locus-tag class description HP433_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HP433_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP433_RS00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HP433_RS00030 ENOG410667J hydrolase HP433_RS00035 ENOG410657R replicase EC 2.7 HP433_RS00040 ENOG4105EMF GntR family transcriptional regulator HP433_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HP433_RS00050 ENOG4108RTU Aldolase HP433_RS00060 ENOG4105DJB Major Facilitator Superfamily HP433_RS00070 ENOG4105D99 atp gtp-binding protein HP433_RS00075 ENOG4105R2A (LipO)protein HP433_RS00095 ENOG4105FDP GntR family transcriptional regulator HP433_RS00100 ENOG4105CI1 PTS System HP433_RS00110 ENOG4108AHD Transcriptional regulator HP433_RS00115 ENOG4107RUZ Sss sodium solute transporter superfamily HP433_RS00120 ENOG4105CBG Sulfatase HP433_RS00125 ENOG4106DRA Inner membrane protein YidI HP433_RS00130 ENOG4105VG5 Membrane HP433_RS00135 ENOG4105JP4 Inner membrane protein yidG HP433_RS00140 ENOG4105J13 transcriptional regulator HP433_RS00145 ENOG4105E5M Multidrug resistance protein D HP433_RS00160 ENOG4105C7K acetolactate synthase HP433_RS00165 ENOG4105M71 acetolactate synthase 1 regulatory subunit HP433_RS00170 ENOG4108KX4 response regulator HP433_RS00175 ENOG4105BZU Histidine kinase HP433_RS00180 ENOG4105CXY transporter HP433_RS00185 ENOG4105CXY transporter HP433_RS00190 ENOG4105CPN adenine deaminase HP433_RS00195 ENOG4105C7N Xanthine uracil vitamin C permease HP433_RS00200 ENOG4108SAJ Protein of unknown function (DUF1198) HP433_RS00210 ENOG4105T8A Uncharacterized protein YicS HP433_RS00215 ENOG4105D01 (LipO)protein HP433_RS00220 ENOG4108UZ3 Transporter HP433_RS00225 ENOG4105S8Q sugar efflux transporter HP433_RS00240 ENOG4105CT4 transporter HP433_RS00245 ENOG4105CJQ hydrolase, family 31 HP433_RS00250 ENOG4105JV1 AsmA family HP433_RS00255 ENOG4105C2W permease HP433_RS00260 ENOG4105D6U Sodium Glutamate Symporter HP433_RS00270 ENOG4105CB5 ATP-dependent DNA helicase recG HP433_RS00275 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HP433_RS00280 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HP433_RS00290 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HP433_RS00300 ENOG4105EN6 Membrane HP433_RS00305 ENOG4105F5P DNA-damage-inducible protein d HP433_RS00310 ENOG4105DSJ YicC domain protein HP433_RS00330 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HP433_RS00335 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HP433_RS00345 ENOG4105KDC 50s ribosomal protein l28 HP433_RS00365 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HP433_RS00370 ENOG4105DKP glycosyl transferase, family 9 HP433_RS00375 ENOG4107RJ7 Glycosyl transferase (Group 1 HP433_RS00380 ENOG4107543 (lipo)polysaccharide HP433_RS00385 ENOG4106AH0 Glycosyl Transferase HP433_RS00390 ENOG4108PDR lipopolysaccharide core biosynthesis protein HP433_RS00395 ENOG4105X1N Glycosyl transferase family 8 HP433_RS00400 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HP433_RS00405 ENOG4108FRV O-antigen ligase HP433_RS00410 ENOG4105D16 lipopolysaccharide heptosyltransferase i HP433_RS00415 ENOG4105XA0 heptosyltransferase ii HP433_RS00425 ENOG4108SEH involved in lipopolysaccharide biosynthesis HP433_RS00430 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HP433_RS00440 ENOG4105K64 Glycosyl transferase, family 2 HP433_RS00445 ENOG4105PXI polysaccharide deacetylase HP433_RS00450 ENOG41063SB peptidase HP433_RS00460 ENOG4107YZP Rhodanese domain protein HP433_RS00465 ENOG4105VW4 glutaredoxin 3 HP433_RS00480 ENOG4105D7W serine acetyltransferase HP433_RS00485 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HP433_RS00495 ENOG41073TP transcriptional regulator HP433_RS00500 ENOG4105DAA L-lactate HP433_RS00505 ENOG4105EUR Domain-Containing protein HP433_RS00510 ENOG4108WY4 inner membrane lipoprotein HP433_RS00515 ENOG4108YYI Protein of unknown function (DUF2810) HP433_RS00525 ENOG4105E61 Mannitol repressor protein HP433_RS00535 ENOG4105CTS PTS system mannitol-specific HP433_RS00540 ENOG4105FP6 Protein of unknown function (DUF3302) HP433_RS00545 ENOG4105EFX secretion protein, HlyD family HP433_RS00560 ENOG4105CNA YD repeat protein HP433_RS00565 ENOG4108U78 Glutathione S-transferase HP433_RS00575 ENOG4105EM7 Selenocysteine-specific translation elongation factor HP433_RS00580 ENOG4105C0A alcohol dehydrogenase HP433_RS00585 ENOG4105C26 Dehydrogenase HP433_RS00595 ENOG4105KK7 inner membrane protein YiaW HP433_RS00600 ENOG4105EFX secretion protein, HlyD family HP433_RS00605 ENOG4108Q2M Transcriptional regulator HP433_RS00610 ENOG4105GNX MltA-interacting MipA family protein HP433_RS00620 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HP433_RS00625 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HP433_RS00630 ENOG4105H6Q decarboxylase HP433_RS00635 ENOG4105CMG Carbohydrate kinase HP433_RS00640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HP433_RS00645 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HP433_RS00650 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HP433_RS00655 ENOG4108R66 Conserved Protein HP433_RS00665 ENOG4105J4Q Transcriptional regulator HP433_RS00670 ENOG4108XIB electron transport protein ysaA HP433_RS00675 ENOG4105JKW Valine--pyruvate aminotransferase HP433_RS00680 ENOG4107T9C Alpha amylase catalytic region HP433_RS00685 ENOG4108UR8 BAX protein HP433_RS00690 ENOG4105T16 Transcriptional regulator (AraC family) HP433_RS00695 ENOG4108HWW ABC transporter HP433_RS00700 ENOG4105C2J ABC transporter HP433_RS00705 ENOG4105DFW ABC transporter HP433_RS00715 ENOG4105CMG Carbohydrate kinase HP433_RS00720 ENOG410688U Inner membrane protein yiaB HP433_RS00725 ENOG4108Z12 YiaAB two helix domain-containing protein HP433_RS00730 ENOG4105MEV Acyl-transferase HP433_RS00750 ENOG41060TC Hok gef cell toxic protein HP433_RS00760 ENOG4105MVF Transcriptional regulator HP433_RS00765 ENOG4106JH6 (LipO)protein HP433_RS00775 ENOG4108ZG0 Ompa motb domain protein HP433_RS00780 ENOG4107QY8 reductase HP433_RS00785 ENOG4105HNP -acetyltransferase HP433_RS00790 ENOG4108R3E Dna-3-methyladenine glycosylase i HP433_RS00795 ENOG4105EAX Putative lipase HP433_RS00800 ENOG4105FCD Major Facilitator HP433_RS00805 ENOG4106EAR Fimbrial protein HP433_RS00810 ENOG4108VCD Chaperone HP433_RS00815 ENOG4105CW0 outer membrane usher protein HP433_RS00820 ENOG4105MHR Fimbrial protein HP433_RS00825 ENOG4106UCC Fimbrial protein HP433_RS00830 ENOG4105DIJ Phosphoethanolamine transferase HP433_RS00845 ENOG4105DEF Extracellular solute-binding protein, family 5 HP433_RS00850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP433_RS00855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP433_RS00860 ENOG4105C3U ABC transporter HP433_RS00865 ENOG4108JQ7 (ABC) transporter HP433_RS00870 ENOG4105C44 Serine transporter HP433_RS00890 ENOG4105D1V cellulose synthase operon protein YhjU HP433_RS00895 ENOG4105WQA Cellulose biosynthesis protein BcsF HP433_RS00900 ENOG4105U74 cellulose biosynthesis protein BcsE HP433_RS00905 ENOG410661M cytoplasmic protein HP433_RS00920 ENOG4107EEX Cellulose synthase regulator protein HP433_RS00925 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HP433_RS00930 ENOG4105EJG cellulose synthase HP433_RS00935 ENOG4105BZU Histidine kinase HP433_RS00945 ENOG4105CS0 peptidase HP433_RS00955 ENOG4105CMB EAL domain-containing protein HP433_RS00960 ENOG41066T0 asmA family HP433_RS00965 ENOG4105CSH Transporter HP433_RS00970 ENOG4107H3J ribonuclease HP433_RS00975 ENOG4105CBN LysR family transcriptional regulator HP433_RS00980 ENOG4106S2D Transcriptional regulator HP433_RS00990 ENOG4105CA0 peroxidase HP433_RS00995 ENOG4105CVK Glutamate decarboxylase HP433_RS01000 ENOG4108NKV transcriptional regulator HP433_RS01010 ENOG4105BZS acriflavin resistance protein HP433_RS01015 ENOG4105C1P efflux transporter, rnd family, mfp subunit HP433_RS01025 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HP433_RS01030 ENOG4108YK4 Acid-resistance membrane protein HP433_RS01035 ENOG41060V2 Acid-resistance protein HP433_RS01040 ENOG4105XXV Acid-resistance protein HP433_RS01045 ENOG4105KT7 mgtC SapB transporter HP433_RS01055 ENOG4105Y4Z Outer Membrane Lipoprotein HP433_RS01075 ENOG4105K89 arsenate reductase HP433_RS01080 ENOG4107R5R arsenical pump membrane protein HP433_RS01085 ENOG4105KBH arsR family transcriptional regulator HP433_RS01095 ENOG4105DC8 reductase HP433_RS01100 ENOG4105D6S protein involved in catabolism of external DNA HP433_RS01105 ENOG4105DGW oligopeptidase A HP433_RS01115 ENOG4105DUX Transporter HP433_RS01130 ENOG4105CJ3 phosphate transporter HP433_RS01135 ENOG4105CBX hi0933 family HP433_RS01205 ENOG410624V efflux system protein HP433_RS01235 ENOG4105DR5 peptidase HP433_RS01245 ENOG4105E3B Multicopper oxidase HP433_RS01250 ENOG4105VR0 copper resistance HP433_RS01255 ENOG4105JDN Copper resistance protein HP433_RS01260 ENOG4108PG2 copper resistance HP433_RS01265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP433_RS01270 ENOG4105GR3 Histidine kinase HP433_RS01280 ENOG4107UNS conserved inner membrane protein HP433_RS01295 ENOG4105D0S secretion protein (HlyD HP433_RS01300 ENOG4105CJ1 ABC, transporter HP433_RS01305 ENOG4105CMI transporter HP433_RS01330 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HP433_RS01335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP433_RS01340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP433_RS01350 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HP433_RS01355 ENOG4105DSF transport protein HP433_RS01360 ENOG4105F9N Major Facilitator Superfamily HP433_RS01365 ENOG4108W1V Lipoprotein HP433_RS01370 ENOG4105EX9 Membrane HP433_RS01385 ENOG4107FS9 Membrane HP433_RS01395 ENOG4105MG3 Membrane HP433_RS01400 ENOG4106H78 methyltransferase HP433_RS01405 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HP433_RS01410 ENOG4105CAK Cell division ATP-binding protein ftsE HP433_RS01415 ENOG4105CRP Part of the ABC transporter FtsEX involved in HP433_RS01420 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP433_RS01425 ENOG4105CP9 extracellular ligand-binding receptor HP433_RS01430 ENOG4105U59 -acetyltransferase HP433_RS01435 ENOG4105CP9 extracellular ligand-binding receptor HP433_RS01440 ENOG4105C32 Amino acid ABC transporter (Permease) HP433_RS01445 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HP433_RS01450 ENOG4105C0Z ABC transporter HP433_RS01455 ENOG4108IV0 ABC, transporter HP433_RS01460 ENOG4105BZ7 extracellular solute-binding protein family 1 HP433_RS01465 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HP433_RS01470 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HP433_RS01480 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HP433_RS01485 ENOG4105WC8 Conserved Protein HP433_RS01490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HP433_RS01495 ENOG4106FA4 HP433_RS01510 ENOG4105GMB type VI secretion system effector, hcp1 family HP433_RS01515 ENOG4105WCN acetyltransferase HP433_RS01520 ENOG4105D9R oxidoreductase HP433_RS01525 ENOG4105C2I pirin domain protein HP433_RS01530 ENOG4105DIQ Transcriptional regulator HP433_RS01535 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HP433_RS01540 ENOG4105C6Z Gluconate HP433_RS01545 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HP433_RS01550 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HP433_RS01560 ENOG4108IUM Glycogen debranching enzyme HP433_RS01575 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HP433_RS01600 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HP433_RS01615 ENOG4105E98 transcriptional regulator DeoR family HP433_RS01620 ENOG4105CYB regulatoR HP433_RS01625 ENOG4105E0Y RtcB Protein HP433_RS01640 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HP433_RS01645 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HP433_RS01650 ENOG4105C6Z Gluconate HP433_RS01665 ENOG4105MJ2 Competence protein HP433_RS01685 ENOG4105CE1 Ferrous iron transport protein b HP433_RS01690 ENOG4105XFK Ferrous iron transport protein A HP433_RS01695 ENOG4105BZM domain protein HP433_RS01700 ENOG4108RRZ Transcription elongation factor GreB HP433_RS01710 ENOG4105E0F Histidine kinase HP433_RS01720 ENOG4108MAJ Membrane HP433_RS01730 ENOG4105VEJ Heat shock protein HP433_RS01735 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HP433_RS01740 ENOG4105DQY intracellular growth attenuator HP433_RS01745 ENOG4107RK2 ADP-ribose diphosphatase NudE HP433_RS01750 ENOG4108JQC penicillin-binding protein 1A HP433_RS01755 ENOG4108U1Q Pilus assembly protein HP433_RS01760 ENOG41065NF Fimbrial assembly family protein HP433_RS01765 ENOG4105XPX DNA utilization protein HofO HP433_RS01770 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HP433_RS01775 ENOG4105E4G Type IV pilus HP433_RS01790 ENOG4105EGB membrane protein DamX HP433_RS01795 ENOG4105DFE Dna adenine methylase HP433_RS01800 ENOG4105DJV ribulose-phosphate 3-epimerase HP433_RS01805 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HP433_RS01810 ENOG4105C31 Tryptophanyl-tRNA synthetase HP433_RS01815 ENOG4108M21 HP433_RS01820 ENOG4105RMW regulation of transcription, DNA-dependent HP433_RS01825 ENOG4108626 Racemase HP433_RS01830 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HP433_RS01835 ENOG41080QX K07048 phosphotriesterase-related protein HP433_RS01840 ENOG4105MUZ Protein of unknown function DUF2620 HP433_RS01845 ENOG4106M0N transport system permease protein HP433_RS01850 ENOG4106PKC pyridoxal phosphate binding HP433_RS01855 ENOG4105VYH HP433_RS01865 ENOG4107V9H nitrite transporter HP433_RS01870 ENOG4105WZK nitrite reductase NADPH small subunit HP433_RS01875 ENOG4107QZF nitrite reductase NADPH large subunit HP433_RS01885 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HP433_RS01895 ENOG4105MZU cell filamentation protein HP433_RS01900 ENOG4105DDQ anthranilate synthase HP433_RS01905 ENOG4105C8Y Acetylornithine aminotransferase HP433_RS01910 ENOG410613R integral membrane protein, YccS YhfK family HP433_RS01920 ENOG4108UKZ OsmC family HP433_RS01925 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HP433_RS01935 ENOG4105DNZ Alpha Beta Hydrolase HP433_RS01940 ENOG4105C5H ABC transporter HP433_RS01955 ENOG4105VKU nucleicacid-binding protein HP433_RS01960 ENOG4108YZY peptidylprolyl cis-trans isomerase HP433_RS01970 ENOG4108V1T peptidylprolyl cis-trans isomerase HP433_RS01975 ENOG4105WWK YheO domain protein HP433_RS02015 ENOG4105W53 bacterioferritin-associated ferredoxin HP433_RS02020 ENOG4108UQY Iron-storage protein HP433_RS02045 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HP433_RS02090 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HP433_RS02135 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HP433_RS02140 ENOG41067V7 50S ribosomal protein L36 HP433_RS02170 ENOG4105VTS DnaJ-like, subfamily C HP433_RS02175 ENOG4105W1Y Transcriptional regulator HP433_RS02180 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HP433_RS02190 ENOG4105C1A potassium transporter peripheral membrane HP433_RS02210 ENOG4105C79 DNA protecting protein DprA HP433_RS02220 ENOG4108WI1 Dna topoisomerase HP433_RS02235 ENOG4105SG3 Protein of unknown function (DUF1488) HP433_RS02240 ENOG4108Z0R Transferase HP433_RS02280 ENOG4105CDA abc transporter atp-binding protein HP433_RS02285 ENOG4105DRP amino acid AbC transporter HP433_RS02290 ENOG4105EZ7 amino acid ABC transporter HP433_RS02300 ENOG4105XCM membrane LIPOPROTEIN HP433_RS02305 ENOG4105BZS acriflavin resistance protein HP433_RS02310 ENOG4105C1P efflux transporter, rnd family, mfp subunit HP433_RS02315 ENOG4108XG4 DNA-binding transcriptional regulator HP433_RS02320 ENOG41061ME transport protein HP433_RS02325 ENOG4105CEC DNA methylase N-4 N-6 HP433_RS02335 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HP433_RS02345 ENOG4108IA2 Sodium pantothenate symporter HP433_RS02350 ENOG4105RG0 Membrane HP433_RS02355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HP433_RS02360 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HP433_RS02365 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HP433_RS02370 ENOG41062P1 Diguanylate cyclase phosphodiesterase HP433_RS02380 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HP433_RS02385 ENOG4105VQ7 Rod shape-determining protein MreD HP433_RS02395 ENOG4105C03 ribonuclease HP433_RS02400 ENOG4105QD6 exported protein HP433_RS02405 ENOG4105D1U peptidase U62 modulator of DNA gyrase HP433_RS02410 ENOG4105CR8 Transcriptional regulator HP433_RS02415 ENOG4105ZQC membrane protein AaeX HP433_RS02430 ENOG4105UNR (Barnase) inhibitor HP433_RS02435 ENOG4105RID UPF0379 protein yhcN HP433_RS02450 ENOG4105C0H protease HP433_RS02455 ENOG4105C0H protease HP433_RS02460 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HP433_RS02465 ENOG4105D6Z AFG1 family ATPase HP433_RS02480 ENOG4107MKT Stringent starvation protein a HP433_RS02485 ENOG4105KB2 stringent starvation protein b HP433_RS02490 ENOG4105CEE C4-dicarboxylate transporter HP433_RS02505 ENOG4105JHE Major Facilitator Superfamily HP433_RS02520 ENOG4108R66 Conserved Protein HP433_RS02525 ENOG4105DFS Conserved Protein HP433_RS02530 ENOG4105BZ8 glutamate synthase HP433_RS02535 ENOG4105CBC glutamate synthase HP433_RS02540 ENOG4105N5T Radical SAM Protein HP433_RS02545 ENOG4105BZU Histidine kinase HP433_RS02550 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HP433_RS02560 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HP433_RS02565 ENOG41080Z8 PHOSPHOCARRIER protein HP433_RS02575 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HP433_RS02580 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HP433_RS02585 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP433_RS02590 ENOG4108IUZ ABC transporter HP433_RS02595 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HP433_RS02600 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HP433_RS02610 ENOG4105C2X Arabinose 5-phosphate isomerase HP433_RS02615 ENOG4105FEU K -dependent Na -Ca exchanger HP433_RS02620 ENOG4105DHJ ABC, transporter HP433_RS02625 ENOG4105CY3 ABC transporter, permease HP433_RS02630 ENOG4107PE3 Mammalian cell entry related domain protein HP433_RS02635 ENOG4105E3I toluene tolerance HP433_RS02640 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HP433_RS02645 ENOG4105VFK BolA family HP433_RS02655 ENOG4105HVQ Regulatory factor of maltose metabolism HP433_RS02660 ENOG4105EAH synthase HP433_RS02675 ENOG4105QYV Membrane HP433_RS02685 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HP433_RS02690 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HP433_RS02695 ENOG4105HBR Rna-binding protein HP433_RS02705 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HP433_RS02710 ENOG4105EEI dihydropteroate synthase HP433_RS02720 ENOG4105NTZ Preprotein translocase subunit SecG HP433_RS02760 ENOG4105CHV Transcription elongation factor NusA HP433_RS02800 ENOG4105C1J atp-dependent rna helicase HP433_RS02805 ENOG4105CIC tryptophan-specific transport protein HP433_RS02810 ENOG4105DEN Luciferase family HP433_RS02830 ENOG4108YYD acetyltransferase HP433_RS02845 ENOG4107R7Y intracellular protease Pfpi family HP433_RS02850 ENOG4105K4T epimerase HP433_RS02855 ENOG4107S21 permease HP433_RS02860 ENOG4105W4M Transport-associated protein HP433_RS02875 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HP433_RS02880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HP433_RS02885 ENOG4105I74 Fimbrial protein HP433_RS02890 ENOG4105CW0 outer membrane usher protein HP433_RS02895 ENOG4108VCD Chaperone HP433_RS02900 ENOG4105Q10 Fimbrial-like protein HP433_RS02905 ENOG4106HBN Galactosamine-6-phosphate isomerase HP433_RS02910 ENOG4105F3R pts system mannose fructose sorbose family iid HP433_RS02915 ENOG4105ETZ PTS System HP433_RS02920 ENOG4108UZY PTS System HP433_RS02930 ENOG4105E70 isomerase HP433_RS02935 ENOG4105CE4 GlcNAc 6-P deacetylase HP433_RS02940 ENOG4108YTN IIa component HP433_RS02945 ENOG4105F3R pts system mannose fructose sorbose family iid HP433_RS02955 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HP433_RS02965 ENOG4105E98 transcriptional regulator DeoR family HP433_RS02970 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HP433_RS02975 ENOG4105ZEG Suppressor protein HP433_RS02980 ENOG4105CTX dehydratase HP433_RS02985 ENOG4105DJB Major Facilitator Superfamily HP433_RS02995 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HP433_RS03000 ENOG4105BZW Glycerate kinase HP433_RS03030 ENOG410811B TRANSCRIPTIONal HP433_RS03035 ENOG4105C7B Threonine dehydratase HP433_RS03045 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HP433_RS03050 ENOG4105C6N Formate acetyltransferase HP433_RS03055 ENOG4105KME endoribonuclease L-psp HP433_RS03060 ENOG4105EJQ L-serine dehydratase HP433_RS03065 ENOG4105C44 Serine transporter HP433_RS03075 ENOG4106D80 Uncharacterized protein YhaL HP433_RS03080 ENOG4108CNN domain protein HP433_RS03085 ENOG4105CWB LysR family transcriptional Regulator HP433_RS03090 ENOG4105KAF membrAne HP433_RS03095 ENOG4105KAF membrAne HP433_RS03100 ENOG4105CHF Glutathione S-transferase HP433_RS03105 ENOG4108VBZ doxx family HP433_RS03110 ENOG4105YJD HP433_RS03115 ENOG41090KG Inner membrane protein YqjE HP433_RS03120 ENOG4105NE1 Conserved Protein HP433_RS03125 ENOG4105WAY exported protein HP433_RS03130 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HP433_RS03135 ENOG4106W5V Membrane HP433_RS03140 ENOG4107YCY Transcriptional regulator HP433_RS03165 ENOG4105DPW Major facilitator superfamily MFS_1 HP433_RS03175 ENOG4105CTX dehydratase HP433_RS03180 ENOG4105P66 Membrane HP433_RS03185 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HP433_RS03190 ENOG4105DU1 integral membrane protein, terc HP433_RS03195 ENOG4105EE0 oxidoreductase HP433_RS03200 ENOG4108UB4 uncharacterized protein ygjQ HP433_RS03205 ENOG4108VKG metal-dependent hydrolase HP433_RS03215 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HP433_RS03220 ENOG4107WCA isomerase HP433_RS03225 ENOG4107W6W Conserved Protein HP433_RS03230 ENOG4105E5D amino acid HP433_RS03235 ENOG4105FK9 beta-D-galactosidase beta subunit HP433_RS03240 ENOG4105CNT hydrolase family 2 HP433_RS03245 ENOG4105CQ4 Transcriptional regulator HP433_RS03250 ENOG4108Y51 tRNA-binding protein HP433_RS03260 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HP433_RS03265 ENOG4105NTW Transcriptional regulator HP433_RS03270 ENOG4105Q26 Siderophore-interacting protein HP433_RS03295 ENOG4108P8R HP433_RS03300 ENOG4108P8R HP433_RS03315 ENOG4105BZU Histidine kinase HP433_RS03325 ENOG4108TUY outer membrane protein PgaA HP433_RS03330 ENOG4107BJW polysaccharide deacetylase HP433_RS03335 ENOG4105CND Glycosyl transferase, family 2 HP433_RS03345 ENOG4105D5M phosphate starvation-inducible protein HP433_RS03375 ENOG4105C5Y PTS System HP433_RS03390 ENOG4105D7K pfkb domain protein HP433_RS03420 ENOG4105CVR type I restriction-modification system HP433_RS03440 ENOG4105PBD transposase, IS3 IS911 family protein HP433_RS03465 ENOG4105F9F transposase HP433_RS03480 ENOG410607W Transposase HP433_RS03495 ENOG4105F9F transposase HP433_RS03505 ENOG4105F4K antigen 43 HP433_RS03510 ENOG4106H6R UPF0380 protein HP433_RS03515 ENOG4105MFG Antirestriction protein HP433_RS03520 ENOG4108YGG dna repair protein HP433_RS03530 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HP433_RS03565 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP433_RS03570 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HP433_RS03585 ENOG4107QPK )-transporter HP433_RS03590 ENOG4107GFK fumarate HP433_RS03595 ENOG4106DSS Tartrate dehydratase subunit alpha HP433_RS03600 ENOG4105EJC lysr family transcriptional regulator HP433_RS03610 ENOG4107ZVW dihydroneopterin aldolase HP433_RS03625 ENOG4106MWK domain protein HP433_RS03630 ENOG4105I7R Adenylate cyclase HP433_RS03655 ENOG4107S78 Band 7 protein HP433_RS03660 ENOG4105PV3 Inner membrane protein yqiJ HP433_RS03670 ENOG4108MY7 Fimbrial HP433_RS03675 ENOG4108TTM chaperone HP433_RS03685 ENOG4105H8W Fimbrial protein HP433_RS03690 ENOG4105W0Z cytoplasmic protein HP433_RS03710 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HP433_RS03715 ENOG4106032 Glutathionylspermidine synthase HP433_RS03725 ENOG4105DFG type I secretion outer membrane protein HP433_RS03730 ENOG41087AY ADP-Ribose pyrophosphatase HP433_RS03735 ENOG4108SX3 cytoplasmic protein HP433_RS03740 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HP433_RS03745 ENOG4105IPS esterase HP433_RS03750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP433_RS03755 ENOG4105VRH Antibiotic biosynthesis monooxygenase HP433_RS03760 ENOG4105NF4 modulator of drug activity HP433_RS03765 ENOG4107DEU Inner membrane protein YgiZ HP433_RS03770 ENOG4105DHQ Histidine kinase HP433_RS03775 ENOG4105XJC Two component transcriptional regulator (Winged helix family HP433_RS03780 ENOG4105H4F exported protein HP433_RS03785 ENOG4105F4I Transcriptional regulator HP433_RS03790 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP433_RS03795 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HP433_RS03800 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HP433_RS03805 ENOG4105CCT upf0313 protein HP433_RS03815 ENOG4105ZKC Conserved Protein HP433_RS03820 ENOG4105CV8 reductase HP433_RS03825 ENOG4108I6A alcohol dehydrogenase HP433_RS03830 ENOG4105CF7 AraC family transcriptional regulator HP433_RS03835 ENOG4108K81 inner membrane protein YghB HP433_RS03840 ENOG4105C28 cystathionine HP433_RS03845 ENOG4105CWK Biopolymer transport protein, ExbB HP433_RS03850 ENOG4108ZZF transport protein (ExbD) HP433_RS03860 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HP433_RS03870 ENOG4105CPC Aldo Keto reductase HP433_RS03880 ENOG410900S Protein of unknown function (DUF2623) HP433_RS03885 ENOG4105E3S small subunit HP433_RS03890 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP433_RS03895 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HP433_RS03900 ENOG4105DPX Hydrogenase, large subunit HP433_RS03905 ENOG4108USZ hydrogenase HP433_RS03910 ENOG4108WGS hydrogenase 2-specific chaperone HP433_RS03915 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HP433_RS03920 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HP433_RS03925 ENOG4105CYM Glutathione S-transferase HP433_RS03930 ENOG4106032 Glutathionylspermidine synthase HP433_RS03935 ENOG4105CJ3 phosphate transporter HP433_RS03940 ENOG4108GH0 ATP-binding protein yghT HP433_RS03945 ENOG4108NDC ATP-binding protein yghS HP433_RS03950 ENOG4106FPV ATP-binding protein YghR HP433_RS03955 ENOG4108S55 polysaccharide biosynthesis protein HP433_RS03965 ENOG4108UUE Transcriptional regulator HP433_RS03970 ENOG4108M8S permease YjgP YjgQ family protein HP433_RS03980 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HP433_RS03985 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HP433_RS03995 ENOG4107RCI amp-dependent synthetase and ligase HP433_RS04005 ENOG4108KWP DNA-binding transcriptional regulator GlcC HP433_RS04010 ENOG4105CQB FAD linked oxidase domain protein HP433_RS04015 ENOG4105EU8 FAD linked oxidase domain protein HP433_RS04020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HP433_RS04025 ENOG4108ZJF Glcg protein HP433_RS04030 ENOG4107QP3 malate synthase g HP433_RS04035 ENOG4105DAA L-lactate HP433_RS04055 ENOG4108UQV Membrane HP433_RS04060 ENOG4105CXN decarboxylase HP433_RS04065 ENOG4105EAA nucleoside HP433_RS04080 ENOG4105CEN a g-specific adenine glycosylase HP433_RS04090 ENOG41090ED Protein with unknown function (DUF469) HP433_RS04095 ENOG4105K33 Periplasmic Protein HP433_RS04100 ENOG4105HDK L-asparaginase HP433_RS04105 ENOG4106MH3 alpha helix chain HP433_RS04110 ENOG4105CSA Coproporphyrinogen iii oxidase HP433_RS04115 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HP433_RS04125 ENOG4108VIA integral membrane protein HP433_RS04130 ENOG4105DFA alanine racemase domain protein HP433_RS04135 ENOG4105CZX twitching motility protein HP433_RS04150 ENOG4105D7Z glutathione synthase HP433_RS04155 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HP433_RS04160 ENOG4105RWS endonuclease I HP433_RS04170 ENOG4107QNK )-transporter HP433_RS04190 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HP433_RS04215 ENOG4105DAS pts system HP433_RS04220 ENOG4105ETZ PTS System HP433_RS04225 ENOG4105F3R pts system mannose fructose sorbose family iid HP433_RS04240 ENOG4108K0D peptidase, M48 HP433_RS04245 ENOG4105CV1 Transketolase (EC 2.2.1.1) HP433_RS04250 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HP433_RS04255 ENOG4105CTS PTS system mannitol-specific HP433_RS04260 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HP433_RS04265 ENOG4108Q8A Fructose-1,6-bisphosphatase HP433_RS04270 ENOG4108R4K DNA-binding, transcriptional regulator HP433_RS04275 ENOG4107Z1W Fructose transport system kinase HP433_RS04280 ENOG4108JJB ABC transporter HP433_RS04285 ENOG4108JJB ABC transporter HP433_RS04315 ENOG4105D2N Aldolase HP433_RS04320 ENOG4105D64 Mechanosensitive ion channel HP433_RS04325 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HP433_RS04330 ENOG4105MPN Membrane HP433_RS04335 ENOG4105DEQ transcriptional regulator HP433_RS04340 ENOG4105CYC Transferase HP433_RS04345 ENOG4108M7F enoyl-CoA hydratase isomerase HP433_RS04350 ENOG4105DJT lAO AO transport system ATPase HP433_RS04355 ENOG4105D5P Methylmalonyl-coA mutase HP433_RS04375 ENOG4108JQ1 Dehydrogenase HP433_RS04390 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HP433_RS04410 ENOG4107RAQ aminopeptidase HP433_RS04415 ENOG4105D0A hydroxylase HP433_RS04420 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HP433_RS04445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HP433_RS04450 ENOG4105CS2 ec 3.2.1.21 HP433_RS04460 ENOG4108UT2 hemolysin iii HP433_RS04470 ENOG4105Y75 tpr repeat protein HP433_RS04475 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HP433_RS04480 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HP433_RS04485 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HP433_RS04490 ENOG4105T95 Thiol disulfide interChange protein HP433_RS04495 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HP433_RS04525 ENOG4105C2W permease HP433_RS04530 ENOG4105BZ8 glutamate synthase HP433_RS04535 ENOG4108R8B oxidoreductase Fe-S subunit HP433_RS04540 ENOG4105C7N Xanthine uracil vitamin C permease HP433_RS04545 ENOG4107QUY Guanine deaminase HP433_RS04550 ENOG4105C2W permease HP433_RS04555 ENOG4105C7W Xanthine dehydrogenase HP433_RS04560 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HP433_RS04565 ENOG4107UUR Chlorohydrolase aminohydrolase HP433_RS04570 ENOG4105BZ8 glutamate synthase HP433_RS04575 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HP433_RS04580 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HP433_RS04585 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HP433_RS04590 ENOG4105C5B carbamate kinase HP433_RS04600 ENOG4107S4Y M20 DapE family protein YgeY HP433_RS04605 ENOG4107RCH Diaminopropionate ammonia-lyase HP433_RS04610 ENOG4105IW6 Carbamoyltransferase HP433_RS04615 ENOG4108JUB Transcriptional regulator HP433_RS04620 ENOG4108UTP (2Fe-2S)-binding domain protein HP433_RS04625 ENOG4108HR6 Dehydrogenase HP433_RS04630 ENOG4105C7W Xanthine dehydrogenase HP433_RS04635 ENOG4108K5P (LipO)protein HP433_RS04645 ENOG4108T88 HP433_RS04655 ENOG41075IY surface presentation of antigens protein SpaP HP433_RS04665 ENOG4108TN6 type iii secretion HP433_RS04670 ENOG4108M6W surface presentation of antigens protein SpaS HP433_RS04675 ENOG4108M6W surface presentation of antigens protein SpaS HP433_RS04690 ENOG4108RC9 Type III secretion system protein HP433_RS04705 ENOG4108RBT type iii secretion HP433_RS04735 ENOG4108YAB Invasion protein HP433_RS04760 ENOG4105FV3 HP433_RS04765 ENOG4108TC1 Transcriptional regulator HP433_RS04770 ENOG4105ISV protein with bipartite regulator domain HP433_RS04775 ENOG4108MHD transport protein HP433_RS04780 ENOG4105CHU acetyl-coa acetyltransferase HP433_RS04790 ENOG4105CHR reductase HP433_RS04795 ENOG4107QNK )-transporter HP433_RS04805 ENOG4105RQF LysR family Transcriptional regulator HP433_RS04815 ENOG41060NJ transcriptional regulator HP433_RS04825 ENOG4107S74 Lysophospholipid transporter LplT HP433_RS04830 ENOG4105CPC Aldo Keto reductase HP433_RS04835 ENOG4105SUV lipoprotein YgdR HP433_RS04840 ENOG4105EE5 Membrane protein terC HP433_RS04855 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HP433_RS04870 ENOG4105IPU prepilin peptidase dependent protein A HP433_RS04875 ENOG4105JCS prepilin peptidase dependent protein HP433_RS04880 ENOG4105SEN Protein of unknown function (DUF2509) HP433_RS04885 ENOG4105RVB Prepilin peptidase dependent protein c HP433_RS04890 ENOG4105DSY exodeoxyribonuclease V, gamma HP433_RS04895 ENOG4107QXK peptidase HP433_RS04900 ENOG4107QKA exodeoxyribonuclease V beta HP433_RS04905 ENOG4107QYX exodeoxyribonuclease v alpha HP433_RS04910 ENOG4108EKC n-acetylglutamate synthase HP433_RS04915 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HP433_RS04935 ENOG4105CA3 membrane-bound lytic murein transglycosylase HP433_RS04940 ENOG4105CUZ uba thif-type nad fad binding protein HP433_RS04945 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HP433_RS04950 ENOG4105C9B Cysteine desulfurase HP433_RS04955 ENOG4105M5B (LipO)protein HP433_RS04960 ENOG4105ETT transcriptional Regulator, LysR family HP433_RS04965 ENOG4105M08 Membrane HP433_RS04975 ENOG4107EDW L-fucose operon activator HP433_RS04985 ENOG4105CMG Carbohydrate kinase HP433_RS04995 ENOG4105EDR glucose galactose transporter HP433_RS05000 ENOG4107W7X Aldolase HP433_RS05005 ENOG4105C0A alcohol dehydrogenase HP433_RS05015 ENOG4105EJQ L-serine dehydratase HP433_RS05020 ENOG4105C44 Serine transporter HP433_RS05025 ENOG4105EWT decarboxylase family HP433_RS05040 ENOG4105WP7 tRNA pseudouridine synthase C HP433_RS05045 ENOG4105DR9 pseudouridine synthase HP433_RS05050 ENOG4105QDK Flavodoxin HP433_RS05055 ENOG4105DJB Major Facilitator Superfamily HP433_RS05060 ENOG4105EQX glucarate dehydratase HP433_RS05065 ENOG4105EQX glucarate dehydratase HP433_RS05070 ENOG4105BZU Histidine kinase HP433_RS05080 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HP433_RS05085 ENOG4106A2Z transcriptional regulator antitoxin, MazE HP433_RS05090 ENOG4105MZG transcriptional modulator of maze toxin, mazf HP433_RS05095 ENOG4105DXN mazG family HP433_RS05110 ENOG4105HA9 of methanol dehydrogenase type HP433_RS05120 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HP433_RS05125 ENOG4108CWB sugar kinase ygcE HP433_RS05130 ENOG4108ITV Inner membrane protein yqcE HP433_RS05135 ENOG4105CHR reductase HP433_RS05140 ENOG4107R3A FAD linked oxidase domain protein HP433_RS05145 ENOG4105C54 Major Facilitator superfamily HP433_RS05150 ENOG4106IKH Electron transfer flavoprotein HP433_RS05155 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HP433_RS05160 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HP433_RS05165 ENOG4105WQV ferredoxin-like protein HP433_RS05170 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HP433_RS05175 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HP433_RS05195 ENOG4107635 Hok Gef family protein HP433_RS05200 ENOG4105DTT CRISPR-associated helicase, cas3 HP433_RS05205 ENOG4105CYR Crispr-associated protein, cse1 family HP433_RS05215 ENOG41060M0 Crispr-associated protein, cse4 family HP433_RS05220 ENOG4108VWQ crispr-associated protein HP433_RS05230 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HP433_RS05235 ENOG4105PWE CRISPR-associated protein cas2 HP433_RS05240 ENOG4108MXK alkaline phosphatase isozyme conversion HP433_RS05260 ENOG4105N0Z inner membrane protein ygbE HP433_RS05295 ENOG4108K5P (LipO)protein HP433_RS05300 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP433_RS05310 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HP433_RS05315 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HP433_RS05320 ENOG4105KZM cytoplasmic protein HP433_RS05325 ENOG4105C6Z Gluconate HP433_RS05330 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HP433_RS05335 ENOG4105FB2 class II Aldolase HP433_RS05340 ENOG4105G63 Type III effector Hrp-dependent HP433_RS05345 ENOG4105ZXK Dehydrogenase HP433_RS05350 ENOG4105MVE transcriptional regulator HP433_RS05355 ENOG4105MEW serine threonine protein phosphatase HP433_RS05370 ENOG4105VXR cytoplasmic protein HP433_RS05375 ENOG4108JUA Transcriptional regulator HP433_RS05380 ENOG4105C45 hydrogenase expression formation protein (HypE) HP433_RS05385 ENOG4105CQS hydrogenase expression formation protein HypD HP433_RS05390 ENOG41083WG hydrogenase assembly chaperone HP433_RS05395 ENOG4107RSS Hydrogenase accessory protein HypB HP433_RS05400 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HP433_RS05405 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HP433_RS05410 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HP433_RS05415 ENOG4107R30 NADH dehydrogenase HP433_RS05420 ENOG4107TDF Formate hydrogenlyase subunit 4 HP433_RS05425 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HP433_RS05430 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HP433_RS05435 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HP433_RS05440 ENOG4105I6X formate hydrogenlyase maturation HP433_RS05445 ENOG4108MG9 hydrogenase 3 maturation protease HP433_RS05450 ENOG4105CS2 ec 3.2.1.21 HP433_RS05455 ENOG4105C5Y PTS System HP433_RS05460 ENOG4105DDV Transcriptional regulator (LacI family HP433_RS05465 ENOG4108RC0 Electron transport protein HP433_RS05470 ENOG4105C8H hydrogenase maturation protein Hypf HP433_RS05495 ENOG410804X Transcriptional regulator HP433_RS05500 ENOG4105J92 DNA-binding transcriptional activator GutM HP433_RS05505 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HP433_RS05510 ENOG4105VI0 Pts system, glucitol sorbitol-specific HP433_RS05515 ENOG4105DZY Pts system, glucitol sorbitol-specific HP433_RS05520 ENOG410787A Pts system, glucitol sorbitol-specific HP433_RS05525 ENOG4105CVE Lytic murein transglycosylase HP433_RS05530 ENOG4107TH8 cina domain protein HP433_RS05550 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HP433_RS05580 ENOG4107VXZ Hydrolase HP433_RS05585 ENOG4105W39 Membrane HP433_RS05600 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP433_RS05605 ENOG4105CW7 secretion protein, HlyD family HP433_RS05610 ENOG4105NTK Transcriptional repressor Mpra HP433_RS05615 ENOG4105ZED uncharacterized protein ygaH HP433_RS05620 ENOG4108UMN azlc family HP433_RS05630 ENOG4105GIJ Glycine betaine HP433_RS05635 ENOG4108HQS Glycine betaine HP433_RS05640 ENOG4108IJ7 Glycine betaine HP433_RS05645 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP433_RS05650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP433_RS05660 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HP433_RS05665 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HP433_RS05670 ENOG4108WMJ Protein of unknown function (DUF2002) HP433_RS05675 ENOG4108RNS Exports L-alanine (By similarity) HP433_RS05680 ENOG4108X73 DNA- binding protein HP433_RS05685 ENOG4108V62 Rhodanese domain protein HP433_RS05690 ENOG41080HT Transcriptional regulator, arsr family HP433_RS05695 ENOG4105VPI YqaE family transport protein HP433_RS05700 ENOG4109066 lysm domain bon superfamily protein HP433_RS05705 ENOG4108PVQ transcriptional regulator HP433_RS05710 ENOG4105C85 amino acid HP433_RS05715 ENOG4108JPW Aminotransferase HP433_RS05720 ENOG4105C26 Dehydrogenase HP433_RS05725 ENOG4105D5U fad dependent oxidoreductase HP433_RS05760 ENOG4105DFP Integrase HP433_RS05775 ENOG4108Z1B Cyclase dehydrase HP433_RS05785 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HP433_RS05790 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HP433_RS05805 ENOG4108JU6 CBS domain protein HP433_RS05810 ENOG4106KVJ cytochrome C assembly protein HP433_RS05815 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HP433_RS05840 ENOG41090EK ompa motb domain protein HP433_RS05845 ENOG4108KHX Diguanylate cyclase HP433_RS05850 ENOG4108WS1 HP433_RS05855 ENOG4105QP9 Protein of unknown function (DUF2799) HP433_RS05860 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HP433_RS05865 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HP433_RS05870 ENOG4105CQC Prephenate dehydratase HP433_RS05880 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HP433_RS05885 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HP433_RS05890 ENOG4105C34 Pseudouridine synthase HP433_RS05895 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HP433_RS05900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HP433_RS05925 ENOG4105CSH Transporter HP433_RS05930 ENOG4105T42 (LipO)protein HP433_RS05935 ENOG4105JIM Phosphatidylserine synthase HP433_RS05940 ENOG4105CD5 CoA-binding domain protein HP433_RS05945 ENOG4106IUH DTW domain containing protein HP433_RS05950 ENOG4105K63 Thioredoxin HP433_RS05955 ENOG4105EIB trna rrna methyltransferase HP433_RS05975 ENOG41090KR LysR family transcriptional Regulator HP433_RS05980 ENOG4105C1J atp-dependent rna helicase HP433_RS05990 ENOG4108IYU L-aspartate oxidase HP433_RS06000 ENOG4105EMN RNA polymerase sigma factor HP433_RS06005 ENOG41069PW sigma-e factor negative regulatory protein HP433_RS06010 ENOG4105VQK sigma E regulatory protein, MucB RseB HP433_RS06015 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HP433_RS06025 ENOG4105C3F Signal peptidase i HP433_RS06045 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HP433_RS06060 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HP433_RS06065 ENOG4106G6Q Transcriptional regulator HP433_RS06070 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HP433_RS06075 ENOG4108Z6B deaminase HP433_RS06085 ENOG4107QIK phosphoribosylformylglycinamidine synthase HP433_RS06090 ENOG4107WP9 Histidine kinase HP433_RS06095 ENOG4108SKK alpha helix protein HP433_RS06100 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HP433_RS06110 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HP433_RS06120 ENOG4108NZE NAGC-like transcriptional regulator HP433_RS06125 ENOG4107HQ7 repeat protein HP433_RS06130 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HP433_RS06135 ENOG4108F37 ATP-binding component of a transport system HP433_RS06140 ENOG4105CNN ABC, transporter HP433_RS06145 ENOG4105CPQ Dehydrogenase HP433_RS06150 ENOG4105CPQ Dehydrogenase HP433_RS06155 ENOG4108ZKT aldose 1-epimerase HP433_RS06160 ENOG4108SB3 DoxX Family HP433_RS06185 ENOG4105FUY alpha subunit HP433_RS06190 ENOG4108W5M transcriptional regulator HP433_RS06195 ENOG4105D8G Major Facilitator superfamily HP433_RS06200 ENOG4108MN2 Stationary phase inducible protein CsiE HP433_RS06205 ENOG4107XM9 (LipO)protein HP433_RS06210 ENOG4105ECY inositol monophosphatase HP433_RS06230 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HP433_RS06250 ENOG4108ZIT Ferredoxin, 2FE-2S HP433_RS06255 ENOG4105WVQ Fe-S assembly protein IscX HP433_RS06265 ENOG4105YYA enhanced serine sensitivity protein SseB HP433_RS06270 ENOG4105KHC sulfurtransferase HP433_RS06275 ENOG4105DN3 alpha-2-macroglobulin domain protein HP433_RS06280 ENOG4108JQB penicillin-binding protein 1C HP433_RS06310 ENOG4105N21 Membrane HP433_RS06325 ENOG4105VPD cellular component movement HP433_RS06335 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HP433_RS06345 ENOG41066DY Membrane HP433_RS06350 ENOG4108ZMA Outer membrane lipoprotein HP433_RS06355 ENOG41062G3 Protein of unknown function (DUF2633) HP433_RS06365 ENOG4105BZU Histidine kinase HP433_RS06370 ENOG4105C9X ppx gppa phosphatase HP433_RS06375 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HP433_RS06380 ENOG4108V3E phosphoribosylglycinamide formyltransferase HP433_RS06395 ENOG4105C2W permease HP433_RS06400 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HP433_RS06405 ENOG4105K89 arsenate reductase HP433_RS06410 ENOG4105ERG peptidase m48, ste24p HP433_RS06415 ENOG4105C02 permease HP433_RS06420 ENOG4105TMB Formate nitrite transporter HP433_RS06425 ENOG4105TMB Formate nitrite transporter HP433_RS06430 ENOG4108JUA Transcriptional regulator HP433_RS06435 ENOG4105I6X formate hydrogenlyase maturation HP433_RS06440 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HP433_RS06450 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HP433_RS06460 ENOG4107WQX hydrogenase 4 membrane subunit HP433_RS06470 ENOG4105D65 subunit l HP433_RS06475 ENOG4107TDF Formate hydrogenlyase subunit 4 HP433_RS06485 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HP433_RS06490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HP433_RS06495 ENOG4105RH4 Glycine cleavage system transcriptional repressor HP433_RS06505 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HP433_RS06520 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HP433_RS06525 ENOG4105CGZ zinc metallopeptidase HP433_RS06535 ENOG4106KED esterase YpfH HP433_RS06550 ENOG4105KUZ arsenate reductase HP433_RS06560 ENOG4105BZS acriflavin resistance protein HP433_RS06565 ENOG4105BZU Histidine kinase HP433_RS06570 ENOG4105BZ8 glutamate synthase HP433_RS06580 ENOG4108PVD exported protein HP433_RS06585 ENOG4105CV1 Transketolase (EC 2.2.1.1) HP433_RS06590 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP433_RS06595 ENOG4105C6K Malic enzyme HP433_RS06600 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HP433_RS06605 ENOG4106S4J ethanolamine utilization protein EutP HP433_RS06610 ENOG4105NDK ethanolamine utilization protein HP433_RS06615 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HP433_RS06620 ENOG4107WUY phosphate acetyltransferase HP433_RS06625 ENOG4105KNY Microcompartments protein HP433_RS06630 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HP433_RS06635 ENOG4108EKI Dehydrogenase HP433_RS06640 ENOG4107RWI ethanolamine utilization protein eutJ HP433_RS06645 ENOG4105C0A alcohol dehydrogenase HP433_RS06650 ENOG4105ENY Ethanolamine utilization protein eutH HP433_RS06655 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HP433_RS06660 ENOG4105CPD ethanolamine ammonia-lyase HP433_RS06670 ENOG4106D67 ethanolamine utilization protein HP433_RS06675 ENOG4108X49 Ethanolamine utilization protein EutK HP433_RS06680 ENOG4108K3Z AraC family transcriptional regulator HP433_RS06690 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HP433_RS06700 ENOG4105QZU Inner membrane protein YfeZ HP433_RS06705 ENOG4105E7K (LipO)protein HP433_RS06710 ENOG4105EZR dyp-type peroxidase family protein HP433_RS06715 ENOG4107S1E Beta-lactamase HP433_RS06720 ENOG4105C5Y PTS System HP433_RS06735 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HP433_RS06740 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HP433_RS06745 ENOG4108I5D sulfate abc transporter HP433_RS06750 ENOG4105ECW sulfate abc transporter HP433_RS06755 ENOG4108IJ6 ABC transporter HP433_RS06760 ENOG4105C6T cysteine synthase HP433_RS06765 ENOG4105M0Y HP433_RS06775 ENOG4105C5Y PTS System HP433_RS06780 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HP433_RS06790 ENOG4105C6T cysteine synthase HP433_RS06810 ENOG4105VRT cytoplasmic protein HP433_RS06815 ENOG4105DHU Bile acid HP433_RS06820 ENOG4108M0I Transcriptional regulator HP433_RS06825 ENOG4108NFH Sugar hydrolase HP433_RS06830 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HP433_RS06835 ENOG4105EAA nucleoside HP433_RS06845 ENOG4105CN8 Transcriptional regulator HP433_RS06880 ENOG4105GXM Putative transcription regulator (DUF1323) HP433_RS06885 ENOG4105HZG regulatoR HP433_RS06900 ENOG4108KMM Diguanylate cyclase HP433_RS06905 ENOG4105D9N nucleoside HP433_RS06915 ENOG4109076 Conserved Protein HP433_RS06930 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HP433_RS06935 ENOG410863U PTS System HP433_RS06940 ENOG4105DC7 peptidase M24 HP433_RS06945 ENOG4105CN9 Peptidase m42 family protein HP433_RS06950 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HP433_RS06955 ENOG4108CIP transcriptional regulator HP433_RS06960 ENOG4105DY9 regulatoR HP433_RS06965 ENOG4108HRK Histidine kinase HP433_RS06970 ENOG4105CHM Aminotransferase HP433_RS06980 ENOG4105D1S lipid A biosynthesis HP433_RS06985 ENOG4105W9M Membrane HP433_RS06995 ENOG4108V08 YfdX protein HP433_RS07005 ENOG4105CFN oxalyl-CoA decarboxylase HP433_RS07010 ENOG4108N2Y auxin Efflux HP433_RS07015 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HP433_RS07020 ENOG4105BZU Histidine kinase HP433_RS07025 ENOG4108WQH regulatoR HP433_RS07030 ENOG4105CW7 secretion protein, HlyD family HP433_RS07035 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP433_RS07040 ENOG4105BZC d-serine deaminase HP433_RS07050 ENOG4106NDP Transcriptional regulator HP433_RS07055 ENOG4108HKT sucrose-6-phosphate hydrolase HP433_RS07060 ENOG4105D7K pfkb domain protein HP433_RS07065 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HP433_RS07075 ENOG4108YX2 DNA-binding protein HP433_RS07260 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA HP433_RS07280 ENOG4105FA0 parb-like partition protein HP433_RS07310 ENOG4105KWI UPF0339 protein HP433_RS07335 ENOG4105S64 Formate nitrite transporter HP433_RS07340 ENOG410903C (LipO)protein HP433_RS07350 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HP433_RS07355 ENOG4105KZW UPF0381 protein HP433_RS07370 ENOG4108BY2 phosphohistidine phosphatase HP433_RS07380 ENOG4106PG1 outer membrane usher protein HP433_RS07385 ENOG4108FZ9 Chaperone HP433_RS07390 ENOG4105NEV Fimbrial HP433_RS07395 ENOG4105UGQ Fimbrial HP433_RS07400 ENOG4105US4 fimbrial-like protein yfcP HP433_RS07415 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HP433_RS07420 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HP433_RS07430 ENOG4105EJ9 Membrane HP433_RS07435 ENOG4108BPE -transporting atpase HP433_RS07440 ENOG4105MH2 YfcL protein HP433_RS07450 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HP433_RS07455 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HP433_RS07460 ENOG4105F9N Major Facilitator Superfamily HP433_RS07465 ENOG4106WZ1 flagella biosynthesis regulator HP433_RS07530 ENOG4105UZW Tail fiber assembly protein HP433_RS07535 ENOG4108X9F tail fiber protein HP433_RS07535 ENOG4108X9F tail fiber protein HP433_RS07615 ENOG4105ED4 portal protein HP433_RS07705 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HP433_RS07715 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HP433_RS07725 ENOG4105DQR SNARE associated Golgi HP433_RS07735 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HP433_RS07740 ENOG4108S3P Sporulation domain protein HP433_RS07745 ENOG4105E96 Colicin v production protein HP433_RS07750 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HP433_RS07755 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HP433_RS07760 ENOG4105E89 ABC transporter HP433_RS07765 ENOG4105E89 ABC transporter HP433_RS07770 ENOG4105DSP amino acid AbC transporter HP433_RS07775 ENOG4106YG3 ABC transporter HP433_RS07780 ENOG4108JEH abc transporter atp-binding protein HP433_RS07785 ENOG4105DNE Transposase HP433_RS07790 ENOG4105ECP epimerase HP433_RS07795 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HP433_RS07800 ENOG4105CYM Glutathione S-transferase HP433_RS07805 ENOG4108SHQ Glutathione S-transferase HP433_RS07810 ENOG4108RE9 Phosphodiesterase HP433_RS07815 ENOG4105PTV Nudix Hydrolase HP433_RS07820 ENOG4105CSX c4-dicarboxylate anaerobic carrier HP433_RS07825 ENOG4105C6K Malic enzyme HP433_RS07830 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HP433_RS07840 ENOG4105XWI UPF0304 protein HP433_RS07845 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HP433_RS07850 ENOG4107QWE )-transporter HP433_RS07860 ENOG4105CHM Aminotransferase HP433_RS07865 ENOG4107NQ8 LysR family Transcriptional regulator HP433_RS07885 ENOG4105GKE subunit e HP433_RS07890 ENOG4107QIZ NADH dehydrogenase HP433_RS07895 ENOG4108IEH NADH dehydrogenase subunit g HP433_RS07910 ENOG4107UFS subunit j HP433_RS07920 ENOG4105D65 subunit l HP433_RS07925 ENOG4105C8S subunit m HP433_RS07935 ENOG4105GDX Domain of unknown function (DUF1877) HP433_RS07955 ENOG4107YB6 acetyltransferase, (GNAT) family HP433_RS07960 ENOG4105TNS Conserved Protein HP433_RS07965 ENOG4105E4F Isochorismate synthase HP433_RS07980 ENOG4108IPT Naphthoate synthase HP433_RS07990 ENOG4105CEY Amp-dependent synthetase and ligase HP433_RS07995 ENOG4106GZG polymyxin resistance protein B HP433_RS08045 ENOG4108UII YfaZ family HP433_RS08060 ENOG4105DNE Transposase HP433_RS08065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HP433_RS08075 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HP433_RS08080 ENOG4105CXY transporter HP433_RS08085 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HP433_RS08095 ENOG4105FQR PH-inducible protein involved in stress response HP433_RS08100 ENOG4105XPH Ferredoxin HP433_RS08105 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP433_RS08110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HP433_RS08115 ENOG4107GHC outer membrane autotransporter HP433_RS08125 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HP433_RS08130 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HP433_RS08135 ENOG4108QJJ Protein of unknown function (DUF1175) HP433_RS08140 ENOG4107S52 alpha-2-macroglobulin domain protein HP433_RS08145 ENOG41081SK signal peptide protein HP433_RS08150 ENOG4105EDV vault protein HP433_RS08155 ENOG4105BZU Histidine kinase HP433_RS08160 ENOG41068CG regulatoR HP433_RS08165 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HP433_RS08170 ENOG4105FCK Membrane HP433_RS08175 ENOG4105CJ2 (LipO)protein HP433_RS08180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HP433_RS08185 ENOG4105CF1 Alkylated DNA repair protein HP433_RS08190 ENOG4105IBP Cyclic peptide transporter HP433_RS08205 ENOG4108ZNS ferredoxin-type protein NapF HP433_RS08210 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HP433_RS08220 ENOG4108BGM Quinol dehydrogenase periplasmic component HP433_RS08225 ENOG4105GXZ Ferredoxin-type protein NapH HP433_RS08230 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HP433_RS08235 ENOG4105CUW cytochrome C-TYPE protein HP433_RS08240 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HP433_RS08245 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HP433_RS08250 ENOG41060IM Heme exporter protein HP433_RS08255 ENOG4105X3C heme exporter protein HP433_RS08265 ENOG4105DA4 cytochrome c-type biogenesis protein HP433_RS08270 ENOG4107QX9 Thiol disulfide interChange protein HP433_RS08275 ENOG4105KWW Biogenesis protein HP433_RS08280 ENOG4105WH1 Two component transcriptional regulator luxr family HP433_RS08295 ENOG4105E68 Sulfatase HP433_RS08315 ENOG4105CFI type iii restriction protein res subunit HP433_RS08320 ENOG4105I08 Pseudouridine synthase HP433_RS08325 ENOG4105C2C drug resistance transporter, Bcr CflA HP433_RS08330 ENOG4105HG6 HP433_RS08335 ENOG4108JQ5 ABC transporter HP433_RS08340 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HP433_RS08345 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HP433_RS08350 ENOG4105E43 Extracellular solute-binding protein, family 5 HP433_RS08355 ENOG4105CXC rtn protein HP433_RS08360 ENOG4107TT5 NLP P60 protein HP433_RS08365 ENOG41076MN Phosphoesterase, PA-phosphatase related HP433_RS08370 ENOG4105CKI cobalamin synthesis protein HP433_RS08375 ENOG4105DEI Mannitol dehydrogenase HP433_RS08385 ENOG4105KRS Proteinase inhibitor HP433_RS08390 ENOG4105S8Q sugar efflux transporter HP433_RS08395 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HP433_RS08400 ENOG4105DE4 1-phosphofructokinase HP433_RS08405 ENOG4105DM4 PTS System HP433_RS08410 ENOG4105DD7 kinase (PfkB family HP433_RS08415 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HP433_RS08420 ENOG4105D9N nucleoside HP433_RS08425 ENOG4108Y4K DNA-binding transcriptional activator HP433_RS08435 ENOG4105D9N nucleoside HP433_RS08440 ENOG4105DD7 kinase (PfkB family HP433_RS08450 ENOG4105HMI Membrane HP433_RS08455 ENOG4105DUM transcriptional regulator, lysR family HP433_RS08460 ENOG4108IQI permease HP433_RS08465 ENOG4105D05 Receptor HP433_RS08480 ENOG4105DHF Membrane HP433_RS08485 ENOG41060NJ transcriptional regulator HP433_RS08490 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HP433_RS08495 ENOG4105C2J ABC transporter HP433_RS08500 ENOG4108HWV )-transporter HP433_RS08505 ENOG4107SJI Dehydrogenase HP433_RS08510 ENOG4105BZ8 glutamate synthase HP433_RS08515 ENOG4105Y9N Membrane HP433_RS08520 ENOG4107GZ4 SanA protein HP433_RS08530 ENOG41067MG lrgb family HP433_RS08540 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HP433_RS08550 ENOG4105ETP RND efflux system, outer membrane lipoprotein HP433_RS08560 ENOG4105KHU inner membrane protein YohD HP433_RS08565 ENOG41069YE inner membrane protein yohC HP433_RS08570 ENOG41061WM D-Alanyl-D-Alanine HP433_RS08575 ENOG4105CXG d-lactate dehydrogenase HP433_RS08580 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HP433_RS08585 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HP433_RS08590 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HP433_RS08595 ENOG4108IJ8 ABC transporter HP433_RS08600 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HP433_RS08610 ENOG4108XDN Transcriptional regulator HP433_RS08615 ENOG4108HRK Histidine kinase HP433_RS08620 ENOG4108NEV two component transcriptional regulator, LytTR family HP433_RS08625 ENOG4108W15 Protein of unknown function (DUF1456) HP433_RS08630 ENOG4108YCW (LipO)protein HP433_RS08635 ENOG410903U zinc ion binding HP433_RS08640 ENOG4105DEG Vwa containing coxe family protein HP433_RS08645 ENOG4105RD5 HP433_RS08650 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HP433_RS08660 ENOG4108KDT Molybdate metabolism regulator HP433_RS08665 ENOG4108KDT Molybdate metabolism regulator HP433_RS08675 ENOG4105D1F ATP-binding protein HP433_RS08680 ENOG41067AK Protein of unknown function (DUF2574) HP433_RS08685 ENOG41063W2 Fimbrial protein HP433_RS08690 ENOG4108MQF Chaperone HP433_RS08695 ENOG4105CW0 outer membrane usher protein HP433_RS08700 ENOG410662B Type-1 fimbrial protein HP433_RS08705 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HP433_RS08725 ENOG4105DWF phosphomethylpyrimidine kinase HP433_RS08730 ENOG4108UQ1 hydrolase, family 25 HP433_RS08735 ENOG4105FDP GntR family transcriptional regulator HP433_RS08740 ENOG4108TFM Kinase, PfkB family HP433_RS08745 ENOG4108KD5 ADP-ribosylation crystallin J1 HP433_RS08750 ENOG4105EAA nucleoside HP433_RS08755 ENOG4105EIE fructose-bisphosphate aldolase HP433_RS08770 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HP433_RS08775 ENOG41090UW PTS System HP433_RS08780 ENOG4105DT3 PTS system, galactitol-specific IIc component HP433_RS08785 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HP433_RS08800 ENOG41076Z6 Uncharacterized protein yegR HP433_RS08805 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HP433_RS08865 ENOG4105ED4 portal protein HP433_RS08965 ENOG4105ZTC transcriptional activator, Ogr delta HP433_RS08970 ENOG4105CFP Peptidase U32 HP433_RS08980 ENOG4105X54 addiction module antidote protein HP433_RS08985 ENOG4105KWI UPF0339 protein HP433_RS08990 ENOG4105E3W Two component transcriptional regulator (Winged helix family HP433_RS08995 ENOG4105EB3 Histidine kinase HP433_RS09010 ENOG4105BZS acriflavin resistance protein HP433_RS09035 ENOG4108M24 von Willebrand factor, type A HP433_RS09040 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HP433_RS09045 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HP433_RS09050 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HP433_RS09055 ENOG4105R8A Heat shock protein HP433_RS09060 ENOG4105D03 DNA-3-methyladenine glycosylase II HP433_RS09065 ENOG4105BZU Histidine kinase HP433_RS09070 ENOG4105DBI uridine monophosphokinase HP433_RS09080 ENOG4108GAE asmA family HP433_RS09085 ENOG4105EE5 Membrane protein terC HP433_RS09095 ENOG4105DAY polysaccharide export protein HP433_RS09100 ENOG4105KJF protein tyrosine phosphatase HP433_RS09105 ENOG4105D75 Capsular exopolysaccharide family HP433_RS09110 ENOG41090RK glycosyl transferase HP433_RS09115 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HP433_RS09120 ENOG4107RXY Glycosyl transferase HP433_RS09125 ENOG4108NYJ Colanic acid HP433_RS09130 ENOG4105ECJ Glycosyl Transferase HP433_RS09135 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HP433_RS09140 ENOG4105C0K Gdp-mannose 4,6-dehydratase HP433_RS09145 ENOG4105C30 Nad-dependent epimerase dehydratase HP433_RS09150 ENOG4105FGF GDP-mannose mannosyl hydrolase HP433_RS09155 ENOG4106CD9 glycosyl transferase group 1 HP433_RS09160 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HP433_RS09165 ENOG4107QKV phosphomannomutase HP433_RS09170 ENOG4105D3Q Sugar transferase HP433_RS09175 ENOG4105PSV Polysaccharide Biosynthesis Protein HP433_RS09180 ENOG4105C74 pyruvyl transferase HP433_RS09185 ENOG4107T8Q Glycosyl transferase (Group 1 HP433_RS09190 ENOG4105G1A colanic acid biosynthesis protein HP433_RS09195 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HP433_RS09200 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HP433_RS09205 ENOG4107RZX Teichoic acid biosynthesis protein HP433_RS09210 ENOG4105CG5 Glycosyl transferase (Group 1 HP433_RS09245 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HP433_RS09260 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HP433_RS09285 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HP433_RS09290 ENOG4108RS6 transposase HP433_RS09300 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HP433_RS09310 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HP433_RS09315 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HP433_RS09320 ENOG4105CIH Imidazole acetol-phosphate transaminase HP433_RS09325 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HP433_RS09340 ENOG4105VTW prevent-host-death family HP433_RS09345 ENOG4105KRQ Addiction module toxin, Txe YoeB family HP433_RS09350 ENOG4107SRH Nad-dependent epimerase dehydratase HP433_RS09355 ENOG4105EQ1 Transcriptional regulator HP433_RS09365 ENOG4105CUB amino acid HP433_RS09370 ENOG4105CUC YeeE YedE family protein HP433_RS09380 ENOG4105CJB Exodeoxyribonuclease I HP433_RS09385 ENOG4105DZ1 carboxypeptidase HP433_RS09395 ENOG4105DR8 Membrane HP433_RS09430 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HP433_RS09440 ENOG4108YGG dna repair protein HP433_RS09445 ENOG4105MFG Antirestriction protein HP433_RS09450 ENOG4106H6R UPF0380 protein HP433_RS09465 ENOG4108PZQ Inner membrane protein YeeR HP433_RS09470 ENOG4105F4K antigen 43 HP433_RS09480 ENOG4108P8R HP433_RS09530 ENOG4108YZT Adenosylcobinamide kinase HP433_RS09535 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HP433_RS09540 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HP433_RS09545 ENOG4108PXI ErfK YbiS YcfS YnhG HP433_RS09555 ENOG4106P55 Transcriptional regulator HP433_RS09560 ENOG4107R11 Transcriptional regulator HP433_RS09570 ENOG4105UQX Mate efflux family protein HP433_RS09580 ENOG4105CDY transcriptional regulatory protein HP433_RS09585 ENOG4105FYV Amp nucleosidase HP433_RS09590 ENOG4105CSH Transporter HP433_RS09600 ENOG4105TNG K13735 adhesin invasin HP433_RS09610 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HP433_RS09620 ENOG4108VKM cytochrome b561 HP433_RS09625 ENOG4108MEK Metal-binding protein YodA HP433_RS09640 ENOG4105VT2 5-hydroxyisourate hydrolase HP433_RS09645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP433_RS09650 ENOG4107ZY3 Histidine kinase HP433_RS09655 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) HP433_RS09660 ENOG4105ZIT Porin Gram-negative type HP433_RS09665 ENOG4105Y0K Inner membrane protein YedR HP433_RS09670 ENOG4105EST Metal Dependent Phosphohydrolase HP433_RS09675 ENOG4105DVF Cytosine-specific methyltransferase HP433_RS09680 ENOG41090BB DNA mismatch endonuclease (vsr) HP433_RS09685 ENOG4105FDR Membrane HP433_RS09690 ENOG4105CKW Inner membrane protein yedI HP433_RS09695 ENOG4105VNZ cytoplasmic protein HP433_RS09710 ENOG4105YX3 cellular response to acidity HP433_RS09720 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HP433_RS09725 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HP433_RS09735 ENOG4105CN7 Flagellar biosynthetic protein FliP HP433_RS09740 ENOG4105K0P flagellar biosynthesis protein HP433_RS09745 ENOG4105DD5 Flagellar motor switch protein HP433_RS09750 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HP433_RS09755 ENOG4107ZI8 flagellar basal body-associated protein flil HP433_RS09765 ENOG4105GSA Flagellar export protein flij HP433_RS09770 ENOG4108JIR Flagellum-specific ATP synthase HP433_RS09775 ENOG41090PJ Flagellar assembly protein HP433_RS09780 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HP433_RS09785 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HP433_RS09790 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HP433_RS09795 ENOG410814C multidrug resistance protein HP433_RS09800 ENOG4108V1U phospholipid-binding protein HP433_RS09805 ENOG4108UQN AraC family transcriptional regulator HP433_RS09825 ENOG41066VF YeeE YedE family protein HP433_RS09830 ENOG4108W9D (LipO)protein HP433_RS09835 ENOG4105E5K Alpha-amylase HP433_RS09845 ENOG4105MQ3 flagellar protein FliS HP433_RS09850 ENOG4105DTS flagellar hook-associated HP433_RS09855 ENOG4105I03 Flagellin HP433_RS09860 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HP433_RS09865 ENOG4108M9K flagella biosynthesis protein FliZ HP433_RS09870 ENOG4105EAB amino acid AbC transporter HP433_RS09875 ENOG4105K6H D-cysteine desulfhydrase HP433_RS09880 ENOG4105E5Q amino acid AbC transporter HP433_RS09885 ENOG4105CDA abc transporter atp-binding protein HP433_RS09890 ENOG4105VJY transcriptional regulator HP433_RS09895 ENOG4105XVG cytoplasmic protein HP433_RS09905 ENOG4105WH1 Two component transcriptional regulator luxr family HP433_RS10010 ENOG4107XZC Restriction modification system DNA (Specificity HP433_RS10015 ENOG4106RHG Yeca family HP433_RS10025 ENOG4105DZR Type I site-specific deoxyribonuclease HP433_RS10050 ENOG4105CW0 outer membrane usher protein HP433_RS10055 ENOG4108VCD Chaperone HP433_RS10080 ENOG4106RHG Yeca family HP433_RS10085 ENOG4105E0U tyrosine-specific transport protein HP433_RS10090 ENOG4105VVZ metal-binding protein HP433_RS10095 ENOG41090A1 ferritin HP433_RS10100 ENOG4105P23 (LipO)protein HP433_RS10110 ENOG4105N4N Protein of unknown function (DUF2766) HP433_RS10115 ENOG4108UEC Ferritin-like protein HP433_RS10120 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HP433_RS10140 ENOG4105CNN ABC, transporter HP433_RS10145 ENOG4108K4C ec 3.1.3.12 HP433_RS10155 ENOG4108VA4 Universal stress protein HP433_RS10165 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HP433_RS10170 ENOG4107RD7 Flagellar Motor Protein, MotA HP433_RS10175 ENOG4105ER2 Ompa motb domain protein HP433_RS10180 ENOG4105CBS Chea signal transduction histidine kinase HP433_RS10185 ENOG4108V3W Chemotaxis protein, CheW HP433_RS10190 ENOG4105C8Q Methyl-accepting chemotaxis HP433_RS10195 ENOG4105C8Q Methyl-accepting chemotaxis HP433_RS10200 ENOG4105BZU Histidine kinase HP433_RS10205 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HP433_RS10210 ENOG4108VYJ response regulator receiver protein HP433_RS10215 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HP433_RS10220 ENOG4105D00 flagellar biosynthetic protein flhB HP433_RS10225 ENOG4105D7B Flagellar biosynthesis protein flha HP433_RS10230 ENOG4105W13 flagellar protein HP433_RS10240 ENOG4105C75 arginyL-tRNA synthetase HP433_RS10245 ENOG4106ZCM YecM protein HP433_RS10255 ENOG4105CUW cytochrome C-TYPE protein HP433_RS10260 ENOG4107QY8 reductase HP433_RS10275 ENOG4105WJG Glutathione HP433_RS10280 ENOG41081XQ Conserved Protein HP433_RS10285 ENOG4105D3W isochorismatase HP433_RS10295 ENOG4108TIT dATP pyrophosphohydrolase HP433_RS10300 ENOG4105CDY transcriptional regulatory protein HP433_RS10310 ENOG4107S01 Repressor protein MetJ HP433_RS10330 ENOG4105FAV ABC, transporter HP433_RS10340 ENOG4105NXV High-affinity zinc uptake system protein HP433_RS10345 ENOG4105DR5 peptidase HP433_RS10350 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HP433_RS10355 ENOG4105CA9 Pyruvate kinase HP433_RS10360 ENOG4106KNT transcriptional regulator HP433_RS10365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HP433_RS10370 ENOG4105C01 Dihydroxy-acid dehydratase HP433_RS10375 ENOG4108UHU Aldolase HP433_RS10385 ENOG4105X2V dna damage-inducible protein HP433_RS10395 ENOG4108Q2J Inner membrane protein YebE HP433_RS10400 ENOG4105CUG Oligopeptidase b HP433_RS10405 ENOG4105UMD exodeoxyribonuclease X HP433_RS10410 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HP433_RS10415 ENOG4105MPK DNA polymerase III subunit theta HP433_RS10420 ENOG4105FXM Copper resistance protein HP433_RS10425 ENOG4108PNC copper resistance HP433_RS10430 ENOG4105NKT exported protein HP433_RS10435 ENOG4108R1E Serine threonine protein phosphatase 1 HP433_RS10440 ENOG4105UVW uncharacterized protein yebW HP433_RS10445 ENOG4105WT8 Protein of unknown function (DUF1480) HP433_RS10455 ENOG4105DY2 Paraquat-inducible protein b HP433_RS10460 ENOG4105H2K paraquat-inducible protein a HP433_RS10465 ENOG4108ZGC gaf domain protein HP433_RS10475 ENOG4105CN1 protease HP433_RS10485 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP433_RS10490 ENOG4105J4Q Transcriptional regulator HP433_RS10495 ENOG4105TIK HP433_RS10505 ENOG4105Q3Y exported protein HP433_RS10520 ENOG4105DHI Methyltransferase HP433_RS10535 ENOG4105F3R pts system mannose fructose sorbose family iid HP433_RS10540 ENOG4105ETZ PTS System HP433_RS10545 ENOG4105DAS pts system HP433_RS10550 ENOG4105EE5 Membrane protein terC HP433_RS10555 ENOG4107XTP (EAL) domain protein HP433_RS10560 ENOG4105EJQ L-serine dehydratase HP433_RS10570 ENOG4105CRQ synthase (Component I) HP433_RS10580 ENOG4105V2F Uncharacterized protein yoac HP433_RS10585 ENOG4105M4H endoribonuclease L-psp HP433_RS10590 ENOG4105DVT helicase HP433_RS10595 ENOG41072GX Peptidase M22 Glycoprotease HP433_RS10600 ENOG4105Y4Z Outer Membrane Lipoprotein HP433_RS10605 ENOG4105CEY Amp-dependent synthetase and ligase HP433_RS10610 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HP433_RS10615 ENOG4105E3J oxidoreductase HP433_RS10620 ENOG4105DVW rieske (2Fe-2S) HP433_RS10625 ENOG4105C94 Transporter HP433_RS10630 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HP433_RS10635 ENOG4105EJC lysr family transcriptional regulator HP433_RS10645 ENOG4108YS1 cytoplasmic protein HP433_RS10650 ENOG4105YP6 Domain of unknown function (DUF1869) HP433_RS10660 ENOG4105D7V transposase HP433_RS10665 ENOG4105Y3U Transglycosylase-associated protein HP433_RS10675 ENOG4106G4W HP433_RS10680 ENOG410620I Diguanylate cyclase HP433_RS10685 ENOG4105UCG Domain of unknown function (DUF333) HP433_RS10690 ENOG4105K78 MarR family Transcriptional regulator HP433_RS10695 ENOG4105DJ2 Major Facilitator Superfamily HP433_RS10700 ENOG4105R1U AraC Family Transcriptional Regulator HP433_RS10715 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HP433_RS10720 ENOG4108KHP Diguanylate cyclase HP433_RS10725 ENOG4106KTS Inner membrane protein yeaI HP433_RS10735 ENOG4105CYN Serine protein kinase HP433_RS10740 ENOG4105GNX MltA-interacting MipA family protein HP433_RS10745 ENOG4105CV8 reductase HP433_RS10750 ENOG4105DSB aldose 1-epimerase HP433_RS10755 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HP433_RS10765 ENOG4105VUT cytoplasmic protein HP433_RS10770 ENOG4108RWI nicotinamidase HP433_RS10775 ENOG4105HDK L-asparaginase HP433_RS10780 ENOG4105D07 Signal peptide peptidase, SppA HP433_RS10785 ENOG41069NU Nitroreductase HP433_RS10795 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HP433_RS10800 ENOG41065FB inner membrane protein ynji HP433_RS10805 ENOG4105D82 Glutamate dehydrogenase HP433_RS10810 ENOG4105MTM Protein of unknown function (DUF1496) HP433_RS10815 ENOG4105M6F mutator MutT protein HP433_RS10820 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HP433_RS10825 ENOG4107RM6 sulfurtransferase HP433_RS10830 ENOG4108VGW abc transporter atp-binding protein HP433_RS10835 ENOG4105CXZ ABC transporter, permease HP433_RS10840 ENOG4105VNH ABC transporter solute-binding protein HP433_RS10845 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HP433_RS10850 ENOG4108N5C SNARE associated Golgi protein-related protein HP433_RS10855 ENOG4108KCW iron-sulfur cluster binding HP433_RS10860 ENOG4108RSN SNARE associated Golgi HP433_RS10865 ENOG4105CGK Exodeoxyribonuclease III HP433_RS10895 ENOG4108SPG Periplasmic Protein HP433_RS10905 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HP433_RS10915 ENOG4105KKI DNA-binding transcriptional activator OsmE HP433_RS10920 ENOG4105VZJ PTS System HP433_RS10925 ENOG4105CK1 PTS System HP433_RS10930 ENOG4105VCP PTS System HP433_RS10935 ENOG4105EZV Transcriptional regulator HP433_RS10940 ENOG4105F8D glycoside hydrolase family 4 HP433_RS10950 ENOG4105CH6 catalase HP433_RS10965 ENOG4108ETY sodium dicarboxylate symporter HP433_RS10970 ENOG4107K5X Membrane-bound metal-dependent hydrolase HP433_RS10975 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HP433_RS10980 ENOG4107PN8 YfeABCD locus regulator HP433_RS10990 ENOG4105P10 Uncharacterized protein ydiZ HP433_RS10995 ENOG4105DE4 1-phosphofructokinase HP433_RS11000 ENOG4108NE3 Salt-induced outer membrane protein HP433_RS11020 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HP433_RS11025 ENOG41082NX 50s ribosomal protein l35 HP433_RS11060 ENOG4108V06 Glutathione peroxidase HP433_RS11070 ENOG4108QBX (LipO)protein HP433_RS11075 ENOG4108TC0 Diguanylate phosphodiesterase HP433_RS11090 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HP433_RS11100 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HP433_RS11105 ENOG4105CEY Amp-dependent synthetase and ligase HP433_RS11110 ENOG41090P5 ferredoxin-like protein HP433_RS11115 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HP433_RS11120 ENOG4105C10 Electron transfer flavoprotein HP433_RS11125 ENOG4105CV7 Electron transfer flavoprotein HP433_RS11130 ENOG4105W4W Transcriptional regulator HP433_RS11135 ENOG4105C1G acyl-Coa dehydrogenase HP433_RS11140 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HP433_RS11155 ENOG4105EMV Major Facilitator HP433_RS11160 ENOG4105EMV Major Facilitator HP433_RS11165 ENOG4105SUA Ydil protein HP433_RS11175 ENOG4105IPI Membrane HP433_RS11180 ENOG4105CQB FAD linked oxidase domain protein HP433_RS11185 ENOG4105KA0 thioesterase Superfamily protein HP433_RS11190 ENOG410671Z uncharacterized protein ydiH HP433_RS11195 ENOG4108Z4V iron-sulfur cluster assembly HP433_RS11200 ENOG4105DIW FeS assembly protein SUFB HP433_RS11205 ENOG4105C3K feS assembly ATPase SufC HP433_RS11210 ENOG4105JRK feS assembly protein SufD HP433_RS11225 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HP433_RS11230 ENOG4105KMX major outer membrane lipoprotein HP433_RS11235 ENOG4105CA9 Pyruvate kinase HP433_RS11240 ENOG4105RFR Protein of unknown function (DUF2767) HP433_RS11245 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HP433_RS11250 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HP433_RS11255 ENOG4105JVW HP433_RS11260 ENOG4108393 oxidoreductase Fe-S subunit HP433_RS11265 ENOG4108NWD Cytochrome HP433_RS11270 ENOG4108Y7C Conserved Protein HP433_RS11275 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HP433_RS11280 ENOG4105N0V mono-oxygenase ydhR HP433_RS11305 ENOG4108R6K riboflavin synthase, subunit alpha HP433_RS11310 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HP433_RS11315 ENOG4105CZQ inner membrane transport protein YdhC HP433_RS11320 ENOG4105F52 Transcriptional regulator HP433_RS11335 ENOG4105F27 Major Facilitator HP433_RS11340 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HP433_RS11345 ENOG4105K4H Nlp p60 protein HP433_RS11350 ENOG4105M2J Glutaredoxin HP433_RS11355 ENOG4107QRT dEAD DEAH box helicase HP433_RS11365 ENOG4108UYE Lactoylglutathione lyase HP433_RS11370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HP433_RS11375 ENOG4108WUH Transcriptional regulator, TetR family HP433_RS11380 ENOG4105XZD Fe-S protein HP433_RS11385 ENOG4107RGM aldo keto reductase HP433_RS11390 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HP433_RS11395 ENOG4105DSW Fusaric acid resistance protein HP433_RS11400 ENOG4105Y49 secretion protein, HlyD family HP433_RS11415 ENOG4108XTF Outer Membrane Lipoprotein HP433_RS11425 ENOG410642K Lysozyme inhibitor HP433_RS11440 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HP433_RS11445 ENOG4108K3A Glutathione S-transferase HP433_RS11450 ENOG4105DUX Transporter HP433_RS11455 ENOG4105CSM endonuclease III HP433_RS11465 ENOG4108UQQ Electron transport complex HP433_RS11490 ENOG4105M9B inner membrane protein ydgK HP433_RS11495 ENOG4105QZ5 OriC-binding nucleoid-associated protein HP433_RS11500 ENOG4106C6R beta-lactam resistance protein HP433_RS11505 ENOG4105D9R oxidoreductase HP433_RS11515 ENOG4105C87 Aminotransferase class I and II HP433_RS11520 ENOG4105CI1 PTS System HP433_RS11525 ENOG4107P2S Transcriptional regulator HP433_RS11530 ENOG4107ZQV short-chain dehydrogenase reductase HP433_RS11535 ENOG4105XEA Tetr family transcriptional regulator HP433_RS11540 ENOG4105CNT hydrolase family 2 HP433_RS11545 ENOG4105CT4 transporter HP433_RS11550 ENOG4108QNI outer membrane porin protein HP433_RS11555 ENOG4106J39 exported protein HP433_RS11560 ENOG4105EIP mannose-6-phosphate isomerase HP433_RS11565 ENOG4107GFK fumarate HP433_RS11570 ENOG4105C9Q fumarate hydratase class II HP433_RS11580 ENOG4105JJR Histidine kinase HP433_RS11585 ENOG4107EXC regulatoR HP433_RS11590 ENOG4105RA2 Membrane HP433_RS11600 ENOG4105D5Q Arginine ornithine antiporter HP433_RS11605 ENOG4105C5D exported protein HP433_RS11610 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HP433_RS11615 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HP433_RS11620 ENOG4105DSF transport protein HP433_RS11635 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HP433_RS11650 ENOG4105D94 Major Facilitator Superfamily HP433_RS11655 ENOG4106NZI LysR family Transcriptional regulator HP433_RS11660 ENOG4105DAG ROK family HP433_RS11665 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HP433_RS11675 ENOG4108NEM leader-binding protein dmsD HP433_RS11680 ENOG4107KGK dmso reductase anchor subunit HP433_RS11685 ENOG4105QAX Iron-sulfur HP433_RS11690 ENOG4105C3J Cysteine desulfurase HP433_RS11695 ENOG4107QY8 reductase HP433_RS11700 ENOG4105KBG Protein of unknown function (DUF1161) HP433_RS11705 ENOG4105D69 UPF0257 lipoprotein ynfC HP433_RS11710 ENOG4108MK9 spermidine N(1)-acetyltransferase HP433_RS11760 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HP433_RS11785 ENOG4105WI6 cell killing protein encoded within cryptic prophage HP433_RS11795 ENOG4108MXB Protein of unknown function (DUF968) HP433_RS11800 ENOG4105KSK (crossover) junction endodeoxyribonuclease HP433_RS11805 ENOG4105HGD Antitermination protein HP433_RS11835 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HP433_RS11855 ENOG4108X9F tail fiber protein HP433_RS11860 ENOG4105UZW Tail fiber assembly protein HP433_RS11875 ENOG4105DEI Mannitol dehydrogenase HP433_RS11880 ENOG41061EV selenium-binding protein YdfZ HP433_RS11885 ENOG4107XBN GntR Family Transcriptional Regulator HP433_RS11890 ENOG4105EMU Dehydrogenase HP433_RS11895 ENOG4105DGW oligopeptidase A HP433_RS11900 ENOG4108WTK competence damage-inducible protein HP433_RS11905 ENOG4108YDI single-species biofilm formation on inanimate substrate HP433_RS11910 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HP433_RS11920 ENOG4105E5W Transporter HP433_RS11925 ENOG4108594 Permease of the drug metabolite transporter HP433_RS11930 ENOG4105FDP GntR family transcriptional regulator HP433_RS11940 ENOG4105CK1 PTS System HP433_RS11945 ENOG4105VCP PTS System HP433_RS11955 ENOG4105CS2 ec 3.2.1.21 HP433_RS11960 ENOG4106DNR multiple antibiotic resistance protein HP433_RS11965 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HP433_RS11970 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HP433_RS11990 ENOG4105EGI Transcriptional regulator HP433_RS11995 ENOG4105C26 Dehydrogenase HP433_RS12000 ENOG4105CSV Glutaminase HP433_RS12005 ENOG4105M0C cytoplasmic protein HP433_RS12010 ENOG4105BZU Histidine kinase HP433_RS12020 ENOG4105FFC UPF0187 protein HP433_RS12030 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HP433_RS12055 ENOG4105C2J ABC transporter HP433_RS12085 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HP433_RS12090 ENOG4105CAF HipA N-terminal domain protein HP433_RS12100 ENOG4108RQP Major type 1 subunit fimbrin HP433_RS12110 ENOG4105CW0 outer membrane usher protein HP433_RS12115 ENOG4108WDE Fimbrial protein HP433_RS12120 ENOG4106318 fimbrial-like protein YdeR HP433_RS12125 ENOG4106PIH fimbrial-like protein ydeQ HP433_RS12130 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HP433_RS12140 ENOG4105Z68 AraC Family Transcriptional Regulator HP433_RS12145 ENOG4105ENH Sulfatase HP433_RS12150 ENOG4105C4X radical SAM domain protein HP433_RS12160 ENOG4105CQ0 ABC transporter HP433_RS12170 ENOG4105CQ0 ABC transporter HP433_RS12175 ENOG4105PE1 Receptor HP433_RS12180 ENOG4107RAN Peptidase, M16 HP433_RS12185 ENOG4105CVK Glutamate decarboxylase HP433_RS12190 ENOG4105E5D amino acid HP433_RS12195 ENOG4105F32 YngK protein HP433_RS12205 ENOG4105BZU Histidine kinase HP433_RS12210 ENOG4108UQS dipeptidase HP433_RS12215 ENOG4105DEF Extracellular solute-binding protein, family 5 HP433_RS12220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP433_RS12225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP433_RS12230 ENOG4105C3U ABC transporter HP433_RS12235 ENOG4107H6U ABC transporter HP433_RS12240 ENOG4108Z9K Osmotically inducible protein HP433_RS12245 ENOG4105TPS biofilm-dependent modulation protein HP433_RS12250 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HP433_RS12260 ENOG4105DQ4 alcohol dehydrogenase HP433_RS12265 ENOG41084S7 Plasmid maintenance system antidote protein HP433_RS12270 ENOG4108MG3 formate dehydrogenase HP433_RS12275 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP433_RS12285 ENOG4105RPH Inner membrane protein YddG HP433_RS12300 ENOG4107QND Nitrite extrusion protein HP433_RS12305 ENOG4105CRU nitrate reductase, alpha subunit HP433_RS12310 ENOG4108IUE nitrate reductase beta subunit HP433_RS12315 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HP433_RS12320 ENOG4105D0D Nitrate reductase 2, gamma subunit HP433_RS12325 ENOG4105JAB phenazine biosynthesis protein, phzf family HP433_RS12330 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HP433_RS12335 ENOG4108MEJ flavin reductase domain protein HP433_RS12370 ENOG4108N27 Glutathione S-transferase HP433_RS12375 ENOG4105C85 amino acid HP433_RS12380 ENOG4108NS2 receptor HP433_RS12385 ENOG4105CHB tonB-dependent Receptor HP433_RS12390 ENOG4108WYP Transcriptional regulator HP433_RS12395 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HP433_RS12400 ENOG4108Z7F N-acetyltransferase HP433_RS12405 ENOG4108T9Y Inner membrane protein ydcZ HP433_RS12410 ENOG4105R71 cytoplasmic protein HP433_RS12415 ENOG410654E Membrane HP433_RS12445 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HP433_RS12450 ENOG4105D81 ABC transporter, permease HP433_RS12455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HP433_RS12460 ENOG4107TYH extracellular solute-binding protein family 1 HP433_RS12465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HP433_RS12470 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HP433_RS12480 ENOG4105RR0 Protein of unknown function (DUF2554) HP433_RS12485 ENOG4105CFP Peptidase U32 HP433_RS12490 ENOG4108JCI Transcriptional regulator HP433_RS12495 ENOG4105DKK Benzoate HP433_RS12500 ENOG4105D7V transposase HP433_RS12510 ENOG4108KKZ (LipO)protein HP433_RS12515 ENOG41088CC tellurite resistance protein tehB HP433_RS12520 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HP433_RS12525 ENOG4107WE3 acetyltransferase YdcK HP433_RS12530 ENOG4108Z9I -acetyltransferase HP433_RS12535 ENOG4105Z2P Protein of unknown function (DUF465) HP433_RS12545 ENOG4105E32 cytoplasmic protein HP433_RS12550 ENOG4105DDW LysR family Transcriptional regulator HP433_RS12555 ENOG4105C8Q Methyl-accepting chemotaxis HP433_RS12560 ENOG4107NK6 Hok/gef family HP433_RS12565 ENOG4105UPP uncharacterized protein ydcA HP433_RS12570 ENOG4105CPW cytochrome b561 HP433_RS12575 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HP433_RS12580 ENOG4105C26 Dehydrogenase HP433_RS12585 ENOG4107DB1 DUF218 domain HP433_RS12590 ENOG4105CQ7 ATP-dependent helicase HP433_RS12600 ENOG41077RS Phosphatase HP433_RS12605 ENOG4105E8V Alpha Beta Hydrolase Fold protein HP433_RS12610 ENOG4108HPI phosphatidate Cytidylyltransferase HP433_RS12615 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HP433_RS12625 ENOG4107S5I aldo keto reductase HP433_RS12630 ENOG4108Z0R Transferase HP433_RS12635 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HP433_RS12640 ENOG4105DZS Phenylacetate-CoA ligase HP433_RS12645 ENOG4105CHU acetyl-coa acetyltransferase HP433_RS12650 ENOG4108ZJI phenylacetic acid degradation protein HP433_RS12655 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HP433_RS12660 ENOG4108UKI Enoyl-CoA hydratase HP433_RS12665 ENOG4105E39 Enoyl-CoA hydratase HP433_RS12670 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HP433_RS12675 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HP433_RS12680 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HP433_RS12685 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HP433_RS12690 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HP433_RS12695 ENOG4105DXM phenylacetic acid degradation protein HP433_RS12705 ENOG4105C26 Dehydrogenase HP433_RS12710 ENOG4108WFR AraC Family Transcriptional Regulator HP433_RS12715 ENOG4105WXT Conserved Protein HP433_RS12720 ENOG410689M (LipO)protein HP433_RS12725 ENOG4107H52 Dicarboxylate transport HP433_RS12730 ENOG4105C5I Dehydrogenase HP433_RS12735 ENOG41090X5 Heat shock protein hslJ HP433_RS12740 ENOG4105IKK cytoplasmic protein HP433_RS12745 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HP433_RS12750 ENOG4105FCK Membrane HP433_RS12755 ENOG4108RW8 Universal stress protein F HP433_RS12765 ENOG4105W3V DNA-binding, transcriptional regulator HP433_RS12800 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HP433_RS12810 ENOG4105KUS lysozyme HP433_RS12815 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HP433_RS12825 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HP433_RS12835 ENOG4105RWQ Protein of unknown function (DUF1364) HP433_RS12850 ENOG4105F27 Major Facilitator HP433_RS12855 ENOG4108NH8 Cation transport protein HP433_RS12870 ENOG4105C94 Transporter HP433_RS12880 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HP433_RS12915 ENOG4107C82 Rac prophage HP433_RS12925 ENOG41076J9 exonuclease VIII HP433_RS12930 ENOG4108PNI recT protein HP433_RS12935 ENOG4106YAH restriction alleviation and modification enhancement HP433_RS12940 ENOG41070YT Rac prophage HP433_RS12945 ENOG4107160 Rac prophage HP433_RS12950 ENOG4107R08 Integrase HP433_RS12960 ENOG4105C1J atp-dependent rna helicase HP433_RS12970 ENOG4105BZU Histidine kinase HP433_RS12975 ENOG4108DG9 Smr protein MutS2 HP433_RS12980 ENOG4106KR7 LysR family Transcriptional regulator HP433_RS12985 ENOG4105CH2 amidohydrolase HP433_RS12990 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HP433_RS12995 ENOG4105CFC Transporter HP433_RS13000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HP433_RS13005 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HP433_RS13010 ENOG4105Q9Y Universal stress protein HP433_RS13015 ENOG4105S5I Membrane HP433_RS13020 ENOG4105D64 Mechanosensitive ion channel HP433_RS13025 ENOG4107QSI ABC, transporter HP433_RS13030 ENOG4105EQ2 LysR family Transcriptional regulator HP433_RS13035 ENOG4105ENX hydrolase HP433_RS13040 ENOG4105ENX hydrolase HP433_RS13050 ENOG4105KXI murein peptide amidase A HP433_RS13055 ENOG4107S8C mandelate racemase muconate lactonizing HP433_RS13060 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HP433_RS13065 ENOG4108JU8 Transcriptional regulator HP433_RS13075 ENOG4105CM6 amino acid regulated cytosolic protein HP433_RS13080 ENOG4105FKQ transcriptional regulator HP433_RS13085 ENOG4107EFV Outer membrane protein G HP433_RS13090 ENOG4108IJ9 (ABC) transporter HP433_RS13095 ENOG4107URF beta-phospho-glucomutase HP433_RS13100 ENOG4105C71 hydrolase family 65, central catalytic HP433_RS13105 ENOG4105CK5 oxidoreductase HP433_RS13110 ENOG4107TYA transient receptor potential locus HP433_RS13115 ENOG4107RRD Dehydrogenase HP433_RS13120 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HP433_RS13125 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HP433_RS13130 ENOG4105WEM extracellular solute-binding protein HP433_RS13135 ENOG4107QW3 Sucrose phosphorylase HP433_RS13140 ENOG4105K8Z Phage shock protein HP433_RS13145 ENOG4105NNG Peripheral inner membrane phage-shock protein HP433_RS13150 ENOG4105FM1 phage shock protein C HP433_RS13155 ENOG4105YYT phage shock protein B HP433_RS13160 ENOG41087YS Phage shock protein A HP433_RS13165 ENOG4105E51 psp operon transcriptional activator HP433_RS13170 ENOG4108JPW Aminotransferase HP433_RS13175 ENOG4105CJP fad dependent oxidoreductase HP433_RS13180 ENOG4105C26 Dehydrogenase HP433_RS13185 ENOG4107VRI Transcriptional regulator HP433_RS13190 ENOG4108Z86 Glutamine amidotransferase HP433_RS13195 ENOG4105CFQ glutamine synthetase HP433_RS13205 ENOG4105CUB amino acid HP433_RS13210 ENOG4105N0E Protein of unknown function (DUF2543) HP433_RS13215 ENOG4108HIY periplasmic HP433_RS13220 ENOG4108I5W peptide transport system, permease protein HP433_RS13225 ENOG4108EU3 peptide transport system, permease HP433_RS13230 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HP433_RS13235 ENOG4108JQ2 peptide transport system atp-binding protein HP433_RS13240 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HP433_RS13245 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HP433_RS13250 ENOG4105Q4T oxidoreductase HP433_RS13265 ENOG4105BZU Histidine kinase HP433_RS13270 ENOG410643D UPF0509 protein HP433_RS13275 ENOG4105N2W Transcriptional regulator HP433_RS13285 ENOG4108ZJT translation initiation factor, Sui1 HP433_RS13295 ENOG4105CFV Tetratricopeptide repeat protein HP433_RS13300 ENOG4105Q4A inner membrane protein yciS HP433_RS13305 ENOG4105EYK Phosphatidylglycerophosphatase B HP433_RS13315 ENOG4107QM5 aconitate hydratase HP433_RS13335 ENOG4107R11 Transcriptional regulator HP433_RS13340 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HP433_RS13345 ENOG4105RKX Protein of unknown function (DUF2498) HP433_RS13350 ENOG4105ERU peptidase HP433_RS13355 ENOG4105UBK short-chain dehydrogenase reductase HP433_RS13360 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HP433_RS13365 ENOG4105FE9 pseudouridine synthase HP433_RS13370 ENOG4107RTD sua5 ycio yrdc ywlc family protein HP433_RS13375 ENOG4105DB7 PHP domain protein HP433_RS13385 ENOG4105CRQ synthase (Component I) HP433_RS13390 ENOG4108EFP Anthranilate synthase component II HP433_RS13395 ENOG4105DK0 Indole-3-glycerol phosphate synthase HP433_RS13415 ENOG4108Z9Z response to DNA damage stimulus HP433_RS13425 ENOG4105EIF outer membrane protein W HP433_RS13445 ENOG4105NAU thioesterase Superfamily protein HP433_RS13450 ENOG410822N TonB family HP433_RS13455 ENOG4105K9H YciI-like protein HP433_RS13460 ENOG4107SVH Potassium channel protein HP433_RS13480 ENOG4108JQ7 (ABC) transporter HP433_RS13485 ENOG4105C3U ABC transporter HP433_RS13490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HP433_RS13495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HP433_RS13500 ENOG4108J59 Extracellular solute-binding protein, family 5 HP433_RS13510 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HP433_RS13515 ENOG4105C0A alcohol dehydrogenase HP433_RS13525 ENOG4107104 thymidine kinase HP433_RS13530 ENOG4108SAU DNA-binding protein H-ns HP433_RS13535 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HP433_RS13540 ENOG4105I93 response regulator HP433_RS13545 ENOG4105D78 K07001 NTE family protein HP433_RS13550 ENOG4105K5B UPF0225 protein HP433_RS13555 ENOG4105CIY formyltetrahydrofolate deformylase HP433_RS13575 ENOG41076YT nitrate reductase, gamma subunit HP433_RS13580 ENOG4105R3A Nitrate reductase HP433_RS13585 ENOG4108IUE nitrate reductase beta subunit HP433_RS13590 ENOG4105CRU nitrate reductase, alpha subunit HP433_RS13595 ENOG4105DQQ Major facilitator superfamily MFS_1 HP433_RS13600 ENOG4105BZU Histidine kinase HP433_RS13605 ENOG4105WH1 Two component transcriptional regulator luxr family HP433_RS13610 ENOG4105ID0 Putative invasin HP433_RS13615 ENOG41090EX DsrE family HP433_RS13620 ENOG4108NH8 Cation transport protein HP433_RS13625 ENOG4105WS7 Cation transport regulator HP433_RS13630 ENOG4105EWV Sodium calcium exchanger membrane region HP433_RS13655 ENOG41063JG Transcriptional regulator HP433_RS13660 ENOG4108YY7 Invasion gene expression up-regulator SirB HP433_RS13665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HP433_RS13690 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HP433_RS13695 ENOG4105CHH sulfate transporter HP433_RS13700 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HP433_RS13710 ENOG4105C3G gtp-binding protein HP433_RS13715 ENOG4105I1J Autotransporter HP433_RS13720 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HP433_RS13725 ENOG4105CMT Dihydroxyacetone kinase HP433_RS13730 ENOG4108UTZ Dihydroxyacetone kinase HP433_RS13735 ENOG4105VDH Dihydroxyacetone kinase HP433_RS13755 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HP433_RS13765 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HP433_RS13775 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HP433_RS13785 ENOG4105ED1 spovr family HP433_RS13800 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HP433_RS13805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HP433_RS13810 ENOG4105KT5 UmuD protein HP433_RS13815 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HP433_RS13825 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HP433_RS13835 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HP433_RS13840 ENOG4105S66 prophage protein HP433_RS13850 ENOG4107QMS site-determining protein HP433_RS13885 ENOG410658X HP433_RS13905 ENOG4105BZU Histidine kinase HP433_RS13910 ENOG410738I uncharacterized protein ymgC HP433_RS13920 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HP433_RS13925 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HP433_RS13930 ENOG4105F9F transposase HP433_RS13935 ENOG4105BZU Histidine kinase HP433_RS13940 ENOG4108XDN Transcriptional regulator HP433_RS13945 ENOG41064WM Uncharacterized protein YcgX HP433_RS13960 ENOG4108HMX isocitrate dehydrogenase (NADP) HP433_RS13965 ENOG4108R99 pseudouridine synthase HP433_RS13985 ENOG4107QTF adenylosuccinate lyase HP433_RS13990 ENOG4105XJC Two component transcriptional regulator (Winged helix family HP433_RS13995 ENOG4105IFJ Histidine kinase HP433_RS14000 ENOG4105EZE Cupin 4 family protein HP433_RS14020 ENOG4105D38 putrescine abc transporter HP433_RS14025 ENOG4107RUE extracellular solute-binding protein family 1 HP433_RS14040 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HP433_RS14050 ENOG4105D60 lipoprotein releasing system transmembrane protein HP433_RS14055 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HP433_RS14060 ENOG4105D60 lipoprotein releasing system transmembrane protein HP433_RS14065 ENOG4105IQC Inner membrane protein YcfT HP433_RS14070 ENOG4108JA2 transcriptioN-repair coupling factor HP433_RS14075 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HP433_RS14080 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HP433_RS14085 ENOG4108IND Tetr family transcriptional regulator HP433_RS14090 ENOG4107MBR 17 kDa surface antigen HP433_RS14095 ENOG4105CEP NADH dehydrogenase HP433_RS14115 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HP433_RS14120 ENOG41090DQ Lipoprotein HP433_RS14125 ENOG4105K59 histidine triad (HIT) protein HP433_RS14130 ENOG4105CNM Receptor HP433_RS14135 ENOG4105CI1 PTS System HP433_RS14140 ENOG4105F8V Hydrolase, tatD family HP433_RS14145 ENOG4107QRG dna polymerase iii HP433_RS14155 ENOG4105HHA aminodeoxychorismate lyase HP433_RS14160 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HP433_RS14165 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HP433_RS14170 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HP433_RS14175 ENOG4105CHR reductase HP433_RS14180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HP433_RS14200 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HP433_RS14205 ENOG4108UHJ MAF-like protein HP433_RS14210 ENOG4105EI2 Pseudouridine synthase HP433_RS14215 ENOG4107QQB Ribonuclease E HP433_RS14220 ENOG4105DTJ flagellar hook-associated protein HP433_RS14225 ENOG4105E1Q flagellar hook-associated protein HP433_RS14230 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HP433_RS14245 ENOG4105CGA flagellar basal-body rod protein FlgG HP433_RS14250 ENOG4108KPB Flagellar basal-body rod protein FlgF HP433_RS14255 ENOG4105BZE flagellar hook protein, FlgE HP433_RS14260 ENOG4105W00 Flagellar hook capping protein HP433_RS14265 ENOG4108ZC9 flagellar basal-body rod protein flgc HP433_RS14270 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HP433_RS14275 ENOG4105CKS Flagella basal body P-ring formation protein flgA HP433_RS14280 ENOG4105M9M anti-sigma28 factor FlgM HP433_RS14285 ENOG4105QVD Flagella synthesis protein FlgN HP433_RS14290 ENOG4105CJR Integral membrane protein (MviN HP433_RS14295 ENOG4105EP9 oxidoreductase HP433_RS14305 ENOG4105D9U N-acetyltransferase HP433_RS14315 ENOG4105E9S glutaredoxin 2 HP433_RS14320 ENOG4105F3T (LipO)protein HP433_RS14330 ENOG4105MEA DNA damage-inducible protein i HP433_RS14335 ENOG4105PVA Biofilm formation regulatory protein BssS HP433_RS14345 ENOG4106974 biofilm formation HP433_RS14350 ENOG4105DS1 cytochrome b561 HP433_RS14355 ENOG4108YYC ycei family HP433_RS14365 ENOG4105D1S lipid A biosynthesis HP433_RS14375 ENOG4108W47 Acidic protein msyB HP433_RS14380 ENOG4105NAC (LipO)protein HP433_RS14385 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HP433_RS14400 ENOG4107RZC phospholipase d HP433_RS14405 ENOG4108UVJ appr-1-p processing domain protein HP433_RS14420 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HP433_RS14425 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HP433_RS14430 ENOG41086KC Transcriptional regulator HP433_RS14435 ENOG4108XDW curli assembly protein CsgE HP433_RS14440 ENOG4108WYR Curli production assembly transport component, CsgF HP433_RS14445 ENOG4105P8Q Curli production assembly transport component CsgG HP433_RS14450 ENOG4108UQ5 membrane protein YcdZ HP433_RS14455 ENOG4107XHZ cytoplasmic chaperone TorD family protein HP433_RS14465 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HP433_RS14480 ENOG4108T85 Membrane HP433_RS14495 ENOG4105BZU Histidine kinase HP433_RS14500 ENOG4108TUY outer membrane protein PgaA HP433_RS14505 ENOG4107BJW polysaccharide deacetylase HP433_RS14510 ENOG4105CND Glycosyl transferase, family 2 HP433_RS14520 ENOG4105D5M phosphate starvation-inducible protein HP433_RS14525 ENOG4105DBE peroxidase HP433_RS14530 ENOG410650H (LipO)protein HP433_RS14540 ENOG4105CK7 Sodium proline symporter HP433_RS14550 ENOG4105C26 Dehydrogenase HP433_RS14555 ENOG4108R86 Transcriptional regulator HP433_RS14590 ENOG4105C2W permease HP433_RS14595 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HP433_RS14605 ENOG4105XH3 HP433_RS14610 ENOG4105D6F Phosphatase HP433_RS14635 ENOG4107QY8 reductase HP433_RS14640 ENOG4105CUW cytochrome C-TYPE protein HP433_RS14645 ENOG4106WF9 DNA-binding transcriptional regulator TorR HP433_RS14650 ENOG4108SV3 Tmao reductase system periplasmic protein tort HP433_RS14655 ENOG4105BZU Histidine kinase HP433_RS14660 ENOG4105HEE Binding Domain protein HP433_RS14665 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HP433_RS14680 ENOG4105VEQ Cold shock protein HP433_RS14685 ENOG41060EU Cold shock-like protein HP433_RS14695 ENOG4108Y9B (LipO)protein HP433_RS14700 ENOG4108W78 Pfam:DUF1017 HP433_RS14705 ENOG4105E3R (LipO)protein HP433_RS14710 ENOG4105DAY polysaccharide export protein HP433_RS14715 ENOG4107ZF2 Phosphatase HP433_RS14720 ENOG4105D75 Capsular exopolysaccharide family HP433_RS14725 ENOG4105D6F Phosphatase HP433_RS14735 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HP433_RS14740 ENOG4105C4M (Ubiquinol oxidase) subunit I HP433_RS14745 ENOG4105MVP hydrogenase-1 operon protein HyaF HP433_RS14750 ENOG4108VXY Hydrogenase-1 operon protein HyaE HP433_RS14755 ENOG4108USZ hydrogenase HP433_RS14760 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HP433_RS14765 ENOG4105DPX Hydrogenase, large subunit HP433_RS14770 ENOG4105E3S small subunit HP433_RS14780 ENOG4108MN8 Membrane HP433_RS14785 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HP433_RS14790 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HP433_RS14805 ENOG4105K4P CoA-binding domain protein HP433_RS14820 ENOG41088T4 Helicase IV HP433_RS14825 ENOG410901E Membrane HP433_RS14830 ENOG4105EM2 membrane HP433_RS14835 ENOG4108RZ1 DNA transformation protein HP433_RS14845 ENOG4105UYK outer membrane protein a HP433_RS14855 ENOG4105DAN ATP-dependent protease HP433_RS14865 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HP433_RS14870 ENOG4108Q2G (LipO)protein HP433_RS14875 ENOG4105DY2 Paraquat-inducible protein b HP433_RS14880 ENOG4105F1S paraquat-inducible protein a HP433_RS14885 ENOG4105C5H ABC transporter HP433_RS14895 ENOG4105QVC MOSC domain-containing protein HP433_RS14900 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HP433_RS14910 ENOG4106PH7 chaperone HP433_RS14915 ENOG4105MX3 Fimbrial HP433_RS14920 ENOG4105Q7J Fimbrial HP433_RS14925 ENOG4108MDY Fimbrial HP433_RS14930 ENOG4105CW0 outer membrane usher protein HP433_RS14935 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HP433_RS14940 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HP433_RS14945 ENOG4108UZX fmn reductase HP433_RS14950 ENOG4105GVF (ABC) transporter HP433_RS14960 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HP433_RS14970 ENOG4105CD8 aminopeptidase N HP433_RS14985 ENOG4105FCK Membrane HP433_RS14990 ENOG4105CGF Aromatic amino acid aminotransferase HP433_RS14995 ENOG4105C5X domain protein HP433_RS15000 ENOG4105EAQ (twin-arginine translocation) pathway signal HP433_RS15005 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HP433_RS15010 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HP433_RS15015 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HP433_RS15025 ENOG4106371 Methyltransferase HP433_RS15030 ENOG4107S90 membrAne HP433_RS15035 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HP433_RS15050 ENOG4105T0Z Conserved Protein HP433_RS15060 ENOG4105BZ1 (ABC) transporter HP433_RS15065 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HP433_RS15075 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HP433_RS15085 ENOG4108K0D peptidase, M48 HP433_RS15100 ENOG4107VMU Membrane HP433_RS15105 ENOG4105DDY UPF0142 protein ycaO HP433_RS15110 ENOG4105TMB Formate nitrite transporter HP433_RS15115 ENOG4105C6N Formate acetyltransferase HP433_RS15120 ENOG4105F1A Pyruvate formate-lyase HP433_RS15125 ENOG4108X0B nad(p)h dehydrogenase (quinone) HP433_RS15130 ENOG410642W LysR family Transcriptional regulator HP433_RS15135 ENOG4105E5D amino acid HP433_RS15145 ENOG4105CHJ isochorismatase hydrolase HP433_RS15150 ENOG4107KGK dmso reductase anchor subunit HP433_RS15155 ENOG4105QAX Iron-sulfur HP433_RS15160 ENOG4107QY8 reductase HP433_RS15170 ENOG4105D1H recombination factor protein RarA HP433_RS15180 ENOG4105CNU cell division protein FtsK HP433_RS15190 ENOG4105C3M thioredoxin reductase HP433_RS15195 ENOG4108JJ9 ABC, transporter HP433_RS15200 ENOG4108JJ8 (ABC) transporter HP433_RS15210 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HP433_RS15220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HP433_RS15230 ENOG4105VEQ Cold shock protein HP433_RS15240 ENOG4105DJY efflux transporter, rnd family, mfp subunit HP433_RS15245 ENOG4108MJ5 VirK protein HP433_RS15250 ENOG4105CPB ATP-dependent endonuclease of the OLD family HP433_RS15255 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HP433_RS15260 ENOG4105DWU Membrane HP433_RS15270 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HP433_RS15275 ENOG4105C7K acetolactate synthase HP433_RS15280 ENOG4105C5W Aldolase HP433_RS15285 ENOG4105CGD Nad-dependent epimerase dehydratase HP433_RS15290 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HP433_RS15295 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HP433_RS15305 ENOG41064MM (LipO)protein HP433_RS15310 ENOG4105E5Z arginine transporter ATP-binding subunit HP433_RS15315 ENOG4106PMH Extracellular solute-binding protein family 3 HP433_RS15320 ENOG4105GBT ABC transporter HP433_RS15325 ENOG4105DMR ABC, transporter HP433_RS15330 ENOG4106TNF Periplasmic binding protein HP433_RS15340 ENOG4105RBQ inner membrane protein ybjO HP433_RS15345 ENOG4105D38 putrescine abc transporter HP433_RS15350 ENOG4105F38 ABC transporter, permease HP433_RS15355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HP433_RS15360 ENOG4107RUE extracellular solute-binding protein family 1 HP433_RS15365 ENOG4108RMJ sensory transduction regulator HP433_RS15375 ENOG4108DBC nitroreductase HP433_RS15380 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HP433_RS15385 ENOG41090BQ Glutaredoxin HP433_RS15390 ENOG4105GWF inner membrane protein YbjM HP433_RS15400 ENOG4108RFG Tetr family transcriptional regulator HP433_RS15405 ENOG4106UW1 Major Facilitator superfamily HP433_RS15410 ENOG4108HCJ Hydrolase HP433_RS15420 ENOG4107QF7 multi-drug HP433_RS15425 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HP433_RS15430 ENOG4107FB0 transcriptional regulator DeoR family HP433_RS15435 ENOG4105DZ1 carboxypeptidase HP433_RS15440 ENOG4108TGY Glutathione S-transferase HP433_RS15445 ENOG4105D8V Glucose sorbosone dehydrogenase HP433_RS15450 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HP433_RS15460 ENOG41064RH membrane protein YliF HP433_RS15465 ENOG4105BZU Histidine kinase HP433_RS15490 ENOG4105D44 asparaginase HP433_RS15495 ENOG4105CVM Molybdenum cofactor synthesis domain protein HP433_RS15500 ENOG4105D06 uba thif-type nad fad binding protein HP433_RS15505 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP433_RS15510 ENOG4105F1A Pyruvate formate-lyase HP433_RS15520 ENOG4108HCJ Hydrolase HP433_RS15525 ENOG41072TH Protein of unknown function (DUF1479) HP433_RS15535 ENOG4105C5H ABC transporter HP433_RS15540 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HP433_RS15545 ENOG4105F4P )-transporter HP433_RS15550 ENOG4105KST dependent repressor HP433_RS15560 ENOG4108I6E Sulfatase HP433_RS15565 ENOG4108T1M outer membrane protein x HP433_RS15575 ENOG4107AQZ Membrane HP433_RS15585 ENOG4107R0W ABC transporter HP433_RS15590 ENOG4105E5Q amino acid AbC transporter HP433_RS15595 ENOG4105CDA abc transporter atp-binding protein HP433_RS15600 ENOG4105D8X mechanosensitive ion channel HP433_RS15610 ENOG4105ZY9 UPF0379 protein ybiM HP433_RS15615 ENOG4108IU3 tonb-dependent siderophore receptor HP433_RS15625 ENOG4105KSC Transcriptional regulator, TraR DksA family HP433_RS15630 ENOG4105VR4 UPF0379 protein ybiJ HP433_RS15635 ENOG4105DG4 malate L-lactate dehydrogenase HP433_RS15640 ENOG4108MTB glycosyl transferase family HP433_RS15645 ENOG4105DVT helicase HP433_RS15650 ENOG4108UV1 cellular component movement HP433_RS15655 ENOG4105C1J atp-dependent rna helicase HP433_RS15660 ENOG4107MVR Transcriptional regulator HP433_RS15670 ENOG4105CJ1 ABC, transporter HP433_RS15675 ENOG4107QWP ABC-2 type transporter HP433_RS15680 ENOG4107QWP ABC-2 type transporter HP433_RS15685 ENOG4105I9U inner membrane protein ybhQ HP433_RS15690 ENOG4105X23 Endonuclease Exonuclease phosphatase HP433_RS15695 ENOG4105DZQ phospholipase D Transphosphatidylase HP433_RS15700 ENOG4107UXM Membrane HP433_RS15715 ENOG4105HFZ Membrane HP433_RS15720 ENOG4108ZAF Molybdopterin HP433_RS15725 ENOG4105M00 molybdopterin converting factor, subunit 1 HP433_RS15735 ENOG4108RIR Molybdenum cofactor biosynthesis protein HP433_RS15745 ENOG4105CHW UPF0052 protein HP433_RS15755 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HP433_RS15760 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HP433_RS15775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HP433_RS15780 ENOG4108V1U phospholipid-binding protein HP433_RS15785 ENOG4105NBR Pectinesterase HP433_RS15790 ENOG4107QM5 aconitate hydratase HP433_RS15795 ENOG4107QPK )-transporter HP433_RS15800 ENOG4105C7F AcnD-accessory protein PrpF HP433_RS15805 ENOG4105F04 LysR family Transcriptional regulator HP433_RS15825 ENOG4108K4B hydrolase HP433_RS15835 ENOG4105E0C molybdate abc transporter HP433_RS15840 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HP433_RS15850 ENOG4105F4R Transcriptional regulator mode HP433_RS15855 ENOG4105DKW ABC transporter HP433_RS15860 ENOG4105CMR udp-glucose 4-epimerase HP433_RS15865 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HP433_RS15875 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HP433_RS15885 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HP433_RS15890 ENOG4105JND homeobox protein HP433_RS15895 ENOG4105PGM cation diffusion facilitator family transporter HP433_RS15900 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HP433_RS15945 ENOG4105UFD tol-pal system protein YbgF HP433_RS15950 ENOG4105KCK Peptidoglycan-associated lipoprotein HP433_RS15960 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HP433_RS15970 ENOG4105E02 MotA TolQ exbB proton channel HP433_RS15975 ENOG4107YD3 Thioesterase HP433_RS15980 ENOG4105KJB cyd operon protein YbgE HP433_RS15990 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HP433_RS15995 ENOG4105C4M (Ubiquinol oxidase) subunit I HP433_RS16000 ENOG4105C8I hydrolase, family 38 HP433_RS16005 ENOG4105DM4 PTS System HP433_RS16010 ENOG4105FDP GntR family transcriptional regulator HP433_RS16015 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HP433_RS16025 ENOG4105C7S Dehydrogenase HP433_RS16030 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HP433_RS16035 ENOG4105E33 succinate dehydrogenase HP433_RS16040 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HP433_RS16045 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HP433_RS16050 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HP433_RS16060 ENOG4105BZN citrate synthase HP433_RS16065 ENOG4106UBK fimbrial-like adhesin protein HP433_RS16070 ENOG4106PG1 outer membrane usher protein HP433_RS16075 ENOG4108TTM chaperone HP433_RS16080 ENOG4108MY7 Fimbrial HP433_RS16085 ENOG4108KK1 membrane protein AbrB duplication HP433_RS16095 ENOG4105E7W lamb ycsf family protein HP433_RS16100 ENOG4107R7A Allophanate hydrolase subunit 2 HP433_RS16105 ENOG4105P4J Allophanate hydrolase, subunit 1 HP433_RS16110 ENOG4107QNR UPF0135 protein HP433_RS16115 ENOG4105DUX Transporter HP433_RS16120 ENOG4105CVP deoxyribo-dipyrimidine photolyase HP433_RS16125 ENOG4107SEY Conserved Protein HP433_RS16140 ENOG4106R09 HP433_RS16145 ENOG4105CNA YD repeat protein HP433_RS16150 ENOG41079JQ Membrane HP433_RS16155 ENOG4105CNA YD repeat protein HP433_RS16160 ENOG4105XIQ Protein of unknown function (DUF2517) HP433_RS16185 ENOG4105C08 Histidine kinase HP433_RS16190 ENOG4105EEX Two component transcriptional regulator (Winged helix family HP433_RS16210 ENOG4105CXN decarboxylase HP433_RS16215 ENOG4105D5Q Arginine ornithine antiporter HP433_RS16220 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HP433_RS16225 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HP433_RS16230 ENOG4105EV9 Alpha Beta Hydrolase HP433_RS16235 ENOG4105NNH LexA regulated protein HP433_RS16240 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HP433_RS16250 ENOG41090R7 Ferric uptake HP433_RS16255 ENOG4105GX6 (LipO)protein HP433_RS16270 ENOG4105CI1 PTS System HP433_RS16280 ENOG4105CE4 GlcNAc 6-P deacetylase HP433_RS16285 ENOG4105E2R ROK family HP433_RS16290 ENOG4105D4U had-superfamily hydrolase, subfamily iia HP433_RS16295 ENOG4105CAQ asparagine synthetase HP433_RS16335 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HP433_RS16345 ENOG4105C9A Phoh family HP433_RS16355 ENOG4108JU5 Magnesium and cobalt efflux protein HP433_RS16360 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HP433_RS16365 ENOG4107U91 Rhomboid family HP433_RS16370 ENOG4107RP9 extracellular solute-binding protein, family 3 HP433_RS16375 ENOG4105EAD ABC transporter HP433_RS16380 ENOG4105DRP amino acid AbC transporter HP433_RS16385 ENOG4105CDA abc transporter atp-binding protein HP433_RS16395 ENOG4105F7F Chaperone HP433_RS16400 ENOG4105QFC Hsc56 co-chaperone of HscC HP433_RS16405 ENOG41069CF Protein of unknown function (DUF1266) HP433_RS16415 ENOG4105QFC Hsc56 co-chaperone of HscC HP433_RS16420 ENOG41069CF Protein of unknown function (DUF1266) HP433_RS16425 ENOG4105EUU Sel1 domain protein repeat-containing protein HP433_RS16430 ENOG4107PAI alpha helical protein HP433_RS16445 ENOG4105DJF DNA polymerase III, delta' subunit HP433_RS16455 ENOG4108TGR phosphatase HP433_RS16460 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HP433_RS16470 ENOG4105CJN penicillin-binding protein HP433_RS16475 ENOG4105CNI cell division protein FtsW HP433_RS16480 ENOG4105K6T rare lipoprotein A HP433_RS16485 ENOG4105DZ1 carboxypeptidase HP433_RS16500 ENOG41064T2 transcriptional regulator, lysR family HP433_RS16510 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HP433_RS16530 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HP433_RS16535 ENOG4105CEE C4-dicarboxylate transporter HP433_RS16540 ENOG4106YYS transcriptional regulatory protein HP433_RS16545 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HP433_RS16560 ENOG4105DQS Transcriptional regulator HP433_RS16565 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HP433_RS16570 ENOG4105D3R alkyl hydroperoxide reductase HP433_RS16575 ENOG4108JU3 Alkyl hydroperoxide reductase HP433_RS16580 ENOG4108U51 Universal stress protein HP433_RS16585 ENOG4105E2A Dehydrogenase HP433_RS16590 ENOG4105NXH GreA GreB family elongation factor HP433_RS16595 ENOG4105KTS ribonuclease HP433_RS16600 ENOG4107QPK )-transporter HP433_RS16615 ENOG4105CHY citrate lyase, alpha HP433_RS16620 ENOG4105CI0 Citrate lyase HP433_RS16645 ENOG4105GTN ParB Domain Protein Nuclease HP433_RS16655 ENOG4107SCQ Iron-containing alcohol dehydrogenase HP433_RS16660 ENOG4105VCD cytoplasmic protein HP433_RS16665 ENOG4105D22 carbon starvation protein HP433_RS16670 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HP433_RS16675 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HP433_RS16680 ENOG4105WQI isochorismatase HP433_RS16685 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HP433_RS16690 ENOG4105E4F Isochorismate synthase HP433_RS16695 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HP433_RS16705 ENOG4105DQ5 transport system permease protein HP433_RS16710 ENOG4105TVJ transport system, permease HP433_RS16715 ENOG4105E0A ABC, transporter HP433_RS16720 ENOG4108QY5 Ferric enterobactin transport protein HP433_RS16725 ENOG4105C0W non-ribosomal peptide synthetase HP433_RS16730 ENOG41085A6 mbth domain-containing protein HP433_RS16735 ENOG4105E93 esterase HP433_RS16740 ENOG4107RNH Outer membrane receptor FepA HP433_RS16745 ENOG4108TSE Transferase HP433_RS16755 ENOG4107635 Hok Gef family protein HP433_RS16765 ENOG4105WQ6 Membrane HP433_RS16770 ENOG4105MSB protein, conserved in bacteria HP433_RS16775 ENOG4108RCM Nitroreductase HP433_RS16780 ENOG4105CUY Mechanosensitive ion channel HP433_RS16785 ENOG4105C85 amino acid HP433_RS16790 ENOG4108IJF Heavy metal efflux pump, CzcA HP433_RS16795 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HP433_RS16800 ENOG410624V efflux system protein HP433_RS16805 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HP433_RS16810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP433_RS16815 ENOG4105GR3 Histidine kinase HP433_RS16830 ENOG4105CNA YD repeat protein HP433_RS16855 ENOG410600T transposase HP433_RS16860 ENOG410802X bacteriophage n4 adsorption protein b HP433_RS16865 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HP433_RS16870 ENOG4105QUW HP433_RS16885 ENOG4108Q9V regulatoR HP433_RS16890 ENOG4108ZI2 Fimbrial protein HP433_RS16895 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HP433_RS16900 ENOG4105CW0 outer membrane usher protein HP433_RS16905 ENOG4108AF8 Chaperone HP433_RS16910 ENOG4108WDE Fimbrial protein HP433_RS16915 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HP433_RS16920 ENOG4105WQ3 Rna-binding protein HP433_RS16925 ENOG4105S2T inner membrane protein YbcI HP433_RS16935 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HP433_RS16945 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HP433_RS16950 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HP433_RS16955 ENOG4105C5B carbamate kinase HP433_RS16960 ENOG4105G5A Protein of unknown function (DUF2877) HP433_RS16965 ENOG4107REC cytoplasmic protein HP433_RS16970 ENOG4107R1Q Membrane protein FdrA HP433_RS16975 ENOG4105DG4 malate L-lactate dehydrogenase HP433_RS16980 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HP433_RS16985 ENOG4105S0E allantoin catabolism protein HP433_RS16990 ENOG4105BZW Glycerate kinase HP433_RS16995 ENOG4105DTE Xanthine uracil vitamin C permease HP433_RS17005 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HP433_RS17010 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HP433_RS17015 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HP433_RS17020 ENOG41060W2 glyoxylate carboligase HP433_RS17025 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HP433_RS17035 ENOG4107653 Transcriptional regulator HP433_RS17065 ENOG4105CNA YD repeat protein HP433_RS17070 ENOG4105CV6 ABC transporter, permease HP433_RS17075 ENOG4108I0Y (ABC) transporter HP433_RS17080 ENOG4108UJV acyl-CoA thioesterase i HP433_RS17085 ENOG4105E1F short-chain dehydrogenase reductase HP433_RS17090 ENOG4107QR8 Thioredoxin HP433_RS17095 ENOG4105C4B ABC transporter, permease HP433_RS17100 ENOG41083J0 (ABC) transporter HP433_RS17105 ENOG4107QX8 SPFH domain, Band 7 family protein HP433_RS17110 ENOG4105G5H Membrane HP433_RS17115 ENOG4108Z6Z Transcriptional regulator HP433_RS17120 ENOG4107RY6 amino acid HP433_RS17125 ENOG4105CSV Glutaminase HP433_RS17130 ENOG4105C59 p-type ATPase HP433_RS17135 ENOG41081XE plasmid maintenance system antidote protein, xre family HP433_RS17140 ENOG4105MBR gumn family HP433_RS17145 ENOG4108Z66 YbaK ebsC protein HP433_RS17150 ENOG4105CGH 5'-nucleotidase HP433_RS17155 ENOG4105EU0 Major facilitator Superfamily HP433_RS17160 ENOG4105CKD glutathione-regulated potassium-efflux system protein HP433_RS17165 ENOG4107RE1 Inosine-guanosine kinase HP433_RS17200 ENOG4107QMP dna polymerase iii subunits gamma and tau HP433_RS17210 ENOG4105WD1 Membrane HP433_RS17215 ENOG4108URS primosomal replication protein n'' HP433_RS17220 ENOG4106428 Protein of unknown function (DUF2496) HP433_RS17225 ENOG4105EGS Mechanosensitive ion channel HP433_RS17230 ENOG4107XI7 Tetr family transcriptional regulator HP433_RS17235 ENOG4105C1P efflux transporter, rnd family, mfp subunit HP433_RS17240 ENOG4105BZS acriflavin resistance protein HP433_RS17245 ENOG4108UKR Biofilm formation regulator YbaJ HP433_RS17250 ENOG4105KF5 hemolysin expression-modulating protein HP433_RS17255 ENOG4108UW5 maltose o-acetyltransferase HP433_RS17260 ENOG4105GSJ Inner membrane protein ylaC HP433_RS17265 ENOG41066DG (EAL) domain protein HP433_RS17270 ENOG4105KCV RNA signal recognition particle 4.5S RNA HP433_RS17280 ENOG41080UX Methyltransferase HP433_RS17285 ENOG4108MNP Glycoprotein polysaccharide metabolism HP433_RS17290 ENOG4105C29 acyl-CoA thioesterase HP433_RS17295 ENOG4105BZU Histidine kinase HP433_RS17300 ENOG4108YZA Nitrogen regulatory protein pii HP433_RS17305 ENOG4105BZ1 (ABC) transporter HP433_RS17310 ENOG4105BZ1 (ABC) transporter HP433_RS17315 ENOG4108XM1 transcriptional regulator AsnC family HP433_RS17325 ENOG4108NFA extracellular solute-binding protein HP433_RS17335 ENOG4108TGP Thioesterase superfamily protein HP433_RS17340 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HP433_RS17345 ENOG4105EIN peptidylprolyl cis-trans isomerase HP433_RS17350 ENOG4105K70 DNA-binding protein HP433_RS17355 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HP433_RS17375 ENOG4105M85 Bola protein HP433_RS17380 ENOG4105IEY (LipO)protein HP433_RS17385 ENOG4105EYM Major Facilitator superfamily HP433_RS17390 ENOG4105E2S oxidase) subunit II HP433_RS17395 ENOG4105BZ9 Cytochrome C oxidase, subunit I HP433_RS17400 ENOG4105CCU oxidase (Subunit III) HP433_RS17405 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HP433_RS17430 ENOG4107RDB Major Facilitator HP433_RS17440 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HP433_RS17445 ENOG4107S0N DJ-1 family HP433_RS17460 ENOG4105CTB Polyprenyl synthetase HP433_RS17470 ENOG4105CPC Aldo Keto reductase HP433_RS17475 ENOG4108ZAI phosphatidylglycerophosphatase a HP433_RS17480 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HP433_RS17490 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HP433_RS17495 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HP433_RS17505 ENOG4108KIC (LipO)protein HP433_RS17510 ENOG4105DRB nucleoside-specific channel-forming protein HP433_RS17515 ENOG4105N1F Hnh endonuclease HP433_RS17520 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HP433_RS17525 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HP433_RS17530 ENOG4105VIE preprotein translocase, subunit YajC HP433_RS17550 ENOG4107R28 alpha amylase, catalytic region HP433_RS17555 ENOG4105C85 amino acid HP433_RS17560 ENOG4105CWM branched-chain amino acid transport system II carrier protein HP433_RS17565 ENOG4105BZU Histidine kinase HP433_RS17570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HP433_RS17575 ENOG4107RH8 nuclease SbcCD subunit D HP433_RS17580 ENOG4105EYH Exonuclease HP433_RS17585 ENOG4105F27 Major Facilitator HP433_RS17590 ENOG4105DKQ ROK family HP433_RS17615 ENOG4105HBA AroM protein HP433_RS17620 ENOG4105SS3 HP433_RS17635 ENOG4105II7 pyrroline-5-carboxylate reductase HP433_RS17640 ENOG4105BZU Histidine kinase HP433_RS17645 ENOG4105VIF phosphate starvation-inducible protein HP433_RS17650 ENOG4105G6Z alkaline phosphatase HP433_RS17665 ENOG4105CPF Cell wall formation (By similarity) HP433_RS17670 ENOG4105UNH Membrane HP433_RS17675 ENOG4105FR5 inner membrane protein YaiY HP433_RS17680 ENOG4107QS8 (LipO)protein HP433_RS17685 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HP433_RS17690 ENOG4107R6D beta-lactam binding protein AmpH HP433_RS17695 ENOG4108PNB DNA-binding transcriptional regulator HP433_RS17705 ENOG4105D52 delta-aminolevulinic acid dehydratase HP433_RS17710 ENOG4105E2B Taurine dioxygenase HP433_RS17715 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HP433_RS17725 ENOG4106FTQ Taurine ABC transporter, periplasmic HP433_RS17730 ENOG4107W19 lmbE family HP433_RS17735 ENOG4108PBI Polysaccharide metabolism HP433_RS17745 ENOG4105SRB Uncharacterized protein yaiO HP433_RS17770 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HP433_RS17775 ENOG4108SC4 )-transporter HP433_RS17810 ENOG4108K2P TRANSCRIPTIONal HP433_RS17815 ENOG4105ETE Transcriptional regulator (LacI family HP433_RS17825 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HP433_RS17830 ENOG4108UW5 maltose o-acetyltransferase HP433_RS17835 ENOG4105DJ2 Major Facilitator Superfamily HP433_RS17845 ENOG4107B2H carbonic anhydrase HP433_RS17850 ENOG4105DND Transcriptional regulator HP433_RS17855 ENOG4105DZC cytosine deaminase HP433_RS17860 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HP433_RS17865 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HP433_RS17870 ENOG4105DXD 2-methylcitrate dehydratase HP433_RS17875 ENOG4105BZN citrate synthase HP433_RS17880 ENOG4105CR4 methylisocitrate lyase HP433_RS17885 ENOG4108JU7 Transcriptional regulator HP433_RS17890 ENOG4105TDT uncharacterized protein yahO HP433_RS17895 ENOG4105E82 cytochrome subunit of dehydrogenase HP433_RS17910 ENOG4105DQ4 alcohol dehydrogenase HP433_RS17915 ENOG4105CNN ABC, transporter HP433_RS17920 ENOG4105CNN ABC, transporter HP433_RS17925 ENOG4105C2J ABC transporter HP433_RS17930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HP433_RS17940 ENOG4105DZC cytosine deaminase HP433_RS17945 ENOG4105C5B carbamate kinase HP433_RS17950 ENOG4107REC cytoplasmic protein HP433_RS17955 ENOG4107R1Q Membrane protein FdrA HP433_RS17960 ENOG4105N16 Protein of unknown function (DUF2877) HP433_RS17965 ENOG4107SNB ankyrin repeat protein YahD HP433_RS17970 ENOG4105SZ2 membrAne HP433_RS17975 ENOG4108NUU Transcriptional regulator HP433_RS17980 ENOG4105BZU Histidine kinase HP433_RS17990 ENOG4105C94 Transporter HP433_RS18015 ENOG4108W9T type 1 fimbriae regulatory protein HP433_RS18020 ENOG4105BZU Histidine kinase HP433_RS18045 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HP433_RS18050 ENOG4107QR9 Iron-sulfur cluster binding protein HP433_RS18055 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HP433_RS18060 ENOG4108K01 transcriptional regulator HP433_RS18065 ENOG4107QN2 dihydrolipoyl dehydrogenase HP433_RS18070 ENOG41066GK UPF0379 protein ykgI HP433_RS18075 ENOG4108KBJ Inner membrane protein YkgB HP433_RS18080 ENOG4105CV8 reductase HP433_RS18175 ENOG4108KU3 Integrase HP433_RS18195 ENOG4105FCK Membrane HP433_RS18215 ENOG4105CIN aminoacyl-histidine dipeptidase HP433_RS18220 ENOG4108S2Y peptide Chain Release factor HP433_RS18230 ENOG4108HYG acetyltransferase HP433_RS18245 ENOG4107RD7 Flagellar Motor Protein, MotA HP433_RS18275 ENOG410804A Flagellar hook-associated 2 domain-containing protein HP433_RS18280 ENOG4105I03 Flagellin HP433_RS18295 ENOG4105DTJ flagellar hook-associated protein HP433_RS18305 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HP433_RS18320 ENOG4105CGA flagellar basal-body rod protein FlgG HP433_RS18325 ENOG4108KPB Flagellar basal-body rod protein FlgF HP433_RS18330 ENOG4105BZE flagellar hook protein, FlgE HP433_RS18340 ENOG4108ZC9 flagellar basal-body rod protein flgc HP433_RS18345 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HP433_RS18375 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HP433_RS18385 ENOG4108JIR Flagellum-specific ATP synthase HP433_RS18395 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HP433_RS18400 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HP433_RS18420 ENOG4105DD5 Flagellar motor switch protein HP433_RS18425 ENOG4105CN7 Flagellar biosynthetic protein FliP HP433_RS18430 ENOG4105VS8 Flagellar biosynthetic protein fliq HP433_RS18435 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HP433_RS18440 ENOG4105D00 flagellar biosynthetic protein flhB HP433_RS18460 ENOG4108YS0 lipoprotein YafL HP433_RS18470 ENOG4105VXN addiction module toxin, RelE StbE family HP433_RS18475 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HP433_RS18480 ENOG4105E7A Glutamine amidotransferase HP433_RS18490 ENOG4107QPN acyl-Coa dehydrogenase HP433_RS18495 ENOG4108WN0 inhibitor of vertebrate lysozyme HP433_RS18500 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HP433_RS18540 ENOG4105GMB type VI secretion system effector, hcp1 family HP433_RS18555 ENOG410600K aminopeptidase HP433_RS18565 ENOG4107RZZ dna polymerase iii epsilon subunit HP433_RS18575 ENOG4105D1A Methyltransferase HP433_RS18580 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HP433_RS18585 ENOG4105E9H Lytic Murein transglycosylase HP433_RS18590 ENOG4105F2W methyltransferase HP433_RS18600 ENOG4105HEI LysR family (Transcriptional regulator HP433_RS18605 ENOG4105CV8 reductase HP433_RS18640 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HP433_RS18645 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HP433_RS18650 ENOG4108UMI ABC transporter, permease HP433_RS18655 ENOG4105D01 (LipO)protein HP433_RS18660 ENOG4108R8X outer membrane lipoprotein HP433_RS18665 ENOG4108R96 Methyltransferase, YaeB family HP433_RS18680 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HP433_RS18685 ENOG4108YZN class I peptide chain release factor HP433_RS18690 ENOG4108VWS Yaeq family HP433_RS18700 ENOG4105M1T rho-binding antiterminator HP433_RS18705 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HP433_RS18710 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HP433_RS18715 ENOG4105CXN decarboxylase HP433_RS18725 ENOG4105C0B DNA polymerase III (alpha subunit) HP433_RS18750 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HP433_RS18755 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HP433_RS18765 ENOG4105DZP Membrane-associated zinc metalloprotease HP433_RS18770 ENOG4105KNE Phosphatidate cytidylyltransferase HP433_RS18775 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HP433_RS18780 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HP433_RS18805 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HP433_RS18825 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HP433_RS18830 ENOG4105C0H protease HP433_RS18845 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HP433_RS18850 ENOG4105EN6 Membrane HP433_RS18875 ENOG4105S6R Iron-hydroxamate transporter permease subunit HP433_RS18880 ENOG4105J76 Periplasmic binding protein HP433_RS18885 ENOG4105E0A ABC, transporter HP433_RS18890 ENOG4105E0K tonB-dependent siderophore receptor HP433_RS18895 ENOG4105BZ4 penicillin-binding protein HP433_RS18900 ENOG4105CQ7 ATP-dependent helicase HP433_RS18905 ENOG4107XID 2'-5' rna ligase HP433_RS18925 ENOG4105DJ0 Poly(A) Polymerase HP433_RS18930 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HP433_RS18940 ENOG4108VEV chaperone HP433_RS18945 ENOG4105CW0 outer membrane usher protein HP433_RS18950 ENOG4108XEY fimbrial-like adhesin protein HP433_RS18955 ENOG4105SYG Fimbrial protein HP433_RS18960 ENOG4105SN2 fimbrial-like adhesin protein HP433_RS18965 ENOG4105P0Q fimbrial-like protein YadC HP433_RS18980 ENOG4108A32 Transposase HP433_RS18990 ENOG4107BJW polysaccharide deacetylase HP433_RS18995 ENOG4108YTN IIa component HP433_RS19000 ENOG4105E3A (ABC) transporter HP433_RS19005 ENOG4105DA5 (ABC) transporter HP433_RS19010 ENOG41077A9 carbonic anhydrase HP433_RS19015 ENOG4108UGV hypoxanthine phosphoribosyltransferase HP433_RS19020 ENOG4105DZG Dehydrogenase HP433_RS19025 ENOG4105E3B Multicopper oxidase HP433_RS19030 ENOG4108ZRK uncharacterized protein yacC HP433_RS19050 ENOG4107QIJ Aconitate hydratase 2 HP433_RS19055 ENOG4108NST exported protein HP433_RS19060 ENOG4107QN2 dihydrolipoyl dehydrogenase HP433_RS19065 ENOG4107QSN dihydrolipoamide acetyltransferase HP433_RS19070 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HP433_RS19075 ENOG41073TP transcriptional regulator HP433_RS19080 ENOG4105C85 amino acid HP433_RS19085 ENOG4106A72 regulatory protein AmpE HP433_RS19090 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HP433_RS19095 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HP433_RS19100 ENOG4108ZUW Major pilin subunit HP433_RS19105 ENOG4107QHF type ii secretion system protein e HP433_RS19110 ENOG4105D7Q type ii secretion system HP433_RS19120 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HP433_RS19135 ENOG4105M6F mutator MutT protein HP433_RS19145 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HP433_RS19155 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HP433_RS19160 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HP433_RS19165 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HP433_RS19170 ENOG4105CPF Cell wall formation (By similarity) HP433_RS19185 ENOG4105CNI cell division protein FtsW HP433_RS19200 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HP433_RS19205 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HP433_RS19210 ENOG4105CJN penicillin-binding protein HP433_RS19215 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HP433_RS19230 ENOG4107B7Y DNA-binding transcriptional regulator FruR HP433_RS19240 ENOG4108ZP8 Acetolactate synthase small subunit HP433_RS19245 ENOG4105C7K acetolactate synthase HP433_RS19250 ENOG41064T2 transcriptional regulator, lysR family HP433_RS19265 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HP433_RS19280 ENOG4105S8Q sugar efflux transporter HP433_RS19295 ENOG4105DP9 ABC transporter HP433_RS19300 ENOG4106SMU thiamine transporter membrane protein HP433_RS19310 ENOG4108KF1 Membrane HP433_RS19315 ENOG41063TF transcriptional regulator (AraC HP433_RS19320 ENOG4105EF1 ribulokinase HP433_RS19330 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HP433_RS19335 ENOG4105CQ2 DNA polymerase HP433_RS19340 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HP433_RS19345 ENOG4105D3G Pseudouridine synthase HP433_RS19350 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HP433_RS19355 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HP433_RS19360 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HP433_RS19385 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HP433_RS19400 ENOG4105C54 Major Facilitator superfamily HP433_RS19405 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HP433_RS19410 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HP433_RS19445 ENOG4106YT9 Enoyl-CoA hydratase HP433_RS19455 ENOG4108XNW Transcriptional activatory protein CaiF HP433_RS19460 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HP433_RS19465 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HP433_RS19485 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HP433_RS19495 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HP433_RS19500 ENOG4105DTN riboflavin biosynthesis protein ribF HP433_RS19505 ENOG410647N response to DNA damage stimulus HP433_RS19530 ENOG41063Z6 transcriptional regulator, lysR family HP433_RS19540 ENOG4105WI6 cell killing protein encoded within cryptic prophage HP433_RS19560 ENOG4108QUJ UPF0174 protein YaaW HP433_RS19565 ENOG4106HK8 GPR1 FUN34 yaaH family protein HP433_RS19570 ENOG4108RIR Molybdenum cofactor biosynthesis protein HP433_RS19580 ENOG4105BZG amino acid carrier protein HP433_RS19590 ENOG41062C6 Protein of unknown function (DUF2502) HP433_RS19595 ENOG4105D98 threonine synthase HP433_RS19605 ENOG4105CFH Aspartokinase HP433_RS19615 ENOG4106FVC RNA methyltransferase HP433_RS19620 ENOG410759A HP433_RS19625 ENOG41065U4 response regulator HP433_RS19630 ENOG4105CT7 inner membrane cred family protein HP433_RS19635 ENOG4105EB3 Histidine kinase HP433_RS19640 ENOG4105E3W Two component transcriptional regulator (Winged helix family HP433_RS19645 ENOG4108RH0 Crea protein HP433_RS19650 ENOG4105UEI Transcriptional Regulator AraC Family HP433_RS19660 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HP433_RS19670 ENOG4107SC1 transglycosylase HP433_RS19675 ENOG4105C5H ABC transporter HP433_RS19680 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HP433_RS19685 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HP433_RS19690 ENOG4105EAC phosphoserine phosphatase HP433_RS19695 ENOG41062Z9 Membrane HP433_RS19730 ENOG4105G0K glycine radical enzyme YjjI family HP433_RS19735 ENOG41076CZ activating enzyme HP433_RS19740 ENOG4105EYA deoxyribonuclease HP433_RS19745 ENOG4108NRW Phospholipase, patatin family HP433_RS19755 ENOG4105K3G Periplasmic Protein HP433_RS19765 ENOG4105PAD Hydrolase HP433_RS19770 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HP433_RS19775 ENOG4108WPU DNA polymerase III subunit psi HP433_RS19800 ENOG4105YBH Protein of unknown function (DUF1435) HP433_RS19805 ENOG4108819 ferric iron reductase HP433_RS19810 ENOG4108T94 DNA-binding transcriptional activator BglJ HP433_RS19815 ENOG4108N8T regulatoR HP433_RS19820 ENOG4105DWK Membrane HP433_RS19835 ENOG4106CVF DNA replication protein HP433_RS19840 ENOG4105RI1 glycoprotein receptor HP433_RS19850 ENOG4105CPQ Dehydrogenase HP433_RS19855 ENOG410617M Transcriptional regulator HP433_RS19860 ENOG4108I5G Major Facilitator superfamily HP433_RS19865 ENOG4105C8Q Methyl-accepting chemotaxis HP433_RS19870 ENOG4108V8F Transcriptional regulator, MarR family HP433_RS19875 ENOG4105ERH Fumarylacetoacetate hydrolase HP433_RS19880 ENOG4105C26 Dehydrogenase HP433_RS19885 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HP433_RS19915 ENOG4105EFA 4-hydroxyphenylacetate HP433_RS19920 ENOG4107UWN reductase HP433_RS19925 ENOG4105D22 carbon starvation protein HP433_RS19930 ENOG4105VCD cytoplasmic protein HP433_RS19935 ENOG4105CKI cobalamin synthesis protein HP433_RS19950 ENOG4108F3G Type I restriction-modification system, R subunit HP433_RS19960 ENOG4107QTH restriction modification system DNA specificity domain HP433_RS19980 ENOG4106DIZ Domain of unknown function (DUF1127) HP433_RS19985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HP433_RS20000 ENOG41083G8 Multidrug resistance protein MdtM HP433_RS20005 ENOG4106BRA Membrane HP433_RS20010 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HP433_RS20015 ENOG4105CIZ coA-substrate-specific enzyme activase HP433_RS20030 ENOG4105CBP Major Facilitator HP433_RS20040 ENOG41074DU domain protein HP433_RS20045 ENOG4108P2H Inner membrane protein YjiG HP433_RS20050 ENOG4105DYB Isoaspartyl dipeptidase HP433_RS20055 ENOG4107YNJ LysR family Transcriptional regulator HP433_RS20075 ENOG4105C6F GntR Family Transcriptional Regulator HP433_RS20080 ENOG4105DEI Mannitol dehydrogenase HP433_RS20090 ENOG4107EFN gluconate transport system permease 3 HP433_RS20095 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HP433_RS20100 ENOG4108T65 Fimbrial HP433_RS20105 ENOG4108SQA Fimbrial HP433_RS20110 ENOG4105CW0 outer membrane usher protein HP433_RS20115 ENOG4108NAE Fimbrial chaperone protein HP433_RS20120 ENOG4108S54 Fimbrial protein HP433_RS20125 ENOG4108RQP Major type 1 subunit fimbrin HP433_RS20130 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HP433_RS20135 ENOG4108W9T type 1 fimbriae regulatory protein HP433_RS20140 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HP433_RS20165 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HP433_RS20185 ENOG4105DQ4 alcohol dehydrogenase HP433_RS20190 ENOG4105D7A ATP-binding protein HP433_RS20195 ENOG4108K5H permease YjgP YjgQ family protein HP433_RS20200 ENOG4108M8S permease YjgP YjgQ family protein HP433_RS20210 ENOG4105MYG DNA polymerase iii, chi subunit HP433_RS20215 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HP433_RS20220 ENOG4108M3P Membrane HP433_RS20225 ENOG4108MJ3 acetyltransferase HP433_RS20230 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HP433_RS20250 ENOG4105XEP YhcH YjgK YiaL family protein HP433_RS20255 ENOG4108XFH Transcriptional regulator HP433_RS20265 ENOG4105F9F transposase HP433_RS20275 ENOG4108UQ8 endoribonuclease L-psp HP433_RS20280 ENOG4107C93 pyrBI operon leader peptide HP433_RS20295 ENOG4105KME endoribonuclease L-psp HP433_RS20300 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HP433_RS20310 ENOG4105D4X repressor HP433_RS20315 ENOG4105C5Y PTS System HP433_RS20320 ENOG4105CG3 alpha amylase, catalytic region HP433_RS20325 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HP433_RS20330 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HP433_RS20340 ENOG4105CMS peptidase U62, modulator of DNA gyrase HP433_RS20350 ENOG4105DFU Cell wall formation (By similarity) HP433_RS20360 ENOG41062B0 ABC transporter, permease HP433_RS20365 ENOG4107R9N ABC transporter HP433_RS20370 ENOG4105C2J ABC transporter HP433_RS20375 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HP433_RS20380 ENOG4105F0N pyrophosphate phospho-hydrolase HP433_RS20385 ENOG4105MZG transcriptional modulator of maze toxin, mazf HP433_RS20390 ENOG41087RY SpoVT_AbrB HP433_RS20395 ENOG4108ZHD aig2 family HP433_RS20400 ENOG4105MA0 exported protein HP433_RS20405 ENOG4105CFU surface antigen HP433_RS20415 ENOG4105C37 (CBS) domain HP433_RS20420 ENOG41061GZ Protein of unknown function (DUF1107) HP433_RS20425 ENOG4108UUE Transcriptional regulator HP433_RS20430 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HP433_RS20435 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HP433_RS20440 ENOG4105KVH Transcriptional regulator HP433_RS20445 ENOG4105ECR NmrA family HP433_RS20450 ENOG4105DXC membrane HP433_RS20460 ENOG4105C85 amino acid HP433_RS20465 ENOG4108V1T peptidylprolyl cis-trans isomerase HP433_RS20470 ENOG4105FHY Opacity-associated protein A HP433_RS20480 ENOG4105CHR reductase HP433_RS20490 ENOG4105E39 Enoyl-CoA hydratase HP433_RS20495 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HP433_RS20500 ENOG4107S3R L-aspartate oxidase HP433_RS20505 ENOG41069H7 transport system small permease component HP433_RS20510 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HP433_RS20515 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HP433_RS20525 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HP433_RS20540 ENOG4105KIT UPF0379 protein yjfY HP433_RS20570 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HP433_RS20585 ENOG4108MXZ Esterase HP433_RS20590 ENOG4105WSB biofilm stress and motility protein A HP433_RS20595 ENOG4105S17 UPF0379 protein yjfN HP433_RS20600 ENOG4105CSU acyl-Coa dehydrogenase HP433_RS20605 ENOG4106032 Glutathionylspermidine synthase HP433_RS20610 ENOG4108KXT Conserved Protein HP433_RS20615 ENOG4105Z6B inner membrane protein yjfl HP433_RS20620 ENOG4107VNS Protein of unknown function (DUF2491) HP433_RS20625 ENOG4108P9J Phage shock protein A HP433_RS20630 ENOG4105FUX Conserved Protein HP433_RS20635 ENOG4105C2N RNA methyltransferase TrmH family group 3 HP433_RS20640 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HP433_RS20660 ENOG4105EPW hflc protein HP433_RS20665 ENOG4107QJR hflk protein HP433_RS20670 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HP433_RS20690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HP433_RS20695 ENOG4105K8N protein family UPF0079, ATPase HP433_RS20700 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HP433_RS20705 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HP433_RS20745 ENOG4105EGS Mechanosensitive ion channel HP433_RS20750 ENOG4106CG8 Inner membrane protein YjeO HP433_RS20755 ENOG4106V5W HP433_RS20760 ENOG4107SC7 Inner membrane transporter yjeM HP433_RS20770 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HP433_RS20775 ENOG4105E33 succinate dehydrogenase HP433_RS20790 ENOG41066YJ Beta-lactamase HP433_RS20795 ENOG4105QNF Outer membrane lipoprotein HP433_RS20800 ENOG4105KPY Small multidrug resistance protein HP433_RS20805 ENOG4106BSU Entericidin B HP433_RS20810 ENOG4107PEH Entericidin EcnA/B family HP433_RS20820 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HP433_RS20825 ENOG4105MTB Uncharacterized protein YjeJ HP433_RS20830 ENOG4108ZVF (LipO)protein HP433_RS20845 ENOG4105DVH amino acid HP433_RS20850 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HP433_RS20855 ENOG4108IJ0 Aspartate ammonia-lyase HP433_RS20860 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HP433_RS20875 ENOG4108SIC Transcriptional regulator HP433_RS20885 ENOG4108M3R transcriptional activator CadC HP433_RS20890 ENOG4105D5Q Arginine ornithine antiporter HP433_RS20895 ENOG4105CXN decarboxylase HP433_RS20900 ENOG4105DUX Transporter HP433_RS20905 ENOG4105CRK lysyL-tRNA synthetase HP433_RS20920 ENOG410830R acetyltransferase HP433_RS20925 ENOG4105VR1 Pfam:DUF1271 HP433_RS20930 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HP433_RS20935 ENOG4108MRH transcriptional regulatory protein HP433_RS20940 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HP433_RS20945 ENOG4107GFK fumarate HP433_RS20950 ENOG4108R5S membrane HP433_RS20955 ENOG4105CT4 transporter HP433_RS20960 ENOG4105F8D glycoside hydrolase family 4 HP433_RS20965 ENOG4108K2B transcriptional regulator HP433_RS20970 ENOG4105CXN decarboxylase HP433_RS20975 ENOG4106ZGR Transcriptional regulator HP433_RS20980 ENOG4105D5Q Arginine ornithine antiporter HP433_RS20985 ENOG4105DIJ Phosphoethanolamine transferase HP433_RS20990 ENOG4105XJC Two component transcriptional regulator (Winged helix family HP433_RS20995 ENOG4105ECM Sensor protein basS pmrB HP433_RS21005 ENOG4105CSH Transporter HP433_RS21010 ENOG4108YIV HP433_RS21015 ENOG4108F5E vimentin HP433_RS21020 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HP433_RS21025 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HP433_RS21030 ENOG4105D5T phosphonate abc transporter HP433_RS21035 ENOG4105EHI Phosphonate ABC transporter, periplasmic HP433_RS21045 ENOG4107RJJ Transcriptional regulator HP433_RS21050 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HP433_RS21055 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HP433_RS21060 ENOG4105EKV Phosphonate metabolism protein HP433_RS21065 ENOG4105FT8 Phosphonate metabolism HP433_RS21070 ENOG4105ENV phosphonate C-P lyase system protein PhnK HP433_RS21075 ENOG4105HRV phosphonate c-p lyase system protein phnl HP433_RS21080 ENOG4105FD8 phosphonate metabolism protein PhnM HP433_RS21085 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HP433_RS21090 ENOG410849A acetyltransferase, (GNAT) family HP433_RS21095 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HP433_RS21105 ENOG4108YZG isomerase HP433_RS21110 ENOG4105EUZ Beta-lactamase domain protein HP433_RS21120 ENOG4105J12 Multidrug resistance protein mdtN HP433_RS21125 ENOG4108MI0 Resistance protein HP433_RS21130 ENOG4105ETP RND efflux system, outer membrane lipoprotein HP433_RS21140 ENOG41082ND Uncharacterized protein yjcO HP433_RS21145 ENOG4105CK2 sodium dicarboxylate symporter HP433_RS21150 ENOG4108W0S formate-dependent nitrite reductase complex HP433_RS21160 ENOG4108QKW cytochrome c-type biogenesis protein HP433_RS21165 ENOG4105DVI reductase, NrfD HP433_RS21170 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP433_RS21175 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HP433_RS21185 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HP433_RS21190 ENOG41062QD Membrane HP433_RS21205 ENOG4105EEQ Na H antiporter HP433_RS21210 ENOG4105C7N Xanthine uracil vitamin C permease HP433_RS21215 ENOG4108Z4X TRANSCRIPTIONal HP433_RS21220 ENOG4108W3Q Transcriptional regulator HP433_RS21225 ENOG4108M8H domain protein HP433_RS21230 ENOG4105PMV Membrane HP433_RS21235 ENOG4108UUM single-stranded DNA-binding protein HP433_RS21240 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HP433_RS21245 ENOG4105MSB protein, conserved in bacteria HP433_RS21250 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HP433_RS21255 ENOG4105F0S class B acid phosphatase HP433_RS21265 ENOG4105CGF Aromatic amino acid aminotransferase HP433_RS21270 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HP433_RS21275 ENOG4105CDU Replicative dna helicase HP433_RS21280 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HP433_RS21285 ENOG4105P4Z Phage shock protein G HP433_RS21290 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HP433_RS21300 ENOG4105MYN Zinc uptake regulation protein HP433_RS21305 ENOG4105VDW Csbd family HP433_RS21310 ENOG4107R73 Mate efflux family protein HP433_RS21320 ENOG41080IJ Diacylglycerol kinase HP433_RS21345 ENOG4107W52 maltose operon periplasmic protein HP433_RS21355 ENOG4108IJ9 (ABC) transporter HP433_RS21360 ENOG4107FKK extracellular solute-binding protein family 1 HP433_RS21365 ENOG4105D56 permease protein HP433_RS21370 ENOG4105EG2 ABC transporter, permease HP433_RS21375 ENOG4107QNK )-transporter HP433_RS21390 ENOG4105E3R (LipO)protein HP433_RS21395 ENOG4108Q9C Periplasmic Protein HP433_RS21400 ENOG4108MDC (LipO)protein HP433_RS21410 ENOG4107QP8 phosphohexose isomerase HP433_RS21415 ENOG4105CFH Aspartokinase HP433_RS21420 ENOG4108WZA zeta toxin HP433_RS21425 ENOG410756H nucleotidyltransferase HP433_RS21435 ENOG4108ZR5 Conserved Protein HP433_RS21440 ENOG4105FE9 pseudouridine synthase HP433_RS21450 ENOG4105EAM Na Pi-cotransporter HP433_RS21455 ENOG4105C3R Methionine synthase HP433_RS21460 ENOG41069M3 Transcriptional regulator HP433_RS21475 ENOG4108I9X Isocitrate lyase HP433_RS21480 ENOG4107QP3 malate synthase g HP433_RS21490 ENOG4105K5X acetyltransferase HP433_RS21520 ENOG4105C12 Phosphoribosylglycinamide synthetase HP433_RS21525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HP433_RS21530 ENOG4105BZU Histidine kinase HP433_RS21535 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HP433_RS21540 ENOG4108T8B Protein of unknown function (DUF1481) HP433_RS21550 ENOG4105R2J Conserved Protein HP433_RS21575 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HP433_RS21585 ENOG4105D06 uba thif-type nad fad binding protein HP433_RS21590 ENOG4105WHD thiamine biosynthesis protein ThiS HP433_RS21600 ENOG4105D41 biosynthesis protein thiH HP433_RS21605 ENOG410645W Thiamin biosynthesis protein ThiH HP433_RS21640 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HP433_RS21645 ENOG4105PM1 preprotein translocase subunit SecE HP433_RS21680 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HP433_RS21725 ENOG4108Y73 Membrane HP433_RS21730 ENOG4105EJ2 Transcriptional regulator HP433_RS21740 ENOG4105C5Q Transcriptional regulator HP433_RS21745 ENOG4108I5G Major Facilitator superfamily HP433_RS21750 ENOG4105CXK mandelate racemase muconate lactonizing HP433_RS21765 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HP433_RS21780 ENOG4105DIJ Phosphoethanolamine transferase HP433_RS21785 ENOG4106R3P AraC family transcriptional regulator HP433_RS21790 ENOG4108XCZ PTS System HP433_RS21795 ENOG4108AHH pyruvate formate lyase II activase HP433_RS21805 ENOG4108YRF PTS System HP433_RS21810 ENOG4105DM4 PTS System HP433_RS21815 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HP433_RS21820 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HP433_RS21825 ENOG4105DCT glycerol dehydrogenase HP433_RS21830 ENOG4108XC3 NADH ubiquinone oxidoreductase HP433_RS21835 ENOG4108Q5Y Membrane HP433_RS21845 ENOG4105SYT Methylenetetrahydrofolate reductase HP433_RS21850 ENOG4105CFH Aspartokinase HP433_RS21855 ENOG4105C28 cystathionine HP433_RS21865 ENOG4107S01 Repressor protein MetJ HP433_RS21880 ENOG4105CNA YD repeat protein HP433_RS21890 ENOG4105C25 Primosomal protein n' HP433_RS21895 ENOG4105ETE Transcriptional regulator (LacI family HP433_RS21900 ENOG41063M6 Cell Division Protein HP433_RS21915 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HP433_RS21930 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HP433_RS21940 ENOG4105CBT Fructose-1,6-bisphosphatase HP433_RS21945 ENOG4105DP0 ferredoxin-NADP reductase HP433_RS21955 ENOG41065TG regulatoR HP433_RS21960 ENOG4108VTS Membrane HP433_RS21965 ENOG4105EBK exported protein HP433_RS21980 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HP433_RS21995 ENOG4105FMW periplasmic HP433_RS22000 ENOG4105E3W Two component transcriptional regulator (Winged helix family HP433_RS22005 ENOG4105E0F Histidine kinase HP433_RS22010 ENOG4108RPX mosc domain containing protein HP433_RS22020 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HP433_RS22060 ENOG41064BA PTS system, fructose-specific, IIA component HP433_RS22065 ENOG4105DM4 PTS System HP433_RS22070 ENOG4105CN9 Peptidase m42 family protein HP433_RS22075 ENOG4106C3V frv operon regulatory protein HP433_RS22090 ENOG4108V87 frv operon regulatory protein HP433_RS22105 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HP433_RS22110 ENOG4108MG3 formate dehydrogenase HP433_RS22120 ENOG41068KX affects formate dehydrogenase-N HP433_RS22135 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HP433_RS22145 ENOG4105SUU thioesterase domain HP433_RS22160 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HP433_RS22170 ENOG4105CSH Transporter HP433_RS22180 ENOG4105CPQ Dehydrogenase HP433_RS22185 ENOG4105D2M Aldolase HP433_RS22190 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HP433_RS22195 ENOG4108MGF sugar kinase HP433_RS22200 ENOG4105E98 transcriptional regulator DeoR family HP433_RS22205 ENOG4105R9B Major Facilitator HP433_RS22210 ENOG4108KHF Resistance protein HP433_RS22215 ENOG4108K85 Transcriptional regulator HP433_RS22220 ENOG4105CI3 gtp-binding protein typa HP433_RS22225 ENOG4105C5F glutamine synthetase HP433_RS22230 ENOG4105CUX Signal transduction histidine kinase HP433_RS22235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HP433_RS22240 ENOG4106FIY HP433_RS22245 ENOG4105D4P Coproporphyrinogen iii oxidase HP433_RS22260 ENOG4105C2M dna polymerase I HP433_RS22265 ENOG4106HNH Acyl-transferase HP433_RS22275 ENOG4108Z33 Thiol disulfide Interchange Protein HP433_RS22280 ENOG4105E27 serine threonine protein kinase HP433_RS22285 ENOG4105PC1 Conserved Protein HP433_RS22290 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HP433_RS22295 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HP433_RS22325 ENOG4108RR8 protoporphyrinogen oxidase HP433_RS22330 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HP433_RS22335 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HP433_RS22355 ENOG4108EX3 reductase HP433_RS22360 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HP433_RS22365 ENOG4105MDZ Transcriptional activator rfaH HP433_RS22375 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HP433_RS22380 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HP433_RS22385 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HP433_RS22395 ENOG4105JC1 sterol-binding domain protein HP433_RS22405 ENOG4105CGY Dna recombination protein HP433_RS22410 ENOG4108I5U Uridine phosphorylase HP433_RS22415 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HP433_RS22425 ENOG4105DZ2 Transcriptional regulator HP433_RS22430 ENOG4105EMK carboxylate amino acid amine transporter HP433_RS22435 ENOG4105DQF Hydrolase HP433_RS22440 ENOG4108EUD Lysophospholipase HP433_RS22445 ENOG410829K Lysine exporter protein (Lyse ygga) HP433_RS22450 ENOG4105CCF Lysine exporter protein (Lyse ygga) HP433_RS22455 ENOG4105C9U ATP-dependent DNA helicase RecQ HP433_RS22460 ENOG4105HDD phospholipase HP433_RS22465 ENOG4108VUY thioesterase Superfamily protein HP433_RS22470 ENOG4105FR1 rard protein HP433_RS22480 ENOG4107QUT magnesium and cobalt transport protein CorA HP433_RS22495 ENOG4107QUT magnesium and cobalt transport protein CorA HP433_RS22500 ENOG4108T58 Mg2 transport protein CorA HP433_RS22505 ENOG4105C4R Atp-dependent dna helicase HP433_RS22510 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HP433_RS22520 ENOG4105CT0 Protein of unknown function, DUF484 HP433_RS22530 ENOG4105S7Z (LipO)protein HP433_RS22540 ENOG4107T0K Adenylate cyclase HP433_RS22550 ENOG41076E6 Uroporphyrinogen-III Synthase HP433_RS22555 ENOG4105ECF c-methyltransferase HP433_RS22560 ENOG410601J HemY protein HP433_RS22565 ENOG4105ENH Sulfatase HP433_RS22570 ENOG4105C4X radical SAM domain protein HP433_RS22595 ENOG4105C85 amino acid HP433_RS22615 ENOG4105EGZ biosynthesis protein HP433_RS22620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HP433_RS22625 ENOG4108WJ1 acetyltransferase HP433_RS22630 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HP433_RS22635 ENOG4105C1B dTDP-glucose 4-6-dehydratase HP433_RS22640 ENOG4107QQG Dehydrogenase HP433_RS22645 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HP433_RS22650 ENOG4105SFE lipopolysaccharide biosynthesis protein HP433_RS22655 ENOG4105ESV Glycosyl transferase, family 4 HP433_RS22660 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HP433_RS22685 ENOG4105C4R Atp-dependent dna helicase HP433_RS22695 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HP433_RS22705 ENOG4105EMY transcriptional regulator HP433_RS22710 ENOG4105C7B Threonine dehydratase HP433_RS22720 ENOG4105CM2 brancheD-chain amino acid aminotransferase HP433_RS22725 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HP433_RS22745 ENOG4105C0P Mg chelatase subunit ChlI HP433_RS22750 ENOG4108WFC UPF0438 protein yifE HP433_RS22790 ENOG4107EJG GntR family transcriptional regulator HP433_RS22795 ENOG4105C0R drug resistance transporter emrb qaca subfamily HP433_RS22800 ENOG4105ETE Transcriptional regulator (LacI family HP433_RS22805 ENOG4108RVA ribokinase HP433_RS22810 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HP433_RS22815 ENOG4105CNN ABC, transporter HP433_RS22820 ENOG4105C2J ABC transporter HP433_RS22850 ENOG4108VVK transcriptional Regulator, AsnC HP433_RS22855 ENOG4105QTB Flavodoxin HP433_RS22870 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HP433_RS22920 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HP433_RS22945 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HP433_RS22950 ENOG4105C8U phosphate abc transporter HP433_RS22955 ENOG4105E2Z phosphate ABC transporter (Permease HP433_RS22960 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HP433_RS22965 ENOG4108UTW Plays a role in the regulation of phosphate uptake HP433_RS22970 ENOG4105CID antiterminator HP433_RS22975 ENOG4105C5Y PTS System HP433_RS22980 ENOG4105CS2 ec 3.2.1.21 HP433_RS22990 ENOG4105DYC esterase HP433_RS22995 ENOG4107VKM 6-phosphogluconolactonase HP433_RS23000 ENOG4106611 bacteriocin immunity HP433_RS23010 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HP433_RS23015 ENOG4105C7N Xanthine uracil vitamin C permease HP433_RS23020 ENOG4108YYH Nadph-dependent fmn reductase HP433_RS23025 ENOG4105E8Q phosphopantetheinyl transferase HP433_RS23040 ENOG4108P6C Tryptophan transporter of low affinity HP433_RS23055 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HP433_RS23075 ENOG4105VG0 50S ribosomal protein l34 HP433_RS23085 ENOG4106JVB Replication Protein HP433_RS23200 ENOG4108BUD transposase HP433_RS23235 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HP433_RS23290 ENOG4108KTG Membrane protein, drug metabolite transporter HP433_RS23330 ENOG4105EMU Dehydrogenase HP433_RS23380 ENOG4105I1F Resistance protein HP433_RS23425 ENOG4106CQM replication HP433_RS23495 ENOG41074AV Hok/gef family HP433_RS23575 ENOG4107QN2 dihydrolipoyl dehydrogenase HP433_RS23630 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HP433_RS23670 ENOG4106CQM replication HP433_RS23705 ENOG4108BUD transposase HP433_RS23790 ENOG4107QMH DNA methylase HP433_RS23795 ENOG4107J0C type IIi HP433_RS23820 ENOG4105DIJ Phosphoethanolamine transferase HP433_RS23825 ENOG41080IJ Diacylglycerol kinase HP433_RS23865 ENOG4105ESI atpase involved in dna repair HP433_RS23910 ENOG4106JQ7 HP433_RS23995 ENOG41074AV Hok/gef family HP433_RS24075 ENOG4107CBI conjugal transfer fertility inhibition protein HP433_RS24090 ENOG4105KK6 nuclease HP433_RS24105 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HP433_RS24160 ENOG4107QJE Chromosome Partitioning Protein HP433_RS24205 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HP433_RS24310 ENOG4108EHY type IV secretion system HP433_RS24335 ENOG4105KK6 nuclease HP433_RS24340 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HP433_RS24345 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HP433_RS24350 ENOG4108X73 DNA- binding protein HP433_RS24445 ENOG4105PGM cation diffusion facilitator family transporter