locus-tag	class	description
IQS21_RS00090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IQS21_RS00125	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IQS21_RS00140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IQS21_RS00185	COG2194	sulfuric ester hydrolase activity
IQS21_RS00190	COG2271	Major facilitator Superfamily
IQS21_RS00245	COG2200	EAL domain
IQS21_RS00260	COG0582	viral genome integration into host DNA
IQS21_RS00270	COG1064	alcohol dehydrogenase
IQS21_RS00275	COG0433	COG0433 Predicted ATPase
IQS21_RS00280	COG0795	lipopolysaccharide-transporting ATPase activity
IQS21_RS00285	COG0795	lipopolysaccharide-transporting ATPase activity
IQS21_RS00295	COG2927	DNA polymerase III (CHI subunit)
IQS21_RS00300	COG0525	valine-tRNA ligase activity
IQS21_RS00305	COG4269	membrane
IQS21_RS00310	COG0456	acetyltransferase
IQS21_RS00315	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IQS21_RS00330	COG2731	YhcH YjgK YiaL family protein
IQS21_RS00335	COG1309	transcriptional regulator
IQS21_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS00345	COG0251	oxidation-reduction process
IQS21_RS00365	COG0251	oxidation-reduction process
IQS21_RS00370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IQS21_RS00380	COG1609	Transcriptional regulator
IQS21_RS00385	COG1263	PTS System
IQS21_RS00385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS00390	COG0366	Alpha amylase catalytic
IQS21_RS00395	COG1328	CTP reductase activity
IQS21_RS00400	COG0602	queuosine metabolic process
IQS21_RS00405	COG3783	Cytochrome b(562)
IQS21_RS00410	COG0312	modulator of DNA gyrase
IQS21_RS00420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IQS21_RS00430	COG1172	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS00435	COG1172	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS00440	COG1129	ABC transporter
IQS21_RS00445	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS00450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IQS21_RS00455	COG2105	PFAM AIG2 family protein
IQS21_RS00460	COG2911	Protein conserved in bacteria
IQS21_RS00465	COG0729	surface antigen
IQS21_RS00475	COG1253	flavin adenine dinucleotide binding
IQS21_RS00485	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IQS21_RS00490	COG1218	3'(2'),5'-bisphosphate nucleotidase
IQS21_RS00495	COG0737	Belongs to the 5'-nucleotidase family
IQS21_RS00500	COG1733	regulation of RNA biosynthetic process
IQS21_RS00505	COG0702	epimerase
IQS21_RS00510	COG0697	spore germination
IQS21_RS00520	COG1113	amino acid transport
IQS21_RS00525	COG0545	Peptidyl-prolyl cis-trans isomerase
IQS21_RS00530	COG3061	Opacity-associated protein A
IQS21_RS00535	COG1309	transcriptional regulator
IQS21_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS00550	COG1024	Enoyl-CoA hydratase
IQS21_RS00560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IQS21_RS00565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IQS21_RS00575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IQS21_RS00585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IQS21_RS00625	COG3414	Phosphotransferase system galactitol-specific IIB component
IQS21_RS00630	COG3037	sugar-specific permease SgaT UlaA
IQS21_RS00645	COG1073	alpha beta
IQS21_RS00650	COG3650	response to hydrogen peroxide
IQS21_RS00660	COG1960	acyl-CoA dehydrogenase activity
IQS21_RS00665	COG0754	glutathionylspermidine amidase activity
IQS21_RS00670	COG5463	Belongs to the UPF0441 family
IQS21_RS00675	COG3766	membrane
IQS21_RS00685	COG1842	Phage shock protein A
IQS21_RS00690	COG3789	protein conserved in bacteria
IQS21_RS00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQS21_RS00700	COG0557	exoribonuclease II activity
IQS21_RS00715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IQS21_RS00720	COG0330	HflC and HflK could
IQS21_RS00725	COG0330	HflC and HflK could
IQS21_RS00730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IQS21_RS00750	COG0860	N-Acetylmuramoyl-L-alanine amidase
IQS21_RS00755	COG0802	atpase or kinase
IQS21_RS00760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IQS21_RS00760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IQS21_RS00765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IQS21_RS00805	COG1511	domain protein
IQS21_RS00805	COG3264	Mechanosensitive ion channel
IQS21_RS00820	COG0531	amino acid
IQS21_RS00830	COG1053	succinate dehydrogenase
IQS21_RS00835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IQS21_RS00850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IQS21_RS00855	COG3040	lipid binding
IQS21_RS00860	COG2076	Multidrug Resistance protein
IQS21_RS00865	COG5510	response to toxic substance
IQS21_RS00870	COG5510	response to toxic substance
IQS21_RS00880	COG1509	lysine 2,3-aminomutase activity
IQS21_RS00905	COG0531	amino acid
IQS21_RS00910	COG3030	protein affecting phage T7 exclusion by the F plasmid
IQS21_RS00915	COG1027	Aspartate ammonia-lyase
IQS21_RS00920	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IQS21_RS00930	COG4232	protein-disulfide reductase activity
IQS21_RS00935	COG1309	transcriptional regulator
IQS21_RS00945	COG3710	Transcriptional regulator
IQS21_RS00950	COG0531	amino acid
IQS21_RS00955	COG1982	Orn Lys Arg decarboxylase major
IQS21_RS00960	COG3104	oligopeptide transport
IQS21_RS00965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IQS21_RS00980	COG2388	GCN5-related N-acetyl-transferase
IQS21_RS00985	COG3592	Divergent 4Fe-4S mono-cluster
IQS21_RS00990	COG3290	protein histidine kinase activity
IQS21_RS00995	COG4565	transcriptional regulatory protein
IQS21_RS01000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IQS21_RS01005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IQS21_RS01005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IQS21_RS01010	COG3647	Membrane
IQS21_RS01015	COG2211	Major facilitator Superfamily
IQS21_RS01020	COG1486	melibiose metabolic process
IQS21_RS01025	COG2169	Transcriptional regulator
IQS21_RS01030	COG1982	Orn Lys Arg decarboxylase major
IQS21_RS01035	COG2207	Transcriptional regulator
IQS21_RS01040	COG0531	amino acid
IQS21_RS01045	COG2194	sulfuric ester hydrolase activity
IQS21_RS01050	COG0745	RESPONSE REGULATOR receiver
IQS21_RS01055	COG0642	Histidine kinase
IQS21_RS01065	COG0477	Major facilitator Superfamily
IQS21_RS01080	COG2824	Alkylphosphonate utilization operon protein PhnA
IQS21_RS01085	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IQS21_RS01090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IQS21_RS01095	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IQS21_RS01105	COG2188	Transcriptional regulator
IQS21_RS01110	COG3624	Phosphonate C-P lyase system protein PhnG
IQS21_RS01115	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IQS21_RS01120	COG3626	phosphonate metabolism
IQS21_RS01125	COG3627	carbon phosphorus lyase activity
IQS21_RS01130	COG4107	phosphonate C-P lyase system protein PhnK
IQS21_RS01135	COG4778	phosphonate C-P lyase system protein PhnL
IQS21_RS01140	COG3454	Phosphonate metabolism
IQS21_RS01145	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IQS21_RS01150	COG0456	acetyltransferase
IQS21_RS01155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IQS21_RS01165	COG0698	ribose 5-phosphate isomerase
IQS21_RS01170	COG1737	Transcriptional regulator
IQS21_RS01175	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS01180	COG1129	ABC transporter
IQS21_RS01185	COG1172	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS01190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IQS21_RS01195	COG1940	carbohydrate kinase activity
IQS21_RS01200	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IQS21_RS01210	COG1566	PFAM secretion protein HlyD family protein
IQS21_RS01215	COG1289	transmembrane transporter activity
IQS21_RS01220	COG1538	Outer membrane efflux protein
IQS21_RS01230	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IQS21_RS01235	COG1301	dicarboxylic acid transport
IQS21_RS01240	COG4235	cytochrome complex assembly
IQS21_RS01245	COG3088	subunit of a heme lyase
IQS21_RS01250	COG1138	Cytochrome C-type biogenesis protein
IQS21_RS01255	COG3301	Polysulphide reductase, NrfD
IQS21_RS01260	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS01265	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IQS21_RS01275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IQS21_RS01280	COG3162	membrane
IQS21_RS01290	COG1357	PFAM Pentapeptide repeats (8 copies)
IQS21_RS01295	COG0025	NhaP-type Na H and K H
IQS21_RS01300	COG2252	PERMEase
IQS21_RS01305	COG0789	Transcriptional regulator
IQS21_RS01310	COG2207	Transcriptional regulator
IQS21_RS01315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IQS21_RS01325	COG0629	single-stranded DNA binding
IQS21_RS01330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IQS21_RS01335	COG2315	Protein conserved in bacteria
IQS21_RS01340	COG0432	Pfam Uncharacterised protein family UPF0047
IQS21_RS01345	COG3700	Belongs to the class B bacterial acid phosphatase family
IQS21_RS01355	COG1448	Aminotransferase
IQS21_RS01360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IQS21_RS01365	COG0305	Participates in initiation and elongation during chromosome replication
IQS21_RS01370	COG0604	alcohol dehydrogenase
IQS21_RS01380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQS21_RS01390	COG0735	belongs to the Fur family
IQS21_RS01395	COG3237	CsbD-like
IQS21_RS01400	COG0534	Mate efflux family protein
IQS21_RS01410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IQS21_RS01445	COG3842	ATPase activity
IQS21_RS01450	COG2182	Extracellular solute-binding protein
IQS21_RS01455	COG1175	transmembrane transport
IQS21_RS01460	COG3833	ABC-type maltose transport systems, permease component
IQS21_RS01465	COG2814	Major facilitator Superfamily
IQS21_RS01465	COG0477	Major facilitator Superfamily
IQS21_RS01485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQS21_RS01510	COG0527	aspartate kinase activity
IQS21_RS01520	COG1187	pseudouridine synthase activity
IQS21_RS01530	COG1283	sodium-dependent phosphate transmembrane transporter activity
IQS21_RS01535	COG1410	methionine synthase
IQS21_RS01535	COG0646	methionine synthase
IQS21_RS01540	COG1414	Transcriptional regulator
IQS21_RS01555	COG2224	Isocitrate lyase
IQS21_RS01560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IQS21_RS01570	COG0456	acetyltransferase
IQS21_RS01605	COG0151	Belongs to the GarS family
IQS21_RS01610	COG2204	response regulator
IQS21_RS01615	COG4191	Histidine kinase
IQS21_RS01620	COG3678	ATP-independent chaperone mediated protein folding
IQS21_RS01635	COG3068	Protein conserved in bacteria
IQS21_RS01670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IQS21_RS01675	COG2104	thiamine diphosphate biosynthetic process
IQS21_RS01685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IQS21_RS01725	COG0250	Participates in transcription elongation, termination and antitermination
IQS21_RS01730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IQS21_RS01765	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IQS21_RS01765	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IQS21_RS01770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IQS21_RS01800	COG4206	TonB-dependent receptor
IQS21_RS01815	COG1309	transcriptional regulator
IQS21_RS01825	COG0583	DNA-binding transcription factor activity
IQS21_RS01840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IQS21_RS01855	COG2194	sulfuric ester hydrolase activity
IQS21_RS01860	COG2207	Transcriptional regulator
IQS21_RS01865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS01870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IQS21_RS01880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS01885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS01890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS01890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQS21_RS01890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS01895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IQS21_RS01900	COG0371	Dehydrogenase
IQS21_RS01905	COG3738	Protein conserved in bacteria
IQS21_RS01910	COG0697	spore germination
IQS21_RS01920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IQS21_RS01925	COG0527	aspartate kinase activity
IQS21_RS01925	COG0460	homoserine dehydrogenase
IQS21_RS01930	COG0626	cystathionine gamma-synthase activity
IQS21_RS01940	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IQS21_RS01950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IQS21_RS01955	COG1609	Transcriptional regulator
IQS21_RS01960	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IQS21_RS01975	COG1575	Belongs to the MenA family. Type 1 subfamily
IQS21_RS01990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IQS21_RS02000	COG1494	fructose-1,6-bisphosphatase
IQS21_RS02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQS21_RS02010	COG0589	response to stress
IQS21_RS02015	COG3691	Protein conserved in bacteria
IQS21_RS02020	COG3152	Membrane
IQS21_RS02040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IQS21_RS02055	COG3678	ATP-independent chaperone mediated protein folding
IQS21_RS02060	COG0745	RESPONSE REGULATOR receiver
IQS21_RS02065	COG2205	protein histidine kinase activity
IQS21_RS02070	COG2258	MOSC domain
IQS21_RS02080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IQS21_RS02120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS02125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS02125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS02130	COG1363	Peptidase, m42
IQS21_RS02155	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS02160	COG2864	formate dehydrogenase
IQS21_RS02170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IQS21_RS02175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IQS21_RS02180	COG0456	acetyltransferase
IQS21_RS02195	COG1011	Hydrolase
IQS21_RS02200	COG1349	DNA-binding transcription factor activity
IQS21_RS02205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS02210	COG2084	Dehydrogenase
IQS21_RS02215	COG3684	Belongs to the aldolase LacD family
IQS21_RS02220	COG2942	2-epimerase
IQS21_RS02225	COG2017	converts alpha-aldose to the beta-anomer
IQS21_RS02230	COG1501	Belongs to the glycosyl hydrolase 31 family
IQS21_RS02235	COG2211	Major facilitator Superfamily
IQS21_RS02240	COG2211	Major facilitator Superfamily
IQS21_RS02245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IQS21_RS02250	COG2271	Major facilitator Superfamily
IQS21_RS02255	COG1082	Xylose isomerase domain protein TIM barrel
IQS21_RS02260	COG2188	Transcriptional regulator
IQS21_RS02265	COG1217	gtp-binding protein TYPA
IQS21_RS02270	COG0174	glutamine synthetase
IQS21_RS02275	COG3852	Histidine kinase
IQS21_RS02280	COG2204	response regulator
IQS21_RS02290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IQS21_RS02305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IQS21_RS02305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IQS21_RS02310	COG0204	Acyl-transferase
IQS21_RS02315	COG5339	Protein conserved in bacteria
IQS21_RS02320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IQS21_RS02325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IQS21_RS02330	COG3084	Protein conserved in bacteria
IQS21_RS02335	COG0746	molybdenum cofactor guanylyltransferase activity
IQS21_RS02340	COG1763	Mo-molybdopterin cofactor biosynthetic process
IQS21_RS02370	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IQS21_RS02375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IQS21_RS02380	COG1739	Uncharacterized protein family UPF0029
IQS21_RS02395	COG0183	Belongs to the thiolase family
IQS21_RS02400	COG0543	2 iron, 2 sulfur cluster binding
IQS21_RS02405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IQS21_RS02410	COG0250	Participates in transcription elongation, termination and antitermination
IQS21_RS02415	COG0084	hydrolase, TatD family'
IQS21_RS02420	COG0805	protein transport
IQS21_RS02425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQS21_RS02430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQS21_RS02440	COG3165	ubiquinone biosynthetic process from chorismate
IQS21_RS02450	COG1322	Protein conserved in bacteria
IQS21_RS02455	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IQS21_RS02460	COG0412	Dienelactone hydrolase
IQS21_RS02470	COG0583	DNA-binding transcription factor activity
IQS21_RS02475	COG0697	spore germination
IQS21_RS02480	COG0561	phosphatase activity
IQS21_RS02485	COG2267	carboxylic ester hydrolase activity
IQS21_RS02490	COG1280	lysine exporter protein (LysE YggA)
IQS21_RS02495	COG1280	lysine exporter protein (LysE YggA)
IQS21_RS02500	COG0514	ATP-dependent DNA helicase (RecQ)
IQS21_RS02505	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IQS21_RS02510	COG2050	protein possibly involved in aromatic compounds catabolism
IQS21_RS02515	COG2962	Rard protein
IQS21_RS02530	COG0598	Magnesium transport protein CorA
IQS21_RS02535	COG3698	Phosphodiester glycosidase
IQS21_RS02540	COG0210	DNA helicase
IQS21_RS02545	COG1011	Hydrolase
IQS21_RS02555	COG3159	Protein conserved in bacteria
IQS21_RS02565	COG5567	small periplasmic lipoprotein
IQS21_RS02575	COG3072	Adenylate cyclase
IQS21_RS02585	COG1587	Uroporphyrinogen-III synthase
IQS21_RS02590	COG2959	enzyme of heme biosynthesis
IQS21_RS02595	COG3071	HemY protein
IQS21_RS02600	COG3119	arylsulfatase activity
IQS21_RS02605	COG0641	radical SAM
IQS21_RS02630	COG1113	amino acid transport
IQS21_RS02650	COG2244	polysaccharide biosynthetic process
IQS21_RS02655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IQS21_RS02660	COG0456	acetyltransferase
IQS21_RS02665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IQS21_RS02670	COG1088	dTDP-glucose 4,6-dehydratase activity
IQS21_RS02675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IQS21_RS02680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IQS21_RS02685	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IQS21_RS02690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IQS21_RS02695	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IQS21_RS02705	COG3118	belongs to the thioredoxin family
IQS21_RS02720	COG0210	DNA helicase
IQS21_RS02730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IQS21_RS02740	COG0583	DNA-binding transcription factor activity
IQS21_RS02745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IQS21_RS02755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IQS21_RS02760	COG3978	acetolactate synthase activity
IQS21_RS02780	COG0606	chelatase, subunit chli
IQS21_RS02785	COG3085	chromosome segregation
IQS21_RS02825	COG2186	Transcriptional regulator
IQS21_RS02830	COG0477	Major facilitator Superfamily
IQS21_RS02835	COG1609	Transcriptional regulator
IQS21_RS02840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS02845	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS02850	COG1172	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS02855	COG1129	ABC transporter
IQS21_RS02885	COG1522	sequence-specific DNA binding
IQS21_RS02890	COG0716	FMN binding
IQS21_RS02905	COG3312	ion transport
IQS21_RS02955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IQS21_RS02960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IQS21_RS02965	COG0573	inorganic phosphate transmembrane transporter activity
IQS21_RS02970	COG0581	inorganic phosphate transmembrane transporter activity
IQS21_RS02975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IQS21_RS02980	COG0704	Plays a role in the regulation of phosphate uptake
IQS21_RS02985	COG3711	transcriptional antiterminator
IQS21_RS02990	COG1263	PTS System
IQS21_RS02990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS02990	COG2190	(PTS) system
IQS21_RS02995	COG2723	6-phospho-beta-galactosidase activity
IQS21_RS03005	COG2382	esterase
IQS21_RS03010	COG0363	glucosamine-6-phosphate deaminase activity
IQS21_RS03025	COG3436	PFAM IS66 Orf2 family protein
IQS21_RS03030	COG4372	Transposase
IQS21_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQS21_RS03050	COG2252	PERMEase
IQS21_RS03055	COG0431	NADPH-dependent FMN reductase
IQS21_RS03060	COG2091	lysine biosynthetic process via aminoadipic acid
IQS21_RS03075	COG0814	amino acid
IQS21_RS03125	COG0592	DNA-directed DNA polymerase activity
IQS21_RS03135	COG0187	DNA topoisomerase II activity
IQS21_RS03140	COG3753	Protein conserved in bacteria
IQS21_RS03145	COG0561	phosphatase activity
IQS21_RS03155	COG2186	Transcriptional regulator
IQS21_RS03160	COG3734	2-keto-3-deoxy-galactonokinase
IQS21_RS03165	COG0800	Aldolase
IQS21_RS03175	COG2271	Major facilitator Superfamily
IQS21_RS03185	COG0823	Involved in the tonB-independent uptake of proteins
IQS21_RS03190	COG5645	(Lipo)protein
IQS21_RS03210	COG2188	Transcriptional regulator
IQS21_RS03225	COG2207	Transcriptional regulator
IQS21_RS03230	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IQS21_RS03235	COG3119	arylsulfatase activity
IQS21_RS03245	COG2149	membrane
IQS21_RS03255	COG0641	radical SAM
IQS21_RS03260	COG2814	Major facilitator Superfamily
IQS21_RS03275	COG0028	Belongs to the TPP enzyme family
IQS21_RS03280	COG0440	acetolactate synthase activity
IQS21_RS03285	COG2197	response regulator
IQS21_RS03290	COG3851	Histidine kinase
IQS21_RS03295	COG2271	Major facilitator Superfamily
IQS21_RS03300	COG2271	Major facilitator Superfamily
IQS21_RS03310	COG2252	PERMEase
IQS21_RS03330	COG1464	Belongs to the NlpA lipoprotein family
IQS21_RS03335	COG0697	spore germination
IQS21_RS03340	COG2814	Major facilitator Superfamily
IQS21_RS03375	COG2003	Belongs to the UPF0758 family
IQS21_RS03400	COG3596	GTP binding
IQS21_RS03580	COG2916	Histone family protein nucleoid-structuring protein H-NS
IQS21_RS03590	COG2194	sulfuric ester hydrolase activity
IQS21_RS03600	COG0582	viral genome integration into host DNA
IQS21_RS03610	COG2211	Major facilitator Superfamily
IQS21_RS03615	COG1501	Belongs to the glycosyl hydrolase 31 family
IQS21_RS03620	COG2982	Protein involved in outer membrane biogenesis
IQS21_RS03625	COG2233	PERMEase
IQS21_RS03630	COG0786	glutamate:sodium symporter activity
IQS21_RS03635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IQS21_RS03640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQS21_RS03645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IQS21_RS03655	COG0194	GDP metabolic process
IQS21_RS03665	COG2860	membrane
IQS21_RS03670	COG1561	YicC-like family, N-terminal region
IQS21_RS03695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IQS21_RS03725	COG1519	Transferase
IQS21_RS03730	COG0859	PFAM glycosyl transferase family 9
IQS21_RS03735	COG0438	transferase activity, transferring glycosyl groups
IQS21_RS03740	COG0515	serine threonine protein kinase
IQS21_RS03750	COG3642	lipopolysaccharide core region biosynthetic process
IQS21_RS03770	COG0859	PFAM glycosyl transferase family 9
IQS21_RS03775	COG0859	PFAM glycosyl transferase family 9
IQS21_RS03790	COG0156	8-amino-7-oxononanoate synthase activity
IQS21_RS03800	COG1216	Glycosyl transferase, family 2
IQS21_RS03805	COG2861	carbohydrate metabolic process
IQS21_RS03810	COG4942	peptidase
IQS21_RS03820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQS21_RS03825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQS21_RS03840	COG1045	serine acetyltransferase
IQS21_RS03845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IQS21_RS03855	COG2186	Transcriptional regulator
IQS21_RS03860	COG1620	l-lactate permease
IQS21_RS03865	COG5295	Hep Hag repeat protein
IQS21_RS03885	COG3722	fumarate hydratase activity
IQS21_RS03895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS03895	COG2213	PTS system mannitol-specific
IQS21_RS03905	COG1566	PFAM secretion protein HlyD family protein
IQS21_RS03925	COG3209	COG3209 Rhs family protein
IQS21_RS03930	COG0625	glutathione transferase activity
IQS21_RS03940	COG3276	selenocysteine insertion sequence binding
IQS21_RS03945	COG1454	alcohol dehydrogenase
IQS21_RS03950	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS03965	COG1566	PFAM secretion protein HlyD family protein
IQS21_RS03970	COG0583	DNA-binding transcription factor activity
IQS21_RS03975	COG3713	MltA-interacting MipA family protein
IQS21_RS03985	COG2211	Major facilitator Superfamily
IQS21_RS03995	COG0235	Class ii aldolase
IQS21_RS04000	COG3623	hexulose-6-phosphate isomerase
IQS21_RS04005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IQS21_RS04010	COG1070	Carbohydrate kinase
IQS21_RS04015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IQS21_RS04020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IQS21_RS04025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IQS21_RS04030	COG2731	YhcH YjgK YiaL family protein
IQS21_RS04040	COG1414	Transcriptional regulator
IQS21_RS04045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS04050	COG3977	Valine--pyruvate aminotransferase
IQS21_RS04055	COG0366	Alpha amylase catalytic
IQS21_RS04060	COG2992	FlgJ-related protein
IQS21_RS04065	COG1609	Transcriptional regulator
IQS21_RS04065	COG2207	Transcriptional regulator
IQS21_RS04070	COG4214	carbohydrate transport
IQS21_RS04075	COG1129	ABC transporter
IQS21_RS04080	COG4213	ABC transporter substrate-binding protein
IQS21_RS04090	COG1070	Carbohydrate kinase
IQS21_RS04095	COG4682	membrane
IQS21_RS04100	COG4682	membrane
IQS21_RS04105	COG3274	enterobacterial common antigen metabolic process
IQS21_RS04135	COG1278	Cold shock
IQS21_RS04140	COG2944	sequence-specific DNA binding
IQS21_RS04155	COG2885	chlorophyll binding
IQS21_RS04160	COG0243	molybdopterin cofactor binding
IQS21_RS04165	COG0456	acetyltransferase
IQS21_RS04170	COG2818	Glycosylase
IQS21_RS04175	COG5571	outer membrane autotransporter
IQS21_RS04180	COG2223	nitrite transmembrane transporter activity
IQS21_RS04185	COG2194	sulfuric ester hydrolase activity
IQS21_RS04200	COG0747	negative chemotaxis
IQS21_RS04210	COG0601	transmembrane transport
IQS21_RS04215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQS21_RS04220	COG0444	Belongs to the ABC transporter superfamily
IQS21_RS04225	COG4608	Belongs to the ABC transporter superfamily
IQS21_RS04230	COG0814	amino acid
IQS21_RS04240	COG2194	sulfuric ester hydrolase activity
IQS21_RS04265	COG1215	transferase activity, transferring glycosyl groups
IQS21_RS04270	COG1215	transferase activity, transferring glycosyl groups
IQS21_RS04280	COG0457	Tetratricopeptide repeat
IQS21_RS04280	COG3118	belongs to the thioredoxin family
IQS21_RS04285	COG2200	EAL domain
IQS21_RS04285	COG2199	diguanylate cyclase activity
IQS21_RS04295	COG0612	Peptidase, M16
IQS21_RS04300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS04305	COG2200	EAL domain
IQS21_RS04310	COG2982	Protein involved in outer membrane biogenesis
IQS21_RS04315	COG0477	Major facilitator Superfamily
IQS21_RS04320	COG1295	ribonuclease BN
IQS21_RS04325	COG0583	DNA-binding transcription factor activity
IQS21_RS04330	COG2197	response regulator
IQS21_RS04340	COG1858	cytochrome C peroxidase
IQS21_RS04345	COG0076	glutamate decarboxylase activity
IQS21_RS04350	COG2207	Transcriptional regulator
IQS21_RS04355	COG2207	Transcriptional regulator
IQS21_RS04360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQS21_RS04365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS04375	COG2771	luxR family
IQS21_RS04380	COG3247	response to pH
IQS21_RS04395	COG1285	pathogenesis
IQS21_RS04400	COG2197	response regulator
IQS21_RS04405	COG3065	identical protein binding
IQS21_RS04415	COG1393	Belongs to the ArsC family
IQS21_RS04420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IQS21_RS04425	COG0640	Transcriptional regulator
IQS21_RS04435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IQS21_RS04440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IQS21_RS04445	COG0339	signal peptide processing
IQS21_RS04455	COG3104	oligopeptide transport
IQS21_RS04460	COG0589	response to stress
IQS21_RS04470	COG0306	phosphate transporter
IQS21_RS04475	COG2081	HI0933 family
IQS21_RS04495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS04500	COG1129	ABC transporter
IQS21_RS04500	COG0842	Transport permease protein
IQS21_RS04505	COG0842	Transport permease protein
IQS21_RS04510	COG5433	transposase activity
IQS21_RS04525	COG3209	COG3209 Rhs family protein
IQS21_RS04535	COG1124	(ABC) transporter
IQS21_RS04540	COG0444	Belongs to the ABC transporter superfamily
IQS21_RS04545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQS21_RS04550	COG0601	transmembrane transport
IQS21_RS04555	COG0747	negative chemotaxis
IQS21_RS04560	COG2091	lysine biosynthetic process via aminoadipic acid
IQS21_RS04565	COG0628	permease
IQS21_RS04570	COG0477	Major facilitator Superfamily
IQS21_RS04580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IQS21_RS04590	COG2217	Heavy metal translocating P-type atpase
IQS21_RS04595	COG3714	YhhN family
IQS21_RS04605	COG3776	membrane
IQS21_RS04610	COG0742	ribosomal rna small subunit methyltransferase
IQS21_RS04615	COG0552	protein localization to endoplasmic reticulum
IQS21_RS04620	COG2884	Cell division ATP-binding protein ftsE
IQS21_RS04625	COG2177	Part of the ABC transporter FtsEX involved in
IQS21_RS04630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQS21_RS04635	COG0683	leucine binding
IQS21_RS04640	COG0456	acetyltransferase
IQS21_RS04645	COG0683	leucine binding
IQS21_RS04650	COG0559	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS04655	COG4177	L-phenylalanine transmembrane transporter activity
IQS21_RS04660	COG0411	ABC transporter
IQS21_RS04665	COG0410	ABC transporter
IQS21_RS04670	COG1653	transport
IQS21_RS04675	COG1175	transmembrane transport
IQS21_RS04680	COG0395	ABC-type sugar transport system, permease component
IQS21_RS04685	COG3842	ATPase activity
IQS21_RS04690	COG0584	glycerophosphoryl diester phosphodiesterase
IQS21_RS04700	COG0405	Gamma-glutamyltransferase
IQS21_RS04720	COG3157	Type VI secretion system effector, Hcp
IQS21_RS04725	COG1247	-acetyltransferase
IQS21_RS04730	COG0673	inositol 2-dehydrogenase activity
IQS21_RS04735	COG1741	Belongs to the pirin family
IQS21_RS04740	COG1609	Transcriptional regulator
IQS21_RS04745	COG3265	gluconokinase activity
IQS21_RS04750	COG2610	gluconate transmembrane transporter activity
IQS21_RS04755	COG2095	MarC family integral membrane protein
IQS21_RS04760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IQS21_RS04785	COG0058	SHG alpha-glucan phosphorylase activity
IQS21_RS04795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IQS21_RS04810	COG1349	DNA-binding transcription factor activity
IQS21_RS04815	COG4650	regulator
IQS21_RS04820	COG1690	Belongs to the RtcB family
IQS21_RS04835	COG0058	SHG alpha-glucan phosphorylase activity
IQS21_RS04840	COG1640	4-alpha-glucanotransferase
IQS21_RS04845	COG2610	gluconate transmembrane transporter activity
IQS21_RS04855	COG1040	competence protein
IQS21_RS04865	COG5464	transposase or invertase
IQS21_RS04875	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IQS21_RS04880	COG1918	ferrous iron import across plasma membrane
IQS21_RS04885	COG2183	response to ionizing radiation
IQS21_RS04890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IQS21_RS04910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IQS21_RS04920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IQS21_RS04925	COG1011	Hydrolase
IQS21_RS04935	COG0494	nUDIX hydrolase
IQS21_RS04940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IQS21_RS04945	COG4972	Pilus assembly protein
IQS21_RS04950	COG3166	PFAM Fimbrial assembly family protein
IQS21_RS04965	COG4796	Type ii and iii secretion system protein
IQS21_RS04980	COG3266	domain, Protein
IQS21_RS04985	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IQS21_RS04990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IQS21_RS04995	COG0546	phosphoglycolate phosphatase activity
IQS21_RS05000	COG0180	Tryptophanyl-tRNA synthetase
IQS21_RS05005	COG2188	Transcriptional regulator
IQS21_RS05015	COG3457	Alanine racemase
IQS21_RS05020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IQS21_RS05025	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IQS21_RS05040	COG0626	cystathionine gamma-synthase activity
IQS21_RS05045	COG2188	Transcriptional regulator
IQS21_RS05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS05055	COG1082	Xylose isomerase domain protein TIM barrel
IQS21_RS05060	COG2222	sugar isomerase
IQS21_RS05065	COG0531	amino acid
IQS21_RS05080	COG2116	formate transmembrane transporter activity
IQS21_RS05085	COG2146	nitrite reductase [NAD(P)H] activity
IQS21_RS05090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IQS21_RS05100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQS21_RS05110	COG2184	nucleotidyltransferase activity
IQS21_RS05115	COG0512	Glutamine amidotransferase of anthranilate synthase
IQS21_RS05120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IQS21_RS05125	COG1289	transmembrane transporter activity
IQS21_RS05130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQS21_RS05135	COG1765	OsmC-like protein
IQS21_RS05140	COG3954	Phosphoribulokinase
IQS21_RS05150	COG0429	hydrolase of the alpha beta-hydrolase fold
IQS21_RS05155	COG0488	(ABC) transporter
IQS21_RS05170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IQS21_RS05175	COG1047	Peptidyl-prolyl cis-trans
IQS21_RS05185	COG0545	Peptidyl-prolyl cis-trans isomerase
IQS21_RS05190	COG2964	Protein conserved in bacteria
IQS21_RS05230	COG3979	chitinase
IQS21_RS05235	COG2906	2 iron, 2 sulfur cluster binding
IQS21_RS05240	COG2193	ferroxidase activity
IQS21_RS05245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IQS21_RS05250	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IQS21_RS05255	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IQS21_RS05260	COG3156	type II secretion system protein K
IQS21_RS05265	COG4795	General secretion pathway protein
IQS21_RS05270	COG2165	general secretion pathway protein
IQS21_RS05275	COG2165	general secretion pathway protein
IQS21_RS05280	COG2165	general secretion pathway protein
IQS21_RS05285	COG1459	type II secretion system
IQS21_RS05290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IQS21_RS05295	COG1450	Type ii and iii secretion system protein
IQS21_RS05300	COG3031	protein transport across the cell outer membrane
IQS21_RS05305	COG3409	Peptidoglycan-binding domain 1 protein
IQS21_RS05305	COG3267	Type II secretory pathway component ExeA
IQS21_RS05330	COG0089	rRNA binding
IQS21_RS05420	COG0201	protein transport
IQS21_RS05460	COG0789	Transcriptional regulator
IQS21_RS05465	COG3036	rescue of stalled ribosome
IQS21_RS05475	COG0569	domain protein
IQS21_RS05495	COG0758	DNA mediated transformation
IQS21_RS05505	COG0551	DNA topoisomerase type I activity
IQS21_RS05525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IQS21_RS05565	COG1126	abc transporter atp-binding protein
IQS21_RS05570	COG0765	amino acid transport
IQS21_RS05575	COG4597	amino acid ABC transporter
IQS21_RS05600	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IQS21_RS05610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQS21_RS05620	COG4145	pantothenate transmembrane transporter activity
IQS21_RS05625	COG3924	membrane
IQS21_RS05630	COG0439	Biotin carboxylase
IQS21_RS05635	COG0511	ligase activity, forming carbon-carbon bonds
IQS21_RS05640	COG0604	alcohol dehydrogenase
IQS21_RS05645	COG2200	EAL domain
IQS21_RS05645	COG2199	diguanylate cyclase activity
IQS21_RS05650	COG1077	Cell shape determining protein MreB Mrl
IQS21_RS05655	COG1792	Involved in formation and maintenance of cell shape
IQS21_RS05660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IQS21_RS05665	COG0424	maF-like protein
IQS21_RS05670	COG1530	ribonuclease E activity
IQS21_RS05675	COG3164	Protein of unknown function
IQS21_RS05680	COG0312	modulator of DNA gyrase
IQS21_RS05685	COG0583	DNA-binding transcription factor activity
IQS21_RS05705	COG2732	(Barnase) inhibitor
IQS21_RS05725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQS21_RS05730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQS21_RS05735	COG3105	Protein conserved in bacteria
IQS21_RS05740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IQS21_RS05755	COG0625	glutathione transferase activity
IQS21_RS05760	COG2969	positive regulation of protein catabolic process
IQS21_RS05765	COG3069	C4-dicarboxylate transmembrane transporter activity
IQS21_RS05795	COG2731	YhcH YjgK YiaL family protein
IQS21_RS05800	COG4804	nuclease activity
IQS21_RS05805	COG3539	Fimbrial protein
IQS21_RS05815	COG3188	usher protein
IQS21_RS05820	COG3121	Chaperone
IQS21_RS05825	COG3539	Fimbrial protein
IQS21_RS05830	COG0493	'glutamate synthase
IQS21_RS05835	COG0069	glutamate synthase activity
IQS21_RS05835	COG0070	glutamate synthase
IQS21_RS05835	COG0067	glutamate synthase
IQS21_RS05840	COG1242	4 iron, 4 sulfur cluster binding
IQS21_RS05845	COG0784	Response regulator, receiver
IQS21_RS05845	COG5002	protein histidine kinase activity
IQS21_RS05845	COG2198	Histidine kinase
IQS21_RS05850	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IQS21_RS05860	COG0515	serine threonine protein kinase
IQS21_RS05865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS05880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IQS21_RS05885	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IQS21_RS05890	COG1137	ATPase activity
IQS21_RS05895	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IQS21_RS05900	COG3117	lipopolysaccharide transmembrane transporter activity
IQS21_RS05905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IQS21_RS05910	COG0517	IMP dehydrogenase activity
IQS21_RS05910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IQS21_RS05915	COG0530	calcium, potassium:sodium antiporter activity
IQS21_RS05920	COG1127	ABC transporter
IQS21_RS05925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IQS21_RS05930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IQS21_RS05935	COG2854	intermembrane phospholipid transfer
IQS21_RS05940	COG3113	response to antibiotic
IQS21_RS05945	COG5007	Belongs to the BolA IbaG family
IQS21_RS05955	COG3423	Transcriptional regulator
IQS21_RS05960	COG0142	geranyltranstransferase activity
IQS21_RS05975	COG0697	spore germination
IQS21_RS05985	COG2027	D-alanyl-D-alanine carboxypeptidase
IQS21_RS05990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IQS21_RS05995	COG1534	Rna-binding protein
IQS21_RS06005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IQS21_RS06010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IQS21_RS06020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IQS21_RS06030	COG2194	sulfuric ester hydrolase activity
IQS21_RS06050	COG0195	Participates in both transcription termination and antitermination
IQS21_RS06090	COG0513	Belongs to the DEAD box helicase family
IQS21_RS06095	COG0814	amino acid
IQS21_RS06100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IQS21_RS06105	COG0826	peptidase U32
IQS21_RS06110	COG0826	peptidase U32
IQS21_RS06115	COG3154	lipid carrier protein
IQS21_RS06120	COG3153	acetyltransferase
IQS21_RS06135	COG0693	protein deglycase activity
IQS21_RS06140	COG0702	epimerase
IQS21_RS06145	COG0701	Predicted permease
IQS21_RS06150	COG2823	Periplasmic or secreted lipoprotein
IQS21_RS06165	COG3107	peptidoglycan biosynthetic process
IQS21_RS06170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IQS21_RS06175	COG3539	Fimbrial protein
IQS21_RS06180	COG3188	usher protein
IQS21_RS06185	COG3121	Chaperone
IQS21_RS06190	COG3539	Fimbrial protein
IQS21_RS06195	COG0363	glucosamine-6-phosphate deaminase activity
IQS21_RS06200	COG3716	PTS system mannose fructose sorbose family IID component
IQS21_RS06220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS06230	COG2222	sugar isomerase
IQS21_RS06235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IQS21_RS06240	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS06245	COG3716	PTS system mannose fructose sorbose family IID component
IQS21_RS06255	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS06265	COG1349	DNA-binding transcription factor activity
IQS21_RS06275	COG2002	toxin-antitoxin pair type II binding
IQS21_RS06280	COG2721	sulfolactate sulfo-lyase activity
IQS21_RS06285	COG2271	Major facilitator Superfamily
IQS21_RS06295	COG2084	Dehydrogenase
IQS21_RS06300	COG1929	Belongs to the glycerate kinase type-1 family
IQS21_RS06325	COG0583	DNA-binding transcription factor activity
IQS21_RS06330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IQS21_RS06340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IQS21_RS06345	COG1882	Formate acetyltransferase
IQS21_RS06350	COG0251	oxidation-reduction process
IQS21_RS06355	COG1760	l-serine dehydratase
IQS21_RS06360	COG0814	amino acid
IQS21_RS06375	COG1741	Belongs to the pirin family
IQS21_RS06380	COG0583	DNA-binding transcription factor activity
IQS21_RS06385	COG3152	Membrane
IQS21_RS06390	COG3152	Membrane
IQS21_RS06395	COG0435	Glutathione S-transferase
IQS21_RS06400	COG2259	Doxx family
IQS21_RS06410	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IQS21_RS06415	COG4575	ribosome binding
IQS21_RS06420	COG1422	Protein of unknown function (DUF1090)
IQS21_RS06430	COG0586	Pfam SNARE associated Golgi protein
IQS21_RS06435	COG2186	Transcriptional regulator
IQS21_RS06440	COG2271	Major facilitator Superfamily
IQS21_RS06450	COG2721	sulfolactate sulfo-lyase activity
IQS21_RS06460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IQS21_RS06465	COG0861	Integral membrane protein TerC family
IQS21_RS06470	COG0673	inositol 2-dehydrogenase activity
IQS21_RS06475	COG2949	membrane
IQS21_RS06480	COG1451	nucleotide metabolic process
IQS21_RS06490	COG4680	protein conserved in bacteria
IQS21_RS06495	COG5499	transcription regulator containing HTH domain
IQS21_RS06500	COG1902	pentaerythritol trinitrate reductase activity
IQS21_RS06500	COG0446	pyridine nucleotide-disulphide oxidoreductase
IQS21_RS06505	COG3408	Glycogen debranching enzyme
IQS21_RS06505	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IQS21_RS06515	COG0531	amino acid
IQS21_RS06520	COG2731	YhcH YjgK YiaL family protein
IQS21_RS06525	COG3250	beta-galactosidase activity
IQS21_RS06530	COG1609	Transcriptional regulator
IQS21_RS06535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IQS21_RS06545	COG0840	transmembrane signaling receptor activity
IQS21_RS06550	COG1695	Transcriptional regulator
IQS21_RS06555	COG2375	cellular response to nickel ion
IQS21_RS06570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQS21_RS06575	COG0358	DNA primase activity
IQS21_RS06580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IQS21_RS06590	COG0471	metal ion transport
IQS21_RS06595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IQS21_RS06600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IQS21_RS06605	COG0583	DNA-binding transcription factor activity
IQS21_RS06615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IQS21_RS06630	COG4991	sh3 domain protein
IQS21_RS06635	COG3025	triphosphatase activity
IQS21_RS06660	COG2268	Band 7 protein
IQS21_RS06665	COG1585	Membrane protein implicated in regulation of membrane protease activity
IQS21_RS06675	COG3539	Fimbrial protein
IQS21_RS06680	COG3121	Chaperone
IQS21_RS06685	COG3188	usher protein
IQS21_RS06690	COG3539	Fimbrial protein
IQS21_RS06695	COG2960	long-chain fatty acid transporting porin activity
IQS21_RS06715	COG3384	dioxygenase
IQS21_RS06720	COG0754	glutathionylspermidine amidase activity
IQS21_RS06730	COG1538	Outer membrane efflux protein
IQS21_RS06735	COG0494	nUDIX hydrolase
IQS21_RS06740	COG3151	Protein conserved in bacteria
IQS21_RS06745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IQS21_RS06750	COG3150	esterase
IQS21_RS06755	COG0187	DNA topoisomerase II activity
IQS21_RS06760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IQS21_RS06765	COG2249	NAD(P)H dehydrogenase (quinone) activity
IQS21_RS06775	COG0642	Histidine kinase
IQS21_RS06780	COG0745	RESPONSE REGULATOR receiver
IQS21_RS06785	COG3111	PFAM Bacterial OB fold (BOF) protein
IQS21_RS06790	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IQS21_RS06800	COG2944	sequence-specific DNA binding
IQS21_RS06805	COG4166	transmembrane transport
IQS21_RS06810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IQS21_RS06815	COG0204	Acyl-transferase
IQS21_RS06820	COG2132	Multicopper oxidase
IQS21_RS06825	COG1032	radical SAM domain protein
IQS21_RS06830	COG4238	major outer membrane lipoprotein
IQS21_RS06840	COG0656	L-ascorbic acid biosynthetic process
IQS21_RS06845	COG1979	alcohol dehydrogenase
IQS21_RS06850	COG2207	Transcriptional regulator
IQS21_RS06855	COG0586	Pfam SNARE associated Golgi protein
IQS21_RS06860	COG0626	cystathionine gamma-synthase activity
IQS21_RS06865	COG0811	peptide transport
IQS21_RS06870	COG0848	biopolymer transport protein
IQS21_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS06885	COG0667	Aldo Keto reductase
IQS21_RS06900	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IQS21_RS06905	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS06910	COG5557	Pfam Polysulphide reductase, NrfD
IQS21_RS06915	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IQS21_RS06920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IQS21_RS06925	COG1773	rubredoxin
IQS21_RS06935	COG0298	carbon dioxide binding
IQS21_RS06940	COG0625	glutathione transferase activity
IQS21_RS06945	COG0754	glutathionylspermidine amidase activity
IQS21_RS06950	COG0306	phosphate transporter
IQS21_RS06955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IQS21_RS06970	COG3121	Chaperone
IQS21_RS06975	COG3539	Fimbrial protein
IQS21_RS06985	COG1585	Membrane protein implicated in regulation of membrane protease activity
IQS21_RS06995	COG0582	viral genome integration into host DNA
IQS21_RS07005	COG1811	Na channel or pump
IQS21_RS07010	COG1982	Orn Lys Arg decarboxylase major
IQS21_RS07015	COG2211	Major facilitator Superfamily
IQS21_RS07030	COG1194	a g-specific adenine glycosylase
IQS21_RS07040	COG3171	Protein conserved in bacteria
IQS21_RS07050	COG0252	asparaginase activity
IQS21_RS07060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IQS21_RS07065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IQS21_RS07075	COG0762	integral membrane protein
IQS21_RS07080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IQS21_RS07085	COG2805	Type II/IV secretion system protein
IQS21_RS07100	COG0189	ligase activity
IQS21_RS07105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IQS21_RS07110	COG2356	endonuclease I
IQS21_RS07120	COG2814	Major facilitator Superfamily
IQS21_RS07140	COG1166	arginine decarboxylase activity
IQS21_RS07150	COG0501	Belongs to the peptidase M48B family
IQS21_RS07155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IQS21_RS07160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS07165	COG2213	PTS system mannitol-specific
IQS21_RS07170	COG1063	alcohol dehydrogenase
IQS21_RS07175	COG1494	fructose-1,6-bisphosphatase
IQS21_RS07180	COG3722	fumarate hydratase activity
IQS21_RS07185	COG1072	(Pantothenic acid kinase))
IQS21_RS07200	COG0191	fructose-bisphosphate aldolase activity
IQS21_RS07205	COG0668	transmembrane transport
IQS21_RS07210	COG1279	arginine transmembrane transporter activity
IQS21_RS07215	COG2968	Membrane
IQS21_RS07220	COG0583	DNA-binding transcription factor activity
IQS21_RS07225	COG0427	acetyl-CoA hydrolase
IQS21_RS07230	COG1024	Enoyl-CoA hydratase
IQS21_RS07235	COG1703	isobutyryl-CoA mutase activity
IQS21_RS07240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IQS21_RS07240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IQS21_RS07260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IQS21_RS07270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IQS21_RS07290	COG0006	proline dipeptidase activity
IQS21_RS07295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQS21_RS07300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQS21_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS07330	COG2723	6-phospho-beta-galactosidase activity
IQS21_RS07340	COG1272	protein, Hemolysin III
IQS21_RS07350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IQS21_RS07360	COG0716	FMN binding
IQS21_RS07365	COG4974	Belongs to the 'phage' integrase family
IQS21_RS07370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IQS21_RS07375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IQS21_RS07385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IQS21_RS07405	COG2233	PERMEase
IQS21_RS07410	COG0493	'glutamate synthase
IQS21_RS07410	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS07415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS07420	COG2252	PERMEase
IQS21_RS07425	COG0402	S-adenosylhomocysteine deaminase activity
IQS21_RS07430	COG2233	PERMEase
IQS21_RS07435	COG2080	2 iron, 2 sulfur cluster binding
IQS21_RS07435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IQS21_RS07440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IQS21_RS07445	COG0402	S-adenosylhomocysteine deaminase activity
IQS21_RS07450	COG0493	'glutamate synthase
IQS21_RS07450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS07455	COG2068	MobA-Related Protein
IQS21_RS07460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IQS21_RS07465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IQS21_RS07465	COG3608	succinylglutamate desuccinylase aspartoacylase
IQS21_RS07470	COG0549	Belongs to the carbamate kinase family
IQS21_RS07480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IQS21_RS07485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IQS21_RS07490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IQS21_RS07495	COG3829	transcription factor binding
IQS21_RS07500	COG2080	2 iron, 2 sulfur cluster binding
IQS21_RS07505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IQS21_RS07510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IQS21_RS07515	COG4942	peptidase
IQS21_RS07530	COG3385	transposase activity
IQS21_RS07630	COG0457	Tetratricopeptide repeat
IQS21_RS07630	COG3710	Transcriptional regulator
IQS21_RS07635	COG0457	Tetratricopeptide repeat
IQS21_RS07660	COG3710	Transcriptional regulator
IQS21_RS07665	COG2771	luxR family
IQS21_RS07670	COG0814	amino acid
IQS21_RS07675	COG0183	Belongs to the thiolase family
IQS21_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS07690	COG2814	Major facilitator Superfamily
IQS21_RS07695	COG1794	racemase activity, acting on amino acids and derivatives
IQS21_RS07700	COG0583	DNA-binding transcription factor activity
IQS21_RS07710	COG1609	Transcriptional regulator
IQS21_RS07725	COG0667	Aldo Keto reductase
IQS21_RS07735	COG0861	Integral membrane protein TerC family
IQS21_RS07750	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IQS21_RS07765	COG2165	general secretion pathway protein
IQS21_RS07770	COG4795	General secretion pathway protein
IQS21_RS07780	COG4967	type IV pilus modification protein PilV
IQS21_RS07785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IQS21_RS07790	COG1025	Belongs to the peptidase M16 family
IQS21_RS07795	COG1074	ATP-dependent DNA helicase activity
IQS21_RS07800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IQS21_RS07805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IQS21_RS07805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IQS21_RS07810	COG0860	N-Acetylmuramoyl-L-alanine amidase
IQS21_RS07830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IQS21_RS07835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IQS21_RS07840	COG2166	iron-sulfur cluster assembly
IQS21_RS07845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IQS21_RS07855	COG0583	DNA-binding transcription factor activity
IQS21_RS07860	COG2363	Small membrane protein
IQS21_RS07870	COG1349	DNA-binding transcription factor activity
IQS21_RS07880	COG1070	Carbohydrate kinase
IQS21_RS07890	COG0738	Major facilitator superfamily
IQS21_RS07895	COG0235	Class ii aldolase
IQS21_RS07900	COG1454	alcohol dehydrogenase
IQS21_RS07910	COG1760	l-serine dehydratase
IQS21_RS07915	COG0814	amino acid
IQS21_RS07920	COG1611	Belongs to the LOG family
IQS21_RS07935	COG3098	single-species biofilm formation
IQS21_RS07940	COG0564	pseudouridine synthase activity
IQS21_RS07945	COG0716	FMN binding
IQS21_RS07950	COG2271	Major facilitator Superfamily
IQS21_RS07955	COG4948	Mandelate Racemase Muconate Lactonizing
IQS21_RS07960	COG4948	Mandelate Racemase Muconate Lactonizing
IQS21_RS07965	COG4999	Histidine kinase
IQS21_RS07965	COG3850	Histidine kinase
IQS21_RS07965	COG2205	protein histidine kinase activity
IQS21_RS07965	COG3437	response regulator, receiver
IQS21_RS07970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IQS21_RS07975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IQS21_RS07980	COG2336	PFAM SpoVT AbrB
IQS21_RS07985	COG2337	Toxic component of a toxin-antitoxin (TA) module
IQS21_RS07990	COG3956	TIGRFAM MazG family protein
IQS21_RS08005	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IQS21_RS08015	COG0602	queuosine metabolic process
IQS21_RS08020	COG1070	Carbohydrate kinase
IQS21_RS08025	COG2223	nitrite transmembrane transporter activity
IQS21_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS08035	COG0277	FAD linked oxidase domain protein
IQS21_RS08040	COG0477	Major facilitator Superfamily
IQS21_RS08045	COG2086	electron transfer activity
IQS21_RS08050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IQS21_RS08055	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IQS21_RS08060	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IQS21_RS08065	COG0644	oxidoreductase
IQS21_RS08070	COG0720	synthase
IQS21_RS08090	COG1203	CRISPR-associated helicase, Cas3
IQS21_RS08105	COG1857	crispr-associated protein
IQS21_RS08120	COG1518	maintenance of DNA repeat elements
IQS21_RS08125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IQS21_RS08130	COG2234	aminopeptidase activity
IQS21_RS08185	COG4942	peptidase
IQS21_RS08185	COG1388	LysM domain
IQS21_RS08190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IQS21_RS08195	COG2610	gluconate transmembrane transporter activity
IQS21_RS08205	COG0235	Class ii aldolase
IQS21_RS08210	COG3395	kinase activity
IQS21_RS08215	COG2084	Dehydrogenase
IQS21_RS08220	COG1349	DNA-binding transcription factor activity
IQS21_RS08225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IQS21_RS08245	COG3604	Transcriptional regulator
IQS21_RS08250	COG0309	Hydrogenase expression formation protein (HypE)
IQS21_RS08255	COG0409	Hydrogenase expression formation protein
IQS21_RS08260	COG0298	carbon dioxide binding
IQS21_RS08265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IQS21_RS08270	COG0375	protein maturation
IQS21_RS08280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS08285	COG0651	ATP synthesis coupled electron transport
IQS21_RS08290	COG0650	Formate hydrogenlyase subunit 4
IQS21_RS08295	COG3261	NADH dehydrogenase
IQS21_RS08295	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IQS21_RS08300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQS21_RS08305	COG3260	NADH ubiquinone oxidoreductase 20
IQS21_RS08315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IQS21_RS08320	COG2723	6-phospho-beta-galactosidase activity
IQS21_RS08325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS08325	COG1263	PTS System
IQS21_RS08330	COG1609	Transcriptional regulator
IQS21_RS08335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS08340	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IQS21_RS08360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IQS21_RS08360	COG0517	IMP dehydrogenase activity
IQS21_RS08365	COG1349	DNA-binding transcription factor activity
IQS21_RS08370	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS08375	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS08380	COG3731	PTS system glucitol sorbitol-specific IIA component
IQS21_RS08385	COG3732	PTS system glucitol sorbitol-specific
IQS21_RS08390	COG3730	PTS system glucitol sorbitol-specific
IQS21_RS08395	COG2951	lytic endotransglycosylase activity
IQS21_RS08400	COG1546	Belongs to the CinA family
IQS21_RS08420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IQS21_RS08450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQS21_RS08455	COG1238	metal cluster binding
IQS21_RS08470	COG2814	Major facilitator Superfamily
IQS21_RS08475	COG1566	PFAM secretion protein HlyD family protein
IQS21_RS08480	COG1846	Transcriptional regulator
IQS21_RS08490	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IQS21_RS08495	COG2814	Major facilitator Superfamily
IQS21_RS08500	COG2113	Glycine betaine
IQS21_RS08505	COG4176	ABC-type proline glycine betaine transport system permease component
IQS21_RS08510	COG4175	Glycine betaine
IQS21_RS08515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQS21_RS08520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQS21_RS08530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQS21_RS08535	COG4575	ribosome binding
IQS21_RS08550	COG2916	Histone family protein nucleoid-structuring protein H-NS
IQS21_RS08555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQS21_RS08560	COG0640	Transcriptional regulator
IQS21_RS08565	COG0401	homolog of Blt101
IQS21_RS08570	COG1652	LysM domain
IQS21_RS08575	COG1802	Transcriptional regulator
IQS21_RS08580	COG1113	amino acid transport
IQS21_RS08585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IQS21_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS08595	COG0579	oxidoreductase
IQS21_RS08630	COG3468	outer membrane autotransporter barrel domain protein
IQS21_RS08645	COG2867	negative regulation of translational initiation
IQS21_RS08655	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQS21_RS08660	COG0497	DNA recombination
IQS21_RS08675	COG4536	flavin adenine dinucleotide binding
IQS21_RS08680	COG4137	Cytochrome C assembly protein
IQS21_RS08685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IQS21_RS08715	COG2199	diguanylate cyclase activity
IQS21_RS08730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IQS21_RS08735	COG0287	Prephenate dehydrogenase
IQS21_RS08735	COG1605	Chorismate mutase
IQS21_RS08740	COG0077	Prephenate dehydratase
IQS21_RS08740	COG1605	Chorismate mutase
IQS21_RS08750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IQS21_RS08755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQS21_RS08760	COG0564	pseudouridine synthase activity
IQS21_RS08765	COG1496	oxidoreductase activity
IQS21_RS08770	COG0542	response to heat
IQS21_RS08795	COG0477	Major facilitator Superfamily
IQS21_RS08800	COG5544	Lipoprotein
IQS21_RS08805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IQS21_RS08810	COG1042	CoA-binding domain protein
IQS21_RS08810	COG0045	succinate-CoA ligase (ADP-forming) activity
IQS21_RS08810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IQS21_RS08815	COG3148	PFAM DTW domain containing protein
IQS21_RS08820	COG3118	belongs to the thioredoxin family
IQS21_RS08825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IQS21_RS08845	COG0583	DNA-binding transcription factor activity
IQS21_RS08850	COG0513	Belongs to the DEAD box helicase family
IQS21_RS08860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IQS21_RS08870	COG1595	DNA-templated transcription, initiation
IQS21_RS08875	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IQS21_RS08880	COG3026	antisigma factor binding
IQS21_RS08885	COG3086	response to oxidative stress
IQS21_RS08895	COG0681	Belongs to the peptidase S26 family
IQS21_RS08915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IQS21_RS08930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS08935	COG1737	Transcriptional regulator
IQS21_RS08940	COG0560	Phosphoserine phosphatase
IQS21_RS08955	COG0047	phosphoribosylformylglycinamidine synthase activity
IQS21_RS08955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IQS21_RS08960	COG2205	protein histidine kinase activity
IQS21_RS08965	COG3170	Tfp pilus assembly protein FimV
IQS21_RS08970	COG2204	response regulator
IQS21_RS08975	COG0347	Belongs to the P(II) protein family
IQS21_RS08980	COG1017	nitric oxide dioxygenase activity
IQS21_RS08980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQS21_RS08990	COG1940	carbohydrate kinase activity
IQS21_RS08995	COG0457	Tetratricopeptide repeat
IQS21_RS09000	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS09005	COG1129	ABC transporter
IQS21_RS09010	COG1172	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS09015	COG1063	alcohol dehydrogenase
IQS21_RS09020	COG2017	converts alpha-aldose to the beta-anomer
IQS21_RS09025	COG2259	Doxx family
IQS21_RS09050	COG4638	Rieske (2fe-2S)
IQS21_RS09055	COG0583	DNA-binding transcription factor activity
IQS21_RS09060	COG2814	Major facilitator Superfamily
IQS21_RS09065	COG3711	transcriptional antiterminator
IQS21_RS09070	COG1073	alpha beta
IQS21_RS09075	COG0483	inositol monophosphate 1-phosphatase activity
IQS21_RS09095	COG0822	iron-sulfur transferase activity
IQS21_RS09115	COG0633	Ferredoxin
IQS21_RS09120	COG2975	iron-sulfur cluster assembly
IQS21_RS09135	COG2897	thiosulfate sulfurtransferase activity
IQS21_RS09140	COG2373	Large extracellular alpha-helical protein
IQS21_RS09145	COG4953	penicillin-binding protein 1C
IQS21_RS09175	COG2976	Protein conserved in bacteria
IQS21_RS09190	COG1645	bacterial-type flagellum-dependent swarming motility
IQS21_RS09200	COG0516	GMP reductase activity
IQS21_RS09200	COG0517	IMP dehydrogenase activity
IQS21_RS09230	COG4691	Plasmid stability protein
IQS21_RS09265	COG0798	PFAM Bile acid sodium symporter
IQS21_RS09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IQS21_RS09315	COG3133	Outer membrane lipoprotein
IQS21_RS09330	COG2200	EAL domain
IQS21_RS09335	COG0248	Ppx GppA phosphatase
IQS21_RS09340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IQS21_RS09345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IQS21_RS09360	COG2233	PERMEase
IQS21_RS09370	COG1393	Belongs to the ArsC family
IQS21_RS09375	COG4783	chaperone-mediated protein folding
IQS21_RS09380	COG0628	permease
IQS21_RS09385	COG2116	formate transmembrane transporter activity
IQS21_RS09390	COG3604	Transcriptional regulator
IQS21_RS09400	COG3260	NADH ubiquinone oxidoreductase 20
IQS21_RS09405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQS21_RS09410	COG3261	NADH dehydrogenase
IQS21_RS09410	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IQS21_RS09415	COG0651	ATP synthesis coupled electron transport
IQS21_RS09420	COG4237	Hydrogenase 4 membrane
IQS21_RS09425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQS21_RS09430	COG0650	Formate hydrogenlyase subunit 4
IQS21_RS09435	COG0651	ATP synthesis coupled electron transport
IQS21_RS09440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS09445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IQS21_RS09450	COG2716	regulation of RNA biosynthetic process
IQS21_RS09460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IQS21_RS09470	COG2321	neutral zinc metallopeptidase
IQS21_RS09475	COG1444	tRNA N-acetyltransferase activity
IQS21_RS09480	COG0400	carboxylic ester hydrolase activity
IQS21_RS09495	COG1393	Belongs to the ArsC family
IQS21_RS09505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQS21_RS09510	COG3850	Histidine kinase
IQS21_RS09515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS09515	COG0493	'glutamate synthase
IQS21_RS09525	COG5342	invasion associated locus B
IQS21_RS09530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IQS21_RS09535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IQS21_RS09540	COG0281	malic enzyme
IQS21_RS09540	COG0280	phosphate acetyltransferase
IQS21_RS09545	COG4810	utilization protein
IQS21_RS09550	COG4917	ethanolamine utilization protein
IQS21_RS09555	COG4766	ethanolamine catabolic process
IQS21_RS09560	COG4812	Cobalamin adenosyltransferase
IQS21_RS09565	COG0280	phosphate acetyltransferase
IQS21_RS09570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQS21_RS09575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IQS21_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS09585	COG4820	ethanolamine utilization protein (EutJ)
IQS21_RS09590	COG1454	alcohol dehydrogenase
IQS21_RS09595	COG3192	ethanolamine utilization protein
IQS21_RS09600	COG4819	ethanolamine utilization protein
IQS21_RS09605	COG4303	Ethanolamine ammonia lyase large subunit
IQS21_RS09615	COG4816	utilization protein
IQS21_RS09620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IQS21_RS09625	COG2207	Transcriptional regulator
IQS21_RS09635	COG0860	N-Acetylmuramoyl-L-alanine amidase
IQS21_RS09640	COG0456	acetyltransferase
IQS21_RS09655	COG2837	iron assimilation
IQS21_RS09660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IQS21_RS09665	COG1263	PTS System
IQS21_RS09665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS09685	COG4150	thiosulfate binding
IQS21_RS09690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IQS21_RS09695	COG4208	sulfate ABC transporter
IQS21_RS09700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IQS21_RS09705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IQS21_RS09710	COG3831	ATPase activity
IQS21_RS09710	COG4884	unkown
IQS21_RS09725	COG2190	(PTS) system
IQS21_RS09730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQS21_RS09735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS09740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IQS21_RS09760	COG3530	Putative quorum-sensing-regulated virulence factor
IQS21_RS09765	COG0385	Bile acid
IQS21_RS09770	COG0583	DNA-binding transcription factor activity
IQS21_RS09780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IQS21_RS09785	COG2211	Major facilitator Superfamily
IQS21_RS09795	COG0583	DNA-binding transcription factor activity
IQS21_RS09830	COG3415	Transposase
IQS21_RS09835	COG3415	Transposase
IQS21_RS09850	COG2199	diguanylate cyclase activity
IQS21_RS09850	COG2200	EAL domain
IQS21_RS09855	COG3385	transposase activity
IQS21_RS09860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IQS21_RS09885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS09890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS09895	COG0006	proline dipeptidase activity
IQS21_RS09900	COG1363	Peptidase, m42
IQS21_RS09905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS09905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQS21_RS09905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS09915	COG3279	Response regulator of the LytR AlgR family
IQS21_RS09920	COG3275	phosphorelay sensor kinase activity
IQS21_RS09925	COG0436	Aminotransferase
IQS21_RS09935	COG1560	Kdo2-lipid A biosynthetic process
IQS21_RS09960	COG0028	Belongs to the TPP enzyme family
IQS21_RS09965	COG0679	Auxin Efflux Carrier
IQS21_RS09970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IQS21_RS09975	COG0784	Response regulator, receiver
IQS21_RS09975	COG2205	protein histidine kinase activity
IQS21_RS09975	COG2198	Histidine kinase
IQS21_RS09975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS09980	COG2197	response regulator
IQS21_RS09985	COG1566	PFAM secretion protein HlyD family protein
IQS21_RS09990	COG0477	Major facilitator Superfamily
IQS21_RS10000	COG2610	gluconate transmembrane transporter activity
IQS21_RS10005	COG0583	DNA-binding transcription factor activity
IQS21_RS10015	COG2116	formate transmembrane transporter activity
IQS21_RS10020	COG2853	Lipoprotein
IQS21_RS10030	COG2067	long-chain fatty acid transport protein
IQS21_RS10035	COG3691	Protein conserved in bacteria
IQS21_RS10050	COG2062	phosphohistidine phosphatase, SixA
IQS21_RS10055	COG3539	Fimbrial protein
IQS21_RS10060	COG3188	usher protein
IQS21_RS10065	COG3121	Chaperone
IQS21_RS10070	COG3539	Fimbrial protein
IQS21_RS10075	COG3539	Fimbrial protein
IQS21_RS10080	COG3539	Fimbrial protein
IQS21_RS10095	COG2890	protein-(glutamine-N5) methyltransferase activity
IQS21_RS10110	COG0730	response to heat
IQS21_RS10115	COG3101	peptidyl-lysine hydroxylation
IQS21_RS10130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IQS21_RS10135	COG2814	Major facilitator Superfamily
IQS21_RS10150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IQS21_RS10160	COG0586	Pfam SNARE associated Golgi protein
IQS21_RS10170	COG0285	dihydrofolate synthase activity
IQS21_RS10175	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IQS21_RS10180	COG1286	toxin biosynthetic process
IQS21_RS10185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IQS21_RS10190	COG0163	prenyltransferase activity
IQS21_RS10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS10200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS10205	COG4215	(ABC) transporter
IQS21_RS10210	COG4160	amino acid transport
IQS21_RS10215	COG4598	ABC transporter
IQS21_RS10220	COG5464	transposase or invertase
IQS21_RS10225	COG1090	epimerase
IQS21_RS10230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IQS21_RS10235	COG0625	glutathione transferase activity
IQS21_RS10240	COG0625	glutathione transferase activity
IQS21_RS10245	COG0622	Phosphoesterase
IQS21_RS10250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IQS21_RS10255	COG1288	antiporter activity
IQS21_RS10260	COG0857	belongs to the CobB CobQ family
IQS21_RS10260	COG0280	phosphate acetyltransferase
IQS21_RS10265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IQS21_RS10280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQS21_RS10285	COG0490	domain, Protein
IQS21_RS10285	COG0471	metal ion transport
IQS21_RS10295	COG0436	Aminotransferase
IQS21_RS10300	COG0583	DNA-binding transcription factor activity
IQS21_RS10320	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IQS21_RS10325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IQS21_RS10330	COG1034	ATP synthesis coupled electron transport
IQS21_RS10345	COG0839	Belongs to the complex I subunit 6 family
IQS21_RS10355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IQS21_RS10360	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQS21_RS10370	COG0457	Tetratricopeptide repeat
IQS21_RS10390	COG2234	aminopeptidase activity
IQS21_RS10395	COG2304	oxidoreductase activity
IQS21_RS10415	COG5160	protein modification by small protein removal
IQS21_RS10425	COG2153	protein acetylation
IQS21_RS10430	COG4575	ribosome binding
IQS21_RS10435	COG1169	isochorismate synthase
IQS21_RS10450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IQS21_RS10460	COG0318	PFAM AMP-dependent synthetase and ligase
IQS21_RS10535	COG2271	Major facilitator Superfamily
IQS21_RS10550	COG5464	transposase or invertase
IQS21_RS10555	COG0247	lactate metabolic process
IQS21_RS10565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IQS21_RS10585	COG4221	oxidoreductase activity
IQS21_RS10605	COG3328	transposase activity
IQS21_RS10775	COG3300	MHYT domain
IQS21_RS10775	COG5001	Diguanylate cyclase
IQS21_RS10805	COG0584	glycerophosphoryl diester phosphodiesterase
IQS21_RS10815	COG3642	lipopolysaccharide core region biosynthetic process
IQS21_RS10820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQS21_RS10825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQS21_RS10830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IQS21_RS10835	COG3468	outer membrane autotransporter barrel domain protein
IQS21_RS10845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IQS21_RS10850	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
IQS21_RS10855	COG3234	Protein of unknown function (DUF1175)
IQS21_RS10860	COG2373	Large extracellular alpha-helical protein
IQS21_RS10865	COG5445	Predicted secreted protein (DUF2300)
IQS21_RS10870	COG4676	Protein conserved in bacteria
IQS21_RS10875	COG2826	transposase and inactivated derivatives, IS30 family
IQS21_RS10880	COG0183	Belongs to the thiolase family
IQS21_RS10885	COG2031	fatty acid transporter
IQS21_RS10890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IQS21_RS10895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IQS21_RS10900	COG2204	response regulator
IQS21_RS10905	COG3852	Histidine kinase
IQS21_RS10910	COG0784	Response regulator, receiver
IQS21_RS10910	COG2205	protein histidine kinase activity
IQS21_RS10915	COG2197	response regulator
IQS21_RS10920	COG0642	Histidine kinase
IQS21_RS10920	COG2198	Histidine kinase
IQS21_RS10925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IQS21_RS10930	COG1477	protein flavinylation
IQS21_RS10935	COG2169	Transcriptional regulator
IQS21_RS10935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IQS21_RS10940	COG3145	DNA-N1-methyladenine dioxygenase activity
IQS21_RS10945	COG4615	Cyclic peptide transporter
IQS21_RS10965	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS10965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IQS21_RS10970	COG3062	negative regulation of establishment of protein localization
IQS21_RS10980	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS10985	COG0348	domain, Protein
IQS21_RS10990	COG3043	anaerobic respiration
IQS21_RS10995	COG3005	denitrification pathway
IQS21_RS11000	COG4133	protoheme IX ABC transporter activity
IQS21_RS11005	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IQS21_RS11010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IQS21_RS11015	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IQS21_RS11025	COG1138	Cytochrome C-type biogenesis protein
IQS21_RS11030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IQS21_RS11035	COG4235	cytochrome complex assembly
IQS21_RS11035	COG3088	subunit of a heme lyase
IQS21_RS11040	COG2197	response regulator
IQS21_RS11045	COG3468	outer membrane autotransporter barrel domain protein
IQS21_RS11055	COG3083	sulfuric ester hydrolase activity
IQS21_RS11075	COG1061	Type III restriction enzyme res subunit
IQS21_RS11080	COG1187	pseudouridine synthase activity
IQS21_RS11085	COG2814	Major facilitator Superfamily
IQS21_RS11095	COG4172	Belongs to the ABC transporter superfamily
IQS21_RS11100	COG4239	(ABC) transporter, permease
IQS21_RS11105	COG4174	ABC transporter (Permease)
IQS21_RS11110	COG4166	transmembrane transport
IQS21_RS11115	COG2200	EAL domain
IQS21_RS11120	COG0791	NLP P60 protein
IQS21_RS11125	COG0671	phosphoesterase, PA-phosphatase related
IQS21_RS11130	COG0523	cobalamin synthesis protein
IQS21_RS11135	COG0246	Mannitol dehydrogenase
IQS21_RS11150	COG2814	Major facilitator Superfamily
IQS21_RS11155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS11155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS11160	COG1105	Belongs to the carbohydrate kinase PfkB family
IQS21_RS11165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IQS21_RS11165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS11165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS11170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS11175	COG2313	pseudouridylate synthase activity
IQS21_RS11180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IQS21_RS11205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IQS21_RS11210	COG1522	sequence-specific DNA binding
IQS21_RS11210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS11220	COG2855	membrane
IQS21_RS11225	COG0583	DNA-binding transcription factor activity
IQS21_RS11230	COG0833	amino acid
IQS21_RS11235	COG4771	TonB-dependent receptor
IQS21_RS11240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IQS21_RS11250	COG2311	Membrane
IQS21_RS11255	COG1609	Transcriptional regulator
IQS21_RS11260	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS11265	COG1129	ABC transporter
IQS21_RS11270	COG4211	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS11275	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IQS21_RS11275	COG0167	dihydroorotate dehydrogenase activity
IQS21_RS11280	COG0493	'glutamate synthase
IQS21_RS11290	COG2949	membrane
IQS21_RS11300	COG1346	cytolysis
IQS21_RS11310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IQS21_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS11330	COG0586	Pfam SNARE associated Golgi protein
IQS21_RS11340	COG1686	Belongs to the peptidase S11 family
IQS21_RS11345	COG0277	FAD linked oxidase domain protein
IQS21_RS11350	COG1472	Belongs to the glycosyl hydrolase 3 family
IQS21_RS11355	COG1732	Glycine betaine
IQS21_RS11360	COG1174	glycine betaine transport
IQS21_RS11365	COG1125	glycine betaine transport
IQS21_RS11370	COG1174	glycine betaine transport
IQS21_RS11380	COG0789	Transcriptional regulator
IQS21_RS11385	COG3275	phosphorelay sensor kinase activity
IQS21_RS11390	COG3279	Response regulator of the LytR AlgR family
IQS21_RS11395	COG4807	Protein conserved in bacteria
IQS21_RS11400	COG4808	Protein conserved in bacteria
IQS21_RS11405	COG4715	Zinc finger, swim domain protein
IQS21_RS11410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IQS21_RS11415	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IQS21_RS11420	COG0714	Associated with various cellular activities
IQS21_RS11430	COG3831	ATPase activity
IQS21_RS11445	COG0489	protein tyrosine kinase activity
IQS21_RS11455	COG3539	Fimbrial protein
IQS21_RS11460	COG3121	Chaperone
IQS21_RS11465	COG3188	usher protein
IQS21_RS11470	COG3539	Fimbrial protein
IQS21_RS11475	COG5455	response to cobalt ion
IQS21_RS11495	COG0351	phosphomethylpyrimidine kinase
IQS21_RS11500	COG3757	hydrolase, family 25
IQS21_RS11505	COG2188	Transcriptional regulator
IQS21_RS11510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS11515	COG1397	ADP-ribosylglycohydrolase
IQS21_RS11520	COG2211	Major facilitator Superfamily
IQS21_RS11525	COG1830	Aldolase
IQS21_RS11535	COG1069	ribulokinase activity
IQS21_RS11560	COG1070	Carbohydrate kinase
IQS21_RS11570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQS21_RS11585	COG0826	peptidase U32
IQS21_RS11595	COG0745	RESPONSE REGULATOR receiver
IQS21_RS11600	COG2205	protein histidine kinase activity
IQS21_RS11635	COG4245	von Willebrand factor, type A
IQS21_RS11640	COG0631	protein serine/threonine phosphatase activity
IQS21_RS11645	COG3779	Protein conserved in bacteria
IQS21_RS11650	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
IQS21_RS11655	COG0443	Heat shock 70 kDa protein
IQS21_RS11660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IQS21_RS11665	COG5001	Diguanylate cyclase
IQS21_RS11665	COG3447	MASE1 domain protein
IQS21_RS11665	COG5002	protein histidine kinase activity
IQS21_RS11670	COG0572	uridine kinase
IQS21_RS11680	COG2982	Protein involved in outer membrane biogenesis
IQS21_RS11695	COG1253	flavin adenine dinucleotide binding
IQS21_RS11795	COG1088	dTDP-glucose 4,6-dehydratase activity
IQS21_RS11855	COG0438	transferase activity, transferring glycosyl groups
IQS21_RS11865	COG0140	phosphoribosyl-ATP diphosphatase activity
IQS21_RS11865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IQS21_RS11880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IQS21_RS11885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IQS21_RS11885	COG0131	Imidazoleglycerol-phosphate dehydratase
IQS21_RS11895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IQS21_RS11910	COG2161	toxin-antitoxin pair type II binding
IQS21_RS11915	COG4115	mRNA cleavage
IQS21_RS11920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQS21_RS11925	COG0583	DNA-binding transcription factor activity
IQS21_RS11935	COG0531	amino acid
IQS21_RS11940	COG2391	methyltransferase activity
IQS21_RS11945	COG0425	Belongs to the sulfur carrier protein TusA family
IQS21_RS11950	COG2925	Exonuclease
IQS21_RS12135	COG3646	Phage regulatory protein
IQS21_RS12155	COG1783	phage Terminase large subunit
IQS21_RS12240	COG1686	Belongs to the peptidase S11 family
IQS21_RS12250	COG1289	transmembrane transporter activity
IQS21_RS12295	COG2003	Belongs to the UPF0758 family
IQS21_RS12320	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
IQS21_RS12335	COG1376	ErfK ybiS ycfS ynhG family protein
IQS21_RS12345	COG0583	DNA-binding transcription factor activity
IQS21_RS12350	COG0583	DNA-binding transcription factor activity
IQS21_RS12360	COG0534	Mate efflux family protein
IQS21_RS12370	COG0217	transcriptional regulatory protein
IQS21_RS12375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IQS21_RS12380	COG0477	Major facilitator Superfamily
IQS21_RS12390	COG1388	LysM domain
IQS21_RS12390	COG1470	cell adhesion involved in biofilm formation
IQS21_RS12415	COG3443	Belongs to the bacterial solute-binding protein 9 family
IQS21_RS12430	COG2351	hydroxyisourate hydrolase activity
IQS21_RS12435	COG0745	RESPONSE REGULATOR receiver
IQS21_RS12440	COG2205	protein histidine kinase activity
IQS21_RS12455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IQS21_RS12465	COG1418	mRNA catabolic process
IQS21_RS12470	COG0270	DNA (cytosine-5-)-methyltransferase activity
IQS21_RS12475	COG3727	T/G mismatch-specific endonuclease activity
IQS21_RS12480	COG0697	spore germination
IQS21_RS12485	COG2354	Protein conserved in bacteria
IQS21_RS12490	COG5475	Uncharacterized small protein (DUF2158)
IQS21_RS12515	COG2197	response regulator
IQS21_RS12520	COG1684	flagellar biosynthetic protein fliR
IQS21_RS12525	COG1987	bacterial-type flagellum assembly
IQS21_RS12530	COG1338	Plays a role in the flagellum-specific transport system
IQS21_RS12535	COG3190	flagellar
IQS21_RS12540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IQS21_RS12545	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IQS21_RS12550	COG1580	Controls the rotational direction of flagella during chemotaxis
IQS21_RS12555	COG3144	bacterial-type flagellum assembly
IQS21_RS12570	COG1317	bacterial-type flagellum organization
IQS21_RS12575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IQS21_RS12580	COG1766	The M ring may be actively involved in energy transduction
IQS21_RS12600	COG2135	peptidase activity
IQS21_RS12605	COG0425	Belongs to the sulfur carrier protein TusA family
IQS21_RS12610	COG2391	methyltransferase activity
IQS21_RS12620	COG0366	Alpha amylase catalytic
IQS21_RS12630	COG1516	flagellar protein fliS
IQS21_RS12635	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IQS21_RS12645	COG1191	sigma factor activity
IQS21_RS12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS12665	COG0765	amino acid transport
IQS21_RS12670	COG1126	abc transporter atp-binding protein
IQS21_RS12675	COG2197	response regulator
IQS21_RS12690	COG2197	response regulator
IQS21_RS12720	COG3318	Belongs to the UPF0149 family
IQS21_RS12720	COG3012	SEC-C Motif Domain Protein
IQS21_RS12725	COG0814	amino acid
IQS21_RS12735	COG1528	Iron-storage protein
IQS21_RS12755	COG1528	Iron-storage protein
IQS21_RS12760	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS12765	COG1129	ABC transporter
IQS21_RS12770	COG1172	Belongs to the binding-protein-dependent transport system permease family
IQS21_RS12775	COG1877	trehalose-phosphatase activity
IQS21_RS12785	COG0589	response to stress
IQS21_RS12800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IQS21_RS12805	COG1360	Flagellar Motor Protein
IQS21_RS12810	COG0643	Histidine kinase
IQS21_RS12810	COG2198	Histidine kinase
IQS21_RS12815	COG0835	chemotaxis
IQS21_RS12820	COG0840	transmembrane signaling receptor activity
IQS21_RS12825	COG0840	transmembrane signaling receptor activity
IQS21_RS12830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IQS21_RS12835	COG2201	protein-glutamate methylesterase activity
IQS21_RS12840	COG0745	RESPONSE REGULATOR receiver
IQS21_RS12845	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IQS21_RS12850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IQS21_RS12855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IQS21_RS12865	COG3755	Protein conserved in bacteria
IQS21_RS12875	COG3102	Protein conserved in bacteria
IQS21_RS12885	COG3005	denitrification pathway
IQS21_RS12890	COG0243	molybdopterin cofactor binding
IQS21_RS12905	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IQS21_RS12910	COG1801	Protein of unknown function DUF72
IQS21_RS12915	COG1335	isochorismatase
IQS21_RS12925	COG0494	nUDIX hydrolase
IQS21_RS12930	COG0217	transcriptional regulatory protein
IQS21_RS12960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IQS21_RS12970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IQS21_RS12975	COG0739	heme binding
IQS21_RS12980	COG1560	Kdo2-lipid A biosynthetic process
IQS21_RS12985	COG0469	pyruvate kinase activity
IQS21_RS12990	COG1737	Transcriptional regulator
IQS21_RS12995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IQS21_RS13000	COG0129	dihydroxy-acid dehydratase activity
IQS21_RS13005	COG0800	Aldolase
IQS21_RS13015	COG3141	response to X-ray
IQS21_RS13025	COG2979	Protein of unknown function (DUF533)
IQS21_RS13030	COG1770	oligopeptidase
IQS21_RS13035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IQS21_RS13040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQS21_RS13050	COG2372	response to copper ion
IQS21_RS13055	COG1276	copper resistance
IQS21_RS13065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IQS21_RS13085	COG3008	intermembrane lipid transfer
IQS21_RS13090	COG2995	paraquat-inducible protein a
IQS21_RS13095	COG1956	GAF domain-containing protein
IQS21_RS13105	COG0793	Belongs to the peptidase S41A family
IQS21_RS13115	COG2814	Major facilitator Superfamily
IQS21_RS13120	COG1414	Transcriptional regulator
IQS21_RS13150	COG2226	methyltransferase
IQS21_RS13165	COG3716	PTS system mannose fructose sorbose family IID component
IQS21_RS13170	COG3715	PTS system
IQS21_RS13175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS13175	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS13180	COG1253	flavin adenine dinucleotide binding
IQS21_RS13190	COG1760	l-serine dehydratase
IQS21_RS13200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IQS21_RS13215	COG0251	oxidation-reduction process
IQS21_RS13220	COG1199	ATP-dependent helicase activity
IQS21_RS13225	COG1214	PFAM Peptidase M22, glycoprotease
IQS21_RS13230	COG3065	identical protein binding
IQS21_RS13235	COG0318	PFAM AMP-dependent synthetase and ligase
IQS21_RS13240	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IQS21_RS13245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQS21_RS13250	COG4638	Rieske (2fe-2S)
IQS21_RS13260	COG0473	3-isopropylmalate dehydrogenase activity
IQS21_RS13265	COG0583	DNA-binding transcription factor activity
IQS21_RS13275	COG3615	Tellurite resistance protein tehB
IQS21_RS13285	COG2261	transglycosylase associated protein
IQS21_RS13300	COG2203	Gaf domain
IQS21_RS13300	COG2199	diguanylate cyclase activity
IQS21_RS13305	COG3042	response to heat
IQS21_RS13310	COG3189	MarR family transcriptional regulator
IQS21_RS13315	COG2807	transmembrane transport
IQS21_RS13320	COG2207	Transcriptional regulator
IQS21_RS13335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IQS21_RS13340	COG2199	diguanylate cyclase activity
IQS21_RS13345	COG2199	diguanylate cyclase activity
IQS21_RS13355	COG2766	serine protein kinase
IQS21_RS13360	COG3713	MltA-interacting MipA family protein
IQS21_RS13365	COG0656	L-ascorbic acid biosynthetic process
IQS21_RS13370	COG0676	glucose-6-phosphate 1-epimerase activity
IQS21_RS13375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IQS21_RS13385	COG3139	Protein of unknown function (DUF1315)
IQS21_RS13390	COG1063	alcohol dehydrogenase
IQS21_RS13395	COG2271	Major facilitator Superfamily
IQS21_RS13400	COG1063	alcohol dehydrogenase
IQS21_RS13405	COG0191	fructose-bisphosphate aldolase activity
IQS21_RS13410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS13415	COG0667	Aldo Keto reductase
IQS21_RS13420	COG1349	DNA-binding transcription factor activity
IQS21_RS13425	COG2814	Major facilitator Superfamily
IQS21_RS13430	COG1335	isochorismatase
IQS21_RS13435	COG0252	asparaginase activity
IQS21_RS13440	COG0616	signal peptide processing
IQS21_RS13445	COG0778	Nitroreductase
IQS21_RS13455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IQS21_RS13465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IQS21_RS13475	COG0494	nUDIX hydrolase
IQS21_RS13480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IQS21_RS13485	COG2897	thiosulfate sulfurtransferase activity
IQS21_RS13490	COG4136	ATPase activity
IQS21_RS13495	COG4135	transport system, permease component
IQS21_RS13500	COG4134	Bacterial extracellular solute-binding protein
IQS21_RS13505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IQS21_RS13510	COG0398	Pfam SNARE associated Golgi protein
IQS21_RS13520	COG0398	Pfam SNARE associated Golgi protein
IQS21_RS13525	COG0708	Exodeoxyribonuclease III
IQS21_RS13555	COG3678	ATP-independent chaperone mediated protein folding
IQS21_RS13565	COG0322	excinuclease ABC activity
IQS21_RS13575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQS21_RS13580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IQS21_RS13585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IQS21_RS13590	COG1447	Phosphotransferase system cellobiose-specific component IIA
IQS21_RS13595	COG2169	Transcriptional regulator
IQS21_RS13595	COG1917	Cupin 2, conserved barrel domain protein
IQS21_RS13600	COG1486	melibiose metabolic process
IQS21_RS13610	COG0753	catalase activity
IQS21_RS13625	COG1823	symporter activity
IQS21_RS13630	COG1988	membrane-bound metal-dependent
IQS21_RS13635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQS21_RS13645	COG3001	Fructosamine kinase
IQS21_RS13655	COG1105	Belongs to the carbohydrate kinase PfkB family
IQS21_RS13660	COG3137	Salt-induced outer membrane protein
IQS21_RS13705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IQS21_RS13705	COG0072	phenylalanine-tRNA ligase activity
IQS21_RS13720	COG0386	Belongs to the glutathione peroxidase family
IQS21_RS13730	COG0791	NLP P60 protein
IQS21_RS13735	COG2200	EAL domain
IQS21_RS13745	COG4256	Hemin uptake protein
IQS21_RS13750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IQS21_RS13760	COG0574	Belongs to the PEP-utilizing enzyme family
IQS21_RS13760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQS21_RS13765	COG0318	PFAM AMP-dependent synthetase and ligase
IQS21_RS13770	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IQS21_RS13775	COG0644	oxidoreductase
IQS21_RS13780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IQS21_RS13785	COG2086	electron transfer activity
IQS21_RS13790	COG2207	Transcriptional regulator
IQS21_RS13790	COG1917	Cupin 2, conserved barrel domain protein
IQS21_RS13795	COG1960	acyl-CoA dehydrogenase activity
IQS21_RS13800	COG4670	ketone body catabolic process
IQS21_RS13815	COG2271	Major facilitator Superfamily
IQS21_RS13820	COG0738	Major facilitator superfamily
IQS21_RS13835	COG0628	permease
IQS21_RS13840	COG0247	lactate metabolic process
IQS21_RS13840	COG0277	FAD linked oxidase domain protein
IQS21_RS13845	COG2050	protein possibly involved in aromatic compounds catabolism
IQS21_RS13855	COG0316	Belongs to the HesB IscA family
IQS21_RS13860	COG0719	Fe-S assembly protein
IQS21_RS13865	COG0396	ATPase activity
IQS21_RS13870	COG0719	Fe-S assembly protein
IQS21_RS13885	COG1376	ErfK ybiS ycfS ynhG family protein
IQS21_RS13890	COG4238	major outer membrane lipoprotein
IQS21_RS13895	COG0469	pyruvate kinase activity
IQS21_RS13905	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS13920	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS13925	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
IQS21_RS13935	COG4529	Protein conserved in bacteria
IQS21_RS13955	COG3468	outer membrane autotransporter barrel domain protein
IQS21_RS13965	COG0307	riboflavin synthase, alpha
IQS21_RS13970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IQS21_RS13975	COG2814	Major facilitator Superfamily
IQS21_RS13980	COG0583	DNA-binding transcription factor activity
IQS21_RS13995	COG2814	Major facilitator Superfamily
IQS21_RS14000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IQS21_RS14005	COG0791	NLP P60 protein
IQS21_RS14010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IQS21_RS14015	COG1201	RNA secondary structure unwinding
IQS21_RS14020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IQS21_RS14025	COG0346	lactoylglutathione lyase activity
IQS21_RS14030	COG1902	pentaerythritol trinitrate reductase activity
IQS21_RS14035	COG1309	transcriptional regulator
IQS21_RS14040	COG3313	Fe-S protein
IQS21_RS14045	COG4989	oxidoreductase activity
IQS21_RS14050	COG2032	superoxide dismutase activity
IQS21_RS14055	COG1289	transmembrane transporter activity
IQS21_RS14060	COG1566	PFAM secretion protein HlyD family protein
IQS21_RS14075	COG3133	Outer membrane lipoprotein
IQS21_RS14085	COG3895	Periplasmic Protein
IQS21_RS14100	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IQS21_RS14105	COG0625	glutathione transferase activity
IQS21_RS14110	COG3104	oligopeptide transport
IQS21_RS14115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IQS21_RS14125	COG4659	FMN binding
IQS21_RS14165	COG0673	inositol 2-dehydrogenase activity
IQS21_RS14175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IQS21_RS14180	COG1263	PTS System
IQS21_RS14180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS14185	COG1609	Transcriptional regulator
IQS21_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS14195	COG1309	transcriptional regulator
IQS21_RS14200	COG3250	beta-galactosidase activity
IQS21_RS14215	COG5339	Protein conserved in bacteria
IQS21_RS14220	COG1482	cell wall glycoprotein biosynthetic process
IQS21_RS14225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IQS21_RS14225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IQS21_RS14230	COG0114	fumarate hydratase activity
IQS21_RS14240	COG2205	protein histidine kinase activity
IQS21_RS14245	COG0745	RESPONSE REGULATOR receiver
IQS21_RS14250	COG3136	membrane protein required for alginate biosynthesis
IQS21_RS14260	COG0531	amino acid
IQS21_RS14270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IQS21_RS14275	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IQS21_RS14280	COG0628	permease
IQS21_RS14295	COG3591	Belongs to the peptidase S1B family
IQS21_RS14310	COG2814	Major facilitator Superfamily
IQS21_RS14315	COG0583	DNA-binding transcription factor activity
IQS21_RS14320	COG1940	carbohydrate kinase activity
IQS21_RS14325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IQS21_RS14335	COG3381	protein complex oligomerization
IQS21_RS14340	COG3302	dmso reductase anchor subunit
IQS21_RS14345	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS14350	COG0243	molybdopterin cofactor binding
IQS21_RS14355	COG0243	molybdopterin cofactor binding
IQS21_RS14370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IQS21_RS14390	COG1063	alcohol dehydrogenase
IQS21_RS14400	COG0582	viral genome integration into host DNA
IQS21_RS14435	COG1396	sequence-specific DNA binding
IQS21_RS14450	COG1846	Transcriptional regulator
IQS21_RS14465	COG4372	Transposase
IQS21_RS14470	COG3436	PFAM IS66 Orf2 family protein
IQS21_RS14485	COG2801	Transposase and inactivated derivatives
IQS21_RS14500	COG3077	Addiction module antitoxin, RelB DinJ family
IQS21_RS14505	COG2026	Addiction module toxin, RelE StbE family
IQS21_RS14525	COG1403	HNH endonuclease
IQS21_RS14530	COG0484	heat shock protein binding
IQS21_RS14550	COG3772	lysozyme
IQS21_RS14560	COG1278	Cold shock
IQS21_RS14585	COG5562	phage envelope protein
IQS21_RS14595	COG4220	transposase activity
IQS21_RS14615	COG1030	water channel activity
IQS21_RS14665	COG1196	nuclear chromosome segregation
IQS21_RS14710	COG5301	cellulose 1,4-beta-cellobiosidase activity
IQS21_RS14715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IQS21_RS14720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IQS21_RS14740	COG0246	Mannitol dehydrogenase
IQS21_RS14750	COG1802	Transcriptional regulator
IQS21_RS14755	COG4221	oxidoreductase activity
IQS21_RS14760	COG0339	signal peptide processing
IQS21_RS14765	COG1546	Belongs to the CinA family
IQS21_RS14770	COG3111	PFAM Bacterial OB fold (BOF) protein
IQS21_RS14775	COG3706	GGDEF domain
IQS21_RS14785	COG2814	Major facilitator Superfamily
IQS21_RS14800	COG4977	sequence-specific DNA binding
IQS21_RS14805	COG1846	Transcriptional regulator
IQS21_RS14825	COG0583	DNA-binding transcription factor activity
IQS21_RS14830	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS14835	COG2066	Belongs to the glutaminase family
IQS21_RS14855	COG3781	membrane
IQS21_RS14915	COG1396	sequence-specific DNA binding
IQS21_RS14920	COG3550	peptidyl-serine autophosphorylation
IQS21_RS14935	COG3539	Fimbrial protein
IQS21_RS14940	COG3539	Fimbrial protein
IQS21_RS14945	COG3539	Fimbrial protein
IQS21_RS14950	COG0243	molybdopterin cofactor binding
IQS21_RS14960	COG2207	Transcriptional regulator
IQS21_RS14965	COG3119	arylsulfatase activity
IQS21_RS14970	COG0641	radical SAM
IQS21_RS14980	COG4178	(ABC) transporter
IQS21_RS14985	COG4771	TonB-dependent receptor
IQS21_RS14990	COG0612	Peptidase, M16
IQS21_RS14995	COG0076	glutamate decarboxylase activity
IQS21_RS15000	COG0531	amino acid
IQS21_RS15005	COG1649	PFAM Uncharacterised BCR, COG1649
IQS21_RS15015	COG3706	GGDEF domain
IQS21_RS15020	COG2202	Pas domain
IQS21_RS15020	COG2200	EAL domain
IQS21_RS15020	COG2199	diguanylate cyclase activity
IQS21_RS15025	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IQS21_RS15030	COG0747	negative chemotaxis
IQS21_RS15035	COG0601	transmembrane transport
IQS21_RS15040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQS21_RS15045	COG0444	Belongs to the ABC transporter superfamily
IQS21_RS15050	COG4608	Belongs to the ABC transporter superfamily
IQS21_RS15055	COG1764	response to oxidative stress
IQS21_RS15075	COG1064	alcohol dehydrogenase
IQS21_RS15080	COG3093	addiction module antidote protein HigA
IQS21_RS15085	COG2864	formate dehydrogenase
IQS21_RS15090	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS15100	COG0697	spore germination
IQS21_RS15105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IQS21_RS15115	COG2223	nitrite transmembrane transporter activity
IQS21_RS15120	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IQS21_RS15125	COG1140	nitrate reductase beta subunit
IQS21_RS15130	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IQS21_RS15135	COG2181	nitrate reductase activity
IQS21_RS15140	COG0384	phenazine biosynthesis protein PhzF
IQS21_RS15145	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IQS21_RS15150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IQS21_RS15160	COG5433	transposase activity
IQS21_RS15180	COG3209	COG3209 Rhs family protein
IQS21_RS15195	COG0625	glutathione transferase activity
IQS21_RS15200	COG1113	amino acid transport
IQS21_RS15205	COG3391	amine dehydrogenase activity
IQS21_RS15210	COG4772	TonB-dependent receptor
IQS21_RS15220	COG2130	NADP-dependent
IQS21_RS15225	COG1247	-acetyltransferase
IQS21_RS15230	COG3238	Protein conserved in bacteria
IQS21_RS15255	COG1177	transmembrane transport
IQS21_RS15260	COG1176	ABC-type spermidine putrescine transport system, permease component I
IQS21_RS15265	COG3842	ATPase activity
IQS21_RS15270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IQS21_RS15275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IQS21_RS15280	COG1598	PFAM Uncharacterised protein family UPF0150
IQS21_RS15285	COG1724	mRNA binding
IQS21_RS15295	COG0826	peptidase U32
IQS21_RS15300	COG1396	sequence-specific DNA binding
IQS21_RS15305	COG3135	benzoate transporter
IQS21_RS15310	COG0675	Transposase, IS605 OrfB family
IQS21_RS15325	COG0500	methyltransferase
IQS21_RS15330	COG1275	C4-dicarboxylate transporter malic acid transport protein
IQS21_RS15335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IQS21_RS15340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IQS21_RS15345	COG2841	Protein conserved in bacteria
IQS21_RS15355	COG5383	Protein conserved in bacteria
IQS21_RS15360	COG0583	DNA-binding transcription factor activity
IQS21_RS15365	COG0840	transmembrane signaling receptor activity
IQS21_RS15380	COG3038	cytochrome b561
IQS21_RS15390	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS15395	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IQS21_RS15400	COG1643	Atp-dependent helicase
IQS21_RS15410	COG0671	phosphoesterase, PA-phosphatase related
IQS21_RS15410	COG2453	phosphatase
IQS21_RS15415	COG2267	carboxylic ester hydrolase activity
IQS21_RS15420	COG4589	Belongs to the CDS family
IQS21_RS15425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IQS21_RS15435	COG0667	Aldo Keto reductase
IQS21_RS15460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IQS21_RS15465	COG3327	negative regulation of DNA-templated transcription, initiation
IQS21_RS15470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IQS21_RS15475	COG0183	Belongs to the thiolase family
IQS21_RS15480	COG2050	protein possibly involved in aromatic compounds catabolism
IQS21_RS15485	COG1250	3-hydroxyacyl-CoA dehydrogenase
IQS21_RS15490	COG1024	Enoyl-CoA hydratase
IQS21_RS15495	COG1024	Enoyl-CoA hydratase
IQS21_RS15500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQS21_RS15505	COG2151	metal-sulfur cluster biosynthetic enzyme
IQS21_RS15510	COG3396	Phenylacetate-CoA oxygenase
IQS21_RS15515	COG3460	Phenylacetate-CoA oxygenase
IQS21_RS15520	COG3396	Phenylacetate-CoA oxygenase
IQS21_RS15525	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS15525	COG2030	dehydratase
IQS21_RS15530	COG3733	amine oxidase
IQS21_RS15535	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS15540	COG2207	Transcriptional regulator
IQS21_RS15545	COG3784	Protein of unknown function (DUF1318)
IQS21_RS15555	COG2911	Protein conserved in bacteria
IQS21_RS15560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IQS21_RS15565	COG3187	Heat shock protein
IQS21_RS15570	COG3042	response to heat
IQS21_RS15575	COG1013	pyruvate-flavodoxin oxidoreductase activity
IQS21_RS15575	COG0674	pyruvate-flavodoxin oxidoreductase activity
IQS21_RS15575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IQS21_RS15575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IQS21_RS15580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IQS21_RS15585	COG0589	response to stress
IQS21_RS15595	COG0513	Belongs to the DEAD box helicase family
IQS21_RS15605	COG3706	GGDEF domain
IQS21_RS15610	COG2840	Smr protein MutS2
IQS21_RS15615	COG0583	DNA-binding transcription factor activity
IQS21_RS15620	COG1473	amidohydrolase
IQS21_RS15635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IQS21_RS15640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQS21_RS15645	COG0589	response to stress
IQS21_RS15650	COG3182	Iron-regulated membrane protein
IQS21_RS15655	COG0668	transmembrane transport
IQS21_RS15660	COG4166	transmembrane transport
IQS21_RS15665	COG0583	DNA-binding transcription factor activity
IQS21_RS15670	COG1073	alpha beta
IQS21_RS15680	COG2866	Carboxypeptidase
IQS21_RS15685	COG4948	Mandelate Racemase Muconate Lactonizing
IQS21_RS15690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IQS21_RS15695	COG3283	Transcriptional regulator of aromatic amino acids metabolism
IQS21_RS15705	COG3106	COG3106 Predicted ATPase
IQS21_RS15710	COG1609	Transcriptional regulator
IQS21_RS15720	COG3842	ATPase activity
IQS21_RS15725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IQS21_RS15730	COG1554	hydrolase, family 65, central catalytic
IQS21_RS15735	COG0673	inositol 2-dehydrogenase activity
IQS21_RS15740	COG1082	Xylose isomerase domain protein TIM barrel
IQS21_RS15745	COG1063	alcohol dehydrogenase
IQS21_RS15750	COG0395	ABC-type sugar transport system, permease component
IQS21_RS15755	COG1175	transmembrane transport
IQS21_RS15760	COG1653	transport
IQS21_RS15765	COG0366	Alpha amylase catalytic
IQS21_RS15770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IQS21_RS15780	COG1983	PspC domain protein
IQS21_RS15790	COG1842	Phage shock protein A
IQS21_RS15795	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IQS21_RS15800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IQS21_RS15805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IQS21_RS15810	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS15815	COG1917	Cupin 2, conserved barrel domain protein
IQS21_RS15815	COG1396	sequence-specific DNA binding
IQS21_RS15820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IQS21_RS15825	COG0174	glutamine synthetase
IQS21_RS15835	COG0531	amino acid
IQS21_RS15845	COG4166	transmembrane transport
IQS21_RS15850	COG4168	peptide transport system, permease
IQS21_RS15855	COG4171	peptide transport system, permease
IQS21_RS15860	COG4172	Belongs to the ABC transporter superfamily
IQS21_RS15865	COG4172	Belongs to the ABC transporter superfamily
IQS21_RS15870	COG2852	Protein conserved in bacteria
IQS21_RS15875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IQS21_RS15880	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IQS21_RS15880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IQS21_RS15895	COG5001	Diguanylate cyclase
IQS21_RS15905	COG1349	DNA-binding transcription factor activity
IQS21_RS15915	COG0023	Translation Initiation Factor
IQS21_RS15925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IQS21_RS15930	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IQS21_RS15935	COG0671	phosphoesterase, PA-phosphatase related
IQS21_RS15945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IQS21_RS15970	COG0583	DNA-binding transcription factor activity
IQS21_RS15975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IQS21_RS15985	COG0616	signal peptide processing
IQS21_RS15990	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS15995	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IQS21_RS16000	COG1187	pseudouridine synthase activity
IQS21_RS16005	COG4907	membrane protein (DUF2207)
IQS21_RS16010	COG0009	L-threonylcarbamoyladenylate synthase
IQS21_RS16015	COG0613	PHP domain protein
IQS21_RS16025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IQS21_RS16030	COG0512	Glutamine amidotransferase of anthranilate synthase
IQS21_RS16030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IQS21_RS16035	COG0134	indole-3-glycerol-phosphate synthase activity
IQS21_RS16035	COG0135	phosphoribosylanthranilate isomerase activity
IQS21_RS16050	COG3729	General stress protein
IQS21_RS16055	COG3685	Protein conserved in bacteria
IQS21_RS16060	COG3685	Protein conserved in bacteria
IQS21_RS16065	COG3047	cAMP biosynthetic process
IQS21_RS16085	COG1607	acyl-coa hydrolase
IQS21_RS16090	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IQS21_RS16095	COG2350	Protein conserved in bacteria
IQS21_RS16100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IQS21_RS16120	COG4608	Belongs to the ABC transporter superfamily
IQS21_RS16125	COG0444	Belongs to the ABC transporter superfamily
IQS21_RS16130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQS21_RS16135	COG0601	transmembrane transport
IQS21_RS16140	COG4166	transmembrane transport
IQS21_RS16150	COG2095	MarC family integral membrane protein
IQS21_RS16155	COG1012	belongs to the aldehyde dehydrogenase family
IQS21_RS16155	COG1454	alcohol dehydrogenase
IQS21_RS16165	COG1435	thymidine kinase activity
IQS21_RS16175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IQS21_RS16180	COG0745	RESPONSE REGULATOR receiver
IQS21_RS16185	COG1752	Esterase of the alpha-beta hydrolase superfamily
IQS21_RS16195	COG0788	formyltetrahydrofolate deformylase activity
IQS21_RS16230	COG2181	nitrate reductase activity
IQS21_RS16235	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IQS21_RS16240	COG1140	nitrate reductase beta subunit
IQS21_RS16245	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IQS21_RS16250	COG2223	nitrite transmembrane transporter activity
IQS21_RS16255	COG3850	Histidine kinase
IQS21_RS16260	COG2197	response regulator
IQS21_RS16265	COG4932	domain protein
IQS21_RS16270	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IQS21_RS16275	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IQS21_RS16280	COG4572	Cation transport regulator
IQS21_RS16285	COG0387	Pfam Sodium calcium exchanger
IQS21_RS16310	COG2912	Transglutaminase-like superfamily
IQS21_RS16315	COG3094	Invasion gene expression up-regulator, SirB
IQS21_RS16320	COG2890	protein-(glutamine-N5) methyltransferase activity
IQS21_RS16345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IQS21_RS16350	COG0659	secondary active sulfate transmembrane transporter activity
IQS21_RS16365	COG0012	GTP binding
IQS21_RS16370	COG3468	outer membrane autotransporter barrel domain protein
IQS21_RS16375	COG3284	Transcriptional regulator
IQS21_RS16380	COG2376	Dihydroxyacetone kinase
IQS21_RS16385	COG1461	Dihydroxyacetone kinase
IQS21_RS16390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS16390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IQS21_RS16390	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IQS21_RS16405	COG2261	transglycosylase associated protein
IQS21_RS16410	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IQS21_RS16420	COG1619	proteins homologs of microcin C7 resistance protein MccF
IQS21_RS16430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IQS21_RS16440	COG2719	SpoVR family
IQS21_RS16455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IQS21_RS16460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IQS21_RS16465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IQS21_RS16480	COG0179	Fumarylacetoacetate (FAA) hydrolase
IQS21_RS16505	COG2894	cell division
IQS21_RS16555	COG2200	EAL domain
IQS21_RS16580	COG2200	EAL domain
IQS21_RS16585	COG0789	Transcriptional regulator
IQS21_RS16590	COG5562	phage envelope protein
IQS21_RS16610	COG0538	isocitrate dehydrogenase activity
IQS21_RS16615	COG1187	pseudouridine synthase activity
IQS21_RS16635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IQS21_RS16640	COG0745	RESPONSE REGULATOR receiver
IQS21_RS16645	COG2205	protein histidine kinase activity
IQS21_RS16650	COG2850	peptidyl-arginine hydroxylation
IQS21_RS16660	COG3842	ATPase activity
IQS21_RS16670	COG1177	transmembrane transport
IQS21_RS16675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IQS21_RS16685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IQS21_RS16690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IQS21_RS16700	COG4591	ABC-type transport system involved in lipoprotein release permease component
IQS21_RS16705	COG1136	(ABC) transporter
IQS21_RS16710	COG4591	ABC-type transport system involved in lipoprotein release permease component
IQS21_RS16715	COG4763	Acyl-transferase
IQS21_RS16720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IQS21_RS16725	COG1388	LysM domain
IQS21_RS16725	COG1376	ErfK ybiS ycfS ynhG family protein
IQS21_RS16735	COG1309	transcriptional regulator
IQS21_RS16740	COG3134	Outer membrane lipoprotein
IQS21_RS16745	COG1252	NADH dehydrogenase
IQS21_RS16765	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
IQS21_RS16770	COG5633	Lipoprotein
IQS21_RS16775	COG0537	adenosine 5'-monophosphoramidase activity
IQS21_RS16780	COG4773	Receptor
IQS21_RS16785	COG1263	PTS System
IQS21_RS16785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS16790	COG0084	hydrolase, TatD family'
IQS21_RS16795	COG0470	DNA polymerase III
IQS21_RS16805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IQS21_RS16810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IQS21_RS16815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IQS21_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS16830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IQS21_RS16850	COG1399	metal-binding, possibly nucleic acid-binding protein
IQS21_RS16855	COG0424	maF-like protein
IQS21_RS16860	COG0564	pseudouridine synthase activity
IQS21_RS16865	COG1530	ribonuclease E activity
IQS21_RS16870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IQS21_RS16875	COG1256	bacterial-type flagellum assembly
IQS21_RS16880	COG1705	Flagellar rod assembly protein muramidase FlgJ
IQS21_RS16880	COG3951	Flagellar rod assembly protein muramidase FlgJ
IQS21_RS16895	COG4786	Flagellar basal body rod
IQS21_RS16900	COG4787	bacterial-type flagellum-dependent cell motility
IQS21_RS16905	COG1749	Flagellar hook protein flgE
IQS21_RS16910	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IQS21_RS16915	COG1558	bacterial-type flagellum-dependent cell motility
IQS21_RS16920	COG1815	bacterial-type flagellum-dependent cell motility
IQS21_RS16925	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IQS21_RS16930	COG2747	anti-sigma28 factor FlgM
IQS21_RS16935	COG3418	PFAM FlgN family protein
IQS21_RS16940	COG0728	peptidoglycan biosynthetic process
IQS21_RS16945	COG0673	inositol 2-dehydrogenase activity
IQS21_RS16955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IQS21_RS16965	COG2999	glutathione oxidoreductase activity
IQS21_RS17000	COG3038	cytochrome b561
IQS21_RS17005	COG2353	YceI-like domain
IQS21_RS17015	COG1560	Kdo2-lipid A biosynthetic process
IQS21_RS17030	COG5645	(Lipo)protein
IQS21_RS17035	COG2943	transferase activity, transferring hexosyl groups
IQS21_RS17050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IQS21_RS17055	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IQS21_RS17080	COG2197	response regulator
IQS21_RS17095	COG1462	curli production assembly transport component CsgG
IQS21_RS17105	COG3381	protein complex oligomerization
IQS21_RS17145	COG3706	GGDEF domain
IQS21_RS17150	COG0457	Tetratricopeptide repeat
IQS21_RS17155	COG1649	PFAM Uncharacterised BCR, COG1649
IQS21_RS17155	COG0726	polysaccharide deacetylase
IQS21_RS17160	COG1215	transferase activity, transferring glycosyl groups
IQS21_RS17165	COG3658	cytochrome
IQS21_RS17170	COG1702	phosphate starvation-inducible protein PhoH
IQS21_RS17175	COG2837	iron assimilation
IQS21_RS17180	COG2822	iron ion transport
IQS21_RS17190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IQS21_RS17200	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IQS21_RS17200	COG0506	proline dehydrogenase activity
IQS21_RS17200	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IQS21_RS17205	COG1309	transcriptional regulator
IQS21_RS17240	COG2233	PERMEase
IQS21_RS17245	COG3729	General stress protein
IQS21_RS17280	COG3381	protein complex oligomerization
IQS21_RS17285	COG0243	molybdopterin cofactor binding
IQS21_RS17290	COG3005	denitrification pathway
IQS21_RS17295	COG0745	RESPONSE REGULATOR receiver
IQS21_RS17300	COG1879	ABC-type sugar transport system periplasmic component
IQS21_RS17305	COG0784	Response regulator, receiver
IQS21_RS17305	COG2198	Histidine kinase
IQS21_RS17305	COG2205	protein histidine kinase activity
IQS21_RS17310	COG0348	domain, Protein
IQS21_RS17330	COG1278	Cold shock
IQS21_RS17335	COG1278	Cold shock
IQS21_RS17355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IQS21_RS17360	COG1596	polysaccharide export
IQS21_RS17365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IQS21_RS17370	COG0489	protein tyrosine kinase activity
IQS21_RS17370	COG3206	protein involved in exopolysaccharide biosynthesis
IQS21_RS17385	COG1294	oxidase, subunit
IQS21_RS17390	COG1271	oxidase subunit
IQS21_RS17395	COG1773	rubredoxin
IQS21_RS17400	COG1999	signal sequence binding
IQS21_RS17405	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IQS21_RS17410	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
IQS21_RS17415	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IQS21_RS17420	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IQS21_RS17430	COG0670	Belongs to the BI1 family
IQS21_RS17435	COG2920	part of a sulfur-relay system
IQS21_RS17440	COG1254	Belongs to the acylphosphatase family
IQS21_RS17455	COG1832	CoA-binding protein
IQS21_RS17470	COG0210	DNA helicase
IQS21_RS17475	COG3304	Inner membrane component domain
IQS21_RS17480	COG1289	transmembrane transporter activity
IQS21_RS17485	COG3070	regulator of competence-specific genes
IQS21_RS17495	COG2885	chlorophyll binding
IQS21_RS17495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IQS21_RS17505	COG1067	ATP-dependent peptidase activity
IQS21_RS17515	COG3130	regulation of translation
IQS21_RS17520	COG3009	Protein conserved in bacteria
IQS21_RS17525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IQS21_RS17525	COG3008	intermembrane lipid transfer
IQS21_RS17530	COG2995	paraquat-inducible protein a
IQS21_RS17535	COG0488	(ABC) transporter
IQS21_RS17545	COG3217	Mosc domain protein beta barrel domain protein
IQS21_RS17545	COG0633	Ferredoxin
IQS21_RS17560	COG3121	Chaperone
IQS21_RS17565	COG3539	Fimbrial protein
IQS21_RS17570	COG3539	Fimbrial protein
IQS21_RS17575	COG3539	Fimbrial protein
IQS21_RS17580	COG3188	usher protein
IQS21_RS17585	COG3121	Chaperone
IQS21_RS17590	COG3539	Fimbrial protein
IQS21_RS17595	COG0431	NADPH-dependent FMN reductase
IQS21_RS17600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IQS21_RS17610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQS21_RS17615	COG1116	anion transmembrane transporter activity
IQS21_RS17620	COG0308	aminopeptidase N
IQS21_RS17640	COG1448	Aminotransferase
IQS21_RS17645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IQS21_RS17650	COG3108	Peptidase M15
IQS21_RS17655	COG2989	Protein conserved in bacteria
IQS21_RS17665	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IQS21_RS17675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IQS21_RS17680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IQS21_RS17685	COG3173	Aminoglycoside phosphotransferase
IQS21_RS17700	COG3214	Protein conserved in bacteria
IQS21_RS17705	COG1663	tetraacyldisaccharide 4'-kinase activity
IQS21_RS17710	COG1132	(ABC) transporter
IQS21_RS17715	COG2333	competence protein COMEC
IQS21_RS17715	COG0658	competence protein
IQS21_RS17725	COG0539	negative regulation of cytoplasmic translation
IQS21_RS17735	COG0501	Belongs to the peptidase M48B family
IQS21_RS17750	COG2323	membrane
IQS21_RS17755	COG1944	ATP diphosphatase activity
IQS21_RS17760	COG2116	formate transmembrane transporter activity
IQS21_RS17765	COG1882	Formate acetyltransferase
IQS21_RS17770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IQS21_RS17775	COG2249	NAD(P)H dehydrogenase (quinone) activity
IQS21_RS17780	COG0583	DNA-binding transcription factor activity
IQS21_RS17785	COG0531	amino acid
IQS21_RS17795	COG1335	isochorismatase
IQS21_RS17800	COG3302	dmso reductase anchor subunit
IQS21_RS17805	COG0437	4 iron, 4 sulfur cluster binding
IQS21_RS17810	COG0243	molybdopterin cofactor binding
IQS21_RS17820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IQS21_RS17830	COG1178	ABC-type Fe3 transport system permease component
IQS21_RS17830	COG1674	ftsk spoiiie
IQS21_RS17835	COG1522	sequence-specific DNA binding
IQS21_RS17840	COG0492	ferredoxin-NADP+ reductase activity
IQS21_RS17845	COG4988	ABC transporter
IQS21_RS17850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IQS21_RS17870	COG0542	response to heat
IQS21_RS17880	COG1278	Cold shock
IQS21_RS17885	COG1136	(ABC) transporter
IQS21_RS17885	COG0577	efflux transmembrane transporter activity
IQS21_RS17890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS17895	COG2990	Protein conserved in bacteria
IQS21_RS17900	COG3593	DNA synthesis involved in DNA repair
IQS21_RS17910	COG2431	L-lysine efflux transmembrane transporter activity
IQS21_RS17920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IQS21_RS17925	COG0028	Belongs to the TPP enzyme family
IQS21_RS17930	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IQS21_RS17935	COG0702	epimerase
IQS21_RS17940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IQS21_RS17945	COG3023	N-Acetylmuramoyl-L-alanine amidase
IQS21_RS17960	COG1126	abc transporter atp-binding protein
IQS21_RS17965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS17970	COG4215	(ABC) transporter
IQS21_RS17975	COG4160	amino acid transport
IQS21_RS17980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS17995	COG1177	transmembrane transport
IQS21_RS18000	COG1176	ABC-type spermidine putrescine transport system, permease component I
IQS21_RS18005	COG3842	ATPase activity
IQS21_RS18010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IQS21_RS18025	COG0778	Nitroreductase
IQS21_RS18035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IQS21_RS18050	COG3226	Transcriptional regulator
IQS21_RS18055	COG0738	Major facilitator superfamily
IQS21_RS18060	COG0561	phosphatase activity
IQS21_RS18070	COG2814	Major facilitator Superfamily
IQS21_RS18075	COG0671	phosphoesterase, PA-phosphatase related
IQS21_RS18080	COG1349	DNA-binding transcription factor activity
IQS21_RS18085	COG1686	Belongs to the peptidase S11 family
IQS21_RS18090	COG0625	glutathione transferase activity
IQS21_RS18095	COG2133	pyrroloquinoline quinone binding
IQS21_RS18110	COG2199	diguanylate cyclase activity
IQS21_RS18115	COG2200	EAL domain
IQS21_RS18120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IQS21_RS18130	COG0747	negative chemotaxis
IQS21_RS18135	COG4172	Belongs to the ABC transporter superfamily
IQS21_RS18140	COG1446	asparaginase
IQS21_RS18145	COG0303	'Molybdopterin
IQS21_RS18150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IQS21_RS18155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IQS21_RS18160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IQS21_RS18165	COG1882	Formate acetyltransferase
IQS21_RS18170	COG0561	phosphatase activity
IQS21_RS18180	COG0488	(ABC) transporter
IQS21_RS18185	COG1376	ErfK ybiS ycfS ynhG family protein
IQS21_RS18190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IQS21_RS18195	COG1321	iron dependent repressor
IQS21_RS18205	COG2194	sulfuric ester hydrolase activity
IQS21_RS18210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IQS21_RS18220	COG5006	permease, DMT superfamily
IQS21_RS18230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS18235	COG0765	amino acid transport
IQS21_RS18240	COG1126	abc transporter atp-binding protein
IQS21_RS18245	COG0668	transmembrane transport
IQS21_RS18260	COG4774	siderophore transport
IQS21_RS18270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IQS21_RS18280	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IQS21_RS18285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IQS21_RS18290	COG1199	ATP-dependent helicase activity
IQS21_RS18295	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
IQS21_RS18300	COG0513	Belongs to the DEAD box helicase family
IQS21_RS18305	COG1309	transcriptional regulator
IQS21_RS18315	COG1131	(ABC) transporter
IQS21_RS18320	COG0842	Transport permease protein
IQS21_RS18325	COG0842	Transport permease protein
IQS21_RS18335	COG3568	Endonuclease Exonuclease Phosphatase
IQS21_RS18340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IQS21_RS18345	COG0392	lysyltransferase activity
IQS21_RS18350	COG0670	Belongs to the BI1 family
IQS21_RS18355	COG0670	Belongs to the BI1 family
IQS21_RS18360	COG0314	molybdopterin synthase activity
IQS21_RS18365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IQS21_RS18375	COG0521	Mo-molybdopterin cofactor biosynthetic process
IQS21_RS18385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IQS21_RS18395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IQS21_RS18400	COG2226	methyltransferase
IQS21_RS18415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IQS21_RS18420	COG1881	PFAM PEBP family protein
IQS21_RS18425	COG4677	pectinesterase activity
IQS21_RS18430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IQS21_RS18435	COG0471	metal ion transport
IQS21_RS18440	COG2828	Protein conserved in bacteria
IQS21_RS18445	COG0583	DNA-binding transcription factor activity
IQS21_RS18455	COG0561	phosphatase activity
IQS21_RS18460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IQS21_RS18465	COG4149	molybdate abc transporter
IQS21_RS18470	COG0725	ABC transporter, periplasmic molybdate-binding protein
IQS21_RS18480	COG2005	Transcriptional regulator
IQS21_RS18480	COG3585	molybdate ion transport
IQS21_RS18485	COG1119	ATPase activity
IQS21_RS18490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IQS21_RS18495	COG1085	galactose-1-phosphate uridylyltransferase
IQS21_RS18505	COG2017	converts alpha-aldose to the beta-anomer
IQS21_RS18515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IQS21_RS18525	COG1230	cation diffusion facilitator family transporter
IQS21_RS18530	COG3201	nicotinamide mononucleotide transporter
IQS21_RS18580	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IQS21_RS18585	COG2885	chlorophyll binding
IQS21_RS18595	COG3064	Membrane
IQS21_RS18600	COG0848	biopolymer transport protein
IQS21_RS18605	COG0811	peptide transport
IQS21_RS18610	COG0824	Thioesterase
IQS21_RS18615	COG3790	cyd operon protein YbgE
IQS21_RS18620	COG4890	Cyd operon protein YbgT
IQS21_RS18625	COG1294	oxidase, subunit
IQS21_RS18630	COG1271	oxidase subunit
IQS21_RS18640	COG0383	alpha-mannosidase activity
IQS21_RS18645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS18645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IQS21_RS18645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS18650	COG2188	Transcriptional regulator
IQS21_RS18655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IQS21_RS18665	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQS21_RS18670	COG0567	Dehydrogenase, E1 component
IQS21_RS18675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IQS21_RS18680	COG1053	succinate dehydrogenase
IQS21_RS18685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IQS21_RS18690	COG2009	succinate dehydrogenase
IQS21_RS18700	COG0372	Belongs to the citrate synthase family
IQS21_RS18705	COG3539	Fimbrial protein
IQS21_RS18710	COG3188	usher protein
IQS21_RS18715	COG3121	Chaperone
IQS21_RS18720	COG3539	Fimbrial protein
IQS21_RS18725	COG3180	Ammonia monooxygenase
IQS21_RS18740	COG1984	allophanate hydrolase subunit 2
IQS21_RS18745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IQS21_RS18750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IQS21_RS18755	COG3104	oligopeptide transport
IQS21_RS18760	COG0415	Belongs to the DNA photolyase family
IQS21_RS18765	COG3272	Protein of unknown function (DUF1722)
IQS21_RS18810	COG3209	COG3209 Rhs family protein
IQS21_RS18840	COG2205	protein histidine kinase activity
IQS21_RS18845	COG0745	RESPONSE REGULATOR receiver
IQS21_RS18860	COG0531	amino acid
IQS21_RS18880	COG0033	Phosphoglucomutase
IQS21_RS18885	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IQS21_RS18890	COG0596	Alpha beta hydrolase
IQS21_RS18900	COG0716	FMN binding
IQS21_RS18910	COG0735	belongs to the Fur family
IQS21_RS18930	COG2190	(PTS) system
IQS21_RS18930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IQS21_RS18930	COG1263	PTS System
IQS21_RS18940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IQS21_RS18945	COG1846	Transcriptional regulator
IQS21_RS18945	COG1940	carbohydrate kinase activity
IQS21_RS18950	COG0647	UMP catabolic process
IQS21_RS18955	COG0367	asparagine synthase
IQS21_RS18995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IQS21_RS19005	COG1702	phosphate starvation-inducible protein PhoH
IQS21_RS19015	COG4535	Mg2 and Co2 transporter CorC
IQS21_RS19020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IQS21_RS19025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IQS21_RS19030	COG0765	amino acid transport
IQS21_RS19035	COG0765	amino acid transport
IQS21_RS19040	COG1126	abc transporter atp-binding protein
IQS21_RS19050	COG0443	Heat shock 70 kDa protein
IQS21_RS19055	COG2214	Heat shock protein DnaJ domain protein
IQS21_RS19065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IQS21_RS19070	COG2214	Heat shock protein DnaJ domain protein
IQS21_RS19080	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IQS21_RS19085	COG2888	peptidyl-tyrosine sulfation
IQS21_RS19100	COG1466	dna polymerase III delta subunit
IQS21_RS19110	COG0406	alpha-ribazole phosphatase activity
IQS21_RS19115	COG0799	negative regulation of ribosome biogenesis
IQS21_RS19125	COG0768	penicillin binding
IQS21_RS19130	COG0772	Belongs to the SEDS family
IQS21_RS19135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IQS21_RS19140	COG1686	Belongs to the peptidase S11 family
IQS21_RS19155	COG0583	DNA-binding transcription factor activity
IQS21_RS19165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IQS21_RS19190	COG3069	C4-dicarboxylate transmembrane transporter activity
IQS21_RS19195	COG4565	transcriptional regulatory protein
IQS21_RS19200	COG3290	protein histidine kinase activity
IQS21_RS19205	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IQS21_RS19215	COG2301	Belongs to the HpcH HpaI aldolase family
IQS21_RS19220	COG3051	citrate lyase alpha subunit
IQS21_RS19235	COG0471	metal ion transport
IQS21_RS19240	COG3719	Belongs to the RNase T2 family
IQS21_RS19245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IQS21_RS19250	COG1063	alcohol dehydrogenase
IQS21_RS19255	COG0589	response to stress
IQS21_RS19260	COG3634	alkyl hydroperoxide reductase activity
IQS21_RS19265	COG0450	alkyl hydroperoxide reductase
IQS21_RS19270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IQS21_RS19275	COG0583	DNA-binding transcription factor activity
IQS21_RS19280	COG3969	phosphoadenosine phosphosulfate
IQS21_RS19285	COG1475	DNA binding
IQS21_RS19290	COG0436	Aminotransferase
IQS21_RS19295	COG0371	Dehydrogenase
IQS21_RS19300	COG2879	small protein
IQS21_RS19305	COG1966	Carbon starvation protein
IQS21_RS19310	COG2050	protein possibly involved in aromatic compounds catabolism
IQS21_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
IQS21_RS19320	COG3433	isochorismatase activity
IQS21_RS19320	COG1535	isochorismatase
IQS21_RS19325	COG1021	2,3-dihydroxybenzoate-AMP ligase
IQS21_RS19330	COG1169	isochorismate synthase
IQS21_RS19335	COG4592	Periplasmic binding protein
IQS21_RS19345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQS21_RS19350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQS21_RS19355	COG1120	ATPase activity
IQS21_RS19360	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IQS21_RS19365	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IQS21_RS19365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IQS21_RS19370	COG3251	PFAM MbtH domain protein
IQS21_RS19375	COG2382	esterase
IQS21_RS19385	COG4771	TonB-dependent receptor
IQS21_RS19390	COG2977	Belongs to the P-Pant transferase superfamily
IQS21_RS19395	COG3385	transposase activity
IQS21_RS19430	COG3423	Transcriptional regulator
IQS21_RS19450	COG0500	methyltransferase
IQS21_RS19455	COG0438	transferase activity, transferring glycosyl groups
IQS21_RS19460	COG0438	transferase activity, transferring glycosyl groups
IQS21_RS19500	COG0778	Nitroreductase
IQS21_RS19505	COG0668	transmembrane transport
IQS21_RS19510	COG1113	amino acid transport
IQS21_RS19515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQS21_RS19520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS19525	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS19535	COG0745	RESPONSE REGULATOR receiver
IQS21_RS19540	COG5002	protein histidine kinase activity
IQS21_RS19545	COG1215	transferase activity, transferring glycosyl groups
IQS21_RS19550	COG4783	chaperone-mediated protein folding
IQS21_RS19560	COG2207	Transcriptional regulator
IQS21_RS19570	COG2197	response regulator
IQS21_RS19575	COG3539	Fimbrial protein
IQS21_RS19580	COG3539	Fimbrial protein
IQS21_RS19595	COG3539	Fimbrial protein
IQS21_RS19605	COG2501	S4 domain
IQS21_RS19610	COG1988	membrane-bound metal-dependent
IQS21_RS19620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IQS21_RS19630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IQS21_RS19635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IQS21_RS19640	COG0549	Belongs to the carbamate kinase family
IQS21_RS19650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IQS21_RS19660	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IQS21_RS19665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IQS21_RS19670	COG3257	ureidoglycine aminohydrolase activity
IQS21_RS19675	COG1929	Belongs to the glycerate kinase type-1 family
IQS21_RS19680	COG2233	PERMEase
IQS21_RS19690	COG1953	Uracil, thiamine, allantoin
IQS21_RS19695	COG2084	Dehydrogenase
IQS21_RS19700	COG3622	Belongs to the hyi family
IQS21_RS19705	COG3960	tartronate-semialdehyde synthase activity
IQS21_RS19710	COG1414	Transcriptional regulator
IQS21_RS19720	COG0583	DNA-binding transcription factor activity
IQS21_RS19745	COG3209	COG3209 Rhs family protein
IQS21_RS19760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IQS21_RS19765	COG4181	ATPase activity
IQS21_RS19770	COG2755	lipolytic protein G-D-S-L family
IQS21_RS19775	COG0300	oxidoreductase activity
IQS21_RS19780	COG3118	belongs to the thioredoxin family
IQS21_RS19785	COG0390	transport system, permease component
IQS21_RS19790	COG4619	ABC transporter
IQS21_RS19795	COG0330	HflC and HflK could
IQS21_RS19800	COG1585	Membrane protein implicated in regulation of membrane protease activity
IQS21_RS19805	COG0789	Transcriptional regulator
IQS21_RS19810	COG0531	amino acid
IQS21_RS19815	COG2066	Belongs to the glutaminase family
IQS21_RS19820	COG2217	Heavy metal translocating P-type atpase
IQS21_RS19825	COG3093	addiction module antidote protein HigA
IQS21_RS19830	COG3735	TraB family
IQS21_RS19835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IQS21_RS19840	COG0737	Belongs to the 5'-nucleotidase family
IQS21_RS19845	COG2223	nitrite transmembrane transporter activity
IQS21_RS19850	COG4651	solute:proton antiporter activity
IQS21_RS19850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IQS21_RS19855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IQS21_RS19890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IQS21_RS19900	COG2832	Protein of unknown function (DUF454)
IQS21_RS19905	COG3923	Primosomal replication protein n
IQS21_RS19915	COG3264	Mechanosensitive ion channel
IQS21_RS19915	COG1196	nuclear chromosome segregation
IQS21_RS19920	COG1309	transcriptional regulator
IQS21_RS19925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS19930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IQS21_RS19945	COG0110	maltose O-acetyltransferase activity
IQS21_RS19955	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IQS21_RS19960	COG5507	3-demethylubiquinone-9 3-methyltransferase
IQS21_RS19970	COG3695	enzyme binding
IQS21_RS19975	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IQS21_RS19980	COG1946	Acyl-CoA thioesterase
IQS21_RS19985	COG0004	ammonium transporteR
IQS21_RS19990	COG0347	Belongs to the P(II) protein family
IQS21_RS19995	COG1132	(ABC) transporter
IQS21_RS20000	COG1132	(ABC) transporter
IQS21_RS20005	COG1522	sequence-specific DNA binding
IQS21_RS20015	COG4533	DNA binding
IQS21_RS20025	COG0824	Thioesterase
IQS21_RS20030	COG1555	photosystem II stabilization
IQS21_RS20035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IQS21_RS20040	COG0776	regulation of translation
IQS21_RS20045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IQS21_RS20065	COG0271	Belongs to the BolA IbaG family
IQS21_RS20070	COG3056	Lipoprotein
IQS21_RS20075	COG2223	nitrite transmembrane transporter activity
IQS21_RS20080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IQS21_RS20085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IQS21_RS20090	COG1845	cytochrome c oxidase, subunit III
IQS21_RS20095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IQS21_RS20105	COG2814	Major facilitator Superfamily
IQS21_RS20115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IQS21_RS20120	COG0693	protein deglycase activity
IQS21_RS20135	COG0142	geranyltranstransferase activity
IQS21_RS20145	COG0667	Aldo Keto reductase
IQS21_RS20150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IQS21_RS20155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IQS21_RS20170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IQS21_RS20170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IQS21_RS20180	COG4238	major outer membrane lipoprotein
IQS21_RS20185	COG3248	Nucleoside-binding outer membrane protein
IQS21_RS20190	COG1403	HNH endonuclease
IQS21_RS20195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IQS21_RS20200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IQS21_RS20205	COG1862	Preprotein translocase
IQS21_RS20225	COG0366	Alpha amylase catalytic
IQS21_RS20230	COG1113	amino acid transport
IQS21_RS20235	COG1114	Component of the transport system for branched-chain amino acids
IQS21_RS20240	COG5002	protein histidine kinase activity
IQS21_RS20245	COG0745	RESPONSE REGULATOR receiver
IQS21_RS20250	COG0420	3'-5' exonuclease activity
IQS21_RS20255	COG0419	ATPase involved in DNA repair
IQS21_RS20260	COG2814	Major facilitator Superfamily
IQS21_RS20265	COG1940	carbohydrate kinase activity
IQS21_RS20290	COG4126	flavin adenine dinucleotide binding
IQS21_RS20310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IQS21_RS20315	COG3706	GGDEF domain
IQS21_RS20325	COG1785	Belongs to the alkaline phosphatase family
IQS21_RS20340	COG1181	Belongs to the D-alanine--D-alanine ligase family
IQS21_RS20360	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IQS21_RS20365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IQS21_RS20370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IQS21_RS20380	COG0113	porphobilinogen synthase activity
IQS21_RS20385	COG2175	clavaminate synthase activity
IQS21_RS20390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IQS21_RS20400	COG4521	taurine ABC transporter
IQS21_RS20405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IQS21_RS20410	COG1215	transferase activity, transferring glycosyl groups
IQS21_RS20440	COG3122	Protein conserved in bacteria
IQS21_RS20445	COG2814	Major facilitator Superfamily
IQS21_RS20460	COG3971	2-oxopent-4-enoate hydratase activity
IQS21_RS20480	COG1414	Transcriptional regulator
IQS21_RS20485	COG1609	Transcriptional regulator
IQS21_RS20490	COG3250	beta-galactosidase activity
IQS21_RS20495	COG2223	nitrite transmembrane transporter activity
IQS21_RS20500	COG0110	maltose O-acetyltransferase activity
IQS21_RS20505	COG2807	transmembrane transport
IQS21_RS20515	COG0288	reversible hydration of carbon dioxide
IQS21_RS20520	COG0583	DNA-binding transcription factor activity
IQS21_RS20525	COG0402	S-adenosylhomocysteine deaminase activity
IQS21_RS20530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IQS21_RS20535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IQS21_RS20540	COG2079	MmgE PrpD family protein
IQS21_RS20545	COG0372	Belongs to the citrate synthase family
IQS21_RS20550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IQS21_RS20555	COG3829	transcription factor binding
IQS21_RS20565	COG1280	lysine exporter protein (LysE YggA)
IQS21_RS20580	COG1064	alcohol dehydrogenase
IQS21_RS20585	COG0402	S-adenosylhomocysteine deaminase activity
IQS21_RS20590	COG0549	Belongs to the carbamate kinase family
IQS21_RS20600	COG1304	FMN binding
IQS21_RS20605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IQS21_RS20615	COG0666	response to abiotic stimulus
IQS21_RS20625	COG0583	DNA-binding transcription factor activity
IQS21_RS20630	COG2200	EAL domain
IQS21_RS20630	COG2771	luxR family
IQS21_RS20640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IQS21_RS20665	COG1556	Lactate utilization protein
IQS21_RS20670	COG1139	Iron-sulfur cluster binding protein
IQS21_RS20675	COG0247	lactate metabolic process
IQS21_RS20680	COG2207	Transcriptional regulator
IQS21_RS20685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IQS21_RS20695	COG3059	membrane
IQS21_RS20705	COG3708	Transcriptional regulator
IQS21_RS20705	COG2207	Transcriptional regulator
IQS21_RS20710	COG1388	LysM domain
IQS21_RS20750	COG3188	usher protein
IQS21_RS20760	COG3121	Chaperone
IQS21_RS20765	COG0727	PFAM Uncharacterised protein family (UPF0153)
IQS21_RS20770	COG3477	response to acidic pH
IQS21_RS20775	COG2080	2 iron, 2 sulfur cluster binding
IQS21_RS20780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IQS21_RS20785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IQS21_RS20790	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IQS21_RS20915	COG0582	viral genome integration into host DNA
IQS21_RS20935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IQS21_RS20955	COG2195	Cleaves the N-terminal amino acid of tripeptides
IQS21_RS20970	COG0454	-acetyltransferase
IQS21_RS20980	COG2161	toxin-antitoxin pair type II binding
IQS21_RS21000	COG1943	Transposase
IQS21_RS21005	COG0791	NLP P60 protein
IQS21_RS21010	COG3077	Addiction module antitoxin, RelB DinJ family
IQS21_RS21015	COG3041	Addiction module toxin RelE StbE family
IQS21_RS21020	COG3034	peptidoglycan biosynthetic process
IQS21_RS21025	COG0121	glutamine amidotransferase
IQS21_RS21035	COG1960	acyl-CoA dehydrogenase activity
IQS21_RS21045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IQS21_RS21050	COG5433	transposase activity
IQS21_RS21065	COG3209	COG3209 Rhs family protein
IQS21_RS21155	COG3157	Type VI secretion system effector, Hcp
IQS21_RS21160	COG4104	PAAR repeat-containing protein
IQS21_RS21180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IQS21_RS21190	COG2226	methyltransferase
IQS21_RS21200	COG1388	LysM domain
IQS21_RS21200	COG0741	lytic transglycosylase activity
IQS21_RS21215	COG0583	DNA-binding transcription factor activity
IQS21_RS21220	COG0656	L-ascorbic acid biosynthetic process
IQS21_RS21255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IQS21_RS21260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IQS21_RS21265	COG2011	ABC-type metal ion transport system permease component
IQS21_RS21270	COG1464	Belongs to the NlpA lipoprotein family
IQS21_RS21280	COG1720	tRNA m6t6A37 methyltransferase activity
IQS21_RS21290	COG0791	NLP P60 protein
IQS21_RS21295	COG3015	lipoprotein NlpE involved in copper resistance
IQS21_RS21300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IQS21_RS21305	COG4681	YaeQ
IQS21_RS21315	COG4568	rho-dependent transcription termination
IQS21_RS21320	COG0037	tRNA processing
IQS21_RS21325	COG0346	lactoylglutathione lyase activity
IQS21_RS21330	COG1982	Orn Lys Arg decarboxylase major
IQS21_RS21340	COG0587	DNA-directed DNA polymerase activity
IQS21_RS21365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IQS21_RS21370	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IQS21_RS21380	COG0750	zinc metalloprotease
IQS21_RS21385	COG0575	Belongs to the CDS family
IQS21_RS21390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IQS21_RS21395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IQS21_RS21420	COG0024	Methionine aminopeptidase
IQS21_RS21435	COG1408	metallophosphoesterase
IQS21_RS21445	COG3835	regulator
IQS21_RS21450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IQS21_RS21465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IQS21_RS21470	COG2860	membrane
IQS21_RS21495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IQS21_RS21500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IQS21_RS21505	COG1120	ATPase activity
IQS21_RS21510	COG4774	siderophore transport
IQS21_RS21515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IQS21_RS21520	COG1643	Atp-dependent helicase
IQS21_RS21525	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IQS21_RS21535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IQS21_RS21545	COG0617	tRNA 3'-terminal CCA addition
IQS21_RS21550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IQS21_RS21555	COG3539	Fimbrial protein
IQS21_RS21560	COG3121	Chaperone
IQS21_RS21565	COG3188	usher protein
IQS21_RS21570	COG3539	Fimbrial protein
IQS21_RS21575	COG3539	Fimbrial protein
IQS21_RS21580	COG3539	Fimbrial protein
IQS21_RS21585	COG3539	Fimbrial protein
IQS21_RS21600	COG5464	transposase or invertase
IQS21_RS21610	COG0726	polysaccharide deacetylase
IQS21_RS21615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IQS21_RS21620	COG0842	Transport permease protein
IQS21_RS21625	COG1131	(ABC) transporter
IQS21_RS21630	COG0288	reversible hydration of carbon dioxide
IQS21_RS21635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IQS21_RS21640	COG4993	Dehydrogenase
IQS21_RS21645	COG2132	Multicopper oxidase
IQS21_RS21670	COG1049	propionate catabolic process, 2-methylcitrate cycle
IQS21_RS21675	COG3064	Membrane
IQS21_RS21680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IQS21_RS21685	COG0508	dehydrogenase complex catalyzes the overall conversion of
IQS21_RS21690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IQS21_RS21695	COG2186	Transcriptional regulator
IQS21_RS21700	COG1113	amino acid transport
IQS21_RS21705	COG3725	Membrane protein required for beta-lactamase induction
IQS21_RS21710	COG3023	N-Acetylmuramoyl-L-alanine amidase
IQS21_RS21715	COG0157	Belongs to the NadC ModD family
IQS21_RS21720	COG4969	Belongs to the N-Me-Phe pilin family
IQS21_RS21730	COG1459	type II secretion system
IQS21_RS21745	COG0237	dephospho-CoA kinase activity
IQS21_RS21760	COG0494	nUDIX hydrolase
IQS21_RS21780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IQS21_RS21785	COG0849	cell division
IQS21_RS21790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IQS21_RS21795	COG1181	Belongs to the D-alanine--D-alanine ligase family
IQS21_RS21810	COG0772	Belongs to the SEDS family
IQS21_RS21815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IQS21_RS21825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IQS21_RS21830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IQS21_RS21835	COG0768	penicillin binding
IQS21_RS21840	COG3116	cell division
IQS21_RS21850	COG2001	Belongs to the MraZ family
IQS21_RS21855	COG1609	Transcriptional regulator
IQS21_RS21865	COG0440	acetolactate synthase activity
IQS21_RS21870	COG0028	Belongs to the TPP enzyme family
IQS21_RS21880	COG0583	DNA-binding transcription factor activity
IQS21_RS21895	COG0473	3-isopropylmalate dehydrogenase activity
IQS21_RS21910	COG2814	Major facilitator Superfamily
IQS21_RS21920	COG4533	DNA binding
IQS21_RS21925	COG4143	(ABC) transporter
IQS21_RS21930	COG1178	ABC-type Fe3 transport system permease component
IQS21_RS21935	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IQS21_RS21940	COG0586	Pfam SNARE associated Golgi protein
IQS21_RS21945	COG4977	sequence-specific DNA binding
IQS21_RS21950	COG1069	ribulokinase activity
IQS21_RS21955	COG2160	L-arabinose isomerase activity
IQS21_RS21960	COG0235	Class ii aldolase
IQS21_RS21965	COG0417	DNA replication proofreading
IQS21_RS21975	COG0564	pseudouridine synthase activity
IQS21_RS21995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IQS21_RS22000	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IQS21_RS22005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IQS21_RS22030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IQS21_RS22045	COG2271	Major facilitator Superfamily
IQS21_RS22050	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IQS21_RS22055	COG0644	oxidoreductase
IQS21_RS22105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IQS21_RS22110	COG0505	Belongs to the CarA family
IQS21_RS22130	COG1047	Peptidyl-prolyl cis-trans
IQS21_RS22145	COG0196	riboflavin kinase activity
IQS21_RS22175	COG3188	usher protein
IQS21_RS22185	COG0583	DNA-binding transcription factor activity
IQS21_RS22215	COG4735	regulation of single-species biofilm formation
IQS21_RS22220	COG1584	GPR1 FUN34 yaaH family protein
IQS21_RS22225	COG0521	Mo-molybdopterin cofactor biosynthetic process
IQS21_RS22235	COG1115	amino acid carrier protein
IQS21_RS22250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IQS21_RS22260	COG0527	aspartate kinase activity
IQS21_RS22260	COG0460	homoserine dehydrogenase
IQS21_RS22270	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IQS21_RS22280	COG0745	RESPONSE REGULATOR receiver
IQS21_RS22285	COG4452	Inner membrane protein CreD
IQS21_RS22290	COG2205	protein histidine kinase activity
IQS21_RS22295	COG0745	RESPONSE REGULATOR receiver
IQS21_RS22300	COG3045	CreA protein
IQS21_RS22305	COG3708	Transcriptional regulator
IQS21_RS22305	COG2207	Transcriptional regulator
IQS21_RS22325	COG0741	lytic transglycosylase activity
IQS21_RS22330	COG0488	(ABC) transporter
IQS21_RS22335	COG3172	ATPase kinase involved in NAD metabolism
IQS21_RS22335	COG1056	cytidyltransferase-related domain
IQS21_RS22340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IQS21_RS22345	COG0560	Phosphoserine phosphatase
IQS21_RS22350	COG3726	membrane protein affecting hemolysin expression
IQS21_RS22360	COG3550	peptidyl-serine autophosphorylation
IQS21_RS22385	COG1328	CTP reductase activity
IQS21_RS22390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IQS21_RS22395	COG0084	hydrolase, TatD family'
IQS21_RS22400	COG4667	esterase of the alpha-beta hydrolase superfamily
IQS21_RS22410	COG2823	Periplasmic or secreted lipoprotein
IQS21_RS22420	COG1011	Hydrolase
IQS21_RS22425	COG0456	acetyltransferase
IQS21_RS22430	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IQS21_RS22460	COG4114	ferric iron reductase
IQS21_RS22465	COG2197	response regulator
IQS21_RS22470	COG2197	response regulator
IQS21_RS22475	COG2966	Psort location CytoplasmicMembrane, score
IQS21_RS22490	COG1484	DNA-dependent DNA replication
IQS21_RS22505	COG1063	alcohol dehydrogenase
IQS21_RS22515	COG1802	Transcriptional regulator
IQS21_RS22520	COG2271	Major facilitator Superfamily
IQS21_RS22525	COG0840	transmembrane signaling receptor activity
IQS21_RS22530	COG1966	Carbon starvation protein
IQS21_RS22535	COG2879	small protein
IQS21_RS22540	COG0523	cobalamin synthesis protein
IQS21_RS22565	COG2814	Major facilitator Superfamily
IQS21_RS22570	COG2733	membrane
IQS21_RS22575	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IQS21_RS22580	COG1924	4 iron, 4 sulfur cluster binding
IQS21_RS22595	COG0477	Major facilitator Superfamily
IQS21_RS22605	COG3366	ferrous iron transmembrane transporter activity
IQS21_RS22610	COG0700	Nucleoside recognition
IQS21_RS22615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IQS21_RS22620	COG0583	DNA-binding transcription factor activity
IQS21_RS22640	COG2186	Transcriptional regulator
IQS21_RS22645	COG0246	Mannitol dehydrogenase
IQS21_RS22655	COG2610	gluconate transmembrane transporter activity
IQS21_RS22660	COG3539	Fimbrial protein
IQS21_RS22665	COG3539	Fimbrial protein
IQS21_RS22670	COG3539	Fimbrial protein
IQS21_RS22675	COG3188	usher protein
IQS21_RS22680	COG3121	Chaperone
IQS21_RS22685	COG3539	Fimbrial protein
IQS21_RS22695	COG4974	Belongs to the 'phage' integrase family
IQS21_RS22700	COG0582	viral genome integration into host DNA
IQS21_RS22705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IQS21_RS22710	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IQS21_RS22735	COG1401	restriction endodeoxyribonuclease activity
IQS21_RS22795	COG2003	Belongs to the UPF0758 family
IQS21_RS22820	COG3596	GTP binding
IQS21_RS22965	COG1475	DNA binding
IQS21_RS23085	COG3436	PFAM IS66 Orf2 family protein
IQS21_RS23170	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IQS21_RS23180	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IQS21_RS23190	COG1196	nuclear chromosome segregation
IQS21_RS23200	COG2194	sulfuric ester hydrolase activity
IQS21_RS23205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IQS21_RS23345	COG1783	phage Terminase large subunit
IQS21_RS23365	COG3646	Phage regulatory protein
IQS21_RS23550	COG0582	viral genome integration into host DNA
IQS21_RS23715	COG1121	(ABC) transporter
IQS21_RS23735	COG0431	NADPH-dependent FMN reductase
IQS21_RS23770	COG0697	spore germination
IQS21_RS23790	COG3436	PFAM IS66 Orf2 family protein
IQS21_RS23795	COG4372	Transposase
IQS21_RS23810	COG0739	heme binding
IQS21_RS23840	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IQS21_RS23915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family