locus-tag	class	description
D3W53_RS00010	COG0592	DNA-directed DNA polymerase activity
D3W53_RS00020	COG0187	DNA topoisomerase II activity
D3W53_RS00025	COG3753	Protein conserved in bacteria
D3W53_RS00030	COG0561	phosphatase activity
D3W53_RS00040	COG2186	Transcriptional regulator
D3W53_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
D3W53_RS00050	COG0800	Aldolase
D3W53_RS00060	COG2271	Major facilitator Superfamily
D3W53_RS00065	COG0644	oxidoreductase
D3W53_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
D3W53_RS00075	COG5645	(Lipo)protein
D3W53_RS00095	COG2188	Transcriptional regulator
D3W53_RS00120	COG0675	Transposase, IS605 OrfB family
D3W53_RS00125	COG2149	membrane
D3W53_RS00135	COG0641	radical SAM
D3W53_RS00140	COG2814	Major facilitator Superfamily
D3W53_RS00165	COG0028	Belongs to the TPP enzyme family
D3W53_RS00170	COG0440	acetolactate synthase activity
D3W53_RS00175	COG2197	response regulator
D3W53_RS00180	COG3851	Histidine kinase
D3W53_RS00185	COG2271	Major facilitator Superfamily
D3W53_RS00190	COG2271	Major facilitator Superfamily
D3W53_RS00200	COG2252	PERMEase
D3W53_RS00225	COG1464	Belongs to the NlpA lipoprotein family
D3W53_RS00230	COG0697	spore germination
D3W53_RS00235	COG2814	Major facilitator Superfamily
D3W53_RS00250	COG2211	Major facilitator Superfamily
D3W53_RS00255	COG1501	Belongs to the glycosyl hydrolase 31 family
D3W53_RS00260	COG2982	Protein involved in outer membrane biogenesis
D3W53_RS00265	COG2233	PERMEase
D3W53_RS00270	COG0786	glutamate:sodium symporter activity
D3W53_RS00275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3W53_RS00280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3W53_RS00285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3W53_RS00295	COG0194	GDP metabolic process
D3W53_RS00305	COG2860	membrane
D3W53_RS00310	COG3645	SOS response
D3W53_RS00315	COG1561	YicC-like family, N-terminal region
D3W53_RS00345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3W53_RS00375	COG1519	Transferase
D3W53_RS00385	COG0438	transferase activity, transferring glycosyl groups
D3W53_RS00390	COG0515	serine threonine protein kinase
D3W53_RS00405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3W53_RS00410	COG1442	glycosyl transferase family 8
D3W53_RS00415	COG1216	Glycosyl transferase, family 2
D3W53_RS00420	COG3307	-O-antigen
D3W53_RS00425	COG0859	PFAM glycosyl transferase family 9
D3W53_RS00430	COG0859	PFAM glycosyl transferase family 9
D3W53_RS00445	COG0156	8-amino-7-oxononanoate synthase activity
D3W53_RS00455	COG1216	Glycosyl transferase, family 2
D3W53_RS00460	COG2861	carbohydrate metabolic process
D3W53_RS00465	COG4942	peptidase
D3W53_RS00470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3W53_RS00480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3W53_RS00485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3W53_RS00500	COG1045	serine acetyltransferase
D3W53_RS00505	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3W53_RS00515	COG2186	Transcriptional regulator
D3W53_RS00520	COG1620	l-lactate permease
D3W53_RS00540	COG3722	fumarate hydratase activity
D3W53_RS00550	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS00550	COG2213	PTS system mannitol-specific
D3W53_RS00560	COG1566	PFAM secretion protein HlyD family protein
D3W53_RS00580	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D3W53_RS00585	COG3209	COG3209 Rhs family protein
D3W53_RS00590	COG1413	lyase activity
D3W53_RS00595	COG3209	COG3209 Rhs family protein
D3W53_RS00600	COG0625	glutathione transferase activity
D3W53_RS00610	COG3276	selenocysteine insertion sequence binding
D3W53_RS00615	COG1454	alcohol dehydrogenase
D3W53_RS00620	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS00635	COG1566	PFAM secretion protein HlyD family protein
D3W53_RS00640	COG0583	DNA-binding transcription factor activity
D3W53_RS00645	COG3713	MltA-interacting MipA family protein
D3W53_RS00655	COG0235	Class ii aldolase
D3W53_RS00660	COG3623	hexulose-6-phosphate isomerase
D3W53_RS00665	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D3W53_RS00670	COG1070	Carbohydrate kinase
D3W53_RS00675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3W53_RS00680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3W53_RS00685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3W53_RS00690	COG2731	YhcH YjgK YiaL family protein
D3W53_RS00700	COG1414	Transcriptional regulator
D3W53_RS00705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS00710	COG3977	Valine--pyruvate aminotransferase
D3W53_RS00715	COG0366	Alpha amylase catalytic
D3W53_RS00720	COG2992	FlgJ-related protein
D3W53_RS00725	COG2207	Transcriptional regulator
D3W53_RS00725	COG1609	Transcriptional regulator
D3W53_RS00730	COG4214	carbohydrate transport
D3W53_RS00735	COG1129	ABC transporter
D3W53_RS00740	COG4213	ABC transporter substrate-binding protein
D3W53_RS00750	COG1070	Carbohydrate kinase
D3W53_RS00755	COG4682	membrane
D3W53_RS00760	COG4682	membrane
D3W53_RS00765	COG3274	enterobacterial common antigen metabolic process
D3W53_RS00795	COG1278	Cold shock
D3W53_RS00800	COG2944	sequence-specific DNA binding
D3W53_RS00815	COG2885	chlorophyll binding
D3W53_RS00820	COG0243	molybdopterin cofactor binding
D3W53_RS00825	COG0456	acetyltransferase
D3W53_RS00830	COG2818	Glycosylase
D3W53_RS00835	COG5571	outer membrane autotransporter
D3W53_RS00845	COG2223	nitrite transmembrane transporter activity
D3W53_RS00850	COG2194	sulfuric ester hydrolase activity
D3W53_RS00870	COG0747	negative chemotaxis
D3W53_RS00875	COG0601	transmembrane transport
D3W53_RS00880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3W53_RS00885	COG0444	Belongs to the ABC transporter superfamily
D3W53_RS00890	COG4608	Belongs to the ABC transporter superfamily
D3W53_RS00895	COG0814	amino acid
D3W53_RS00915	COG2194	sulfuric ester hydrolase activity
D3W53_RS00940	COG1215	transferase activity, transferring glycosyl groups
D3W53_RS00945	COG1215	transferase activity, transferring glycosyl groups
D3W53_RS00950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D3W53_RS00955	COG3118	belongs to the thioredoxin family
D3W53_RS00955	COG0457	Tetratricopeptide repeat
D3W53_RS00960	COG2199	diguanylate cyclase activity
D3W53_RS00960	COG2200	EAL domain
D3W53_RS00970	COG0612	Peptidase, M16
D3W53_RS00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS00985	COG2200	EAL domain
D3W53_RS00990	COG2982	Protein involved in outer membrane biogenesis
D3W53_RS00995	COG0477	Major facilitator Superfamily
D3W53_RS01000	COG1295	ribonuclease BN
D3W53_RS01005	COG0583	DNA-binding transcription factor activity
D3W53_RS01020	COG2197	response regulator
D3W53_RS01030	COG1858	cytochrome C peroxidase
D3W53_RS01035	COG0076	glutamate decarboxylase activity
D3W53_RS01040	COG2207	Transcriptional regulator
D3W53_RS01045	COG2207	Transcriptional regulator
D3W53_RS01055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3W53_RS01060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS01070	COG2771	luxR family
D3W53_RS01075	COG3247	response to pH
D3W53_RS01090	COG1285	pathogenesis
D3W53_RS01095	COG2197	response regulator
D3W53_RS01105	COG3065	identical protein binding
D3W53_RS01115	COG1393	Belongs to the ArsC family
D3W53_RS01120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3W53_RS01125	COG0640	Transcriptional regulator
D3W53_RS01140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3W53_RS01145	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3W53_RS01150	COG0339	signal peptide processing
D3W53_RS01160	COG3104	oligopeptide transport
D3W53_RS01165	COG0589	response to stress
D3W53_RS01175	COG0306	phosphate transporter
D3W53_RS01180	COG2081	HI0933 family
D3W53_RS01200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS01205	COG0842	Transport permease protein
D3W53_RS01205	COG1129	ABC transporter
D3W53_RS01210	COG0842	Transport permease protein
D3W53_RS01215	COG5433	transposase activity
D3W53_RS01220	COG1413	lyase activity
D3W53_RS01230	COG3209	COG3209 Rhs family protein
D3W53_RS01240	COG1124	(ABC) transporter
D3W53_RS01245	COG0444	Belongs to the ABC transporter superfamily
D3W53_RS01250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3W53_RS01255	COG0601	transmembrane transport
D3W53_RS01260	COG0747	negative chemotaxis
D3W53_RS01265	COG2091	lysine biosynthetic process via aminoadipic acid
D3W53_RS01270	COG0628	permease
D3W53_RS01275	COG0477	Major facilitator Superfamily
D3W53_RS01285	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D3W53_RS01295	COG2217	Heavy metal translocating P-type atpase
D3W53_RS01300	COG3714	YhhN family
D3W53_RS01310	COG3776	membrane
D3W53_RS01315	COG0742	ribosomal rna small subunit methyltransferase
D3W53_RS01320	COG0552	protein localization to endoplasmic reticulum
D3W53_RS01325	COG2884	Cell division ATP-binding protein ftsE
D3W53_RS01330	COG2177	Part of the ABC transporter FtsEX involved in
D3W53_RS01335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3W53_RS01340	COG0683	leucine binding
D3W53_RS01345	COG0456	acetyltransferase
D3W53_RS01350	COG0683	leucine binding
D3W53_RS01355	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS01360	COG4177	L-phenylalanine transmembrane transporter activity
D3W53_RS01365	COG0411	ABC transporter
D3W53_RS01370	COG0410	ABC transporter
D3W53_RS01375	COG1653	transport
D3W53_RS01380	COG1175	transmembrane transport
D3W53_RS01385	COG0395	ABC-type sugar transport system, permease component
D3W53_RS01390	COG3842	ATPase activity
D3W53_RS01395	COG0584	glycerophosphoryl diester phosphodiesterase
D3W53_RS01405	COG0405	Gamma-glutamyltransferase
D3W53_RS01425	COG3157	Type VI secretion system effector, Hcp
D3W53_RS01430	COG1247	-acetyltransferase
D3W53_RS01440	COG0673	inositol 2-dehydrogenase activity
D3W53_RS01445	COG1741	Belongs to the pirin family
D3W53_RS01450	COG1609	Transcriptional regulator
D3W53_RS01455	COG3265	gluconokinase activity
D3W53_RS01460	COG2610	gluconate transmembrane transporter activity
D3W53_RS01465	COG2095	MarC family integral membrane protein
D3W53_RS01470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3W53_RS01495	COG0058	SHG alpha-glucan phosphorylase activity
D3W53_RS01500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3W53_RS01505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3W53_RS01520	COG1349	DNA-binding transcription factor activity
D3W53_RS01525	COG4650	regulator
D3W53_RS01530	COG1690	Belongs to the RtcB family
D3W53_RS01545	COG0058	SHG alpha-glucan phosphorylase activity
D3W53_RS01550	COG1640	4-alpha-glucanotransferase
D3W53_RS01555	COG2610	gluconate transmembrane transporter activity
D3W53_RS01575	COG5464	transposase or invertase
D3W53_RS01590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D3W53_RS01595	COG1918	ferrous iron import across plasma membrane
D3W53_RS01605	COG2183	response to ionizing radiation
D3W53_RS01610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3W53_RS01640	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D3W53_RS01650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3W53_RS01655	COG1011	Hydrolase
D3W53_RS01665	COG0494	nUDIX hydrolase
D3W53_RS01670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3W53_RS01675	COG4972	Pilus assembly protein
D3W53_RS01680	COG3166	PFAM Fimbrial assembly family protein
D3W53_RS01695	COG4796	Type ii and iii secretion system protein
D3W53_RS01710	COG3266	domain, Protein
D3W53_RS01715	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D3W53_RS01720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3W53_RS01730	COG0180	Tryptophanyl-tRNA synthetase
D3W53_RS01740	COG2188	Transcriptional regulator
D3W53_RS01750	COG3457	Alanine racemase
D3W53_RS01755	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D3W53_RS01760	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D3W53_RS01775	COG0626	cystathionine gamma-synthase activity
D3W53_RS01780	COG2188	Transcriptional regulator
D3W53_RS01785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS01790	COG1082	Xylose isomerase domain protein TIM barrel
D3W53_RS01800	COG2222	sugar isomerase
D3W53_RS01805	COG0531	amino acid
D3W53_RS01820	COG2116	formate transmembrane transporter activity
D3W53_RS01825	COG2146	nitrite reductase [NAD(P)H] activity
D3W53_RS01830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3W53_RS01840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3W53_RS01850	COG2184	nucleotidyltransferase activity
D3W53_RS01855	COG0512	Glutamine amidotransferase of anthranilate synthase
D3W53_RS01860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3W53_RS01865	COG1289	transmembrane transporter activity
D3W53_RS01870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3W53_RS01880	COG1765	OsmC-like protein
D3W53_RS01885	COG3954	Phosphoribulokinase
D3W53_RS01895	COG0429	hydrolase of the alpha beta-hydrolase fold
D3W53_RS01900	COG0488	(ABC) transporter
D3W53_RS01920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D3W53_RS01925	COG1047	Peptidyl-prolyl cis-trans
D3W53_RS01935	COG0545	Peptidyl-prolyl cis-trans isomerase
D3W53_RS01940	COG2964	Protein conserved in bacteria
D3W53_RS01985	COG3979	chitinase
D3W53_RS01990	COG2906	2 iron, 2 sulfur cluster binding
D3W53_RS01995	COG2193	ferroxidase activity
D3W53_RS02000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D3W53_RS02005	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3W53_RS02010	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3W53_RS02015	COG3156	type II secretion system protein K
D3W53_RS02020	COG4795	General secretion pathway protein
D3W53_RS02025	COG2165	general secretion pathway protein
D3W53_RS02030	COG2165	general secretion pathway protein
D3W53_RS02035	COG2165	general secretion pathway protein
D3W53_RS02040	COG1459	type II secretion system
D3W53_RS02045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3W53_RS02050	COG1450	Type ii and iii secretion system protein
D3W53_RS02055	COG3031	protein transport across the cell outer membrane
D3W53_RS02060	COG3267	Type II secretory pathway component ExeA
D3W53_RS02060	COG3409	Peptidoglycan-binding domain 1 protein
D3W53_RS02085	COG0089	rRNA binding
D3W53_RS02175	COG0201	protein transport
D3W53_RS02215	COG0789	Transcriptional regulator
D3W53_RS02220	COG3036	rescue of stalled ribosome
D3W53_RS02230	COG0569	domain protein
D3W53_RS02250	COG0758	DNA mediated transformation
D3W53_RS02260	COG0551	DNA topoisomerase type I activity
D3W53_RS02280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3W53_RS02320	COG1126	abc transporter atp-binding protein
D3W53_RS02325	COG0765	amino acid transport
D3W53_RS02330	COG4597	amino acid ABC transporter
D3W53_RS02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS02350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3W53_RS02355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS02365	COG1309	transcriptional regulator
D3W53_RS02375	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3W53_RS02385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3W53_RS02395	COG4145	pantothenate transmembrane transporter activity
D3W53_RS02400	COG3924	membrane
D3W53_RS02405	COG0439	Biotin carboxylase
D3W53_RS02410	COG0511	ligase activity, forming carbon-carbon bonds
D3W53_RS02415	COG0604	alcohol dehydrogenase
D3W53_RS02420	COG2200	EAL domain
D3W53_RS02420	COG2199	diguanylate cyclase activity
D3W53_RS02430	COG1077	Cell shape determining protein MreB Mrl
D3W53_RS02435	COG1792	Involved in formation and maintenance of cell shape
D3W53_RS02440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D3W53_RS02445	COG0424	maF-like protein
D3W53_RS02450	COG1530	ribonuclease E activity
D3W53_RS02455	COG3164	Protein of unknown function
D3W53_RS02460	COG0312	modulator of DNA gyrase
D3W53_RS02465	COG0583	DNA-binding transcription factor activity
D3W53_RS02485	COG2732	(Barnase) inhibitor
D3W53_RS02505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3W53_RS02510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3W53_RS02515	COG3105	Protein conserved in bacteria
D3W53_RS02520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3W53_RS02535	COG0625	glutathione transferase activity
D3W53_RS02540	COG2969	positive regulation of protein catabolic process
D3W53_RS02545	COG3069	C4-dicarboxylate transmembrane transporter activity
D3W53_RS02580	COG2731	YhcH YjgK YiaL family protein
D3W53_RS02585	COG4804	nuclease activity
D3W53_RS02600	COG0493	'glutamate synthase
D3W53_RS02605	COG0069	glutamate synthase activity
D3W53_RS02605	COG0067	glutamate synthase
D3W53_RS02605	COG0070	glutamate synthase
D3W53_RS02620	COG1242	4 iron, 4 sulfur cluster binding
D3W53_RS02625	COG2198	Histidine kinase
D3W53_RS02625	COG5002	protein histidine kinase activity
D3W53_RS02625	COG0784	Response regulator, receiver
D3W53_RS02630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D3W53_RS02640	COG0515	serine threonine protein kinase
D3W53_RS02645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS02660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3W53_RS02665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3W53_RS02670	COG1137	ATPase activity
D3W53_RS02675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D3W53_RS02680	COG3117	lipopolysaccharide transmembrane transporter activity
D3W53_RS02685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D3W53_RS02690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D3W53_RS02690	COG0517	IMP dehydrogenase activity
D3W53_RS02695	COG0530	calcium, potassium:sodium antiporter activity
D3W53_RS02700	COG1127	ABC transporter
D3W53_RS02705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3W53_RS02710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3W53_RS02715	COG2854	intermembrane phospholipid transfer
D3W53_RS02720	COG3113	response to antibiotic
D3W53_RS02725	COG5007	Belongs to the BolA IbaG family
D3W53_RS02735	COG3423	Transcriptional regulator
D3W53_RS02740	COG0142	geranyltranstransferase activity
D3W53_RS02755	COG0697	spore germination
D3W53_RS02765	COG2027	D-alanyl-D-alanine carboxypeptidase
D3W53_RS02770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3W53_RS02775	COG1534	Rna-binding protein
D3W53_RS02785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3W53_RS02790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3W53_RS02800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3W53_RS02835	COG0195	Participates in both transcription termination and antitermination
D3W53_RS02875	COG0513	Belongs to the DEAD box helicase family
D3W53_RS02880	COG0814	amino acid
D3W53_RS02885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3W53_RS02890	COG0826	peptidase U32
D3W53_RS02895	COG0826	peptidase U32
D3W53_RS02900	COG3154	lipid carrier protein
D3W53_RS02905	COG3153	acetyltransferase
D3W53_RS02920	COG0693	protein deglycase activity
D3W53_RS02925	COG0702	epimerase
D3W53_RS02930	COG0701	Predicted permease
D3W53_RS02935	COG2823	Periplasmic or secreted lipoprotein
D3W53_RS02950	COG3107	peptidoglycan biosynthetic process
D3W53_RS02955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3W53_RS02960	COG3539	Fimbrial protein
D3W53_RS02965	COG3188	usher protein
D3W53_RS02970	COG3121	Chaperone
D3W53_RS02975	COG3539	Fimbrial protein
D3W53_RS02980	COG0363	glucosamine-6-phosphate deaminase activity
D3W53_RS02985	COG3716	PTS system mannose fructose sorbose family IID component
D3W53_RS02990	COG3715	PTS system
D3W53_RS02995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS03005	COG2222	sugar isomerase
D3W53_RS03010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3W53_RS03015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS03020	COG3716	PTS system mannose fructose sorbose family IID component
D3W53_RS03030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS03040	COG1349	DNA-binding transcription factor activity
D3W53_RS03050	COG2002	toxin-antitoxin pair type II binding
D3W53_RS03055	COG2721	sulfolactate sulfo-lyase activity
D3W53_RS03060	COG2271	Major facilitator Superfamily
D3W53_RS03070	COG2084	Dehydrogenase
D3W53_RS03075	COG1929	Belongs to the glycerate kinase type-1 family
D3W53_RS03105	COG0583	DNA-binding transcription factor activity
D3W53_RS03115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3W53_RS03125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3W53_RS03130	COG1882	Formate acetyltransferase
D3W53_RS03135	COG0251	oxidation-reduction process
D3W53_RS03140	COG1760	l-serine dehydratase
D3W53_RS03150	COG0814	amino acid
D3W53_RS03165	COG1741	Belongs to the pirin family
D3W53_RS03170	COG0583	DNA-binding transcription factor activity
D3W53_RS03180	COG3152	Membrane
D3W53_RS03200	COG3152	Membrane
D3W53_RS03205	COG0435	Glutathione S-transferase
D3W53_RS03210	COG2259	Doxx family
D3W53_RS03220	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
D3W53_RS03225	COG4575	ribosome binding
D3W53_RS03230	COG1422	Protein of unknown function (DUF1090)
D3W53_RS03240	COG0586	Pfam SNARE associated Golgi protein
D3W53_RS03245	COG2186	Transcriptional regulator
D3W53_RS03250	COG2271	Major facilitator Superfamily
D3W53_RS03260	COG2721	sulfolactate sulfo-lyase activity
D3W53_RS03270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D3W53_RS03280	COG0861	Integral membrane protein TerC family
D3W53_RS03285	COG0673	inositol 2-dehydrogenase activity
D3W53_RS03290	COG2949	membrane
D3W53_RS03295	COG1451	nucleotide metabolic process
D3W53_RS03305	COG4680	protein conserved in bacteria
D3W53_RS03310	COG5499	transcription regulator containing HTH domain
D3W53_RS03315	COG1902	pentaerythritol trinitrate reductase activity
D3W53_RS03315	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3W53_RS03320	COG3408	Glycogen debranching enzyme
D3W53_RS03320	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D3W53_RS03330	COG0531	amino acid
D3W53_RS03335	COG2731	YhcH YjgK YiaL family protein
D3W53_RS03340	COG3250	beta-galactosidase activity
D3W53_RS03345	COG1609	Transcriptional regulator
D3W53_RS03350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3W53_RS03365	COG0840	transmembrane signaling receptor activity
D3W53_RS03370	COG1695	Transcriptional regulator
D3W53_RS03375	COG2375	cellular response to nickel ion
D3W53_RS03390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3W53_RS03395	COG0358	DNA primase activity
D3W53_RS03400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3W53_RS03410	COG0471	metal ion transport
D3W53_RS03415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3W53_RS03420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3W53_RS03430	COG0583	DNA-binding transcription factor activity
D3W53_RS03440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3W53_RS03455	COG4991	sh3 domain protein
D3W53_RS03465	COG3025	triphosphatase activity
D3W53_RS03485	COG2268	Band 7 protein
D3W53_RS03490	COG1585	Membrane protein implicated in regulation of membrane protease activity
D3W53_RS03530	COG3384	dioxygenase
D3W53_RS03535	COG0754	glutathionylspermidine amidase activity
D3W53_RS03550	COG1538	Outer membrane efflux protein
D3W53_RS03555	COG0494	nUDIX hydrolase
D3W53_RS03560	COG3151	Protein conserved in bacteria
D3W53_RS03565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3W53_RS03570	COG3150	esterase
D3W53_RS03575	COG0187	DNA topoisomerase II activity
D3W53_RS03580	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D3W53_RS03585	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3W53_RS03590	COG0642	Histidine kinase
D3W53_RS03595	COG0745	RESPONSE REGULATOR receiver
D3W53_RS03600	COG3111	PFAM Bacterial OB fold (BOF) protein
D3W53_RS03605	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D3W53_RS03610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3W53_RS03615	COG0204	Acyl-transferase
D3W53_RS03620	COG2132	Multicopper oxidase
D3W53_RS03625	COG1032	radical SAM domain protein
D3W53_RS03640	COG4238	major outer membrane lipoprotein
D3W53_RS03650	COG0656	L-ascorbic acid biosynthetic process
D3W53_RS03655	COG1979	alcohol dehydrogenase
D3W53_RS03660	COG2207	Transcriptional regulator
D3W53_RS03665	COG0586	Pfam SNARE associated Golgi protein
D3W53_RS03670	COG0626	cystathionine gamma-synthase activity
D3W53_RS03680	COG0811	peptide transport
D3W53_RS03685	COG0848	biopolymer transport protein
D3W53_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS03700	COG0667	Aldo Keto reductase
D3W53_RS03720	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3W53_RS03725	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS03730	COG5557	Pfam Polysulphide reductase, NrfD
D3W53_RS03735	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3W53_RS03740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3W53_RS03745	COG1773	rubredoxin
D3W53_RS03755	COG0298	carbon dioxide binding
D3W53_RS03760	COG0625	glutathione transferase activity
D3W53_RS03765	COG0754	glutathionylspermidine amidase activity
D3W53_RS03775	COG0456	acetyltransferase
D3W53_RS03780	COG2186	Transcriptional regulator
D3W53_RS03785	COG0277	FAD linked oxidase domain protein
D3W53_RS03790	COG0277	FAD linked oxidase domain protein
D3W53_RS03795	COG0247	lactate metabolic process
D3W53_RS03800	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D3W53_RS03805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3W53_RS03810	COG1620	l-lactate permease
D3W53_RS03815	COG3064	Membrane
D3W53_RS03845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3W53_RS03850	COG1459	type II secretion system
D3W53_RS03855	COG2165	general secretion pathway protein
D3W53_RS03885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D3W53_RS03910	COG1216	Glycosyl transferase, family 2
D3W53_RS03915	COG0562	UDP-galactopyranose mutase
D3W53_RS03920	COG0110	maltose O-acetyltransferase activity
D3W53_RS03930	COG1215	transferase activity, transferring glycosyl groups
D3W53_RS04000	COG2003	Belongs to the UPF0758 family
D3W53_RS04035	COG1811	Na channel or pump
D3W53_RS04045	COG1982	Orn Lys Arg decarboxylase major
D3W53_RS04050	COG2211	Major facilitator Superfamily
D3W53_RS04065	COG1194	a g-specific adenine glycosylase
D3W53_RS04075	COG3171	Protein conserved in bacteria
D3W53_RS04085	COG0252	asparaginase activity
D3W53_RS04095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3W53_RS04100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3W53_RS04110	COG0762	integral membrane protein
D3W53_RS04115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3W53_RS04120	COG2805	Type II/IV secretion system protein
D3W53_RS04135	COG0189	ligase activity
D3W53_RS04140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3W53_RS04145	COG2356	endonuclease I
D3W53_RS04155	COG2814	Major facilitator Superfamily
D3W53_RS04180	COG1166	arginine decarboxylase activity
D3W53_RS04195	COG0501	Belongs to the peptidase M48B family
D3W53_RS04200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3W53_RS04205	COG0330	HflC and HflK could
D3W53_RS04215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS04220	COG2213	PTS system mannitol-specific
D3W53_RS04225	COG1063	alcohol dehydrogenase
D3W53_RS04230	COG1494	fructose-1,6-bisphosphatase
D3W53_RS04235	COG3722	fumarate hydratase activity
D3W53_RS04240	COG1072	(Pantothenic acid kinase))
D3W53_RS04255	COG0191	fructose-bisphosphate aldolase activity
D3W53_RS04260	COG0668	transmembrane transport
D3W53_RS04265	COG1279	arginine transmembrane transporter activity
D3W53_RS04270	COG2968	Membrane
D3W53_RS04275	COG0583	DNA-binding transcription factor activity
D3W53_RS04280	COG0427	acetyl-CoA hydrolase
D3W53_RS04285	COG1024	Enoyl-CoA hydratase
D3W53_RS04290	COG1703	isobutyryl-CoA mutase activity
D3W53_RS04295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3W53_RS04295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3W53_RS04315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3W53_RS04325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3W53_RS04345	COG0006	proline dipeptidase activity
D3W53_RS04350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3W53_RS04355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3W53_RS04375	COG2723	6-phospho-beta-galactosidase activity
D3W53_RS04385	COG1272	protein, Hemolysin III
D3W53_RS04395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D3W53_RS04405	COG0716	FMN binding
D3W53_RS04410	COG4974	Belongs to the 'phage' integrase family
D3W53_RS04415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3W53_RS04420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3W53_RS04430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3W53_RS04445	COG2233	PERMEase
D3W53_RS04450	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS04450	COG0493	'glutamate synthase
D3W53_RS04455	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS04460	COG2252	PERMEase
D3W53_RS04465	COG0402	S-adenosylhomocysteine deaminase activity
D3W53_RS04470	COG2233	PERMEase
D3W53_RS04475	COG2080	2 iron, 2 sulfur cluster binding
D3W53_RS04475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3W53_RS04480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3W53_RS04485	COG0402	S-adenosylhomocysteine deaminase activity
D3W53_RS04490	COG0493	'glutamate synthase
D3W53_RS04490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS04495	COG2068	MobA-Related Protein
D3W53_RS04500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3W53_RS04505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3W53_RS04505	COG3608	succinylglutamate desuccinylase aspartoacylase
D3W53_RS04510	COG0549	Belongs to the carbamate kinase family
D3W53_RS04520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3W53_RS04525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3W53_RS04530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3W53_RS04535	COG3829	transcription factor binding
D3W53_RS04540	COG2080	2 iron, 2 sulfur cluster binding
D3W53_RS04545	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3W53_RS04550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3W53_RS04565	COG4942	peptidase
D3W53_RS04575	COG3387	PFAM Glycoside hydrolase 15-related
D3W53_RS04630	COG1662	PFAM IS1 transposase
D3W53_RS04635	COG1662	PFAM IS1 transposase
D3W53_RS04635	COG3677	Transposase
D3W53_RS04640	COG3710	Transcriptional regulator
D3W53_RS04645	COG2771	luxR family
D3W53_RS04650	COG0814	amino acid
D3W53_RS04655	COG0183	Belongs to the thiolase family
D3W53_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS04670	COG2814	Major facilitator Superfamily
D3W53_RS04675	COG1794	racemase activity, acting on amino acids and derivatives
D3W53_RS04680	COG0583	DNA-binding transcription factor activity
D3W53_RS04690	COG1609	Transcriptional regulator
D3W53_RS04705	COG0667	Aldo Keto reductase
D3W53_RS04715	COG0861	Integral membrane protein TerC family
D3W53_RS04730	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D3W53_RS04745	COG2165	general secretion pathway protein
D3W53_RS04750	COG4795	General secretion pathway protein
D3W53_RS04760	COG4967	type IV pilus modification protein PilV
D3W53_RS04765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D3W53_RS04770	COG1025	Belongs to the peptidase M16 family
D3W53_RS04775	COG1074	ATP-dependent DNA helicase activity
D3W53_RS04780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3W53_RS04785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3W53_RS04785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3W53_RS04795	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3W53_RS04820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3W53_RS04825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D3W53_RS04830	COG2166	iron-sulfur cluster assembly
D3W53_RS04835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3W53_RS04845	COG0583	DNA-binding transcription factor activity
D3W53_RS04850	COG2363	Small membrane protein
D3W53_RS04860	COG1349	DNA-binding transcription factor activity
D3W53_RS04870	COG1070	Carbohydrate kinase
D3W53_RS04880	COG0738	Major facilitator superfamily
D3W53_RS04890	COG1454	alcohol dehydrogenase
D3W53_RS04900	COG1760	l-serine dehydratase
D3W53_RS04905	COG0814	amino acid
D3W53_RS04910	COG1611	Belongs to the LOG family
D3W53_RS04925	COG3098	single-species biofilm formation
D3W53_RS04930	COG0564	pseudouridine synthase activity
D3W53_RS04935	COG0716	FMN binding
D3W53_RS04940	COG2271	Major facilitator Superfamily
D3W53_RS04945	COG4948	Mandelate Racemase Muconate Lactonizing
D3W53_RS04955	COG4999	Histidine kinase
D3W53_RS04955	COG3850	Histidine kinase
D3W53_RS04955	COG3437	response regulator, receiver
D3W53_RS04955	COG2205	protein histidine kinase activity
D3W53_RS04960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3W53_RS04965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3W53_RS04970	COG2336	PFAM SpoVT AbrB
D3W53_RS04975	COG2337	Toxic component of a toxin-antitoxin (TA) module
D3W53_RS04995	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D3W53_RS05005	COG0602	queuosine metabolic process
D3W53_RS05010	COG1070	Carbohydrate kinase
D3W53_RS05015	COG2223	nitrite transmembrane transporter activity
D3W53_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS05025	COG0277	FAD linked oxidase domain protein
D3W53_RS05030	COG0477	Major facilitator Superfamily
D3W53_RS05035	COG2086	electron transfer activity
D3W53_RS05040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3W53_RS05045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D3W53_RS05050	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D3W53_RS05055	COG0644	oxidoreductase
D3W53_RS05060	COG0720	synthase
D3W53_RS05070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3W53_RS05085	COG1203	CRISPR-associated helicase, Cas3
D3W53_RS05100	COG1857	crispr-associated protein
D3W53_RS05115	COG1518	maintenance of DNA repeat elements
D3W53_RS05120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS05125	COG2234	aminopeptidase activity
D3W53_RS05180	COG4942	peptidase
D3W53_RS05180	COG1388	LysM domain
D3W53_RS05185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3W53_RS05190	COG2610	gluconate transmembrane transporter activity
D3W53_RS05195	COG3622	Belongs to the hyi family
D3W53_RS05200	COG0235	Class ii aldolase
D3W53_RS05205	COG3395	kinase activity
D3W53_RS05210	COG2084	Dehydrogenase
D3W53_RS05215	COG1349	DNA-binding transcription factor activity
D3W53_RS05220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3W53_RS05240	COG3604	Transcriptional regulator
D3W53_RS05245	COG0309	Hydrogenase expression formation protein (HypE)
D3W53_RS05250	COG0409	Hydrogenase expression formation protein
D3W53_RS05255	COG0298	carbon dioxide binding
D3W53_RS05260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3W53_RS05265	COG0375	protein maturation
D3W53_RS05275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS05280	COG0651	ATP synthesis coupled electron transport
D3W53_RS05285	COG0650	Formate hydrogenlyase subunit 4
D3W53_RS05290	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D3W53_RS05290	COG3261	NADH dehydrogenase
D3W53_RS05295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3W53_RS05300	COG3260	NADH ubiquinone oxidoreductase 20
D3W53_RS05310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3W53_RS05315	COG2723	6-phospho-beta-galactosidase activity
D3W53_RS05320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS05320	COG1263	PTS System
D3W53_RS05325	COG1609	Transcriptional regulator
D3W53_RS05330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS05335	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D3W53_RS05355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D3W53_RS05355	COG0517	IMP dehydrogenase activity
D3W53_RS05360	COG1349	DNA-binding transcription factor activity
D3W53_RS05365	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS05375	COG3731	PTS system glucitol sorbitol-specific IIA component
D3W53_RS05380	COG3732	PTS system glucitol sorbitol-specific
D3W53_RS05385	COG3730	PTS system glucitol sorbitol-specific
D3W53_RS05390	COG2951	lytic endotransglycosylase activity
D3W53_RS05395	COG1546	Belongs to the CinA family
D3W53_RS05415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D3W53_RS05445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3W53_RS05450	COG1238	metal cluster binding
D3W53_RS05465	COG2814	Major facilitator Superfamily
D3W53_RS05470	COG1566	PFAM secretion protein HlyD family protein
D3W53_RS05475	COG1846	Transcriptional regulator
D3W53_RS05485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3W53_RS05490	COG2814	Major facilitator Superfamily
D3W53_RS05500	COG2113	Glycine betaine
D3W53_RS05505	COG4176	ABC-type proline glycine betaine transport system permease component
D3W53_RS05510	COG4175	Glycine betaine
D3W53_RS05520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3W53_RS05525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3W53_RS05535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3W53_RS05540	COG4575	ribosome binding
D3W53_RS05555	COG2916	Histone family protein nucleoid-structuring protein H-NS
D3W53_RS05560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3W53_RS05565	COG0640	Transcriptional regulator
D3W53_RS05570	COG0401	homolog of Blt101
D3W53_RS05575	COG1652	LysM domain
D3W53_RS05580	COG1802	Transcriptional regulator
D3W53_RS05585	COG1113	amino acid transport
D3W53_RS05590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3W53_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS05600	COG0579	oxidoreductase
D3W53_RS05660	COG1475	DNA binding
D3W53_RS05670	COG0582	viral genome integration into host DNA
D3W53_RS05685	COG2867	negative regulation of translational initiation
D3W53_RS05695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3W53_RS05700	COG0497	DNA recombination
D3W53_RS05720	COG4536	flavin adenine dinucleotide binding
D3W53_RS05725	COG4137	Cytochrome C assembly protein
D3W53_RS05730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3W53_RS05755	COG2885	chlorophyll binding
D3W53_RS05760	COG2199	diguanylate cyclase activity
D3W53_RS05785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3W53_RS05790	COG0287	Prephenate dehydrogenase
D3W53_RS05790	COG1605	Chorismate mutase
D3W53_RS05795	COG0077	Prephenate dehydratase
D3W53_RS05795	COG1605	Chorismate mutase
D3W53_RS05805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3W53_RS05815	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3W53_RS05820	COG0564	pseudouridine synthase activity
D3W53_RS05825	COG1496	oxidoreductase activity
D3W53_RS05830	COG0542	response to heat
D3W53_RS05855	COG0477	Major facilitator Superfamily
D3W53_RS05860	COG5544	Lipoprotein
D3W53_RS05865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3W53_RS05870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3W53_RS05870	COG1042	CoA-binding domain protein
D3W53_RS05870	COG0045	succinate-CoA ligase (ADP-forming) activity
D3W53_RS05875	COG3148	PFAM DTW domain containing protein
D3W53_RS05880	COG3118	belongs to the thioredoxin family
D3W53_RS05890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3W53_RS05910	COG0583	DNA-binding transcription factor activity
D3W53_RS05915	COG0513	Belongs to the DEAD box helicase family
D3W53_RS05925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3W53_RS05930	COG1595	DNA-templated transcription, initiation
D3W53_RS05935	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D3W53_RS05940	COG3026	antisigma factor binding
D3W53_RS05945	COG3086	response to oxidative stress
D3W53_RS05955	COG0681	Belongs to the peptidase S26 family
D3W53_RS05980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3W53_RS06005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS06010	COG1737	Transcriptional regulator
D3W53_RS06015	COG0560	Phosphoserine phosphatase
D3W53_RS06035	COG2205	protein histidine kinase activity
D3W53_RS06040	COG3170	Tfp pilus assembly protein FimV
D3W53_RS06045	COG2204	response regulator
D3W53_RS06050	COG0347	Belongs to the P(II) protein family
D3W53_RS06055	COG1017	nitric oxide dioxygenase activity
D3W53_RS06055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3W53_RS06065	COG1940	carbohydrate kinase activity
D3W53_RS06075	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS06080	COG1129	ABC transporter
D3W53_RS06085	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS06090	COG1063	alcohol dehydrogenase
D3W53_RS06095	COG2017	converts alpha-aldose to the beta-anomer
D3W53_RS06135	COG4638	Rieske (2fe-2S)
D3W53_RS06140	COG0583	DNA-binding transcription factor activity
D3W53_RS06145	COG2814	Major facilitator Superfamily
D3W53_RS06150	COG3711	transcriptional antiterminator
D3W53_RS06155	COG1073	alpha beta
D3W53_RS06160	COG0483	inositol monophosphate 1-phosphatase activity
D3W53_RS06180	COG0822	iron-sulfur transferase activity
D3W53_RS06200	COG0633	Ferredoxin
D3W53_RS06205	COG2975	iron-sulfur cluster assembly
D3W53_RS06220	COG2897	thiosulfate sulfurtransferase activity
D3W53_RS06225	COG2373	Large extracellular alpha-helical protein
D3W53_RS06230	COG4953	penicillin-binding protein 1C
D3W53_RS06265	COG2976	Protein conserved in bacteria
D3W53_RS06280	COG1645	bacterial-type flagellum-dependent swarming motility
D3W53_RS06290	COG0517	IMP dehydrogenase activity
D3W53_RS06290	COG0516	GMP reductase activity
D3W53_RS06305	COG3133	Outer membrane lipoprotein
D3W53_RS06320	COG2200	EAL domain
D3W53_RS06325	COG0248	Ppx GppA phosphatase
D3W53_RS06330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3W53_RS06335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3W53_RS06350	COG2233	PERMEase
D3W53_RS06360	COG1393	Belongs to the ArsC family
D3W53_RS06365	COG4783	chaperone-mediated protein folding
D3W53_RS06370	COG0628	permease
D3W53_RS06380	COG2116	formate transmembrane transporter activity
D3W53_RS06385	COG2116	formate transmembrane transporter activity
D3W53_RS06390	COG3604	Transcriptional regulator
D3W53_RS06400	COG3260	NADH ubiquinone oxidoreductase 20
D3W53_RS06405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3W53_RS06410	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D3W53_RS06410	COG3261	NADH dehydrogenase
D3W53_RS06420	COG4237	Hydrogenase 4 membrane
D3W53_RS06425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3W53_RS06430	COG0650	Formate hydrogenlyase subunit 4
D3W53_RS06440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS06445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3W53_RS06450	COG2716	regulation of RNA biosynthetic process
D3W53_RS06460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D3W53_RS06470	COG2321	neutral zinc metallopeptidase
D3W53_RS06475	COG1444	tRNA N-acetyltransferase activity
D3W53_RS06480	COG0400	carboxylic ester hydrolase activity
D3W53_RS06495	COG1393	Belongs to the ArsC family
D3W53_RS06505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3W53_RS06510	COG3850	Histidine kinase
D3W53_RS06515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS06515	COG0493	'glutamate synthase
D3W53_RS06525	COG5342	invasion associated locus B
D3W53_RS06530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3W53_RS06535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3W53_RS06540	COG0281	malic enzyme
D3W53_RS06540	COG0280	phosphate acetyltransferase
D3W53_RS06545	COG4810	utilization protein
D3W53_RS06550	COG4917	ethanolamine utilization protein
D3W53_RS06555	COG4766	ethanolamine catabolic process
D3W53_RS06560	COG4812	Cobalamin adenosyltransferase
D3W53_RS06565	COG0280	phosphate acetyltransferase
D3W53_RS06570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D3W53_RS06575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
D3W53_RS06580	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS06585	COG4820	ethanolamine utilization protein (EutJ)
D3W53_RS06590	COG1454	alcohol dehydrogenase
D3W53_RS06595	COG3192	ethanolamine utilization protein
D3W53_RS06600	COG4819	ethanolamine utilization protein
D3W53_RS06610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3W53_RS06615	COG0531	amino acid
D3W53_RS06620	COG0076	glutamate decarboxylase activity
D3W53_RS06625	COG0076	glutamate decarboxylase activity
D3W53_RS06680	COG4816	utilization protein
D3W53_RS06685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D3W53_RS06700	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3W53_RS06705	COG0456	acetyltransferase
D3W53_RS06720	COG2837	iron assimilation
D3W53_RS06725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3W53_RS06730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS06730	COG1263	PTS System
D3W53_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS06755	COG4150	thiosulfate binding
D3W53_RS06760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3W53_RS06765	COG4208	sulfate ABC transporter
D3W53_RS06770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D3W53_RS06775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3W53_RS06780	COG3831	ATPase activity
D3W53_RS06780	COG4884	unkown
D3W53_RS06795	COG2190	(PTS) system
D3W53_RS06800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3W53_RS06805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS06810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3W53_RS06830	COG3530	Putative quorum-sensing-regulated virulence factor
D3W53_RS06835	COG0385	Bile acid
D3W53_RS06840	COG0583	DNA-binding transcription factor activity
D3W53_RS06850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3W53_RS06855	COG2211	Major facilitator Superfamily
D3W53_RS06865	COG0583	DNA-binding transcription factor activity
D3W53_RS06900	COG3415	Transposase
D3W53_RS06905	COG3415	Transposase
D3W53_RS06920	COG2200	EAL domain
D3W53_RS06920	COG2199	diguanylate cyclase activity
D3W53_RS06925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3W53_RS06950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS06955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS06960	COG0006	proline dipeptidase activity
D3W53_RS06965	COG1363	Peptidase, m42
D3W53_RS06970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3W53_RS06970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS06970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS06975	COG2207	Transcriptional regulator
D3W53_RS06980	COG3279	Response regulator of the LytR AlgR family
D3W53_RS06985	COG3275	phosphorelay sensor kinase activity
D3W53_RS06990	COG0436	Aminotransferase
D3W53_RS07000	COG1560	Kdo2-lipid A biosynthetic process
D3W53_RS07030	COG0028	Belongs to the TPP enzyme family
D3W53_RS07035	COG0679	Auxin Efflux Carrier
D3W53_RS07040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3W53_RS07045	COG2198	Histidine kinase
D3W53_RS07045	COG0784	Response regulator, receiver
D3W53_RS07045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS07045	COG2205	protein histidine kinase activity
D3W53_RS07050	COG2197	response regulator
D3W53_RS07055	COG1566	PFAM secretion protein HlyD family protein
D3W53_RS07060	COG0477	Major facilitator Superfamily
D3W53_RS07070	COG2610	gluconate transmembrane transporter activity
D3W53_RS07075	COG0583	DNA-binding transcription factor activity
D3W53_RS07130	COG3723	Recombinational DNA repair protein, rece pathway
D3W53_RS07215	COG0582	viral genome integration into host DNA
D3W53_RS07225	COG2116	formate transmembrane transporter activity
D3W53_RS07235	COG2853	Lipoprotein
D3W53_RS07250	COG2067	long-chain fatty acid transport protein
D3W53_RS07255	COG3691	Protein conserved in bacteria
D3W53_RS07270	COG2062	phosphohistidine phosphatase, SixA
D3W53_RS07275	COG3539	Fimbrial protein
D3W53_RS07280	COG3188	usher protein
D3W53_RS07285	COG3121	Chaperone
D3W53_RS07290	COG3539	Fimbrial protein
D3W53_RS07295	COG3539	Fimbrial protein
D3W53_RS07300	COG3539	Fimbrial protein
D3W53_RS07315	COG2890	protein-(glutamine-N5) methyltransferase activity
D3W53_RS07330	COG0730	response to heat
D3W53_RS07335	COG3101	peptidyl-lysine hydroxylation
D3W53_RS07350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3W53_RS07360	COG2814	Major facilitator Superfamily
D3W53_RS07375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3W53_RS07395	COG0285	dihydrofolate synthase activity
D3W53_RS07400	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D3W53_RS07405	COG1286	toxin biosynthetic process
D3W53_RS07410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3W53_RS07415	COG0163	prenyltransferase activity
D3W53_RS07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS07425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS07430	COG4215	(ABC) transporter
D3W53_RS07435	COG4160	amino acid transport
D3W53_RS07440	COG4598	ABC transporter
D3W53_RS07445	COG5464	transposase or invertase
D3W53_RS07450	COG1090	epimerase
D3W53_RS07455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3W53_RS07460	COG0625	glutathione transferase activity
D3W53_RS07465	COG0625	glutathione transferase activity
D3W53_RS07470	COG0622	Phosphoesterase
D3W53_RS07475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D3W53_RS07480	COG1288	antiporter activity
D3W53_RS07485	COG0857	belongs to the CobB CobQ family
D3W53_RS07485	COG0280	phosphate acetyltransferase
D3W53_RS07490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3W53_RS07505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3W53_RS07510	COG0490	domain, Protein
D3W53_RS07510	COG0471	metal ion transport
D3W53_RS07520	COG0436	Aminotransferase
D3W53_RS07530	COG0583	DNA-binding transcription factor activity
D3W53_RS07550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3W53_RS07555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D3W53_RS07560	COG1034	ATP synthesis coupled electron transport
D3W53_RS07575	COG0839	Belongs to the complex I subunit 6 family
D3W53_RS07585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3W53_RS07590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3W53_RS07600	COG0457	Tetratricopeptide repeat
D3W53_RS07640	COG2234	aminopeptidase activity
D3W53_RS07645	COG2304	oxidoreductase activity
D3W53_RS07650	COG5160	protein modification by small protein removal
D3W53_RS07660	COG2153	protein acetylation
D3W53_RS07665	COG4575	ribosome binding
D3W53_RS07670	COG1169	isochorismate synthase
D3W53_RS07685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3W53_RS07695	COG0318	PFAM AMP-dependent synthetase and ligase
D3W53_RS07760	COG1414	Transcriptional regulator
D3W53_RS07770	COG2271	Major facilitator Superfamily
D3W53_RS07785	COG5464	transposase or invertase
D3W53_RS07790	COG0247	lactate metabolic process
D3W53_RS07800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3W53_RS07805	COG2271	Major facilitator Superfamily
D3W53_RS07810	COG0584	glycerophosphoryl diester phosphodiesterase
D3W53_RS07815	COG0583	DNA-binding transcription factor activity
D3W53_RS07820	COG3642	lipopolysaccharide core region biosynthetic process
D3W53_RS07825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3W53_RS07830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3W53_RS07835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3W53_RS07845	COG3468	outer membrane autotransporter barrel domain protein
D3W53_RS07855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3W53_RS07860	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
D3W53_RS07865	COG3234	Protein of unknown function (DUF1175)
D3W53_RS07870	COG2373	Large extracellular alpha-helical protein
D3W53_RS07875	COG5445	Predicted secreted protein (DUF2300)
D3W53_RS07880	COG4676	Protein conserved in bacteria
D3W53_RS07885	COG0183	Belongs to the thiolase family
D3W53_RS07890	COG2031	fatty acid transporter
D3W53_RS07895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D3W53_RS07900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D3W53_RS07905	COG2204	response regulator
D3W53_RS07910	COG3852	Histidine kinase
D3W53_RS07915	COG2205	protein histidine kinase activity
D3W53_RS07915	COG0784	Response regulator, receiver
D3W53_RS07920	COG2197	response regulator
D3W53_RS07925	COG0642	Histidine kinase
D3W53_RS07925	COG2198	Histidine kinase
D3W53_RS07935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3W53_RS07940	COG1477	protein flavinylation
D3W53_RS07945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3W53_RS07945	COG2169	Transcriptional regulator
D3W53_RS07950	COG3145	DNA-N1-methyladenine dioxygenase activity
D3W53_RS07955	COG4615	Cyclic peptide transporter
D3W53_RS07975	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS07975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3W53_RS07980	COG3062	negative regulation of establishment of protein localization
D3W53_RS07990	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS07995	COG0348	domain, Protein
D3W53_RS08000	COG3043	anaerobic respiration
D3W53_RS08005	COG3005	denitrification pathway
D3W53_RS08010	COG4133	protoheme IX ABC transporter activity
D3W53_RS08015	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3W53_RS08020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3W53_RS08025	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3W53_RS08035	COG1138	Cytochrome C-type biogenesis protein
D3W53_RS08040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3W53_RS08045	COG3088	subunit of a heme lyase
D3W53_RS08045	COG4235	cytochrome complex assembly
D3W53_RS08050	COG2197	response regulator
D3W53_RS08055	COG3468	outer membrane autotransporter barrel domain protein
D3W53_RS08070	COG3083	sulfuric ester hydrolase activity
D3W53_RS08090	COG1061	Type III restriction enzyme res subunit
D3W53_RS08095	COG1187	pseudouridine synthase activity
D3W53_RS08100	COG2814	Major facilitator Superfamily
D3W53_RS08115	COG4172	Belongs to the ABC transporter superfamily
D3W53_RS08120	COG4239	(ABC) transporter, permease
D3W53_RS08125	COG4174	ABC transporter (Permease)
D3W53_RS08130	COG4166	transmembrane transport
D3W53_RS08135	COG2200	EAL domain
D3W53_RS08140	COG0791	NLP P60 protein
D3W53_RS08145	COG0671	phosphoesterase, PA-phosphatase related
D3W53_RS08150	COG0523	cobalamin synthesis protein
D3W53_RS08155	COG0246	Mannitol dehydrogenase
D3W53_RS08170	COG2814	Major facilitator Superfamily
D3W53_RS08175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS08175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS08180	COG1105	Belongs to the carbohydrate kinase PfkB family
D3W53_RS08185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS08185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS08185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D3W53_RS08190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS08195	COG2313	pseudouridylate synthase activity
D3W53_RS08200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3W53_RS08205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3W53_RS08215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D3W53_RS08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS08220	COG1522	sequence-specific DNA binding
D3W53_RS08230	COG2855	membrane
D3W53_RS08235	COG0583	DNA-binding transcription factor activity
D3W53_RS08240	COG0833	amino acid
D3W53_RS08250	COG4771	TonB-dependent receptor
D3W53_RS08255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3W53_RS08270	COG2311	Membrane
D3W53_RS08280	COG1609	Transcriptional regulator
D3W53_RS08285	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS08290	COG1129	ABC transporter
D3W53_RS08295	COG4211	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS08300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3W53_RS08300	COG0167	dihydroorotate dehydrogenase activity
D3W53_RS08305	COG0493	'glutamate synthase
D3W53_RS08315	COG2949	membrane
D3W53_RS08325	COG1346	cytolysis
D3W53_RS08335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3W53_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS08365	COG0586	Pfam SNARE associated Golgi protein
D3W53_RS08375	COG1686	Belongs to the peptidase S11 family
D3W53_RS08380	COG0277	FAD linked oxidase domain protein
D3W53_RS08385	COG1472	Belongs to the glycosyl hydrolase 3 family
D3W53_RS08390	COG1732	Glycine betaine
D3W53_RS08395	COG1174	glycine betaine transport
D3W53_RS08400	COG1125	glycine betaine transport
D3W53_RS08405	COG1174	glycine betaine transport
D3W53_RS08415	COG0789	Transcriptional regulator
D3W53_RS08420	COG3275	phosphorelay sensor kinase activity
D3W53_RS08425	COG3279	Response regulator of the LytR AlgR family
D3W53_RS08430	COG4807	Protein conserved in bacteria
D3W53_RS08435	COG4808	Protein conserved in bacteria
D3W53_RS08440	COG4715	Zinc finger, swim domain protein
D3W53_RS08445	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D3W53_RS08455	COG0714	Associated with various cellular activities
D3W53_RS08465	COG3831	ATPase activity
D3W53_RS08480	COG0489	protein tyrosine kinase activity
D3W53_RS08495	COG3539	Fimbrial protein
D3W53_RS08500	COG3121	Chaperone
D3W53_RS08505	COG3188	usher protein
D3W53_RS08510	COG3539	Fimbrial protein
D3W53_RS08515	COG5455	response to cobalt ion
D3W53_RS08535	COG0351	phosphomethylpyrimidine kinase
D3W53_RS08545	COG2188	Transcriptional regulator
D3W53_RS08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS08555	COG1397	ADP-ribosylglycohydrolase
D3W53_RS08560	COG2211	Major facilitator Superfamily
D3W53_RS08565	COG1830	Aldolase
D3W53_RS08575	COG1069	ribulokinase activity
D3W53_RS08600	COG1070	Carbohydrate kinase
D3W53_RS08610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3W53_RS08630	COG0826	peptidase U32
D3W53_RS08640	COG0745	RESPONSE REGULATOR receiver
D3W53_RS08645	COG2205	protein histidine kinase activity
D3W53_RS08685	COG4245	von Willebrand factor, type A
D3W53_RS08690	COG0631	protein serine/threonine phosphatase activity
D3W53_RS08695	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
D3W53_RS08700	COG0443	Heat shock 70 kDa protein
D3W53_RS08710	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D3W53_RS08715	COG5002	protein histidine kinase activity
D3W53_RS08715	COG5001	Diguanylate cyclase
D3W53_RS08715	COG3447	MASE1 domain protein
D3W53_RS08720	COG0572	uridine kinase
D3W53_RS08730	COG2982	Protein involved in outer membrane biogenesis
D3W53_RS08735	COG1253	flavin adenine dinucleotide binding
D3W53_RS08740	COG1596	polysaccharide export
D3W53_RS08745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3W53_RS08750	COG3206	protein involved in exopolysaccharide biosynthesis
D3W53_RS08750	COG0489	protein tyrosine kinase activity
D3W53_RS08755	COG0463	Glycosyl transferase, family 2
D3W53_RS08760	COG1045	serine acetyltransferase
D3W53_RS08765	COG0438	transferase activity, transferring glycosyl groups
D3W53_RS08775	COG1216	Glycosyl transferase, family 2
D3W53_RS08780	COG0110	maltose O-acetyltransferase activity
D3W53_RS08785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3W53_RS08790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3W53_RS08795	COG1051	belongs to the nudix hydrolase family
D3W53_RS08800	COG0297	glycogen (starch) synthase activity
D3W53_RS08805	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D3W53_RS08805	COG0662	Cupin 2, conserved barrel domain protein
D3W53_RS08810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3W53_RS08815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3W53_RS08820	COG2244	polysaccharide biosynthetic process
D3W53_RS08825	COG2327	Polysaccharide pyruvyl transferase
D3W53_RS08830	COG0438	transferase activity, transferring glycosyl groups
D3W53_RS08840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3W53_RS08845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3W53_RS08850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3W53_RS08860	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3W53_RS08865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3W53_RS08870	COG1051	belongs to the nudix hydrolase family
D3W53_RS08875	COG0662	Cupin 2, conserved barrel domain protein
D3W53_RS08875	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D3W53_RS08880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3W53_RS08915	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3W53_RS08920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3W53_RS08925	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D3W53_RS08950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3W53_RS08955	COG0131	Imidazoleglycerol-phosphate dehydratase
D3W53_RS08955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3W53_RS08965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3W53_RS08985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3W53_RS08990	COG0583	DNA-binding transcription factor activity
D3W53_RS09000	COG0531	amino acid
D3W53_RS09005	COG2391	methyltransferase activity
D3W53_RS09010	COG0425	Belongs to the sulfur carrier protein TusA family
D3W53_RS09015	COG2925	Exonuclease
D3W53_RS09020	COG0582	viral genome integration into host DNA
D3W53_RS09040	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3W53_RS09060	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3W53_RS09080	COG1686	Belongs to the peptidase S11 family
D3W53_RS09090	COG1289	transmembrane transporter activity
D3W53_RS09195	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D3W53_RS09210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS09235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3W53_RS09245	COG0583	DNA-binding transcription factor activity
D3W53_RS09260	COG2271	Major facilitator Superfamily
D3W53_RS09270	COG0800	Aldolase
D3W53_RS09275	COG3734	2-keto-3-deoxy-galactonokinase
D3W53_RS09280	COG2186	Transcriptional regulator
D3W53_RS09315	COG0477	Major facilitator Superfamily
D3W53_RS09330	COG1285	pathogenesis
D3W53_RS09350	COG1446	asparaginase
D3W53_RS09370	COG0675	Transposase, IS605 OrfB family
D3W53_RS09375	COG3069	C4-dicarboxylate transmembrane transporter activity
D3W53_RS09380	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3W53_RS09390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3W53_RS09395	COG0252	asparaginase activity
D3W53_RS09400	COG4565	transcriptional regulatory protein
D3W53_RS09405	COG2186	Transcriptional regulator
D3W53_RS09410	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3W53_RS09415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3W53_RS09450	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
D3W53_RS09465	COG1376	ErfK ybiS ycfS ynhG family protein
D3W53_RS09475	COG0583	DNA-binding transcription factor activity
D3W53_RS09480	COG0583	DNA-binding transcription factor activity
D3W53_RS09490	COG0534	Mate efflux family protein
D3W53_RS09505	COG0217	transcriptional regulatory protein
D3W53_RS09510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3W53_RS09515	COG0477	Major facilitator Superfamily
D3W53_RS09525	COG1388	LysM domain
D3W53_RS09525	COG1470	cell adhesion involved in biofilm formation
D3W53_RS09550	COG3038	cytochrome b561
D3W53_RS09555	COG3443	Belongs to the bacterial solute-binding protein 9 family
D3W53_RS09570	COG2351	hydroxyisourate hydrolase activity
D3W53_RS09575	COG0745	RESPONSE REGULATOR receiver
D3W53_RS09580	COG2205	protein histidine kinase activity
D3W53_RS09595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3W53_RS09610	COG1418	mRNA catabolic process
D3W53_RS09615	COG0270	DNA (cytosine-5-)-methyltransferase activity
D3W53_RS09620	COG3727	T/G mismatch-specific endonuclease activity
D3W53_RS09625	COG0697	spore germination
D3W53_RS09630	COG2354	Protein conserved in bacteria
D3W53_RS09635	COG5475	Uncharacterized small protein (DUF2158)
D3W53_RS09665	COG2197	response regulator
D3W53_RS09670	COG1684	flagellar biosynthetic protein fliR
D3W53_RS09675	COG1987	bacterial-type flagellum assembly
D3W53_RS09680	COG1338	Plays a role in the flagellum-specific transport system
D3W53_RS09685	COG3190	flagellar
D3W53_RS09690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3W53_RS09695	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3W53_RS09700	COG1580	Controls the rotational direction of flagella during chemotaxis
D3W53_RS09705	COG3144	bacterial-type flagellum assembly
D3W53_RS09710	COG2882	bacterial-type flagellum organization
D3W53_RS09715	COG1157	protein secretion by the type III secretion system
D3W53_RS09720	COG1317	bacterial-type flagellum organization
D3W53_RS09725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3W53_RS09730	COG1766	The M ring may be actively involved in energy transduction
D3W53_RS09745	COG2135	peptidase activity
D3W53_RS09750	COG0425	Belongs to the sulfur carrier protein TusA family
D3W53_RS09755	COG2391	methyltransferase activity
D3W53_RS09770	COG0366	Alpha amylase catalytic
D3W53_RS09780	COG1516	flagellar protein fliS
D3W53_RS09785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D3W53_RS09790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3W53_RS09795	COG1191	sigma factor activity
D3W53_RS09805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS09815	COG0765	amino acid transport
D3W53_RS09820	COG1126	abc transporter atp-binding protein
D3W53_RS09825	COG2197	response regulator
D3W53_RS09840	COG2197	response regulator
D3W53_RS09905	COG3012	SEC-C Motif Domain Protein
D3W53_RS09905	COG3318	Belongs to the UPF0149 family
D3W53_RS09910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D3W53_RS09955	COG3012	SEC-C Motif Domain Protein
D3W53_RS09955	COG3318	Belongs to the UPF0149 family
D3W53_RS09960	COG0814	amino acid
D3W53_RS09970	COG1528	Iron-storage protein
D3W53_RS09990	COG1528	Iron-storage protein
D3W53_RS10000	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS10005	COG1129	ABC transporter
D3W53_RS10010	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS10015	COG1877	trehalose-phosphatase activity
D3W53_RS10025	COG0589	response to stress
D3W53_RS10040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3W53_RS10045	COG1360	Flagellar Motor Protein
D3W53_RS10050	COG2198	Histidine kinase
D3W53_RS10050	COG0643	Histidine kinase
D3W53_RS10055	COG0835	chemotaxis
D3W53_RS10060	COG0840	transmembrane signaling receptor activity
D3W53_RS10065	COG0840	transmembrane signaling receptor activity
D3W53_RS10070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3W53_RS10075	COG2201	protein-glutamate methylesterase activity
D3W53_RS10080	COG0745	RESPONSE REGULATOR receiver
D3W53_RS10085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D3W53_RS10090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3W53_RS10095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3W53_RS10105	COG3755	Protein conserved in bacteria
D3W53_RS10120	COG3102	Protein conserved in bacteria
D3W53_RS10130	COG3005	denitrification pathway
D3W53_RS10135	COG0243	molybdopterin cofactor binding
D3W53_RS10150	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D3W53_RS10160	COG1335	isochorismatase
D3W53_RS10170	COG0494	nUDIX hydrolase
D3W53_RS10175	COG0217	transcriptional regulatory protein
D3W53_RS10205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3W53_RS10215	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D3W53_RS10220	COG0739	heme binding
D3W53_RS10225	COG1560	Kdo2-lipid A biosynthetic process
D3W53_RS10230	COG0469	pyruvate kinase activity
D3W53_RS10235	COG1737	Transcriptional regulator
D3W53_RS10240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D3W53_RS10245	COG0129	dihydroxy-acid dehydratase activity
D3W53_RS10250	COG0800	Aldolase
D3W53_RS10260	COG3141	response to X-ray
D3W53_RS10270	COG2979	Protein of unknown function (DUF533)
D3W53_RS10275	COG1770	oligopeptidase
D3W53_RS10280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS10285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3W53_RS10295	COG2372	response to copper ion
D3W53_RS10300	COG1276	copper resistance
D3W53_RS10310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3W53_RS10330	COG3008	intermembrane lipid transfer
D3W53_RS10335	COG2995	paraquat-inducible protein a
D3W53_RS10340	COG1956	GAF domain-containing protein
D3W53_RS10350	COG0793	Belongs to the peptidase S41A family
D3W53_RS10360	COG2814	Major facilitator Superfamily
D3W53_RS10365	COG1414	Transcriptional regulator
D3W53_RS10395	COG2226	methyltransferase
D3W53_RS10415	COG3716	PTS system mannose fructose sorbose family IID component
D3W53_RS10420	COG3715	PTS system
D3W53_RS10425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS10425	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS10435	COG1253	flavin adenine dinucleotide binding
D3W53_RS10440	COG2200	EAL domain
D3W53_RS10445	COG1760	l-serine dehydratase
D3W53_RS10455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3W53_RS10470	COG0251	oxidation-reduction process
D3W53_RS10475	COG1199	ATP-dependent helicase activity
D3W53_RS10480	COG1214	PFAM Peptidase M22, glycoprotease
D3W53_RS10485	COG3065	identical protein binding
D3W53_RS10490	COG0318	PFAM AMP-dependent synthetase and ligase
D3W53_RS10495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3W53_RS10500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3W53_RS10505	COG4638	Rieske (2fe-2S)
D3W53_RS10510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3W53_RS10515	COG0473	3-isopropylmalate dehydrogenase activity
D3W53_RS10520	COG0583	DNA-binding transcription factor activity
D3W53_RS10530	COG3615	Tellurite resistance protein tehB
D3W53_RS10550	COG2261	transglycosylase associated protein
D3W53_RS10565	COG2199	diguanylate cyclase activity
D3W53_RS10565	COG2203	Gaf domain
D3W53_RS10570	COG3042	response to heat
D3W53_RS10575	COG3189	MarR family transcriptional regulator
D3W53_RS10580	COG2807	transmembrane transport
D3W53_RS10585	COG2207	Transcriptional regulator
D3W53_RS10600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3W53_RS10605	COG2199	diguanylate cyclase activity
D3W53_RS10610	COG2199	diguanylate cyclase activity
D3W53_RS10620	COG2766	serine protein kinase
D3W53_RS10625	COG3713	MltA-interacting MipA family protein
D3W53_RS10630	COG0656	L-ascorbic acid biosynthetic process
D3W53_RS10635	COG0676	glucose-6-phosphate 1-epimerase activity
D3W53_RS10640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3W53_RS10650	COG3139	Protein of unknown function (DUF1315)
D3W53_RS10655	COG1063	alcohol dehydrogenase
D3W53_RS10660	COG2271	Major facilitator Superfamily
D3W53_RS10670	COG2271	Major facilitator Superfamily
D3W53_RS10675	COG1063	alcohol dehydrogenase
D3W53_RS10680	COG0191	fructose-bisphosphate aldolase activity
D3W53_RS10685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS10690	COG0667	Aldo Keto reductase
D3W53_RS10695	COG1349	DNA-binding transcription factor activity
D3W53_RS10700	COG2814	Major facilitator Superfamily
D3W53_RS10705	COG1335	isochorismatase
D3W53_RS10710	COG0252	asparaginase activity
D3W53_RS10715	COG0616	signal peptide processing
D3W53_RS10725	COG0778	Nitroreductase
D3W53_RS10740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3W53_RS10750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3W53_RS10760	COG0494	nUDIX hydrolase
D3W53_RS10765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3W53_RS10770	COG2897	thiosulfate sulfurtransferase activity
D3W53_RS10775	COG4136	ATPase activity
D3W53_RS10780	COG4135	transport system, permease component
D3W53_RS10785	COG4134	Bacterial extracellular solute-binding protein
D3W53_RS10790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3W53_RS10795	COG0398	Pfam SNARE associated Golgi protein
D3W53_RS10805	COG0398	Pfam SNARE associated Golgi protein
D3W53_RS10810	COG0708	Exodeoxyribonuclease III
D3W53_RS10845	COG3678	ATP-independent chaperone mediated protein folding
D3W53_RS10855	COG0322	excinuclease ABC activity
D3W53_RS10865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3W53_RS10875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D3W53_RS10880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D3W53_RS10895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D3W53_RS10900	COG1447	Phosphotransferase system cellobiose-specific component IIA
D3W53_RS10905	COG2169	Transcriptional regulator
D3W53_RS10905	COG1917	Cupin 2, conserved barrel domain protein
D3W53_RS10910	COG1486	melibiose metabolic process
D3W53_RS10920	COG0753	catalase activity
D3W53_RS10935	COG1823	symporter activity
D3W53_RS10940	COG1988	membrane-bound metal-dependent
D3W53_RS10945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3W53_RS10955	COG3001	Fructosamine kinase
D3W53_RS10965	COG1105	Belongs to the carbohydrate kinase PfkB family
D3W53_RS10970	COG3137	Salt-induced outer membrane protein
D3W53_RS11015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3W53_RS11015	COG0072	phenylalanine-tRNA ligase activity
D3W53_RS11030	COG0386	Belongs to the glutathione peroxidase family
D3W53_RS11040	COG0791	NLP P60 protein
D3W53_RS11045	COG2200	EAL domain
D3W53_RS11055	COG4256	Hemin uptake protein
D3W53_RS11060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3W53_RS11075	COG0574	Belongs to the PEP-utilizing enzyme family
D3W53_RS11075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3W53_RS11080	COG0318	PFAM AMP-dependent synthetase and ligase
D3W53_RS11085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D3W53_RS11090	COG0644	oxidoreductase
D3W53_RS11095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3W53_RS11100	COG2086	electron transfer activity
D3W53_RS11110	COG2207	Transcriptional regulator
D3W53_RS11110	COG1917	Cupin 2, conserved barrel domain protein
D3W53_RS11115	COG1960	acyl-CoA dehydrogenase activity
D3W53_RS11120	COG4670	ketone body catabolic process
D3W53_RS11135	COG2271	Major facilitator Superfamily
D3W53_RS11140	COG0738	Major facilitator superfamily
D3W53_RS11155	COG0628	permease
D3W53_RS11165	COG0247	lactate metabolic process
D3W53_RS11165	COG0277	FAD linked oxidase domain protein
D3W53_RS11170	COG2050	protein possibly involved in aromatic compounds catabolism
D3W53_RS11180	COG0316	Belongs to the HesB IscA family
D3W53_RS11185	COG0719	Fe-S assembly protein
D3W53_RS11190	COG0396	ATPase activity
D3W53_RS11195	COG0719	Fe-S assembly protein
D3W53_RS11210	COG1376	ErfK ybiS ycfS ynhG family protein
D3W53_RS11215	COG4238	major outer membrane lipoprotein
D3W53_RS11220	COG0469	pyruvate kinase activity
D3W53_RS11230	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS11235	COG2414	aldehyde ferredoxin oxidoreductase
D3W53_RS11260	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS11265	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D3W53_RS11275	COG4529	Protein conserved in bacteria
D3W53_RS11295	COG3468	outer membrane autotransporter barrel domain protein
D3W53_RS11305	COG0307	riboflavin synthase, alpha
D3W53_RS11310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3W53_RS11315	COG2814	Major facilitator Superfamily
D3W53_RS11320	COG0583	DNA-binding transcription factor activity
D3W53_RS11335	COG2814	Major facilitator Superfamily
D3W53_RS11340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3W53_RS11345	COG0791	NLP P60 protein
D3W53_RS11350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3W53_RS11355	COG1201	RNA secondary structure unwinding
D3W53_RS11360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS11365	COG0346	lactoylglutathione lyase activity
D3W53_RS11370	COG1902	pentaerythritol trinitrate reductase activity
D3W53_RS11375	COG1309	transcriptional regulator
D3W53_RS11380	COG3313	Fe-S protein
D3W53_RS11385	COG4989	oxidoreductase activity
D3W53_RS11390	COG2032	superoxide dismutase activity
D3W53_RS11395	COG1289	transmembrane transporter activity
D3W53_RS11400	COG1566	PFAM secretion protein HlyD family protein
D3W53_RS11415	COG3133	Outer membrane lipoprotein
D3W53_RS11425	COG3895	Periplasmic Protein
D3W53_RS11440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3W53_RS11445	COG0625	glutathione transferase activity
D3W53_RS11450	COG3104	oligopeptide transport
D3W53_RS11460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3W53_RS11470	COG4659	FMN binding
D3W53_RS11525	COG0673	inositol 2-dehydrogenase activity
D3W53_RS11535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D3W53_RS11540	COG1263	PTS System
D3W53_RS11540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS11545	COG1609	Transcriptional regulator
D3W53_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS11555	COG1309	transcriptional regulator
D3W53_RS11560	COG3250	beta-galactosidase activity
D3W53_RS11585	COG5339	Protein conserved in bacteria
D3W53_RS11590	COG1482	cell wall glycoprotein biosynthetic process
D3W53_RS11595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3W53_RS11595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3W53_RS11600	COG0114	fumarate hydratase activity
D3W53_RS11615	COG0745	RESPONSE REGULATOR receiver
D3W53_RS11620	COG3136	membrane protein required for alginate biosynthesis
D3W53_RS11630	COG0531	amino acid
D3W53_RS11640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3W53_RS11645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3W53_RS11650	COG0628	permease
D3W53_RS11670	COG3591	Belongs to the peptidase S1B family
D3W53_RS11690	COG2814	Major facilitator Superfamily
D3W53_RS11695	COG0583	DNA-binding transcription factor activity
D3W53_RS11700	COG1940	carbohydrate kinase activity
D3W53_RS11705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3W53_RS11715	COG3381	protein complex oligomerization
D3W53_RS11720	COG3302	dmso reductase anchor subunit
D3W53_RS11725	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS11730	COG0243	molybdopterin cofactor binding
D3W53_RS11735	COG0243	molybdopterin cofactor binding
D3W53_RS11750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3W53_RS11770	COG4948	Mandelate Racemase Muconate Lactonizing
D3W53_RS11775	COG1063	alcohol dehydrogenase
D3W53_RS11785	COG0582	viral genome integration into host DNA
D3W53_RS11795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS11870	COG1403	HNH endonuclease
D3W53_RS11885	COG3272	Protein of unknown function (DUF1722)
D3W53_RS11895	COG2207	Transcriptional regulator
D3W53_RS11935	COG1278	Cold shock
D3W53_RS11980	COG5301	cellulose 1,4-beta-cellobiosidase activity
D3W53_RS11985	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3W53_RS11990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3W53_RS12000	COG0477	Major facilitator Superfamily
D3W53_RS12005	COG0246	Mannitol dehydrogenase
D3W53_RS12015	COG1802	Transcriptional regulator
D3W53_RS12020	COG4221	oxidoreductase activity
D3W53_RS12025	COG0339	signal peptide processing
D3W53_RS12030	COG1546	Belongs to the CinA family
D3W53_RS12035	COG3111	PFAM Bacterial OB fold (BOF) protein
D3W53_RS12040	COG3706	GGDEF domain
D3W53_RS12050	COG2814	Major facilitator Superfamily
D3W53_RS12055	COG0697	spore germination
D3W53_RS12065	COG4977	sequence-specific DNA binding
D3W53_RS12070	COG1846	Transcriptional regulator
D3W53_RS12100	COG0583	DNA-binding transcription factor activity
D3W53_RS12105	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS12110	COG2066	Belongs to the glutaminase family
D3W53_RS12125	COG2199	diguanylate cyclase activity
D3W53_RS12135	COG3781	membrane
D3W53_RS12195	COG1396	sequence-specific DNA binding
D3W53_RS12200	COG3550	peptidyl-serine autophosphorylation
D3W53_RS12310	COG3539	Fimbrial protein
D3W53_RS12315	COG3539	Fimbrial protein
D3W53_RS12320	COG3539	Fimbrial protein
D3W53_RS12325	COG0243	molybdopterin cofactor binding
D3W53_RS12335	COG2207	Transcriptional regulator
D3W53_RS12340	COG3119	arylsulfatase activity
D3W53_RS12345	COG0641	radical SAM
D3W53_RS12350	COG4178	(ABC) transporter
D3W53_RS12355	COG4771	TonB-dependent receptor
D3W53_RS12360	COG0612	Peptidase, M16
D3W53_RS12370	COG0076	glutamate decarboxylase activity
D3W53_RS12375	COG0531	amino acid
D3W53_RS12380	COG1649	PFAM Uncharacterised BCR, COG1649
D3W53_RS12390	COG2200	EAL domain
D3W53_RS12390	COG2202	Pas domain
D3W53_RS12390	COG2199	diguanylate cyclase activity
D3W53_RS12395	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3W53_RS12400	COG0747	negative chemotaxis
D3W53_RS12405	COG0601	transmembrane transport
D3W53_RS12410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3W53_RS12415	COG0444	Belongs to the ABC transporter superfamily
D3W53_RS12420	COG4608	Belongs to the ABC transporter superfamily
D3W53_RS12425	COG1764	response to oxidative stress
D3W53_RS12450	COG1064	alcohol dehydrogenase
D3W53_RS12455	COG3093	addiction module antidote protein HigA
D3W53_RS12460	COG2864	formate dehydrogenase
D3W53_RS12465	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS12475	COG0697	spore germination
D3W53_RS12480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3W53_RS12490	COG2223	nitrite transmembrane transporter activity
D3W53_RS12495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D3W53_RS12500	COG1140	nitrate reductase beta subunit
D3W53_RS12505	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D3W53_RS12510	COG2181	nitrate reductase activity
D3W53_RS12515	COG0384	phenazine biosynthesis protein PhzF
D3W53_RS12520	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D3W53_RS12525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3W53_RS12535	COG5433	transposase activity
D3W53_RS12565	COG1113	amino acid transport
D3W53_RS12570	COG3391	amine dehydrogenase activity
D3W53_RS12580	COG4772	TonB-dependent receptor
D3W53_RS12585	COG1802	Transcriptional regulator
D3W53_RS12590	COG2130	NADP-dependent
D3W53_RS12600	COG1247	-acetyltransferase
D3W53_RS12605	COG3238	Protein conserved in bacteria
D3W53_RS12635	COG1177	transmembrane transport
D3W53_RS12640	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3W53_RS12645	COG3842	ATPase activity
D3W53_RS12650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3W53_RS12655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3W53_RS12660	COG1598	PFAM Uncharacterised protein family UPF0150
D3W53_RS12665	COG1724	mRNA binding
D3W53_RS12675	COG0826	peptidase U32
D3W53_RS12680	COG1396	sequence-specific DNA binding
D3W53_RS12685	COG3135	benzoate transporter
D3W53_RS12705	COG0500	methyltransferase
D3W53_RS12710	COG1275	C4-dicarboxylate transporter malic acid transport protein
D3W53_RS12715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3W53_RS12720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3W53_RS12725	COG2841	Protein conserved in bacteria
D3W53_RS12745	COG5383	Protein conserved in bacteria
D3W53_RS12750	COG0583	DNA-binding transcription factor activity
D3W53_RS12755	COG0840	transmembrane signaling receptor activity
D3W53_RS12770	COG3038	cytochrome b561
D3W53_RS12775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3W53_RS12785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3W53_RS12790	COG1643	Atp-dependent helicase
D3W53_RS12800	COG0671	phosphoesterase, PA-phosphatase related
D3W53_RS12800	COG2453	phosphatase
D3W53_RS12805	COG2267	carboxylic ester hydrolase activity
D3W53_RS12825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3W53_RS12835	COG0667	Aldo Keto reductase
D3W53_RS12870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3W53_RS12875	COG3327	negative regulation of DNA-templated transcription, initiation
D3W53_RS12880	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D3W53_RS12885	COG0183	Belongs to the thiolase family
D3W53_RS12890	COG2050	protein possibly involved in aromatic compounds catabolism
D3W53_RS12895	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3W53_RS12900	COG1024	Enoyl-CoA hydratase
D3W53_RS12905	COG1024	Enoyl-CoA hydratase
D3W53_RS12910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3W53_RS12915	COG2151	metal-sulfur cluster biosynthetic enzyme
D3W53_RS12920	COG3396	Phenylacetate-CoA oxygenase
D3W53_RS12925	COG3460	Phenylacetate-CoA oxygenase
D3W53_RS12930	COG3396	Phenylacetate-CoA oxygenase
D3W53_RS12935	COG2030	dehydratase
D3W53_RS12935	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS12940	COG3733	amine oxidase
D3W53_RS12945	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS12950	COG2207	Transcriptional regulator
D3W53_RS12955	COG3784	Protein of unknown function (DUF1318)
D3W53_RS12965	COG2911	Protein conserved in bacteria
D3W53_RS12970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3W53_RS12975	COG3187	Heat shock protein
D3W53_RS12980	COG3042	response to heat
D3W53_RS12985	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3W53_RS12985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3W53_RS12985	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3W53_RS12985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3W53_RS12990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3W53_RS12995	COG0589	response to stress
D3W53_RS13010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3W53_RS13015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3W53_RS13020	COG5301	cellulose 1,4-beta-cellobiosidase activity
D3W53_RS13035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3W53_RS13045	COG3772	lysozyme
D3W53_RS13060	COG3064	Membrane
D3W53_RS13090	COG2814	Major facilitator Superfamily
D3W53_RS13095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3W53_RS13115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3W53_RS13175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS13180	COG3723	Recombinational DNA repair protein, rece pathway
D3W53_RS13210	COG0513	Belongs to the DEAD box helicase family
D3W53_RS13225	COG3706	GGDEF domain
D3W53_RS13230	COG2840	Smr protein MutS2
D3W53_RS13240	COG0583	DNA-binding transcription factor activity
D3W53_RS13245	COG1473	amidohydrolase
D3W53_RS13250	COG1473	amidohydrolase
D3W53_RS13260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D3W53_RS13270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3W53_RS13275	COG0589	response to stress
D3W53_RS13280	COG3182	Iron-regulated membrane protein
D3W53_RS13285	COG0668	transmembrane transport
D3W53_RS13290	COG4166	transmembrane transport
D3W53_RS13295	COG0583	DNA-binding transcription factor activity
D3W53_RS13300	COG1073	alpha beta
D3W53_RS13305	COG0702	epimerase
D3W53_RS13310	COG2866	Carboxypeptidase
D3W53_RS13315	COG4948	Mandelate Racemase Muconate Lactonizing
D3W53_RS13320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D3W53_RS13325	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D3W53_RS13335	COG3106	COG3106 Predicted ATPase
D3W53_RS13340	COG1609	Transcriptional regulator
D3W53_RS13350	COG3842	ATPase activity
D3W53_RS13355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3W53_RS13360	COG1554	hydrolase, family 65, central catalytic
D3W53_RS13365	COG0673	inositol 2-dehydrogenase activity
D3W53_RS13370	COG1082	Xylose isomerase domain protein TIM barrel
D3W53_RS13375	COG1063	alcohol dehydrogenase
D3W53_RS13380	COG0395	ABC-type sugar transport system, permease component
D3W53_RS13385	COG1175	transmembrane transport
D3W53_RS13390	COG1653	transport
D3W53_RS13395	COG0366	Alpha amylase catalytic
D3W53_RS13425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3W53_RS13435	COG1983	PspC domain protein
D3W53_RS13445	COG1842	Phage shock protein A
D3W53_RS13450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3W53_RS13455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3W53_RS13460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3W53_RS13465	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS13470	COG1396	sequence-specific DNA binding
D3W53_RS13470	COG1917	Cupin 2, conserved barrel domain protein
D3W53_RS13475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3W53_RS13480	COG0174	glutamine synthetase
D3W53_RS13485	COG0531	amino acid
D3W53_RS13500	COG4166	transmembrane transport
D3W53_RS13505	COG4168	peptide transport system, permease
D3W53_RS13510	COG4171	peptide transport system, permease
D3W53_RS13515	COG4172	Belongs to the ABC transporter superfamily
D3W53_RS13520	COG4172	Belongs to the ABC transporter superfamily
D3W53_RS13525	COG2852	Protein conserved in bacteria
D3W53_RS13530	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3W53_RS13550	COG5001	Diguanylate cyclase
D3W53_RS13560	COG1349	DNA-binding transcription factor activity
D3W53_RS13570	COG0023	Translation Initiation Factor
D3W53_RS13580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D3W53_RS13585	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D3W53_RS13590	COG0671	phosphoesterase, PA-phosphatase related
D3W53_RS13600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3W53_RS13620	COG0583	DNA-binding transcription factor activity
D3W53_RS13630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3W53_RS13645	COG0616	signal peptide processing
D3W53_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS13655	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D3W53_RS13660	COG1187	pseudouridine synthase activity
D3W53_RS13665	COG4907	membrane protein (DUF2207)
D3W53_RS13670	COG0009	L-threonylcarbamoyladenylate synthase
D3W53_RS13675	COG0613	PHP domain protein
D3W53_RS13685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3W53_RS13690	COG0512	Glutamine amidotransferase of anthranilate synthase
D3W53_RS13690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3W53_RS13710	COG3729	General stress protein
D3W53_RS13715	COG3685	Protein conserved in bacteria
D3W53_RS13720	COG3685	Protein conserved in bacteria
D3W53_RS13725	COG3047	cAMP biosynthetic process
D3W53_RS13745	COG1607	acyl-coa hydrolase
D3W53_RS13750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D3W53_RS13755	COG2350	Protein conserved in bacteria
D3W53_RS13760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3W53_RS13770	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3W53_RS13775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3W53_RS13830	COG4386	tail sheath protein
D3W53_RS13870	COG0616	signal peptide processing
D3W53_RS13915	COG3772	lysozyme
D3W53_RS14060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS14085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3W53_RS14105	COG4608	Belongs to the ABC transporter superfamily
D3W53_RS14110	COG0444	Belongs to the ABC transporter superfamily
D3W53_RS14115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3W53_RS14120	COG0601	transmembrane transport
D3W53_RS14125	COG4166	transmembrane transport
D3W53_RS14135	COG2095	MarC family integral membrane protein
D3W53_RS14140	COG1454	alcohol dehydrogenase
D3W53_RS14140	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS14145	COG1435	thymidine kinase activity
D3W53_RS14155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3W53_RS14160	COG0745	RESPONSE REGULATOR receiver
D3W53_RS14165	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3W53_RS14175	COG0788	formyltetrahydrofolate deformylase activity
D3W53_RS14215	COG2181	nitrate reductase activity
D3W53_RS14220	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D3W53_RS14225	COG1140	nitrate reductase beta subunit
D3W53_RS14230	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D3W53_RS14235	COG2223	nitrite transmembrane transporter activity
D3W53_RS14245	COG3850	Histidine kinase
D3W53_RS14250	COG2197	response regulator
D3W53_RS14255	COG4932	domain protein
D3W53_RS14260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D3W53_RS14265	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3W53_RS14270	COG4572	Cation transport regulator
D3W53_RS14275	COG0387	Pfam Sodium calcium exchanger
D3W53_RS14300	COG2912	Transglutaminase-like superfamily
D3W53_RS14305	COG3094	Invasion gene expression up-regulator, SirB
D3W53_RS14310	COG2890	protein-(glutamine-N5) methyltransferase activity
D3W53_RS14340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3W53_RS14350	COG0659	secondary active sulfate transmembrane transporter activity
D3W53_RS14365	COG0012	GTP binding
D3W53_RS14375	COG3468	outer membrane autotransporter barrel domain protein
D3W53_RS14380	COG3284	Transcriptional regulator
D3W53_RS14385	COG2376	Dihydroxyacetone kinase
D3W53_RS14390	COG1461	Dihydroxyacetone kinase
D3W53_RS14395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS14395	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D3W53_RS14395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3W53_RS14425	COG2261	transglycosylase associated protein
D3W53_RS14430	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D3W53_RS14440	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3W53_RS14455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3W53_RS14465	COG2719	SpoVR family
D3W53_RS14480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D3W53_RS14485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3W53_RS14490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3W53_RS14505	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3W53_RS14530	COG2894	cell division
D3W53_RS14590	COG2200	EAL domain
D3W53_RS14615	COG2200	EAL domain
D3W53_RS14620	COG0789	Transcriptional regulator
D3W53_RS14625	COG5562	phage envelope protein
D3W53_RS14635	COG0538	isocitrate dehydrogenase activity
D3W53_RS14640	COG1187	pseudouridine synthase activity
D3W53_RS14660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3W53_RS14665	COG0745	RESPONSE REGULATOR receiver
D3W53_RS14670	COG2205	protein histidine kinase activity
D3W53_RS14675	COG2850	peptidyl-arginine hydroxylation
D3W53_RS14690	COG3842	ATPase activity
D3W53_RS14700	COG1177	transmembrane transport
D3W53_RS14705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3W53_RS14715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D3W53_RS14720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3W53_RS14730	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3W53_RS14735	COG1136	(ABC) transporter
D3W53_RS14740	COG4591	ABC-type transport system involved in lipoprotein release permease component
D3W53_RS14745	COG4763	Acyl-transferase
D3W53_RS14750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3W53_RS14755	COG1376	ErfK ybiS ycfS ynhG family protein
D3W53_RS14755	COG1388	LysM domain
D3W53_RS14765	COG1309	transcriptional regulator
D3W53_RS14770	COG3134	Outer membrane lipoprotein
D3W53_RS14775	COG1252	NADH dehydrogenase
D3W53_RS14795	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D3W53_RS14800	COG5633	Lipoprotein
D3W53_RS14805	COG0537	adenosine 5'-monophosphoramidase activity
D3W53_RS14810	COG4773	Receptor
D3W53_RS14815	COG1263	PTS System
D3W53_RS14815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS14820	COG0084	hydrolase, TatD family'
D3W53_RS14825	COG0470	DNA polymerase III
D3W53_RS14835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3W53_RS14840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3W53_RS14845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3W53_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS14860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3W53_RS14880	COG1399	metal-binding, possibly nucleic acid-binding protein
D3W53_RS14885	COG0424	maF-like protein
D3W53_RS14890	COG0564	pseudouridine synthase activity
D3W53_RS14900	COG1530	ribonuclease E activity
D3W53_RS14905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3W53_RS14910	COG1256	bacterial-type flagellum assembly
D3W53_RS14915	COG3951	Flagellar rod assembly protein muramidase FlgJ
D3W53_RS14915	COG1705	Flagellar rod assembly protein muramidase FlgJ
D3W53_RS14930	COG4786	Flagellar basal body rod
D3W53_RS14935	COG4787	bacterial-type flagellum-dependent cell motility
D3W53_RS14940	COG1749	Flagellar hook protein flgE
D3W53_RS14945	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3W53_RS14950	COG1558	bacterial-type flagellum-dependent cell motility
D3W53_RS14955	COG1815	bacterial-type flagellum-dependent cell motility
D3W53_RS14960	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D3W53_RS14965	COG2747	anti-sigma28 factor FlgM
D3W53_RS14970	COG3418	PFAM FlgN family protein
D3W53_RS14975	COG0728	peptidoglycan biosynthetic process
D3W53_RS14980	COG0673	inositol 2-dehydrogenase activity
D3W53_RS14990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3W53_RS15000	COG2999	glutathione oxidoreductase activity
D3W53_RS15040	COG3038	cytochrome b561
D3W53_RS15045	COG2353	YceI-like domain
D3W53_RS15055	COG1560	Kdo2-lipid A biosynthetic process
D3W53_RS15070	COG5645	(Lipo)protein
D3W53_RS15075	COG2943	transferase activity, transferring hexosyl groups
D3W53_RS15100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3W53_RS15105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3W53_RS15140	COG2197	response regulator
D3W53_RS15155	COG1462	curli production assembly transport component CsgG
D3W53_RS15165	COG3381	protein complex oligomerization
D3W53_RS15210	COG3658	cytochrome
D3W53_RS15215	COG1702	phosphate starvation-inducible protein PhoH
D3W53_RS15220	COG2837	iron assimilation
D3W53_RS15225	COG2822	iron ion transport
D3W53_RS15240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3W53_RS15255	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D3W53_RS15255	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D3W53_RS15255	COG0506	proline dehydrogenase activity
D3W53_RS15260	COG1309	transcriptional regulator
D3W53_RS15295	COG2233	PERMEase
D3W53_RS15300	COG3729	General stress protein
D3W53_RS15345	COG3381	protein complex oligomerization
D3W53_RS15350	COG0243	molybdopterin cofactor binding
D3W53_RS15355	COG3005	denitrification pathway
D3W53_RS15360	COG0745	RESPONSE REGULATOR receiver
D3W53_RS15365	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS15370	COG2205	protein histidine kinase activity
D3W53_RS15370	COG0784	Response regulator, receiver
D3W53_RS15370	COG2198	Histidine kinase
D3W53_RS15375	COG0348	domain, Protein
D3W53_RS15395	COG1278	Cold shock
D3W53_RS15400	COG1278	Cold shock
D3W53_RS15425	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3W53_RS15435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3W53_RS15440	COG0489	protein tyrosine kinase activity
D3W53_RS15440	COG3206	protein involved in exopolysaccharide biosynthesis
D3W53_RS15455	COG1294	oxidase, subunit
D3W53_RS15460	COG1271	oxidase subunit
D3W53_RS15465	COG1773	rubredoxin
D3W53_RS15470	COG1999	signal sequence binding
D3W53_RS15475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3W53_RS15480	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
D3W53_RS15485	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3W53_RS15490	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3W53_RS15500	COG0670	Belongs to the BI1 family
D3W53_RS15505	COG2920	part of a sulfur-relay system
D3W53_RS15510	COG1254	Belongs to the acylphosphatase family
D3W53_RS15525	COG1832	CoA-binding protein
D3W53_RS15540	COG0210	DNA helicase
D3W53_RS15545	COG3304	Inner membrane component domain
D3W53_RS15550	COG1289	transmembrane transporter activity
D3W53_RS15555	COG3070	regulator of competence-specific genes
D3W53_RS15570	COG2885	chlorophyll binding
D3W53_RS15570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3W53_RS15580	COG1067	ATP-dependent peptidase activity
D3W53_RS15590	COG3130	regulation of translation
D3W53_RS15595	COG3009	Protein conserved in bacteria
D3W53_RS15600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3W53_RS15600	COG3008	intermembrane lipid transfer
D3W53_RS15605	COG2995	paraquat-inducible protein a
D3W53_RS15610	COG0488	(ABC) transporter
D3W53_RS15620	COG0633	Ferredoxin
D3W53_RS15620	COG3217	Mosc domain protein beta barrel domain protein
D3W53_RS15635	COG3121	Chaperone
D3W53_RS15640	COG3539	Fimbrial protein
D3W53_RS15645	COG3539	Fimbrial protein
D3W53_RS15650	COG3539	Fimbrial protein
D3W53_RS15655	COG3188	usher protein
D3W53_RS15660	COG3121	Chaperone
D3W53_RS15665	COG3539	Fimbrial protein
D3W53_RS15675	COG0431	NADPH-dependent FMN reductase
D3W53_RS15680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3W53_RS15690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3W53_RS15695	COG1116	anion transmembrane transporter activity
D3W53_RS15700	COG0308	aminopeptidase N
D3W53_RS15725	COG1448	Aminotransferase
D3W53_RS15730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3W53_RS15735	COG3108	Peptidase M15
D3W53_RS15745	COG2989	Protein conserved in bacteria
D3W53_RS15755	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D3W53_RS15765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3W53_RS15770	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3W53_RS15775	COG3173	Aminoglycoside phosphotransferase
D3W53_RS15790	COG3214	Protein conserved in bacteria
D3W53_RS15795	COG1663	tetraacyldisaccharide 4'-kinase activity
D3W53_RS15800	COG1132	(ABC) transporter
D3W53_RS15805	COG2333	competence protein COMEC
D3W53_RS15805	COG0658	competence protein
D3W53_RS15815	COG0539	negative regulation of cytoplasmic translation
D3W53_RS15825	COG0501	Belongs to the peptidase M48B family
D3W53_RS15840	COG2323	membrane
D3W53_RS15845	COG1944	ATP diphosphatase activity
D3W53_RS15850	COG2116	formate transmembrane transporter activity
D3W53_RS15855	COG1882	Formate acetyltransferase
D3W53_RS15860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3W53_RS15865	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3W53_RS15870	COG0583	DNA-binding transcription factor activity
D3W53_RS15875	COG0531	amino acid
D3W53_RS15885	COG1335	isochorismatase
D3W53_RS15890	COG3302	dmso reductase anchor subunit
D3W53_RS15895	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS15900	COG0243	molybdopterin cofactor binding
D3W53_RS15910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3W53_RS15920	COG1178	ABC-type Fe3 transport system permease component
D3W53_RS15920	COG1674	ftsk spoiiie
D3W53_RS15925	COG1522	sequence-specific DNA binding
D3W53_RS15935	COG0492	ferredoxin-NADP+ reductase activity
D3W53_RS15940	COG4988	ABC transporter
D3W53_RS15945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D3W53_RS15975	COG0542	response to heat
D3W53_RS15985	COG1278	Cold shock
D3W53_RS15990	COG1136	(ABC) transporter
D3W53_RS15990	COG0577	efflux transmembrane transporter activity
D3W53_RS15995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS16000	COG2990	Protein conserved in bacteria
D3W53_RS16005	COG3593	DNA synthesis involved in DNA repair
D3W53_RS16020	COG2431	L-lysine efflux transmembrane transporter activity
D3W53_RS16030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3W53_RS16035	COG0028	Belongs to the TPP enzyme family
D3W53_RS16040	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D3W53_RS16045	COG0702	epimerase
D3W53_RS16050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3W53_RS16055	COG3023	N-Acetylmuramoyl-L-alanine amidase
D3W53_RS16070	COG1126	abc transporter atp-binding protein
D3W53_RS16075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS16080	COG4215	(ABC) transporter
D3W53_RS16085	COG4160	amino acid transport
D3W53_RS16090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS16105	COG1177	transmembrane transport
D3W53_RS16110	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3W53_RS16115	COG3842	ATPase activity
D3W53_RS16120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3W53_RS16135	COG0778	Nitroreductase
D3W53_RS16145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3W53_RS16190	COG4695	Portal protein
D3W53_RS16235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3W53_RS16275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D3W53_RS16280	COG3226	Transcriptional regulator
D3W53_RS16285	COG0738	Major facilitator superfamily
D3W53_RS16290	COG0561	phosphatase activity
D3W53_RS16300	COG2814	Major facilitator Superfamily
D3W53_RS16305	COG0671	phosphoesterase, PA-phosphatase related
D3W53_RS16310	COG1349	DNA-binding transcription factor activity
D3W53_RS16315	COG1686	Belongs to the peptidase S11 family
D3W53_RS16320	COG0625	glutathione transferase activity
D3W53_RS16325	COG2133	pyrroloquinoline quinone binding
D3W53_RS16340	COG2199	diguanylate cyclase activity
D3W53_RS16345	COG2200	EAL domain
D3W53_RS16350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3W53_RS16360	COG0747	negative chemotaxis
D3W53_RS16365	COG4172	Belongs to the ABC transporter superfamily
D3W53_RS16370	COG1446	asparaginase
D3W53_RS16375	COG0303	'Molybdopterin
D3W53_RS16380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3W53_RS16385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3W53_RS16390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3W53_RS16395	COG1882	Formate acetyltransferase
D3W53_RS16400	COG0561	phosphatase activity
D3W53_RS16410	COG0488	(ABC) transporter
D3W53_RS16415	COG1376	ErfK ybiS ycfS ynhG family protein
D3W53_RS16420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3W53_RS16425	COG1321	iron dependent repressor
D3W53_RS16435	COG2194	sulfuric ester hydrolase activity
D3W53_RS16440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3W53_RS16445	COG5006	permease, DMT superfamily
D3W53_RS16470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS16475	COG0765	amino acid transport
D3W53_RS16480	COG1126	abc transporter atp-binding protein
D3W53_RS16485	COG0668	transmembrane transport
D3W53_RS16500	COG4774	siderophore transport
D3W53_RS16510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3W53_RS16520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3W53_RS16525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3W53_RS16530	COG1199	ATP-dependent helicase activity
D3W53_RS16540	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D3W53_RS16545	COG0513	Belongs to the DEAD box helicase family
D3W53_RS16550	COG1309	transcriptional regulator
D3W53_RS16560	COG1131	(ABC) transporter
D3W53_RS16565	COG0842	Transport permease protein
D3W53_RS16570	COG0842	Transport permease protein
D3W53_RS16580	COG3568	Endonuclease Exonuclease Phosphatase
D3W53_RS16585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3W53_RS16590	COG0392	lysyltransferase activity
D3W53_RS16595	COG0670	Belongs to the BI1 family
D3W53_RS16600	COG0670	Belongs to the BI1 family
D3W53_RS16605	COG0314	molybdopterin synthase activity
D3W53_RS16610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3W53_RS16620	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3W53_RS16630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3W53_RS16640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3W53_RS16645	COG2226	methyltransferase
D3W53_RS16660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3W53_RS16665	COG1881	PFAM PEBP family protein
D3W53_RS16675	COG4677	pectinesterase activity
D3W53_RS16685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3W53_RS16705	COG0583	DNA-binding transcription factor activity
D3W53_RS16715	COG0561	phosphatase activity
D3W53_RS16720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3W53_RS16725	COG4149	molybdate abc transporter
D3W53_RS16730	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3W53_RS16740	COG3585	molybdate ion transport
D3W53_RS16740	COG2005	Transcriptional regulator
D3W53_RS16745	COG1119	ATPase activity
D3W53_RS16750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3W53_RS16755	COG1085	galactose-1-phosphate uridylyltransferase
D3W53_RS16765	COG2017	converts alpha-aldose to the beta-anomer
D3W53_RS16775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3W53_RS16790	COG1230	cation diffusion facilitator family transporter
D3W53_RS16795	COG3201	nicotinamide mononucleotide transporter
D3W53_RS16840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D3W53_RS16845	COG2885	chlorophyll binding
D3W53_RS16855	COG3064	Membrane
D3W53_RS16860	COG0848	biopolymer transport protein
D3W53_RS16865	COG0811	peptide transport
D3W53_RS16870	COG0824	Thioesterase
D3W53_RS16875	COG3790	cyd operon protein YbgE
D3W53_RS16880	COG4890	Cyd operon protein YbgT
D3W53_RS16885	COG1294	oxidase, subunit
D3W53_RS16890	COG1271	oxidase subunit
D3W53_RS16900	COG0383	alpha-mannosidase activity
D3W53_RS16905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS16905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS16905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS16910	COG2188	Transcriptional regulator
D3W53_RS16915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3W53_RS16925	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3W53_RS16930	COG0567	Dehydrogenase, E1 component
D3W53_RS16935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3W53_RS16940	COG1053	succinate dehydrogenase
D3W53_RS16945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D3W53_RS16950	COG2009	succinate dehydrogenase
D3W53_RS16960	COG0372	Belongs to the citrate synthase family
D3W53_RS16965	COG3539	Fimbrial protein
D3W53_RS16970	COG3188	usher protein
D3W53_RS16975	COG3121	Chaperone
D3W53_RS16980	COG3539	Fimbrial protein
D3W53_RS16985	COG3180	Ammonia monooxygenase
D3W53_RS17000	COG1984	allophanate hydrolase subunit 2
D3W53_RS17005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3W53_RS17010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3W53_RS17015	COG3104	oligopeptide transport
D3W53_RS17020	COG0415	Belongs to the DNA photolyase family
D3W53_RS17025	COG3272	Protein of unknown function (DUF1722)
D3W53_RS17050	COG3209	COG3209 Rhs family protein
D3W53_RS17080	COG2205	protein histidine kinase activity
D3W53_RS17085	COG0745	RESPONSE REGULATOR receiver
D3W53_RS17095	COG1982	Orn Lys Arg decarboxylase major
D3W53_RS17100	COG0531	amino acid
D3W53_RS17120	COG0033	Phosphoglucomutase
D3W53_RS17125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D3W53_RS17130	COG0596	Alpha beta hydrolase
D3W53_RS17140	COG0716	FMN binding
D3W53_RS17150	COG0735	belongs to the Fur family
D3W53_RS17180	COG1263	PTS System
D3W53_RS17180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS17180	COG2190	(PTS) system
D3W53_RS17190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3W53_RS17195	COG1846	Transcriptional regulator
D3W53_RS17195	COG1940	carbohydrate kinase activity
D3W53_RS17200	COG0647	UMP catabolic process
D3W53_RS17205	COG0367	asparagine synthase
D3W53_RS17250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3W53_RS17260	COG1702	phosphate starvation-inducible protein PhoH
D3W53_RS17270	COG4535	Mg2 and Co2 transporter CorC
D3W53_RS17275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3W53_RS17280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3W53_RS17285	COG0765	amino acid transport
D3W53_RS17290	COG0765	amino acid transport
D3W53_RS17295	COG1126	abc transporter atp-binding protein
D3W53_RS17305	COG0443	Heat shock 70 kDa protein
D3W53_RS17310	COG2214	Heat shock protein DnaJ domain protein
D3W53_RS17320	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D3W53_RS17335	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D3W53_RS17340	COG2888	peptidyl-tyrosine sulfation
D3W53_RS17355	COG1466	dna polymerase III delta subunit
D3W53_RS17365	COG0406	alpha-ribazole phosphatase activity
D3W53_RS17370	COG0799	negative regulation of ribosome biogenesis
D3W53_RS17380	COG0768	penicillin binding
D3W53_RS17385	COG0772	Belongs to the SEDS family
D3W53_RS17390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3W53_RS17395	COG1686	Belongs to the peptidase S11 family
D3W53_RS17415	COG0583	DNA-binding transcription factor activity
D3W53_RS17425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3W53_RS17430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3W53_RS17455	COG3069	C4-dicarboxylate transmembrane transporter activity
D3W53_RS17460	COG4565	transcriptional regulatory protein
D3W53_RS17465	COG3290	protein histidine kinase activity
D3W53_RS17470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D3W53_RS17480	COG2301	Belongs to the HpcH HpaI aldolase family
D3W53_RS17485	COG3051	citrate lyase alpha subunit
D3W53_RS17500	COG0471	metal ion transport
D3W53_RS17505	COG3719	Belongs to the RNase T2 family
D3W53_RS17515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3W53_RS17525	COG1063	alcohol dehydrogenase
D3W53_RS17530	COG0589	response to stress
D3W53_RS17535	COG3634	alkyl hydroperoxide reductase activity
D3W53_RS17540	COG0450	alkyl hydroperoxide reductase
D3W53_RS17545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3W53_RS17555	COG0583	DNA-binding transcription factor activity
D3W53_RS17560	COG3969	phosphoadenosine phosphosulfate
D3W53_RS17565	COG1475	DNA binding
D3W53_RS17570	COG0436	Aminotransferase
D3W53_RS17575	COG0371	Dehydrogenase
D3W53_RS17580	COG2879	small protein
D3W53_RS17585	COG1966	Carbon starvation protein
D3W53_RS17590	COG2050	protein possibly involved in aromatic compounds catabolism
D3W53_RS17595	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS17600	COG3433	isochorismatase activity
D3W53_RS17600	COG1535	isochorismatase
D3W53_RS17605	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3W53_RS17610	COG1169	isochorismate synthase
D3W53_RS17615	COG4592	Periplasmic binding protein
D3W53_RS17625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3W53_RS17630	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3W53_RS17635	COG1120	ATPase activity
D3W53_RS17640	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D3W53_RS17645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3W53_RS17645	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D3W53_RS17650	COG3251	PFAM MbtH domain protein
D3W53_RS17655	COG2382	esterase
D3W53_RS17660	COG4771	TonB-dependent receptor
D3W53_RS17665	COG2977	Belongs to the P-Pant transferase superfamily
D3W53_RS17700	COG2315	Protein conserved in bacteria
D3W53_RS17705	COG0778	Nitroreductase
D3W53_RS17710	COG0668	transmembrane transport
D3W53_RS17715	COG1113	amino acid transport
D3W53_RS17720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3W53_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS17730	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS17735	COG1538	Outer membrane efflux protein
D3W53_RS17740	COG0745	RESPONSE REGULATOR receiver
D3W53_RS17745	COG5002	protein histidine kinase activity
D3W53_RS17765	COG3209	COG3209 Rhs family protein
D3W53_RS17765	COG4104	PAAR repeat-containing protein
D3W53_RS17770	COG4104	PAAR repeat-containing protein
D3W53_RS17770	COG3209	COG3209 Rhs family protein
D3W53_RS17790	COG5433	transposase activity
D3W53_RS17795	COG1215	transferase activity, transferring glycosyl groups
D3W53_RS17815	COG2207	Transcriptional regulator
D3W53_RS17830	COG4571	Outer membrane protease
D3W53_RS17860	COG5301	cellulose 1,4-beta-cellobiosidase activity
D3W53_RS17880	COG5562	phage envelope protein
D3W53_RS17900	COG3772	lysozyme
D3W53_RS17935	COG0582	viral genome integration into host DNA
D3W53_RS17945	COG2197	response regulator
D3W53_RS17950	COG3539	Fimbrial protein
D3W53_RS17955	COG3539	Fimbrial protein
D3W53_RS17960	COG3188	usher protein
D3W53_RS17965	COG3121	Chaperone
D3W53_RS17970	COG3539	Fimbrial protein
D3W53_RS17980	COG2501	S4 domain
D3W53_RS17985	COG1988	membrane-bound metal-dependent
D3W53_RS17995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3W53_RS18010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3W53_RS18015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3W53_RS18020	COG0549	Belongs to the carbamate kinase family
D3W53_RS18030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3W53_RS18035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3W53_RS18040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3W53_RS18045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3W53_RS18050	COG3257	ureidoglycine aminohydrolase activity
D3W53_RS18055	COG1929	Belongs to the glycerate kinase type-1 family
D3W53_RS18060	COG2233	PERMEase
D3W53_RS18070	COG1953	Uracil, thiamine, allantoin
D3W53_RS18075	COG2084	Dehydrogenase
D3W53_RS18080	COG3622	Belongs to the hyi family
D3W53_RS18085	COG3960	tartronate-semialdehyde synthase activity
D3W53_RS18090	COG1414	Transcriptional regulator
D3W53_RS18100	COG0583	DNA-binding transcription factor activity
D3W53_RS18130	COG3209	COG3209 Rhs family protein
D3W53_RS18135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D3W53_RS18140	COG4181	ATPase activity
D3W53_RS18145	COG2755	lipolytic protein G-D-S-L family
D3W53_RS18150	COG0300	oxidoreductase activity
D3W53_RS18155	COG3118	belongs to the thioredoxin family
D3W53_RS18160	COG0390	transport system, permease component
D3W53_RS18165	COG4619	ABC transporter
D3W53_RS18170	COG0330	HflC and HflK could
D3W53_RS18175	COG1585	Membrane protein implicated in regulation of membrane protease activity
D3W53_RS18180	COG0789	Transcriptional regulator
D3W53_RS18185	COG0531	amino acid
D3W53_RS18190	COG2066	Belongs to the glutaminase family
D3W53_RS18195	COG2217	Heavy metal translocating P-type atpase
D3W53_RS18200	COG3093	addiction module antidote protein HigA
D3W53_RS18210	COG3735	TraB family
D3W53_RS18220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3W53_RS18225	COG0737	Belongs to the 5'-nucleotidase family
D3W53_RS18230	COG2223	nitrite transmembrane transporter activity
D3W53_RS18235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3W53_RS18235	COG4651	solute:proton antiporter activity
D3W53_RS18240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS18280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D3W53_RS18290	COG2832	Protein of unknown function (DUF454)
D3W53_RS18295	COG3923	Primosomal replication protein n
D3W53_RS18305	COG3264	Mechanosensitive ion channel
D3W53_RS18305	COG1196	nuclear chromosome segregation
D3W53_RS18315	COG1309	transcriptional regulator
D3W53_RS18320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3W53_RS18325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3W53_RS18340	COG0110	maltose O-acetyltransferase activity
D3W53_RS18350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D3W53_RS18355	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3W53_RS18365	COG3695	enzyme binding
D3W53_RS18370	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D3W53_RS18375	COG1946	Acyl-CoA thioesterase
D3W53_RS18380	COG0004	ammonium transporteR
D3W53_RS18385	COG0347	Belongs to the P(II) protein family
D3W53_RS18390	COG1132	(ABC) transporter
D3W53_RS18395	COG1132	(ABC) transporter
D3W53_RS18400	COG1522	sequence-specific DNA binding
D3W53_RS18410	COG4533	DNA binding
D3W53_RS18420	COG0824	Thioesterase
D3W53_RS18425	COG1555	photosystem II stabilization
D3W53_RS18430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3W53_RS18435	COG0776	regulation of translation
D3W53_RS18440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3W53_RS18465	COG0271	Belongs to the BolA IbaG family
D3W53_RS18470	COG3056	Lipoprotein
D3W53_RS18475	COG2223	nitrite transmembrane transporter activity
D3W53_RS18480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3W53_RS18485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3W53_RS18490	COG1845	cytochrome c oxidase, subunit III
D3W53_RS18495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D3W53_RS18505	COG2814	Major facilitator Superfamily
D3W53_RS18515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3W53_RS18520	COG0693	protein deglycase activity
D3W53_RS18535	COG0142	geranyltranstransferase activity
D3W53_RS18545	COG0667	Aldo Keto reductase
D3W53_RS18550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D3W53_RS18555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3W53_RS18570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3W53_RS18570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3W53_RS18580	COG4238	major outer membrane lipoprotein
D3W53_RS18585	COG3248	Nucleoside-binding outer membrane protein
D3W53_RS18590	COG1403	HNH endonuclease
D3W53_RS18595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3W53_RS18600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3W53_RS18605	COG1862	Preprotein translocase
D3W53_RS18625	COG0366	Alpha amylase catalytic
D3W53_RS18630	COG1113	amino acid transport
D3W53_RS18635	COG1114	Component of the transport system for branched-chain amino acids
D3W53_RS18640	COG5002	protein histidine kinase activity
D3W53_RS18645	COG0745	RESPONSE REGULATOR receiver
D3W53_RS18650	COG0420	3'-5' exonuclease activity
D3W53_RS18655	COG0419	ATPase involved in DNA repair
D3W53_RS18660	COG2814	Major facilitator Superfamily
D3W53_RS18665	COG1940	carbohydrate kinase activity
D3W53_RS18690	COG4126	flavin adenine dinucleotide binding
D3W53_RS18710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3W53_RS18715	COG3706	GGDEF domain
D3W53_RS18725	COG1785	Belongs to the alkaline phosphatase family
D3W53_RS18735	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3W53_RS18760	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D3W53_RS18770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3W53_RS18775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3W53_RS18780	COG3468	outer membrane autotransporter barrel domain protein
D3W53_RS18785	COG0113	porphobilinogen synthase activity
D3W53_RS18790	COG2175	clavaminate synthase activity
D3W53_RS18795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3W53_RS18800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3W53_RS18805	COG4521	taurine ABC transporter
D3W53_RS18810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3W53_RS18815	COG1215	transferase activity, transferring glycosyl groups
D3W53_RS18850	COG3122	Protein conserved in bacteria
D3W53_RS18855	COG2814	Major facilitator Superfamily
D3W53_RS18870	COG3971	2-oxopent-4-enoate hydratase activity
D3W53_RS18890	COG1414	Transcriptional regulator
D3W53_RS18895	COG1609	Transcriptional regulator
D3W53_RS18905	COG3250	beta-galactosidase activity
D3W53_RS18910	COG2223	nitrite transmembrane transporter activity
D3W53_RS18915	COG0110	maltose O-acetyltransferase activity
D3W53_RS18920	COG2807	transmembrane transport
D3W53_RS18930	COG0288	reversible hydration of carbon dioxide
D3W53_RS18935	COG0583	DNA-binding transcription factor activity
D3W53_RS18940	COG0402	S-adenosylhomocysteine deaminase activity
D3W53_RS18945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D3W53_RS18950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3W53_RS18955	COG2079	MmgE PrpD family protein
D3W53_RS18960	COG0372	Belongs to the citrate synthase family
D3W53_RS18965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3W53_RS18970	COG3829	transcription factor binding
D3W53_RS18980	COG1280	lysine exporter protein (LysE YggA)
D3W53_RS18995	COG1064	alcohol dehydrogenase
D3W53_RS19000	COG0402	S-adenosylhomocysteine deaminase activity
D3W53_RS19015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3W53_RS19025	COG0666	response to abiotic stimulus
D3W53_RS19040	COG0583	DNA-binding transcription factor activity
D3W53_RS19045	COG2771	luxR family
D3W53_RS19045	COG2200	EAL domain
D3W53_RS19055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D3W53_RS19095	COG1556	Lactate utilization protein
D3W53_RS19100	COG1139	Iron-sulfur cluster binding protein
D3W53_RS19105	COG0247	lactate metabolic process
D3W53_RS19110	COG2207	Transcriptional regulator
D3W53_RS19115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3W53_RS19125	COG3059	membrane
D3W53_RS19130	COG2207	Transcriptional regulator
D3W53_RS19130	COG3708	Transcriptional regulator
D3W53_RS19145	COG1388	LysM domain
D3W53_RS19195	COG3188	usher protein
D3W53_RS19205	COG3121	Chaperone
D3W53_RS19210	COG0727	PFAM Uncharacterised protein family (UPF0153)
D3W53_RS19225	COG2080	2 iron, 2 sulfur cluster binding
D3W53_RS19230	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3W53_RS19235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3W53_RS19245	COG0583	DNA-binding transcription factor activity
D3W53_RS19305	COG1874	Beta-galactosidase
D3W53_RS19310	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D3W53_RS19315	COG3833	ABC-type maltose transport systems, permease component
D3W53_RS19320	COG1175	transmembrane transport
D3W53_RS19325	COG2182	Extracellular solute-binding protein
D3W53_RS19360	COG4983	Phage plasmid primase, P4 family domain protein
D3W53_RS19405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D3W53_RS19425	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3W53_RS19430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D3W53_RS19435	COG1690	Belongs to the RtcB family
D3W53_RS19440	COG0454	-acetyltransferase
D3W53_RS19450	COG2161	toxin-antitoxin pair type II binding
D3W53_RS19470	COG1943	Transposase
D3W53_RS19480	COG3077	Addiction module antitoxin, RelB DinJ family
D3W53_RS19485	COG3041	Addiction module toxin RelE StbE family
D3W53_RS19490	COG3034	peptidoglycan biosynthetic process
D3W53_RS19495	COG0121	glutamine amidotransferase
D3W53_RS19505	COG1960	acyl-CoA dehydrogenase activity
D3W53_RS19515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3W53_RS19545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3W53_RS19555	COG2226	methyltransferase
D3W53_RS19565	COG0741	lytic transglycosylase activity
D3W53_RS19565	COG1388	LysM domain
D3W53_RS19570	COG2226	methyltransferase
D3W53_RS19580	COG0583	DNA-binding transcription factor activity
D3W53_RS19585	COG0656	L-ascorbic acid biosynthetic process
D3W53_RS19620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3W53_RS19625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3W53_RS19630	COG2011	ABC-type metal ion transport system permease component
D3W53_RS19635	COG1464	Belongs to the NlpA lipoprotein family
D3W53_RS19645	COG1720	tRNA m6t6A37 methyltransferase activity
D3W53_RS19655	COG0791	NLP P60 protein
D3W53_RS19660	COG3015	lipoprotein NlpE involved in copper resistance
D3W53_RS19665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D3W53_RS19670	COG4681	YaeQ
D3W53_RS19680	COG4568	rho-dependent transcription termination
D3W53_RS19690	COG0346	lactoylglutathione lyase activity
D3W53_RS19695	COG1982	Orn Lys Arg decarboxylase major
D3W53_RS19705	COG0587	DNA-directed DNA polymerase activity
D3W53_RS19730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3W53_RS19735	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D3W53_RS19745	COG0750	zinc metalloprotease
D3W53_RS19750	COG0575	Belongs to the CDS family
D3W53_RS19755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3W53_RS19760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3W53_RS19790	COG0024	Methionine aminopeptidase
D3W53_RS19805	COG1408	metallophosphoesterase
D3W53_RS19815	COG3835	regulator
D3W53_RS19820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3W53_RS19840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3W53_RS19845	COG2860	membrane
D3W53_RS19865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3W53_RS19870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3W53_RS19875	COG1120	ATPase activity
D3W53_RS19880	COG4774	siderophore transport
D3W53_RS19885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3W53_RS19895	COG1643	Atp-dependent helicase
D3W53_RS19900	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D3W53_RS19910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3W53_RS19920	COG0617	tRNA 3'-terminal CCA addition
D3W53_RS19925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3W53_RS19955	COG5464	transposase or invertase
D3W53_RS19970	COG0726	polysaccharide deacetylase
D3W53_RS19975	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS19980	COG0842	Transport permease protein
D3W53_RS19985	COG1131	(ABC) transporter
D3W53_RS19990	COG0288	reversible hydration of carbon dioxide
D3W53_RS19995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D3W53_RS20000	COG4993	Dehydrogenase
D3W53_RS20005	COG2132	Multicopper oxidase
D3W53_RS20030	COG1049	propionate catabolic process, 2-methylcitrate cycle
D3W53_RS20040	COG3064	Membrane
D3W53_RS20045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3W53_RS20050	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3W53_RS20055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D3W53_RS20060	COG2186	Transcriptional regulator
D3W53_RS20070	COG3725	Membrane protein required for beta-lactamase induction
D3W53_RS20075	COG3023	N-Acetylmuramoyl-L-alanine amidase
D3W53_RS20080	COG0157	Belongs to the NadC ModD family
D3W53_RS20090	COG4969	Belongs to the N-Me-Phe pilin family
D3W53_RS20095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3W53_RS20100	COG1459	type II secretion system
D3W53_RS20110	COG0237	dephospho-CoA kinase activity
D3W53_RS20125	COG0494	nUDIX hydrolase
D3W53_RS20145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3W53_RS20150	COG0849	cell division
D3W53_RS20155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3W53_RS20160	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3W53_RS20175	COG0772	Belongs to the SEDS family
D3W53_RS20180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3W53_RS20190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3W53_RS20195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3W53_RS20200	COG0768	penicillin binding
D3W53_RS20205	COG3116	cell division
D3W53_RS20225	COG1609	Transcriptional regulator
D3W53_RS20235	COG0440	acetolactate synthase activity
D3W53_RS20240	COG0028	Belongs to the TPP enzyme family
D3W53_RS20245	COG0583	DNA-binding transcription factor activity
D3W53_RS20260	COG0473	3-isopropylmalate dehydrogenase activity
D3W53_RS20275	COG2814	Major facilitator Superfamily
D3W53_RS20285	COG4533	DNA binding
D3W53_RS20290	COG4143	(ABC) transporter
D3W53_RS20295	COG1178	ABC-type Fe3 transport system permease component
D3W53_RS20305	COG0586	Pfam SNARE associated Golgi protein
D3W53_RS20310	COG4977	sequence-specific DNA binding
D3W53_RS20330	COG0235	Class ii aldolase
D3W53_RS20335	COG0417	DNA replication proofreading
D3W53_RS20345	COG0564	pseudouridine synthase activity
D3W53_RS20350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3W53_RS20355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3W53_RS20360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3W53_RS20400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3W53_RS20415	COG2271	Major facilitator Superfamily
D3W53_RS20420	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D3W53_RS20425	COG0644	oxidoreductase
D3W53_RS20475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3W53_RS20480	COG0505	Belongs to the CarA family
D3W53_RS20500	COG1047	Peptidyl-prolyl cis-trans
D3W53_RS20515	COG0196	riboflavin kinase activity
D3W53_RS20550	COG0583	DNA-binding transcription factor activity
D3W53_RS20565	COG3385	transposase activity
D3W53_RS20585	COG4735	regulation of single-species biofilm formation
D3W53_RS20590	COG1584	GPR1 FUN34 yaaH family protein
D3W53_RS20595	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3W53_RS20605	COG1115	amino acid carrier protein
D3W53_RS20620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3W53_RS20630	COG0527	aspartate kinase activity
D3W53_RS20630	COG0460	homoserine dehydrogenase
D3W53_RS20640	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D3W53_RS20650	COG0745	RESPONSE REGULATOR receiver
D3W53_RS20655	COG4452	Inner membrane protein CreD
D3W53_RS20660	COG2205	protein histidine kinase activity
D3W53_RS20665	COG0745	RESPONSE REGULATOR receiver
D3W53_RS20670	COG3045	CreA protein
D3W53_RS20675	COG3708	Transcriptional regulator
D3W53_RS20675	COG2207	Transcriptional regulator
D3W53_RS20695	COG0741	lytic transglycosylase activity
D3W53_RS20700	COG0488	(ABC) transporter
D3W53_RS20705	COG3172	ATPase kinase involved in NAD metabolism
D3W53_RS20705	COG1056	cytidyltransferase-related domain
D3W53_RS20710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3W53_RS20715	COG0560	Phosphoserine phosphatase
D3W53_RS20720	COG3726	membrane protein affecting hemolysin expression
D3W53_RS20750	COG1328	CTP reductase activity
D3W53_RS20755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3W53_RS20760	COG0084	hydrolase, TatD family'
D3W53_RS20765	COG4667	esterase of the alpha-beta hydrolase superfamily
D3W53_RS20775	COG2823	Periplasmic or secreted lipoprotein
D3W53_RS20785	COG1011	Hydrolase
D3W53_RS20790	COG0456	acetyltransferase
D3W53_RS20795	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D3W53_RS20825	COG4114	ferric iron reductase
D3W53_RS20830	COG2197	response regulator
D3W53_RS20835	COG2197	response regulator
D3W53_RS20840	COG2966	Psort location CytoplasmicMembrane, score
D3W53_RS20855	COG1484	DNA-dependent DNA replication
D3W53_RS20870	COG1063	alcohol dehydrogenase
D3W53_RS20875	COG1802	Transcriptional regulator
D3W53_RS20885	COG0840	transmembrane signaling receptor activity
D3W53_RS20890	COG1846	Transcriptional regulator
D3W53_RS20895	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3W53_RS20900	COG1012	belongs to the aldehyde dehydrogenase family
D3W53_RS20905	COG3384	dioxygenase
D3W53_RS20915	COG3971	2-oxopent-4-enoate hydratase activity
D3W53_RS20935	COG2368	4-hydroxyphenylacetate
D3W53_RS20940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3W53_RS20950	COG1966	Carbon starvation protein
D3W53_RS20955	COG2879	small protein
D3W53_RS20960	COG0523	cobalamin synthesis protein
D3W53_RS20980	COG5457	Domain of unknown function (DUF1127)
D3W53_RS20985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3W53_RS21000	COG2733	membrane
D3W53_RS21010	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
D3W53_RS21015	COG1924	4 iron, 4 sulfur cluster binding
D3W53_RS21030	COG0477	Major facilitator Superfamily
D3W53_RS21040	COG3366	ferrous iron transmembrane transporter activity
D3W53_RS21045	COG0700	Nucleoside recognition
D3W53_RS21050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3W53_RS21055	COG0583	DNA-binding transcription factor activity
D3W53_RS21075	COG2186	Transcriptional regulator
D3W53_RS21085	COG0246	Mannitol dehydrogenase
D3W53_RS21105	COG3539	Fimbrial protein
D3W53_RS21110	COG3539	Fimbrial protein
D3W53_RS21140	COG1064	alcohol dehydrogenase
D3W53_RS21145	COG0433	COG0433 Predicted ATPase
D3W53_RS21150	COG0795	lipopolysaccharide-transporting ATPase activity
D3W53_RS21155	COG0795	lipopolysaccharide-transporting ATPase activity
D3W53_RS21165	COG2927	DNA polymerase III (CHI subunit)
D3W53_RS21170	COG0525	valine-tRNA ligase activity
D3W53_RS21175	COG4269	membrane
D3W53_RS21180	COG0456	acetyltransferase
D3W53_RS21185	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D3W53_RS21205	COG2731	YhcH YjgK YiaL family protein
D3W53_RS21210	COG1309	transcriptional regulator
D3W53_RS21215	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS21220	COG0251	oxidation-reduction process
D3W53_RS21245	COG0251	oxidation-reduction process
D3W53_RS21250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3W53_RS21260	COG1609	Transcriptional regulator
D3W53_RS21270	COG0366	Alpha amylase catalytic
D3W53_RS21275	COG1328	CTP reductase activity
D3W53_RS21280	COG0602	queuosine metabolic process
D3W53_RS21285	COG3783	Cytochrome b(562)
D3W53_RS21290	COG0312	modulator of DNA gyrase
D3W53_RS21300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3W53_RS21310	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS21315	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS21320	COG1129	ABC transporter
D3W53_RS21325	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS21330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3W53_RS21340	COG2105	PFAM AIG2 family protein
D3W53_RS21345	COG2911	Protein conserved in bacteria
D3W53_RS21350	COG0729	surface antigen
D3W53_RS21360	COG1253	flavin adenine dinucleotide binding
D3W53_RS21370	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D3W53_RS21375	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3W53_RS21380	COG0737	Belongs to the 5'-nucleotidase family
D3W53_RS21385	COG1733	regulation of RNA biosynthetic process
D3W53_RS21390	COG0702	epimerase
D3W53_RS21395	COG0697	spore germination
D3W53_RS21405	COG1113	amino acid transport
D3W53_RS21410	COG0545	Peptidyl-prolyl cis-trans isomerase
D3W53_RS21420	COG3061	Opacity-associated protein A
D3W53_RS21425	COG1309	transcriptional regulator
D3W53_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
D3W53_RS21440	COG1024	Enoyl-CoA hydratase
D3W53_RS21445	COG4670	ketone body catabolic process
D3W53_RS21455	COG2271	Major facilitator Superfamily
D3W53_RS21475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3W53_RS21515	COG3414	Phosphotransferase system galactitol-specific IIB component
D3W53_RS21520	COG3037	sugar-specific permease SgaT UlaA
D3W53_RS21535	COG1073	alpha beta
D3W53_RS21540	COG3650	response to hydrogen peroxide
D3W53_RS21555	COG1960	acyl-CoA dehydrogenase activity
D3W53_RS21560	COG0754	glutathionylspermidine amidase activity
D3W53_RS21565	COG5463	Belongs to the UPF0441 family
D3W53_RS21570	COG3766	membrane
D3W53_RS21580	COG1842	Phage shock protein A
D3W53_RS21585	COG3789	protein conserved in bacteria
D3W53_RS21595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3W53_RS21600	COG0557	exoribonuclease II activity
D3W53_RS21615	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D3W53_RS21620	COG0330	HflC and HflK could
D3W53_RS21625	COG0330	HflC and HflK could
D3W53_RS21630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3W53_RS21650	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3W53_RS21655	COG0802	atpase or kinase
D3W53_RS21660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3W53_RS21660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3W53_RS21665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3W53_RS21705	COG1511	domain protein
D3W53_RS21705	COG3264	Mechanosensitive ion channel
D3W53_RS21710	COG0531	amino acid
D3W53_RS21720	COG1053	succinate dehydrogenase
D3W53_RS21725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3W53_RS21740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3W53_RS21745	COG3040	lipid binding
D3W53_RS21750	COG2076	Multidrug Resistance protein
D3W53_RS21755	COG5510	response to toxic substance
D3W53_RS21760	COG5510	response to toxic substance
D3W53_RS21770	COG1509	lysine 2,3-aminomutase activity
D3W53_RS21795	COG0531	amino acid
D3W53_RS21800	COG3030	protein affecting phage T7 exclusion by the F plasmid
D3W53_RS21805	COG1027	Aspartate ammonia-lyase
D3W53_RS21810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3W53_RS21820	COG4232	protein-disulfide reductase activity
D3W53_RS21825	COG1309	transcriptional regulator
D3W53_RS21840	COG3710	Transcriptional regulator
D3W53_RS21845	COG0531	amino acid
D3W53_RS21850	COG1982	Orn Lys Arg decarboxylase major
D3W53_RS21855	COG3104	oligopeptide transport
D3W53_RS21860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3W53_RS21875	COG2388	GCN5-related N-acetyl-transferase
D3W53_RS21880	COG3592	Divergent 4Fe-4S mono-cluster
D3W53_RS21885	COG3290	protein histidine kinase activity
D3W53_RS21890	COG4565	transcriptional regulatory protein
D3W53_RS21900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3W53_RS21905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3W53_RS21905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3W53_RS21910	COG3647	Membrane
D3W53_RS21915	COG2211	Major facilitator Superfamily
D3W53_RS21920	COG1486	melibiose metabolic process
D3W53_RS21925	COG2169	Transcriptional regulator
D3W53_RS21930	COG1982	Orn Lys Arg decarboxylase major
D3W53_RS21935	COG2207	Transcriptional regulator
D3W53_RS21940	COG0531	amino acid
D3W53_RS21945	COG2194	sulfuric ester hydrolase activity
D3W53_RS21950	COG0745	RESPONSE REGULATOR receiver
D3W53_RS21955	COG0642	Histidine kinase
D3W53_RS21965	COG0477	Major facilitator Superfamily
D3W53_RS21975	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D3W53_RS21985	COG2824	Alkylphosphonate utilization operon protein PhnA
D3W53_RS21990	COG2764	glyoxalase bleomycin resistance protein dioxygenase
D3W53_RS21995	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D3W53_RS22000	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D3W53_RS22005	COG3639	organic phosphonate transmembrane transporter activity
D3W53_RS22010	COG2188	Transcriptional regulator
D3W53_RS22015	COG3624	Phosphonate C-P lyase system protein PhnG
D3W53_RS22020	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D3W53_RS22025	COG3626	phosphonate metabolism
D3W53_RS22030	COG3627	carbon phosphorus lyase activity
D3W53_RS22035	COG4107	phosphonate C-P lyase system protein PhnK
D3W53_RS22040	COG4778	phosphonate C-P lyase system protein PhnL
D3W53_RS22045	COG3454	Phosphonate metabolism
D3W53_RS22050	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D3W53_RS22055	COG0456	acetyltransferase
D3W53_RS22060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3W53_RS22070	COG0698	ribose 5-phosphate isomerase
D3W53_RS22080	COG1737	Transcriptional regulator
D3W53_RS22085	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS22090	COG1129	ABC transporter
D3W53_RS22095	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS22100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3W53_RS22105	COG1940	carbohydrate kinase activity
D3W53_RS22110	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D3W53_RS22120	COG1566	PFAM secretion protein HlyD family protein
D3W53_RS22140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D3W53_RS22145	COG1301	dicarboxylic acid transport
D3W53_RS22155	COG4235	cytochrome complex assembly
D3W53_RS22160	COG3088	subunit of a heme lyase
D3W53_RS22165	COG1138	Cytochrome C-type biogenesis protein
D3W53_RS22170	COG3301	Polysulphide reductase, NrfD
D3W53_RS22175	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS22180	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D3W53_RS22195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3W53_RS22200	COG3162	membrane
D3W53_RS22210	COG1357	PFAM Pentapeptide repeats (8 copies)
D3W53_RS22215	COG0025	NhaP-type Na H and K H
D3W53_RS22220	COG2252	PERMEase
D3W53_RS22225	COG0789	Transcriptional regulator
D3W53_RS22230	COG2207	Transcriptional regulator
D3W53_RS22235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D3W53_RS22250	COG0629	single-stranded DNA binding
D3W53_RS22255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3W53_RS22260	COG2315	Protein conserved in bacteria
D3W53_RS22265	COG0432	Pfam Uncharacterised protein family UPF0047
D3W53_RS22270	COG3700	Belongs to the class B bacterial acid phosphatase family
D3W53_RS22280	COG1448	Aminotransferase
D3W53_RS22285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3W53_RS22290	COG0305	Participates in initiation and elongation during chromosome replication
D3W53_RS22295	COG0604	alcohol dehydrogenase
D3W53_RS22305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3W53_RS22315	COG0735	belongs to the Fur family
D3W53_RS22320	COG3237	CsbD-like
D3W53_RS22325	COG0534	Mate efflux family protein
D3W53_RS22335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3W53_RS22370	COG3842	ATPase activity
D3W53_RS22375	COG2182	Extracellular solute-binding protein
D3W53_RS22380	COG1175	transmembrane transport
D3W53_RS22385	COG3833	ABC-type maltose transport systems, permease component
D3W53_RS22390	COG0477	Major facilitator Superfamily
D3W53_RS22390	COG2814	Major facilitator Superfamily
D3W53_RS22405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3W53_RS22435	COG0527	aspartate kinase activity
D3W53_RS22445	COG1187	pseudouridine synthase activity
D3W53_RS22455	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3W53_RS22460	COG0646	methionine synthase
D3W53_RS22460	COG1410	methionine synthase
D3W53_RS22465	COG1414	Transcriptional regulator
D3W53_RS22480	COG2224	Isocitrate lyase
D3W53_RS22485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3W53_RS22495	COG0456	acetyltransferase
D3W53_RS22535	COG0151	Belongs to the GarS family
D3W53_RS22540	COG2204	response regulator
D3W53_RS22545	COG4191	Histidine kinase
D3W53_RS22550	COG3678	ATP-independent chaperone mediated protein folding
D3W53_RS22565	COG3068	Protein conserved in bacteria
D3W53_RS22600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3W53_RS22605	COG2104	thiamine diphosphate biosynthetic process
D3W53_RS22615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3W53_RS22660	COG0250	Participates in transcription elongation, termination and antitermination
D3W53_RS22665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3W53_RS22705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D3W53_RS22705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D3W53_RS22710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3W53_RS22740	COG4206	TonB-dependent receptor
D3W53_RS22765	COG0583	DNA-binding transcription factor activity
D3W53_RS22780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3W53_RS22800	COG2194	sulfuric ester hydrolase activity
D3W53_RS22805	COG2207	Transcriptional regulator
D3W53_RS22810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS22815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3W53_RS22820	COG1882	Formate acetyltransferase
D3W53_RS22825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS22830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS22835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3W53_RS22835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS22835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS22840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3W53_RS22845	COG0371	Dehydrogenase
D3W53_RS22850	COG3738	Protein conserved in bacteria
D3W53_RS22855	COG0697	spore germination
D3W53_RS22865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D3W53_RS22870	COG0527	aspartate kinase activity
D3W53_RS22870	COG0460	homoserine dehydrogenase
D3W53_RS22875	COG0626	cystathionine gamma-synthase activity
D3W53_RS22885	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
D3W53_RS22895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3W53_RS22900	COG1609	Transcriptional regulator
D3W53_RS22905	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3W53_RS22920	COG1575	Belongs to the MenA family. Type 1 subfamily
D3W53_RS22935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3W53_RS22945	COG1494	fructose-1,6-bisphosphatase
D3W53_RS22950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3W53_RS22955	COG0589	response to stress
D3W53_RS22960	COG3691	Protein conserved in bacteria
D3W53_RS22965	COG3152	Membrane
D3W53_RS22985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3W53_RS23010	COG4974	Belongs to the 'phage' integrase family
D3W53_RS23015	COG3678	ATP-independent chaperone mediated protein folding
D3W53_RS23020	COG0745	RESPONSE REGULATOR receiver
D3W53_RS23025	COG2205	protein histidine kinase activity
D3W53_RS23030	COG2258	MOSC domain
D3W53_RS23040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3W53_RS23080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS23085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS23085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3W53_RS23090	COG1363	Peptidase, m42
D3W53_RS23095	COG3711	transcriptional antiterminator
D3W53_RS23095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3W53_RS23110	COG0243	molybdopterin cofactor binding
D3W53_RS23110	COG3383	formate dehydrogenase (NAD+) activity
D3W53_RS23115	COG3383	formate dehydrogenase (NAD+) activity
D3W53_RS23115	COG0243	molybdopterin cofactor binding
D3W53_RS23120	COG0437	4 iron, 4 sulfur cluster binding
D3W53_RS23125	COG2864	formate dehydrogenase
D3W53_RS23135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D3W53_RS23140	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D3W53_RS23145	COG0456	acetyltransferase
D3W53_RS23160	COG1011	Hydrolase
D3W53_RS23165	COG1349	DNA-binding transcription factor activity
D3W53_RS23170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS23175	COG2084	Dehydrogenase
D3W53_RS23180	COG3684	Belongs to the aldolase LacD family
D3W53_RS23185	COG2942	2-epimerase
D3W53_RS23190	COG2017	converts alpha-aldose to the beta-anomer
D3W53_RS23200	COG1501	Belongs to the glycosyl hydrolase 31 family
D3W53_RS23205	COG2211	Major facilitator Superfamily
D3W53_RS23210	COG2211	Major facilitator Superfamily
D3W53_RS23215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3W53_RS23220	COG2271	Major facilitator Superfamily
D3W53_RS23225	COG1082	Xylose isomerase domain protein TIM barrel
D3W53_RS23230	COG2188	Transcriptional regulator
D3W53_RS23235	COG1217	gtp-binding protein TYPA
D3W53_RS23245	COG0174	glutamine synthetase
D3W53_RS23250	COG3852	Histidine kinase
D3W53_RS23255	COG2204	response regulator
D3W53_RS23265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3W53_RS23270	COG3078	GTPase activator activity
D3W53_RS23280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3W53_RS23280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3W53_RS23290	COG0204	Acyl-transferase
D3W53_RS23295	COG5339	Protein conserved in bacteria
D3W53_RS23300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3W53_RS23305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3W53_RS23310	COG3084	Protein conserved in bacteria
D3W53_RS23315	COG0746	molybdenum cofactor guanylyltransferase activity
D3W53_RS23320	COG1763	Mo-molybdopterin cofactor biosynthetic process
D3W53_RS23350	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D3W53_RS23355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3W53_RS23360	COG1739	Uncharacterized protein family UPF0029
D3W53_RS23375	COG0183	Belongs to the thiolase family
D3W53_RS23380	COG0543	2 iron, 2 sulfur cluster binding
D3W53_RS23385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3W53_RS23390	COG0250	Participates in transcription elongation, termination and antitermination
D3W53_RS23395	COG0084	hydrolase, TatD family'
D3W53_RS23400	COG0805	protein transport
D3W53_RS23405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3W53_RS23410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3W53_RS23420	COG3165	ubiquinone biosynthetic process from chorismate
D3W53_RS23430	COG1322	Protein conserved in bacteria
D3W53_RS23435	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D3W53_RS23450	COG0583	DNA-binding transcription factor activity
D3W53_RS23455	COG0697	spore germination
D3W53_RS23460	COG0561	phosphatase activity
D3W53_RS23465	COG2267	carboxylic ester hydrolase activity
D3W53_RS23470	COG1280	lysine exporter protein (LysE YggA)
D3W53_RS23475	COG1280	lysine exporter protein (LysE YggA)
D3W53_RS23480	COG0514	ATP-dependent DNA helicase (RecQ)
D3W53_RS23485	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D3W53_RS23490	COG2050	protein possibly involved in aromatic compounds catabolism
D3W53_RS23495	COG2962	Rard protein
D3W53_RS23510	COG0598	Magnesium transport protein CorA
D3W53_RS23515	COG3698	Phosphodiester glycosidase
D3W53_RS23520	COG0210	DNA helicase
D3W53_RS23525	COG1011	Hydrolase
D3W53_RS23535	COG3159	Protein conserved in bacteria
D3W53_RS23545	COG5567	small periplasmic lipoprotein
D3W53_RS23555	COG3072	Adenylate cyclase
D3W53_RS23570	COG1587	Uroporphyrinogen-III synthase
D3W53_RS23575	COG2959	enzyme of heme biosynthesis
D3W53_RS23580	COG3071	HemY protein
D3W53_RS23585	COG3119	arylsulfatase activity
D3W53_RS23590	COG0641	radical SAM
D3W53_RS23615	COG1113	amino acid transport
D3W53_RS23635	COG2244	polysaccharide biosynthetic process
D3W53_RS23640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3W53_RS23645	COG0456	acetyltransferase
D3W53_RS23650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D3W53_RS23655	COG1088	dTDP-glucose 4,6-dehydratase activity
D3W53_RS23660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3W53_RS23665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D3W53_RS23670	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D3W53_RS23675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3W53_RS23685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3W53_RS23695	COG3118	belongs to the thioredoxin family
D3W53_RS23715	COG0210	DNA helicase
D3W53_RS23720	COG3692	DNA binding
D3W53_RS23725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3W53_RS23735	COG0583	DNA-binding transcription factor activity
D3W53_RS23740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3W53_RS23750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3W53_RS23755	COG3978	acetolactate synthase activity
D3W53_RS23780	COG0606	chelatase, subunit chli
D3W53_RS23785	COG3085	chromosome segregation
D3W53_RS23825	COG2186	Transcriptional regulator
D3W53_RS23830	COG0477	Major facilitator Superfamily
D3W53_RS23835	COG1609	Transcriptional regulator
D3W53_RS23840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3W53_RS23845	COG1879	ABC-type sugar transport system periplasmic component
D3W53_RS23850	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3W53_RS23855	COG1129	ABC transporter
D3W53_RS23885	COG1522	sequence-specific DNA binding
D3W53_RS23890	COG0716	FMN binding
D3W53_RS23905	COG3312	ion transport
D3W53_RS23955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3W53_RS23960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3W53_RS23965	COG0573	inorganic phosphate transmembrane transporter activity
D3W53_RS23970	COG0581	inorganic phosphate transmembrane transporter activity
D3W53_RS23975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3W53_RS23980	COG0704	Plays a role in the regulation of phosphate uptake
D3W53_RS23985	COG3711	transcriptional antiterminator
D3W53_RS23990	COG2190	(PTS) system
D3W53_RS23990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3W53_RS23990	COG1263	PTS System
D3W53_RS23995	COG2723	6-phospho-beta-galactosidase activity
D3W53_RS24005	COG2382	esterase
D3W53_RS24015	COG3196	Protein conserved in bacteria
D3W53_RS24025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3W53_RS24030	COG2252	PERMEase
D3W53_RS24035	COG0431	NADPH-dependent FMN reductase
D3W53_RS24040	COG2091	lysine biosynthetic process via aminoadipic acid
D3W53_RS24055	COG0814	amino acid
D3W53_RS24160	COG0616	signal peptide processing
D3W53_RS24380	COG1192	Involved in chromosome partitioning
D3W53_RS24465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3W53_RS24580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3W53_RS24605	COG5001	Diguanylate cyclase
D3W53_RS24640	COG0714	Associated with various cellular activities
D3W53_RS24650	COG0629	single-stranded DNA binding
D3W53_RS24700	COG0633	Ferredoxin
D3W53_RS24730	COG3385	transposase activity
D3W53_RS24845	COG1357	PFAM Pentapeptide repeats (8 copies)
D3W53_RS24910	COG3173	Aminoglycoside phosphotransferase
D3W53_RS25035	COG4974	Belongs to the 'phage' integrase family
D3W53_RS25280	COG2200	EAL domain
D3W53_RS25285	COG2199	diguanylate cyclase activity
D3W53_RS25305	COG1215	transferase activity, transferring glycosyl groups
D3W53_RS25315	COG3344	reverse transcriptase
D3W53_RS25345	COG0457	Tetratricopeptide repeat
D3W53_RS25345	COG3118	belongs to the thioredoxin family
D3W53_RS25370	COG2207	Transcriptional regulator
D3W53_RS25495	COG3039	Transposase
D3W53_RS25660	COG0697	spore germination
D3W53_RS25725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3W53_RS25845	COG4221	oxidoreductase activity
D3W53_RS25895	COG0697	spore germination
D3W53_RS25965	COG3173	Aminoglycoside phosphotransferase
D3W53_RS26000	COG0675	Transposase, IS605 OrfB family
D3W53_RS26115	COG2963	transposase activity