locus-tag	class	description
E3Z24_RS00010	COG0592	DNA-directed DNA polymerase activity
E3Z24_RS00020	COG0187	DNA topoisomerase II activity
E3Z24_RS00025	COG3753	Protein conserved in bacteria
E3Z24_RS00030	COG0561	phosphatase activity
E3Z24_RS00040	COG2186	Transcriptional regulator
E3Z24_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
E3Z24_RS00050	COG0800	Aldolase
E3Z24_RS00060	COG2271	Major facilitator Superfamily
E3Z24_RS00065	COG0644	oxidoreductase
E3Z24_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
E3Z24_RS00075	COG5645	(Lipo)protein
E3Z24_RS00095	COG2188	Transcriptional regulator
E3Z24_RS00110	COG2207	Transcriptional regulator
E3Z24_RS00115	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3Z24_RS00120	COG3119	arylsulfatase activity
E3Z24_RS00130	COG2149	membrane
E3Z24_RS00140	COG0641	radical SAM
E3Z24_RS00145	COG2814	Major facilitator Superfamily
E3Z24_RS00165	COG0028	Belongs to the TPP enzyme family
E3Z24_RS00170	COG0440	acetolactate synthase activity
E3Z24_RS00175	COG2197	response regulator
E3Z24_RS00180	COG3851	Histidine kinase
E3Z24_RS00185	COG2271	Major facilitator Superfamily
E3Z24_RS00190	COG2271	Major facilitator Superfamily
E3Z24_RS00200	COG2252	PERMEase
E3Z24_RS00220	COG1464	Belongs to the NlpA lipoprotein family
E3Z24_RS00225	COG0697	spore germination
E3Z24_RS00230	COG2814	Major facilitator Superfamily
E3Z24_RS00245	COG2211	Major facilitator Superfamily
E3Z24_RS00250	COG1501	Belongs to the glycosyl hydrolase 31 family
E3Z24_RS00255	COG2982	Protein involved in outer membrane biogenesis
E3Z24_RS00260	COG2233	PERMEase
E3Z24_RS00265	COG0786	glutamate:sodium symporter activity
E3Z24_RS00270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3Z24_RS00275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3Z24_RS00280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3Z24_RS00290	COG0194	GDP metabolic process
E3Z24_RS00300	COG2860	membrane
E3Z24_RS00305	COG3645	SOS response
E3Z24_RS00315	COG1561	YicC-like family, N-terminal region
E3Z24_RS00340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3Z24_RS00370	COG1519	Transferase
E3Z24_RS00375	COG0859	PFAM glycosyl transferase family 9
E3Z24_RS00380	COG0438	transferase activity, transferring glycosyl groups
E3Z24_RS00385	COG0515	serine threonine protein kinase
E3Z24_RS00390	COG1442	glycosyl transferase family 8
E3Z24_RS00395	COG0438	transferase activity, transferring glycosyl groups
E3Z24_RS00400	COG1442	glycosyl transferase family 8
E3Z24_RS00405	COG1442	glycosyl transferase family 8
E3Z24_RS00410	COG3642	lipopolysaccharide core region biosynthetic process
E3Z24_RS00430	COG0859	PFAM glycosyl transferase family 9
E3Z24_RS00435	COG0859	PFAM glycosyl transferase family 9
E3Z24_RS00445	COG0156	8-amino-7-oxononanoate synthase activity
E3Z24_RS00455	COG1216	Glycosyl transferase, family 2
E3Z24_RS00460	COG2861	carbohydrate metabolic process
E3Z24_RS00465	COG4942	peptidase
E3Z24_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3Z24_RS00480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3Z24_RS00495	COG1045	serine acetyltransferase
E3Z24_RS00500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3Z24_RS00510	COG2186	Transcriptional regulator
E3Z24_RS00515	COG1620	l-lactate permease
E3Z24_RS00530	COG3722	fumarate hydratase activity
E3Z24_RS00540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS00540	COG2213	PTS system mannitol-specific
E3Z24_RS00550	COG1566	PFAM secretion protein HlyD family protein
E3Z24_RS00570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3Z24_RS00590	COG1413	lyase activity
E3Z24_RS00595	COG3209	COG3209 Rhs family protein
E3Z24_RS00600	COG0625	glutathione transferase activity
E3Z24_RS00610	COG3276	selenocysteine insertion sequence binding
E3Z24_RS00615	COG1454	alcohol dehydrogenase
E3Z24_RS00620	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS00635	COG1566	PFAM secretion protein HlyD family protein
E3Z24_RS00640	COG0583	DNA-binding transcription factor activity
E3Z24_RS00645	COG3713	MltA-interacting MipA family protein
E3Z24_RS00655	COG0235	Class ii aldolase
E3Z24_RS00660	COG3623	hexulose-6-phosphate isomerase
E3Z24_RS00665	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E3Z24_RS00670	COG1070	Carbohydrate kinase
E3Z24_RS00675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E3Z24_RS00680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E3Z24_RS00685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E3Z24_RS00690	COG2731	YhcH YjgK YiaL family protein
E3Z24_RS00700	COG1414	Transcriptional regulator
E3Z24_RS00705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS00710	COG3977	Valine--pyruvate aminotransferase
E3Z24_RS00715	COG0366	Alpha amylase catalytic
E3Z24_RS00720	COG2992	FlgJ-related protein
E3Z24_RS00725	COG1609	Transcriptional regulator
E3Z24_RS00725	COG2207	Transcriptional regulator
E3Z24_RS00730	COG4214	carbohydrate transport
E3Z24_RS00735	COG1129	ABC transporter
E3Z24_RS00740	COG4213	ABC transporter substrate-binding protein
E3Z24_RS00750	COG1070	Carbohydrate kinase
E3Z24_RS00755	COG4682	membrane
E3Z24_RS00760	COG4682	membrane
E3Z24_RS00765	COG3274	enterobacterial common antigen metabolic process
E3Z24_RS00795	COG1278	Cold shock
E3Z24_RS00800	COG2944	sequence-specific DNA binding
E3Z24_RS00815	COG2885	chlorophyll binding
E3Z24_RS00820	COG0243	molybdopterin cofactor binding
E3Z24_RS00825	COG0456	acetyltransferase
E3Z24_RS00830	COG2818	Glycosylase
E3Z24_RS00835	COG5571	outer membrane autotransporter
E3Z24_RS00840	COG2223	nitrite transmembrane transporter activity
E3Z24_RS00845	COG2194	sulfuric ester hydrolase activity
E3Z24_RS00855	COG0747	negative chemotaxis
E3Z24_RS00865	COG0601	transmembrane transport
E3Z24_RS00870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z24_RS00875	COG0444	Belongs to the ABC transporter superfamily
E3Z24_RS00880	COG4608	Belongs to the ABC transporter superfamily
E3Z24_RS00885	COG0814	amino acid
E3Z24_RS00900	COG2194	sulfuric ester hydrolase activity
E3Z24_RS00925	COG1215	transferase activity, transferring glycosyl groups
E3Z24_RS00930	COG1215	transferase activity, transferring glycosyl groups
E3Z24_RS00935	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E3Z24_RS00940	COG3118	belongs to the thioredoxin family
E3Z24_RS00940	COG0457	Tetratricopeptide repeat
E3Z24_RS00945	COG2199	diguanylate cyclase activity
E3Z24_RS00945	COG2200	EAL domain
E3Z24_RS00955	COG0612	Peptidase, M16
E3Z24_RS00960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS00965	COG2200	EAL domain
E3Z24_RS00970	COG2982	Protein involved in outer membrane biogenesis
E3Z24_RS00975	COG0477	Major facilitator Superfamily
E3Z24_RS00980	COG1295	ribonuclease BN
E3Z24_RS00985	COG0583	DNA-binding transcription factor activity
E3Z24_RS00990	COG2197	response regulator
E3Z24_RS01000	COG1858	cytochrome C peroxidase
E3Z24_RS01005	COG0076	glutamate decarboxylase activity
E3Z24_RS01010	COG2207	Transcriptional regulator
E3Z24_RS01015	COG2207	Transcriptional regulator
E3Z24_RS01020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3Z24_RS01025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z24_RS01035	COG2771	luxR family
E3Z24_RS01040	COG3247	response to pH
E3Z24_RS01055	COG1285	pathogenesis
E3Z24_RS01060	COG2197	response regulator
E3Z24_RS01065	COG3065	identical protein binding
E3Z24_RS01075	COG1393	Belongs to the ArsC family
E3Z24_RS01080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3Z24_RS01085	COG0640	Transcriptional regulator
E3Z24_RS01095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3Z24_RS01100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3Z24_RS01105	COG0339	signal peptide processing
E3Z24_RS01115	COG3104	oligopeptide transport
E3Z24_RS01120	COG0589	response to stress
E3Z24_RS01130	COG0306	phosphate transporter
E3Z24_RS01135	COG2081	HI0933 family
E3Z24_RS01155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z24_RS01160	COG1129	ABC transporter
E3Z24_RS01160	COG0842	Transport permease protein
E3Z24_RS01165	COG0842	Transport permease protein
E3Z24_RS01170	COG5433	transposase activity
E3Z24_RS01175	COG1413	lyase activity
E3Z24_RS01185	COG3209	COG3209 Rhs family protein
E3Z24_RS01195	COG1124	(ABC) transporter
E3Z24_RS01200	COG0444	Belongs to the ABC transporter superfamily
E3Z24_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z24_RS01210	COG0601	transmembrane transport
E3Z24_RS01215	COG0747	negative chemotaxis
E3Z24_RS01220	COG2091	lysine biosynthetic process via aminoadipic acid
E3Z24_RS01225	COG0628	permease
E3Z24_RS01230	COG0477	Major facilitator Superfamily
E3Z24_RS01240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3Z24_RS01250	COG2217	Heavy metal translocating P-type atpase
E3Z24_RS01255	COG3714	YhhN family
E3Z24_RS01265	COG3776	membrane
E3Z24_RS01270	COG0742	ribosomal rna small subunit methyltransferase
E3Z24_RS01275	COG0552	protein localization to endoplasmic reticulum
E3Z24_RS01280	COG2884	Cell division ATP-binding protein ftsE
E3Z24_RS01285	COG2177	Part of the ABC transporter FtsEX involved in
E3Z24_RS01290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3Z24_RS01295	COG0683	leucine binding
E3Z24_RS01300	COG0456	acetyltransferase
E3Z24_RS01305	COG0683	leucine binding
E3Z24_RS01310	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS01315	COG4177	L-phenylalanine transmembrane transporter activity
E3Z24_RS01320	COG0411	ABC transporter
E3Z24_RS01325	COG0410	ABC transporter
E3Z24_RS01330	COG1653	transport
E3Z24_RS01335	COG1175	transmembrane transport
E3Z24_RS01340	COG0395	ABC-type sugar transport system, permease component
E3Z24_RS01345	COG3842	ATPase activity
E3Z24_RS01350	COG0584	glycerophosphoryl diester phosphodiesterase
E3Z24_RS01360	COG0405	Gamma-glutamyltransferase
E3Z24_RS01385	COG3157	Type VI secretion system effector, Hcp
E3Z24_RS01390	COG1247	-acetyltransferase
E3Z24_RS01395	COG0673	inositol 2-dehydrogenase activity
E3Z24_RS01400	COG1741	Belongs to the pirin family
E3Z24_RS01405	COG1609	Transcriptional regulator
E3Z24_RS01410	COG3265	gluconokinase activity
E3Z24_RS01415	COG2610	gluconate transmembrane transporter activity
E3Z24_RS01420	COG2095	MarC family integral membrane protein
E3Z24_RS01425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3Z24_RS01450	COG0058	SHG alpha-glucan phosphorylase activity
E3Z24_RS01460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3Z24_RS01475	COG1349	DNA-binding transcription factor activity
E3Z24_RS01480	COG4650	regulator
E3Z24_RS01485	COG1690	Belongs to the RtcB family
E3Z24_RS01500	COG0058	SHG alpha-glucan phosphorylase activity
E3Z24_RS01505	COG1640	4-alpha-glucanotransferase
E3Z24_RS01510	COG2610	gluconate transmembrane transporter activity
E3Z24_RS01520	COG1040	competence protein
E3Z24_RS01530	COG5464	transposase or invertase
E3Z24_RS01540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E3Z24_RS01545	COG1918	ferrous iron import across plasma membrane
E3Z24_RS01550	COG2183	response to ionizing radiation
E3Z24_RS01555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z24_RS01575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3Z24_RS01585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3Z24_RS01590	COG1011	Hydrolase
E3Z24_RS01600	COG0494	nUDIX hydrolase
E3Z24_RS01605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E3Z24_RS01610	COG4972	Pilus assembly protein
E3Z24_RS01615	COG3166	PFAM Fimbrial assembly family protein
E3Z24_RS01630	COG4796	Type ii and iii secretion system protein
E3Z24_RS01645	COG3266	domain, Protein
E3Z24_RS01650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E3Z24_RS01655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3Z24_RS01660	COG0546	phosphoglycolate phosphatase activity
E3Z24_RS01665	COG0180	Tryptophanyl-tRNA synthetase
E3Z24_RS01675	COG2188	Transcriptional regulator
E3Z24_RS01685	COG3457	Alanine racemase
E3Z24_RS01690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E3Z24_RS01695	COG1735	metal-dependent hydrolase with the TIM-barrel fold
E3Z24_RS01710	COG0626	cystathionine gamma-synthase activity
E3Z24_RS01715	COG2188	Transcriptional regulator
E3Z24_RS01720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS01725	COG1082	Xylose isomerase domain protein TIM barrel
E3Z24_RS01730	COG2222	sugar isomerase
E3Z24_RS01735	COG0531	amino acid
E3Z24_RS01750	COG2116	formate transmembrane transporter activity
E3Z24_RS01755	COG2146	nitrite reductase [NAD(P)H] activity
E3Z24_RS01760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3Z24_RS01770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3Z24_RS01780	COG2184	nucleotidyltransferase activity
E3Z24_RS01785	COG0512	Glutamine amidotransferase of anthranilate synthase
E3Z24_RS01790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3Z24_RS01795	COG1289	transmembrane transporter activity
E3Z24_RS01800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z24_RS01805	COG1765	OsmC-like protein
E3Z24_RS01810	COG3954	Phosphoribulokinase
E3Z24_RS01820	COG0429	hydrolase of the alpha beta-hydrolase fold
E3Z24_RS01825	COG0488	(ABC) transporter
E3Z24_RS01840	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3Z24_RS01845	COG1047	Peptidyl-prolyl cis-trans
E3Z24_RS01855	COG0545	Peptidyl-prolyl cis-trans isomerase
E3Z24_RS01860	COG2964	Protein conserved in bacteria
E3Z24_RS01900	COG3979	chitinase
E3Z24_RS01905	COG2906	2 iron, 2 sulfur cluster binding
E3Z24_RS01910	COG2193	ferroxidase activity
E3Z24_RS01915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3Z24_RS01920	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E3Z24_RS01925	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E3Z24_RS01930	COG3156	type II secretion system protein K
E3Z24_RS01935	COG4795	General secretion pathway protein
E3Z24_RS01940	COG2165	general secretion pathway protein
E3Z24_RS01945	COG2165	general secretion pathway protein
E3Z24_RS01950	COG2165	general secretion pathway protein
E3Z24_RS01955	COG1459	type II secretion system
E3Z24_RS01960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3Z24_RS01965	COG1450	Type ii and iii secretion system protein
E3Z24_RS01970	COG3031	protein transport across the cell outer membrane
E3Z24_RS01975	COG3267	Type II secretory pathway component ExeA
E3Z24_RS01975	COG3409	Peptidoglycan-binding domain 1 protein
E3Z24_RS02000	COG0089	rRNA binding
E3Z24_RS02090	COG0201	protein transport
E3Z24_RS02130	COG0789	Transcriptional regulator
E3Z24_RS02135	COG3036	rescue of stalled ribosome
E3Z24_RS02145	COG0569	domain protein
E3Z24_RS02165	COG0758	DNA mediated transformation
E3Z24_RS02175	COG0551	DNA topoisomerase type I activity
E3Z24_RS02195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3Z24_RS02240	COG1126	abc transporter atp-binding protein
E3Z24_RS02245	COG0765	amino acid transport
E3Z24_RS02250	COG4597	amino acid ABC transporter
E3Z24_RS02255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3Z24_RS02285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3Z24_RS02295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3Z24_RS02305	COG4145	pantothenate transmembrane transporter activity
E3Z24_RS02310	COG3924	membrane
E3Z24_RS02315	COG0439	Biotin carboxylase
E3Z24_RS02320	COG0511	ligase activity, forming carbon-carbon bonds
E3Z24_RS02325	COG0604	alcohol dehydrogenase
E3Z24_RS02330	COG2200	EAL domain
E3Z24_RS02330	COG2199	diguanylate cyclase activity
E3Z24_RS02335	COG1077	Cell shape determining protein MreB Mrl
E3Z24_RS02340	COG1792	Involved in formation and maintenance of cell shape
E3Z24_RS02345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3Z24_RS02350	COG0424	maF-like protein
E3Z24_RS02355	COG1530	ribonuclease E activity
E3Z24_RS02360	COG3164	Protein of unknown function
E3Z24_RS02365	COG0312	modulator of DNA gyrase
E3Z24_RS02370	COG0583	DNA-binding transcription factor activity
E3Z24_RS02390	COG2732	(Barnase) inhibitor
E3Z24_RS02410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3Z24_RS02415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3Z24_RS02420	COG3105	Protein conserved in bacteria
E3Z24_RS02425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3Z24_RS02440	COG0625	glutathione transferase activity
E3Z24_RS02445	COG2969	positive regulation of protein catabolic process
E3Z24_RS02450	COG3069	C4-dicarboxylate transmembrane transporter activity
E3Z24_RS02480	COG2731	YhcH YjgK YiaL family protein
E3Z24_RS02485	COG4804	nuclease activity
E3Z24_RS02500	COG3344	reverse transcriptase
E3Z24_RS02515	COG3539	Fimbrial protein
E3Z24_RS02525	COG3188	usher protein
E3Z24_RS02530	COG3121	Chaperone
E3Z24_RS02535	COG3539	Fimbrial protein
E3Z24_RS02540	COG0493	'glutamate synthase
E3Z24_RS02545	COG0070	glutamate synthase
E3Z24_RS02545	COG0067	glutamate synthase
E3Z24_RS02545	COG0069	glutamate synthase activity
E3Z24_RS02550	COG1242	4 iron, 4 sulfur cluster binding
E3Z24_RS02555	COG0784	Response regulator, receiver
E3Z24_RS02555	COG5002	protein histidine kinase activity
E3Z24_RS02555	COG2198	Histidine kinase
E3Z24_RS02560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3Z24_RS02570	COG0515	serine threonine protein kinase
E3Z24_RS02575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS02590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3Z24_RS02595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3Z24_RS02600	COG1137	ATPase activity
E3Z24_RS02605	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3Z24_RS02610	COG3117	lipopolysaccharide transmembrane transporter activity
E3Z24_RS02615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3Z24_RS02620	COG0517	IMP dehydrogenase activity
E3Z24_RS02620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3Z24_RS02625	COG0530	calcium, potassium:sodium antiporter activity
E3Z24_RS02630	COG1127	ABC transporter
E3Z24_RS02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3Z24_RS02640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3Z24_RS02645	COG2854	intermembrane phospholipid transfer
E3Z24_RS02650	COG3113	response to antibiotic
E3Z24_RS02655	COG5007	Belongs to the BolA IbaG family
E3Z24_RS02665	COG3423	Transcriptional regulator
E3Z24_RS02670	COG0142	geranyltranstransferase activity
E3Z24_RS02685	COG0697	spore germination
E3Z24_RS02695	COG2027	D-alanyl-D-alanine carboxypeptidase
E3Z24_RS02700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z24_RS02705	COG1534	Rna-binding protein
E3Z24_RS02715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3Z24_RS02720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3Z24_RS02730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3Z24_RS02740	COG2194	sulfuric ester hydrolase activity
E3Z24_RS02760	COG0195	Participates in both transcription termination and antitermination
E3Z24_RS02800	COG0513	Belongs to the DEAD box helicase family
E3Z24_RS02805	COG0814	amino acid
E3Z24_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3Z24_RS02815	COG0826	peptidase U32
E3Z24_RS02820	COG0826	peptidase U32
E3Z24_RS02825	COG3154	lipid carrier protein
E3Z24_RS02830	COG3153	acetyltransferase
E3Z24_RS02845	COG0693	protein deglycase activity
E3Z24_RS02850	COG0702	epimerase
E3Z24_RS02855	COG0701	Predicted permease
E3Z24_RS02860	COG2823	Periplasmic or secreted lipoprotein
E3Z24_RS02875	COG3107	peptidoglycan biosynthetic process
E3Z24_RS02880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3Z24_RS02885	COG3539	Fimbrial protein
E3Z24_RS02890	COG3188	usher protein
E3Z24_RS02895	COG3121	Chaperone
E3Z24_RS02900	COG3539	Fimbrial protein
E3Z24_RS02905	COG0363	glucosamine-6-phosphate deaminase activity
E3Z24_RS02910	COG3716	PTS system mannose fructose sorbose family IID component
E3Z24_RS02915	COG3715	PTS system
E3Z24_RS02925	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS02935	COG2222	sugar isomerase
E3Z24_RS02940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3Z24_RS02945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS02950	COG3716	PTS system mannose fructose sorbose family IID component
E3Z24_RS02960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS02970	COG1349	DNA-binding transcription factor activity
E3Z24_RS02980	COG2002	toxin-antitoxin pair type II binding
E3Z24_RS02985	COG2721	sulfolactate sulfo-lyase activity
E3Z24_RS02990	COG2271	Major facilitator Superfamily
E3Z24_RS03000	COG2084	Dehydrogenase
E3Z24_RS03005	COG1929	Belongs to the glycerate kinase type-1 family
E3Z24_RS03030	COG0583	DNA-binding transcription factor activity
E3Z24_RS03035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3Z24_RS03045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3Z24_RS03050	COG1882	Formate acetyltransferase
E3Z24_RS03055	COG0251	oxidation-reduction process
E3Z24_RS03060	COG1760	l-serine dehydratase
E3Z24_RS03065	COG0814	amino acid
E3Z24_RS03080	COG1741	Belongs to the pirin family
E3Z24_RS03085	COG0583	DNA-binding transcription factor activity
E3Z24_RS03090	COG3152	Membrane
E3Z24_RS03100	COG3152	Membrane
E3Z24_RS03105	COG0435	Glutathione S-transferase
E3Z24_RS03110	COG2259	Doxx family
E3Z24_RS03120	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E3Z24_RS03125	COG4575	ribosome binding
E3Z24_RS03130	COG1422	Protein of unknown function (DUF1090)
E3Z24_RS03140	COG0586	Pfam SNARE associated Golgi protein
E3Z24_RS03145	COG2186	Transcriptional regulator
E3Z24_RS03150	COG2271	Major facilitator Superfamily
E3Z24_RS03160	COG2721	sulfolactate sulfo-lyase activity
E3Z24_RS03170	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E3Z24_RS03175	COG0861	Integral membrane protein TerC family
E3Z24_RS03180	COG0673	inositol 2-dehydrogenase activity
E3Z24_RS03185	COG2949	membrane
E3Z24_RS03190	COG1451	nucleotide metabolic process
E3Z24_RS03200	COG4680	protein conserved in bacteria
E3Z24_RS03205	COG5499	transcription regulator containing HTH domain
E3Z24_RS03210	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3Z24_RS03210	COG1902	pentaerythritol trinitrate reductase activity
E3Z24_RS03215	COG3408	Glycogen debranching enzyme
E3Z24_RS03215	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E3Z24_RS03225	COG0531	amino acid
E3Z24_RS03230	COG2731	YhcH YjgK YiaL family protein
E3Z24_RS03235	COG3250	beta-galactosidase activity
E3Z24_RS03240	COG1609	Transcriptional regulator
E3Z24_RS03245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3Z24_RS03255	COG0840	transmembrane signaling receptor activity
E3Z24_RS03260	COG1695	Transcriptional regulator
E3Z24_RS03265	COG2375	cellular response to nickel ion
E3Z24_RS03280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3Z24_RS03285	COG0358	DNA primase activity
E3Z24_RS03290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3Z24_RS03300	COG0471	metal ion transport
E3Z24_RS03305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3Z24_RS03310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3Z24_RS03315	COG0583	DNA-binding transcription factor activity
E3Z24_RS03325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3Z24_RS03340	COG4991	sh3 domain protein
E3Z24_RS03345	COG3025	triphosphatase activity
E3Z24_RS03370	COG2268	Band 7 protein
E3Z24_RS03380	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3Z24_RS03390	COG3539	Fimbrial protein
E3Z24_RS03395	COG3121	Chaperone
E3Z24_RS03400	COG3188	usher protein
E3Z24_RS03415	COG3539	Fimbrial protein
E3Z24_RS03420	COG2960	long-chain fatty acid transporting porin activity
E3Z24_RS03435	COG3384	dioxygenase
E3Z24_RS03440	COG0754	glutathionylspermidine amidase activity
E3Z24_RS03450	COG1538	Outer membrane efflux protein
E3Z24_RS03455	COG0494	nUDIX hydrolase
E3Z24_RS03460	COG3151	Protein conserved in bacteria
E3Z24_RS03465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3Z24_RS03470	COG3150	esterase
E3Z24_RS03475	COG0187	DNA topoisomerase II activity
E3Z24_RS03480	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3Z24_RS03485	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3Z24_RS03495	COG0642	Histidine kinase
E3Z24_RS03500	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS03505	COG3111	PFAM Bacterial OB fold (BOF) protein
E3Z24_RS03510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3Z24_RS03520	COG2944	sequence-specific DNA binding
E3Z24_RS03525	COG4166	transmembrane transport
E3Z24_RS03530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3Z24_RS03535	COG0204	Acyl-transferase
E3Z24_RS03540	COG2132	Multicopper oxidase
E3Z24_RS03545	COG1032	radical SAM domain protein
E3Z24_RS03550	COG4238	major outer membrane lipoprotein
E3Z24_RS03560	COG0656	L-ascorbic acid biosynthetic process
E3Z24_RS03565	COG1979	alcohol dehydrogenase
E3Z24_RS03570	COG2207	Transcriptional regulator
E3Z24_RS03575	COG0586	Pfam SNARE associated Golgi protein
E3Z24_RS03580	COG0626	cystathionine gamma-synthase activity
E3Z24_RS03585	COG0811	peptide transport
E3Z24_RS03590	COG0848	biopolymer transport protein
E3Z24_RS03595	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS03605	COG0667	Aldo Keto reductase
E3Z24_RS03620	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3Z24_RS03625	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS03630	COG5557	Pfam Polysulphide reductase, NrfD
E3Z24_RS03635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3Z24_RS03640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3Z24_RS03645	COG1773	rubredoxin
E3Z24_RS03655	COG0298	carbon dioxide binding
E3Z24_RS03660	COG0625	glutathione transferase activity
E3Z24_RS03665	COG0754	glutathionylspermidine amidase activity
E3Z24_RS03670	COG0306	phosphate transporter
E3Z24_RS03675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3Z24_RS03680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3Z24_RS03685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3Z24_RS03690	COG2244	polysaccharide biosynthetic process
E3Z24_RS03700	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E3Z24_RS03705	COG0795	lipopolysaccharide-transporting ATPase activity
E3Z24_RS03715	COG0156	8-amino-7-oxononanoate synthase activity
E3Z24_RS03720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3Z24_RS03730	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z24_RS03735	COG0456	acetyltransferase
E3Z24_RS03740	COG2186	Transcriptional regulator
E3Z24_RS03745	COG0277	FAD linked oxidase domain protein
E3Z24_RS03750	COG0277	FAD linked oxidase domain protein
E3Z24_RS03755	COG0247	lactate metabolic process
E3Z24_RS03760	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E3Z24_RS03765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3Z24_RS03770	COG1620	l-lactate permease
E3Z24_RS03775	COG3064	Membrane
E3Z24_RS03780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3Z24_RS03790	COG3031	protein transport across the cell outer membrane
E3Z24_RS03805	COG1459	type II secretion system
E3Z24_RS03810	COG2165	general secretion pathway protein
E3Z24_RS03840	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E3Z24_RS03875	COG2003	Belongs to the UPF0758 family
E3Z24_RS03900	COG2378	regulation of single-species biofilm formation
E3Z24_RS03905	COG3596	GTP binding
E3Z24_RS03940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3Z24_RS03945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS03950	COG2313	pseudouridylate synthase activity
E3Z24_RS03955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3Z24_RS03960	COG1522	sequence-specific DNA binding
E3Z24_RS03960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS04010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3Z24_RS04015	COG2207	Transcriptional regulator
E3Z24_RS04020	COG2972	Histidine kinase
E3Z24_RS04030	COG3344	reverse transcriptase
E3Z24_RS04050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3Z24_RS04055	COG1882	Formate acetyltransferase
E3Z24_RS04060	COG0693	protein deglycase activity
E3Z24_RS04070	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS04105	COG4820	ethanolamine utilization protein (EutJ)
E3Z24_RS04110	COG4869	propanediol catabolic process
E3Z24_RS04165	COG3969	phosphoadenosine phosphosulfate
E3Z24_RS04170	COG1475	DNA binding
E3Z24_RS04180	COG4584	PFAM Integrase catalytic
E3Z24_RS04185	COG1484	DNA-dependent DNA replication
E3Z24_RS04205	COG1201	RNA secondary structure unwinding
E3Z24_RS04230	COG2194	sulfuric ester hydrolase activity
E3Z24_RS04235	COG0582	viral genome integration into host DNA
E3Z24_RS04245	COG1811	Na channel or pump
E3Z24_RS04250	COG1982	Orn Lys Arg decarboxylase major
E3Z24_RS04255	COG2211	Major facilitator Superfamily
E3Z24_RS04270	COG1194	a g-specific adenine glycosylase
E3Z24_RS04280	COG3171	Protein conserved in bacteria
E3Z24_RS04290	COG0252	asparaginase activity
E3Z24_RS04300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3Z24_RS04305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3Z24_RS04315	COG0762	integral membrane protein
E3Z24_RS04320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3Z24_RS04325	COG2805	Type II/IV secretion system protein
E3Z24_RS04340	COG0189	ligase activity
E3Z24_RS04345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3Z24_RS04350	COG2356	endonuclease I
E3Z24_RS04360	COG2814	Major facilitator Superfamily
E3Z24_RS04375	COG1166	arginine decarboxylase activity
E3Z24_RS04385	COG0501	Belongs to the peptidase M48B family
E3Z24_RS04390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3Z24_RS04395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS04400	COG2213	PTS system mannitol-specific
E3Z24_RS04405	COG1063	alcohol dehydrogenase
E3Z24_RS04410	COG1494	fructose-1,6-bisphosphatase
E3Z24_RS04415	COG3722	fumarate hydratase activity
E3Z24_RS04420	COG1072	(Pantothenic acid kinase))
E3Z24_RS04435	COG0191	fructose-bisphosphate aldolase activity
E3Z24_RS04440	COG0668	transmembrane transport
E3Z24_RS04445	COG1279	arginine transmembrane transporter activity
E3Z24_RS04450	COG2968	Membrane
E3Z24_RS04455	COG0583	DNA-binding transcription factor activity
E3Z24_RS04460	COG0427	acetyl-CoA hydrolase
E3Z24_RS04465	COG1024	Enoyl-CoA hydratase
E3Z24_RS04470	COG1703	isobutyryl-CoA mutase activity
E3Z24_RS04475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3Z24_RS04475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3Z24_RS04495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3Z24_RS04505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3Z24_RS04525	COG0006	proline dipeptidase activity
E3Z24_RS04530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z24_RS04535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z24_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS04565	COG2723	6-phospho-beta-galactosidase activity
E3Z24_RS04575	COG1272	protein, Hemolysin III
E3Z24_RS04585	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3Z24_RS04595	COG0716	FMN binding
E3Z24_RS04600	COG4974	Belongs to the 'phage' integrase family
E3Z24_RS04605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3Z24_RS04610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3Z24_RS04620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3Z24_RS04640	COG2233	PERMEase
E3Z24_RS04645	COG0493	'glutamate synthase
E3Z24_RS04645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS04650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS04655	COG2252	PERMEase
E3Z24_RS04660	COG0402	S-adenosylhomocysteine deaminase activity
E3Z24_RS04665	COG2233	PERMEase
E3Z24_RS04670	COG2080	2 iron, 2 sulfur cluster binding
E3Z24_RS04670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3Z24_RS04675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3Z24_RS04680	COG0402	S-adenosylhomocysteine deaminase activity
E3Z24_RS04685	COG0493	'glutamate synthase
E3Z24_RS04685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS04690	COG2068	MobA-Related Protein
E3Z24_RS04695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3Z24_RS04700	COG3608	succinylglutamate desuccinylase aspartoacylase
E3Z24_RS04700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3Z24_RS04705	COG0549	Belongs to the carbamate kinase family
E3Z24_RS04715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3Z24_RS04720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3Z24_RS04725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3Z24_RS04730	COG3829	transcription factor binding
E3Z24_RS04735	COG2080	2 iron, 2 sulfur cluster binding
E3Z24_RS04740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3Z24_RS04745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3Z24_RS04750	COG4942	peptidase
E3Z24_RS04760	COG4974	Belongs to the 'phage' integrase family
E3Z24_RS04795	COG3385	transposase activity
E3Z24_RS04895	COG0457	Tetratricopeptide repeat
E3Z24_RS04895	COG3710	Transcriptional regulator
E3Z24_RS04900	COG0457	Tetratricopeptide repeat
E3Z24_RS04925	COG3710	Transcriptional regulator
E3Z24_RS04930	COG2771	luxR family
E3Z24_RS04935	COG0814	amino acid
E3Z24_RS04940	COG0183	Belongs to the thiolase family
E3Z24_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS04955	COG2814	Major facilitator Superfamily
E3Z24_RS04960	COG1794	racemase activity, acting on amino acids and derivatives
E3Z24_RS04965	COG0583	DNA-binding transcription factor activity
E3Z24_RS04975	COG1609	Transcriptional regulator
E3Z24_RS04995	COG0667	Aldo Keto reductase
E3Z24_RS05005	COG0861	Integral membrane protein TerC family
E3Z24_RS05025	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E3Z24_RS05040	COG2165	general secretion pathway protein
E3Z24_RS05045	COG4795	General secretion pathway protein
E3Z24_RS05055	COG4967	type IV pilus modification protein PilV
E3Z24_RS05060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3Z24_RS05065	COG1025	Belongs to the peptidase M16 family
E3Z24_RS05070	COG1074	ATP-dependent DNA helicase activity
E3Z24_RS05075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3Z24_RS05080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3Z24_RS05080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3Z24_RS05085	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3Z24_RS05105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E3Z24_RS05110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3Z24_RS05115	COG2166	iron-sulfur cluster assembly
E3Z24_RS05120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3Z24_RS05130	COG0583	DNA-binding transcription factor activity
E3Z24_RS05135	COG2363	Small membrane protein
E3Z24_RS05145	COG1349	DNA-binding transcription factor activity
E3Z24_RS05155	COG1070	Carbohydrate kinase
E3Z24_RS05165	COG0738	Major facilitator superfamily
E3Z24_RS05170	COG0235	Class ii aldolase
E3Z24_RS05175	COG1454	alcohol dehydrogenase
E3Z24_RS05185	COG1760	l-serine dehydratase
E3Z24_RS05190	COG0814	amino acid
E3Z24_RS05195	COG1611	Belongs to the LOG family
E3Z24_RS05210	COG3098	single-species biofilm formation
E3Z24_RS05215	COG0564	pseudouridine synthase activity
E3Z24_RS05220	COG0716	FMN binding
E3Z24_RS05225	COG2271	Major facilitator Superfamily
E3Z24_RS05230	COG4948	Mandelate Racemase Muconate Lactonizing
E3Z24_RS05235	COG4948	Mandelate Racemase Muconate Lactonizing
E3Z24_RS05240	COG4999	Histidine kinase
E3Z24_RS05240	COG2205	protein histidine kinase activity
E3Z24_RS05240	COG3437	response regulator, receiver
E3Z24_RS05240	COG3850	Histidine kinase
E3Z24_RS05245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3Z24_RS05250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3Z24_RS05255	COG2336	PFAM SpoVT AbrB
E3Z24_RS05260	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3Z24_RS05265	COG3956	TIGRFAM MazG family protein
E3Z24_RS05280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3Z24_RS05290	COG0602	queuosine metabolic process
E3Z24_RS05295	COG1070	Carbohydrate kinase
E3Z24_RS05300	COG2223	nitrite transmembrane transporter activity
E3Z24_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS05310	COG0277	FAD linked oxidase domain protein
E3Z24_RS05315	COG0477	Major facilitator Superfamily
E3Z24_RS05320	COG2086	electron transfer activity
E3Z24_RS05325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3Z24_RS05330	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3Z24_RS05335	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3Z24_RS05340	COG0644	oxidoreductase
E3Z24_RS05345	COG0720	synthase
E3Z24_RS05370	COG1203	CRISPR-associated helicase, Cas3
E3Z24_RS05385	COG1857	crispr-associated protein
E3Z24_RS05400	COG1518	maintenance of DNA repeat elements
E3Z24_RS05405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z24_RS05410	COG2234	aminopeptidase activity
E3Z24_RS05465	COG4942	peptidase
E3Z24_RS05465	COG1388	LysM domain
E3Z24_RS05470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3Z24_RS05475	COG2610	gluconate transmembrane transporter activity
E3Z24_RS05480	COG3622	Belongs to the hyi family
E3Z24_RS05485	COG0235	Class ii aldolase
E3Z24_RS05490	COG3395	kinase activity
E3Z24_RS05495	COG2084	Dehydrogenase
E3Z24_RS05500	COG1349	DNA-binding transcription factor activity
E3Z24_RS05505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3Z24_RS05520	COG3604	Transcriptional regulator
E3Z24_RS05525	COG0309	Hydrogenase expression formation protein (HypE)
E3Z24_RS05530	COG0409	Hydrogenase expression formation protein
E3Z24_RS05535	COG0298	carbon dioxide binding
E3Z24_RS05540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E3Z24_RS05545	COG0375	protein maturation
E3Z24_RS05560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS05565	COG0651	ATP synthesis coupled electron transport
E3Z24_RS05570	COG0650	Formate hydrogenlyase subunit 4
E3Z24_RS05575	COG3261	NADH dehydrogenase
E3Z24_RS05575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3Z24_RS05580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z24_RS05585	COG3260	NADH ubiquinone oxidoreductase 20
E3Z24_RS05595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3Z24_RS05600	COG2723	6-phospho-beta-galactosidase activity
E3Z24_RS05605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS05605	COG1263	PTS System
E3Z24_RS05610	COG1609	Transcriptional regulator
E3Z24_RS05615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS05620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E3Z24_RS05640	COG0517	IMP dehydrogenase activity
E3Z24_RS05640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3Z24_RS05645	COG1349	DNA-binding transcription factor activity
E3Z24_RS05650	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS05660	COG3731	PTS system glucitol sorbitol-specific IIA component
E3Z24_RS05665	COG3732	PTS system glucitol sorbitol-specific
E3Z24_RS05670	COG3730	PTS system glucitol sorbitol-specific
E3Z24_RS05675	COG2951	lytic endotransglycosylase activity
E3Z24_RS05680	COG1546	Belongs to the CinA family
E3Z24_RS05700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3Z24_RS05730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z24_RS05735	COG1238	metal cluster binding
E3Z24_RS05750	COG2814	Major facilitator Superfamily
E3Z24_RS05755	COG1566	PFAM secretion protein HlyD family protein
E3Z24_RS05760	COG1846	Transcriptional regulator
E3Z24_RS05770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E3Z24_RS05775	COG2814	Major facilitator Superfamily
E3Z24_RS05780	COG2113	Glycine betaine
E3Z24_RS05785	COG4176	ABC-type proline glycine betaine transport system permease component
E3Z24_RS05790	COG4175	Glycine betaine
E3Z24_RS05795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3Z24_RS05800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3Z24_RS05810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3Z24_RS05815	COG4575	ribosome binding
E3Z24_RS05830	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3Z24_RS05835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3Z24_RS05840	COG0640	Transcriptional regulator
E3Z24_RS05845	COG0401	homolog of Blt101
E3Z24_RS05850	COG1652	LysM domain
E3Z24_RS05855	COG1802	Transcriptional regulator
E3Z24_RS05860	COG1113	amino acid transport
E3Z24_RS05865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z24_RS05870	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS05875	COG0579	oxidoreductase
E3Z24_RS05890	COG0366	Alpha amylase catalytic
E3Z24_RS05915	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS05930	COG2867	negative regulation of translational initiation
E3Z24_RS05940	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z24_RS05945	COG0497	DNA recombination
E3Z24_RS05960	COG4536	flavin adenine dinucleotide binding
E3Z24_RS05965	COG4137	Cytochrome C assembly protein
E3Z24_RS05970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3Z24_RS05995	COG2885	chlorophyll binding
E3Z24_RS06000	COG2199	diguanylate cyclase activity
E3Z24_RS06015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3Z24_RS06020	COG1605	Chorismate mutase
E3Z24_RS06020	COG0287	Prephenate dehydrogenase
E3Z24_RS06025	COG1605	Chorismate mutase
E3Z24_RS06025	COG0077	Prephenate dehydratase
E3Z24_RS06035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3Z24_RS06040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z24_RS06045	COG0564	pseudouridine synthase activity
E3Z24_RS06050	COG1496	oxidoreductase activity
E3Z24_RS06055	COG0542	response to heat
E3Z24_RS06080	COG0477	Major facilitator Superfamily
E3Z24_RS06085	COG5544	Lipoprotein
E3Z24_RS06090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3Z24_RS06095	COG0045	succinate-CoA ligase (ADP-forming) activity
E3Z24_RS06095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3Z24_RS06095	COG1042	CoA-binding domain protein
E3Z24_RS06100	COG3148	PFAM DTW domain containing protein
E3Z24_RS06105	COG3118	belongs to the thioredoxin family
E3Z24_RS06110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3Z24_RS06130	COG0583	DNA-binding transcription factor activity
E3Z24_RS06135	COG0513	Belongs to the DEAD box helicase family
E3Z24_RS06145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3Z24_RS06155	COG1595	DNA-templated transcription, initiation
E3Z24_RS06160	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E3Z24_RS06165	COG3026	antisigma factor binding
E3Z24_RS06170	COG3086	response to oxidative stress
E3Z24_RS06180	COG0681	Belongs to the peptidase S26 family
E3Z24_RS06200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3Z24_RS06215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS06220	COG1737	Transcriptional regulator
E3Z24_RS06225	COG0560	Phosphoserine phosphatase
E3Z24_RS06240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3Z24_RS06240	COG0047	phosphoribosylformylglycinamidine synthase activity
E3Z24_RS06245	COG2205	protein histidine kinase activity
E3Z24_RS06250	COG3170	Tfp pilus assembly protein FimV
E3Z24_RS06255	COG2204	response regulator
E3Z24_RS06260	COG0347	Belongs to the P(II) protein family
E3Z24_RS06265	COG1017	nitric oxide dioxygenase activity
E3Z24_RS06265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z24_RS06275	COG1940	carbohydrate kinase activity
E3Z24_RS06280	COG0457	Tetratricopeptide repeat
E3Z24_RS06285	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS06290	COG1129	ABC transporter
E3Z24_RS06295	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS06300	COG1063	alcohol dehydrogenase
E3Z24_RS06305	COG2017	converts alpha-aldose to the beta-anomer
E3Z24_RS06310	COG2259	Doxx family
E3Z24_RS06335	COG4638	Rieske (2fe-2S)
E3Z24_RS06340	COG0583	DNA-binding transcription factor activity
E3Z24_RS06345	COG2814	Major facilitator Superfamily
E3Z24_RS06350	COG3711	transcriptional antiterminator
E3Z24_RS06355	COG1073	alpha beta
E3Z24_RS06360	COG0483	inositol monophosphate 1-phosphatase activity
E3Z24_RS06380	COG0822	iron-sulfur transferase activity
E3Z24_RS06400	COG0633	Ferredoxin
E3Z24_RS06405	COG2975	iron-sulfur cluster assembly
E3Z24_RS06420	COG2897	thiosulfate sulfurtransferase activity
E3Z24_RS06425	COG2373	Large extracellular alpha-helical protein
E3Z24_RS06430	COG4953	penicillin-binding protein 1C
E3Z24_RS06460	COG2976	Protein conserved in bacteria
E3Z24_RS06475	COG1645	bacterial-type flagellum-dependent swarming motility
E3Z24_RS06485	COG0517	IMP dehydrogenase activity
E3Z24_RS06485	COG0516	GMP reductase activity
E3Z24_RS06500	COG3133	Outer membrane lipoprotein
E3Z24_RS06510	COG2200	EAL domain
E3Z24_RS06515	COG0248	Ppx GppA phosphatase
E3Z24_RS06520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3Z24_RS06525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3Z24_RS06540	COG2233	PERMEase
E3Z24_RS06550	COG1393	Belongs to the ArsC family
E3Z24_RS06555	COG4783	chaperone-mediated protein folding
E3Z24_RS06560	COG0628	permease
E3Z24_RS06565	COG2116	formate transmembrane transporter activity
E3Z24_RS06570	COG3604	Transcriptional regulator
E3Z24_RS06580	COG3260	NADH ubiquinone oxidoreductase 20
E3Z24_RS06585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z24_RS06590	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3Z24_RS06590	COG3261	NADH dehydrogenase
E3Z24_RS06595	COG0651	ATP synthesis coupled electron transport
E3Z24_RS06600	COG4237	Hydrogenase 4 membrane
E3Z24_RS06605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3Z24_RS06610	COG0650	Formate hydrogenlyase subunit 4
E3Z24_RS06615	COG0651	ATP synthesis coupled electron transport
E3Z24_RS06620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS06625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3Z24_RS06630	COG2716	regulation of RNA biosynthetic process
E3Z24_RS06640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3Z24_RS06650	COG2321	neutral zinc metallopeptidase
E3Z24_RS06655	COG1444	tRNA N-acetyltransferase activity
E3Z24_RS06660	COG0400	carboxylic ester hydrolase activity
E3Z24_RS06675	COG1393	Belongs to the ArsC family
E3Z24_RS06685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3Z24_RS06690	COG3850	Histidine kinase
E3Z24_RS06695	COG0493	'glutamate synthase
E3Z24_RS06695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS06705	COG5342	invasion associated locus B
E3Z24_RS06710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3Z24_RS06715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3Z24_RS06720	COG0281	malic enzyme
E3Z24_RS06720	COG0280	phosphate acetyltransferase
E3Z24_RS06725	COG4810	utilization protein
E3Z24_RS06730	COG4917	ethanolamine utilization protein
E3Z24_RS06735	COG4766	ethanolamine catabolic process
E3Z24_RS06740	COG4812	Cobalamin adenosyltransferase
E3Z24_RS06745	COG0280	phosphate acetyltransferase
E3Z24_RS06750	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E3Z24_RS06755	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E3Z24_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS06765	COG4820	ethanolamine utilization protein (EutJ)
E3Z24_RS06770	COG1454	alcohol dehydrogenase
E3Z24_RS06775	COG3192	ethanolamine utilization protein
E3Z24_RS06780	COG4819	ethanolamine utilization protein
E3Z24_RS06785	COG4303	Ethanolamine ammonia lyase large subunit
E3Z24_RS06795	COG4816	utilization protein
E3Z24_RS06800	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E3Z24_RS06805	COG2207	Transcriptional regulator
E3Z24_RS06815	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3Z24_RS06820	COG0456	acetyltransferase
E3Z24_RS06835	COG2837	iron assimilation
E3Z24_RS06840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3Z24_RS06845	COG1263	PTS System
E3Z24_RS06845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS06865	COG4150	thiosulfate binding
E3Z24_RS06870	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3Z24_RS06875	COG4208	sulfate ABC transporter
E3Z24_RS06880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3Z24_RS06885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3Z24_RS06890	COG4884	unkown
E3Z24_RS06890	COG3831	ATPase activity
E3Z24_RS06905	COG2190	(PTS) system
E3Z24_RS06910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z24_RS06915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS06920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3Z24_RS06940	COG3530	Putative quorum-sensing-regulated virulence factor
E3Z24_RS06945	COG0385	Bile acid
E3Z24_RS06950	COG0583	DNA-binding transcription factor activity
E3Z24_RS06960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3Z24_RS06965	COG2211	Major facilitator Superfamily
E3Z24_RS06975	COG0583	DNA-binding transcription factor activity
E3Z24_RS07005	COG3415	Transposase
E3Z24_RS07010	COG3415	Transposase
E3Z24_RS07025	COG2200	EAL domain
E3Z24_RS07025	COG2199	diguanylate cyclase activity
E3Z24_RS07030	COG3385	transposase activity
E3Z24_RS07035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3Z24_RS07060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS07065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS07070	COG0006	proline dipeptidase activity
E3Z24_RS07075	COG1363	Peptidase, m42
E3Z24_RS07080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS07080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS07080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z24_RS07090	COG3279	Response regulator of the LytR AlgR family
E3Z24_RS07095	COG3275	phosphorelay sensor kinase activity
E3Z24_RS07100	COG0436	Aminotransferase
E3Z24_RS07110	COG1560	Kdo2-lipid A biosynthetic process
E3Z24_RS07135	COG0028	Belongs to the TPP enzyme family
E3Z24_RS07140	COG0679	Auxin Efflux Carrier
E3Z24_RS07145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3Z24_RS07150	COG0784	Response regulator, receiver
E3Z24_RS07150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS07150	COG2198	Histidine kinase
E3Z24_RS07150	COG2205	protein histidine kinase activity
E3Z24_RS07155	COG2197	response regulator
E3Z24_RS07160	COG1566	PFAM secretion protein HlyD family protein
E3Z24_RS07165	COG0477	Major facilitator Superfamily
E3Z24_RS07205	COG2116	formate transmembrane transporter activity
E3Z24_RS07210	COG2853	Lipoprotein
E3Z24_RS07220	COG3547	Transposase (IS116 IS110 IS902 family)
E3Z24_RS07225	COG2067	long-chain fatty acid transport protein
E3Z24_RS07230	COG3691	Protein conserved in bacteria
E3Z24_RS07245	COG2062	phosphohistidine phosphatase, SixA
E3Z24_RS07250	COG3539	Fimbrial protein
E3Z24_RS07255	COG3188	usher protein
E3Z24_RS07260	COG3121	Chaperone
E3Z24_RS07265	COG3539	Fimbrial protein
E3Z24_RS07270	COG3539	Fimbrial protein
E3Z24_RS07275	COG3539	Fimbrial protein
E3Z24_RS07290	COG2890	protein-(glutamine-N5) methyltransferase activity
E3Z24_RS07305	COG0730	response to heat
E3Z24_RS07310	COG3101	peptidyl-lysine hydroxylation
E3Z24_RS07325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3Z24_RS07330	COG2814	Major facilitator Superfamily
E3Z24_RS07345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3Z24_RS07355	COG0586	Pfam SNARE associated Golgi protein
E3Z24_RS07365	COG0285	dihydrofolate synthase activity
E3Z24_RS07370	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E3Z24_RS07375	COG1286	toxin biosynthetic process
E3Z24_RS07380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3Z24_RS07385	COG0163	prenyltransferase activity
E3Z24_RS07390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS07400	COG4215	(ABC) transporter
E3Z24_RS07405	COG4160	amino acid transport
E3Z24_RS07410	COG4598	ABC transporter
E3Z24_RS07415	COG5464	transposase or invertase
E3Z24_RS07420	COG1090	epimerase
E3Z24_RS07425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3Z24_RS07430	COG0625	glutathione transferase activity
E3Z24_RS07435	COG0625	glutathione transferase activity
E3Z24_RS07440	COG0622	Phosphoesterase
E3Z24_RS07445	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E3Z24_RS07450	COG1288	antiporter activity
E3Z24_RS07455	COG0280	phosphate acetyltransferase
E3Z24_RS07455	COG0857	belongs to the CobB CobQ family
E3Z24_RS07460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3Z24_RS07475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z24_RS07480	COG0490	domain, Protein
E3Z24_RS07480	COG0471	metal ion transport
E3Z24_RS07490	COG0436	Aminotransferase
E3Z24_RS07495	COG0583	DNA-binding transcription factor activity
E3Z24_RS07515	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E3Z24_RS07520	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3Z24_RS07525	COG1034	ATP synthesis coupled electron transport
E3Z24_RS07540	COG0839	Belongs to the complex I subunit 6 family
E3Z24_RS07550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3Z24_RS07555	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z24_RS07565	COG0457	Tetratricopeptide repeat
E3Z24_RS07585	COG2234	aminopeptidase activity
E3Z24_RS07590	COG2304	oxidoreductase activity
E3Z24_RS07595	COG5160	protein modification by small protein removal
E3Z24_RS07605	COG2153	protein acetylation
E3Z24_RS07610	COG4575	ribosome binding
E3Z24_RS07615	COG1169	isochorismate synthase
E3Z24_RS07630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3Z24_RS07640	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z24_RS07715	COG2271	Major facilitator Superfamily
E3Z24_RS07730	COG5464	transposase or invertase
E3Z24_RS07735	COG0247	lactate metabolic process
E3Z24_RS07745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3Z24_RS07750	COG2271	Major facilitator Superfamily
E3Z24_RS07755	COG0584	glycerophosphoryl diester phosphodiesterase
E3Z24_RS07765	COG3642	lipopolysaccharide core region biosynthetic process
E3Z24_RS07770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z24_RS07775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3Z24_RS07780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3Z24_RS07785	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS07795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3Z24_RS07800	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E3Z24_RS07805	COG3234	Protein of unknown function (DUF1175)
E3Z24_RS07810	COG2373	Large extracellular alpha-helical protein
E3Z24_RS07815	COG5445	Predicted secreted protein (DUF2300)
E3Z24_RS07820	COG4676	Protein conserved in bacteria
E3Z24_RS07825	COG0183	Belongs to the thiolase family
E3Z24_RS07830	COG2031	fatty acid transporter
E3Z24_RS07835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3Z24_RS07840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3Z24_RS07845	COG2204	response regulator
E3Z24_RS07850	COG3852	Histidine kinase
E3Z24_RS07855	COG2205	protein histidine kinase activity
E3Z24_RS07855	COG0784	Response regulator, receiver
E3Z24_RS07860	COG2197	response regulator
E3Z24_RS07865	COG0642	Histidine kinase
E3Z24_RS07865	COG2198	Histidine kinase
E3Z24_RS07870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3Z24_RS07875	COG1477	protein flavinylation
E3Z24_RS07880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3Z24_RS07880	COG2169	Transcriptional regulator
E3Z24_RS07885	COG3145	DNA-N1-methyladenine dioxygenase activity
E3Z24_RS07890	COG4615	Cyclic peptide transporter
E3Z24_RS07905	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS07905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z24_RS07910	COG3062	negative regulation of establishment of protein localization
E3Z24_RS07920	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS07925	COG0348	domain, Protein
E3Z24_RS07930	COG3043	anaerobic respiration
E3Z24_RS07935	COG3005	denitrification pathway
E3Z24_RS07940	COG4133	protoheme IX ABC transporter activity
E3Z24_RS07945	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3Z24_RS07950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3Z24_RS07955	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3Z24_RS07965	COG1138	Cytochrome C-type biogenesis protein
E3Z24_RS07970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3Z24_RS07975	COG3088	subunit of a heme lyase
E3Z24_RS07975	COG4235	cytochrome complex assembly
E3Z24_RS07980	COG2197	response regulator
E3Z24_RS07985	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS07995	COG3083	sulfuric ester hydrolase activity
E3Z24_RS08015	COG1061	Type III restriction enzyme res subunit
E3Z24_RS08020	COG1187	pseudouridine synthase activity
E3Z24_RS08025	COG2814	Major facilitator Superfamily
E3Z24_RS08035	COG4172	Belongs to the ABC transporter superfamily
E3Z24_RS08040	COG4239	(ABC) transporter, permease
E3Z24_RS08045	COG4174	ABC transporter (Permease)
E3Z24_RS08050	COG4166	transmembrane transport
E3Z24_RS08055	COG2200	EAL domain
E3Z24_RS08060	COG0791	NLP P60 protein
E3Z24_RS08065	COG0671	phosphoesterase, PA-phosphatase related
E3Z24_RS08070	COG0523	cobalamin synthesis protein
E3Z24_RS08075	COG0246	Mannitol dehydrogenase
E3Z24_RS08090	COG2814	Major facilitator Superfamily
E3Z24_RS08095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS08095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS08100	COG1105	Belongs to the carbohydrate kinase PfkB family
E3Z24_RS08105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS08105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS08105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E3Z24_RS08110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS08115	COG2313	pseudouridylate synthase activity
E3Z24_RS08120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3Z24_RS08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z24_RS08135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3Z24_RS08140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS08140	COG1522	sequence-specific DNA binding
E3Z24_RS08150	COG2855	membrane
E3Z24_RS08155	COG0583	DNA-binding transcription factor activity
E3Z24_RS08160	COG0833	amino acid
E3Z24_RS08180	COG2311	Membrane
E3Z24_RS08185	COG1609	Transcriptional regulator
E3Z24_RS08190	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS08195	COG1129	ABC transporter
E3Z24_RS08200	COG4211	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS08205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3Z24_RS08205	COG0167	dihydroorotate dehydrogenase activity
E3Z24_RS08210	COG0493	'glutamate synthase
E3Z24_RS08220	COG2949	membrane
E3Z24_RS08230	COG1346	cytolysis
E3Z24_RS08240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3Z24_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS08260	COG0586	Pfam SNARE associated Golgi protein
E3Z24_RS08270	COG1686	Belongs to the peptidase S11 family
E3Z24_RS08275	COG0277	FAD linked oxidase domain protein
E3Z24_RS08280	COG1472	Belongs to the glycosyl hydrolase 3 family
E3Z24_RS08285	COG1732	Glycine betaine
E3Z24_RS08290	COG1174	glycine betaine transport
E3Z24_RS08295	COG1125	glycine betaine transport
E3Z24_RS08300	COG1174	glycine betaine transport
E3Z24_RS08310	COG0789	Transcriptional regulator
E3Z24_RS08315	COG3275	phosphorelay sensor kinase activity
E3Z24_RS08320	COG3279	Response regulator of the LytR AlgR family
E3Z24_RS08325	COG4807	Protein conserved in bacteria
E3Z24_RS08330	COG4808	Protein conserved in bacteria
E3Z24_RS08335	COG4715	Zinc finger, swim domain protein
E3Z24_RS08340	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E3Z24_RS08360	COG3831	ATPase activity
E3Z24_RS08365	COG3831	ATPase activity
E3Z24_RS08370	COG3831	ATPase activity
E3Z24_RS08380	COG0489	protein tyrosine kinase activity
E3Z24_RS08390	COG3539	Fimbrial protein
E3Z24_RS08395	COG3121	Chaperone
E3Z24_RS08400	COG3188	usher protein
E3Z24_RS08405	COG3539	Fimbrial protein
E3Z24_RS08410	COG5455	response to cobalt ion
E3Z24_RS08430	COG0351	phosphomethylpyrimidine kinase
E3Z24_RS08435	COG3757	hydrolase, family 25
E3Z24_RS08440	COG2188	Transcriptional regulator
E3Z24_RS08445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS08450	COG1397	ADP-ribosylglycohydrolase
E3Z24_RS08455	COG2211	Major facilitator Superfamily
E3Z24_RS08460	COG1830	Aldolase
E3Z24_RS08475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS08480	COG3414	Phosphotransferase system galactitol-specific IIB component
E3Z24_RS08485	COG3775	system Galactitol-specific IIC component
E3Z24_RS08490	COG1063	alcohol dehydrogenase
E3Z24_RS08515	COG0826	peptidase U32
E3Z24_RS08525	COG3609	addiction module antidote protein, CC2985 family
E3Z24_RS08535	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS08540	COG2205	protein histidine kinase activity
E3Z24_RS08580	COG4245	von Willebrand factor, type A
E3Z24_RS08585	COG0631	protein serine/threonine phosphatase activity
E3Z24_RS08595	COG0443	Heat shock 70 kDa protein
E3Z24_RS08600	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E3Z24_RS08605	COG3447	MASE1 domain protein
E3Z24_RS08605	COG5001	Diguanylate cyclase
E3Z24_RS08605	COG5002	protein histidine kinase activity
E3Z24_RS08610	COG0572	uridine kinase
E3Z24_RS08620	COG2982	Protein involved in outer membrane biogenesis
E3Z24_RS08635	COG1253	flavin adenine dinucleotide binding
E3Z24_RS08695	COG0438	transferase activity, transferring glycosyl groups
E3Z24_RS08710	COG0110	maltose O-acetyltransferase activity
E3Z24_RS08720	COG1088	dTDP-glucose 4,6-dehydratase activity
E3Z24_RS08770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3Z24_RS08780	COG0438	transferase activity, transferring glycosyl groups
E3Z24_RS08790	COG0140	phosphoribosyl-ATP diphosphatase activity
E3Z24_RS08790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3Z24_RS08805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3Z24_RS08810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3Z24_RS08810	COG0131	Imidazoleglycerol-phosphate dehydratase
E3Z24_RS08835	COG2161	toxin-antitoxin pair type II binding
E3Z24_RS08840	COG4115	mRNA cleavage
E3Z24_RS08845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3Z24_RS08850	COG0583	DNA-binding transcription factor activity
E3Z24_RS08860	COG0531	amino acid
E3Z24_RS08865	COG2391	methyltransferase activity
E3Z24_RS08870	COG0425	Belongs to the sulfur carrier protein TusA family
E3Z24_RS08875	COG2925	Exonuclease
E3Z24_RS08880	COG1686	Belongs to the peptidase S11 family
E3Z24_RS08890	COG1289	transmembrane transporter activity
E3Z24_RS08900	COG4917	ethanolamine utilization protein
E3Z24_RS08940	COG2003	Belongs to the UPF0758 family
E3Z24_RS08945	COG1484	DNA-dependent DNA replication
E3Z24_RS08950	COG4584	PFAM Integrase catalytic
E3Z24_RS08955	COG2003	Belongs to the UPF0758 family
E3Z24_RS08985	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS09075	COG1735	metal-dependent hydrolase with the TIM-barrel fold
E3Z24_RS09090	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E3Z24_RS09105	COG1376	ErfK ybiS ycfS ynhG family protein
E3Z24_RS09115	COG0583	DNA-binding transcription factor activity
E3Z24_RS09130	COG0534	Mate efflux family protein
E3Z24_RS09140	COG0217	transcriptional regulatory protein
E3Z24_RS09145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3Z24_RS09150	COG0477	Major facilitator Superfamily
E3Z24_RS09170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3Z24_RS09335	COG4771	TonB-dependent receptor
E3Z24_RS09340	COG1021	2,3-dihydroxybenzoate-AMP ligase
E3Z24_RS09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z24_RS09360	COG2226	methyltransferase
E3Z24_RS09360	COG3433	isochorismatase activity
E3Z24_RS09375	COG1132	(ABC) transporter
E3Z24_RS09380	COG2814	Major facilitator Superfamily
E3Z24_RS09385	COG1169	isochorismate synthase
E3Z24_RS09390	COG0582	viral genome integration into host DNA
E3Z24_RS09410	COG3038	cytochrome b561
E3Z24_RS09415	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3Z24_RS09430	COG2351	hydroxyisourate hydrolase activity
E3Z24_RS09435	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS09440	COG2205	protein histidine kinase activity
E3Z24_RS09455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3Z24_RS09465	COG1418	mRNA catabolic process
E3Z24_RS09470	COG0270	DNA (cytosine-5-)-methyltransferase activity
E3Z24_RS09475	COG3727	T/G mismatch-specific endonuclease activity
E3Z24_RS09480	COG0697	spore germination
E3Z24_RS09485	COG2354	Protein conserved in bacteria
E3Z24_RS09490	COG5475	Uncharacterized small protein (DUF2158)
E3Z24_RS09515	COG2197	response regulator
E3Z24_RS09520	COG1684	flagellar biosynthetic protein fliR
E3Z24_RS09525	COG1987	bacterial-type flagellum assembly
E3Z24_RS09530	COG1338	Plays a role in the flagellum-specific transport system
E3Z24_RS09535	COG3190	flagellar
E3Z24_RS09540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3Z24_RS09545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3Z24_RS09550	COG1580	Controls the rotational direction of flagella during chemotaxis
E3Z24_RS09555	COG3144	bacterial-type flagellum assembly
E3Z24_RS09560	COG2882	bacterial-type flagellum organization
E3Z24_RS09570	COG1317	bacterial-type flagellum organization
E3Z24_RS09575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3Z24_RS09580	COG1766	The M ring may be actively involved in energy transduction
E3Z24_RS09605	COG2135	peptidase activity
E3Z24_RS09610	COG0425	Belongs to the sulfur carrier protein TusA family
E3Z24_RS09615	COG2391	methyltransferase activity
E3Z24_RS09625	COG0366	Alpha amylase catalytic
E3Z24_RS09635	COG1516	flagellar protein fliS
E3Z24_RS09640	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E3Z24_RS09650	COG1191	sigma factor activity
E3Z24_RS09660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS09670	COG0765	amino acid transport
E3Z24_RS09675	COG1126	abc transporter atp-binding protein
E3Z24_RS09680	COG2197	response regulator
E3Z24_RS09730	COG3318	Belongs to the UPF0149 family
E3Z24_RS09730	COG3012	SEC-C Motif Domain Protein
E3Z24_RS09735	COG0814	amino acid
E3Z24_RS09745	COG1528	Iron-storage protein
E3Z24_RS09765	COG1528	Iron-storage protein
E3Z24_RS09770	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS09775	COG1129	ABC transporter
E3Z24_RS09780	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS09785	COG1877	trehalose-phosphatase activity
E3Z24_RS09795	COG0589	response to stress
E3Z24_RS09810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3Z24_RS09815	COG1360	Flagellar Motor Protein
E3Z24_RS09820	COG0643	Histidine kinase
E3Z24_RS09820	COG2198	Histidine kinase
E3Z24_RS09825	COG0835	chemotaxis
E3Z24_RS09830	COG0840	transmembrane signaling receptor activity
E3Z24_RS09835	COG0840	transmembrane signaling receptor activity
E3Z24_RS09840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3Z24_RS09845	COG2201	protein-glutamate methylesterase activity
E3Z24_RS09850	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS09855	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E3Z24_RS09860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3Z24_RS09865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3Z24_RS09875	COG3755	Protein conserved in bacteria
E3Z24_RS09885	COG3102	Protein conserved in bacteria
E3Z24_RS09895	COG3005	denitrification pathway
E3Z24_RS09900	COG0243	molybdopterin cofactor binding
E3Z24_RS09915	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E3Z24_RS09920	COG1801	Protein of unknown function DUF72
E3Z24_RS09925	COG1335	isochorismatase
E3Z24_RS09935	COG0494	nUDIX hydrolase
E3Z24_RS09940	COG0217	transcriptional regulatory protein
E3Z24_RS09970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3Z24_RS09980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E3Z24_RS09985	COG0739	heme binding
E3Z24_RS09990	COG1560	Kdo2-lipid A biosynthetic process
E3Z24_RS09995	COG0469	pyruvate kinase activity
E3Z24_RS10000	COG1737	Transcriptional regulator
E3Z24_RS10005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3Z24_RS10010	COG0129	dihydroxy-acid dehydratase activity
E3Z24_RS10015	COG0800	Aldolase
E3Z24_RS10025	COG3141	response to X-ray
E3Z24_RS10035	COG2979	Protein of unknown function (DUF533)
E3Z24_RS10040	COG1770	oligopeptidase
E3Z24_RS10045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z24_RS10050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3Z24_RS10060	COG2372	response to copper ion
E3Z24_RS10065	COG1276	copper resistance
E3Z24_RS10075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3Z24_RS10095	COG3008	intermembrane lipid transfer
E3Z24_RS10100	COG2995	paraquat-inducible protein a
E3Z24_RS10105	COG1956	GAF domain-containing protein
E3Z24_RS10115	COG0793	Belongs to the peptidase S41A family
E3Z24_RS10125	COG2814	Major facilitator Superfamily
E3Z24_RS10130	COG1414	Transcriptional regulator
E3Z24_RS10160	COG2226	methyltransferase
E3Z24_RS10175	COG3716	PTS system mannose fructose sorbose family IID component
E3Z24_RS10180	COG3715	PTS system
E3Z24_RS10185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS10185	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS10190	COG1253	flavin adenine dinucleotide binding
E3Z24_RS10195	COG2200	EAL domain
E3Z24_RS10200	COG1760	l-serine dehydratase
E3Z24_RS10210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3Z24_RS10225	COG0251	oxidation-reduction process
E3Z24_RS10230	COG1199	ATP-dependent helicase activity
E3Z24_RS10235	COG1214	PFAM Peptidase M22, glycoprotease
E3Z24_RS10240	COG3065	identical protein binding
E3Z24_RS10245	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z24_RS10250	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3Z24_RS10255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z24_RS10260	COG4638	Rieske (2fe-2S)
E3Z24_RS10265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3Z24_RS10270	COG0473	3-isopropylmalate dehydrogenase activity
E3Z24_RS10275	COG0583	DNA-binding transcription factor activity
E3Z24_RS10285	COG3615	Tellurite resistance protein tehB
E3Z24_RS10295	COG2261	transglycosylase associated protein
E3Z24_RS10310	COG2199	diguanylate cyclase activity
E3Z24_RS10310	COG2203	Gaf domain
E3Z24_RS10315	COG3042	response to heat
E3Z24_RS10320	COG3189	MarR family transcriptional regulator
E3Z24_RS10325	COG2807	transmembrane transport
E3Z24_RS10330	COG2207	Transcriptional regulator
E3Z24_RS10345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3Z24_RS10350	COG2199	diguanylate cyclase activity
E3Z24_RS10355	COG2199	diguanylate cyclase activity
E3Z24_RS10365	COG2766	serine protein kinase
E3Z24_RS10370	COG3713	MltA-interacting MipA family protein
E3Z24_RS10375	COG0656	L-ascorbic acid biosynthetic process
E3Z24_RS10380	COG0676	glucose-6-phosphate 1-epimerase activity
E3Z24_RS10385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3Z24_RS10395	COG3139	Protein of unknown function (DUF1315)
E3Z24_RS10400	COG1063	alcohol dehydrogenase
E3Z24_RS10405	COG2271	Major facilitator Superfamily
E3Z24_RS10410	COG1063	alcohol dehydrogenase
E3Z24_RS10415	COG0191	fructose-bisphosphate aldolase activity
E3Z24_RS10420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS10425	COG0667	Aldo Keto reductase
E3Z24_RS10430	COG1349	DNA-binding transcription factor activity
E3Z24_RS10435	COG2814	Major facilitator Superfamily
E3Z24_RS10440	COG1335	isochorismatase
E3Z24_RS10445	COG0252	asparaginase activity
E3Z24_RS10450	COG0616	signal peptide processing
E3Z24_RS10455	COG0778	Nitroreductase
E3Z24_RS10465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3Z24_RS10475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3Z24_RS10485	COG0494	nUDIX hydrolase
E3Z24_RS10490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3Z24_RS10495	COG2897	thiosulfate sulfurtransferase activity
E3Z24_RS10500	COG4136	ATPase activity
E3Z24_RS10505	COG4135	transport system, permease component
E3Z24_RS10510	COG4134	Bacterial extracellular solute-binding protein
E3Z24_RS10515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z24_RS10520	COG0398	Pfam SNARE associated Golgi protein
E3Z24_RS10530	COG0398	Pfam SNARE associated Golgi protein
E3Z24_RS10535	COG0708	Exodeoxyribonuclease III
E3Z24_RS10565	COG3678	ATP-independent chaperone mediated protein folding
E3Z24_RS10575	COG0322	excinuclease ABC activity
E3Z24_RS10585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z24_RS10590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3Z24_RS10595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3Z24_RS10600	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3Z24_RS10605	COG1917	Cupin 2, conserved barrel domain protein
E3Z24_RS10605	COG2169	Transcriptional regulator
E3Z24_RS10610	COG1486	melibiose metabolic process
E3Z24_RS10620	COG0753	catalase activity
E3Z24_RS10635	COG1823	symporter activity
E3Z24_RS10640	COG1988	membrane-bound metal-dependent
E3Z24_RS10645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z24_RS10655	COG3001	Fructosamine kinase
E3Z24_RS10665	COG1105	Belongs to the carbohydrate kinase PfkB family
E3Z24_RS10670	COG3137	Salt-induced outer membrane protein
E3Z24_RS10715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3Z24_RS10715	COG0072	phenylalanine-tRNA ligase activity
E3Z24_RS10730	COG0386	Belongs to the glutathione peroxidase family
E3Z24_RS10740	COG0791	NLP P60 protein
E3Z24_RS10745	COG2200	EAL domain
E3Z24_RS10755	COG4256	Hemin uptake protein
E3Z24_RS10760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3Z24_RS10770	COG0574	Belongs to the PEP-utilizing enzyme family
E3Z24_RS10770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z24_RS10775	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z24_RS10780	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3Z24_RS10785	COG0644	oxidoreductase
E3Z24_RS10790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3Z24_RS10795	COG2086	electron transfer activity
E3Z24_RS10800	COG1917	Cupin 2, conserved barrel domain protein
E3Z24_RS10800	COG2207	Transcriptional regulator
E3Z24_RS10805	COG1960	acyl-CoA dehydrogenase activity
E3Z24_RS10810	COG4670	ketone body catabolic process
E3Z24_RS10825	COG2271	Major facilitator Superfamily
E3Z24_RS10830	COG0738	Major facilitator superfamily
E3Z24_RS10845	COG0628	permease
E3Z24_RS10850	COG0277	FAD linked oxidase domain protein
E3Z24_RS10850	COG0247	lactate metabolic process
E3Z24_RS10855	COG2050	protein possibly involved in aromatic compounds catabolism
E3Z24_RS10865	COG0316	Belongs to the HesB IscA family
E3Z24_RS10870	COG0719	Fe-S assembly protein
E3Z24_RS10875	COG0396	ATPase activity
E3Z24_RS10880	COG0719	Fe-S assembly protein
E3Z24_RS10895	COG1376	ErfK ybiS ycfS ynhG family protein
E3Z24_RS10900	COG4238	major outer membrane lipoprotein
E3Z24_RS10905	COG0469	pyruvate kinase activity
E3Z24_RS10915	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS10920	COG2414	aldehyde ferredoxin oxidoreductase
E3Z24_RS10930	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS10935	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E3Z24_RS10945	COG4529	Protein conserved in bacteria
E3Z24_RS10965	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS10975	COG0307	riboflavin synthase, alpha
E3Z24_RS10980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3Z24_RS10985	COG2814	Major facilitator Superfamily
E3Z24_RS10990	COG0583	DNA-binding transcription factor activity
E3Z24_RS11005	COG2814	Major facilitator Superfamily
E3Z24_RS11010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3Z24_RS11015	COG0791	NLP P60 protein
E3Z24_RS11020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3Z24_RS11025	COG1201	RNA secondary structure unwinding
E3Z24_RS11030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z24_RS11035	COG0346	lactoylglutathione lyase activity
E3Z24_RS11040	COG1902	pentaerythritol trinitrate reductase activity
E3Z24_RS11045	COG1309	transcriptional regulator
E3Z24_RS11050	COG3313	Fe-S protein
E3Z24_RS11055	COG4989	oxidoreductase activity
E3Z24_RS11060	COG2032	superoxide dismutase activity
E3Z24_RS11065	COG1289	transmembrane transporter activity
E3Z24_RS11070	COG1566	PFAM secretion protein HlyD family protein
E3Z24_RS11085	COG3133	Outer membrane lipoprotein
E3Z24_RS11095	COG3895	Periplasmic Protein
E3Z24_RS11110	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3Z24_RS11115	COG0625	glutathione transferase activity
E3Z24_RS11120	COG3104	oligopeptide transport
E3Z24_RS11125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3Z24_RS11135	COG4659	FMN binding
E3Z24_RS11175	COG0673	inositol 2-dehydrogenase activity
E3Z24_RS11185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3Z24_RS11190	COG1263	PTS System
E3Z24_RS11190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS11195	COG1609	Transcriptional regulator
E3Z24_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS11205	COG1309	transcriptional regulator
E3Z24_RS11210	COG3250	beta-galactosidase activity
E3Z24_RS11225	COG5339	Protein conserved in bacteria
E3Z24_RS11230	COG1482	cell wall glycoprotein biosynthetic process
E3Z24_RS11235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3Z24_RS11235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3Z24_RS11240	COG0114	fumarate hydratase activity
E3Z24_RS11250	COG2205	protein histidine kinase activity
E3Z24_RS11255	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS11260	COG3136	membrane protein required for alginate biosynthesis
E3Z24_RS11270	COG0531	amino acid
E3Z24_RS11280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3Z24_RS11285	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3Z24_RS11290	COG0628	permease
E3Z24_RS11310	COG3591	Belongs to the peptidase S1B family
E3Z24_RS11325	COG2814	Major facilitator Superfamily
E3Z24_RS11330	COG0583	DNA-binding transcription factor activity
E3Z24_RS11335	COG1940	carbohydrate kinase activity
E3Z24_RS11340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3Z24_RS11350	COG3381	protein complex oligomerization
E3Z24_RS11355	COG3302	dmso reductase anchor subunit
E3Z24_RS11360	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS11365	COG0243	molybdopterin cofactor binding
E3Z24_RS11370	COG0243	molybdopterin cofactor binding
E3Z24_RS11385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3Z24_RS11400	COG4948	Mandelate Racemase Muconate Lactonizing
E3Z24_RS11405	COG1063	alcohol dehydrogenase
E3Z24_RS11410	COG0477	Major facilitator Superfamily
E3Z24_RS11415	COG0246	Mannitol dehydrogenase
E3Z24_RS11425	COG1802	Transcriptional regulator
E3Z24_RS11430	COG4221	oxidoreductase activity
E3Z24_RS11435	COG0339	signal peptide processing
E3Z24_RS11440	COG1546	Belongs to the CinA family
E3Z24_RS11445	COG3111	PFAM Bacterial OB fold (BOF) protein
E3Z24_RS11450	COG3706	GGDEF domain
E3Z24_RS11460	COG2814	Major facilitator Superfamily
E3Z24_RS11465	COG0697	spore germination
E3Z24_RS11475	COG4977	sequence-specific DNA binding
E3Z24_RS11480	COG1846	Transcriptional regulator
E3Z24_RS11500	COG0583	DNA-binding transcription factor activity
E3Z24_RS11505	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS11510	COG2066	Belongs to the glutaminase family
E3Z24_RS11520	COG2199	diguanylate cyclase activity
E3Z24_RS11530	COG3781	membrane
E3Z24_RS11580	COG2911	Protein conserved in bacteria
E3Z24_RS11580	COG3210	domain, Protein
E3Z24_RS11585	COG1396	sequence-specific DNA binding
E3Z24_RS11590	COG3550	peptidyl-serine autophosphorylation
E3Z24_RS11605	COG3539	Fimbrial protein
E3Z24_RS11610	COG3539	Fimbrial protein
E3Z24_RS11615	COG3539	Fimbrial protein
E3Z24_RS11620	COG0243	molybdopterin cofactor binding
E3Z24_RS11630	COG2207	Transcriptional regulator
E3Z24_RS11635	COG3119	arylsulfatase activity
E3Z24_RS11640	COG0641	radical SAM
E3Z24_RS11650	COG4178	(ABC) transporter
E3Z24_RS11655	COG4771	TonB-dependent receptor
E3Z24_RS11660	COG0612	Peptidase, M16
E3Z24_RS11665	COG0076	glutamate decarboxylase activity
E3Z24_RS11670	COG0531	amino acid
E3Z24_RS11675	COG1649	PFAM Uncharacterised BCR, COG1649
E3Z24_RS11680	COG3706	GGDEF domain
E3Z24_RS11685	COG2200	EAL domain
E3Z24_RS11685	COG2199	diguanylate cyclase activity
E3Z24_RS11685	COG2202	Pas domain
E3Z24_RS11690	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E3Z24_RS11695	COG0747	negative chemotaxis
E3Z24_RS11700	COG0601	transmembrane transport
E3Z24_RS11705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z24_RS11710	COG0444	Belongs to the ABC transporter superfamily
E3Z24_RS11715	COG4608	Belongs to the ABC transporter superfamily
E3Z24_RS11720	COG1764	response to oxidative stress
E3Z24_RS11740	COG1064	alcohol dehydrogenase
E3Z24_RS11745	COG3093	addiction module antidote protein HigA
E3Z24_RS11750	COG2864	formate dehydrogenase
E3Z24_RS11755	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS11765	COG0697	spore germination
E3Z24_RS11770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3Z24_RS11780	COG4886	Leucine-rich repeat (LRR) protein
E3Z24_RS11785	COG2223	nitrite transmembrane transporter activity
E3Z24_RS11795	COG1140	nitrate reductase beta subunit
E3Z24_RS11800	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3Z24_RS11805	COG2181	nitrate reductase activity
E3Z24_RS11810	COG0384	phenazine biosynthesis protein PhzF
E3Z24_RS11815	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E3Z24_RS11820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3Z24_RS11830	COG5433	transposase activity
E3Z24_RS11850	COG3209	COG3209 Rhs family protein
E3Z24_RS11865	COG0625	glutathione transferase activity
E3Z24_RS11870	COG1113	amino acid transport
E3Z24_RS11875	COG3391	amine dehydrogenase activity
E3Z24_RS11880	COG4772	TonB-dependent receptor
E3Z24_RS11885	COG1802	Transcriptional regulator
E3Z24_RS11890	COG2130	NADP-dependent
E3Z24_RS11895	COG1247	-acetyltransferase
E3Z24_RS11900	COG3238	Protein conserved in bacteria
E3Z24_RS11925	COG1177	transmembrane transport
E3Z24_RS11930	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z24_RS11935	COG3842	ATPase activity
E3Z24_RS11940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3Z24_RS11945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z24_RS11950	COG1598	PFAM Uncharacterised protein family UPF0150
E3Z24_RS11955	COG1724	mRNA binding
E3Z24_RS11965	COG0826	peptidase U32
E3Z24_RS11970	COG1396	sequence-specific DNA binding
E3Z24_RS11975	COG3135	benzoate transporter
E3Z24_RS11980	COG0675	Transposase, IS605 OrfB family
E3Z24_RS11995	COG0500	methyltransferase
E3Z24_RS12000	COG1275	C4-dicarboxylate transporter malic acid transport protein
E3Z24_RS12005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3Z24_RS12010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3Z24_RS12015	COG2841	Protein conserved in bacteria
E3Z24_RS12025	COG5383	Protein conserved in bacteria
E3Z24_RS12030	COG0583	DNA-binding transcription factor activity
E3Z24_RS12035	COG0840	transmembrane signaling receptor activity
E3Z24_RS12050	COG3038	cytochrome b561
E3Z24_RS12060	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS12065	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3Z24_RS12070	COG1643	Atp-dependent helicase
E3Z24_RS12080	COG2453	phosphatase
E3Z24_RS12080	COG0671	phosphoesterase, PA-phosphatase related
E3Z24_RS12085	COG2267	carboxylic ester hydrolase activity
E3Z24_RS12090	COG4589	Belongs to the CDS family
E3Z24_RS12095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3Z24_RS12105	COG0667	Aldo Keto reductase
E3Z24_RS12130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3Z24_RS12135	COG3327	negative regulation of DNA-templated transcription, initiation
E3Z24_RS12140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E3Z24_RS12145	COG0183	Belongs to the thiolase family
E3Z24_RS12150	COG2050	protein possibly involved in aromatic compounds catabolism
E3Z24_RS12155	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3Z24_RS12160	COG1024	Enoyl-CoA hydratase
E3Z24_RS12165	COG1024	Enoyl-CoA hydratase
E3Z24_RS12170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z24_RS12175	COG2151	metal-sulfur cluster biosynthetic enzyme
E3Z24_RS12180	COG3396	Phenylacetate-CoA oxygenase
E3Z24_RS12185	COG3460	Phenylacetate-CoA oxygenase
E3Z24_RS12190	COG3396	Phenylacetate-CoA oxygenase
E3Z24_RS12195	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS12195	COG2030	dehydratase
E3Z24_RS12200	COG3733	amine oxidase
E3Z24_RS12205	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS12210	COG2207	Transcriptional regulator
E3Z24_RS12215	COG3784	Protein of unknown function (DUF1318)
E3Z24_RS12225	COG2911	Protein conserved in bacteria
E3Z24_RS12230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3Z24_RS12235	COG3187	Heat shock protein
E3Z24_RS12240	COG3042	response to heat
E3Z24_RS12245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z24_RS12245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3Z24_RS12245	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3Z24_RS12245	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3Z24_RS12250	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3Z24_RS12255	COG0589	response to stress
E3Z24_RS12265	COG0513	Belongs to the DEAD box helicase family
E3Z24_RS12275	COG3706	GGDEF domain
E3Z24_RS12280	COG2840	Smr protein MutS2
E3Z24_RS12285	COG0583	DNA-binding transcription factor activity
E3Z24_RS12290	COG1473	amidohydrolase
E3Z24_RS12295	COG1473	amidohydrolase
E3Z24_RS12300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3Z24_RS12305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3Z24_RS12310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z24_RS12315	COG0589	response to stress
E3Z24_RS12320	COG3182	Iron-regulated membrane protein
E3Z24_RS12325	COG0668	transmembrane transport
E3Z24_RS12330	COG4166	transmembrane transport
E3Z24_RS12335	COG0583	DNA-binding transcription factor activity
E3Z24_RS12340	COG1073	alpha beta
E3Z24_RS12355	COG2866	Carboxypeptidase
E3Z24_RS12360	COG4948	Mandelate Racemase Muconate Lactonizing
E3Z24_RS12365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E3Z24_RS12370	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E3Z24_RS12380	COG3106	COG3106 Predicted ATPase
E3Z24_RS12385	COG1609	Transcriptional regulator
E3Z24_RS12395	COG3842	ATPase activity
E3Z24_RS12400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z24_RS12405	COG1554	hydrolase, family 65, central catalytic
E3Z24_RS12410	COG0673	inositol 2-dehydrogenase activity
E3Z24_RS12415	COG1082	Xylose isomerase domain protein TIM barrel
E3Z24_RS12420	COG1063	alcohol dehydrogenase
E3Z24_RS12425	COG0395	ABC-type sugar transport system, permease component
E3Z24_RS12430	COG1175	transmembrane transport
E3Z24_RS12440	COG0366	Alpha amylase catalytic
E3Z24_RS12445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3Z24_RS12455	COG1983	PspC domain protein
E3Z24_RS12465	COG1842	Phage shock protein A
E3Z24_RS12470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E3Z24_RS12475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z24_RS12480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z24_RS12485	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS12490	COG1396	sequence-specific DNA binding
E3Z24_RS12490	COG1917	Cupin 2, conserved barrel domain protein
E3Z24_RS12495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3Z24_RS12500	COG0174	glutamine synthetase
E3Z24_RS12510	COG0531	amino acid
E3Z24_RS12520	COG4166	transmembrane transport
E3Z24_RS12525	COG4168	peptide transport system, permease
E3Z24_RS12530	COG4171	peptide transport system, permease
E3Z24_RS12535	COG4172	Belongs to the ABC transporter superfamily
E3Z24_RS12540	COG4172	Belongs to the ABC transporter superfamily
E3Z24_RS12545	COG2852	Protein conserved in bacteria
E3Z24_RS12550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3Z24_RS12555	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z24_RS12555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z24_RS12570	COG5001	Diguanylate cyclase
E3Z24_RS12580	COG1349	DNA-binding transcription factor activity
E3Z24_RS12590	COG0023	Translation Initiation Factor
E3Z24_RS12600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E3Z24_RS12605	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E3Z24_RS12610	COG0671	phosphoesterase, PA-phosphatase related
E3Z24_RS12620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3Z24_RS12645	COG0583	DNA-binding transcription factor activity
E3Z24_RS12650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3Z24_RS12660	COG0616	signal peptide processing
E3Z24_RS12665	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS12670	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E3Z24_RS12675	COG1187	pseudouridine synthase activity
E3Z24_RS12680	COG4907	membrane protein (DUF2207)
E3Z24_RS12685	COG0009	L-threonylcarbamoyladenylate synthase
E3Z24_RS12690	COG0613	PHP domain protein
E3Z24_RS12700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3Z24_RS12705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3Z24_RS12705	COG0512	Glutamine amidotransferase of anthranilate synthase
E3Z24_RS12710	COG0135	phosphoribosylanthranilate isomerase activity
E3Z24_RS12710	COG0134	indole-3-glycerol-phosphate synthase activity
E3Z24_RS12725	COG3729	General stress protein
E3Z24_RS12730	COG3685	Protein conserved in bacteria
E3Z24_RS12735	COG3685	Protein conserved in bacteria
E3Z24_RS12740	COG3047	cAMP biosynthetic process
E3Z24_RS12760	COG1607	acyl-coa hydrolase
E3Z24_RS12765	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E3Z24_RS12770	COG2350	Protein conserved in bacteria
E3Z24_RS12775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3Z24_RS12795	COG4608	Belongs to the ABC transporter superfamily
E3Z24_RS12800	COG0444	Belongs to the ABC transporter superfamily
E3Z24_RS12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z24_RS12810	COG0601	transmembrane transport
E3Z24_RS12815	COG4166	transmembrane transport
E3Z24_RS12820	COG2095	MarC family integral membrane protein
E3Z24_RS12825	COG1454	alcohol dehydrogenase
E3Z24_RS12825	COG1012	belongs to the aldehyde dehydrogenase family
E3Z24_RS12835	COG1435	thymidine kinase activity
E3Z24_RS12845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3Z24_RS12850	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS12855	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3Z24_RS12865	COG0788	formyltetrahydrofolate deformylase activity
E3Z24_RS12900	COG2181	nitrate reductase activity
E3Z24_RS12905	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3Z24_RS12910	COG1140	nitrate reductase beta subunit
E3Z24_RS12915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3Z24_RS12920	COG2223	nitrite transmembrane transporter activity
E3Z24_RS12925	COG3850	Histidine kinase
E3Z24_RS12930	COG2197	response regulator
E3Z24_RS12935	COG4932	domain protein
E3Z24_RS12940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E3Z24_RS12945	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E3Z24_RS12950	COG4572	Cation transport regulator
E3Z24_RS12995	COG2912	Transglutaminase-like superfamily
E3Z24_RS13000	COG3094	Invasion gene expression up-regulator, SirB
E3Z24_RS13005	COG2890	protein-(glutamine-N5) methyltransferase activity
E3Z24_RS13030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3Z24_RS13035	COG0659	secondary active sulfate transmembrane transporter activity
E3Z24_RS13050	COG0012	GTP binding
E3Z24_RS13055	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS13060	COG3284	Transcriptional regulator
E3Z24_RS13065	COG2376	Dihydroxyacetone kinase
E3Z24_RS13070	COG1461	Dihydroxyacetone kinase
E3Z24_RS13075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z24_RS13075	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E3Z24_RS13075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS13090	COG2261	transglycosylase associated protein
E3Z24_RS13095	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E3Z24_RS13105	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3Z24_RS13115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3Z24_RS13125	COG2719	SpoVR family
E3Z24_RS13140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3Z24_RS13145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3Z24_RS13150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3Z24_RS13165	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3Z24_RS13190	COG2894	cell division
E3Z24_RS13240	COG2200	EAL domain
E3Z24_RS13265	COG2200	EAL domain
E3Z24_RS13270	COG0789	Transcriptional regulator
E3Z24_RS13275	COG5562	phage envelope protein
E3Z24_RS13290	COG0538	isocitrate dehydrogenase activity
E3Z24_RS13295	COG1187	pseudouridine synthase activity
E3Z24_RS13315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3Z24_RS13320	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS13325	COG2205	protein histidine kinase activity
E3Z24_RS13330	COG2850	peptidyl-arginine hydroxylation
E3Z24_RS13340	COG3842	ATPase activity
E3Z24_RS13355	COG0500	methyltransferase
E3Z24_RS13385	COG3344	reverse transcriptase
E3Z24_RS13520	COG3772	lysozyme
E3Z24_RS13560	COG0484	heat shock protein binding
E3Z24_RS13565	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3Z24_RS13570	COG1403	HNH endonuclease
E3Z24_RS13660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z24_RS13670	COG0582	viral genome integration into host DNA
E3Z24_RS13675	COG1177	transmembrane transport
E3Z24_RS13680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3Z24_RS13690	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3Z24_RS13695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3Z24_RS13705	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3Z24_RS13710	COG1136	(ABC) transporter
E3Z24_RS13715	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3Z24_RS13720	COG4763	Acyl-transferase
E3Z24_RS13725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3Z24_RS13730	COG1388	LysM domain
E3Z24_RS13730	COG1376	ErfK ybiS ycfS ynhG family protein
E3Z24_RS13740	COG1309	transcriptional regulator
E3Z24_RS13745	COG3134	Outer membrane lipoprotein
E3Z24_RS13750	COG1252	NADH dehydrogenase
E3Z24_RS13770	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E3Z24_RS13775	COG5633	Lipoprotein
E3Z24_RS13780	COG0537	adenosine 5'-monophosphoramidase activity
E3Z24_RS13785	COG4773	Receptor
E3Z24_RS13790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS13790	COG1263	PTS System
E3Z24_RS13795	COG0084	hydrolase, TatD family'
E3Z24_RS13800	COG0470	DNA polymerase III
E3Z24_RS13810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3Z24_RS13815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3Z24_RS13820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3Z24_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS13835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3Z24_RS13855	COG1399	metal-binding, possibly nucleic acid-binding protein
E3Z24_RS13860	COG0424	maF-like protein
E3Z24_RS13865	COG0564	pseudouridine synthase activity
E3Z24_RS13875	COG1530	ribonuclease E activity
E3Z24_RS13880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3Z24_RS13885	COG1256	bacterial-type flagellum assembly
E3Z24_RS13890	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3Z24_RS13890	COG3951	Flagellar rod assembly protein muramidase FlgJ
E3Z24_RS13905	COG4786	Flagellar basal body rod
E3Z24_RS13910	COG4787	bacterial-type flagellum-dependent cell motility
E3Z24_RS13915	COG1749	Flagellar hook protein flgE
E3Z24_RS13920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3Z24_RS13925	COG1558	bacterial-type flagellum-dependent cell motility
E3Z24_RS13930	COG1815	bacterial-type flagellum-dependent cell motility
E3Z24_RS13935	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E3Z24_RS13940	COG2747	anti-sigma28 factor FlgM
E3Z24_RS13945	COG3418	PFAM FlgN family protein
E3Z24_RS13950	COG0728	peptidoglycan biosynthetic process
E3Z24_RS13955	COG0673	inositol 2-dehydrogenase activity
E3Z24_RS13965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3Z24_RS13975	COG2999	glutathione oxidoreductase activity
E3Z24_RS14010	COG3038	cytochrome b561
E3Z24_RS14015	COG2353	YceI-like domain
E3Z24_RS14025	COG1560	Kdo2-lipid A biosynthetic process
E3Z24_RS14040	COG1484	DNA-dependent DNA replication
E3Z24_RS14045	COG4584	PFAM Integrase catalytic
E3Z24_RS14120	COG5645	(Lipo)protein
E3Z24_RS14125	COG2943	transferase activity, transferring hexosyl groups
E3Z24_RS14140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3Z24_RS14145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3Z24_RS14170	COG2197	response regulator
E3Z24_RS14185	COG1462	curli production assembly transport component CsgG
E3Z24_RS14195	COG3381	protein complex oligomerization
E3Z24_RS14235	COG3706	GGDEF domain
E3Z24_RS14240	COG0457	Tetratricopeptide repeat
E3Z24_RS14245	COG0726	polysaccharide deacetylase
E3Z24_RS14245	COG1649	PFAM Uncharacterised BCR, COG1649
E3Z24_RS14250	COG1215	transferase activity, transferring glycosyl groups
E3Z24_RS14255	COG3658	cytochrome
E3Z24_RS14260	COG1702	phosphate starvation-inducible protein PhoH
E3Z24_RS14265	COG2837	iron assimilation
E3Z24_RS14270	COG2822	iron ion transport
E3Z24_RS14280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3Z24_RS14290	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3Z24_RS14290	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3Z24_RS14290	COG0506	proline dehydrogenase activity
E3Z24_RS14295	COG1309	transcriptional regulator
E3Z24_RS14335	COG2233	PERMEase
E3Z24_RS14340	COG3729	General stress protein
E3Z24_RS14375	COG3381	protein complex oligomerization
E3Z24_RS14380	COG0243	molybdopterin cofactor binding
E3Z24_RS14385	COG3005	denitrification pathway
E3Z24_RS14390	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS14395	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS14400	COG2198	Histidine kinase
E3Z24_RS14400	COG2205	protein histidine kinase activity
E3Z24_RS14400	COG0784	Response regulator, receiver
E3Z24_RS14405	COG0348	domain, Protein
E3Z24_RS14425	COG1278	Cold shock
E3Z24_RS14430	COG1278	Cold shock
E3Z24_RS14450	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z24_RS14455	COG1596	polysaccharide export
E3Z24_RS14460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3Z24_RS14465	COG3206	protein involved in exopolysaccharide biosynthesis
E3Z24_RS14465	COG0489	protein tyrosine kinase activity
E3Z24_RS14480	COG1294	oxidase, subunit
E3Z24_RS14485	COG1271	oxidase subunit
E3Z24_RS14490	COG1773	rubredoxin
E3Z24_RS14495	COG1999	signal sequence binding
E3Z24_RS14500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3Z24_RS14505	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E3Z24_RS14510	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3Z24_RS14515	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3Z24_RS14525	COG0670	Belongs to the BI1 family
E3Z24_RS14530	COG2920	part of a sulfur-relay system
E3Z24_RS14535	COG1254	Belongs to the acylphosphatase family
E3Z24_RS14550	COG1832	CoA-binding protein
E3Z24_RS14565	COG0210	DNA helicase
E3Z24_RS14570	COG3304	Inner membrane component domain
E3Z24_RS14575	COG1289	transmembrane transporter activity
E3Z24_RS14580	COG3070	regulator of competence-specific genes
E3Z24_RS14590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3Z24_RS14590	COG2885	chlorophyll binding
E3Z24_RS14600	COG1067	ATP-dependent peptidase activity
E3Z24_RS14610	COG3130	regulation of translation
E3Z24_RS14615	COG3009	Protein conserved in bacteria
E3Z24_RS14620	COG3008	intermembrane lipid transfer
E3Z24_RS14620	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3Z24_RS14625	COG2995	paraquat-inducible protein a
E3Z24_RS14630	COG0488	(ABC) transporter
E3Z24_RS14640	COG0633	Ferredoxin
E3Z24_RS14640	COG3217	Mosc domain protein beta barrel domain protein
E3Z24_RS14655	COG3121	Chaperone
E3Z24_RS14660	COG3539	Fimbrial protein
E3Z24_RS14665	COG3539	Fimbrial protein
E3Z24_RS14670	COG3539	Fimbrial protein
E3Z24_RS14675	COG3188	usher protein
E3Z24_RS14680	COG3121	Chaperone
E3Z24_RS14685	COG3539	Fimbrial protein
E3Z24_RS14690	COG0431	NADPH-dependent FMN reductase
E3Z24_RS14695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3Z24_RS14705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3Z24_RS14710	COG1116	anion transmembrane transporter activity
E3Z24_RS14715	COG0308	aminopeptidase N
E3Z24_RS14735	COG1448	Aminotransferase
E3Z24_RS14740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3Z24_RS14745	COG3108	Peptidase M15
E3Z24_RS14750	COG2989	Protein conserved in bacteria
E3Z24_RS14760	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E3Z24_RS14770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3Z24_RS14775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3Z24_RS14780	COG3173	Aminoglycoside phosphotransferase
E3Z24_RS14795	COG3214	Protein conserved in bacteria
E3Z24_RS14800	COG1663	tetraacyldisaccharide 4'-kinase activity
E3Z24_RS14805	COG1132	(ABC) transporter
E3Z24_RS14810	COG2333	competence protein COMEC
E3Z24_RS14810	COG0658	competence protein
E3Z24_RS14820	COG0539	negative regulation of cytoplasmic translation
E3Z24_RS14830	COG0501	Belongs to the peptidase M48B family
E3Z24_RS14845	COG2323	membrane
E3Z24_RS14850	COG1944	ATP diphosphatase activity
E3Z24_RS14855	COG2116	formate transmembrane transporter activity
E3Z24_RS14860	COG1882	Formate acetyltransferase
E3Z24_RS14865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3Z24_RS14870	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3Z24_RS14875	COG0583	DNA-binding transcription factor activity
E3Z24_RS14880	COG0531	amino acid
E3Z24_RS14890	COG1335	isochorismatase
E3Z24_RS14895	COG3302	dmso reductase anchor subunit
E3Z24_RS14900	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS14905	COG0243	molybdopterin cofactor binding
E3Z24_RS14915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3Z24_RS14925	COG1178	ABC-type Fe3 transport system permease component
E3Z24_RS14925	COG1674	ftsk spoiiie
E3Z24_RS14930	COG1522	sequence-specific DNA binding
E3Z24_RS14935	COG0492	ferredoxin-NADP+ reductase activity
E3Z24_RS14940	COG4988	ABC transporter
E3Z24_RS14945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3Z24_RS14970	COG0542	response to heat
E3Z24_RS14980	COG1278	Cold shock
E3Z24_RS14985	COG1136	(ABC) transporter
E3Z24_RS14985	COG0577	efflux transmembrane transporter activity
E3Z24_RS14990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z24_RS14995	COG2990	Protein conserved in bacteria
E3Z24_RS15000	COG3593	DNA synthesis involved in DNA repair
E3Z24_RS15010	COG2431	L-lysine efflux transmembrane transporter activity
E3Z24_RS15020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z24_RS15025	COG0028	Belongs to the TPP enzyme family
E3Z24_RS15030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E3Z24_RS15035	COG0702	epimerase
E3Z24_RS15040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3Z24_RS15045	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3Z24_RS15060	COG1126	abc transporter atp-binding protein
E3Z24_RS15065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS15070	COG4215	(ABC) transporter
E3Z24_RS15075	COG4160	amino acid transport
E3Z24_RS15080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS15095	COG1177	transmembrane transport
E3Z24_RS15100	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z24_RS15105	COG3842	ATPase activity
E3Z24_RS15110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3Z24_RS15125	COG0778	Nitroreductase
E3Z24_RS15135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3Z24_RS15150	COG3226	Transcriptional regulator
E3Z24_RS15155	COG0738	Major facilitator superfamily
E3Z24_RS15160	COG0561	phosphatase activity
E3Z24_RS15170	COG2814	Major facilitator Superfamily
E3Z24_RS15175	COG0671	phosphoesterase, PA-phosphatase related
E3Z24_RS15180	COG1349	DNA-binding transcription factor activity
E3Z24_RS15185	COG1686	Belongs to the peptidase S11 family
E3Z24_RS15190	COG0625	glutathione transferase activity
E3Z24_RS15195	COG2133	pyrroloquinoline quinone binding
E3Z24_RS15210	COG2199	diguanylate cyclase activity
E3Z24_RS15220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z24_RS15230	COG0747	negative chemotaxis
E3Z24_RS15235	COG4172	Belongs to the ABC transporter superfamily
E3Z24_RS15240	COG1446	asparaginase
E3Z24_RS15245	COG0303	'Molybdopterin
E3Z24_RS15250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3Z24_RS15255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3Z24_RS15260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3Z24_RS15265	COG1882	Formate acetyltransferase
E3Z24_RS15270	COG0561	phosphatase activity
E3Z24_RS15280	COG0488	(ABC) transporter
E3Z24_RS15285	COG1376	ErfK ybiS ycfS ynhG family protein
E3Z24_RS15290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3Z24_RS15295	COG1321	iron dependent repressor
E3Z24_RS15305	COG2194	sulfuric ester hydrolase activity
E3Z24_RS15310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3Z24_RS15320	COG5006	permease, DMT superfamily
E3Z24_RS15330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS15335	COG0765	amino acid transport
E3Z24_RS15340	COG1126	abc transporter atp-binding protein
E3Z24_RS15345	COG0668	transmembrane transport
E3Z24_RS15360	COG4774	siderophore transport
E3Z24_RS15370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3Z24_RS15380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E3Z24_RS15385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3Z24_RS15390	COG1199	ATP-dependent helicase activity
E3Z24_RS15395	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
E3Z24_RS15400	COG0513	Belongs to the DEAD box helicase family
E3Z24_RS15405	COG1309	transcriptional regulator
E3Z24_RS15415	COG1131	(ABC) transporter
E3Z24_RS15420	COG0842	Transport permease protein
E3Z24_RS15425	COG0842	Transport permease protein
E3Z24_RS15435	COG3568	Endonuclease Exonuclease Phosphatase
E3Z24_RS15440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3Z24_RS15445	COG0392	lysyltransferase activity
E3Z24_RS15450	COG0670	Belongs to the BI1 family
E3Z24_RS15455	COG0670	Belongs to the BI1 family
E3Z24_RS15460	COG0314	molybdopterin synthase activity
E3Z24_RS15465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3Z24_RS15475	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3Z24_RS15485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3Z24_RS15495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3Z24_RS15500	COG2226	methyltransferase
E3Z24_RS15515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3Z24_RS15520	COG1881	PFAM PEBP family protein
E3Z24_RS15525	COG4677	pectinesterase activity
E3Z24_RS15530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3Z24_RS15535	COG0471	metal ion transport
E3Z24_RS15540	COG2828	Protein conserved in bacteria
E3Z24_RS15545	COG0583	DNA-binding transcription factor activity
E3Z24_RS15555	COG0561	phosphatase activity
E3Z24_RS15560	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3Z24_RS15565	COG4149	molybdate abc transporter
E3Z24_RS15570	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3Z24_RS15580	COG2005	Transcriptional regulator
E3Z24_RS15580	COG3585	molybdate ion transport
E3Z24_RS15585	COG1119	ATPase activity
E3Z24_RS15590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3Z24_RS15595	COG1085	galactose-1-phosphate uridylyltransferase
E3Z24_RS15605	COG2017	converts alpha-aldose to the beta-anomer
E3Z24_RS15615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3Z24_RS15625	COG1230	cation diffusion facilitator family transporter
E3Z24_RS15630	COG3201	nicotinamide mononucleotide transporter
E3Z24_RS15680	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E3Z24_RS15685	COG2885	chlorophyll binding
E3Z24_RS15695	COG3064	Membrane
E3Z24_RS15700	COG0848	biopolymer transport protein
E3Z24_RS15705	COG0811	peptide transport
E3Z24_RS15710	COG0824	Thioesterase
E3Z24_RS15715	COG3790	cyd operon protein YbgE
E3Z24_RS15720	COG4890	Cyd operon protein YbgT
E3Z24_RS15725	COG1294	oxidase, subunit
E3Z24_RS15730	COG1271	oxidase subunit
E3Z24_RS15740	COG0383	alpha-mannosidase activity
E3Z24_RS15745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS15745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS15745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS15750	COG2188	Transcriptional regulator
E3Z24_RS15755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3Z24_RS15765	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3Z24_RS15770	COG0567	Dehydrogenase, E1 component
E3Z24_RS15775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3Z24_RS15780	COG1053	succinate dehydrogenase
E3Z24_RS15785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3Z24_RS15790	COG2009	succinate dehydrogenase
E3Z24_RS15800	COG0372	Belongs to the citrate synthase family
E3Z24_RS15805	COG3539	Fimbrial protein
E3Z24_RS15810	COG3188	usher protein
E3Z24_RS15815	COG3121	Chaperone
E3Z24_RS15820	COG3539	Fimbrial protein
E3Z24_RS15825	COG3180	Ammonia monooxygenase
E3Z24_RS15840	COG1984	allophanate hydrolase subunit 2
E3Z24_RS15845	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3Z24_RS15850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3Z24_RS15855	COG3104	oligopeptide transport
E3Z24_RS15860	COG0415	Belongs to the DNA photolyase family
E3Z24_RS15865	COG3272	Protein of unknown function (DUF1722)
E3Z24_RS15900	COG3209	COG3209 Rhs family protein
E3Z24_RS15930	COG2205	protein histidine kinase activity
E3Z24_RS15935	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS15950	COG0531	amino acid
E3Z24_RS15970	COG0033	Phosphoglucomutase
E3Z24_RS15975	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E3Z24_RS15980	COG0596	Alpha beta hydrolase
E3Z24_RS15990	COG0716	FMN binding
E3Z24_RS16000	COG0735	belongs to the Fur family
E3Z24_RS16020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS16020	COG1263	PTS System
E3Z24_RS16020	COG2190	(PTS) system
E3Z24_RS16030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3Z24_RS16035	COG1940	carbohydrate kinase activity
E3Z24_RS16035	COG1846	Transcriptional regulator
E3Z24_RS16040	COG0647	UMP catabolic process
E3Z24_RS16045	COG0367	asparagine synthase
E3Z24_RS16085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z24_RS16095	COG1702	phosphate starvation-inducible protein PhoH
E3Z24_RS16105	COG4535	Mg2 and Co2 transporter CorC
E3Z24_RS16110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3Z24_RS16115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z24_RS16120	COG0765	amino acid transport
E3Z24_RS16125	COG0765	amino acid transport
E3Z24_RS16130	COG1126	abc transporter atp-binding protein
E3Z24_RS16140	COG0443	Heat shock 70 kDa protein
E3Z24_RS16145	COG2214	Heat shock protein DnaJ domain protein
E3Z24_RS16155	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3Z24_RS16160	COG2214	Heat shock protein DnaJ domain protein
E3Z24_RS16170	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3Z24_RS16175	COG2888	peptidyl-tyrosine sulfation
E3Z24_RS16190	COG1466	dna polymerase III delta subunit
E3Z24_RS16200	COG0406	alpha-ribazole phosphatase activity
E3Z24_RS16205	COG0799	negative regulation of ribosome biogenesis
E3Z24_RS16215	COG0768	penicillin binding
E3Z24_RS16220	COG0772	Belongs to the SEDS family
E3Z24_RS16225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3Z24_RS16230	COG1686	Belongs to the peptidase S11 family
E3Z24_RS16245	COG0583	DNA-binding transcription factor activity
E3Z24_RS16255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z24_RS16280	COG3069	C4-dicarboxylate transmembrane transporter activity
E3Z24_RS16285	COG4565	transcriptional regulatory protein
E3Z24_RS16290	COG3290	protein histidine kinase activity
E3Z24_RS16295	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E3Z24_RS16305	COG2301	Belongs to the HpcH HpaI aldolase family
E3Z24_RS16310	COG3051	citrate lyase alpha subunit
E3Z24_RS16325	COG0471	metal ion transport
E3Z24_RS16330	COG3719	Belongs to the RNase T2 family
E3Z24_RS16335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z24_RS16340	COG1063	alcohol dehydrogenase
E3Z24_RS16345	COG0589	response to stress
E3Z24_RS16350	COG3634	alkyl hydroperoxide reductase activity
E3Z24_RS16355	COG0450	alkyl hydroperoxide reductase
E3Z24_RS16360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3Z24_RS16365	COG0583	DNA-binding transcription factor activity
E3Z24_RS16370	COG3969	phosphoadenosine phosphosulfate
E3Z24_RS16375	COG1475	DNA binding
E3Z24_RS16380	COG0436	Aminotransferase
E3Z24_RS16385	COG0371	Dehydrogenase
E3Z24_RS16390	COG2879	small protein
E3Z24_RS16395	COG1966	Carbon starvation protein
E3Z24_RS16400	COG2050	protein possibly involved in aromatic compounds catabolism
E3Z24_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS16410	COG1535	isochorismatase
E3Z24_RS16410	COG3433	isochorismatase activity
E3Z24_RS16415	COG1021	2,3-dihydroxybenzoate-AMP ligase
E3Z24_RS16420	COG1169	isochorismate synthase
E3Z24_RS16425	COG4592	Periplasmic binding protein
E3Z24_RS16435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3Z24_RS16440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3Z24_RS16445	COG1120	ATPase activity
E3Z24_RS16450	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3Z24_RS16455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E3Z24_RS16455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z24_RS16460	COG3251	PFAM MbtH domain protein
E3Z24_RS16465	COG2382	esterase
E3Z24_RS16475	COG4771	TonB-dependent receptor
E3Z24_RS16480	COG2977	Belongs to the P-Pant transferase superfamily
E3Z24_RS16485	COG3385	transposase activity
E3Z24_RS16530	COG3423	Transcriptional regulator
E3Z24_RS16550	COG0500	methyltransferase
E3Z24_RS16555	COG0438	transferase activity, transferring glycosyl groups
E3Z24_RS16560	COG0438	transferase activity, transferring glycosyl groups
E3Z24_RS16605	COG0778	Nitroreductase
E3Z24_RS16610	COG0668	transmembrane transport
E3Z24_RS16615	COG1113	amino acid transport
E3Z24_RS16620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3Z24_RS16625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z24_RS16630	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z24_RS16635	COG1538	Outer membrane efflux protein
E3Z24_RS16640	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS16645	COG5002	protein histidine kinase activity
E3Z24_RS16650	COG1215	transferase activity, transferring glycosyl groups
E3Z24_RS16655	COG4783	chaperone-mediated protein folding
E3Z24_RS16665	COG2207	Transcriptional regulator
E3Z24_RS16675	COG2197	response regulator
E3Z24_RS16690	COG3539	Fimbrial protein
E3Z24_RS16695	COG3539	Fimbrial protein
E3Z24_RS16700	COG3188	usher protein
E3Z24_RS16705	COG3121	Chaperone
E3Z24_RS16710	COG3539	Fimbrial protein
E3Z24_RS16720	COG2501	S4 domain
E3Z24_RS16725	COG1988	membrane-bound metal-dependent
E3Z24_RS16735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3Z24_RS16745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3Z24_RS16750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3Z24_RS16755	COG0549	Belongs to the carbamate kinase family
E3Z24_RS16765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3Z24_RS16770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3Z24_RS16775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E3Z24_RS16780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3Z24_RS16785	COG3257	ureidoglycine aminohydrolase activity
E3Z24_RS16790	COG1929	Belongs to the glycerate kinase type-1 family
E3Z24_RS16795	COG2233	PERMEase
E3Z24_RS16805	COG1953	Uracil, thiamine, allantoin
E3Z24_RS16810	COG2084	Dehydrogenase
E3Z24_RS16820	COG3960	tartronate-semialdehyde synthase activity
E3Z24_RS16825	COG1414	Transcriptional regulator
E3Z24_RS16835	COG0583	DNA-binding transcription factor activity
E3Z24_RS16870	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3Z24_RS16875	COG4181	ATPase activity
E3Z24_RS16880	COG2755	lipolytic protein G-D-S-L family
E3Z24_RS16885	COG0300	oxidoreductase activity
E3Z24_RS16890	COG3118	belongs to the thioredoxin family
E3Z24_RS16895	COG0390	transport system, permease component
E3Z24_RS16900	COG4619	ABC transporter
E3Z24_RS16905	COG0330	HflC and HflK could
E3Z24_RS16910	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3Z24_RS16915	COG0789	Transcriptional regulator
E3Z24_RS16920	COG0531	amino acid
E3Z24_RS16925	COG2066	Belongs to the glutaminase family
E3Z24_RS16930	COG2217	Heavy metal translocating P-type atpase
E3Z24_RS16935	COG3093	addiction module antidote protein HigA
E3Z24_RS16945	COG3735	TraB family
E3Z24_RS16950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3Z24_RS16955	COG0737	Belongs to the 5'-nucleotidase family
E3Z24_RS16960	COG2223	nitrite transmembrane transporter activity
E3Z24_RS16965	COG4651	solute:proton antiporter activity
E3Z24_RS16965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3Z24_RS16970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS17010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3Z24_RS17020	COG2832	Protein of unknown function (DUF454)
E3Z24_RS17025	COG3923	Primosomal replication protein n
E3Z24_RS17035	COG1196	nuclear chromosome segregation
E3Z24_RS17035	COG3264	Mechanosensitive ion channel
E3Z24_RS17045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z24_RS17050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3Z24_RS17065	COG0110	maltose O-acetyltransferase activity
E3Z24_RS17075	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3Z24_RS17080	COG5507	3-demethylubiquinone-9 3-methyltransferase
E3Z24_RS17090	COG3695	enzyme binding
E3Z24_RS17095	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E3Z24_RS17100	COG1946	Acyl-CoA thioesterase
E3Z24_RS17105	COG0004	ammonium transporteR
E3Z24_RS17110	COG0347	Belongs to the P(II) protein family
E3Z24_RS17115	COG1132	(ABC) transporter
E3Z24_RS17120	COG1132	(ABC) transporter
E3Z24_RS17125	COG1522	sequence-specific DNA binding
E3Z24_RS17135	COG4533	DNA binding
E3Z24_RS17145	COG0824	Thioesterase
E3Z24_RS17150	COG1555	photosystem II stabilization
E3Z24_RS17155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z24_RS17160	COG0776	regulation of translation
E3Z24_RS17165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3Z24_RS17185	COG0271	Belongs to the BolA IbaG family
E3Z24_RS17190	COG3056	Lipoprotein
E3Z24_RS17195	COG2223	nitrite transmembrane transporter activity
E3Z24_RS17200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3Z24_RS17205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3Z24_RS17210	COG1845	cytochrome c oxidase, subunit III
E3Z24_RS17215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3Z24_RS17225	COG2814	Major facilitator Superfamily
E3Z24_RS17235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3Z24_RS17240	COG0693	protein deglycase activity
E3Z24_RS17255	COG0142	geranyltranstransferase activity
E3Z24_RS17265	COG0667	Aldo Keto reductase
E3Z24_RS17270	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3Z24_RS17275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3Z24_RS17290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3Z24_RS17290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3Z24_RS17300	COG4238	major outer membrane lipoprotein
E3Z24_RS17305	COG3248	Nucleoside-binding outer membrane protein
E3Z24_RS17310	COG1403	HNH endonuclease
E3Z24_RS17315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3Z24_RS17320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3Z24_RS17325	COG1862	Preprotein translocase
E3Z24_RS17345	COG0366	Alpha amylase catalytic
E3Z24_RS17350	COG1113	amino acid transport
E3Z24_RS17355	COG1114	Component of the transport system for branched-chain amino acids
E3Z24_RS17360	COG5002	protein histidine kinase activity
E3Z24_RS17365	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS17370	COG0420	3'-5' exonuclease activity
E3Z24_RS17375	COG0419	ATPase involved in DNA repair
E3Z24_RS17380	COG2814	Major facilitator Superfamily
E3Z24_RS17385	COG1940	carbohydrate kinase activity
E3Z24_RS17410	COG4126	flavin adenine dinucleotide binding
E3Z24_RS17430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3Z24_RS17435	COG3706	GGDEF domain
E3Z24_RS17445	COG1785	Belongs to the alkaline phosphatase family
E3Z24_RS17455	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3Z24_RS17475	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E3Z24_RS17480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3Z24_RS17485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z24_RS17490	COG3468	outer membrane autotransporter barrel domain protein
E3Z24_RS17495	COG0113	porphobilinogen synthase activity
E3Z24_RS17500	COG2175	clavaminate synthase activity
E3Z24_RS17505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3Z24_RS17515	COG4521	taurine ABC transporter
E3Z24_RS17525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3Z24_RS17530	COG1215	transferase activity, transferring glycosyl groups
E3Z24_RS17545	COG3547	Transposase (IS116 IS110 IS902 family)
E3Z24_RS17565	COG3122	Protein conserved in bacteria
E3Z24_RS17570	COG2814	Major facilitator Superfamily
E3Z24_RS17585	COG3971	2-oxopent-4-enoate hydratase activity
E3Z24_RS17605	COG1414	Transcriptional regulator
E3Z24_RS17610	COG1609	Transcriptional regulator
E3Z24_RS17615	COG3250	beta-galactosidase activity
E3Z24_RS17620	COG2223	nitrite transmembrane transporter activity
E3Z24_RS17625	COG0110	maltose O-acetyltransferase activity
E3Z24_RS17630	COG2807	transmembrane transport
E3Z24_RS17640	COG0288	reversible hydration of carbon dioxide
E3Z24_RS17645	COG0583	DNA-binding transcription factor activity
E3Z24_RS17650	COG0402	S-adenosylhomocysteine deaminase activity
E3Z24_RS17655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3Z24_RS17660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3Z24_RS17665	COG2079	MmgE PrpD family protein
E3Z24_RS17670	COG0372	Belongs to the citrate synthase family
E3Z24_RS17675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3Z24_RS17680	COG3829	transcription factor binding
E3Z24_RS17690	COG1280	lysine exporter protein (LysE YggA)
E3Z24_RS17705	COG1064	alcohol dehydrogenase
E3Z24_RS17710	COG0402	S-adenosylhomocysteine deaminase activity
E3Z24_RS17715	COG0549	Belongs to the carbamate kinase family
E3Z24_RS17725	COG1304	FMN binding
E3Z24_RS17730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3Z24_RS17740	COG0666	response to abiotic stimulus
E3Z24_RS17750	COG0583	DNA-binding transcription factor activity
E3Z24_RS17755	COG2200	EAL domain
E3Z24_RS17755	COG2771	luxR family
E3Z24_RS17765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3Z24_RS17790	COG1556	Lactate utilization protein
E3Z24_RS17795	COG1139	Iron-sulfur cluster binding protein
E3Z24_RS17800	COG0247	lactate metabolic process
E3Z24_RS17805	COG2207	Transcriptional regulator
E3Z24_RS17810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3Z24_RS17820	COG3059	membrane
E3Z24_RS17830	COG3708	Transcriptional regulator
E3Z24_RS17830	COG2207	Transcriptional regulator
E3Z24_RS17835	COG1388	LysM domain
E3Z24_RS17880	COG3188	usher protein
E3Z24_RS17890	COG3121	Chaperone
E3Z24_RS17895	COG0727	PFAM Uncharacterised protein family (UPF0153)
E3Z24_RS17900	COG3477	response to acidic pH
E3Z24_RS17905	COG2080	2 iron, 2 sulfur cluster binding
E3Z24_RS17910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3Z24_RS17915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3Z24_RS17920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3Z24_RS17925	COG0583	DNA-binding transcription factor activity
E3Z24_RS18020	COG3561	AntA/AntB antirepressor
E3Z24_RS18040	COG0582	viral genome integration into host DNA
E3Z24_RS18055	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3Z24_RS18090	COG1196	nuclear chromosome segregation
E3Z24_RS18140	COG1030	water channel activity
E3Z24_RS18160	COG4220	transposase activity
E3Z24_RS18170	COG5562	phage envelope protein
E3Z24_RS18190	COG3772	lysozyme
E3Z24_RS18220	COG1403	HNH endonuclease
E3Z24_RS18230	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3Z24_RS18245	COG1846	Transcriptional regulator
E3Z24_RS18295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E3Z24_RS18315	COG0582	viral genome integration into host DNA
E3Z24_RS18335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3Z24_RS18355	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3Z24_RS18360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3Z24_RS18365	COG1690	Belongs to the RtcB family
E3Z24_RS18370	COG0454	-acetyltransferase
E3Z24_RS18380	COG2161	toxin-antitoxin pair type II binding
E3Z24_RS18400	COG1943	Transposase
E3Z24_RS18405	COG0791	NLP P60 protein
E3Z24_RS18410	COG3077	Addiction module antitoxin, RelB DinJ family
E3Z24_RS18415	COG3041	Addiction module toxin RelE StbE family
E3Z24_RS18420	COG3034	peptidoglycan biosynthetic process
E3Z24_RS18425	COG0121	glutamine amidotransferase
E3Z24_RS18435	COG1960	acyl-CoA dehydrogenase activity
E3Z24_RS18445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3Z24_RS18450	COG5433	transposase activity
E3Z24_RS18460	COG3209	COG3209 Rhs family protein
E3Z24_RS18550	COG3157	Type VI secretion system effector, Hcp
E3Z24_RS18555	COG4104	PAAR repeat-containing protein
E3Z24_RS18575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z24_RS18585	COG2226	methyltransferase
E3Z24_RS18595	COG1388	LysM domain
E3Z24_RS18595	COG0741	lytic transglycosylase activity
E3Z24_RS18600	COG2226	methyltransferase
E3Z24_RS18610	COG0583	DNA-binding transcription factor activity
E3Z24_RS18615	COG0656	L-ascorbic acid biosynthetic process
E3Z24_RS18650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3Z24_RS18655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3Z24_RS18660	COG2011	ABC-type metal ion transport system permease component
E3Z24_RS18665	COG1464	Belongs to the NlpA lipoprotein family
E3Z24_RS18675	COG1720	tRNA m6t6A37 methyltransferase activity
E3Z24_RS18685	COG0791	NLP P60 protein
E3Z24_RS18690	COG3015	lipoprotein NlpE involved in copper resistance
E3Z24_RS18695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3Z24_RS18700	COG4681	YaeQ
E3Z24_RS18710	COG4568	rho-dependent transcription termination
E3Z24_RS18715	COG0037	tRNA processing
E3Z24_RS18720	COG0346	lactoylglutathione lyase activity
E3Z24_RS18725	COG1982	Orn Lys Arg decarboxylase major
E3Z24_RS18735	COG0587	DNA-directed DNA polymerase activity
E3Z24_RS18760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3Z24_RS18765	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E3Z24_RS18775	COG0750	zinc metalloprotease
E3Z24_RS18780	COG0575	Belongs to the CDS family
E3Z24_RS18785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3Z24_RS18790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3Z24_RS18815	COG0024	Methionine aminopeptidase
E3Z24_RS18830	COG1408	metallophosphoesterase
E3Z24_RS18845	COG3835	regulator
E3Z24_RS18850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3Z24_RS18865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3Z24_RS18870	COG2860	membrane
E3Z24_RS18895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3Z24_RS18900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3Z24_RS18905	COG1120	ATPase activity
E3Z24_RS18910	COG4774	siderophore transport
E3Z24_RS18915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3Z24_RS18920	COG1643	Atp-dependent helicase
E3Z24_RS18925	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E3Z24_RS18935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3Z24_RS18945	COG0617	tRNA 3'-terminal CCA addition
E3Z24_RS18950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3Z24_RS18955	COG3539	Fimbrial protein
E3Z24_RS18960	COG3121	Chaperone
E3Z24_RS18965	COG3188	usher protein
E3Z24_RS18970	COG3539	Fimbrial protein
E3Z24_RS18975	COG3539	Fimbrial protein
E3Z24_RS18980	COG3539	Fimbrial protein
E3Z24_RS19015	COG5464	transposase or invertase
E3Z24_RS19025	COG0726	polysaccharide deacetylase
E3Z24_RS19030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS19035	COG0842	Transport permease protein
E3Z24_RS19040	COG1131	(ABC) transporter
E3Z24_RS19045	COG0288	reversible hydration of carbon dioxide
E3Z24_RS19050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E3Z24_RS19055	COG4993	Dehydrogenase
E3Z24_RS19060	COG2132	Multicopper oxidase
E3Z24_RS19085	COG1049	propionate catabolic process, 2-methylcitrate cycle
E3Z24_RS19090	COG3064	Membrane
E3Z24_RS19095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3Z24_RS19100	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3Z24_RS19105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3Z24_RS19110	COG2186	Transcriptional regulator
E3Z24_RS19115	COG1113	amino acid transport
E3Z24_RS19120	COG3725	Membrane protein required for beta-lactamase induction
E3Z24_RS19125	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3Z24_RS19130	COG0157	Belongs to the NadC ModD family
E3Z24_RS19135	COG4969	Belongs to the N-Me-Phe pilin family
E3Z24_RS19140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3Z24_RS19145	COG1459	type II secretion system
E3Z24_RS19155	COG0237	dephospho-CoA kinase activity
E3Z24_RS19170	COG0494	nUDIX hydrolase
E3Z24_RS19190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3Z24_RS19195	COG0849	cell division
E3Z24_RS19200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3Z24_RS19205	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3Z24_RS19220	COG0772	Belongs to the SEDS family
E3Z24_RS19235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3Z24_RS19240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3Z24_RS19245	COG0768	penicillin binding
E3Z24_RS19250	COG3116	cell division
E3Z24_RS19260	COG2001	Belongs to the MraZ family
E3Z24_RS19265	COG1609	Transcriptional regulator
E3Z24_RS19275	COG0440	acetolactate synthase activity
E3Z24_RS19280	COG0028	Belongs to the TPP enzyme family
E3Z24_RS19290	COG0583	DNA-binding transcription factor activity
E3Z24_RS19305	COG0473	3-isopropylmalate dehydrogenase activity
E3Z24_RS19320	COG2814	Major facilitator Superfamily
E3Z24_RS19330	COG4533	DNA binding
E3Z24_RS19335	COG4143	(ABC) transporter
E3Z24_RS19340	COG1178	ABC-type Fe3 transport system permease component
E3Z24_RS19345	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E3Z24_RS19350	COG0586	Pfam SNARE associated Golgi protein
E3Z24_RS19355	COG4977	sequence-specific DNA binding
E3Z24_RS19360	COG1069	ribulokinase activity
E3Z24_RS19365	COG2160	L-arabinose isomerase activity
E3Z24_RS19370	COG0235	Class ii aldolase
E3Z24_RS19375	COG0417	DNA replication proofreading
E3Z24_RS19385	COG0564	pseudouridine synthase activity
E3Z24_RS19400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3Z24_RS19405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3Z24_RS19410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z24_RS19435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3Z24_RS19450	COG2271	Major facilitator Superfamily
E3Z24_RS19455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3Z24_RS19460	COG0644	oxidoreductase
E3Z24_RS19510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3Z24_RS19515	COG0505	Belongs to the CarA family
E3Z24_RS19535	COG1047	Peptidyl-prolyl cis-trans
E3Z24_RS19550	COG0196	riboflavin kinase activity
E3Z24_RS19580	COG0583	DNA-binding transcription factor activity
E3Z24_RS19600	COG3385	transposase activity
E3Z24_RS19620	COG4735	regulation of single-species biofilm formation
E3Z24_RS19625	COG1584	GPR1 FUN34 yaaH family protein
E3Z24_RS19630	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3Z24_RS19635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3Z24_RS19640	COG1115	amino acid carrier protein
E3Z24_RS19655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3Z24_RS19665	COG0527	aspartate kinase activity
E3Z24_RS19665	COG0460	homoserine dehydrogenase
E3Z24_RS19675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E3Z24_RS19685	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS19690	COG4452	Inner membrane protein CreD
E3Z24_RS19695	COG2205	protein histidine kinase activity
E3Z24_RS19700	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS19705	COG3045	CreA protein
E3Z24_RS19710	COG2207	Transcriptional regulator
E3Z24_RS19710	COG3708	Transcriptional regulator
E3Z24_RS19730	COG0741	lytic transglycosylase activity
E3Z24_RS19735	COG0488	(ABC) transporter
E3Z24_RS19740	COG3172	ATPase kinase involved in NAD metabolism
E3Z24_RS19740	COG1056	cytidyltransferase-related domain
E3Z24_RS19745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3Z24_RS19750	COG0560	Phosphoserine phosphatase
E3Z24_RS19755	COG3726	membrane protein affecting hemolysin expression
E3Z24_RS19785	COG1328	CTP reductase activity
E3Z24_RS19790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3Z24_RS19795	COG0084	hydrolase, TatD family'
E3Z24_RS19800	COG4667	esterase of the alpha-beta hydrolase superfamily
E3Z24_RS19810	COG2823	Periplasmic or secreted lipoprotein
E3Z24_RS19820	COG1011	Hydrolase
E3Z24_RS19825	COG0456	acetyltransferase
E3Z24_RS19830	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E3Z24_RS19860	COG4114	ferric iron reductase
E3Z24_RS19865	COG2197	response regulator
E3Z24_RS19870	COG2197	response regulator
E3Z24_RS19875	COG2966	Psort location CytoplasmicMembrane, score
E3Z24_RS19890	COG1484	DNA-dependent DNA replication
E3Z24_RS19905	COG1063	alcohol dehydrogenase
E3Z24_RS19910	COG1802	Transcriptional regulator
E3Z24_RS19915	COG2271	Major facilitator Superfamily
E3Z24_RS19920	COG0840	transmembrane signaling receptor activity
E3Z24_RS19925	COG1966	Carbon starvation protein
E3Z24_RS19930	COG2879	small protein
E3Z24_RS19935	COG0523	cobalamin synthesis protein
E3Z24_RS19955	COG2814	Major facilitator Superfamily
E3Z24_RS19960	COG2733	membrane
E3Z24_RS19965	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E3Z24_RS19970	COG1924	4 iron, 4 sulfur cluster binding
E3Z24_RS19985	COG0477	Major facilitator Superfamily
E3Z24_RS19995	COG3366	ferrous iron transmembrane transporter activity
E3Z24_RS20000	COG0700	Nucleoside recognition
E3Z24_RS20005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3Z24_RS20010	COG0583	DNA-binding transcription factor activity
E3Z24_RS20030	COG2186	Transcriptional regulator
E3Z24_RS20035	COG0246	Mannitol dehydrogenase
E3Z24_RS20045	COG2610	gluconate transmembrane transporter activity
E3Z24_RS20065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3Z24_RS20095	COG3436	PFAM IS66 Orf2 family protein
E3Z24_RS20100	COG4372	Transposase
E3Z24_RS20140	COG1595	DNA-templated transcription, initiation
E3Z24_RS20145	COG3712	iron ion homeostasis
E3Z24_RS20150	COG4772	TonB-dependent receptor
E3Z24_RS20155	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3Z24_RS20160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3Z24_RS20165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3Z24_RS20170	COG1120	ATPase activity
E3Z24_RS20175	COG2085	NADP oxidoreductase coenzyme F420-dependent
E3Z24_RS20185	COG3344	reverse transcriptase
E3Z24_RS20200	COG0726	polysaccharide deacetylase
E3Z24_RS20205	COG0297	glycogen (starch) synthase activity
E3Z24_RS20210	COG2990	Protein conserved in bacteria
E3Z24_RS20225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3Z24_RS20245	COG1309	transcriptional regulator
E3Z24_RS20265	COG3344	reverse transcriptase
E3Z24_RS20345	COG0582	viral genome integration into host DNA
E3Z24_RS20355	COG1064	alcohol dehydrogenase
E3Z24_RS20360	COG0433	COG0433 Predicted ATPase
E3Z24_RS20365	COG0795	lipopolysaccharide-transporting ATPase activity
E3Z24_RS20370	COG0795	lipopolysaccharide-transporting ATPase activity
E3Z24_RS20380	COG2927	DNA polymerase III (CHI subunit)
E3Z24_RS20395	COG0456	acetyltransferase
E3Z24_RS20400	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E3Z24_RS20415	COG2731	YhcH YjgK YiaL family protein
E3Z24_RS20420	COG1309	transcriptional regulator
E3Z24_RS20425	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z24_RS20430	COG0251	oxidation-reduction process
E3Z24_RS20450	COG0251	oxidation-reduction process
E3Z24_RS20455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3Z24_RS20465	COG1609	Transcriptional regulator
E3Z24_RS20470	COG1263	PTS System
E3Z24_RS20470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS20475	COG0366	Alpha amylase catalytic
E3Z24_RS20480	COG1328	CTP reductase activity
E3Z24_RS20485	COG0602	queuosine metabolic process
E3Z24_RS20490	COG3783	Cytochrome b(562)
E3Z24_RS20495	COG0312	modulator of DNA gyrase
E3Z24_RS20505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3Z24_RS20515	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS20520	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS20525	COG1129	ABC transporter
E3Z24_RS20530	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS20535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3Z24_RS20540	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3Z24_RS20545	COG2336	PFAM SpoVT AbrB
E3Z24_RS20550	COG2105	PFAM AIG2 family protein
E3Z24_RS20555	COG2911	Protein conserved in bacteria
E3Z24_RS20560	COG0729	surface antigen
E3Z24_RS20570	COG1253	flavin adenine dinucleotide binding
E3Z24_RS20580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E3Z24_RS20590	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3Z24_RS20595	COG0737	Belongs to the 5'-nucleotidase family
E3Z24_RS20600	COG1733	regulation of RNA biosynthetic process
E3Z24_RS20605	COG0702	epimerase
E3Z24_RS20610	COG0697	spore germination
E3Z24_RS20620	COG1113	amino acid transport
E3Z24_RS20625	COG0545	Peptidyl-prolyl cis-trans isomerase
E3Z24_RS20635	COG3061	Opacity-associated protein A
E3Z24_RS20645	COG0675	Transposase, IS605 OrfB family
E3Z24_RS20670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3Z24_RS20690	COG3477	response to acidic pH
E3Z24_RS20695	COG0235	Class ii aldolase
E3Z24_RS20710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS20715	COG3414	Phosphotransferase system galactitol-specific IIB component
E3Z24_RS20735	COG1073	alpha beta
E3Z24_RS20740	COG3650	response to hydrogen peroxide
E3Z24_RS20750	COG1960	acyl-CoA dehydrogenase activity
E3Z24_RS20755	COG0754	glutathionylspermidine amidase activity
E3Z24_RS20760	COG5463	Belongs to the UPF0441 family
E3Z24_RS20765	COG3766	membrane
E3Z24_RS20785	COG2721	sulfolactate sulfo-lyase activity
E3Z24_RS20790	COG2271	Major facilitator Superfamily
E3Z24_RS20795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z24_RS20800	COG1414	Transcriptional regulator
E3Z24_RS20805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3Z24_RS20815	COG0557	exoribonuclease II activity
E3Z24_RS20830	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E3Z24_RS20835	COG0330	HflC and HflK could
E3Z24_RS20840	COG0330	HflC and HflK could
E3Z24_RS20845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3Z24_RS20865	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3Z24_RS20870	COG0802	atpase or kinase
E3Z24_RS20875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3Z24_RS20875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3Z24_RS20880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3Z24_RS20920	COG1511	domain protein
E3Z24_RS20920	COG3264	Mechanosensitive ion channel
E3Z24_RS20935	COG0531	amino acid
E3Z24_RS20945	COG1053	succinate dehydrogenase
E3Z24_RS20950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3Z24_RS20965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3Z24_RS20970	COG3040	lipid binding
E3Z24_RS20975	COG2076	Multidrug Resistance protein
E3Z24_RS20980	COG5510	response to toxic substance
E3Z24_RS20985	COG5510	response to toxic substance
E3Z24_RS20995	COG1509	lysine 2,3-aminomutase activity
E3Z24_RS21020	COG0531	amino acid
E3Z24_RS21025	COG3030	protein affecting phage T7 exclusion by the F plasmid
E3Z24_RS21030	COG1027	Aspartate ammonia-lyase
E3Z24_RS21035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3Z24_RS21045	COG4232	protein-disulfide reductase activity
E3Z24_RS21050	COG1309	transcriptional regulator
E3Z24_RS21060	COG3710	Transcriptional regulator
E3Z24_RS21065	COG0531	amino acid
E3Z24_RS21070	COG1982	Orn Lys Arg decarboxylase major
E3Z24_RS21075	COG3104	oligopeptide transport
E3Z24_RS21080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3Z24_RS21095	COG2388	GCN5-related N-acetyl-transferase
E3Z24_RS21100	COG3592	Divergent 4Fe-4S mono-cluster
E3Z24_RS21105	COG3290	protein histidine kinase activity
E3Z24_RS21110	COG4565	transcriptional regulatory protein
E3Z24_RS21115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3Z24_RS21120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3Z24_RS21120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3Z24_RS21125	COG3647	Membrane
E3Z24_RS21130	COG2211	Major facilitator Superfamily
E3Z24_RS21135	COG1486	melibiose metabolic process
E3Z24_RS21140	COG2169	Transcriptional regulator
E3Z24_RS21145	COG1982	Orn Lys Arg decarboxylase major
E3Z24_RS21150	COG2207	Transcriptional regulator
E3Z24_RS21155	COG0531	amino acid
E3Z24_RS21160	COG2194	sulfuric ester hydrolase activity
E3Z24_RS21165	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS21170	COG0642	Histidine kinase
E3Z24_RS21180	COG0477	Major facilitator Superfamily
E3Z24_RS21195	COG2824	Alkylphosphonate utilization operon protein PhnA
E3Z24_RS21200	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E3Z24_RS21205	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3Z24_RS21210	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E3Z24_RS21220	COG2188	Transcriptional regulator
E3Z24_RS21225	COG3624	Phosphonate C-P lyase system protein PhnG
E3Z24_RS21230	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E3Z24_RS21235	COG3626	phosphonate metabolism
E3Z24_RS21240	COG3627	carbon phosphorus lyase activity
E3Z24_RS21245	COG4107	phosphonate C-P lyase system protein PhnK
E3Z24_RS21250	COG4778	phosphonate C-P lyase system protein PhnL
E3Z24_RS21255	COG3454	Phosphonate metabolism
E3Z24_RS21260	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E3Z24_RS21265	COG0456	acetyltransferase
E3Z24_RS21270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3Z24_RS21280	COG0698	ribose 5-phosphate isomerase
E3Z24_RS21285	COG1737	Transcriptional regulator
E3Z24_RS21290	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS21295	COG1129	ABC transporter
E3Z24_RS21300	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS21305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3Z24_RS21310	COG1940	carbohydrate kinase activity
E3Z24_RS21315	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E3Z24_RS21325	COG1566	PFAM secretion protein HlyD family protein
E3Z24_RS21330	COG1289	transmembrane transporter activity
E3Z24_RS21335	COG1538	Outer membrane efflux protein
E3Z24_RS21345	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3Z24_RS21350	COG1301	dicarboxylic acid transport
E3Z24_RS21355	COG4235	cytochrome complex assembly
E3Z24_RS21360	COG3088	subunit of a heme lyase
E3Z24_RS21365	COG1138	Cytochrome C-type biogenesis protein
E3Z24_RS21370	COG3301	Polysulphide reductase, NrfD
E3Z24_RS21375	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS21380	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E3Z24_RS21390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3Z24_RS21395	COG3162	membrane
E3Z24_RS21405	COG1357	PFAM Pentapeptide repeats (8 copies)
E3Z24_RS21410	COG0025	NhaP-type Na H and K H
E3Z24_RS21415	COG2252	PERMEase
E3Z24_RS21420	COG0789	Transcriptional regulator
E3Z24_RS21425	COG2207	Transcriptional regulator
E3Z24_RS21430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3Z24_RS21475	COG0629	single-stranded DNA binding
E3Z24_RS21480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3Z24_RS21485	COG2315	Protein conserved in bacteria
E3Z24_RS21490	COG0432	Pfam Uncharacterised protein family UPF0047
E3Z24_RS21495	COG3700	Belongs to the class B bacterial acid phosphatase family
E3Z24_RS21505	COG1448	Aminotransferase
E3Z24_RS21510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3Z24_RS21515	COG0305	Participates in initiation and elongation during chromosome replication
E3Z24_RS21520	COG0604	alcohol dehydrogenase
E3Z24_RS21530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3Z24_RS21545	COG0735	belongs to the Fur family
E3Z24_RS21550	COG3237	CsbD-like
E3Z24_RS21555	COG0534	Mate efflux family protein
E3Z24_RS21565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3Z24_RS21600	COG3842	ATPase activity
E3Z24_RS21605	COG2182	Extracellular solute-binding protein
E3Z24_RS21610	COG1175	transmembrane transport
E3Z24_RS21615	COG3833	ABC-type maltose transport systems, permease component
E3Z24_RS21620	COG2814	Major facilitator Superfamily
E3Z24_RS21620	COG0477	Major facilitator Superfamily
E3Z24_RS21635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z24_RS21660	COG0527	aspartate kinase activity
E3Z24_RS21670	COG1187	pseudouridine synthase activity
E3Z24_RS21680	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3Z24_RS21685	COG0646	methionine synthase
E3Z24_RS21685	COG1410	methionine synthase
E3Z24_RS21690	COG1414	Transcriptional regulator
E3Z24_RS21705	COG2224	Isocitrate lyase
E3Z24_RS21710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3Z24_RS21720	COG0456	acetyltransferase
E3Z24_RS21755	COG0151	Belongs to the GarS family
E3Z24_RS21760	COG2204	response regulator
E3Z24_RS21765	COG4191	Histidine kinase
E3Z24_RS21770	COG3678	ATP-independent chaperone mediated protein folding
E3Z24_RS21785	COG3068	Protein conserved in bacteria
E3Z24_RS21820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3Z24_RS21825	COG2104	thiamine diphosphate biosynthetic process
E3Z24_RS21835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3Z24_RS21875	COG0250	Participates in transcription elongation, termination and antitermination
E3Z24_RS21880	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3Z24_RS21915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E3Z24_RS21915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E3Z24_RS21920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3Z24_RS21955	COG4206	TonB-dependent receptor
E3Z24_RS21970	COG1309	transcriptional regulator
E3Z24_RS21980	COG0583	DNA-binding transcription factor activity
E3Z24_RS21995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3Z24_RS22010	COG2194	sulfuric ester hydrolase activity
E3Z24_RS22015	COG2207	Transcriptional regulator
E3Z24_RS22020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS22025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3Z24_RS22030	COG1882	Formate acetyltransferase
E3Z24_RS22035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS22040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS22045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z24_RS22045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS22045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS22050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3Z24_RS22055	COG0371	Dehydrogenase
E3Z24_RS22060	COG3738	Protein conserved in bacteria
E3Z24_RS22065	COG0697	spore germination
E3Z24_RS22075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3Z24_RS22080	COG0527	aspartate kinase activity
E3Z24_RS22080	COG0460	homoserine dehydrogenase
E3Z24_RS22085	COG0626	cystathionine gamma-synthase activity
E3Z24_RS22095	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E3Z24_RS22105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3Z24_RS22110	COG1609	Transcriptional regulator
E3Z24_RS22115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3Z24_RS22130	COG1575	Belongs to the MenA family. Type 1 subfamily
E3Z24_RS22145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3Z24_RS22155	COG1494	fructose-1,6-bisphosphatase
E3Z24_RS22160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z24_RS22165	COG0589	response to stress
E3Z24_RS22170	COG3691	Protein conserved in bacteria
E3Z24_RS22175	COG3152	Membrane
E3Z24_RS22195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3Z24_RS22260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3Z24_RS22265	COG4372	Transposase
E3Z24_RS22270	COG3436	PFAM IS66 Orf2 family protein
E3Z24_RS22290	COG1484	DNA-dependent DNA replication
E3Z24_RS22295	COG4584	PFAM Integrase catalytic
E3Z24_RS22340	COG4974	Belongs to the 'phage' integrase family
E3Z24_RS22345	COG3678	ATP-independent chaperone mediated protein folding
E3Z24_RS22350	COG0745	RESPONSE REGULATOR receiver
E3Z24_RS22355	COG2205	protein histidine kinase activity
E3Z24_RS22360	COG2258	MOSC domain
E3Z24_RS22370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3Z24_RS22410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS22415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS22415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z24_RS22420	COG1363	Peptidase, m42
E3Z24_RS22425	COG3711	transcriptional antiterminator
E3Z24_RS22425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z24_RS22445	COG0437	4 iron, 4 sulfur cluster binding
E3Z24_RS22450	COG2864	formate dehydrogenase
E3Z24_RS22460	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3Z24_RS22465	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3Z24_RS22470	COG0456	acetyltransferase
E3Z24_RS22485	COG1011	Hydrolase
E3Z24_RS22490	COG1349	DNA-binding transcription factor activity
E3Z24_RS22495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS22500	COG2084	Dehydrogenase
E3Z24_RS22505	COG3684	Belongs to the aldolase LacD family
E3Z24_RS22510	COG2942	2-epimerase
E3Z24_RS22515	COG2017	converts alpha-aldose to the beta-anomer
E3Z24_RS22520	COG1501	Belongs to the glycosyl hydrolase 31 family
E3Z24_RS22525	COG2211	Major facilitator Superfamily
E3Z24_RS22530	COG2211	Major facilitator Superfamily
E3Z24_RS22535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3Z24_RS22540	COG2271	Major facilitator Superfamily
E3Z24_RS22545	COG1082	Xylose isomerase domain protein TIM barrel
E3Z24_RS22550	COG2188	Transcriptional regulator
E3Z24_RS22555	COG1217	gtp-binding protein TYPA
E3Z24_RS22560	COG0174	glutamine synthetase
E3Z24_RS22565	COG3852	Histidine kinase
E3Z24_RS22570	COG2204	response regulator
E3Z24_RS22580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3Z24_RS22595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3Z24_RS22595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3Z24_RS22605	COG0204	Acyl-transferase
E3Z24_RS22610	COG5339	Protein conserved in bacteria
E3Z24_RS22615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3Z24_RS22620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3Z24_RS22625	COG3084	Protein conserved in bacteria
E3Z24_RS22630	COG0746	molybdenum cofactor guanylyltransferase activity
E3Z24_RS22635	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3Z24_RS22670	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E3Z24_RS22675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3Z24_RS22680	COG1739	Uncharacterized protein family UPF0029
E3Z24_RS22695	COG0183	Belongs to the thiolase family
E3Z24_RS22700	COG0543	2 iron, 2 sulfur cluster binding
E3Z24_RS22705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3Z24_RS22710	COG0250	Participates in transcription elongation, termination and antitermination
E3Z24_RS22715	COG0084	hydrolase, TatD family'
E3Z24_RS22720	COG0805	protein transport
E3Z24_RS22725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z24_RS22730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z24_RS22740	COG3165	ubiquinone biosynthetic process from chorismate
E3Z24_RS22750	COG1322	Protein conserved in bacteria
E3Z24_RS22755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E3Z24_RS22760	COG0412	Dienelactone hydrolase
E3Z24_RS22770	COG0583	DNA-binding transcription factor activity
E3Z24_RS22775	COG0697	spore germination
E3Z24_RS22780	COG0561	phosphatase activity
E3Z24_RS22785	COG2267	carboxylic ester hydrolase activity
E3Z24_RS22790	COG1280	lysine exporter protein (LysE YggA)
E3Z24_RS22795	COG1280	lysine exporter protein (LysE YggA)
E3Z24_RS22800	COG0514	ATP-dependent DNA helicase (RecQ)
E3Z24_RS22805	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E3Z24_RS22810	COG2050	protein possibly involved in aromatic compounds catabolism
E3Z24_RS22815	COG2962	Rard protein
E3Z24_RS22830	COG0598	Magnesium transport protein CorA
E3Z24_RS22835	COG3698	Phosphodiester glycosidase
E3Z24_RS22840	COG0210	DNA helicase
E3Z24_RS22845	COG1011	Hydrolase
E3Z24_RS22855	COG3159	Protein conserved in bacteria
E3Z24_RS22865	COG5567	small periplasmic lipoprotein
E3Z24_RS22880	COG3072	Adenylate cyclase
E3Z24_RS22890	COG1587	Uroporphyrinogen-III synthase
E3Z24_RS22895	COG2959	enzyme of heme biosynthesis
E3Z24_RS22900	COG3071	HemY protein
E3Z24_RS22905	COG3119	arylsulfatase activity
E3Z24_RS22910	COG0641	radical SAM
E3Z24_RS22935	COG1113	amino acid transport
E3Z24_RS22955	COG2244	polysaccharide biosynthetic process
E3Z24_RS22960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3Z24_RS22965	COG0456	acetyltransferase
E3Z24_RS22970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3Z24_RS22975	COG1088	dTDP-glucose 4,6-dehydratase activity
E3Z24_RS22980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3Z24_RS22985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3Z24_RS22990	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3Z24_RS22995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3Z24_RS23000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3Z24_RS23010	COG3118	belongs to the thioredoxin family
E3Z24_RS23025	COG0210	DNA helicase
E3Z24_RS23035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z24_RS23045	COG0583	DNA-binding transcription factor activity
E3Z24_RS23050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3Z24_RS23060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3Z24_RS23065	COG3978	acetolactate synthase activity
E3Z24_RS23085	COG0606	chelatase, subunit chli
E3Z24_RS23090	COG3085	chromosome segregation
E3Z24_RS23130	COG2186	Transcriptional regulator
E3Z24_RS23135	COG0477	Major facilitator Superfamily
E3Z24_RS23140	COG1609	Transcriptional regulator
E3Z24_RS23145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z24_RS23150	COG1879	ABC-type sugar transport system periplasmic component
E3Z24_RS23155	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z24_RS23160	COG1129	ABC transporter
E3Z24_RS23190	COG1522	sequence-specific DNA binding
E3Z24_RS23195	COG0716	FMN binding
E3Z24_RS23210	COG3312	ion transport
E3Z24_RS23260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3Z24_RS23265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3Z24_RS23270	COG0573	inorganic phosphate transmembrane transporter activity
E3Z24_RS23275	COG0581	inorganic phosphate transmembrane transporter activity
E3Z24_RS23280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3Z24_RS23285	COG0704	Plays a role in the regulation of phosphate uptake
E3Z24_RS23290	COG3711	transcriptional antiterminator
E3Z24_RS23295	COG2190	(PTS) system
E3Z24_RS23295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z24_RS23295	COG1263	PTS System
E3Z24_RS23300	COG2723	6-phospho-beta-galactosidase activity
E3Z24_RS23310	COG2382	esterase
E3Z24_RS23315	COG0363	glucosamine-6-phosphate deaminase activity
E3Z24_RS23320	COG3196	Protein conserved in bacteria
E3Z24_RS23330	COG3436	PFAM IS66 Orf2 family protein
E3Z24_RS23335	COG4372	Transposase
E3Z24_RS23350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z24_RS23355	COG2252	PERMEase
E3Z24_RS23360	COG0431	NADPH-dependent FMN reductase
E3Z24_RS23365	COG2091	lysine biosynthetic process via aminoadipic acid
E3Z24_RS23380	COG0814	amino acid
E3Z24_RS23665	COG4584	PFAM Integrase catalytic
E3Z24_RS23670	COG1484	DNA-dependent DNA replication
E3Z24_RS23680	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E3Z24_RS23755	COG4644	lycopene metabolic process
E3Z24_RS23775	COG0697	spore germination
E3Z24_RS23890	COG0673	inositol 2-dehydrogenase activity
E3Z24_RS23965	COG1695	Transcriptional regulator
E3Z24_RS24000	COG3173	Aminoglycoside phosphotransferase
E3Z24_RS24040	COG1136	(ABC) transporter
E3Z24_RS24040	COG0577	efflux transmembrane transporter activity
E3Z24_RS24045	COG1136	(ABC) transporter
E3Z24_RS24045	COG0577	efflux transmembrane transporter activity
E3Z24_RS24050	COG1136	(ABC) transporter
E3Z24_RS24050	COG0577	efflux transmembrane transporter activity
E3Z24_RS24065	COG0672	)-iron permease
E3Z24_RS24075	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E3Z24_RS24080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3Z24_RS24225	COG3344	reverse transcriptase
E3Z24_RS24245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3Z24_RS24255	COG3344	reverse transcriptase
E3Z24_RS24500	COG2805	Type II/IV secretion system protein
E3Z24_RS24580	COG0741	lytic transglycosylase activity
E3Z24_RS24595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3Z24_RS24720	COG1121	(ABC) transporter
E3Z24_RS24825	COG1660	Displays ATPase and GTPase activities
E3Z24_RS25010	COG3344	reverse transcriptase
E3Z24_RS25030	COG1475	DNA binding