locus-tag	class	description
Eco28_RS00010	COG0592	DNA-directed DNA polymerase activity
Eco28_RS00020	COG0187	DNA topoisomerase II activity
Eco28_RS00025	COG3753	Protein conserved in bacteria
Eco28_RS00030	COG0561	phosphatase activity
Eco28_RS00045	COG0823	Involved in the tonB-independent uptake of proteins
Eco28_RS00050	COG5645	(Lipo)protein
Eco28_RS00070	COG2188	Transcriptional regulator
Eco28_RS00085	COG2207	Transcriptional regulator
Eco28_RS00090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Eco28_RS00095	COG3119	arylsulfatase activity
Eco28_RS00105	COG2149	membrane
Eco28_RS00115	COG0641	radical SAM
Eco28_RS00120	COG2814	Major facilitator Superfamily
Eco28_RS00150	COG0028	Belongs to the TPP enzyme family
Eco28_RS00155	COG0440	acetolactate synthase activity
Eco28_RS00180	COG2197	response regulator
Eco28_RS00185	COG3851	Histidine kinase
Eco28_RS00190	COG2271	Major facilitator Superfamily
Eco28_RS00195	COG2271	Major facilitator Superfamily
Eco28_RS00205	COG2252	PERMEase
Eco28_RS00235	COG1470	cell adhesion involved in biofilm formation
Eco28_RS00235	COG1388	LysM domain
Eco28_RS00240	COG1470	cell adhesion involved in biofilm formation
Eco28_RS00240	COG1388	LysM domain
Eco28_RS00280	COG0457	Tetratricopeptide repeat
Eco28_RS00290	COG1464	Belongs to the NlpA lipoprotein family
Eco28_RS00295	COG0697	spore germination
Eco28_RS00300	COG2814	Major facilitator Superfamily
Eco28_RS00315	COG2211	Major facilitator Superfamily
Eco28_RS00320	COG1501	Belongs to the glycosyl hydrolase 31 family
Eco28_RS00325	COG2982	Protein involved in outer membrane biogenesis
Eco28_RS00330	COG2233	PERMEase
Eco28_RS00335	COG0786	glutamate:sodium symporter activity
Eco28_RS00340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Eco28_RS00345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Eco28_RS00350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Eco28_RS00360	COG0194	GDP metabolic process
Eco28_RS00370	COG2860	membrane
Eco28_RS00375	COG3645	SOS response
Eco28_RS00380	COG1561	YicC-like family, N-terminal region
Eco28_RS00410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Eco28_RS00440	COG1519	Transferase
Eco28_RS00445	COG0859	PFAM glycosyl transferase family 9
Eco28_RS00450	COG0438	transferase activity, transferring glycosyl groups
Eco28_RS00455	COG0515	serine threonine protein kinase
Eco28_RS00470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Eco28_RS00475	COG1442	glycosyl transferase family 8
Eco28_RS00485	COG3307	-O-antigen
Eco28_RS00490	COG0859	PFAM glycosyl transferase family 9
Eco28_RS00495	COG0859	PFAM glycosyl transferase family 9
Eco28_RS00505	COG0156	8-amino-7-oxononanoate synthase activity
Eco28_RS00515	COG1216	Glycosyl transferase, family 2
Eco28_RS00520	COG2861	carbohydrate metabolic process
Eco28_RS00525	COG4942	peptidase
Eco28_RS00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Eco28_RS00545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Eco28_RS00560	COG1045	serine acetyltransferase
Eco28_RS00565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Eco28_RS00575	COG2186	Transcriptional regulator
Eco28_RS00580	COG1620	l-lactate permease
Eco28_RS00610	COG3722	fumarate hydratase activity
Eco28_RS00620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS00620	COG2213	PTS system mannitol-specific
Eco28_RS00630	COG1566	PFAM secretion protein HlyD family protein
Eco28_RS00640	COG3209	COG3209 Rhs family protein
Eco28_RS00655	COG3209	COG3209 Rhs family protein
Eco28_RS00660	COG0625	glutathione transferase activity
Eco28_RS00670	COG3276	selenocysteine insertion sequence binding
Eco28_RS00675	COG1454	alcohol dehydrogenase
Eco28_RS00685	COG1454	alcohol dehydrogenase
Eco28_RS00695	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS00710	COG1566	PFAM secretion protein HlyD family protein
Eco28_RS00715	COG0583	DNA-binding transcription factor activity
Eco28_RS00720	COG3713	MltA-interacting MipA family protein
Eco28_RS00730	COG2211	Major facilitator Superfamily
Eco28_RS00740	COG1414	Transcriptional regulator
Eco28_RS00745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS00750	COG3977	Valine--pyruvate aminotransferase
Eco28_RS00755	COG0366	Alpha amylase catalytic
Eco28_RS00760	COG2992	FlgJ-related protein
Eco28_RS00765	COG2207	Transcriptional regulator
Eco28_RS00765	COG1609	Transcriptional regulator
Eco28_RS00770	COG4214	carbohydrate transport
Eco28_RS00780	COG4213	ABC transporter substrate-binding protein
Eco28_RS00790	COG1070	Carbohydrate kinase
Eco28_RS00795	COG4682	membrane
Eco28_RS00800	COG4682	membrane
Eco28_RS00805	COG3274	enterobacterial common antigen metabolic process
Eco28_RS00830	COG1278	Cold shock
Eco28_RS00835	COG2944	sequence-specific DNA binding
Eco28_RS00850	COG2885	chlorophyll binding
Eco28_RS00855	COG0243	molybdopterin cofactor binding
Eco28_RS00860	COG0456	acetyltransferase
Eco28_RS00865	COG2818	Glycosylase
Eco28_RS00870	COG5571	outer membrane autotransporter
Eco28_RS00880	COG2223	nitrite transmembrane transporter activity
Eco28_RS00885	COG3539	Fimbrial protein
Eco28_RS00890	COG3121	Chaperone
Eco28_RS00900	COG3539	Fimbrial protein
Eco28_RS00905	COG3539	Fimbrial protein
Eco28_RS00910	COG2194	sulfuric ester hydrolase activity
Eco28_RS00925	COG0747	negative chemotaxis
Eco28_RS00935	COG0601	transmembrane transport
Eco28_RS00940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Eco28_RS00945	COG0444	Belongs to the ABC transporter superfamily
Eco28_RS00950	COG4608	Belongs to the ABC transporter superfamily
Eco28_RS00955	COG0814	amino acid
Eco28_RS00990	COG2194	sulfuric ester hydrolase activity
Eco28_RS01015	COG1215	transferase activity, transferring glycosyl groups
Eco28_RS01020	COG1215	transferase activity, transferring glycosyl groups
Eco28_RS01025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Eco28_RS01030	COG3118	belongs to the thioredoxin family
Eco28_RS01030	COG0457	Tetratricopeptide repeat
Eco28_RS01035	COG2199	diguanylate cyclase activity
Eco28_RS01035	COG2200	EAL domain
Eco28_RS01055	COG0612	Peptidase, M16
Eco28_RS01070	COG2200	EAL domain
Eco28_RS01075	COG2982	Protein involved in outer membrane biogenesis
Eco28_RS01080	COG0477	Major facilitator Superfamily
Eco28_RS01085	COG1295	ribonuclease BN
Eco28_RS01090	COG0583	DNA-binding transcription factor activity
Eco28_RS01095	COG2197	response regulator
Eco28_RS01105	COG1858	cytochrome C peroxidase
Eco28_RS01110	COG0076	glutamate decarboxylase activity
Eco28_RS01120	COG2207	Transcriptional regulator
Eco28_RS01130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Eco28_RS01135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS01145	COG2771	luxR family
Eco28_RS01150	COG3247	response to pH
Eco28_RS01165	COG1285	pathogenesis
Eco28_RS01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Eco28_RS01190	COG4558	Periplasmic binding protein
Eco28_RS01200	COG4771	TonB-dependent receptor
Eco28_RS01205	COG3720	iron ion transport
Eco28_RS01210	COG2197	response regulator
Eco28_RS01220	COG3065	identical protein binding
Eco28_RS01235	COG1393	Belongs to the ArsC family
Eco28_RS01250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Eco28_RS01255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Eco28_RS01260	COG0339	signal peptide processing
Eco28_RS01270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Eco28_RS01275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Eco28_RS01280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Eco28_RS01285	COG0371	Dehydrogenase
Eco28_RS01290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS01290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS01295	COG0246	Mannitol dehydrogenase
Eco28_RS01300	COG1349	DNA-binding transcription factor activity
Eco28_RS01310	COG2213	PTS system mannitol-specific
Eco28_RS01310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS01320	COG3104	oligopeptide transport
Eco28_RS01330	COG0589	response to stress
Eco28_RS01340	COG0306	phosphate transporter
Eco28_RS01345	COG2081	HI0933 family
Eco28_RS01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS01395	COG1129	ABC transporter
Eco28_RS01395	COG0842	Transport permease protein
Eco28_RS01400	COG0842	Transport permease protein
Eco28_RS01430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Eco28_RS01435	COG0601	transmembrane transport
Eco28_RS01440	COG0747	negative chemotaxis
Eco28_RS01445	COG2091	lysine biosynthetic process via aminoadipic acid
Eco28_RS01450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Eco28_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS01465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Eco28_RS01490	COG1216	Glycosyl transferase, family 2
Eco28_RS01510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Eco28_RS01520	COG0204	Acyl-transferase
Eco28_RS01540	COG0628	permease
Eco28_RS01555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Eco28_RS01575	COG3714	YhhN family
Eco28_RS01585	COG3776	membrane
Eco28_RS01590	COG0742	ribosomal rna small subunit methyltransferase
Eco28_RS01595	COG0552	protein localization to endoplasmic reticulum
Eco28_RS01600	COG2884	Cell division ATP-binding protein ftsE
Eco28_RS01605	COG2177	Part of the ABC transporter FtsEX involved in
Eco28_RS01610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Eco28_RS01615	COG0683	leucine binding
Eco28_RS01630	COG0456	acetyltransferase
Eco28_RS01640	COG0683	leucine binding
Eco28_RS01645	COG0559	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS01650	COG4177	L-phenylalanine transmembrane transporter activity
Eco28_RS01655	COG0411	ABC transporter
Eco28_RS01660	COG0410	ABC transporter
Eco28_RS01670	COG1653	transport
Eco28_RS01675	COG1175	transmembrane transport
Eco28_RS01685	COG3842	ATPase activity
Eco28_RS01690	COG0584	glycerophosphoryl diester phosphodiesterase
Eco28_RS01700	COG0405	Gamma-glutamyltransferase
Eco28_RS01715	COG1247	-acetyltransferase
Eco28_RS01725	COG0673	inositol 2-dehydrogenase activity
Eco28_RS01730	COG1741	Belongs to the pirin family
Eco28_RS01735	COG1609	Transcriptional regulator
Eco28_RS01740	COG3265	gluconokinase activity
Eco28_RS01745	COG2610	gluconate transmembrane transporter activity
Eco28_RS01750	COG0514	ATP-dependent DNA helicase (RecQ)
Eco28_RS01760	COG2095	MarC family integral membrane protein
Eco28_RS01765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Eco28_RS01770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Eco28_RS01790	COG0058	SHG alpha-glucan phosphorylase activity
Eco28_RS01795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Eco28_RS01825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Eco28_RS01840	COG1349	DNA-binding transcription factor activity
Eco28_RS01845	COG4650	regulator
Eco28_RS01855	COG4650	regulator
Eco28_RS01860	COG1690	Belongs to the RtcB family
Eco28_RS01875	COG0058	SHG alpha-glucan phosphorylase activity
Eco28_RS01880	COG1640	4-alpha-glucanotransferase
Eco28_RS01885	COG2610	gluconate transmembrane transporter activity
Eco28_RS01895	COG1040	competence protein
Eco28_RS01905	COG5464	transposase or invertase
Eco28_RS01920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Eco28_RS01925	COG1918	ferrous iron import across plasma membrane
Eco28_RS01935	COG2183	response to ionizing radiation
Eco28_RS01940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Eco28_RS01970	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Eco28_RS01980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Eco28_RS01985	COG1011	Hydrolase
Eco28_RS01995	COG0494	nUDIX hydrolase
Eco28_RS02000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Eco28_RS02005	COG4972	Pilus assembly protein
Eco28_RS02010	COG3166	PFAM Fimbrial assembly family protein
Eco28_RS02025	COG4796	Type ii and iii secretion system protein
Eco28_RS02040	COG3266	domain, Protein
Eco28_RS02045	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Eco28_RS02050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Eco28_RS02060	COG0180	Tryptophanyl-tRNA synthetase
Eco28_RS02065	COG2188	Transcriptional regulator
Eco28_RS02075	COG1082	Xylose isomerase domain protein TIM barrel
Eco28_RS02085	COG2222	sugar isomerase
Eco28_RS02090	COG0531	amino acid
Eco28_RS02105	COG2116	formate transmembrane transporter activity
Eco28_RS02110	COG2146	nitrite reductase [NAD(P)H] activity
Eco28_RS02115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Eco28_RS02125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Eco28_RS02135	COG2184	nucleotidyltransferase activity
Eco28_RS02140	COG0512	Glutamine amidotransferase of anthranilate synthase
Eco28_RS02145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Eco28_RS02150	COG1289	transmembrane transporter activity
Eco28_RS02155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Eco28_RS02165	COG1765	OsmC-like protein
Eco28_RS02170	COG3954	Phosphoribulokinase
Eco28_RS02180	COG0429	hydrolase of the alpha beta-hydrolase fold
Eco28_RS02185	COG0488	(ABC) transporter
Eco28_RS02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
Eco28_RS02210	COG1047	Peptidyl-prolyl cis-trans
Eco28_RS02220	COG0545	Peptidyl-prolyl cis-trans isomerase
Eco28_RS02225	COG2964	Protein conserved in bacteria
Eco28_RS02305	COG0089	rRNA binding
Eco28_RS02395	COG0201	protein transport
Eco28_RS02435	COG0789	Transcriptional regulator
Eco28_RS02440	COG3036	rescue of stalled ribosome
Eco28_RS02450	COG0569	domain protein
Eco28_RS02470	COG0758	DNA mediated transformation
Eco28_RS02480	COG0551	DNA topoisomerase type I activity
Eco28_RS02500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Eco28_RS02540	COG1126	abc transporter atp-binding protein
Eco28_RS02545	COG0765	amino acid transport
Eco28_RS02550	COG4597	amino acid ABC transporter
Eco28_RS02555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS02570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Eco28_RS02575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS02585	COG1309	transcriptional regulator
Eco28_RS02595	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Eco28_RS02605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Eco28_RS02615	COG4145	pantothenate transmembrane transporter activity
Eco28_RS02620	COG3924	membrane
Eco28_RS02625	COG0439	Biotin carboxylase
Eco28_RS02630	COG0511	ligase activity, forming carbon-carbon bonds
Eco28_RS02640	COG0604	alcohol dehydrogenase
Eco28_RS02645	COG2200	EAL domain
Eco28_RS02645	COG2199	diguanylate cyclase activity
Eco28_RS02660	COG1077	Cell shape determining protein MreB Mrl
Eco28_RS02665	COG1792	Involved in formation and maintenance of cell shape
Eco28_RS02670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Eco28_RS02675	COG0424	maF-like protein
Eco28_RS02680	COG1530	ribonuclease E activity
Eco28_RS02685	COG3164	Protein of unknown function
Eco28_RS02690	COG0312	modulator of DNA gyrase
Eco28_RS02695	COG0583	DNA-binding transcription factor activity
Eco28_RS02715	COG2732	(Barnase) inhibitor
Eco28_RS02735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Eco28_RS02740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Eco28_RS02745	COG3105	Protein conserved in bacteria
Eco28_RS02750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Eco28_RS02775	COG0625	glutathione transferase activity
Eco28_RS02780	COG2969	positive regulation of protein catabolic process
Eco28_RS02785	COG3069	C4-dicarboxylate transmembrane transporter activity
Eco28_RS02820	COG2731	YhcH YjgK YiaL family protein
Eco28_RS02825	COG4804	nuclease activity
Eco28_RS02830	COG0493	'glutamate synthase
Eco28_RS02835	COG0070	glutamate synthase
Eco28_RS02835	COG0069	glutamate synthase activity
Eco28_RS02835	COG0067	glutamate synthase
Eco28_RS02850	COG1242	4 iron, 4 sulfur cluster binding
Eco28_RS02855	COG0784	Response regulator, receiver
Eco28_RS02855	COG2198	Histidine kinase
Eco28_RS02855	COG5002	protein histidine kinase activity
Eco28_RS02860	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Eco28_RS02870	COG0515	serine threonine protein kinase
Eco28_RS02875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS02890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Eco28_RS02895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Eco28_RS02900	COG1137	ATPase activity
Eco28_RS02905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Eco28_RS02910	COG3117	lipopolysaccharide transmembrane transporter activity
Eco28_RS02915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Eco28_RS02920	COG0517	IMP dehydrogenase activity
Eco28_RS02920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Eco28_RS02925	COG0530	calcium, potassium:sodium antiporter activity
Eco28_RS02930	COG1127	ABC transporter
Eco28_RS02935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Eco28_RS02940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Eco28_RS02945	COG2854	intermembrane phospholipid transfer
Eco28_RS02950	COG3113	response to antibiotic
Eco28_RS02955	COG5007	Belongs to the BolA IbaG family
Eco28_RS02965	COG3423	Transcriptional regulator
Eco28_RS02970	COG0142	geranyltranstransferase activity
Eco28_RS02985	COG0697	spore germination
Eco28_RS02995	COG2027	D-alanyl-D-alanine carboxypeptidase
Eco28_RS03000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Eco28_RS03005	COG1534	Rna-binding protein
Eco28_RS03015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Eco28_RS03020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Eco28_RS03030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Eco28_RS03045	COG2194	sulfuric ester hydrolase activity
Eco28_RS03065	COG0195	Participates in both transcription termination and antitermination
Eco28_RS03105	COG0513	Belongs to the DEAD box helicase family
Eco28_RS03110	COG0814	amino acid
Eco28_RS03115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Eco28_RS03120	COG0826	peptidase U32
Eco28_RS03125	COG0826	peptidase U32
Eco28_RS03130	COG3154	lipid carrier protein
Eco28_RS03135	COG3153	acetyltransferase
Eco28_RS03150	COG0693	protein deglycase activity
Eco28_RS03155	COG0702	epimerase
Eco28_RS03160	COG0701	Predicted permease
Eco28_RS03165	COG2823	Periplasmic or secreted lipoprotein
Eco28_RS03185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Eco28_RS03190	COG3539	Fimbrial protein
Eco28_RS03195	COG3188	usher protein
Eco28_RS03200	COG3121	Chaperone
Eco28_RS03205	COG3539	Fimbrial protein
Eco28_RS03210	COG0363	glucosamine-6-phosphate deaminase activity
Eco28_RS03215	COG3716	PTS system mannose fructose sorbose family IID component
Eco28_RS03220	COG3715	PTS system
Eco28_RS03225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS03235	COG2222	sugar isomerase
Eco28_RS03240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Eco28_RS03245	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS03250	COG3716	PTS system mannose fructose sorbose family IID component
Eco28_RS03260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS03275	COG1349	DNA-binding transcription factor activity
Eco28_RS03285	COG2002	toxin-antitoxin pair type II binding
Eco28_RS03290	COG2721	sulfolactate sulfo-lyase activity
Eco28_RS03295	COG2271	Major facilitator Superfamily
Eco28_RS03305	COG2084	Dehydrogenase
Eco28_RS03310	COG1929	Belongs to the glycerate kinase type-1 family
Eco28_RS03335	COG0583	DNA-binding transcription factor activity
Eco28_RS03340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Eco28_RS03350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Eco28_RS03355	COG1882	Formate acetyltransferase
Eco28_RS03360	COG0251	oxidation-reduction process
Eco28_RS03365	COG1760	l-serine dehydratase
Eco28_RS03370	COG0814	amino acid
Eco28_RS03385	COG1741	Belongs to the pirin family
Eco28_RS03390	COG0583	DNA-binding transcription factor activity
Eco28_RS03400	COG3152	Membrane
Eco28_RS03405	COG3152	Membrane
Eco28_RS03410	COG0435	Glutathione S-transferase
Eco28_RS03415	COG2259	Doxx family
Eco28_RS03425	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
Eco28_RS03430	COG4575	ribosome binding
Eco28_RS03435	COG1422	Protein of unknown function (DUF1090)
Eco28_RS03445	COG0586	Pfam SNARE associated Golgi protein
Eco28_RS03450	COG2186	Transcriptional regulator
Eco28_RS03455	COG2271	Major facilitator Superfamily
Eco28_RS03465	COG2721	sulfolactate sulfo-lyase activity
Eco28_RS03475	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Eco28_RS03485	COG0861	Integral membrane protein TerC family
Eco28_RS03490	COG0673	inositol 2-dehydrogenase activity
Eco28_RS03495	COG2949	membrane
Eco28_RS03500	COG1451	nucleotide metabolic process
Eco28_RS03515	COG5499	transcription regulator containing HTH domain
Eco28_RS03520	COG1902	pentaerythritol trinitrate reductase activity
Eco28_RS03520	COG0446	pyridine nucleotide-disulphide oxidoreductase
Eco28_RS03530	COG3408	Glycogen debranching enzyme
Eco28_RS03530	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Eco28_RS03540	COG0531	amino acid
Eco28_RS03545	COG2731	YhcH YjgK YiaL family protein
Eco28_RS03550	COG3250	beta-galactosidase activity
Eco28_RS03555	COG1609	Transcriptional regulator
Eco28_RS03565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Eco28_RS03580	COG0840	transmembrane signaling receptor activity
Eco28_RS03585	COG1695	Transcriptional regulator
Eco28_RS03595	COG2375	cellular response to nickel ion
Eco28_RS03610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Eco28_RS03620	COG0358	DNA primase activity
Eco28_RS03625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Eco28_RS03640	COG0471	metal ion transport
Eco28_RS03645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS03650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS03670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Eco28_RS03685	COG4991	sh3 domain protein
Eco28_RS03695	COG3025	triphosphatase activity
Eco28_RS03715	COG2268	Band 7 protein
Eco28_RS03720	COG1585	Membrane protein implicated in regulation of membrane protease activity
Eco28_RS03750	COG3384	dioxygenase
Eco28_RS03755	COG0754	glutathionylspermidine amidase activity
Eco28_RS03770	COG1538	Outer membrane efflux protein
Eco28_RS03775	COG0494	nUDIX hydrolase
Eco28_RS03780	COG3151	Protein conserved in bacteria
Eco28_RS03785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Eco28_RS03790	COG3150	esterase
Eco28_RS03795	COG0187	DNA topoisomerase II activity
Eco28_RS03800	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Eco28_RS03805	COG2249	NAD(P)H dehydrogenase (quinone) activity
Eco28_RS03810	COG0642	Histidine kinase
Eco28_RS03815	COG0745	RESPONSE REGULATOR receiver
Eco28_RS03820	COG3111	PFAM Bacterial OB fold (BOF) protein
Eco28_RS03825	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Eco28_RS03835	COG2944	sequence-specific DNA binding
Eco28_RS03840	COG4166	transmembrane transport
Eco28_RS03845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Eco28_RS03850	COG0204	Acyl-transferase
Eco28_RS03855	COG2132	Multicopper oxidase
Eco28_RS03860	COG1032	radical SAM domain protein
Eco28_RS03865	COG4238	major outer membrane lipoprotein
Eco28_RS03875	COG0656	L-ascorbic acid biosynthetic process
Eco28_RS03880	COG1979	alcohol dehydrogenase
Eco28_RS03885	COG2207	Transcriptional regulator
Eco28_RS03890	COG0586	Pfam SNARE associated Golgi protein
Eco28_RS03895	COG0626	cystathionine gamma-synthase activity
Eco28_RS03905	COG0811	peptide transport
Eco28_RS03910	COG0848	biopolymer transport protein
Eco28_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS03925	COG0667	Aldo Keto reductase
Eco28_RS03945	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Eco28_RS03950	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS03955	COG5557	Pfam Polysulphide reductase, NrfD
Eco28_RS03960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Eco28_RS03970	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Eco28_RS03975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Eco28_RS03980	COG1773	rubredoxin
Eco28_RS03990	COG0298	carbon dioxide binding
Eco28_RS03995	COG0625	glutathione transferase activity
Eco28_RS04000	COG0754	glutathionylspermidine amidase activity
Eco28_RS04010	COG0306	phosphate transporter
Eco28_RS04015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Eco28_RS04020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Eco28_RS04025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Eco28_RS04030	COG2244	polysaccharide biosynthetic process
Eco28_RS04040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Eco28_RS04045	COG0795	lipopolysaccharide-transporting ATPase activity
Eco28_RS04055	COG0156	8-amino-7-oxononanoate synthase activity
Eco28_RS04060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Eco28_RS04070	COG0318	PFAM AMP-dependent synthetase and ligase
Eco28_RS04075	COG0456	acetyltransferase
Eco28_RS04080	COG2186	Transcriptional regulator
Eco28_RS04085	COG0277	FAD linked oxidase domain protein
Eco28_RS04090	COG0277	FAD linked oxidase domain protein
Eco28_RS04095	COG0247	lactate metabolic process
Eco28_RS04100	COG3193	protein, possibly involved in utilization of glycolate and propanediol
Eco28_RS04105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Eco28_RS04110	COG1620	l-lactate permease
Eco28_RS04150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Eco28_RS04155	COG1459	type II secretion system
Eco28_RS04160	COG2165	general secretion pathway protein
Eco28_RS04190	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Eco28_RS04275	COG2003	Belongs to the UPF0758 family
Eco28_RS04300	COG2378	regulation of single-species biofilm formation
Eco28_RS04305	COG3596	GTP binding
Eco28_RS04335	COG2916	Histone family protein nucleoid-structuring protein H-NS
Eco28_RS04400	COG3344	reverse transcriptase
Eco28_RS04415	COG2801	Transposase and inactivated derivatives
Eco28_RS04435	COG3039	Transposase
Eco28_RS04470	COG3069	C4-dicarboxylate transmembrane transporter activity
Eco28_RS04475	COG1737	Transcriptional regulator
Eco28_RS04480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Eco28_RS04520	COG1653	transport
Eco28_RS04540	COG0582	viral genome integration into host DNA
Eco28_RS04550	COG1811	Na channel or pump
Eco28_RS04560	COG1982	Orn Lys Arg decarboxylase major
Eco28_RS04565	COG2211	Major facilitator Superfamily
Eco28_RS04580	COG1194	a g-specific adenine glycosylase
Eco28_RS04595	COG3171	Protein conserved in bacteria
Eco28_RS04605	COG0252	asparaginase activity
Eco28_RS04615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Eco28_RS04630	COG0762	integral membrane protein
Eco28_RS04635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Eco28_RS04640	COG2805	Type II/IV secretion system protein
Eco28_RS04655	COG0189	ligase activity
Eco28_RS04660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Eco28_RS04665	COG2356	endonuclease I
Eco28_RS04675	COG2814	Major facilitator Superfamily
Eco28_RS04700	COG1166	arginine decarboxylase activity
Eco28_RS04715	COG0501	Belongs to the peptidase M48B family
Eco28_RS04720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Eco28_RS04725	COG0330	HflC and HflK could
Eco28_RS04735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS04740	COG2213	PTS system mannitol-specific
Eco28_RS04745	COG1063	alcohol dehydrogenase
Eco28_RS04750	COG1494	fructose-1,6-bisphosphatase
Eco28_RS04760	COG1072	(Pantothenic acid kinase))
Eco28_RS04765	COG1122	ATPase activity
Eco28_RS04770	COG1122	ATPase activity
Eco28_RS04805	COG0191	fructose-bisphosphate aldolase activity
Eco28_RS04810	COG0668	transmembrane transport
Eco28_RS04815	COG1279	arginine transmembrane transporter activity
Eco28_RS04820	COG2968	Membrane
Eco28_RS04825	COG0583	DNA-binding transcription factor activity
Eco28_RS04830	COG0427	acetyl-CoA hydrolase
Eco28_RS04835	COG1024	Enoyl-CoA hydratase
Eco28_RS04840	COG1703	isobutyryl-CoA mutase activity
Eco28_RS04845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Eco28_RS04845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Eco28_RS04870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Eco28_RS04890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Eco28_RS04915	COG0006	proline dipeptidase activity
Eco28_RS04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Eco28_RS04925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Eco28_RS04945	COG2723	6-phospho-beta-galactosidase activity
Eco28_RS04955	COG1272	protein, Hemolysin III
Eco28_RS04970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Eco28_RS04980	COG0716	FMN binding
Eco28_RS04985	COG4974	Belongs to the 'phage' integrase family
Eco28_RS04990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Eco28_RS04995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Eco28_RS05005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Eco28_RS05020	COG2233	PERMEase
Eco28_RS05030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS05030	COG0493	'glutamate synthase
Eco28_RS05035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS05040	COG2252	PERMEase
Eco28_RS05045	COG0402	S-adenosylhomocysteine deaminase activity
Eco28_RS05050	COG2233	PERMEase
Eco28_RS05055	COG2080	2 iron, 2 sulfur cluster binding
Eco28_RS05055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Eco28_RS05060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Eco28_RS05065	COG0402	S-adenosylhomocysteine deaminase activity
Eco28_RS05070	COG0493	'glutamate synthase
Eco28_RS05070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS05075	COG2068	MobA-Related Protein
Eco28_RS05080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Eco28_RS05085	COG3608	succinylglutamate desuccinylase aspartoacylase
Eco28_RS05085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Eco28_RS05090	COG0549	Belongs to the carbamate kinase family
Eco28_RS05100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Eco28_RS05105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Eco28_RS05110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Eco28_RS05115	COG3829	transcription factor binding
Eco28_RS05120	COG2080	2 iron, 2 sulfur cluster binding
Eco28_RS05125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Eco28_RS05130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Eco28_RS05140	COG4942	peptidase
Eco28_RS05150	COG3387	PFAM Glycoside hydrolase 15-related
Eco28_RS05160	COG2207	Transcriptional regulator
Eco28_RS05260	COG2197	response regulator
Eco28_RS05265	COG0741	lytic transglycosylase activity
Eco28_RS05275	COG0457	Tetratricopeptide repeat
Eco28_RS05275	COG3710	Transcriptional regulator
Eco28_RS05280	COG0457	Tetratricopeptide repeat
Eco28_RS05315	COG3710	Transcriptional regulator
Eco28_RS05320	COG2771	luxR family
Eco28_RS05325	COG0814	amino acid
Eco28_RS05335	COG0814	amino acid
Eco28_RS05340	COG0183	Belongs to the thiolase family
Eco28_RS05350	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS05355	COG2814	Major facilitator Superfamily
Eco28_RS05360	COG1794	racemase activity, acting on amino acids and derivatives
Eco28_RS05365	COG0583	DNA-binding transcription factor activity
Eco28_RS05375	COG1609	Transcriptional regulator
Eco28_RS05390	COG0667	Aldo Keto reductase
Eco28_RS05400	COG0861	Integral membrane protein TerC family
Eco28_RS05415	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
Eco28_RS05430	COG2165	general secretion pathway protein
Eco28_RS05435	COG4795	General secretion pathway protein
Eco28_RS05445	COG4967	type IV pilus modification protein PilV
Eco28_RS05450	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Eco28_RS05455	COG1025	Belongs to the peptidase M16 family
Eco28_RS05460	COG1074	ATP-dependent DNA helicase activity
Eco28_RS05465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Eco28_RS05470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Eco28_RS05470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Eco28_RS05475	COG0860	N-Acetylmuramoyl-L-alanine amidase
Eco28_RS05500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Eco28_RS05505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Eco28_RS05510	COG2166	iron-sulfur cluster assembly
Eco28_RS05515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Eco28_RS05525	COG0583	DNA-binding transcription factor activity
Eco28_RS05530	COG2363	Small membrane protein
Eco28_RS05540	COG1349	DNA-binding transcription factor activity
Eco28_RS05550	COG1070	Carbohydrate kinase
Eco28_RS05560	COG0738	Major facilitator superfamily
Eco28_RS05565	COG0235	Class ii aldolase
Eco28_RS05570	COG1454	alcohol dehydrogenase
Eco28_RS05580	COG1760	l-serine dehydratase
Eco28_RS05585	COG0814	amino acid
Eco28_RS05590	COG1611	Belongs to the LOG family
Eco28_RS05605	COG3098	single-species biofilm formation
Eco28_RS05610	COG0564	pseudouridine synthase activity
Eco28_RS05615	COG0716	FMN binding
Eco28_RS05620	COG2271	Major facilitator Superfamily
Eco28_RS05625	COG4948	Mandelate Racemase Muconate Lactonizing
Eco28_RS05630	COG4948	Mandelate Racemase Muconate Lactonizing
Eco28_RS05635	COG2205	protein histidine kinase activity
Eco28_RS05635	COG4999	Histidine kinase
Eco28_RS05635	COG3850	Histidine kinase
Eco28_RS05635	COG3437	response regulator, receiver
Eco28_RS05645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Eco28_RS05650	COG2336	PFAM SpoVT AbrB
Eco28_RS05655	COG2337	Toxic component of a toxin-antitoxin (TA) module
Eco28_RS05660	COG3956	TIGRFAM MazG family protein
Eco28_RS05675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Eco28_RS05685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Eco28_RS05695	COG0602	queuosine metabolic process
Eco28_RS05700	COG1070	Carbohydrate kinase
Eco28_RS05705	COG2223	nitrite transmembrane transporter activity
Eco28_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS05715	COG0277	FAD linked oxidase domain protein
Eco28_RS05720	COG0477	Major facilitator Superfamily
Eco28_RS05725	COG2086	electron transfer activity
Eco28_RS05730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Eco28_RS05735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Eco28_RS05740	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Eco28_RS05745	COG0644	oxidoreductase
Eco28_RS05750	COG0720	synthase
Eco28_RS05780	COG1203	CRISPR-associated helicase, Cas3
Eco28_RS05800	COG1857	crispr-associated protein
Eco28_RS05815	COG1518	maintenance of DNA repeat elements
Eco28_RS05820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Eco28_RS05825	COG2234	aminopeptidase activity
Eco28_RS05880	COG1388	LysM domain
Eco28_RS05880	COG4942	peptidase
Eco28_RS05885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Eco28_RS05895	COG0163	prenyltransferase activity
Eco28_RS05900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Eco28_RS05910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Eco28_RS05930	COG3604	Transcriptional regulator
Eco28_RS05935	COG0309	Hydrogenase expression formation protein (HypE)
Eco28_RS05940	COG0409	Hydrogenase expression formation protein
Eco28_RS05945	COG0298	carbon dioxide binding
Eco28_RS05950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Eco28_RS05955	COG0375	protein maturation
Eco28_RS05970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS05975	COG0651	ATP synthesis coupled electron transport
Eco28_RS05980	COG0650	Formate hydrogenlyase subunit 4
Eco28_RS05985	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Eco28_RS05985	COG3261	NADH dehydrogenase
Eco28_RS05990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Eco28_RS05995	COG3260	NADH ubiquinone oxidoreductase 20
Eco28_RS06005	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Eco28_RS06010	COG5499	transcription regulator containing HTH domain
Eco28_RS06015	COG2723	6-phospho-beta-galactosidase activity
Eco28_RS06020	COG1263	PTS System
Eco28_RS06020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS06025	COG1609	Transcriptional regulator
Eco28_RS06030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS06035	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Eco28_RS06060	COG1349	DNA-binding transcription factor activity
Eco28_RS06065	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS06080	COG3732	PTS system glucitol sorbitol-specific
Eco28_RS06085	COG3730	PTS system glucitol sorbitol-specific
Eco28_RS06090	COG2951	lytic endotransglycosylase activity
Eco28_RS06095	COG1546	Belongs to the CinA family
Eco28_RS06115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Eco28_RS06140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Eco28_RS06145	COG1238	metal cluster binding
Eco28_RS06160	COG2814	Major facilitator Superfamily
Eco28_RS06165	COG1566	PFAM secretion protein HlyD family protein
Eco28_RS06170	COG1846	Transcriptional regulator
Eco28_RS06180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Eco28_RS06185	COG2814	Major facilitator Superfamily
Eco28_RS06190	COG2113	Glycine betaine
Eco28_RS06195	COG4176	ABC-type proline glycine betaine transport system permease component
Eco28_RS06200	COG4175	Glycine betaine
Eco28_RS06210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Eco28_RS06215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Eco28_RS06225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Eco28_RS06235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Eco28_RS06245	COG4575	ribosome binding
Eco28_RS06260	COG2916	Histone family protein nucleoid-structuring protein H-NS
Eco28_RS06265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Eco28_RS06270	COG0640	Transcriptional regulator
Eco28_RS06275	COG0401	homolog of Blt101
Eco28_RS06280	COG1652	LysM domain
Eco28_RS06285	COG1802	Transcriptional regulator
Eco28_RS06290	COG1113	amino acid transport
Eco28_RS06295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Eco28_RS06300	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS06305	COG0579	oxidoreductase
Eco28_RS06350	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS06430	COG0582	viral genome integration into host DNA
Eco28_RS06445	COG2867	negative regulation of translational initiation
Eco28_RS06455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Eco28_RS06460	COG0497	DNA recombination
Eco28_RS06480	COG4536	flavin adenine dinucleotide binding
Eco28_RS06485	COG4137	Cytochrome C assembly protein
Eco28_RS06490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Eco28_RS06515	COG2885	chlorophyll binding
Eco28_RS06520	COG2199	diguanylate cyclase activity
Eco28_RS06535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Eco28_RS06540	COG1605	Chorismate mutase
Eco28_RS06540	COG0287	Prephenate dehydrogenase
Eco28_RS06545	COG0077	Prephenate dehydratase
Eco28_RS06545	COG1605	Chorismate mutase
Eco28_RS06550	COG4974	Belongs to the 'phage' integrase family
Eco28_RS06555	COG1396	sequence-specific DNA binding
Eco28_RS06635	COG4695	Portal protein
Eco28_RS06725	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS06740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS06795	COG2314	TM2 domain
Eco28_RS06810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Eco28_RS06820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Eco28_RS06825	COG0564	pseudouridine synthase activity
Eco28_RS06835	COG0542	response to heat
Eco28_RS06865	COG0477	Major facilitator Superfamily
Eco28_RS06870	COG5544	Lipoprotein
Eco28_RS06875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Eco28_RS06880	COG0045	succinate-CoA ligase (ADP-forming) activity
Eco28_RS06880	COG1042	CoA-binding domain protein
Eco28_RS06880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Eco28_RS06885	COG3148	PFAM DTW domain containing protein
Eco28_RS06890	COG3118	belongs to the thioredoxin family
Eco28_RS06900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Eco28_RS06915	COG1280	lysine exporter protein (LysE YggA)
Eco28_RS06920	COG0583	DNA-binding transcription factor activity
Eco28_RS06925	COG0513	Belongs to the DEAD box helicase family
Eco28_RS06935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Eco28_RS06940	COG1595	DNA-templated transcription, initiation
Eco28_RS06945	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
Eco28_RS06950	COG3026	antisigma factor binding
Eco28_RS06955	COG3086	response to oxidative stress
Eco28_RS06965	COG0681	Belongs to the peptidase S26 family
Eco28_RS06990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Eco28_RS07015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS07020	COG1737	Transcriptional regulator
Eco28_RS07025	COG0560	Phosphoserine phosphatase
Eco28_RS07030	COG0590	tRNA wobble adenosine to inosine editing
Eco28_RS07045	COG0047	phosphoribosylformylglycinamidine synthase activity
Eco28_RS07045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Eco28_RS07050	COG2205	protein histidine kinase activity
Eco28_RS07055	COG3170	Tfp pilus assembly protein FimV
Eco28_RS07060	COG2204	response regulator
Eco28_RS07065	COG0347	Belongs to the P(II) protein family
Eco28_RS07070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Eco28_RS07070	COG1017	nitric oxide dioxygenase activity
Eco28_RS07080	COG1940	carbohydrate kinase activity
Eco28_RS07085	COG0457	Tetratricopeptide repeat
Eco28_RS07090	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS07095	COG1129	ABC transporter
Eco28_RS07100	COG1172	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS07105	COG1063	alcohol dehydrogenase
Eco28_RS07110	COG2017	converts alpha-aldose to the beta-anomer
Eco28_RS07115	COG2259	Doxx family
Eco28_RS07140	COG4638	Rieske (2fe-2S)
Eco28_RS07145	COG0583	DNA-binding transcription factor activity
Eco28_RS07150	COG2814	Major facilitator Superfamily
Eco28_RS07155	COG3711	transcriptional antiterminator
Eco28_RS07160	COG1073	alpha beta
Eco28_RS07165	COG0483	inositol monophosphate 1-phosphatase activity
Eco28_RS07185	COG0822	iron-sulfur transferase activity
Eco28_RS07205	COG0633	Ferredoxin
Eco28_RS07210	COG2975	iron-sulfur cluster assembly
Eco28_RS07225	COG2897	thiosulfate sulfurtransferase activity
Eco28_RS07230	COG2373	Large extracellular alpha-helical protein
Eco28_RS07235	COG4953	penicillin-binding protein 1C
Eco28_RS07240	COG0243	molybdopterin cofactor binding
Eco28_RS07245	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS07250	COG3302	dmso reductase anchor subunit
Eco28_RS07285	COG2976	Protein conserved in bacteria
Eco28_RS07300	COG1645	bacterial-type flagellum-dependent swarming motility
Eco28_RS07310	COG0517	IMP dehydrogenase activity
Eco28_RS07310	COG0516	GMP reductase activity
Eco28_RS07350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Eco28_RS07430	COG5484	DNA packaging
Eco28_RS07430	COG3728	DNA packaging
Eco28_RS07555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Eco28_RS07570	COG3179	chitinase
Eco28_RS07585	COG3133	Outer membrane lipoprotein
Eco28_RS07605	COG2200	EAL domain
Eco28_RS07610	COG0248	Ppx GppA phosphatase
Eco28_RS07615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Eco28_RS07620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Eco28_RS07640	COG2233	PERMEase
Eco28_RS07650	COG1393	Belongs to the ArsC family
Eco28_RS07655	COG4783	chaperone-mediated protein folding
Eco28_RS07660	COG0628	permease
Eco28_RS07665	COG2116	formate transmembrane transporter activity
Eco28_RS07670	COG3604	Transcriptional regulator
Eco28_RS07680	COG3260	NADH ubiquinone oxidoreductase 20
Eco28_RS07685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Eco28_RS07690	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Eco28_RS07690	COG3261	NADH dehydrogenase
Eco28_RS07695	COG0651	ATP synthesis coupled electron transport
Eco28_RS07700	COG4237	Hydrogenase 4 membrane
Eco28_RS07705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Eco28_RS07710	COG0650	Formate hydrogenlyase subunit 4
Eco28_RS07715	COG0651	ATP synthesis coupled electron transport
Eco28_RS07720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS07725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Eco28_RS07730	COG2716	regulation of RNA biosynthetic process
Eco28_RS07740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Eco28_RS07760	COG2321	neutral zinc metallopeptidase
Eco28_RS07770	COG0400	carboxylic ester hydrolase activity
Eco28_RS07785	COG1393	Belongs to the ArsC family
Eco28_RS07800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Eco28_RS07805	COG3850	Histidine kinase
Eco28_RS07810	COG0493	'glutamate synthase
Eco28_RS07810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS07820	COG5342	invasion associated locus B
Eco28_RS07825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Eco28_RS07830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Eco28_RS07840	COG0280	phosphate acetyltransferase
Eco28_RS07840	COG0281	malic enzyme
Eco28_RS07845	COG4810	utilization protein
Eco28_RS07850	COG4917	ethanolamine utilization protein
Eco28_RS07855	COG4766	ethanolamine catabolic process
Eco28_RS07860	COG4812	Cobalamin adenosyltransferase
Eco28_RS07865	COG0280	phosphate acetyltransferase
Eco28_RS07870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Eco28_RS07875	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Eco28_RS07880	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS07885	COG4820	ethanolamine utilization protein (EutJ)
Eco28_RS07890	COG1454	alcohol dehydrogenase
Eco28_RS07895	COG3192	ethanolamine utilization protein
Eco28_RS07900	COG4819	ethanolamine utilization protein
Eco28_RS07905	COG4303	Ethanolamine ammonia lyase large subunit
Eco28_RS07915	COG4816	utilization protein
Eco28_RS07920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Eco28_RS07925	COG2207	Transcriptional regulator
Eco28_RS07935	COG0860	N-Acetylmuramoyl-L-alanine amidase
Eco28_RS07955	COG2837	iron assimilation
Eco28_RS07960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Eco28_RS07965	COG1263	PTS System
Eco28_RS07965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS07985	COG4150	thiosulfate binding
Eco28_RS07990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Eco28_RS07995	COG4208	sulfate ABC transporter
Eco28_RS08000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Eco28_RS08005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Eco28_RS08020	COG2190	(PTS) system
Eco28_RS08025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Eco28_RS08030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS08035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Eco28_RS08055	COG3530	Putative quorum-sensing-regulated virulence factor
Eco28_RS08060	COG0385	Bile acid
Eco28_RS08065	COG0583	DNA-binding transcription factor activity
Eco28_RS08115	COG3415	Transposase
Eco28_RS08120	COG3415	Transposase
Eco28_RS08135	COG2199	diguanylate cyclase activity
Eco28_RS08135	COG2200	EAL domain
Eco28_RS08140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Eco28_RS08165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS08170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS08175	COG0006	proline dipeptidase activity
Eco28_RS08180	COG1363	Peptidase, m42
Eco28_RS08190	COG2207	Transcriptional regulator
Eco28_RS08195	COG3279	Response regulator of the LytR AlgR family
Eco28_RS08200	COG3275	phosphorelay sensor kinase activity
Eco28_RS08205	COG0436	Aminotransferase
Eco28_RS08215	COG1560	Kdo2-lipid A biosynthetic process
Eco28_RS08240	COG0028	Belongs to the TPP enzyme family
Eco28_RS08245	COG0679	Auxin Efflux Carrier
Eco28_RS08250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Eco28_RS08255	COG2205	protein histidine kinase activity
Eco28_RS08255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS08255	COG2198	Histidine kinase
Eco28_RS08255	COG0784	Response regulator, receiver
Eco28_RS08260	COG2197	response regulator
Eco28_RS08265	COG1566	PFAM secretion protein HlyD family protein
Eco28_RS08270	COG0477	Major facilitator Superfamily
Eco28_RS08280	COG2610	gluconate transmembrane transporter activity
Eco28_RS08315	COG2116	formate transmembrane transporter activity
Eco28_RS08325	COG2853	Lipoprotein
Eco28_RS08335	COG2067	long-chain fatty acid transport protein
Eco28_RS08345	COG3691	Protein conserved in bacteria
Eco28_RS08360	COG2062	phosphohistidine phosphatase, SixA
Eco28_RS08365	COG3539	Fimbrial protein
Eco28_RS08370	COG3188	usher protein
Eco28_RS08375	COG3121	Chaperone
Eco28_RS08380	COG3539	Fimbrial protein
Eco28_RS08385	COG3539	Fimbrial protein
Eco28_RS08390	COG3539	Fimbrial protein
Eco28_RS08405	COG2890	protein-(glutamine-N5) methyltransferase activity
Eco28_RS08420	COG0730	response to heat
Eco28_RS08425	COG3101	peptidyl-lysine hydroxylation
Eco28_RS08440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Eco28_RS08450	COG2814	Major facilitator Superfamily
Eco28_RS08465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Eco28_RS08475	COG0586	Pfam SNARE associated Golgi protein
Eco28_RS08485	COG0285	dihydrofolate synthase activity
Eco28_RS08490	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Eco28_RS08495	COG1286	toxin biosynthetic process
Eco28_RS08500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Eco28_RS08505	COG0163	prenyltransferase activity
Eco28_RS08510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS08515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS08520	COG4215	(ABC) transporter
Eco28_RS08525	COG4160	amino acid transport
Eco28_RS08530	COG4598	ABC transporter
Eco28_RS08535	COG5464	transposase or invertase
Eco28_RS08540	COG1090	epimerase
Eco28_RS08545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Eco28_RS08550	COG0625	glutathione transferase activity
Eco28_RS08555	COG0625	glutathione transferase activity
Eco28_RS08560	COG0622	Phosphoesterase
Eco28_RS08565	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Eco28_RS08570	COG1288	antiporter activity
Eco28_RS08575	COG0280	phosphate acetyltransferase
Eco28_RS08575	COG0857	belongs to the CobB CobQ family
Eco28_RS08580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Eco28_RS08595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Eco28_RS08600	COG0490	domain, Protein
Eco28_RS08600	COG0471	metal ion transport
Eco28_RS08610	COG0436	Aminotransferase
Eco28_RS08620	COG0583	DNA-binding transcription factor activity
Eco28_RS08640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Eco28_RS08645	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Eco28_RS08650	COG1034	ATP synthesis coupled electron transport
Eco28_RS08665	COG0839	Belongs to the complex I subunit 6 family
Eco28_RS08675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Eco28_RS08680	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Eco28_RS08720	COG2234	aminopeptidase activity
Eco28_RS08730	COG5160	protein modification by small protein removal
Eco28_RS08740	COG2153	protein acetylation
Eco28_RS08745	COG4575	ribosome binding
Eco28_RS08750	COG1169	isochorismate synthase
Eco28_RS08765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Eco28_RS08775	COG0318	PFAM AMP-dependent synthetase and ligase
Eco28_RS08840	COG1414	Transcriptional regulator
Eco28_RS08850	COG2271	Major facilitator Superfamily
Eco28_RS08865	COG5464	transposase or invertase
Eco28_RS08870	COG0247	lactate metabolic process
Eco28_RS08880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Eco28_RS08885	COG2271	Major facilitator Superfamily
Eco28_RS08890	COG0584	glycerophosphoryl diester phosphodiesterase
Eco28_RS08895	COG0583	DNA-binding transcription factor activity
Eco28_RS08905	COG2814	Major facilitator Superfamily
Eco28_RS08910	COG3642	lipopolysaccharide core region biosynthetic process
Eco28_RS08915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Eco28_RS08920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Eco28_RS08925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Eco28_RS08935	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS08945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Eco28_RS08950	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
Eco28_RS08955	COG3234	Protein of unknown function (DUF1175)
Eco28_RS08960	COG2373	Large extracellular alpha-helical protein
Eco28_RS08965	COG5445	Predicted secreted protein (DUF2300)
Eco28_RS08970	COG4676	Protein conserved in bacteria
Eco28_RS08980	COG2031	fatty acid transporter
Eco28_RS08985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Eco28_RS08990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Eco28_RS08995	COG2204	response regulator
Eco28_RS09000	COG3852	Histidine kinase
Eco28_RS09005	COG2205	protein histidine kinase activity
Eco28_RS09005	COG0784	Response regulator, receiver
Eco28_RS09010	COG2197	response regulator
Eco28_RS09015	COG0642	Histidine kinase
Eco28_RS09015	COG2198	Histidine kinase
Eco28_RS09030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Eco28_RS09035	COG1477	protein flavinylation
Eco28_RS09040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Eco28_RS09040	COG2169	Transcriptional regulator
Eco28_RS09045	COG3145	DNA-N1-methyladenine dioxygenase activity
Eco28_RS09050	COG4615	Cyclic peptide transporter
Eco28_RS09070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS09070	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
Eco28_RS09075	COG3062	negative regulation of establishment of protein localization
Eco28_RS09085	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS09090	COG0348	domain, Protein
Eco28_RS09095	COG3043	anaerobic respiration
Eco28_RS09100	COG3005	denitrification pathway
Eco28_RS09105	COG4133	protoheme IX ABC transporter activity
Eco28_RS09110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Eco28_RS09115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Eco28_RS09120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Eco28_RS09130	COG1138	Cytochrome C-type biogenesis protein
Eco28_RS09135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Eco28_RS09140	COG4235	cytochrome complex assembly
Eco28_RS09140	COG3088	subunit of a heme lyase
Eco28_RS09145	COG2197	response regulator
Eco28_RS09155	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS09165	COG3083	sulfuric ester hydrolase activity
Eco28_RS09185	COG1061	Type III restriction enzyme res subunit
Eco28_RS09195	COG1187	pseudouridine synthase activity
Eco28_RS09200	COG2814	Major facilitator Superfamily
Eco28_RS09215	COG4172	Belongs to the ABC transporter superfamily
Eco28_RS09220	COG4239	(ABC) transporter, permease
Eco28_RS09225	COG4174	ABC transporter (Permease)
Eco28_RS09230	COG4166	transmembrane transport
Eco28_RS09235	COG2200	EAL domain
Eco28_RS09240	COG0791	NLP P60 protein
Eco28_RS09245	COG0671	phosphoesterase, PA-phosphatase related
Eco28_RS09250	COG0523	cobalamin synthesis protein
Eco28_RS09255	COG0246	Mannitol dehydrogenase
Eco28_RS09270	COG2814	Major facilitator Superfamily
Eco28_RS09275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS09275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS09280	COG1105	Belongs to the carbohydrate kinase PfkB family
Eco28_RS09285	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Eco28_RS09285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS09285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS09290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS09295	COG2313	pseudouridylate synthase activity
Eco28_RS09300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Eco28_RS09305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Eco28_RS09315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Eco28_RS09320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS09320	COG1522	sequence-specific DNA binding
Eco28_RS09330	COG2855	membrane
Eco28_RS09335	COG0583	DNA-binding transcription factor activity
Eco28_RS09345	COG0833	amino acid
Eco28_RS09355	COG4771	TonB-dependent receptor
Eco28_RS09380	COG2311	Membrane
Eco28_RS09390	COG1609	Transcriptional regulator
Eco28_RS09395	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS09400	COG1129	ABC transporter
Eco28_RS09405	COG4211	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS09410	COG0167	dihydroorotate dehydrogenase activity
Eco28_RS09410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Eco28_RS09415	COG0493	'glutamate synthase
Eco28_RS09425	COG2949	membrane
Eco28_RS09435	COG1346	cytolysis
Eco28_RS09445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Eco28_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS09475	COG0586	Pfam SNARE associated Golgi protein
Eco28_RS09485	COG1686	Belongs to the peptidase S11 family
Eco28_RS09490	COG0277	FAD linked oxidase domain protein
Eco28_RS09495	COG1472	Belongs to the glycosyl hydrolase 3 family
Eco28_RS09500	COG1732	Glycine betaine
Eco28_RS09505	COG1174	glycine betaine transport
Eco28_RS09510	COG1125	glycine betaine transport
Eco28_RS09515	COG1174	glycine betaine transport
Eco28_RS09525	COG0789	Transcriptional regulator
Eco28_RS09530	COG3275	phosphorelay sensor kinase activity
Eco28_RS09535	COG3279	Response regulator of the LytR AlgR family
Eco28_RS09540	COG4807	Protein conserved in bacteria
Eco28_RS09545	COG4808	Protein conserved in bacteria
Eco28_RS09550	COG4715	Zinc finger, swim domain protein
Eco28_RS09555	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Eco28_RS09560	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Eco28_RS09565	COG0714	Associated with various cellular activities
Eco28_RS09585	COG3831	ATPase activity
Eco28_RS09605	COG0489	protein tyrosine kinase activity
Eco28_RS09620	COG3539	Fimbrial protein
Eco28_RS09625	COG3121	Chaperone
Eco28_RS09630	COG3188	usher protein
Eco28_RS09645	COG3188	usher protein
Eco28_RS09650	COG3539	Fimbrial protein
Eco28_RS09655	COG5455	response to cobalt ion
Eco28_RS09660	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Eco28_RS09675	COG0351	phosphomethylpyrimidine kinase
Eco28_RS09680	COG3757	hydrolase, family 25
Eco28_RS09685	COG2188	Transcriptional regulator
Eco28_RS09690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS09695	COG1397	ADP-ribosylglycohydrolase
Eco28_RS09700	COG2211	Major facilitator Superfamily
Eco28_RS09705	COG1830	Aldolase
Eco28_RS09730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS09735	COG3414	Phosphotransferase system galactitol-specific IIB component
Eco28_RS09740	COG3775	system Galactitol-specific IIC component
Eco28_RS09745	COG1063	alcohol dehydrogenase
Eco28_RS09790	COG0826	peptidase U32
Eco28_RS09800	COG0745	RESPONSE REGULATOR receiver
Eco28_RS09805	COG2205	protein histidine kinase activity
Eco28_RS09830	COG4245	von Willebrand factor, type A
Eco28_RS09835	COG0631	protein serine/threonine phosphatase activity
Eco28_RS09840	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
Eco28_RS09845	COG0443	Heat shock 70 kDa protein
Eco28_RS09855	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Eco28_RS09860	COG5002	protein histidine kinase activity
Eco28_RS09860	COG5001	Diguanylate cyclase
Eco28_RS09860	COG3447	MASE1 domain protein
Eco28_RS09865	COG0572	uridine kinase
Eco28_RS09875	COG2982	Protein involved in outer membrane biogenesis
Eco28_RS09880	COG1253	flavin adenine dinucleotide binding
Eco28_RS09885	COG1596	polysaccharide export
Eco28_RS09890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Eco28_RS09895	COG0489	protein tyrosine kinase activity
Eco28_RS09895	COG3206	protein involved in exopolysaccharide biosynthesis
Eco28_RS09900	COG0463	Glycosyl transferase, family 2
Eco28_RS09905	COG1045	serine acetyltransferase
Eco28_RS09910	COG0438	transferase activity, transferring glycosyl groups
Eco28_RS09920	COG1216	Glycosyl transferase, family 2
Eco28_RS09925	COG0110	maltose O-acetyltransferase activity
Eco28_RS09930	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Eco28_RS09935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Eco28_RS09940	COG1051	belongs to the nudix hydrolase family
Eco28_RS09945	COG0297	glycogen (starch) synthase activity
Eco28_RS09950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Eco28_RS09950	COG0662	Cupin 2, conserved barrel domain protein
Eco28_RS09955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Eco28_RS09960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Eco28_RS09965	COG2244	polysaccharide biosynthetic process
Eco28_RS09970	COG2327	Polysaccharide pyruvyl transferase
Eco28_RS09975	COG0438	transferase activity, transferring glycosyl groups
Eco28_RS09985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Eco28_RS09995	COG1088	dTDP-glucose 4,6-dehydratase activity
Eco28_RS10030	COG2030	dehydratase
Eco28_RS10050	COG1086	Polysaccharide biosynthesis protein
Eco28_RS10075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Eco28_RS10080	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Eco28_RS10085	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Eco28_RS10110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Eco28_RS10115	COG0131	Imidazoleglycerol-phosphate dehydratase
Eco28_RS10115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Eco28_RS10125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Eco28_RS10145	COG2161	toxin-antitoxin pair type II binding
Eco28_RS10150	COG4115	mRNA cleavage
Eco28_RS10155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Eco28_RS10160	COG0583	DNA-binding transcription factor activity
Eco28_RS10165	COG0531	amino acid
Eco28_RS10170	COG2391	methyltransferase activity
Eco28_RS10175	COG0425	Belongs to the sulfur carrier protein TusA family
Eco28_RS10180	COG2925	Exonuclease
Eco28_RS10185	COG1686	Belongs to the peptidase S11 family
Eco28_RS10195	COG1289	transmembrane transporter activity
Eco28_RS10205	COG4917	ethanolamine utilization protein
Eco28_RS10210	COG4372	Transposase
Eco28_RS10235	COG2003	Belongs to the UPF0758 family
Eco28_RS10285	COG4372	Transposase
Eco28_RS10290	COG3436	PFAM IS66 Orf2 family protein
Eco28_RS10325	COG2963	transposase activity
Eco28_RS10330	COG2826	transposase and inactivated derivatives, IS30 family
Eco28_RS10335	COG2963	transposase activity
Eco28_RS10420	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Eco28_RS10455	COG4771	TonB-dependent receptor
Eco28_RS10485	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Eco28_RS10500	COG1376	ErfK ybiS ycfS ynhG family protein
Eco28_RS10510	COG0583	DNA-binding transcription factor activity
Eco28_RS10515	COG0583	DNA-binding transcription factor activity
Eco28_RS10525	COG0534	Mate efflux family protein
Eco28_RS10540	COG0217	transcriptional regulatory protein
Eco28_RS10545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Eco28_RS10550	COG0477	Major facilitator Superfamily
Eco28_RS10590	COG3038	cytochrome b561
Eco28_RS10595	COG3443	Belongs to the bacterial solute-binding protein 9 family
Eco28_RS10610	COG3443	Belongs to the bacterial solute-binding protein 9 family
Eco28_RS10625	COG2351	hydroxyisourate hydrolase activity
Eco28_RS10630	COG0745	RESPONSE REGULATOR receiver
Eco28_RS10635	COG2205	protein histidine kinase activity
Eco28_RS10650	COG1418	mRNA catabolic process
Eco28_RS10655	COG0270	DNA (cytosine-5-)-methyltransferase activity
Eco28_RS10660	COG3727	T/G mismatch-specific endonuclease activity
Eco28_RS10665	COG0697	spore germination
Eco28_RS10670	COG2354	Protein conserved in bacteria
Eco28_RS10675	COG5475	Uncharacterized small protein (DUF2158)
Eco28_RS10710	COG2197	response regulator
Eco28_RS10715	COG1684	flagellar biosynthetic protein fliR
Eco28_RS10720	COG1987	bacterial-type flagellum assembly
Eco28_RS10725	COG1338	Plays a role in the flagellum-specific transport system
Eco28_RS10730	COG3190	flagellar
Eco28_RS10735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Eco28_RS10740	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Eco28_RS10745	COG1580	Controls the rotational direction of flagella during chemotaxis
Eco28_RS10750	COG3144	bacterial-type flagellum assembly
Eco28_RS10755	COG2882	bacterial-type flagellum organization
Eco28_RS10760	COG1157	protein secretion by the type III secretion system
Eco28_RS10765	COG1317	bacterial-type flagellum organization
Eco28_RS10770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Eco28_RS10775	COG1766	The M ring may be actively involved in energy transduction
Eco28_RS10800	COG0454	-acetyltransferase
Eco28_RS10805	COG2135	peptidase activity
Eco28_RS10810	COG0425	Belongs to the sulfur carrier protein TusA family
Eco28_RS10815	COG2391	methyltransferase activity
Eco28_RS10830	COG0366	Alpha amylase catalytic
Eco28_RS10840	COG1516	flagellar protein fliS
Eco28_RS10845	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Eco28_RS10860	COG1191	sigma factor activity
Eco28_RS10870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS10880	COG0765	amino acid transport
Eco28_RS10885	COG1126	abc transporter atp-binding protein
Eco28_RS10890	COG2197	response regulator
Eco28_RS10900	COG2197	response regulator
Eco28_RS10930	COG3012	SEC-C Motif Domain Protein
Eco28_RS10930	COG3318	Belongs to the UPF0149 family
Eco28_RS10935	COG0814	amino acid
Eco28_RS10945	COG1528	Iron-storage protein
Eco28_RS10965	COG1528	Iron-storage protein
Eco28_RS10975	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS10980	COG1129	ABC transporter
Eco28_RS10985	COG1172	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS10990	COG1877	trehalose-phosphatase activity
Eco28_RS11000	COG0589	response to stress
Eco28_RS11015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Eco28_RS11020	COG1360	Flagellar Motor Protein
Eco28_RS11025	COG0643	Histidine kinase
Eco28_RS11025	COG2198	Histidine kinase
Eco28_RS11030	COG0835	chemotaxis
Eco28_RS11035	COG0840	transmembrane signaling receptor activity
Eco28_RS11040	COG0840	transmembrane signaling receptor activity
Eco28_RS11045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Eco28_RS11050	COG2201	protein-glutamate methylesterase activity
Eco28_RS11055	COG0745	RESPONSE REGULATOR receiver
Eco28_RS11060	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Eco28_RS11065	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Eco28_RS11070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Eco28_RS11080	COG3755	Protein conserved in bacteria
Eco28_RS11095	COG3102	Protein conserved in bacteria
Eco28_RS11105	COG3005	denitrification pathway
Eco28_RS11110	COG0243	molybdopterin cofactor binding
Eco28_RS11125	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Eco28_RS11130	COG1801	Protein of unknown function DUF72
Eco28_RS11135	COG1335	isochorismatase
Eco28_RS11145	COG0494	nUDIX hydrolase
Eco28_RS11150	COG0217	transcriptional regulatory protein
Eco28_RS11180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Eco28_RS11190	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Eco28_RS11195	COG0739	heme binding
Eco28_RS11200	COG1560	Kdo2-lipid A biosynthetic process
Eco28_RS11205	COG0469	pyruvate kinase activity
Eco28_RS11210	COG1737	Transcriptional regulator
Eco28_RS11215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Eco28_RS11220	COG0129	dihydroxy-acid dehydratase activity
Eco28_RS11225	COG0800	Aldolase
Eco28_RS11235	COG3141	response to X-ray
Eco28_RS11245	COG2979	Protein of unknown function (DUF533)
Eco28_RS11260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Eco28_RS11265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Eco28_RS11275	COG2372	response to copper ion
Eco28_RS11280	COG1276	copper resistance
Eco28_RS11290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Eco28_RS11310	COG3008	intermembrane lipid transfer
Eco28_RS11315	COG2995	paraquat-inducible protein a
Eco28_RS11320	COG1956	GAF domain-containing protein
Eco28_RS11330	COG0793	Belongs to the peptidase S41A family
Eco28_RS11340	COG2814	Major facilitator Superfamily
Eco28_RS11345	COG2814	Major facilitator Superfamily
Eco28_RS11350	COG1414	Transcriptional regulator
Eco28_RS11385	COG2226	methyltransferase
Eco28_RS11405	COG3716	PTS system mannose fructose sorbose family IID component
Eco28_RS11410	COG3715	PTS system
Eco28_RS11415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS11415	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS11430	COG1253	flavin adenine dinucleotide binding
Eco28_RS11435	COG2200	EAL domain
Eco28_RS11440	COG1760	l-serine dehydratase
Eco28_RS11450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Eco28_RS11465	COG0251	oxidation-reduction process
Eco28_RS11470	COG1199	ATP-dependent helicase activity
Eco28_RS11475	COG1214	PFAM Peptidase M22, glycoprotease
Eco28_RS11480	COG3065	identical protein binding
Eco28_RS11485	COG0318	PFAM AMP-dependent synthetase and ligase
Eco28_RS11490	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Eco28_RS11495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Eco28_RS11500	COG4638	Rieske (2fe-2S)
Eco28_RS11505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Eco28_RS11510	COG0473	3-isopropylmalate dehydrogenase activity
Eco28_RS11515	COG0583	DNA-binding transcription factor activity
Eco28_RS11525	COG3615	Tellurite resistance protein tehB
Eco28_RS11535	COG2261	transglycosylase associated protein
Eco28_RS11550	COG2199	diguanylate cyclase activity
Eco28_RS11550	COG2203	Gaf domain
Eco28_RS11555	COG3042	response to heat
Eco28_RS11560	COG3189	MarR family transcriptional regulator
Eco28_RS11565	COG2807	transmembrane transport
Eco28_RS11570	COG2207	Transcriptional regulator
Eco28_RS11585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Eco28_RS11590	COG2199	diguanylate cyclase activity
Eco28_RS11595	COG2199	diguanylate cyclase activity
Eco28_RS11605	COG2766	serine protein kinase
Eco28_RS11610	COG3713	MltA-interacting MipA family protein
Eco28_RS11615	COG0656	L-ascorbic acid biosynthetic process
Eco28_RS11620	COG0676	glucose-6-phosphate 1-epimerase activity
Eco28_RS11625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Eco28_RS11635	COG3139	Protein of unknown function (DUF1315)
Eco28_RS11640	COG1063	alcohol dehydrogenase
Eco28_RS11645	COG2271	Major facilitator Superfamily
Eco28_RS11650	COG1063	alcohol dehydrogenase
Eco28_RS11655	COG0191	fructose-bisphosphate aldolase activity
Eco28_RS11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS11665	COG0667	Aldo Keto reductase
Eco28_RS11670	COG1349	DNA-binding transcription factor activity
Eco28_RS11680	COG2814	Major facilitator Superfamily
Eco28_RS11685	COG1335	isochorismatase
Eco28_RS11690	COG0252	asparaginase activity
Eco28_RS11695	COG0616	signal peptide processing
Eco28_RS11705	COG0778	Nitroreductase
Eco28_RS11715	COG0709	Synthesizes selenophosphate from selenide and ATP
Eco28_RS11720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Eco28_RS11730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Eco28_RS11740	COG0494	nUDIX hydrolase
Eco28_RS11745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Eco28_RS11750	COG2897	thiosulfate sulfurtransferase activity
Eco28_RS11755	COG4136	ATPase activity
Eco28_RS11760	COG4135	transport system, permease component
Eco28_RS11765	COG4134	Bacterial extracellular solute-binding protein
Eco28_RS11770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Eco28_RS11775	COG0398	Pfam SNARE associated Golgi protein
Eco28_RS11785	COG0398	Pfam SNARE associated Golgi protein
Eco28_RS11790	COG0708	Exodeoxyribonuclease III
Eco28_RS11820	COG3678	ATP-independent chaperone mediated protein folding
Eco28_RS11830	COG0322	excinuclease ABC activity
Eco28_RS11840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Eco28_RS11850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Eco28_RS11855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Eco28_RS11860	COG1447	Phosphotransferase system cellobiose-specific component IIA
Eco28_RS11865	COG1917	Cupin 2, conserved barrel domain protein
Eco28_RS11865	COG2169	Transcriptional regulator
Eco28_RS11870	COG1486	melibiose metabolic process
Eco28_RS11880	COG0753	catalase activity
Eco28_RS11895	COG1823	symporter activity
Eco28_RS11900	COG1988	membrane-bound metal-dependent
Eco28_RS11905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Eco28_RS11915	COG3001	Fructosamine kinase
Eco28_RS11925	COG1105	Belongs to the carbohydrate kinase PfkB family
Eco28_RS11930	COG3137	Salt-induced outer membrane protein
Eco28_RS11970	COG0072	phenylalanine-tRNA ligase activity
Eco28_RS11970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Eco28_RS11985	COG0386	Belongs to the glutathione peroxidase family
Eco28_RS11995	COG0791	NLP P60 protein
Eco28_RS12000	COG2200	EAL domain
Eco28_RS12010	COG4256	Hemin uptake protein
Eco28_RS12015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Eco28_RS12030	COG0574	Belongs to the PEP-utilizing enzyme family
Eco28_RS12030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Eco28_RS12035	COG0471	metal ion transport
Eco28_RS12040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Eco28_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS12060	COG0318	PFAM AMP-dependent synthetase and ligase
Eco28_RS12065	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Eco28_RS12070	COG0644	oxidoreductase
Eco28_RS12075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Eco28_RS12080	COG2086	electron transfer activity
Eco28_RS12090	COG2207	Transcriptional regulator
Eco28_RS12090	COG1917	Cupin 2, conserved barrel domain protein
Eco28_RS12095	COG1960	acyl-CoA dehydrogenase activity
Eco28_RS12100	COG4670	ketone body catabolic process
Eco28_RS12115	COG2271	Major facilitator Superfamily
Eco28_RS12125	COG2271	Major facilitator Superfamily
Eco28_RS12130	COG0738	Major facilitator superfamily
Eco28_RS12155	COG0628	permease
Eco28_RS12160	COG0247	lactate metabolic process
Eco28_RS12160	COG0277	FAD linked oxidase domain protein
Eco28_RS12165	COG2050	protein possibly involved in aromatic compounds catabolism
Eco28_RS12175	COG0316	Belongs to the HesB IscA family
Eco28_RS12180	COG0719	Fe-S assembly protein
Eco28_RS12185	COG0396	ATPase activity
Eco28_RS12190	COG0719	Fe-S assembly protein
Eco28_RS12205	COG1376	ErfK ybiS ycfS ynhG family protein
Eco28_RS12210	COG4238	major outer membrane lipoprotein
Eco28_RS12215	COG0469	pyruvate kinase activity
Eco28_RS12225	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS12230	COG2414	aldehyde ferredoxin oxidoreductase
Eco28_RS12240	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS12245	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Eco28_RS12255	COG4529	Protein conserved in bacteria
Eco28_RS12275	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS12285	COG0307	riboflavin synthase, alpha
Eco28_RS12290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Eco28_RS12295	COG2814	Major facilitator Superfamily
Eco28_RS12300	COG0583	DNA-binding transcription factor activity
Eco28_RS12320	COG2814	Major facilitator Superfamily
Eco28_RS12325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Eco28_RS12330	COG0791	NLP P60 protein
Eco28_RS12335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Eco28_RS12340	COG1201	RNA secondary structure unwinding
Eco28_RS12350	COG0346	lactoylglutathione lyase activity
Eco28_RS12355	COG1902	pentaerythritol trinitrate reductase activity
Eco28_RS12360	COG1309	transcriptional regulator
Eco28_RS12365	COG3313	Fe-S protein
Eco28_RS12370	COG4989	oxidoreductase activity
Eco28_RS12375	COG2032	superoxide dismutase activity
Eco28_RS12380	COG1289	transmembrane transporter activity
Eco28_RS12385	COG1566	PFAM secretion protein HlyD family protein
Eco28_RS12400	COG3133	Outer membrane lipoprotein
Eco28_RS12410	COG3895	Periplasmic Protein
Eco28_RS12425	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Eco28_RS12430	COG0625	glutathione transferase activity
Eco28_RS12435	COG3104	oligopeptide transport
Eco28_RS12445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Eco28_RS12455	COG4659	FMN binding
Eco28_RS12510	COG0673	inositol 2-dehydrogenase activity
Eco28_RS12520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Eco28_RS12525	COG1263	PTS System
Eco28_RS12525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS12530	COG1609	Transcriptional regulator
Eco28_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS12540	COG1309	transcriptional regulator
Eco28_RS12545	COG3250	beta-galactosidase activity
Eco28_RS12560	COG5339	Protein conserved in bacteria
Eco28_RS12565	COG1482	cell wall glycoprotein biosynthetic process
Eco28_RS12570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS12570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS12575	COG0114	fumarate hydratase activity
Eco28_RS12585	COG2205	protein histidine kinase activity
Eco28_RS12590	COG0745	RESPONSE REGULATOR receiver
Eco28_RS12595	COG3136	membrane protein required for alginate biosynthesis
Eco28_RS12605	COG0531	amino acid
Eco28_RS12620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Eco28_RS12625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Eco28_RS12630	COG0628	permease
Eco28_RS12645	COG3591	Belongs to the peptidase S1B family
Eco28_RS12665	COG2814	Major facilitator Superfamily
Eco28_RS12670	COG0583	DNA-binding transcription factor activity
Eco28_RS12675	COG1940	carbohydrate kinase activity
Eco28_RS12680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Eco28_RS12690	COG3381	protein complex oligomerization
Eco28_RS12695	COG3302	dmso reductase anchor subunit
Eco28_RS12700	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS12705	COG0243	molybdopterin cofactor binding
Eco28_RS12710	COG0243	molybdopterin cofactor binding
Eco28_RS12725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Eco28_RS12745	COG4948	Mandelate Racemase Muconate Lactonizing
Eco28_RS12750	COG1063	alcohol dehydrogenase
Eco28_RS12760	COG0582	viral genome integration into host DNA
Eco28_RS12770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Eco28_RS12795	COG1396	sequence-specific DNA binding
Eco28_RS12810	COG1846	Transcriptional regulator
Eco28_RS12820	COG2801	Transposase and inactivated derivatives
Eco28_RS12835	COG3077	Addiction module antitoxin, RelB DinJ family
Eco28_RS12840	COG2026	Addiction module toxin, RelE StbE family
Eco28_RS12860	COG1403	HNH endonuclease
Eco28_RS12865	COG0484	heat shock protein binding
Eco28_RS12870	COG1278	Cold shock
Eco28_RS12875	COG1278	Cold shock
Eco28_RS12890	COG3772	lysozyme
Eco28_RS12900	COG1278	Cold shock
Eco28_RS12920	COG5562	phage envelope protein
Eco28_RS12930	COG4220	transposase activity
Eco28_RS12950	COG1030	water channel activity
Eco28_RS12965	COG0582	viral genome integration into host DNA
Eco28_RS13080	COG1196	nuclear chromosome segregation
Eco28_RS13115	COG5301	cellulose 1,4-beta-cellobiosidase activity
Eco28_RS13130	COG0840	transmembrane signaling receptor activity
Eco28_RS13135	COG5301	cellulose 1,4-beta-cellobiosidase activity
Eco28_RS13140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS13145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS13160	COG0477	Major facilitator Superfamily
Eco28_RS13165	COG0246	Mannitol dehydrogenase
Eco28_RS13175	COG1802	Transcriptional regulator
Eco28_RS13180	COG4221	oxidoreductase activity
Eco28_RS13190	COG0339	signal peptide processing
Eco28_RS13205	COG3111	PFAM Bacterial OB fold (BOF) protein
Eco28_RS13210	COG3706	GGDEF domain
Eco28_RS13220	COG2814	Major facilitator Superfamily
Eco28_RS13225	COG0697	spore germination
Eco28_RS13230	COG2188	Transcriptional regulator
Eco28_RS13240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Eco28_RS13245	COG1447	Phosphotransferase system cellobiose-specific component IIA
Eco28_RS13255	COG2723	6-phospho-beta-galactosidase activity
Eco28_RS13265	COG4977	sequence-specific DNA binding
Eco28_RS13270	COG1846	Transcriptional regulator
Eco28_RS13295	COG0583	DNA-binding transcription factor activity
Eco28_RS13300	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS13305	COG2066	Belongs to the glutaminase family
Eco28_RS13320	COG2199	diguanylate cyclase activity
Eco28_RS13340	COG3781	membrane
Eco28_RS13390	COG3210	domain, Protein
Eco28_RS13390	COG2911	Protein conserved in bacteria
Eco28_RS13395	COG1396	sequence-specific DNA binding
Eco28_RS13400	COG3550	peptidyl-serine autophosphorylation
Eco28_RS13405	COG4977	sequence-specific DNA binding
Eco28_RS13410	COG3539	Fimbrial protein
Eco28_RS13425	COG3188	usher protein
Eco28_RS13430	COG3539	Fimbrial protein
Eco28_RS13435	COG3539	Fimbrial protein
Eco28_RS13440	COG3539	Fimbrial protein
Eco28_RS13445	COG0243	molybdopterin cofactor binding
Eco28_RS13455	COG2207	Transcriptional regulator
Eco28_RS13460	COG3119	arylsulfatase activity
Eco28_RS13465	COG0641	radical SAM
Eco28_RS13470	COG4178	(ABC) transporter
Eco28_RS13475	COG4771	TonB-dependent receptor
Eco28_RS13480	COG0612	Peptidase, M16
Eco28_RS13490	COG0076	glutamate decarboxylase activity
Eco28_RS13495	COG0531	amino acid
Eco28_RS13500	COG1649	PFAM Uncharacterised BCR, COG1649
Eco28_RS13505	COG3706	GGDEF domain
Eco28_RS13510	COG2202	Pas domain
Eco28_RS13510	COG2199	diguanylate cyclase activity
Eco28_RS13510	COG2200	EAL domain
Eco28_RS13515	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Eco28_RS13520	COG0747	negative chemotaxis
Eco28_RS13525	COG0601	transmembrane transport
Eco28_RS13530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Eco28_RS13535	COG0444	Belongs to the ABC transporter superfamily
Eco28_RS13540	COG4608	Belongs to the ABC transporter superfamily
Eco28_RS13545	COG1764	response to oxidative stress
Eco28_RS13570	COG1064	alcohol dehydrogenase
Eco28_RS13575	COG3093	addiction module antidote protein HigA
Eco28_RS13580	COG2864	formate dehydrogenase
Eco28_RS13585	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS13595	COG0697	spore germination
Eco28_RS13610	COG4886	Leucine-rich repeat (LRR) protein
Eco28_RS13615	COG4886	Leucine-rich repeat (LRR) protein
Eco28_RS13620	COG2223	nitrite transmembrane transporter activity
Eco28_RS13625	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Eco28_RS13630	COG1140	nitrate reductase beta subunit
Eco28_RS13635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Eco28_RS13640	COG2181	nitrate reductase activity
Eco28_RS13645	COG0384	phenazine biosynthesis protein PhzF
Eco28_RS13650	COG2162	N-hydroxyarylamine O-acetyltransferase activity
Eco28_RS13655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Eco28_RS13665	COG5433	transposase activity
Eco28_RS13685	COG3209	COG3209 Rhs family protein
Eco28_RS13705	COG1113	amino acid transport
Eco28_RS13710	COG3391	amine dehydrogenase activity
Eco28_RS13725	COG4772	TonB-dependent receptor
Eco28_RS13740	COG1802	Transcriptional regulator
Eco28_RS13745	COG2130	NADP-dependent
Eco28_RS13755	COG1247	-acetyltransferase
Eco28_RS13760	COG3238	Protein conserved in bacteria
Eco28_RS13790	COG1177	transmembrane transport
Eco28_RS13795	COG1176	ABC-type spermidine putrescine transport system, permease component I
Eco28_RS13800	COG3842	ATPase activity
Eco28_RS13805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Eco28_RS13810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Eco28_RS13815	COG1598	PFAM Uncharacterised protein family UPF0150
Eco28_RS13820	COG1724	mRNA binding
Eco28_RS13830	COG0826	peptidase U32
Eco28_RS13835	COG1396	sequence-specific DNA binding
Eco28_RS13840	COG3135	benzoate transporter
Eco28_RS13845	COG0675	Transposase, IS605 OrfB family
Eco28_RS13860	COG0500	methyltransferase
Eco28_RS13865	COG1275	C4-dicarboxylate transporter malic acid transport protein
Eco28_RS13870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Eco28_RS13875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Eco28_RS13880	COG2841	Protein conserved in bacteria
Eco28_RS13900	COG5383	Protein conserved in bacteria
Eco28_RS13905	COG0583	DNA-binding transcription factor activity
Eco28_RS13910	COG0840	transmembrane signaling receptor activity
Eco28_RS13925	COG3038	cytochrome b561
Eco28_RS13930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Eco28_RS13935	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS13940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Eco28_RS13965	COG1643	Atp-dependent helicase
Eco28_RS13975	COG0671	phosphoesterase, PA-phosphatase related
Eco28_RS13975	COG2453	phosphatase
Eco28_RS13980	COG2267	carboxylic ester hydrolase activity
Eco28_RS13985	COG4589	Belongs to the CDS family
Eco28_RS13990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Eco28_RS14000	COG0667	Aldo Keto reductase
Eco28_RS14015	COG3784	Protein of unknown function (DUF1318)
Eco28_RS14025	COG2911	Protein conserved in bacteria
Eco28_RS14030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Eco28_RS14035	COG3187	Heat shock protein
Eco28_RS14040	COG3042	response to heat
Eco28_RS14045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Eco28_RS14045	COG1013	pyruvate-flavodoxin oxidoreductase activity
Eco28_RS14045	COG0674	pyruvate-flavodoxin oxidoreductase activity
Eco28_RS14045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Eco28_RS14055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Eco28_RS14060	COG0589	response to stress
Eco28_RS14070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS14075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS14080	COG5301	cellulose 1,4-beta-cellobiosidase activity
Eco28_RS14130	COG1196	nuclear chromosome segregation
Eco28_RS14210	COG1475	DNA binding
Eco28_RS14220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Eco28_RS14230	COG3772	lysozyme
Eco28_RS14250	COG3064	Membrane
Eco28_RS14285	COG2814	Major facilitator Superfamily
Eco28_RS14290	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Eco28_RS14310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Eco28_RS14375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Eco28_RS14380	COG3723	Recombinational DNA repair protein, rece pathway
Eco28_RS14400	COG0582	viral genome integration into host DNA
Eco28_RS14410	COG0513	Belongs to the DEAD box helicase family
Eco28_RS14425	COG3706	GGDEF domain
Eco28_RS14430	COG2840	Smr protein MutS2
Eco28_RS14440	COG0583	DNA-binding transcription factor activity
Eco28_RS14445	COG1473	amidohydrolase
Eco28_RS14450	COG1473	amidohydrolase
Eco28_RS14460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Eco28_RS14465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Eco28_RS14470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Eco28_RS14475	COG0589	response to stress
Eco28_RS14480	COG3182	Iron-regulated membrane protein
Eco28_RS14485	COG0668	transmembrane transport
Eco28_RS14490	COG4166	transmembrane transport
Eco28_RS14495	COG0583	DNA-binding transcription factor activity
Eco28_RS14500	COG1073	alpha beta
Eco28_RS14505	COG1073	alpha beta
Eco28_RS14510	COG0702	epimerase
Eco28_RS14515	COG2866	Carboxypeptidase
Eco28_RS14520	COG4948	Mandelate Racemase Muconate Lactonizing
Eco28_RS14525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Eco28_RS14530	COG3283	Transcriptional regulator of aromatic amino acids metabolism
Eco28_RS14540	COG3106	COG3106 Predicted ATPase
Eco28_RS14545	COG1609	Transcriptional regulator
Eco28_RS14555	COG3842	ATPase activity
Eco28_RS14560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Eco28_RS14565	COG1554	hydrolase, family 65, central catalytic
Eco28_RS14570	COG0673	inositol 2-dehydrogenase activity
Eco28_RS14575	COG1082	Xylose isomerase domain protein TIM barrel
Eco28_RS14580	COG1063	alcohol dehydrogenase
Eco28_RS14585	COG0395	ABC-type sugar transport system, permease component
Eco28_RS14590	COG1175	transmembrane transport
Eco28_RS14595	COG1653	transport
Eco28_RS14600	COG0366	Alpha amylase catalytic
Eco28_RS14605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Eco28_RS14615	COG1983	PspC domain protein
Eco28_RS14625	COG1842	Phage shock protein A
Eco28_RS14630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Eco28_RS14635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Eco28_RS14640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Eco28_RS14645	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS14650	COG1917	Cupin 2, conserved barrel domain protein
Eco28_RS14650	COG1396	sequence-specific DNA binding
Eco28_RS14655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Eco28_RS14660	COG0174	glutamine synthetase
Eco28_RS14665	COG0531	amino acid
Eco28_RS14680	COG4166	transmembrane transport
Eco28_RS14685	COG4168	peptide transport system, permease
Eco28_RS14690	COG4171	peptide transport system, permease
Eco28_RS14695	COG4172	Belongs to the ABC transporter superfamily
Eco28_RS14700	COG4172	Belongs to the ABC transporter superfamily
Eco28_RS14705	COG2814	Major facilitator Superfamily
Eco28_RS14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS14730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Eco28_RS14735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Eco28_RS14735	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Eco28_RS14750	COG5001	Diguanylate cyclase
Eco28_RS14760	COG1349	DNA-binding transcription factor activity
Eco28_RS14770	COG0023	Translation Initiation Factor
Eco28_RS14780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Eco28_RS14785	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Eco28_RS14790	COG0671	phosphoesterase, PA-phosphatase related
Eco28_RS14800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Eco28_RS14820	COG0583	DNA-binding transcription factor activity
Eco28_RS14840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Eco28_RS14855	COG0616	signal peptide processing
Eco28_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS14865	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Eco28_RS14870	COG1187	pseudouridine synthase activity
Eco28_RS14875	COG4907	membrane protein (DUF2207)
Eco28_RS14880	COG0009	L-threonylcarbamoyladenylate synthase
Eco28_RS14885	COG0613	PHP domain protein
Eco28_RS14890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Eco28_RS14895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Eco28_RS14895	COG0512	Glutamine amidotransferase of anthranilate synthase
Eco28_RS14900	COG0135	phosphoribosylanthranilate isomerase activity
Eco28_RS14900	COG0134	indole-3-glycerol-phosphate synthase activity
Eco28_RS14910	COG0159	tryptophan synthase activity
Eco28_RS14915	COG3729	General stress protein
Eco28_RS14920	COG3685	Protein conserved in bacteria
Eco28_RS14925	COG3685	Protein conserved in bacteria
Eco28_RS14930	COG3047	cAMP biosynthetic process
Eco28_RS14945	COG1607	acyl-coa hydrolase
Eco28_RS14950	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Eco28_RS14955	COG2350	Protein conserved in bacteria
Eco28_RS14960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Eco28_RS14980	COG4608	Belongs to the ABC transporter superfamily
Eco28_RS14985	COG0444	Belongs to the ABC transporter superfamily
Eco28_RS14990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Eco28_RS14995	COG0601	transmembrane transport
Eco28_RS15000	COG4166	transmembrane transport
Eco28_RS15010	COG2095	MarC family integral membrane protein
Eco28_RS15015	COG1454	alcohol dehydrogenase
Eco28_RS15015	COG1012	belongs to the aldehyde dehydrogenase family
Eco28_RS15030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Eco28_RS15035	COG0745	RESPONSE REGULATOR receiver
Eco28_RS15040	COG1752	Esterase of the alpha-beta hydrolase superfamily
Eco28_RS15050	COG0788	formyltetrahydrofolate deformylase activity
Eco28_RS15075	COG2181	nitrate reductase activity
Eco28_RS15080	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Eco28_RS15085	COG1140	nitrate reductase beta subunit
Eco28_RS15090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Eco28_RS15095	COG2223	nitrite transmembrane transporter activity
Eco28_RS15105	COG3850	Histidine kinase
Eco28_RS15110	COG2197	response regulator
Eco28_RS15115	COG4932	domain protein
Eco28_RS15120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Eco28_RS15125	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Eco28_RS15130	COG4572	Cation transport regulator
Eco28_RS15135	COG0387	Pfam Sodium calcium exchanger
Eco28_RS15165	COG2912	Transglutaminase-like superfamily
Eco28_RS15170	COG3094	Invasion gene expression up-regulator, SirB
Eco28_RS15175	COG2890	protein-(glutamine-N5) methyltransferase activity
Eco28_RS15200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Eco28_RS15205	COG0659	secondary active sulfate transmembrane transporter activity
Eco28_RS15220	COG0012	GTP binding
Eco28_RS15235	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS15240	COG3284	Transcriptional regulator
Eco28_RS15245	COG2376	Dihydroxyacetone kinase
Eco28_RS15250	COG1461	Dihydroxyacetone kinase
Eco28_RS15255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Eco28_RS15255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS15255	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Eco28_RS15275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Eco28_RS15280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Eco28_RS15285	COG1120	ATPase activity
Eco28_RS15290	COG0500	methyltransferase
Eco28_RS15295	COG0157	Belongs to the NadC ModD family
Eco28_RS15310	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Eco28_RS15325	COG1619	proteins homologs of microcin C7 resistance protein MccF
Eco28_RS15340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Eco28_RS15350	COG2719	SpoVR family
Eco28_RS15365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Eco28_RS15370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Eco28_RS15375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Eco28_RS15390	COG0179	Fumarylacetoacetate (FAA) hydrolase
Eco28_RS15425	COG2894	cell division
Eco28_RS15475	COG2200	EAL domain
Eco28_RS15500	COG2200	EAL domain
Eco28_RS15505	COG0789	Transcriptional regulator
Eco28_RS15510	COG5562	phage envelope protein
Eco28_RS15535	COG0538	isocitrate dehydrogenase activity
Eco28_RS15540	COG1187	pseudouridine synthase activity
Eco28_RS15560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Eco28_RS15570	COG2205	protein histidine kinase activity
Eco28_RS15575	COG2850	peptidyl-arginine hydroxylation
Eco28_RS15590	COG3842	ATPase activity
Eco28_RS15600	COG1177	transmembrane transport
Eco28_RS15605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Eco28_RS15610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Eco28_RS15620	COG4591	ABC-type transport system involved in lipoprotein release permease component
Eco28_RS15630	COG4591	ABC-type transport system involved in lipoprotein release permease component
Eco28_RS15635	COG4763	Acyl-transferase
Eco28_RS15640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Eco28_RS15645	COG1376	ErfK ybiS ycfS ynhG family protein
Eco28_RS15645	COG1388	LysM domain
Eco28_RS15655	COG1309	transcriptional regulator
Eco28_RS15660	COG3134	Outer membrane lipoprotein
Eco28_RS15670	COG1252	NADH dehydrogenase
Eco28_RS15690	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
Eco28_RS15695	COG5633	Lipoprotein
Eco28_RS15700	COG0537	adenosine 5'-monophosphoramidase activity
Eco28_RS15705	COG4773	Receptor
Eco28_RS15750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS15760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS15860	COG4695	Portal protein
Eco28_RS15900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Eco28_RS15940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Eco28_RS15950	COG4773	Receptor
Eco28_RS15955	COG1263	PTS System
Eco28_RS15955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS15960	COG0084	hydrolase, TatD family'
Eco28_RS15965	COG0470	DNA polymerase III
Eco28_RS15975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Eco28_RS15980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Eco28_RS15985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Eco28_RS15995	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS16000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Eco28_RS16020	COG1399	metal-binding, possibly nucleic acid-binding protein
Eco28_RS16025	COG0424	maF-like protein
Eco28_RS16030	COG0564	pseudouridine synthase activity
Eco28_RS16040	COG1530	ribonuclease E activity
Eco28_RS16045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Eco28_RS16050	COG1256	bacterial-type flagellum assembly
Eco28_RS16055	COG1705	Flagellar rod assembly protein muramidase FlgJ
Eco28_RS16055	COG3951	Flagellar rod assembly protein muramidase FlgJ
Eco28_RS16070	COG4786	Flagellar basal body rod
Eco28_RS16075	COG4787	bacterial-type flagellum-dependent cell motility
Eco28_RS16080	COG1749	Flagellar hook protein flgE
Eco28_RS16085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Eco28_RS16090	COG1558	bacterial-type flagellum-dependent cell motility
Eco28_RS16095	COG1815	bacterial-type flagellum-dependent cell motility
Eco28_RS16100	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Eco28_RS16105	COG2747	anti-sigma28 factor FlgM
Eco28_RS16110	COG3418	PFAM FlgN family protein
Eco28_RS16115	COG0728	peptidoglycan biosynthetic process
Eco28_RS16120	COG0673	inositol 2-dehydrogenase activity
Eco28_RS16130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Eco28_RS16140	COG2999	glutathione oxidoreductase activity
Eco28_RS16175	COG3038	cytochrome b561
Eco28_RS16180	COG2353	YceI-like domain
Eco28_RS16190	COG1560	Kdo2-lipid A biosynthetic process
Eco28_RS16205	COG5645	(Lipo)protein
Eco28_RS16210	COG2943	transferase activity, transferring hexosyl groups
Eco28_RS16235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Eco28_RS16240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS16275	COG2197	response regulator
Eco28_RS16290	COG1462	curli production assembly transport component CsgG
Eco28_RS16300	COG3381	protein complex oligomerization
Eco28_RS16355	COG2003	Belongs to the UPF0758 family
Eco28_RS16395	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS16600	COG4983	Phage plasmid primase, P4 family domain protein
Eco28_RS16630	COG0582	viral genome integration into host DNA
Eco28_RS16685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Eco28_RS16690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Eco28_RS16700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Eco28_RS16710	COG0736	holo-[acyl-carrier-protein] synthase activity
Eco28_RS16715	COG2831	hemolysin activation secretion protein
Eco28_RS16720	COG3210	domain, Protein
Eco28_RS16730	COG3539	Fimbrial protein
Eco28_RS16740	COG3188	usher protein
Eco28_RS16750	COG3121	Chaperone
Eco28_RS16755	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS16770	COG2200	EAL domain
Eco28_RS16775	COG3706	GGDEF domain
Eco28_RS16785	COG0457	Tetratricopeptide repeat
Eco28_RS16790	COG1649	PFAM Uncharacterised BCR, COG1649
Eco28_RS16790	COG0726	polysaccharide deacetylase
Eco28_RS16795	COG1215	transferase activity, transferring glycosyl groups
Eco28_RS16800	COG3658	cytochrome
Eco28_RS16805	COG1702	phosphate starvation-inducible protein PhoH
Eco28_RS16835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Eco28_RS16850	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Eco28_RS16850	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Eco28_RS16850	COG0506	proline dehydrogenase activity
Eco28_RS16855	COG1309	transcriptional regulator
Eco28_RS16890	COG2233	PERMEase
Eco28_RS16895	COG3729	General stress protein
Eco28_RS16940	COG0243	molybdopterin cofactor binding
Eco28_RS16945	COG3005	denitrification pathway
Eco28_RS16950	COG0745	RESPONSE REGULATOR receiver
Eco28_RS16955	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS16960	COG0784	Response regulator, receiver
Eco28_RS16960	COG2198	Histidine kinase
Eco28_RS16960	COG2205	protein histidine kinase activity
Eco28_RS16965	COG0348	domain, Protein
Eco28_RS16985	COG1278	Cold shock
Eco28_RS16990	COG1278	Cold shock
Eco28_RS17020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Eco28_RS17025	COG1596	polysaccharide export
Eco28_RS17030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Eco28_RS17035	COG0489	protein tyrosine kinase activity
Eco28_RS17035	COG3206	protein involved in exopolysaccharide biosynthesis
Eco28_RS17050	COG1294	oxidase, subunit
Eco28_RS17055	COG1271	oxidase subunit
Eco28_RS17060	COG1773	rubredoxin
Eco28_RS17065	COG1999	signal sequence binding
Eco28_RS17070	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Eco28_RS17075	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
Eco28_RS17080	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Eco28_RS17085	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Eco28_RS17095	COG0670	Belongs to the BI1 family
Eco28_RS17100	COG2920	part of a sulfur-relay system
Eco28_RS17105	COG1254	Belongs to the acylphosphatase family
Eco28_RS17120	COG1832	CoA-binding protein
Eco28_RS17135	COG0210	DNA helicase
Eco28_RS17140	COG3304	Inner membrane component domain
Eco28_RS17145	COG1289	transmembrane transporter activity
Eco28_RS17150	COG3070	regulator of competence-specific genes
Eco28_RS17175	COG1067	ATP-dependent peptidase activity
Eco28_RS17185	COG3130	regulation of translation
Eco28_RS17190	COG3009	Protein conserved in bacteria
Eco28_RS17195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Eco28_RS17195	COG3008	intermembrane lipid transfer
Eco28_RS17200	COG2995	paraquat-inducible protein a
Eco28_RS17205	COG0488	(ABC) transporter
Eco28_RS17215	COG3217	Mosc domain protein beta barrel domain protein
Eco28_RS17215	COG0633	Ferredoxin
Eco28_RS17230	COG3121	Chaperone
Eco28_RS17235	COG3539	Fimbrial protein
Eco28_RS17240	COG3539	Fimbrial protein
Eco28_RS17250	COG3188	usher protein
Eco28_RS17265	COG3121	Chaperone
Eco28_RS17270	COG3539	Fimbrial protein
Eco28_RS17280	COG0431	NADPH-dependent FMN reductase
Eco28_RS17285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Eco28_RS17295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Eco28_RS17300	COG1116	anion transmembrane transporter activity
Eco28_RS17305	COG0308	aminopeptidase N
Eco28_RS17330	COG1448	Aminotransferase
Eco28_RS17335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Eco28_RS17340	COG3108	Peptidase M15
Eco28_RS17350	COG2989	Protein conserved in bacteria
Eco28_RS17360	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Eco28_RS17370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Eco28_RS17375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Eco28_RS17380	COG3173	Aminoglycoside phosphotransferase
Eco28_RS17395	COG3214	Protein conserved in bacteria
Eco28_RS17405	COG1132	(ABC) transporter
Eco28_RS17410	COG0658	competence protein
Eco28_RS17410	COG2333	competence protein COMEC
Eco28_RS17420	COG0539	negative regulation of cytoplasmic translation
Eco28_RS17435	COG0501	Belongs to the peptidase M48B family
Eco28_RS17450	COG2323	membrane
Eco28_RS17455	COG1944	ATP diphosphatase activity
Eco28_RS17460	COG2116	formate transmembrane transporter activity
Eco28_RS17465	COG1882	Formate acetyltransferase
Eco28_RS17470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Eco28_RS17475	COG0583	DNA-binding transcription factor activity
Eco28_RS17480	COG0531	amino acid
Eco28_RS17490	COG0531	amino acid
Eco28_RS17500	COG1335	isochorismatase
Eco28_RS17505	COG3302	dmso reductase anchor subunit
Eco28_RS17510	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS17515	COG0243	molybdopterin cofactor binding
Eco28_RS17525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Eco28_RS17535	COG1674	ftsk spoiiie
Eco28_RS17535	COG1178	ABC-type Fe3 transport system permease component
Eco28_RS17540	COG1522	sequence-specific DNA binding
Eco28_RS17550	COG0492	ferredoxin-NADP+ reductase activity
Eco28_RS17555	COG4988	ABC transporter
Eco28_RS17560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Eco28_RS17620	COG2003	Belongs to the UPF0758 family
Eco28_RS17640	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS17715	COG1358	cellular component organization or biogenesis
Eco28_RS17800	COG0582	viral genome integration into host DNA
Eco28_RS17805	COG0542	response to heat
Eco28_RS17815	COG1278	Cold shock
Eco28_RS17820	COG0577	efflux transmembrane transporter activity
Eco28_RS17820	COG1136	(ABC) transporter
Eco28_RS17825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS17830	COG2990	Protein conserved in bacteria
Eco28_RS17835	COG3593	DNA synthesis involved in DNA repair
Eco28_RS17840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Eco28_RS17850	COG2431	L-lysine efflux transmembrane transporter activity
Eco28_RS17860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Eco28_RS17865	COG0028	Belongs to the TPP enzyme family
Eco28_RS17870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Eco28_RS17875	COG0702	epimerase
Eco28_RS17880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Eco28_RS17885	COG3023	N-Acetylmuramoyl-L-alanine amidase
Eco28_RS17915	COG1126	abc transporter atp-binding protein
Eco28_RS17920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS17925	COG4215	(ABC) transporter
Eco28_RS17930	COG4160	amino acid transport
Eco28_RS17935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS17965	COG1177	transmembrane transport
Eco28_RS17970	COG1176	ABC-type spermidine putrescine transport system, permease component I
Eco28_RS17975	COG3842	ATPase activity
Eco28_RS17980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Eco28_RS18000	COG0778	Nitroreductase
Eco28_RS18010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Eco28_RS18030	COG3226	Transcriptional regulator
Eco28_RS18035	COG0738	Major facilitator superfamily
Eco28_RS18040	COG0561	phosphatase activity
Eco28_RS18050	COG2814	Major facilitator Superfamily
Eco28_RS18055	COG0671	phosphoesterase, PA-phosphatase related
Eco28_RS18060	COG1349	DNA-binding transcription factor activity
Eco28_RS18065	COG1686	Belongs to the peptidase S11 family
Eco28_RS18070	COG0625	glutathione transferase activity
Eco28_RS18075	COG2133	pyrroloquinoline quinone binding
Eco28_RS18100	COG2199	diguanylate cyclase activity
Eco28_RS18105	COG2200	EAL domain
Eco28_RS18115	COG2200	EAL domain
Eco28_RS18130	COG0747	negative chemotaxis
Eco28_RS18135	COG4172	Belongs to the ABC transporter superfamily
Eco28_RS18140	COG1446	asparaginase
Eco28_RS18145	COG0303	'Molybdopterin
Eco28_RS18150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Eco28_RS18155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Eco28_RS18160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Eco28_RS18165	COG1882	Formate acetyltransferase
Eco28_RS18170	COG0561	phosphatase activity
Eco28_RS18180	COG0488	(ABC) transporter
Eco28_RS18185	COG1376	ErfK ybiS ycfS ynhG family protein
Eco28_RS18190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Eco28_RS18195	COG1321	iron dependent repressor
Eco28_RS18205	COG2194	sulfuric ester hydrolase activity
Eco28_RS18210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Eco28_RS18215	COG5006	permease, DMT superfamily
Eco28_RS18235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS18240	COG0765	amino acid transport
Eco28_RS18245	COG1126	abc transporter atp-binding protein
Eco28_RS18250	COG0668	transmembrane transport
Eco28_RS18265	COG4774	siderophore transport
Eco28_RS18275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Eco28_RS18285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Eco28_RS18290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Eco28_RS18295	COG1199	ATP-dependent helicase activity
Eco28_RS18320	COG0513	Belongs to the DEAD box helicase family
Eco28_RS18325	COG1309	transcriptional regulator
Eco28_RS18335	COG1131	(ABC) transporter
Eco28_RS18340	COG0842	Transport permease protein
Eco28_RS18345	COG0842	Transport permease protein
Eco28_RS18355	COG3568	Endonuclease Exonuclease Phosphatase
Eco28_RS18360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Eco28_RS18365	COG0392	lysyltransferase activity
Eco28_RS18370	COG0670	Belongs to the BI1 family
Eco28_RS18375	COG0670	Belongs to the BI1 family
Eco28_RS18380	COG0314	molybdopterin synthase activity
Eco28_RS18385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Eco28_RS18395	COG0521	Mo-molybdopterin cofactor biosynthetic process
Eco28_RS18405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Eco28_RS18415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Eco28_RS18420	COG2226	methyltransferase
Eco28_RS18435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Eco28_RS18440	COG1881	PFAM PEBP family protein
Eco28_RS18450	COG4677	pectinesterase activity
Eco28_RS18455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Eco28_RS18460	COG0471	metal ion transport
Eco28_RS18465	COG2828	Protein conserved in bacteria
Eco28_RS18470	COG0583	DNA-binding transcription factor activity
Eco28_RS18480	COG0561	phosphatase activity
Eco28_RS18490	COG4149	molybdate abc transporter
Eco28_RS18495	COG0725	ABC transporter, periplasmic molybdate-binding protein
Eco28_RS18510	COG3585	molybdate ion transport
Eco28_RS18510	COG2005	Transcriptional regulator
Eco28_RS18515	COG1119	ATPase activity
Eco28_RS18520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Eco28_RS18525	COG1085	galactose-1-phosphate uridylyltransferase
Eco28_RS18535	COG2017	converts alpha-aldose to the beta-anomer
Eco28_RS18545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Eco28_RS18560	COG1230	cation diffusion facilitator family transporter
Eco28_RS18565	COG3201	nicotinamide mononucleotide transporter
Eco28_RS18605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Eco28_RS18610	COG2885	chlorophyll binding
Eco28_RS18620	COG3064	Membrane
Eco28_RS18625	COG0848	biopolymer transport protein
Eco28_RS18630	COG0811	peptide transport
Eco28_RS18635	COG0824	Thioesterase
Eco28_RS18640	COG3790	cyd operon protein YbgE
Eco28_RS18645	COG4890	Cyd operon protein YbgT
Eco28_RS18650	COG1294	oxidase, subunit
Eco28_RS18655	COG1271	oxidase subunit
Eco28_RS18675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Eco28_RS18685	COG4865	methylaspartate mutase activity
Eco28_RS18690	COG3799	methylaspartate ammonia-lyase activity
Eco28_RS18705	COG1301	dicarboxylic acid transport
Eco28_RS18710	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS18710	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS18715	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Eco28_RS18720	COG0583	DNA-binding transcription factor activity
Eco28_RS18735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Eco28_RS18745	COG0508	dehydrogenase complex catalyzes the overall conversion of
Eco28_RS18750	COG0567	Dehydrogenase, E1 component
Eco28_RS18755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Eco28_RS18760	COG1053	succinate dehydrogenase
Eco28_RS18765	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Eco28_RS18770	COG2009	succinate dehydrogenase
Eco28_RS18785	COG0372	Belongs to the citrate synthase family
Eco28_RS18790	COG3539	Fimbrial protein
Eco28_RS18795	COG3188	usher protein
Eco28_RS18800	COG3121	Chaperone
Eco28_RS18805	COG3539	Fimbrial protein
Eco28_RS18810	COG3180	Ammonia monooxygenase
Eco28_RS18815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Eco28_RS18825	COG1984	allophanate hydrolase subunit 2
Eco28_RS18830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Eco28_RS18835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Eco28_RS18845	COG0415	Belongs to the DNA photolyase family
Eco28_RS18850	COG3272	Protein of unknown function (DUF1722)
Eco28_RS18880	COG2205	protein histidine kinase activity
Eco28_RS18885	COG0745	RESPONSE REGULATOR receiver
Eco28_RS18895	COG0033	Phosphoglucomutase
Eco28_RS18900	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Eco28_RS18905	COG0596	Alpha beta hydrolase
Eco28_RS18915	COG0716	FMN binding
Eco28_RS18925	COG0735	belongs to the Fur family
Eco28_RS18945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS18945	COG1263	PTS System
Eco28_RS18945	COG2190	(PTS) system
Eco28_RS18955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Eco28_RS18960	COG1940	carbohydrate kinase activity
Eco28_RS18960	COG1846	Transcriptional regulator
Eco28_RS18965	COG0647	UMP catabolic process
Eco28_RS18975	COG0367	asparagine synthase
Eco28_RS19020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Eco28_RS19035	COG1702	phosphate starvation-inducible protein PhoH
Eco28_RS19045	COG4535	Mg2 and Co2 transporter CorC
Eco28_RS19050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Eco28_RS19055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Eco28_RS19060	COG0765	amino acid transport
Eco28_RS19065	COG0765	amino acid transport
Eco28_RS19070	COG1126	abc transporter atp-binding protein
Eco28_RS19080	COG0443	Heat shock 70 kDa protein
Eco28_RS19085	COG2214	Heat shock protein DnaJ domain protein
Eco28_RS19095	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Eco28_RS19100	COG2214	Heat shock protein DnaJ domain protein
Eco28_RS19110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Eco28_RS19115	COG2888	peptidyl-tyrosine sulfation
Eco28_RS19130	COG1466	dna polymerase III delta subunit
Eco28_RS19140	COG0406	alpha-ribazole phosphatase activity
Eco28_RS19145	COG0799	negative regulation of ribosome biogenesis
Eco28_RS19155	COG0768	penicillin binding
Eco28_RS19160	COG0772	Belongs to the SEDS family
Eco28_RS19165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Eco28_RS19170	COG1686	Belongs to the peptidase S11 family
Eco28_RS19190	COG0583	DNA-binding transcription factor activity
Eco28_RS19205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Eco28_RS19210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Eco28_RS19235	COG3069	C4-dicarboxylate transmembrane transporter activity
Eco28_RS19240	COG4565	transcriptional regulatory protein
Eco28_RS19245	COG3290	protein histidine kinase activity
Eco28_RS19255	COG3290	protein histidine kinase activity
Eco28_RS19260	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Eco28_RS19270	COG2301	Belongs to the HpcH HpaI aldolase family
Eco28_RS19275	COG3051	citrate lyase alpha subunit
Eco28_RS19290	COG0471	metal ion transport
Eco28_RS19295	COG3719	Belongs to the RNase T2 family
Eco28_RS19305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Eco28_RS19315	COG1063	alcohol dehydrogenase
Eco28_RS19320	COG0589	response to stress
Eco28_RS19325	COG3634	alkyl hydroperoxide reductase activity
Eco28_RS19335	COG0450	alkyl hydroperoxide reductase
Eco28_RS19340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Eco28_RS19350	COG0583	DNA-binding transcription factor activity
Eco28_RS19355	COG3969	phosphoadenosine phosphosulfate
Eco28_RS19360	COG1475	DNA binding
Eco28_RS19365	COG0436	Aminotransferase
Eco28_RS19370	COG0371	Dehydrogenase
Eco28_RS19375	COG2879	small protein
Eco28_RS19380	COG1966	Carbon starvation protein
Eco28_RS19385	COG2050	protein possibly involved in aromatic compounds catabolism
Eco28_RS19390	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS19395	COG3433	isochorismatase activity
Eco28_RS19395	COG1535	isochorismatase
Eco28_RS19400	COG1021	2,3-dihydroxybenzoate-AMP ligase
Eco28_RS19405	COG1169	isochorismate synthase
Eco28_RS19410	COG4592	Periplasmic binding protein
Eco28_RS19420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Eco28_RS19425	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Eco28_RS19430	COG1120	ATPase activity
Eco28_RS19435	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Eco28_RS19440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Eco28_RS19440	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
Eco28_RS19445	COG3251	PFAM MbtH domain protein
Eco28_RS19450	COG2382	esterase
Eco28_RS19455	COG4771	TonB-dependent receptor
Eco28_RS19460	COG2977	Belongs to the P-Pant transferase superfamily
Eco28_RS19500	COG2315	Protein conserved in bacteria
Eco28_RS19505	COG0778	Nitroreductase
Eco28_RS19510	COG0668	transmembrane transport
Eco28_RS19515	COG1113	amino acid transport
Eco28_RS19520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Eco28_RS19525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS19530	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS19535	COG1538	Outer membrane efflux protein
Eco28_RS19545	COG0745	RESPONSE REGULATOR receiver
Eco28_RS19550	COG5002	protein histidine kinase activity
Eco28_RS19565	COG4104	PAAR repeat-containing protein
Eco28_RS19565	COG3209	COG3209 Rhs family protein
Eco28_RS19575	COG3209	COG3209 Rhs family protein
Eco28_RS19575	COG4104	PAAR repeat-containing protein
Eco28_RS19595	COG5433	transposase activity
Eco28_RS19600	COG1215	transferase activity, transferring glycosyl groups
Eco28_RS19605	COG4783	chaperone-mediated protein folding
Eco28_RS19620	COG2207	Transcriptional regulator
Eco28_RS19635	COG2197	response regulator
Eco28_RS19640	COG3539	Fimbrial protein
Eco28_RS19645	COG3539	Fimbrial protein
Eco28_RS19650	COG3188	usher protein
Eco28_RS19655	COG3121	Chaperone
Eco28_RS19665	COG3039	Transposase
Eco28_RS19670	COG3121	Chaperone
Eco28_RS19675	COG3539	Fimbrial protein
Eco28_RS19685	COG2501	S4 domain
Eco28_RS19690	COG1988	membrane-bound metal-dependent
Eco28_RS19700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Eco28_RS19715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Eco28_RS19720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Eco28_RS19725	COG0549	Belongs to the carbamate kinase family
Eco28_RS19735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Eco28_RS19740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Eco28_RS19745	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Eco28_RS19750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Eco28_RS19755	COG3257	ureidoglycine aminohydrolase activity
Eco28_RS19760	COG1929	Belongs to the glycerate kinase type-1 family
Eco28_RS19765	COG2233	PERMEase
Eco28_RS19775	COG1953	Uracil, thiamine, allantoin
Eco28_RS19780	COG2084	Dehydrogenase
Eco28_RS19785	COG3622	Belongs to the hyi family
Eco28_RS19790	COG3960	tartronate-semialdehyde synthase activity
Eco28_RS19795	COG1414	Transcriptional regulator
Eco28_RS19805	COG0583	DNA-binding transcription factor activity
Eco28_RS19815	COG2801	Transposase and inactivated derivatives
Eco28_RS19825	COG3209	COG3209 Rhs family protein
Eco28_RS19830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Eco28_RS19835	COG4181	ATPase activity
Eco28_RS19840	COG2755	lipolytic protein G-D-S-L family
Eco28_RS19845	COG0300	oxidoreductase activity
Eco28_RS19850	COG3118	belongs to the thioredoxin family
Eco28_RS19855	COG0390	transport system, permease component
Eco28_RS19860	COG4619	ABC transporter
Eco28_RS19865	COG0330	HflC and HflK could
Eco28_RS19870	COG1585	Membrane protein implicated in regulation of membrane protease activity
Eco28_RS19900	COG0789	Transcriptional regulator
Eco28_RS19925	COG0531	amino acid
Eco28_RS19935	COG2217	Heavy metal translocating P-type atpase
Eco28_RS19940	COG3093	addiction module antidote protein HigA
Eco28_RS19945	COG3735	TraB family
Eco28_RS19955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Eco28_RS19960	COG0737	Belongs to the 5'-nucleotidase family
Eco28_RS19970	COG2223	nitrite transmembrane transporter activity
Eco28_RS19975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Eco28_RS19975	COG4651	solute:proton antiporter activity
Eco28_RS19980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS20020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Eco28_RS20035	COG2832	Protein of unknown function (DUF454)
Eco28_RS20040	COG3923	Primosomal replication protein n
Eco28_RS20050	COG3264	Mechanosensitive ion channel
Eco28_RS20050	COG1196	nuclear chromosome segregation
Eco28_RS20065	COG3039	Transposase
Eco28_RS20070	COG1309	transcriptional regulator
Eco28_RS20075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Eco28_RS20080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Eco28_RS20095	COG0110	maltose O-acetyltransferase activity
Eco28_RS20105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Eco28_RS20110	COG5507	3-demethylubiquinone-9 3-methyltransferase
Eco28_RS20120	COG3695	enzyme binding
Eco28_RS20125	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Eco28_RS20130	COG1946	Acyl-CoA thioesterase
Eco28_RS20135	COG0004	ammonium transporteR
Eco28_RS20140	COG0347	Belongs to the P(II) protein family
Eco28_RS20145	COG1132	(ABC) transporter
Eco28_RS20150	COG1132	(ABC) transporter
Eco28_RS20155	COG1522	sequence-specific DNA binding
Eco28_RS20165	COG4533	DNA binding
Eco28_RS20175	COG0824	Thioesterase
Eco28_RS20180	COG1555	photosystem II stabilization
Eco28_RS20185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Eco28_RS20190	COG0776	regulation of translation
Eco28_RS20195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Eco28_RS20220	COG0271	Belongs to the BolA IbaG family
Eco28_RS20230	COG3056	Lipoprotein
Eco28_RS20235	COG2223	nitrite transmembrane transporter activity
Eco28_RS20240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Eco28_RS20245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Eco28_RS20250	COG1845	cytochrome c oxidase, subunit III
Eco28_RS20255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Eco28_RS20265	COG2814	Major facilitator Superfamily
Eco28_RS20275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Eco28_RS20280	COG0693	protein deglycase activity
Eco28_RS20300	COG0142	geranyltranstransferase activity
Eco28_RS20310	COG0667	Aldo Keto reductase
Eco28_RS20320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Eco28_RS20325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Eco28_RS20340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Eco28_RS20340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Eco28_RS20350	COG4238	major outer membrane lipoprotein
Eco28_RS20355	COG3248	Nucleoside-binding outer membrane protein
Eco28_RS20360	COG1403	HNH endonuclease
Eco28_RS20365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Eco28_RS20370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Eco28_RS20375	COG1862	Preprotein translocase
Eco28_RS20400	COG0366	Alpha amylase catalytic
Eco28_RS20405	COG1113	amino acid transport
Eco28_RS20410	COG1114	Component of the transport system for branched-chain amino acids
Eco28_RS20415	COG5002	protein histidine kinase activity
Eco28_RS20420	COG0745	RESPONSE REGULATOR receiver
Eco28_RS20425	COG0420	3'-5' exonuclease activity
Eco28_RS20430	COG0419	ATPase involved in DNA repair
Eco28_RS20435	COG2814	Major facilitator Superfamily
Eco28_RS20440	COG1940	carbohydrate kinase activity
Eco28_RS20465	COG4126	flavin adenine dinucleotide binding
Eco28_RS20490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Eco28_RS20495	COG3706	GGDEF domain
Eco28_RS20505	COG1785	Belongs to the alkaline phosphatase family
Eco28_RS20520	COG1181	Belongs to the D-alanine--D-alanine ligase family
Eco28_RS20540	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
Eco28_RS20550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Eco28_RS20555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Eco28_RS20560	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS20575	COG0113	porphobilinogen synthase activity
Eco28_RS20580	COG2175	clavaminate synthase activity
Eco28_RS20585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Eco28_RS20595	COG4521	taurine ABC transporter
Eco28_RS20610	COG2271	Major facilitator Superfamily
Eco28_RS20615	COG1840	ABC-type Fe3 transport system, periplasmic component
Eco28_RS20625	COG3842	ATPase activity
Eco28_RS20645	COG3122	Protein conserved in bacteria
Eco28_RS20650	COG2814	Major facilitator Superfamily
Eco28_RS20655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Eco28_RS20670	COG0596	Alpha beta hydrolase
Eco28_RS20690	COG1414	Transcriptional regulator
Eco28_RS20695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Eco28_RS20705	COG1609	Transcriptional regulator
Eco28_RS20720	COG2223	nitrite transmembrane transporter activity
Eco28_RS20725	COG0110	maltose O-acetyltransferase activity
Eco28_RS20730	COG2807	transmembrane transport
Eco28_RS20740	COG0288	reversible hydration of carbon dioxide
Eco28_RS20745	COG0583	DNA-binding transcription factor activity
Eco28_RS20750	COG0402	S-adenosylhomocysteine deaminase activity
Eco28_RS20755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Eco28_RS20760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Eco28_RS20765	COG2079	MmgE PrpD family protein
Eco28_RS20770	COG0372	Belongs to the citrate synthase family
Eco28_RS20775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Eco28_RS20780	COG3829	transcription factor binding
Eco28_RS20790	COG1280	lysine exporter protein (LysE YggA)
Eco28_RS20805	COG1064	alcohol dehydrogenase
Eco28_RS20815	COG1172	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS20820	COG1129	ABC transporter
Eco28_RS20825	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS20835	COG0402	S-adenosylhomocysteine deaminase activity
Eco28_RS20840	COG0549	Belongs to the carbamate kinase family
Eco28_RS20850	COG1304	FMN binding
Eco28_RS20855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Eco28_RS20865	COG0666	response to abiotic stimulus
Eco28_RS20880	COG0583	DNA-binding transcription factor activity
Eco28_RS20885	COG2771	luxR family
Eco28_RS20885	COG2200	EAL domain
Eco28_RS20895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Eco28_RS20935	COG2200	EAL domain
Eco28_RS20935	COG2771	luxR family
Eco28_RS20945	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS20965	COG1556	Lactate utilization protein
Eco28_RS20970	COG1139	Iron-sulfur cluster binding protein
Eco28_RS20975	COG0247	lactate metabolic process
Eco28_RS20980	COG2207	Transcriptional regulator
Eco28_RS20985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Eco28_RS20995	COG3059	membrane
Eco28_RS21005	COG3708	Transcriptional regulator
Eco28_RS21005	COG2207	Transcriptional regulator
Eco28_RS21010	COG1388	LysM domain
Eco28_RS21015	COG0656	L-ascorbic acid biosynthetic process
Eco28_RS21020	COG0667	Aldo Keto reductase
Eco28_RS21030	COG0583	DNA-binding transcription factor activity
Eco28_RS21035	COG1073	alpha beta
Eco28_RS21040	COG1902	pentaerythritol trinitrate reductase activity
Eco28_RS21090	COG3188	usher protein
Eco28_RS21105	COG0727	PFAM Uncharacterised protein family (UPF0153)
Eco28_RS21110	COG3477	response to acidic pH
Eco28_RS21120	COG2080	2 iron, 2 sulfur cluster binding
Eco28_RS21125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Eco28_RS21130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Eco28_RS21135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Eco28_RS21140	COG0583	DNA-binding transcription factor activity
Eco28_RS21175	COG2003	Belongs to the UPF0758 family
Eco28_RS21195	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS21220	COG1002	Type II restriction enzyme, methylase subunits
Eco28_RS21225	COG3039	Transposase
Eco28_RS21230	COG1002	Type II restriction enzyme, methylase subunits
Eco28_RS21235	COG1061	Type III restriction enzyme res subunit
Eco28_RS21240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Eco28_RS21265	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Eco28_RS21290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS21325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Eco28_RS21335	COG0583	DNA-binding transcription factor activity
Eco28_RS21350	COG2271	Major facilitator Superfamily
Eco28_RS21360	COG0800	Aldolase
Eco28_RS21365	COG3734	2-keto-3-deoxy-galactonokinase
Eco28_RS21370	COG2186	Transcriptional regulator
Eco28_RS21405	COG3436	PFAM IS66 Orf2 family protein
Eco28_RS21410	COG4372	Transposase
Eco28_RS21415	COG0477	Major facilitator Superfamily
Eco28_RS21430	COG1285	pathogenesis
Eco28_RS21450	COG1446	asparaginase
Eco28_RS21465	COG0675	Transposase, IS605 OrfB family
Eco28_RS21470	COG3069	C4-dicarboxylate transmembrane transporter activity
Eco28_RS21475	COG2195	Cleaves the N-terminal amino acid of tripeptides
Eco28_RS21485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Eco28_RS21490	COG0252	asparaginase activity
Eco28_RS21495	COG4565	transcriptional regulatory protein
Eco28_RS21525	COG4983	Phage plasmid primase, P4 family domain protein
Eco28_RS21530	COG4983	Phage plasmid primase, P4 family domain protein
Eco28_RS21565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Eco28_RS21585	COG2195	Cleaves the N-terminal amino acid of tripeptides
Eco28_RS21590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Eco28_RS21595	COG1690	Belongs to the RtcB family
Eco28_RS21600	COG0454	-acetyltransferase
Eco28_RS21605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Eco28_RS21620	COG1943	Transposase
Eco28_RS21630	COG0791	NLP P60 protein
Eco28_RS21635	COG3077	Addiction module antitoxin, RelB DinJ family
Eco28_RS21640	COG3041	Addiction module toxin RelE StbE family
Eco28_RS21645	COG3034	peptidoglycan biosynthetic process
Eco28_RS21650	COG0121	glutamine amidotransferase
Eco28_RS21660	COG1960	acyl-CoA dehydrogenase activity
Eco28_RS21670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Eco28_RS21675	COG5433	transposase activity
Eco28_RS21690	COG3436	PFAM IS66 Orf2 family protein
Eco28_RS21695	COG4372	Transposase
Eco28_RS21835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Eco28_RS21845	COG2226	methyltransferase
Eco28_RS21855	COG0741	lytic transglycosylase activity
Eco28_RS21855	COG1388	LysM domain
Eco28_RS21860	COG2226	methyltransferase
Eco28_RS21870	COG0583	DNA-binding transcription factor activity
Eco28_RS21875	COG0656	L-ascorbic acid biosynthetic process
Eco28_RS21910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Eco28_RS21915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Eco28_RS21920	COG2011	ABC-type metal ion transport system permease component
Eco28_RS21925	COG1464	Belongs to the NlpA lipoprotein family
Eco28_RS21935	COG1720	tRNA m6t6A37 methyltransferase activity
Eco28_RS21945	COG0791	NLP P60 protein
Eco28_RS21950	COG3015	lipoprotein NlpE involved in copper resistance
Eco28_RS21955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Eco28_RS21960	COG4681	YaeQ
Eco28_RS21970	COG4568	rho-dependent transcription termination
Eco28_RS21975	COG0037	tRNA processing
Eco28_RS21980	COG0346	lactoylglutathione lyase activity
Eco28_RS21985	COG1982	Orn Lys Arg decarboxylase major
Eco28_RS21995	COG0587	DNA-directed DNA polymerase activity
Eco28_RS22020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Eco28_RS22025	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Eco28_RS22035	COG0750	zinc metalloprotease
Eco28_RS22040	COG0575	Belongs to the CDS family
Eco28_RS22045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Eco28_RS22050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Eco28_RS22085	COG0024	Methionine aminopeptidase
Eco28_RS22105	COG3835	regulator
Eco28_RS22110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Eco28_RS22130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Eco28_RS22135	COG2860	membrane
Eco28_RS22155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Eco28_RS22160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Eco28_RS22165	COG1120	ATPase activity
Eco28_RS22170	COG4774	siderophore transport
Eco28_RS22175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Eco28_RS22180	COG1643	Atp-dependent helicase
Eco28_RS22185	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Eco28_RS22195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Eco28_RS22200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Eco28_RS22205	COG0617	tRNA 3'-terminal CCA addition
Eco28_RS22210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Eco28_RS22220	COG3121	Chaperone
Eco28_RS22225	COG3188	usher protein
Eco28_RS22230	COG3539	Fimbrial protein
Eco28_RS22265	COG5464	transposase or invertase
Eco28_RS22285	COG0726	polysaccharide deacetylase
Eco28_RS22290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS22295	COG0842	Transport permease protein
Eco28_RS22300	COG1131	(ABC) transporter
Eco28_RS22305	COG0288	reversible hydration of carbon dioxide
Eco28_RS22310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Eco28_RS22315	COG4993	Dehydrogenase
Eco28_RS22320	COG2132	Multicopper oxidase
Eco28_RS22345	COG1049	propionate catabolic process, 2-methylcitrate cycle
Eco28_RS22355	COG3064	Membrane
Eco28_RS22360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Eco28_RS22365	COG0508	dehydrogenase complex catalyzes the overall conversion of
Eco28_RS22370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Eco28_RS22380	COG2186	Transcriptional regulator
Eco28_RS22390	COG2211	Major facilitator Superfamily
Eco28_RS22395	COG3940	Belongs to the glycosyl hydrolase 43 family
Eco28_RS22400	COG3725	Membrane protein required for beta-lactamase induction
Eco28_RS22405	COG3023	N-Acetylmuramoyl-L-alanine amidase
Eco28_RS22410	COG0157	Belongs to the NadC ModD family
Eco28_RS22420	COG4969	Belongs to the N-Me-Phe pilin family
Eco28_RS22425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Eco28_RS22430	COG1459	type II secretion system
Eco28_RS22440	COG0237	dephospho-CoA kinase activity
Eco28_RS22455	COG0494	nUDIX hydrolase
Eco28_RS22475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Eco28_RS22480	COG0849	cell division
Eco28_RS22485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Eco28_RS22490	COG1181	Belongs to the D-alanine--D-alanine ligase family
Eco28_RS22505	COG0772	Belongs to the SEDS family
Eco28_RS22510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Eco28_RS22520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Eco28_RS22525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Eco28_RS22530	COG0768	penicillin binding
Eco28_RS22535	COG3116	cell division
Eco28_RS22555	COG1609	Transcriptional regulator
Eco28_RS22565	COG0440	acetolactate synthase activity
Eco28_RS22570	COG0028	Belongs to the TPP enzyme family
Eco28_RS22575	COG0583	DNA-binding transcription factor activity
Eco28_RS22620	COG4143	(ABC) transporter
Eco28_RS22625	COG1178	ABC-type Fe3 transport system permease component
Eco28_RS22635	COG0586	Pfam SNARE associated Golgi protein
Eco28_RS22640	COG4977	sequence-specific DNA binding
Eco28_RS22660	COG0235	Class ii aldolase
Eco28_RS22665	COG0417	DNA replication proofreading
Eco28_RS22675	COG0564	pseudouridine synthase activity
Eco28_RS22680	COG1357	PFAM Pentapeptide repeats (8 copies)
Eco28_RS22685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Eco28_RS22690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Eco28_RS22695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Eco28_RS22730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Eco28_RS22745	COG2271	Major facilitator Superfamily
Eco28_RS22750	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
Eco28_RS22755	COG0644	oxidoreductase
Eco28_RS22810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Eco28_RS22815	COG0505	Belongs to the CarA family
Eco28_RS22835	COG1047	Peptidyl-prolyl cis-trans
Eco28_RS22850	COG0196	riboflavin kinase activity
Eco28_RS22870	COG3039	Transposase
Eco28_RS22885	COG3121	Chaperone
Eco28_RS22890	COG3188	usher protein
Eco28_RS22900	COG0583	DNA-binding transcription factor activity
Eco28_RS22930	COG4735	regulation of single-species biofilm formation
Eco28_RS22935	COG1584	GPR1 FUN34 yaaH family protein
Eco28_RS22940	COG0521	Mo-molybdopterin cofactor biosynthetic process
Eco28_RS22945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Eco28_RS22950	COG1115	amino acid carrier protein
Eco28_RS22965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Eco28_RS22975	COG0460	homoserine dehydrogenase
Eco28_RS22975	COG0527	aspartate kinase activity
Eco28_RS22985	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Eco28_RS22995	COG0745	RESPONSE REGULATOR receiver
Eco28_RS23000	COG4452	Inner membrane protein CreD
Eco28_RS23005	COG2205	protein histidine kinase activity
Eco28_RS23010	COG0745	RESPONSE REGULATOR receiver
Eco28_RS23015	COG3045	CreA protein
Eco28_RS23020	COG2207	Transcriptional regulator
Eco28_RS23020	COG3708	Transcriptional regulator
Eco28_RS23040	COG0741	lytic transglycosylase activity
Eco28_RS23050	COG0488	(ABC) transporter
Eco28_RS23055	COG3172	ATPase kinase involved in NAD metabolism
Eco28_RS23055	COG1056	cytidyltransferase-related domain
Eco28_RS23060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Eco28_RS23065	COG0560	Phosphoserine phosphatase
Eco28_RS23070	COG3726	membrane protein affecting hemolysin expression
Eco28_RS23105	COG1328	CTP reductase activity
Eco28_RS23110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Eco28_RS23115	COG0084	hydrolase, TatD family'
Eco28_RS23120	COG4667	esterase of the alpha-beta hydrolase superfamily
Eco28_RS23130	COG2823	Periplasmic or secreted lipoprotein
Eco28_RS23140	COG1011	Hydrolase
Eco28_RS23145	COG0456	acetyltransferase
Eco28_RS23150	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
Eco28_RS23180	COG4114	ferric iron reductase
Eco28_RS23185	COG2197	response regulator
Eco28_RS23190	COG2197	response regulator
Eco28_RS23195	COG2966	Psort location CytoplasmicMembrane, score
Eco28_RS23210	COG1484	DNA-dependent DNA replication
Eco28_RS23225	COG1063	alcohol dehydrogenase
Eco28_RS23230	COG1802	Transcriptional regulator
Eco28_RS23235	COG2271	Major facilitator Superfamily
Eco28_RS23240	COG0840	transmembrane signaling receptor activity
Eco28_RS23255	COG1966	Carbon starvation protein
Eco28_RS23260	COG2879	small protein
Eco28_RS23265	COG0523	cobalamin synthesis protein
Eco28_RS23270	COG3039	Transposase
Eco28_RS23295	COG0732	type I restriction modification DNA specificity domain
Eco28_RS23310	COG5457	Domain of unknown function (DUF1127)
Eco28_RS23315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Eco28_RS23325	COG2814	Major facilitator Superfamily
Eco28_RS23330	COG2733	membrane
Eco28_RS23335	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Eco28_RS23340	COG1924	4 iron, 4 sulfur cluster binding
Eco28_RS23360	COG3204	pilus organization
Eco28_RS23365	COG0477	Major facilitator Superfamily
Eco28_RS23370	COG1470	cell adhesion involved in biofilm formation
Eco28_RS23370	COG1388	LysM domain
Eco28_RS23385	COG3366	ferrous iron transmembrane transporter activity
Eco28_RS23390	COG0700	Nucleoside recognition
Eco28_RS23395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Eco28_RS23400	COG0583	DNA-binding transcription factor activity
Eco28_RS23420	COG2186	Transcriptional regulator
Eco28_RS23430	COG0246	Mannitol dehydrogenase
Eco28_RS23445	COG2610	gluconate transmembrane transporter activity
Eco28_RS23450	COG3539	Fimbrial protein
Eco28_RS23455	COG3539	Fimbrial protein
Eco28_RS23460	COG3539	Fimbrial protein
Eco28_RS23465	COG3188	usher protein
Eco28_RS23470	COG3121	Chaperone
Eco28_RS23485	COG1205	dead DEAH box helicase
Eco28_RS23485	COG1111	helicase
Eco28_RS23515	COG3039	Transposase
Eco28_RS23535	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Eco28_RS23565	COG1064	alcohol dehydrogenase
Eco28_RS23570	COG3265	gluconokinase activity
Eco28_RS23580	COG1063	alcohol dehydrogenase
Eco28_RS23585	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS23590	COG2610	gluconate transmembrane transporter activity
Eco28_RS23595	COG1609	Transcriptional regulator
Eco28_RS23600	COG0433	COG0433 Predicted ATPase
Eco28_RS23605	COG0795	lipopolysaccharide-transporting ATPase activity
Eco28_RS23610	COG0795	lipopolysaccharide-transporting ATPase activity
Eco28_RS23620	COG2927	DNA polymerase III (CHI subunit)
Eco28_RS23630	COG4269	membrane
Eco28_RS23635	COG0456	acetyltransferase
Eco28_RS23640	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
Eco28_RS23655	COG2731	YhcH YjgK YiaL family protein
Eco28_RS23660	COG1309	transcriptional regulator
Eco28_RS23665	COG1028	Short-chain dehydrogenase reductase Sdr
Eco28_RS23670	COG0251	oxidation-reduction process
Eco28_RS23695	COG0251	oxidation-reduction process
Eco28_RS23700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Eco28_RS23705	COG1609	Transcriptional regulator
Eco28_RS23710	COG1263	PTS System
Eco28_RS23710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Eco28_RS23715	COG0366	Alpha amylase catalytic
Eco28_RS23720	COG1328	CTP reductase activity
Eco28_RS23725	COG0602	queuosine metabolic process
Eco28_RS23730	COG3783	Cytochrome b(562)
Eco28_RS23735	COG0312	modulator of DNA gyrase
Eco28_RS23745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Eco28_RS23755	COG1172	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS23760	COG1172	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS23765	COG1129	ABC transporter
Eco28_RS23770	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS23775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Eco28_RS23780	COG2337	Toxic component of a toxin-antitoxin (TA) module
Eco28_RS23785	COG2336	PFAM SpoVT AbrB
Eco28_RS23790	COG4974	Belongs to the 'phage' integrase family
Eco28_RS23880	COG4695	Portal protein
Eco28_RS23975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS23985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS24045	COG2105	PFAM AIG2 family protein
Eco28_RS24050	COG2911	Protein conserved in bacteria
Eco28_RS24055	COG0729	surface antigen
Eco28_RS24070	COG1253	flavin adenine dinucleotide binding
Eco28_RS24080	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Eco28_RS24095	COG1218	3'(2'),5'-bisphosphate nucleotidase
Eco28_RS24100	COG0737	Belongs to the 5'-nucleotidase family
Eco28_RS24105	COG1733	regulation of RNA biosynthetic process
Eco28_RS24110	COG0702	epimerase
Eco28_RS24115	COG0697	spore germination
Eco28_RS24125	COG1113	amino acid transport
Eco28_RS24130	COG0545	Peptidyl-prolyl cis-trans isomerase
Eco28_RS24140	COG3061	Opacity-associated protein A
Eco28_RS24145	COG1309	transcriptional regulator
Eco28_RS24150	COG0675	Transposase, IS605 OrfB family
Eco28_RS24175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Eco28_RS24210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS24215	COG3414	Phosphotransferase system galactitol-specific IIB component
Eco28_RS24220	COG3037	sugar-specific permease SgaT UlaA
Eco28_RS24235	COG1073	alpha beta
Eco28_RS24240	COG3650	response to hydrogen peroxide
Eco28_RS24250	COG1960	acyl-CoA dehydrogenase activity
Eco28_RS24255	COG0754	glutathionylspermidine amidase activity
Eco28_RS24260	COG5463	Belongs to the UPF0441 family
Eco28_RS24265	COG3766	membrane
Eco28_RS24275	COG1842	Phage shock protein A
Eco28_RS24280	COG3789	protein conserved in bacteria
Eco28_RS24290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Eco28_RS24295	COG0557	exoribonuclease II activity
Eco28_RS24310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Eco28_RS24315	COG0330	HflC and HflK could
Eco28_RS24320	COG0330	HflC and HflK could
Eco28_RS24325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Eco28_RS24345	COG0860	N-Acetylmuramoyl-L-alanine amidase
Eco28_RS24350	COG0802	atpase or kinase
Eco28_RS24355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Eco28_RS24355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Eco28_RS24395	COG1511	domain protein
Eco28_RS24395	COG3264	Mechanosensitive ion channel
Eco28_RS24400	COG0531	amino acid
Eco28_RS24410	COG1053	succinate dehydrogenase
Eco28_RS24415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Eco28_RS24430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Eco28_RS24435	COG3040	lipid binding
Eco28_RS24440	COG2076	Multidrug Resistance protein
Eco28_RS24445	COG5510	response to toxic substance
Eco28_RS24450	COG5510	response to toxic substance
Eco28_RS24460	COG1509	lysine 2,3-aminomutase activity
Eco28_RS24485	COG0531	amino acid
Eco28_RS24490	COG3030	protein affecting phage T7 exclusion by the F plasmid
Eco28_RS24495	COG1027	Aspartate ammonia-lyase
Eco28_RS24500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Eco28_RS24510	COG4232	protein-disulfide reductase activity
Eco28_RS24515	COG1309	transcriptional regulator
Eco28_RS24525	COG0582	viral genome integration into host DNA
Eco28_RS24580	COG2963	transposase activity
Eco28_RS24590	COG3039	Transposase
Eco28_RS24655	COG4983	Phage plasmid primase, P4 family domain protein
Eco28_RS24665	COG3468	outer membrane autotransporter barrel domain protein
Eco28_RS24685	COG2003	Belongs to the UPF0758 family
Eco28_RS24725	COG3609	addiction module antidote protein, CC2985 family
Eco28_RS24735	COG0582	viral genome integration into host DNA
Eco28_RS24745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Eco28_RS24745	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Eco28_RS24750	COG2194	sulfuric ester hydrolase activity
Eco28_RS24800	COG3436	PFAM IS66 Orf2 family protein
Eco28_RS24805	COG4372	Transposase
Eco28_RS24850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS24870	COG0583	DNA-binding transcription factor activity
Eco28_RS24875	COG0786	glutamate:sodium symporter activity
Eco28_RS24890	COG0640	Transcriptional regulator
Eco28_RS24950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Eco28_RS24970	COG2169	Transcriptional regulator
Eco28_RS24975	COG1486	melibiose metabolic process
Eco28_RS24980	COG2211	Major facilitator Superfamily
Eco28_RS24985	COG3647	Membrane
Eco28_RS24990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS24990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Eco28_RS24995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Eco28_RS25010	COG4565	transcriptional regulatory protein
Eco28_RS25015	COG3290	protein histidine kinase activity
Eco28_RS25020	COG3592	Divergent 4Fe-4S mono-cluster
Eco28_RS25025	COG2388	GCN5-related N-acetyl-transferase
Eco28_RS25045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Eco28_RS25050	COG3104	oligopeptide transport
Eco28_RS25055	COG1982	Orn Lys Arg decarboxylase major
Eco28_RS25060	COG0531	amino acid
Eco28_RS25070	COG3710	Transcriptional regulator
Eco28_RS25115	COG2003	Belongs to the UPF0758 family
Eco28_RS25140	COG3596	GTP binding
Eco28_RS25175	COG4771	TonB-dependent receptor
Eco28_RS25265	COG2169	Transcriptional regulator
Eco28_RS25270	COG1982	Orn Lys Arg decarboxylase major
Eco28_RS25275	COG2207	Transcriptional regulator
Eco28_RS25285	COG0531	amino acid
Eco28_RS25290	COG2194	sulfuric ester hydrolase activity
Eco28_RS25295	COG0745	RESPONSE REGULATOR receiver
Eco28_RS25300	COG0642	Histidine kinase
Eco28_RS25310	COG0477	Major facilitator Superfamily
Eco28_RS25320	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Eco28_RS25330	COG2824	Alkylphosphonate utilization operon protein PhnA
Eco28_RS25335	COG2764	glyoxalase bleomycin resistance protein dioxygenase
Eco28_RS25345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Eco28_RS25350	COG3639	organic phosphonate transmembrane transporter activity
Eco28_RS25355	COG2188	Transcriptional regulator
Eco28_RS25360	COG3624	Phosphonate C-P lyase system protein PhnG
Eco28_RS25365	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Eco28_RS25370	COG3626	phosphonate metabolism
Eco28_RS25375	COG3627	carbon phosphorus lyase activity
Eco28_RS25380	COG4107	phosphonate C-P lyase system protein PhnK
Eco28_RS25385	COG4778	phosphonate C-P lyase system protein PhnL
Eco28_RS25390	COG3454	Phosphonate metabolism
Eco28_RS25395	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Eco28_RS25400	COG0456	acetyltransferase
Eco28_RS25405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Eco28_RS25415	COG0698	ribose 5-phosphate isomerase
Eco28_RS25420	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Eco28_RS25430	COG1566	PFAM secretion protein HlyD family protein
Eco28_RS25435	COG1289	transmembrane transporter activity
Eco28_RS25450	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Eco28_RS25455	COG1301	dicarboxylic acid transport
Eco28_RS25465	COG4235	cytochrome complex assembly
Eco28_RS25470	COG3088	subunit of a heme lyase
Eco28_RS25475	COG1138	Cytochrome C-type biogenesis protein
Eco28_RS25480	COG3301	Polysulphide reductase, NrfD
Eco28_RS25485	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS25490	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Eco28_RS25505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Eco28_RS25510	COG3162	membrane
Eco28_RS25520	COG1357	PFAM Pentapeptide repeats (8 copies)
Eco28_RS25525	COG0025	NhaP-type Na H and K H
Eco28_RS25530	COG2252	PERMEase
Eco28_RS25550	COG0789	Transcriptional regulator
Eco28_RS25555	COG2207	Transcriptional regulator
Eco28_RS25560	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Eco28_RS25575	COG0629	single-stranded DNA binding
Eco28_RS25580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Eco28_RS25585	COG2315	Protein conserved in bacteria
Eco28_RS25590	COG0432	Pfam Uncharacterised protein family UPF0047
Eco28_RS25595	COG3700	Belongs to the class B bacterial acid phosphatase family
Eco28_RS25605	COG1448	Aminotransferase
Eco28_RS25610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Eco28_RS25615	COG0305	Participates in initiation and elongation during chromosome replication
Eco28_RS25620	COG0604	alcohol dehydrogenase
Eco28_RS25630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Eco28_RS25660	COG0735	belongs to the Fur family
Eco28_RS25665	COG3237	CsbD-like
Eco28_RS25670	COG0534	Mate efflux family protein
Eco28_RS25680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Eco28_RS25705	COG1357	PFAM Pentapeptide repeats (8 copies)
Eco28_RS25720	COG3842	ATPase activity
Eco28_RS25730	COG2182	Extracellular solute-binding protein
Eco28_RS25735	COG1175	transmembrane transport
Eco28_RS25740	COG3833	ABC-type maltose transport systems, permease component
Eco28_RS25750	COG0477	Major facilitator Superfamily
Eco28_RS25750	COG2814	Major facilitator Superfamily
Eco28_RS25765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Eco28_RS25805	COG0527	aspartate kinase activity
Eco28_RS25810	COG0542	response to heat
Eco28_RS25815	COG3541	Predicted nucleotidyltransferase
Eco28_RS25835	COG0561	phosphatase activity
Eco28_RS25840	COG1349	DNA-binding transcription factor activity
Eco28_RS25850	COG1187	pseudouridine synthase activity
Eco28_RS25900	COG1283	sodium-dependent phosphate transmembrane transporter activity
Eco28_RS25905	COG0646	methionine synthase
Eco28_RS25905	COG1410	methionine synthase
Eco28_RS25910	COG1414	Transcriptional regulator
Eco28_RS25925	COG2224	Isocitrate lyase
Eco28_RS25930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Eco28_RS25940	COG0456	acetyltransferase
Eco28_RS25980	COG0151	Belongs to the GarS family
Eco28_RS25985	COG2204	response regulator
Eco28_RS25990	COG4191	Histidine kinase
Eco28_RS26000	COG3678	ATP-independent chaperone mediated protein folding
Eco28_RS26015	COG3068	Protein conserved in bacteria
Eco28_RS26050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Eco28_RS26055	COG2104	thiamine diphosphate biosynthetic process
Eco28_RS26065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Eco28_RS26110	COG0250	Participates in transcription elongation, termination and antitermination
Eco28_RS26115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Eco28_RS26160	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Eco28_RS26160	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Eco28_RS26195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Eco28_RS26200	COG4206	TonB-dependent receptor
Eco28_RS26205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Eco28_RS26220	COG0477	Major facilitator Superfamily
Eco28_RS26225	COG1473	amidohydrolase
Eco28_RS26235	COG0583	DNA-binding transcription factor activity
Eco28_RS26250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Eco28_RS26265	COG2194	sulfuric ester hydrolase activity
Eco28_RS26270	COG2207	Transcriptional regulator
Eco28_RS26275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS26280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Eco28_RS26285	COG1882	Formate acetyltransferase
Eco28_RS26290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS26295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Eco28_RS26300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Eco28_RS26300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS26300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS26305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Eco28_RS26310	COG0371	Dehydrogenase
Eco28_RS26315	COG3738	Protein conserved in bacteria
Eco28_RS26320	COG0697	spore germination
Eco28_RS26330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Eco28_RS26340	COG0527	aspartate kinase activity
Eco28_RS26340	COG0460	homoserine dehydrogenase
Eco28_RS26345	COG0626	cystathionine gamma-synthase activity
Eco28_RS26360	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
Eco28_RS26370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Eco28_RS26375	COG1609	Transcriptional regulator
Eco28_RS26380	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Eco28_RS26395	COG1575	Belongs to the MenA family. Type 1 subfamily
Eco28_RS26420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Eco28_RS26430	COG1494	fructose-1,6-bisphosphatase
Eco28_RS26440	COG0589	response to stress
Eco28_RS26445	COG3691	Protein conserved in bacteria
Eco28_RS26450	COG3152	Membrane
Eco28_RS26475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Eco28_RS26530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Eco28_RS26545	COG2771	luxR family
Eco28_RS26610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Eco28_RS26705	COG4695	Portal protein
Eco28_RS26770	COG4974	Belongs to the 'phage' integrase family
Eco28_RS26775	COG3678	ATP-independent chaperone mediated protein folding
Eco28_RS26780	COG0745	RESPONSE REGULATOR receiver
Eco28_RS26785	COG2205	protein histidine kinase activity
Eco28_RS26790	COG2258	MOSC domain
Eco28_RS26805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Eco28_RS26815	COG1917	Cupin 2, conserved barrel domain protein
Eco28_RS26815	COG4977	sequence-specific DNA binding
Eco28_RS26850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS26860	COG1363	Peptidase, m42
Eco28_RS26865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Eco28_RS26865	COG3711	transcriptional antiterminator
Eco28_RS26885	COG3383	formate dehydrogenase (NAD+) activity
Eco28_RS26885	COG0243	molybdopterin cofactor binding
Eco28_RS26890	COG0243	molybdopterin cofactor binding
Eco28_RS26890	COG3383	formate dehydrogenase (NAD+) activity
Eco28_RS26895	COG0437	4 iron, 4 sulfur cluster binding
Eco28_RS26900	COG2864	formate dehydrogenase
Eco28_RS26915	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Eco28_RS26935	COG0456	acetyltransferase
Eco28_RS26950	COG1011	Hydrolase
Eco28_RS26955	COG1349	DNA-binding transcription factor activity
Eco28_RS26960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS26965	COG2084	Dehydrogenase
Eco28_RS26970	COG3684	Belongs to the aldolase LacD family
Eco28_RS26975	COG2942	2-epimerase
Eco28_RS26980	COG2017	converts alpha-aldose to the beta-anomer
Eco28_RS26990	COG1501	Belongs to the glycosyl hydrolase 31 family
Eco28_RS26995	COG2211	Major facilitator Superfamily
Eco28_RS27000	COG2211	Major facilitator Superfamily
Eco28_RS27005	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Eco28_RS27010	COG2271	Major facilitator Superfamily
Eco28_RS27015	COG1082	Xylose isomerase domain protein TIM barrel
Eco28_RS27020	COG2188	Transcriptional regulator
Eco28_RS27025	COG1217	gtp-binding protein TYPA
Eco28_RS27035	COG0174	glutamine synthetase
Eco28_RS27040	COG3852	Histidine kinase
Eco28_RS27045	COG2204	response regulator
Eco28_RS27055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Eco28_RS27060	COG3078	GTPase activator activity
Eco28_RS27070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Eco28_RS27070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Eco28_RS27080	COG0204	Acyl-transferase
Eco28_RS27085	COG5339	Protein conserved in bacteria
Eco28_RS27090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Eco28_RS27095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Eco28_RS27100	COG3084	Protein conserved in bacteria
Eco28_RS27105	COG0746	molybdenum cofactor guanylyltransferase activity
Eco28_RS27110	COG1763	Mo-molybdopterin cofactor biosynthetic process
Eco28_RS27140	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
Eco28_RS27145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Eco28_RS27150	COG1739	Uncharacterized protein family UPF0029
Eco28_RS27165	COG0183	Belongs to the thiolase family
Eco28_RS27170	COG0543	2 iron, 2 sulfur cluster binding
Eco28_RS27180	COG0250	Participates in transcription elongation, termination and antitermination
Eco28_RS27190	COG0805	protein transport
Eco28_RS27195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Eco28_RS27200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Eco28_RS27210	COG3165	ubiquinone biosynthetic process from chorismate
Eco28_RS27220	COG1322	Protein conserved in bacteria
Eco28_RS27225	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Eco28_RS27230	COG0412	Dienelactone hydrolase
Eco28_RS27240	COG0583	DNA-binding transcription factor activity
Eco28_RS27245	COG0697	spore germination
Eco28_RS27250	COG0561	phosphatase activity
Eco28_RS27255	COG2267	carboxylic ester hydrolase activity
Eco28_RS27260	COG1280	lysine exporter protein (LysE YggA)
Eco28_RS27265	COG1280	lysine exporter protein (LysE YggA)
Eco28_RS27270	COG0514	ATP-dependent DNA helicase (RecQ)
Eco28_RS27275	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Eco28_RS27280	COG2050	protein possibly involved in aromatic compounds catabolism
Eco28_RS27285	COG2962	Rard protein
Eco28_RS27315	COG0598	Magnesium transport protein CorA
Eco28_RS27320	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
Eco28_RS27325	COG0210	DNA helicase
Eco28_RS27330	COG1011	Hydrolase
Eco28_RS27340	COG3159	Protein conserved in bacteria
Eco28_RS27350	COG5567	small periplasmic lipoprotein
Eco28_RS27360	COG3072	Adenylate cyclase
Eco28_RS27375	COG1587	Uroporphyrinogen-III synthase
Eco28_RS27380	COG2959	enzyme of heme biosynthesis
Eco28_RS27385	COG3071	HemY protein
Eco28_RS27390	COG3119	arylsulfatase activity
Eco28_RS27395	COG0641	radical SAM
Eco28_RS27420	COG1113	amino acid transport
Eco28_RS27440	COG2244	polysaccharide biosynthetic process
Eco28_RS27445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Eco28_RS27450	COG0456	acetyltransferase
Eco28_RS27460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Eco28_RS27465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Eco28_RS27470	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Eco28_RS27475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Eco28_RS27485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Eco28_RS27495	COG3118	belongs to the thioredoxin family
Eco28_RS27515	COG0210	DNA helicase
Eco28_RS27520	COG3692	DNA binding
Eco28_RS27525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Eco28_RS27535	COG0583	DNA-binding transcription factor activity
Eco28_RS27540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Eco28_RS27550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Eco28_RS27555	COG3978	acetolactate synthase activity
Eco28_RS27570	COG0606	chelatase, subunit chli
Eco28_RS27575	COG3085	chromosome segregation
Eco28_RS27615	COG2186	Transcriptional regulator
Eco28_RS27620	COG0477	Major facilitator Superfamily
Eco28_RS27625	COG1609	Transcriptional regulator
Eco28_RS27630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Eco28_RS27635	COG1879	ABC-type sugar transport system periplasmic component
Eco28_RS27640	COG1172	Belongs to the binding-protein-dependent transport system permease family
Eco28_RS27645	COG1129	ABC transporter
Eco28_RS27675	COG1522	sequence-specific DNA binding
Eco28_RS27680	COG0716	FMN binding
Eco28_RS27695	COG3312	ion transport
Eco28_RS27745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Eco28_RS27755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Eco28_RS27760	COG0573	inorganic phosphate transmembrane transporter activity
Eco28_RS27765	COG0581	inorganic phosphate transmembrane transporter activity
Eco28_RS27770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Eco28_RS27775	COG0704	Plays a role in the regulation of phosphate uptake
Eco28_RS27810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Eco28_RS27815	COG2252	PERMEase
Eco28_RS27820	COG0431	NADPH-dependent FMN reductase
Eco28_RS27825	COG2091	lysine biosynthetic process via aminoadipic acid
Eco28_RS27840	COG0814	amino acid