locus-tag	class	description
H8529_RS00010	COG0592	DNA-directed DNA polymerase activity
H8529_RS00020	COG0187	DNA topoisomerase II activity
H8529_RS00025	COG3753	Protein conserved in bacteria
H8529_RS00030	COG0561	phosphatase activity
H8529_RS00040	COG2186	Transcriptional regulator
H8529_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
H8529_RS00050	COG0800	Aldolase
H8529_RS00060	COG2271	Major facilitator Superfamily
H8529_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
H8529_RS00075	COG5645	(Lipo)protein
H8529_RS00095	COG2188	Transcriptional regulator
H8529_RS00110	COG2207	Transcriptional regulator
H8529_RS00115	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8529_RS00120	COG3119	arylsulfatase activity
H8529_RS00130	COG2149	membrane
H8529_RS00140	COG0641	radical SAM
H8529_RS00145	COG2814	Major facilitator Superfamily
H8529_RS00160	COG0028	Belongs to the TPP enzyme family
H8529_RS00165	COG0440	acetolactate synthase activity
H8529_RS00170	COG2197	response regulator
H8529_RS00175	COG3851	Histidine kinase
H8529_RS00180	COG2271	Major facilitator Superfamily
H8529_RS00185	COG2271	Major facilitator Superfamily
H8529_RS00195	COG2252	PERMEase
H8529_RS00215	COG1464	Belongs to the NlpA lipoprotein family
H8529_RS00220	COG0697	spore germination
H8529_RS00285	COG0582	viral genome integration into host DNA
H8529_RS00295	COG2211	Major facilitator Superfamily
H8529_RS00300	COG1501	Belongs to the glycosyl hydrolase 31 family
H8529_RS00305	COG2982	Protein involved in outer membrane biogenesis
H8529_RS00310	COG2233	PERMEase
H8529_RS00315	COG0786	glutamate:sodium symporter activity
H8529_RS00325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8529_RS00330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8529_RS00335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8529_RS00345	COG0194	GDP metabolic process
H8529_RS00355	COG2860	membrane
H8529_RS00360	COG3645	SOS response
H8529_RS00365	COG1561	YicC-like family, N-terminal region
H8529_RS00390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8529_RS00420	COG1519	Transferase
H8529_RS00425	COG0859	PFAM glycosyl transferase family 9
H8529_RS00430	COG0438	transferase activity, transferring glycosyl groups
H8529_RS00435	COG0515	serine threonine protein kinase
H8529_RS00450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H8529_RS00455	COG1442	glycosyl transferase family 8
H8529_RS00470	COG0859	PFAM glycosyl transferase family 9
H8529_RS00475	COG0859	PFAM glycosyl transferase family 9
H8529_RS00485	COG0156	8-amino-7-oxononanoate synthase activity
H8529_RS00495	COG1216	Glycosyl transferase, family 2
H8529_RS00500	COG2861	carbohydrate metabolic process
H8529_RS00505	COG4942	peptidase
H8529_RS00515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8529_RS00520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8529_RS00535	COG1045	serine acetyltransferase
H8529_RS00540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8529_RS00550	COG2186	Transcriptional regulator
H8529_RS00555	COG1620	l-lactate permease
H8529_RS00560	COG5295	Hep Hag repeat protein
H8529_RS00580	COG3722	fumarate hydratase activity
H8529_RS00590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS00590	COG2213	PTS system mannitol-specific
H8529_RS00600	COG1566	PFAM secretion protein HlyD family protein
H8529_RS00610	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H8529_RS00630	COG1413	lyase activity
H8529_RS00640	COG3209	COG3209 Rhs family protein
H8529_RS00645	COG0625	glutathione transferase activity
H8529_RS00655	COG3276	selenocysteine insertion sequence binding
H8529_RS00660	COG1454	alcohol dehydrogenase
H8529_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS00680	COG1566	PFAM secretion protein HlyD family protein
H8529_RS00685	COG0583	DNA-binding transcription factor activity
H8529_RS00690	COG3713	MltA-interacting MipA family protein
H8529_RS00695	COG0235	Class ii aldolase
H8529_RS00700	COG3623	hexulose-6-phosphate isomerase
H8529_RS00705	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H8529_RS00710	COG1070	Carbohydrate kinase
H8529_RS00715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8529_RS00720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H8529_RS00725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H8529_RS00730	COG2731	YhcH YjgK YiaL family protein
H8529_RS00740	COG1414	Transcriptional regulator
H8529_RS00745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS00750	COG3977	Valine--pyruvate aminotransferase
H8529_RS00755	COG0366	Alpha amylase catalytic
H8529_RS00760	COG2992	FlgJ-related protein
H8529_RS00765	COG1609	Transcriptional regulator
H8529_RS00765	COG2207	Transcriptional regulator
H8529_RS00770	COG4214	carbohydrate transport
H8529_RS00775	COG1129	ABC transporter
H8529_RS00780	COG4213	ABC transporter substrate-binding protein
H8529_RS00790	COG1070	Carbohydrate kinase
H8529_RS00795	COG4682	membrane
H8529_RS00800	COG4682	membrane
H8529_RS00805	COG3274	enterobacterial common antigen metabolic process
H8529_RS00830	COG1278	Cold shock
H8529_RS00835	COG2944	sequence-specific DNA binding
H8529_RS00850	COG2885	chlorophyll binding
H8529_RS00855	COG0243	molybdopterin cofactor binding
H8529_RS00860	COG0456	acetyltransferase
H8529_RS00865	COG2818	Glycosylase
H8529_RS00870	COG5571	outer membrane autotransporter
H8529_RS00875	COG2223	nitrite transmembrane transporter activity
H8529_RS00905	COG2194	sulfuric ester hydrolase activity
H8529_RS00915	COG0747	negative chemotaxis
H8529_RS00920	COG0601	transmembrane transport
H8529_RS00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8529_RS00930	COG0444	Belongs to the ABC transporter superfamily
H8529_RS00935	COG4608	Belongs to the ABC transporter superfamily
H8529_RS00940	COG0814	amino acid
H8529_RS00960	COG2194	sulfuric ester hydrolase activity
H8529_RS00985	COG1215	transferase activity, transferring glycosyl groups
H8529_RS00990	COG1215	transferase activity, transferring glycosyl groups
H8529_RS00995	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8529_RS01000	COG3118	belongs to the thioredoxin family
H8529_RS01000	COG0457	Tetratricopeptide repeat
H8529_RS01005	COG2199	diguanylate cyclase activity
H8529_RS01005	COG2200	EAL domain
H8529_RS01015	COG0612	Peptidase, M16
H8529_RS01025	COG2200	EAL domain
H8529_RS01030	COG2982	Protein involved in outer membrane biogenesis
H8529_RS01035	COG0477	Major facilitator Superfamily
H8529_RS01040	COG1295	ribonuclease BN
H8529_RS01045	COG0583	DNA-binding transcription factor activity
H8529_RS01050	COG2197	response regulator
H8529_RS01060	COG1858	cytochrome C peroxidase
H8529_RS01065	COG0076	glutamate decarboxylase activity
H8529_RS01075	COG2207	Transcriptional regulator
H8529_RS01080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8529_RS01085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS01095	COG2771	luxR family
H8529_RS01100	COG3247	response to pH
H8529_RS01115	COG1285	pathogenesis
H8529_RS01120	COG2197	response regulator
H8529_RS01125	COG3065	identical protein binding
H8529_RS01145	COG1393	Belongs to the ArsC family
H8529_RS01150	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8529_RS01155	COG0640	Transcriptional regulator
H8529_RS01165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8529_RS01170	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H8529_RS01175	COG0339	signal peptide processing
H8529_RS01185	COG3104	oligopeptide transport
H8529_RS01190	COG0589	response to stress
H8529_RS01200	COG0306	phosphate transporter
H8529_RS01205	COG2081	HI0933 family
H8529_RS01225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS01230	COG0842	Transport permease protein
H8529_RS01230	COG1129	ABC transporter
H8529_RS01235	COG0842	Transport permease protein
H8529_RS01260	COG0444	Belongs to the ABC transporter superfamily
H8529_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8529_RS01270	COG0601	transmembrane transport
H8529_RS01275	COG0747	negative chemotaxis
H8529_RS01280	COG2091	lysine biosynthetic process via aminoadipic acid
H8529_RS01285	COG0628	permease
H8529_RS01300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8529_RS01315	COG3714	YhhN family
H8529_RS01325	COG3776	membrane
H8529_RS01330	COG0742	ribosomal rna small subunit methyltransferase
H8529_RS01335	COG0552	protein localization to endoplasmic reticulum
H8529_RS01340	COG2884	Cell division ATP-binding protein ftsE
H8529_RS01345	COG2177	Part of the ABC transporter FtsEX involved in
H8529_RS01350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8529_RS01355	COG0683	leucine binding
H8529_RS01360	COG0456	acetyltransferase
H8529_RS01365	COG0683	leucine binding
H8529_RS01370	COG0559	Belongs to the binding-protein-dependent transport system permease family
H8529_RS01375	COG4177	L-phenylalanine transmembrane transporter activity
H8529_RS01380	COG0411	ABC transporter
H8529_RS01385	COG0410	ABC transporter
H8529_RS01390	COG1653	transport
H8529_RS01395	COG1175	transmembrane transport
H8529_RS01405	COG3842	ATPase activity
H8529_RS01410	COG0584	glycerophosphoryl diester phosphodiesterase
H8529_RS01420	COG0405	Gamma-glutamyltransferase
H8529_RS01440	COG3157	Type VI secretion system effector, Hcp
H8529_RS01445	COG1247	-acetyltransferase
H8529_RS01450	COG0673	inositol 2-dehydrogenase activity
H8529_RS01455	COG1741	Belongs to the pirin family
H8529_RS01460	COG1609	Transcriptional regulator
H8529_RS01465	COG3265	gluconokinase activity
H8529_RS01470	COG2610	gluconate transmembrane transporter activity
H8529_RS01475	COG2095	MarC family integral membrane protein
H8529_RS01480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8529_RS01505	COG0058	SHG alpha-glucan phosphorylase activity
H8529_RS01510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8529_RS01530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8529_RS01545	COG1349	DNA-binding transcription factor activity
H8529_RS01550	COG4650	regulator
H8529_RS01555	COG1690	Belongs to the RtcB family
H8529_RS01570	COG0058	SHG alpha-glucan phosphorylase activity
H8529_RS01575	COG1640	4-alpha-glucanotransferase
H8529_RS01580	COG2610	gluconate transmembrane transporter activity
H8529_RS01600	COG5464	transposase or invertase
H8529_RS01610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H8529_RS01615	COG1918	ferrous iron import across plasma membrane
H8529_RS01620	COG2183	response to ionizing radiation
H8529_RS01625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8529_RS01655	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H8529_RS01665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H8529_RS01670	COG1011	Hydrolase
H8529_RS01680	COG0494	nUDIX hydrolase
H8529_RS01685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H8529_RS01690	COG4972	Pilus assembly protein
H8529_RS01695	COG3166	PFAM Fimbrial assembly family protein
H8529_RS01710	COG4796	Type ii and iii secretion system protein
H8529_RS01725	COG3266	domain, Protein
H8529_RS01730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H8529_RS01735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8529_RS01740	COG0546	phosphoglycolate phosphatase activity
H8529_RS01745	COG0180	Tryptophanyl-tRNA synthetase
H8529_RS01750	COG2188	Transcriptional regulator
H8529_RS01760	COG3457	Alanine racemase
H8529_RS01765	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H8529_RS01770	COG1735	metal-dependent hydrolase with the TIM-barrel fold
H8529_RS01785	COG0626	cystathionine gamma-synthase activity
H8529_RS01790	COG2188	Transcriptional regulator
H8529_RS01800	COG1082	Xylose isomerase domain protein TIM barrel
H8529_RS01805	COG2222	sugar isomerase
H8529_RS01810	COG0531	amino acid
H8529_RS01825	COG2116	formate transmembrane transporter activity
H8529_RS01830	COG2146	nitrite reductase [NAD(P)H] activity
H8529_RS01835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8529_RS01845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8529_RS01855	COG2184	nucleotidyltransferase activity
H8529_RS01860	COG0512	Glutamine amidotransferase of anthranilate synthase
H8529_RS01865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8529_RS01870	COG1289	transmembrane transporter activity
H8529_RS01875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8529_RS01880	COG1765	OsmC-like protein
H8529_RS01885	COG3954	Phosphoribulokinase
H8529_RS01895	COG0429	hydrolase of the alpha beta-hydrolase fold
H8529_RS01900	COG0488	(ABC) transporter
H8529_RS01915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H8529_RS01920	COG1047	Peptidyl-prolyl cis-trans
H8529_RS01930	COG0545	Peptidyl-prolyl cis-trans isomerase
H8529_RS01935	COG2964	Protein conserved in bacteria
H8529_RS02005	COG0089	rRNA binding
H8529_RS02095	COG0201	protein transport
H8529_RS02135	COG0789	Transcriptional regulator
H8529_RS02140	COG3036	rescue of stalled ribosome
H8529_RS02150	COG0569	domain protein
H8529_RS02170	COG0758	DNA mediated transformation
H8529_RS02180	COG0551	DNA topoisomerase type I activity
H8529_RS02200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8529_RS02240	COG1126	abc transporter atp-binding protein
H8529_RS02245	COG0765	amino acid transport
H8529_RS02250	COG4597	amino acid ABC transporter
H8529_RS02255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8529_RS02270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS02275	COG1309	transcriptional regulator
H8529_RS02285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8529_RS02295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8529_RS02305	COG4145	pantothenate transmembrane transporter activity
H8529_RS02310	COG3924	membrane
H8529_RS02315	COG0439	Biotin carboxylase
H8529_RS02320	COG0511	ligase activity, forming carbon-carbon bonds
H8529_RS02325	COG0604	alcohol dehydrogenase
H8529_RS02330	COG2199	diguanylate cyclase activity
H8529_RS02330	COG2200	EAL domain
H8529_RS02335	COG1077	Cell shape determining protein MreB Mrl
H8529_RS02340	COG1792	Involved in formation and maintenance of cell shape
H8529_RS02345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H8529_RS02350	COG0424	maF-like protein
H8529_RS02355	COG1530	ribonuclease E activity
H8529_RS02360	COG3164	Protein of unknown function
H8529_RS02365	COG0312	modulator of DNA gyrase
H8529_RS02370	COG0583	DNA-binding transcription factor activity
H8529_RS02390	COG2732	(Barnase) inhibitor
H8529_RS02410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8529_RS02415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8529_RS02420	COG3105	Protein conserved in bacteria
H8529_RS02425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H8529_RS02440	COG0625	glutathione transferase activity
H8529_RS02445	COG2969	positive regulation of protein catabolic process
H8529_RS02450	COG3069	C4-dicarboxylate transmembrane transporter activity
H8529_RS02480	COG2731	YhcH YjgK YiaL family protein
H8529_RS02490	COG4804	nuclease activity
H8529_RS02495	COG0493	'glutamate synthase
H8529_RS02500	COG0070	glutamate synthase
H8529_RS02500	COG0069	glutamate synthase activity
H8529_RS02500	COG0067	glutamate synthase
H8529_RS02505	COG1242	4 iron, 4 sulfur cluster binding
H8529_RS02510	COG5002	protein histidine kinase activity
H8529_RS02510	COG2198	Histidine kinase
H8529_RS02510	COG0784	Response regulator, receiver
H8529_RS02515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H8529_RS02525	COG0515	serine threonine protein kinase
H8529_RS02530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8529_RS02550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H8529_RS02555	COG1137	ATPase activity
H8529_RS02560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H8529_RS02565	COG3117	lipopolysaccharide transmembrane transporter activity
H8529_RS02570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H8529_RS02575	COG0517	IMP dehydrogenase activity
H8529_RS02575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H8529_RS02580	COG0530	calcium, potassium:sodium antiporter activity
H8529_RS02585	COG1127	ABC transporter
H8529_RS02590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H8529_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8529_RS02600	COG2854	intermembrane phospholipid transfer
H8529_RS02605	COG3113	response to antibiotic
H8529_RS02610	COG5007	Belongs to the BolA IbaG family
H8529_RS02620	COG3423	Transcriptional regulator
H8529_RS02625	COG0142	geranyltranstransferase activity
H8529_RS02640	COG0697	spore germination
H8529_RS02650	COG2027	D-alanyl-D-alanine carboxypeptidase
H8529_RS02655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8529_RS02660	COG1534	Rna-binding protein
H8529_RS02670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8529_RS02675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8529_RS02685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8529_RS02695	COG2194	sulfuric ester hydrolase activity
H8529_RS02715	COG0195	Participates in both transcription termination and antitermination
H8529_RS02755	COG0513	Belongs to the DEAD box helicase family
H8529_RS02760	COG0814	amino acid
H8529_RS02765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8529_RS02770	COG0826	peptidase U32
H8529_RS02775	COG0826	peptidase U32
H8529_RS02780	COG3154	lipid carrier protein
H8529_RS02785	COG3153	acetyltransferase
H8529_RS02800	COG0693	protein deglycase activity
H8529_RS02805	COG0702	epimerase
H8529_RS02810	COG0701	Predicted permease
H8529_RS02815	COG2823	Periplasmic or secreted lipoprotein
H8529_RS02835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8529_RS02840	COG3539	Fimbrial protein
H8529_RS02845	COG3188	usher protein
H8529_RS02850	COG3121	Chaperone
H8529_RS02855	COG3539	Fimbrial protein
H8529_RS02860	COG0363	glucosamine-6-phosphate deaminase activity
H8529_RS02865	COG3716	PTS system mannose fructose sorbose family IID component
H8529_RS02870	COG3715	PTS system
H8529_RS02875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS02885	COG2222	sugar isomerase
H8529_RS02890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8529_RS02895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS02900	COG3716	PTS system mannose fructose sorbose family IID component
H8529_RS02910	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS02920	COG1349	DNA-binding transcription factor activity
H8529_RS02930	COG2002	toxin-antitoxin pair type II binding
H8529_RS02935	COG2721	sulfolactate sulfo-lyase activity
H8529_RS02940	COG2271	Major facilitator Superfamily
H8529_RS02950	COG2084	Dehydrogenase
H8529_RS02955	COG1929	Belongs to the glycerate kinase type-1 family
H8529_RS02980	COG0583	DNA-binding transcription factor activity
H8529_RS02985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8529_RS02995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8529_RS03000	COG1882	Formate acetyltransferase
H8529_RS03005	COG0251	oxidation-reduction process
H8529_RS03010	COG1760	l-serine dehydratase
H8529_RS03015	COG0814	amino acid
H8529_RS03030	COG1741	Belongs to the pirin family
H8529_RS03035	COG0583	DNA-binding transcription factor activity
H8529_RS03040	COG3152	Membrane
H8529_RS03045	COG3152	Membrane
H8529_RS03050	COG0435	Glutathione S-transferase
H8529_RS03055	COG2259	Doxx family
H8529_RS03065	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
H8529_RS03070	COG4575	ribosome binding
H8529_RS03075	COG1422	Protein of unknown function (DUF1090)
H8529_RS03085	COG0586	Pfam SNARE associated Golgi protein
H8529_RS03090	COG2186	Transcriptional regulator
H8529_RS03115	COG2271	Major facilitator Superfamily
H8529_RS03125	COG2721	sulfolactate sulfo-lyase activity
H8529_RS03135	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H8529_RS03140	COG0861	Integral membrane protein TerC family
H8529_RS03145	COG0673	inositol 2-dehydrogenase activity
H8529_RS03150	COG2949	membrane
H8529_RS03155	COG1451	nucleotide metabolic process
H8529_RS03170	COG5499	transcription regulator containing HTH domain
H8529_RS03175	COG0446	pyridine nucleotide-disulphide oxidoreductase
H8529_RS03175	COG1902	pentaerythritol trinitrate reductase activity
H8529_RS03180	COG3408	Glycogen debranching enzyme
H8529_RS03180	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H8529_RS03190	COG0531	amino acid
H8529_RS03195	COG2731	YhcH YjgK YiaL family protein
H8529_RS03200	COG3250	beta-galactosidase activity
H8529_RS03205	COG1609	Transcriptional regulator
H8529_RS03210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8529_RS03220	COG0840	transmembrane signaling receptor activity
H8529_RS03225	COG1695	Transcriptional regulator
H8529_RS03230	COG2375	cellular response to nickel ion
H8529_RS03245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8529_RS03250	COG0358	DNA primase activity
H8529_RS03255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H8529_RS03270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H8529_RS03275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H8529_RS03280	COG0583	DNA-binding transcription factor activity
H8529_RS03290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8529_RS03305	COG4991	sh3 domain protein
H8529_RS03310	COG3025	triphosphatase activity
H8529_RS03335	COG2268	Band 7 protein
H8529_RS03340	COG1585	Membrane protein implicated in regulation of membrane protease activity
H8529_RS03350	COG3539	Fimbrial protein
H8529_RS03355	COG3121	Chaperone
H8529_RS03360	COG3188	usher protein
H8529_RS03365	COG3539	Fimbrial protein
H8529_RS03370	COG2960	long-chain fatty acid transporting porin activity
H8529_RS03390	COG3384	dioxygenase
H8529_RS03395	COG0754	glutathionylspermidine amidase activity
H8529_RS03405	COG1538	Outer membrane efflux protein
H8529_RS03410	COG0494	nUDIX hydrolase
H8529_RS03415	COG3151	Protein conserved in bacteria
H8529_RS03420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8529_RS03425	COG3150	esterase
H8529_RS03430	COG0187	DNA topoisomerase II activity
H8529_RS03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS03470	COG2211	Major facilitator Superfamily
H8529_RS03475	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H8529_RS03480	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8529_RS03490	COG0642	Histidine kinase
H8529_RS03495	COG0745	RESPONSE REGULATOR receiver
H8529_RS03500	COG3111	PFAM Bacterial OB fold (BOF) protein
H8529_RS03505	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H8529_RS03510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8529_RS03515	COG0204	Acyl-transferase
H8529_RS03520	COG2132	Multicopper oxidase
H8529_RS03525	COG1032	radical SAM domain protein
H8529_RS03530	COG4238	major outer membrane lipoprotein
H8529_RS03540	COG0656	L-ascorbic acid biosynthetic process
H8529_RS03545	COG1979	alcohol dehydrogenase
H8529_RS03550	COG2207	Transcriptional regulator
H8529_RS03555	COG0586	Pfam SNARE associated Golgi protein
H8529_RS03560	COG0626	cystathionine gamma-synthase activity
H8529_RS03565	COG0811	peptide transport
H8529_RS03570	COG0848	biopolymer transport protein
H8529_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS03585	COG0667	Aldo Keto reductase
H8529_RS03600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H8529_RS03605	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS03610	COG5557	Pfam Polysulphide reductase, NrfD
H8529_RS03615	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H8529_RS03620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H8529_RS03625	COG1773	rubredoxin
H8529_RS03630	COG0375	protein maturation
H8529_RS03635	COG0298	carbon dioxide binding
H8529_RS03640	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS03645	COG0625	glutathione transferase activity
H8529_RS03650	COG0754	glutathionylspermidine amidase activity
H8529_RS03655	COG0306	phosphate transporter
H8529_RS03660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8529_RS03665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8529_RS03670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8529_RS03675	COG2244	polysaccharide biosynthetic process
H8529_RS03685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H8529_RS03690	COG0795	lipopolysaccharide-transporting ATPase activity
H8529_RS03700	COG0156	8-amino-7-oxononanoate synthase activity
H8529_RS03705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8529_RS03715	COG0318	PFAM AMP-dependent synthetase and ligase
H8529_RS03720	COG0456	acetyltransferase
H8529_RS03725	COG2186	Transcriptional regulator
H8529_RS03730	COG0277	FAD linked oxidase domain protein
H8529_RS03735	COG0277	FAD linked oxidase domain protein
H8529_RS03740	COG0247	lactate metabolic process
H8529_RS03745	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H8529_RS03750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8529_RS03755	COG1620	l-lactate permease
H8529_RS03760	COG3064	Membrane
H8529_RS03765	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8529_RS03785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8529_RS03790	COG1459	type II secretion system
H8529_RS03795	COG2165	general secretion pathway protein
H8529_RS03825	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H8529_RS03835	COG1811	Na channel or pump
H8529_RS03840	COG1982	Orn Lys Arg decarboxylase major
H8529_RS03845	COG2211	Major facilitator Superfamily
H8529_RS03860	COG1194	a g-specific adenine glycosylase
H8529_RS03870	COG3171	Protein conserved in bacteria
H8529_RS03880	COG0252	asparaginase activity
H8529_RS03890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8529_RS03905	COG0762	integral membrane protein
H8529_RS03910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8529_RS03915	COG2805	Type II/IV secretion system protein
H8529_RS03930	COG0189	ligase activity
H8529_RS03935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8529_RS03940	COG2356	endonuclease I
H8529_RS03950	COG2814	Major facilitator Superfamily
H8529_RS03970	COG1166	arginine decarboxylase activity
H8529_RS03985	COG0501	Belongs to the peptidase M48B family
H8529_RS03990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8529_RS03995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS04000	COG2213	PTS system mannitol-specific
H8529_RS04005	COG1063	alcohol dehydrogenase
H8529_RS04010	COG1494	fructose-1,6-bisphosphatase
H8529_RS04020	COG1072	(Pantothenic acid kinase))
H8529_RS04025	COG1122	ATPase activity
H8529_RS04030	COG1122	ATPase activity
H8529_RS04060	COG0191	fructose-bisphosphate aldolase activity
H8529_RS04065	COG0668	transmembrane transport
H8529_RS04075	COG2968	Membrane
H8529_RS04080	COG0583	DNA-binding transcription factor activity
H8529_RS04085	COG0427	acetyl-CoA hydrolase
H8529_RS04090	COG1024	Enoyl-CoA hydratase
H8529_RS04095	COG1703	isobutyryl-CoA mutase activity
H8529_RS04100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H8529_RS04100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H8529_RS04120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8529_RS04135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8529_RS04155	COG0006	proline dipeptidase activity
H8529_RS04160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8529_RS04165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8529_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS04195	COG2723	6-phospho-beta-galactosidase activity
H8529_RS04205	COG1272	protein, Hemolysin III
H8529_RS04215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H8529_RS04225	COG0716	FMN binding
H8529_RS04230	COG4974	Belongs to the 'phage' integrase family
H8529_RS04235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8529_RS04240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8529_RS04270	COG2233	PERMEase
H8529_RS04275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS04275	COG0493	'glutamate synthase
H8529_RS04280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS04285	COG2252	PERMEase
H8529_RS04290	COG0402	S-adenosylhomocysteine deaminase activity
H8529_RS04295	COG2233	PERMEase
H8529_RS04300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8529_RS04300	COG2080	2 iron, 2 sulfur cluster binding
H8529_RS04305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8529_RS04310	COG0402	S-adenosylhomocysteine deaminase activity
H8529_RS04315	COG0493	'glutamate synthase
H8529_RS04315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS04320	COG2068	MobA-Related Protein
H8529_RS04325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8529_RS04330	COG3608	succinylglutamate desuccinylase aspartoacylase
H8529_RS04330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8529_RS04335	COG0549	Belongs to the carbamate kinase family
H8529_RS04345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8529_RS04350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8529_RS04355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8529_RS04360	COG3829	transcription factor binding
H8529_RS04365	COG2080	2 iron, 2 sulfur cluster binding
H8529_RS04370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8529_RS04375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8529_RS04380	COG4942	peptidase
H8529_RS04390	COG3387	PFAM Glycoside hydrolase 15-related
H8529_RS04485	COG3710	Transcriptional regulator
H8529_RS04485	COG0457	Tetratricopeptide repeat
H8529_RS04490	COG0457	Tetratricopeptide repeat
H8529_RS04515	COG3710	Transcriptional regulator
H8529_RS04520	COG2771	luxR family
H8529_RS04525	COG0814	amino acid
H8529_RS04530	COG0183	Belongs to the thiolase family
H8529_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS04545	COG2814	Major facilitator Superfamily
H8529_RS04550	COG1794	racemase activity, acting on amino acids and derivatives
H8529_RS04555	COG0583	DNA-binding transcription factor activity
H8529_RS04565	COG1609	Transcriptional regulator
H8529_RS04580	COG0667	Aldo Keto reductase
H8529_RS04590	COG0861	Integral membrane protein TerC family
H8529_RS04605	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H8529_RS04620	COG2165	general secretion pathway protein
H8529_RS04625	COG4795	General secretion pathway protein
H8529_RS04635	COG4967	type IV pilus modification protein PilV
H8529_RS04640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H8529_RS04645	COG1025	Belongs to the peptidase M16 family
H8529_RS04650	COG1074	ATP-dependent DNA helicase activity
H8529_RS04655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8529_RS04660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H8529_RS04660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H8529_RS04665	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8529_RS04670	COG3711	transcriptional antiterminator
H8529_RS04675	COG1263	PTS System
H8529_RS04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS04680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H8529_RS04710	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H8529_RS04715	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS04720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8529_RS04725	COG2166	iron-sulfur cluster assembly
H8529_RS04730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8529_RS04740	COG0583	DNA-binding transcription factor activity
H8529_RS04745	COG2363	Small membrane protein
H8529_RS04755	COG1349	DNA-binding transcription factor activity
H8529_RS04765	COG1070	Carbohydrate kinase
H8529_RS04775	COG0738	Major facilitator superfamily
H8529_RS04780	COG0235	Class ii aldolase
H8529_RS04785	COG1454	alcohol dehydrogenase
H8529_RS04795	COG1760	l-serine dehydratase
H8529_RS04800	COG0814	amino acid
H8529_RS04805	COG1611	Belongs to the LOG family
H8529_RS04820	COG3098	single-species biofilm formation
H8529_RS04825	COG0564	pseudouridine synthase activity
H8529_RS04830	COG0716	FMN binding
H8529_RS04835	COG2271	Major facilitator Superfamily
H8529_RS04840	COG4948	Mandelate Racemase Muconate Lactonizing
H8529_RS04845	COG4948	Mandelate Racemase Muconate Lactonizing
H8529_RS04850	COG2205	protein histidine kinase activity
H8529_RS04850	COG3437	response regulator, receiver
H8529_RS04850	COG3850	Histidine kinase
H8529_RS04850	COG4999	Histidine kinase
H8529_RS04860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8529_RS04865	COG2336	PFAM SpoVT AbrB
H8529_RS04870	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8529_RS04875	COG3956	TIGRFAM MazG family protein
H8529_RS04895	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H8529_RS04905	COG0602	queuosine metabolic process
H8529_RS04910	COG1070	Carbohydrate kinase
H8529_RS04915	COG0720	synthase
H8529_RS04940	COG1203	CRISPR-associated helicase, Cas3
H8529_RS04955	COG1857	crispr-associated protein
H8529_RS04970	COG1518	maintenance of DNA repeat elements
H8529_RS04975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8529_RS04980	COG2234	aminopeptidase activity
H8529_RS05035	COG4942	peptidase
H8529_RS05035	COG1388	LysM domain
H8529_RS05040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8529_RS05055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8529_RS05065	COG2610	gluconate transmembrane transporter activity
H8529_RS05070	COG3622	Belongs to the hyi family
H8529_RS05075	COG0235	Class ii aldolase
H8529_RS05080	COG3395	kinase activity
H8529_RS05085	COG2084	Dehydrogenase
H8529_RS05090	COG1349	DNA-binding transcription factor activity
H8529_RS05095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8529_RS05115	COG3604	Transcriptional regulator
H8529_RS05120	COG0309	Hydrogenase expression formation protein (HypE)
H8529_RS05125	COG0409	Hydrogenase expression formation protein
H8529_RS05130	COG0298	carbon dioxide binding
H8529_RS05135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H8529_RS05140	COG0375	protein maturation
H8529_RS05150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS05155	COG0651	ATP synthesis coupled electron transport
H8529_RS05160	COG0650	Formate hydrogenlyase subunit 4
H8529_RS05165	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H8529_RS05165	COG3261	NADH dehydrogenase
H8529_RS05170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8529_RS05175	COG3260	NADH ubiquinone oxidoreductase 20
H8529_RS05185	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H8529_RS05195	COG5499	transcription regulator containing HTH domain
H8529_RS05200	COG2723	6-phospho-beta-galactosidase activity
H8529_RS05205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS05205	COG1263	PTS System
H8529_RS05210	COG1609	Transcriptional regulator
H8529_RS05215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS05220	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H8529_RS05240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H8529_RS05240	COG0517	IMP dehydrogenase activity
H8529_RS05245	COG1349	DNA-binding transcription factor activity
H8529_RS05250	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS05265	COG3732	PTS system glucitol sorbitol-specific
H8529_RS05270	COG3730	PTS system glucitol sorbitol-specific
H8529_RS05275	COG2951	lytic endotransglycosylase activity
H8529_RS05280	COG1546	Belongs to the CinA family
H8529_RS05300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8529_RS05330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8529_RS05335	COG1238	metal cluster binding
H8529_RS05350	COG2814	Major facilitator Superfamily
H8529_RS05355	COG1566	PFAM secretion protein HlyD family protein
H8529_RS05360	COG1846	Transcriptional regulator
H8529_RS05370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H8529_RS05375	COG2814	Major facilitator Superfamily
H8529_RS05380	COG2113	Glycine betaine
H8529_RS05385	COG4176	ABC-type proline glycine betaine transport system permease component
H8529_RS05390	COG4175	Glycine betaine
H8529_RS05395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8529_RS05400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8529_RS05410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8529_RS05415	COG4575	ribosome binding
H8529_RS05430	COG2916	Histone family protein nucleoid-structuring protein H-NS
H8529_RS05435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8529_RS05440	COG0640	Transcriptional regulator
H8529_RS05445	COG0401	homolog of Blt101
H8529_RS05450	COG1652	LysM domain
H8529_RS05455	COG1802	Transcriptional regulator
H8529_RS05460	COG1113	amino acid transport
H8529_RS05465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H8529_RS05470	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS05475	COG0579	oxidoreductase
H8529_RS05510	COG0582	viral genome integration into host DNA
H8529_RS05525	COG2867	negative regulation of translational initiation
H8529_RS05535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8529_RS05540	COG0497	DNA recombination
H8529_RS05555	COG4536	flavin adenine dinucleotide binding
H8529_RS05560	COG4137	Cytochrome C assembly protein
H8529_RS05565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8529_RS05590	COG2885	chlorophyll binding
H8529_RS05595	COG2199	diguanylate cyclase activity
H8529_RS05610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8529_RS05615	COG1605	Chorismate mutase
H8529_RS05615	COG0287	Prephenate dehydrogenase
H8529_RS05620	COG1605	Chorismate mutase
H8529_RS05620	COG0077	Prephenate dehydratase
H8529_RS05630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8529_RS05635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8529_RS05640	COG0564	pseudouridine synthase activity
H8529_RS05650	COG0542	response to heat
H8529_RS05675	COG0477	Major facilitator Superfamily
H8529_RS05680	COG5544	Lipoprotein
H8529_RS05685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8529_RS05690	COG1042	CoA-binding domain protein
H8529_RS05690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8529_RS05690	COG0045	succinate-CoA ligase (ADP-forming) activity
H8529_RS05695	COG3148	PFAM DTW domain containing protein
H8529_RS05700	COG3118	belongs to the thioredoxin family
H8529_RS05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8529_RS05725	COG0583	DNA-binding transcription factor activity
H8529_RS05730	COG0513	Belongs to the DEAD box helicase family
H8529_RS05740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8529_RS05750	COG1595	DNA-templated transcription, initiation
H8529_RS05755	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H8529_RS05760	COG3026	antisigma factor binding
H8529_RS05765	COG3086	response to oxidative stress
H8529_RS05775	COG0681	Belongs to the peptidase S26 family
H8529_RS05795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H8529_RS05810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS05820	COG0560	Phosphoserine phosphatase
H8529_RS05835	COG0047	phosphoribosylformylglycinamidine synthase activity
H8529_RS05835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8529_RS05840	COG2205	protein histidine kinase activity
H8529_RS05845	COG3170	Tfp pilus assembly protein FimV
H8529_RS05850	COG2204	response regulator
H8529_RS05855	COG0347	Belongs to the P(II) protein family
H8529_RS05860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8529_RS05860	COG1017	nitric oxide dioxygenase activity
H8529_RS05870	COG1940	carbohydrate kinase activity
H8529_RS05875	COG0457	Tetratricopeptide repeat
H8529_RS05880	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS05885	COG1129	ABC transporter
H8529_RS05890	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8529_RS05895	COG1063	alcohol dehydrogenase
H8529_RS05900	COG2017	converts alpha-aldose to the beta-anomer
H8529_RS05905	COG2259	Doxx family
H8529_RS05930	COG4638	Rieske (2fe-2S)
H8529_RS05935	COG0583	DNA-binding transcription factor activity
H8529_RS05940	COG2814	Major facilitator Superfamily
H8529_RS05945	COG3711	transcriptional antiterminator
H8529_RS05950	COG1073	alpha beta
H8529_RS05955	COG0483	inositol monophosphate 1-phosphatase activity
H8529_RS05975	COG0822	iron-sulfur transferase activity
H8529_RS05995	COG0633	Ferredoxin
H8529_RS06000	COG2975	iron-sulfur cluster assembly
H8529_RS06015	COG2897	thiosulfate sulfurtransferase activity
H8529_RS06020	COG2373	Large extracellular alpha-helical protein
H8529_RS06025	COG4953	penicillin-binding protein 1C
H8529_RS06055	COG2976	Protein conserved in bacteria
H8529_RS06070	COG1645	bacterial-type flagellum-dependent swarming motility
H8529_RS06080	COG0517	IMP dehydrogenase activity
H8529_RS06080	COG0516	GMP reductase activity
H8529_RS06095	COG3133	Outer membrane lipoprotein
H8529_RS06110	COG2200	EAL domain
H8529_RS06115	COG0248	Ppx GppA phosphatase
H8529_RS06120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H8529_RS06125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8529_RS06140	COG2233	PERMEase
H8529_RS06150	COG1393	Belongs to the ArsC family
H8529_RS06155	COG4783	chaperone-mediated protein folding
H8529_RS06160	COG0628	permease
H8529_RS06165	COG2116	formate transmembrane transporter activity
H8529_RS06170	COG3604	Transcriptional regulator
H8529_RS06185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8529_RS06190	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H8529_RS06190	COG3261	NADH dehydrogenase
H8529_RS06195	COG0651	ATP synthesis coupled electron transport
H8529_RS06200	COG4237	Hydrogenase 4 membrane
H8529_RS06210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8529_RS06215	COG0650	Formate hydrogenlyase subunit 4
H8529_RS06225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS06230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8529_RS06235	COG2716	regulation of RNA biosynthetic process
H8529_RS06245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H8529_RS06265	COG2321	neutral zinc metallopeptidase
H8529_RS06270	COG1444	tRNA N-acetyltransferase activity
H8529_RS06275	COG0400	carboxylic ester hydrolase activity
H8529_RS06290	COG1393	Belongs to the ArsC family
H8529_RS06300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8529_RS06305	COG3850	Histidine kinase
H8529_RS06310	COG0493	'glutamate synthase
H8529_RS06310	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS06320	COG5342	invasion associated locus B
H8529_RS06325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8529_RS06330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8529_RS06335	COG0280	phosphate acetyltransferase
H8529_RS06335	COG0281	malic enzyme
H8529_RS06340	COG4810	utilization protein
H8529_RS06345	COG4917	ethanolamine utilization protein
H8529_RS06350	COG4766	ethanolamine catabolic process
H8529_RS06355	COG4812	Cobalamin adenosyltransferase
H8529_RS06360	COG0280	phosphate acetyltransferase
H8529_RS06365	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8529_RS06370	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H8529_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS06385	COG1454	alcohol dehydrogenase
H8529_RS06390	COG3192	ethanolamine utilization protein
H8529_RS06395	COG4819	ethanolamine utilization protein
H8529_RS06400	COG4303	Ethanolamine ammonia lyase large subunit
H8529_RS06410	COG4816	utilization protein
H8529_RS06415	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8529_RS06420	COG2207	Transcriptional regulator
H8529_RS06430	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8529_RS06450	COG2837	iron assimilation
H8529_RS06455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8529_RS06460	COG1263	PTS System
H8529_RS06460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS06480	COG4150	thiosulfate binding
H8529_RS06485	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H8529_RS06490	COG4208	sulfate ABC transporter
H8529_RS06495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8529_RS06500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8529_RS06515	COG2190	(PTS) system
H8529_RS06520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8529_RS06525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS06530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8529_RS06550	COG3530	Putative quorum-sensing-regulated virulence factor
H8529_RS06555	COG0385	Bile acid
H8529_RS06560	COG0583	DNA-binding transcription factor activity
H8529_RS06570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8529_RS06575	COG2211	Major facilitator Superfamily
H8529_RS06585	COG0583	DNA-binding transcription factor activity
H8529_RS06620	COG3415	Transposase
H8529_RS06625	COG3415	Transposase
H8529_RS06640	COG2199	diguanylate cyclase activity
H8529_RS06640	COG2200	EAL domain
H8529_RS06645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8529_RS06670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS06675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS06680	COG0006	proline dipeptidase activity
H8529_RS06685	COG1363	Peptidase, m42
H8529_RS06695	COG2207	Transcriptional regulator
H8529_RS06700	COG3279	Response regulator of the LytR AlgR family
H8529_RS06705	COG3275	phosphorelay sensor kinase activity
H8529_RS06710	COG0436	Aminotransferase
H8529_RS06720	COG1560	Kdo2-lipid A biosynthetic process
H8529_RS06745	COG0028	Belongs to the TPP enzyme family
H8529_RS06750	COG0679	Auxin Efflux Carrier
H8529_RS06755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H8529_RS06760	COG0784	Response regulator, receiver
H8529_RS06760	COG2205	protein histidine kinase activity
H8529_RS06760	COG2198	Histidine kinase
H8529_RS06760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS06765	COG2197	response regulator
H8529_RS06770	COG1566	PFAM secretion protein HlyD family protein
H8529_RS06775	COG0477	Major facilitator Superfamily
H8529_RS06815	COG2116	formate transmembrane transporter activity
H8529_RS06820	COG2853	Lipoprotein
H8529_RS06830	COG2067	long-chain fatty acid transport protein
H8529_RS06835	COG3691	Protein conserved in bacteria
H8529_RS06850	COG2062	phosphohistidine phosphatase, SixA
H8529_RS06855	COG3539	Fimbrial protein
H8529_RS06860	COG3188	usher protein
H8529_RS06865	COG3121	Chaperone
H8529_RS06870	COG3539	Fimbrial protein
H8529_RS06875	COG3539	Fimbrial protein
H8529_RS06880	COG3539	Fimbrial protein
H8529_RS06910	COG0730	response to heat
H8529_RS06915	COG3101	peptidyl-lysine hydroxylation
H8529_RS06930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8529_RS06935	COG2814	Major facilitator Superfamily
H8529_RS06950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8529_RS06960	COG0586	Pfam SNARE associated Golgi protein
H8529_RS06970	COG0285	dihydrofolate synthase activity
H8529_RS06975	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H8529_RS06980	COG1286	toxin biosynthetic process
H8529_RS06985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8529_RS06990	COG0163	prenyltransferase activity
H8529_RS06995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS07005	COG4215	(ABC) transporter
H8529_RS07010	COG4160	amino acid transport
H8529_RS07015	COG4598	ABC transporter
H8529_RS07020	COG5464	transposase or invertase
H8529_RS07025	COG1090	epimerase
H8529_RS07030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8529_RS07035	COG0625	glutathione transferase activity
H8529_RS07040	COG0625	glutathione transferase activity
H8529_RS07045	COG0622	Phosphoesterase
H8529_RS07050	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H8529_RS07055	COG1288	antiporter activity
H8529_RS07060	COG0280	phosphate acetyltransferase
H8529_RS07060	COG0857	belongs to the CobB CobQ family
H8529_RS07065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8529_RS07080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8529_RS07085	COG0490	domain, Protein
H8529_RS07085	COG0471	metal ion transport
H8529_RS07095	COG0436	Aminotransferase
H8529_RS07100	COG0583	DNA-binding transcription factor activity
H8529_RS07120	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H8529_RS07125	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H8529_RS07130	COG1034	ATP synthesis coupled electron transport
H8529_RS07145	COG0839	Belongs to the complex I subunit 6 family
H8529_RS07155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8529_RS07160	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8529_RS07190	COG2153	protein acetylation
H8529_RS07195	COG4575	ribosome binding
H8529_RS07200	COG1169	isochorismate synthase
H8529_RS07215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8529_RS07225	COG0318	PFAM AMP-dependent synthetase and ligase
H8529_RS07295	COG5464	transposase or invertase
H8529_RS07300	COG0247	lactate metabolic process
H8529_RS07310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8529_RS07315	COG2271	Major facilitator Superfamily
H8529_RS07320	COG0584	glycerophosphoryl diester phosphodiesterase
H8529_RS07330	COG3642	lipopolysaccharide core region biosynthetic process
H8529_RS07335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8529_RS07340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8529_RS07345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8529_RS07350	COG3468	outer membrane autotransporter barrel domain protein
H8529_RS07360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8529_RS07365	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
H8529_RS07370	COG3234	Protein of unknown function (DUF1175)
H8529_RS07375	COG2373	Large extracellular alpha-helical protein
H8529_RS07380	COG5445	Predicted secreted protein (DUF2300)
H8529_RS07385	COG4676	Protein conserved in bacteria
H8529_RS07390	COG2205	protein histidine kinase activity
H8529_RS07390	COG0784	Response regulator, receiver
H8529_RS07395	COG2197	response regulator
H8529_RS07400	COG0642	Histidine kinase
H8529_RS07400	COG2198	Histidine kinase
H8529_RS07405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8529_RS07410	COG1477	protein flavinylation
H8529_RS07415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8529_RS07415	COG2169	Transcriptional regulator
H8529_RS07420	COG3145	DNA-N1-methyladenine dioxygenase activity
H8529_RS07425	COG4615	Cyclic peptide transporter
H8529_RS07440	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS07440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H8529_RS07445	COG3062	negative regulation of establishment of protein localization
H8529_RS07455	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS07460	COG0348	domain, Protein
H8529_RS07465	COG3043	anaerobic respiration
H8529_RS07470	COG3005	denitrification pathway
H8529_RS07475	COG4133	protoheme IX ABC transporter activity
H8529_RS07480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8529_RS07485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8529_RS07490	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8529_RS07500	COG1138	Cytochrome C-type biogenesis protein
H8529_RS07505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8529_RS07510	COG3088	subunit of a heme lyase
H8529_RS07510	COG4235	cytochrome complex assembly
H8529_RS07515	COG2197	response regulator
H8529_RS07530	COG3083	sulfuric ester hydrolase activity
H8529_RS07550	COG1061	Type III restriction enzyme res subunit
H8529_RS07555	COG1187	pseudouridine synthase activity
H8529_RS07560	COG2814	Major facilitator Superfamily
H8529_RS07570	COG4172	Belongs to the ABC transporter superfamily
H8529_RS07575	COG4239	(ABC) transporter, permease
H8529_RS07580	COG4174	ABC transporter (Permease)
H8529_RS07585	COG4166	transmembrane transport
H8529_RS07590	COG2200	EAL domain
H8529_RS07595	COG0791	NLP P60 protein
H8529_RS07600	COG0671	phosphoesterase, PA-phosphatase related
H8529_RS07605	COG0523	cobalamin synthesis protein
H8529_RS07610	COG0246	Mannitol dehydrogenase
H8529_RS07625	COG2814	Major facilitator Superfamily
H8529_RS07630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS07630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS07635	COG1105	Belongs to the carbohydrate kinase PfkB family
H8529_RS07640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS07640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS07640	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H8529_RS07645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS07650	COG2313	pseudouridylate synthase activity
H8529_RS07655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8529_RS07660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8529_RS07670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8529_RS07675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS07675	COG1522	sequence-specific DNA binding
H8529_RS07685	COG2855	membrane
H8529_RS07690	COG0583	DNA-binding transcription factor activity
H8529_RS07695	COG0833	amino acid
H8529_RS07700	COG4771	TonB-dependent receptor
H8529_RS07715	COG2311	Membrane
H8529_RS07720	COG1609	Transcriptional regulator
H8529_RS07725	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS07730	COG1129	ABC transporter
H8529_RS07735	COG4211	Belongs to the binding-protein-dependent transport system permease family
H8529_RS07740	COG0167	dihydroorotate dehydrogenase activity
H8529_RS07740	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H8529_RS07745	COG0493	'glutamate synthase
H8529_RS07755	COG2949	membrane
H8529_RS07765	COG1346	cytolysis
H8529_RS07775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8529_RS07790	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS07795	COG0586	Pfam SNARE associated Golgi protein
H8529_RS07805	COG1686	Belongs to the peptidase S11 family
H8529_RS07810	COG0277	FAD linked oxidase domain protein
H8529_RS07815	COG1472	Belongs to the glycosyl hydrolase 3 family
H8529_RS07820	COG1732	Glycine betaine
H8529_RS07825	COG1174	glycine betaine transport
H8529_RS07830	COG1125	glycine betaine transport
H8529_RS07835	COG1174	glycine betaine transport
H8529_RS07845	COG0789	Transcriptional regulator
H8529_RS07850	COG3275	phosphorelay sensor kinase activity
H8529_RS07855	COG3279	Response regulator of the LytR AlgR family
H8529_RS07860	COG4807	Protein conserved in bacteria
H8529_RS07865	COG4808	Protein conserved in bacteria
H8529_RS07870	COG4715	Zinc finger, swim domain protein
H8529_RS07875	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H8529_RS07880	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H8529_RS07885	COG0714	Associated with various cellular activities
H8529_RS07895	COG3831	ATPase activity
H8529_RS07910	COG0489	protein tyrosine kinase activity
H8529_RS07920	COG3539	Fimbrial protein
H8529_RS07925	COG3121	Chaperone
H8529_RS07930	COG3188	usher protein
H8529_RS07935	COG3539	Fimbrial protein
H8529_RS07940	COG5455	response to cobalt ion
H8529_RS07945	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H8529_RS07960	COG0351	phosphomethylpyrimidine kinase
H8529_RS07965	COG3757	hydrolase, family 25
H8529_RS07970	COG2188	Transcriptional regulator
H8529_RS07975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS07980	COG1397	ADP-ribosylglycohydrolase
H8529_RS07985	COG2211	Major facilitator Superfamily
H8529_RS07990	COG1830	Aldolase
H8529_RS08005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS08010	COG3414	Phosphotransferase system galactitol-specific IIB component
H8529_RS08015	COG3775	system Galactitol-specific IIC component
H8529_RS08020	COG1063	alcohol dehydrogenase
H8529_RS08040	COG4974	Belongs to the 'phage' integrase family
H8529_RS08105	COG4695	Portal protein
H8529_RS08200	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8529_RS08200	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8529_RS08255	COG0826	peptidase U32
H8529_RS08265	COG3609	addiction module antidote protein, CC2985 family
H8529_RS08275	COG0745	RESPONSE REGULATOR receiver
H8529_RS08280	COG2205	protein histidine kinase activity
H8529_RS08320	COG4245	von Willebrand factor, type A
H8529_RS08325	COG0631	protein serine/threonine phosphatase activity
H8529_RS08330	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
H8529_RS08335	COG0443	Heat shock 70 kDa protein
H8529_RS08340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8529_RS08345	COG3447	MASE1 domain protein
H8529_RS08345	COG5001	Diguanylate cyclase
H8529_RS08345	COG5002	protein histidine kinase activity
H8529_RS08350	COG0572	uridine kinase
H8529_RS08360	COG2982	Protein involved in outer membrane biogenesis
H8529_RS08375	COG1253	flavin adenine dinucleotide binding
H8529_RS08385	COG1596	polysaccharide export
H8529_RS08390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8529_RS08395	COG3206	protein involved in exopolysaccharide biosynthesis
H8529_RS08395	COG0489	protein tyrosine kinase activity
H8529_RS08400	COG0463	Glycosyl transferase, family 2
H8529_RS08405	COG1045	serine acetyltransferase
H8529_RS08410	COG0438	transferase activity, transferring glycosyl groups
H8529_RS08420	COG1216	Glycosyl transferase, family 2
H8529_RS08425	COG0110	maltose O-acetyltransferase activity
H8529_RS08430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H8529_RS08435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8529_RS08440	COG1051	belongs to the nudix hydrolase family
H8529_RS08445	COG0297	glycogen (starch) synthase activity
H8529_RS08450	COG0662	Cupin 2, conserved barrel domain protein
H8529_RS08450	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H8529_RS08455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8529_RS08460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8529_RS08465	COG2244	polysaccharide biosynthetic process
H8529_RS08470	COG2327	Polysaccharide pyruvyl transferase
H8529_RS08475	COG0438	transferase activity, transferring glycosyl groups
H8529_RS08485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8529_RS08535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8529_RS08565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8529_RS08570	COG0131	Imidazoleglycerol-phosphate dehydratase
H8529_RS08570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8529_RS08580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8529_RS08595	COG2161	toxin-antitoxin pair type II binding
H8529_RS08600	COG4115	mRNA cleavage
H8529_RS08605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8529_RS08610	COG0583	DNA-binding transcription factor activity
H8529_RS08620	COG0531	amino acid
H8529_RS08625	COG2391	methyltransferase activity
H8529_RS08630	COG0425	Belongs to the sulfur carrier protein TusA family
H8529_RS08635	COG2925	Exonuclease
H8529_RS08640	COG1686	Belongs to the peptidase S11 family
H8529_RS08650	COG1289	transmembrane transporter activity
H8529_RS08675	COG4656	Part of a membrane complex involved in electron transport
H8529_RS08680	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS08680	COG1454	alcohol dehydrogenase
H8529_RS08695	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H8529_RS08710	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H8529_RS08770	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
H8529_RS08785	COG1376	ErfK ybiS ycfS ynhG family protein
H8529_RS08795	COG0583	DNA-binding transcription factor activity
H8529_RS08800	COG0583	DNA-binding transcription factor activity
H8529_RS08810	COG0534	Mate efflux family protein
H8529_RS08820	COG0217	transcriptional regulatory protein
H8529_RS08825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8529_RS08830	COG0477	Major facilitator Superfamily
H8529_RS08860	COG3038	cytochrome b561
H8529_RS08865	COG3443	Belongs to the bacterial solute-binding protein 9 family
H8529_RS08880	COG2351	hydroxyisourate hydrolase activity
H8529_RS08885	COG0745	RESPONSE REGULATOR receiver
H8529_RS08890	COG2205	protein histidine kinase activity
H8529_RS08900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8529_RS08910	COG1418	mRNA catabolic process
H8529_RS08915	COG0270	DNA (cytosine-5-)-methyltransferase activity
H8529_RS08920	COG3727	T/G mismatch-specific endonuclease activity
H8529_RS08925	COG0697	spore germination
H8529_RS08935	COG5475	Uncharacterized small protein (DUF2158)
H8529_RS08960	COG2197	response regulator
H8529_RS08965	COG1684	flagellar biosynthetic protein fliR
H8529_RS08970	COG1987	bacterial-type flagellum assembly
H8529_RS08975	COG1338	Plays a role in the flagellum-specific transport system
H8529_RS08980	COG3190	flagellar
H8529_RS08985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8529_RS08990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8529_RS08995	COG1580	Controls the rotational direction of flagella during chemotaxis
H8529_RS09000	COG3144	bacterial-type flagellum assembly
H8529_RS09005	COG2882	bacterial-type flagellum organization
H8529_RS09010	COG1157	protein secretion by the type III secretion system
H8529_RS09015	COG1317	bacterial-type flagellum organization
H8529_RS09020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8529_RS09025	COG1766	The M ring may be actively involved in energy transduction
H8529_RS09035	COG2076	Multidrug Resistance protein
H8529_RS09040	COG1881	PFAM PEBP family protein
H8529_RS09045	COG2207	Transcriptional regulator
H8529_RS09055	COG0675	Transposase, IS605 OrfB family
H8529_RS09060	COG2135	peptidase activity
H8529_RS09065	COG0425	Belongs to the sulfur carrier protein TusA family
H8529_RS09070	COG2391	methyltransferase activity
H8529_RS09080	COG0366	Alpha amylase catalytic
H8529_RS09090	COG1516	flagellar protein fliS
H8529_RS09105	COG1191	sigma factor activity
H8529_RS09115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS09125	COG0765	amino acid transport
H8529_RS09130	COG1126	abc transporter atp-binding protein
H8529_RS09135	COG2197	response regulator
H8529_RS09150	COG2197	response regulator
H8529_RS09180	COG3318	Belongs to the UPF0149 family
H8529_RS09180	COG3012	SEC-C Motif Domain Protein
H8529_RS09185	COG0814	amino acid
H8529_RS09195	COG1528	Iron-storage protein
H8529_RS09215	COG1528	Iron-storage protein
H8529_RS09220	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS09225	COG1129	ABC transporter
H8529_RS09230	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8529_RS09235	COG1877	trehalose-phosphatase activity
H8529_RS09245	COG0589	response to stress
H8529_RS09260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8529_RS09265	COG1360	Flagellar Motor Protein
H8529_RS09270	COG2198	Histidine kinase
H8529_RS09270	COG0643	Histidine kinase
H8529_RS09275	COG0835	chemotaxis
H8529_RS09280	COG0840	transmembrane signaling receptor activity
H8529_RS09285	COG0840	transmembrane signaling receptor activity
H8529_RS09290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8529_RS09295	COG2201	protein-glutamate methylesterase activity
H8529_RS09300	COG0745	RESPONSE REGULATOR receiver
H8529_RS09305	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H8529_RS09310	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8529_RS09315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8529_RS09325	COG3755	Protein conserved in bacteria
H8529_RS09335	COG3102	Protein conserved in bacteria
H8529_RS09345	COG3005	denitrification pathway
H8529_RS09350	COG0243	molybdopterin cofactor binding
H8529_RS09365	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H8529_RS09370	COG1801	Protein of unknown function DUF72
H8529_RS09375	COG1335	isochorismatase
H8529_RS09385	COG0494	nUDIX hydrolase
H8529_RS09390	COG0217	transcriptional regulatory protein
H8529_RS09420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8529_RS09430	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H8529_RS09435	COG0739	heme binding
H8529_RS09440	COG1560	Kdo2-lipid A biosynthetic process
H8529_RS09460	COG3842	ATPase activity
H8529_RS09470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8529_RS09480	COG2182	Extracellular solute-binding protein
H8529_RS09490	COG3833	ABC-type maltose transport systems, permease component
H8529_RS09515	COG0469	pyruvate kinase activity
H8529_RS09520	COG1737	Transcriptional regulator
H8529_RS09525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8529_RS09530	COG0129	dihydroxy-acid dehydratase activity
H8529_RS09535	COG0800	Aldolase
H8529_RS09545	COG3141	response to X-ray
H8529_RS09555	COG2979	Protein of unknown function (DUF533)
H8529_RS09560	COG1770	oligopeptidase
H8529_RS09565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8529_RS09570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8529_RS09580	COG2372	response to copper ion
H8529_RS09585	COG1276	copper resistance
H8529_RS09595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8529_RS09615	COG3008	intermembrane lipid transfer
H8529_RS09620	COG2995	paraquat-inducible protein a
H8529_RS09625	COG1956	GAF domain-containing protein
H8529_RS09635	COG0793	Belongs to the peptidase S41A family
H8529_RS09645	COG2814	Major facilitator Superfamily
H8529_RS09650	COG1414	Transcriptional regulator
H8529_RS09680	COG2226	methyltransferase
H8529_RS09695	COG3716	PTS system mannose fructose sorbose family IID component
H8529_RS09700	COG3715	PTS system
H8529_RS09705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS09705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS09710	COG1253	flavin adenine dinucleotide binding
H8529_RS09715	COG2200	EAL domain
H8529_RS09720	COG1760	l-serine dehydratase
H8529_RS09730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8529_RS09745	COG0251	oxidation-reduction process
H8529_RS09750	COG1199	ATP-dependent helicase activity
H8529_RS09755	COG1214	PFAM Peptidase M22, glycoprotease
H8529_RS09760	COG3065	identical protein binding
H8529_RS09765	COG0318	PFAM AMP-dependent synthetase and ligase
H8529_RS09770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H8529_RS09775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8529_RS09780	COG4638	Rieske (2fe-2S)
H8529_RS09785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8529_RS09790	COG0473	3-isopropylmalate dehydrogenase activity
H8529_RS09795	COG0583	DNA-binding transcription factor activity
H8529_RS09805	COG3615	Tellurite resistance protein tehB
H8529_RS09820	COG0675	Transposase, IS605 OrfB family
H8529_RS09825	COG2261	transglycosylase associated protein
H8529_RS09840	COG2199	diguanylate cyclase activity
H8529_RS09840	COG2203	Gaf domain
H8529_RS09845	COG3042	response to heat
H8529_RS09850	COG3189	MarR family transcriptional regulator
H8529_RS09855	COG2807	transmembrane transport
H8529_RS09860	COG2207	Transcriptional regulator
H8529_RS09875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8529_RS09880	COG2199	diguanylate cyclase activity
H8529_RS09885	COG2199	diguanylate cyclase activity
H8529_RS09895	COG2766	serine protein kinase
H8529_RS09900	COG3713	MltA-interacting MipA family protein
H8529_RS09905	COG0656	L-ascorbic acid biosynthetic process
H8529_RS09910	COG0676	glucose-6-phosphate 1-epimerase activity
H8529_RS09915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8529_RS09925	COG3139	Protein of unknown function (DUF1315)
H8529_RS09930	COG1335	isochorismatase
H8529_RS09935	COG0252	asparaginase activity
H8529_RS09940	COG0616	signal peptide processing
H8529_RS09945	COG0778	Nitroreductase
H8529_RS09955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8529_RS09965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8529_RS09975	COG0494	nUDIX hydrolase
H8529_RS09980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8529_RS09985	COG2897	thiosulfate sulfurtransferase activity
H8529_RS09990	COG4136	ATPase activity
H8529_RS09995	COG4135	transport system, permease component
H8529_RS10000	COG4134	Bacterial extracellular solute-binding protein
H8529_RS10005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8529_RS10010	COG0398	Pfam SNARE associated Golgi protein
H8529_RS10020	COG0398	Pfam SNARE associated Golgi protein
H8529_RS10025	COG0708	Exodeoxyribonuclease III
H8529_RS10055	COG3678	ATP-independent chaperone mediated protein folding
H8529_RS10065	COG0322	excinuclease ABC activity
H8529_RS10075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8529_RS10080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8529_RS10085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8529_RS10090	COG1447	Phosphotransferase system cellobiose-specific component IIA
H8529_RS10095	COG1917	Cupin 2, conserved barrel domain protein
H8529_RS10095	COG2169	Transcriptional regulator
H8529_RS10100	COG1486	melibiose metabolic process
H8529_RS10110	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS10115	COG0753	catalase activity
H8529_RS10135	COG1823	symporter activity
H8529_RS10140	COG1988	membrane-bound metal-dependent
H8529_RS10145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8529_RS10155	COG3001	Fructosamine kinase
H8529_RS10165	COG1105	Belongs to the carbohydrate kinase PfkB family
H8529_RS10170	COG3137	Salt-induced outer membrane protein
H8529_RS10230	COG0386	Belongs to the glutathione peroxidase family
H8529_RS10240	COG0791	NLP P60 protein
H8529_RS10245	COG2200	EAL domain
H8529_RS10255	COG4256	Hemin uptake protein
H8529_RS10260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8529_RS10270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8529_RS10270	COG0574	Belongs to the PEP-utilizing enzyme family
H8529_RS10275	COG0318	PFAM AMP-dependent synthetase and ligase
H8529_RS10280	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H8529_RS10285	COG0644	oxidoreductase
H8529_RS10290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H8529_RS10295	COG2086	electron transfer activity
H8529_RS10300	COG1917	Cupin 2, conserved barrel domain protein
H8529_RS10300	COG2207	Transcriptional regulator
H8529_RS10305	COG1960	acyl-CoA dehydrogenase activity
H8529_RS10310	COG4670	ketone body catabolic process
H8529_RS10325	COG2271	Major facilitator Superfamily
H8529_RS10330	COG0738	Major facilitator superfamily
H8529_RS10345	COG0628	permease
H8529_RS10350	COG0247	lactate metabolic process
H8529_RS10350	COG0277	FAD linked oxidase domain protein
H8529_RS10355	COG2050	protein possibly involved in aromatic compounds catabolism
H8529_RS10365	COG0316	Belongs to the HesB IscA family
H8529_RS10370	COG0719	Fe-S assembly protein
H8529_RS10375	COG0396	ATPase activity
H8529_RS10380	COG0719	Fe-S assembly protein
H8529_RS10395	COG1376	ErfK ybiS ycfS ynhG family protein
H8529_RS10400	COG4238	major outer membrane lipoprotein
H8529_RS10405	COG0469	pyruvate kinase activity
H8529_RS10415	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS10420	COG2414	aldehyde ferredoxin oxidoreductase
H8529_RS10430	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS10435	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H8529_RS10445	COG4529	Protein conserved in bacteria
H8529_RS10465	COG3468	outer membrane autotransporter barrel domain protein
H8529_RS10475	COG0307	riboflavin synthase, alpha
H8529_RS10480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H8529_RS10485	COG2814	Major facilitator Superfamily
H8529_RS10490	COG0583	DNA-binding transcription factor activity
H8529_RS10505	COG2814	Major facilitator Superfamily
H8529_RS10510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8529_RS10515	COG0791	NLP P60 protein
H8529_RS10520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H8529_RS10525	COG1201	RNA secondary structure unwinding
H8529_RS10535	COG0346	lactoylglutathione lyase activity
H8529_RS10540	COG1902	pentaerythritol trinitrate reductase activity
H8529_RS10545	COG1309	transcriptional regulator
H8529_RS10550	COG3313	Fe-S protein
H8529_RS10555	COG4989	oxidoreductase activity
H8529_RS10560	COG2032	superoxide dismutase activity
H8529_RS10565	COG1289	transmembrane transporter activity
H8529_RS10570	COG1566	PFAM secretion protein HlyD family protein
H8529_RS10585	COG3133	Outer membrane lipoprotein
H8529_RS10595	COG3895	Periplasmic Protein
H8529_RS10610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H8529_RS10615	COG0625	glutathione transferase activity
H8529_RS10620	COG3104	oligopeptide transport
H8529_RS10625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8529_RS10635	COG4659	FMN binding
H8529_RS10675	COG0673	inositol 2-dehydrogenase activity
H8529_RS10685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H8529_RS10690	COG1263	PTS System
H8529_RS10690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS10695	COG1609	Transcriptional regulator
H8529_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS10705	COG1309	transcriptional regulator
H8529_RS10710	COG3250	beta-galactosidase activity
H8529_RS10725	COG5339	Protein conserved in bacteria
H8529_RS10730	COG1482	cell wall glycoprotein biosynthetic process
H8529_RS10735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H8529_RS10735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H8529_RS10740	COG0114	fumarate hydratase activity
H8529_RS10750	COG2205	protein histidine kinase activity
H8529_RS10755	COG0745	RESPONSE REGULATOR receiver
H8529_RS10760	COG3136	membrane protein required for alginate biosynthesis
H8529_RS10770	COG0531	amino acid
H8529_RS10780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H8529_RS10785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8529_RS10790	COG0628	permease
H8529_RS10805	COG3591	Belongs to the peptidase S1B family
H8529_RS10820	COG2814	Major facilitator Superfamily
H8529_RS10825	COG0583	DNA-binding transcription factor activity
H8529_RS10830	COG1940	carbohydrate kinase activity
H8529_RS10835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8529_RS10845	COG3381	protein complex oligomerization
H8529_RS10850	COG3302	dmso reductase anchor subunit
H8529_RS10855	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS10865	COG0243	molybdopterin cofactor binding
H8529_RS10880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8529_RS10895	COG4948	Mandelate Racemase Muconate Lactonizing
H8529_RS10900	COG1063	alcohol dehydrogenase
H8529_RS10910	COG0582	viral genome integration into host DNA
H8529_RS10920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8529_RS10950	COG1396	sequence-specific DNA binding
H8529_RS10965	COG1846	Transcriptional regulator
H8529_RS10995	COG1403	HNH endonuclease
H8529_RS11020	COG3179	chitinase
H8529_RS11055	COG0740	serine-type endopeptidase activity
H8529_RS11130	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8529_RS11135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8529_RS11140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8529_RS11160	COG0246	Mannitol dehydrogenase
H8529_RS11170	COG1802	Transcriptional regulator
H8529_RS11175	COG4221	oxidoreductase activity
H8529_RS11180	COG0339	signal peptide processing
H8529_RS11185	COG1546	Belongs to the CinA family
H8529_RS11190	COG3111	PFAM Bacterial OB fold (BOF) protein
H8529_RS11195	COG3706	GGDEF domain
H8529_RS11205	COG2814	Major facilitator Superfamily
H8529_RS11210	COG0697	spore germination
H8529_RS11215	COG2188	Transcriptional regulator
H8529_RS11225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8529_RS11230	COG1447	Phosphotransferase system cellobiose-specific component IIA
H8529_RS11240	COG2723	6-phospho-beta-galactosidase activity
H8529_RS11250	COG4977	sequence-specific DNA binding
H8529_RS11255	COG1846	Transcriptional regulator
H8529_RS11275	COG0583	DNA-binding transcription factor activity
H8529_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS11285	COG2066	Belongs to the glutaminase family
H8529_RS11295	COG2199	diguanylate cyclase activity
H8529_RS11305	COG3781	membrane
H8529_RS11355	COG3210	domain, Protein
H8529_RS11355	COG2911	Protein conserved in bacteria
H8529_RS11360	COG1396	sequence-specific DNA binding
H8529_RS11365	COG3550	peptidyl-serine autophosphorylation
H8529_RS11375	COG3539	Fimbrial protein
H8529_RS11385	COG3188	usher protein
H8529_RS11390	COG3539	Fimbrial protein
H8529_RS11395	COG3539	Fimbrial protein
H8529_RS11400	COG3539	Fimbrial protein
H8529_RS11405	COG0243	molybdopterin cofactor binding
H8529_RS11415	COG2207	Transcriptional regulator
H8529_RS11420	COG3119	arylsulfatase activity
H8529_RS11425	COG0641	radical SAM
H8529_RS11435	COG4178	(ABC) transporter
H8529_RS11440	COG4771	TonB-dependent receptor
H8529_RS11445	COG0612	Peptidase, M16
H8529_RS11450	COG0076	glutamate decarboxylase activity
H8529_RS11455	COG0531	amino acid
H8529_RS11460	COG1649	PFAM Uncharacterised BCR, COG1649
H8529_RS11470	COG2199	diguanylate cyclase activity
H8529_RS11470	COG2202	Pas domain
H8529_RS11470	COG2200	EAL domain
H8529_RS11475	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H8529_RS11480	COG0747	negative chemotaxis
H8529_RS11485	COG0601	transmembrane transport
H8529_RS11490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8529_RS11495	COG0444	Belongs to the ABC transporter superfamily
H8529_RS11500	COG4608	Belongs to the ABC transporter superfamily
H8529_RS11510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8529_RS11515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8529_RS11525	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8529_RS11530	COG2610	gluconate transmembrane transporter activity
H8529_RS11535	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS11540	COG1764	response to oxidative stress
H8529_RS11560	COG1064	alcohol dehydrogenase
H8529_RS11565	COG3093	addiction module antidote protein HigA
H8529_RS11570	COG2864	formate dehydrogenase
H8529_RS11575	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS11585	COG0697	spore germination
H8529_RS11590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8529_RS11595	COG4886	Leucine-rich repeat (LRR) protein
H8529_RS11600	COG2223	nitrite transmembrane transporter activity
H8529_RS11605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H8529_RS11610	COG1140	nitrate reductase beta subunit
H8529_RS11615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H8529_RS11620	COG2181	nitrate reductase activity
H8529_RS11625	COG0384	phenazine biosynthesis protein PhzF
H8529_RS11630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H8529_RS11635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8529_RS11690	COG3209	COG3209 Rhs family protein
H8529_RS11705	COG0625	glutathione transferase activity
H8529_RS11710	COG1113	amino acid transport
H8529_RS11715	COG3391	amine dehydrogenase activity
H8529_RS11720	COG4772	TonB-dependent receptor
H8529_RS11725	COG1802	Transcriptional regulator
H8529_RS11730	COG2130	NADP-dependent
H8529_RS11735	COG1247	-acetyltransferase
H8529_RS11745	COG2801	Transposase and inactivated derivatives
H8529_RS11750	COG2963	transposase activity
H8529_RS11785	COG1177	transmembrane transport
H8529_RS11790	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8529_RS11795	COG3842	ATPase activity
H8529_RS11800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8529_RS11805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8529_RS11810	COG1598	PFAM Uncharacterised protein family UPF0150
H8529_RS11815	COG1724	mRNA binding
H8529_RS11825	COG0826	peptidase U32
H8529_RS11830	COG1396	sequence-specific DNA binding
H8529_RS11835	COG3135	benzoate transporter
H8529_RS11840	COG0675	Transposase, IS605 OrfB family
H8529_RS11855	COG0500	methyltransferase
H8529_RS11860	COG1275	C4-dicarboxylate transporter malic acid transport protein
H8529_RS11865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8529_RS11870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8529_RS11875	COG2841	Protein conserved in bacteria
H8529_RS11885	COG5383	Protein conserved in bacteria
H8529_RS11890	COG0583	DNA-binding transcription factor activity
H8529_RS11895	COG0840	transmembrane signaling receptor activity
H8529_RS11910	COG3038	cytochrome b561
H8529_RS11915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8529_RS11920	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS11925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H8529_RS11930	COG1643	Atp-dependent helicase
H8529_RS11940	COG0671	phosphoesterase, PA-phosphatase related
H8529_RS11940	COG2453	phosphatase
H8529_RS11945	COG2267	carboxylic ester hydrolase activity
H8529_RS11950	COG4589	Belongs to the CDS family
H8529_RS11955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8529_RS11965	COG0667	Aldo Keto reductase
H8529_RS11970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8529_RS11975	COG3327	negative regulation of DNA-templated transcription, initiation
H8529_RS11980	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H8529_RS11985	COG0183	Belongs to the thiolase family
H8529_RS11990	COG2050	protein possibly involved in aromatic compounds catabolism
H8529_RS11995	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8529_RS12000	COG1024	Enoyl-CoA hydratase
H8529_RS12005	COG1024	Enoyl-CoA hydratase
H8529_RS12010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8529_RS12015	COG2151	metal-sulfur cluster biosynthetic enzyme
H8529_RS12020	COG3396	Phenylacetate-CoA oxygenase
H8529_RS12025	COG3460	Phenylacetate-CoA oxygenase
H8529_RS12030	COG3396	Phenylacetate-CoA oxygenase
H8529_RS12035	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS12035	COG2030	dehydratase
H8529_RS12040	COG3733	amine oxidase
H8529_RS12045	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS12050	COG2207	Transcriptional regulator
H8529_RS12055	COG3784	Protein of unknown function (DUF1318)
H8529_RS12065	COG2911	Protein conserved in bacteria
H8529_RS12070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8529_RS12075	COG3187	Heat shock protein
H8529_RS12080	COG3042	response to heat
H8529_RS12085	COG1013	pyruvate-flavodoxin oxidoreductase activity
H8529_RS12085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8529_RS12085	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8529_RS12085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H8529_RS12090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8529_RS12095	COG0589	response to stress
H8529_RS12105	COG1121	(ABC) transporter
H8529_RS12110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8529_RS12115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8529_RS12120	COG2199	diguanylate cyclase activity
H8529_RS12125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8529_RS12130	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8529_RS12165	COG1196	nuclear chromosome segregation
H8529_RS12245	COG1475	DNA binding
H8529_RS12250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8529_RS12260	COG3772	lysozyme
H8529_RS12275	COG3064	Membrane
H8529_RS12305	COG1846	Transcriptional regulator
H8529_RS12310	COG1484	DNA-dependent DNA replication
H8529_RS12315	COG3756	Protein conserved in bacteria
H8529_RS12365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8529_RS12370	COG3723	Recombinational DNA repair protein, rece pathway
H8529_RS12390	COG0582	viral genome integration into host DNA
H8529_RS12400	COG0513	Belongs to the DEAD box helicase family
H8529_RS12410	COG3706	GGDEF domain
H8529_RS12415	COG2840	Smr protein MutS2
H8529_RS12420	COG0583	DNA-binding transcription factor activity
H8529_RS12425	COG1473	amidohydrolase
H8529_RS12430	COG1473	amidohydrolase
H8529_RS12435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H8529_RS12440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8529_RS12445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8529_RS12450	COG0589	response to stress
H8529_RS12455	COG3182	Iron-regulated membrane protein
H8529_RS12460	COG0668	transmembrane transport
H8529_RS12465	COG4166	transmembrane transport
H8529_RS12470	COG0583	DNA-binding transcription factor activity
H8529_RS12475	COG1073	alpha beta
H8529_RS12480	COG1073	alpha beta
H8529_RS12485	COG0702	epimerase
H8529_RS12490	COG2866	Carboxypeptidase
H8529_RS12495	COG4948	Mandelate Racemase Muconate Lactonizing
H8529_RS12500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H8529_RS12505	COG3283	Transcriptional regulator of aromatic amino acids metabolism
H8529_RS12515	COG3106	COG3106 Predicted ATPase
H8529_RS12520	COG1609	Transcriptional regulator
H8529_RS12530	COG3842	ATPase activity
H8529_RS12535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8529_RS12540	COG1554	hydrolase, family 65, central catalytic
H8529_RS12545	COG0673	inositol 2-dehydrogenase activity
H8529_RS12550	COG1082	Xylose isomerase domain protein TIM barrel
H8529_RS12555	COG1063	alcohol dehydrogenase
H8529_RS12560	COG0395	ABC-type sugar transport system, permease component
H8529_RS12565	COG1175	transmembrane transport
H8529_RS12570	COG1653	transport
H8529_RS12575	COG0366	Alpha amylase catalytic
H8529_RS12580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8529_RS12590	COG1983	PspC domain protein
H8529_RS12600	COG1842	Phage shock protein A
H8529_RS12605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H8529_RS12610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H8529_RS12615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8529_RS12620	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS12625	COG1396	sequence-specific DNA binding
H8529_RS12625	COG1917	Cupin 2, conserved barrel domain protein
H8529_RS12630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H8529_RS12635	COG0174	glutamine synthetase
H8529_RS12645	COG0531	amino acid
H8529_RS12655	COG4166	transmembrane transport
H8529_RS12660	COG4168	peptide transport system, permease
H8529_RS12665	COG4171	peptide transport system, permease
H8529_RS12670	COG4172	Belongs to the ABC transporter superfamily
H8529_RS12675	COG4172	Belongs to the ABC transporter superfamily
H8529_RS12680	COG2852	Protein conserved in bacteria
H8529_RS12685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8529_RS12690	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8529_RS12690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8529_RS12705	COG5001	Diguanylate cyclase
H8529_RS12715	COG1349	DNA-binding transcription factor activity
H8529_RS12725	COG0023	Translation Initiation Factor
H8529_RS12735	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H8529_RS12740	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H8529_RS12745	COG0671	phosphoesterase, PA-phosphatase related
H8529_RS12755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H8529_RS12775	COG0583	DNA-binding transcription factor activity
H8529_RS12780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8529_RS12790	COG0616	signal peptide processing
H8529_RS12795	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS12800	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H8529_RS12805	COG1187	pseudouridine synthase activity
H8529_RS12835	COG0009	L-threonylcarbamoyladenylate synthase
H8529_RS12840	COG0613	PHP domain protein
H8529_RS12850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8529_RS12855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8529_RS12855	COG0512	Glutamine amidotransferase of anthranilate synthase
H8529_RS12860	COG0135	phosphoribosylanthranilate isomerase activity
H8529_RS12860	COG0134	indole-3-glycerol-phosphate synthase activity
H8529_RS12875	COG3729	General stress protein
H8529_RS12880	COG3685	Protein conserved in bacteria
H8529_RS12885	COG3685	Protein conserved in bacteria
H8529_RS12890	COG3047	cAMP biosynthetic process
H8529_RS12910	COG1607	acyl-coa hydrolase
H8529_RS12920	COG2350	Protein conserved in bacteria
H8529_RS12925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8529_RS12945	COG4608	Belongs to the ABC transporter superfamily
H8529_RS12950	COG0444	Belongs to the ABC transporter superfamily
H8529_RS12955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8529_RS12960	COG0601	transmembrane transport
H8529_RS12965	COG4166	transmembrane transport
H8529_RS12975	COG2095	MarC family integral membrane protein
H8529_RS12980	COG1454	alcohol dehydrogenase
H8529_RS12980	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS12990	COG1435	thymidine kinase activity
H8529_RS13000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8529_RS13005	COG0745	RESPONSE REGULATOR receiver
H8529_RS13010	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8529_RS13020	COG0788	formyltetrahydrofolate deformylase activity
H8529_RS13045	COG2181	nitrate reductase activity
H8529_RS13050	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H8529_RS13055	COG1140	nitrate reductase beta subunit
H8529_RS13060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H8529_RS13065	COG2223	nitrite transmembrane transporter activity
H8529_RS13070	COG3850	Histidine kinase
H8529_RS13075	COG2197	response regulator
H8529_RS13080	COG4932	domain protein
H8529_RS13085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H8529_RS13090	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H8529_RS13095	COG4572	Cation transport regulator
H8529_RS13100	COG0387	Pfam Sodium calcium exchanger
H8529_RS13125	COG2912	Transglutaminase-like superfamily
H8529_RS13130	COG3094	Invasion gene expression up-regulator, SirB
H8529_RS13135	COG2890	protein-(glutamine-N5) methyltransferase activity
H8529_RS13160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8529_RS13165	COG0659	secondary active sulfate transmembrane transporter activity
H8529_RS13180	COG0012	GTP binding
H8529_RS13185	COG3468	outer membrane autotransporter barrel domain protein
H8529_RS13190	COG3284	Transcriptional regulator
H8529_RS13195	COG2376	Dihydroxyacetone kinase
H8529_RS13200	COG1461	Dihydroxyacetone kinase
H8529_RS13205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS13205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8529_RS13205	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H8529_RS13225	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H8529_RS13235	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8529_RS13245	COG2963	transposase activity
H8529_RS13250	COG2801	Transposase and inactivated derivatives
H8529_RS13255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8529_RS13265	COG2719	SpoVR family
H8529_RS13285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8529_RS13290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8529_RS13305	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8529_RS13330	COG2894	cell division
H8529_RS13385	COG2200	EAL domain
H8529_RS13410	COG2200	EAL domain
H8529_RS13415	COG0789	Transcriptional regulator
H8529_RS13420	COG5562	phage envelope protein
H8529_RS13440	COG0538	isocitrate dehydrogenase activity
H8529_RS13445	COG1187	pseudouridine synthase activity
H8529_RS13465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8529_RS13475	COG2205	protein histidine kinase activity
H8529_RS13480	COG2850	peptidyl-arginine hydroxylation
H8529_RS13500	COG1177	transmembrane transport
H8529_RS13505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8529_RS13515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H8529_RS13520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8529_RS13530	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8529_RS13535	COG1136	(ABC) transporter
H8529_RS13540	COG4591	ABC-type transport system involved in lipoprotein release permease component
H8529_RS13545	COG4763	Acyl-transferase
H8529_RS13550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8529_RS13555	COG1376	ErfK ybiS ycfS ynhG family protein
H8529_RS13555	COG1388	LysM domain
H8529_RS13565	COG1309	transcriptional regulator
H8529_RS13570	COG3134	Outer membrane lipoprotein
H8529_RS13575	COG1252	NADH dehydrogenase
H8529_RS13595	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H8529_RS13600	COG5633	Lipoprotein
H8529_RS13605	COG0537	adenosine 5'-monophosphoramidase activity
H8529_RS13610	COG4773	Receptor
H8529_RS13615	COG1263	PTS System
H8529_RS13615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS13620	COG0084	hydrolase, TatD family'
H8529_RS13625	COG0470	DNA polymerase III
H8529_RS13635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8529_RS13640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8529_RS13645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8529_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS13660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8529_RS13680	COG1399	metal-binding, possibly nucleic acid-binding protein
H8529_RS13685	COG0424	maF-like protein
H8529_RS13690	COG0564	pseudouridine synthase activity
H8529_RS13695	COG1530	ribonuclease E activity
H8529_RS13700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8529_RS13705	COG1256	bacterial-type flagellum assembly
H8529_RS13710	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8529_RS13710	COG3951	Flagellar rod assembly protein muramidase FlgJ
H8529_RS13725	COG4786	Flagellar basal body rod
H8529_RS13730	COG4787	bacterial-type flagellum-dependent cell motility
H8529_RS13735	COG1749	Flagellar hook protein flgE
H8529_RS13740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8529_RS13745	COG1558	bacterial-type flagellum-dependent cell motility
H8529_RS13750	COG1815	bacterial-type flagellum-dependent cell motility
H8529_RS13755	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H8529_RS13760	COG2747	anti-sigma28 factor FlgM
H8529_RS13765	COG3418	PFAM FlgN family protein
H8529_RS13770	COG0728	peptidoglycan biosynthetic process
H8529_RS13775	COG0673	inositol 2-dehydrogenase activity
H8529_RS13785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8529_RS13795	COG2999	glutathione oxidoreductase activity
H8529_RS13830	COG3038	cytochrome b561
H8529_RS13835	COG2353	YceI-like domain
H8529_RS13845	COG1560	Kdo2-lipid A biosynthetic process
H8529_RS13860	COG5645	(Lipo)protein
H8529_RS13865	COG2943	transferase activity, transferring hexosyl groups
H8529_RS13880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8529_RS13885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8529_RS13910	COG2197	response regulator
H8529_RS13925	COG1462	curli production assembly transport component CsgG
H8529_RS13935	COG3381	protein complex oligomerization
H8529_RS13975	COG3706	GGDEF domain
H8529_RS13980	COG0457	Tetratricopeptide repeat
H8529_RS13985	COG1649	PFAM Uncharacterised BCR, COG1649
H8529_RS13985	COG0726	polysaccharide deacetylase
H8529_RS13990	COG1215	transferase activity, transferring glycosyl groups
H8529_RS13995	COG3658	cytochrome
H8529_RS14000	COG1702	phosphate starvation-inducible protein PhoH
H8529_RS14010	COG2822	iron ion transport
H8529_RS14020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8529_RS14030	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H8529_RS14030	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H8529_RS14030	COG0506	proline dehydrogenase activity
H8529_RS14035	COG1309	transcriptional regulator
H8529_RS14070	COG2233	PERMEase
H8529_RS14075	COG3729	General stress protein
H8529_RS14115	COG0243	molybdopterin cofactor binding
H8529_RS14120	COG3005	denitrification pathway
H8529_RS14125	COG0745	RESPONSE REGULATOR receiver
H8529_RS14130	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS14135	COG2198	Histidine kinase
H8529_RS14135	COG2205	protein histidine kinase activity
H8529_RS14135	COG0784	Response regulator, receiver
H8529_RS14140	COG0348	domain, Protein
H8529_RS14160	COG1278	Cold shock
H8529_RS14165	COG1278	Cold shock
H8529_RS14185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8529_RS14190	COG1596	polysaccharide export
H8529_RS14195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8529_RS14200	COG0489	protein tyrosine kinase activity
H8529_RS14200	COG3206	protein involved in exopolysaccharide biosynthesis
H8529_RS14215	COG1294	oxidase, subunit
H8529_RS14220	COG1271	oxidase subunit
H8529_RS14225	COG1773	rubredoxin
H8529_RS14230	COG1999	signal sequence binding
H8529_RS14235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H8529_RS14240	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H8529_RS14245	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H8529_RS14250	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H8529_RS14260	COG0670	Belongs to the BI1 family
H8529_RS14265	COG2920	part of a sulfur-relay system
H8529_RS14270	COG1254	Belongs to the acylphosphatase family
H8529_RS14285	COG1832	CoA-binding protein
H8529_RS14300	COG0210	DNA helicase
H8529_RS14305	COG3304	Inner membrane component domain
H8529_RS14310	COG1289	transmembrane transporter activity
H8529_RS14315	COG3070	regulator of competence-specific genes
H8529_RS14335	COG1067	ATP-dependent peptidase activity
H8529_RS14345	COG3130	regulation of translation
H8529_RS14350	COG3009	Protein conserved in bacteria
H8529_RS14355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H8529_RS14355	COG3008	intermembrane lipid transfer
H8529_RS14360	COG2995	paraquat-inducible protein a
H8529_RS14365	COG0488	(ABC) transporter
H8529_RS14375	COG0633	Ferredoxin
H8529_RS14375	COG3217	Mosc domain protein beta barrel domain protein
H8529_RS14390	COG3121	Chaperone
H8529_RS14395	COG3539	Fimbrial protein
H8529_RS14400	COG3539	Fimbrial protein
H8529_RS14405	COG3539	Fimbrial protein
H8529_RS14410	COG3188	usher protein
H8529_RS14415	COG3121	Chaperone
H8529_RS14420	COG3539	Fimbrial protein
H8529_RS14425	COG0431	NADPH-dependent FMN reductase
H8529_RS14430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8529_RS14440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8529_RS14450	COG0308	aminopeptidase N
H8529_RS14470	COG1448	Aminotransferase
H8529_RS14475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8529_RS14480	COG3108	Peptidase M15
H8529_RS14485	COG2989	Protein conserved in bacteria
H8529_RS14495	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H8529_RS14505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8529_RS14510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H8529_RS14515	COG3173	Aminoglycoside phosphotransferase
H8529_RS14530	COG3214	Protein conserved in bacteria
H8529_RS14540	COG1132	(ABC) transporter
H8529_RS14545	COG0658	competence protein
H8529_RS14545	COG2333	competence protein COMEC
H8529_RS14555	COG0539	negative regulation of cytoplasmic translation
H8529_RS14565	COG0501	Belongs to the peptidase M48B family
H8529_RS14580	COG2323	membrane
H8529_RS14585	COG1944	ATP diphosphatase activity
H8529_RS14590	COG2116	formate transmembrane transporter activity
H8529_RS14595	COG1882	Formate acetyltransferase
H8529_RS14600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H8529_RS14605	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8529_RS14610	COG0583	DNA-binding transcription factor activity
H8529_RS14615	COG0531	amino acid
H8529_RS14625	COG1335	isochorismatase
H8529_RS14630	COG3302	dmso reductase anchor subunit
H8529_RS14635	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS14640	COG0243	molybdopterin cofactor binding
H8529_RS14650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8529_RS14665	COG1522	sequence-specific DNA binding
H8529_RS14670	COG0492	ferredoxin-NADP+ reductase activity
H8529_RS14675	COG4988	ABC transporter
H8529_RS14680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8529_RS14700	COG0542	response to heat
H8529_RS14710	COG1278	Cold shock
H8529_RS14715	COG0577	efflux transmembrane transporter activity
H8529_RS14715	COG1136	(ABC) transporter
H8529_RS14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS14725	COG2990	Protein conserved in bacteria
H8529_RS14730	COG3593	DNA synthesis involved in DNA repair
H8529_RS14740	COG2431	L-lysine efflux transmembrane transporter activity
H8529_RS14750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8529_RS14755	COG0028	Belongs to the TPP enzyme family
H8529_RS14760	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H8529_RS14765	COG0702	epimerase
H8529_RS14770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8529_RS14775	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8529_RS14790	COG1126	abc transporter atp-binding protein
H8529_RS14795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS14800	COG4215	(ABC) transporter
H8529_RS14805	COG4160	amino acid transport
H8529_RS14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS14825	COG1177	transmembrane transport
H8529_RS14830	COG1176	ABC-type spermidine putrescine transport system, permease component I
H8529_RS14835	COG3842	ATPase activity
H8529_RS14840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H8529_RS14855	COG0778	Nitroreductase
H8529_RS14865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8529_RS14880	COG3226	Transcriptional regulator
H8529_RS14885	COG0738	Major facilitator superfamily
H8529_RS14890	COG0561	phosphatase activity
H8529_RS14900	COG2814	Major facilitator Superfamily
H8529_RS14905	COG0671	phosphoesterase, PA-phosphatase related
H8529_RS14910	COG1349	DNA-binding transcription factor activity
H8529_RS14915	COG1686	Belongs to the peptidase S11 family
H8529_RS14920	COG0625	glutathione transferase activity
H8529_RS14925	COG2133	pyrroloquinoline quinone binding
H8529_RS14940	COG2199	diguanylate cyclase activity
H8529_RS14945	COG2200	EAL domain
H8529_RS14970	COG1446	asparaginase
H8529_RS14975	COG0303	'Molybdopterin
H8529_RS14980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8529_RS14985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8529_RS14990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H8529_RS14995	COG1882	Formate acetyltransferase
H8529_RS15000	COG0561	phosphatase activity
H8529_RS15010	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS15015	COG0488	(ABC) transporter
H8529_RS15020	COG1376	ErfK ybiS ycfS ynhG family protein
H8529_RS15025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8529_RS15030	COG1321	iron dependent repressor
H8529_RS15040	COG2194	sulfuric ester hydrolase activity
H8529_RS15045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H8529_RS15055	COG5006	permease, DMT superfamily
H8529_RS15065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS15070	COG0765	amino acid transport
H8529_RS15075	COG1126	abc transporter atp-binding protein
H8529_RS15080	COG0668	transmembrane transport
H8529_RS15095	COG4774	siderophore transport
H8529_RS15105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8529_RS15115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H8529_RS15120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8529_RS15125	COG1199	ATP-dependent helicase activity
H8529_RS15130	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H8529_RS15135	COG0513	Belongs to the DEAD box helicase family
H8529_RS15140	COG1309	transcriptional regulator
H8529_RS15150	COG1131	(ABC) transporter
H8529_RS15155	COG0842	Transport permease protein
H8529_RS15160	COG0842	Transport permease protein
H8529_RS15170	COG3568	Endonuclease Exonuclease Phosphatase
H8529_RS15175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8529_RS15180	COG0392	lysyltransferase activity
H8529_RS15185	COG0670	Belongs to the BI1 family
H8529_RS15195	COG0670	Belongs to the BI1 family
H8529_RS15200	COG0314	molybdopterin synthase activity
H8529_RS15205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8529_RS15215	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8529_RS15225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8529_RS15235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H8529_RS15240	COG2226	methyltransferase
H8529_RS15255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8529_RS15260	COG1881	PFAM PEBP family protein
H8529_RS15265	COG4677	pectinesterase activity
H8529_RS15270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H8529_RS15275	COG0471	metal ion transport
H8529_RS15280	COG2828	Protein conserved in bacteria
H8529_RS15285	COG0583	DNA-binding transcription factor activity
H8529_RS15295	COG0561	phosphatase activity
H8529_RS15305	COG4149	molybdate abc transporter
H8529_RS15310	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8529_RS15320	COG3585	molybdate ion transport
H8529_RS15320	COG2005	Transcriptional regulator
H8529_RS15325	COG1119	ATPase activity
H8529_RS15330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8529_RS15335	COG1085	galactose-1-phosphate uridylyltransferase
H8529_RS15345	COG2017	converts alpha-aldose to the beta-anomer
H8529_RS15355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H8529_RS15365	COG1230	cation diffusion facilitator family transporter
H8529_RS15370	COG3201	nicotinamide mononucleotide transporter
H8529_RS15415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H8529_RS15420	COG2885	chlorophyll binding
H8529_RS15430	COG3064	Membrane
H8529_RS15435	COG0848	biopolymer transport protein
H8529_RS15440	COG0811	peptide transport
H8529_RS15445	COG0824	Thioesterase
H8529_RS15450	COG3790	cyd operon protein YbgE
H8529_RS15455	COG4890	Cyd operon protein YbgT
H8529_RS15460	COG1294	oxidase, subunit
H8529_RS15465	COG1271	oxidase subunit
H8529_RS15470	COG0383	alpha-mannosidase activity
H8529_RS15475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS15475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS15475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS15480	COG2188	Transcriptional regulator
H8529_RS15485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8529_RS15495	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8529_RS15500	COG0567	Dehydrogenase, E1 component
H8529_RS15505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8529_RS15510	COG1053	succinate dehydrogenase
H8529_RS15515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H8529_RS15520	COG2009	succinate dehydrogenase
H8529_RS15530	COG0372	Belongs to the citrate synthase family
H8529_RS15535	COG3539	Fimbrial protein
H8529_RS15540	COG3188	usher protein
H8529_RS15545	COG3121	Chaperone
H8529_RS15550	COG3539	Fimbrial protein
H8529_RS15555	COG3180	Ammonia monooxygenase
H8529_RS15570	COG1984	allophanate hydrolase subunit 2
H8529_RS15575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H8529_RS15580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H8529_RS15590	COG0415	Belongs to the DNA photolyase family
H8529_RS15595	COG3272	Protein of unknown function (DUF1722)
H8529_RS15615	COG3209	COG3209 Rhs family protein
H8529_RS15630	COG3209	COG3209 Rhs family protein
H8529_RS15660	COG2205	protein histidine kinase activity
H8529_RS15665	COG0745	RESPONSE REGULATOR receiver
H8529_RS15675	COG1982	Orn Lys Arg decarboxylase major
H8529_RS15680	COG0531	amino acid
H8529_RS15685	COG0033	Phosphoglucomutase
H8529_RS15690	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H8529_RS15695	COG0596	Alpha beta hydrolase
H8529_RS15705	COG0716	FMN binding
H8529_RS15715	COG0735	belongs to the Fur family
H8529_RS15735	COG1263	PTS System
H8529_RS15735	COG2190	(PTS) system
H8529_RS15735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS15745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8529_RS15750	COG1846	Transcriptional regulator
H8529_RS15750	COG1940	carbohydrate kinase activity
H8529_RS15755	COG0647	UMP catabolic process
H8529_RS15760	COG0367	asparagine synthase
H8529_RS15795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8529_RS15805	COG1702	phosphate starvation-inducible protein PhoH
H8529_RS15815	COG4535	Mg2 and Co2 transporter CorC
H8529_RS15820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8529_RS15830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8529_RS15835	COG0765	amino acid transport
H8529_RS15840	COG0765	amino acid transport
H8529_RS15845	COG1126	abc transporter atp-binding protein
H8529_RS15855	COG0443	Heat shock 70 kDa protein
H8529_RS15860	COG2214	Heat shock protein DnaJ domain protein
H8529_RS15870	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H8529_RS15875	COG2214	Heat shock protein DnaJ domain protein
H8529_RS15885	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H8529_RS15890	COG2888	peptidyl-tyrosine sulfation
H8529_RS15905	COG1466	dna polymerase III delta subunit
H8529_RS15915	COG0406	alpha-ribazole phosphatase activity
H8529_RS15920	COG0799	negative regulation of ribosome biogenesis
H8529_RS15930	COG0768	penicillin binding
H8529_RS15935	COG0772	Belongs to the SEDS family
H8529_RS15940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8529_RS15945	COG1686	Belongs to the peptidase S11 family
H8529_RS15960	COG0583	DNA-binding transcription factor activity
H8529_RS15970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8529_RS15975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8529_RS15995	COG3069	C4-dicarboxylate transmembrane transporter activity
H8529_RS16000	COG4565	transcriptional regulatory protein
H8529_RS16005	COG3290	protein histidine kinase activity
H8529_RS16010	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H8529_RS16020	COG2301	Belongs to the HpcH HpaI aldolase family
H8529_RS16025	COG3051	citrate lyase alpha subunit
H8529_RS16040	COG0471	metal ion transport
H8529_RS16045	COG3719	Belongs to the RNase T2 family
H8529_RS16050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8529_RS16055	COG1063	alcohol dehydrogenase
H8529_RS16060	COG0589	response to stress
H8529_RS16065	COG3634	alkyl hydroperoxide reductase activity
H8529_RS16070	COG0450	alkyl hydroperoxide reductase
H8529_RS16075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8529_RS16080	COG0583	DNA-binding transcription factor activity
H8529_RS16085	COG3969	phosphoadenosine phosphosulfate
H8529_RS16090	COG1475	DNA binding
H8529_RS16095	COG0436	Aminotransferase
H8529_RS16100	COG0371	Dehydrogenase
H8529_RS16105	COG2879	small protein
H8529_RS16110	COG1966	Carbon starvation protein
H8529_RS16115	COG2050	protein possibly involved in aromatic compounds catabolism
H8529_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS16125	COG3433	isochorismatase activity
H8529_RS16125	COG1535	isochorismatase
H8529_RS16130	COG1021	2,3-dihydroxybenzoate-AMP ligase
H8529_RS16135	COG1169	isochorismate synthase
H8529_RS16140	COG4592	Periplasmic binding protein
H8529_RS16150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8529_RS16155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8529_RS16160	COG1120	ATPase activity
H8529_RS16165	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H8529_RS16170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8529_RS16170	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H8529_RS16175	COG3251	PFAM MbtH domain protein
H8529_RS16180	COG2382	esterase
H8529_RS16185	COG4771	TonB-dependent receptor
H8529_RS16190	COG2977	Belongs to the P-Pant transferase superfamily
H8529_RS16215	COG2315	Protein conserved in bacteria
H8529_RS16220	COG0778	Nitroreductase
H8529_RS16225	COG0668	transmembrane transport
H8529_RS16230	COG1113	amino acid transport
H8529_RS16235	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8529_RS16240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS16245	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS16250	COG1538	Outer membrane efflux protein
H8529_RS16255	COG0745	RESPONSE REGULATOR receiver
H8529_RS16260	COG5002	protein histidine kinase activity
H8529_RS16275	COG4104	PAAR repeat-containing protein
H8529_RS16275	COG3209	COG3209 Rhs family protein
H8529_RS16290	COG5433	transposase activity
H8529_RS16295	COG1215	transferase activity, transferring glycosyl groups
H8529_RS16300	COG4783	chaperone-mediated protein folding
H8529_RS16310	COG2207	Transcriptional regulator
H8529_RS16315	COG4571	Outer membrane protease
H8529_RS16330	COG0500	methyltransferase
H8529_RS16335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8529_RS16340	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8529_RS16375	COG1196	nuclear chromosome segregation
H8529_RS16425	COG1030	water channel activity
H8529_RS16440	COG4220	transposase activity
H8529_RS16535	COG4220	transposase activity
H8529_RS16555	COG3772	lysozyme
H8529_RS16580	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H8529_RS16615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8529_RS16625	COG2076	Multidrug Resistance protein
H8529_RS16710	COG0582	viral genome integration into host DNA
H8529_RS16720	COG2197	response regulator
H8529_RS16725	COG3539	Fimbrial protein
H8529_RS16730	COG3539	Fimbrial protein
H8529_RS16735	COG3188	usher protein
H8529_RS16740	COG3121	Chaperone
H8529_RS16745	COG3539	Fimbrial protein
H8529_RS16755	COG2501	S4 domain
H8529_RS16760	COG1988	membrane-bound metal-dependent
H8529_RS16770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8529_RS16780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8529_RS16785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8529_RS16790	COG0549	Belongs to the carbamate kinase family
H8529_RS16800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8529_RS16805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8529_RS16810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H8529_RS16815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8529_RS16820	COG3257	ureidoglycine aminohydrolase activity
H8529_RS16825	COG1929	Belongs to the glycerate kinase type-1 family
H8529_RS16830	COG2233	PERMEase
H8529_RS16840	COG1953	Uracil, thiamine, allantoin
H8529_RS16845	COG2084	Dehydrogenase
H8529_RS16850	COG3622	Belongs to the hyi family
H8529_RS16855	COG3960	tartronate-semialdehyde synthase activity
H8529_RS16860	COG1414	Transcriptional regulator
H8529_RS16870	COG0583	DNA-binding transcription factor activity
H8529_RS16890	COG3209	COG3209 Rhs family protein
H8529_RS16895	COG3209	COG3209 Rhs family protein
H8529_RS16905	COG3209	COG3209 Rhs family protein
H8529_RS16910	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H8529_RS16915	COG4181	ATPase activity
H8529_RS16920	COG2755	lipolytic protein G-D-S-L family
H8529_RS16925	COG0300	oxidoreductase activity
H8529_RS16930	COG3118	belongs to the thioredoxin family
H8529_RS16935	COG0390	transport system, permease component
H8529_RS16940	COG4619	ABC transporter
H8529_RS16945	COG0330	HflC and HflK could
H8529_RS16950	COG1585	Membrane protein implicated in regulation of membrane protease activity
H8529_RS16955	COG0789	Transcriptional regulator
H8529_RS16960	COG0531	amino acid
H8529_RS16965	COG2066	Belongs to the glutaminase family
H8529_RS16970	COG2217	Heavy metal translocating P-type atpase
H8529_RS16975	COG3093	addiction module antidote protein HigA
H8529_RS16980	COG3735	TraB family
H8529_RS16985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8529_RS16990	COG0737	Belongs to the 5'-nucleotidase family
H8529_RS16995	COG2223	nitrite transmembrane transporter activity
H8529_RS17000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8529_RS17000	COG4651	solute:proton antiporter activity
H8529_RS17005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS17040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8529_RS17050	COG2832	Protein of unknown function (DUF454)
H8529_RS17055	COG3923	Primosomal replication protein n
H8529_RS17065	COG3264	Mechanosensitive ion channel
H8529_RS17065	COG1196	nuclear chromosome segregation
H8529_RS17070	COG1309	transcriptional regulator
H8529_RS17075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8529_RS17080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8529_RS17095	COG0110	maltose O-acetyltransferase activity
H8529_RS17105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8529_RS17110	COG5507	3-demethylubiquinone-9 3-methyltransferase
H8529_RS17120	COG3695	enzyme binding
H8529_RS17125	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H8529_RS17130	COG1946	Acyl-CoA thioesterase
H8529_RS17135	COG0004	ammonium transporteR
H8529_RS17140	COG0347	Belongs to the P(II) protein family
H8529_RS17145	COG1132	(ABC) transporter
H8529_RS17150	COG1132	(ABC) transporter
H8529_RS17155	COG1522	sequence-specific DNA binding
H8529_RS17165	COG4533	DNA binding
H8529_RS17175	COG0824	Thioesterase
H8529_RS17180	COG1555	photosystem II stabilization
H8529_RS17185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8529_RS17190	COG0776	regulation of translation
H8529_RS17195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H8529_RS17215	COG0271	Belongs to the BolA IbaG family
H8529_RS17220	COG3056	Lipoprotein
H8529_RS17225	COG2223	nitrite transmembrane transporter activity
H8529_RS17230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8529_RS17235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8529_RS17240	COG1845	cytochrome c oxidase, subunit III
H8529_RS17245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8529_RS17255	COG2814	Major facilitator Superfamily
H8529_RS17265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8529_RS17270	COG0693	protein deglycase activity
H8529_RS17285	COG0142	geranyltranstransferase activity
H8529_RS17295	COG0667	Aldo Keto reductase
H8529_RS17300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H8529_RS17305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8529_RS17320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8529_RS17320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8529_RS17330	COG4238	major outer membrane lipoprotein
H8529_RS17335	COG3248	Nucleoside-binding outer membrane protein
H8529_RS17340	COG1403	HNH endonuclease
H8529_RS17345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8529_RS17350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8529_RS17355	COG1862	Preprotein translocase
H8529_RS17375	COG0366	Alpha amylase catalytic
H8529_RS17380	COG1113	amino acid transport
H8529_RS17385	COG1114	Component of the transport system for branched-chain amino acids
H8529_RS17390	COG5002	protein histidine kinase activity
H8529_RS17395	COG0745	RESPONSE REGULATOR receiver
H8529_RS17400	COG0420	3'-5' exonuclease activity
H8529_RS17405	COG0419	ATPase involved in DNA repair
H8529_RS17410	COG2814	Major facilitator Superfamily
H8529_RS17440	COG4126	flavin adenine dinucleotide binding
H8529_RS17460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8529_RS17465	COG3706	GGDEF domain
H8529_RS17475	COG1785	Belongs to the alkaline phosphatase family
H8529_RS17490	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8529_RS17510	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H8529_RS17515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8529_RS17520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8529_RS17525	COG3468	outer membrane autotransporter barrel domain protein
H8529_RS17530	COG0113	porphobilinogen synthase activity
H8529_RS17535	COG2175	clavaminate synthase activity
H8529_RS17540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8529_RS17550	COG4521	taurine ABC transporter
H8529_RS17555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8529_RS17560	COG1215	transferase activity, transferring glycosyl groups
H8529_RS17590	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS17595	COG3122	Protein conserved in bacteria
H8529_RS17600	COG2814	Major facilitator Superfamily
H8529_RS17635	COG1414	Transcriptional regulator
H8529_RS17640	COG1609	Transcriptional regulator
H8529_RS17650	COG2223	nitrite transmembrane transporter activity
H8529_RS17655	COG2807	transmembrane transport
H8529_RS17665	COG0288	reversible hydration of carbon dioxide
H8529_RS17675	COG0402	S-adenosylhomocysteine deaminase activity
H8529_RS17680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H8529_RS17685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8529_RS17690	COG2079	MmgE PrpD family protein
H8529_RS17695	COG0372	Belongs to the citrate synthase family
H8529_RS17700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H8529_RS17705	COG3829	transcription factor binding
H8529_RS17715	COG1280	lysine exporter protein (LysE YggA)
H8529_RS17730	COG1064	alcohol dehydrogenase
H8529_RS17740	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8529_RS17745	COG1129	ABC transporter
H8529_RS17750	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS17760	COG0402	S-adenosylhomocysteine deaminase activity
H8529_RS17765	COG0549	Belongs to the carbamate kinase family
H8529_RS17770	COG1304	FMN binding
H8529_RS17775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8529_RS17785	COG0666	response to abiotic stimulus
H8529_RS17795	COG0583	DNA-binding transcription factor activity
H8529_RS17800	COG2200	EAL domain
H8529_RS17800	COG2771	luxR family
H8529_RS17810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8529_RS17835	COG0582	viral genome integration into host DNA
H8529_RS17840	COG2200	EAL domain
H8529_RS17840	COG2771	luxR family
H8529_RS17855	COG3468	outer membrane autotransporter barrel domain protein
H8529_RS17865	COG1556	Lactate utilization protein
H8529_RS17870	COG1139	Iron-sulfur cluster binding protein
H8529_RS17875	COG0247	lactate metabolic process
H8529_RS17880	COG2207	Transcriptional regulator
H8529_RS17885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8529_RS17895	COG3059	membrane
H8529_RS17900	COG0656	L-ascorbic acid biosynthetic process
H8529_RS17905	COG3708	Transcriptional regulator
H8529_RS17905	COG2207	Transcriptional regulator
H8529_RS17910	COG1388	LysM domain
H8529_RS17950	COG3188	usher protein
H8529_RS17960	COG3121	Chaperone
H8529_RS17965	COG0727	PFAM Uncharacterised protein family (UPF0153)
H8529_RS17970	COG3477	response to acidic pH
H8529_RS17975	COG2080	2 iron, 2 sulfur cluster binding
H8529_RS17980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8529_RS17985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8529_RS17990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8529_RS17995	COG0583	DNA-binding transcription factor activity
H8529_RS18005	COG2207	Transcriptional regulator
H8529_RS18015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H8529_RS18020	COG5301	cellulose 1,4-beta-cellobiosidase activity
H8529_RS18055	COG2963	transposase activity
H8529_RS18060	COG2801	Transposase and inactivated derivatives
H8529_RS18110	COG0740	serine-type endopeptidase activity
H8529_RS18145	COG3179	chitinase
H8529_RS18170	COG1403	HNH endonuclease
H8529_RS18180	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H8529_RS18190	COG4725	Belongs to the MT-A70-like family
H8529_RS18200	COG1846	Transcriptional regulator
H8529_RS18245	COG5532	Uncharacterized conserved protein (DUF2303)
H8529_RS18250	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H8529_RS18265	COG0582	viral genome integration into host DNA
H8529_RS18285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8529_RS18305	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8529_RS18310	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H8529_RS18315	COG1690	Belongs to the RtcB family
H8529_RS18320	COG0454	-acetyltransferase
H8529_RS18350	COG0791	NLP P60 protein
H8529_RS18355	COG3077	Addiction module antitoxin, RelB DinJ family
H8529_RS18360	COG3041	Addiction module toxin RelE StbE family
H8529_RS18365	COG3034	peptidoglycan biosynthetic process
H8529_RS18370	COG0121	glutamine amidotransferase
H8529_RS18380	COG1960	acyl-CoA dehydrogenase activity
H8529_RS18390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8529_RS18395	COG5433	transposase activity
H8529_RS18410	COG3209	COG3209 Rhs family protein
H8529_RS18500	COG3157	Type VI secretion system effector, Hcp
H8529_RS18505	COG4104	PAAR repeat-containing protein
H8529_RS18525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8529_RS18535	COG2226	methyltransferase
H8529_RS18545	COG0741	lytic transglycosylase activity
H8529_RS18545	COG1388	LysM domain
H8529_RS18550	COG2226	methyltransferase
H8529_RS18560	COG0583	DNA-binding transcription factor activity
H8529_RS18565	COG0656	L-ascorbic acid biosynthetic process
H8529_RS18600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H8529_RS18605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8529_RS18610	COG2011	ABC-type metal ion transport system permease component
H8529_RS18615	COG1464	Belongs to the NlpA lipoprotein family
H8529_RS18625	COG1720	tRNA m6t6A37 methyltransferase activity
H8529_RS18640	COG3015	lipoprotein NlpE involved in copper resistance
H8529_RS18645	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H8529_RS18650	COG4681	YaeQ
H8529_RS18660	COG4568	rho-dependent transcription termination
H8529_RS18670	COG0346	lactoylglutathione lyase activity
H8529_RS18675	COG1982	Orn Lys Arg decarboxylase major
H8529_RS18685	COG0587	DNA-directed DNA polymerase activity
H8529_RS18710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H8529_RS18715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H8529_RS18725	COG0750	zinc metalloprotease
H8529_RS18730	COG0575	Belongs to the CDS family
H8529_RS18735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8529_RS18740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8529_RS18765	COG0024	Methionine aminopeptidase
H8529_RS18785	COG3835	regulator
H8529_RS18790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8529_RS18805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8529_RS18810	COG2860	membrane
H8529_RS18835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8529_RS18840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8529_RS18845	COG1120	ATPase activity
H8529_RS18850	COG4774	siderophore transport
H8529_RS18855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8529_RS18860	COG1643	Atp-dependent helicase
H8529_RS18865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H8529_RS18875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8529_RS18885	COG0617	tRNA 3'-terminal CCA addition
H8529_RS18890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8529_RS18895	COG3539	Fimbrial protein
H8529_RS18900	COG3121	Chaperone
H8529_RS18905	COG3188	usher protein
H8529_RS18910	COG3539	Fimbrial protein
H8529_RS18915	COG3539	Fimbrial protein
H8529_RS18920	COG3539	Fimbrial protein
H8529_RS18925	COG3539	Fimbrial protein
H8529_RS18940	COG5464	transposase or invertase
H8529_RS18950	COG0726	polysaccharide deacetylase
H8529_RS18955	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS18960	COG0842	Transport permease protein
H8529_RS18965	COG1131	(ABC) transporter
H8529_RS18970	COG0288	reversible hydration of carbon dioxide
H8529_RS18975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8529_RS18980	COG4993	Dehydrogenase
H8529_RS18985	COG2132	Multicopper oxidase
H8529_RS19010	COG1049	propionate catabolic process, 2-methylcitrate cycle
H8529_RS19015	COG3064	Membrane
H8529_RS19020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8529_RS19025	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8529_RS19030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H8529_RS19035	COG2186	Transcriptional regulator
H8529_RS19040	COG1113	amino acid transport
H8529_RS19045	COG3725	Membrane protein required for beta-lactamase induction
H8529_RS19050	COG3023	N-Acetylmuramoyl-L-alanine amidase
H8529_RS19055	COG0157	Belongs to the NadC ModD family
H8529_RS19060	COG4969	Belongs to the N-Me-Phe pilin family
H8529_RS19065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8529_RS19070	COG1459	type II secretion system
H8529_RS19085	COG0237	dephospho-CoA kinase activity
H8529_RS19100	COG0494	nUDIX hydrolase
H8529_RS19120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8529_RS19125	COG0849	cell division
H8529_RS19130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8529_RS19135	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8529_RS19150	COG0772	Belongs to the SEDS family
H8529_RS19165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8529_RS19170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8529_RS19175	COG0768	penicillin binding
H8529_RS19180	COG3116	cell division
H8529_RS19195	COG1609	Transcriptional regulator
H8529_RS19205	COG0440	acetolactate synthase activity
H8529_RS19210	COG0028	Belongs to the TPP enzyme family
H8529_RS19220	COG0583	DNA-binding transcription factor activity
H8529_RS19235	COG0473	3-isopropylmalate dehydrogenase activity
H8529_RS19250	COG2814	Major facilitator Superfamily
H8529_RS19265	COG4143	(ABC) transporter
H8529_RS19270	COG1178	ABC-type Fe3 transport system permease component
H8529_RS19280	COG0586	Pfam SNARE associated Golgi protein
H8529_RS19285	COG4977	sequence-specific DNA binding
H8529_RS19300	COG0235	Class ii aldolase
H8529_RS19305	COG0417	DNA replication proofreading
H8529_RS19315	COG0564	pseudouridine synthase activity
H8529_RS19320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H8529_RS19325	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8529_RS19330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8529_RS19355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8529_RS19370	COG2271	Major facilitator Superfamily
H8529_RS19375	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H8529_RS19380	COG0644	oxidoreductase
H8529_RS19405	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS19435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8529_RS19440	COG0505	Belongs to the CarA family
H8529_RS19460	COG1047	Peptidyl-prolyl cis-trans
H8529_RS19475	COG0196	riboflavin kinase activity
H8529_RS19505	COG0583	DNA-binding transcription factor activity
H8529_RS19535	COG4735	regulation of single-species biofilm formation
H8529_RS19540	COG1584	GPR1 FUN34 yaaH family protein
H8529_RS19545	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8529_RS19550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8529_RS19555	COG1115	amino acid carrier protein
H8529_RS19565	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS19575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8529_RS19585	COG0527	aspartate kinase activity
H8529_RS19585	COG0460	homoserine dehydrogenase
H8529_RS19595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H8529_RS19605	COG0745	RESPONSE REGULATOR receiver
H8529_RS19610	COG4452	Inner membrane protein CreD
H8529_RS19615	COG2205	protein histidine kinase activity
H8529_RS19620	COG0745	RESPONSE REGULATOR receiver
H8529_RS19625	COG3045	CreA protein
H8529_RS19630	COG2207	Transcriptional regulator
H8529_RS19630	COG3708	Transcriptional regulator
H8529_RS19650	COG0741	lytic transglycosylase activity
H8529_RS19655	COG0488	(ABC) transporter
H8529_RS19660	COG3172	ATPase kinase involved in NAD metabolism
H8529_RS19660	COG1056	cytidyltransferase-related domain
H8529_RS19665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8529_RS19670	COG0560	Phosphoserine phosphatase
H8529_RS19675	COG3726	membrane protein affecting hemolysin expression
H8529_RS19710	COG1328	CTP reductase activity
H8529_RS19715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H8529_RS19720	COG0084	hydrolase, TatD family'
H8529_RS19725	COG4667	esterase of the alpha-beta hydrolase superfamily
H8529_RS19735	COG2823	Periplasmic or secreted lipoprotein
H8529_RS19745	COG1011	Hydrolase
H8529_RS19750	COG0456	acetyltransferase
H8529_RS19755	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
H8529_RS19785	COG4114	ferric iron reductase
H8529_RS19790	COG2197	response regulator
H8529_RS19795	COG2197	response regulator
H8529_RS19800	COG2966	Psort location CytoplasmicMembrane, score
H8529_RS19815	COG1484	DNA-dependent DNA replication
H8529_RS19830	COG1063	alcohol dehydrogenase
H8529_RS19835	COG1802	Transcriptional regulator
H8529_RS19840	COG2271	Major facilitator Superfamily
H8529_RS19845	COG0840	transmembrane signaling receptor activity
H8529_RS19850	COG1846	Transcriptional regulator
H8529_RS19855	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8529_RS19860	COG1012	belongs to the aldehyde dehydrogenase family
H8529_RS19865	COG3384	dioxygenase
H8529_RS19875	COG3971	2-oxopent-4-enoate hydratase activity
H8529_RS19895	COG2368	4-hydroxyphenylacetate
H8529_RS19900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8529_RS19905	COG1966	Carbon starvation protein
H8529_RS19910	COG2879	small protein
H8529_RS19915	COG0523	cobalamin synthesis protein
H8529_RS19925	COG5457	Domain of unknown function (DUF1127)
H8529_RS19930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8529_RS19940	COG2814	Major facilitator Superfamily
H8529_RS19945	COG2733	membrane
H8529_RS19950	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H8529_RS19955	COG1924	4 iron, 4 sulfur cluster binding
H8529_RS19970	COG0477	Major facilitator Superfamily
H8529_RS19980	COG3366	ferrous iron transmembrane transporter activity
H8529_RS19985	COG0700	Nucleoside recognition
H8529_RS19990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8529_RS19995	COG0583	DNA-binding transcription factor activity
H8529_RS20015	COG2186	Transcriptional regulator
H8529_RS20020	COG0246	Mannitol dehydrogenase
H8529_RS20030	COG2610	gluconate transmembrane transporter activity
H8529_RS20035	COG3539	Fimbrial protein
H8529_RS20040	COG3539	Fimbrial protein
H8529_RS20045	COG3539	Fimbrial protein
H8529_RS20050	COG3188	usher protein
H8529_RS20055	COG3121	Chaperone
H8529_RS20060	COG3539	Fimbrial protein
H8529_RS20070	COG4974	Belongs to the 'phage' integrase family
H8529_RS20075	COG0582	viral genome integration into host DNA
H8529_RS20080	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H8529_RS20085	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
H8529_RS20105	COG1401	restriction endodeoxyribonuclease activity
H8529_RS20160	COG0515	serine threonine protein kinase
H8529_RS20160	COG2815	serine threonine protein kinase
H8529_RS20165	COG0582	viral genome integration into host DNA
H8529_RS20175	COG1064	alcohol dehydrogenase
H8529_RS20180	COG0433	COG0433 Predicted ATPase
H8529_RS20185	COG0795	lipopolysaccharide-transporting ATPase activity
H8529_RS20190	COG0795	lipopolysaccharide-transporting ATPase activity
H8529_RS20200	COG2927	DNA polymerase III (CHI subunit)
H8529_RS20205	COG0525	valine-tRNA ligase activity
H8529_RS20210	COG4269	membrane
H8529_RS20215	COG0456	acetyltransferase
H8529_RS20220	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H8529_RS20245	COG2731	YhcH YjgK YiaL family protein
H8529_RS20250	COG1309	transcriptional regulator
H8529_RS20255	COG1028	Short-chain dehydrogenase reductase Sdr
H8529_RS20260	COG0251	oxidation-reduction process
H8529_RS20280	COG0251	oxidation-reduction process
H8529_RS20285	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS20290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8529_RS20300	COG1609	Transcriptional regulator
H8529_RS20305	COG1263	PTS System
H8529_RS20305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS20310	COG0366	Alpha amylase catalytic
H8529_RS20315	COG1328	CTP reductase activity
H8529_RS20320	COG0602	queuosine metabolic process
H8529_RS20325	COG3783	Cytochrome b(562)
H8529_RS20330	COG0312	modulator of DNA gyrase
H8529_RS20340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8529_RS20350	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8529_RS20355	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8529_RS20360	COG1129	ABC transporter
H8529_RS20365	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS20370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H8529_RS20375	COG2105	PFAM AIG2 family protein
H8529_RS20380	COG2911	Protein conserved in bacteria
H8529_RS20385	COG0729	surface antigen
H8529_RS20395	COG1253	flavin adenine dinucleotide binding
H8529_RS20405	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H8529_RS20410	COG1218	3'(2'),5'-bisphosphate nucleotidase
H8529_RS20415	COG0737	Belongs to the 5'-nucleotidase family
H8529_RS20420	COG1733	regulation of RNA biosynthetic process
H8529_RS20425	COG0702	epimerase
H8529_RS20430	COG0697	spore germination
H8529_RS20440	COG1113	amino acid transport
H8529_RS20445	COG0545	Peptidyl-prolyl cis-trans isomerase
H8529_RS20450	COG3061	Opacity-associated protein A
H8529_RS20455	COG1309	transcriptional regulator
H8529_RS20470	COG1024	Enoyl-CoA hydratase
H8529_RS20475	COG4670	ketone body catabolic process
H8529_RS20480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8529_RS20485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H8529_RS20495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8529_RS20505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8529_RS20550	COG3037	sugar-specific permease SgaT UlaA
H8529_RS20565	COG1073	alpha beta
H8529_RS20570	COG3650	response to hydrogen peroxide
H8529_RS20580	COG1960	acyl-CoA dehydrogenase activity
H8529_RS20585	COG0754	glutathionylspermidine amidase activity
H8529_RS20590	COG5463	Belongs to the UPF0441 family
H8529_RS20595	COG3766	membrane
H8529_RS20605	COG1842	Phage shock protein A
H8529_RS20610	COG3789	protein conserved in bacteria
H8529_RS20615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8529_RS20620	COG0557	exoribonuclease II activity
H8529_RS20635	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H8529_RS20640	COG0330	HflC and HflK could
H8529_RS20645	COG0330	HflC and HflK could
H8529_RS20650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8529_RS20670	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8529_RS20675	COG0802	atpase or kinase
H8529_RS20680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8529_RS20680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H8529_RS20685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8529_RS20725	COG3264	Mechanosensitive ion channel
H8529_RS20725	COG1511	domain protein
H8529_RS20730	COG0531	amino acid
H8529_RS20740	COG1053	succinate dehydrogenase
H8529_RS20745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8529_RS20760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8529_RS20765	COG3040	lipid binding
H8529_RS20770	COG2076	Multidrug Resistance protein
H8529_RS20775	COG5510	response to toxic substance
H8529_RS20780	COG5510	response to toxic substance
H8529_RS20790	COG1509	lysine 2,3-aminomutase activity
H8529_RS20815	COG0531	amino acid
H8529_RS20820	COG3030	protein affecting phage T7 exclusion by the F plasmid
H8529_RS20825	COG1027	Aspartate ammonia-lyase
H8529_RS20830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H8529_RS20845	COG1309	transcriptional regulator
H8529_RS20855	COG3710	Transcriptional regulator
H8529_RS20860	COG0531	amino acid
H8529_RS20865	COG1982	Orn Lys Arg decarboxylase major
H8529_RS20870	COG3104	oligopeptide transport
H8529_RS20875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8529_RS20890	COG2388	GCN5-related N-acetyl-transferase
H8529_RS20895	COG3592	Divergent 4Fe-4S mono-cluster
H8529_RS20900	COG3290	protein histidine kinase activity
H8529_RS20905	COG4565	transcriptional regulatory protein
H8529_RS20910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H8529_RS20915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H8529_RS20915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H8529_RS20920	COG3647	Membrane
H8529_RS20925	COG2211	Major facilitator Superfamily
H8529_RS20930	COG1486	melibiose metabolic process
H8529_RS20935	COG2169	Transcriptional regulator
H8529_RS20940	COG1982	Orn Lys Arg decarboxylase major
H8529_RS20945	COG2207	Transcriptional regulator
H8529_RS20950	COG0531	amino acid
H8529_RS20955	COG2194	sulfuric ester hydrolase activity
H8529_RS20960	COG0745	RESPONSE REGULATOR receiver
H8529_RS20965	COG0642	Histidine kinase
H8529_RS20975	COG0477	Major facilitator Superfamily
H8529_RS20990	COG2824	Alkylphosphonate utilization operon protein PhnA
H8529_RS20995	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H8529_RS21005	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H8529_RS21010	COG3639	organic phosphonate transmembrane transporter activity
H8529_RS21015	COG2188	Transcriptional regulator
H8529_RS21020	COG3624	Phosphonate C-P lyase system protein PhnG
H8529_RS21025	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
H8529_RS21030	COG3626	phosphonate metabolism
H8529_RS21035	COG3627	carbon phosphorus lyase activity
H8529_RS21040	COG4107	phosphonate C-P lyase system protein PhnK
H8529_RS21045	COG4778	phosphonate C-P lyase system protein PhnL
H8529_RS21050	COG3454	Phosphonate metabolism
H8529_RS21055	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H8529_RS21060	COG0456	acetyltransferase
H8529_RS21065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8529_RS21075	COG0698	ribose 5-phosphate isomerase
H8529_RS21080	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H8529_RS21090	COG1566	PFAM secretion protein HlyD family protein
H8529_RS21095	COG1289	transmembrane transporter activity
H8529_RS21110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H8529_RS21115	COG1301	dicarboxylic acid transport
H8529_RS21120	COG4235	cytochrome complex assembly
H8529_RS21125	COG3088	subunit of a heme lyase
H8529_RS21130	COG1138	Cytochrome C-type biogenesis protein
H8529_RS21135	COG3301	Polysulphide reductase, NrfD
H8529_RS21140	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS21145	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H8529_RS21155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8529_RS21160	COG3162	membrane
H8529_RS21170	COG1357	PFAM Pentapeptide repeats (8 copies)
H8529_RS21175	COG0025	NhaP-type Na H and K H
H8529_RS21180	COG2252	PERMEase
H8529_RS21185	COG0789	Transcriptional regulator
H8529_RS21190	COG2207	Transcriptional regulator
H8529_RS21195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H8529_RS21205	COG0629	single-stranded DNA binding
H8529_RS21210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8529_RS21215	COG2315	Protein conserved in bacteria
H8529_RS21220	COG0432	Pfam Uncharacterised protein family UPF0047
H8529_RS21225	COG3700	Belongs to the class B bacterial acid phosphatase family
H8529_RS21235	COG1448	Aminotransferase
H8529_RS21240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8529_RS21245	COG0305	Participates in initiation and elongation during chromosome replication
H8529_RS21250	COG0604	alcohol dehydrogenase
H8529_RS21260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8529_RS21270	COG0735	belongs to the Fur family
H8529_RS21275	COG3237	CsbD-like
H8529_RS21280	COG0534	Mate efflux family protein
H8529_RS21290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8529_RS21325	COG3842	ATPase activity
H8529_RS21330	COG2182	Extracellular solute-binding protein
H8529_RS21335	COG1175	transmembrane transport
H8529_RS21340	COG3833	ABC-type maltose transport systems, permease component
H8529_RS21345	COG0477	Major facilitator Superfamily
H8529_RS21345	COG2814	Major facilitator Superfamily
H8529_RS21360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8529_RS21385	COG0527	aspartate kinase activity
H8529_RS21390	COG0542	response to heat
H8529_RS21395	COG3541	Predicted nucleotidyltransferase
H8529_RS21420	COG1283	sodium-dependent phosphate transmembrane transporter activity
H8529_RS21425	COG1410	methionine synthase
H8529_RS21425	COG0646	methionine synthase
H8529_RS21430	COG1414	Transcriptional regulator
H8529_RS21445	COG2224	Isocitrate lyase
H8529_RS21450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8529_RS21460	COG0456	acetyltransferase
H8529_RS21490	COG0151	Belongs to the GarS family
H8529_RS21495	COG2204	response regulator
H8529_RS21500	COG4191	Histidine kinase
H8529_RS21505	COG3678	ATP-independent chaperone mediated protein folding
H8529_RS21520	COG3068	Protein conserved in bacteria
H8529_RS21555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8529_RS21560	COG2104	thiamine diphosphate biosynthetic process
H8529_RS21570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8529_RS21610	COG0250	Participates in transcription elongation, termination and antitermination
H8529_RS21615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8529_RS21650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H8529_RS21650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H8529_RS21700	COG1309	transcriptional regulator
H8529_RS21710	COG0583	DNA-binding transcription factor activity
H8529_RS21715	COG2271	Major facilitator Superfamily
H8529_RS21720	COG4948	Mandelate Racemase Muconate Lactonizing
H8529_RS21735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8529_RS21750	COG2194	sulfuric ester hydrolase activity
H8529_RS21755	COG2207	Transcriptional regulator
H8529_RS21760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS21765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H8529_RS21770	COG1882	Formate acetyltransferase
H8529_RS21775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS21780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS21785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8529_RS21785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS21785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS21790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8529_RS21795	COG0371	Dehydrogenase
H8529_RS21800	COG3738	Protein conserved in bacteria
H8529_RS21805	COG0697	spore germination
H8529_RS21815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8529_RS21820	COG0460	homoserine dehydrogenase
H8529_RS21820	COG0527	aspartate kinase activity
H8529_RS21825	COG0626	cystathionine gamma-synthase activity
H8529_RS21835	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H8529_RS21850	COG3209	COG3209 Rhs family protein
H8529_RS21860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8529_RS21865	COG1609	Transcriptional regulator
H8529_RS21870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8529_RS21885	COG1575	Belongs to the MenA family. Type 1 subfamily
H8529_RS21900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8529_RS21910	COG1494	fructose-1,6-bisphosphatase
H8529_RS21920	COG0589	response to stress
H8529_RS21925	COG3691	Protein conserved in bacteria
H8529_RS21930	COG3152	Membrane
H8529_RS21950	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H8529_RS21965	COG3678	ATP-independent chaperone mediated protein folding
H8529_RS21970	COG0745	RESPONSE REGULATOR receiver
H8529_RS21975	COG2205	protein histidine kinase activity
H8529_RS21980	COG3547	Transposase (IS116 IS110 IS902 family)
H8529_RS21985	COG2258	MOSC domain
H8529_RS21995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8529_RS22035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS22040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS22040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8529_RS22045	COG1363	Peptidase, m42
H8529_RS22050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8529_RS22050	COG3711	transcriptional antiterminator
H8529_RS22070	COG0437	4 iron, 4 sulfur cluster binding
H8529_RS22075	COG2864	formate dehydrogenase
H8529_RS22085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H8529_RS22090	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H8529_RS22100	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
H8529_RS22110	COG0456	acetyltransferase
H8529_RS22125	COG1011	Hydrolase
H8529_RS22135	COG0477	Major facilitator Superfamily
H8529_RS22145	COG1063	alcohol dehydrogenase
H8529_RS22150	COG3684	Belongs to the aldolase LacD family
H8529_RS22155	COG2084	Dehydrogenase
H8529_RS22160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS22165	COG1349	DNA-binding transcription factor activity
H8529_RS22170	COG2271	Major facilitator Superfamily
H8529_RS22175	COG1082	Xylose isomerase domain protein TIM barrel
H8529_RS22180	COG2188	Transcriptional regulator
H8529_RS22185	COG1217	gtp-binding protein TYPA
H8529_RS22190	COG0174	glutamine synthetase
H8529_RS22195	COG3852	Histidine kinase
H8529_RS22200	COG2204	response regulator
H8529_RS22210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8529_RS22225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8529_RS22225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8529_RS22230	COG0204	Acyl-transferase
H8529_RS22235	COG5339	Protein conserved in bacteria
H8529_RS22240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8529_RS22245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8529_RS22250	COG3084	Protein conserved in bacteria
H8529_RS22255	COG0746	molybdenum cofactor guanylyltransferase activity
H8529_RS22260	COG1763	Mo-molybdopterin cofactor biosynthetic process
H8529_RS22290	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H8529_RS22295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8529_RS22300	COG1739	Uncharacterized protein family UPF0029
H8529_RS22320	COG0543	2 iron, 2 sulfur cluster binding
H8529_RS22325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8529_RS22330	COG0250	Participates in transcription elongation, termination and antitermination
H8529_RS22340	COG0805	protein transport
H8529_RS22345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8529_RS22350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8529_RS22360	COG3165	ubiquinone biosynthetic process from chorismate
H8529_RS22370	COG1322	Protein conserved in bacteria
H8529_RS22375	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H8529_RS22380	COG0412	Dienelactone hydrolase
H8529_RS22390	COG0583	DNA-binding transcription factor activity
H8529_RS22395	COG0697	spore germination
H8529_RS22400	COG0561	phosphatase activity
H8529_RS22405	COG2267	carboxylic ester hydrolase activity
H8529_RS22410	COG1280	lysine exporter protein (LysE YggA)
H8529_RS22415	COG1280	lysine exporter protein (LysE YggA)
H8529_RS22420	COG0514	ATP-dependent DNA helicase (RecQ)
H8529_RS22425	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H8529_RS22430	COG2050	protein possibly involved in aromatic compounds catabolism
H8529_RS22435	COG2962	Rard protein
H8529_RS22460	COG0598	Magnesium transport protein CorA
H8529_RS22465	COG3698	Phosphodiester glycosidase
H8529_RS22470	COG0210	DNA helicase
H8529_RS22475	COG1011	Hydrolase
H8529_RS22485	COG3159	Protein conserved in bacteria
H8529_RS22495	COG5567	small periplasmic lipoprotein
H8529_RS22505	COG3072	Adenylate cyclase
H8529_RS22515	COG1587	Uroporphyrinogen-III synthase
H8529_RS22520	COG2959	enzyme of heme biosynthesis
H8529_RS22525	COG3071	HemY protein
H8529_RS22530	COG3119	arylsulfatase activity
H8529_RS22535	COG0641	radical SAM
H8529_RS22560	COG1113	amino acid transport
H8529_RS22580	COG2244	polysaccharide biosynthetic process
H8529_RS22585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8529_RS22590	COG0456	acetyltransferase
H8529_RS22595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8529_RS22600	COG1088	dTDP-glucose 4,6-dehydratase activity
H8529_RS22605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H8529_RS22610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8529_RS22615	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H8529_RS22620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8529_RS22625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8529_RS22635	COG3118	belongs to the thioredoxin family
H8529_RS22650	COG0210	DNA helicase
H8529_RS22655	COG3692	DNA binding
H8529_RS22660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8529_RS22670	COG0583	DNA-binding transcription factor activity
H8529_RS22675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8529_RS22685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8529_RS22690	COG3978	acetolactate synthase activity
H8529_RS22710	COG0606	chelatase, subunit chli
H8529_RS22715	COG3085	chromosome segregation
H8529_RS22755	COG2186	Transcriptional regulator
H8529_RS22760	COG0477	Major facilitator Superfamily
H8529_RS22765	COG1609	Transcriptional regulator
H8529_RS22770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8529_RS22775	COG1879	ABC-type sugar transport system periplasmic component
H8529_RS22780	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8529_RS22785	COG1129	ABC transporter
H8529_RS22815	COG1522	sequence-specific DNA binding
H8529_RS22820	COG0716	FMN binding
H8529_RS22835	COG3312	ion transport
H8529_RS22885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8529_RS22900	COG3188	usher protein
H8529_RS22910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8529_RS22915	COG0573	inorganic phosphate transmembrane transporter activity
H8529_RS22920	COG0581	inorganic phosphate transmembrane transporter activity
H8529_RS22925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8529_RS22930	COG0704	Plays a role in the regulation of phosphate uptake
H8529_RS22935	COG3711	transcriptional antiterminator
H8529_RS22940	COG1263	PTS System
H8529_RS22940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8529_RS22940	COG2190	(PTS) system
H8529_RS22945	COG2723	6-phospho-beta-galactosidase activity
H8529_RS22955	COG2382	esterase
H8529_RS22960	COG0363	glucosamine-6-phosphate deaminase activity
H8529_RS22965	COG3196	Protein conserved in bacteria
H8529_RS22975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8529_RS22980	COG2252	PERMEase
H8529_RS22985	COG0431	NADPH-dependent FMN reductase
H8529_RS22990	COG2091	lysine biosynthetic process via aminoadipic acid
H8529_RS23005	COG0814	amino acid
H8529_RS23120	COG3210	domain, Protein
H8529_RS23125	COG3210	domain, Protein
H8529_RS23145	COG3468	outer membrane autotransporter barrel domain protein
H8529_RS23145	COG3210	domain, Protein
H8529_RS23195	COG2197	response regulator
H8529_RS23215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8529_RS23225	COG1960	acyl-CoA dehydrogenase activity
H8529_RS23235	COG0121	glutamine amidotransferase
H8529_RS23240	COG3034	peptidoglycan biosynthetic process
H8529_RS23245	COG0791	NLP P60 protein
H8529_RS23260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8529_RS23265	COG0454	-acetyltransferase
H8529_RS23270	COG1690	Belongs to the RtcB family
H8529_RS23275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H8529_RS23280	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8529_RS23300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H8529_RS23340	COG4983	Phage plasmid primase, P4 family domain protein
H8529_RS23345	COG4983	Phage plasmid primase, P4 family domain protein
H8529_RS23365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8529_RS23365	COG0758	DNA mediated transformation
H8529_RS23395	COG2963	transposase activity
H8529_RS23400	COG2801	Transposase and inactivated derivatives
H8529_RS23410	COG3436	PFAM IS66 Orf2 family protein
H8529_RS23415	COG4372	Transposase