locus-tag	class	description
CRG85_RS00010	COG0592	DNA-directed DNA polymerase activity
CRG85_RS00020	COG0187	DNA topoisomerase II activity
CRG85_RS00025	COG3753	Protein conserved in bacteria
CRG85_RS00030	COG0561	phosphatase activity
CRG85_RS00040	COG2186	Transcriptional regulator
CRG85_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
CRG85_RS00050	COG0800	Aldolase
CRG85_RS00060	COG2271	Major facilitator Superfamily
CRG85_RS00065	COG0644	oxidoreductase
CRG85_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
CRG85_RS00075	COG5645	(Lipo)protein
CRG85_RS00095	COG2188	Transcriptional regulator
CRG85_RS00110	COG2207	Transcriptional regulator
CRG85_RS00115	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRG85_RS00120	COG3119	arylsulfatase activity
CRG85_RS00130	COG2149	membrane
CRG85_RS00140	COG0641	radical SAM
CRG85_RS00145	COG2814	Major facilitator Superfamily
CRG85_RS00160	COG0028	Belongs to the TPP enzyme family
CRG85_RS00165	COG0440	acetolactate synthase activity
CRG85_RS00170	COG2197	response regulator
CRG85_RS00175	COG3851	Histidine kinase
CRG85_RS00180	COG2271	Major facilitator Superfamily
CRG85_RS00185	COG2271	Major facilitator Superfamily
CRG85_RS00195	COG2252	PERMEase
CRG85_RS00215	COG1464	Belongs to the NlpA lipoprotein family
CRG85_RS00220	COG0697	spore germination
CRG85_RS00225	COG2814	Major facilitator Superfamily
CRG85_RS00235	COG0582	viral genome integration into host DNA
CRG85_RS00250	COG1501	Belongs to the glycosyl hydrolase 31 family
CRG85_RS00255	COG2982	Protein involved in outer membrane biogenesis
CRG85_RS00260	COG2233	PERMEase
CRG85_RS00265	COG0786	glutamate:sodium symporter activity
CRG85_RS00270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRG85_RS00275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRG85_RS00280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRG85_RS00290	COG0194	GDP metabolic process
CRG85_RS00300	COG2860	membrane
CRG85_RS00305	COG3645	SOS response
CRG85_RS00310	COG1561	YicC-like family, N-terminal region
CRG85_RS00335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CRG85_RS00365	COG1519	Transferase
CRG85_RS00370	COG0859	PFAM glycosyl transferase family 9
CRG85_RS00375	COG0438	transferase activity, transferring glycosyl groups
CRG85_RS00380	COG0515	serine threonine protein kinase
CRG85_RS00385	COG1442	glycosyl transferase family 8
CRG85_RS00390	COG0438	transferase activity, transferring glycosyl groups
CRG85_RS00395	COG1442	glycosyl transferase family 8
CRG85_RS00400	COG1442	glycosyl transferase family 8
CRG85_RS00405	COG3642	lipopolysaccharide core region biosynthetic process
CRG85_RS00425	COG0859	PFAM glycosyl transferase family 9
CRG85_RS00430	COG0859	PFAM glycosyl transferase family 9
CRG85_RS00440	COG0156	8-amino-7-oxononanoate synthase activity
CRG85_RS00450	COG1216	Glycosyl transferase, family 2
CRG85_RS00455	COG2861	carbohydrate metabolic process
CRG85_RS00460	COG4942	peptidase
CRG85_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRG85_RS00480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRG85_RS00495	COG1045	serine acetyltransferase
CRG85_RS00500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CRG85_RS00510	COG2186	Transcriptional regulator
CRG85_RS00515	COG1620	l-lactate permease
CRG85_RS00530	COG3722	fumarate hydratase activity
CRG85_RS00540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS00540	COG2213	PTS system mannitol-specific
CRG85_RS00550	COG1566	PFAM secretion protein HlyD family protein
CRG85_RS00570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CRG85_RS00575	COG3209	COG3209 Rhs family protein
CRG85_RS00580	COG0625	glutathione transferase activity
CRG85_RS00590	COG3276	selenocysteine insertion sequence binding
CRG85_RS00595	COG1454	alcohol dehydrogenase
CRG85_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS00615	COG1566	PFAM secretion protein HlyD family protein
CRG85_RS00620	COG0583	DNA-binding transcription factor activity
CRG85_RS00625	COG3713	MltA-interacting MipA family protein
CRG85_RS00635	COG0235	Class ii aldolase
CRG85_RS00640	COG3623	hexulose-6-phosphate isomerase
CRG85_RS00645	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CRG85_RS00650	COG1070	Carbohydrate kinase
CRG85_RS00655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CRG85_RS00660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CRG85_RS00665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CRG85_RS00670	COG2731	YhcH YjgK YiaL family protein
CRG85_RS00680	COG1414	Transcriptional regulator
CRG85_RS00685	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS00690	COG3977	Valine--pyruvate aminotransferase
CRG85_RS00695	COG0366	Alpha amylase catalytic
CRG85_RS00700	COG2992	FlgJ-related protein
CRG85_RS00705	COG1609	Transcriptional regulator
CRG85_RS00705	COG2207	Transcriptional regulator
CRG85_RS00710	COG4214	carbohydrate transport
CRG85_RS00715	COG1129	ABC transporter
CRG85_RS00720	COG4213	ABC transporter substrate-binding protein
CRG85_RS00730	COG1070	Carbohydrate kinase
CRG85_RS00735	COG4682	membrane
CRG85_RS00740	COG4682	membrane
CRG85_RS00745	COG3274	enterobacterial common antigen metabolic process
CRG85_RS00775	COG1278	Cold shock
CRG85_RS00780	COG2944	sequence-specific DNA binding
CRG85_RS00795	COG2885	chlorophyll binding
CRG85_RS00800	COG0243	molybdopterin cofactor binding
CRG85_RS00805	COG0456	acetyltransferase
CRG85_RS00810	COG2818	Glycosylase
CRG85_RS00815	COG5571	outer membrane autotransporter
CRG85_RS00820	COG2223	nitrite transmembrane transporter activity
CRG85_RS00825	COG2194	sulfuric ester hydrolase activity
CRG85_RS00840	COG0747	negative chemotaxis
CRG85_RS00850	COG0601	transmembrane transport
CRG85_RS00855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRG85_RS00860	COG0444	Belongs to the ABC transporter superfamily
CRG85_RS00865	COG4608	Belongs to the ABC transporter superfamily
CRG85_RS00870	COG0814	amino acid
CRG85_RS00900	COG2194	sulfuric ester hydrolase activity
CRG85_RS00925	COG1215	transferase activity, transferring glycosyl groups
CRG85_RS00930	COG1215	transferase activity, transferring glycosyl groups
CRG85_RS00935	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CRG85_RS00940	COG3118	belongs to the thioredoxin family
CRG85_RS00940	COG0457	Tetratricopeptide repeat
CRG85_RS00945	COG2199	diguanylate cyclase activity
CRG85_RS00945	COG2200	EAL domain
CRG85_RS00955	COG0612	Peptidase, M16
CRG85_RS00965	COG2200	EAL domain
CRG85_RS00970	COG2982	Protein involved in outer membrane biogenesis
CRG85_RS00975	COG0477	Major facilitator Superfamily
CRG85_RS00980	COG1295	ribonuclease BN
CRG85_RS00985	COG0583	DNA-binding transcription factor activity
CRG85_RS00990	COG2197	response regulator
CRG85_RS01000	COG1858	cytochrome C peroxidase
CRG85_RS01005	COG0076	glutamate decarboxylase activity
CRG85_RS01010	COG2207	Transcriptional regulator
CRG85_RS01015	COG2207	Transcriptional regulator
CRG85_RS01020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRG85_RS01025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS01035	COG2771	luxR family
CRG85_RS01040	COG3247	response to pH
CRG85_RS01055	COG1285	pathogenesis
CRG85_RS01060	COG2197	response regulator
CRG85_RS01065	COG3065	identical protein binding
CRG85_RS01075	COG1393	Belongs to the ArsC family
CRG85_RS01080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRG85_RS01085	COG0640	Transcriptional regulator
CRG85_RS01095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRG85_RS01100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CRG85_RS01105	COG0339	signal peptide processing
CRG85_RS01115	COG3104	oligopeptide transport
CRG85_RS01120	COG0589	response to stress
CRG85_RS01130	COG0306	phosphate transporter
CRG85_RS01135	COG2081	HI0933 family
CRG85_RS01155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS01160	COG1129	ABC transporter
CRG85_RS01160	COG0842	Transport permease protein
CRG85_RS01165	COG0842	Transport permease protein
CRG85_RS01175	COG1413	lyase activity
CRG85_RS01185	COG3209	COG3209 Rhs family protein
CRG85_RS01200	COG0444	Belongs to the ABC transporter superfamily
CRG85_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRG85_RS01210	COG0601	transmembrane transport
CRG85_RS01215	COG0747	negative chemotaxis
CRG85_RS01220	COG2091	lysine biosynthetic process via aminoadipic acid
CRG85_RS01225	COG0628	permease
CRG85_RS01230	COG0477	Major facilitator Superfamily
CRG85_RS01240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CRG85_RS01255	COG3714	YhhN family
CRG85_RS01265	COG3776	membrane
CRG85_RS01270	COG0742	ribosomal rna small subunit methyltransferase
CRG85_RS01275	COG0552	protein localization to endoplasmic reticulum
CRG85_RS01280	COG2884	Cell division ATP-binding protein ftsE
CRG85_RS01285	COG2177	Part of the ABC transporter FtsEX involved in
CRG85_RS01290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRG85_RS01295	COG0683	leucine binding
CRG85_RS01300	COG0456	acetyltransferase
CRG85_RS01305	COG0683	leucine binding
CRG85_RS01310	COG0559	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS01315	COG4177	L-phenylalanine transmembrane transporter activity
CRG85_RS01320	COG0411	ABC transporter
CRG85_RS01325	COG0410	ABC transporter
CRG85_RS01330	COG1653	transport
CRG85_RS01335	COG1175	transmembrane transport
CRG85_RS01340	COG0395	ABC-type sugar transport system, permease component
CRG85_RS01345	COG3842	ATPase activity
CRG85_RS01350	COG0584	glycerophosphoryl diester phosphodiesterase
CRG85_RS01360	COG0405	Gamma-glutamyltransferase
CRG85_RS01385	COG3157	Type VI secretion system effector, Hcp
CRG85_RS01390	COG1247	-acetyltransferase
CRG85_RS01395	COG0673	inositol 2-dehydrogenase activity
CRG85_RS01400	COG1741	Belongs to the pirin family
CRG85_RS01405	COG1609	Transcriptional regulator
CRG85_RS01410	COG3265	gluconokinase activity
CRG85_RS01415	COG2610	gluconate transmembrane transporter activity
CRG85_RS01420	COG2095	MarC family integral membrane protein
CRG85_RS01425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRG85_RS01450	COG0058	SHG alpha-glucan phosphorylase activity
CRG85_RS01455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRG85_RS01470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRG85_RS01485	COG1349	DNA-binding transcription factor activity
CRG85_RS01490	COG4650	regulator
CRG85_RS01495	COG1690	Belongs to the RtcB family
CRG85_RS01510	COG0058	SHG alpha-glucan phosphorylase activity
CRG85_RS01515	COG1640	4-alpha-glucanotransferase
CRG85_RS01520	COG2610	gluconate transmembrane transporter activity
CRG85_RS01540	COG5464	transposase or invertase
CRG85_RS01550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CRG85_RS01555	COG1918	ferrous iron import across plasma membrane
CRG85_RS01560	COG2183	response to ionizing radiation
CRG85_RS01565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRG85_RS01585	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CRG85_RS01595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRG85_RS01600	COG1011	Hydrolase
CRG85_RS01610	COG0494	nUDIX hydrolase
CRG85_RS01615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CRG85_RS01620	COG4972	Pilus assembly protein
CRG85_RS01625	COG3166	PFAM Fimbrial assembly family protein
CRG85_RS01640	COG4796	Type ii and iii secretion system protein
CRG85_RS01655	COG3266	domain, Protein
CRG85_RS01660	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CRG85_RS01665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRG85_RS01670	COG0546	phosphoglycolate phosphatase activity
CRG85_RS01675	COG0180	Tryptophanyl-tRNA synthetase
CRG85_RS01685	COG2188	Transcriptional regulator
CRG85_RS01695	COG3457	Alanine racemase
CRG85_RS01700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CRG85_RS01705	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CRG85_RS01720	COG0626	cystathionine gamma-synthase activity
CRG85_RS01725	COG2188	Transcriptional regulator
CRG85_RS01730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS01735	COG1082	Xylose isomerase domain protein TIM barrel
CRG85_RS01740	COG2222	sugar isomerase
CRG85_RS01745	COG0531	amino acid
CRG85_RS01760	COG2116	formate transmembrane transporter activity
CRG85_RS01765	COG2146	nitrite reductase [NAD(P)H] activity
CRG85_RS01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRG85_RS01780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRG85_RS01790	COG2184	nucleotidyltransferase activity
CRG85_RS01795	COG0512	Glutamine amidotransferase of anthranilate synthase
CRG85_RS01800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRG85_RS01805	COG1289	transmembrane transporter activity
CRG85_RS01810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRG85_RS01815	COG1765	OsmC-like protein
CRG85_RS01820	COG3954	Phosphoribulokinase
CRG85_RS01830	COG0429	hydrolase of the alpha beta-hydrolase fold
CRG85_RS01835	COG0488	(ABC) transporter
CRG85_RS01850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CRG85_RS01855	COG1047	Peptidyl-prolyl cis-trans
CRG85_RS01865	COG0545	Peptidyl-prolyl cis-trans isomerase
CRG85_RS01870	COG2964	Protein conserved in bacteria
CRG85_RS01910	COG3979	chitinase
CRG85_RS01915	COG2906	2 iron, 2 sulfur cluster binding
CRG85_RS01920	COG2193	ferroxidase activity
CRG85_RS01925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CRG85_RS01930	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CRG85_RS01935	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CRG85_RS01940	COG3156	type II secretion system protein K
CRG85_RS01945	COG4795	General secretion pathway protein
CRG85_RS01950	COG2165	general secretion pathway protein
CRG85_RS01955	COG2165	general secretion pathway protein
CRG85_RS01960	COG2165	general secretion pathway protein
CRG85_RS01965	COG1459	type II secretion system
CRG85_RS01975	COG1450	Type ii and iii secretion system protein
CRG85_RS01980	COG3031	protein transport across the cell outer membrane
CRG85_RS01985	COG3267	Type II secretory pathway component ExeA
CRG85_RS01985	COG3409	Peptidoglycan-binding domain 1 protein
CRG85_RS02010	COG0089	rRNA binding
CRG85_RS02100	COG0201	protein transport
CRG85_RS02140	COG0789	Transcriptional regulator
CRG85_RS02145	COG3036	rescue of stalled ribosome
CRG85_RS02155	COG0569	domain protein
CRG85_RS02175	COG0758	DNA mediated transformation
CRG85_RS02185	COG0551	DNA topoisomerase type I activity
CRG85_RS02205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CRG85_RS02245	COG1126	abc transporter atp-binding protein
CRG85_RS02250	COG0765	amino acid transport
CRG85_RS02255	COG4597	amino acid ABC transporter
CRG85_RS02260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS02280	COG1309	transcriptional regulator
CRG85_RS02290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CRG85_RS02300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRG85_RS02310	COG4145	pantothenate transmembrane transporter activity
CRG85_RS02315	COG3924	membrane
CRG85_RS02320	COG0439	Biotin carboxylase
CRG85_RS02325	COG0511	ligase activity, forming carbon-carbon bonds
CRG85_RS02335	COG0604	alcohol dehydrogenase
CRG85_RS02340	COG2199	diguanylate cyclase activity
CRG85_RS02340	COG2200	EAL domain
CRG85_RS02350	COG1077	Cell shape determining protein MreB Mrl
CRG85_RS02355	COG1792	Involved in formation and maintenance of cell shape
CRG85_RS02360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CRG85_RS02370	COG1530	ribonuclease E activity
CRG85_RS02375	COG3164	Protein of unknown function
CRG85_RS02380	COG0312	modulator of DNA gyrase
CRG85_RS02385	COG0583	DNA-binding transcription factor activity
CRG85_RS02405	COG2732	(Barnase) inhibitor
CRG85_RS02425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRG85_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRG85_RS02435	COG3105	Protein conserved in bacteria
CRG85_RS02440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CRG85_RS02460	COG0625	glutathione transferase activity
CRG85_RS02465	COG2969	positive regulation of protein catabolic process
CRG85_RS02470	COG3069	C4-dicarboxylate transmembrane transporter activity
CRG85_RS02500	COG2731	YhcH YjgK YiaL family protein
CRG85_RS02510	COG4804	nuclease activity
CRG85_RS02515	COG0493	'glutamate synthase
CRG85_RS02520	COG0067	glutamate synthase
CRG85_RS02520	COG0069	glutamate synthase activity
CRG85_RS02520	COG0070	glutamate synthase
CRG85_RS02525	COG1242	4 iron, 4 sulfur cluster binding
CRG85_RS02530	COG0784	Response regulator, receiver
CRG85_RS02530	COG2198	Histidine kinase
CRG85_RS02530	COG5002	protein histidine kinase activity
CRG85_RS02535	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CRG85_RS02545	COG0515	serine threonine protein kinase
CRG85_RS02550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS02565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRG85_RS02570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CRG85_RS02575	COG1137	ATPase activity
CRG85_RS02580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CRG85_RS02585	COG3117	lipopolysaccharide transmembrane transporter activity
CRG85_RS02590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CRG85_RS02595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRG85_RS02595	COG0517	IMP dehydrogenase activity
CRG85_RS02600	COG0530	calcium, potassium:sodium antiporter activity
CRG85_RS02605	COG1127	ABC transporter
CRG85_RS02610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRG85_RS02615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRG85_RS02620	COG2854	intermembrane phospholipid transfer
CRG85_RS02625	COG3113	response to antibiotic
CRG85_RS02630	COG5007	Belongs to the BolA IbaG family
CRG85_RS02640	COG3423	Transcriptional regulator
CRG85_RS02645	COG0142	geranyltranstransferase activity
CRG85_RS02660	COG0697	spore germination
CRG85_RS02670	COG2027	D-alanyl-D-alanine carboxypeptidase
CRG85_RS02675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRG85_RS02680	COG1534	Rna-binding protein
CRG85_RS02690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRG85_RS02695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRG85_RS02705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRG85_RS02735	COG0195	Participates in both transcription termination and antitermination
CRG85_RS02775	COG0513	Belongs to the DEAD box helicase family
CRG85_RS02780	COG0814	amino acid
CRG85_RS02790	COG3547	Transposase (IS116 IS110 IS902 family)
CRG85_RS02795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRG85_RS02800	COG0826	peptidase U32
CRG85_RS02805	COG0826	peptidase U32
CRG85_RS02810	COG3154	lipid carrier protein
CRG85_RS02815	COG3153	acetyltransferase
CRG85_RS02830	COG0693	protein deglycase activity
CRG85_RS02835	COG0702	epimerase
CRG85_RS02840	COG0701	Predicted permease
CRG85_RS02845	COG2823	Periplasmic or secreted lipoprotein
CRG85_RS02865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CRG85_RS02870	COG3539	Fimbrial protein
CRG85_RS02875	COG3188	usher protein
CRG85_RS02880	COG3121	Chaperone
CRG85_RS02885	COG3539	Fimbrial protein
CRG85_RS02890	COG0363	glucosamine-6-phosphate deaminase activity
CRG85_RS02895	COG3716	PTS system mannose fructose sorbose family IID component
CRG85_RS02900	COG3715	PTS system
CRG85_RS02905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS02915	COG2222	sugar isomerase
CRG85_RS02920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRG85_RS02925	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS02930	COG3716	PTS system mannose fructose sorbose family IID component
CRG85_RS02940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS02950	COG1349	DNA-binding transcription factor activity
CRG85_RS02960	COG2002	toxin-antitoxin pair type II binding
CRG85_RS02965	COG2721	sulfolactate sulfo-lyase activity
CRG85_RS02970	COG2271	Major facilitator Superfamily
CRG85_RS02980	COG2084	Dehydrogenase
CRG85_RS02985	COG1929	Belongs to the glycerate kinase type-1 family
CRG85_RS03010	COG0583	DNA-binding transcription factor activity
CRG85_RS03015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRG85_RS03025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRG85_RS03030	COG1882	Formate acetyltransferase
CRG85_RS03035	COG0251	oxidation-reduction process
CRG85_RS03040	COG1760	l-serine dehydratase
CRG85_RS03045	COG0814	amino acid
CRG85_RS03060	COG1741	Belongs to the pirin family
CRG85_RS03065	COG0583	DNA-binding transcription factor activity
CRG85_RS03070	COG3152	Membrane
CRG85_RS03075	COG3152	Membrane
CRG85_RS03080	COG0435	Glutathione S-transferase
CRG85_RS03085	COG2259	Doxx family
CRG85_RS03095	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CRG85_RS03100	COG4575	ribosome binding
CRG85_RS03105	COG1422	Protein of unknown function (DUF1090)
CRG85_RS03115	COG0586	Pfam SNARE associated Golgi protein
CRG85_RS03120	COG2186	Transcriptional regulator
CRG85_RS03145	COG2271	Major facilitator Superfamily
CRG85_RS03155	COG2721	sulfolactate sulfo-lyase activity
CRG85_RS03170	COG0861	Integral membrane protein TerC family
CRG85_RS03175	COG0673	inositol 2-dehydrogenase activity
CRG85_RS03185	COG1451	nucleotide metabolic process
CRG85_RS03200	COG5499	transcription regulator containing HTH domain
CRG85_RS03205	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRG85_RS03205	COG1902	pentaerythritol trinitrate reductase activity
CRG85_RS03210	COG3408	Glycogen debranching enzyme
CRG85_RS03210	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CRG85_RS03220	COG0531	amino acid
CRG85_RS03225	COG2731	YhcH YjgK YiaL family protein
CRG85_RS03230	COG3250	beta-galactosidase activity
CRG85_RS03235	COG1609	Transcriptional regulator
CRG85_RS03240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRG85_RS03250	COG0840	transmembrane signaling receptor activity
CRG85_RS03255	COG1695	Transcriptional regulator
CRG85_RS03265	COG2375	cellular response to nickel ion
CRG85_RS03280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRG85_RS03285	COG0358	DNA primase activity
CRG85_RS03290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CRG85_RS03305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRG85_RS03310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRG85_RS03315	COG0583	DNA-binding transcription factor activity
CRG85_RS03325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRG85_RS03340	COG4991	sh3 domain protein
CRG85_RS03345	COG3025	triphosphatase activity
CRG85_RS03370	COG2268	Band 7 protein
CRG85_RS03375	COG1585	Membrane protein implicated in regulation of membrane protease activity
CRG85_RS03385	COG3539	Fimbrial protein
CRG85_RS03390	COG3121	Chaperone
CRG85_RS03395	COG3188	usher protein
CRG85_RS03400	COG3539	Fimbrial protein
CRG85_RS03405	COG2960	long-chain fatty acid transporting porin activity
CRG85_RS03420	COG3384	dioxygenase
CRG85_RS03425	COG0754	glutathionylspermidine amidase activity
CRG85_RS03435	COG1538	Outer membrane efflux protein
CRG85_RS03440	COG0494	nUDIX hydrolase
CRG85_RS03445	COG3151	Protein conserved in bacteria
CRG85_RS03450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRG85_RS03455	COG3150	esterase
CRG85_RS03460	COG0187	DNA topoisomerase II activity
CRG85_RS03465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CRG85_RS03470	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRG85_RS03480	COG0642	Histidine kinase
CRG85_RS03485	COG0745	RESPONSE REGULATOR receiver
CRG85_RS03490	COG3111	PFAM Bacterial OB fold (BOF) protein
CRG85_RS03495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CRG85_RS03500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRG85_RS03505	COG0204	Acyl-transferase
CRG85_RS03510	COG2132	Multicopper oxidase
CRG85_RS03515	COG1032	radical SAM domain protein
CRG85_RS03520	COG4238	major outer membrane lipoprotein
CRG85_RS03530	COG0656	L-ascorbic acid biosynthetic process
CRG85_RS03535	COG1979	alcohol dehydrogenase
CRG85_RS03540	COG2207	Transcriptional regulator
CRG85_RS03545	COG0586	Pfam SNARE associated Golgi protein
CRG85_RS03550	COG0626	cystathionine gamma-synthase activity
CRG85_RS03555	COG0811	peptide transport
CRG85_RS03560	COG0848	biopolymer transport protein
CRG85_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS03575	COG0667	Aldo Keto reductase
CRG85_RS03590	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRG85_RS03595	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS03600	COG5557	Pfam Polysulphide reductase, NrfD
CRG85_RS03605	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CRG85_RS03610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRG85_RS03615	COG1773	rubredoxin
CRG85_RS03625	COG0298	carbon dioxide binding
CRG85_RS03630	COG0625	glutathione transferase activity
CRG85_RS03635	COG0754	glutathionylspermidine amidase activity
CRG85_RS03640	COG0306	phosphate transporter
CRG85_RS03645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRG85_RS03650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRG85_RS03655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRG85_RS03660	COG2244	polysaccharide biosynthetic process
CRG85_RS03670	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CRG85_RS03675	COG0795	lipopolysaccharide-transporting ATPase activity
CRG85_RS03685	COG0156	8-amino-7-oxononanoate synthase activity
CRG85_RS03690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRG85_RS03700	COG0318	PFAM AMP-dependent synthetase and ligase
CRG85_RS03705	COG0456	acetyltransferase
CRG85_RS03710	COG2186	Transcriptional regulator
CRG85_RS03715	COG0277	FAD linked oxidase domain protein
CRG85_RS03720	COG0277	FAD linked oxidase domain protein
CRG85_RS03725	COG0247	lactate metabolic process
CRG85_RS03730	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CRG85_RS03735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRG85_RS03740	COG1620	l-lactate permease
CRG85_RS03770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRG85_RS03775	COG1459	type II secretion system
CRG85_RS03780	COG2165	general secretion pathway protein
CRG85_RS03810	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CRG85_RS03820	COG1811	Na channel or pump
CRG85_RS03825	COG1982	Orn Lys Arg decarboxylase major
CRG85_RS03830	COG2211	Major facilitator Superfamily
CRG85_RS03845	COG1194	a g-specific adenine glycosylase
CRG85_RS03855	COG3171	Protein conserved in bacteria
CRG85_RS03865	COG0252	asparaginase activity
CRG85_RS03875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRG85_RS03890	COG0762	integral membrane protein
CRG85_RS03895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRG85_RS03900	COG2805	Type II/IV secretion system protein
CRG85_RS03915	COG0189	ligase activity
CRG85_RS03920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRG85_RS03925	COG2356	endonuclease I
CRG85_RS03935	COG2814	Major facilitator Superfamily
CRG85_RS03960	COG1166	arginine decarboxylase activity
CRG85_RS03970	COG0501	Belongs to the peptidase M48B family
CRG85_RS03975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRG85_RS03980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS03990	COG1063	alcohol dehydrogenase
CRG85_RS03995	COG1494	fructose-1,6-bisphosphatase
CRG85_RS04000	COG3722	fumarate hydratase activity
CRG85_RS04005	COG1072	(Pantothenic acid kinase))
CRG85_RS04020	COG0191	fructose-bisphosphate aldolase activity
CRG85_RS04025	COG0668	transmembrane transport
CRG85_RS04030	COG1279	arginine transmembrane transporter activity
CRG85_RS04035	COG2968	Membrane
CRG85_RS04040	COG0583	DNA-binding transcription factor activity
CRG85_RS04045	COG0427	acetyl-CoA hydrolase
CRG85_RS04050	COG1024	Enoyl-CoA hydratase
CRG85_RS04055	COG1703	isobutyryl-CoA mutase activity
CRG85_RS04060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRG85_RS04060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRG85_RS04080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRG85_RS04090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRG85_RS04110	COG0006	proline dipeptidase activity
CRG85_RS04115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRG85_RS04120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRG85_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS04150	COG2723	6-phospho-beta-galactosidase activity
CRG85_RS04160	COG1272	protein, Hemolysin III
CRG85_RS04170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CRG85_RS04180	COG0716	FMN binding
CRG85_RS04185	COG4974	Belongs to the 'phage' integrase family
CRG85_RS04190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRG85_RS04195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CRG85_RS04205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRG85_RS04225	COG2233	PERMEase
CRG85_RS04230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS04230	COG0493	'glutamate synthase
CRG85_RS04235	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS04240	COG2252	PERMEase
CRG85_RS04245	COG0402	S-adenosylhomocysteine deaminase activity
CRG85_RS04250	COG2233	PERMEase
CRG85_RS04255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRG85_RS04255	COG2080	2 iron, 2 sulfur cluster binding
CRG85_RS04260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CRG85_RS04265	COG0402	S-adenosylhomocysteine deaminase activity
CRG85_RS04270	COG0493	'glutamate synthase
CRG85_RS04270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS04275	COG2068	MobA-Related Protein
CRG85_RS04280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRG85_RS04285	COG3608	succinylglutamate desuccinylase aspartoacylase
CRG85_RS04285	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CRG85_RS04290	COG0549	Belongs to the carbamate kinase family
CRG85_RS04300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRG85_RS04305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRG85_RS04310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRG85_RS04315	COG3829	transcription factor binding
CRG85_RS04320	COG2080	2 iron, 2 sulfur cluster binding
CRG85_RS04325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CRG85_RS04330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRG85_RS04335	COG4942	peptidase
CRG85_RS04385	COG3387	PFAM Glycoside hydrolase 15-related
CRG85_RS04475	COG2197	response regulator
CRG85_RS04490	COG3710	Transcriptional regulator
CRG85_RS04490	COG0457	Tetratricopeptide repeat
CRG85_RS04495	COG0457	Tetratricopeptide repeat
CRG85_RS04525	COG3710	Transcriptional regulator
CRG85_RS04530	COG2771	luxR family
CRG85_RS04535	COG0814	amino acid
CRG85_RS04540	COG0183	Belongs to the thiolase family
CRG85_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS04555	COG2814	Major facilitator Superfamily
CRG85_RS04560	COG1794	racemase activity, acting on amino acids and derivatives
CRG85_RS04565	COG0583	DNA-binding transcription factor activity
CRG85_RS04575	COG1609	Transcriptional regulator
CRG85_RS04590	COG0667	Aldo Keto reductase
CRG85_RS04600	COG0861	Integral membrane protein TerC family
CRG85_RS04620	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CRG85_RS04640	COG2165	general secretion pathway protein
CRG85_RS04645	COG4795	General secretion pathway protein
CRG85_RS04655	COG4967	type IV pilus modification protein PilV
CRG85_RS04660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CRG85_RS04665	COG1025	Belongs to the peptidase M16 family
CRG85_RS04670	COG1074	ATP-dependent DNA helicase activity
CRG85_RS04675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRG85_RS04680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRG85_RS04680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CRG85_RS04685	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRG85_RS04705	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CRG85_RS04710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CRG85_RS04715	COG2166	iron-sulfur cluster assembly
CRG85_RS04720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRG85_RS04730	COG0583	DNA-binding transcription factor activity
CRG85_RS04735	COG2363	Small membrane protein
CRG85_RS04745	COG1349	DNA-binding transcription factor activity
CRG85_RS04755	COG1070	Carbohydrate kinase
CRG85_RS04765	COG1129	ABC transporter
CRG85_RS04770	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS04775	COG1609	Transcriptional regulator
CRG85_RS04780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRG85_RS04790	COG0235	Class ii aldolase
CRG85_RS04795	COG1454	alcohol dehydrogenase
CRG85_RS04805	COG1760	l-serine dehydratase
CRG85_RS04810	COG0814	amino acid
CRG85_RS04815	COG1611	Belongs to the LOG family
CRG85_RS04830	COG3098	single-species biofilm formation
CRG85_RS04835	COG0564	pseudouridine synthase activity
CRG85_RS04840	COG0716	FMN binding
CRG85_RS04845	COG2271	Major facilitator Superfamily
CRG85_RS04850	COG4948	Mandelate Racemase Muconate Lactonizing
CRG85_RS04855	COG4948	Mandelate Racemase Muconate Lactonizing
CRG85_RS04860	COG3850	Histidine kinase
CRG85_RS04860	COG4999	Histidine kinase
CRG85_RS04860	COG3437	response regulator, receiver
CRG85_RS04860	COG2205	protein histidine kinase activity
CRG85_RS04865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRG85_RS04870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRG85_RS04875	COG2336	PFAM SpoVT AbrB
CRG85_RS04880	COG2337	Toxic component of a toxin-antitoxin (TA) module
CRG85_RS04885	COG3956	TIGRFAM MazG family protein
CRG85_RS04900	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CRG85_RS04910	COG0602	queuosine metabolic process
CRG85_RS04915	COG1070	Carbohydrate kinase
CRG85_RS04920	COG2223	nitrite transmembrane transporter activity
CRG85_RS04925	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS04930	COG0277	FAD linked oxidase domain protein
CRG85_RS04935	COG0477	Major facilitator Superfamily
CRG85_RS04940	COG2086	electron transfer activity
CRG85_RS04945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRG85_RS04950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CRG85_RS04955	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CRG85_RS04960	COG0644	oxidoreductase
CRG85_RS04965	COG0720	synthase
CRG85_RS04995	COG1203	CRISPR-associated helicase, Cas3
CRG85_RS05010	COG1857	crispr-associated protein
CRG85_RS05025	COG1518	maintenance of DNA repeat elements
CRG85_RS05030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRG85_RS05035	COG2234	aminopeptidase activity
CRG85_RS05090	COG1388	LysM domain
CRG85_RS05090	COG4942	peptidase
CRG85_RS05095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRG85_RS05100	COG2610	gluconate transmembrane transporter activity
CRG85_RS05105	COG3622	Belongs to the hyi family
CRG85_RS05110	COG0235	Class ii aldolase
CRG85_RS05115	COG3395	kinase activity
CRG85_RS05120	COG2084	Dehydrogenase
CRG85_RS05125	COG1349	DNA-binding transcription factor activity
CRG85_RS05130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRG85_RS05150	COG3604	Transcriptional regulator
CRG85_RS05155	COG0309	Hydrogenase expression formation protein (HypE)
CRG85_RS05160	COG0409	Hydrogenase expression formation protein
CRG85_RS05165	COG0298	carbon dioxide binding
CRG85_RS05170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRG85_RS05175	COG0375	protein maturation
CRG85_RS05190	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS05195	COG0651	ATP synthesis coupled electron transport
CRG85_RS05200	COG0650	Formate hydrogenlyase subunit 4
CRG85_RS05205	COG3261	NADH dehydrogenase
CRG85_RS05205	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CRG85_RS05210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG85_RS05215	COG3260	NADH ubiquinone oxidoreductase 20
CRG85_RS05225	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRG85_RS05230	COG2723	6-phospho-beta-galactosidase activity
CRG85_RS05235	COG1263	PTS System
CRG85_RS05235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS05240	COG1609	Transcriptional regulator
CRG85_RS05245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS05250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRG85_RS05270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRG85_RS05270	COG0517	IMP dehydrogenase activity
CRG85_RS05275	COG1349	DNA-binding transcription factor activity
CRG85_RS05280	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS05295	COG3732	PTS system glucitol sorbitol-specific
CRG85_RS05300	COG3730	PTS system glucitol sorbitol-specific
CRG85_RS05305	COG2951	lytic endotransglycosylase activity
CRG85_RS05310	COG1546	Belongs to the CinA family
CRG85_RS05330	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CRG85_RS05360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRG85_RS05365	COG1238	metal cluster binding
CRG85_RS05380	COG2814	Major facilitator Superfamily
CRG85_RS05385	COG1566	PFAM secretion protein HlyD family protein
CRG85_RS05390	COG1846	Transcriptional regulator
CRG85_RS05400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CRG85_RS05405	COG2814	Major facilitator Superfamily
CRG85_RS05415	COG2113	Glycine betaine
CRG85_RS05420	COG4176	ABC-type proline glycine betaine transport system permease component
CRG85_RS05425	COG4175	Glycine betaine
CRG85_RS05435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRG85_RS05440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRG85_RS05450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRG85_RS05455	COG4575	ribosome binding
CRG85_RS05470	COG2916	Histone family protein nucleoid-structuring protein H-NS
CRG85_RS05475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRG85_RS05480	COG0640	Transcriptional regulator
CRG85_RS05485	COG0401	homolog of Blt101
CRG85_RS05490	COG1652	LysM domain
CRG85_RS05495	COG1802	Transcriptional regulator
CRG85_RS05500	COG1113	amino acid transport
CRG85_RS05505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRG85_RS05510	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS05515	COG0579	oxidoreductase
CRG85_RS05530	COG0366	Alpha amylase catalytic
CRG85_RS05535	COG0366	Alpha amylase catalytic
CRG85_RS05555	COG1475	DNA binding
CRG85_RS05565	COG0582	viral genome integration into host DNA
CRG85_RS05575	COG4974	Belongs to the 'phage' integrase family
CRG85_RS05610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRG85_RS05725	COG2867	negative regulation of translational initiation
CRG85_RS05735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRG85_RS05740	COG0497	DNA recombination
CRG85_RS05760	COG4536	flavin adenine dinucleotide binding
CRG85_RS05765	COG4137	Cytochrome C assembly protein
CRG85_RS05770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRG85_RS05795	COG2885	chlorophyll binding
CRG85_RS05800	COG2199	diguanylate cyclase activity
CRG85_RS05815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRG85_RS05820	COG0287	Prephenate dehydrogenase
CRG85_RS05820	COG1605	Chorismate mutase
CRG85_RS05825	COG0077	Prephenate dehydratase
CRG85_RS05825	COG1605	Chorismate mutase
CRG85_RS05835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRG85_RS05840	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRG85_RS05845	COG0564	pseudouridine synthase activity
CRG85_RS05850	COG1496	oxidoreductase activity
CRG85_RS05855	COG0542	response to heat
CRG85_RS05880	COG0477	Major facilitator Superfamily
CRG85_RS05885	COG5544	Lipoprotein
CRG85_RS05890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRG85_RS05895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRG85_RS05895	COG0045	succinate-CoA ligase (ADP-forming) activity
CRG85_RS05895	COG1042	CoA-binding domain protein
CRG85_RS05900	COG3148	PFAM DTW domain containing protein
CRG85_RS05905	COG3118	belongs to the thioredoxin family
CRG85_RS05910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRG85_RS05930	COG0583	DNA-binding transcription factor activity
CRG85_RS05935	COG0513	Belongs to the DEAD box helicase family
CRG85_RS05945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CRG85_RS05955	COG1595	DNA-templated transcription, initiation
CRG85_RS05960	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CRG85_RS05965	COG3026	antisigma factor binding
CRG85_RS05970	COG3086	response to oxidative stress
CRG85_RS05980	COG0681	Belongs to the peptidase S26 family
CRG85_RS06000	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CRG85_RS06015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS06020	COG1737	Transcriptional regulator
CRG85_RS06025	COG0560	Phosphoserine phosphatase
CRG85_RS06030	COG0590	tRNA wobble adenosine to inosine editing
CRG85_RS06045	COG2205	protein histidine kinase activity
CRG85_RS06050	COG3170	Tfp pilus assembly protein FimV
CRG85_RS06055	COG2204	response regulator
CRG85_RS06060	COG0347	Belongs to the P(II) protein family
CRG85_RS06065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG85_RS06065	COG1017	nitric oxide dioxygenase activity
CRG85_RS06075	COG1940	carbohydrate kinase activity
CRG85_RS06080	COG0457	Tetratricopeptide repeat
CRG85_RS06085	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS06090	COG1129	ABC transporter
CRG85_RS06095	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS06100	COG1063	alcohol dehydrogenase
CRG85_RS06105	COG2017	converts alpha-aldose to the beta-anomer
CRG85_RS06110	COG2259	Doxx family
CRG85_RS06135	COG4638	Rieske (2fe-2S)
CRG85_RS06140	COG0583	DNA-binding transcription factor activity
CRG85_RS06145	COG2814	Major facilitator Superfamily
CRG85_RS06150	COG3711	transcriptional antiterminator
CRG85_RS06155	COG1073	alpha beta
CRG85_RS06160	COG0483	inositol monophosphate 1-phosphatase activity
CRG85_RS06180	COG0822	iron-sulfur transferase activity
CRG85_RS06200	COG0633	Ferredoxin
CRG85_RS06205	COG2975	iron-sulfur cluster assembly
CRG85_RS06220	COG2897	thiosulfate sulfurtransferase activity
CRG85_RS06225	COG2373	Large extracellular alpha-helical protein
CRG85_RS06230	COG4953	penicillin-binding protein 1C
CRG85_RS06260	COG2976	Protein conserved in bacteria
CRG85_RS06275	COG1645	bacterial-type flagellum-dependent swarming motility
CRG85_RS06285	COG0517	IMP dehydrogenase activity
CRG85_RS06285	COG0516	GMP reductase activity
CRG85_RS06300	COG3133	Outer membrane lipoprotein
CRG85_RS06310	COG2200	EAL domain
CRG85_RS06315	COG0248	Ppx GppA phosphatase
CRG85_RS06320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRG85_RS06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRG85_RS06340	COG2233	PERMEase
CRG85_RS06350	COG1393	Belongs to the ArsC family
CRG85_RS06355	COG4783	chaperone-mediated protein folding
CRG85_RS06360	COG0628	permease
CRG85_RS06365	COG2116	formate transmembrane transporter activity
CRG85_RS06370	COG3604	Transcriptional regulator
CRG85_RS06380	COG3260	NADH ubiquinone oxidoreductase 20
CRG85_RS06385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG85_RS06390	COG3261	NADH dehydrogenase
CRG85_RS06390	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CRG85_RS06395	COG0651	ATP synthesis coupled electron transport
CRG85_RS06400	COG4237	Hydrogenase 4 membrane
CRG85_RS06410	COG0650	Formate hydrogenlyase subunit 4
CRG85_RS06420	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS06425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRG85_RS06430	COG2716	regulation of RNA biosynthetic process
CRG85_RS06440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CRG85_RS06460	COG2321	neutral zinc metallopeptidase
CRG85_RS06465	COG1444	tRNA N-acetyltransferase activity
CRG85_RS06470	COG0400	carboxylic ester hydrolase activity
CRG85_RS06485	COG1393	Belongs to the ArsC family
CRG85_RS06495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRG85_RS06500	COG3850	Histidine kinase
CRG85_RS06505	COG0493	'glutamate synthase
CRG85_RS06505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS06515	COG5342	invasion associated locus B
CRG85_RS06520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRG85_RS06525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRG85_RS06530	COG0281	malic enzyme
CRG85_RS06530	COG0280	phosphate acetyltransferase
CRG85_RS06535	COG4810	utilization protein
CRG85_RS06540	COG4917	ethanolamine utilization protein
CRG85_RS06545	COG4766	ethanolamine catabolic process
CRG85_RS06550	COG4812	Cobalamin adenosyltransferase
CRG85_RS06555	COG0280	phosphate acetyltransferase
CRG85_RS06560	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CRG85_RS06565	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CRG85_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS06575	COG4820	ethanolamine utilization protein (EutJ)
CRG85_RS06580	COG1454	alcohol dehydrogenase
CRG85_RS06585	COG3192	ethanolamine utilization protein
CRG85_RS06590	COG4819	ethanolamine utilization protein
CRG85_RS06595	COG4303	Ethanolamine ammonia lyase large subunit
CRG85_RS06605	COG4816	utilization protein
CRG85_RS06610	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CRG85_RS06615	COG2207	Transcriptional regulator
CRG85_RS06625	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRG85_RS06630	COG0456	acetyltransferase
CRG85_RS06645	COG2837	iron assimilation
CRG85_RS06650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRG85_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS06675	COG4150	thiosulfate binding
CRG85_RS06680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CRG85_RS06685	COG4208	sulfate ABC transporter
CRG85_RS06690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CRG85_RS06695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRG85_RS06710	COG2190	(PTS) system
CRG85_RS06715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRG85_RS06720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS06725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRG85_RS06745	COG3530	Putative quorum-sensing-regulated virulence factor
CRG85_RS06750	COG0385	Bile acid
CRG85_RS06755	COG0583	DNA-binding transcription factor activity
CRG85_RS06765	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRG85_RS06770	COG2211	Major facilitator Superfamily
CRG85_RS06780	COG0583	DNA-binding transcription factor activity
CRG85_RS06815	COG3415	Transposase
CRG85_RS06820	COG3415	Transposase
CRG85_RS06835	COG2200	EAL domain
CRG85_RS06835	COG2199	diguanylate cyclase activity
CRG85_RS06840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRG85_RS06865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS06870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS06875	COG0006	proline dipeptidase activity
CRG85_RS06880	COG1363	Peptidase, m42
CRG85_RS06885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRG85_RS06885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS06890	COG2207	Transcriptional regulator
CRG85_RS06895	COG3279	Response regulator of the LytR AlgR family
CRG85_RS06900	COG3275	phosphorelay sensor kinase activity
CRG85_RS06905	COG0436	Aminotransferase
CRG85_RS06915	COG1560	Kdo2-lipid A biosynthetic process
CRG85_RS06940	COG0028	Belongs to the TPP enzyme family
CRG85_RS06945	COG0679	Auxin Efflux Carrier
CRG85_RS06950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRG85_RS06955	COG2205	protein histidine kinase activity
CRG85_RS06955	COG2198	Histidine kinase
CRG85_RS06955	COG0784	Response regulator, receiver
CRG85_RS06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS06960	COG2197	response regulator
CRG85_RS06965	COG1566	PFAM secretion protein HlyD family protein
CRG85_RS06970	COG0477	Major facilitator Superfamily
CRG85_RS06980	COG2610	gluconate transmembrane transporter activity
CRG85_RS06985	COG0583	DNA-binding transcription factor activity
CRG85_RS07025	COG2199	diguanylate cyclase activity
CRG85_RS07035	COG1979	alcohol dehydrogenase
CRG85_RS07040	COG4977	sequence-specific DNA binding
CRG85_RS07050	COG0582	viral genome integration into host DNA
CRG85_RS07060	COG2116	formate transmembrane transporter activity
CRG85_RS07065	COG2853	Lipoprotein
CRG85_RS07075	COG2067	long-chain fatty acid transport protein
CRG85_RS07080	COG3691	Protein conserved in bacteria
CRG85_RS07095	COG2062	phosphohistidine phosphatase, SixA
CRG85_RS07100	COG3539	Fimbrial protein
CRG85_RS07105	COG3188	usher protein
CRG85_RS07110	COG3121	Chaperone
CRG85_RS07115	COG3539	Fimbrial protein
CRG85_RS07120	COG3539	Fimbrial protein
CRG85_RS07125	COG3539	Fimbrial protein
CRG85_RS07140	COG2890	protein-(glutamine-N5) methyltransferase activity
CRG85_RS07155	COG0730	response to heat
CRG85_RS07160	COG3101	peptidyl-lysine hydroxylation
CRG85_RS07175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRG85_RS07180	COG2814	Major facilitator Superfamily
CRG85_RS07195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRG85_RS07205	COG0586	Pfam SNARE associated Golgi protein
CRG85_RS07215	COG0285	dihydrofolate synthase activity
CRG85_RS07220	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CRG85_RS07225	COG1286	toxin biosynthetic process
CRG85_RS07230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CRG85_RS07235	COG0163	prenyltransferase activity
CRG85_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS07250	COG4215	(ABC) transporter
CRG85_RS07255	COG4160	amino acid transport
CRG85_RS07260	COG4598	ABC transporter
CRG85_RS07265	COG5464	transposase or invertase
CRG85_RS07270	COG1090	epimerase
CRG85_RS07275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRG85_RS07280	COG0625	glutathione transferase activity
CRG85_RS07285	COG0625	glutathione transferase activity
CRG85_RS07290	COG0622	Phosphoesterase
CRG85_RS07295	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CRG85_RS07300	COG1288	antiporter activity
CRG85_RS07305	COG0280	phosphate acetyltransferase
CRG85_RS07305	COG0857	belongs to the CobB CobQ family
CRG85_RS07310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRG85_RS07325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRG85_RS07330	COG0471	metal ion transport
CRG85_RS07330	COG0490	domain, Protein
CRG85_RS07340	COG0436	Aminotransferase
CRG85_RS07345	COG0583	DNA-binding transcription factor activity
CRG85_RS07365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CRG85_RS07370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CRG85_RS07375	COG1034	ATP synthesis coupled electron transport
CRG85_RS07390	COG0839	Belongs to the complex I subunit 6 family
CRG85_RS07400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRG85_RS07405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG85_RS07435	COG2153	protein acetylation
CRG85_RS07440	COG4575	ribosome binding
CRG85_RS07445	COG1169	isochorismate synthase
CRG85_RS07460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CRG85_RS07470	COG0318	PFAM AMP-dependent synthetase and ligase
CRG85_RS07540	COG5464	transposase or invertase
CRG85_RS07545	COG0247	lactate metabolic process
CRG85_RS07555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRG85_RS07565	COG2271	Major facilitator Superfamily
CRG85_RS07570	COG0584	glycerophosphoryl diester phosphodiesterase
CRG85_RS07580	COG3642	lipopolysaccharide core region biosynthetic process
CRG85_RS07585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG85_RS07590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRG85_RS07595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRG85_RS07600	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS07610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRG85_RS07615	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CRG85_RS07620	COG3234	Protein of unknown function (DUF1175)
CRG85_RS07625	COG2373	Large extracellular alpha-helical protein
CRG85_RS07630	COG5445	Predicted secreted protein (DUF2300)
CRG85_RS07635	COG4676	Protein conserved in bacteria
CRG85_RS07640	COG0183	Belongs to the thiolase family
CRG85_RS07645	COG2031	fatty acid transporter
CRG85_RS07650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CRG85_RS07655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CRG85_RS07660	COG2204	response regulator
CRG85_RS07665	COG3852	Histidine kinase
CRG85_RS07670	COG2205	protein histidine kinase activity
CRG85_RS07670	COG0784	Response regulator, receiver
CRG85_RS07675	COG2197	response regulator
CRG85_RS07680	COG2198	Histidine kinase
CRG85_RS07680	COG0642	Histidine kinase
CRG85_RS07685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CRG85_RS07690	COG1477	protein flavinylation
CRG85_RS07695	COG2169	Transcriptional regulator
CRG85_RS07695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRG85_RS07700	COG3145	DNA-N1-methyladenine dioxygenase activity
CRG85_RS07705	COG4615	Cyclic peptide transporter
CRG85_RS07715	COG3547	Transposase (IS116 IS110 IS902 family)
CRG85_RS07730	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS07730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRG85_RS07735	COG3062	negative regulation of establishment of protein localization
CRG85_RS07745	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS07750	COG0348	domain, Protein
CRG85_RS07755	COG3043	anaerobic respiration
CRG85_RS07760	COG3005	denitrification pathway
CRG85_RS07765	COG4133	protoheme IX ABC transporter activity
CRG85_RS07770	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRG85_RS07775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRG85_RS07780	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRG85_RS07790	COG1138	Cytochrome C-type biogenesis protein
CRG85_RS07795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRG85_RS07800	COG4235	cytochrome complex assembly
CRG85_RS07800	COG3088	subunit of a heme lyase
CRG85_RS07805	COG2197	response regulator
CRG85_RS07825	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS07835	COG3083	sulfuric ester hydrolase activity
CRG85_RS07855	COG1061	Type III restriction enzyme res subunit
CRG85_RS07860	COG1187	pseudouridine synthase activity
CRG85_RS07865	COG2814	Major facilitator Superfamily
CRG85_RS07875	COG4172	Belongs to the ABC transporter superfamily
CRG85_RS07880	COG4239	(ABC) transporter, permease
CRG85_RS07885	COG4174	ABC transporter (Permease)
CRG85_RS07890	COG4166	transmembrane transport
CRG85_RS07895	COG2200	EAL domain
CRG85_RS07900	COG0791	NLP P60 protein
CRG85_RS07905	COG0671	phosphoesterase, PA-phosphatase related
CRG85_RS07910	COG0523	cobalamin synthesis protein
CRG85_RS07915	COG0246	Mannitol dehydrogenase
CRG85_RS07930	COG2814	Major facilitator Superfamily
CRG85_RS07935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS07935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS07940	COG1105	Belongs to the carbohydrate kinase PfkB family
CRG85_RS07945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CRG85_RS07945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS07945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS07950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS07955	COG2313	pseudouridylate synthase activity
CRG85_RS07960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRG85_RS07965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRG85_RS07975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRG85_RS07980	COG1522	sequence-specific DNA binding
CRG85_RS07980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS07990	COG2855	membrane
CRG85_RS07995	COG0583	DNA-binding transcription factor activity
CRG85_RS08000	COG0833	amino acid
CRG85_RS08005	COG4771	TonB-dependent receptor
CRG85_RS08020	COG2311	Membrane
CRG85_RS08025	COG1609	Transcriptional regulator
CRG85_RS08030	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS08035	COG1129	ABC transporter
CRG85_RS08040	COG4211	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS08045	COG0167	dihydroorotate dehydrogenase activity
CRG85_RS08045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CRG85_RS08050	COG0493	'glutamate synthase
CRG85_RS08060	COG2949	membrane
CRG85_RS08070	COG1346	cytolysis
CRG85_RS08080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRG85_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS08100	COG0586	Pfam SNARE associated Golgi protein
CRG85_RS08110	COG1686	Belongs to the peptidase S11 family
CRG85_RS08115	COG0277	FAD linked oxidase domain protein
CRG85_RS08120	COG1472	Belongs to the glycosyl hydrolase 3 family
CRG85_RS08125	COG1732	Glycine betaine
CRG85_RS08130	COG1174	glycine betaine transport
CRG85_RS08135	COG1125	glycine betaine transport
CRG85_RS08140	COG1174	glycine betaine transport
CRG85_RS08150	COG0789	Transcriptional regulator
CRG85_RS08155	COG3275	phosphorelay sensor kinase activity
CRG85_RS08160	COG3279	Response regulator of the LytR AlgR family
CRG85_RS08165	COG4807	Protein conserved in bacteria
CRG85_RS08170	COG4808	Protein conserved in bacteria
CRG85_RS08175	COG4715	Zinc finger, swim domain protein
CRG85_RS08180	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CRG85_RS08185	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CRG85_RS08190	COG0714	Associated with various cellular activities
CRG85_RS08200	COG3831	ATPase activity
CRG85_RS08205	COG3831	ATPase activity
CRG85_RS08215	COG0489	protein tyrosine kinase activity
CRG85_RS08225	COG3539	Fimbrial protein
CRG85_RS08230	COG3121	Chaperone
CRG85_RS08235	COG3188	usher protein
CRG85_RS08240	COG3539	Fimbrial protein
CRG85_RS08245	COG5455	response to cobalt ion
CRG85_RS08265	COG0351	phosphomethylpyrimidine kinase
CRG85_RS08270	COG3757	hydrolase, family 25
CRG85_RS08275	COG2188	Transcriptional regulator
CRG85_RS08280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS08285	COG1397	ADP-ribosylglycohydrolase
CRG85_RS08290	COG2211	Major facilitator Superfamily
CRG85_RS08295	COG1830	Aldolase
CRG85_RS08310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS08315	COG3414	Phosphotransferase system galactitol-specific IIB component
CRG85_RS08325	COG1063	alcohol dehydrogenase
CRG85_RS08350	COG0826	peptidase U32
CRG85_RS08360	COG0745	RESPONSE REGULATOR receiver
CRG85_RS08365	COG2205	protein histidine kinase activity
CRG85_RS08410	COG4245	von Willebrand factor, type A
CRG85_RS08415	COG0631	protein serine/threonine phosphatase activity
CRG85_RS08420	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
CRG85_RS08425	COG0443	Heat shock 70 kDa protein
CRG85_RS08430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CRG85_RS08435	COG5002	protein histidine kinase activity
CRG85_RS08435	COG3447	MASE1 domain protein
CRG85_RS08435	COG5001	Diguanylate cyclase
CRG85_RS08440	COG0572	uridine kinase
CRG85_RS08450	COG2982	Protein involved in outer membrane biogenesis
CRG85_RS08455	COG1253	flavin adenine dinucleotide binding
CRG85_RS08460	COG1596	polysaccharide export
CRG85_RS08465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRG85_RS08470	COG0489	protein tyrosine kinase activity
CRG85_RS08470	COG3206	protein involved in exopolysaccharide biosynthesis
CRG85_RS08475	COG0463	Glycosyl transferase, family 2
CRG85_RS08480	COG1045	serine acetyltransferase
CRG85_RS08485	COG0438	transferase activity, transferring glycosyl groups
CRG85_RS08495	COG1216	Glycosyl transferase, family 2
CRG85_RS08500	COG0110	maltose O-acetyltransferase activity
CRG85_RS08505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CRG85_RS08510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRG85_RS08515	COG1051	belongs to the nudix hydrolase family
CRG85_RS08520	COG0297	glycogen (starch) synthase activity
CRG85_RS08525	COG0662	Cupin 2, conserved barrel domain protein
CRG85_RS08525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CRG85_RS08530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRG85_RS08535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CRG85_RS08540	COG2244	polysaccharide biosynthetic process
CRG85_RS08545	COG2327	Polysaccharide pyruvyl transferase
CRG85_RS08550	COG0438	transferase activity, transferring glycosyl groups
CRG85_RS08560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRG85_RS08565	COG5433	transposase activity
CRG85_RS08575	COG2244	polysaccharide biosynthetic process
CRG85_RS08585	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CRG85_RS08590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRG85_RS08595	COG1051	belongs to the nudix hydrolase family
CRG85_RS08600	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CRG85_RS08600	COG0662	Cupin 2, conserved barrel domain protein
CRG85_RS08605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRG85_RS08625	COG0438	transferase activity, transferring glycosyl groups
CRG85_RS08630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CRG85_RS08635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CRG85_RS08640	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CRG85_RS08665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CRG85_RS08670	COG0131	Imidazoleglycerol-phosphate dehydratase
CRG85_RS08670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRG85_RS08680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CRG85_RS08695	COG2161	toxin-antitoxin pair type II binding
CRG85_RS08700	COG4115	mRNA cleavage
CRG85_RS08705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRG85_RS08710	COG0583	DNA-binding transcription factor activity
CRG85_RS08720	COG0531	amino acid
CRG85_RS08725	COG2391	methyltransferase activity
CRG85_RS08730	COG0425	Belongs to the sulfur carrier protein TusA family
CRG85_RS08735	COG2925	Exonuclease
CRG85_RS08740	COG1686	Belongs to the peptidase S11 family
CRG85_RS08750	COG1289	transmembrane transporter activity
CRG85_RS08795	COG2003	Belongs to the UPF0758 family
CRG85_RS08925	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CRG85_RS08940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS08965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRG85_RS08975	COG0583	DNA-binding transcription factor activity
CRG85_RS08990	COG2271	Major facilitator Superfamily
CRG85_RS09000	COG0800	Aldolase
CRG85_RS09005	COG3734	2-keto-3-deoxy-galactonokinase
CRG85_RS09010	COG2186	Transcriptional regulator
CRG85_RS09045	COG2826	transposase and inactivated derivatives, IS30 family
CRG85_RS09065	COG0477	Major facilitator Superfamily
CRG85_RS09080	COG1285	pathogenesis
CRG85_RS09100	COG1446	asparaginase
CRG85_RS09120	COG0675	Transposase, IS605 OrfB family
CRG85_RS09125	COG3069	C4-dicarboxylate transmembrane transporter activity
CRG85_RS09130	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRG85_RS09140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRG85_RS09145	COG0252	asparaginase activity
CRG85_RS09150	COG4565	transcriptional regulatory protein
CRG85_RS09155	COG2186	Transcriptional regulator
CRG85_RS09160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRG85_RS09165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRG85_RS09170	COG0165	Argininosuccinate lyase
CRG85_RS09185	COG3969	phosphoadenosine phosphosulfate
CRG85_RS09215	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CRG85_RS09230	COG1376	ErfK ybiS ycfS ynhG family protein
CRG85_RS09240	COG0583	DNA-binding transcription factor activity
CRG85_RS09245	COG0583	DNA-binding transcription factor activity
CRG85_RS09255	COG0534	Mate efflux family protein
CRG85_RS09265	COG0217	transcriptional regulatory protein
CRG85_RS09270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRG85_RS09275	COG0477	Major facilitator Superfamily
CRG85_RS09285	COG1388	LysM domain
CRG85_RS09285	COG1470	cell adhesion involved in biofilm formation
CRG85_RS09315	COG3038	cytochrome b561
CRG85_RS09320	COG3443	Belongs to the bacterial solute-binding protein 9 family
CRG85_RS09335	COG2351	hydroxyisourate hydrolase activity
CRG85_RS09340	COG0745	RESPONSE REGULATOR receiver
CRG85_RS09345	COG2205	protein histidine kinase activity
CRG85_RS09360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CRG85_RS09370	COG1418	mRNA catabolic process
CRG85_RS09375	COG0270	DNA (cytosine-5-)-methyltransferase activity
CRG85_RS09380	COG3727	T/G mismatch-specific endonuclease activity
CRG85_RS09385	COG0697	spore germination
CRG85_RS09390	COG2354	Protein conserved in bacteria
CRG85_RS09395	COG5475	Uncharacterized small protein (DUF2158)
CRG85_RS09400	COG3706	GGDEF domain
CRG85_RS09425	COG2197	response regulator
CRG85_RS09430	COG1684	flagellar biosynthetic protein fliR
CRG85_RS09435	COG1987	bacterial-type flagellum assembly
CRG85_RS09440	COG1338	Plays a role in the flagellum-specific transport system
CRG85_RS09445	COG3190	flagellar
CRG85_RS09450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRG85_RS09455	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRG85_RS09460	COG1580	Controls the rotational direction of flagella during chemotaxis
CRG85_RS09465	COG3144	bacterial-type flagellum assembly
CRG85_RS09470	COG2882	bacterial-type flagellum organization
CRG85_RS09475	COG1157	protein secretion by the type III secretion system
CRG85_RS09480	COG1317	bacterial-type flagellum organization
CRG85_RS09485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRG85_RS09490	COG1766	The M ring may be actively involved in energy transduction
CRG85_RS09505	COG2076	Multidrug Resistance protein
CRG85_RS09510	COG1881	PFAM PEBP family protein
CRG85_RS09515	COG2207	Transcriptional regulator
CRG85_RS09530	COG0675	Transposase, IS605 OrfB family
CRG85_RS09535	COG2135	peptidase activity
CRG85_RS09540	COG0425	Belongs to the sulfur carrier protein TusA family
CRG85_RS09545	COG2391	methyltransferase activity
CRG85_RS09555	COG0366	Alpha amylase catalytic
CRG85_RS09565	COG1516	flagellar protein fliS
CRG85_RS09570	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CRG85_RS09575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRG85_RS09580	COG1191	sigma factor activity
CRG85_RS09590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS09600	COG0765	amino acid transport
CRG85_RS09605	COG1126	abc transporter atp-binding protein
CRG85_RS09610	COG2197	response regulator
CRG85_RS09625	COG2197	response regulator
CRG85_RS09655	COG3318	Belongs to the UPF0149 family
CRG85_RS09655	COG3012	SEC-C Motif Domain Protein
CRG85_RS09660	COG0814	amino acid
CRG85_RS09670	COG1528	Iron-storage protein
CRG85_RS09690	COG1528	Iron-storage protein
CRG85_RS09695	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS09700	COG1129	ABC transporter
CRG85_RS09705	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS09710	COG1877	trehalose-phosphatase activity
CRG85_RS09720	COG0589	response to stress
CRG85_RS09735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CRG85_RS09740	COG1360	Flagellar Motor Protein
CRG85_RS09745	COG2198	Histidine kinase
CRG85_RS09745	COG0643	Histidine kinase
CRG85_RS09750	COG0835	chemotaxis
CRG85_RS09755	COG0840	transmembrane signaling receptor activity
CRG85_RS09760	COG0840	transmembrane signaling receptor activity
CRG85_RS09765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRG85_RS09775	COG0745	RESPONSE REGULATOR receiver
CRG85_RS09780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CRG85_RS09785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRG85_RS09790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRG85_RS09800	COG3755	Protein conserved in bacteria
CRG85_RS09810	COG3102	Protein conserved in bacteria
CRG85_RS09820	COG3005	denitrification pathway
CRG85_RS09825	COG0243	molybdopterin cofactor binding
CRG85_RS09840	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CRG85_RS09845	COG1801	Protein of unknown function DUF72
CRG85_RS09910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CRG85_RS09915	COG1801	Protein of unknown function DUF72
CRG85_RS09920	COG1335	isochorismatase
CRG85_RS09930	COG0494	nUDIX hydrolase
CRG85_RS09935	COG0217	transcriptional regulatory protein
CRG85_RS09960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRG85_RS09970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CRG85_RS09975	COG0739	heme binding
CRG85_RS09980	COG1560	Kdo2-lipid A biosynthetic process
CRG85_RS09985	COG0469	pyruvate kinase activity
CRG85_RS09990	COG1737	Transcriptional regulator
CRG85_RS09995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CRG85_RS10000	COG0129	dihydroxy-acid dehydratase activity
CRG85_RS10005	COG0800	Aldolase
CRG85_RS10015	COG3141	response to X-ray
CRG85_RS10025	COG2979	Protein of unknown function (DUF533)
CRG85_RS10030	COG1770	oligopeptidase
CRG85_RS10035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRG85_RS10040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRG85_RS10050	COG2372	response to copper ion
CRG85_RS10055	COG1276	copper resistance
CRG85_RS10065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRG85_RS10085	COG3008	intermembrane lipid transfer
CRG85_RS10090	COG2995	paraquat-inducible protein a
CRG85_RS10095	COG1956	GAF domain-containing protein
CRG85_RS10105	COG0793	Belongs to the peptidase S41A family
CRG85_RS10115	COG2814	Major facilitator Superfamily
CRG85_RS10120	COG1414	Transcriptional regulator
CRG85_RS10150	COG2226	methyltransferase
CRG85_RS10165	COG3716	PTS system mannose fructose sorbose family IID component
CRG85_RS10170	COG3715	PTS system
CRG85_RS10175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS10175	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS10180	COG1253	flavin adenine dinucleotide binding
CRG85_RS10185	COG2200	EAL domain
CRG85_RS10190	COG1760	l-serine dehydratase
CRG85_RS10200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRG85_RS10215	COG0251	oxidation-reduction process
CRG85_RS10220	COG1199	ATP-dependent helicase activity
CRG85_RS10225	COG1214	PFAM Peptidase M22, glycoprotease
CRG85_RS10230	COG3065	identical protein binding
CRG85_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
CRG85_RS10240	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CRG85_RS10245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG85_RS10250	COG4638	Rieske (2fe-2S)
CRG85_RS10255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CRG85_RS10260	COG0473	3-isopropylmalate dehydrogenase activity
CRG85_RS10265	COG0583	DNA-binding transcription factor activity
CRG85_RS10275	COG3615	Tellurite resistance protein tehB
CRG85_RS10285	COG2261	transglycosylase associated protein
CRG85_RS10300	COG2199	diguanylate cyclase activity
CRG85_RS10300	COG2203	Gaf domain
CRG85_RS10305	COG3042	response to heat
CRG85_RS10310	COG3189	MarR family transcriptional regulator
CRG85_RS10315	COG2807	transmembrane transport
CRG85_RS10320	COG2207	Transcriptional regulator
CRG85_RS10335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRG85_RS10340	COG2199	diguanylate cyclase activity
CRG85_RS10345	COG2199	diguanylate cyclase activity
CRG85_RS10355	COG2766	serine protein kinase
CRG85_RS10360	COG3713	MltA-interacting MipA family protein
CRG85_RS10365	COG0656	L-ascorbic acid biosynthetic process
CRG85_RS10370	COG0676	glucose-6-phosphate 1-epimerase activity
CRG85_RS10375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRG85_RS10385	COG3139	Protein of unknown function (DUF1315)
CRG85_RS10390	COG1063	alcohol dehydrogenase
CRG85_RS10395	COG2271	Major facilitator Superfamily
CRG85_RS10405	COG0191	fructose-bisphosphate aldolase activity
CRG85_RS10410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS10415	COG0667	Aldo Keto reductase
CRG85_RS10420	COG1349	DNA-binding transcription factor activity
CRG85_RS10425	COG2814	Major facilitator Superfamily
CRG85_RS10430	COG1335	isochorismatase
CRG85_RS10435	COG0252	asparaginase activity
CRG85_RS10440	COG0616	signal peptide processing
CRG85_RS10445	COG0778	Nitroreductase
CRG85_RS10455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRG85_RS10470	COG3547	Transposase (IS116 IS110 IS902 family)
CRG85_RS10480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CRG85_RS10490	COG0494	nUDIX hydrolase
CRG85_RS10495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRG85_RS10500	COG2897	thiosulfate sulfurtransferase activity
CRG85_RS10505	COG4136	ATPase activity
CRG85_RS10510	COG4135	transport system, permease component
CRG85_RS10515	COG4134	Bacterial extracellular solute-binding protein
CRG85_RS10520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRG85_RS10525	COG0398	Pfam SNARE associated Golgi protein
CRG85_RS10535	COG0398	Pfam SNARE associated Golgi protein
CRG85_RS10540	COG0708	Exodeoxyribonuclease III
CRG85_RS10570	COG3678	ATP-independent chaperone mediated protein folding
CRG85_RS10580	COG0322	excinuclease ABC activity
CRG85_RS10590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRG85_RS10600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRG85_RS10605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRG85_RS10610	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRG85_RS10615	COG1917	Cupin 2, conserved barrel domain protein
CRG85_RS10615	COG2169	Transcriptional regulator
CRG85_RS10620	COG1486	melibiose metabolic process
CRG85_RS10630	COG0753	catalase activity
CRG85_RS10645	COG1823	symporter activity
CRG85_RS10650	COG1988	membrane-bound metal-dependent
CRG85_RS10655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRG85_RS10665	COG3001	Fructosamine kinase
CRG85_RS10675	COG1105	Belongs to the carbohydrate kinase PfkB family
CRG85_RS10680	COG3137	Salt-induced outer membrane protein
CRG85_RS10725	COG0072	phenylalanine-tRNA ligase activity
CRG85_RS10725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRG85_RS10740	COG0386	Belongs to the glutathione peroxidase family
CRG85_RS10750	COG0791	NLP P60 protein
CRG85_RS10755	COG2200	EAL domain
CRG85_RS10765	COG4256	Hemin uptake protein
CRG85_RS10770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRG85_RS10780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRG85_RS10780	COG0574	Belongs to the PEP-utilizing enzyme family
CRG85_RS10785	COG0318	PFAM AMP-dependent synthetase and ligase
CRG85_RS10790	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CRG85_RS10795	COG0644	oxidoreductase
CRG85_RS10800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRG85_RS10805	COG2086	electron transfer activity
CRG85_RS10810	COG1917	Cupin 2, conserved barrel domain protein
CRG85_RS10810	COG2207	Transcriptional regulator
CRG85_RS10815	COG1960	acyl-CoA dehydrogenase activity
CRG85_RS10820	COG4670	ketone body catabolic process
CRG85_RS10835	COG2271	Major facilitator Superfamily
CRG85_RS10840	COG0738	Major facilitator superfamily
CRG85_RS10855	COG0628	permease
CRG85_RS10860	COG0277	FAD linked oxidase domain protein
CRG85_RS10860	COG0247	lactate metabolic process
CRG85_RS10865	COG2050	protein possibly involved in aromatic compounds catabolism
CRG85_RS10875	COG0316	Belongs to the HesB IscA family
CRG85_RS10880	COG0719	Fe-S assembly protein
CRG85_RS10885	COG0396	ATPase activity
CRG85_RS10890	COG0719	Fe-S assembly protein
CRG85_RS10905	COG1376	ErfK ybiS ycfS ynhG family protein
CRG85_RS10910	COG4238	major outer membrane lipoprotein
CRG85_RS10915	COG0469	pyruvate kinase activity
CRG85_RS10925	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS10930	COG2414	aldehyde ferredoxin oxidoreductase
CRG85_RS10940	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS10945	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CRG85_RS10955	COG4529	Protein conserved in bacteria
CRG85_RS10975	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS10985	COG0307	riboflavin synthase, alpha
CRG85_RS10990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRG85_RS10995	COG2814	Major facilitator Superfamily
CRG85_RS11000	COG0583	DNA-binding transcription factor activity
CRG85_RS11015	COG2814	Major facilitator Superfamily
CRG85_RS11020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRG85_RS11025	COG0791	NLP P60 protein
CRG85_RS11030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CRG85_RS11045	COG0346	lactoylglutathione lyase activity
CRG85_RS11050	COG1902	pentaerythritol trinitrate reductase activity
CRG85_RS11055	COG1309	transcriptional regulator
CRG85_RS11060	COG3313	Fe-S protein
CRG85_RS11065	COG4989	oxidoreductase activity
CRG85_RS11070	COG2032	superoxide dismutase activity
CRG85_RS11075	COG1289	transmembrane transporter activity
CRG85_RS11095	COG3133	Outer membrane lipoprotein
CRG85_RS11105	COG3895	Periplasmic Protein
CRG85_RS11120	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CRG85_RS11125	COG0625	glutathione transferase activity
CRG85_RS11130	COG3104	oligopeptide transport
CRG85_RS11135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRG85_RS11145	COG4659	FMN binding
CRG85_RS11185	COG0673	inositol 2-dehydrogenase activity
CRG85_RS11195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CRG85_RS11200	COG1263	PTS System
CRG85_RS11200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS11205	COG1609	Transcriptional regulator
CRG85_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS11215	COG1309	transcriptional regulator
CRG85_RS11220	COG3250	beta-galactosidase activity
CRG85_RS11235	COG5339	Protein conserved in bacteria
CRG85_RS11240	COG1482	cell wall glycoprotein biosynthetic process
CRG85_RS11245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRG85_RS11245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRG85_RS11250	COG0114	fumarate hydratase activity
CRG85_RS11260	COG2205	protein histidine kinase activity
CRG85_RS11265	COG0745	RESPONSE REGULATOR receiver
CRG85_RS11270	COG3136	membrane protein required for alginate biosynthesis
CRG85_RS11280	COG0531	amino acid
CRG85_RS11290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CRG85_RS11295	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CRG85_RS11300	COG0628	permease
CRG85_RS11320	COG3591	Belongs to the peptidase S1B family
CRG85_RS11335	COG2814	Major facilitator Superfamily
CRG85_RS11340	COG0583	DNA-binding transcription factor activity
CRG85_RS11345	COG1940	carbohydrate kinase activity
CRG85_RS11350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRG85_RS11360	COG3381	protein complex oligomerization
CRG85_RS11365	COG3302	dmso reductase anchor subunit
CRG85_RS11370	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS11375	COG0243	molybdopterin cofactor binding
CRG85_RS11395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRG85_RS11410	COG4948	Mandelate Racemase Muconate Lactonizing
CRG85_RS11420	COG0246	Mannitol dehydrogenase
CRG85_RS11430	COG1802	Transcriptional regulator
CRG85_RS11435	COG4221	oxidoreductase activity
CRG85_RS11440	COG0339	signal peptide processing
CRG85_RS11445	COG1546	Belongs to the CinA family
CRG85_RS11450	COG3111	PFAM Bacterial OB fold (BOF) protein
CRG85_RS11455	COG3706	GGDEF domain
CRG85_RS11470	COG0697	spore germination
CRG85_RS11475	COG2188	Transcriptional regulator
CRG85_RS11485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CRG85_RS11490	COG1447	Phosphotransferase system cellobiose-specific component IIA
CRG85_RS11500	COG2723	6-phospho-beta-galactosidase activity
CRG85_RS11510	COG4977	sequence-specific DNA binding
CRG85_RS11515	COG1846	Transcriptional regulator
CRG85_RS11540	COG0583	DNA-binding transcription factor activity
CRG85_RS11545	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS11550	COG2066	Belongs to the glutaminase family
CRG85_RS11560	COG2199	diguanylate cyclase activity
CRG85_RS11570	COG3781	membrane
CRG85_RS11615	COG1070	Carbohydrate kinase
CRG85_RS11625	COG1396	sequence-specific DNA binding
CRG85_RS11630	COG3550	peptidyl-serine autophosphorylation
CRG85_RS11645	COG3539	Fimbrial protein
CRG85_RS11650	COG3539	Fimbrial protein
CRG85_RS11655	COG3539	Fimbrial protein
CRG85_RS11660	COG0243	molybdopterin cofactor binding
CRG85_RS11675	COG3119	arylsulfatase activity
CRG85_RS11680	COG0641	radical SAM
CRG85_RS11690	COG4178	(ABC) transporter
CRG85_RS11695	COG4771	TonB-dependent receptor
CRG85_RS11700	COG0612	Peptidase, M16
CRG85_RS11705	COG0076	glutamate decarboxylase activity
CRG85_RS11710	COG0531	amino acid
CRG85_RS11715	COG1649	PFAM Uncharacterised BCR, COG1649
CRG85_RS11725	COG2199	diguanylate cyclase activity
CRG85_RS11725	COG2200	EAL domain
CRG85_RS11725	COG2202	Pas domain
CRG85_RS11730	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CRG85_RS11735	COG0747	negative chemotaxis
CRG85_RS11740	COG0601	transmembrane transport
CRG85_RS11745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRG85_RS11750	COG0444	Belongs to the ABC transporter superfamily
CRG85_RS11755	COG4608	Belongs to the ABC transporter superfamily
CRG85_RS11760	COG1764	response to oxidative stress
CRG85_RS11785	COG3093	addiction module antidote protein HigA
CRG85_RS11790	COG2864	formate dehydrogenase
CRG85_RS11795	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS11805	COG0697	spore germination
CRG85_RS11810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CRG85_RS11815	COG4886	Leucine-rich repeat (LRR) protein
CRG85_RS11820	COG4886	Leucine-rich repeat (LRR) protein
CRG85_RS11825	COG2223	nitrite transmembrane transporter activity
CRG85_RS11830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CRG85_RS11835	COG1140	nitrate reductase beta subunit
CRG85_RS11840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CRG85_RS11845	COG2181	nitrate reductase activity
CRG85_RS11855	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CRG85_RS11860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRG85_RS11915	COG0625	glutathione transferase activity
CRG85_RS11920	COG1113	amino acid transport
CRG85_RS11925	COG3391	amine dehydrogenase activity
CRG85_RS11930	COG4772	TonB-dependent receptor
CRG85_RS11935	COG1802	Transcriptional regulator
CRG85_RS11940	COG2130	NADP-dependent
CRG85_RS11945	COG1247	-acetyltransferase
CRG85_RS11950	COG3238	Protein conserved in bacteria
CRG85_RS11985	COG1177	transmembrane transport
CRG85_RS11990	COG1176	ABC-type spermidine putrescine transport system, permease component I
CRG85_RS11995	COG3842	ATPase activity
CRG85_RS12000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CRG85_RS12005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRG85_RS12010	COG1598	PFAM Uncharacterised protein family UPF0150
CRG85_RS12015	COG1724	mRNA binding
CRG85_RS12025	COG0826	peptidase U32
CRG85_RS12030	COG1396	sequence-specific DNA binding
CRG85_RS12035	COG3135	benzoate transporter
CRG85_RS12040	COG0675	Transposase, IS605 OrfB family
CRG85_RS12055	COG0500	methyltransferase
CRG85_RS12060	COG1275	C4-dicarboxylate transporter malic acid transport protein
CRG85_RS12065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CRG85_RS12070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRG85_RS12075	COG2841	Protein conserved in bacteria
CRG85_RS12085	COG5383	Protein conserved in bacteria
CRG85_RS12090	COG0583	DNA-binding transcription factor activity
CRG85_RS12095	COG0840	transmembrane signaling receptor activity
CRG85_RS12120	COG3038	cytochrome b561
CRG85_RS12125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRG85_RS12130	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS12135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CRG85_RS12140	COG1643	Atp-dependent helicase
CRG85_RS12150	COG0671	phosphoesterase, PA-phosphatase related
CRG85_RS12150	COG2453	phosphatase
CRG85_RS12155	COG2267	carboxylic ester hydrolase activity
CRG85_RS12160	COG4589	Belongs to the CDS family
CRG85_RS12165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRG85_RS12175	COG0667	Aldo Keto reductase
CRG85_RS12195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CRG85_RS12200	COG3327	negative regulation of DNA-templated transcription, initiation
CRG85_RS12210	COG0183	Belongs to the thiolase family
CRG85_RS12215	COG2050	protein possibly involved in aromatic compounds catabolism
CRG85_RS12220	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRG85_RS12225	COG1024	Enoyl-CoA hydratase
CRG85_RS12230	COG1024	Enoyl-CoA hydratase
CRG85_RS12235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG85_RS12240	COG2151	metal-sulfur cluster biosynthetic enzyme
CRG85_RS12245	COG3396	Phenylacetate-CoA oxygenase
CRG85_RS12250	COG3460	Phenylacetate-CoA oxygenase
CRG85_RS12255	COG3396	Phenylacetate-CoA oxygenase
CRG85_RS12260	COG2030	dehydratase
CRG85_RS12260	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS12265	COG3733	amine oxidase
CRG85_RS12270	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS12275	COG2207	Transcriptional regulator
CRG85_RS12280	COG3784	Protein of unknown function (DUF1318)
CRG85_RS12290	COG2911	Protein conserved in bacteria
CRG85_RS12295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRG85_RS12300	COG3187	Heat shock protein
CRG85_RS12305	COG3042	response to heat
CRG85_RS12310	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRG85_RS12310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG85_RS12310	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRG85_RS12310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRG85_RS12315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CRG85_RS12320	COG0589	response to stress
CRG85_RS12345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRG85_RS12360	COG3723	Recombinational DNA repair protein, rece pathway
CRG85_RS12380	COG0582	viral genome integration into host DNA
CRG85_RS12390	COG0513	Belongs to the DEAD box helicase family
CRG85_RS12400	COG3706	GGDEF domain
CRG85_RS12405	COG2840	Smr protein MutS2
CRG85_RS12410	COG0583	DNA-binding transcription factor activity
CRG85_RS12415	COG1473	amidohydrolase
CRG85_RS12425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CRG85_RS12430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRG85_RS12435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRG85_RS12440	COG0589	response to stress
CRG85_RS12445	COG3182	Iron-regulated membrane protein
CRG85_RS12450	COG0668	transmembrane transport
CRG85_RS12455	COG4166	transmembrane transport
CRG85_RS12460	COG0583	DNA-binding transcription factor activity
CRG85_RS12465	COG1073	alpha beta
CRG85_RS12480	COG2866	Carboxypeptidase
CRG85_RS12485	COG4948	Mandelate Racemase Muconate Lactonizing
CRG85_RS12490	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRG85_RS12495	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CRG85_RS12505	COG3106	COG3106 Predicted ATPase
CRG85_RS12510	COG1609	Transcriptional regulator
CRG85_RS12520	COG3842	ATPase activity
CRG85_RS12525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRG85_RS12530	COG1554	hydrolase, family 65, central catalytic
CRG85_RS12535	COG0673	inositol 2-dehydrogenase activity
CRG85_RS12540	COG1082	Xylose isomerase domain protein TIM barrel
CRG85_RS12545	COG1063	alcohol dehydrogenase
CRG85_RS12550	COG0395	ABC-type sugar transport system, permease component
CRG85_RS12555	COG1175	transmembrane transport
CRG85_RS12560	COG1653	transport
CRG85_RS12565	COG0366	Alpha amylase catalytic
CRG85_RS12570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRG85_RS12580	COG1983	PspC domain protein
CRG85_RS12590	COG1842	Phage shock protein A
CRG85_RS12595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CRG85_RS12605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRG85_RS12610	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS12615	COG1917	Cupin 2, conserved barrel domain protein
CRG85_RS12615	COG1396	sequence-specific DNA binding
CRG85_RS12620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRG85_RS12625	COG0174	glutamine synthetase
CRG85_RS12635	COG0531	amino acid
CRG85_RS12645	COG4166	transmembrane transport
CRG85_RS12650	COG4168	peptide transport system, permease
CRG85_RS12655	COG4171	peptide transport system, permease
CRG85_RS12660	COG4172	Belongs to the ABC transporter superfamily
CRG85_RS12665	COG4172	Belongs to the ABC transporter superfamily
CRG85_RS12670	COG2852	Protein conserved in bacteria
CRG85_RS12675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRG85_RS12680	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRG85_RS12680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRG85_RS12695	COG5001	Diguanylate cyclase
CRG85_RS12705	COG1349	DNA-binding transcription factor activity
CRG85_RS12715	COG0023	Translation Initiation Factor
CRG85_RS12725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CRG85_RS12730	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CRG85_RS12735	COG0671	phosphoesterase, PA-phosphatase related
CRG85_RS12745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRG85_RS12765	COG0583	DNA-binding transcription factor activity
CRG85_RS12770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRG85_RS12780	COG0616	signal peptide processing
CRG85_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS12790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CRG85_RS12795	COG1187	pseudouridine synthase activity
CRG85_RS12800	COG4907	membrane protein (DUF2207)
CRG85_RS12805	COG0009	L-threonylcarbamoyladenylate synthase
CRG85_RS12810	COG0613	PHP domain protein
CRG85_RS12820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRG85_RS12825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRG85_RS12825	COG0512	Glutamine amidotransferase of anthranilate synthase
CRG85_RS12830	COG0134	indole-3-glycerol-phosphate synthase activity
CRG85_RS12830	COG0135	phosphoribosylanthranilate isomerase activity
CRG85_RS12845	COG3729	General stress protein
CRG85_RS12850	COG3685	Protein conserved in bacteria
CRG85_RS12855	COG3685	Protein conserved in bacteria
CRG85_RS12860	COG3047	cAMP biosynthetic process
CRG85_RS12880	COG1607	acyl-coa hydrolase
CRG85_RS12885	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CRG85_RS12890	COG2350	Protein conserved in bacteria
CRG85_RS12895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRG85_RS12915	COG4608	Belongs to the ABC transporter superfamily
CRG85_RS12920	COG0444	Belongs to the ABC transporter superfamily
CRG85_RS12925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRG85_RS12930	COG0601	transmembrane transport
CRG85_RS12935	COG4166	transmembrane transport
CRG85_RS12940	COG2095	MarC family integral membrane protein
CRG85_RS12945	COG1454	alcohol dehydrogenase
CRG85_RS12945	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS12950	COG1435	thymidine kinase activity
CRG85_RS12960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRG85_RS12965	COG0745	RESPONSE REGULATOR receiver
CRG85_RS12970	COG1752	Esterase of the alpha-beta hydrolase superfamily
CRG85_RS12980	COG0788	formyltetrahydrofolate deformylase activity
CRG85_RS13020	COG2181	nitrate reductase activity
CRG85_RS13025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CRG85_RS13030	COG1140	nitrate reductase beta subunit
CRG85_RS13035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CRG85_RS13040	COG2223	nitrite transmembrane transporter activity
CRG85_RS13045	COG3850	Histidine kinase
CRG85_RS13050	COG2197	response regulator
CRG85_RS13055	COG4932	domain protein
CRG85_RS13060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CRG85_RS13065	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CRG85_RS13070	COG4572	Cation transport regulator
CRG85_RS13075	COG0387	Pfam Sodium calcium exchanger
CRG85_RS13095	COG2912	Transglutaminase-like superfamily
CRG85_RS13100	COG3094	Invasion gene expression up-regulator, SirB
CRG85_RS13105	COG2890	protein-(glutamine-N5) methyltransferase activity
CRG85_RS13130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRG85_RS13135	COG0659	secondary active sulfate transmembrane transporter activity
CRG85_RS13150	COG0012	GTP binding
CRG85_RS13155	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS13160	COG3284	Transcriptional regulator
CRG85_RS13165	COG2376	Dihydroxyacetone kinase
CRG85_RS13170	COG1461	Dihydroxyacetone kinase
CRG85_RS13175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS13175	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CRG85_RS13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRG85_RS13195	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CRG85_RS13205	COG1619	proteins homologs of microcin C7 resistance protein MccF
CRG85_RS13220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRG85_RS13230	COG2719	SpoVR family
CRG85_RS13245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CRG85_RS13250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRG85_RS13255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRG85_RS13270	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRG85_RS13295	COG2894	cell division
CRG85_RS13340	COG2200	EAL domain
CRG85_RS13370	COG0789	Transcriptional regulator
CRG85_RS13375	COG5562	phage envelope protein
CRG85_RS13390	COG0538	isocitrate dehydrogenase activity
CRG85_RS13395	COG1187	pseudouridine synthase activity
CRG85_RS13415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRG85_RS13420	COG0745	RESPONSE REGULATOR receiver
CRG85_RS13425	COG2205	protein histidine kinase activity
CRG85_RS13430	COG2850	peptidyl-arginine hydroxylation
CRG85_RS13450	COG1177	transmembrane transport
CRG85_RS13455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CRG85_RS13465	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CRG85_RS13470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CRG85_RS13480	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRG85_RS13485	COG1136	(ABC) transporter
CRG85_RS13490	COG4591	ABC-type transport system involved in lipoprotein release permease component
CRG85_RS13495	COG4763	Acyl-transferase
CRG85_RS13500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRG85_RS13505	COG1388	LysM domain
CRG85_RS13505	COG1376	ErfK ybiS ycfS ynhG family protein
CRG85_RS13515	COG1309	transcriptional regulator
CRG85_RS13520	COG3134	Outer membrane lipoprotein
CRG85_RS13525	COG1252	NADH dehydrogenase
CRG85_RS13545	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CRG85_RS13550	COG5633	Lipoprotein
CRG85_RS13555	COG0537	adenosine 5'-monophosphoramidase activity
CRG85_RS13560	COG4773	Receptor
CRG85_RS13565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS13565	COG1263	PTS System
CRG85_RS13570	COG0084	hydrolase, TatD family'
CRG85_RS13575	COG0470	DNA polymerase III
CRG85_RS13585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CRG85_RS13590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRG85_RS13595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRG85_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS13610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CRG85_RS13630	COG1399	metal-binding, possibly nucleic acid-binding protein
CRG85_RS13635	COG0424	maF-like protein
CRG85_RS13640	COG0564	pseudouridine synthase activity
CRG85_RS13650	COG1530	ribonuclease E activity
CRG85_RS13655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRG85_RS13660	COG1256	bacterial-type flagellum assembly
CRG85_RS13665	COG3951	Flagellar rod assembly protein muramidase FlgJ
CRG85_RS13665	COG1705	Flagellar rod assembly protein muramidase FlgJ
CRG85_RS13680	COG4786	Flagellar basal body rod
CRG85_RS13685	COG4787	bacterial-type flagellum-dependent cell motility
CRG85_RS13690	COG1749	Flagellar hook protein flgE
CRG85_RS13695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CRG85_RS13700	COG1558	bacterial-type flagellum-dependent cell motility
CRG85_RS13705	COG1815	bacterial-type flagellum-dependent cell motility
CRG85_RS13710	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CRG85_RS13715	COG2747	anti-sigma28 factor FlgM
CRG85_RS13720	COG3418	PFAM FlgN family protein
CRG85_RS13725	COG0728	peptidoglycan biosynthetic process
CRG85_RS13730	COG0673	inositol 2-dehydrogenase activity
CRG85_RS13740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRG85_RS13750	COG2999	glutathione oxidoreductase activity
CRG85_RS13785	COG3038	cytochrome b561
CRG85_RS13790	COG2353	YceI-like domain
CRG85_RS13800	COG1560	Kdo2-lipid A biosynthetic process
CRG85_RS13815	COG5645	(Lipo)protein
CRG85_RS13820	COG2943	transferase activity, transferring hexosyl groups
CRG85_RS13835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRG85_RS13840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRG85_RS13865	COG2197	response regulator
CRG85_RS13880	COG1462	curli production assembly transport component CsgG
CRG85_RS13890	COG3381	protein complex oligomerization
CRG85_RS13915	COG3706	GGDEF domain
CRG85_RS13920	COG0457	Tetratricopeptide repeat
CRG85_RS13925	COG0726	polysaccharide deacetylase
CRG85_RS13925	COG1649	PFAM Uncharacterised BCR, COG1649
CRG85_RS13930	COG1215	transferase activity, transferring glycosyl groups
CRG85_RS13935	COG3658	cytochrome
CRG85_RS13940	COG1702	phosphate starvation-inducible protein PhoH
CRG85_RS13945	COG2837	iron assimilation
CRG85_RS13950	COG2822	iron ion transport
CRG85_RS13960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRG85_RS13970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRG85_RS13970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRG85_RS13970	COG0506	proline dehydrogenase activity
CRG85_RS13975	COG1309	transcriptional regulator
CRG85_RS13985	COG1335	isochorismatase
CRG85_RS14010	COG2233	PERMEase
CRG85_RS14015	COG3729	General stress protein
CRG85_RS14065	COG3005	denitrification pathway
CRG85_RS14070	COG0745	RESPONSE REGULATOR receiver
CRG85_RS14075	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS14080	COG0784	Response regulator, receiver
CRG85_RS14080	COG2205	protein histidine kinase activity
CRG85_RS14080	COG2198	Histidine kinase
CRG85_RS14085	COG0348	domain, Protein
CRG85_RS14105	COG1278	Cold shock
CRG85_RS14110	COG1278	Cold shock
CRG85_RS14130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRG85_RS14135	COG1596	polysaccharide export
CRG85_RS14140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRG85_RS14145	COG3206	protein involved in exopolysaccharide biosynthesis
CRG85_RS14145	COG0489	protein tyrosine kinase activity
CRG85_RS14160	COG1294	oxidase, subunit
CRG85_RS14165	COG1271	oxidase subunit
CRG85_RS14170	COG1773	rubredoxin
CRG85_RS14175	COG1999	signal sequence binding
CRG85_RS14180	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRG85_RS14185	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CRG85_RS14190	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CRG85_RS14195	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRG85_RS14205	COG0670	Belongs to the BI1 family
CRG85_RS14210	COG2920	part of a sulfur-relay system
CRG85_RS14215	COG1254	Belongs to the acylphosphatase family
CRG85_RS14230	COG1832	CoA-binding protein
CRG85_RS14245	COG0210	DNA helicase
CRG85_RS14250	COG3304	Inner membrane component domain
CRG85_RS14255	COG1289	transmembrane transporter activity
CRG85_RS14260	COG3070	regulator of competence-specific genes
CRG85_RS14280	COG1067	ATP-dependent peptidase activity
CRG85_RS14290	COG3130	regulation of translation
CRG85_RS14295	COG3009	Protein conserved in bacteria
CRG85_RS14300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRG85_RS14300	COG3008	intermembrane lipid transfer
CRG85_RS14305	COG2995	paraquat-inducible protein a
CRG85_RS14310	COG0488	(ABC) transporter
CRG85_RS14320	COG3217	Mosc domain protein beta barrel domain protein
CRG85_RS14320	COG0633	Ferredoxin
CRG85_RS14335	COG3121	Chaperone
CRG85_RS14340	COG3539	Fimbrial protein
CRG85_RS14345	COG3539	Fimbrial protein
CRG85_RS14350	COG3539	Fimbrial protein
CRG85_RS14355	COG3188	usher protein
CRG85_RS14360	COG3121	Chaperone
CRG85_RS14365	COG3539	Fimbrial protein
CRG85_RS14370	COG0431	NADPH-dependent FMN reductase
CRG85_RS14385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRG85_RS14390	COG1116	anion transmembrane transporter activity
CRG85_RS14395	COG0308	aminopeptidase N
CRG85_RS14415	COG1448	Aminotransferase
CRG85_RS14420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRG85_RS14425	COG3108	Peptidase M15
CRG85_RS14430	COG2989	Protein conserved in bacteria
CRG85_RS14440	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CRG85_RS14450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRG85_RS14455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CRG85_RS14460	COG3173	Aminoglycoside phosphotransferase
CRG85_RS14475	COG3214	Protein conserved in bacteria
CRG85_RS14480	COG1663	tetraacyldisaccharide 4'-kinase activity
CRG85_RS14485	COG1132	(ABC) transporter
CRG85_RS14490	COG2333	competence protein COMEC
CRG85_RS14490	COG0658	competence protein
CRG85_RS14500	COG0539	negative regulation of cytoplasmic translation
CRG85_RS14510	COG0501	Belongs to the peptidase M48B family
CRG85_RS14525	COG2323	membrane
CRG85_RS14530	COG1944	ATP diphosphatase activity
CRG85_RS14535	COG2116	formate transmembrane transporter activity
CRG85_RS14540	COG1882	Formate acetyltransferase
CRG85_RS14545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRG85_RS14550	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRG85_RS14555	COG0583	DNA-binding transcription factor activity
CRG85_RS14560	COG0531	amino acid
CRG85_RS14570	COG1335	isochorismatase
CRG85_RS14575	COG3302	dmso reductase anchor subunit
CRG85_RS14580	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS14585	COG0243	molybdopterin cofactor binding
CRG85_RS14595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRG85_RS14605	COG1178	ABC-type Fe3 transport system permease component
CRG85_RS14605	COG1674	ftsk spoiiie
CRG85_RS14610	COG1522	sequence-specific DNA binding
CRG85_RS14615	COG0492	ferredoxin-NADP+ reductase activity
CRG85_RS14620	COG4988	ABC transporter
CRG85_RS14625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CRG85_RS14680	COG2003	Belongs to the UPF0758 family
CRG85_RS14700	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS14725	COG3039	Transposase
CRG85_RS14780	COG2963	transposase activity
CRG85_RS14820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRG85_RS14870	COG0582	viral genome integration into host DNA
CRG85_RS14890	COG0542	response to heat
CRG85_RS14900	COG1278	Cold shock
CRG85_RS14905	COG1136	(ABC) transporter
CRG85_RS14905	COG0577	efflux transmembrane transporter activity
CRG85_RS14910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS14915	COG2990	Protein conserved in bacteria
CRG85_RS14920	COG3593	DNA synthesis involved in DNA repair
CRG85_RS14930	COG2431	L-lysine efflux transmembrane transporter activity
CRG85_RS14940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG85_RS14945	COG0028	Belongs to the TPP enzyme family
CRG85_RS14950	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CRG85_RS14955	COG0702	epimerase
CRG85_RS14960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRG85_RS14965	COG3023	N-Acetylmuramoyl-L-alanine amidase
CRG85_RS14980	COG1126	abc transporter atp-binding protein
CRG85_RS14985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS14990	COG4215	(ABC) transporter
CRG85_RS14995	COG4160	amino acid transport
CRG85_RS15000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS15015	COG1177	transmembrane transport
CRG85_RS15020	COG1176	ABC-type spermidine putrescine transport system, permease component I
CRG85_RS15025	COG3842	ATPase activity
CRG85_RS15030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CRG85_RS15055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRG85_RS15125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRG85_RS15165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CRG85_RS15180	COG3226	Transcriptional regulator
CRG85_RS15185	COG0738	Major facilitator superfamily
CRG85_RS15190	COG0561	phosphatase activity
CRG85_RS15200	COG2814	Major facilitator Superfamily
CRG85_RS15205	COG0671	phosphoesterase, PA-phosphatase related
CRG85_RS15210	COG1349	DNA-binding transcription factor activity
CRG85_RS15215	COG1686	Belongs to the peptidase S11 family
CRG85_RS15220	COG0625	glutathione transferase activity
CRG85_RS15225	COG2133	pyrroloquinoline quinone binding
CRG85_RS15240	COG2199	diguanylate cyclase activity
CRG85_RS15245	COG2200	EAL domain
CRG85_RS15250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRG85_RS15260	COG0747	negative chemotaxis
CRG85_RS15265	COG4172	Belongs to the ABC transporter superfamily
CRG85_RS15270	COG1446	asparaginase
CRG85_RS15275	COG0303	'Molybdopterin
CRG85_RS15280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CRG85_RS15285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRG85_RS15290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRG85_RS15295	COG1882	Formate acetyltransferase
CRG85_RS15300	COG0561	phosphatase activity
CRG85_RS15310	COG0488	(ABC) transporter
CRG85_RS15315	COG1376	ErfK ybiS ycfS ynhG family protein
CRG85_RS15320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRG85_RS15325	COG1321	iron dependent repressor
CRG85_RS15335	COG2194	sulfuric ester hydrolase activity
CRG85_RS15340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CRG85_RS15350	COG5006	permease, DMT superfamily
CRG85_RS15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS15365	COG0765	amino acid transport
CRG85_RS15370	COG1126	abc transporter atp-binding protein
CRG85_RS15375	COG0668	transmembrane transport
CRG85_RS15390	COG4774	siderophore transport
CRG85_RS15400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRG85_RS15410	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CRG85_RS15415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRG85_RS15420	COG1199	ATP-dependent helicase activity
CRG85_RS15425	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
CRG85_RS15430	COG0513	Belongs to the DEAD box helicase family
CRG85_RS15435	COG1309	transcriptional regulator
CRG85_RS15445	COG1131	(ABC) transporter
CRG85_RS15450	COG0842	Transport permease protein
CRG85_RS15455	COG0842	Transport permease protein
CRG85_RS15465	COG3568	Endonuclease Exonuclease Phosphatase
CRG85_RS15470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CRG85_RS15475	COG0392	lysyltransferase activity
CRG85_RS15480	COG0670	Belongs to the BI1 family
CRG85_RS15485	COG0670	Belongs to the BI1 family
CRG85_RS15490	COG0314	molybdopterin synthase activity
CRG85_RS15495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CRG85_RS15505	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRG85_RS15515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRG85_RS15525	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRG85_RS15530	COG2226	methyltransferase
CRG85_RS15545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRG85_RS15550	COG1881	PFAM PEBP family protein
CRG85_RS15555	COG4677	pectinesterase activity
CRG85_RS15560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRG85_RS15565	COG0471	metal ion transport
CRG85_RS15570	COG2828	Protein conserved in bacteria
CRG85_RS15575	COG0583	DNA-binding transcription factor activity
CRG85_RS15585	COG0561	phosphatase activity
CRG85_RS15590	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CRG85_RS15595	COG4149	molybdate abc transporter
CRG85_RS15600	COG0725	ABC transporter, periplasmic molybdate-binding protein
CRG85_RS15610	COG2005	Transcriptional regulator
CRG85_RS15610	COG3585	molybdate ion transport
CRG85_RS15615	COG1119	ATPase activity
CRG85_RS15620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRG85_RS15625	COG1085	galactose-1-phosphate uridylyltransferase
CRG85_RS15635	COG2017	converts alpha-aldose to the beta-anomer
CRG85_RS15645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRG85_RS15655	COG1230	cation diffusion facilitator family transporter
CRG85_RS15660	COG3201	nicotinamide mononucleotide transporter
CRG85_RS15705	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CRG85_RS15710	COG2885	chlorophyll binding
CRG85_RS15720	COG3064	Membrane
CRG85_RS15725	COG0848	biopolymer transport protein
CRG85_RS15730	COG0811	peptide transport
CRG85_RS15735	COG0824	Thioesterase
CRG85_RS15740	COG3790	cyd operon protein YbgE
CRG85_RS15745	COG4890	Cyd operon protein YbgT
CRG85_RS15750	COG1294	oxidase, subunit
CRG85_RS15755	COG1271	oxidase subunit
CRG85_RS15760	COG0383	alpha-mannosidase activity
CRG85_RS15765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS15765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS15765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS15770	COG2188	Transcriptional regulator
CRG85_RS15775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRG85_RS15785	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRG85_RS15790	COG0567	Dehydrogenase, E1 component
CRG85_RS15795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRG85_RS15800	COG1053	succinate dehydrogenase
CRG85_RS15805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CRG85_RS15810	COG2009	succinate dehydrogenase
CRG85_RS15820	COG0372	Belongs to the citrate synthase family
CRG85_RS15825	COG3539	Fimbrial protein
CRG85_RS15830	COG3188	usher protein
CRG85_RS15835	COG3121	Chaperone
CRG85_RS15840	COG3539	Fimbrial protein
CRG85_RS15845	COG3180	Ammonia monooxygenase
CRG85_RS15860	COG1984	allophanate hydrolase subunit 2
CRG85_RS15865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRG85_RS15870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRG85_RS15875	COG3104	oligopeptide transport
CRG85_RS15880	COG0415	Belongs to the DNA photolyase family
CRG85_RS15885	COG3272	Protein of unknown function (DUF1722)
CRG85_RS15920	COG3209	COG3209 Rhs family protein
CRG85_RS15970	COG2205	protein histidine kinase activity
CRG85_RS15975	COG0745	RESPONSE REGULATOR receiver
CRG85_RS15990	COG1982	Orn Lys Arg decarboxylase major
CRG85_RS15995	COG0531	amino acid
CRG85_RS16015	COG0033	Phosphoglucomutase
CRG85_RS16020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CRG85_RS16025	COG0596	Alpha beta hydrolase
CRG85_RS16035	COG0716	FMN binding
CRG85_RS16045	COG0735	belongs to the Fur family
CRG85_RS16065	COG2190	(PTS) system
CRG85_RS16065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS16065	COG1263	PTS System
CRG85_RS16075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRG85_RS16080	COG1940	carbohydrate kinase activity
CRG85_RS16080	COG1846	Transcriptional regulator
CRG85_RS16085	COG0647	UMP catabolic process
CRG85_RS16095	COG3547	Transposase (IS116 IS110 IS902 family)
CRG85_RS16100	COG0367	asparagine synthase
CRG85_RS16140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRG85_RS16150	COG1702	phosphate starvation-inducible protein PhoH
CRG85_RS16160	COG4535	Mg2 and Co2 transporter CorC
CRG85_RS16165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CRG85_RS16170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRG85_RS16175	COG0765	amino acid transport
CRG85_RS16180	COG0765	amino acid transport
CRG85_RS16185	COG1126	abc transporter atp-binding protein
CRG85_RS16195	COG0443	Heat shock 70 kDa protein
CRG85_RS16200	COG2214	Heat shock protein DnaJ domain protein
CRG85_RS16210	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CRG85_RS16215	COG2214	Heat shock protein DnaJ domain protein
CRG85_RS16225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CRG85_RS16230	COG2888	peptidyl-tyrosine sulfation
CRG85_RS16245	COG1466	dna polymerase III delta subunit
CRG85_RS16255	COG0406	alpha-ribazole phosphatase activity
CRG85_RS16260	COG0799	negative regulation of ribosome biogenesis
CRG85_RS16270	COG0768	penicillin binding
CRG85_RS16275	COG0772	Belongs to the SEDS family
CRG85_RS16280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRG85_RS16285	COG1686	Belongs to the peptidase S11 family
CRG85_RS16300	COG0583	DNA-binding transcription factor activity
CRG85_RS16310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRG85_RS16315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRG85_RS16335	COG3069	C4-dicarboxylate transmembrane transporter activity
CRG85_RS16340	COG4565	transcriptional regulatory protein
CRG85_RS16345	COG3290	protein histidine kinase activity
CRG85_RS16350	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CRG85_RS16360	COG2301	Belongs to the HpcH HpaI aldolase family
CRG85_RS16365	COG3051	citrate lyase alpha subunit
CRG85_RS16380	COG0471	metal ion transport
CRG85_RS16385	COG3719	Belongs to the RNase T2 family
CRG85_RS16390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRG85_RS16395	COG1063	alcohol dehydrogenase
CRG85_RS16400	COG0589	response to stress
CRG85_RS16405	COG3634	alkyl hydroperoxide reductase activity
CRG85_RS16410	COG0450	alkyl hydroperoxide reductase
CRG85_RS16415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRG85_RS16420	COG0583	DNA-binding transcription factor activity
CRG85_RS16425	COG3969	phosphoadenosine phosphosulfate
CRG85_RS16430	COG1475	DNA binding
CRG85_RS16435	COG0436	Aminotransferase
CRG85_RS16440	COG0371	Dehydrogenase
CRG85_RS16445	COG2879	small protein
CRG85_RS16450	COG1966	Carbon starvation protein
CRG85_RS16455	COG2050	protein possibly involved in aromatic compounds catabolism
CRG85_RS16460	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS16465	COG1535	isochorismatase
CRG85_RS16465	COG3433	isochorismatase activity
CRG85_RS16470	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRG85_RS16475	COG1169	isochorismate synthase
CRG85_RS16480	COG4592	Periplasmic binding protein
CRG85_RS16490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRG85_RS16495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRG85_RS16500	COG1120	ATPase activity
CRG85_RS16505	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CRG85_RS16510	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CRG85_RS16510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRG85_RS16515	COG3251	PFAM MbtH domain protein
CRG85_RS16520	COG2382	esterase
CRG85_RS16525	COG4771	TonB-dependent receptor
CRG85_RS16530	COG2977	Belongs to the P-Pant transferase superfamily
CRG85_RS16535	COG3385	transposase activity
CRG85_RS16560	COG2315	Protein conserved in bacteria
CRG85_RS16565	COG0778	Nitroreductase
CRG85_RS16570	COG0668	transmembrane transport
CRG85_RS16575	COG1113	amino acid transport
CRG85_RS16580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRG85_RS16585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS16590	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS16595	COG1538	Outer membrane efflux protein
CRG85_RS16600	COG0745	RESPONSE REGULATOR receiver
CRG85_RS16605	COG5002	protein histidine kinase activity
CRG85_RS16630	COG4571	Outer membrane protease
CRG85_RS16635	COG2207	Transcriptional regulator
CRG85_RS16645	COG0500	methyltransferase
CRG85_RS16655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRG85_RS16675	COG5562	phage envelope protein
CRG85_RS16685	COG2801	Transposase and inactivated derivatives
CRG85_RS16690	COG0582	viral genome integration into host DNA
CRG85_RS16700	COG2197	response regulator
CRG85_RS16705	COG3539	Fimbrial protein
CRG85_RS16710	COG3539	Fimbrial protein
CRG85_RS16715	COG3188	usher protein
CRG85_RS16720	COG3121	Chaperone
CRG85_RS16725	COG3539	Fimbrial protein
CRG85_RS16735	COG2501	S4 domain
CRG85_RS16740	COG1988	membrane-bound metal-dependent
CRG85_RS16750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRG85_RS16760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRG85_RS16765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CRG85_RS16770	COG0549	Belongs to the carbamate kinase family
CRG85_RS16780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRG85_RS16785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRG85_RS16790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CRG85_RS16795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRG85_RS16800	COG3257	ureidoglycine aminohydrolase activity
CRG85_RS16805	COG1929	Belongs to the glycerate kinase type-1 family
CRG85_RS16810	COG2233	PERMEase
CRG85_RS16820	COG1953	Uracil, thiamine, allantoin
CRG85_RS16825	COG2084	Dehydrogenase
CRG85_RS16830	COG3622	Belongs to the hyi family
CRG85_RS16835	COG3960	tartronate-semialdehyde synthase activity
CRG85_RS16840	COG1414	Transcriptional regulator
CRG85_RS16850	COG0583	DNA-binding transcription factor activity
CRG85_RS16880	COG3209	COG3209 Rhs family protein
CRG85_RS16885	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CRG85_RS16890	COG4181	ATPase activity
CRG85_RS16895	COG2755	lipolytic protein G-D-S-L family
CRG85_RS16900	COG0300	oxidoreductase activity
CRG85_RS16905	COG3118	belongs to the thioredoxin family
CRG85_RS16910	COG0390	transport system, permease component
CRG85_RS16915	COG4619	ABC transporter
CRG85_RS16920	COG0330	HflC and HflK could
CRG85_RS16925	COG1585	Membrane protein implicated in regulation of membrane protease activity
CRG85_RS16930	COG0789	Transcriptional regulator
CRG85_RS16935	COG0531	amino acid
CRG85_RS16940	COG2066	Belongs to the glutaminase family
CRG85_RS16945	COG2217	Heavy metal translocating P-type atpase
CRG85_RS16950	COG3093	addiction module antidote protein HigA
CRG85_RS16960	COG3735	TraB family
CRG85_RS16965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRG85_RS16970	COG0737	Belongs to the 5'-nucleotidase family
CRG85_RS16975	COG2223	nitrite transmembrane transporter activity
CRG85_RS16980	COG4651	solute:proton antiporter activity
CRG85_RS16980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRG85_RS16985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS17020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CRG85_RS17030	COG2832	Protein of unknown function (DUF454)
CRG85_RS17035	COG3923	Primosomal replication protein n
CRG85_RS17045	COG1196	nuclear chromosome segregation
CRG85_RS17045	COG3264	Mechanosensitive ion channel
CRG85_RS17050	COG1309	transcriptional regulator
CRG85_RS17055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRG85_RS17060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRG85_RS17075	COG0110	maltose O-acetyltransferase activity
CRG85_RS17085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CRG85_RS17090	COG5507	3-demethylubiquinone-9 3-methyltransferase
CRG85_RS17100	COG3695	enzyme binding
CRG85_RS17105	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CRG85_RS17110	COG1946	Acyl-CoA thioesterase
CRG85_RS17115	COG0004	ammonium transporteR
CRG85_RS17120	COG0347	Belongs to the P(II) protein family
CRG85_RS17125	COG1132	(ABC) transporter
CRG85_RS17130	COG1132	(ABC) transporter
CRG85_RS17135	COG1522	sequence-specific DNA binding
CRG85_RS17145	COG4533	DNA binding
CRG85_RS17155	COG0824	Thioesterase
CRG85_RS17160	COG1555	photosystem II stabilization
CRG85_RS17165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRG85_RS17170	COG0776	regulation of translation
CRG85_RS17175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CRG85_RS17195	COG0271	Belongs to the BolA IbaG family
CRG85_RS17200	COG3056	Lipoprotein
CRG85_RS17205	COG2223	nitrite transmembrane transporter activity
CRG85_RS17210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CRG85_RS17215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRG85_RS17220	COG1845	cytochrome c oxidase, subunit III
CRG85_RS17225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CRG85_RS17250	COG2814	Major facilitator Superfamily
CRG85_RS17260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CRG85_RS17265	COG0693	protein deglycase activity
CRG85_RS17280	COG0142	geranyltranstransferase activity
CRG85_RS17290	COG0667	Aldo Keto reductase
CRG85_RS17295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CRG85_RS17300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CRG85_RS17315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRG85_RS17315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRG85_RS17325	COG4238	major outer membrane lipoprotein
CRG85_RS17330	COG3248	Nucleoside-binding outer membrane protein
CRG85_RS17335	COG1403	HNH endonuclease
CRG85_RS17340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRG85_RS17345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRG85_RS17350	COG1862	Preprotein translocase
CRG85_RS17370	COG0366	Alpha amylase catalytic
CRG85_RS17375	COG1113	amino acid transport
CRG85_RS17380	COG1114	Component of the transport system for branched-chain amino acids
CRG85_RS17385	COG5002	protein histidine kinase activity
CRG85_RS17390	COG0745	RESPONSE REGULATOR receiver
CRG85_RS17395	COG0420	3'-5' exonuclease activity
CRG85_RS17400	COG0419	ATPase involved in DNA repair
CRG85_RS17405	COG2814	Major facilitator Superfamily
CRG85_RS17410	COG1940	carbohydrate kinase activity
CRG85_RS17435	COG4126	flavin adenine dinucleotide binding
CRG85_RS17455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRG85_RS17460	COG3706	GGDEF domain
CRG85_RS17470	COG1785	Belongs to the alkaline phosphatase family
CRG85_RS17480	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRG85_RS17500	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CRG85_RS17505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRG85_RS17510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRG85_RS17515	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS17520	COG0113	porphobilinogen synthase activity
CRG85_RS17525	COG2175	clavaminate synthase activity
CRG85_RS17530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRG85_RS17535	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CRG85_RS17540	COG4521	taurine ABC transporter
CRG85_RS17545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRG85_RS17550	COG1215	transferase activity, transferring glycosyl groups
CRG85_RS17580	COG3122	Protein conserved in bacteria
CRG85_RS17585	COG2814	Major facilitator Superfamily
CRG85_RS17620	COG1414	Transcriptional regulator
CRG85_RS17625	COG1609	Transcriptional regulator
CRG85_RS17630	COG3250	beta-galactosidase activity
CRG85_RS17635	COG2223	nitrite transmembrane transporter activity
CRG85_RS17640	COG0110	maltose O-acetyltransferase activity
CRG85_RS17645	COG2807	transmembrane transport
CRG85_RS17655	COG0288	reversible hydration of carbon dioxide
CRG85_RS17660	COG0583	DNA-binding transcription factor activity
CRG85_RS17670	COG3547	Transposase (IS116 IS110 IS902 family)
CRG85_RS17675	COG0402	S-adenosylhomocysteine deaminase activity
CRG85_RS17680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CRG85_RS17685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRG85_RS17690	COG2079	MmgE PrpD family protein
CRG85_RS17695	COG0372	Belongs to the citrate synthase family
CRG85_RS17700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CRG85_RS17705	COG3829	transcription factor binding
CRG85_RS17715	COG1280	lysine exporter protein (LysE YggA)
CRG85_RS17730	COG1064	alcohol dehydrogenase
CRG85_RS17735	COG0402	S-adenosylhomocysteine deaminase activity
CRG85_RS17740	COG0549	Belongs to the carbamate kinase family
CRG85_RS17750	COG1304	FMN binding
CRG85_RS17755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRG85_RS17765	COG0666	response to abiotic stimulus
CRG85_RS17775	COG0583	DNA-binding transcription factor activity
CRG85_RS17780	COG2200	EAL domain
CRG85_RS17780	COG2771	luxR family
CRG85_RS17790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CRG85_RS17815	COG1556	Lactate utilization protein
CRG85_RS17820	COG1139	Iron-sulfur cluster binding protein
CRG85_RS17825	COG0247	lactate metabolic process
CRG85_RS17830	COG2207	Transcriptional regulator
CRG85_RS17835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRG85_RS17845	COG3059	membrane
CRG85_RS17855	COG3708	Transcriptional regulator
CRG85_RS17855	COG2207	Transcriptional regulator
CRG85_RS17860	COG1388	LysM domain
CRG85_RS17915	COG3121	Chaperone
CRG85_RS17920	COG0727	PFAM Uncharacterised protein family (UPF0153)
CRG85_RS17925	COG3477	response to acidic pH
CRG85_RS17935	COG2080	2 iron, 2 sulfur cluster binding
CRG85_RS17940	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CRG85_RS17945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRG85_RS17950	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CRG85_RS17955	COG0583	DNA-binding transcription factor activity
CRG85_RS17995	COG2003	Belongs to the UPF0758 family
CRG85_RS18015	COG3468	outer membrane autotransporter barrel domain protein
CRG85_RS18050	COG1874	Beta-galactosidase
CRG85_RS18055	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CRG85_RS18060	COG3833	ABC-type maltose transport systems, permease component
CRG85_RS18065	COG1175	transmembrane transport
CRG85_RS18070	COG2182	Extracellular solute-binding protein
CRG85_RS18150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CRG85_RS18170	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRG85_RS18175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CRG85_RS18180	COG1690	Belongs to the RtcB family
CRG85_RS18185	COG0454	-acetyltransferase
CRG85_RS18195	COG2161	toxin-antitoxin pair type II binding
CRG85_RS18215	COG1943	Transposase
CRG85_RS18220	COG0791	NLP P60 protein
CRG85_RS18225	COG3077	Addiction module antitoxin, RelB DinJ family
CRG85_RS18230	COG3041	Addiction module toxin RelE StbE family
CRG85_RS18235	COG3034	peptidoglycan biosynthetic process
CRG85_RS18240	COG0121	glutamine amidotransferase
CRG85_RS18250	COG1960	acyl-CoA dehydrogenase activity
CRG85_RS18260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRG85_RS18265	COG5433	transposase activity
CRG85_RS18325	COG3157	Type VI secretion system effector, Hcp
CRG85_RS18330	COG4104	PAAR repeat-containing protein
CRG85_RS18350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CRG85_RS18360	COG2226	methyltransferase
CRG85_RS18370	COG1388	LysM domain
CRG85_RS18370	COG0741	lytic transglycosylase activity
CRG85_RS18375	COG2226	methyltransferase
CRG85_RS18385	COG0583	DNA-binding transcription factor activity
CRG85_RS18390	COG0656	L-ascorbic acid biosynthetic process
CRG85_RS18425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRG85_RS18430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRG85_RS18435	COG2011	ABC-type metal ion transport system permease component
CRG85_RS18440	COG1464	Belongs to the NlpA lipoprotein family
CRG85_RS18450	COG1720	tRNA m6t6A37 methyltransferase activity
CRG85_RS18460	COG0791	NLP P60 protein
CRG85_RS18465	COG3015	lipoprotein NlpE involved in copper resistance
CRG85_RS18470	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CRG85_RS18475	COG4681	YaeQ
CRG85_RS18485	COG4568	rho-dependent transcription termination
CRG85_RS18490	COG0037	tRNA processing
CRG85_RS18495	COG0346	lactoylglutathione lyase activity
CRG85_RS18500	COG1982	Orn Lys Arg decarboxylase major
CRG85_RS18510	COG0587	DNA-directed DNA polymerase activity
CRG85_RS18535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRG85_RS18540	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CRG85_RS18550	COG0750	zinc metalloprotease
CRG85_RS18555	COG0575	Belongs to the CDS family
CRG85_RS18560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRG85_RS18565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CRG85_RS18590	COG0024	Methionine aminopeptidase
CRG85_RS18605	COG1408	metallophosphoesterase
CRG85_RS18620	COG3835	regulator
CRG85_RS18625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRG85_RS18640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRG85_RS18645	COG2860	membrane
CRG85_RS18670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRG85_RS18675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRG85_RS18680	COG1120	ATPase activity
CRG85_RS18685	COG4774	siderophore transport
CRG85_RS18690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRG85_RS18695	COG1643	Atp-dependent helicase
CRG85_RS18700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CRG85_RS18710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRG85_RS18720	COG0617	tRNA 3'-terminal CCA addition
CRG85_RS18725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CRG85_RS18730	COG3539	Fimbrial protein
CRG85_RS18735	COG3121	Chaperone
CRG85_RS18740	COG3188	usher protein
CRG85_RS18745	COG3539	Fimbrial protein
CRG85_RS18750	COG3539	Fimbrial protein
CRG85_RS18755	COG3539	Fimbrial protein
CRG85_RS18760	COG3539	Fimbrial protein
CRG85_RS18775	COG5464	transposase or invertase
CRG85_RS18785	COG0726	polysaccharide deacetylase
CRG85_RS18790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS18795	COG0842	Transport permease protein
CRG85_RS18800	COG1131	(ABC) transporter
CRG85_RS18805	COG0288	reversible hydration of carbon dioxide
CRG85_RS18810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CRG85_RS18815	COG4993	Dehydrogenase
CRG85_RS18820	COG2132	Multicopper oxidase
CRG85_RS18845	COG1049	propionate catabolic process, 2-methylcitrate cycle
CRG85_RS18850	COG3064	Membrane
CRG85_RS18855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRG85_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRG85_RS18865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CRG85_RS18870	COG2186	Transcriptional regulator
CRG85_RS18875	COG1113	amino acid transport
CRG85_RS18880	COG3725	Membrane protein required for beta-lactamase induction
CRG85_RS18885	COG3023	N-Acetylmuramoyl-L-alanine amidase
CRG85_RS18890	COG0157	Belongs to the NadC ModD family
CRG85_RS18895	COG4969	Belongs to the N-Me-Phe pilin family
CRG85_RS18900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRG85_RS18905	COG1459	type II secretion system
CRG85_RS18915	COG0237	dephospho-CoA kinase activity
CRG85_RS18930	COG0494	nUDIX hydrolase
CRG85_RS18950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRG85_RS18955	COG0849	cell division
CRG85_RS18960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CRG85_RS18965	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRG85_RS18980	COG0772	Belongs to the SEDS family
CRG85_RS18985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRG85_RS18995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRG85_RS19000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRG85_RS19005	COG0768	penicillin binding
CRG85_RS19010	COG3116	cell division
CRG85_RS19020	COG2001	Belongs to the MraZ family
CRG85_RS19025	COG1609	Transcriptional regulator
CRG85_RS19035	COG0440	acetolactate synthase activity
CRG85_RS19040	COG0028	Belongs to the TPP enzyme family
CRG85_RS19050	COG0583	DNA-binding transcription factor activity
CRG85_RS19065	COG0473	3-isopropylmalate dehydrogenase activity
CRG85_RS19080	COG2814	Major facilitator Superfamily
CRG85_RS19095	COG4143	(ABC) transporter
CRG85_RS19100	COG1178	ABC-type Fe3 transport system permease component
CRG85_RS19110	COG0586	Pfam SNARE associated Golgi protein
CRG85_RS19115	COG4977	sequence-specific DNA binding
CRG85_RS19130	COG0235	Class ii aldolase
CRG85_RS19135	COG0417	DNA replication proofreading
CRG85_RS19145	COG0564	pseudouridine synthase activity
CRG85_RS19150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CRG85_RS19155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRG85_RS19160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRG85_RS19185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRG85_RS19200	COG2271	Major facilitator Superfamily
CRG85_RS19205	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CRG85_RS19210	COG0644	oxidoreductase
CRG85_RS19260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CRG85_RS19265	COG0505	Belongs to the CarA family
CRG85_RS19285	COG1047	Peptidyl-prolyl cis-trans
CRG85_RS19300	COG0196	riboflavin kinase activity
CRG85_RS19330	COG0583	DNA-binding transcription factor activity
CRG85_RS19345	COG3385	transposase activity
CRG85_RS19365	COG4735	regulation of single-species biofilm formation
CRG85_RS19370	COG1584	GPR1 FUN34 yaaH family protein
CRG85_RS19375	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRG85_RS19380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRG85_RS19385	COG1115	amino acid carrier protein
CRG85_RS19400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRG85_RS19410	COG0460	homoserine dehydrogenase
CRG85_RS19410	COG0527	aspartate kinase activity
CRG85_RS19420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CRG85_RS19430	COG0745	RESPONSE REGULATOR receiver
CRG85_RS19435	COG4452	Inner membrane protein CreD
CRG85_RS19440	COG2205	protein histidine kinase activity
CRG85_RS19445	COG0745	RESPONSE REGULATOR receiver
CRG85_RS19450	COG3045	CreA protein
CRG85_RS19455	COG3708	Transcriptional regulator
CRG85_RS19455	COG2207	Transcriptional regulator
CRG85_RS19475	COG0741	lytic transglycosylase activity
CRG85_RS19480	COG0488	(ABC) transporter
CRG85_RS19485	COG3172	ATPase kinase involved in NAD metabolism
CRG85_RS19485	COG1056	cytidyltransferase-related domain
CRG85_RS19490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CRG85_RS19495	COG0560	Phosphoserine phosphatase
CRG85_RS19500	COG3726	membrane protein affecting hemolysin expression
CRG85_RS19535	COG1328	CTP reductase activity
CRG85_RS19540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRG85_RS19545	COG0084	hydrolase, TatD family'
CRG85_RS19550	COG4667	esterase of the alpha-beta hydrolase superfamily
CRG85_RS19560	COG2823	Periplasmic or secreted lipoprotein
CRG85_RS19570	COG1011	Hydrolase
CRG85_RS19575	COG0456	acetyltransferase
CRG85_RS19580	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CRG85_RS19610	COG4114	ferric iron reductase
CRG85_RS19615	COG2197	response regulator
CRG85_RS19620	COG2197	response regulator
CRG85_RS19625	COG2966	Psort location CytoplasmicMembrane, score
CRG85_RS19640	COG1484	DNA-dependent DNA replication
CRG85_RS19655	COG1063	alcohol dehydrogenase
CRG85_RS19660	COG1802	Transcriptional regulator
CRG85_RS19665	COG2271	Major facilitator Superfamily
CRG85_RS19670	COG0840	transmembrane signaling receptor activity
CRG85_RS19675	COG1846	Transcriptional regulator
CRG85_RS19680	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRG85_RS19685	COG1012	belongs to the aldehyde dehydrogenase family
CRG85_RS19690	COG3384	dioxygenase
CRG85_RS19700	COG3971	2-oxopent-4-enoate hydratase activity
CRG85_RS19720	COG2368	4-hydroxyphenylacetate
CRG85_RS19725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRG85_RS19730	COG1966	Carbon starvation protein
CRG85_RS19735	COG2879	small protein
CRG85_RS19740	COG0523	cobalamin synthesis protein
CRG85_RS19745	COG1715	Restriction endonuclease
CRG85_RS19750	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CRG85_RS19755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CRG85_RS19770	COG1401	restriction endodeoxyribonuclease activity
CRG85_RS19775	COG4268	DNA restriction-modification system
CRG85_RS19785	COG1196	nuclear chromosome segregation
CRG85_RS19790	COG5457	Domain of unknown function (DUF1127)
CRG85_RS19795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRG85_RS19815	COG2814	Major facilitator Superfamily
CRG85_RS19820	COG2733	membrane
CRG85_RS19825	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CRG85_RS19830	COG1924	4 iron, 4 sulfur cluster binding
CRG85_RS19845	COG0477	Major facilitator Superfamily
CRG85_RS19855	COG3366	ferrous iron transmembrane transporter activity
CRG85_RS19860	COG0700	Nucleoside recognition
CRG85_RS19865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRG85_RS19870	COG0583	DNA-binding transcription factor activity
CRG85_RS19890	COG2186	Transcriptional regulator
CRG85_RS19895	COG0246	Mannitol dehydrogenase
CRG85_RS19910	COG3539	Fimbrial protein
CRG85_RS19915	COG3539	Fimbrial protein
CRG85_RS19920	COG3539	Fimbrial protein
CRG85_RS19925	COG3188	usher protein
CRG85_RS19930	COG3121	Chaperone
CRG85_RS19935	COG3539	Fimbrial protein
CRG85_RS19945	COG4974	Belongs to the 'phage' integrase family
CRG85_RS19950	COG0582	viral genome integration into host DNA
CRG85_RS19955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRG85_RS19960	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CRG85_RS19985	COG1401	restriction endodeoxyribonuclease activity
CRG85_RS20025	COG1064	alcohol dehydrogenase
CRG85_RS20030	COG0433	COG0433 Predicted ATPase
CRG85_RS20035	COG0795	lipopolysaccharide-transporting ATPase activity
CRG85_RS20040	COG0795	lipopolysaccharide-transporting ATPase activity
CRG85_RS20050	COG2927	DNA polymerase III (CHI subunit)
CRG85_RS20055	COG0525	valine-tRNA ligase activity
CRG85_RS20060	COG4269	membrane
CRG85_RS20065	COG0456	acetyltransferase
CRG85_RS20070	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CRG85_RS20095	COG2731	YhcH YjgK YiaL family protein
CRG85_RS20100	COG1309	transcriptional regulator
CRG85_RS20105	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS20110	COG0251	oxidation-reduction process
CRG85_RS20130	COG0251	oxidation-reduction process
CRG85_RS20135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRG85_RS20145	COG1609	Transcriptional regulator
CRG85_RS20150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CRG85_RS20150	COG1263	PTS System
CRG85_RS20155	COG0366	Alpha amylase catalytic
CRG85_RS20160	COG1328	CTP reductase activity
CRG85_RS20165	COG0602	queuosine metabolic process
CRG85_RS20170	COG3783	Cytochrome b(562)
CRG85_RS20175	COG0312	modulator of DNA gyrase
CRG85_RS20185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRG85_RS20195	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS20200	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS20205	COG1129	ABC transporter
CRG85_RS20210	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS20215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRG85_RS20220	COG2105	PFAM AIG2 family protein
CRG85_RS20225	COG2911	Protein conserved in bacteria
CRG85_RS20230	COG0729	surface antigen
CRG85_RS20240	COG1253	flavin adenine dinucleotide binding
CRG85_RS20250	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CRG85_RS20255	COG1218	3'(2'),5'-bisphosphate nucleotidase
CRG85_RS20260	COG0737	Belongs to the 5'-nucleotidase family
CRG85_RS20265	COG1733	regulation of RNA biosynthetic process
CRG85_RS20270	COG0702	epimerase
CRG85_RS20275	COG0697	spore germination
CRG85_RS20285	COG1113	amino acid transport
CRG85_RS20290	COG0545	Peptidyl-prolyl cis-trans isomerase
CRG85_RS20300	COG3061	Opacity-associated protein A
CRG85_RS20305	COG1309	transcriptional regulator
CRG85_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
CRG85_RS20320	COG1024	Enoyl-CoA hydratase
CRG85_RS20325	COG4670	ketone body catabolic process
CRG85_RS20330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CRG85_RS20335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CRG85_RS20345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CRG85_RS20355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRG85_RS20390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS20395	COG3414	Phosphotransferase system galactitol-specific IIB component
CRG85_RS20400	COG3037	sugar-specific permease SgaT UlaA
CRG85_RS20415	COG1073	alpha beta
CRG85_RS20420	COG3650	response to hydrogen peroxide
CRG85_RS20430	COG1960	acyl-CoA dehydrogenase activity
CRG85_RS20440	COG5463	Belongs to the UPF0441 family
CRG85_RS20445	COG3766	membrane
CRG85_RS20455	COG1842	Phage shock protein A
CRG85_RS20460	COG3789	protein conserved in bacteria
CRG85_RS20465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRG85_RS20470	COG0557	exoribonuclease II activity
CRG85_RS20485	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CRG85_RS20490	COG0330	HflC and HflK could
CRG85_RS20495	COG0330	HflC and HflK could
CRG85_RS20500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRG85_RS20520	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRG85_RS20525	COG0802	atpase or kinase
CRG85_RS20530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRG85_RS20530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRG85_RS20535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRG85_RS20575	COG3264	Mechanosensitive ion channel
CRG85_RS20575	COG1511	domain protein
CRG85_RS20580	COG0531	amino acid
CRG85_RS20590	COG1053	succinate dehydrogenase
CRG85_RS20595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRG85_RS20610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRG85_RS20615	COG3040	lipid binding
CRG85_RS20620	COG2076	Multidrug Resistance protein
CRG85_RS20625	COG5510	response to toxic substance
CRG85_RS20630	COG5510	response to toxic substance
CRG85_RS20640	COG1509	lysine 2,3-aminomutase activity
CRG85_RS20665	COG0531	amino acid
CRG85_RS20670	COG3030	protein affecting phage T7 exclusion by the F plasmid
CRG85_RS20675	COG1027	Aspartate ammonia-lyase
CRG85_RS20680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRG85_RS20695	COG1309	transcriptional regulator
CRG85_RS20705	COG3710	Transcriptional regulator
CRG85_RS20715	COG0531	amino acid
CRG85_RS20720	COG1982	Orn Lys Arg decarboxylase major
CRG85_RS20725	COG3104	oligopeptide transport
CRG85_RS20730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRG85_RS20745	COG2388	GCN5-related N-acetyl-transferase
CRG85_RS20750	COG3592	Divergent 4Fe-4S mono-cluster
CRG85_RS20755	COG3290	protein histidine kinase activity
CRG85_RS20760	COG4565	transcriptional regulatory protein
CRG85_RS20770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRG85_RS20775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CRG85_RS20775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CRG85_RS20780	COG3647	Membrane
CRG85_RS20785	COG2211	Major facilitator Superfamily
CRG85_RS20790	COG1486	melibiose metabolic process
CRG85_RS20795	COG2169	Transcriptional regulator
CRG85_RS20800	COG1982	Orn Lys Arg decarboxylase major
CRG85_RS20805	COG2207	Transcriptional regulator
CRG85_RS20810	COG0531	amino acid
CRG85_RS20815	COG2194	sulfuric ester hydrolase activity
CRG85_RS20820	COG0745	RESPONSE REGULATOR receiver
CRG85_RS20825	COG0642	Histidine kinase
CRG85_RS20835	COG0477	Major facilitator Superfamily
CRG85_RS20845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CRG85_RS20850	COG2824	Alkylphosphonate utilization operon protein PhnA
CRG85_RS20855	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CRG85_RS20865	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CRG85_RS20870	COG3639	organic phosphonate transmembrane transporter activity
CRG85_RS20875	COG2188	Transcriptional regulator
CRG85_RS20880	COG3624	Phosphonate C-P lyase system protein PhnG
CRG85_RS20885	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CRG85_RS20890	COG3626	phosphonate metabolism
CRG85_RS20895	COG3627	carbon phosphorus lyase activity
CRG85_RS20900	COG4107	phosphonate C-P lyase system protein PhnK
CRG85_RS20905	COG4778	phosphonate C-P lyase system protein PhnL
CRG85_RS20910	COG3454	Phosphonate metabolism
CRG85_RS20915	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CRG85_RS20920	COG0456	acetyltransferase
CRG85_RS20925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CRG85_RS20935	COG0698	ribose 5-phosphate isomerase
CRG85_RS20940	COG1737	Transcriptional regulator
CRG85_RS20945	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS20950	COG1129	ABC transporter
CRG85_RS20955	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS20960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRG85_RS20965	COG1940	carbohydrate kinase activity
CRG85_RS20970	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CRG85_RS20980	COG1566	PFAM secretion protein HlyD family protein
CRG85_RS20985	COG1289	transmembrane transporter activity
CRG85_RS21000	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CRG85_RS21005	COG1301	dicarboxylic acid transport
CRG85_RS21010	COG4235	cytochrome complex assembly
CRG85_RS21015	COG3088	subunit of a heme lyase
CRG85_RS21020	COG1138	Cytochrome C-type biogenesis protein
CRG85_RS21025	COG3301	Polysulphide reductase, NrfD
CRG85_RS21030	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS21035	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CRG85_RS21045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRG85_RS21050	COG3162	membrane
CRG85_RS21065	COG0025	NhaP-type Na H and K H
CRG85_RS21070	COG2252	PERMEase
CRG85_RS21075	COG0789	Transcriptional regulator
CRG85_RS21080	COG2207	Transcriptional regulator
CRG85_RS21085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CRG85_RS21095	COG0629	single-stranded DNA binding
CRG85_RS21100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRG85_RS21105	COG2315	Protein conserved in bacteria
CRG85_RS21110	COG0432	Pfam Uncharacterised protein family UPF0047
CRG85_RS21115	COG3700	Belongs to the class B bacterial acid phosphatase family
CRG85_RS21125	COG1448	Aminotransferase
CRG85_RS21130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRG85_RS21135	COG0305	Participates in initiation and elongation during chromosome replication
CRG85_RS21140	COG0604	alcohol dehydrogenase
CRG85_RS21150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRG85_RS21165	COG0735	belongs to the Fur family
CRG85_RS21170	COG3237	CsbD-like
CRG85_RS21175	COG0534	Mate efflux family protein
CRG85_RS21185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRG85_RS21220	COG3842	ATPase activity
CRG85_RS21225	COG2182	Extracellular solute-binding protein
CRG85_RS21230	COG1175	transmembrane transport
CRG85_RS21235	COG3833	ABC-type maltose transport systems, permease component
CRG85_RS21240	COG2814	Major facilitator Superfamily
CRG85_RS21240	COG0477	Major facilitator Superfamily
CRG85_RS21255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRG85_RS21285	COG0527	aspartate kinase activity
CRG85_RS21295	COG1187	pseudouridine synthase activity
CRG85_RS21305	COG1283	sodium-dependent phosphate transmembrane transporter activity
CRG85_RS21310	COG1410	methionine synthase
CRG85_RS21310	COG0646	methionine synthase
CRG85_RS21315	COG1414	Transcriptional regulator
CRG85_RS21335	COG2224	Isocitrate lyase
CRG85_RS21340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRG85_RS21350	COG0456	acetyltransferase
CRG85_RS21380	COG0151	Belongs to the GarS family
CRG85_RS21385	COG2204	response regulator
CRG85_RS21390	COG4191	Histidine kinase
CRG85_RS21395	COG3678	ATP-independent chaperone mediated protein folding
CRG85_RS21410	COG3068	Protein conserved in bacteria
CRG85_RS21445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CRG85_RS21450	COG2104	thiamine diphosphate biosynthetic process
CRG85_RS21460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRG85_RS21500	COG0250	Participates in transcription elongation, termination and antitermination
CRG85_RS21505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRG85_RS21540	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CRG85_RS21540	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CRG85_RS21575	COG4206	TonB-dependent receptor
CRG85_RS21590	COG1309	transcriptional regulator
CRG85_RS21600	COG0583	DNA-binding transcription factor activity
CRG85_RS21615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CRG85_RS21630	COG2194	sulfuric ester hydrolase activity
CRG85_RS21635	COG2207	Transcriptional regulator
CRG85_RS21640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS21645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CRG85_RS21650	COG1882	Formate acetyltransferase
CRG85_RS21655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS21660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS21665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS21665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRG85_RS21665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS21670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRG85_RS21675	COG0371	Dehydrogenase
CRG85_RS21680	COG3738	Protein conserved in bacteria
CRG85_RS21685	COG0697	spore germination
CRG85_RS21695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CRG85_RS21700	COG0527	aspartate kinase activity
CRG85_RS21700	COG0460	homoserine dehydrogenase
CRG85_RS21705	COG0626	cystathionine gamma-synthase activity
CRG85_RS21715	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CRG85_RS21725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRG85_RS21730	COG1609	Transcriptional regulator
CRG85_RS21735	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRG85_RS21750	COG1575	Belongs to the MenA family. Type 1 subfamily
CRG85_RS21765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRG85_RS21775	COG1494	fructose-1,6-bisphosphatase
CRG85_RS21780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG85_RS21785	COG0589	response to stress
CRG85_RS21790	COG3691	Protein conserved in bacteria
CRG85_RS21795	COG3152	Membrane
CRG85_RS21815	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CRG85_RS21890	COG5301	cellulose 1,4-beta-cellobiosidase activity
CRG85_RS21980	COG4695	Portal protein
CRG85_RS22050	COG4974	Belongs to the 'phage' integrase family
CRG85_RS22055	COG3678	ATP-independent chaperone mediated protein folding
CRG85_RS22060	COG0745	RESPONSE REGULATOR receiver
CRG85_RS22065	COG2205	protein histidine kinase activity
CRG85_RS22070	COG2258	MOSC domain
CRG85_RS22080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRG85_RS22125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS22130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS22130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CRG85_RS22135	COG1363	Peptidase, m42
CRG85_RS22140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRG85_RS22140	COG3711	transcriptional antiterminator
CRG85_RS22155	COG3383	formate dehydrogenase (NAD+) activity
CRG85_RS22155	COG0243	molybdopterin cofactor binding
CRG85_RS22160	COG3383	formate dehydrogenase (NAD+) activity
CRG85_RS22160	COG0243	molybdopterin cofactor binding
CRG85_RS22165	COG0437	4 iron, 4 sulfur cluster binding
CRG85_RS22170	COG2864	formate dehydrogenase
CRG85_RS22180	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRG85_RS22185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CRG85_RS22190	COG0456	acetyltransferase
CRG85_RS22205	COG1011	Hydrolase
CRG85_RS22210	COG1349	DNA-binding transcription factor activity
CRG85_RS22215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS22220	COG2084	Dehydrogenase
CRG85_RS22225	COG3684	Belongs to the aldolase LacD family
CRG85_RS22230	COG2942	2-epimerase
CRG85_RS22235	COG2017	converts alpha-aldose to the beta-anomer
CRG85_RS22245	COG1501	Belongs to the glycosyl hydrolase 31 family
CRG85_RS22250	COG2211	Major facilitator Superfamily
CRG85_RS22255	COG2211	Major facilitator Superfamily
CRG85_RS22260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CRG85_RS22270	COG1082	Xylose isomerase domain protein TIM barrel
CRG85_RS22275	COG2188	Transcriptional regulator
CRG85_RS22280	COG1217	gtp-binding protein TYPA
CRG85_RS22285	COG0174	glutamine synthetase
CRG85_RS22290	COG3852	Histidine kinase
CRG85_RS22295	COG2204	response regulator
CRG85_RS22305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRG85_RS22310	COG3078	GTPase activator activity
CRG85_RS22320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRG85_RS22320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRG85_RS22330	COG0204	Acyl-transferase
CRG85_RS22335	COG5339	Protein conserved in bacteria
CRG85_RS22340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRG85_RS22345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CRG85_RS22350	COG3084	Protein conserved in bacteria
CRG85_RS22355	COG0746	molybdenum cofactor guanylyltransferase activity
CRG85_RS22360	COG1763	Mo-molybdopterin cofactor biosynthetic process
CRG85_RS22390	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CRG85_RS22395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRG85_RS22400	COG1739	Uncharacterized protein family UPF0029
CRG85_RS22420	COG0543	2 iron, 2 sulfur cluster binding
CRG85_RS22425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRG85_RS22430	COG0250	Participates in transcription elongation, termination and antitermination
CRG85_RS22440	COG0805	protein transport
CRG85_RS22445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRG85_RS22450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRG85_RS22460	COG3165	ubiquinone biosynthetic process from chorismate
CRG85_RS22470	COG1322	Protein conserved in bacteria
CRG85_RS22475	COG1414	Transcriptional regulator
CRG85_RS22480	COG3734	2-keto-3-deoxy-galactonokinase
CRG85_RS22505	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CRG85_RS22510	COG0412	Dienelactone hydrolase
CRG85_RS22515	COG1335	isochorismatase
CRG85_RS22525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRG85_RS22530	COG1304	FMN binding
CRG85_RS22535	COG0549	Belongs to the carbamate kinase family
CRG85_RS22545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CRG85_RS22550	COG0583	DNA-binding transcription factor activity
CRG85_RS22560	COG0583	DNA-binding transcription factor activity
CRG85_RS22565	COG0697	spore germination
CRG85_RS22570	COG0561	phosphatase activity
CRG85_RS22575	COG2267	carboxylic ester hydrolase activity
CRG85_RS22580	COG1280	lysine exporter protein (LysE YggA)
CRG85_RS22585	COG1280	lysine exporter protein (LysE YggA)
CRG85_RS22590	COG0514	ATP-dependent DNA helicase (RecQ)
CRG85_RS22595	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CRG85_RS22600	COG2050	protein possibly involved in aromatic compounds catabolism
CRG85_RS22605	COG2962	Rard protein
CRG85_RS22620	COG0598	Magnesium transport protein CorA
CRG85_RS22625	COG3698	Phosphodiester glycosidase
CRG85_RS22630	COG0210	DNA helicase
CRG85_RS22635	COG1011	Hydrolase
CRG85_RS22645	COG3159	Protein conserved in bacteria
CRG85_RS22655	COG5567	small periplasmic lipoprotein
CRG85_RS22670	COG3072	Adenylate cyclase
CRG85_RS22680	COG1587	Uroporphyrinogen-III synthase
CRG85_RS22685	COG2959	enzyme of heme biosynthesis
CRG85_RS22690	COG3071	HemY protein
CRG85_RS22695	COG3119	arylsulfatase activity
CRG85_RS22700	COG0641	radical SAM
CRG85_RS22725	COG1113	amino acid transport
CRG85_RS22745	COG2244	polysaccharide biosynthetic process
CRG85_RS22750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRG85_RS22755	COG0456	acetyltransferase
CRG85_RS22760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CRG85_RS22765	COG1088	dTDP-glucose 4,6-dehydratase activity
CRG85_RS22770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CRG85_RS22775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRG85_RS22780	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CRG85_RS22785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRG85_RS22790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CRG85_RS22800	COG3118	belongs to the thioredoxin family
CRG85_RS22815	COG0210	DNA helicase
CRG85_RS22820	COG3692	DNA binding
CRG85_RS22825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRG85_RS22835	COG0583	DNA-binding transcription factor activity
CRG85_RS22840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRG85_RS22850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRG85_RS22855	COG3978	acetolactate synthase activity
CRG85_RS22875	COG0606	chelatase, subunit chli
CRG85_RS22880	COG3085	chromosome segregation
CRG85_RS22920	COG2186	Transcriptional regulator
CRG85_RS22925	COG0477	Major facilitator Superfamily
CRG85_RS22930	COG1609	Transcriptional regulator
CRG85_RS22935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG85_RS22940	COG1879	ABC-type sugar transport system periplasmic component
CRG85_RS22945	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRG85_RS22950	COG1129	ABC transporter
CRG85_RS22980	COG1522	sequence-specific DNA binding
CRG85_RS22985	COG0716	FMN binding
CRG85_RS23000	COG3312	ion transport
CRG85_RS23050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRG85_RS23055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRG85_RS23060	COG0573	inorganic phosphate transmembrane transporter activity
CRG85_RS23065	COG0581	inorganic phosphate transmembrane transporter activity
CRG85_RS23070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRG85_RS23075	COG0704	Plays a role in the regulation of phosphate uptake
CRG85_RS23080	COG3711	transcriptional antiterminator
CRG85_RS23090	COG2723	6-phospho-beta-galactosidase activity
CRG85_RS23100	COG2382	esterase
CRG85_RS23105	COG0363	glucosamine-6-phosphate deaminase activity
CRG85_RS23110	COG3196	Protein conserved in bacteria
CRG85_RS23120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRG85_RS23125	COG2252	PERMEase
CRG85_RS23130	COG0431	NADPH-dependent FMN reductase
CRG85_RS23135	COG2091	lysine biosynthetic process via aminoadipic acid
CRG85_RS23150	COG0814	amino acid
CRG85_RS23340	COG3385	transposase activity
CRG85_RS23505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRG85_RS23525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRG85_RS23525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CRG85_RS23565	COG4221	oxidoreductase activity
CRG85_RS23650	COG1695	Transcriptional regulator
CRG85_RS23880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRG85_RS23960	COG3173	Aminoglycoside phosphotransferase
CRG85_RS24065	COG3550	peptidyl-serine autophosphorylation
CRG85_RS24155	COG1358	cellular component organization or biogenesis
CRG85_RS24185	COG4245	von Willebrand factor, type A
CRG85_RS24190	COG4245	von Willebrand factor, type A
CRG85_RS24235	COG2826	transposase and inactivated derivatives, IS30 family
CRG85_RS24345	COG0210	DNA helicase
CRG85_RS24430	COG1192	Involved in chromosome partitioning
CRG85_RS24595	COG2890	protein-(glutamine-N5) methyltransferase activity
CRG85_RS24680	COG2200	EAL domain
CRG85_RS24755	COG3173	Aminoglycoside phosphotransferase
CRG85_RS24795	COG0675	Transposase, IS605 OrfB family
CRG85_RS24935	COG3344	reverse transcriptase
CRG85_RS25100	COG5001	Diguanylate cyclase
CRG85_RS25100	COG3300	MHYT domain
CRG85_RS25260	COG3385	transposase activity
CRG85_RS25315	COG2826	transposase and inactivated derivatives, IS30 family
CRG85_RS25575	COG2207	Transcriptional regulator
CRG85_RS25635	COG5301	cellulose 1,4-beta-cellobiosidase activity
CRG85_RS25665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CRG85_RS25855	COG0756	dUTP diphosphatase activity
CRG85_RS25875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRG85_RS25945	COG1403	HNH endonuclease
CRG85_RS25970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP