locus-tag	class	description
GK046_RS00100	COG5301	cellulose 1,4-beta-cellobiosidase activity
GK046_RS00115	COG3685	Protein conserved in bacteria
GK046_RS00120	COG3685	Protein conserved in bacteria
GK046_RS00125	COG3729	General stress protein
GK046_RS00140	COG0135	phosphoribosylanthranilate isomerase activity
GK046_RS00140	COG0134	indole-3-glycerol-phosphate synthase activity
GK046_RS00145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GK046_RS00145	COG0512	Glutamine amidotransferase of anthranilate synthase
GK046_RS00150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GK046_RS00160	COG0613	PHP domain protein
GK046_RS00165	COG0009	L-threonylcarbamoyladenylate synthase
GK046_RS00170	COG1187	pseudouridine synthase activity
GK046_RS00175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GK046_RS00180	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS00185	COG0616	signal peptide processing
GK046_RS00195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GK046_RS00200	COG0583	DNA-binding transcription factor activity
GK046_RS00220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GK046_RS00230	COG0671	phosphoesterase, PA-phosphatase related
GK046_RS00235	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GK046_RS00240	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GK046_RS00250	COG0023	Translation Initiation Factor
GK046_RS00260	COG1349	DNA-binding transcription factor activity
GK046_RS00270	COG5001	Diguanylate cyclase
GK046_RS00285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GK046_RS00285	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GK046_RS00290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GK046_RS00295	COG2852	Protein conserved in bacteria
GK046_RS00300	COG4172	Belongs to the ABC transporter superfamily
GK046_RS00305	COG4172	Belongs to the ABC transporter superfamily
GK046_RS00310	COG4171	peptide transport system, permease
GK046_RS00315	COG4168	peptide transport system, permease
GK046_RS00320	COG4166	transmembrane transport
GK046_RS00330	COG0531	amino acid
GK046_RS00340	COG0174	glutamine synthetase
GK046_RS00345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GK046_RS00350	COG1396	sequence-specific DNA binding
GK046_RS00350	COG1917	Cupin 2, conserved barrel domain protein
GK046_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS00360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GK046_RS00365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GK046_RS00370	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GK046_RS00375	COG1842	Phage shock protein A
GK046_RS00385	COG1983	PspC domain protein
GK046_RS00395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GK046_RS00400	COG0366	Alpha amylase catalytic
GK046_RS00405	COG1653	transport
GK046_RS00410	COG1175	transmembrane transport
GK046_RS00415	COG0395	ABC-type sugar transport system, permease component
GK046_RS00420	COG1063	alcohol dehydrogenase
GK046_RS00425	COG1082	Xylose isomerase domain protein TIM barrel
GK046_RS00430	COG0673	inositol 2-dehydrogenase activity
GK046_RS00440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GK046_RS00445	COG3842	ATPase activity
GK046_RS00455	COG1609	Transcriptional regulator
GK046_RS00460	COG3106	COG3106 Predicted ATPase
GK046_RS00470	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GK046_RS00475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GK046_RS00480	COG4948	Mandelate Racemase Muconate Lactonizing
GK046_RS00485	COG2866	Carboxypeptidase
GK046_RS00490	COG0702	epimerase
GK046_RS00495	COG1073	alpha beta
GK046_RS00500	COG1073	alpha beta
GK046_RS00505	COG0583	DNA-binding transcription factor activity
GK046_RS00510	COG4166	transmembrane transport
GK046_RS00515	COG0668	transmembrane transport
GK046_RS00520	COG3182	Iron-regulated membrane protein
GK046_RS00525	COG0589	response to stress
GK046_RS00530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GK046_RS00535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GK046_RS00540	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GK046_RS00545	COG1473	amidohydrolase
GK046_RS00550	COG1473	amidohydrolase
GK046_RS00555	COG0583	DNA-binding transcription factor activity
GK046_RS00560	COG2840	Smr protein MutS2
GK046_RS00565	COG3706	GGDEF domain
GK046_RS00575	COG0513	Belongs to the DEAD box helicase family
GK046_RS00585	COG0589	response to stress
GK046_RS00590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GK046_RS00595	COG0674	pyruvate-flavodoxin oxidoreductase activity
GK046_RS00595	COG1013	pyruvate-flavodoxin oxidoreductase activity
GK046_RS00595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GK046_RS00595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GK046_RS00600	COG3042	response to heat
GK046_RS00605	COG3187	Heat shock protein
GK046_RS00610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GK046_RS00615	COG2911	Protein conserved in bacteria
GK046_RS00625	COG3784	Protein of unknown function (DUF1318)
GK046_RS00630	COG2207	Transcriptional regulator
GK046_RS00635	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS00640	COG3733	amine oxidase
GK046_RS00645	COG2030	dehydratase
GK046_RS00645	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS00650	COG3396	Phenylacetate-CoA oxygenase
GK046_RS00655	COG3460	Phenylacetate-CoA oxygenase
GK046_RS00660	COG3396	Phenylacetate-CoA oxygenase
GK046_RS00665	COG2151	metal-sulfur cluster biosynthetic enzyme
GK046_RS00670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GK046_RS00675	COG1024	Enoyl-CoA hydratase
GK046_RS00680	COG1024	Enoyl-CoA hydratase
GK046_RS00685	COG1250	3-hydroxyacyl-CoA dehydrogenase
GK046_RS00690	COG2050	protein possibly involved in aromatic compounds catabolism
GK046_RS00695	COG0183	Belongs to the thiolase family
GK046_RS00700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GK046_RS00705	COG3327	negative regulation of DNA-templated transcription, initiation
GK046_RS00710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GK046_RS00715	COG0667	Aldo Keto reductase
GK046_RS00725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GK046_RS00730	COG4589	Belongs to the CDS family
GK046_RS00735	COG2267	carboxylic ester hydrolase activity
GK046_RS00740	COG0671	phosphoesterase, PA-phosphatase related
GK046_RS00740	COG2453	phosphatase
GK046_RS00750	COG1643	Atp-dependent helicase
GK046_RS00755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GK046_RS00760	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS00765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GK046_RS00770	COG3038	cytochrome b561
GK046_RS00785	COG0840	transmembrane signaling receptor activity
GK046_RS00790	COG0583	DNA-binding transcription factor activity
GK046_RS00795	COG5383	Protein conserved in bacteria
GK046_RS00805	COG2841	Protein conserved in bacteria
GK046_RS00810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GK046_RS00815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GK046_RS00820	COG1275	C4-dicarboxylate transporter malic acid transport protein
GK046_RS00825	COG0500	methyltransferase
GK046_RS00840	COG0675	Transposase, IS605 OrfB family
GK046_RS00845	COG3135	benzoate transporter
GK046_RS00850	COG1396	sequence-specific DNA binding
GK046_RS00855	COG0826	peptidase U32
GK046_RS00870	COG1598	PFAM Uncharacterised protein family UPF0150
GK046_RS00875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GK046_RS00880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GK046_RS00885	COG3842	ATPase activity
GK046_RS00890	COG1176	ABC-type spermidine putrescine transport system, permease component I
GK046_RS00895	COG1177	transmembrane transport
GK046_RS00925	COG3238	Protein conserved in bacteria
GK046_RS00930	COG1247	-acetyltransferase
GK046_RS00935	COG2130	NADP-dependent
GK046_RS00940	COG1802	Transcriptional regulator
GK046_RS00945	COG4772	TonB-dependent receptor
GK046_RS00950	COG3391	amine dehydrogenase activity
GK046_RS00955	COG1113	amino acid transport
GK046_RS00960	COG0625	glutathione transferase activity
GK046_RS00975	COG3209	COG3209 Rhs family protein
GK046_RS01015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GK046_RS01020	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GK046_RS01025	COG0384	phenazine biosynthesis protein PhzF
GK046_RS01030	COG2181	nitrate reductase activity
GK046_RS01035	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GK046_RS01040	COG1140	nitrate reductase beta subunit
GK046_RS01045	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GK046_RS01050	COG2223	nitrite transmembrane transporter activity
GK046_RS01055	COG4886	Leucine-rich repeat (LRR) protein
GK046_RS01060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GK046_RS01065	COG0697	spore germination
GK046_RS01075	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS01080	COG2864	formate dehydrogenase
GK046_RS01085	COG3093	addiction module antidote protein HigA
GK046_RS01090	COG1064	alcohol dehydrogenase
GK046_RS01110	COG1764	response to oxidative stress
GK046_RS01115	COG4608	Belongs to the ABC transporter superfamily
GK046_RS01120	COG0444	Belongs to the ABC transporter superfamily
GK046_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GK046_RS01130	COG0601	transmembrane transport
GK046_RS01135	COG0747	negative chemotaxis
GK046_RS01140	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
GK046_RS01145	COG2199	diguanylate cyclase activity
GK046_RS01145	COG2200	EAL domain
GK046_RS01145	COG2202	Pas domain
GK046_RS01155	COG1649	PFAM Uncharacterised BCR, COG1649
GK046_RS01160	COG0531	amino acid
GK046_RS01165	COG0076	glutamate decarboxylase activity
GK046_RS01170	COG0612	Peptidase, M16
GK046_RS01175	COG4771	TonB-dependent receptor
GK046_RS01180	COG4178	(ABC) transporter
GK046_RS01190	COG0641	radical SAM
GK046_RS01195	COG3119	arylsulfatase activity
GK046_RS01200	COG2207	Transcriptional regulator
GK046_RS01210	COG0243	molybdopterin cofactor binding
GK046_RS01215	COG3539	Fimbrial protein
GK046_RS01220	COG3539	Fimbrial protein
GK046_RS01225	COG3539	Fimbrial protein
GK046_RS01230	COG3188	usher protein
GK046_RS01240	COG3539	Fimbrial protein
GK046_RS01250	COG3550	peptidyl-serine autophosphorylation
GK046_RS01255	COG1396	sequence-specific DNA binding
GK046_RS01260	COG3210	domain, Protein
GK046_RS01260	COG2911	Protein conserved in bacteria
GK046_RS01310	COG3781	membrane
GK046_RS01320	COG2199	diguanylate cyclase activity
GK046_RS01330	COG2066	Belongs to the glutaminase family
GK046_RS01335	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS01340	COG0583	DNA-binding transcription factor activity
GK046_RS01365	COG1846	Transcriptional regulator
GK046_RS01370	COG4977	sequence-specific DNA binding
GK046_RS01380	COG2723	6-phospho-beta-galactosidase activity
GK046_RS01390	COG1447	Phosphotransferase system cellobiose-specific component IIA
GK046_RS01395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GK046_RS01405	COG2188	Transcriptional regulator
GK046_RS01410	COG0697	spore germination
GK046_RS01415	COG2814	Major facilitator Superfamily
GK046_RS01425	COG3706	GGDEF domain
GK046_RS01430	COG3111	PFAM Bacterial OB fold (BOF) protein
GK046_RS01435	COG1546	Belongs to the CinA family
GK046_RS01440	COG0339	signal peptide processing
GK046_RS01445	COG4221	oxidoreductase activity
GK046_RS01450	COG1802	Transcriptional regulator
GK046_RS01460	COG0246	Mannitol dehydrogenase
GK046_RS01465	COG0477	Major facilitator Superfamily
GK046_RS01470	COG1063	alcohol dehydrogenase
GK046_RS01475	COG4948	Mandelate Racemase Muconate Lactonizing
GK046_RS01490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GK046_RS01505	COG0243	molybdopterin cofactor binding
GK046_RS01510	COG0243	molybdopterin cofactor binding
GK046_RS01515	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS01520	COG3302	dmso reductase anchor subunit
GK046_RS01525	COG3381	protein complex oligomerization
GK046_RS01535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GK046_RS01540	COG1940	carbohydrate kinase activity
GK046_RS01545	COG0583	DNA-binding transcription factor activity
GK046_RS01550	COG2814	Major facilitator Superfamily
GK046_RS01565	COG3591	Belongs to the peptidase S1B family
GK046_RS01585	COG0628	permease
GK046_RS01590	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GK046_RS01595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GK046_RS01605	COG0531	amino acid
GK046_RS01615	COG3136	membrane protein required for alginate biosynthesis
GK046_RS01620	COG0745	RESPONSE REGULATOR receiver
GK046_RS01625	COG2205	protein histidine kinase activity
GK046_RS01635	COG0114	fumarate hydratase activity
GK046_RS01640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GK046_RS01640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GK046_RS01645	COG1482	cell wall glycoprotein biosynthetic process
GK046_RS01650	COG5339	Protein conserved in bacteria
GK046_RS01665	COG3250	beta-galactosidase activity
GK046_RS01670	COG1309	transcriptional regulator
GK046_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS01680	COG1609	Transcriptional regulator
GK046_RS01685	COG1263	PTS System
GK046_RS01685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS01690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GK046_RS01700	COG0673	inositol 2-dehydrogenase activity
GK046_RS01740	COG4659	FMN binding
GK046_RS01750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GK046_RS01755	COG3104	oligopeptide transport
GK046_RS01760	COG0625	glutathione transferase activity
GK046_RS01765	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GK046_RS01780	COG3895	Periplasmic Protein
GK046_RS01790	COG3133	Outer membrane lipoprotein
GK046_RS01805	COG1566	PFAM secretion protein HlyD family protein
GK046_RS01810	COG1289	transmembrane transporter activity
GK046_RS01815	COG2032	superoxide dismutase activity
GK046_RS01820	COG4989	oxidoreductase activity
GK046_RS01825	COG3313	Fe-S protein
GK046_RS01830	COG1309	transcriptional regulator
GK046_RS01835	COG1902	pentaerythritol trinitrate reductase activity
GK046_RS01840	COG0346	lactoylglutathione lyase activity
GK046_RS01850	COG1201	RNA secondary structure unwinding
GK046_RS01855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GK046_RS01860	COG0791	NLP P60 protein
GK046_RS01865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GK046_RS01870	COG2814	Major facilitator Superfamily
GK046_RS01885	COG0583	DNA-binding transcription factor activity
GK046_RS01890	COG2814	Major facilitator Superfamily
GK046_RS01895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GK046_RS01900	COG0307	riboflavin synthase, alpha
GK046_RS01910	COG3468	outer membrane autotransporter barrel domain protein
GK046_RS01930	COG4529	Protein conserved in bacteria
GK046_RS01940	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GK046_RS01945	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS01955	COG2414	aldehyde ferredoxin oxidoreductase
GK046_RS01960	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS01970	COG0469	pyruvate kinase activity
GK046_RS01975	COG4238	major outer membrane lipoprotein
GK046_RS01980	COG1376	ErfK ybiS ycfS ynhG family protein
GK046_RS01995	COG0719	Fe-S assembly protein
GK046_RS02000	COG0396	ATPase activity
GK046_RS02005	COG0719	Fe-S assembly protein
GK046_RS02010	COG0316	Belongs to the HesB IscA family
GK046_RS02020	COG2050	protein possibly involved in aromatic compounds catabolism
GK046_RS02025	COG0247	lactate metabolic process
GK046_RS02025	COG0277	FAD linked oxidase domain protein
GK046_RS02030	COG0628	permease
GK046_RS02045	COG0738	Major facilitator superfamily
GK046_RS02050	COG2271	Major facilitator Superfamily
GK046_RS02065	COG4670	ketone body catabolic process
GK046_RS02070	COG1960	acyl-CoA dehydrogenase activity
GK046_RS02075	COG2207	Transcriptional regulator
GK046_RS02075	COG1917	Cupin 2, conserved barrel domain protein
GK046_RS02080	COG2086	electron transfer activity
GK046_RS02085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GK046_RS02090	COG0644	oxidoreductase
GK046_RS02095	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GK046_RS02100	COG0318	PFAM AMP-dependent synthetase and ligase
GK046_RS02105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GK046_RS02105	COG0574	Belongs to the PEP-utilizing enzyme family
GK046_RS02115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GK046_RS02120	COG4256	Hemin uptake protein
GK046_RS02130	COG2200	EAL domain
GK046_RS02135	COG0791	NLP P60 protein
GK046_RS02145	COG0386	Belongs to the glutathione peroxidase family
GK046_RS02205	COG3137	Salt-induced outer membrane protein
GK046_RS02210	COG1105	Belongs to the carbohydrate kinase PfkB family
GK046_RS02220	COG3001	Fructosamine kinase
GK046_RS02230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GK046_RS02235	COG1988	membrane-bound metal-dependent
GK046_RS02240	COG1823	symporter activity
GK046_RS02260	COG0753	catalase activity
GK046_RS02270	COG1486	melibiose metabolic process
GK046_RS02275	COG1917	Cupin 2, conserved barrel domain protein
GK046_RS02275	COG2169	Transcriptional regulator
GK046_RS02280	COG1447	Phosphotransferase system cellobiose-specific component IIA
GK046_RS02285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GK046_RS02290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GK046_RS02295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GK046_RS02305	COG0322	excinuclease ABC activity
GK046_RS02315	COG3678	ATP-independent chaperone mediated protein folding
GK046_RS02345	COG0708	Exodeoxyribonuclease III
GK046_RS02350	COG0398	Pfam SNARE associated Golgi protein
GK046_RS02360	COG0398	Pfam SNARE associated Golgi protein
GK046_RS02365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GK046_RS02370	COG4134	Bacterial extracellular solute-binding protein
GK046_RS02375	COG4135	transport system, permease component
GK046_RS02380	COG4136	ATPase activity
GK046_RS02385	COG2897	thiosulfate sulfurtransferase activity
GK046_RS02390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GK046_RS02395	COG0494	nUDIX hydrolase
GK046_RS02405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GK046_RS02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GK046_RS02425	COG0778	Nitroreductase
GK046_RS02430	COG0616	signal peptide processing
GK046_RS02435	COG0252	asparaginase activity
GK046_RS02440	COG1335	isochorismatase
GK046_RS02445	COG3139	Protein of unknown function (DUF1315)
GK046_RS02455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GK046_RS02460	COG0676	glucose-6-phosphate 1-epimerase activity
GK046_RS02465	COG0656	L-ascorbic acid biosynthetic process
GK046_RS02470	COG3713	MltA-interacting MipA family protein
GK046_RS02475	COG2766	serine protein kinase
GK046_RS02485	COG2199	diguanylate cyclase activity
GK046_RS02490	COG2199	diguanylate cyclase activity
GK046_RS02495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GK046_RS02510	COG2207	Transcriptional regulator
GK046_RS02515	COG2807	transmembrane transport
GK046_RS02520	COG3189	MarR family transcriptional regulator
GK046_RS02525	COG3042	response to heat
GK046_RS02530	COG2203	Gaf domain
GK046_RS02530	COG2199	diguanylate cyclase activity
GK046_RS02545	COG2261	transglycosylase associated protein
GK046_RS02550	COG0675	Transposase, IS605 OrfB family
GK046_RS02565	COG3615	Tellurite resistance protein tehB
GK046_RS02575	COG0583	DNA-binding transcription factor activity
GK046_RS02580	COG0473	3-isopropylmalate dehydrogenase activity
GK046_RS02585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GK046_RS02590	COG4638	Rieske (2fe-2S)
GK046_RS02595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GK046_RS02600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GK046_RS02605	COG0318	PFAM AMP-dependent synthetase and ligase
GK046_RS02610	COG3065	identical protein binding
GK046_RS02615	COG1214	PFAM Peptidase M22, glycoprotease
GK046_RS02620	COG1199	ATP-dependent helicase activity
GK046_RS02625	COG0251	oxidation-reduction process
GK046_RS02640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GK046_RS02650	COG1760	l-serine dehydratase
GK046_RS02655	COG2200	EAL domain
GK046_RS02660	COG1253	flavin adenine dinucleotide binding
GK046_RS02665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS02665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS02670	COG3715	PTS system
GK046_RS02675	COG3716	PTS system mannose fructose sorbose family IID component
GK046_RS02690	COG2226	methyltransferase
GK046_RS02720	COG1414	Transcriptional regulator
GK046_RS02725	COG2814	Major facilitator Superfamily
GK046_RS02735	COG0793	Belongs to the peptidase S41A family
GK046_RS02745	COG1956	GAF domain-containing protein
GK046_RS02750	COG2995	paraquat-inducible protein a
GK046_RS02755	COG3008	intermembrane lipid transfer
GK046_RS02775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GK046_RS02785	COG1276	copper resistance
GK046_RS02790	COG2372	response to copper ion
GK046_RS02800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GK046_RS02805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GK046_RS02810	COG1770	oligopeptidase
GK046_RS02815	COG2979	Protein of unknown function (DUF533)
GK046_RS02825	COG3141	response to X-ray
GK046_RS02835	COG0800	Aldolase
GK046_RS02840	COG0129	dihydroxy-acid dehydratase activity
GK046_RS02845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GK046_RS02850	COG1737	Transcriptional regulator
GK046_RS02855	COG0469	pyruvate kinase activity
GK046_RS02885	COG1175	transmembrane transport
GK046_RS02890	COG2182	Extracellular solute-binding protein
GK046_RS02900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GK046_RS02910	COG3842	ATPase activity
GK046_RS02930	COG1560	Kdo2-lipid A biosynthetic process
GK046_RS02935	COG0739	heme binding
GK046_RS02940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GK046_RS02950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GK046_RS02980	COG0217	transcriptional regulatory protein
GK046_RS02985	COG0494	nUDIX hydrolase
GK046_RS02995	COG1335	isochorismatase
GK046_RS03000	COG1801	Protein of unknown function DUF72
GK046_RS03005	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GK046_RS03020	COG0243	molybdopterin cofactor binding
GK046_RS03025	COG3005	denitrification pathway
GK046_RS03035	COG3102	Protein conserved in bacteria
GK046_RS03045	COG3755	Protein conserved in bacteria
GK046_RS03055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GK046_RS03060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GK046_RS03065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GK046_RS03070	COG0745	RESPONSE REGULATOR receiver
GK046_RS03075	COG2201	protein-glutamate methylesterase activity
GK046_RS03080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GK046_RS03085	COG0840	transmembrane signaling receptor activity
GK046_RS03090	COG0840	transmembrane signaling receptor activity
GK046_RS03095	COG0835	chemotaxis
GK046_RS03100	COG2198	Histidine kinase
GK046_RS03100	COG0643	Histidine kinase
GK046_RS03105	COG1360	Flagellar Motor Protein
GK046_RS03110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GK046_RS03125	COG0589	response to stress
GK046_RS03135	COG1877	trehalose-phosphatase activity
GK046_RS03140	COG1172	Belongs to the binding-protein-dependent transport system permease family
GK046_RS03145	COG1129	ABC transporter
GK046_RS03150	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS03155	COG1528	Iron-storage protein
GK046_RS03175	COG1528	Iron-storage protein
GK046_RS03185	COG0814	amino acid
GK046_RS03190	COG3012	SEC-C Motif Domain Protein
GK046_RS03190	COG3318	Belongs to the UPF0149 family
GK046_RS03220	COG2197	response regulator
GK046_RS03235	COG2197	response regulator
GK046_RS03240	COG1126	abc transporter atp-binding protein
GK046_RS03245	COG0765	amino acid transport
GK046_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS03265	COG1191	sigma factor activity
GK046_RS03275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GK046_RS03280	COG1516	flagellar protein fliS
GK046_RS03290	COG0366	Alpha amylase catalytic
GK046_RS03300	COG2391	methyltransferase activity
GK046_RS03305	COG0425	Belongs to the sulfur carrier protein TusA family
GK046_RS03310	COG2135	peptidase activity
GK046_RS03320	COG1766	The M ring may be actively involved in energy transduction
GK046_RS03325	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GK046_RS03330	COG1317	bacterial-type flagellum organization
GK046_RS03335	COG1157	protein secretion by the type III secretion system
GK046_RS03340	COG2882	bacterial-type flagellum organization
GK046_RS03345	COG3144	bacterial-type flagellum assembly
GK046_RS03350	COG1580	Controls the rotational direction of flagella during chemotaxis
GK046_RS03355	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GK046_RS03360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GK046_RS03365	COG3190	flagellar
GK046_RS03370	COG1338	Plays a role in the flagellum-specific transport system
GK046_RS03375	COG1987	bacterial-type flagellum assembly
GK046_RS03380	COG1684	flagellar biosynthetic protein fliR
GK046_RS03385	COG2197	response regulator
GK046_RS03410	COG5475	Uncharacterized small protein (DUF2158)
GK046_RS03415	COG2354	Protein conserved in bacteria
GK046_RS03420	COG0697	spore germination
GK046_RS03425	COG3727	T/G mismatch-specific endonuclease activity
GK046_RS03430	COG0270	DNA (cytosine-5-)-methyltransferase activity
GK046_RS03435	COG1418	mRNA catabolic process
GK046_RS03445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GK046_RS03455	COG2205	protein histidine kinase activity
GK046_RS03460	COG0745	RESPONSE REGULATOR receiver
GK046_RS03465	COG2351	hydroxyisourate hydrolase activity
GK046_RS03480	COG3443	Belongs to the bacterial solute-binding protein 9 family
GK046_RS03485	COG3038	cytochrome b561
GK046_RS03530	COG5301	cellulose 1,4-beta-cellobiosidase activity
GK046_RS03545	COG2032	superoxide dismutase activity
GK046_RS03640	COG4220	transposase activity
GK046_RS03680	COG3772	lysozyme
GK046_RS03700	COG3436	PFAM IS66 Orf2 family protein
GK046_RS03705	COG4372	Transposase
GK046_RS03745	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GK046_RS03750	COG1403	HNH endonuclease
GK046_RS03780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GK046_RS03795	COG1846	Transcriptional regulator
GK046_RS03810	COG1396	sequence-specific DNA binding
GK046_RS03840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GK046_RS03890	COG0477	Major facilitator Superfamily
GK046_RS03895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GK046_RS03900	COG0217	transcriptional regulatory protein
GK046_RS03910	COG0534	Mate efflux family protein
GK046_RS03920	COG0583	DNA-binding transcription factor activity
GK046_RS03925	COG0583	DNA-binding transcription factor activity
GK046_RS03935	COG1376	ErfK ybiS ycfS ynhG family protein
GK046_RS03950	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GK046_RS03955	COG4917	ethanolamine utilization protein
GK046_RS03965	COG1289	transmembrane transporter activity
GK046_RS03975	COG1686	Belongs to the peptidase S11 family
GK046_RS03980	COG2925	Exonuclease
GK046_RS03985	COG0425	Belongs to the sulfur carrier protein TusA family
GK046_RS03990	COG2391	methyltransferase activity
GK046_RS03995	COG0531	amino acid
GK046_RS04005	COG0583	DNA-binding transcription factor activity
GK046_RS04010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GK046_RS04025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GK046_RS04035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GK046_RS04035	COG0131	Imidazoleglycerol-phosphate dehydratase
GK046_RS04040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GK046_RS04085	COG0438	transferase activity, transferring glycosyl groups
GK046_RS04100	COG0297	glycogen (starch) synthase activity
GK046_RS04115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GK046_RS04120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GK046_RS04130	COG0438	transferase activity, transferring glycosyl groups
GK046_RS04135	COG2327	Polysaccharide pyruvyl transferase
GK046_RS04140	COG2244	polysaccharide biosynthetic process
GK046_RS04145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GK046_RS04150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GK046_RS04155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GK046_RS04155	COG0662	Cupin 2, conserved barrel domain protein
GK046_RS04160	COG0297	glycogen (starch) synthase activity
GK046_RS04165	COG1051	belongs to the nudix hydrolase family
GK046_RS04170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GK046_RS04175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GK046_RS04180	COG0110	maltose O-acetyltransferase activity
GK046_RS04185	COG1216	Glycosyl transferase, family 2
GK046_RS04195	COG0438	transferase activity, transferring glycosyl groups
GK046_RS04200	COG1045	serine acetyltransferase
GK046_RS04205	COG0463	Glycosyl transferase, family 2
GK046_RS04210	COG3206	protein involved in exopolysaccharide biosynthesis
GK046_RS04210	COG0489	protein tyrosine kinase activity
GK046_RS04215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GK046_RS04220	COG1596	polysaccharide export
GK046_RS04225	COG1253	flavin adenine dinucleotide binding
GK046_RS04230	COG2982	Protein involved in outer membrane biogenesis
GK046_RS04240	COG0572	uridine kinase
GK046_RS04245	COG3447	MASE1 domain protein
GK046_RS04245	COG5001	Diguanylate cyclase
GK046_RS04245	COG5002	protein histidine kinase activity
GK046_RS04250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GK046_RS04255	COG0443	Heat shock 70 kDa protein
GK046_RS04260	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
GK046_RS04265	COG0631	protein serine/threonine phosphatase activity
GK046_RS04270	COG4245	von Willebrand factor, type A
GK046_RS04310	COG5301	cellulose 1,4-beta-cellobiosidase activity
GK046_RS04345	COG1196	nuclear chromosome segregation
GK046_RS04395	COG1030	water channel activity
GK046_RS04415	COG4220	transposase activity
GK046_RS04425	COG3646	Phage regulatory protein
GK046_RS04435	COG3772	lysozyme
GK046_RS04625	COG3561	AntA/AntB antirepressor
GK046_RS04635	COG0582	viral genome integration into host DNA
GK046_RS04660	COG2205	protein histidine kinase activity
GK046_RS04665	COG0745	RESPONSE REGULATOR receiver
GK046_RS04675	COG3609	addiction module antidote protein, CC2985 family
GK046_RS04685	COG0826	peptidase U32
GK046_RS04705	COG1063	alcohol dehydrogenase
GK046_RS04710	COG3775	system Galactitol-specific IIC component
GK046_RS04715	COG3414	Phosphotransferase system galactitol-specific IIB component
GK046_RS04720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS04735	COG1830	Aldolase
GK046_RS04740	COG2211	Major facilitator Superfamily
GK046_RS04745	COG1397	ADP-ribosylglycohydrolase
GK046_RS04750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GK046_RS04755	COG2188	Transcriptional regulator
GK046_RS04760	COG3757	hydrolase, family 25
GK046_RS04765	COG0351	phosphomethylpyrimidine kinase
GK046_RS04785	COG5455	response to cobalt ion
GK046_RS04790	COG3539	Fimbrial protein
GK046_RS04795	COG3188	usher protein
GK046_RS04800	COG3121	Chaperone
GK046_RS04805	COG3539	Fimbrial protein
GK046_RS04815	COG0489	protein tyrosine kinase activity
GK046_RS04825	COG3831	ATPase activity
GK046_RS04830	COG3831	ATPase activity
GK046_RS04840	COG0714	Associated with various cellular activities
GK046_RS04845	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GK046_RS04850	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GK046_RS04855	COG4715	Zinc finger, swim domain protein
GK046_RS04860	COG4808	Protein conserved in bacteria
GK046_RS04865	COG4807	Protein conserved in bacteria
GK046_RS04870	COG3279	Response regulator of the LytR AlgR family
GK046_RS04875	COG3275	phosphorelay sensor kinase activity
GK046_RS04880	COG0789	Transcriptional regulator
GK046_RS04890	COG1174	glycine betaine transport
GK046_RS04895	COG1125	glycine betaine transport
GK046_RS04900	COG1174	glycine betaine transport
GK046_RS04905	COG1732	Glycine betaine
GK046_RS04910	COG1472	Belongs to the glycosyl hydrolase 3 family
GK046_RS04915	COG0277	FAD linked oxidase domain protein
GK046_RS04920	COG1686	Belongs to the peptidase S11 family
GK046_RS04930	COG0586	Pfam SNARE associated Golgi protein
GK046_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS04950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GK046_RS04960	COG1346	cytolysis
GK046_RS04970	COG2949	membrane
GK046_RS04980	COG0493	'glutamate synthase
GK046_RS04985	COG0167	dihydroorotate dehydrogenase activity
GK046_RS04985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GK046_RS04990	COG4211	Belongs to the binding-protein-dependent transport system permease family
GK046_RS04995	COG1129	ABC transporter
GK046_RS05000	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS05005	COG1609	Transcriptional regulator
GK046_RS05010	COG2311	Membrane
GK046_RS05025	COG4771	TonB-dependent receptor
GK046_RS05030	COG0833	amino acid
GK046_RS05035	COG0583	DNA-binding transcription factor activity
GK046_RS05040	COG2855	membrane
GK046_RS05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GK046_RS05050	COG1522	sequence-specific DNA binding
GK046_RS05055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GK046_RS05065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GK046_RS05070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GK046_RS05075	COG2313	pseudouridylate synthase activity
GK046_RS05080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GK046_RS05085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS05085	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GK046_RS05085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS05090	COG1105	Belongs to the carbohydrate kinase PfkB family
GK046_RS05095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS05095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS05100	COG2814	Major facilitator Superfamily
GK046_RS05115	COG0246	Mannitol dehydrogenase
GK046_RS05120	COG0523	cobalamin synthesis protein
GK046_RS05125	COG0671	phosphoesterase, PA-phosphatase related
GK046_RS05130	COG0791	NLP P60 protein
GK046_RS05135	COG2200	EAL domain
GK046_RS05140	COG4166	transmembrane transport
GK046_RS05145	COG4174	ABC transporter (Permease)
GK046_RS05150	COG4239	(ABC) transporter, permease
GK046_RS05155	COG4172	Belongs to the ABC transporter superfamily
GK046_RS05165	COG2814	Major facilitator Superfamily
GK046_RS05170	COG1187	pseudouridine synthase activity
GK046_RS05175	COG1061	Type III restriction enzyme res subunit
GK046_RS05195	COG3083	sulfuric ester hydrolase activity
GK046_RS05210	COG2197	response regulator
GK046_RS05215	COG4235	cytochrome complex assembly
GK046_RS05215	COG3088	subunit of a heme lyase
GK046_RS05220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GK046_RS05225	COG1138	Cytochrome C-type biogenesis protein
GK046_RS05235	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GK046_RS05240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GK046_RS05245	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GK046_RS05255	COG3005	denitrification pathway
GK046_RS05260	COG3043	anaerobic respiration
GK046_RS05265	COG0348	domain, Protein
GK046_RS05270	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS05280	COG3062	negative regulation of establishment of protein localization
GK046_RS05285	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS05285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS05305	COG4615	Cyclic peptide transporter
GK046_RS05310	COG3145	DNA-N1-methyladenine dioxygenase activity
GK046_RS05315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GK046_RS05315	COG2169	Transcriptional regulator
GK046_RS05320	COG1477	protein flavinylation
GK046_RS05330	COG2198	Histidine kinase
GK046_RS05330	COG0642	Histidine kinase
GK046_RS05335	COG2197	response regulator
GK046_RS05340	COG2205	protein histidine kinase activity
GK046_RS05340	COG0784	Response regulator, receiver
GK046_RS05345	COG3852	Histidine kinase
GK046_RS05350	COG2204	response regulator
GK046_RS05355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GK046_RS05360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GK046_RS05365	COG2031	fatty acid transporter
GK046_RS05370	COG0183	Belongs to the thiolase family
GK046_RS05375	COG4676	Protein conserved in bacteria
GK046_RS05380	COG5445	Predicted secreted protein (DUF2300)
GK046_RS05385	COG2373	Large extracellular alpha-helical protein
GK046_RS05390	COG3234	Protein of unknown function (DUF1175)
GK046_RS05395	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
GK046_RS05400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GK046_RS05410	COG3468	outer membrane autotransporter barrel domain protein
GK046_RS05415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GK046_RS05420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GK046_RS05425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GK046_RS05430	COG3642	lipopolysaccharide core region biosynthetic process
GK046_RS05440	COG0584	glycerophosphoryl diester phosphodiesterase
GK046_RS05445	COG2271	Major facilitator Superfamily
GK046_RS05450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GK046_RS05460	COG0247	lactate metabolic process
GK046_RS05465	COG5464	transposase or invertase
GK046_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
GK046_RS05545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GK046_RS05560	COG1169	isochorismate synthase
GK046_RS05565	COG4575	ribosome binding
GK046_RS05570	COG2153	protein acetylation
GK046_RS05600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GK046_RS05605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GK046_RS05615	COG0839	Belongs to the complex I subunit 6 family
GK046_RS05630	COG1034	ATP synthesis coupled electron transport
GK046_RS05635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GK046_RS05640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GK046_RS05660	COG0583	DNA-binding transcription factor activity
GK046_RS05665	COG0436	Aminotransferase
GK046_RS05675	COG0490	domain, Protein
GK046_RS05675	COG0471	metal ion transport
GK046_RS05680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GK046_RS05695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GK046_RS05700	COG0857	belongs to the CobB CobQ family
GK046_RS05700	COG0280	phosphate acetyltransferase
GK046_RS05705	COG1288	antiporter activity
GK046_RS05710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GK046_RS05715	COG0622	Phosphoesterase
GK046_RS05720	COG0625	glutathione transferase activity
GK046_RS05725	COG0625	glutathione transferase activity
GK046_RS05730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GK046_RS05735	COG1090	epimerase
GK046_RS05740	COG5464	transposase or invertase
GK046_RS05745	COG4598	ABC transporter
GK046_RS05750	COG4160	amino acid transport
GK046_RS05755	COG4215	(ABC) transporter
GK046_RS05760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS05770	COG0163	prenyltransferase activity
GK046_RS05775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GK046_RS05780	COG1286	toxin biosynthetic process
GK046_RS05785	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GK046_RS05790	COG0285	dihydrofolate synthase activity
GK046_RS05800	COG0586	Pfam SNARE associated Golgi protein
GK046_RS05810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GK046_RS05825	COG2814	Major facilitator Superfamily
GK046_RS05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GK046_RS05845	COG3101	peptidyl-lysine hydroxylation
GK046_RS05850	COG0730	response to heat
GK046_RS05875	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS05885	COG3539	Fimbrial protein
GK046_RS05890	COG3539	Fimbrial protein
GK046_RS05895	COG3539	Fimbrial protein
GK046_RS05900	COG3121	Chaperone
GK046_RS05905	COG3188	usher protein
GK046_RS05910	COG3539	Fimbrial protein
GK046_RS05915	COG2062	phosphohistidine phosphatase, SixA
GK046_RS05930	COG3691	Protein conserved in bacteria
GK046_RS05935	COG2067	long-chain fatty acid transport protein
GK046_RS05945	COG2853	Lipoprotein
GK046_RS05950	COG2116	formate transmembrane transporter activity
GK046_RS05990	COG0477	Major facilitator Superfamily
GK046_RS05995	COG1566	PFAM secretion protein HlyD family protein
GK046_RS06000	COG2197	response regulator
GK046_RS06005	COG0784	Response regulator, receiver
GK046_RS06005	COG2198	Histidine kinase
GK046_RS06005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS06005	COG2205	protein histidine kinase activity
GK046_RS06010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GK046_RS06015	COG0679	Auxin Efflux Carrier
GK046_RS06020	COG0028	Belongs to the TPP enzyme family
GK046_RS06045	COG1560	Kdo2-lipid A biosynthetic process
GK046_RS06055	COG0436	Aminotransferase
GK046_RS06060	COG3275	phosphorelay sensor kinase activity
GK046_RS06065	COG3279	Response regulator of the LytR AlgR family
GK046_RS06070	COG2207	Transcriptional regulator
GK046_RS06080	COG1363	Peptidase, m42
GK046_RS06085	COG0006	proline dipeptidase activity
GK046_RS06090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS06095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS06120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GK046_RS06125	COG3385	transposase activity
GK046_RS06130	COG2199	diguanylate cyclase activity
GK046_RS06130	COG2200	EAL domain
GK046_RS06145	COG3415	Transposase
GK046_RS06150	COG3415	Transposase
GK046_RS06185	COG0583	DNA-binding transcription factor activity
GK046_RS06190	COG0385	Bile acid
GK046_RS06195	COG3530	Putative quorum-sensing-regulated virulence factor
GK046_RS06215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GK046_RS06220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS06225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GK046_RS06230	COG2190	(PTS) system
GK046_RS06245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GK046_RS06250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GK046_RS06255	COG4208	sulfate ABC transporter
GK046_RS06260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GK046_RS06265	COG4150	thiosulfate binding
GK046_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS06285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS06285	COG1263	PTS System
GK046_RS06290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GK046_RS06295	COG2837	iron assimilation
GK046_RS06315	COG0860	N-Acetylmuramoyl-L-alanine amidase
GK046_RS06325	COG2207	Transcriptional regulator
GK046_RS06330	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GK046_RS06335	COG4816	utilization protein
GK046_RS06345	COG4303	Ethanolamine ammonia lyase large subunit
GK046_RS06350	COG4819	ethanolamine utilization protein
GK046_RS06355	COG3192	ethanolamine utilization protein
GK046_RS06360	COG1454	alcohol dehydrogenase
GK046_RS06365	COG4820	ethanolamine utilization protein (EutJ)
GK046_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS06375	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GK046_RS06380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GK046_RS06385	COG0280	phosphate acetyltransferase
GK046_RS06390	COG4812	Cobalamin adenosyltransferase
GK046_RS06395	COG4766	ethanolamine catabolic process
GK046_RS06400	COG4917	ethanolamine utilization protein
GK046_RS06405	COG4810	utilization protein
GK046_RS06410	COG0280	phosphate acetyltransferase
GK046_RS06410	COG0281	malic enzyme
GK046_RS06415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GK046_RS06420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GK046_RS06425	COG5342	invasion associated locus B
GK046_RS06435	COG0493	'glutamate synthase
GK046_RS06435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS06440	COG3850	Histidine kinase
GK046_RS06445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GK046_RS06455	COG1393	Belongs to the ArsC family
GK046_RS06470	COG0400	carboxylic ester hydrolase activity
GK046_RS06480	COG2321	neutral zinc metallopeptidase
GK046_RS06500	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GK046_RS06510	COG2716	regulation of RNA biosynthetic process
GK046_RS06515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GK046_RS06520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS06530	COG0650	Formate hydrogenlyase subunit 4
GK046_RS06535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GK046_RS06545	COG4237	Hydrogenase 4 membrane
GK046_RS06550	COG0651	ATP synthesis coupled electron transport
GK046_RS06555	COG3261	NADH dehydrogenase
GK046_RS06555	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GK046_RS06560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GK046_RS06565	COG3260	NADH ubiquinone oxidoreductase 20
GK046_RS06575	COG3604	Transcriptional regulator
GK046_RS06580	COG2116	formate transmembrane transporter activity
GK046_RS06585	COG2116	formate transmembrane transporter activity
GK046_RS06590	COG0628	permease
GK046_RS06595	COG4783	chaperone-mediated protein folding
GK046_RS06600	COG1393	Belongs to the ArsC family
GK046_RS06610	COG2233	PERMEase
GK046_RS06625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GK046_RS06630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GK046_RS06635	COG0248	Ppx GppA phosphatase
GK046_RS06640	COG2200	EAL domain
GK046_RS06650	COG3133	Outer membrane lipoprotein
GK046_RS06705	COG3093	addiction module antidote protein HigA
GK046_RS06710	COG3846	protein secretion by the type IV secretion system
GK046_RS06750	COG0582	viral genome integration into host DNA
GK046_RS06760	COG0517	IMP dehydrogenase activity
GK046_RS06760	COG0516	GMP reductase activity
GK046_RS06770	COG1645	bacterial-type flagellum-dependent swarming motility
GK046_RS06785	COG2976	Protein conserved in bacteria
GK046_RS06815	COG4953	penicillin-binding protein 1C
GK046_RS06820	COG2373	Large extracellular alpha-helical protein
GK046_RS06825	COG2897	thiosulfate sulfurtransferase activity
GK046_RS06840	COG2975	iron-sulfur cluster assembly
GK046_RS06845	COG0633	Ferredoxin
GK046_RS06865	COG0822	iron-sulfur transferase activity
GK046_RS06885	COG0483	inositol monophosphate 1-phosphatase activity
GK046_RS06890	COG1073	alpha beta
GK046_RS06895	COG3711	transcriptional antiterminator
GK046_RS06900	COG2814	Major facilitator Superfamily
GK046_RS06905	COG0583	DNA-binding transcription factor activity
GK046_RS06910	COG4638	Rieske (2fe-2S)
GK046_RS06935	COG2259	Doxx family
GK046_RS06940	COG2017	converts alpha-aldose to the beta-anomer
GK046_RS06945	COG1063	alcohol dehydrogenase
GK046_RS06950	COG1172	Belongs to the binding-protein-dependent transport system permease family
GK046_RS06955	COG1129	ABC transporter
GK046_RS06960	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS06965	COG0457	Tetratricopeptide repeat
GK046_RS06970	COG1940	carbohydrate kinase activity
GK046_RS06980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GK046_RS06980	COG1017	nitric oxide dioxygenase activity
GK046_RS06985	COG0347	Belongs to the P(II) protein family
GK046_RS06990	COG2204	response regulator
GK046_RS06995	COG3170	Tfp pilus assembly protein FimV
GK046_RS07000	COG2205	protein histidine kinase activity
GK046_RS07020	COG0560	Phosphoserine phosphatase
GK046_RS07025	COG1737	Transcriptional regulator
GK046_RS07030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS07045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GK046_RS07065	COG0681	Belongs to the peptidase S26 family
GK046_RS07075	COG3086	response to oxidative stress
GK046_RS07080	COG3026	antisigma factor binding
GK046_RS07085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GK046_RS07090	COG1595	DNA-templated transcription, initiation
GK046_RS07100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GK046_RS07110	COG0513	Belongs to the DEAD box helicase family
GK046_RS07115	COG0583	DNA-binding transcription factor activity
GK046_RS07135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GK046_RS07140	COG3118	belongs to the thioredoxin family
GK046_RS07145	COG3148	PFAM DTW domain containing protein
GK046_RS07150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GK046_RS07150	COG0045	succinate-CoA ligase (ADP-forming) activity
GK046_RS07150	COG1042	CoA-binding domain protein
GK046_RS07155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GK046_RS07160	COG5544	Lipoprotein
GK046_RS07165	COG0477	Major facilitator Superfamily
GK046_RS07190	COG0542	response to heat
GK046_RS07195	COG1496	oxidoreductase activity
GK046_RS07200	COG0564	pseudouridine synthase activity
GK046_RS07205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GK046_RS07210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GK046_RS07220	COG1605	Chorismate mutase
GK046_RS07220	COG0077	Prephenate dehydratase
GK046_RS07225	COG0287	Prephenate dehydrogenase
GK046_RS07225	COG1605	Chorismate mutase
GK046_RS07230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GK046_RS07245	COG2199	diguanylate cyclase activity
GK046_RS07250	COG2885	chlorophyll binding
GK046_RS07275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GK046_RS07280	COG4137	Cytochrome C assembly protein
GK046_RS07285	COG4536	flavin adenine dinucleotide binding
GK046_RS07300	COG0497	DNA recombination
GK046_RS07305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GK046_RS07315	COG2867	negative regulation of translational initiation
GK046_RS07330	COG0582	viral genome integration into host DNA
GK046_RS07380	COG3311	Transcriptional regulator
GK046_RS07385	COG3596	GTP binding
GK046_RS07420	COG0366	Alpha amylase catalytic
GK046_RS07430	COG0579	oxidoreductase
GK046_RS07435	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS07440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GK046_RS07445	COG1113	amino acid transport
GK046_RS07450	COG1802	Transcriptional regulator
GK046_RS07455	COG1652	LysM domain
GK046_RS07460	COG0401	homolog of Blt101
GK046_RS07465	COG0640	Transcriptional regulator
GK046_RS07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GK046_RS07475	COG2916	Histone family protein nucleoid-structuring protein H-NS
GK046_RS07490	COG4575	ribosome binding
GK046_RS07495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GK046_RS07505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GK046_RS07510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GK046_RS07515	COG4175	Glycine betaine
GK046_RS07520	COG4176	ABC-type proline glycine betaine transport system permease component
GK046_RS07525	COG2113	Glycine betaine
GK046_RS07530	COG2814	Major facilitator Superfamily
GK046_RS07535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GK046_RS07545	COG1846	Transcriptional regulator
GK046_RS07550	COG1566	PFAM secretion protein HlyD family protein
GK046_RS07555	COG2814	Major facilitator Superfamily
GK046_RS07570	COG1238	metal cluster binding
GK046_RS07575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GK046_RS07605	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GK046_RS07625	COG1546	Belongs to the CinA family
GK046_RS07630	COG2951	lytic endotransglycosylase activity
GK046_RS07635	COG3730	PTS system glucitol sorbitol-specific
GK046_RS07640	COG3732	PTS system glucitol sorbitol-specific
GK046_RS07645	COG3731	PTS system glucitol sorbitol-specific IIA component
GK046_RS07650	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS07655	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS07660	COG1349	DNA-binding transcription factor activity
GK046_RS07685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GK046_RS07690	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS07695	COG1609	Transcriptional regulator
GK046_RS07700	COG1263	PTS System
GK046_RS07700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS07705	COG2723	6-phospho-beta-galactosidase activity
GK046_RS07710	COG5499	transcription regulator containing HTH domain
GK046_RS07720	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GK046_RS07730	COG3260	NADH ubiquinone oxidoreductase 20
GK046_RS07735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GK046_RS07740	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GK046_RS07740	COG3261	NADH dehydrogenase
GK046_RS07745	COG0650	Formate hydrogenlyase subunit 4
GK046_RS07750	COG0651	ATP synthesis coupled electron transport
GK046_RS07755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS07770	COG0375	protein maturation
GK046_RS07775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GK046_RS07780	COG0298	carbon dioxide binding
GK046_RS07785	COG0409	Hydrogenase expression formation protein
GK046_RS07790	COG0309	Hydrogenase expression formation protein (HypE)
GK046_RS07795	COG3604	Transcriptional regulator
GK046_RS07810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GK046_RS07815	COG1349	DNA-binding transcription factor activity
GK046_RS07820	COG2084	Dehydrogenase
GK046_RS07825	COG3395	kinase activity
GK046_RS07830	COG0235	Class ii aldolase
GK046_RS07835	COG3622	Belongs to the hyi family
GK046_RS07840	COG2610	gluconate transmembrane transporter activity
GK046_RS07865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GK046_RS07870	COG1388	LysM domain
GK046_RS07870	COG4942	peptidase
GK046_RS07925	COG2234	aminopeptidase activity
GK046_RS07930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GK046_RS07935	COG1518	maintenance of DNA repeat elements
GK046_RS07950	COG1857	crispr-associated protein
GK046_RS07965	COG1203	CRISPR-associated helicase, Cas3
GK046_RS07970	COG3385	transposase activity
GK046_RS07995	COG0720	synthase
GK046_RS08005	COG0602	queuosine metabolic process
GK046_RS08050	COG3956	TIGRFAM MazG family protein
GK046_RS08055	COG2337	Toxic component of a toxin-antitoxin (TA) module
GK046_RS08060	COG2336	PFAM SpoVT AbrB
GK046_RS08065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GK046_RS08075	COG4999	Histidine kinase
GK046_RS08075	COG3850	Histidine kinase
GK046_RS08075	COG3437	response regulator, receiver
GK046_RS08075	COG2205	protein histidine kinase activity
GK046_RS08080	COG4948	Mandelate Racemase Muconate Lactonizing
GK046_RS08085	COG4948	Mandelate Racemase Muconate Lactonizing
GK046_RS08090	COG2271	Major facilitator Superfamily
GK046_RS08095	COG0716	FMN binding
GK046_RS08100	COG0564	pseudouridine synthase activity
GK046_RS08105	COG3098	single-species biofilm formation
GK046_RS08120	COG1611	Belongs to the LOG family
GK046_RS08125	COG0814	amino acid
GK046_RS08130	COG1760	l-serine dehydratase
GK046_RS08140	COG1454	alcohol dehydrogenase
GK046_RS08145	COG0235	Class ii aldolase
GK046_RS08150	COG0738	Major facilitator superfamily
GK046_RS08160	COG1070	Carbohydrate kinase
GK046_RS08170	COG1349	DNA-binding transcription factor activity
GK046_RS08180	COG2363	Small membrane protein
GK046_RS08185	COG0583	DNA-binding transcription factor activity
GK046_RS08195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GK046_RS08200	COG2166	iron-sulfur cluster assembly
GK046_RS08205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GK046_RS08210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GK046_RS08230	COG0860	N-Acetylmuramoyl-L-alanine amidase
GK046_RS08235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GK046_RS08235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GK046_RS08240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GK046_RS08245	COG1074	ATP-dependent DNA helicase activity
GK046_RS08250	COG1025	Belongs to the peptidase M16 family
GK046_RS08255	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GK046_RS08260	COG4967	type IV pilus modification protein PilV
GK046_RS08270	COG4795	General secretion pathway protein
GK046_RS08275	COG2165	general secretion pathway protein
GK046_RS08290	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GK046_RS08305	COG0861	Integral membrane protein TerC family
GK046_RS08315	COG0667	Aldo Keto reductase
GK046_RS08330	COG1609	Transcriptional regulator
GK046_RS08340	COG0583	DNA-binding transcription factor activity
GK046_RS08345	COG1794	racemase activity, acting on amino acids and derivatives
GK046_RS08350	COG2814	Major facilitator Superfamily
GK046_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS08365	COG0183	Belongs to the thiolase family
GK046_RS08370	COG0814	amino acid
GK046_RS08375	COG2771	luxR family
GK046_RS08380	COG3710	Transcriptional regulator
GK046_RS08405	COG0457	Tetratricopeptide repeat
GK046_RS08410	COG3710	Transcriptional regulator
GK046_RS08410	COG0457	Tetratricopeptide repeat
GK046_RS08505	COG3387	PFAM Glycoside hydrolase 15-related
GK046_RS08515	COG4942	peptidase
GK046_RS08520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GK046_RS08525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GK046_RS08530	COG2080	2 iron, 2 sulfur cluster binding
GK046_RS08535	COG3829	transcription factor binding
GK046_RS08540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GK046_RS08545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GK046_RS08550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GK046_RS08560	COG0549	Belongs to the carbamate kinase family
GK046_RS08565	COG3608	succinylglutamate desuccinylase aspartoacylase
GK046_RS08565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GK046_RS08570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GK046_RS08575	COG2068	MobA-Related Protein
GK046_RS08580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS08580	COG0493	'glutamate synthase
GK046_RS08585	COG0402	S-adenosylhomocysteine deaminase activity
GK046_RS08590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GK046_RS08595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GK046_RS08595	COG2080	2 iron, 2 sulfur cluster binding
GK046_RS08600	COG2233	PERMEase
GK046_RS08605	COG0402	S-adenosylhomocysteine deaminase activity
GK046_RS08610	COG2252	PERMEase
GK046_RS08615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS08620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS08620	COG0493	'glutamate synthase
GK046_RS08625	COG2233	PERMEase
GK046_RS08655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GK046_RS08660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GK046_RS08665	COG4974	Belongs to the 'phage' integrase family
GK046_RS08670	COG0716	FMN binding
GK046_RS08680	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GK046_RS08690	COG1272	protein, Hemolysin III
GK046_RS08700	COG2723	6-phospho-beta-galactosidase activity
GK046_RS08705	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS08730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GK046_RS08735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GK046_RS08740	COG0006	proline dipeptidase activity
GK046_RS08760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GK046_RS08775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GK046_RS08795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GK046_RS08795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GK046_RS08800	COG1703	isobutyryl-CoA mutase activity
GK046_RS08805	COG1024	Enoyl-CoA hydratase
GK046_RS08810	COG0427	acetyl-CoA hydrolase
GK046_RS08815	COG0583	DNA-binding transcription factor activity
GK046_RS08820	COG2968	Membrane
GK046_RS08830	COG0668	transmembrane transport
GK046_RS08835	COG0191	fructose-bisphosphate aldolase activity
GK046_RS08865	COG1122	ATPase activity
GK046_RS08870	COG1122	ATPase activity
GK046_RS08875	COG1072	(Pantothenic acid kinase))
GK046_RS08885	COG1494	fructose-1,6-bisphosphatase
GK046_RS08890	COG1063	alcohol dehydrogenase
GK046_RS08895	COG2213	PTS system mannitol-specific
GK046_RS08900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS08905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GK046_RS08910	COG0501	Belongs to the peptidase M48B family
GK046_RS08925	COG1166	arginine decarboxylase activity
GK046_RS08940	COG2814	Major facilitator Superfamily
GK046_RS08950	COG2356	endonuclease I
GK046_RS08955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GK046_RS08960	COG0189	ligase activity
GK046_RS08975	COG2805	Type II/IV secretion system protein
GK046_RS08980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GK046_RS08985	COG0762	integral membrane protein
GK046_RS09000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GK046_RS09005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GK046_RS09010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GK046_RS09025	COG0252	asparaginase activity
GK046_RS09035	COG3171	Protein conserved in bacteria
GK046_RS09045	COG1194	a g-specific adenine glycosylase
GK046_RS09060	COG2211	Major facilitator Superfamily
GK046_RS09065	COG1982	Orn Lys Arg decarboxylase major
GK046_RS09070	COG1811	Na channel or pump
GK046_RS09080	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GK046_RS09110	COG2165	general secretion pathway protein
GK046_RS09115	COG1459	type II secretion system
GK046_RS09120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GK046_RS09145	COG3064	Membrane
GK046_RS09150	COG1620	l-lactate permease
GK046_RS09155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GK046_RS09160	COG3193	protein, possibly involved in utilization of glycolate and propanediol
GK046_RS09165	COG0247	lactate metabolic process
GK046_RS09170	COG0277	FAD linked oxidase domain protein
GK046_RS09175	COG0277	FAD linked oxidase domain protein
GK046_RS09180	COG2186	Transcriptional regulator
GK046_RS09185	COG0456	acetyltransferase
GK046_RS09190	COG0318	PFAM AMP-dependent synthetase and ligase
GK046_RS09200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GK046_RS09205	COG0156	8-amino-7-oxononanoate synthase activity
GK046_RS09215	COG0795	lipopolysaccharide-transporting ATPase activity
GK046_RS09220	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GK046_RS09230	COG2244	polysaccharide biosynthetic process
GK046_RS09235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GK046_RS09240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GK046_RS09245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GK046_RS09250	COG0306	phosphate transporter
GK046_RS09255	COG0754	glutathionylspermidine amidase activity
GK046_RS09260	COG0625	glutathione transferase activity
GK046_RS09265	COG0298	carbon dioxide binding
GK046_RS09275	COG1773	rubredoxin
GK046_RS09280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GK046_RS09285	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GK046_RS09290	COG5557	Pfam Polysulphide reductase, NrfD
GK046_RS09295	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS09300	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GK046_RS09315	COG0667	Aldo Keto reductase
GK046_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS09330	COG0848	biopolymer transport protein
GK046_RS09335	COG0811	peptide transport
GK046_RS09340	COG0626	cystathionine gamma-synthase activity
GK046_RS09345	COG0586	Pfam SNARE associated Golgi protein
GK046_RS09350	COG2207	Transcriptional regulator
GK046_RS09355	COG1979	alcohol dehydrogenase
GK046_RS09360	COG0656	L-ascorbic acid biosynthetic process
GK046_RS09370	COG4238	major outer membrane lipoprotein
GK046_RS09375	COG1032	radical SAM domain protein
GK046_RS09380	COG2132	Multicopper oxidase
GK046_RS09385	COG0204	Acyl-transferase
GK046_RS09390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GK046_RS09395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GK046_RS09400	COG3111	PFAM Bacterial OB fold (BOF) protein
GK046_RS09405	COG0745	RESPONSE REGULATOR receiver
GK046_RS09410	COG0642	Histidine kinase
GK046_RS09420	COG2249	NAD(P)H dehydrogenase (quinone) activity
GK046_RS09425	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GK046_RS09430	COG0187	DNA topoisomerase II activity
GK046_RS09435	COG3150	esterase
GK046_RS09440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GK046_RS09445	COG3151	Protein conserved in bacteria
GK046_RS09450	COG0494	nUDIX hydrolase
GK046_RS09455	COG1538	Outer membrane efflux protein
GK046_RS09465	COG0754	glutathionylspermidine amidase activity
GK046_RS09470	COG3384	dioxygenase
GK046_RS09490	COG2960	long-chain fatty acid transporting porin activity
GK046_RS09495	COG3539	Fimbrial protein
GK046_RS09500	COG3188	usher protein
GK046_RS09505	COG3121	Chaperone
GK046_RS09510	COG3539	Fimbrial protein
GK046_RS09520	COG1585	Membrane protein implicated in regulation of membrane protease activity
GK046_RS09525	COG2268	Band 7 protein
GK046_RS09550	COG3025	triphosphatase activity
GK046_RS09555	COG4991	sh3 domain protein
GK046_RS09570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GK046_RS09580	COG0583	DNA-binding transcription factor activity
GK046_RS09585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GK046_RS09590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GK046_RS09605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GK046_RS09610	COG0358	DNA primase activity
GK046_RS09615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GK046_RS09630	COG2375	cellular response to nickel ion
GK046_RS09635	COG1695	Transcriptional regulator
GK046_RS09640	COG0840	transmembrane signaling receptor activity
GK046_RS09650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GK046_RS09655	COG1609	Transcriptional regulator
GK046_RS09660	COG3250	beta-galactosidase activity
GK046_RS09665	COG2731	YhcH YjgK YiaL family protein
GK046_RS09670	COG0531	amino acid
GK046_RS09680	COG3408	Glycogen debranching enzyme
GK046_RS09680	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GK046_RS09685	COG1902	pentaerythritol trinitrate reductase activity
GK046_RS09685	COG0446	pyridine nucleotide-disulphide oxidoreductase
GK046_RS09690	COG5499	transcription regulator containing HTH domain
GK046_RS09705	COG1451	nucleotide metabolic process
GK046_RS09710	COG2949	membrane
GK046_RS09715	COG0673	inositol 2-dehydrogenase activity
GK046_RS09720	COG0861	Integral membrane protein TerC family
GK046_RS09725	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GK046_RS09735	COG2721	sulfolactate sulfo-lyase activity
GK046_RS09745	COG2271	Major facilitator Superfamily
GK046_RS09775	COG2186	Transcriptional regulator
GK046_RS09780	COG0586	Pfam SNARE associated Golgi protein
GK046_RS09790	COG1422	Protein of unknown function (DUF1090)
GK046_RS09795	COG4575	ribosome binding
GK046_RS09800	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
GK046_RS09810	COG2259	Doxx family
GK046_RS09815	COG0435	Glutathione S-transferase
GK046_RS09820	COG3152	Membrane
GK046_RS09825	COG3152	Membrane
GK046_RS09830	COG0583	DNA-binding transcription factor activity
GK046_RS09835	COG1741	Belongs to the pirin family
GK046_RS09850	COG0814	amino acid
GK046_RS09855	COG1760	l-serine dehydratase
GK046_RS09860	COG0251	oxidation-reduction process
GK046_RS09865	COG1882	Formate acetyltransferase
GK046_RS09870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GK046_RS09880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GK046_RS09885	COG0583	DNA-binding transcription factor activity
GK046_RS09910	COG1929	Belongs to the glycerate kinase type-1 family
GK046_RS09915	COG2084	Dehydrogenase
GK046_RS09925	COG2271	Major facilitator Superfamily
GK046_RS09930	COG2721	sulfolactate sulfo-lyase activity
GK046_RS09935	COG2002	toxin-antitoxin pair type II binding
GK046_RS09945	COG1349	DNA-binding transcription factor activity
GK046_RS09955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS09965	COG3716	PTS system mannose fructose sorbose family IID component
GK046_RS09970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS09975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GK046_RS09980	COG2222	sugar isomerase
GK046_RS09990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS09995	COG3715	PTS system
GK046_RS10000	COG3716	PTS system mannose fructose sorbose family IID component
GK046_RS10005	COG0363	glucosamine-6-phosphate deaminase activity
GK046_RS10010	COG3539	Fimbrial protein
GK046_RS10015	COG3121	Chaperone
GK046_RS10020	COG3188	usher protein
GK046_RS10025	COG3539	Fimbrial protein
GK046_RS10030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GK046_RS10050	COG2823	Periplasmic or secreted lipoprotein
GK046_RS10055	COG0701	Predicted permease
GK046_RS10060	COG0702	epimerase
GK046_RS10065	COG0693	protein deglycase activity
GK046_RS10080	COG3153	acetyltransferase
GK046_RS10085	COG3154	lipid carrier protein
GK046_RS10090	COG0826	peptidase U32
GK046_RS10095	COG0826	peptidase U32
GK046_RS10100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GK046_RS10105	COG0814	amino acid
GK046_RS10110	COG0513	Belongs to the DEAD box helicase family
GK046_RS10150	COG0195	Participates in both transcription termination and antitermination
GK046_RS10170	COG2194	sulfuric ester hydrolase activity
GK046_RS10180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GK046_RS10190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GK046_RS10195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GK046_RS10205	COG1534	Rna-binding protein
GK046_RS10210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GK046_RS10215	COG2027	D-alanyl-D-alanine carboxypeptidase
GK046_RS10225	COG0697	spore germination
GK046_RS10240	COG0142	geranyltranstransferase activity
GK046_RS10245	COG3423	Transcriptional regulator
GK046_RS10255	COG5007	Belongs to the BolA IbaG family
GK046_RS10260	COG3113	response to antibiotic
GK046_RS10265	COG2854	intermembrane phospholipid transfer
GK046_RS10270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GK046_RS10275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GK046_RS10280	COG1127	ABC transporter
GK046_RS10285	COG0530	calcium, potassium:sodium antiporter activity
GK046_RS10290	COG0517	IMP dehydrogenase activity
GK046_RS10290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GK046_RS10295	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GK046_RS10300	COG3117	lipopolysaccharide transmembrane transporter activity
GK046_RS10305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GK046_RS10310	COG1137	ATPase activity
GK046_RS10315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GK046_RS10320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GK046_RS10335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS10340	COG0515	serine threonine protein kinase
GK046_RS10350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GK046_RS10355	COG2198	Histidine kinase
GK046_RS10355	COG0784	Response regulator, receiver
GK046_RS10355	COG5002	protein histidine kinase activity
GK046_RS10360	COG1242	4 iron, 4 sulfur cluster binding
GK046_RS10365	COG0070	glutamate synthase
GK046_RS10365	COG0069	glutamate synthase activity
GK046_RS10365	COG0067	glutamate synthase
GK046_RS10370	COG0493	'glutamate synthase
GK046_RS10375	COG4804	nuclease activity
GK046_RS10385	COG2731	YhcH YjgK YiaL family protein
GK046_RS10415	COG3069	C4-dicarboxylate transmembrane transporter activity
GK046_RS10420	COG2969	positive regulation of protein catabolic process
GK046_RS10425	COG0625	glutathione transferase activity
GK046_RS10440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GK046_RS10445	COG3105	Protein conserved in bacteria
GK046_RS10450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GK046_RS10455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GK046_RS10475	COG2732	(Barnase) inhibitor
GK046_RS10495	COG0583	DNA-binding transcription factor activity
GK046_RS10500	COG0312	modulator of DNA gyrase
GK046_RS10505	COG3164	Protein of unknown function
GK046_RS10510	COG1530	ribonuclease E activity
GK046_RS10520	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GK046_RS10525	COG1792	Involved in formation and maintenance of cell shape
GK046_RS10530	COG1077	Cell shape determining protein MreB Mrl
GK046_RS10535	COG2200	EAL domain
GK046_RS10535	COG2199	diguanylate cyclase activity
GK046_RS10540	COG0604	alcohol dehydrogenase
GK046_RS10545	COG0511	ligase activity, forming carbon-carbon bonds
GK046_RS10550	COG0439	Biotin carboxylase
GK046_RS10555	COG3924	membrane
GK046_RS10560	COG4145	pantothenate transmembrane transporter activity
GK046_RS10570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GK046_RS10580	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GK046_RS10590	COG1309	transcriptional regulator
GK046_RS10595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS10600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GK046_RS10610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS10615	COG4597	amino acid ABC transporter
GK046_RS10620	COG0765	amino acid transport
GK046_RS10625	COG1126	abc transporter atp-binding protein
GK046_RS10665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GK046_RS10685	COG0551	DNA topoisomerase type I activity
GK046_RS10695	COG0758	DNA mediated transformation
GK046_RS10715	COG0569	domain protein
GK046_RS10725	COG3036	rescue of stalled ribosome
GK046_RS10730	COG0789	Transcriptional regulator
GK046_RS10770	COG0201	protein transport
GK046_RS10860	COG0089	rRNA binding
GK046_RS10930	COG2964	Protein conserved in bacteria
GK046_RS10935	COG0545	Peptidyl-prolyl cis-trans isomerase
GK046_RS10945	COG1047	Peptidyl-prolyl cis-trans
GK046_RS10950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GK046_RS10965	COG0488	(ABC) transporter
GK046_RS10970	COG0429	hydrolase of the alpha beta-hydrolase fold
GK046_RS10980	COG3954	Phosphoribulokinase
GK046_RS10985	COG1765	OsmC-like protein
GK046_RS10990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GK046_RS10995	COG1289	transmembrane transporter activity
GK046_RS11000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GK046_RS11005	COG0512	Glutamine amidotransferase of anthranilate synthase
GK046_RS11010	COG2184	nucleotidyltransferase activity
GK046_RS11020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GK046_RS11030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GK046_RS11035	COG2146	nitrite reductase [NAD(P)H] activity
GK046_RS11040	COG2116	formate transmembrane transporter activity
GK046_RS11055	COG0531	amino acid
GK046_RS11060	COG2222	sugar isomerase
GK046_RS11065	COG1082	Xylose isomerase domain protein TIM barrel
GK046_RS11075	COG2188	Transcriptional regulator
GK046_RS11080	COG0626	cystathionine gamma-synthase activity
GK046_RS11095	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GK046_RS11100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GK046_RS11105	COG3457	Alanine racemase
GK046_RS11115	COG2188	Transcriptional regulator
GK046_RS11120	COG0180	Tryptophanyl-tRNA synthetase
GK046_RS11125	COG0546	phosphoglycolate phosphatase activity
GK046_RS11130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GK046_RS11135	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GK046_RS11140	COG3266	domain, Protein
GK046_RS11155	COG4796	Type ii and iii secretion system protein
GK046_RS11170	COG3166	PFAM Fimbrial assembly family protein
GK046_RS11175	COG4972	Pilus assembly protein
GK046_RS11180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GK046_RS11185	COG0494	nUDIX hydrolase
GK046_RS11195	COG1011	Hydrolase
GK046_RS11200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GK046_RS11210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GK046_RS11230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GK046_RS11235	COG2183	response to ionizing radiation
GK046_RS11240	COG1918	ferrous iron import across plasma membrane
GK046_RS11245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GK046_RS11275	COG2610	gluconate transmembrane transporter activity
GK046_RS11280	COG1640	4-alpha-glucanotransferase
GK046_RS11285	COG0058	SHG alpha-glucan phosphorylase activity
GK046_RS11300	COG1690	Belongs to the RtcB family
GK046_RS11305	COG4650	regulator
GK046_RS11310	COG1349	DNA-binding transcription factor activity
GK046_RS11325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GK046_RS11345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GK046_RS11350	COG0058	SHG alpha-glucan phosphorylase activity
GK046_RS11375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GK046_RS11380	COG2095	MarC family integral membrane protein
GK046_RS11385	COG2610	gluconate transmembrane transporter activity
GK046_RS11390	COG3265	gluconokinase activity
GK046_RS11395	COG1609	Transcriptional regulator
GK046_RS11405	COG1741	Belongs to the pirin family
GK046_RS11410	COG0673	inositol 2-dehydrogenase activity
GK046_RS11415	COG1247	-acetyltransferase
GK046_RS11420	COG3157	Type VI secretion system effector, Hcp
GK046_RS11445	COG0405	Gamma-glutamyltransferase
GK046_RS11455	COG0584	glycerophosphoryl diester phosphodiesterase
GK046_RS11460	COG3842	ATPase activity
GK046_RS11465	COG0395	ABC-type sugar transport system, permease component
GK046_RS11470	COG1175	transmembrane transport
GK046_RS11475	COG1653	transport
GK046_RS11490	COG0410	ABC transporter
GK046_RS11495	COG0411	ABC transporter
GK046_RS11500	COG4177	L-phenylalanine transmembrane transporter activity
GK046_RS11505	COG0559	Belongs to the binding-protein-dependent transport system permease family
GK046_RS11510	COG0683	leucine binding
GK046_RS11515	COG0456	acetyltransferase
GK046_RS11520	COG0683	leucine binding
GK046_RS11525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GK046_RS11530	COG2177	Part of the ABC transporter FtsEX involved in
GK046_RS11535	COG2884	Cell division ATP-binding protein ftsE
GK046_RS11540	COG0552	protein localization to endoplasmic reticulum
GK046_RS11545	COG0742	ribosomal rna small subunit methyltransferase
GK046_RS11550	COG3776	membrane
GK046_RS11560	COG3714	YhhN family
GK046_RS11575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GK046_RS11590	COG0628	permease
GK046_RS11595	COG2091	lysine biosynthetic process via aminoadipic acid
GK046_RS11600	COG0747	negative chemotaxis
GK046_RS11605	COG0601	transmembrane transport
GK046_RS11610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GK046_RS11615	COG0444	Belongs to the ABC transporter superfamily
GK046_RS11640	COG0842	Transport permease protein
GK046_RS11645	COG0842	Transport permease protein
GK046_RS11645	COG1129	ABC transporter
GK046_RS11650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS11670	COG2081	HI0933 family
GK046_RS11675	COG0306	phosphate transporter
GK046_RS11685	COG0589	response to stress
GK046_RS11690	COG3104	oligopeptide transport
GK046_RS11700	COG0339	signal peptide processing
GK046_RS11705	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GK046_RS11710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GK046_RS11720	COG0640	Transcriptional regulator
GK046_RS11725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GK046_RS11730	COG1393	Belongs to the ArsC family
GK046_RS11750	COG3065	identical protein binding
GK046_RS11755	COG2197	response regulator
GK046_RS11760	COG1285	pathogenesis
GK046_RS11775	COG3247	response to pH
GK046_RS11780	COG2771	luxR family
GK046_RS11790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS11795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GK046_RS11800	COG2207	Transcriptional regulator
GK046_RS11810	COG0076	glutamate decarboxylase activity
GK046_RS11815	COG1858	cytochrome C peroxidase
GK046_RS11825	COG2197	response regulator
GK046_RS11830	COG0583	DNA-binding transcription factor activity
GK046_RS11835	COG1295	ribonuclease BN
GK046_RS11840	COG0477	Major facilitator Superfamily
GK046_RS11845	COG2982	Protein involved in outer membrane biogenesis
GK046_RS11850	COG2200	EAL domain
GK046_RS11860	COG0612	Peptidase, M16
GK046_RS11870	COG2199	diguanylate cyclase activity
GK046_RS11870	COG2200	EAL domain
GK046_RS11875	COG0457	Tetratricopeptide repeat
GK046_RS11875	COG3118	belongs to the thioredoxin family
GK046_RS11880	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GK046_RS11890	COG1215	transferase activity, transferring glycosyl groups
GK046_RS11915	COG2194	sulfuric ester hydrolase activity
GK046_RS11935	COG0814	amino acid
GK046_RS11940	COG4608	Belongs to the ABC transporter superfamily
GK046_RS11945	COG0444	Belongs to the ABC transporter superfamily
GK046_RS11950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GK046_RS11955	COG0601	transmembrane transport
GK046_RS11960	COG0747	negative chemotaxis
GK046_RS11975	COG2194	sulfuric ester hydrolase activity
GK046_RS12005	COG2223	nitrite transmembrane transporter activity
GK046_RS12010	COG5571	outer membrane autotransporter
GK046_RS12015	COG2818	Glycosylase
GK046_RS12020	COG0456	acetyltransferase
GK046_RS12025	COG0243	molybdopterin cofactor binding
GK046_RS12030	COG2885	chlorophyll binding
GK046_RS12045	COG2944	sequence-specific DNA binding
GK046_RS12050	COG1278	Cold shock
GK046_RS12075	COG3274	enterobacterial common antigen metabolic process
GK046_RS12080	COG4682	membrane
GK046_RS12085	COG4682	membrane
GK046_RS12090	COG1070	Carbohydrate kinase
GK046_RS12100	COG4213	ABC transporter substrate-binding protein
GK046_RS12105	COG1129	ABC transporter
GK046_RS12110	COG4214	carbohydrate transport
GK046_RS12115	COG1609	Transcriptional regulator
GK046_RS12115	COG2207	Transcriptional regulator
GK046_RS12120	COG2992	FlgJ-related protein
GK046_RS12125	COG0366	Alpha amylase catalytic
GK046_RS12130	COG3977	Valine--pyruvate aminotransferase
GK046_RS12135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GK046_RS12140	COG1414	Transcriptional regulator
GK046_RS12150	COG2731	YhcH YjgK YiaL family protein
GK046_RS12155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GK046_RS12160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GK046_RS12165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GK046_RS12170	COG1070	Carbohydrate kinase
GK046_RS12175	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GK046_RS12180	COG3623	hexulose-6-phosphate isomerase
GK046_RS12185	COG0235	Class ii aldolase
GK046_RS12195	COG2211	Major facilitator Superfamily
GK046_RS12205	COG3713	MltA-interacting MipA family protein
GK046_RS12210	COG0583	DNA-binding transcription factor activity
GK046_RS12215	COG1566	PFAM secretion protein HlyD family protein
GK046_RS12230	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS12235	COG1454	alcohol dehydrogenase
GK046_RS12240	COG3276	selenocysteine insertion sequence binding
GK046_RS12250	COG0625	glutathione transferase activity
GK046_RS12255	COG3209	COG3209 Rhs family protein
GK046_RS12265	COG1413	lyase activity
GK046_RS12270	COG3209	COG3209 Rhs family protein
GK046_RS12275	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GK046_RS12285	COG1566	PFAM secretion protein HlyD family protein
GK046_RS12295	COG2213	PTS system mannitol-specific
GK046_RS12295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS12305	COG3722	fumarate hydratase activity
GK046_RS12325	COG5295	Hep Hag repeat protein
GK046_RS12330	COG1620	l-lactate permease
GK046_RS12335	COG2186	Transcriptional regulator
GK046_RS12345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GK046_RS12350	COG1045	serine acetyltransferase
GK046_RS12365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GK046_RS12370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GK046_RS12380	COG4942	peptidase
GK046_RS12385	COG2861	carbohydrate metabolic process
GK046_RS12390	COG1216	Glycosyl transferase, family 2
GK046_RS12400	COG0156	8-amino-7-oxononanoate synthase activity
GK046_RS12415	COG0859	PFAM glycosyl transferase family 9
GK046_RS12420	COG0859	PFAM glycosyl transferase family 9
GK046_RS12440	COG3642	lipopolysaccharide core region biosynthetic process
GK046_RS12450	COG0515	serine threonine protein kinase
GK046_RS12455	COG0438	transferase activity, transferring glycosyl groups
GK046_RS12460	COG0859	PFAM glycosyl transferase family 9
GK046_RS12465	COG1519	Transferase
GK046_RS12495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GK046_RS12520	COG1561	YicC-like family, N-terminal region
GK046_RS12525	COG3645	SOS response
GK046_RS12530	COG2860	membrane
GK046_RS12540	COG0194	GDP metabolic process
GK046_RS12550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GK046_RS12555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GK046_RS12560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GK046_RS12570	COG0786	glutamate:sodium symporter activity
GK046_RS12575	COG2233	PERMEase
GK046_RS12580	COG2982	Protein involved in outer membrane biogenesis
GK046_RS12585	COG1501	Belongs to the glycosyl hydrolase 31 family
GK046_RS12590	COG2211	Major facilitator Superfamily
GK046_RS12600	COG0582	viral genome integration into host DNA
GK046_RS12610	COG1609	Transcriptional regulator
GK046_RS12615	COG2271	Major facilitator Superfamily
GK046_RS12650	COG2003	Belongs to the UPF0758 family
GK046_RS12695	COG2814	Major facilitator Superfamily
GK046_RS12700	COG0697	spore germination
GK046_RS12705	COG1464	Belongs to the NlpA lipoprotein family
GK046_RS12725	COG2252	PERMEase
GK046_RS12735	COG2271	Major facilitator Superfamily
GK046_RS12740	COG2271	Major facilitator Superfamily
GK046_RS12745	COG3851	Histidine kinase
GK046_RS12750	COG2197	response regulator
GK046_RS12755	COG0440	acetolactate synthase activity
GK046_RS12760	COG0028	Belongs to the TPP enzyme family
GK046_RS12775	COG2814	Major facilitator Superfamily
GK046_RS12780	COG0641	radical SAM
GK046_RS12790	COG2149	membrane
GK046_RS12800	COG3119	arylsulfatase activity
GK046_RS12805	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GK046_RS12810	COG2207	Transcriptional regulator
GK046_RS12830	COG2188	Transcriptional regulator
GK046_RS12850	COG5645	(Lipo)protein
GK046_RS12855	COG0823	Involved in the tonB-independent uptake of proteins
GK046_RS12865	COG2271	Major facilitator Superfamily
GK046_RS12875	COG0800	Aldolase
GK046_RS12880	COG3734	2-keto-3-deoxy-galactonokinase
GK046_RS12885	COG2186	Transcriptional regulator
GK046_RS12895	COG0561	phosphatase activity
GK046_RS12900	COG3753	Protein conserved in bacteria
GK046_RS12905	COG0187	DNA topoisomerase II activity
GK046_RS12915	COG0592	DNA-directed DNA polymerase activity
GK046_RS12965	COG0814	amino acid
GK046_RS12980	COG2091	lysine biosynthetic process via aminoadipic acid
GK046_RS12985	COG0431	NADPH-dependent FMN reductase
GK046_RS12990	COG2252	PERMEase
GK046_RS12995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GK046_RS13005	COG3196	Protein conserved in bacteria
GK046_RS13010	COG0363	glucosamine-6-phosphate deaminase activity
GK046_RS13015	COG2382	esterase
GK046_RS13025	COG2723	6-phospho-beta-galactosidase activity
GK046_RS13030	COG2190	(PTS) system
GK046_RS13030	COG1263	PTS System
GK046_RS13030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS13035	COG3711	transcriptional antiterminator
GK046_RS13040	COG0704	Plays a role in the regulation of phosphate uptake
GK046_RS13045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GK046_RS13050	COG0581	inorganic phosphate transmembrane transporter activity
GK046_RS13055	COG0573	inorganic phosphate transmembrane transporter activity
GK046_RS13060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GK046_RS13070	COG3188	usher protein
GK046_RS13080	COG3539	Fimbrial protein
GK046_RS13085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GK046_RS13135	COG3312	ion transport
GK046_RS13150	COG0716	FMN binding
GK046_RS13155	COG1522	sequence-specific DNA binding
GK046_RS13185	COG1129	ABC transporter
GK046_RS13190	COG1172	Belongs to the binding-protein-dependent transport system permease family
GK046_RS13195	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS13200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GK046_RS13205	COG1609	Transcriptional regulator
GK046_RS13210	COG0477	Major facilitator Superfamily
GK046_RS13215	COG2186	Transcriptional regulator
GK046_RS13255	COG3085	chromosome segregation
GK046_RS13260	COG0606	chelatase, subunit chli
GK046_RS13280	COG3978	acetolactate synthase activity
GK046_RS13285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GK046_RS13295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GK046_RS13300	COG0583	DNA-binding transcription factor activity
GK046_RS13310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GK046_RS13315	COG3692	DNA binding
GK046_RS13320	COG0210	DNA helicase
GK046_RS13335	COG3118	belongs to the thioredoxin family
GK046_RS13345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GK046_RS13350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GK046_RS13355	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GK046_RS13360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GK046_RS13365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GK046_RS13370	COG1088	dTDP-glucose 4,6-dehydratase activity
GK046_RS13375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GK046_RS13380	COG0456	acetyltransferase
GK046_RS13385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GK046_RS13390	COG2244	polysaccharide biosynthetic process
GK046_RS13410	COG1113	amino acid transport
GK046_RS13435	COG0641	radical SAM
GK046_RS13440	COG3071	HemY protein
GK046_RS13445	COG2959	enzyme of heme biosynthesis
GK046_RS13450	COG1587	Uroporphyrinogen-III synthase
GK046_RS13460	COG3072	Adenylate cyclase
GK046_RS13470	COG5567	small periplasmic lipoprotein
GK046_RS13480	COG3159	Protein conserved in bacteria
GK046_RS13490	COG1011	Hydrolase
GK046_RS13495	COG0210	DNA helicase
GK046_RS13500	COG3698	Phosphodiester glycosidase
GK046_RS13505	COG0598	Magnesium transport protein CorA
GK046_RS13530	COG2962	Rard protein
GK046_RS13535	COG2050	protein possibly involved in aromatic compounds catabolism
GK046_RS13540	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
GK046_RS13545	COG0514	ATP-dependent DNA helicase (RecQ)
GK046_RS13550	COG1280	lysine exporter protein (LysE YggA)
GK046_RS13555	COG1280	lysine exporter protein (LysE YggA)
GK046_RS13560	COG2267	carboxylic ester hydrolase activity
GK046_RS13565	COG0561	phosphatase activity
GK046_RS13570	COG0697	spore germination
GK046_RS13575	COG0583	DNA-binding transcription factor activity
GK046_RS13585	COG0412	Dienelactone hydrolase
GK046_RS13590	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GK046_RS13595	COG1322	Protein conserved in bacteria
GK046_RS13605	COG3165	ubiquinone biosynthetic process from chorismate
GK046_RS13615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GK046_RS13620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GK046_RS13625	COG0805	protein transport
GK046_RS13635	COG0250	Participates in transcription elongation, termination and antitermination
GK046_RS13640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GK046_RS13645	COG0543	2 iron, 2 sulfur cluster binding
GK046_RS13665	COG1739	Uncharacterized protein family UPF0029
GK046_RS13670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GK046_RS13675	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GK046_RS13705	COG1763	Mo-molybdopterin cofactor biosynthetic process
GK046_RS13710	COG0746	molybdenum cofactor guanylyltransferase activity
GK046_RS13715	COG3084	Protein conserved in bacteria
GK046_RS13720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GK046_RS13725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GK046_RS13730	COG5339	Protein conserved in bacteria
GK046_RS13735	COG0204	Acyl-transferase
GK046_RS13745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GK046_RS13745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GK046_RS13760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GK046_RS13770	COG2204	response regulator
GK046_RS13775	COG3852	Histidine kinase
GK046_RS13780	COG0174	glutamine synthetase
GK046_RS13785	COG1217	gtp-binding protein TYPA
GK046_RS13790	COG2188	Transcriptional regulator
GK046_RS13795	COG1082	Xylose isomerase domain protein TIM barrel
GK046_RS13800	COG2271	Major facilitator Superfamily
GK046_RS13805	COG1349	DNA-binding transcription factor activity
GK046_RS13810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GK046_RS13815	COG2084	Dehydrogenase
GK046_RS13820	COG3684	Belongs to the aldolase LacD family
GK046_RS13825	COG1063	alcohol dehydrogenase
GK046_RS13835	COG0477	Major facilitator Superfamily
GK046_RS13845	COG1011	Hydrolase
GK046_RS13860	COG0456	acetyltransferase
GK046_RS13870	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GK046_RS13880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GK046_RS13885	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GK046_RS13890	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS13900	COG2864	formate dehydrogenase
GK046_RS13905	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS13925	COG3711	transcriptional antiterminator
GK046_RS13925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS13930	COG1363	Peptidase, m42
GK046_RS13935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS13935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS13940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS13980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GK046_RS13990	COG2258	MOSC domain
GK046_RS13995	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS14000	COG2205	protein histidine kinase activity
GK046_RS14005	COG0745	RESPONSE REGULATOR receiver
GK046_RS14010	COG3678	ATP-independent chaperone mediated protein folding
GK046_RS14025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GK046_RS14045	COG3152	Membrane
GK046_RS14050	COG3691	Protein conserved in bacteria
GK046_RS14055	COG0589	response to stress
GK046_RS14065	COG1494	fructose-1,6-bisphosphatase
GK046_RS14075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GK046_RS14090	COG1575	Belongs to the MenA family. Type 1 subfamily
GK046_RS14105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GK046_RS14110	COG1609	Transcriptional regulator
GK046_RS14115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GK046_RS14125	COG3209	COG3209 Rhs family protein
GK046_RS14135	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GK046_RS14145	COG0626	cystathionine gamma-synthase activity
GK046_RS14150	COG0527	aspartate kinase activity
GK046_RS14150	COG0460	homoserine dehydrogenase
GK046_RS14155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GK046_RS14165	COG0697	spore germination
GK046_RS14170	COG3738	Protein conserved in bacteria
GK046_RS14175	COG0371	Dehydrogenase
GK046_RS14180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GK046_RS14185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS14185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS14185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GK046_RS14190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS14195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS14200	COG1882	Formate acetyltransferase
GK046_RS14205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GK046_RS14210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS14215	COG2207	Transcriptional regulator
GK046_RS14220	COG2194	sulfuric ester hydrolase activity
GK046_RS14235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GK046_RS14250	COG0583	DNA-binding transcription factor activity
GK046_RS14260	COG1309	transcriptional regulator
GK046_RS14310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GK046_RS14310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GK046_RS14345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GK046_RS14350	COG0250	Participates in transcription elongation, termination and antitermination
GK046_RS14390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GK046_RS14400	COG2104	thiamine diphosphate biosynthetic process
GK046_RS14405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GK046_RS14440	COG3068	Protein conserved in bacteria
GK046_RS14455	COG3678	ATP-independent chaperone mediated protein folding
GK046_RS14460	COG4191	Histidine kinase
GK046_RS14465	COG2204	response regulator
GK046_RS14470	COG0151	Belongs to the GarS family
GK046_RS14500	COG0456	acetyltransferase
GK046_RS14510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GK046_RS14515	COG2224	Isocitrate lyase
GK046_RS14530	COG1414	Transcriptional regulator
GK046_RS14535	COG1410	methionine synthase
GK046_RS14535	COG0646	methionine synthase
GK046_RS14540	COG1283	sodium-dependent phosphate transmembrane transporter activity
GK046_RS14550	COG1187	pseudouridine synthase activity
GK046_RS14565	COG3541	Predicted nucleotidyltransferase
GK046_RS14570	COG0542	response to heat
GK046_RS14575	COG0527	aspartate kinase activity
GK046_RS14600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GK046_RS14615	COG0477	Major facilitator Superfamily
GK046_RS14615	COG2814	Major facilitator Superfamily
GK046_RS14620	COG3833	ABC-type maltose transport systems, permease component
GK046_RS14625	COG1175	transmembrane transport
GK046_RS14630	COG2182	Extracellular solute-binding protein
GK046_RS14635	COG3842	ATPase activity
GK046_RS14675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GK046_RS14685	COG0534	Mate efflux family protein
GK046_RS14690	COG3237	CsbD-like
GK046_RS14695	COG0735	belongs to the Fur family
GK046_RS14710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GK046_RS14720	COG0604	alcohol dehydrogenase
GK046_RS14725	COG0305	Participates in initiation and elongation during chromosome replication
GK046_RS14730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GK046_RS14735	COG1448	Aminotransferase
GK046_RS14750	COG3700	Belongs to the class B bacterial acid phosphatase family
GK046_RS14755	COG0432	Pfam Uncharacterised protein family UPF0047
GK046_RS14760	COG2315	Protein conserved in bacteria
GK046_RS14765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GK046_RS14770	COG0629	single-stranded DNA binding
GK046_RS14780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GK046_RS14785	COG2207	Transcriptional regulator
GK046_RS14790	COG0789	Transcriptional regulator
GK046_RS14795	COG2252	PERMEase
GK046_RS14800	COG0025	NhaP-type Na H and K H
GK046_RS14805	COG1357	PFAM Pentapeptide repeats (8 copies)
GK046_RS14815	COG3162	membrane
GK046_RS14820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GK046_RS14830	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GK046_RS14835	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS14840	COG3301	Polysulphide reductase, NrfD
GK046_RS14845	COG1138	Cytochrome C-type biogenesis protein
GK046_RS14850	COG3088	subunit of a heme lyase
GK046_RS14855	COG4235	cytochrome complex assembly
GK046_RS14860	COG1301	dicarboxylic acid transport
GK046_RS14865	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GK046_RS14880	COG1289	transmembrane transporter activity
GK046_RS14885	COG1566	PFAM secretion protein HlyD family protein
GK046_RS14895	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GK046_RS14900	COG0698	ribose 5-phosphate isomerase
GK046_RS14910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GK046_RS14915	COG0456	acetyltransferase
GK046_RS14920	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GK046_RS14925	COG3454	Phosphonate metabolism
GK046_RS14930	COG4778	phosphonate C-P lyase system protein PhnL
GK046_RS14935	COG4107	phosphonate C-P lyase system protein PhnK
GK046_RS14940	COG3627	carbon phosphorus lyase activity
GK046_RS14945	COG3626	phosphonate metabolism
GK046_RS14950	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GK046_RS14955	COG3624	Phosphonate C-P lyase system protein PhnG
GK046_RS14960	COG2188	Transcriptional regulator
GK046_RS14965	COG3639	organic phosphonate transmembrane transporter activity
GK046_RS14970	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GK046_RS14980	COG2764	glyoxalase bleomycin resistance protein dioxygenase
GK046_RS14985	COG2824	Alkylphosphonate utilization operon protein PhnA
GK046_RS15000	COG0477	Major facilitator Superfamily
GK046_RS15010	COG0642	Histidine kinase
GK046_RS15015	COG0745	RESPONSE REGULATOR receiver
GK046_RS15020	COG2194	sulfuric ester hydrolase activity
GK046_RS15025	COG0531	amino acid
GK046_RS15030	COG2207	Transcriptional regulator
GK046_RS15035	COG1982	Orn Lys Arg decarboxylase major
GK046_RS15040	COG2169	Transcriptional regulator
GK046_RS15045	COG1486	melibiose metabolic process
GK046_RS15050	COG2211	Major facilitator Superfamily
GK046_RS15055	COG3647	Membrane
GK046_RS15060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GK046_RS15060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GK046_RS15065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GK046_RS15070	COG4565	transcriptional regulatory protein
GK046_RS15075	COG3290	protein histidine kinase activity
GK046_RS15080	COG3592	Divergent 4Fe-4S mono-cluster
GK046_RS15085	COG2388	GCN5-related N-acetyl-transferase
GK046_RS15100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GK046_RS15105	COG3104	oligopeptide transport
GK046_RS15110	COG1982	Orn Lys Arg decarboxylase major
GK046_RS15115	COG0531	amino acid
GK046_RS15120	COG3710	Transcriptional regulator
GK046_RS15130	COG1309	transcriptional regulator
GK046_RS15145	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GK046_RS15150	COG1027	Aspartate ammonia-lyase
GK046_RS15155	COG3030	protein affecting phage T7 exclusion by the F plasmid
GK046_RS15160	COG0531	amino acid
GK046_RS15180	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS15190	COG1509	lysine 2,3-aminomutase activity
GK046_RS15200	COG5510	response to toxic substance
GK046_RS15205	COG5510	response to toxic substance
GK046_RS15210	COG2076	Multidrug Resistance protein
GK046_RS15215	COG3040	lipid binding
GK046_RS15220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GK046_RS15235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GK046_RS15240	COG1053	succinate dehydrogenase
GK046_RS15250	COG0531	amino acid
GK046_RS15255	COG1511	domain protein
GK046_RS15255	COG3264	Mechanosensitive ion channel
GK046_RS15300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GK046_RS15300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GK046_RS15305	COG0802	atpase or kinase
GK046_RS15310	COG0860	N-Acetylmuramoyl-L-alanine amidase
GK046_RS15330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GK046_RS15335	COG0330	HflC and HflK could
GK046_RS15340	COG0330	HflC and HflK could
GK046_RS15345	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GK046_RS15360	COG0557	exoribonuclease II activity
GK046_RS15365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GK046_RS15370	COG3789	protein conserved in bacteria
GK046_RS15375	COG1842	Phage shock protein A
GK046_RS15385	COG3766	membrane
GK046_RS15390	COG5463	Belongs to the UPF0441 family
GK046_RS15395	COG0754	glutathionylspermidine amidase activity
GK046_RS15400	COG1960	acyl-CoA dehydrogenase activity
GK046_RS15410	COG3650	response to hydrogen peroxide
GK046_RS15415	COG1073	alpha beta
GK046_RS15430	COG3037	sugar-specific permease SgaT UlaA
GK046_RS15460	COG3477	response to acidic pH
GK046_RS15480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GK046_RS15505	COG0675	Transposase, IS605 OrfB family
GK046_RS15515	COG3061	Opacity-associated protein A
GK046_RS15520	COG0545	Peptidyl-prolyl cis-trans isomerase
GK046_RS15525	COG1113	amino acid transport
GK046_RS15535	COG0697	spore germination
GK046_RS15540	COG0702	epimerase
GK046_RS15545	COG1733	regulation of RNA biosynthetic process
GK046_RS15550	COG0737	Belongs to the 5'-nucleotidase family
GK046_RS15555	COG1218	3'(2'),5'-bisphosphate nucleotidase
GK046_RS15560	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GK046_RS15570	COG1253	flavin adenine dinucleotide binding
GK046_RS15580	COG0729	surface antigen
GK046_RS15585	COG2911	Protein conserved in bacteria
GK046_RS15590	COG2105	PFAM AIG2 family protein
GK046_RS15595	COG2336	PFAM SpoVT AbrB
GK046_RS15600	COG2337	Toxic component of a toxin-antitoxin (TA) module
GK046_RS15605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GK046_RS15610	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS15615	COG1129	ABC transporter
GK046_RS15620	COG1172	Belongs to the binding-protein-dependent transport system permease family
GK046_RS15625	COG1172	Belongs to the binding-protein-dependent transport system permease family
GK046_RS15635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GK046_RS15645	COG0312	modulator of DNA gyrase
GK046_RS15650	COG3783	Cytochrome b(562)
GK046_RS15655	COG0602	queuosine metabolic process
GK046_RS15660	COG1328	CTP reductase activity
GK046_RS15665	COG0366	Alpha amylase catalytic
GK046_RS15670	COG1263	PTS System
GK046_RS15670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS15675	COG1609	Transcriptional regulator
GK046_RS15685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GK046_RS15690	COG0251	oxidation-reduction process
GK046_RS15710	COG0251	oxidation-reduction process
GK046_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS15720	COG1309	transcriptional regulator
GK046_RS15725	COG2731	YhcH YjgK YiaL family protein
GK046_RS15745	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GK046_RS15750	COG0456	acetyltransferase
GK046_RS15755	COG4269	membrane
GK046_RS15760	COG0525	valine-tRNA ligase activity
GK046_RS15765	COG2927	DNA polymerase III (CHI subunit)
GK046_RS15775	COG0795	lipopolysaccharide-transporting ATPase activity
GK046_RS15780	COG0795	lipopolysaccharide-transporting ATPase activity
GK046_RS15785	COG0433	COG0433 Predicted ATPase
GK046_RS15790	COG1064	alcohol dehydrogenase
GK046_RS15800	COG0582	viral genome integration into host DNA
GK046_RS15830	COG2003	Belongs to the UPF0758 family
GK046_RS16125	COG2003	Belongs to the UPF0758 family
GK046_RS16160	COG0582	viral genome integration into host DNA
GK046_RS16245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GK046_RS16250	COG0582	viral genome integration into host DNA
GK046_RS16255	COG4974	Belongs to the 'phage' integrase family
GK046_RS16265	COG3539	Fimbrial protein
GK046_RS16270	COG3121	Chaperone
GK046_RS16275	COG3188	usher protein
GK046_RS16280	COG3539	Fimbrial protein
GK046_RS16285	COG3539	Fimbrial protein
GK046_RS16290	COG3539	Fimbrial protein
GK046_RS16295	COG2610	gluconate transmembrane transporter activity
GK046_RS16305	COG0246	Mannitol dehydrogenase
GK046_RS16310	COG2186	Transcriptional regulator
GK046_RS16330	COG0583	DNA-binding transcription factor activity
GK046_RS16335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GK046_RS16340	COG0700	Nucleoside recognition
GK046_RS16345	COG3366	ferrous iron transmembrane transporter activity
GK046_RS16355	COG0477	Major facilitator Superfamily
GK046_RS16370	COG1924	4 iron, 4 sulfur cluster binding
GK046_RS16375	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GK046_RS16380	COG2733	membrane
GK046_RS16385	COG2814	Major facilitator Superfamily
GK046_RS16395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GK046_RS16400	COG5457	Domain of unknown function (DUF1127)
GK046_RS16410	COG0523	cobalamin synthesis protein
GK046_RS16415	COG2879	small protein
GK046_RS16420	COG1966	Carbon starvation protein
GK046_RS16425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GK046_RS16430	COG2368	4-hydroxyphenylacetate
GK046_RS16450	COG3971	2-oxopent-4-enoate hydratase activity
GK046_RS16460	COG3384	dioxygenase
GK046_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS16470	COG0179	Fumarylacetoacetate (FAA) hydrolase
GK046_RS16475	COG1846	Transcriptional regulator
GK046_RS16480	COG0840	transmembrane signaling receptor activity
GK046_RS16485	COG2271	Major facilitator Superfamily
GK046_RS16490	COG1802	Transcriptional regulator
GK046_RS16495	COG1063	alcohol dehydrogenase
GK046_RS16510	COG1484	DNA-dependent DNA replication
GK046_RS16525	COG2966	Psort location CytoplasmicMembrane, score
GK046_RS16530	COG2197	response regulator
GK046_RS16535	COG2197	response regulator
GK046_RS16540	COG4114	ferric iron reductase
GK046_RS16570	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
GK046_RS16575	COG0456	acetyltransferase
GK046_RS16580	COG1011	Hydrolase
GK046_RS16590	COG2823	Periplasmic or secreted lipoprotein
GK046_RS16600	COG4667	esterase of the alpha-beta hydrolase superfamily
GK046_RS16605	COG0084	hydrolase, TatD family'
GK046_RS16610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GK046_RS16615	COG1328	CTP reductase activity
GK046_RS16645	COG3726	membrane protein affecting hemolysin expression
GK046_RS16650	COG0560	Phosphoserine phosphatase
GK046_RS16655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GK046_RS16660	COG3172	ATPase kinase involved in NAD metabolism
GK046_RS16660	COG1056	cytidyltransferase-related domain
GK046_RS16665	COG0488	(ABC) transporter
GK046_RS16670	COG0741	lytic transglycosylase activity
GK046_RS16690	COG3708	Transcriptional regulator
GK046_RS16690	COG2207	Transcriptional regulator
GK046_RS16695	COG3045	CreA protein
GK046_RS16700	COG0745	RESPONSE REGULATOR receiver
GK046_RS16705	COG2205	protein histidine kinase activity
GK046_RS16710	COG4452	Inner membrane protein CreD
GK046_RS16715	COG0745	RESPONSE REGULATOR receiver
GK046_RS16725	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GK046_RS16735	COG0460	homoserine dehydrogenase
GK046_RS16735	COG0527	aspartate kinase activity
GK046_RS16745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GK046_RS16755	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS16765	COG1115	amino acid carrier protein
GK046_RS16775	COG0521	Mo-molybdopterin cofactor biosynthetic process
GK046_RS16780	COG1584	GPR1 FUN34 yaaH family protein
GK046_RS16785	COG4735	regulation of single-species biofilm formation
GK046_RS16805	COG3385	transposase activity
GK046_RS16820	COG0583	DNA-binding transcription factor activity
GK046_RS16850	COG0196	riboflavin kinase activity
GK046_RS16865	COG1047	Peptidyl-prolyl cis-trans
GK046_RS16885	COG0505	Belongs to the CarA family
GK046_RS16890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GK046_RS16940	COG0644	oxidoreductase
GK046_RS16945	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GK046_RS16950	COG2271	Major facilitator Superfamily
GK046_RS16965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GK046_RS17005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GK046_RS17010	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GK046_RS17015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GK046_RS17020	COG0564	pseudouridine synthase activity
GK046_RS17030	COG0417	DNA replication proofreading
GK046_RS17035	COG0235	Class ii aldolase
GK046_RS17050	COG4977	sequence-specific DNA binding
GK046_RS17055	COG0586	Pfam SNARE associated Golgi protein
GK046_RS17065	COG1178	ABC-type Fe3 transport system permease component
GK046_RS17070	COG4143	(ABC) transporter
GK046_RS17085	COG2814	Major facilitator Superfamily
GK046_RS17100	COG0473	3-isopropylmalate dehydrogenase activity
GK046_RS17115	COG0583	DNA-binding transcription factor activity
GK046_RS17120	COG0028	Belongs to the TPP enzyme family
GK046_RS17125	COG0440	acetolactate synthase activity
GK046_RS17135	COG1609	Transcriptional regulator
GK046_RS17150	COG3116	cell division
GK046_RS17155	COG0768	penicillin binding
GK046_RS17160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GK046_RS17165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GK046_RS17180	COG0772	Belongs to the SEDS family
GK046_RS17195	COG1181	Belongs to the D-alanine--D-alanine ligase family
GK046_RS17200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GK046_RS17205	COG0849	cell division
GK046_RS17210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GK046_RS17230	COG0494	nUDIX hydrolase
GK046_RS17255	COG1459	type II secretion system
GK046_RS17260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GK046_RS17265	COG4969	Belongs to the N-Me-Phe pilin family
GK046_RS17270	COG0157	Belongs to the NadC ModD family
GK046_RS17275	COG3023	N-Acetylmuramoyl-L-alanine amidase
GK046_RS17280	COG3725	Membrane protein required for beta-lactamase induction
GK046_RS17285	COG1113	amino acid transport
GK046_RS17290	COG2186	Transcriptional regulator
GK046_RS17295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GK046_RS17300	COG0508	dehydrogenase complex catalyzes the overall conversion of
GK046_RS17305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GK046_RS17310	COG3064	Membrane
GK046_RS17315	COG1049	propionate catabolic process, 2-methylcitrate cycle
GK046_RS17340	COG2132	Multicopper oxidase
GK046_RS17345	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS17350	COG4993	Dehydrogenase
GK046_RS17355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GK046_RS17360	COG0288	reversible hydration of carbon dioxide
GK046_RS17365	COG1131	(ABC) transporter
GK046_RS17370	COG0842	Transport permease protein
GK046_RS17375	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS17380	COG0726	polysaccharide deacetylase
GK046_RS17390	COG5464	transposase or invertase
GK046_RS17405	COG3539	Fimbrial protein
GK046_RS17410	COG3539	Fimbrial protein
GK046_RS17415	COG3539	Fimbrial protein
GK046_RS17420	COG3539	Fimbrial protein
GK046_RS17425	COG3188	usher protein
GK046_RS17430	COG3121	Chaperone
GK046_RS17435	COG3539	Fimbrial protein
GK046_RS17440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GK046_RS17445	COG0617	tRNA 3'-terminal CCA addition
GK046_RS17455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GK046_RS17465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GK046_RS17470	COG1643	Atp-dependent helicase
GK046_RS17475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GK046_RS17480	COG4774	siderophore transport
GK046_RS17485	COG1120	ATPase activity
GK046_RS17490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GK046_RS17495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GK046_RS17520	COG2860	membrane
GK046_RS17525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GK046_RS17540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GK046_RS17545	COG3835	regulator
GK046_RS17565	COG0024	Methionine aminopeptidase
GK046_RS17590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GK046_RS17595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GK046_RS17600	COG0575	Belongs to the CDS family
GK046_RS17605	COG0750	zinc metalloprotease
GK046_RS17615	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GK046_RS17620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GK046_RS17645	COG0587	DNA-directed DNA polymerase activity
GK046_RS17655	COG1982	Orn Lys Arg decarboxylase major
GK046_RS17660	COG0346	lactoylglutathione lyase activity
GK046_RS17670	COG4568	rho-dependent transcription termination
GK046_RS17680	COG4681	YaeQ
GK046_RS17685	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GK046_RS17690	COG3015	lipoprotein NlpE involved in copper resistance
GK046_RS17695	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS17700	COG0791	NLP P60 protein
GK046_RS17710	COG1720	tRNA m6t6A37 methyltransferase activity
GK046_RS17720	COG1464	Belongs to the NlpA lipoprotein family
GK046_RS17725	COG2011	ABC-type metal ion transport system permease component
GK046_RS17730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GK046_RS17735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GK046_RS17770	COG0656	L-ascorbic acid biosynthetic process
GK046_RS17775	COG0583	DNA-binding transcription factor activity
GK046_RS17785	COG2226	methyltransferase
GK046_RS17790	COG1388	LysM domain
GK046_RS17790	COG0741	lytic transglycosylase activity
GK046_RS17800	COG2226	methyltransferase
GK046_RS17810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GK046_RS17830	COG4104	PAAR repeat-containing protein
GK046_RS17835	COG3157	Type VI secretion system effector, Hcp
GK046_RS17935	COG3209	COG3209 Rhs family protein
GK046_RS17950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GK046_RS17960	COG1960	acyl-CoA dehydrogenase activity
GK046_RS17970	COG0121	glutamine amidotransferase
GK046_RS17975	COG3034	peptidoglycan biosynthetic process
GK046_RS17980	COG3041	Addiction module toxin RelE StbE family
GK046_RS17985	COG3077	Addiction module antitoxin, RelB DinJ family
GK046_RS17990	COG0791	NLP P60 protein
GK046_RS18020	COG0454	-acetyltransferase
GK046_RS18025	COG1690	Belongs to the RtcB family
GK046_RS18030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GK046_RS18035	COG2195	Cleaves the N-terminal amino acid of tripeptides
GK046_RS18055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GK046_RS18075	COG0583	DNA-binding transcription factor activity
GK046_RS18080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GK046_RS18085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GK046_RS18090	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GK046_RS18095	COG2080	2 iron, 2 sulfur cluster binding
GK046_RS18100	COG3477	response to acidic pH
GK046_RS18105	COG0727	PFAM Uncharacterised protein family (UPF0153)
GK046_RS18110	COG3121	Chaperone
GK046_RS18120	COG3188	usher protein
GK046_RS18165	COG1388	LysM domain
GK046_RS18170	COG4932	domain protein
GK046_RS18170	COG2373	Large extracellular alpha-helical protein
GK046_RS18170	COG1388	LysM domain
GK046_RS18175	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS18185	COG2207	Transcriptional regulator
GK046_RS18185	COG3708	Transcriptional regulator
GK046_RS18190	COG0656	L-ascorbic acid biosynthetic process
GK046_RS18195	COG3059	membrane
GK046_RS18205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GK046_RS18210	COG2207	Transcriptional regulator
GK046_RS18215	COG0247	lactate metabolic process
GK046_RS18220	COG1139	Iron-sulfur cluster binding protein
GK046_RS18225	COG1556	Lactate utilization protein
GK046_RS18250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GK046_RS18260	COG2771	luxR family
GK046_RS18260	COG2200	EAL domain
GK046_RS18265	COG0583	DNA-binding transcription factor activity
GK046_RS18275	COG0666	response to abiotic stimulus
GK046_RS18285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GK046_RS18290	COG1304	FMN binding
GK046_RS18295	COG0549	Belongs to the carbamate kinase family
GK046_RS18300	COG0402	S-adenosylhomocysteine deaminase activity
GK046_RS18310	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS18315	COG1129	ABC transporter
GK046_RS18320	COG1172	Belongs to the binding-protein-dependent transport system permease family
GK046_RS18330	COG1064	alcohol dehydrogenase
GK046_RS18345	COG1280	lysine exporter protein (LysE YggA)
GK046_RS18355	COG3829	transcription factor binding
GK046_RS18360	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GK046_RS18365	COG0372	Belongs to the citrate synthase family
GK046_RS18370	COG2079	MmgE PrpD family protein
GK046_RS18375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GK046_RS18380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GK046_RS18385	COG0402	S-adenosylhomocysteine deaminase activity
GK046_RS18390	COG0583	DNA-binding transcription factor activity
GK046_RS18395	COG0288	reversible hydration of carbon dioxide
GK046_RS18405	COG2807	transmembrane transport
GK046_RS18410	COG0110	maltose O-acetyltransferase activity
GK046_RS18415	COG2223	nitrite transmembrane transporter activity
GK046_RS18420	COG3250	beta-galactosidase activity
GK046_RS18425	COG1609	Transcriptional regulator
GK046_RS18430	COG1414	Transcriptional regulator
GK046_RS18465	COG2814	Major facilitator Superfamily
GK046_RS18470	COG3122	Protein conserved in bacteria
GK046_RS18500	COG1215	transferase activity, transferring glycosyl groups
GK046_RS18505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GK046_RS18510	COG4521	taurine ABC transporter
GK046_RS18520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GK046_RS18525	COG2175	clavaminate synthase activity
GK046_RS18530	COG0113	porphobilinogen synthase activity
GK046_RS18535	COG3468	outer membrane autotransporter barrel domain protein
GK046_RS18540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GK046_RS18545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GK046_RS18550	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GK046_RS18570	COG1181	Belongs to the D-alanine--D-alanine ligase family
GK046_RS18580	COG1785	Belongs to the alkaline phosphatase family
GK046_RS18590	COG3706	GGDEF domain
GK046_RS18595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GK046_RS18615	COG4126	flavin adenine dinucleotide binding
GK046_RS18640	COG1940	carbohydrate kinase activity
GK046_RS18645	COG2814	Major facilitator Superfamily
GK046_RS18650	COG0419	ATPase involved in DNA repair
GK046_RS18655	COG0420	3'-5' exonuclease activity
GK046_RS18660	COG0745	RESPONSE REGULATOR receiver
GK046_RS18665	COG5002	protein histidine kinase activity
GK046_RS18670	COG1114	Component of the transport system for branched-chain amino acids
GK046_RS18675	COG1113	amino acid transport
GK046_RS18680	COG0366	Alpha amylase catalytic
GK046_RS18700	COG1862	Preprotein translocase
GK046_RS18705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GK046_RS18710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GK046_RS18715	COG1403	HNH endonuclease
GK046_RS18720	COG3248	Nucleoside-binding outer membrane protein
GK046_RS18725	COG4238	major outer membrane lipoprotein
GK046_RS18735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GK046_RS18735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GK046_RS18750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GK046_RS18755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GK046_RS18770	COG0142	geranyltranstransferase activity
GK046_RS18785	COG0693	protein deglycase activity
GK046_RS18790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GK046_RS18800	COG2814	Major facilitator Superfamily
GK046_RS18825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GK046_RS18830	COG1845	cytochrome c oxidase, subunit III
GK046_RS18835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GK046_RS18840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GK046_RS18845	COG2223	nitrite transmembrane transporter activity
GK046_RS18850	COG3056	Lipoprotein
GK046_RS18855	COG0271	Belongs to the BolA IbaG family
GK046_RS18875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GK046_RS18880	COG0776	regulation of translation
GK046_RS18885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GK046_RS18890	COG1555	photosystem II stabilization
GK046_RS18895	COG0824	Thioesterase
GK046_RS18905	COG4533	DNA binding
GK046_RS18915	COG1522	sequence-specific DNA binding
GK046_RS18920	COG1132	(ABC) transporter
GK046_RS18925	COG1132	(ABC) transporter
GK046_RS18930	COG0347	Belongs to the P(II) protein family
GK046_RS18935	COG0004	ammonium transporteR
GK046_RS18940	COG1946	Acyl-CoA thioesterase
GK046_RS18945	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GK046_RS18950	COG3695	enzyme binding
GK046_RS18960	COG5507	3-demethylubiquinone-9 3-methyltransferase
GK046_RS18965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GK046_RS18975	COG0110	maltose O-acetyltransferase activity
GK046_RS18990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GK046_RS18995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS19000	COG1309	transcriptional regulator
GK046_RS19005	COG1196	nuclear chromosome segregation
GK046_RS19005	COG3264	Mechanosensitive ion channel
GK046_RS19015	COG3923	Primosomal replication protein n
GK046_RS19020	COG2832	Protein of unknown function (DUF454)
GK046_RS19030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GK046_RS19065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GK046_RS19070	COG4651	solute:proton antiporter activity
GK046_RS19070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GK046_RS19075	COG2223	nitrite transmembrane transporter activity
GK046_RS19080	COG0737	Belongs to the 5'-nucleotidase family
GK046_RS19085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GK046_RS19090	COG3735	TraB family
GK046_RS19095	COG3093	addiction module antidote protein HigA
GK046_RS19100	COG2217	Heavy metal translocating P-type atpase
GK046_RS19105	COG2066	Belongs to the glutaminase family
GK046_RS19110	COG0531	amino acid
GK046_RS19115	COG0789	Transcriptional regulator
GK046_RS19120	COG1585	Membrane protein implicated in regulation of membrane protease activity
GK046_RS19125	COG0330	HflC and HflK could
GK046_RS19130	COG4619	ABC transporter
GK046_RS19135	COG0390	transport system, permease component
GK046_RS19140	COG3118	belongs to the thioredoxin family
GK046_RS19145	COG0300	oxidoreductase activity
GK046_RS19150	COG2755	lipolytic protein G-D-S-L family
GK046_RS19155	COG4181	ATPase activity
GK046_RS19160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GK046_RS19165	COG3209	COG3209 Rhs family protein
GK046_RS19185	COG0583	DNA-binding transcription factor activity
GK046_RS19195	COG1414	Transcriptional regulator
GK046_RS19200	COG3960	tartronate-semialdehyde synthase activity
GK046_RS19205	COG3622	Belongs to the hyi family
GK046_RS19210	COG2084	Dehydrogenase
GK046_RS19215	COG1953	Uracil, thiamine, allantoin
GK046_RS19225	COG2233	PERMEase
GK046_RS19230	COG1929	Belongs to the glycerate kinase type-1 family
GK046_RS19235	COG3257	ureidoglycine aminohydrolase activity
GK046_RS19240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GK046_RS19245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GK046_RS19250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GK046_RS19255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GK046_RS19265	COG0549	Belongs to the carbamate kinase family
GK046_RS19270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GK046_RS19275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GK046_RS19285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GK046_RS19295	COG1988	membrane-bound metal-dependent
GK046_RS19300	COG2501	S4 domain
GK046_RS19310	COG3539	Fimbrial protein
GK046_RS19315	COG3121	Chaperone
GK046_RS19320	COG3188	usher protein
GK046_RS19325	COG3539	Fimbrial protein
GK046_RS19330	COG3539	Fimbrial protein
GK046_RS19335	COG2197	response regulator
GK046_RS19345	COG0582	viral genome integration into host DNA
GK046_RS19530	COG3772	lysozyme
GK046_RS19570	COG1030	water channel activity
GK046_RS19620	COG1196	nuclear chromosome segregation
GK046_RS19655	COG5301	cellulose 1,4-beta-cellobiosidase activity
GK046_RS19660	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GK046_RS19665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GK046_RS19680	COG0500	methyltransferase
GK046_RS19695	COG4571	Outer membrane protease
GK046_RS19700	COG2207	Transcriptional regulator
GK046_RS19710	COG4783	chaperone-mediated protein folding
GK046_RS19715	COG1215	transferase activity, transferring glycosyl groups
GK046_RS19720	COG5433	transposase activity
GK046_RS19735	COG3209	COG3209 Rhs family protein
GK046_RS19735	COG4104	PAAR repeat-containing protein
GK046_RS19745	COG3501	Rhs element vgr protein
GK046_RS19750	COG5002	protein histidine kinase activity
GK046_RS19755	COG0745	RESPONSE REGULATOR receiver
GK046_RS19760	COG1538	Outer membrane efflux protein
GK046_RS19765	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS19770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS19775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GK046_RS19780	COG1113	amino acid transport
GK046_RS19785	COG0668	transmembrane transport
GK046_RS19790	COG0778	Nitroreductase
GK046_RS19795	COG2315	Protein conserved in bacteria
GK046_RS19815	COG3385	transposase activity
GK046_RS19825	COG3385	transposase activity
GK046_RS19830	COG2977	Belongs to the P-Pant transferase superfamily
GK046_RS19835	COG4771	TonB-dependent receptor
GK046_RS19840	COG2382	esterase
GK046_RS19845	COG3251	PFAM MbtH domain protein
GK046_RS19850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GK046_RS19850	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GK046_RS19855	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GK046_RS19860	COG1120	ATPase activity
GK046_RS19865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GK046_RS19870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GK046_RS19880	COG4592	Periplasmic binding protein
GK046_RS19885	COG1169	isochorismate synthase
GK046_RS19890	COG1021	2,3-dihydroxybenzoate-AMP ligase
GK046_RS19895	COG1535	isochorismatase
GK046_RS19895	COG3433	isochorismatase activity
GK046_RS19900	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS19905	COG2050	protein possibly involved in aromatic compounds catabolism
GK046_RS19910	COG1966	Carbon starvation protein
GK046_RS19915	COG2879	small protein
GK046_RS19920	COG0371	Dehydrogenase
GK046_RS19925	COG0436	Aminotransferase
GK046_RS19930	COG1475	DNA binding
GK046_RS19935	COG3969	phosphoadenosine phosphosulfate
GK046_RS19940	COG0583	DNA-binding transcription factor activity
GK046_RS19945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GK046_RS19950	COG0450	alkyl hydroperoxide reductase
GK046_RS19955	COG3634	alkyl hydroperoxide reductase activity
GK046_RS19960	COG0589	response to stress
GK046_RS19965	COG1063	alcohol dehydrogenase
GK046_RS19970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GK046_RS19975	COG3719	Belongs to the RNase T2 family
GK046_RS19980	COG0471	metal ion transport
GK046_RS19995	COG3051	citrate lyase alpha subunit
GK046_RS20000	COG2301	Belongs to the HpcH HpaI aldolase family
GK046_RS20010	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GK046_RS20015	COG3290	protein histidine kinase activity
GK046_RS20020	COG4565	transcriptional regulatory protein
GK046_RS20025	COG3069	C4-dicarboxylate transmembrane transporter activity
GK046_RS20045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GK046_RS20050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GK046_RS20060	COG0583	DNA-binding transcription factor activity
GK046_RS20075	COG1686	Belongs to the peptidase S11 family
GK046_RS20080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GK046_RS20085	COG0772	Belongs to the SEDS family
GK046_RS20090	COG0768	penicillin binding
GK046_RS20100	COG0799	negative regulation of ribosome biogenesis
GK046_RS20105	COG0406	alpha-ribazole phosphatase activity
GK046_RS20115	COG1466	dna polymerase III delta subunit
GK046_RS20130	COG2888	peptidyl-tyrosine sulfation
GK046_RS20135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GK046_RS20145	COG2214	Heat shock protein DnaJ domain protein
GK046_RS20150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GK046_RS20160	COG2214	Heat shock protein DnaJ domain protein
GK046_RS20165	COG0443	Heat shock 70 kDa protein
GK046_RS20175	COG1126	abc transporter atp-binding protein
GK046_RS20180	COG0765	amino acid transport
GK046_RS20185	COG0765	amino acid transport
GK046_RS20190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS20200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GK046_RS20205	COG4535	Mg2 and Co2 transporter CorC
GK046_RS20215	COG1702	phosphate starvation-inducible protein PhoH
GK046_RS20225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GK046_RS20270	COG0367	asparagine synthase
GK046_RS20275	COG0647	UMP catabolic process
GK046_RS20280	COG1846	Transcriptional regulator
GK046_RS20280	COG1940	carbohydrate kinase activity
GK046_RS20285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GK046_RS20295	COG2190	(PTS) system
GK046_RS20295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS20295	COG1263	PTS System
GK046_RS20315	COG0735	belongs to the Fur family
GK046_RS20325	COG0716	FMN binding
GK046_RS20335	COG0596	Alpha beta hydrolase
GK046_RS20340	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GK046_RS20345	COG0033	Phosphoglucomutase
GK046_RS20350	COG0531	amino acid
GK046_RS20355	COG1982	Orn Lys Arg decarboxylase major
GK046_RS20365	COG0745	RESPONSE REGULATOR receiver
GK046_RS20370	COG2205	protein histidine kinase activity
GK046_RS20400	COG3209	COG3209 Rhs family protein
GK046_RS20430	COG3272	Protein of unknown function (DUF1722)
GK046_RS20435	COG0415	Belongs to the DNA photolyase family
GK046_RS20445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GK046_RS20450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GK046_RS20455	COG1984	allophanate hydrolase subunit 2
GK046_RS20470	COG3180	Ammonia monooxygenase
GK046_RS20475	COG3539	Fimbrial protein
GK046_RS20480	COG3121	Chaperone
GK046_RS20485	COG3188	usher protein
GK046_RS20490	COG3539	Fimbrial protein
GK046_RS20495	COG0372	Belongs to the citrate synthase family
GK046_RS20505	COG2009	succinate dehydrogenase
GK046_RS20510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GK046_RS20515	COG1053	succinate dehydrogenase
GK046_RS20520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GK046_RS20525	COG0567	Dehydrogenase, E1 component
GK046_RS20530	COG0508	dehydrogenase complex catalyzes the overall conversion of
GK046_RS20540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GK046_RS20545	COG2188	Transcriptional regulator
GK046_RS20550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS20550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GK046_RS20550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS20555	COG0383	alpha-mannosidase activity
GK046_RS20560	COG1271	oxidase subunit
GK046_RS20565	COG1294	oxidase, subunit
GK046_RS20570	COG4890	Cyd operon protein YbgT
GK046_RS20575	COG3790	cyd operon protein YbgE
GK046_RS20580	COG0824	Thioesterase
GK046_RS20585	COG0811	peptide transport
GK046_RS20590	COG0848	biopolymer transport protein
GK046_RS20595	COG3064	Membrane
GK046_RS20605	COG2885	chlorophyll binding
GK046_RS20610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GK046_RS20660	COG3201	nicotinamide mononucleotide transporter
GK046_RS20665	COG1230	cation diffusion facilitator family transporter
GK046_RS20675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GK046_RS20685	COG2017	converts alpha-aldose to the beta-anomer
GK046_RS20695	COG1085	galactose-1-phosphate uridylyltransferase
GK046_RS20700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GK046_RS20705	COG1119	ATPase activity
GK046_RS20710	COG2005	Transcriptional regulator
GK046_RS20710	COG3585	molybdate ion transport
GK046_RS20720	COG0725	ABC transporter, periplasmic molybdate-binding protein
GK046_RS20725	COG4149	molybdate abc transporter
GK046_RS20735	COG0561	phosphatase activity
GK046_RS20745	COG0583	DNA-binding transcription factor activity
GK046_RS20750	COG2828	Protein conserved in bacteria
GK046_RS20755	COG0471	metal ion transport
GK046_RS20760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GK046_RS20765	COG4677	pectinesterase activity
GK046_RS20770	COG1881	PFAM PEBP family protein
GK046_RS20775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GK046_RS20790	COG2226	methyltransferase
GK046_RS20795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GK046_RS20805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GK046_RS20815	COG0521	Mo-molybdopterin cofactor biosynthetic process
GK046_RS20825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GK046_RS20830	COG0314	molybdopterin synthase activity
GK046_RS20835	COG0670	Belongs to the BI1 family
GK046_RS20840	COG0670	Belongs to the BI1 family
GK046_RS20845	COG0392	lysyltransferase activity
GK046_RS20850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GK046_RS20855	COG3568	Endonuclease Exonuclease Phosphatase
GK046_RS20865	COG0842	Transport permease protein
GK046_RS20870	COG0842	Transport permease protein
GK046_RS20875	COG1131	(ABC) transporter
GK046_RS20885	COG1309	transcriptional regulator
GK046_RS20890	COG0513	Belongs to the DEAD box helicase family
GK046_RS20895	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GK046_RS20900	COG1199	ATP-dependent helicase activity
GK046_RS20905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GK046_RS20910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GK046_RS20920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GK046_RS20930	COG4774	siderophore transport
GK046_RS20945	COG0668	transmembrane transport
GK046_RS20950	COG1126	abc transporter atp-binding protein
GK046_RS20955	COG0765	amino acid transport
GK046_RS20960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS20970	COG5006	permease, DMT superfamily
GK046_RS20980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GK046_RS20985	COG2194	sulfuric ester hydrolase activity
GK046_RS20995	COG1321	iron dependent repressor
GK046_RS21000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GK046_RS21005	COG1376	ErfK ybiS ycfS ynhG family protein
GK046_RS21010	COG0488	(ABC) transporter
GK046_RS21015	COG3547	Transposase (IS116 IS110 IS902 family)
GK046_RS21025	COG0561	phosphatase activity
GK046_RS21030	COG1882	Formate acetyltransferase
GK046_RS21035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GK046_RS21040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GK046_RS21045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GK046_RS21050	COG0303	'Molybdopterin
GK046_RS21055	COG1446	asparaginase
GK046_RS21080	COG2200	EAL domain
GK046_RS21085	COG2199	diguanylate cyclase activity
GK046_RS21100	COG2133	pyrroloquinoline quinone binding
GK046_RS21105	COG0625	glutathione transferase activity
GK046_RS21110	COG1686	Belongs to the peptidase S11 family
GK046_RS21115	COG1349	DNA-binding transcription factor activity
GK046_RS21120	COG0671	phosphoesterase, PA-phosphatase related
GK046_RS21125	COG2814	Major facilitator Superfamily
GK046_RS21135	COG0561	phosphatase activity
GK046_RS21140	COG0738	Major facilitator superfamily
GK046_RS21145	COG3226	Transcriptional regulator
GK046_RS21155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GK046_RS21200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GK046_RS21240	COG4695	Portal protein
GK046_RS21335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GK046_RS21350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GK046_RS21405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GK046_RS21415	COG0778	Nitroreductase
GK046_RS21430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GK046_RS21435	COG3842	ATPase activity
GK046_RS21440	COG1176	ABC-type spermidine putrescine transport system, permease component I
GK046_RS21445	COG1177	transmembrane transport
GK046_RS21460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS21465	COG4160	amino acid transport
GK046_RS21470	COG4215	(ABC) transporter
GK046_RS21475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GK046_RS21480	COG1126	abc transporter atp-binding protein
GK046_RS21495	COG3023	N-Acetylmuramoyl-L-alanine amidase
GK046_RS21500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GK046_RS21505	COG0702	epimerase
GK046_RS21510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GK046_RS21515	COG0028	Belongs to the TPP enzyme family
GK046_RS21520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GK046_RS21530	COG2431	L-lysine efflux transmembrane transporter activity
GK046_RS21540	COG3593	DNA synthesis involved in DNA repair
GK046_RS21545	COG2990	Protein conserved in bacteria
GK046_RS21550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GK046_RS21555	COG0577	efflux transmembrane transporter activity
GK046_RS21555	COG1136	(ABC) transporter
GK046_RS21560	COG1278	Cold shock
GK046_RS21570	COG0542	response to heat
GK046_RS21590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GK046_RS21595	COG4988	ABC transporter
GK046_RS21600	COG0492	ferredoxin-NADP+ reductase activity
GK046_RS21605	COG1522	sequence-specific DNA binding
GK046_RS21620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GK046_RS21630	COG0243	molybdopterin cofactor binding
GK046_RS21635	COG0437	4 iron, 4 sulfur cluster binding
GK046_RS21640	COG3302	dmso reductase anchor subunit
GK046_RS21645	COG1335	isochorismatase
GK046_RS21655	COG0531	amino acid
GK046_RS21660	COG0583	DNA-binding transcription factor activity
GK046_RS21665	COG2249	NAD(P)H dehydrogenase (quinone) activity
GK046_RS21670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GK046_RS21675	COG1882	Formate acetyltransferase
GK046_RS21680	COG2116	formate transmembrane transporter activity
GK046_RS21685	COG1944	ATP diphosphatase activity
GK046_RS21690	COG2323	membrane
GK046_RS21705	COG0501	Belongs to the peptidase M48B family
GK046_RS21715	COG0539	negative regulation of cytoplasmic translation
GK046_RS21725	COG2333	competence protein COMEC
GK046_RS21725	COG0658	competence protein
GK046_RS21730	COG1132	(ABC) transporter
GK046_RS21740	COG3214	Protein conserved in bacteria
GK046_RS21755	COG3173	Aminoglycoside phosphotransferase
GK046_RS21760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GK046_RS21765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GK046_RS21775	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GK046_RS21785	COG2989	Protein conserved in bacteria
GK046_RS21790	COG3108	Peptidase M15
GK046_RS21795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GK046_RS21800	COG1448	Aminotransferase
GK046_RS21820	COG0308	aminopeptidase N
GK046_RS21830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GK046_RS21840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GK046_RS21845	COG0431	NADPH-dependent FMN reductase
GK046_RS21850	COG3539	Fimbrial protein
GK046_RS21855	COG3121	Chaperone
GK046_RS21860	COG3188	usher protein
GK046_RS21865	COG3539	Fimbrial protein
GK046_RS21870	COG3539	Fimbrial protein
GK046_RS21875	COG3539	Fimbrial protein
GK046_RS21880	COG3121	Chaperone
GK046_RS21895	COG3217	Mosc domain protein beta barrel domain protein
GK046_RS21895	COG0633	Ferredoxin
GK046_RS21905	COG0488	(ABC) transporter
GK046_RS21910	COG2995	paraquat-inducible protein a
GK046_RS21915	COG3008	intermembrane lipid transfer
GK046_RS21915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GK046_RS21920	COG3009	Protein conserved in bacteria
GK046_RS21925	COG3130	regulation of translation
GK046_RS21935	COG1067	ATP-dependent peptidase activity
GK046_RS21945	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GK046_RS21945	COG2885	chlorophyll binding
GK046_RS21955	COG3070	regulator of competence-specific genes
GK046_RS21960	COG1289	transmembrane transporter activity
GK046_RS21965	COG3304	Inner membrane component domain
GK046_RS21970	COG0210	DNA helicase
GK046_RS21985	COG1832	CoA-binding protein
GK046_RS22000	COG1254	Belongs to the acylphosphatase family
GK046_RS22005	COG2920	part of a sulfur-relay system
GK046_RS22010	COG0670	Belongs to the BI1 family
GK046_RS22020	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GK046_RS22025	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GK046_RS22030	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
GK046_RS22035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GK046_RS22040	COG1999	signal sequence binding
GK046_RS22045	COG1773	rubredoxin
GK046_RS22050	COG1271	oxidase subunit
GK046_RS22055	COG1294	oxidase, subunit
GK046_RS22070	COG0489	protein tyrosine kinase activity
GK046_RS22070	COG3206	protein involved in exopolysaccharide biosynthesis
GK046_RS22075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GK046_RS22080	COG1596	polysaccharide export
GK046_RS22085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GK046_RS22105	COG1278	Cold shock
GK046_RS22110	COG1278	Cold shock
GK046_RS22130	COG0348	domain, Protein
GK046_RS22135	COG2205	protein histidine kinase activity
GK046_RS22135	COG0784	Response regulator, receiver
GK046_RS22135	COG2198	Histidine kinase
GK046_RS22140	COG1879	ABC-type sugar transport system periplasmic component
GK046_RS22145	COG0745	RESPONSE REGULATOR receiver
GK046_RS22150	COG3005	denitrification pathway
GK046_RS22155	COG0243	molybdopterin cofactor binding
GK046_RS22195	COG3729	General stress protein
GK046_RS22200	COG2233	PERMEase
GK046_RS22235	COG1309	transcriptional regulator
GK046_RS22240	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GK046_RS22240	COG0506	proline dehydrogenase activity
GK046_RS22240	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GK046_RS22250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GK046_RS22260	COG2822	iron ion transport
GK046_RS22270	COG1702	phosphate starvation-inducible protein PhoH
GK046_RS22275	COG3658	cytochrome
GK046_RS22280	COG1215	transferase activity, transferring glycosyl groups
GK046_RS22285	COG1649	PFAM Uncharacterised BCR, COG1649
GK046_RS22285	COG0726	polysaccharide deacetylase
GK046_RS22290	COG0457	Tetratricopeptide repeat
GK046_RS22295	COG3706	GGDEF domain
GK046_RS22345	COG3381	protein complex oligomerization
GK046_RS22355	COG1462	curli production assembly transport component CsgG
GK046_RS22370	COG2197	response regulator
GK046_RS22395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GK046_RS22400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GK046_RS22415	COG2943	transferase activity, transferring hexosyl groups
GK046_RS22420	COG5645	(Lipo)protein
GK046_RS22435	COG1560	Kdo2-lipid A biosynthetic process
GK046_RS22445	COG2353	YceI-like domain
GK046_RS22450	COG3038	cytochrome b561
GK046_RS22485	COG2999	glutathione oxidoreductase activity
GK046_RS22495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GK046_RS22505	COG0673	inositol 2-dehydrogenase activity
GK046_RS22510	COG0728	peptidoglycan biosynthetic process
GK046_RS22515	COG3418	PFAM FlgN family protein
GK046_RS22520	COG2747	anti-sigma28 factor FlgM
GK046_RS22525	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GK046_RS22530	COG1815	bacterial-type flagellum-dependent cell motility
GK046_RS22535	COG1558	bacterial-type flagellum-dependent cell motility
GK046_RS22540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GK046_RS22545	COG1749	Flagellar hook protein flgE
GK046_RS22550	COG4787	bacterial-type flagellum-dependent cell motility
GK046_RS22555	COG4786	Flagellar basal body rod
GK046_RS22570	COG1705	Flagellar rod assembly protein muramidase FlgJ
GK046_RS22570	COG3951	Flagellar rod assembly protein muramidase FlgJ
GK046_RS22575	COG1256	bacterial-type flagellum assembly
GK046_RS22580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GK046_RS22585	COG1530	ribonuclease E activity
GK046_RS22590	COG0564	pseudouridine synthase activity
GK046_RS22595	COG0424	maF-like protein
GK046_RS22600	COG1399	metal-binding, possibly nucleic acid-binding protein
GK046_RS22620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GK046_RS22625	COG1028	Short-chain dehydrogenase reductase Sdr
GK046_RS22635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GK046_RS22640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GK046_RS22645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GK046_RS22655	COG0470	DNA polymerase III
GK046_RS22660	COG0084	hydrolase, TatD family'
GK046_RS22665	COG1263	PTS System
GK046_RS22665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GK046_RS22670	COG4773	Receptor
GK046_RS22675	COG0537	adenosine 5'-monophosphoramidase activity
GK046_RS22680	COG5633	Lipoprotein
GK046_RS22685	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
GK046_RS22690	COG0510	thiamine kinase activity
GK046_RS22705	COG1252	NADH dehydrogenase
GK046_RS22710	COG3134	Outer membrane lipoprotein
GK046_RS22715	COG1309	transcriptional regulator
GK046_RS22725	COG1388	LysM domain
GK046_RS22725	COG1376	ErfK ybiS ycfS ynhG family protein
GK046_RS22730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GK046_RS22735	COG4763	Acyl-transferase
GK046_RS22740	COG4591	ABC-type transport system involved in lipoprotein release permease component
GK046_RS22745	COG1136	(ABC) transporter
GK046_RS22750	COG4591	ABC-type transport system involved in lipoprotein release permease component
GK046_RS22760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GK046_RS22765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GK046_RS22775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GK046_RS22780	COG1177	transmembrane transport
GK046_RS22790	COG3842	ATPase activity
GK046_RS22800	COG2850	peptidyl-arginine hydroxylation
GK046_RS22805	COG2205	protein histidine kinase activity
GK046_RS22815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GK046_RS22835	COG1187	pseudouridine synthase activity
GK046_RS22840	COG0538	isocitrate dehydrogenase activity
GK046_RS22855	COG5562	phage envelope protein
GK046_RS22860	COG0789	Transcriptional regulator
GK046_RS22865	COG2200	EAL domain
GK046_RS22890	COG2200	EAL domain
GK046_RS22945	COG2894	cell division
GK046_RS22970	COG0179	Fumarylacetoacetate (FAA) hydrolase
GK046_RS22990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GK046_RS22995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GK046_RS23015	COG2719	SpoVR family
GK046_RS23025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GK046_RS23035	COG1619	proteins homologs of microcin C7 resistance protein MccF
GK046_RS23045	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GK046_RS23065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GK046_RS23065	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GK046_RS23065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GK046_RS23070	COG1461	Dihydroxyacetone kinase
GK046_RS23075	COG2376	Dihydroxyacetone kinase
GK046_RS23080	COG3284	Transcriptional regulator
GK046_RS23085	COG3468	outer membrane autotransporter barrel domain protein
GK046_RS23090	COG0012	GTP binding
GK046_RS23105	COG0659	secondary active sulfate transmembrane transporter activity
GK046_RS23110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GK046_RS23135	COG2890	protein-(glutamine-N5) methyltransferase activity
GK046_RS23140	COG3094	Invasion gene expression up-regulator, SirB
GK046_RS23145	COG2912	Transglutaminase-like superfamily
GK046_RS23170	COG0387	Pfam Sodium calcium exchanger
GK046_RS23175	COG4572	Cation transport regulator
GK046_RS23180	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GK046_RS23185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GK046_RS23190	COG4932	domain protein
GK046_RS23195	COG2197	response regulator
GK046_RS23200	COG3850	Histidine kinase
GK046_RS23205	COG2223	nitrite transmembrane transporter activity
GK046_RS23210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GK046_RS23215	COG1140	nitrate reductase beta subunit
GK046_RS23220	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GK046_RS23225	COG2181	nitrate reductase activity
GK046_RS23250	COG0788	formyltetrahydrofolate deformylase activity
GK046_RS23260	COG1752	Esterase of the alpha-beta hydrolase superfamily
GK046_RS23265	COG0745	RESPONSE REGULATOR receiver
GK046_RS23270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GK046_RS23280	COG1435	thymidine kinase activity
GK046_RS23285	COG1454	alcohol dehydrogenase
GK046_RS23285	COG1012	belongs to the aldehyde dehydrogenase family
GK046_RS23290	COG2095	MarC family integral membrane protein
GK046_RS23300	COG4166	transmembrane transport
GK046_RS23305	COG0601	transmembrane transport
GK046_RS23310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GK046_RS23315	COG0444	Belongs to the ABC transporter superfamily
GK046_RS23320	COG4608	Belongs to the ABC transporter superfamily
GK046_RS23340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GK046_RS23345	COG2350	Protein conserved in bacteria
GK046_RS23395	COG1607	acyl-coa hydrolase
GK046_RS23415	COG3047	cAMP biosynthetic process
GK046_RS23420	COG0582	viral genome integration into host DNA
GK046_RS23430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GK046_RS23485	COG3756	Protein conserved in bacteria
GK046_RS23495	COG1846	Transcriptional regulator
GK046_RS23545	COG1403	HNH endonuclease
GK046_RS23550	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GK046_RS23555	COG0484	heat shock protein binding
GK046_RS23610	COG3772	lysozyme
GK046_RS23680	COG0697	spore germination
GK046_RS23795	COG0840	transmembrane signaling receptor activity
GK046_RS23815	COG3119	arylsulfatase activity
GK046_RS23920	COG3385	transposase activity
GK046_RS23975	COG1475	DNA binding
GK046_RS24090	COG3436	PFAM IS66 Orf2 family protein
GK046_RS24095	COG4372	Transposase
GK046_RS24105	COG1560	Kdo2-lipid A biosynthetic process
GK046_RS24110	COG2194	sulfuric ester hydrolase activity
GK046_RS24115	COG0297	glycogen (starch) synthase activity
GK046_RS24120	COG0726	polysaccharide deacetylase
GK046_RS24155	COG2801	Transposase and inactivated derivatives
GK046_RS24175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GK046_RS24290	COG3039	Transposase
GK046_RS24310	COG0673	inositol 2-dehydrogenase activity