locus-tag	class	description
A4R38_RS00005	COG0235	Class ii aldolase
A4R38_RS00025	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS00030	COG3037	sugar-specific permease SgaT UlaA
A4R38_RS00045	COG1073	alpha beta
A4R38_RS00050	COG3650	response to hydrogen peroxide
A4R38_RS00055	COG1662	PFAM IS1 transposase
A4R38_RS00060	COG3677	Transposase
A4R38_RS00060	COG1662	PFAM IS1 transposase
A4R38_RS00070	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS00075	COG0754	glutathionylspermidine amidase activity
A4R38_RS00080	COG5463	Belongs to the UPF0441 family
A4R38_RS00085	COG3766	membrane
A4R38_RS00095	COG1842	Phage shock protein A
A4R38_RS00100	COG3789	protein conserved in bacteria
A4R38_RS00105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R38_RS00110	COG0557	exoribonuclease II activity
A4R38_RS00125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A4R38_RS00130	COG0330	HflC and HflK could
A4R38_RS00135	COG0330	HflC and HflK could
A4R38_RS00140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4R38_RS00160	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS00165	COG0802	atpase or kinase
A4R38_RS00170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4R38_RS00170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4R38_RS00175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4R38_RS00210	COG1511	domain protein
A4R38_RS00210	COG3264	Mechanosensitive ion channel
A4R38_RS00220	COG0531	amino acid
A4R38_RS00230	COG1053	succinate dehydrogenase
A4R38_RS00235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R38_RS00250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R38_RS00255	COG3040	lipid binding
A4R38_RS00260	COG2076	Multidrug Resistance protein
A4R38_RS00265	COG5510	response to toxic substance
A4R38_RS00270	COG5510	response to toxic substance
A4R38_RS00280	COG1509	lysine 2,3-aminomutase activity
A4R38_RS00305	COG0531	amino acid
A4R38_RS00310	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4R38_RS00315	COG1027	Aspartate ammonia-lyase
A4R38_RS00320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4R38_RS00330	COG4232	protein-disulfide reductase activity
A4R38_RS00335	COG1309	transcriptional regulator
A4R38_RS00345	COG3710	Transcriptional regulator
A4R38_RS00350	COG0531	amino acid
A4R38_RS00355	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS00360	COG3104	oligopeptide transport
A4R38_RS00365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4R38_RS00380	COG2388	GCN5-related N-acetyl-transferase
A4R38_RS00395	COG3210	domain, Protein
A4R38_RS00395	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS00405	COG3121	Chaperone
A4R38_RS00415	COG2388	GCN5-related N-acetyl-transferase
A4R38_RS00420	COG3592	Divergent 4Fe-4S mono-cluster
A4R38_RS00425	COG3290	protein histidine kinase activity
A4R38_RS00430	COG4565	transcriptional regulatory protein
A4R38_RS00440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4R38_RS00445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS00445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS00450	COG3647	Membrane
A4R38_RS00455	COG1486	melibiose metabolic process
A4R38_RS00465	COG2169	Transcriptional regulator
A4R38_RS00470	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS00475	COG2207	Transcriptional regulator
A4R38_RS00480	COG0531	amino acid
A4R38_RS00485	COG2194	sulfuric ester hydrolase activity
A4R38_RS00490	COG0745	RESPONSE REGULATOR receiver
A4R38_RS00495	COG0642	Histidine kinase
A4R38_RS00505	COG0477	Major facilitator Superfamily
A4R38_RS00520	COG2824	Alkylphosphonate utilization operon protein PhnA
A4R38_RS00525	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A4R38_RS00535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A4R38_RS00540	COG3639	organic phosphonate transmembrane transporter activity
A4R38_RS00545	COG2188	Transcriptional regulator
A4R38_RS00550	COG3624	Phosphonate C-P lyase system protein PhnG
A4R38_RS00555	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A4R38_RS00560	COG3626	phosphonate metabolism
A4R38_RS00565	COG3627	carbon phosphorus lyase activity
A4R38_RS00570	COG4107	phosphonate C-P lyase system protein PhnK
A4R38_RS00575	COG4778	phosphonate C-P lyase system protein PhnL
A4R38_RS00580	COG3454	Phosphonate metabolism
A4R38_RS00590	COG0456	acetyltransferase
A4R38_RS00595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4R38_RS00605	COG0698	ribose 5-phosphate isomerase
A4R38_RS00610	COG1737	Transcriptional regulator
A4R38_RS00615	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS00620	COG1129	ABC transporter
A4R38_RS00625	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS00630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4R38_RS00635	COG1940	carbohydrate kinase activity
A4R38_RS00640	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A4R38_RS00650	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS00655	COG1289	transmembrane transporter activity
A4R38_RS00665	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS00670	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS00680	COG0601	transmembrane transport
A4R38_RS00685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS00690	COG0444	Belongs to the ABC transporter superfamily
A4R38_RS00695	COG4608	Belongs to the ABC transporter superfamily
A4R38_RS00700	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A4R38_RS00705	COG1301	dicarboxylic acid transport
A4R38_RS00710	COG4235	cytochrome complex assembly
A4R38_RS00715	COG3088	subunit of a heme lyase
A4R38_RS00720	COG1138	Cytochrome C-type biogenesis protein
A4R38_RS00725	COG3301	Polysulphide reductase, NrfD
A4R38_RS00730	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS00735	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4R38_RS00745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R38_RS00750	COG3162	membrane
A4R38_RS00760	COG1346	cytolysis
A4R38_RS00765	COG1380	Effector of murein hydrolase LrgA
A4R38_RS00770	COG0583	DNA-binding transcription factor activity
A4R38_RS00775	COG0025	NhaP-type Na H and K H
A4R38_RS00780	COG2252	PERMEase
A4R38_RS00785	COG0789	Transcriptional regulator
A4R38_RS00790	COG2207	Transcriptional regulator
A4R38_RS00795	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4R38_RS00805	COG0629	single-stranded DNA binding
A4R38_RS00810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R38_RS00815	COG2315	Protein conserved in bacteria
A4R38_RS00820	COG0432	Pfam Uncharacterised protein family UPF0047
A4R38_RS00825	COG3700	Belongs to the class B bacterial acid phosphatase family
A4R38_RS00835	COG2204	response regulator
A4R38_RS00840	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS00845	COG0471	metal ion transport
A4R38_RS00850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS00855	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R38_RS00860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS00870	COG0567	Dehydrogenase, E1 component
A4R38_RS00875	COG1448	Aminotransferase
A4R38_RS00885	COG3201	nicotinamide mononucleotide transporter
A4R38_RS00890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4R38_RS00895	COG0305	Participates in initiation and elongation during chromosome replication
A4R38_RS00900	COG1609	Transcriptional regulator
A4R38_RS00910	COG1024	Enoyl-CoA hydratase
A4R38_RS00915	COG1914	H( )-stimulated, divalent metal cation uptake system
A4R38_RS00920	COG1053	succinate dehydrogenase
A4R38_RS00925	COG0604	alcohol dehydrogenase
A4R38_RS00935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4R38_RS00940	COG0735	belongs to the Fur family
A4R38_RS00945	COG3237	CsbD-like
A4R38_RS00950	COG0534	Mate efflux family protein
A4R38_RS00960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4R38_RS00990	COG3842	ATPase activity
A4R38_RS01000	COG2182	Extracellular solute-binding protein
A4R38_RS01005	COG1175	transmembrane transport
A4R38_RS01010	COG3833	ABC-type maltose transport systems, permease component
A4R38_RS01030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS01055	COG0527	aspartate kinase activity
A4R38_RS01065	COG1187	pseudouridine synthase activity
A4R38_RS01115	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4R38_RS01125	COG1410	methionine synthase
A4R38_RS01125	COG0646	methionine synthase
A4R38_RS01130	COG1414	Transcriptional regulator
A4R38_RS01140	COG2224	Isocitrate lyase
A4R38_RS01145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4R38_RS01155	COG0456	acetyltransferase
A4R38_RS01200	COG0151	Belongs to the GarS family
A4R38_RS01205	COG2204	response regulator
A4R38_RS01210	COG4191	Histidine kinase
A4R38_RS01215	COG3678	ATP-independent chaperone mediated protein folding
A4R38_RS01230	COG3068	Protein conserved in bacteria
A4R38_RS01265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4R38_RS01270	COG2104	thiamine diphosphate biosynthetic process
A4R38_RS01280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4R38_RS01315	COG0250	Participates in transcription elongation, termination and antitermination
A4R38_RS01320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4R38_RS01360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4R38_RS01360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4R38_RS01420	COG0477	Major facilitator Superfamily
A4R38_RS01425	COG1473	amidohydrolase
A4R38_RS01435	COG0583	DNA-binding transcription factor activity
A4R38_RS01450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4R38_RS01465	COG2194	sulfuric ester hydrolase activity
A4R38_RS01470	COG2207	Transcriptional regulator
A4R38_RS01475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS01485	COG1882	Formate acetyltransferase
A4R38_RS01490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS01505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R38_RS01510	COG0371	Dehydrogenase
A4R38_RS01520	COG3738	Protein conserved in bacteria
A4R38_RS01525	COG0697	spore germination
A4R38_RS01535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4R38_RS01540	COG0737	Belongs to the 5'-nucleotidase family
A4R38_RS01550	COG0527	aspartate kinase activity
A4R38_RS01550	COG0460	homoserine dehydrogenase
A4R38_RS01555	COG0626	cystathionine gamma-synthase activity
A4R38_RS01565	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A4R38_RS01575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4R38_RS01580	COG1609	Transcriptional regulator
A4R38_RS01585	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4R38_RS01600	COG1575	Belongs to the MenA family. Type 1 subfamily
A4R38_RS01615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4R38_RS01625	COG1494	fructose-1,6-bisphosphatase
A4R38_RS01635	COG0589	response to stress
A4R38_RS01640	COG3691	Protein conserved in bacteria
A4R38_RS01645	COG3152	Membrane
A4R38_RS01665	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A4R38_RS01680	COG3678	ATP-independent chaperone mediated protein folding
A4R38_RS01685	COG0745	RESPONSE REGULATOR receiver
A4R38_RS01690	COG2205	protein histidine kinase activity
A4R38_RS01695	COG2258	MOSC domain
A4R38_RS01710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4R38_RS01760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01770	COG1363	Peptidase, m42
A4R38_RS01775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01775	COG3711	transcriptional antiterminator
A4R38_RS01790	COG0326	Molecular chaperone. Has ATPase activity
A4R38_RS01800	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS01800	COG0243	molybdopterin cofactor binding
A4R38_RS01805	COG0243	molybdopterin cofactor binding
A4R38_RS01805	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS01810	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS01815	COG2864	formate dehydrogenase
A4R38_RS01825	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS01840	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS01870	COG0456	acetyltransferase
A4R38_RS01885	COG1011	Hydrolase
A4R38_RS01890	COG1349	DNA-binding transcription factor activity
A4R38_RS01895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS01900	COG2084	Dehydrogenase
A4R38_RS01905	COG3684	Belongs to the aldolase LacD family
A4R38_RS01910	COG2942	2-epimerase
A4R38_RS01915	COG2017	converts alpha-aldose to the beta-anomer
A4R38_RS01925	COG1501	Belongs to the glycosyl hydrolase 31 family
A4R38_RS01930	COG2211	Major facilitator Superfamily
A4R38_RS01935	COG2211	Major facilitator Superfamily
A4R38_RS01940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4R38_RS01945	COG1217	gtp-binding protein TYPA
A4R38_RS01955	COG0174	glutamine synthetase
A4R38_RS01960	COG3852	Histidine kinase
A4R38_RS01965	COG2204	response regulator
A4R38_RS01975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4R38_RS01990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4R38_RS01990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4R38_RS02000	COG0204	Acyl-transferase
A4R38_RS02005	COG5339	Protein conserved in bacteria
A4R38_RS02010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R38_RS02015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4R38_RS02020	COG3084	Protein conserved in bacteria
A4R38_RS02025	COG0746	molybdenum cofactor guanylyltransferase activity
A4R38_RS02030	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4R38_RS02055	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A4R38_RS02060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4R38_RS02065	COG1739	Uncharacterized protein family UPF0029
A4R38_RS02085	COG0543	2 iron, 2 sulfur cluster binding
A4R38_RS02090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4R38_RS02105	COG0805	protein transport
A4R38_RS02115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R38_RS02125	COG3165	ubiquinone biosynthetic process from chorismate
A4R38_RS02135	COG1322	Protein conserved in bacteria
A4R38_RS02140	COG1414	Transcriptional regulator
A4R38_RS02145	COG3734	2-keto-3-deoxy-galactonokinase
A4R38_RS02150	COG0800	Aldolase
A4R38_RS02170	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4R38_RS02175	COG0412	Dienelactone hydrolase
A4R38_RS02185	COG1335	isochorismatase
A4R38_RS02195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS02200	COG1304	FMN binding
A4R38_RS02205	COG0549	Belongs to the carbamate kinase family
A4R38_RS02215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4R38_RS02220	COG0583	DNA-binding transcription factor activity
A4R38_RS02225	COG1737	Transcriptional regulator
A4R38_RS02230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4R38_RS02235	COG2190	(PTS) system
A4R38_RS02235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS02235	COG1263	PTS System
A4R38_RS02250	COG0583	DNA-binding transcription factor activity
A4R38_RS02255	COG0697	spore germination
A4R38_RS02260	COG0561	phosphatase activity
A4R38_RS02265	COG2267	carboxylic ester hydrolase activity
A4R38_RS02270	COG1280	lysine exporter protein (LysE YggA)
A4R38_RS02280	COG1280	lysine exporter protein (LysE YggA)
A4R38_RS02285	COG0514	ATP-dependent DNA helicase (RecQ)
A4R38_RS02290	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A4R38_RS02295	COG2050	protein possibly involved in aromatic compounds catabolism
A4R38_RS02300	COG2962	Rard protein
A4R38_RS02315	COG0598	Magnesium transport protein CorA
A4R38_RS02325	COG3698	Phosphodiester glycosidase
A4R38_RS02330	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
A4R38_RS02335	COG0210	DNA helicase
A4R38_RS02340	COG1011	Hydrolase
A4R38_RS02350	COG3159	Protein conserved in bacteria
A4R38_RS02360	COG5567	small periplasmic lipoprotein
A4R38_RS02370	COG3072	Adenylate cyclase
A4R38_RS02380	COG1587	Uroporphyrinogen-III synthase
A4R38_RS02385	COG2959	enzyme of heme biosynthesis
A4R38_RS02390	COG3071	HemY protein
A4R38_RS02400	COG3119	arylsulfatase activity
A4R38_RS02405	COG0641	radical SAM
A4R38_RS02430	COG1113	amino acid transport
A4R38_RS02450	COG2244	polysaccharide biosynthetic process
A4R38_RS02455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R38_RS02460	COG0456	acetyltransferase
A4R38_RS02465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4R38_RS02470	COG1088	dTDP-glucose 4,6-dehydratase activity
A4R38_RS02475	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4R38_RS02480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4R38_RS02485	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4R38_RS02490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4R38_RS02500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4R38_RS02510	COG3118	belongs to the thioredoxin family
A4R38_RS02525	COG0210	DNA helicase
A4R38_RS02530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R38_RS02540	COG0583	DNA-binding transcription factor activity
A4R38_RS02545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R38_RS02555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R38_RS02560	COG3978	acetolactate synthase activity
A4R38_RS02575	COG0606	chelatase, subunit chli
A4R38_RS02580	COG3085	chromosome segregation
A4R38_RS02620	COG2186	Transcriptional regulator
A4R38_RS02625	COG0477	Major facilitator Superfamily
A4R38_RS02630	COG1609	Transcriptional regulator
A4R38_RS02635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS02640	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS02645	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS02650	COG1129	ABC transporter
A4R38_RS02655	COG1869	D-ribose catabolic process
A4R38_RS02680	COG1522	sequence-specific DNA binding
A4R38_RS02685	COG0716	FMN binding
A4R38_RS02700	COG3312	ion transport
A4R38_RS02755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4R38_RS02760	COG0573	inorganic phosphate transmembrane transporter activity
A4R38_RS02765	COG0581	inorganic phosphate transmembrane transporter activity
A4R38_RS02770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4R38_RS02775	COG0704	Plays a role in the regulation of phosphate uptake
A4R38_RS02780	COG3711	transcriptional antiterminator
A4R38_RS02785	COG2190	(PTS) system
A4R38_RS02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS02785	COG1263	PTS System
A4R38_RS02790	COG2723	6-phospho-beta-galactosidase activity
A4R38_RS02795	COG4580	involved in the transport of maltose and maltodextrins
A4R38_RS02800	COG2382	esterase
A4R38_RS02805	COG0363	glucosamine-6-phosphate deaminase activity
A4R38_RS02810	COG3196	Protein conserved in bacteria
A4R38_RS02820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS02825	COG2252	PERMEase
A4R38_RS02830	COG0431	NADPH-dependent FMN reductase
A4R38_RS02835	COG2091	lysine biosynthetic process via aminoadipic acid
A4R38_RS02840	COG0583	DNA-binding transcription factor activity
A4R38_RS02850	COG0814	amino acid
A4R38_RS02895	COG0592	DNA-directed DNA polymerase activity
A4R38_RS02905	COG0187	DNA topoisomerase II activity
A4R38_RS02915	COG3753	Protein conserved in bacteria
A4R38_RS02920	COG0561	phosphatase activity
A4R38_RS02930	COG2186	Transcriptional regulator
A4R38_RS02935	COG3734	2-keto-3-deoxy-galactonokinase
A4R38_RS02940	COG0800	Aldolase
A4R38_RS02950	COG2271	Major facilitator Superfamily
A4R38_RS02960	COG0823	Involved in the tonB-independent uptake of proteins
A4R38_RS02965	COG5645	(Lipo)protein
A4R38_RS02985	COG2207	Transcriptional regulator
A4R38_RS02990	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R38_RS02995	COG3119	arylsulfatase activity
A4R38_RS03000	COG2149	membrane
A4R38_RS03010	COG0641	radical SAM
A4R38_RS03015	COG2814	Major facilitator Superfamily
A4R38_RS03025	COG0028	Belongs to the TPP enzyme family
A4R38_RS03030	COG0440	acetolactate synthase activity
A4R38_RS03045	COG2197	response regulator
A4R38_RS03050	COG3851	Histidine kinase
A4R38_RS03055	COG2271	Major facilitator Superfamily
A4R38_RS03060	COG2271	Major facilitator Superfamily
A4R38_RS03070	COG2252	PERMEase
A4R38_RS03110	COG1464	Belongs to the NlpA lipoprotein family
A4R38_RS03115	COG0697	spore germination
A4R38_RS03160	COG2003	Belongs to the UPF0758 family
A4R38_RS03185	COG2020	methyltransferase activity
A4R38_RS03190	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS03200	COG4983	Phage plasmid primase, P4 family domain protein
A4R38_RS03250	COG4584	PFAM Integrase catalytic
A4R38_RS03255	COG1484	DNA-dependent DNA replication
A4R38_RS03310	COG3344	reverse transcriptase
A4R38_RS03335	COG0456	acetyltransferase
A4R38_RS03340	COG3039	Transposase
A4R38_RS03345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4R38_RS03365	COG2271	Major facilitator Superfamily
A4R38_RS03370	COG1609	Transcriptional regulator
A4R38_RS03380	COG0582	viral genome integration into host DNA
A4R38_RS03390	COG2211	Major facilitator Superfamily
A4R38_RS03395	COG1501	Belongs to the glycosyl hydrolase 31 family
A4R38_RS03400	COG3711	transcriptional antiterminator
A4R38_RS03405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS03410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03430	COG1940	carbohydrate kinase activity
A4R38_RS03440	COG2982	Protein involved in outer membrane biogenesis
A4R38_RS03445	COG2233	PERMEase
A4R38_RS03450	COG0786	glutamate:sodium symporter activity
A4R38_RS03455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4R38_RS03460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R38_RS03465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R38_RS03475	COG0194	GDP metabolic process
A4R38_RS03480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4R38_RS03485	COG2860	membrane
A4R38_RS03490	COG1561	YicC-like family, N-terminal region
A4R38_RS03515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4R38_RS03545	COG1519	Transferase
A4R38_RS03550	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03555	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS03560	COG0515	serine threonine protein kinase
A4R38_RS03565	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS03565	COG4641	Protein conserved in bacteria
A4R38_RS03570	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS03575	COG1442	glycosyl transferase family 8
A4R38_RS03580	COG1442	glycosyl transferase family 8
A4R38_RS03585	COG3642	lipopolysaccharide core region biosynthetic process
A4R38_RS03595	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03600	COG3307	-O-antigen
A4R38_RS03605	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03610	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03620	COG0156	8-amino-7-oxononanoate synthase activity
A4R38_RS03630	COG1216	Glycosyl transferase, family 2
A4R38_RS03635	COG2861	carbohydrate metabolic process
A4R38_RS03640	COG4942	peptidase
A4R38_RS03650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4R38_RS03655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4R38_RS03670	COG1045	serine acetyltransferase
A4R38_RS03675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4R38_RS03685	COG2186	Transcriptional regulator
A4R38_RS03690	COG1620	l-lactate permease
A4R38_RS03695	COG5295	Hep Hag repeat protein
A4R38_RS03715	COG3722	fumarate hydratase activity
A4R38_RS03725	COG2213	PTS system mannitol-specific
A4R38_RS03725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS03735	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS03740	COG0625	glutathione transferase activity
A4R38_RS03750	COG3276	selenocysteine insertion sequence binding
A4R38_RS03755	COG1454	alcohol dehydrogenase
A4R38_RS03765	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS03775	COG2211	Major facilitator Superfamily
A4R38_RS03785	COG0235	Class ii aldolase
A4R38_RS03790	COG3623	hexulose-6-phosphate isomerase
A4R38_RS03795	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4R38_RS03800	COG1070	Carbohydrate kinase
A4R38_RS03805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4R38_RS03810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4R38_RS03815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4R38_RS03825	COG2731	YhcH YjgK YiaL family protein
A4R38_RS03835	COG1414	Transcriptional regulator
A4R38_RS03840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS03845	COG3977	Valine--pyruvate aminotransferase
A4R38_RS03850	COG0366	Alpha amylase catalytic
A4R38_RS03855	COG2992	FlgJ-related protein
A4R38_RS03860	COG2207	Transcriptional regulator
A4R38_RS03860	COG1609	Transcriptional regulator
A4R38_RS03865	COG4214	carbohydrate transport
A4R38_RS03875	COG4213	ABC transporter substrate-binding protein
A4R38_RS03885	COG1070	Carbohydrate kinase
A4R38_RS03890	COG4682	membrane
A4R38_RS03895	COG4682	membrane
A4R38_RS03900	COG3274	enterobacterial common antigen metabolic process
A4R38_RS03920	COG2963	transposase activity
A4R38_RS03925	COG2801	Transposase and inactivated derivatives
A4R38_RS03935	COG1278	Cold shock
A4R38_RS03940	COG2944	sequence-specific DNA binding
A4R38_RS03955	COG2885	chlorophyll binding
A4R38_RS03960	COG0243	molybdopterin cofactor binding
A4R38_RS03965	COG0456	acetyltransferase
A4R38_RS03970	COG2818	Glycosylase
A4R38_RS03975	COG5571	outer membrane autotransporter
A4R38_RS03980	COG2223	nitrite transmembrane transporter activity
A4R38_RS03985	COG2194	sulfuric ester hydrolase activity
A4R38_RS04000	COG0747	negative chemotaxis
A4R38_RS04010	COG0601	transmembrane transport
A4R38_RS04015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS04020	COG0444	Belongs to the ABC transporter superfamily
A4R38_RS04025	COG4608	Belongs to the ABC transporter superfamily
A4R38_RS04035	COG3550	peptidyl-serine autophosphorylation
A4R38_RS04040	COG3550	peptidyl-serine autophosphorylation
A4R38_RS04045	COG0814	amino acid
A4R38_RS04095	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS04100	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS04105	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A4R38_RS04110	COG3118	belongs to the thioredoxin family
A4R38_RS04110	COG0457	Tetratricopeptide repeat
A4R38_RS04115	COG2200	EAL domain
A4R38_RS04115	COG2199	diguanylate cyclase activity
A4R38_RS04125	COG0612	Peptidase, M16
A4R38_RS04130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS04140	COG2200	EAL domain
A4R38_RS04145	COG2982	Protein involved in outer membrane biogenesis
A4R38_RS04150	COG0477	Major facilitator Superfamily
A4R38_RS04155	COG1295	ribonuclease BN
A4R38_RS04160	COG0583	DNA-binding transcription factor activity
A4R38_RS04165	COG2197	response regulator
A4R38_RS04175	COG1858	cytochrome C peroxidase
A4R38_RS04180	COG0076	glutamate decarboxylase activity
A4R38_RS04185	COG2207	Transcriptional regulator
A4R38_RS04190	COG2207	Transcriptional regulator
A4R38_RS04195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS04200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS04210	COG2771	luxR family
A4R38_RS04215	COG3247	response to pH
A4R38_RS04230	COG1285	pathogenesis
A4R38_RS04240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS04250	COG3721	Heme iron utilization protein
A4R38_RS04275	COG4771	TonB-dependent receptor
A4R38_RS04280	COG3720	iron ion transport
A4R38_RS04285	COG2197	response regulator
A4R38_RS04290	COG3065	identical protein binding
A4R38_RS04295	COG1393	Belongs to the ArsC family
A4R38_RS04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS04315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4R38_RS04320	COG0339	signal peptide processing
A4R38_RS04330	COG3104	oligopeptide transport
A4R38_RS04335	COG0589	response to stress
A4R38_RS04345	COG0306	phosphate transporter
A4R38_RS04350	COG2081	HI0933 family
A4R38_RS04360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS04365	COG1129	ABC transporter
A4R38_RS04365	COG0842	Transport permease protein
A4R38_RS04370	COG0842	Transport permease protein
A4R38_RS04375	COG0191	fructose-bisphosphate aldolase activity
A4R38_RS04390	COG3775	system Galactitol-specific IIC component
A4R38_RS04395	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS04405	COG2188	Transcriptional regulator
A4R38_RS04425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS04430	COG0601	transmembrane transport
A4R38_RS04435	COG0747	negative chemotaxis
A4R38_RS04440	COG2091	lysine biosynthetic process via aminoadipic acid
A4R38_RS04445	COG0628	permease
A4R38_RS04450	COG0477	Major facilitator Superfamily
A4R38_RS04460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4R38_RS04475	COG3714	YhhN family
A4R38_RS04485	COG3776	membrane
A4R38_RS04490	COG0742	ribosomal rna small subunit methyltransferase
A4R38_RS04495	COG0552	protein localization to endoplasmic reticulum
A4R38_RS04500	COG2884	Cell division ATP-binding protein ftsE
A4R38_RS04505	COG2177	Part of the ABC transporter FtsEX involved in
A4R38_RS04510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4R38_RS04515	COG0683	leucine binding
A4R38_RS04530	COG0456	acetyltransferase
A4R38_RS04535	COG0683	leucine binding
A4R38_RS04540	COG0559	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS04545	COG4177	L-phenylalanine transmembrane transporter activity
A4R38_RS04550	COG0411	ABC transporter
A4R38_RS04555	COG0410	ABC transporter
A4R38_RS04585	COG0584	glycerophosphoryl diester phosphodiesterase
A4R38_RS04595	COG0405	Gamma-glutamyltransferase
A4R38_RS04600	COG1247	-acetyltransferase
A4R38_RS04610	COG0673	inositol 2-dehydrogenase activity
A4R38_RS04615	COG1741	Belongs to the pirin family
A4R38_RS04620	COG1609	Transcriptional regulator
A4R38_RS04625	COG3265	gluconokinase activity
A4R38_RS04630	COG2610	gluconate transmembrane transporter activity
A4R38_RS04635	COG0514	ATP-dependent DNA helicase (RecQ)
A4R38_RS04645	COG2095	MarC family integral membrane protein
A4R38_RS04650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4R38_RS04675	COG0058	SHG alpha-glucan phosphorylase activity
A4R38_RS04680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4R38_RS04695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4R38_RS04710	COG1349	DNA-binding transcription factor activity
A4R38_RS04715	COG4650	regulator
A4R38_RS04730	COG0058	SHG alpha-glucan phosphorylase activity
A4R38_RS04735	COG1640	4-alpha-glucanotransferase
A4R38_RS04740	COG2610	gluconate transmembrane transporter activity
A4R38_RS04755	COG0596	Alpha beta hydrolase
A4R38_RS04760	COG5464	transposase or invertase
A4R38_RS04770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4R38_RS04775	COG1918	ferrous iron import across plasma membrane
A4R38_RS04780	COG2183	response to ionizing radiation
A4R38_RS04785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R38_RS04810	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4R38_RS04820	COG0675	Transposase, IS605 OrfB family
A4R38_RS04830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4R38_RS04835	COG1011	Hydrolase
A4R38_RS04845	COG0494	nUDIX hydrolase
A4R38_RS04850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4R38_RS04855	COG4972	Pilus assembly protein
A4R38_RS04860	COG3166	PFAM Fimbrial assembly family protein
A4R38_RS04875	COG4796	Type ii and iii secretion system protein
A4R38_RS04890	COG3266	domain, Protein
A4R38_RS04895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4R38_RS04900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4R38_RS04910	COG0180	Tryptophanyl-tRNA synthetase
A4R38_RS04915	COG2188	Transcriptional regulator
A4R38_RS04925	COG3457	Alanine racemase
A4R38_RS04930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A4R38_RS04935	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A4R38_RS04950	COG0626	cystathionine gamma-synthase activity
A4R38_RS04965	COG2116	formate transmembrane transporter activity
A4R38_RS04970	COG2146	nitrite reductase [NAD(P)H] activity
A4R38_RS04975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R38_RS04985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R38_RS04995	COG2184	nucleotidyltransferase activity
A4R38_RS05000	COG0512	Glutamine amidotransferase of anthranilate synthase
A4R38_RS05005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R38_RS05010	COG1289	transmembrane transporter activity
A4R38_RS05015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS05025	COG1765	OsmC-like protein
A4R38_RS05030	COG3954	Phosphoribulokinase
A4R38_RS05040	COG0429	hydrolase of the alpha beta-hydrolase fold
A4R38_RS05045	COG0488	(ABC) transporter
A4R38_RS05060	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A4R38_RS05065	COG1047	Peptidyl-prolyl cis-trans
A4R38_RS05075	COG0545	Peptidyl-prolyl cis-trans isomerase
A4R38_RS05080	COG2964	Protein conserved in bacteria
A4R38_RS05120	COG3979	chitinase
A4R38_RS05125	COG2906	2 iron, 2 sulfur cluster binding
A4R38_RS05130	COG2193	ferroxidase activity
A4R38_RS05135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4R38_RS05140	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A4R38_RS05145	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A4R38_RS05150	COG3156	type II secretion system protein K
A4R38_RS05155	COG4795	General secretion pathway protein
A4R38_RS05160	COG2165	general secretion pathway protein
A4R38_RS05165	COG2165	general secretion pathway protein
A4R38_RS05170	COG2165	general secretion pathway protein
A4R38_RS05175	COG1459	type II secretion system
A4R38_RS05180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4R38_RS05185	COG1450	Type ii and iii secretion system protein
A4R38_RS05190	COG3031	protein transport across the cell outer membrane
A4R38_RS05195	COG3409	Peptidoglycan-binding domain 1 protein
A4R38_RS05195	COG3267	Type II secretory pathway component ExeA
A4R38_RS05220	COG0089	rRNA binding
A4R38_RS05310	COG0201	protein transport
A4R38_RS05350	COG0789	Transcriptional regulator
A4R38_RS05355	COG3036	rescue of stalled ribosome
A4R38_RS05365	COG0569	domain protein
A4R38_RS05385	COG0758	DNA mediated transformation
A4R38_RS05395	COG0551	DNA topoisomerase type I activity
A4R38_RS05400	COG0009	L-threonylcarbamoyladenylate synthase
A4R38_RS05415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4R38_RS05455	COG1126	abc transporter atp-binding protein
A4R38_RS05460	COG0765	amino acid transport
A4R38_RS05465	COG4597	amino acid ABC transporter
A4R38_RS05470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS05485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS05490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS05495	COG1309	transcriptional regulator
A4R38_RS05505	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A4R38_RS05515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4R38_RS05525	COG4145	pantothenate transmembrane transporter activity
A4R38_RS05530	COG3924	membrane
A4R38_RS05535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS05540	COG1349	DNA-binding transcription factor activity
A4R38_RS05550	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS05555	COG1129	ABC transporter
A4R38_RS05560	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS05565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS05575	COG0439	Biotin carboxylase
A4R38_RS05580	COG0511	ligase activity, forming carbon-carbon bonds
A4R38_RS05595	COG0604	alcohol dehydrogenase
A4R38_RS05600	COG2200	EAL domain
A4R38_RS05600	COG2199	diguanylate cyclase activity
A4R38_RS05610	COG1077	Cell shape determining protein MreB Mrl
A4R38_RS05615	COG1792	Involved in formation and maintenance of cell shape
A4R38_RS05620	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4R38_RS05630	COG1530	ribonuclease E activity
A4R38_RS05635	COG3164	Protein of unknown function
A4R38_RS05640	COG0312	modulator of DNA gyrase
A4R38_RS05645	COG0583	DNA-binding transcription factor activity
A4R38_RS05665	COG2732	(Barnase) inhibitor
A4R38_RS05685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R38_RS05690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R38_RS05695	COG3105	Protein conserved in bacteria
A4R38_RS05700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A4R38_RS05715	COG0625	glutathione transferase activity
A4R38_RS05720	COG2969	positive regulation of protein catabolic process
A4R38_RS05735	COG2814	Major facilitator Superfamily
A4R38_RS05745	COG1940	carbohydrate kinase activity
A4R38_RS05750	COG2731	YhcH YjgK YiaL family protein
A4R38_RS05755	COG0493	'glutamate synthase
A4R38_RS05760	COG0070	glutamate synthase
A4R38_RS05760	COG0069	glutamate synthase activity
A4R38_RS05760	COG0067	glutamate synthase
A4R38_RS05765	COG1242	4 iron, 4 sulfur cluster binding
A4R38_RS05770	COG0784	Response regulator, receiver
A4R38_RS05770	COG2198	Histidine kinase
A4R38_RS05770	COG5002	protein histidine kinase activity
A4R38_RS05775	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A4R38_RS05785	COG0515	serine threonine protein kinase
A4R38_RS05790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS05805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4R38_RS05810	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A4R38_RS05815	COG1137	ATPase activity
A4R38_RS05820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4R38_RS05825	COG3117	lipopolysaccharide transmembrane transporter activity
A4R38_RS05830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4R38_RS05835	COG0517	IMP dehydrogenase activity
A4R38_RS05835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4R38_RS05840	COG0530	calcium, potassium:sodium antiporter activity
A4R38_RS05845	COG1127	ABC transporter
A4R38_RS05850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R38_RS05855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4R38_RS05860	COG2854	intermembrane phospholipid transfer
A4R38_RS05865	COG3113	response to antibiotic
A4R38_RS05870	COG5007	Belongs to the BolA IbaG family
A4R38_RS05880	COG3423	Transcriptional regulator
A4R38_RS05885	COG0142	geranyltranstransferase activity
A4R38_RS05900	COG0697	spore germination
A4R38_RS05910	COG2027	D-alanyl-D-alanine carboxypeptidase
A4R38_RS05915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R38_RS05920	COG1534	Rna-binding protein
A4R38_RS05930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R38_RS05935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4R38_RS05945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4R38_RS05960	COG2194	sulfuric ester hydrolase activity
A4R38_RS05980	COG0195	Participates in both transcription termination and antitermination
A4R38_RS06015	COG0513	Belongs to the DEAD box helicase family
A4R38_RS06025	COG0814	amino acid
A4R38_RS06030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R38_RS06035	COG0826	peptidase U32
A4R38_RS06040	COG0826	peptidase U32
A4R38_RS06045	COG3154	lipid carrier protein
A4R38_RS06050	COG3153	acetyltransferase
A4R38_RS06065	COG0693	protein deglycase activity
A4R38_RS06070	COG0702	epimerase
A4R38_RS06075	COG0701	Predicted permease
A4R38_RS06080	COG2823	Periplasmic or secreted lipoprotein
A4R38_RS06100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4R38_RS06105	COG0363	glucosamine-6-phosphate deaminase activity
A4R38_RS06110	COG3716	PTS system mannose fructose sorbose family IID component
A4R38_RS06115	COG3715	PTS system
A4R38_RS06120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS06130	COG2222	sugar isomerase
A4R38_RS06135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4R38_RS06140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS06145	COG3716	PTS system mannose fructose sorbose family IID component
A4R38_RS06155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS06165	COG1349	DNA-binding transcription factor activity
A4R38_RS06175	COG2002	toxin-antitoxin pair type II binding
A4R38_RS06180	COG2721	sulfolactate sulfo-lyase activity
A4R38_RS06185	COG2271	Major facilitator Superfamily
A4R38_RS06195	COG2084	Dehydrogenase
A4R38_RS06200	COG1929	Belongs to the glycerate kinase type-1 family
A4R38_RS06215	COG0583	DNA-binding transcription factor activity
A4R38_RS06220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R38_RS06230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4R38_RS06235	COG1882	Formate acetyltransferase
A4R38_RS06240	COG0251	oxidation-reduction process
A4R38_RS06245	COG1760	l-serine dehydratase
A4R38_RS06250	COG0814	amino acid
A4R38_RS06265	COG1741	Belongs to the pirin family
A4R38_RS06270	COG0583	DNA-binding transcription factor activity
A4R38_RS06275	COG3152	Membrane
A4R38_RS06285	COG0435	Glutathione S-transferase
A4R38_RS06290	COG2259	Doxx family
A4R38_RS06300	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A4R38_RS06305	COG4575	ribosome binding
A4R38_RS06310	COG1422	Protein of unknown function (DUF1090)
A4R38_RS06320	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS06325	COG2186	Transcriptional regulator
A4R38_RS06330	COG2271	Major facilitator Superfamily
A4R38_RS06340	COG2721	sulfolactate sulfo-lyase activity
A4R38_RS06355	COG0861	Integral membrane protein TerC family
A4R38_RS06360	COG0673	inositol 2-dehydrogenase activity
A4R38_RS06365	COG2949	membrane
A4R38_RS06370	COG1451	nucleotide metabolic process
A4R38_RS06385	COG4680	protein conserved in bacteria
A4R38_RS06390	COG5499	transcription regulator containing HTH domain
A4R38_RS06395	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4R38_RS06395	COG1902	pentaerythritol trinitrate reductase activity
A4R38_RS06400	COG3408	Glycogen debranching enzyme
A4R38_RS06400	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A4R38_RS06410	COG0531	amino acid
A4R38_RS06415	COG2731	YhcH YjgK YiaL family protein
A4R38_RS06420	COG3250	beta-galactosidase activity
A4R38_RS06425	COG1609	Transcriptional regulator
A4R38_RS06430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4R38_RS06440	COG0840	transmembrane signaling receptor activity
A4R38_RS06445	COG1695	Transcriptional regulator
A4R38_RS06450	COG2375	cellular response to nickel ion
A4R38_RS06465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4R38_RS06470	COG0358	DNA primase activity
A4R38_RS06475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4R38_RS06485	COG0471	metal ion transport
A4R38_RS06490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS06495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS06510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4R38_RS06525	COG4991	sh3 domain protein
A4R38_RS06535	COG3025	triphosphatase activity
A4R38_RS06555	COG2268	Band 7 protein
A4R38_RS06560	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4R38_RS06580	COG3539	Fimbrial protein
A4R38_RS06585	COG3121	Chaperone
A4R38_RS06590	COG3188	usher protein
A4R38_RS06595	COG3539	Fimbrial protein
A4R38_RS06610	COG3384	dioxygenase
A4R38_RS06620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4R38_RS06630	COG0754	glutathionylspermidine amidase activity
A4R38_RS06645	COG1538	Outer membrane efflux protein
A4R38_RS06650	COG0494	nUDIX hydrolase
A4R38_RS06655	COG3151	Protein conserved in bacteria
A4R38_RS06660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4R38_RS06665	COG3150	esterase
A4R38_RS06670	COG0187	DNA topoisomerase II activity
A4R38_RS06675	COG4774	siderophore transport
A4R38_RS06680	COG1120	ATPase activity
A4R38_RS06685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS06690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS06700	COG1737	Transcriptional regulator
A4R38_RS06705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4R38_RS06710	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4R38_RS06730	COG0642	Histidine kinase
A4R38_RS06735	COG0745	RESPONSE REGULATOR receiver
A4R38_RS06740	COG3111	PFAM Bacterial OB fold (BOF) protein
A4R38_RS06745	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4R38_RS06750	COG4166	transmembrane transport
A4R38_RS06755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4R38_RS06760	COG0204	Acyl-transferase
A4R38_RS06785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS06790	COG1063	alcohol dehydrogenase
A4R38_RS06795	COG0246	Mannitol dehydrogenase
A4R38_RS06800	COG2186	Transcriptional regulator
A4R38_RS06805	COG1032	radical SAM domain protein
A4R38_RS06810	COG4238	major outer membrane lipoprotein
A4R38_RS06820	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS06825	COG1979	alcohol dehydrogenase
A4R38_RS06835	COG2207	Transcriptional regulator
A4R38_RS06840	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS06845	COG0626	cystathionine gamma-synthase activity
A4R38_RS06855	COG0811	peptide transport
A4R38_RS06860	COG0848	biopolymer transport protein
A4R38_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS06875	COG0667	Aldo Keto reductase
A4R38_RS06895	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A4R38_RS06900	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS06905	COG5557	Pfam Polysulphide reductase, NrfD
A4R38_RS06910	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A4R38_RS06915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4R38_RS06920	COG1773	rubredoxin
A4R38_RS06930	COG0298	carbon dioxide binding
A4R38_RS06935	COG0625	glutathione transferase activity
A4R38_RS06940	COG0754	glutathionylspermidine amidase activity
A4R38_RS06945	COG0306	phosphate transporter
A4R38_RS06950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R38_RS06955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R38_RS06960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R38_RS06965	COG2244	polysaccharide biosynthetic process
A4R38_RS06975	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4R38_RS06980	COG0795	lipopolysaccharide-transporting ATPase activity
A4R38_RS06990	COG0156	8-amino-7-oxononanoate synthase activity
A4R38_RS06995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R38_RS07005	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS07010	COG0456	acetyltransferase
A4R38_RS07015	COG2186	Transcriptional regulator
A4R38_RS07020	COG0277	FAD linked oxidase domain protein
A4R38_RS07025	COG0277	FAD linked oxidase domain protein
A4R38_RS07030	COG0247	lactate metabolic process
A4R38_RS07035	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A4R38_RS07040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4R38_RS07045	COG1620	l-lactate permease
A4R38_RS07055	COG3064	Membrane
A4R38_RS07060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4R38_RS07080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4R38_RS07085	COG1459	type II secretion system
A4R38_RS07090	COG2165	general secretion pathway protein
A4R38_RS07120	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A4R38_RS07180	COG1484	DNA-dependent DNA replication
A4R38_RS07185	COG4584	PFAM Integrase catalytic
A4R38_RS07240	COG2003	Belongs to the UPF0758 family
A4R38_RS07265	COG2020	methyltransferase activity
A4R38_RS07270	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS07280	COG4983	Phage plasmid primase, P4 family domain protein
A4R38_RS07320	COG4372	Transposase
A4R38_RS07325	COG4372	Transposase
A4R38_RS07330	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS07350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS07355	COG1940	carbohydrate kinase activity
A4R38_RS07360	COG2814	Major facilitator Superfamily
A4R38_RS07370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4R38_RS07375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A4R38_RS07380	COG0657	acetylesterase activity
A4R38_RS07380	COG2755	lipolytic protein G-D-S-L family
A4R38_RS07415	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS07420	COG4372	Transposase
A4R38_RS07430	COG4771	TonB-dependent receptor
A4R38_RS07495	COG2826	transposase and inactivated derivatives, IS30 family
A4R38_RS07505	COG2801	Transposase and inactivated derivatives
A4R38_RS07510	COG3344	reverse transcriptase
A4R38_RS07520	COG2826	transposase and inactivated derivatives, IS30 family
A4R38_RS07530	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS07620	COG3344	reverse transcriptase
A4R38_RS07675	COG0582	viral genome integration into host DNA
A4R38_RS07685	COG1811	Na channel or pump
A4R38_RS07690	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS07695	COG2211	Major facilitator Superfamily
A4R38_RS07710	COG1194	a g-specific adenine glycosylase
A4R38_RS07720	COG3171	Protein conserved in bacteria
A4R38_RS07735	COG0252	asparaginase activity
A4R38_RS07745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4R38_RS07760	COG0762	integral membrane protein
A4R38_RS07765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4R38_RS07770	COG2805	Type II/IV secretion system protein
A4R38_RS07785	COG0189	ligase activity
A4R38_RS07790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4R38_RS07795	COG2356	endonuclease I
A4R38_RS07805	COG2814	Major facilitator Superfamily
A4R38_RS07830	COG1166	arginine decarboxylase activity
A4R38_RS07845	COG0501	Belongs to the peptidase M48B family
A4R38_RS07850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4R38_RS07855	COG0330	HflC and HflK could
A4R38_RS07860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS07865	COG2213	PTS system mannitol-specific
A4R38_RS07870	COG1063	alcohol dehydrogenase
A4R38_RS07875	COG1494	fructose-1,6-bisphosphatase
A4R38_RS07885	COG1072	(Pantothenic acid kinase))
A4R38_RS07890	COG1122	ATPase activity
A4R38_RS07925	COG0191	fructose-bisphosphate aldolase activity
A4R38_RS07930	COG0668	transmembrane transport
A4R38_RS07935	COG1279	arginine transmembrane transporter activity
A4R38_RS07940	COG2968	Membrane
A4R38_RS07950	COG0583	DNA-binding transcription factor activity
A4R38_RS07955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R38_RS07955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R38_RS07975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R38_RS07980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4R38_RS08000	COG0006	proline dipeptidase activity
A4R38_RS08005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R38_RS08010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R38_RS08030	COG2723	6-phospho-beta-galactosidase activity
A4R38_RS08040	COG1272	protein, Hemolysin III
A4R38_RS08050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4R38_RS08060	COG0716	FMN binding
A4R38_RS08065	COG4974	Belongs to the 'phage' integrase family
A4R38_RS08070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R38_RS08075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4R38_RS08085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4R38_RS08100	COG2233	PERMEase
A4R38_RS08110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS08110	COG0493	'glutamate synthase
A4R38_RS08115	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS08120	COG2252	PERMEase
A4R38_RS08125	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS08130	COG2233	PERMEase
A4R38_RS08135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R38_RS08135	COG2080	2 iron, 2 sulfur cluster binding
A4R38_RS08140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R38_RS08145	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS08150	COG0493	'glutamate synthase
A4R38_RS08150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS08155	COG2068	MobA-Related Protein
A4R38_RS08160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4R38_RS08165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4R38_RS08165	COG3608	succinylglutamate desuccinylase aspartoacylase
A4R38_RS08170	COG0549	Belongs to the carbamate kinase family
A4R38_RS08180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R38_RS08185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R38_RS08190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4R38_RS08195	COG3829	transcription factor binding
A4R38_RS08200	COG2080	2 iron, 2 sulfur cluster binding
A4R38_RS08205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R38_RS08210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R38_RS08215	COG4942	peptidase
A4R38_RS08225	COG0814	amino acid
A4R38_RS08230	COG0183	Belongs to the thiolase family
A4R38_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS08245	COG2814	Major facilitator Superfamily
A4R38_RS08250	COG1794	racemase activity, acting on amino acids and derivatives
A4R38_RS08255	COG0583	DNA-binding transcription factor activity
A4R38_RS08265	COG1609	Transcriptional regulator
A4R38_RS08280	COG0667	Aldo Keto reductase
A4R38_RS08290	COG0861	Integral membrane protein TerC family
A4R38_RS08315	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A4R38_RS08330	COG2165	general secretion pathway protein
A4R38_RS08335	COG4795	General secretion pathway protein
A4R38_RS08345	COG4967	type IV pilus modification protein PilV
A4R38_RS08350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4R38_RS08355	COG1025	Belongs to the peptidase M16 family
A4R38_RS08360	COG1074	ATP-dependent DNA helicase activity
A4R38_RS08365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4R38_RS08370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4R38_RS08370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4R38_RS08375	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS08380	COG3711	transcriptional antiterminator
A4R38_RS08385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS08385	COG1263	PTS System
A4R38_RS08390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4R38_RS08405	COG4584	PFAM Integrase catalytic
A4R38_RS08410	COG1484	DNA-dependent DNA replication
A4R38_RS08525	COG2885	chlorophyll binding
A4R38_RS08565	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4R38_RS08570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4R38_RS08575	COG2166	iron-sulfur cluster assembly
A4R38_RS08580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R38_RS08590	COG0583	DNA-binding transcription factor activity
A4R38_RS08595	COG2363	Small membrane protein
A4R38_RS08605	COG1349	DNA-binding transcription factor activity
A4R38_RS08615	COG1070	Carbohydrate kinase
A4R38_RS08625	COG0738	Major facilitator superfamily
A4R38_RS08630	COG0235	Class ii aldolase
A4R38_RS08635	COG1454	alcohol dehydrogenase
A4R38_RS08645	COG1760	l-serine dehydratase
A4R38_RS08650	COG0814	amino acid
A4R38_RS08655	COG1611	Belongs to the LOG family
A4R38_RS08675	COG3098	single-species biofilm formation
A4R38_RS08680	COG0564	pseudouridine synthase activity
A4R38_RS08685	COG0716	FMN binding
A4R38_RS08690	COG2271	Major facilitator Superfamily
A4R38_RS08695	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS08700	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS08705	COG4999	Histidine kinase
A4R38_RS08705	COG3850	Histidine kinase
A4R38_RS08705	COG3437	response regulator, receiver
A4R38_RS08705	COG2205	protein histidine kinase activity
A4R38_RS08715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R38_RS08720	COG3956	TIGRFAM MazG family protein
A4R38_RS08735	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4R38_RS08745	COG0602	queuosine metabolic process
A4R38_RS08775	COG1070	Carbohydrate kinase
A4R38_RS08780	COG2223	nitrite transmembrane transporter activity
A4R38_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS08790	COG0277	FAD linked oxidase domain protein
A4R38_RS08795	COG0477	Major facilitator Superfamily
A4R38_RS08800	COG2086	electron transfer activity
A4R38_RS08805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4R38_RS08810	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A4R38_RS08815	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4R38_RS08820	COG0644	oxidoreductase
A4R38_RS08825	COG0720	synthase
A4R38_RS08850	COG2234	aminopeptidase activity
A4R38_RS08890	COG0585	pseudouridine synthase activity
A4R38_RS08905	COG1388	LysM domain
A4R38_RS08905	COG4942	peptidase
A4R38_RS08910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4R38_RS08925	COG2610	gluconate transmembrane transporter activity
A4R38_RS08930	COG3622	Belongs to the hyi family
A4R38_RS08935	COG0235	Class ii aldolase
A4R38_RS08940	COG3395	kinase activity
A4R38_RS08945	COG2084	Dehydrogenase
A4R38_RS08950	COG1349	DNA-binding transcription factor activity
A4R38_RS08955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R38_RS08960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4R38_RS08975	COG3604	Transcriptional regulator
A4R38_RS08980	COG0309	Hydrogenase expression formation protein (HypE)
A4R38_RS08985	COG0409	Hydrogenase expression formation protein
A4R38_RS08990	COG0298	carbon dioxide binding
A4R38_RS08995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4R38_RS09000	COG0375	protein maturation
A4R38_RS09015	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS09020	COG0651	ATP synthesis coupled electron transport
A4R38_RS09025	COG0650	Formate hydrogenlyase subunit 4
A4R38_RS09030	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A4R38_RS09030	COG3261	NADH dehydrogenase
A4R38_RS09035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R38_RS09040	COG3260	NADH ubiquinone oxidoreductase 20
A4R38_RS09050	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4R38_RS09055	COG5499	transcription regulator containing HTH domain
A4R38_RS09065	COG2723	6-phospho-beta-galactosidase activity
A4R38_RS09070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS09075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4R38_RS09095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4R38_RS09095	COG0517	IMP dehydrogenase activity
A4R38_RS09100	COG1349	DNA-binding transcription factor activity
A4R38_RS09105	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS09120	COG3732	PTS system glucitol sorbitol-specific
A4R38_RS09125	COG3730	PTS system glucitol sorbitol-specific
A4R38_RS09130	COG2951	lytic endotransglycosylase activity
A4R38_RS09140	COG1546	Belongs to the CinA family
A4R38_RS09165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4R38_RS09195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS09200	COG1238	metal cluster binding
A4R38_RS09225	COG2814	Major facilitator Superfamily
A4R38_RS09230	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS09235	COG1846	Transcriptional regulator
A4R38_RS09245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4R38_RS09250	COG2814	Major facilitator Superfamily
A4R38_RS09255	COG2113	Glycine betaine
A4R38_RS09260	COG4176	ABC-type proline glycine betaine transport system permease component
A4R38_RS09265	COG4175	Glycine betaine
A4R38_RS09270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS09275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS09285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4R38_RS09290	COG4575	ribosome binding
A4R38_RS09305	COG2916	Histone family protein nucleoid-structuring protein H-NS
A4R38_RS09310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4R38_RS09315	COG0640	Transcriptional regulator
A4R38_RS09320	COG0401	homolog of Blt101
A4R38_RS09325	COG1652	LysM domain
A4R38_RS09330	COG1802	Transcriptional regulator
A4R38_RS09335	COG1113	amino acid transport
A4R38_RS09340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4R38_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS09350	COG0579	oxidoreductase
A4R38_RS09370	COG2867	negative regulation of translational initiation
A4R38_RS09380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS09385	COG0497	DNA recombination
A4R38_RS09400	COG4536	flavin adenine dinucleotide binding
A4R38_RS09405	COG4137	Cytochrome C assembly protein
A4R38_RS09410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4R38_RS09435	COG2885	chlorophyll binding
A4R38_RS09440	COG2199	diguanylate cyclase activity
A4R38_RS09455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R38_RS09460	COG1605	Chorismate mutase
A4R38_RS09460	COG0287	Prephenate dehydrogenase
A4R38_RS09465	COG0077	Prephenate dehydratase
A4R38_RS09465	COG1605	Chorismate mutase
A4R38_RS09470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4R38_RS09480	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS09485	COG0564	pseudouridine synthase activity
A4R38_RS09495	COG0542	response to heat
A4R38_RS09520	COG0477	Major facilitator Superfamily
A4R38_RS09525	COG5544	Lipoprotein
A4R38_RS09530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS09535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS09535	COG1042	CoA-binding domain protein
A4R38_RS09535	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R38_RS09540	COG3148	PFAM DTW domain containing protein
A4R38_RS09545	COG3118	belongs to the thioredoxin family
A4R38_RS09555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R38_RS09575	COG0583	DNA-binding transcription factor activity
A4R38_RS09580	COG0513	Belongs to the DEAD box helicase family
A4R38_RS09590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4R38_RS09600	COG1595	DNA-templated transcription, initiation
A4R38_RS09605	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A4R38_RS09610	COG3026	antisigma factor binding
A4R38_RS09615	COG3086	response to oxidative stress
A4R38_RS09625	COG0681	Belongs to the peptidase S26 family
A4R38_RS09645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4R38_RS09665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS09670	COG1737	Transcriptional regulator
A4R38_RS09675	COG0560	Phosphoserine phosphatase
A4R38_RS09680	COG0590	tRNA wobble adenosine to inosine editing
A4R38_RS09695	COG2205	protein histidine kinase activity
A4R38_RS09700	COG3170	Tfp pilus assembly protein FimV
A4R38_RS09705	COG2204	response regulator
A4R38_RS09710	COG0347	Belongs to the P(II) protein family
A4R38_RS09715	COG1017	nitric oxide dioxygenase activity
A4R38_RS09715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R38_RS09725	COG1940	carbohydrate kinase activity
A4R38_RS09730	COG0457	Tetratricopeptide repeat
A4R38_RS09735	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS09740	COG1129	ABC transporter
A4R38_RS09745	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS09750	COG1063	alcohol dehydrogenase
A4R38_RS09755	COG2017	converts alpha-aldose to the beta-anomer
A4R38_RS09760	COG2259	Doxx family
A4R38_RS09765	COG2814	Major facilitator Superfamily
A4R38_RS09770	COG3711	transcriptional antiterminator
A4R38_RS09775	COG1073	alpha beta
A4R38_RS09780	COG0483	inositol monophosphate 1-phosphatase activity
A4R38_RS09800	COG0822	iron-sulfur transferase activity
A4R38_RS09820	COG0633	Ferredoxin
A4R38_RS09825	COG2975	iron-sulfur cluster assembly
A4R38_RS09840	COG2897	thiosulfate sulfurtransferase activity
A4R38_RS09845	COG2373	Large extracellular alpha-helical protein
A4R38_RS09850	COG4953	penicillin-binding protein 1C
A4R38_RS09880	COG2976	Protein conserved in bacteria
A4R38_RS09895	COG1645	bacterial-type flagellum-dependent swarming motility
A4R38_RS09920	COG0517	IMP dehydrogenase activity
A4R38_RS09920	COG0516	GMP reductase activity
A4R38_RS09935	COG3133	Outer membrane lipoprotein
A4R38_RS09950	COG2200	EAL domain
A4R38_RS09955	COG0248	Ppx GppA phosphatase
A4R38_RS09960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4R38_RS09965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4R38_RS09980	COG2233	PERMEase
A4R38_RS09990	COG1393	Belongs to the ArsC family
A4R38_RS09995	COG4783	chaperone-mediated protein folding
A4R38_RS10000	COG0628	permease
A4R38_RS10005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4R38_RS10010	COG2716	regulation of RNA biosynthetic process
A4R38_RS10020	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A4R38_RS10035	COG2321	neutral zinc metallopeptidase
A4R38_RS10045	COG0400	carboxylic ester hydrolase activity
A4R38_RS10060	COG1393	Belongs to the ArsC family
A4R38_RS10070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS10075	COG3850	Histidine kinase
A4R38_RS10080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS10080	COG0493	'glutamate synthase
A4R38_RS10090	COG5342	invasion associated locus B
A4R38_RS10095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4R38_RS10100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R38_RS10105	COG0281	malic enzyme
A4R38_RS10105	COG0280	phosphate acetyltransferase
A4R38_RS10110	COG4810	utilization protein
A4R38_RS10115	COG4917	ethanolamine utilization protein
A4R38_RS10120	COG4766	ethanolamine catabolic process
A4R38_RS10125	COG4812	Cobalamin adenosyltransferase
A4R38_RS10130	COG0280	phosphate acetyltransferase
A4R38_RS10135	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4R38_RS10140	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A4R38_RS10145	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS10150	COG4820	ethanolamine utilization protein (EutJ)
A4R38_RS10155	COG1454	alcohol dehydrogenase
A4R38_RS10160	COG3192	ethanolamine utilization protein
A4R38_RS10165	COG4819	ethanolamine utilization protein
A4R38_RS10170	COG4303	Ethanolamine ammonia lyase large subunit
A4R38_RS10180	COG4816	utilization protein
A4R38_RS10185	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4R38_RS10190	COG2207	Transcriptional regulator
A4R38_RS10200	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS10220	COG2837	iron assimilation
A4R38_RS10225	COG1263	PTS System
A4R38_RS10225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS10235	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS10240	COG4150	thiosulfate binding
A4R38_RS10245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4R38_RS10250	COG4208	sulfate ABC transporter
A4R38_RS10255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4R38_RS10260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R38_RS10275	COG2190	(PTS) system
A4R38_RS10280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS10285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS10290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R38_RS10310	COG3530	Putative quorum-sensing-regulated virulence factor
A4R38_RS10315	COG0385	Bile acid
A4R38_RS10320	COG0583	DNA-binding transcription factor activity
A4R38_RS10330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4R38_RS10335	COG2211	Major facilitator Superfamily
A4R38_RS10345	COG0583	DNA-binding transcription factor activity
A4R38_RS10370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4R38_RS10375	COG3415	Transposase
A4R38_RS10380	COG3415	Transposase
A4R38_RS10395	COG2199	diguanylate cyclase activity
A4R38_RS10395	COG2200	EAL domain
A4R38_RS10400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4R38_RS10430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS10435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS10440	COG0006	proline dipeptidase activity
A4R38_RS10445	COG1363	Peptidase, m42
A4R38_RS10450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS10450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS10450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS10455	COG2207	Transcriptional regulator
A4R38_RS10460	COG3279	Response regulator of the LytR AlgR family
A4R38_RS10465	COG3275	phosphorelay sensor kinase activity
A4R38_RS10470	COG0436	Aminotransferase
A4R38_RS10475	COG1560	Kdo2-lipid A biosynthetic process
A4R38_RS10505	COG0028	Belongs to the TPP enzyme family
A4R38_RS10510	COG0679	Auxin Efflux Carrier
A4R38_RS10515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R38_RS10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS10520	COG2198	Histidine kinase
A4R38_RS10520	COG2205	protein histidine kinase activity
A4R38_RS10520	COG0784	Response regulator, receiver
A4R38_RS10525	COG2197	response regulator
A4R38_RS10530	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS10535	COG0477	Major facilitator Superfamily
A4R38_RS10545	COG2610	gluconate transmembrane transporter activity
A4R38_RS10550	COG0583	DNA-binding transcription factor activity
A4R38_RS10560	COG2116	formate transmembrane transporter activity
A4R38_RS10570	COG2067	long-chain fatty acid transport protein
A4R38_RS10575	COG3691	Protein conserved in bacteria
A4R38_RS10590	COG2062	phosphohistidine phosphatase, SixA
A4R38_RS10595	COG3539	Fimbrial protein
A4R38_RS10600	COG3188	usher protein
A4R38_RS10605	COG1662	PFAM IS1 transposase
A4R38_RS10610	COG3188	usher protein
A4R38_RS10615	COG3121	Chaperone
A4R38_RS10620	COG3539	Fimbrial protein
A4R38_RS10625	COG3539	Fimbrial protein
A4R38_RS10630	COG3539	Fimbrial protein
A4R38_RS10660	COG0730	response to heat
A4R38_RS10665	COG3101	peptidyl-lysine hydroxylation
A4R38_RS10680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4R38_RS10685	COG2814	Major facilitator Superfamily
A4R38_RS10700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4R38_RS10710	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS10720	COG0285	dihydrofolate synthase activity
A4R38_RS10725	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A4R38_RS10730	COG1286	toxin biosynthetic process
A4R38_RS10735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4R38_RS10740	COG0163	prenyltransferase activity
A4R38_RS10745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS10750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS10755	COG4215	(ABC) transporter
A4R38_RS10760	COG4160	amino acid transport
A4R38_RS10765	COG4598	ABC transporter
A4R38_RS10770	COG1090	epimerase
A4R38_RS10775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4R38_RS10780	COG0625	glutathione transferase activity
A4R38_RS10785	COG0625	glutathione transferase activity
A4R38_RS10790	COG0622	Phosphoesterase
A4R38_RS10795	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4R38_RS10800	COG1288	antiporter activity
A4R38_RS10805	COG0280	phosphate acetyltransferase
A4R38_RS10805	COG0857	belongs to the CobB CobQ family
A4R38_RS10810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4R38_RS10830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS10835	COG0471	metal ion transport
A4R38_RS10835	COG0490	domain, Protein
A4R38_RS10845	COG0436	Aminotransferase
A4R38_RS10850	COG0583	DNA-binding transcription factor activity
A4R38_RS10870	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A4R38_RS10875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4R38_RS10880	COG1034	ATP synthesis coupled electron transport
A4R38_RS10895	COG0839	Belongs to the complex I subunit 6 family
A4R38_RS10905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4R38_RS10910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R38_RS10925	COG2234	aminopeptidase activity
A4R38_RS10930	COG2304	oxidoreductase activity
A4R38_RS10940	COG2153	protein acetylation
A4R38_RS10945	COG4575	ribosome binding
A4R38_RS10950	COG1169	isochorismate synthase
A4R38_RS10965	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4R38_RS10975	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS10995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R38_RS11040	COG1414	Transcriptional regulator
A4R38_RS11045	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS11050	COG2271	Major facilitator Superfamily
A4R38_RS11055	COG3836	Belongs to the HpcH HpaI aldolase family
A4R38_RS11065	COG5464	transposase or invertase
A4R38_RS11070	COG0247	lactate metabolic process
A4R38_RS11080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4R38_RS11085	COG2271	Major facilitator Superfamily
A4R38_RS11090	COG0584	glycerophosphoryl diester phosphodiesterase
A4R38_RS11095	COG3642	lipopolysaccharide core region biosynthetic process
A4R38_RS11100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R38_RS11105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS11110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS11120	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS11130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4R38_RS11135	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
A4R38_RS11140	COG3234	Protein of unknown function (DUF1175)
A4R38_RS11145	COG2373	Large extracellular alpha-helical protein
A4R38_RS11150	COG5445	Predicted secreted protein (DUF2300)
A4R38_RS11160	COG4382	Mu-like prophage protein Gp16
A4R38_RS11190	COG4396	Host-nuclease inhibitor protein Gam
A4R38_RS11200	COG3267	Type II secretory pathway component ExeA
A4R38_RS11200	COG3409	Peptidoglycan-binding domain 1 protein
A4R38_RS11285	COG4373	Mu-like prophage FluMu protein gp28
A4R38_RS11295	COG2369	cell adhesion
A4R38_RS11410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4R38_RS11415	COG5445	Predicted secreted protein (DUF2300)
A4R38_RS11420	COG4676	Protein conserved in bacteria
A4R38_RS11425	COG0183	Belongs to the thiolase family
A4R38_RS11430	COG2031	fatty acid transporter
A4R38_RS11435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4R38_RS11440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4R38_RS11445	COG2204	response regulator
A4R38_RS11450	COG3852	Histidine kinase
A4R38_RS11455	COG0784	Response regulator, receiver
A4R38_RS11455	COG2205	protein histidine kinase activity
A4R38_RS11460	COG2197	response regulator
A4R38_RS11465	COG0642	Histidine kinase
A4R38_RS11465	COG2198	Histidine kinase
A4R38_RS11485	COG1477	protein flavinylation
A4R38_RS11490	COG2169	Transcriptional regulator
A4R38_RS11490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R38_RS11495	COG3145	DNA-N1-methyladenine dioxygenase activity
A4R38_RS11500	COG4615	Cyclic peptide transporter
A4R38_RS11520	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS11520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS11525	COG3062	negative regulation of establishment of protein localization
A4R38_RS11535	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS11540	COG0348	domain, Protein
A4R38_RS11545	COG3043	anaerobic respiration
A4R38_RS11550	COG3005	denitrification pathway
A4R38_RS11555	COG4133	protoheme IX ABC transporter activity
A4R38_RS11560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R38_RS11565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R38_RS11570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R38_RS11580	COG1138	Cytochrome C-type biogenesis protein
A4R38_RS11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R38_RS11590	COG3088	subunit of a heme lyase
A4R38_RS11590	COG4235	cytochrome complex assembly
A4R38_RS11595	COG2197	response regulator
A4R38_RS11605	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS11610	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS11620	COG3083	sulfuric ester hydrolase activity
A4R38_RS11640	COG1061	Type III restriction enzyme res subunit
A4R38_RS11645	COG1187	pseudouridine synthase activity
A4R38_RS11650	COG2814	Major facilitator Superfamily
A4R38_RS11660	COG4172	Belongs to the ABC transporter superfamily
A4R38_RS11665	COG4239	(ABC) transporter, permease
A4R38_RS11670	COG4174	ABC transporter (Permease)
A4R38_RS11675	COG4166	transmembrane transport
A4R38_RS11680	COG2200	EAL domain
A4R38_RS11685	COG0791	NLP P60 protein
A4R38_RS11690	COG0671	phosphoesterase, PA-phosphatase related
A4R38_RS11695	COG0523	cobalamin synthesis protein
A4R38_RS11700	COG0246	Mannitol dehydrogenase
A4R38_RS11715	COG2814	Major facilitator Superfamily
A4R38_RS11720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS11720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS11725	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R38_RS11730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS11730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS11730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4R38_RS11735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS11740	COG2313	pseudouridylate synthase activity
A4R38_RS11745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4R38_RS11750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS11760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS11760	COG1522	sequence-specific DNA binding
A4R38_RS11770	COG2855	membrane
A4R38_RS11775	COG0583	DNA-binding transcription factor activity
A4R38_RS11780	COG0833	amino acid
A4R38_RS11790	COG4771	TonB-dependent receptor
A4R38_RS11810	COG2311	Membrane
A4R38_RS11820	COG1609	Transcriptional regulator
A4R38_RS11825	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS11835	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS11840	COG0167	dihydroorotate dehydrogenase activity
A4R38_RS11840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4R38_RS11845	COG0493	'glutamate synthase
A4R38_RS11855	COG2949	membrane
A4R38_RS11865	COG1346	cytolysis
A4R38_RS11875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4R38_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS11895	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS11905	COG1686	Belongs to the peptidase S11 family
A4R38_RS11910	COG0277	FAD linked oxidase domain protein
A4R38_RS11915	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R38_RS11920	COG1732	Glycine betaine
A4R38_RS11925	COG1174	glycine betaine transport
A4R38_RS11930	COG1125	glycine betaine transport
A4R38_RS11935	COG1174	glycine betaine transport
A4R38_RS11945	COG0789	Transcriptional regulator
A4R38_RS11950	COG3275	phosphorelay sensor kinase activity
A4R38_RS11955	COG3279	Response regulator of the LytR AlgR family
A4R38_RS11960	COG4807	Protein conserved in bacteria
A4R38_RS11965	COG4808	Protein conserved in bacteria
A4R38_RS11980	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4R38_RS11985	COG0714	Associated with various cellular activities
A4R38_RS12000	COG3831	ATPase activity
A4R38_RS12005	COG3831	ATPase activity
A4R38_RS12010	COG3831	ATPase activity
A4R38_RS12020	COG0489	protein tyrosine kinase activity
A4R38_RS12035	COG3539	Fimbrial protein
A4R38_RS12040	COG3121	Chaperone
A4R38_RS12045	COG3188	usher protein
A4R38_RS12050	COG3539	Fimbrial protein
A4R38_RS12055	COG5455	response to cobalt ion
A4R38_RS12075	COG0351	phosphomethylpyrimidine kinase
A4R38_RS12080	COG3757	hydrolase, family 25
A4R38_RS12085	COG2188	Transcriptional regulator
A4R38_RS12090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS12095	COG1397	ADP-ribosylglycohydrolase
A4R38_RS12100	COG2211	Major facilitator Superfamily
A4R38_RS12105	COG1830	Aldolase
A4R38_RS12120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS12125	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS12130	COG3775	system Galactitol-specific IIC component
A4R38_RS12135	COG1063	alcohol dehydrogenase
A4R38_RS12155	COG0826	peptidase U32
A4R38_RS12165	COG0745	RESPONSE REGULATOR receiver
A4R38_RS12170	COG2205	protein histidine kinase activity
A4R38_RS12195	COG4245	von Willebrand factor, type A
A4R38_RS12200	COG0631	protein serine/threonine phosphatase activity
A4R38_RS12205	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
A4R38_RS12210	COG0443	Heat shock 70 kDa protein
A4R38_RS12215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A4R38_RS12220	COG3447	MASE1 domain protein
A4R38_RS12220	COG5001	Diguanylate cyclase
A4R38_RS12220	COG5002	protein histidine kinase activity
A4R38_RS12225	COG0572	uridine kinase
A4R38_RS12235	COG2982	Protein involved in outer membrane biogenesis
A4R38_RS12240	COG1253	flavin adenine dinucleotide binding
A4R38_RS12245	COG1596	polysaccharide export
A4R38_RS12250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4R38_RS12255	COG0489	protein tyrosine kinase activity
A4R38_RS12255	COG3206	protein involved in exopolysaccharide biosynthesis
A4R38_RS12260	COG0463	Glycosyl transferase, family 2
A4R38_RS12265	COG1045	serine acetyltransferase
A4R38_RS12270	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS12280	COG1216	Glycosyl transferase, family 2
A4R38_RS12285	COG0110	maltose O-acetyltransferase activity
A4R38_RS12290	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4R38_RS12295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS12300	COG1051	belongs to the nudix hydrolase family
A4R38_RS12305	COG0297	glycogen (starch) synthase activity
A4R38_RS12310	COG0662	Cupin 2, conserved barrel domain protein
A4R38_RS12310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A4R38_RS12315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4R38_RS12320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4R38_RS12325	COG2244	polysaccharide biosynthetic process
A4R38_RS12330	COG2327	Polysaccharide pyruvyl transferase
A4R38_RS12335	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS12345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS12350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4R38_RS12355	COG1216	Glycosyl transferase, family 2
A4R38_RS12365	COG0463	Glycosyl transferase, family 2
A4R38_RS12395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4R38_RS12400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4R38_RS12405	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4R38_RS12410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4R38_RS12410	COG0140	phosphoribosyl-ATP diphosphatase activity
A4R38_RS12425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4R38_RS12430	COG0131	Imidazoleglycerol-phosphate dehydratase
A4R38_RS12430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4R38_RS12440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4R38_RS12450	COG2161	toxin-antitoxin pair type II binding
A4R38_RS12455	COG4115	mRNA cleavage
A4R38_RS12460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS12465	COG0583	DNA-binding transcription factor activity
A4R38_RS12470	COG0531	amino acid
A4R38_RS12475	COG2925	Exonuclease
A4R38_RS12480	COG1686	Belongs to the peptidase S11 family
A4R38_RS12490	COG1289	transmembrane transporter activity
A4R38_RS12505	COG4372	Transposase
A4R38_RS12510	COG4584	PFAM Integrase catalytic
A4R38_RS12515	COG1484	DNA-dependent DNA replication
A4R38_RS12545	COG2003	Belongs to the UPF0758 family
A4R38_RS12600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS12605	COG1120	ATPase activity
A4R38_RS12660	COG3547	Transposase (IS116 IS110 IS902 family)
A4R38_RS12670	COG4372	Transposase
A4R38_RS12675	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS12725	COG0405	Gamma-glutamyltransferase
A4R38_RS12730	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A4R38_RS12745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS12765	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS12770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R38_RS12775	COG3969	phosphoadenosine phosphosulfate
A4R38_RS12780	COG1475	DNA binding
A4R38_RS12785	COG4771	TonB-dependent receptor
A4R38_RS12795	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
A4R38_RS12810	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS12820	COG0583	DNA-binding transcription factor activity
A4R38_RS12825	COG0583	DNA-binding transcription factor activity
A4R38_RS12835	COG0534	Mate efflux family protein
A4R38_RS12845	COG0217	transcriptional regulatory protein
A4R38_RS12850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4R38_RS12855	COG0477	Major facilitator Superfamily
A4R38_RS12865	COG1662	PFAM IS1 transposase
A4R38_RS12870	COG1388	LysM domain
A4R38_RS12870	COG1470	cell adhesion involved in biofilm formation
A4R38_RS12875	COG1388	LysM domain
A4R38_RS12875	COG1470	cell adhesion involved in biofilm formation
A4R38_RS12880	COG1470	cell adhesion involved in biofilm formation
A4R38_RS12880	COG1388	LysM domain
A4R38_RS12885	COG1388	LysM domain
A4R38_RS12885	COG2373	Large extracellular alpha-helical protein
A4R38_RS12885	COG4932	domain protein
A4R38_RS12890	COG4771	TonB-dependent receptor
A4R38_RS12895	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4R38_RS12915	COG2226	methyltransferase
A4R38_RS12915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R38_RS12915	COG3433	isochorismatase activity
A4R38_RS12930	COG1132	(ABC) transporter
A4R38_RS12935	COG2814	Major facilitator Superfamily
A4R38_RS12940	COG1169	isochorismate synthase
A4R38_RS12945	COG1662	PFAM IS1 transposase
A4R38_RS12950	COG0582	viral genome integration into host DNA
A4R38_RS12975	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4R38_RS12990	COG2351	hydroxyisourate hydrolase activity
A4R38_RS12995	COG0745	RESPONSE REGULATOR receiver
A4R38_RS13000	COG2205	protein histidine kinase activity
A4R38_RS13015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4R38_RS13025	COG1418	mRNA catabolic process
A4R38_RS13030	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4R38_RS13035	COG3727	T/G mismatch-specific endonuclease activity
A4R38_RS13040	COG0697	spore germination
A4R38_RS13045	COG2354	Protein conserved in bacteria
A4R38_RS13050	COG5475	Uncharacterized small protein (DUF2158)
A4R38_RS13055	COG3706	GGDEF domain
A4R38_RS13075	COG2197	response regulator
A4R38_RS13080	COG1684	flagellar biosynthetic protein fliR
A4R38_RS13085	COG1987	bacterial-type flagellum assembly
A4R38_RS13090	COG1338	Plays a role in the flagellum-specific transport system
A4R38_RS13095	COG3190	flagellar
A4R38_RS13100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4R38_RS13105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4R38_RS13110	COG1580	Controls the rotational direction of flagella during chemotaxis
A4R38_RS13115	COG3144	bacterial-type flagellum assembly
A4R38_RS13120	COG2882	bacterial-type flagellum organization
A4R38_RS13125	COG1157	protein secretion by the type III secretion system
A4R38_RS13130	COG1317	bacterial-type flagellum organization
A4R38_RS13135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4R38_RS13140	COG1766	The M ring may be actively involved in energy transduction
A4R38_RS13155	COG2076	Multidrug Resistance protein
A4R38_RS13160	COG1881	PFAM PEBP family protein
A4R38_RS13165	COG2207	Transcriptional regulator
A4R38_RS13175	COG0675	Transposase, IS605 OrfB family
A4R38_RS13185	COG0425	Belongs to the sulfur carrier protein TusA family
A4R38_RS13190	COG2391	methyltransferase activity
A4R38_RS13200	COG0366	Alpha amylase catalytic
A4R38_RS13210	COG1516	flagellar protein fliS
A4R38_RS13215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A4R38_RS13225	COG1191	sigma factor activity
A4R38_RS13235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS13245	COG0765	amino acid transport
A4R38_RS13250	COG1126	abc transporter atp-binding protein
A4R38_RS13255	COG2197	response regulator
A4R38_RS13270	COG2197	response regulator
A4R38_RS13300	COG3012	SEC-C Motif Domain Protein
A4R38_RS13300	COG3318	Belongs to the UPF0149 family
A4R38_RS13305	COG0814	amino acid
A4R38_RS13315	COG1528	Iron-storage protein
A4R38_RS13335	COG1528	Iron-storage protein
A4R38_RS13340	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS13350	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS13355	COG1877	trehalose-phosphatase activity
A4R38_RS13365	COG0589	response to stress
A4R38_RS13380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A4R38_RS13385	COG1360	Flagellar Motor Protein
A4R38_RS13390	COG0643	Histidine kinase
A4R38_RS13390	COG2198	Histidine kinase
A4R38_RS13395	COG0835	chemotaxis
A4R38_RS13400	COG0840	transmembrane signaling receptor activity
A4R38_RS13405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A4R38_RS13415	COG0745	RESPONSE REGULATOR receiver
A4R38_RS13420	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A4R38_RS13425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4R38_RS13430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4R38_RS13445	COG3102	Protein conserved in bacteria
A4R38_RS13455	COG3005	denitrification pathway
A4R38_RS13460	COG0243	molybdopterin cofactor binding
A4R38_RS13475	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A4R38_RS13480	COG1801	Protein of unknown function DUF72
A4R38_RS13485	COG1335	isochorismatase
A4R38_RS13495	COG0494	nUDIX hydrolase
A4R38_RS13500	COG0217	transcriptional regulatory protein
A4R38_RS13530	COG2801	Transposase and inactivated derivatives
A4R38_RS13535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS13545	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4R38_RS13550	COG0739	heme binding
A4R38_RS13555	COG1560	Kdo2-lipid A biosynthetic process
A4R38_RS13560	COG0469	pyruvate kinase activity
A4R38_RS13565	COG1737	Transcriptional regulator
A4R38_RS13575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4R38_RS13580	COG0129	dihydroxy-acid dehydratase activity
A4R38_RS13585	COG0800	Aldolase
A4R38_RS13595	COG3141	response to X-ray
A4R38_RS13610	COG2979	Protein of unknown function (DUF533)
A4R38_RS13615	COG1770	oligopeptidase
A4R38_RS13620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS13625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R38_RS13635	COG2372	response to copper ion
A4R38_RS13640	COG1276	copper resistance
A4R38_RS13655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R38_RS13675	COG3008	intermembrane lipid transfer
A4R38_RS13680	COG2995	paraquat-inducible protein a
A4R38_RS13685	COG1956	GAF domain-containing protein
A4R38_RS13695	COG0793	Belongs to the peptidase S41A family
A4R38_RS13705	COG2814	Major facilitator Superfamily
A4R38_RS13710	COG1414	Transcriptional regulator
A4R38_RS13745	COG2226	methyltransferase
A4R38_RS13765	COG3716	PTS system mannose fructose sorbose family IID component
A4R38_RS13770	COG3715	PTS system
A4R38_RS13775	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS13775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS13785	COG1253	flavin adenine dinucleotide binding
A4R38_RS13790	COG2200	EAL domain
A4R38_RS13795	COG1760	l-serine dehydratase
A4R38_RS13805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4R38_RS13825	COG0251	oxidation-reduction process
A4R38_RS13830	COG1199	ATP-dependent helicase activity
A4R38_RS13835	COG1214	PFAM Peptidase M22, glycoprotease
A4R38_RS13840	COG3065	identical protein binding
A4R38_RS13845	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS13850	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4R38_RS13855	COG0473	3-isopropylmalate dehydrogenase activity
A4R38_RS13860	COG0583	DNA-binding transcription factor activity
A4R38_RS13870	COG3615	Tellurite resistance protein tehB
A4R38_RS13880	COG2261	transglycosylase associated protein
A4R38_RS13890	COG2199	diguanylate cyclase activity
A4R38_RS13890	COG2203	Gaf domain
A4R38_RS13895	COG3042	response to heat
A4R38_RS13900	COG3189	MarR family transcriptional regulator
A4R38_RS13905	COG2807	transmembrane transport
A4R38_RS13910	COG2207	Transcriptional regulator
A4R38_RS13925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4R38_RS13930	COG2199	diguanylate cyclase activity
A4R38_RS13935	COG2199	diguanylate cyclase activity
A4R38_RS13945	COG2766	serine protein kinase
A4R38_RS13950	COG3713	MltA-interacting MipA family protein
A4R38_RS13955	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS13960	COG0676	glucose-6-phosphate 1-epimerase activity
A4R38_RS13965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4R38_RS13975	COG3139	Protein of unknown function (DUF1315)
A4R38_RS13980	COG1063	alcohol dehydrogenase
A4R38_RS13985	COG2271	Major facilitator Superfamily
A4R38_RS13990	COG1063	alcohol dehydrogenase
A4R38_RS13995	COG0191	fructose-bisphosphate aldolase activity
A4R38_RS14000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS14005	COG0667	Aldo Keto reductase
A4R38_RS14010	COG1349	DNA-binding transcription factor activity
A4R38_RS14015	COG2814	Major facilitator Superfamily
A4R38_RS14020	COG1335	isochorismatase
A4R38_RS14025	COG0252	asparaginase activity
A4R38_RS14035	COG0616	signal peptide processing
A4R38_RS14045	COG0778	Nitroreductase
A4R38_RS14055	COG0709	Synthesizes selenophosphate from selenide and ATP
A4R38_RS14060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4R38_RS14065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4R38_RS14075	COG0494	nUDIX hydrolase
A4R38_RS14080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4R38_RS14085	COG2897	thiosulfate sulfurtransferase activity
A4R38_RS14090	COG4136	ATPase activity
A4R38_RS14095	COG4135	transport system, permease component
A4R38_RS14100	COG4134	Bacterial extracellular solute-binding protein
A4R38_RS14105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R38_RS14110	COG0398	Pfam SNARE associated Golgi protein
A4R38_RS14120	COG0398	Pfam SNARE associated Golgi protein
A4R38_RS14125	COG0708	Exodeoxyribonuclease III
A4R38_RS14155	COG3678	ATP-independent chaperone mediated protein folding
A4R38_RS14165	COG0322	excinuclease ABC activity
A4R38_RS14180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS14185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4R38_RS14190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4R38_RS14195	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4R38_RS14200	COG1917	Cupin 2, conserved barrel domain protein
A4R38_RS14200	COG2169	Transcriptional regulator
A4R38_RS14205	COG1486	melibiose metabolic process
A4R38_RS14210	COG3394	polysaccharide catabolic process
A4R38_RS14215	COG0753	catalase activity
A4R38_RS14225	COG1823	symporter activity
A4R38_RS14230	COG1988	membrane-bound metal-dependent
A4R38_RS14235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS14245	COG3001	Fructosamine kinase
A4R38_RS14255	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R38_RS14260	COG3137	Salt-induced outer membrane protein
A4R38_RS14320	COG0386	Belongs to the glutathione peroxidase family
A4R38_RS14330	COG0791	NLP P60 protein
A4R38_RS14335	COG2200	EAL domain
A4R38_RS14345	COG4256	Hemin uptake protein
A4R38_RS14350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R38_RS14365	COG0574	Belongs to the PEP-utilizing enzyme family
A4R38_RS14365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS14370	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS14375	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4R38_RS14380	COG0644	oxidoreductase
A4R38_RS14385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4R38_RS14390	COG2086	electron transfer activity
A4R38_RS14400	COG2207	Transcriptional regulator
A4R38_RS14400	COG1917	Cupin 2, conserved barrel domain protein
A4R38_RS14405	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS14410	COG4670	ketone body catabolic process
A4R38_RS14425	COG2271	Major facilitator Superfamily
A4R38_RS14430	COG0738	Major facilitator superfamily
A4R38_RS14445	COG0628	permease
A4R38_RS14450	COG0247	lactate metabolic process
A4R38_RS14450	COG0277	FAD linked oxidase domain protein
A4R38_RS14455	COG2050	protein possibly involved in aromatic compounds catabolism
A4R38_RS14465	COG0316	Belongs to the HesB IscA family
A4R38_RS14470	COG0719	Fe-S assembly protein
A4R38_RS14475	COG0396	ATPase activity
A4R38_RS14480	COG0719	Fe-S assembly protein
A4R38_RS14495	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS14500	COG4238	major outer membrane lipoprotein
A4R38_RS14505	COG0469	pyruvate kinase activity
A4R38_RS14515	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS14520	COG2414	aldehyde ferredoxin oxidoreductase
A4R38_RS14530	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS14535	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A4R38_RS14545	COG4529	Protein conserved in bacteria
A4R38_RS14565	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS14575	COG0307	riboflavin synthase, alpha
A4R38_RS14580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R38_RS14585	COG2814	Major facilitator Superfamily
A4R38_RS14590	COG0583	DNA-binding transcription factor activity
A4R38_RS14605	COG2814	Major facilitator Superfamily
A4R38_RS14610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4R38_RS14615	COG0791	NLP P60 protein
A4R38_RS14620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4R38_RS14625	COG1201	RNA secondary structure unwinding
A4R38_RS14635	COG0346	lactoylglutathione lyase activity
A4R38_RS14640	COG1902	pentaerythritol trinitrate reductase activity
A4R38_RS14645	COG1309	transcriptional regulator
A4R38_RS14650	COG3313	Fe-S protein
A4R38_RS14655	COG4989	oxidoreductase activity
A4R38_RS14660	COG2032	superoxide dismutase activity
A4R38_RS14665	COG1289	transmembrane transporter activity
A4R38_RS14670	COG1289	transmembrane transporter activity
A4R38_RS14675	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS14690	COG3133	Outer membrane lipoprotein
A4R38_RS14700	COG3895	Periplasmic Protein
A4R38_RS14720	COG0625	glutathione transferase activity
A4R38_RS14725	COG3104	oligopeptide transport
A4R38_RS14735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4R38_RS14745	COG4659	FMN binding
A4R38_RS14785	COG0673	inositol 2-dehydrogenase activity
A4R38_RS14795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4R38_RS14800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS14800	COG1263	PTS System
A4R38_RS14805	COG1609	Transcriptional regulator
A4R38_RS14810	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS14815	COG1309	transcriptional regulator
A4R38_RS14820	COG3250	beta-galactosidase activity
A4R38_RS14835	COG5339	Protein conserved in bacteria
A4R38_RS14840	COG1482	cell wall glycoprotein biosynthetic process
A4R38_RS14845	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS14845	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS14850	COG0114	fumarate hydratase activity
A4R38_RS14860	COG2205	protein histidine kinase activity
A4R38_RS14865	COG0745	RESPONSE REGULATOR receiver
A4R38_RS14870	COG3136	membrane protein required for alginate biosynthesis
A4R38_RS14875	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS14880	COG0531	amino acid
A4R38_RS14890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4R38_RS14895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4R38_RS14900	COG0628	permease
A4R38_RS14915	COG3591	Belongs to the peptidase S1B family
A4R38_RS14930	COG2814	Major facilitator Superfamily
A4R38_RS14935	COG0583	DNA-binding transcription factor activity
A4R38_RS14940	COG1940	carbohydrate kinase activity
A4R38_RS14945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R38_RS14955	COG3381	protein complex oligomerization
A4R38_RS14960	COG3302	dmso reductase anchor subunit
A4R38_RS14965	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS14975	COG0243	molybdopterin cofactor binding
A4R38_RS14990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS15005	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS15010	COG1063	alcohol dehydrogenase
A4R38_RS15015	COG0582	viral genome integration into host DNA
A4R38_RS15025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS15050	COG1396	sequence-specific DNA binding
A4R38_RS15065	COG1846	Transcriptional regulator
A4R38_RS15075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4R38_RS15090	COG2801	Transposase and inactivated derivatives
A4R38_RS15100	COG3077	Addiction module antitoxin, RelB DinJ family
A4R38_RS15105	COG2026	Addiction module toxin, RelE StbE family
A4R38_RS15125	COG1403	HNH endonuclease
A4R38_RS15130	COG0484	heat shock protein binding
A4R38_RS15135	COG1278	Cold shock
A4R38_RS15140	COG1278	Cold shock
A4R38_RS15155	COG3772	lysozyme
A4R38_RS15165	COG1278	Cold shock
A4R38_RS15180	COG5562	phage envelope protein
A4R38_RS15190	COG4220	transposase activity
A4R38_RS15210	COG1030	water channel activity
A4R38_RS15260	COG1196	nuclear chromosome segregation
A4R38_RS15295	COG5301	cellulose 1,4-beta-cellobiosidase activity
A4R38_RS15315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4R38_RS15325	COG0477	Major facilitator Superfamily
A4R38_RS15330	COG0246	Mannitol dehydrogenase
A4R38_RS15340	COG1802	Transcriptional regulator
A4R38_RS15345	COG4221	oxidoreductase activity
A4R38_RS15350	COG0339	signal peptide processing
A4R38_RS15355	COG3111	PFAM Bacterial OB fold (BOF) protein
A4R38_RS15360	COG3706	GGDEF domain
A4R38_RS15370	COG2814	Major facilitator Superfamily
A4R38_RS15375	COG0697	spore germination
A4R38_RS15385	COG4977	sequence-specific DNA binding
A4R38_RS15390	COG1846	Transcriptional regulator
A4R38_RS15405	COG0583	DNA-binding transcription factor activity
A4R38_RS15410	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS15415	COG2066	Belongs to the glutaminase family
A4R38_RS15425	COG2199	diguanylate cyclase activity
A4R38_RS15440	COG3781	membrane
A4R38_RS15450	COG1396	sequence-specific DNA binding
A4R38_RS15455	COG3550	peptidyl-serine autophosphorylation
A4R38_RS15460	COG3188	usher protein
A4R38_RS15465	COG3539	Fimbrial protein
A4R38_RS15470	COG3539	Fimbrial protein
A4R38_RS15475	COG3539	Fimbrial protein
A4R38_RS15480	COG0243	molybdopterin cofactor binding
A4R38_RS15490	COG2207	Transcriptional regulator
A4R38_RS15495	COG3119	arylsulfatase activity
A4R38_RS15500	COG0641	radical SAM
A4R38_RS15505	COG0612	Peptidase, M16
A4R38_RS15515	COG0076	glutamate decarboxylase activity
A4R38_RS15520	COG0531	amino acid
A4R38_RS15525	COG1649	PFAM Uncharacterised BCR, COG1649
A4R38_RS15530	COG3706	GGDEF domain
A4R38_RS15530	COG3706	GGDEF domain
A4R38_RS15535	COG2200	EAL domain
A4R38_RS15535	COG2199	diguanylate cyclase activity
A4R38_RS15535	COG2202	Pas domain
A4R38_RS15540	COG1764	response to oxidative stress
A4R38_RS15560	COG1064	alcohol dehydrogenase
A4R38_RS15570	COG3093	addiction module antidote protein HigA
A4R38_RS15575	COG2864	formate dehydrogenase
A4R38_RS15580	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS15585	COG0243	molybdopterin cofactor binding
A4R38_RS15585	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS15590	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS15590	COG0243	molybdopterin cofactor binding
A4R38_RS15595	COG0697	spore germination
A4R38_RS15600	COG2223	nitrite transmembrane transporter activity
A4R38_RS15605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4R38_RS15610	COG1140	nitrate reductase beta subunit
A4R38_RS15615	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4R38_RS15620	COG2181	nitrate reductase activity
A4R38_RS15625	COG0384	phenazine biosynthesis protein PhzF
A4R38_RS15630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4R38_RS15635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4R38_RS15640	COG5433	transposase activity
A4R38_RS15645	COG1113	amino acid transport
A4R38_RS15655	COG4772	TonB-dependent receptor
A4R38_RS15660	COG1802	Transcriptional regulator
A4R38_RS15665	COG1247	-acetyltransferase
A4R38_RS15670	COG3238	Protein conserved in bacteria
A4R38_RS15695	COG1177	transmembrane transport
A4R38_RS15700	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4R38_RS15705	COG3842	ATPase activity
A4R38_RS15710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4R38_RS15715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R38_RS15720	COG1598	PFAM Uncharacterised protein family UPF0150
A4R38_RS15730	COG0826	peptidase U32
A4R38_RS15735	COG1396	sequence-specific DNA binding
A4R38_RS15740	COG3135	benzoate transporter
A4R38_RS15750	COG0500	methyltransferase
A4R38_RS15755	COG1275	C4-dicarboxylate transporter malic acid transport protein
A4R38_RS15760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4R38_RS15765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS15770	COG2841	Protein conserved in bacteria
A4R38_RS15785	COG5383	Protein conserved in bacteria
A4R38_RS15790	COG0583	DNA-binding transcription factor activity
A4R38_RS15795	COG0840	transmembrane signaling receptor activity
A4R38_RS15815	COG3038	cytochrome b561
A4R38_RS15820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4R38_RS15825	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS15830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4R38_RS15835	COG1643	Atp-dependent helicase
A4R38_RS15845	COG0667	Aldo Keto reductase
A4R38_RS15860	COG3784	Protein of unknown function (DUF1318)
A4R38_RS15870	COG2911	Protein conserved in bacteria
A4R38_RS15875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4R38_RS15880	COG3187	Heat shock protein
A4R38_RS15885	COG3042	response to heat
A4R38_RS15890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R38_RS15890	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4R38_RS15890	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4R38_RS15890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4R38_RS15895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4R38_RS15900	COG0589	response to stress
A4R38_RS15910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS15915	COG0582	viral genome integration into host DNA
A4R38_RS15925	COG0513	Belongs to the DEAD box helicase family
A4R38_RS15940	COG3706	GGDEF domain
A4R38_RS15945	COG2840	Smr protein MutS2
A4R38_RS15960	COG2207	Transcriptional regulator
A4R38_RS15970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4R38_RS15975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R38_RS15980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS15985	COG0589	response to stress
A4R38_RS15990	COG3182	Iron-regulated membrane protein
A4R38_RS15995	COG0668	transmembrane transport
A4R38_RS16000	COG4166	transmembrane transport
A4R38_RS16010	COG0583	DNA-binding transcription factor activity
A4R38_RS16015	COG3677	Transposase
A4R38_RS16015	COG1662	PFAM IS1 transposase
A4R38_RS16020	COG1073	alpha beta
A4R38_RS16025	COG0702	epimerase
A4R38_RS16030	COG2866	Carboxypeptidase
A4R38_RS16035	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS16040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4R38_RS16045	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A4R38_RS16055	COG3106	COG3106 Predicted ATPase
A4R38_RS16060	COG1609	Transcriptional regulator
A4R38_RS16075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS16080	COG1554	hydrolase, family 65, central catalytic
A4R38_RS16085	COG0673	inositol 2-dehydrogenase activity
A4R38_RS16090	COG1082	Xylose isomerase domain protein TIM barrel
A4R38_RS16095	COG1063	alcohol dehydrogenase
A4R38_RS16100	COG0395	ABC-type sugar transport system, permease component
A4R38_RS16105	COG1175	transmembrane transport
A4R38_RS16110	COG1653	transport
A4R38_RS16115	COG0366	Alpha amylase catalytic
A4R38_RS16120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4R38_RS16130	COG1983	PspC domain protein
A4R38_RS16140	COG1842	Phage shock protein A
A4R38_RS16145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4R38_RS16160	COG4166	transmembrane transport
A4R38_RS16165	COG4168	peptide transport system, permease
A4R38_RS16170	COG4171	peptide transport system, permease
A4R38_RS16175	COG4172	Belongs to the ABC transporter superfamily
A4R38_RS16180	COG4172	Belongs to the ABC transporter superfamily
A4R38_RS16185	COG2814	Major facilitator Superfamily
A4R38_RS16195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS16200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS16210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4R38_RS16215	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R38_RS16215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R38_RS16230	COG5001	Diguanylate cyclase
A4R38_RS16240	COG1349	DNA-binding transcription factor activity
A4R38_RS16250	COG0023	Translation Initiation Factor
A4R38_RS16260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4R38_RS16265	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4R38_RS16270	COG0671	phosphoesterase, PA-phosphatase related
A4R38_RS16280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R38_RS16300	COG0583	DNA-binding transcription factor activity
A4R38_RS16305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4R38_RS16320	COG0616	signal peptide processing
A4R38_RS16330	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS16335	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4R38_RS16350	COG1187	pseudouridine synthase activity
A4R38_RS16355	COG4907	membrane protein (DUF2207)
A4R38_RS16360	COG0009	L-threonylcarbamoyladenylate synthase
A4R38_RS16365	COG0613	PHP domain protein
A4R38_RS16370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4R38_RS16375	COG0512	Glutamine amidotransferase of anthranilate synthase
A4R38_RS16375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4R38_RS16380	COG0135	phosphoribosylanthranilate isomerase activity
A4R38_RS16380	COG0134	indole-3-glycerol-phosphate synthase activity
A4R38_RS16395	COG3047	cAMP biosynthetic process
A4R38_RS16410	COG1607	acyl-coa hydrolase
A4R38_RS16420	COG2350	Protein conserved in bacteria
A4R38_RS16425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4R38_RS16445	COG4608	Belongs to the ABC transporter superfamily
A4R38_RS16450	COG0444	Belongs to the ABC transporter superfamily
A4R38_RS16455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS16460	COG0601	transmembrane transport
A4R38_RS16465	COG4166	transmembrane transport
A4R38_RS16470	COG2095	MarC family integral membrane protein
A4R38_RS16475	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS16475	COG1454	alcohol dehydrogenase
A4R38_RS16480	COG3385	transposase activity
A4R38_RS16485	COG3385	transposase activity
A4R38_RS16490	COG1435	thymidine kinase activity
A4R38_RS16500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4R38_RS16505	COG0745	RESPONSE REGULATOR receiver
A4R38_RS16510	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4R38_RS16520	COG0788	formyltetrahydrofolate deformylase activity
A4R38_RS16560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS16565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R38_RS16570	COG2181	nitrate reductase activity
A4R38_RS16575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4R38_RS16580	COG1140	nitrate reductase beta subunit
A4R38_RS16585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4R38_RS16590	COG2223	nitrite transmembrane transporter activity
A4R38_RS16600	COG3850	Histidine kinase
A4R38_RS16605	COG2197	response regulator
A4R38_RS16610	COG4932	domain protein
A4R38_RS16615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4R38_RS16620	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A4R38_RS16625	COG4572	Cation transport regulator
A4R38_RS16630	COG0387	Pfam Sodium calcium exchanger
A4R38_RS16645	COG2912	Transglutaminase-like superfamily
A4R38_RS16650	COG3094	Invasion gene expression up-regulator, SirB
A4R38_RS16655	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R38_RS16680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4R38_RS16685	COG0659	secondary active sulfate transmembrane transporter activity
A4R38_RS16700	COG0012	GTP binding
A4R38_RS16705	COG0582	viral genome integration into host DNA
A4R38_RS16715	COG2801	Transposase and inactivated derivatives
A4R38_RS16745	COG2826	transposase and inactivated derivatives, IS30 family
A4R38_RS16775	COG4974	Belongs to the 'phage' integrase family
A4R38_RS16780	COG2003	Belongs to the UPF0758 family
A4R38_RS16845	COG3284	Transcriptional regulator
A4R38_RS16850	COG2376	Dihydroxyacetone kinase
A4R38_RS16855	COG1461	Dihydroxyacetone kinase
A4R38_RS16860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS16860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A4R38_RS16860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS16870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R38_RS16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS16880	COG1120	ATPase activity
A4R38_RS16885	COG0500	methyltransferase
A4R38_RS16890	COG0157	Belongs to the NadC ModD family
A4R38_RS16905	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A4R38_RS16915	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4R38_RS16925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4R38_RS16935	COG2719	SpoVR family
A4R38_RS16945	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R38_RS16955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4R38_RS16960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4R38_RS16975	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R38_RS17005	COG2894	cell division
A4R38_RS17060	COG2200	EAL domain
A4R38_RS17085	COG2200	EAL domain
A4R38_RS17090	COG0789	Transcriptional regulator
A4R38_RS17095	COG5562	phage envelope protein
A4R38_RS17110	COG1121	(ABC) transporter
A4R38_RS17115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS17120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS17135	COG4372	Transposase
A4R38_RS17140	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS17150	COG5301	cellulose 1,4-beta-cellobiosidase activity
A4R38_RS17180	COG1196	nuclear chromosome segregation
A4R38_RS17250	COG4220	transposase activity
A4R38_RS17275	COG3772	lysozyme
A4R38_RS17340	COG2076	Multidrug Resistance protein
A4R38_RS17440	COG0582	viral genome integration into host DNA
A4R38_RS17445	COG0538	isocitrate dehydrogenase activity
A4R38_RS17450	COG1187	pseudouridine synthase activity
A4R38_RS17470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4R38_RS17480	COG2205	protein histidine kinase activity
A4R38_RS17485	COG2850	peptidyl-arginine hydroxylation
A4R38_RS17500	COG3842	ATPase activity
A4R38_RS17515	COG0500	methyltransferase
A4R38_RS17520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R38_RS17525	COG5301	cellulose 1,4-beta-cellobiosidase activity
A4R38_RS17635	COG4220	transposase activity
A4R38_RS17670	COG3772	lysozyme
A4R38_RS17720	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A4R38_RS17725	COG1403	HNH endonuclease
A4R38_RS17785	COG1846	Transcriptional regulator
A4R38_RS17790	COG1484	DNA-dependent DNA replication
A4R38_RS17795	COG1846	Transcriptional regulator
A4R38_RS17855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS17865	COG0582	viral genome integration into host DNA
A4R38_RS17870	COG1177	transmembrane transport
A4R38_RS17875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4R38_RS17885	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4R38_RS17890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4R38_RS17900	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4R38_RS17910	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4R38_RS17915	COG4763	Acyl-transferase
A4R38_RS17920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4R38_RS17925	COG1388	LysM domain
A4R38_RS17925	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS17935	COG1309	transcriptional regulator
A4R38_RS17940	COG3134	Outer membrane lipoprotein
A4R38_RS17945	COG1252	NADH dehydrogenase
A4R38_RS17960	COG0510	thiamine kinase activity
A4R38_RS17965	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A4R38_RS17970	COG5633	Lipoprotein
A4R38_RS17975	COG0537	adenosine 5'-monophosphoramidase activity
A4R38_RS17980	COG4773	Receptor
A4R38_RS17985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS17985	COG1263	PTS System
A4R38_RS17990	COG0084	hydrolase, TatD family'
A4R38_RS17995	COG0470	DNA polymerase III
A4R38_RS18005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4R38_RS18010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R38_RS18015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4R38_RS18025	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS18030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4R38_RS18050	COG1399	metal-binding, possibly nucleic acid-binding protein
A4R38_RS18055	COG0424	maF-like protein
A4R38_RS18060	COG0564	pseudouridine synthase activity
A4R38_RS18070	COG1530	ribonuclease E activity
A4R38_RS18075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4R38_RS18080	COG1256	bacterial-type flagellum assembly
A4R38_RS18085	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4R38_RS18085	COG3951	Flagellar rod assembly protein muramidase FlgJ
A4R38_RS18100	COG4786	Flagellar basal body rod
A4R38_RS18105	COG4787	bacterial-type flagellum-dependent cell motility
A4R38_RS18110	COG1749	Flagellar hook protein flgE
A4R38_RS18115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A4R38_RS18120	COG1558	bacterial-type flagellum-dependent cell motility
A4R38_RS18125	COG1815	bacterial-type flagellum-dependent cell motility
A4R38_RS18130	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A4R38_RS18135	COG2747	anti-sigma28 factor FlgM
A4R38_RS18140	COG3418	PFAM FlgN family protein
A4R38_RS18145	COG0728	peptidoglycan biosynthetic process
A4R38_RS18150	COG0673	inositol 2-dehydrogenase activity
A4R38_RS18160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS18170	COG2999	glutathione oxidoreductase activity
A4R38_RS18205	COG3038	cytochrome b561
A4R38_RS18210	COG2353	YceI-like domain
A4R38_RS18220	COG1560	Kdo2-lipid A biosynthetic process
A4R38_RS18240	COG5645	(Lipo)protein
A4R38_RS18245	COG2943	transferase activity, transferring hexosyl groups
A4R38_RS18270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS18275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R38_RS18305	COG2197	response regulator
A4R38_RS18320	COG1462	curli production assembly transport component CsgG
A4R38_RS18330	COG3381	protein complex oligomerization
A4R38_RS18355	COG3706	GGDEF domain
A4R38_RS18360	COG0457	Tetratricopeptide repeat
A4R38_RS18365	COG1649	PFAM Uncharacterised BCR, COG1649
A4R38_RS18365	COG0726	polysaccharide deacetylase
A4R38_RS18370	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS18375	COG3658	cytochrome
A4R38_RS18380	COG1702	phosphate starvation-inducible protein PhoH
A4R38_RS18400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R38_RS18410	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS18410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS18410	COG0506	proline dehydrogenase activity
A4R38_RS18415	COG1309	transcriptional regulator
A4R38_RS18450	COG2233	PERMEase
A4R38_RS18455	COG3729	General stress protein
A4R38_RS18495	COG0243	molybdopterin cofactor binding
A4R38_RS18500	COG3005	denitrification pathway
A4R38_RS18505	COG0745	RESPONSE REGULATOR receiver
A4R38_RS18510	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS18515	COG2205	protein histidine kinase activity
A4R38_RS18515	COG0784	Response regulator, receiver
A4R38_RS18515	COG2198	Histidine kinase
A4R38_RS18520	COG0348	domain, Protein
A4R38_RS18535	COG1278	Cold shock
A4R38_RS18540	COG1278	Cold shock
A4R38_RS18555	COG1294	oxidase, subunit
A4R38_RS18560	COG1271	oxidase subunit
A4R38_RS18565	COG1773	rubredoxin
A4R38_RS18570	COG1999	signal sequence binding
A4R38_RS18575	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4R38_RS18580	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A4R38_RS18585	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A4R38_RS18590	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A4R38_RS18600	COG0670	Belongs to the BI1 family
A4R38_RS18605	COG2920	part of a sulfur-relay system
A4R38_RS18610	COG1254	Belongs to the acylphosphatase family
A4R38_RS18625	COG1832	CoA-binding protein
A4R38_RS18645	COG0210	DNA helicase
A4R38_RS18650	COG3304	Inner membrane component domain
A4R38_RS18655	COG1289	transmembrane transporter activity
A4R38_RS18660	COG3070	regulator of competence-specific genes
A4R38_RS18685	COG1067	ATP-dependent peptidase activity
A4R38_RS18695	COG3130	regulation of translation
A4R38_RS18700	COG3009	Protein conserved in bacteria
A4R38_RS18705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4R38_RS18705	COG3008	intermembrane lipid transfer
A4R38_RS18710	COG2995	paraquat-inducible protein a
A4R38_RS18715	COG0488	(ABC) transporter
A4R38_RS18725	COG3217	Mosc domain protein beta barrel domain protein
A4R38_RS18725	COG0633	Ferredoxin
A4R38_RS18740	COG0431	NADPH-dependent FMN reductase
A4R38_RS18745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R38_RS18755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R38_RS18760	COG1116	anion transmembrane transporter activity
A4R38_RS18765	COG0308	aminopeptidase N
A4R38_RS18790	COG1448	Aminotransferase
A4R38_RS18795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R38_RS18800	COG3108	Peptidase M15
A4R38_RS18805	COG2989	Protein conserved in bacteria
A4R38_RS18815	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4R38_RS18825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4R38_RS18830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4R38_RS18835	COG3173	Aminoglycoside phosphotransferase
A4R38_RS18850	COG3214	Protein conserved in bacteria
A4R38_RS18865	COG0658	competence protein
A4R38_RS18865	COG2333	competence protein COMEC
A4R38_RS18875	COG0539	negative regulation of cytoplasmic translation
A4R38_RS18885	COG0501	Belongs to the peptidase M48B family
A4R38_RS18900	COG2323	membrane
A4R38_RS18905	COG1944	ATP diphosphatase activity
A4R38_RS18910	COG2116	formate transmembrane transporter activity
A4R38_RS18915	COG1882	Formate acetyltransferase
A4R38_RS18920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS18930	COG1335	isochorismatase
A4R38_RS18935	COG3302	dmso reductase anchor subunit
A4R38_RS18940	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS18945	COG0243	molybdopterin cofactor binding
A4R38_RS18955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4R38_RS18970	COG1522	sequence-specific DNA binding
A4R38_RS18975	COG0492	ferredoxin-NADP+ reductase activity
A4R38_RS18980	COG4988	ABC transporter
A4R38_RS18985	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4R38_RS19005	COG0542	response to heat
A4R38_RS19015	COG1278	Cold shock
A4R38_RS19025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS19030	COG2990	Protein conserved in bacteria
A4R38_RS19035	COG3593	DNA synthesis involved in DNA repair
A4R38_RS19045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4R38_RS19050	COG2431	L-lysine efflux transmembrane transporter activity
A4R38_RS19055	COG1151	hydroxylamine reductase activity
A4R38_RS19060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R38_RS19065	COG0028	Belongs to the TPP enzyme family
A4R38_RS19070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A4R38_RS19075	COG0702	epimerase
A4R38_RS19080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS19085	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS19100	COG1126	abc transporter atp-binding protein
A4R38_RS19105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS19110	COG4215	(ABC) transporter
A4R38_RS19115	COG4160	amino acid transport
A4R38_RS19120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS19135	COG1177	transmembrane transport
A4R38_RS19140	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4R38_RS19145	COG3842	ATPase activity
A4R38_RS19150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4R38_RS19170	COG0778	Nitroreductase
A4R38_RS19180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4R38_RS19195	COG3226	Transcriptional regulator
A4R38_RS19200	COG0738	Major facilitator superfamily
A4R38_RS19205	COG0561	phosphatase activity
A4R38_RS19215	COG2814	Major facilitator Superfamily
A4R38_RS19220	COG0671	phosphoesterase, PA-phosphatase related
A4R38_RS19225	COG1349	DNA-binding transcription factor activity
A4R38_RS19230	COG1686	Belongs to the peptidase S11 family
A4R38_RS19235	COG0625	glutathione transferase activity
A4R38_RS19240	COG2133	pyrroloquinoline quinone binding
A4R38_RS19255	COG2199	diguanylate cyclase activity
A4R38_RS19285	COG1446	asparaginase
A4R38_RS19290	COG0303	'Molybdopterin
A4R38_RS19295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4R38_RS19300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R38_RS19305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS19310	COG1882	Formate acetyltransferase
A4R38_RS19315	COG0561	phosphatase activity
A4R38_RS19320	COG0488	(ABC) transporter
A4R38_RS19325	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS19330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4R38_RS19335	COG1321	iron dependent repressor
A4R38_RS19345	COG2194	sulfuric ester hydrolase activity
A4R38_RS19350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4R38_RS19355	COG5006	permease, DMT superfamily
A4R38_RS19370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS19375	COG0765	amino acid transport
A4R38_RS19380	COG1126	abc transporter atp-binding protein
A4R38_RS19385	COG0668	transmembrane transport
A4R38_RS19405	COG3128	pkhd-type hydroxylase
A4R38_RS19410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4R38_RS19420	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS19425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4R38_RS19445	COG0513	Belongs to the DEAD box helicase family
A4R38_RS19450	COG1309	transcriptional regulator
A4R38_RS19460	COG1131	(ABC) transporter
A4R38_RS19465	COG0842	Transport permease protein
A4R38_RS19470	COG0842	Transport permease protein
A4R38_RS19480	COG3568	Endonuclease Exonuclease Phosphatase
A4R38_RS19485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS19490	COG0392	lysyltransferase activity
A4R38_RS19495	COG0670	Belongs to the BI1 family
A4R38_RS19500	COG0670	Belongs to the BI1 family
A4R38_RS19505	COG0314	molybdopterin synthase activity
A4R38_RS19510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4R38_RS19520	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4R38_RS19530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4R38_RS19540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R38_RS19545	COG2226	methyltransferase
A4R38_RS19560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R38_RS19565	COG1881	PFAM PEBP family protein
A4R38_RS19570	COG4677	pectinesterase activity
A4R38_RS19575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R38_RS19580	COG0471	metal ion transport
A4R38_RS19585	COG2828	Protein conserved in bacteria
A4R38_RS19590	COG0583	DNA-binding transcription factor activity
A4R38_RS19600	COG0561	phosphatase activity
A4R38_RS19605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4R38_RS19610	COG4149	molybdate abc transporter
A4R38_RS19615	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4R38_RS19625	COG2005	Transcriptional regulator
A4R38_RS19625	COG3585	molybdate ion transport
A4R38_RS19635	COG1119	ATPase activity
A4R38_RS19640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4R38_RS19645	COG1085	galactose-1-phosphate uridylyltransferase
A4R38_RS19655	COG2017	converts alpha-aldose to the beta-anomer
A4R38_RS19665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R38_RS19680	COG1230	cation diffusion facilitator family transporter
A4R38_RS19685	COG3201	nicotinamide mononucleotide transporter
A4R38_RS19690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4R38_RS19730	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A4R38_RS19735	COG2885	chlorophyll binding
A4R38_RS19745	COG3064	Membrane
A4R38_RS19750	COG0848	biopolymer transport protein
A4R38_RS19755	COG0811	peptide transport
A4R38_RS19760	COG0824	Thioesterase
A4R38_RS19765	COG3790	cyd operon protein YbgE
A4R38_RS19770	COG4890	Cyd operon protein YbgT
A4R38_RS19775	COG1294	oxidase, subunit
A4R38_RS19780	COG1271	oxidase subunit
A4R38_RS19795	COG0383	alpha-mannosidase activity
A4R38_RS19800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS19800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS19800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS19805	COG2188	Transcriptional regulator
A4R38_RS19810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS19820	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R38_RS19825	COG0567	Dehydrogenase, E1 component
A4R38_RS19835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R38_RS19840	COG1053	succinate dehydrogenase
A4R38_RS19845	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A4R38_RS19850	COG2009	succinate dehydrogenase
A4R38_RS19860	COG0372	Belongs to the citrate synthase family
A4R38_RS19865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4R38_RS19875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4R38_RS19880	COG2721	sulfolactate sulfo-lyase activity
A4R38_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS19895	COG1063	alcohol dehydrogenase
A4R38_RS19900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R38_RS19900	COG0473	3-isopropylmalate dehydrogenase activity
A4R38_RS19905	COG2186	Transcriptional regulator
A4R38_RS19910	COG3180	Ammonia monooxygenase
A4R38_RS19920	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4R38_RS19925	COG1984	allophanate hydrolase subunit 2
A4R38_RS19930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4R38_RS19935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4R38_RS19945	COG0415	Belongs to the DNA photolyase family
A4R38_RS19950	COG3272	Protein of unknown function (DUF1722)
A4R38_RS19980	COG2205	protein histidine kinase activity
A4R38_RS19985	COG0745	RESPONSE REGULATOR receiver
A4R38_RS19995	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS20000	COG0531	amino acid
A4R38_RS20005	COG0033	Phosphoglucomutase
A4R38_RS20010	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A4R38_RS20015	COG0596	Alpha beta hydrolase
A4R38_RS20025	COG0716	FMN binding
A4R38_RS20040	COG0735	belongs to the Fur family
A4R38_RS20060	COG1349	DNA-binding transcription factor activity
A4R38_RS20065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4R38_RS20070	COG3395	kinase activity
A4R38_RS20080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS20085	COG0861	Integral membrane protein TerC family
A4R38_RS20105	COG1263	PTS System
A4R38_RS20105	COG2190	(PTS) system
A4R38_RS20105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS20115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4R38_RS20120	COG1940	carbohydrate kinase activity
A4R38_RS20120	COG1846	Transcriptional regulator
A4R38_RS20125	COG0647	UMP catabolic process
A4R38_RS20130	COG0367	asparagine synthase
A4R38_RS20175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R38_RS20185	COG1702	phosphate starvation-inducible protein PhoH
A4R38_RS20195	COG4535	Mg2 and Co2 transporter CorC
A4R38_RS20200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4R38_RS20210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS20215	COG0765	amino acid transport
A4R38_RS20220	COG0765	amino acid transport
A4R38_RS20225	COG1126	abc transporter atp-binding protein
A4R38_RS20235	COG0443	Heat shock 70 kDa protein
A4R38_RS20240	COG2214	Heat shock protein DnaJ domain protein
A4R38_RS20250	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A4R38_RS20260	COG2888	peptidyl-tyrosine sulfation
A4R38_RS20275	COG1466	dna polymerase III delta subunit
A4R38_RS20285	COG0406	alpha-ribazole phosphatase activity
A4R38_RS20290	COG0799	negative regulation of ribosome biogenesis
A4R38_RS20300	COG0768	penicillin binding
A4R38_RS20305	COG0772	Belongs to the SEDS family
A4R38_RS20310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4R38_RS20315	COG1686	Belongs to the peptidase S11 family
A4R38_RS20335	COG0583	DNA-binding transcription factor activity
A4R38_RS20345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R38_RS20350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R38_RS20370	COG3069	C4-dicarboxylate transmembrane transporter activity
A4R38_RS20375	COG4565	transcriptional regulatory protein
A4R38_RS20380	COG3290	protein histidine kinase activity
A4R38_RS20385	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A4R38_RS20395	COG2301	Belongs to the HpcH HpaI aldolase family
A4R38_RS20400	COG3051	citrate lyase alpha subunit
A4R38_RS20415	COG0471	metal ion transport
A4R38_RS20420	COG3719	Belongs to the RNase T2 family
A4R38_RS20425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R38_RS20430	COG0589	response to stress
A4R38_RS20435	COG3634	alkyl hydroperoxide reductase activity
A4R38_RS20440	COG0450	alkyl hydroperoxide reductase
A4R38_RS20445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R38_RS20450	COG0583	DNA-binding transcription factor activity
A4R38_RS20455	COG3969	phosphoadenosine phosphosulfate
A4R38_RS20460	COG1475	DNA binding
A4R38_RS20465	COG0436	Aminotransferase
A4R38_RS20470	COG0371	Dehydrogenase
A4R38_RS20475	COG2879	small protein
A4R38_RS20480	COG1966	Carbon starvation protein
A4R38_RS20485	COG2050	protein possibly involved in aromatic compounds catabolism
A4R38_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS20495	COG3433	isochorismatase activity
A4R38_RS20495	COG1535	isochorismatase
A4R38_RS20500	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4R38_RS20505	COG1169	isochorismate synthase
A4R38_RS20510	COG4592	Periplasmic binding protein
A4R38_RS20520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS20525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS20530	COG1120	ATPase activity
A4R38_RS20535	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4R38_RS20540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A4R38_RS20540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R38_RS20545	COG3251	PFAM MbtH domain protein
A4R38_RS20550	COG2382	esterase
A4R38_RS20555	COG4771	TonB-dependent receptor
A4R38_RS20565	COG2977	Belongs to the P-Pant transferase superfamily
A4R38_RS20570	COG3958	Transketolase
A4R38_RS20575	COG3959	Transketolase, thiamine diphosphate binding domain
A4R38_RS20580	COG2390	Transcriptional regulator
A4R38_RS20585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4R38_RS20590	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS20600	COG1129	ABC transporter
A4R38_RS20605	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS20615	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS20630	COG2801	Transposase and inactivated derivatives
A4R38_RS20635	COG2963	transposase activity
A4R38_RS20655	COG2315	Protein conserved in bacteria
A4R38_RS20660	COG0778	Nitroreductase
A4R38_RS20665	COG0668	transmembrane transport
A4R38_RS20670	COG1113	amino acid transport
A4R38_RS20675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS20680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS20685	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS20690	COG1538	Outer membrane efflux protein
A4R38_RS20695	COG0745	RESPONSE REGULATOR receiver
A4R38_RS20700	COG5002	protein histidine kinase activity
A4R38_RS20705	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS20710	COG4783	chaperone-mediated protein folding
A4R38_RS20720	COG4571	Outer membrane protease
A4R38_RS20725	COG0500	methyltransferase
A4R38_RS20730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R38_RS20735	COG0582	viral genome integration into host DNA
A4R38_RS20755	COG2501	S4 domain
A4R38_RS20760	COG1988	membrane-bound metal-dependent
A4R38_RS20770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R38_RS20785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4R38_RS20790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4R38_RS20795	COG0549	Belongs to the carbamate kinase family
A4R38_RS20805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS20810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS20815	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS20820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R38_RS20825	COG3257	ureidoglycine aminohydrolase activity
A4R38_RS20830	COG1929	Belongs to the glycerate kinase type-1 family
A4R38_RS20835	COG2233	PERMEase
A4R38_RS20845	COG1953	Uracil, thiamine, allantoin
A4R38_RS20855	COG3622	Belongs to the hyi family
A4R38_RS20860	COG3960	tartronate-semialdehyde synthase activity
A4R38_RS20905	COG3157	Type VI secretion system effector, Hcp
A4R38_RS20910	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A4R38_RS20915	COG4181	ATPase activity
A4R38_RS20920	COG2755	lipolytic protein G-D-S-L family
A4R38_RS20925	COG0300	oxidoreductase activity
A4R38_RS20930	COG3118	belongs to the thioredoxin family
A4R38_RS20935	COG0390	transport system, permease component
A4R38_RS20940	COG4619	ABC transporter
A4R38_RS20945	COG0330	HflC and HflK could
A4R38_RS20950	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4R38_RS20965	COG0789	Transcriptional regulator
A4R38_RS20970	COG0531	amino acid
A4R38_RS20975	COG2066	Belongs to the glutaminase family
A4R38_RS20980	COG2217	Heavy metal translocating P-type atpase
A4R38_RS20985	COG3093	addiction module antidote protein HigA
A4R38_RS20990	COG3549	Plasmid maintenance system killer
A4R38_RS20995	COG3735	TraB family
A4R38_RS21000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4R38_RS21015	COG0737	Belongs to the 5'-nucleotidase family
A4R38_RS21020	COG2223	nitrite transmembrane transporter activity
A4R38_RS21025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4R38_RS21025	COG4651	solute:proton antiporter activity
A4R38_RS21030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS21065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4R38_RS21075	COG2832	Protein of unknown function (DUF454)
A4R38_RS21080	COG3923	Primosomal replication protein n
A4R38_RS21090	COG3264	Mechanosensitive ion channel
A4R38_RS21090	COG1196	nuclear chromosome segregation
A4R38_RS21095	COG1309	transcriptional regulator
A4R38_RS21100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS21105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS21120	COG0110	maltose O-acetyltransferase activity
A4R38_RS21130	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4R38_RS21135	COG5507	3-demethylubiquinone-9 3-methyltransferase
A4R38_RS21145	COG3695	enzyme binding
A4R38_RS21150	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A4R38_RS21155	COG1946	Acyl-CoA thioesterase
A4R38_RS21160	COG0004	ammonium transporteR
A4R38_RS21165	COG0347	Belongs to the P(II) protein family
A4R38_RS21170	COG1132	(ABC) transporter
A4R38_RS21175	COG1132	(ABC) transporter
A4R38_RS21180	COG1522	sequence-specific DNA binding
A4R38_RS21190	COG4533	DNA binding
A4R38_RS21200	COG0824	Thioesterase
A4R38_RS21205	COG1555	photosystem II stabilization
A4R38_RS21210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R38_RS21215	COG0776	regulation of translation
A4R38_RS21220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4R38_RS21245	COG0271	Belongs to the BolA IbaG family
A4R38_RS21250	COG3056	Lipoprotein
A4R38_RS21255	COG2223	nitrite transmembrane transporter activity
A4R38_RS21260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4R38_RS21265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4R38_RS21270	COG1845	cytochrome c oxidase, subunit III
A4R38_RS21275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4R38_RS21285	COG2814	Major facilitator Superfamily
A4R38_RS21295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4R38_RS21300	COG0693	protein deglycase activity
A4R38_RS21315	COG0142	geranyltranstransferase activity
A4R38_RS21325	COG0667	Aldo Keto reductase
A4R38_RS21330	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4R38_RS21335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4R38_RS21350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R38_RS21350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R38_RS21360	COG4238	major outer membrane lipoprotein
A4R38_RS21365	COG3248	Nucleoside-binding outer membrane protein
A4R38_RS21370	COG1403	HNH endonuclease
A4R38_RS21375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R38_RS21380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R38_RS21385	COG1862	Preprotein translocase
A4R38_RS21405	COG0366	Alpha amylase catalytic
A4R38_RS21410	COG1113	amino acid transport
A4R38_RS21415	COG1114	Component of the transport system for branched-chain amino acids
A4R38_RS21420	COG5002	protein histidine kinase activity
A4R38_RS21425	COG0745	RESPONSE REGULATOR receiver
A4R38_RS21430	COG0420	3'-5' exonuclease activity
A4R38_RS21435	COG0419	ATPase involved in DNA repair
A4R38_RS21440	COG2814	Major facilitator Superfamily
A4R38_RS21445	COG1940	carbohydrate kinase activity
A4R38_RS21470	COG4126	flavin adenine dinucleotide binding
A4R38_RS21495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4R38_RS21500	COG3706	GGDEF domain
A4R38_RS21510	COG1785	Belongs to the alkaline phosphatase family
A4R38_RS21520	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R38_RS21540	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A4R38_RS21550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R38_RS21555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS21560	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS21565	COG0113	porphobilinogen synthase activity
A4R38_RS21570	COG2175	clavaminate synthase activity
A4R38_RS21575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R38_RS21585	COG4521	taurine ABC transporter
A4R38_RS21605	COG3122	Protein conserved in bacteria
A4R38_RS21610	COG2814	Major facilitator Superfamily
A4R38_RS21615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R38_RS21645	COG1414	Transcriptional regulator
A4R38_RS21650	COG1609	Transcriptional regulator
A4R38_RS21660	COG2223	nitrite transmembrane transporter activity
A4R38_RS21665	COG0110	maltose O-acetyltransferase activity
A4R38_RS21670	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS21675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4R38_RS21680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R38_RS21685	COG2079	MmgE PrpD family protein
A4R38_RS21690	COG0372	Belongs to the citrate synthase family
A4R38_RS21695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4R38_RS21710	COG1280	lysine exporter protein (LysE YggA)
A4R38_RS21715	COG1064	alcohol dehydrogenase
A4R38_RS21720	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS21725	COG0549	Belongs to the carbamate kinase family
A4R38_RS21730	COG1304	FMN binding
A4R38_RS21735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS21745	COG0666	response to abiotic stimulus
A4R38_RS21755	COG0583	DNA-binding transcription factor activity
A4R38_RS21760	COG2200	EAL domain
A4R38_RS21760	COG2771	luxR family
A4R38_RS21770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4R38_RS21780	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS21795	COG0582	viral genome integration into host DNA
A4R38_RS21800	COG2200	EAL domain
A4R38_RS21800	COG2771	luxR family
A4R38_RS21825	COG1556	Lactate utilization protein
A4R38_RS21830	COG1139	Iron-sulfur cluster binding protein
A4R38_RS21835	COG0247	lactate metabolic process
A4R38_RS21840	COG2207	Transcriptional regulator
A4R38_RS21845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS21855	COG3059	membrane
A4R38_RS21860	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS21865	COG3708	Transcriptional regulator
A4R38_RS21865	COG2207	Transcriptional regulator
A4R38_RS21870	COG2373	Large extracellular alpha-helical protein
A4R38_RS21870	COG1388	LysM domain
A4R38_RS21870	COG4932	domain protein
A4R38_RS21875	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS21880	COG0667	Aldo Keto reductase
A4R38_RS21890	COG0583	DNA-binding transcription factor activity
A4R38_RS21895	COG1073	alpha beta
A4R38_RS21900	COG1902	pentaerythritol trinitrate reductase activity
A4R38_RS21950	COG0727	PFAM Uncharacterised protein family (UPF0153)
A4R38_RS21955	COG3477	response to acidic pH
A4R38_RS21970	COG4974	Belongs to the 'phage' integrase family
A4R38_RS21995	COG0732	type I restriction modification DNA specificity domain
A4R38_RS22020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4R38_RS22040	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4R38_RS22045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R38_RS22050	COG1690	Belongs to the RtcB family
A4R38_RS22055	COG0454	-acetyltransferase
A4R38_RS22075	COG1943	Transposase
A4R38_RS22080	COG0791	NLP P60 protein
A4R38_RS22085	COG3034	peptidoglycan biosynthetic process
A4R38_RS22090	COG0121	glutamine amidotransferase
A4R38_RS22100	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS22110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R38_RS22120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS22130	COG2226	methyltransferase
A4R38_RS22140	COG1388	LysM domain
A4R38_RS22140	COG0741	lytic transglycosylase activity
A4R38_RS22145	COG2226	methyltransferase
A4R38_RS22155	COG0583	DNA-binding transcription factor activity
A4R38_RS22160	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS22195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4R38_RS22200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4R38_RS22205	COG2011	ABC-type metal ion transport system permease component
A4R38_RS22210	COG1464	Belongs to the NlpA lipoprotein family
A4R38_RS22220	COG1720	tRNA m6t6A37 methyltransferase activity
A4R38_RS22230	COG0791	NLP P60 protein
A4R38_RS22235	COG3015	lipoprotein NlpE involved in copper resistance
A4R38_RS22240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R38_RS22245	COG4681	YaeQ
A4R38_RS22255	COG4568	rho-dependent transcription termination
A4R38_RS22260	COG0037	tRNA processing
A4R38_RS22265	COG0346	lactoylglutathione lyase activity
A4R38_RS22270	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS22280	COG0587	DNA-directed DNA polymerase activity
A4R38_RS22305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4R38_RS22310	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A4R38_RS22320	COG0750	zinc metalloprotease
A4R38_RS22325	COG0575	Belongs to the CDS family
A4R38_RS22330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4R38_RS22335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4R38_RS22360	COG0024	Methionine aminopeptidase
A4R38_RS22380	COG3835	regulator
A4R38_RS22385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R38_RS22400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R38_RS22405	COG2860	membrane
A4R38_RS22425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS22430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R38_RS22435	COG1120	ATPase activity
A4R38_RS22440	COG4774	siderophore transport
A4R38_RS22455	COG3121	Chaperone
A4R38_RS22465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4R38_RS22470	COG1643	Atp-dependent helicase
A4R38_RS22475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A4R38_RS22485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4R38_RS22490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4R38_RS22495	COG0617	tRNA 3'-terminal CCA addition
A4R38_RS22500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4R38_RS22505	COG3539	Fimbrial protein
A4R38_RS22510	COG3121	Chaperone
A4R38_RS22515	COG3188	usher protein
A4R38_RS22520	COG3539	Fimbrial protein
A4R38_RS22525	COG3539	Fimbrial protein
A4R38_RS22530	COG3539	Fimbrial protein
A4R38_RS22535	COG3539	Fimbrial protein
A4R38_RS22545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4R38_RS22550	COG5464	transposase or invertase
A4R38_RS22555	COG5464	transposase or invertase
A4R38_RS22565	COG0726	polysaccharide deacetylase
A4R38_RS22570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS22575	COG0842	Transport permease protein
A4R38_RS22580	COG1131	(ABC) transporter
A4R38_RS22585	COG0288	reversible hydration of carbon dioxide
A4R38_RS22590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4R38_RS22595	COG4993	Dehydrogenase
A4R38_RS22600	COG2132	Multicopper oxidase
A4R38_RS22625	COG1049	propionate catabolic process, 2-methylcitrate cycle
A4R38_RS22630	COG3064	Membrane
A4R38_RS22630	COG3064	Membrane
A4R38_RS22635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS22640	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R38_RS22645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4R38_RS22650	COG2186	Transcriptional regulator
A4R38_RS22690	COG3157	Type VI secretion system effector, Hcp
A4R38_RS22695	COG1113	amino acid transport
A4R38_RS22700	COG3725	Membrane protein required for beta-lactamase induction
A4R38_RS22705	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS22710	COG0157	Belongs to the NadC ModD family
A4R38_RS22720	COG4969	Belongs to the N-Me-Phe pilin family
A4R38_RS22725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4R38_RS22730	COG1459	type II secretion system
A4R38_RS22740	COG0237	dephospho-CoA kinase activity
A4R38_RS22755	COG0494	nUDIX hydrolase
A4R38_RS22775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4R38_RS22780	COG0849	cell division
A4R38_RS22785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4R38_RS22790	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R38_RS22805	COG0772	Belongs to the SEDS family
A4R38_RS22820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4R38_RS22825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4R38_RS22830	COG0768	penicillin binding
A4R38_RS22835	COG3116	cell division
A4R38_RS22850	COG1609	Transcriptional regulator
A4R38_RS22860	COG0440	acetolactate synthase activity
A4R38_RS22865	COG0028	Belongs to the TPP enzyme family
A4R38_RS22870	COG0583	DNA-binding transcription factor activity
A4R38_RS22910	COG4143	(ABC) transporter
A4R38_RS22915	COG1178	ABC-type Fe3 transport system permease component
A4R38_RS22925	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS22940	COG3181	Tripartite tricarboxylate transporter family receptor
A4R38_RS22945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS22950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS22955	COG4977	sequence-specific DNA binding
A4R38_RS22970	COG0235	Class ii aldolase
A4R38_RS22975	COG0417	DNA replication proofreading
A4R38_RS22985	COG0564	pseudouridine synthase activity
A4R38_RS22990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4R38_RS23000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R38_RS23005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4R38_RS23035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4R38_RS23050	COG2271	Major facilitator Superfamily
A4R38_RS23055	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4R38_RS23060	COG0644	oxidoreductase
A4R38_RS23115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4R38_RS23120	COG0505	Belongs to the CarA family
A4R38_RS23155	COG1047	Peptidyl-prolyl cis-trans
A4R38_RS23170	COG0196	riboflavin kinase activity
A4R38_RS23195	COG0583	DNA-binding transcription factor activity
A4R38_RS23210	COG3119	arylsulfatase activity
A4R38_RS23220	COG1662	PFAM IS1 transposase
A4R38_RS23250	COG4735	regulation of single-species biofilm formation
A4R38_RS23255	COG1584	GPR1 FUN34 yaaH family protein
A4R38_RS23260	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4R38_RS23270	COG1115	amino acid carrier protein
A4R38_RS23290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4R38_RS23300	COG0460	homoserine dehydrogenase
A4R38_RS23300	COG0527	aspartate kinase activity
A4R38_RS23310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4R38_RS23320	COG0745	RESPONSE REGULATOR receiver
A4R38_RS23325	COG4452	Inner membrane protein CreD
A4R38_RS23330	COG2205	protein histidine kinase activity
A4R38_RS23335	COG0745	RESPONSE REGULATOR receiver
A4R38_RS23340	COG3045	CreA protein
A4R38_RS23345	COG3708	Transcriptional regulator
A4R38_RS23345	COG2207	Transcriptional regulator
A4R38_RS23365	COG0741	lytic transglycosylase activity
A4R38_RS23370	COG0488	(ABC) transporter
A4R38_RS23380	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A4R38_RS23385	COG3172	ATPase kinase involved in NAD metabolism
A4R38_RS23385	COG1056	cytidyltransferase-related domain
A4R38_RS23390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4R38_RS23395	COG0560	Phosphoserine phosphatase
A4R38_RS23400	COG3726	membrane protein affecting hemolysin expression
A4R38_RS23440	COG1328	CTP reductase activity
A4R38_RS23445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS23450	COG0084	hydrolase, TatD family'
A4R38_RS23455	COG4667	esterase of the alpha-beta hydrolase superfamily
A4R38_RS23465	COG2823	Periplasmic or secreted lipoprotein
A4R38_RS23475	COG1011	Hydrolase
A4R38_RS23480	COG0456	acetyltransferase
A4R38_RS23485	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4R38_RS23520	COG4114	ferric iron reductase
A4R38_RS23525	COG2197	response regulator
A4R38_RS23530	COG2197	response regulator
A4R38_RS23535	COG2966	Psort location CytoplasmicMembrane, score
A4R38_RS23550	COG1484	DNA-dependent DNA replication
A4R38_RS23565	COG1063	alcohol dehydrogenase
A4R38_RS23570	COG1802	Transcriptional regulator
A4R38_RS23575	COG2271	Major facilitator Superfamily
A4R38_RS23580	COG0840	transmembrane signaling receptor activity
A4R38_RS23590	COG1966	Carbon starvation protein
A4R38_RS23595	COG2879	small protein
A4R38_RS23600	COG0523	cobalamin synthesis protein
A4R38_RS23625	COG2814	Major facilitator Superfamily
A4R38_RS23630	COG2733	membrane
A4R38_RS23635	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
A4R38_RS23640	COG1924	4 iron, 4 sulfur cluster binding
A4R38_RS23655	COG0477	Major facilitator Superfamily
A4R38_RS23665	COG3366	ferrous iron transmembrane transporter activity
A4R38_RS23670	COG0700	Nucleoside recognition
A4R38_RS23675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4R38_RS23680	COG0583	DNA-binding transcription factor activity
A4R38_RS23705	COG2186	Transcriptional regulator
A4R38_RS23715	COG0246	Mannitol dehydrogenase
A4R38_RS23730	COG2610	gluconate transmembrane transporter activity
A4R38_RS23735	COG3539	Fimbrial protein
A4R38_RS23740	COG3539	Fimbrial protein
A4R38_RS23745	COG3539	Fimbrial protein
A4R38_RS23750	COG3188	usher protein
A4R38_RS23755	COG3121	Chaperone
A4R38_RS23760	COG3539	Fimbrial protein
A4R38_RS23775	COG4974	Belongs to the 'phage' integrase family
A4R38_RS23780	COG0582	viral genome integration into host DNA
A4R38_RS23795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4R38_RS23800	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A4R38_RS23810	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4R38_RS23810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS23820	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS23825	COG4372	Transposase
A4R38_RS23830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS23830	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4R38_RS23845	COG3153	acetyltransferase
A4R38_RS23850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4R38_RS23860	COG1363	Peptidase, m42
A4R38_RS23865	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS23870	COG3775	system Galactitol-specific IIC component
A4R38_RS23875	COG0434	BtpA family
A4R38_RS23880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS23885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4R38_RS23890	COG1349	DNA-binding transcription factor activity
A4R38_RS23895	COG1414	Transcriptional regulator
A4R38_RS23900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS23905	COG0129	dihydroxy-acid dehydratase activity
A4R38_RS23910	COG2610	gluconate transmembrane transporter activity
A4R38_RS23920	COG2390	Transcriptional regulator
A4R38_RS23945	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS23950	COG1401	restriction endodeoxyribonuclease activity
A4R38_RS24010	COG2003	Belongs to the UPF0758 family
A4R38_RS24035	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS24040	COG4584	PFAM Integrase catalytic
A4R38_RS24045	COG1484	DNA-dependent DNA replication
A4R38_RS24050	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS24120	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS24125	COG4372	Transposase
A4R38_RS24135	COG0440	acetolactate synthase activity
A4R38_RS24140	COG0440	acetolactate synthase activity
A4R38_RS24145	COG1349	DNA-binding transcription factor activity
A4R38_RS24155	COG0738	Major facilitator superfamily
A4R38_RS24170	COG3037	sugar-specific permease SgaT UlaA
A4R38_RS24180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS24210	COG1289	transmembrane transporter activity
A4R38_RS24220	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4R38_RS24225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS24225	COG2190	(PTS) system
A4R38_RS24225	COG1263	PTS System
A4R38_RS24230	COG1737	Transcriptional regulator
A4R38_RS24255	COG3177	Filamentation induced by cAMP protein fic
A4R38_RS24270	COG3335	DDE superfamily endonuclease
A4R38_RS24285	COG2205	protein histidine kinase activity
A4R38_RS24305	COG4227	nucleotidyltransferase activity
A4R38_RS24330	COG1064	alcohol dehydrogenase
A4R38_RS24335	COG3265	gluconokinase activity
A4R38_RS24340	COG1063	alcohol dehydrogenase
A4R38_RS24345	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS24350	COG2610	gluconate transmembrane transporter activity
A4R38_RS24355	COG1609	Transcriptional regulator
A4R38_RS24365	COG0795	lipopolysaccharide-transporting ATPase activity
A4R38_RS24370	COG0795	lipopolysaccharide-transporting ATPase activity
A4R38_RS24380	COG2927	DNA polymerase III (CHI subunit)
A4R38_RS24385	COG0525	valine-tRNA ligase activity
A4R38_RS24395	COG0456	acetyltransferase
A4R38_RS24400	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A4R38_RS24405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4R38_RS24410	COG2731	YhcH YjgK YiaL family protein
A4R38_RS24420	COG0549	Belongs to the carbamate kinase family
A4R38_RS24425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4R38_RS24430	COG1288	antiporter activity
A4R38_RS24435	COG1438	arginine binding
A4R38_RS24455	COG0251	oxidation-reduction process
A4R38_RS24460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4R38_RS24465	COG1609	Transcriptional regulator
A4R38_RS24470	COG1263	PTS System
A4R38_RS24470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS24475	COG0366	Alpha amylase catalytic
A4R38_RS24485	COG1328	CTP reductase activity
A4R38_RS24490	COG0602	queuosine metabolic process
A4R38_RS24495	COG3783	Cytochrome b(562)
A4R38_RS24500	COG0312	modulator of DNA gyrase
A4R38_RS24510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4R38_RS24520	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS24525	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS24530	COG1129	ABC transporter
A4R38_RS24535	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS24540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4R38_RS24545	COG2105	PFAM AIG2 family protein
A4R38_RS24550	COG2911	Protein conserved in bacteria
A4R38_RS24555	COG0729	surface antigen
A4R38_RS24570	COG1253	flavin adenine dinucleotide binding
A4R38_RS24580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4R38_RS24585	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4R38_RS24590	COG0737	Belongs to the 5'-nucleotidase family
A4R38_RS24595	COG1733	regulation of RNA biosynthetic process
A4R38_RS24600	COG0702	epimerase
A4R38_RS24605	COG0697	spore germination
A4R38_RS24615	COG1113	amino acid transport
A4R38_RS24620	COG0545	Peptidyl-prolyl cis-trans isomerase
A4R38_RS24625	COG3061	Opacity-associated protein A
A4R38_RS24630	COG1309	transcriptional regulator
A4R38_RS24645	COG1024	Enoyl-CoA hydratase
A4R38_RS24650	COG4670	ketone body catabolic process
A4R38_RS24655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4R38_RS24660	COG2271	Major facilitator Superfamily
A4R38_RS24680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4R38_RS24790	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS24840	COG0557	exoribonuclease II activity
A4R38_RS24905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4R38_RS24905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration