14670 ENOG4105FCK Membrane HP432_RS14675 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HP432_RS14680 ENOG4105IKK cytoplasmic protein HP432_RS14685 ENOG41090X5 Heat shock protein hslJ HP432_RS14690 ENOG4105C5I Dehydrogenase HP432_RS14695 ENOG4107H52 Dicarboxylate transport HP432_RS14700 ENOG410689M (LipO)protein HP432_RS14705 ENOG4105WXT Conserved Protein HP432_RS14710 ENOG4108WFR AraC Family Transcriptional Regulator HP432_RS14715 ENOG4105C26 Dehydrogenase HP432_RS14720 ENOG4105F11 amine oxidase HP432_RS14725 ENOG4105DXM phenylacetic acid degradation protein HP432_RS14730 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HP432_RS14735 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HP432_RS14740 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HP432_RS14745 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HP432_RS14750 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HP432_RS14755 ENOG4105E39 Enoyl-CoA hydratase HP432_RS14760 ENOG4108UKI Enoyl-CoA hydratase HP432_RS14765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HP432_RS14770 ENOG4108ZJI phenylacetic acid degradation protein HP432_RS14775 ENOG4105CHU acetyl-coa acetyltransferase HP432_RS14780 ENOG4105DZS Phenylacetate-CoA ligase HP432_RS14785 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HP432_RS14790 ENOG4108Z0R Transferase HP432_RS14810 ENOG4107EF2 surface-exposed virulence protein HP432_RS14815 ENOG4107S5I aldo keto reductase HP432_RS14825 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HP432_RS14845 ENOG4105E8V Alpha Beta Hydrolase Fold protein HP432_RS14850 ENOG41077RS Phosphatase HP432_RS14860 ENOG4105CQ7 ATP-dependent helicase HP432_RS14865 ENOG4107DB1 DUF218 domain HP432_RS14870 ENOG4105C26 Dehydrogenase HP432_RS14875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HP432_RS14880 ENOG4105CPW cytochrome b561 HP432_RS14885 ENOG4105UPP uncharacterized protein ydcA HP432_RS14890 ENOG4107NK6 Hok/gef family HP432_RS14895 ENOG4105C8Q Methyl-accepting chemotaxis HP432_RS14900 ENOG4105DDW LysR family Transcriptional regulator HP432_RS14905 ENOG4105E32 cytoplasmic protein HP432_RS14915 ENOG4105Z2P Protein of unknown function (DUF465) HP432_RS14920 ENOG4108Z9I -acetyltransferase HP432_RS14925 ENOG4107WE3 acetyltransferase YdcK HP432_RS14930 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HP432_RS14935 ENOG41088CC tellurite resistance protein tehB HP432_RS14940 ENOG4108KKZ (LipO)protein HP432_RS14950 ENOG4105D7V transposase HP432_RS14955 ENOG4105DKK Benzoate HP432_RS14960 ENOG4108JCI Transcriptional regulator HP432_RS14965 ENOG4105CFP Peptidase U32 HP432_RS14970 ENOG4105RR0 Protein of unknown function (DUF2554) HP432_RS14980 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HP432_RS14985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HP432_RS14990 ENOG4107TYH extracellular solute-binding protein family 1 HP432_RS14995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HP432_RS15000 ENOG4105D81 ABC transporter, permease HP432_RS15005 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HP432_RS15020 ENOG410654E Membrane HP432_RS15025 ENOG4105R71 cytoplasmic protein HP432_RS15030 ENOG4108T9Y Inner membrane protein ydcZ HP432_RS15035 ENOG4108Z7F N-acetyltransferase HP432_RS15040 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HP432_RS15045 ENOG4108WYP Transcriptional regulator HP432_RS15050 ENOG4105CHB tonB-dependent Receptor HP432_RS15055 ENOG4108NS2 receptor HP432_RS15060 ENOG4105C85 amino acid HP432_RS15070 ENOG4108MXB Protein of unknown function (DUF968) HP432_RS15075 ENOG4105HRS Antitermination protein HP432_RS15090 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HP432_RS15095 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HP432_RS15110 ENOG4108YV9 Protein of unknown function (DUF2514) HP432_RS15115 ENOG4105VEQ Cold shock protein HP432_RS15130 ENOG4106IAW HP432_RS15135 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HP432_RS15140 ENOG41064WM Uncharacterized protein YcgX HP432_RS15145 ENOG4106YSC HP432_RS15150 ENOG4105FKG DNA packaging protein HP432_RS15165 ENOG4107DE1 head-to-tail joining protein HP432_RS15185 ENOG4105IM0 capsid protein HP432_RS15200 ENOG410685N tail fiber protein HP432_RS15205 ENOG4105UZW Tail fiber assembly protein HP432_RS15210 ENOG4105MN3 Resolvase HP432_RS15215 ENOG4105W3V DNA-binding, transcriptional regulator HP432_RS15230 ENOG4105DEI Mannitol dehydrogenase HP432_RS15235 ENOG41061EV selenium-binding protein YdfZ HP432_RS15240 ENOG4107XBN GntR Family Transcriptional Regulator HP432_RS15245 ENOG4105EMU Dehydrogenase HP432_RS15250 ENOG4105DGW oligopeptidase A HP432_RS15255 ENOG4108WTK competence damage-inducible protein HP432_RS15260 ENOG4108YDI single-species biofilm formation on inanimate substrate HP432_RS15265 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HP432_RS15275 ENOG4105E5W Transporter HP432_RS15280 ENOG4108594 Permease of the drug metabolite transporter HP432_RS15285 ENOG4105FDP GntR family transcriptional regulator HP432_RS15295 ENOG4105CK1 PTS System HP432_RS15300 ENOG4105VCP PTS System HP432_RS15320 ENOG4105CS2 ec 3.2.1.21 HP432_RS15325 ENOG4106DNR multiple antibiotic resistance protein HP432_RS15330 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HP432_RS15335 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HP432_RS15355 ENOG4105EGI Transcriptional regulator HP432_RS15360 ENOG4105C26 Dehydrogenase HP432_RS15365 ENOG4105CSV Glutaminase HP432_RS15370 ENOG4105M0C cytoplasmic protein HP432_RS15375 ENOG4105BZU Histidine kinase HP432_RS15385 ENOG4105FFC UPF0187 protein HP432_RS15390 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HP432_RS15395 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HP432_RS15405 ENOG4105D4B ABC, transporter HP432_RS15420 ENOG4105C2J ABC transporter HP432_RS15455 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HP432_RS15460 ENOG4105CAF HipA N-terminal domain protein HP432_RS15485 ENOG4106PIH fimbrial-like protein ydeQ HP432_RS15490 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HP432_RS15505 ENOG4105ENH Sulfatase HP432_RS15510 ENOG4105C4X radical SAM domain protein HP432_RS15520 ENOG4105CQ0 ABC transporter HP432_RS15525 ENOG4105PE1 Receptor HP432_RS15530 ENOG4107RAN Peptidase, M16 HP432_RS15535 ENOG4105CVK Glutamate decarboxylase HP432_RS15540 ENOG4105E5D amino acid HP432_RS15545 ENOG4105F32 YngK protein HP432_RS15550 ENOG4105BZU Histidine kinase HP432_RS15555 ENOG4105BZU Histidine kinase HP432_RS15560 ENOG4108UQS dipeptidase HP432_RS15565 ENOG4105DEF Extracellular solute-binding protein, family 5 HP432_RS15570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP432_RS15575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP432_RS15580 ENOG4105C3U ABC transporter HP432_RS15590 ENOG4108Z9K Osmotically inducible protein HP432_RS15595 ENOG4105TPS biofilm-dependent modulation protein HP432_RS15600 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HP432_RS15605 ENOG4107R1I NAD-dependent malic enzyme HP432_RS15610 ENOG4105DQ4 alcohol dehydrogenase HP432_RS15615 ENOG41084S7 Plasmid maintenance system antidote protein HP432_RS15620 ENOG4108MG3 formate dehydrogenase HP432_RS15625 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP432_RS15635 ENOG4105RPH Inner membrane protein YddG HP432_RS15660 ENOG4107QND Nitrite extrusion protein HP432_RS15665 ENOG4105CRU nitrate reductase, alpha subunit HP432_RS15670 ENOG4108IUE nitrate reductase beta subunit HP432_RS15675 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HP432_RS15680 ENOG4105D0D Nitrate reductase 2, gamma subunit HP432_RS15685 ENOG4105JAB phenazine biosynthesis protein, phzf family HP432_RS15690 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HP432_RS15695 ENOG4108MEJ flavin reductase domain protein HP432_RS15700 ENOG4105KZK Tautomerase pptA HP432_RS15705 ENOG410600T transposase HP432_RS15740 ENOG4108N27 Glutathione S-transferase HP432_RS15760 ENOG4105K4U addiction module toxin, RelE StbE family HP432_RS15800 ENOG4108MK9 spermidine N(1)-acetyltransferase HP432_RS15805 ENOG4105D69 UPF0257 lipoprotein ynfC HP432_RS15810 ENOG4105KBG Protein of unknown function (DUF1161) HP432_RS15815 ENOG4107QY8 reductase HP432_RS15820 ENOG4105C3J Cysteine desulfurase HP432_RS15825 ENOG4105QAX Iron-sulfur HP432_RS15830 ENOG4107KGK dmso reductase anchor subunit HP432_RS15835 ENOG4108NEM leader-binding protein dmsD HP432_RS15845 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HP432_RS15850 ENOG4105DAG ROK family HP432_RS15855 ENOG4106NZI LysR family Transcriptional regulator HP432_RS15860 ENOG4105D94 Major Facilitator Superfamily HP432_RS15875 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HP432_RS15890 ENOG4105DSF transport protein HP432_RS15895 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HP432_RS15900 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HP432_RS15905 ENOG4105C5D exported protein HP432_RS15910 ENOG4105D5Q Arginine ornithine antiporter HP432_RS15920 ENOG4105RA2 Membrane HP432_RS15925 ENOG4107EXC regulatoR HP432_RS15930 ENOG4105JJR Histidine kinase HP432_RS15935 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HP432_RS15940 ENOG4105C9Q fumarate hydratase class II HP432_RS15945 ENOG4107GFK fumarate HP432_RS15950 ENOG4105EIP mannose-6-phosphate isomerase HP432_RS15955 ENOG4106J39 exported protein HP432_RS15960 ENOG4108QNI outer membrane porin protein HP432_RS15965 ENOG4105CT4 transporter HP432_RS15970 ENOG4105CNT hydrolase family 2 HP432_RS15975 ENOG4105XEA Tetr family transcriptional regulator HP432_RS15980 ENOG4107ZQV short-chain dehydrogenase reductase HP432_RS15985 ENOG4107P2S Transcriptional regulator HP432_RS15990 ENOG4105CI1 PTS System HP432_RS15995 ENOG4105C87 Aminotransferase class I and II HP432_RS16005 ENOG4105D9R oxidoreductase HP432_RS16010 ENOG4106C6R beta-lactam resistance protein HP432_RS16015 ENOG4105QZ5 OriC-binding nucleoid-associated protein HP432_RS16020 ENOG4105M9B inner membrane protein ydgK HP432_RS16045 ENOG4108UQQ Electron transport complex HP432_RS16055 ENOG4105CSM endonuclease III HP432_RS16060 ENOG4105DUX Transporter HP432_RS16065 ENOG4108K3A Glutathione S-transferase HP432_RS16070 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HP432_RS16085 ENOG410642K Lysozyme inhibitor HP432_RS16095 ENOG4108XTF Outer Membrane Lipoprotein HP432_RS16110 ENOG4105Y49 secretion protein, HlyD family HP432_RS16115 ENOG4105DSW Fusaric acid resistance protein HP432_RS16120 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HP432_RS16125 ENOG4107RGM aldo keto reductase HP432_RS16130 ENOG4105XZD Fe-S protein HP432_RS16135 ENOG4108WUH Transcriptional regulator, TetR family HP432_RS16140 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HP432_RS16145 ENOG4108UYE Lactoylglutathione lyase HP432_RS16155 ENOG4107QRT dEAD DEAH box helicase HP432_RS16160 ENOG4105M2J Glutaredoxin HP432_RS16170 ENOG4105K4H Nlp p60 protein HP432_RS16175 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HP432_RS16180 ENOG4105F27 Major Facilitator HP432_RS16195 ENOG4105F52 Transcriptional regulator HP432_RS16200 ENOG4105CZQ inner membrane transport protein YdhC HP432_RS16205 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HP432_RS16210 ENOG4108R6K riboflavin synthase, subunit alpha HP432_RS16235 ENOG4105N0V mono-oxygenase ydhR HP432_RS16240 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HP432_RS16245 ENOG4108Y7C Conserved Protein HP432_RS16250 ENOG4108NWD Cytochrome HP432_RS16255 ENOG4108393 oxidoreductase Fe-S subunit HP432_RS16260 ENOG4105JVW HP432_RS16280 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HP432_RS16285 ENOG4105RFR Protein of unknown function (DUF2767) HP432_RS16290 ENOG4105CA9 Pyruvate kinase HP432_RS16295 ENOG4105KMX major outer membrane lipoprotein HP432_RS16300 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HP432_RS16315 ENOG4105JRK feS assembly protein SufD HP432_RS16320 ENOG4105C3K feS assembly ATPase SufC HP432_RS16325 ENOG4105DIW FeS assembly protein SUFB HP432_RS16330 ENOG4108Z4V iron-sulfur cluster assembly HP432_RS16335 ENOG410671Z uncharacterized protein ydiH HP432_RS16340 ENOG4105KA0 thioesterase Superfamily protein HP432_RS16345 ENOG4105CQB FAD linked oxidase domain protein HP432_RS16350 ENOG4105IPI Membrane HP432_RS16360 ENOG4105SUA Ydil protein HP432_RS16365 ENOG4105EMV Major Facilitator HP432_RS16370 ENOG4105EMV Major Facilitator HP432_RS16390 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HP432_RS16395 ENOG4105C1G acyl-Coa dehydrogenase HP432_RS16400 ENOG4105W4W Transcriptional regulator HP432_RS16405 ENOG4105CV7 Electron transfer flavoprotein HP432_RS16410 ENOG4105C10 Electron transfer flavoprotein HP432_RS16415 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HP432_RS16420 ENOG41090P5 ferredoxin-like protein HP432_RS16425 ENOG4105CEY Amp-dependent synthetase and ligase HP432_RS16430 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HP432_RS16440 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HP432_RS16455 ENOG4105CNG UPF0061 protein HP432_RS16460 ENOG4108TC0 Diguanylate phosphodiesterase HP432_RS16465 ENOG4108QBX (LipO)protein HP432_RS16475 ENOG4108V06 Glutathione peroxidase HP432_RS16490 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HP432_RS16510 ENOG41082NX 50s ribosomal protein l35 HP432_RS16515 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HP432_RS16535 ENOG4108NE3 Salt-induced outer membrane protein HP432_RS16540 ENOG4105DE4 1-phosphofructokinase HP432_RS16545 ENOG4105P10 Uncharacterized protein ydiZ HP432_RS16555 ENOG4107PN8 YfeABCD locus regulator HP432_RS16560 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HP432_RS16565 ENOG4107K5X Membrane-bound metal-dependent hydrolase HP432_RS16570 ENOG4108ETY sodium dicarboxylate symporter HP432_RS16585 ENOG4105CH6 catalase HP432_RS16595 ENOG4105F8D glycoside hydrolase family 4 HP432_RS16600 ENOG4105EZV Transcriptional regulator HP432_RS16605 ENOG4105VCP PTS System HP432_RS16610 ENOG4105CK1 PTS System HP432_RS16615 ENOG4105VZJ PTS System HP432_RS16620 ENOG4105KKI DNA-binding transcriptional activator OsmE HP432_RS16625 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HP432_RS16630 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HP432_RS16640 ENOG4108SPG Periplasmic Protein HP432_RS16645 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HP432_RS16650 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HP432_RS16655 ENOG4105C26 Dehydrogenase HP432_RS16670 ENOG4105CGK Exodeoxyribonuclease III HP432_RS16675 ENOG4108RSN SNARE associated Golgi HP432_RS16680 ENOG4108KCW iron-sulfur cluster binding HP432_RS16685 ENOG4108N5C SNARE associated Golgi protein-related protein HP432_RS16690 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HP432_RS16695 ENOG4105VNH ABC transporter solute-binding protein HP432_RS16700 ENOG4105CXZ ABC transporter, permease HP432_RS16705 ENOG4108VGW abc transporter atp-binding protein HP432_RS16710 ENOG4107RM6 sulfurtransferase HP432_RS16715 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HP432_RS16720 ENOG4105M6F mutator MutT protein HP432_RS16725 ENOG4105MTM Protein of unknown function (DUF1496) HP432_RS16730 ENOG4105D82 Glutamate dehydrogenase HP432_RS16735 ENOG41065FB inner membrane protein ynji HP432_RS16740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HP432_RS16750 ENOG41069NU Nitroreductase HP432_RS16755 ENOG4105D07 Signal peptide peptidase, SppA HP432_RS16760 ENOG4105HDK L-asparaginase HP432_RS16765 ENOG4108RWI nicotinamidase HP432_RS16770 ENOG4108KUU Inner membrane metabolite transport protein ydjE HP432_RS16775 ENOG4105E98 transcriptional regulator DeoR family HP432_RS16780 ENOG4105CPC Aldo Keto reductase HP432_RS16800 ENOG4105D2N Aldolase HP432_RS16805 ENOG4105CPQ Dehydrogenase HP432_RS16830 ENOG4105VUT cytoplasmic protein HP432_RS16840 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HP432_RS16845 ENOG4105DSB aldose 1-epimerase HP432_RS16850 ENOG4105CV8 reductase HP432_RS16855 ENOG4105GNX MltA-interacting MipA family protein HP432_RS16860 ENOG4105CYN Serine protein kinase HP432_RS16865 ENOG4106AKX UPF0229 protein HP432_RS16870 ENOG4106KTS Inner membrane protein yeaI HP432_RS16875 ENOG4108KHP Diguanylate cyclase HP432_RS16880 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HP432_RS16895 ENOG4105R1U AraC Family Transcriptional Regulator HP432_RS16900 ENOG4105DJ2 Major Facilitator Superfamily HP432_RS16905 ENOG4105K78 MarR family Transcriptional regulator HP432_RS16910 ENOG4105UCG Domain of unknown function (DUF333) HP432_RS16915 ENOG410620I Diguanylate cyclase HP432_RS16920 ENOG4106G4W HP432_RS16930 ENOG4105Y3U Transglycosylase-associated protein HP432_RS16935 ENOG4105YP6 Domain of unknown function (DUF1869) HP432_RS16940 ENOG4108YS1 cytoplasmic protein HP432_RS16950 ENOG4105F9F transposase HP432_RS16955 ENOG4105EJC lysr family transcriptional regulator HP432_RS16960 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HP432_RS16965 ENOG4105C94 Transporter HP432_RS16970 ENOG4105DVW rieske (2Fe-2S) HP432_RS16975 ENOG4105E3J oxidoreductase HP432_RS16980 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HP432_RS16985 ENOG4105CEY Amp-dependent synthetase and ligase HP432_RS16990 ENOG4105Y4Z Outer Membrane Lipoprotein HP432_RS16995 ENOG41072GX Peptidase M22 Glycoprotease HP432_RS17000 ENOG4105DVT helicase HP432_RS17005 ENOG4105M4H endoribonuclease L-psp HP432_RS17010 ENOG4105V2F Uncharacterized protein yoac HP432_RS17020 ENOG4105CRQ synthase (Component I) HP432_RS17030 ENOG4105EJQ L-serine dehydratase HP432_RS17040 ENOG4105EE5 Membrane protein terC HP432_RS17045 ENOG4105DAS pts system HP432_RS17050 ENOG4105ETZ PTS System HP432_RS17055 ENOG4105F3R pts system mannose fructose sorbose family iid HP432_RS17070 ENOG4105DHI Methyltransferase HP432_RS17085 ENOG4105Q3Y exported protein HP432_RS17095 ENOG4105TIK HP432_RS17100 ENOG4105J4Q Transcriptional regulator HP432_RS17105 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP432_RS17115 ENOG4105CN1 protease HP432_RS17125 ENOG4108ZGC gaf domain protein HP432_RS17130 ENOG4105H2K paraquat-inducible protein a HP432_RS17135 ENOG4105DY2 Paraquat-inducible protein b HP432_RS17145 ENOG4105WT8 Protein of unknown function (DUF1480) HP432_RS17150 ENOG4105UVW uncharacterized protein yebW HP432_RS17155 ENOG4108R1E Serine threonine protein phosphatase 1 HP432_RS17160 ENOG4105NKT exported protein HP432_RS17165 ENOG4108PNC copper resistance HP432_RS17170 ENOG4105FXM Copper resistance protein HP432_RS17175 ENOG4105MPK DNA polymerase III subunit theta HP432_RS17180 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HP432_RS17185 ENOG4105UMD exodeoxyribonuclease X HP432_RS17190 ENOG4105CUG Oligopeptidase b HP432_RS17195 ENOG4108Q2J Inner membrane protein YebE HP432_RS17205 ENOG4105X2V dna damage-inducible protein HP432_RS17215 ENOG4108UHU Aldolase HP432_RS17220 ENOG4105C01 Dihydroxy-acid dehydratase HP432_RS17225 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HP432_RS17230 ENOG4106KNT transcriptional regulator HP432_RS17235 ENOG4105CA9 Pyruvate kinase HP432_RS17240 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HP432_RS17245 ENOG4105DR5 peptidase HP432_RS17250 ENOG4105NXV High-affinity zinc uptake system protein HP432_RS17260 ENOG4105FAV ABC, transporter HP432_RS17290 ENOG4105CDY transcriptional regulatory protein HP432_RS17295 ENOG4108TIT dATP pyrophosphohydrolase HP432_RS17305 ENOG4105D3W isochorismatase HP432_RS17310 ENOG41081XQ Conserved Protein HP432_RS17315 ENOG4105WJG Glutathione HP432_RS17330 ENOG4108J2R molybdopterin oxidoreductase HP432_RS17335 ENOG4105CUW cytochrome C-TYPE protein HP432_RS17345 ENOG4106ZCM YecM protein HP432_RS17350 ENOG4105C75 arginyL-tRNA synthetase HP432_RS17360 ENOG4105W13 flagellar protein HP432_RS17365 ENOG4105D7B Flagellar biosynthesis protein flha HP432_RS17370 ENOG4105D00 flagellar biosynthetic protein flhB HP432_RS17375 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HP432_RS17380 ENOG4108VYJ response regulator receiver protein HP432_RS17385 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HP432_RS17390 ENOG4105BZU Histidine kinase HP432_RS17395 ENOG4105C8Q Methyl-accepting chemotaxis HP432_RS17400 ENOG4105C8Q Methyl-accepting chemotaxis HP432_RS17405 ENOG4108V3W Chemotaxis protein, CheW HP432_RS17410 ENOG4105CBS Chea signal transduction histidine kinase HP432_RS17415 ENOG4105ER2 Ompa motb domain protein HP432_RS17420 ENOG4107RD7 Flagellar Motor Protein, MotA HP432_RS17425 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HP432_RS17435 ENOG4108VA4 Universal stress protein HP432_RS17445 ENOG4108K4C ec 3.1.3.12 HP432_RS17450 ENOG4105CNN ABC, transporter HP432_RS17455 ENOG4105C2J ABC transporter HP432_RS17460 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HP432_RS17465 ENOG4108UEC Ferritin-like protein HP432_RS17470 ENOG4105N4N Protein of unknown function (DUF2766) HP432_RS17480 ENOG4105P23 (LipO)protein HP432_RS17485 ENOG41090A1 ferritin HP432_RS17490 ENOG4105VVZ metal-binding protein HP432_RS17495 ENOG4105E0U tyrosine-specific transport protein HP432_RS17500 ENOG4106RHG Yeca family HP432_RS17520 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HP432_RS17525 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP432_RS17550 ENOG4105DZR Type I site-specific deoxyribonuclease HP432_RS17555 ENOG4106RHG Yeca family HP432_RS17665 ENOG4105WH1 Two component transcriptional regulator luxr family HP432_RS17675 ENOG4105XVG cytoplasmic protein HP432_RS17680 ENOG4105VJY transcriptional regulator HP432_RS17685 ENOG4105CDA abc transporter atp-binding protein HP432_RS17690 ENOG4105E5Q amino acid AbC transporter HP432_RS17695 ENOG4105K6H D-cysteine desulfhydrase HP432_RS17700 ENOG4105EAB amino acid AbC transporter HP432_RS17705 ENOG4108M9K flagella biosynthesis protein FliZ HP432_RS17710 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP432_RS17715 ENOG4105I03 Flagellin HP432_RS17720 ENOG4105DTS flagellar hook-associated HP432_RS17725 ENOG4105MQ3 flagellar protein FliS HP432_RS17730 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HP432_RS17735 ENOG4105E5K Alpha-amylase HP432_RS17740 ENOG4108W9D (LipO)protein HP432_RS17745 ENOG41066VF YeeE YedE family protein HP432_RS17755 ENOG4108RAV Conserved protein HP432_RS17760 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HP432_RS17765 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HP432_RS17770 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HP432_RS17775 ENOG41090PJ Flagellar assembly protein HP432_RS17780 ENOG4108JIR Flagellum-specific ATP synthase HP432_RS17785 ENOG4105GSA Flagellar export protein flij HP432_RS17790 ENOG4105WF4 Flagellar hook-length control protein HP432_RS17795 ENOG4107ZI8 flagellar basal body-associated protein flil HP432_RS17800 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HP432_RS17805 ENOG4105DD5 Flagellar motor switch protein HP432_RS17810 ENOG4105K0P flagellar biosynthesis protein HP432_RS17815 ENOG4105CN7 Flagellar biosynthetic protein FliP HP432_RS17825 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HP432_RS17830 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HP432_RS17840 ENOG4105YX3 cellular response to acidity HP432_RS17855 ENOG4105VNZ cytoplasmic protein HP432_RS17860 ENOG4105CKW Inner membrane protein yedI HP432_RS17865 ENOG4105FDR Membrane HP432_RS17870 ENOG41090BB DNA mismatch endonuclease (vsr) HP432_RS17875 ENOG4105DVF Cytosine-specific methyltransferase HP432_RS17885 ENOG4105Y0K Inner membrane protein YedR HP432_RS17890 ENOG4105FCK Membrane HP432_RS17915 ENOG4107ZY3 Histidine kinase HP432_RS17920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP432_RS17925 ENOG4105VT2 5-hydroxyisourate hydrolase HP432_RS17930 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HP432_RS17940 ENOG4108MEK Metal-binding protein YodA HP432_RS17945 ENOG4108VKM cytochrome b561 HP432_RS17990 ENOG4105CSH Transporter HP432_RS17995 ENOG4105FYV Amp nucleosidase HP432_RS18000 ENOG4105CDY transcriptional regulatory protein HP432_RS18010 ENOG4105UQX Mate efflux family protein HP432_RS18020 ENOG4107R11 Transcriptional regulator HP432_RS18025 ENOG4106P55 Transcriptional regulator HP432_RS18050 ENOG4105E98 transcriptional regulator DeoR family HP432_RS18055 ENOG4108YZG isomerase HP432_RS18060 ENOG4105DT3 PTS system, galactitol-specific IIc component HP432_RS18065 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HP432_RS18070 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HP432_RS18080 ENOG4108PXI ErfK YbiS YcfS YnhG HP432_RS18085 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HP432_RS18095 ENOG4108YZT Adenosylcobinamide kinase HP432_RS18115 ENOG4105DR8 Membrane HP432_RS18125 ENOG4105DZ1 carboxypeptidase HP432_RS18130 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HP432_RS18135 ENOG4105CKK Glycosyl transferase, family 2 HP432_RS18145 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding HP432_RS18185 ENOG4105CJB Exodeoxyribonuclease I HP432_RS18195 ENOG4105CUC YeeE YedE family protein HP432_RS18200 ENOG4105CUB amino acid HP432_RS18210 ENOG4105EQ1 Transcriptional regulator HP432_RS18215 ENOG4107SRH Nad-dependent epimerase dehydratase HP432_RS18220 ENOG4105KRQ Addiction module toxin, Txe YoeB family HP432_RS18225 ENOG4105VTW prevent-host-death family HP432_RS18240 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HP432_RS18245 ENOG4105CIH Imidazole acetol-phosphate transaminase HP432_RS18250 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HP432_RS18255 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HP432_RS18285 ENOG4105C6Y Udp-glucose 6-dehydrogenase HP432_RS18290 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HP432_RS18305 ENOG4108RYC glycosyltransferase HP432_RS18335 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HP432_RS18340 ENOG4105DMT epimerase dehydratase HP432_RS18355 ENOG4107T8Q Glycosyl transferase (Group 1 HP432_RS18360 ENOG4105C74 pyruvyl transferase HP432_RS18365 ENOG4105PSV Polysaccharide Biosynthesis Protein HP432_RS18370 ENOG4105D3Q Sugar transferase HP432_RS18375 ENOG4107QKV phosphomannomutase HP432_RS18380 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HP432_RS18385 ENOG4106CD9 glycosyl transferase group 1 HP432_RS18390 ENOG4105FGF GDP-mannose mannosyl hydrolase HP432_RS18395 ENOG4105C30 Nad-dependent epimerase dehydratase HP432_RS18400 ENOG4105C0K Gdp-mannose 4,6-dehydratase HP432_RS18405 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HP432_RS18410 ENOG4105ECJ Glycosyl Transferase HP432_RS18415 ENOG4108NYJ Colanic acid HP432_RS18420 ENOG4107RXY Glycosyl transferase HP432_RS18425 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HP432_RS18430 ENOG41090RK glycosyl transferase HP432_RS18435 ENOG4105D75 Capsular exopolysaccharide family HP432_RS18440 ENOG4105KJF protein tyrosine phosphatase HP432_RS18445 ENOG4105DAY polysaccharide export protein HP432_RS18455 ENOG4105EE5 Membrane protein terC HP432_RS18460 ENOG4108GAE asmA family HP432_RS18470 ENOG4105DBI uridine monophosphokinase HP432_RS18475 ENOG4105BZU Histidine kinase HP432_RS18480 ENOG4105D03 DNA-3-methyladenine glycosylase II HP432_RS18485 ENOG4105R8A Heat shock protein HP432_RS18490 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HP432_RS18495 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HP432_RS18500 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HP432_RS18505 ENOG4108M24 von Willebrand factor, type A HP432_RS18525 ENOG4105BZS acriflavin resistance protein HP432_RS18540 ENOG4105EB3 Histidine kinase HP432_RS18545 ENOG4105E3W Two component transcriptional regulator (Winged helix family HP432_RS18550 ENOG4105KWI UPF0339 protein HP432_RS18555 ENOG4105CFP Peptidase U32 HP432_RS18560 ENOG41076Z6 Uncharacterized protein yegR HP432_RS18570 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HP432_RS18575 ENOG4105IE8 Alpha-ketoglutarate permease HP432_RS18580 ENOG4105CMG Carbohydrate kinase HP432_RS18585 ENOG4105DEI Mannitol dehydrogenase HP432_RS18605 ENOG4105EF1 ribulokinase HP432_RS18610 ENOG4105IE8 Alpha-ketoglutarate permease HP432_RS18615 ENOG4105EIE fructose-bisphosphate aldolase HP432_RS18620 ENOG4105EAA nucleoside HP432_RS18625 ENOG4108KD5 ADP-ribosylation crystallin J1 HP432_RS18630 ENOG4108TFM Kinase, PfkB family HP432_RS18635 ENOG4105FDP GntR family transcriptional regulator HP432_RS18640 ENOG4108UQ1 hydrolase, family 25 HP432_RS18645 ENOG4105DWF phosphomethylpyrimidine kinase HP432_RS18665 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HP432_RS18670 ENOG410662B Type-1 fimbrial protein HP432_RS18675 ENOG4105CW0 outer membrane usher protein HP432_RS18680 ENOG4108MQF Chaperone HP432_RS18685 ENOG41063W2 Fimbrial protein HP432_RS18690 ENOG41067AK Protein of unknown function (DUF2574) HP432_RS18695 ENOG4105D1F ATP-binding protein HP432_RS18700 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HP432_RS18705 ENOG4108KDT Molybdate metabolism regulator HP432_RS18710 ENOG4108KDT Molybdate metabolism regulator HP432_RS18720 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HP432_RS18725 ENOG4105RD5 HP432_RS18730 ENOG4105DEG Vwa containing coxe family protein HP432_RS18735 ENOG410903U zinc ion binding HP432_RS18740 ENOG4108YCW (LipO)protein HP432_RS18745 ENOG4108W15 Protein of unknown function (DUF1456) HP432_RS18750 ENOG4108NEV two component transcriptional regulator, LytTR family HP432_RS18755 ENOG4108HRK Histidine kinase HP432_RS18760 ENOG4108XDN Transcriptional regulator HP432_RS18770 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HP432_RS18775 ENOG4108IJ8 ABC transporter HP432_RS18780 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HP432_RS18785 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HP432_RS18790 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HP432_RS18795 ENOG4105CXG d-lactate dehydrogenase HP432_RS18800 ENOG41061WM D-Alanyl-D-Alanine HP432_RS18805 ENOG41069YE inner membrane protein yohC HP432_RS18810 ENOG4105KHU inner membrane protein YohD HP432_RS18815 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HP432_RS18820 ENOG4105ETP RND efflux system, outer membrane lipoprotein HP432_RS18830 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HP432_RS18840 ENOG41067MG lrgb family HP432_RS18850 ENOG4107GZ4 SanA protein HP432_RS18855 ENOG4105Y9N Membrane HP432_RS18860 ENOG4105BZ8 glutamate synthase HP432_RS18865 ENOG4107SJI Dehydrogenase HP432_RS18870 ENOG4108HWV )-transporter HP432_RS18875 ENOG4105C2J ABC transporter HP432_RS18880 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HP432_RS18885 ENOG41060NJ transcriptional regulator HP432_RS18890 ENOG4105DHF Membrane HP432_RS18905 ENOG4105D05 Receptor HP432_RS18910 ENOG4108IQI permease HP432_RS18915 ENOG4105DUM transcriptional regulator, lysR family HP432_RS18920 ENOG4105HMI Membrane HP432_RS18925 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HP432_RS18930 ENOG4105DD7 kinase (PfkB family HP432_RS18935 ENOG4105D9N nucleoside HP432_RS18950 ENOG4105DM4 PTS System HP432_RS18955 ENOG4105DE4 1-phosphofructokinase HP432_RS18960 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HP432_RS18965 ENOG4105S8Q sugar efflux transporter HP432_RS18970 ENOG4105KRS Proteinase inhibitor HP432_RS18980 ENOG4105DEI Mannitol dehydrogenase HP432_RS18985 ENOG4105CKI cobalamin synthesis protein HP432_RS18990 ENOG41076MN Phosphoesterase, PA-phosphatase related HP432_RS18995 ENOG4107TT5 NLP P60 protein HP432_RS19000 ENOG4105CXC rtn protein HP432_RS19005 ENOG4105E43 Extracellular solute-binding protein, family 5 HP432_RS19010 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HP432_RS19015 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HP432_RS19020 ENOG4108JQ5 ABC transporter HP432_RS19025 ENOG4105HG6 HP432_RS19030 ENOG4105C2C drug resistance transporter, Bcr CflA HP432_RS19035 ENOG4105I08 Pseudouridine synthase HP432_RS19040 ENOG4105CFI type iii restriction protein res subunit HP432_RS19060 ENOG4105E68 Sulfatase HP432_RS19070 ENOG4108MGN ATP-binding component of a transport system HP432_RS19075 ENOG4105WH1 Two component transcriptional regulator luxr family HP432_RS19080 ENOG4105KWW Biogenesis protein HP432_RS19085 ENOG4107QX9 Thiol disulfide interChange protein HP432_RS19090 ENOG4105DA4 cytochrome c-type biogenesis protein HP432_RS19100 ENOG4105X3C heme exporter protein HP432_RS19105 ENOG41060IM Heme exporter protein HP432_RS19110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HP432_RS19115 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HP432_RS19120 ENOG4105CUW cytochrome C-TYPE protein HP432_RS19125 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HP432_RS19130 ENOG4105GXZ Ferredoxin-type protein NapH HP432_RS19135 ENOG4108BGM Quinol dehydrogenase periplasmic component HP432_RS19145 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HP432_RS19150 ENOG4108ZNS ferredoxin-type protein NapF HP432_RS19165 ENOG4105DWT malate dehydrogenase (quinone) HP432_RS19170 ENOG4105IBP Cyclic peptide transporter HP432_RS19175 ENOG4105CF1 Alkylated DNA repair protein HP432_RS19180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HP432_RS19185 ENOG4105CJ2 (LipO)protein HP432_RS19190 ENOG4105FCK Membrane HP432_RS19195 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HP432_RS19200 ENOG41068CG regulatoR HP432_RS19205 ENOG4105BZU Histidine kinase HP432_RS19210 ENOG4105BZU Histidine kinase HP432_RS19220 ENOG4107QP7 CoA-transferase subunit A HP432_RS19225 ENOG4107QNJ CoA-transferase subunit B HP432_RS19230 ENOG4105CRW Short chain fatty acid transporter HP432_RS19235 ENOG4105CHU acetyl-coa acetyltransferase HP432_RS19240 ENOG4105EDV vault protein HP432_RS19245 ENOG41081SK signal peptide protein HP432_RS19250 ENOG4107S52 alpha-2-macroglobulin domain protein HP432_RS19255 ENOG4108QJJ Protein of unknown function (DUF1175) HP432_RS19260 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HP432_RS19265 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP432_RS19275 ENOG4107GHC outer membrane autotransporter HP432_RS19285 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP432_RS19290 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP432_RS19295 ENOG4105XPH Ferredoxin HP432_RS19300 ENOG4105FQR PH-inducible protein involved in stress response HP432_RS19310 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HP432_RS19315 ENOG4105CXY transporter HP432_RS19320 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HP432_RS19325 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HP432_RS19330 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HP432_RS19335 ENOG4105DNE Transposase HP432_RS19350 ENOG4105CSP Major Facilitator Superfamily HP432_RS19355 ENOG4105CXK mandelate racemase muconate lactonizing HP432_RS19360 ENOG4107258 Transcriptional regulator HP432_RS19365 ENOG4108EWA cinA-like protein HP432_RS19370 ENOG4108UII YfaZ family HP432_RS19375 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HP432_RS19380 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) HP432_RS19400 ENOG4105C3I Nad-dependent epimerase dehydratase HP432_RS19410 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HP432_RS19425 ENOG4106GZG polymyxin resistance protein B HP432_RS19430 ENOG4105CEY Amp-dependent synthetase and ligase HP432_RS19440 ENOG4108IPT Naphthoate synthase HP432_RS19455 ENOG4105E4F Isochorismate synthase HP432_RS19460 ENOG4105TNS Conserved Protein HP432_RS19465 ENOG4107YB6 acetyltransferase, (GNAT) family HP432_RS19480 ENOG4106HDC HP432_RS19490 ENOG4105C8S subunit m HP432_RS19495 ENOG4105D65 subunit l HP432_RS19505 ENOG4107UFS subunit j HP432_RS19520 ENOG4107R0R NADH dehydrogenase subunit g HP432_RS19525 ENOG4107QIZ NADH dehydrogenase HP432_RS19530 ENOG4105GKE subunit e HP432_RS19550 ENOG4107NQ8 LysR family Transcriptional regulator HP432_RS19555 ENOG4105CHM Aminotransferase HP432_RS19560 ENOG4105DK2 UPF0207 protein HP432_RS19565 ENOG4107QWE )-transporter HP432_RS19570 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HP432_RS19575 ENOG4105XWI UPF0304 protein HP432_RS19585 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HP432_RS19590 ENOG4105C6K Malic enzyme HP432_RS19595 ENOG4105CSX c4-dicarboxylate anaerobic carrier HP432_RS19600 ENOG4105PTV Nudix Hydrolase HP432_RS19605 ENOG4108RE9 Phosphodiesterase HP432_RS19610 ENOG4108SHQ Glutathione S-transferase HP432_RS19615 ENOG4105CYM Glutathione S-transferase HP432_RS19620 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HP432_RS19625 ENOG4105ECP epimerase HP432_RS19630 ENOG4105DNE Transposase HP432_RS19635 ENOG4108JEH abc transporter atp-binding protein HP432_RS19640 ENOG4106YG3 ABC transporter HP432_RS19645 ENOG4105DSP amino acid AbC transporter HP432_RS19650 ENOG4105E89 ABC transporter HP432_RS19655 ENOG4105E89 ABC transporter HP432_RS19660 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HP432_RS19665 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HP432_RS19670 ENOG4105E96 Colicin v production protein HP432_RS19675 ENOG4108S3P Sporulation domain protein HP432_RS19680 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HP432_RS19690 ENOG4105DQR SNARE associated Golgi HP432_RS19700 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HP432_RS19710 ENOG4106WZ1 flagella biosynthesis regulator HP432_RS19715 ENOG4105F9N Major Facilitator Superfamily HP432_RS19720 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HP432_RS19725 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HP432_RS19730 ENOG4105MH2 YfcL protein HP432_RS19735 ENOG4108BPE -transporting atpase HP432_RS19740 ENOG4105EJ9 Membrane HP432_RS19755 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HP432_RS19770 ENOG4105US4 fimbrial-like protein yfcP HP432_RS19775 ENOG4105UGQ Fimbrial HP432_RS19780 ENOG4105NEV Fimbrial HP432_RS19785 ENOG4108FZ9 Chaperone HP432_RS19790 ENOG4106PG1 outer membrane usher protein HP432_RS19800 ENOG4108BY2 phosphohistidine phosphatase HP432_RS19815 ENOG4105KZW UPF0381 protein HP432_RS19820 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HP432_RS19840 ENOG410903C (LipO)protein HP432_RS19845 ENOG4105S64 Formate nitrite transporter HP432_RS19855 ENOG4105W8I Transcriptional regulator HP432_RS19860 ENOG4105C6Z Gluconate HP432_RS19865 ENOG4105BZC d-serine deaminase HP432_RS19870 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP432_RS19875 ENOG4105CW7 secretion protein, HlyD family HP432_RS19880 ENOG4108WQH regulatoR HP432_RS19885 ENOG4105BZU Histidine kinase HP432_RS19890 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HP432_RS19895 ENOG4108N2Y auxin Efflux HP432_RS19900 ENOG4105CFN oxalyl-CoA decarboxylase HP432_RS19910 ENOG4108V08 YfdX protein HP432_RS19920 ENOG4105W9M Membrane HP432_RS19925 ENOG4105D1S lipid A biosynthesis HP432_RS19935 ENOG4105CHM Aminotransferase HP432_RS19940 ENOG4108HRK Histidine kinase HP432_RS19945 ENOG4105DY9 regulatoR HP432_RS19950 ENOG4108CIP transcriptional regulator HP432_RS19955 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HP432_RS19960 ENOG4105CN9 Peptidase m42 family protein HP432_RS19965 ENOG4105DC7 peptidase M24 HP432_RS19970 ENOG410863U PTS System HP432_RS19975 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HP432_RS19985 ENOG4105VCT ion-transport protein YfeO HP432_RS19990 ENOG4109076 Conserved Protein HP432_RS20000 ENOG4105D9N nucleoside HP432_RS20005 ENOG4108KMM Diguanylate cyclase HP432_RS20020 ENOG4105HZG regulatoR HP432_RS20025 ENOG4105GXM Putative transcription regulator (DUF1323) HP432_RS20055 ENOG4105CN8 Transcriptional regulator HP432_RS20065 ENOG4105EAA nucleoside HP432_RS20070 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HP432_RS20075 ENOG4108NFH Sugar hydrolase HP432_RS20080 ENOG4108M0I Transcriptional regulator HP432_RS20085 ENOG4105DHU Bile acid HP432_RS20090 ENOG4105VRT cytoplasmic protein HP432_RS20110 ENOG4105C6T cysteine synthase HP432_RS20120 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HP432_RS20125 ENOG4105C5Y PTS System HP432_RS20135 ENOG4105M0Y HP432_RS20140 ENOG4105WEC Molybdate metabolism regulator HP432_RS20145 ENOG4105C6T cysteine synthase HP432_RS20150 ENOG4108IJ6 ABC transporter HP432_RS20155 ENOG4105ECW sulfate abc transporter HP432_RS20160 ENOG4108I5D sulfate abc transporter HP432_RS20165 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HP432_RS20170 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HP432_RS20185 ENOG4105C5Y PTS System HP432_RS20190 ENOG4107S1E Beta-lactamase HP432_RS20195 ENOG4105EZR dyp-type peroxidase family protein HP432_RS20200 ENOG4105E7K (LipO)protein HP432_RS20205 ENOG4105QZU Inner membrane protein YfeZ HP432_RS20215 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HP432_RS20225 ENOG4108K3Z AraC family transcriptional regulator HP432_RS20230 ENOG4108X49 Ethanolamine utilization protein EutK HP432_RS20235 ENOG4106D67 ethanolamine utilization protein HP432_RS20245 ENOG4105CPD ethanolamine ammonia-lyase HP432_RS20250 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HP432_RS20255 ENOG4105ENY Ethanolamine utilization protein eutH HP432_RS20260 ENOG4105C0A alcohol dehydrogenase HP432_RS20265 ENOG4107RWI ethanolamine utilization protein eutJ HP432_RS20270 ENOG4108EKI Dehydrogenase HP432_RS20275 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HP432_RS20280 ENOG4105KNY Microcompartments protein HP432_RS20285 ENOG4107WUY phosphate acetyltransferase HP432_RS20290 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HP432_RS20295 ENOG4105NDK ethanolamine utilization protein HP432_RS20300 ENOG4106S4J ethanolamine utilization protein EutP HP432_RS20305 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HP432_RS20310 ENOG4105C6K Malic enzyme HP432_RS20315 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP432_RS20320 ENOG4105CV1 Transketolase (EC 2.2.1.1) HP432_RS20325 ENOG4108PVD exported protein HP432_RS20335 ENOG4105BZ8 glutamate synthase HP432_RS20340 ENOG4105BZU Histidine kinase HP432_RS20345 ENOG4105BZS acriflavin resistance protein HP432_RS20360 ENOG4105KUZ arsenate reductase HP432_RS20375 ENOG4106KED esterase YpfH HP432_RS20385 ENOG4105CGZ zinc metallopeptidase HP432_RS20395 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HP432_RS20405 ENOG4105RH4 Glycine cleavage system transcriptional repressor HP432_RS20410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HP432_RS20415 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HP432_RS20425 ENOG4107TDF Formate hydrogenlyase subunit 4 HP432_RS20430 ENOG4105D65 subunit l HP432_RS20435 ENOG4107WQX hydrogenase 4 membrane subunit HP432_RS20445 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HP432_RS20455 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HP432_RS20460 ENOG4105I6X formate hydrogenlyase maturation HP432_RS20465 ENOG4108JUA Transcriptional regulator HP432_RS20470 ENOG4105TMB Formate nitrite transporter HP432_RS20475 ENOG4105C02 permease HP432_RS20480 ENOG4105ERG peptidase m48, ste24p HP432_RS20485 ENOG4105K89 arsenate reductase HP432_RS20490 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HP432_RS20495 ENOG4105C2W permease HP432_RS20510 ENOG4108V3E phosphoribosylglycinamide formyltransferase HP432_RS20515 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HP432_RS20520 ENOG4105C9X ppx gppa phosphatase HP432_RS20525 ENOG4105BZU Histidine kinase HP432_RS20535 ENOG41062G3 Protein of unknown function (DUF2633) HP432_RS20540 ENOG4108ZMA Outer membrane lipoprotein HP432_RS20545 ENOG41066DY Membrane HP432_RS20555 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HP432_RS20565 ENOG4105VPD cellular component movement HP432_RS20580 ENOG4105N21 Membrane HP432_RS20610 ENOG4108JQB penicillin-binding protein 1C HP432_RS20615 ENOG4105DN3 alpha-2-macroglobulin domain protein HP432_RS20620 ENOG4105KHC sulfurtransferase HP432_RS20625 ENOG4105YYA enhanced serine sensitivity protein SseB HP432_RS20630 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HP432_RS20635 ENOG4105WVQ Fe-S assembly protein IscX HP432_RS20640 ENOG4108ZIT Ferredoxin, 2FE-2S HP432_RS20660 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HP432_RS20680 ENOG4105ECY inositol monophosphatase HP432_RS20685 ENOG4107XM9 (LipO)protein HP432_RS20690 ENOG4108MN2 Stationary phase inducible protein CsiE HP432_RS20695 ENOG4105D8G Major Facilitator superfamily HP432_RS20700 ENOG4108W5M transcriptional regulator HP432_RS20705 ENOG4105FUY alpha subunit HP432_RS20730 ENOG4108SB3 DoxX Family HP432_RS20735 ENOG4108ZKT aldose 1-epimerase HP432_RS20740 ENOG4105CPQ Dehydrogenase HP432_RS20745 ENOG4105CNN ABC, transporter HP432_RS20750 ENOG4108F37 ATP-binding component of a transport system HP432_RS20755 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HP432_RS20760 ENOG4107HQ7 repeat protein HP432_RS20765 ENOG4108NZE NAGC-like transcriptional regulator HP432_RS20775 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HP432_RS20785 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HP432_RS20790 ENOG4108SKK alpha helix protein HP432_RS20795 ENOG4107WP9 Histidine kinase HP432_RS20800 ENOG4107QIK phosphoribosylformylglycinamidine synthase HP432_RS20810 ENOG4108Z6B deaminase HP432_RS20815 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HP432_RS20820 ENOG4106G6Q Transcriptional regulator HP432_RS20825 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HP432_RS20840 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HP432_RS20860 ENOG4105C3F Signal peptidase i HP432_RS20870 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HP432_RS20875 ENOG4105VQK sigma E regulatory protein, MucB RseB HP432_RS20880 ENOG41069PW sigma-e factor negative regulatory protein HP432_RS20885 ENOG4105EMN RNA polymerase sigma factor HP432_RS20895 ENOG4108IYU L-aspartate oxidase HP432_RS20905 ENOG4105C1J atp-dependent rna helicase HP432_RS20910 ENOG41090KR LysR family transcriptional Regulator HP432_RS20935 ENOG4105EIB trna rrna methyltransferase HP432_RS20940 ENOG4105K63 Thioredoxin HP432_RS20945 ENOG4106IUH DTW domain containing protein HP432_RS20950 ENOG4105CD5 CoA-binding domain protein HP432_RS20955 ENOG4105JIM Phosphatidylserine synthase HP432_RS20960 ENOG4105T42 (LipO)protein HP432_RS20965 ENOG4105CSH Transporter HP432_RS20990 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HP432_RS20995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HP432_RS21000 ENOG4105C34 Pseudouridine synthase HP432_RS21005 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HP432_RS21010 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HP432_RS21020 ENOG4105CQC Prephenate dehydratase HP432_RS21025 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HP432_RS21030 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HP432_RS21035 ENOG4105QP9 Protein of unknown function (DUF2799) HP432_RS21040 ENOG4108WS1 HP432_RS21045 ENOG4108KHX Diguanylate cyclase HP432_RS21050 ENOG41090EK ompa motb domain protein HP432_RS21075 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HP432_RS21080 ENOG4106KVJ cytochrome C assembly protein HP432_RS21085 ENOG4108JU6 CBS domain protein HP432_RS21100 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HP432_RS21105 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HP432_RS21115 ENOG4108Z1B Cyclase dehydrase HP432_RS21130 ENOG4105DFP Integrase HP432_RS21140 ENOG4105FA0 parb-like partition protein HP432_RS21160 ENOG4105E54 alpha-amylase HP432_RS21175 ENOG4105D5U fad dependent oxidoreductase HP432_RS21180 ENOG4105C26 Dehydrogenase HP432_RS21185 ENOG4108JPW Aminotransferase HP432_RS21190 ENOG4105C85 amino acid HP432_RS21195 ENOG4108PVQ transcriptional regulator HP432_RS21200 ENOG4109066 lysm domain bon superfamily protein HP432_RS21205 ENOG4105VPI YqaE family transport protein HP432_RS21210 ENOG41080HT Transcriptional regulator, arsr family HP432_RS21215 ENOG4108V62 Rhodanese domain protein HP432_RS21220 ENOG4108X73 DNA- binding protein HP432_RS21225 ENOG4108RNS Exports L-alanine (By similarity) HP432_RS21230 ENOG4108WMJ Protein of unknown function (DUF2002) HP432_RS21235 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HP432_RS21240 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HP432_RS21250 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP432_RS21255 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP432_RS21260 ENOG4108IJ7 Glycine betaine HP432_RS21265 ENOG4108HQS Glycine betaine HP432_RS21270 ENOG4105GIJ Glycine betaine HP432_RS21280 ENOG4108UMN azlc family HP432_RS21285 ENOG4105ZED uncharacterized protein ygaH HP432_RS21290 ENOG4105NTK Transcriptional repressor Mpra HP432_RS21295 ENOG4105CW7 secretion protein, HlyD family HP432_RS21300 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP432_RS21315 ENOG4105W39 Membrane HP432_RS21320 ENOG4107VXZ Hydrolase HP432_RS21355 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HP432_RS21375 ENOG4107TH8 cina domain protein HP432_RS21385 ENOG4105CVE Lytic murein transglycosylase HP432_RS21390 ENOG410787A Pts system, glucitol sorbitol-specific HP432_RS21395 ENOG4105DZY Pts system, glucitol sorbitol-specific HP432_RS21400 ENOG4105VI0 Pts system, glucitol sorbitol-specific HP432_RS21405 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HP432_RS21410 ENOG4105J92 DNA-binding transcriptional activator GutM HP432_RS21415 ENOG410804X Transcriptional regulator HP432_RS21425 ENOG4108JUA Transcriptional regulator HP432_RS21430 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HP432_RS21435 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HP432_RS21440 ENOG4105C8H hydrogenase maturation protein Hypf HP432_RS21445 ENOG4108RC0 Electron transport protein HP432_RS21450 ENOG4105DDV Transcriptional regulator (LacI family HP432_RS21455 ENOG4105C5Y PTS System HP432_RS21460 ENOG4105CS2 ec 3.2.1.21 HP432_RS21465 ENOG4108MG9 hydrogenase 3 maturation protease HP432_RS21470 ENOG4105I6X formate hydrogenlyase maturation HP432_RS21475 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HP432_RS21480 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HP432_RS21485 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HP432_RS21490 ENOG4107TDF Formate hydrogenlyase subunit 4 HP432_RS21495 ENOG4107R30 NADH dehydrogenase HP432_RS21500 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HP432_RS21505 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HP432_RS21510 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HP432_RS21515 ENOG4107RSS Hydrogenase accessory protein HypB HP432_RS21520 ENOG41083WG hydrogenase assembly chaperone HP432_RS21525 ENOG4105CQS hydrogenase expression formation protein HypD HP432_RS21530 ENOG4105C45 hydrogenase expression formation protein (HypE) HP432_RS21535 ENOG4108JUA Transcriptional regulator HP432_RS21540 ENOG4105VXR cytoplasmic protein HP432_RS21555 ENOG4105MEW serine threonine protein phosphatase HP432_RS21560 ENOG4105MVE transcriptional regulator HP432_RS21565 ENOG4105ZXK Dehydrogenase HP432_RS21570 ENOG4105G63 Type III effector Hrp-dependent HP432_RS21575 ENOG4105FB2 class II Aldolase HP432_RS21580 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HP432_RS21585 ENOG4105C6Z Gluconate HP432_RS21590 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP432_RS21595 ENOG4108K5P (LipO)protein HP432_RS21630 ENOG4105N0Z inner membrane protein ygbE HP432_RS21650 ENOG4108MXK alkaline phosphatase isozyme conversion HP432_RS21655 ENOG4105PWE CRISPR-associated protein cas2 HP432_RS21660 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HP432_RS21665 ENOG4108Y7V CRISPR-associated protein, Cse3 family HP432_RS21670 ENOG4108VWQ crispr-associated protein HP432_RS21675 ENOG41060M0 Crispr-associated protein, cse4 family HP432_RS21680 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HP432_RS21685 ENOG4105CYR Crispr-associated protein, cse1 family HP432_RS21690 ENOG4105DTT CRISPR-associated helicase, cas3 HP432_RS21700 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HP432_RS21710 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HP432_RS21715 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HP432_RS21720 ENOG4105WQV ferredoxin-like protein HP432_RS21725 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HP432_RS21730 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HP432_RS21735 ENOG4106IKH Electron transfer flavoprotein HP432_RS21740 ENOG4105C54 Major Facilitator superfamily HP432_RS21745 ENOG4107R3A FAD linked oxidase domain protein HP432_RS21750 ENOG4105CHR reductase HP432_RS21755 ENOG4108ITV Inner membrane protein yqcE HP432_RS21760 ENOG4108CWB sugar kinase ygcE HP432_RS21765 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HP432_RS21775 ENOG4105HA9 of methanol dehydrogenase type HP432_RS21790 ENOG4105DXN mazG family HP432_RS21795 ENOG4105MZG transcriptional modulator of maze toxin, mazf HP432_RS21800 ENOG4106A2Z transcriptional regulator antitoxin, MazE HP432_RS21805 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HP432_RS21815 ENOG4105BZU Histidine kinase HP432_RS21820 ENOG4105EQX glucarate dehydratase HP432_RS21825 ENOG4105EQX glucarate dehydratase HP432_RS21830 ENOG4105DJB Major Facilitator Superfamily HP432_RS21835 ENOG4105QDK Flavodoxin HP432_RS21840 ENOG4105DR9 pseudouridine synthase HP432_RS21845 ENOG4105WP7 tRNA pseudouridine synthase C HP432_RS21860 ENOG4105EWT decarboxylase family HP432_RS21865 ENOG4105C44 Serine transporter HP432_RS21870 ENOG4105EJQ L-serine dehydratase HP432_RS21880 ENOG4105C0A alcohol dehydrogenase HP432_RS21885 ENOG4107W7X Aldolase HP432_RS21890 ENOG4105EDR glucose galactose transporter HP432_RS21895 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HP432_RS21900 ENOG4105CMG Carbohydrate kinase HP432_RS21905 ENOG4105CMG Carbohydrate kinase HP432_RS21915 ENOG4107EDW L-fucose operon activator HP432_RS21925 ENOG4105M08 Membrane HP432_RS21930 ENOG4105ETT transcriptional Regulator, LysR family HP432_RS21935 ENOG4105M5B (LipO)protein HP432_RS21940 ENOG4105C9B Cysteine desulfurase HP432_RS21945 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HP432_RS21950 ENOG4105CUZ uba thif-type nad fad binding protein HP432_RS21955 ENOG4105CA3 membrane-bound lytic murein transglycosylase HP432_RS21975 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HP432_RS21980 ENOG4108EKC n-acetylglutamate synthase HP432_RS21985 ENOG4107QYX exodeoxyribonuclease v alpha HP432_RS21990 ENOG4107QKA exodeoxyribonuclease V beta HP432_RS21995 ENOG4107QXK peptidase HP432_RS22000 ENOG4105DSY exodeoxyribonuclease V, gamma HP432_RS22005 ENOG4105RVB Prepilin peptidase dependent protein c HP432_RS22010 ENOG4105SEN Protein of unknown function (DUF2509) HP432_RS22015 ENOG4105JCS prepilin peptidase dependent protein HP432_RS22020 ENOG4105IPU prepilin peptidase dependent protein A HP432_RS22035 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HP432_RS22050 ENOG4105EE5 Membrane protein terC HP432_RS22055 ENOG4105SUV lipoprotein YgdR HP432_RS22060 ENOG4105CPC Aldo Keto reductase HP432_RS22065 ENOG4107S74 Lysophospholipid transporter LplT HP432_RS22075 ENOG41060NJ transcriptional regulator HP432_RS22085 ENOG4105RQF LysR family Transcriptional regulator HP432_RS22095 ENOG4107QNK )-transporter HP432_RS22100 ENOG4105CHR reductase HP432_RS22110 ENOG4105CHU acetyl-coa acetyltransferase HP432_RS22115 ENOG4108MHD transport protein HP432_RS22135 ENOG4108K5P (LipO)protein HP432_RS22140 ENOG4105C7W Xanthine dehydrogenase HP432_RS22145 ENOG4108HR6 Dehydrogenase HP432_RS22150 ENOG4108UTP (2Fe-2S)-binding domain protein HP432_RS22155 ENOG4108JUB Transcriptional regulator HP432_RS22170 ENOG4105IW6 Carbamoyltransferase HP432_RS22175 ENOG4107RCH Diaminopropionate ammonia-lyase HP432_RS22180 ENOG4107S4Y M20 DapE family protein YgeY HP432_RS22195 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HP432_RS22200 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HP432_RS22205 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HP432_RS22210 ENOG4105BZ8 glutamate synthase HP432_RS22215 ENOG4107UUR Chlorohydrolase aminohydrolase HP432_RS22220 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HP432_RS22230 ENOG4105C2W permease HP432_RS22235 ENOG4107QUY Guanine deaminase HP432_RS22240 ENOG4105C7N Xanthine uracil vitamin C permease HP432_RS22245 ENOG4108R8B oxidoreductase Fe-S subunit HP432_RS22250 ENOG4105BZ8 glutamate synthase HP432_RS22255 ENOG4105C2W permease HP432_RS22275 ENOG4105CRK lysyL-tRNA synthetase HP432_RS22285 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HP432_RS22290 ENOG4105T95 Thiol disulfide interChange protein HP432_RS22295 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HP432_RS22300 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HP432_RS22305 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HP432_RS22310 ENOG4105Y75 tpr repeat protein HP432_RS22320 ENOG4108UT2 hemolysin iii HP432_RS22330 ENOG4105CS2 ec 3.2.1.21 HP432_RS22335 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HP432_RS22340 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HP432_RS22360 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HP432_RS22365 ENOG4105D0A hydroxylase HP432_RS22370 ENOG4107RAQ aminopeptidase HP432_RS22390 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HP432_RS22400 ENOG4108JQ1 Dehydrogenase HP432_RS22420 ENOG4105D5P Methylmalonyl-coA mutase HP432_RS22425 ENOG4105DJT lAO AO transport system ATPase HP432_RS22430 ENOG4108M7F enoyl-CoA hydratase isomerase HP432_RS22435 ENOG4105CYC Transferase HP432_RS22440 ENOG4105DEQ transcriptional regulator HP432_RS22445 ENOG4105MPN Membrane HP432_RS22450 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HP432_RS22455 ENOG4105D64 Mechanosensitive ion channel HP432_RS22460 ENOG4105D2N Aldolase HP432_RS22475 ENOG4107Z1W Fructose transport system kinase HP432_RS22480 ENOG4108R4K DNA-binding, transcriptional regulator HP432_RS22485 ENOG4108Q8A Fructose-1,6-bisphosphatase HP432_RS22490 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HP432_RS22495 ENOG4105CTS PTS system mannitol-specific HP432_RS22500 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HP432_RS22505 ENOG4105CV1 Transketolase (EC 2.2.1.1) HP432_RS22510 ENOG4108K0D peptidase, M48 HP432_RS22520 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HP432_RS22540 ENOG4107QNK )-transporter HP432_RS22550 ENOG4105RWS endonuclease I HP432_RS22555 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HP432_RS22560 ENOG4105D7Z glutathione synthase HP432_RS22575 ENOG4105CZX twitching motility protein HP432_RS22580 ENOG4105DFA alanine racemase domain protein HP432_RS22585 ENOG4108VIA integral membrane protein HP432_RS22595 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HP432_RS22600 ENOG4105CSA Coproporphyrinogen iii oxidase HP432_RS22605 ENOG4106MH3 alpha helix chain HP432_RS22610 ENOG4105HDK L-asparaginase HP432_RS22615 ENOG4105K33 Periplasmic Protein HP432_RS22620 ENOG41090ED Protein with unknown function (DUF469) HP432_RS22630 ENOG4105CEN a g-specific adenine glycosylase HP432_RS22645 ENOG4105EAA nucleoside HP432_RS22650 ENOG4105CXN decarboxylase HP432_RS22655 ENOG4108UQV Membrane HP432_RS22670 ENOG4108I6E Sulfatase HP432_RS22675 ENOG4105T40 surface antigen msp4 family protein HP432_RS22695 ENOG4108S55 polysaccharide biosynthesis protein HP432_RS22700 ENOG4106FPV ATP-binding protein YghR HP432_RS22705 ENOG4108NDC ATP-binding protein yghS HP432_RS22710 ENOG4108GH0 ATP-binding protein yghT HP432_RS22715 ENOG4105CJ3 phosphate transporter HP432_RS22720 ENOG4106032 Glutathionylspermidine synthase HP432_RS22725 ENOG4105CYM Glutathione S-transferase HP432_RS22730 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HP432_RS22735 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HP432_RS22740 ENOG4108WGS hydrogenase 2-specific chaperone HP432_RS22745 ENOG4108USZ hydrogenase HP432_RS22750 ENOG4105DPX Hydrogenase, large subunit HP432_RS22755 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HP432_RS22760 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP432_RS22765 ENOG4105E3S small subunit HP432_RS22770 ENOG410900S Protein of unknown function (DUF2623) HP432_RS22780 ENOG4105CPC Aldo Keto reductase HP432_RS22790 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HP432_RS22795 ENOG4108ZZF transport protein (ExbD) HP432_RS22800 ENOG4105CWK Biopolymer transport protein, ExbB HP432_RS22805 ENOG4105C28 cystathionine HP432_RS22810 ENOG4108K81 inner membrane protein YghB HP432_RS22815 ENOG4105CF7 AraC family transcriptional regulator HP432_RS22820 ENOG4108I6A alcohol dehydrogenase HP432_RS22825 ENOG4105CV8 reductase HP432_RS22850 ENOG4105CCT upf0313 protein HP432_RS22855 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HP432_RS22860 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HP432_RS22865 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP432_RS22870 ENOG4108J59 Extracellular solute-binding protein, family 5 HP432_RS22875 ENOG4105WJ3 XRE family Transcriptional regulator HP432_RS22880 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HP432_RS22885 ENOG4105F4I Transcriptional regulator HP432_RS22890 ENOG4105H4F exported protein HP432_RS22895 ENOG4105XJC Two component transcriptional regulator (Winged helix family HP432_RS22900 ENOG4105DHQ Histidine kinase HP432_RS22905 ENOG4107DEU Inner membrane protein YgiZ HP432_RS22910 ENOG4105NF4 modulator of drug activity HP432_RS22915 ENOG4105VRH Antibiotic biosynthesis monooxygenase HP432_RS22920 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP432_RS22925 ENOG4105IPS esterase HP432_RS22930 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HP432_RS22935 ENOG4108SX3 cytoplasmic protein HP432_RS22940 ENOG41087AY ADP-Ribose pyrophosphatase HP432_RS22945 ENOG4105DFG type I secretion outer membrane protein HP432_RS22955 ENOG4106032 Glutathionylspermidine synthase HP432_RS22960 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HP432_RS22980 ENOG4105W0Z cytoplasmic protein HP432_RS22985 ENOG4105H8W Fimbrial protein