locus-tag	class	description
A4R38_RS00005	COG0235	Class ii aldolase
A4R38_RS00025	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS00030	COG3037	sugar-specific permease SgaT UlaA
A4R38_RS00045	COG1073	alpha beta
A4R38_RS00050	COG3650	response to hydrogen peroxide
A4R38_RS00055	COG1662	PFAM IS1 transposase
A4R38_RS00065	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS00070	COG0754	glutathionylspermidine amidase activity
A4R38_RS00075	COG5463	Belongs to the UPF0441 family
A4R38_RS00080	COG3766	membrane
A4R38_RS00090	COG1842	Phage shock protein A
A4R38_RS00095	COG3789	protein conserved in bacteria
A4R38_RS00100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R38_RS00105	COG0557	exoribonuclease II activity
A4R38_RS00120	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A4R38_RS00125	COG0330	HflC and HflK could
A4R38_RS00130	COG0330	HflC and HflK could
A4R38_RS00135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4R38_RS00155	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS00160	COG0802	atpase or kinase
A4R38_RS00165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4R38_RS00165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4R38_RS00170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4R38_RS00205	COG3264	Mechanosensitive ion channel
A4R38_RS00205	COG1511	domain protein
A4R38_RS00215	COG0531	amino acid
A4R38_RS00225	COG1053	succinate dehydrogenase
A4R38_RS00230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R38_RS00245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R38_RS00250	COG3040	lipid binding
A4R38_RS00255	COG2076	Multidrug Resistance protein
A4R38_RS00260	COG5510	response to toxic substance
A4R38_RS00265	COG5510	response to toxic substance
A4R38_RS00275	COG1509	lysine 2,3-aminomutase activity
A4R38_RS00300	COG0531	amino acid
A4R38_RS00305	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4R38_RS00310	COG1027	Aspartate ammonia-lyase
A4R38_RS00315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4R38_RS00325	COG4232	protein-disulfide reductase activity
A4R38_RS00330	COG1309	transcriptional regulator
A4R38_RS00340	COG3710	Transcriptional regulator
A4R38_RS00345	COG0531	amino acid
A4R38_RS00350	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS00355	COG3104	oligopeptide transport
A4R38_RS00360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4R38_RS00375	COG2388	GCN5-related N-acetyl-transferase
A4R38_RS00390	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS00390	COG3210	domain, Protein
A4R38_RS00400	COG3121	Chaperone
A4R38_RS00410	COG2388	GCN5-related N-acetyl-transferase
A4R38_RS00415	COG3592	Divergent 4Fe-4S mono-cluster
A4R38_RS00420	COG3290	protein histidine kinase activity
A4R38_RS00425	COG4565	transcriptional regulatory protein
A4R38_RS00435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4R38_RS00440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS00440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS00445	COG3647	Membrane
A4R38_RS00450	COG1486	melibiose metabolic process
A4R38_RS00460	COG2169	Transcriptional regulator
A4R38_RS00465	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS00470	COG2207	Transcriptional regulator
A4R38_RS00475	COG0531	amino acid
A4R38_RS00480	COG2194	sulfuric ester hydrolase activity
A4R38_RS00485	COG0745	RESPONSE REGULATOR receiver
A4R38_RS00490	COG0642	Histidine kinase
A4R38_RS00500	COG0477	Major facilitator Superfamily
A4R38_RS00515	COG2824	Alkylphosphonate utilization operon protein PhnA
A4R38_RS00520	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A4R38_RS00530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A4R38_RS00535	COG3639	organic phosphonate transmembrane transporter activity
A4R38_RS00540	COG2188	Transcriptional regulator
A4R38_RS00545	COG3624	Phosphonate C-P lyase system protein PhnG
A4R38_RS00550	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A4R38_RS00555	COG3626	phosphonate metabolism
A4R38_RS00560	COG3627	carbon phosphorus lyase activity
A4R38_RS00565	COG4107	phosphonate C-P lyase system protein PhnK
A4R38_RS00570	COG4778	phosphonate C-P lyase system protein PhnL
A4R38_RS00575	COG3454	Phosphonate metabolism
A4R38_RS00585	COG0456	acetyltransferase
A4R38_RS00590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4R38_RS00600	COG0698	ribose 5-phosphate isomerase
A4R38_RS00605	COG1737	Transcriptional regulator
A4R38_RS00610	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS00615	COG1129	ABC transporter
A4R38_RS00620	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS00625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4R38_RS00630	COG1940	carbohydrate kinase activity
A4R38_RS00635	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A4R38_RS00645	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS00650	COG1289	transmembrane transporter activity
A4R38_RS00660	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS00665	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS00675	COG0601	transmembrane transport
A4R38_RS00680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS00685	COG0444	Belongs to the ABC transporter superfamily
A4R38_RS00690	COG4608	Belongs to the ABC transporter superfamily
A4R38_RS00695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A4R38_RS00700	COG1301	dicarboxylic acid transport
A4R38_RS00705	COG4235	cytochrome complex assembly
A4R38_RS00710	COG3088	subunit of a heme lyase
A4R38_RS00715	COG1138	Cytochrome C-type biogenesis protein
A4R38_RS00720	COG3301	Polysulphide reductase, NrfD
A4R38_RS00725	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS00730	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4R38_RS00740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R38_RS00745	COG3162	membrane
A4R38_RS00755	COG1346	cytolysis
A4R38_RS00760	COG1380	Effector of murein hydrolase LrgA
A4R38_RS00765	COG0583	DNA-binding transcription factor activity
A4R38_RS00770	COG0025	NhaP-type Na H and K H
A4R38_RS00775	COG2252	PERMEase
A4R38_RS00780	COG0789	Transcriptional regulator
A4R38_RS00785	COG2207	Transcriptional regulator
A4R38_RS00790	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4R38_RS00800	COG0629	single-stranded DNA binding
A4R38_RS00805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R38_RS00810	COG2315	Protein conserved in bacteria
A4R38_RS00815	COG0432	Pfam Uncharacterised protein family UPF0047
A4R38_RS00820	COG3700	Belongs to the class B bacterial acid phosphatase family
A4R38_RS00830	COG2204	response regulator
A4R38_RS00835	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS00840	COG0471	metal ion transport
A4R38_RS00845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS00850	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R38_RS00855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS00865	COG0567	Dehydrogenase, E1 component
A4R38_RS00870	COG1448	Aminotransferase
A4R38_RS00880	COG3201	nicotinamide mononucleotide transporter
A4R38_RS00885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4R38_RS00890	COG0305	Participates in initiation and elongation during chromosome replication
A4R38_RS00895	COG1609	Transcriptional regulator
A4R38_RS00905	COG1024	Enoyl-CoA hydratase
A4R38_RS00910	COG1914	H( )-stimulated, divalent metal cation uptake system
A4R38_RS00915	COG1053	succinate dehydrogenase
A4R38_RS00920	COG0604	alcohol dehydrogenase
A4R38_RS00930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4R38_RS00935	COG0735	belongs to the Fur family
A4R38_RS00940	COG3237	CsbD-like
A4R38_RS00945	COG0534	Mate efflux family protein
A4R38_RS00955	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4R38_RS00985	COG3842	ATPase activity
A4R38_RS00995	COG2182	Extracellular solute-binding protein
A4R38_RS01000	COG1175	transmembrane transport
A4R38_RS01005	COG3833	ABC-type maltose transport systems, permease component
A4R38_RS01025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS01050	COG0527	aspartate kinase activity
A4R38_RS01060	COG1187	pseudouridine synthase activity
A4R38_RS01110	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4R38_RS01120	COG0646	methionine synthase
A4R38_RS01120	COG1410	methionine synthase
A4R38_RS01125	COG1414	Transcriptional regulator
A4R38_RS01135	COG2224	Isocitrate lyase
A4R38_RS01140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4R38_RS01150	COG0456	acetyltransferase
A4R38_RS01195	COG0151	Belongs to the GarS family
A4R38_RS01200	COG2204	response regulator
A4R38_RS01205	COG4191	Histidine kinase
A4R38_RS01210	COG3678	ATP-independent chaperone mediated protein folding
A4R38_RS01225	COG3068	Protein conserved in bacteria
A4R38_RS01260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4R38_RS01265	COG2104	thiamine diphosphate biosynthetic process
A4R38_RS01275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4R38_RS01310	COG0250	Participates in transcription elongation, termination and antitermination
A4R38_RS01315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4R38_RS01355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4R38_RS01355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4R38_RS01415	COG0477	Major facilitator Superfamily
A4R38_RS01420	COG1473	amidohydrolase
A4R38_RS01430	COG0583	DNA-binding transcription factor activity
A4R38_RS01445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4R38_RS01460	COG2194	sulfuric ester hydrolase activity
A4R38_RS01465	COG2207	Transcriptional regulator
A4R38_RS01470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS01480	COG1882	Formate acetyltransferase
A4R38_RS01485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS01495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R38_RS01505	COG0371	Dehydrogenase
A4R38_RS01515	COG3738	Protein conserved in bacteria
A4R38_RS01520	COG0697	spore germination
A4R38_RS01530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4R38_RS01535	COG0737	Belongs to the 5'-nucleotidase family
A4R38_RS01545	COG0460	homoserine dehydrogenase
A4R38_RS01545	COG0527	aspartate kinase activity
A4R38_RS01550	COG0626	cystathionine gamma-synthase activity
A4R38_RS01560	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A4R38_RS01570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4R38_RS01575	COG1609	Transcriptional regulator
A4R38_RS01580	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4R38_RS01595	COG1575	Belongs to the MenA family. Type 1 subfamily
A4R38_RS01610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4R38_RS01620	COG1494	fructose-1,6-bisphosphatase
A4R38_RS01630	COG0589	response to stress
A4R38_RS01635	COG3691	Protein conserved in bacteria
A4R38_RS01640	COG3152	Membrane
A4R38_RS01660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A4R38_RS01675	COG3678	ATP-independent chaperone mediated protein folding
A4R38_RS01680	COG0745	RESPONSE REGULATOR receiver
A4R38_RS01685	COG2205	protein histidine kinase activity
A4R38_RS01690	COG2258	MOSC domain
A4R38_RS01705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4R38_RS01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS01765	COG1363	Peptidase, m42
A4R38_RS01770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS01770	COG3711	transcriptional antiterminator
A4R38_RS01785	COG0326	Molecular chaperone. Has ATPase activity
A4R38_RS01795	COG0243	molybdopterin cofactor binding
A4R38_RS01795	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS01800	COG0243	molybdopterin cofactor binding
A4R38_RS01800	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS01805	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS01810	COG2864	formate dehydrogenase
A4R38_RS01820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS01835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS01865	COG0456	acetyltransferase
A4R38_RS01880	COG1011	Hydrolase
A4R38_RS01885	COG1349	DNA-binding transcription factor activity
A4R38_RS01890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS01895	COG2084	Dehydrogenase
A4R38_RS01900	COG3684	Belongs to the aldolase LacD family
A4R38_RS01905	COG2942	2-epimerase
A4R38_RS01910	COG2017	converts alpha-aldose to the beta-anomer
A4R38_RS01920	COG1501	Belongs to the glycosyl hydrolase 31 family
A4R38_RS01925	COG2211	Major facilitator Superfamily
A4R38_RS01930	COG2211	Major facilitator Superfamily
A4R38_RS01935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4R38_RS01940	COG1217	gtp-binding protein TYPA
A4R38_RS01950	COG0174	glutamine synthetase
A4R38_RS01955	COG3852	Histidine kinase
A4R38_RS01960	COG2204	response regulator
A4R38_RS01970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4R38_RS01985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4R38_RS01985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4R38_RS01995	COG0204	Acyl-transferase
A4R38_RS02000	COG5339	Protein conserved in bacteria
A4R38_RS02005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R38_RS02010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4R38_RS02015	COG3084	Protein conserved in bacteria
A4R38_RS02020	COG0746	molybdenum cofactor guanylyltransferase activity
A4R38_RS02025	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4R38_RS02050	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A4R38_RS02055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4R38_RS02060	COG1739	Uncharacterized protein family UPF0029
A4R38_RS02080	COG0543	2 iron, 2 sulfur cluster binding
A4R38_RS02085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4R38_RS02100	COG0805	protein transport
A4R38_RS02110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R38_RS02120	COG3165	ubiquinone biosynthetic process from chorismate
A4R38_RS02130	COG1322	Protein conserved in bacteria
A4R38_RS02135	COG1414	Transcriptional regulator
A4R38_RS02140	COG3734	2-keto-3-deoxy-galactonokinase
A4R38_RS02145	COG0800	Aldolase
A4R38_RS02165	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4R38_RS02170	COG0412	Dienelactone hydrolase
A4R38_RS02180	COG1335	isochorismatase
A4R38_RS02190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS02195	COG1304	FMN binding
A4R38_RS02200	COG0549	Belongs to the carbamate kinase family
A4R38_RS02210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4R38_RS02215	COG0583	DNA-binding transcription factor activity
A4R38_RS02220	COG1737	Transcriptional regulator
A4R38_RS02225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4R38_RS02230	COG2190	(PTS) system
A4R38_RS02230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS02230	COG1263	PTS System
A4R38_RS02245	COG0583	DNA-binding transcription factor activity
A4R38_RS02250	COG0697	spore germination
A4R38_RS02255	COG0561	phosphatase activity
A4R38_RS02260	COG2267	carboxylic ester hydrolase activity
A4R38_RS02265	COG1280	lysine exporter protein (LysE YggA)
A4R38_RS02275	COG1280	lysine exporter protein (LysE YggA)
A4R38_RS02280	COG0514	ATP-dependent DNA helicase (RecQ)
A4R38_RS02285	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A4R38_RS02290	COG2050	protein possibly involved in aromatic compounds catabolism
A4R38_RS02295	COG2962	Rard protein
A4R38_RS02310	COG0598	Magnesium transport protein CorA
A4R38_RS02320	COG3698	Phosphodiester glycosidase
A4R38_RS02325	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
A4R38_RS02330	COG0210	DNA helicase
A4R38_RS02335	COG1011	Hydrolase
A4R38_RS02345	COG3159	Protein conserved in bacteria
A4R38_RS02355	COG5567	small periplasmic lipoprotein
A4R38_RS02365	COG3072	Adenylate cyclase
A4R38_RS02375	COG1587	Uroporphyrinogen-III synthase
A4R38_RS02380	COG2959	enzyme of heme biosynthesis
A4R38_RS02385	COG3071	HemY protein
A4R38_RS02395	COG3119	arylsulfatase activity
A4R38_RS02400	COG0641	radical SAM
A4R38_RS02425	COG1113	amino acid transport
A4R38_RS02445	COG2244	polysaccharide biosynthetic process
A4R38_RS02450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R38_RS02455	COG0456	acetyltransferase
A4R38_RS02460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4R38_RS02465	COG1088	dTDP-glucose 4,6-dehydratase activity
A4R38_RS02470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4R38_RS02475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4R38_RS02480	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4R38_RS02485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4R38_RS02495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4R38_RS02505	COG3118	belongs to the thioredoxin family
A4R38_RS02520	COG0210	DNA helicase
A4R38_RS02525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R38_RS02535	COG0583	DNA-binding transcription factor activity
A4R38_RS02540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R38_RS02550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R38_RS02555	COG3978	acetolactate synthase activity
A4R38_RS02570	COG0606	chelatase, subunit chli
A4R38_RS02575	COG3085	chromosome segregation
A4R38_RS02615	COG2186	Transcriptional regulator
A4R38_RS02620	COG0477	Major facilitator Superfamily
A4R38_RS02625	COG1609	Transcriptional regulator
A4R38_RS02630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS02635	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS02640	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS02645	COG1129	ABC transporter
A4R38_RS02650	COG1869	D-ribose catabolic process
A4R38_RS02675	COG1522	sequence-specific DNA binding
A4R38_RS02680	COG0716	FMN binding
A4R38_RS02695	COG3312	ion transport
A4R38_RS02750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4R38_RS02755	COG0573	inorganic phosphate transmembrane transporter activity
A4R38_RS02760	COG0581	inorganic phosphate transmembrane transporter activity
A4R38_RS02765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4R38_RS02770	COG0704	Plays a role in the regulation of phosphate uptake
A4R38_RS02775	COG3711	transcriptional antiterminator
A4R38_RS02780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS02780	COG1263	PTS System
A4R38_RS02780	COG2190	(PTS) system
A4R38_RS02785	COG2723	6-phospho-beta-galactosidase activity
A4R38_RS02790	COG4580	involved in the transport of maltose and maltodextrins
A4R38_RS02795	COG2382	esterase
A4R38_RS02800	COG0363	glucosamine-6-phosphate deaminase activity
A4R38_RS02805	COG3196	Protein conserved in bacteria
A4R38_RS02815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS02820	COG2252	PERMEase
A4R38_RS02825	COG0431	NADPH-dependent FMN reductase
A4R38_RS02830	COG2091	lysine biosynthetic process via aminoadipic acid
A4R38_RS02835	COG0583	DNA-binding transcription factor activity
A4R38_RS02845	COG0814	amino acid
A4R38_RS02890	COG0592	DNA-directed DNA polymerase activity
A4R38_RS02900	COG0187	DNA topoisomerase II activity
A4R38_RS02910	COG3753	Protein conserved in bacteria
A4R38_RS02915	COG0561	phosphatase activity
A4R38_RS02925	COG2186	Transcriptional regulator
A4R38_RS02930	COG3734	2-keto-3-deoxy-galactonokinase
A4R38_RS02935	COG0800	Aldolase
A4R38_RS02945	COG2271	Major facilitator Superfamily
A4R38_RS02955	COG0823	Involved in the tonB-independent uptake of proteins
A4R38_RS02960	COG5645	(Lipo)protein
A4R38_RS02980	COG2207	Transcriptional regulator
A4R38_RS02985	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R38_RS02990	COG3119	arylsulfatase activity
A4R38_RS02995	COG2149	membrane
A4R38_RS03005	COG0641	radical SAM
A4R38_RS03010	COG2814	Major facilitator Superfamily
A4R38_RS03020	COG0028	Belongs to the TPP enzyme family
A4R38_RS03025	COG0440	acetolactate synthase activity
A4R38_RS03040	COG2197	response regulator
A4R38_RS03045	COG3851	Histidine kinase
A4R38_RS03050	COG2271	Major facilitator Superfamily
A4R38_RS03055	COG2271	Major facilitator Superfamily
A4R38_RS03065	COG2252	PERMEase
A4R38_RS03105	COG1464	Belongs to the NlpA lipoprotein family
A4R38_RS03110	COG0697	spore germination
A4R38_RS03155	COG2003	Belongs to the UPF0758 family
A4R38_RS03180	COG2020	methyltransferase activity
A4R38_RS03185	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS03195	COG4983	Phage plasmid primase, P4 family domain protein
A4R38_RS03245	COG4584	PFAM Integrase catalytic
A4R38_RS03250	COG1484	DNA-dependent DNA replication
A4R38_RS03305	COG3344	reverse transcriptase
A4R38_RS03330	COG0456	acetyltransferase
A4R38_RS03335	COG3039	Transposase
A4R38_RS03340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4R38_RS03360	COG2271	Major facilitator Superfamily
A4R38_RS03365	COG1609	Transcriptional regulator
A4R38_RS03375	COG0582	viral genome integration into host DNA
A4R38_RS03385	COG2211	Major facilitator Superfamily
A4R38_RS03390	COG1501	Belongs to the glycosyl hydrolase 31 family
A4R38_RS03395	COG3711	transcriptional antiterminator
A4R38_RS03400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS03400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS03425	COG1940	carbohydrate kinase activity
A4R38_RS03435	COG2982	Protein involved in outer membrane biogenesis
A4R38_RS03440	COG2233	PERMEase
A4R38_RS03445	COG0786	glutamate:sodium symporter activity
A4R38_RS03450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4R38_RS03455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R38_RS03460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R38_RS03470	COG0194	GDP metabolic process
A4R38_RS03475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4R38_RS03480	COG2860	membrane
A4R38_RS03485	COG1561	YicC-like family, N-terminal region
A4R38_RS03510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4R38_RS03540	COG1519	Transferase
A4R38_RS03545	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03550	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS03555	COG0515	serine threonine protein kinase
A4R38_RS03560	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS03560	COG4641	Protein conserved in bacteria
A4R38_RS03565	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS03570	COG1442	glycosyl transferase family 8
A4R38_RS03575	COG1442	glycosyl transferase family 8
A4R38_RS03580	COG3642	lipopolysaccharide core region biosynthetic process
A4R38_RS03590	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03595	COG3307	-O-antigen
A4R38_RS03600	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03605	COG0859	PFAM glycosyl transferase family 9
A4R38_RS03615	COG0156	8-amino-7-oxononanoate synthase activity
A4R38_RS03625	COG1216	Glycosyl transferase, family 2
A4R38_RS03630	COG2861	carbohydrate metabolic process
A4R38_RS03635	COG4942	peptidase
A4R38_RS03645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4R38_RS03650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4R38_RS03665	COG1045	serine acetyltransferase
A4R38_RS03670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4R38_RS03680	COG2186	Transcriptional regulator
A4R38_RS03685	COG1620	l-lactate permease
A4R38_RS03690	COG5295	Hep Hag repeat protein
A4R38_RS03710	COG3722	fumarate hydratase activity
A4R38_RS03720	COG2213	PTS system mannitol-specific
A4R38_RS03720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS03730	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS03735	COG0625	glutathione transferase activity
A4R38_RS03745	COG3276	selenocysteine insertion sequence binding
A4R38_RS03750	COG1454	alcohol dehydrogenase
A4R38_RS03760	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS03770	COG2211	Major facilitator Superfamily
A4R38_RS03780	COG0235	Class ii aldolase
A4R38_RS03785	COG3623	hexulose-6-phosphate isomerase
A4R38_RS03790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4R38_RS03795	COG1070	Carbohydrate kinase
A4R38_RS03800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4R38_RS03805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4R38_RS03810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4R38_RS03820	COG2731	YhcH YjgK YiaL family protein
A4R38_RS03830	COG1414	Transcriptional regulator
A4R38_RS03835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS03840	COG3977	Valine--pyruvate aminotransferase
A4R38_RS03845	COG0366	Alpha amylase catalytic
A4R38_RS03850	COG2992	FlgJ-related protein
A4R38_RS03855	COG2207	Transcriptional regulator
A4R38_RS03855	COG1609	Transcriptional regulator
A4R38_RS03860	COG4214	carbohydrate transport
A4R38_RS03870	COG4213	ABC transporter substrate-binding protein
A4R38_RS03880	COG1070	Carbohydrate kinase
A4R38_RS03885	COG4682	membrane
A4R38_RS03890	COG4682	membrane
A4R38_RS03895	COG3274	enterobacterial common antigen metabolic process
A4R38_RS03915	COG2963	transposase activity
A4R38_RS03920	COG2801	Transposase and inactivated derivatives
A4R38_RS03930	COG1278	Cold shock
A4R38_RS03935	COG2944	sequence-specific DNA binding
A4R38_RS03950	COG2885	chlorophyll binding
A4R38_RS03955	COG0243	molybdopterin cofactor binding
A4R38_RS03960	COG0456	acetyltransferase
A4R38_RS03965	COG2818	Glycosylase
A4R38_RS03970	COG5571	outer membrane autotransporter
A4R38_RS03975	COG2223	nitrite transmembrane transporter activity
A4R38_RS03980	COG2194	sulfuric ester hydrolase activity
A4R38_RS03995	COG0747	negative chemotaxis
A4R38_RS04005	COG0601	transmembrane transport
A4R38_RS04010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS04015	COG0444	Belongs to the ABC transporter superfamily
A4R38_RS04020	COG4608	Belongs to the ABC transporter superfamily
A4R38_RS04030	COG3550	peptidyl-serine autophosphorylation
A4R38_RS04035	COG3550	peptidyl-serine autophosphorylation
A4R38_RS04040	COG0814	amino acid
A4R38_RS04090	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS04095	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS04100	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A4R38_RS04105	COG3118	belongs to the thioredoxin family
A4R38_RS04105	COG0457	Tetratricopeptide repeat
A4R38_RS04110	COG2200	EAL domain
A4R38_RS04110	COG2199	diguanylate cyclase activity
A4R38_RS04120	COG0612	Peptidase, M16
A4R38_RS04125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS04135	COG2200	EAL domain
A4R38_RS04140	COG2982	Protein involved in outer membrane biogenesis
A4R38_RS04145	COG0477	Major facilitator Superfamily
A4R38_RS04150	COG1295	ribonuclease BN
A4R38_RS04155	COG0583	DNA-binding transcription factor activity
A4R38_RS04160	COG2197	response regulator
A4R38_RS04170	COG1858	cytochrome C peroxidase
A4R38_RS04175	COG0076	glutamate decarboxylase activity
A4R38_RS04180	COG2207	Transcriptional regulator
A4R38_RS04185	COG2207	Transcriptional regulator
A4R38_RS04190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS04205	COG2771	luxR family
A4R38_RS04210	COG3247	response to pH
A4R38_RS04225	COG1285	pathogenesis
A4R38_RS04235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS04245	COG3721	Heme iron utilization protein
A4R38_RS04270	COG4771	TonB-dependent receptor
A4R38_RS04275	COG3720	iron ion transport
A4R38_RS04280	COG2197	response regulator
A4R38_RS04285	COG3065	identical protein binding
A4R38_RS04290	COG1393	Belongs to the ArsC family
A4R38_RS04305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS04310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4R38_RS04315	COG0339	signal peptide processing
A4R38_RS04325	COG3104	oligopeptide transport
A4R38_RS04330	COG0589	response to stress
A4R38_RS04340	COG0306	phosphate transporter
A4R38_RS04345	COG2081	HI0933 family
A4R38_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS04360	COG0842	Transport permease protein
A4R38_RS04360	COG1129	ABC transporter
A4R38_RS04365	COG0842	Transport permease protein
A4R38_RS04370	COG0191	fructose-bisphosphate aldolase activity
A4R38_RS04385	COG3775	system Galactitol-specific IIC component
A4R38_RS04390	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS04400	COG2188	Transcriptional regulator
A4R38_RS04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS04425	COG0601	transmembrane transport
A4R38_RS04430	COG0747	negative chemotaxis
A4R38_RS04435	COG2091	lysine biosynthetic process via aminoadipic acid
A4R38_RS04440	COG0628	permease
A4R38_RS04445	COG0477	Major facilitator Superfamily
A4R38_RS04455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4R38_RS04470	COG3714	YhhN family
A4R38_RS04480	COG3776	membrane
A4R38_RS04485	COG0742	ribosomal rna small subunit methyltransferase
A4R38_RS04490	COG0552	protein localization to endoplasmic reticulum
A4R38_RS04495	COG2884	Cell division ATP-binding protein ftsE
A4R38_RS04500	COG2177	Part of the ABC transporter FtsEX involved in
A4R38_RS04505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4R38_RS04510	COG0683	leucine binding
A4R38_RS04525	COG0456	acetyltransferase
A4R38_RS04530	COG0683	leucine binding
A4R38_RS04535	COG0559	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS04540	COG4177	L-phenylalanine transmembrane transporter activity
A4R38_RS04545	COG0411	ABC transporter
A4R38_RS04550	COG0410	ABC transporter
A4R38_RS04580	COG0584	glycerophosphoryl diester phosphodiesterase
A4R38_RS04590	COG0405	Gamma-glutamyltransferase
A4R38_RS04595	COG1247	-acetyltransferase
A4R38_RS04605	COG0673	inositol 2-dehydrogenase activity
A4R38_RS04610	COG1741	Belongs to the pirin family
A4R38_RS04615	COG1609	Transcriptional regulator
A4R38_RS04620	COG3265	gluconokinase activity
A4R38_RS04625	COG2610	gluconate transmembrane transporter activity
A4R38_RS04630	COG0514	ATP-dependent DNA helicase (RecQ)
A4R38_RS04640	COG2095	MarC family integral membrane protein
A4R38_RS04645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4R38_RS04670	COG0058	SHG alpha-glucan phosphorylase activity
A4R38_RS04675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4R38_RS04690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4R38_RS04705	COG1349	DNA-binding transcription factor activity
A4R38_RS04710	COG4650	regulator
A4R38_RS04725	COG0058	SHG alpha-glucan phosphorylase activity
A4R38_RS04730	COG1640	4-alpha-glucanotransferase
A4R38_RS04735	COG2610	gluconate transmembrane transporter activity
A4R38_RS04750	COG0596	Alpha beta hydrolase
A4R38_RS04755	COG5464	transposase or invertase
A4R38_RS04765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4R38_RS04770	COG1918	ferrous iron import across plasma membrane
A4R38_RS04775	COG2183	response to ionizing radiation
A4R38_RS04780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R38_RS04805	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4R38_RS04815	COG0675	Transposase, IS605 OrfB family
A4R38_RS04825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4R38_RS04830	COG1011	Hydrolase
A4R38_RS04840	COG0494	nUDIX hydrolase
A4R38_RS04845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A4R38_RS04850	COG4972	Pilus assembly protein
A4R38_RS04855	COG3166	PFAM Fimbrial assembly family protein
A4R38_RS04870	COG4796	Type ii and iii secretion system protein
A4R38_RS04885	COG3266	domain, Protein
A4R38_RS04890	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4R38_RS04895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4R38_RS04905	COG0180	Tryptophanyl-tRNA synthetase
A4R38_RS04910	COG2188	Transcriptional regulator
A4R38_RS04920	COG3457	Alanine racemase
A4R38_RS04925	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A4R38_RS04930	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A4R38_RS04945	COG0626	cystathionine gamma-synthase activity
A4R38_RS04960	COG2116	formate transmembrane transporter activity
A4R38_RS04965	COG2146	nitrite reductase [NAD(P)H] activity
A4R38_RS04970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R38_RS04980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R38_RS04990	COG2184	nucleotidyltransferase activity
A4R38_RS04995	COG0512	Glutamine amidotransferase of anthranilate synthase
A4R38_RS05000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R38_RS05005	COG1289	transmembrane transporter activity
A4R38_RS05010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS05020	COG1765	OsmC-like protein
A4R38_RS05025	COG3954	Phosphoribulokinase
A4R38_RS05035	COG0429	hydrolase of the alpha beta-hydrolase fold
A4R38_RS05040	COG0488	(ABC) transporter
A4R38_RS05055	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A4R38_RS05060	COG1047	Peptidyl-prolyl cis-trans
A4R38_RS05070	COG0545	Peptidyl-prolyl cis-trans isomerase
A4R38_RS05075	COG2964	Protein conserved in bacteria
A4R38_RS05115	COG3979	chitinase
A4R38_RS05120	COG2906	2 iron, 2 sulfur cluster binding
A4R38_RS05125	COG2193	ferroxidase activity
A4R38_RS05130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4R38_RS05135	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A4R38_RS05140	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A4R38_RS05145	COG3156	type II secretion system protein K
A4R38_RS05150	COG4795	General secretion pathway protein
A4R38_RS05155	COG2165	general secretion pathway protein
A4R38_RS05160	COG2165	general secretion pathway protein
A4R38_RS05165	COG2165	general secretion pathway protein
A4R38_RS05170	COG1459	type II secretion system
A4R38_RS05175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4R38_RS05180	COG1450	Type ii and iii secretion system protein
A4R38_RS05185	COG3031	protein transport across the cell outer membrane
A4R38_RS05190	COG3409	Peptidoglycan-binding domain 1 protein
A4R38_RS05190	COG3267	Type II secretory pathway component ExeA
A4R38_RS05215	COG0089	rRNA binding
A4R38_RS05305	COG0201	protein transport
A4R38_RS05345	COG0789	Transcriptional regulator
A4R38_RS05350	COG3036	rescue of stalled ribosome
A4R38_RS05360	COG0569	domain protein
A4R38_RS05380	COG0758	DNA mediated transformation
A4R38_RS05390	COG0551	DNA topoisomerase type I activity
A4R38_RS05395	COG0009	L-threonylcarbamoyladenylate synthase
A4R38_RS05410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4R38_RS05450	COG1126	abc transporter atp-binding protein
A4R38_RS05455	COG0765	amino acid transport
A4R38_RS05460	COG4597	amino acid ABC transporter
A4R38_RS05465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS05480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS05485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS05490	COG1309	transcriptional regulator
A4R38_RS05500	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A4R38_RS05510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4R38_RS05520	COG4145	pantothenate transmembrane transporter activity
A4R38_RS05525	COG3924	membrane
A4R38_RS05530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS05535	COG1349	DNA-binding transcription factor activity
A4R38_RS05545	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS05550	COG1129	ABC transporter
A4R38_RS05555	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS05560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS05570	COG0439	Biotin carboxylase
A4R38_RS05575	COG0511	ligase activity, forming carbon-carbon bonds
A4R38_RS05590	COG0604	alcohol dehydrogenase
A4R38_RS05595	COG2200	EAL domain
A4R38_RS05595	COG2199	diguanylate cyclase activity
A4R38_RS05605	COG1077	Cell shape determining protein MreB Mrl
A4R38_RS05610	COG1792	Involved in formation and maintenance of cell shape
A4R38_RS05615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4R38_RS05625	COG1530	ribonuclease E activity
A4R38_RS05630	COG3164	Protein of unknown function
A4R38_RS05635	COG0312	modulator of DNA gyrase
A4R38_RS05640	COG0583	DNA-binding transcription factor activity
A4R38_RS05660	COG2732	(Barnase) inhibitor
A4R38_RS05680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R38_RS05685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R38_RS05690	COG3105	Protein conserved in bacteria
A4R38_RS05695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A4R38_RS05710	COG0625	glutathione transferase activity
A4R38_RS05715	COG2969	positive regulation of protein catabolic process
A4R38_RS05730	COG2814	Major facilitator Superfamily
A4R38_RS05740	COG1940	carbohydrate kinase activity
A4R38_RS05745	COG2731	YhcH YjgK YiaL family protein
A4R38_RS05750	COG0493	'glutamate synthase
A4R38_RS05755	COG0069	glutamate synthase activity
A4R38_RS05755	COG0067	glutamate synthase
A4R38_RS05755	COG0070	glutamate synthase
A4R38_RS05760	COG1242	4 iron, 4 sulfur cluster binding
A4R38_RS05765	COG5002	protein histidine kinase activity
A4R38_RS05765	COG2198	Histidine kinase
A4R38_RS05765	COG0784	Response regulator, receiver
A4R38_RS05770	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A4R38_RS05780	COG0515	serine threonine protein kinase
A4R38_RS05785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS05800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4R38_RS05805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A4R38_RS05810	COG1137	ATPase activity
A4R38_RS05815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4R38_RS05820	COG3117	lipopolysaccharide transmembrane transporter activity
A4R38_RS05825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4R38_RS05830	COG0517	IMP dehydrogenase activity
A4R38_RS05830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4R38_RS05835	COG0530	calcium, potassium:sodium antiporter activity
A4R38_RS05840	COG1127	ABC transporter
A4R38_RS05845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R38_RS05850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4R38_RS05855	COG2854	intermembrane phospholipid transfer
A4R38_RS05860	COG3113	response to antibiotic
A4R38_RS05865	COG5007	Belongs to the BolA IbaG family
A4R38_RS05875	COG3423	Transcriptional regulator
A4R38_RS05880	COG0142	geranyltranstransferase activity
A4R38_RS05895	COG0697	spore germination
A4R38_RS05905	COG2027	D-alanyl-D-alanine carboxypeptidase
A4R38_RS05910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R38_RS05915	COG1534	Rna-binding protein
A4R38_RS05925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R38_RS05930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4R38_RS05940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4R38_RS05955	COG2194	sulfuric ester hydrolase activity
A4R38_RS05975	COG0195	Participates in both transcription termination and antitermination
A4R38_RS06010	COG0513	Belongs to the DEAD box helicase family
A4R38_RS06020	COG0814	amino acid
A4R38_RS06025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R38_RS06030	COG0826	peptidase U32
A4R38_RS06035	COG0826	peptidase U32
A4R38_RS06040	COG3154	lipid carrier protein
A4R38_RS06045	COG3153	acetyltransferase
A4R38_RS06060	COG0693	protein deglycase activity
A4R38_RS06065	COG0702	epimerase
A4R38_RS06070	COG0701	Predicted permease
A4R38_RS06075	COG2823	Periplasmic or secreted lipoprotein
A4R38_RS06095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4R38_RS06100	COG0363	glucosamine-6-phosphate deaminase activity
A4R38_RS06105	COG3716	PTS system mannose fructose sorbose family IID component
A4R38_RS06110	COG3715	PTS system
A4R38_RS06115	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS06125	COG2222	sugar isomerase
A4R38_RS06130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4R38_RS06135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS06140	COG3716	PTS system mannose fructose sorbose family IID component
A4R38_RS06150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS06160	COG1349	DNA-binding transcription factor activity
A4R38_RS06170	COG2002	toxin-antitoxin pair type II binding
A4R38_RS06175	COG2721	sulfolactate sulfo-lyase activity
A4R38_RS06180	COG2271	Major facilitator Superfamily
A4R38_RS06190	COG2084	Dehydrogenase
A4R38_RS06195	COG1929	Belongs to the glycerate kinase type-1 family
A4R38_RS06210	COG0583	DNA-binding transcription factor activity
A4R38_RS06215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R38_RS06225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4R38_RS06230	COG1882	Formate acetyltransferase
A4R38_RS06235	COG0251	oxidation-reduction process
A4R38_RS06240	COG1760	l-serine dehydratase
A4R38_RS06245	COG0814	amino acid
A4R38_RS06260	COG1741	Belongs to the pirin family
A4R38_RS06265	COG0583	DNA-binding transcription factor activity
A4R38_RS06270	COG3152	Membrane
A4R38_RS06280	COG0435	Glutathione S-transferase
A4R38_RS06285	COG2259	Doxx family
A4R38_RS06295	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A4R38_RS06300	COG4575	ribosome binding
A4R38_RS06305	COG1422	Protein of unknown function (DUF1090)
A4R38_RS06315	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS06320	COG2186	Transcriptional regulator
A4R38_RS06325	COG2271	Major facilitator Superfamily
A4R38_RS06335	COG2721	sulfolactate sulfo-lyase activity
A4R38_RS06350	COG0861	Integral membrane protein TerC family
A4R38_RS06355	COG0673	inositol 2-dehydrogenase activity
A4R38_RS06360	COG2949	membrane
A4R38_RS06365	COG1451	nucleotide metabolic process
A4R38_RS06380	COG4680	protein conserved in bacteria
A4R38_RS06385	COG5499	transcription regulator containing HTH domain
A4R38_RS06390	COG1902	pentaerythritol trinitrate reductase activity
A4R38_RS06390	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4R38_RS06395	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A4R38_RS06395	COG3408	Glycogen debranching enzyme
A4R38_RS06405	COG0531	amino acid
A4R38_RS06410	COG2731	YhcH YjgK YiaL family protein
A4R38_RS06415	COG3250	beta-galactosidase activity
A4R38_RS06420	COG1609	Transcriptional regulator
A4R38_RS06425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4R38_RS06435	COG0840	transmembrane signaling receptor activity
A4R38_RS06440	COG1695	Transcriptional regulator
A4R38_RS06445	COG2375	cellular response to nickel ion
A4R38_RS06460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4R38_RS06465	COG0358	DNA primase activity
A4R38_RS06470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4R38_RS06480	COG0471	metal ion transport
A4R38_RS06485	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS06490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS06505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4R38_RS06520	COG4991	sh3 domain protein
A4R38_RS06530	COG3025	triphosphatase activity
A4R38_RS06550	COG2268	Band 7 protein
A4R38_RS06555	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4R38_RS06575	COG3539	Fimbrial protein
A4R38_RS06580	COG3121	Chaperone
A4R38_RS06585	COG3188	usher protein
A4R38_RS06590	COG3539	Fimbrial protein
A4R38_RS06605	COG3384	dioxygenase
A4R38_RS06615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4R38_RS06625	COG0754	glutathionylspermidine amidase activity
A4R38_RS06640	COG1538	Outer membrane efflux protein
A4R38_RS06645	COG0494	nUDIX hydrolase
A4R38_RS06650	COG3151	Protein conserved in bacteria
A4R38_RS06655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4R38_RS06660	COG3150	esterase
A4R38_RS06665	COG0187	DNA topoisomerase II activity
A4R38_RS06670	COG4774	siderophore transport
A4R38_RS06675	COG1120	ATPase activity
A4R38_RS06680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS06685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS06695	COG1737	Transcriptional regulator
A4R38_RS06700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4R38_RS06705	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4R38_RS06725	COG0642	Histidine kinase
A4R38_RS06730	COG0745	RESPONSE REGULATOR receiver
A4R38_RS06735	COG3111	PFAM Bacterial OB fold (BOF) protein
A4R38_RS06740	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4R38_RS06745	COG4166	transmembrane transport
A4R38_RS06750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4R38_RS06755	COG0204	Acyl-transferase
A4R38_RS06780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS06785	COG1063	alcohol dehydrogenase
A4R38_RS06790	COG0246	Mannitol dehydrogenase
A4R38_RS06795	COG2186	Transcriptional regulator
A4R38_RS06800	COG1032	radical SAM domain protein
A4R38_RS06805	COG4238	major outer membrane lipoprotein
A4R38_RS06815	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS06820	COG1979	alcohol dehydrogenase
A4R38_RS06830	COG2207	Transcriptional regulator
A4R38_RS06835	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS06840	COG0626	cystathionine gamma-synthase activity
A4R38_RS06850	COG0811	peptide transport
A4R38_RS06855	COG0848	biopolymer transport protein
A4R38_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS06870	COG0667	Aldo Keto reductase
A4R38_RS06890	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A4R38_RS06895	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS06900	COG5557	Pfam Polysulphide reductase, NrfD
A4R38_RS06905	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A4R38_RS06910	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4R38_RS06915	COG1773	rubredoxin
A4R38_RS06925	COG0298	carbon dioxide binding
A4R38_RS06930	COG0625	glutathione transferase activity
A4R38_RS06935	COG0754	glutathionylspermidine amidase activity
A4R38_RS06940	COG0306	phosphate transporter
A4R38_RS06945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R38_RS06950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R38_RS06955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R38_RS06960	COG2244	polysaccharide biosynthetic process
A4R38_RS06970	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4R38_RS06975	COG0795	lipopolysaccharide-transporting ATPase activity
A4R38_RS06985	COG0156	8-amino-7-oxononanoate synthase activity
A4R38_RS06990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R38_RS07000	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS07005	COG0456	acetyltransferase
A4R38_RS07010	COG2186	Transcriptional regulator
A4R38_RS07015	COG0277	FAD linked oxidase domain protein
A4R38_RS07020	COG0277	FAD linked oxidase domain protein
A4R38_RS07025	COG0247	lactate metabolic process
A4R38_RS07030	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A4R38_RS07035	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4R38_RS07040	COG1620	l-lactate permease
A4R38_RS07050	COG3064	Membrane
A4R38_RS07055	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4R38_RS07075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4R38_RS07080	COG1459	type II secretion system
A4R38_RS07085	COG2165	general secretion pathway protein
A4R38_RS07115	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A4R38_RS07175	COG1484	DNA-dependent DNA replication
A4R38_RS07180	COG4584	PFAM Integrase catalytic
A4R38_RS07235	COG2003	Belongs to the UPF0758 family
A4R38_RS07260	COG2020	methyltransferase activity
A4R38_RS07265	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS07275	COG4983	Phage plasmid primase, P4 family domain protein
A4R38_RS07315	COG4372	Transposase
A4R38_RS07320	COG4372	Transposase
A4R38_RS07325	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS07345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS07350	COG1940	carbohydrate kinase activity
A4R38_RS07355	COG2814	Major facilitator Superfamily
A4R38_RS07365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4R38_RS07370	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A4R38_RS07375	COG0657	acetylesterase activity
A4R38_RS07375	COG2755	lipolytic protein G-D-S-L family
A4R38_RS07410	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS07415	COG4372	Transposase
A4R38_RS07425	COG4771	TonB-dependent receptor
A4R38_RS07490	COG2826	transposase and inactivated derivatives, IS30 family
A4R38_RS07500	COG2801	Transposase and inactivated derivatives
A4R38_RS07505	COG3344	reverse transcriptase
A4R38_RS07515	COG2826	transposase and inactivated derivatives, IS30 family
A4R38_RS07525	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS07615	COG3344	reverse transcriptase
A4R38_RS07670	COG0582	viral genome integration into host DNA
A4R38_RS07680	COG1811	Na channel or pump
A4R38_RS07685	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS07690	COG2211	Major facilitator Superfamily
A4R38_RS07705	COG1194	a g-specific adenine glycosylase
A4R38_RS07715	COG3171	Protein conserved in bacteria
A4R38_RS07730	COG0252	asparaginase activity
A4R38_RS07740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4R38_RS07755	COG0762	integral membrane protein
A4R38_RS07760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4R38_RS07765	COG2805	Type II/IV secretion system protein
A4R38_RS07780	COG0189	ligase activity
A4R38_RS07785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4R38_RS07790	COG2356	endonuclease I
A4R38_RS07800	COG2814	Major facilitator Superfamily
A4R38_RS07825	COG1166	arginine decarboxylase activity
A4R38_RS07840	COG0501	Belongs to the peptidase M48B family
A4R38_RS07845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4R38_RS07850	COG0330	HflC and HflK could
A4R38_RS07855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS07860	COG2213	PTS system mannitol-specific
A4R38_RS07865	COG1063	alcohol dehydrogenase
A4R38_RS07870	COG1494	fructose-1,6-bisphosphatase
A4R38_RS07880	COG1072	(Pantothenic acid kinase))
A4R38_RS07885	COG1122	ATPase activity
A4R38_RS07920	COG0191	fructose-bisphosphate aldolase activity
A4R38_RS07925	COG0668	transmembrane transport
A4R38_RS07930	COG1279	arginine transmembrane transporter activity
A4R38_RS07935	COG2968	Membrane
A4R38_RS07945	COG0583	DNA-binding transcription factor activity
A4R38_RS07950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R38_RS07950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R38_RS07970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R38_RS07975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4R38_RS07995	COG0006	proline dipeptidase activity
A4R38_RS08000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R38_RS08005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R38_RS08025	COG2723	6-phospho-beta-galactosidase activity
A4R38_RS08035	COG1272	protein, Hemolysin III
A4R38_RS08045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4R38_RS08055	COG0716	FMN binding
A4R38_RS08060	COG4974	Belongs to the 'phage' integrase family
A4R38_RS08065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R38_RS08070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4R38_RS08080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4R38_RS08095	COG2233	PERMEase
A4R38_RS08105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS08105	COG0493	'glutamate synthase
A4R38_RS08110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS08115	COG2252	PERMEase
A4R38_RS08120	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS08125	COG2233	PERMEase
A4R38_RS08130	COG2080	2 iron, 2 sulfur cluster binding
A4R38_RS08130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R38_RS08135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R38_RS08140	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS08145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS08145	COG0493	'glutamate synthase
A4R38_RS08150	COG2068	MobA-Related Protein
A4R38_RS08155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4R38_RS08160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4R38_RS08160	COG3608	succinylglutamate desuccinylase aspartoacylase
A4R38_RS08165	COG0549	Belongs to the carbamate kinase family
A4R38_RS08175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R38_RS08180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R38_RS08185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4R38_RS08190	COG3829	transcription factor binding
A4R38_RS08195	COG2080	2 iron, 2 sulfur cluster binding
A4R38_RS08200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R38_RS08205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R38_RS08210	COG4942	peptidase
A4R38_RS08220	COG0814	amino acid
A4R38_RS08225	COG0183	Belongs to the thiolase family
A4R38_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS08240	COG2814	Major facilitator Superfamily
A4R38_RS08245	COG1794	racemase activity, acting on amino acids and derivatives
A4R38_RS08250	COG0583	DNA-binding transcription factor activity
A4R38_RS08260	COG1609	Transcriptional regulator
A4R38_RS08275	COG0667	Aldo Keto reductase
A4R38_RS08285	COG0861	Integral membrane protein TerC family
A4R38_RS08310	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A4R38_RS08325	COG2165	general secretion pathway protein
A4R38_RS08330	COG4795	General secretion pathway protein
A4R38_RS08340	COG4967	type IV pilus modification protein PilV
A4R38_RS08345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4R38_RS08350	COG1025	Belongs to the peptidase M16 family
A4R38_RS08355	COG1074	ATP-dependent DNA helicase activity
A4R38_RS08360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4R38_RS08365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4R38_RS08365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4R38_RS08370	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS08375	COG3711	transcriptional antiterminator
A4R38_RS08380	COG1263	PTS System
A4R38_RS08380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS08385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4R38_RS08400	COG4584	PFAM Integrase catalytic
A4R38_RS08405	COG1484	DNA-dependent DNA replication
A4R38_RS08520	COG2885	chlorophyll binding
A4R38_RS08560	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4R38_RS08565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4R38_RS08570	COG2166	iron-sulfur cluster assembly
A4R38_RS08575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R38_RS08585	COG0583	DNA-binding transcription factor activity
A4R38_RS08590	COG2363	Small membrane protein
A4R38_RS08600	COG1349	DNA-binding transcription factor activity
A4R38_RS08610	COG1070	Carbohydrate kinase
A4R38_RS08620	COG0738	Major facilitator superfamily
A4R38_RS08625	COG0235	Class ii aldolase
A4R38_RS08630	COG1454	alcohol dehydrogenase
A4R38_RS08640	COG1760	l-serine dehydratase
A4R38_RS08645	COG0814	amino acid
A4R38_RS08650	COG1611	Belongs to the LOG family
A4R38_RS08670	COG3098	single-species biofilm formation
A4R38_RS08675	COG0564	pseudouridine synthase activity
A4R38_RS08680	COG0716	FMN binding
A4R38_RS08685	COG2271	Major facilitator Superfamily
A4R38_RS08690	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS08695	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS08700	COG3850	Histidine kinase
A4R38_RS08700	COG3437	response regulator, receiver
A4R38_RS08700	COG4999	Histidine kinase
A4R38_RS08700	COG2205	protein histidine kinase activity
A4R38_RS08710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R38_RS08715	COG3956	TIGRFAM MazG family protein
A4R38_RS08730	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4R38_RS08740	COG0602	queuosine metabolic process
A4R38_RS08770	COG1070	Carbohydrate kinase
A4R38_RS08775	COG2223	nitrite transmembrane transporter activity
A4R38_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS08785	COG0277	FAD linked oxidase domain protein
A4R38_RS08790	COG0477	Major facilitator Superfamily
A4R38_RS08795	COG2086	electron transfer activity
A4R38_RS08800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4R38_RS08805	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A4R38_RS08810	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4R38_RS08815	COG0644	oxidoreductase
A4R38_RS08820	COG0720	synthase
A4R38_RS08845	COG2234	aminopeptidase activity
A4R38_RS08885	COG0585	pseudouridine synthase activity
A4R38_RS08900	COG1388	LysM domain
A4R38_RS08900	COG4942	peptidase
A4R38_RS08905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4R38_RS08920	COG2610	gluconate transmembrane transporter activity
A4R38_RS08925	COG3622	Belongs to the hyi family
A4R38_RS08930	COG0235	Class ii aldolase
A4R38_RS08935	COG3395	kinase activity
A4R38_RS08940	COG2084	Dehydrogenase
A4R38_RS08945	COG1349	DNA-binding transcription factor activity
A4R38_RS08950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R38_RS08955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4R38_RS08970	COG3604	Transcriptional regulator
A4R38_RS08975	COG0309	Hydrogenase expression formation protein (HypE)
A4R38_RS08980	COG0409	Hydrogenase expression formation protein
A4R38_RS08985	COG0298	carbon dioxide binding
A4R38_RS08990	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4R38_RS08995	COG0375	protein maturation
A4R38_RS09010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS09015	COG0651	ATP synthesis coupled electron transport
A4R38_RS09020	COG0650	Formate hydrogenlyase subunit 4
A4R38_RS09025	COG3261	NADH dehydrogenase
A4R38_RS09025	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A4R38_RS09030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R38_RS09035	COG3260	NADH ubiquinone oxidoreductase 20
A4R38_RS09045	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4R38_RS09050	COG5499	transcription regulator containing HTH domain
A4R38_RS09060	COG2723	6-phospho-beta-galactosidase activity
A4R38_RS09065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS09070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4R38_RS09090	COG0517	IMP dehydrogenase activity
A4R38_RS09090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4R38_RS09095	COG1349	DNA-binding transcription factor activity
A4R38_RS09100	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS09115	COG3732	PTS system glucitol sorbitol-specific
A4R38_RS09120	COG3730	PTS system glucitol sorbitol-specific
A4R38_RS09125	COG2951	lytic endotransglycosylase activity
A4R38_RS09135	COG1546	Belongs to the CinA family
A4R38_RS09160	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4R38_RS09190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS09195	COG1238	metal cluster binding
A4R38_RS09220	COG2814	Major facilitator Superfamily
A4R38_RS09225	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS09230	COG1846	Transcriptional regulator
A4R38_RS09240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4R38_RS09245	COG2814	Major facilitator Superfamily
A4R38_RS09250	COG2113	Glycine betaine
A4R38_RS09255	COG4176	ABC-type proline glycine betaine transport system permease component
A4R38_RS09260	COG4175	Glycine betaine
A4R38_RS09265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS09270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS09280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4R38_RS09285	COG4575	ribosome binding
A4R38_RS09300	COG2916	Histone family protein nucleoid-structuring protein H-NS
A4R38_RS09305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4R38_RS09310	COG0640	Transcriptional regulator
A4R38_RS09315	COG0401	homolog of Blt101
A4R38_RS09320	COG1652	LysM domain
A4R38_RS09325	COG1802	Transcriptional regulator
A4R38_RS09330	COG1113	amino acid transport
A4R38_RS09335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4R38_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS09345	COG0579	oxidoreductase
A4R38_RS09365	COG2867	negative regulation of translational initiation
A4R38_RS09375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS09380	COG0497	DNA recombination
A4R38_RS09395	COG4536	flavin adenine dinucleotide binding
A4R38_RS09400	COG4137	Cytochrome C assembly protein
A4R38_RS09405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4R38_RS09430	COG2885	chlorophyll binding
A4R38_RS09435	COG2199	diguanylate cyclase activity
A4R38_RS09450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R38_RS09455	COG0287	Prephenate dehydrogenase
A4R38_RS09455	COG1605	Chorismate mutase
A4R38_RS09460	COG0077	Prephenate dehydratase
A4R38_RS09460	COG1605	Chorismate mutase
A4R38_RS09465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4R38_RS09475	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS09480	COG0564	pseudouridine synthase activity
A4R38_RS09490	COG0542	response to heat
A4R38_RS09515	COG0477	Major facilitator Superfamily
A4R38_RS09520	COG5544	Lipoprotein
A4R38_RS09525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS09530	COG1042	CoA-binding domain protein
A4R38_RS09530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS09530	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R38_RS09535	COG3148	PFAM DTW domain containing protein
A4R38_RS09540	COG3118	belongs to the thioredoxin family
A4R38_RS09550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R38_RS09570	COG0583	DNA-binding transcription factor activity
A4R38_RS09575	COG0513	Belongs to the DEAD box helicase family
A4R38_RS09585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4R38_RS09595	COG1595	DNA-templated transcription, initiation
A4R38_RS09600	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A4R38_RS09605	COG3026	antisigma factor binding
A4R38_RS09610	COG3086	response to oxidative stress
A4R38_RS09620	COG0681	Belongs to the peptidase S26 family
A4R38_RS09640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4R38_RS09660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS09665	COG1737	Transcriptional regulator
A4R38_RS09670	COG0560	Phosphoserine phosphatase
A4R38_RS09675	COG0590	tRNA wobble adenosine to inosine editing
A4R38_RS09690	COG2205	protein histidine kinase activity
A4R38_RS09695	COG3170	Tfp pilus assembly protein FimV
A4R38_RS09700	COG2204	response regulator
A4R38_RS09705	COG0347	Belongs to the P(II) protein family
A4R38_RS09710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R38_RS09710	COG1017	nitric oxide dioxygenase activity
A4R38_RS09720	COG1940	carbohydrate kinase activity
A4R38_RS09725	COG0457	Tetratricopeptide repeat
A4R38_RS09730	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS09735	COG1129	ABC transporter
A4R38_RS09740	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS09745	COG1063	alcohol dehydrogenase
A4R38_RS09750	COG2017	converts alpha-aldose to the beta-anomer
A4R38_RS09755	COG2259	Doxx family
A4R38_RS09760	COG2814	Major facilitator Superfamily
A4R38_RS09765	COG3711	transcriptional antiterminator
A4R38_RS09770	COG1073	alpha beta
A4R38_RS09775	COG0483	inositol monophosphate 1-phosphatase activity
A4R38_RS09795	COG0822	iron-sulfur transferase activity
A4R38_RS09815	COG0633	Ferredoxin
A4R38_RS09820	COG2975	iron-sulfur cluster assembly
A4R38_RS09835	COG2897	thiosulfate sulfurtransferase activity
A4R38_RS09840	COG2373	Large extracellular alpha-helical protein
A4R38_RS09845	COG4953	penicillin-binding protein 1C
A4R38_RS09875	COG2976	Protein conserved in bacteria
A4R38_RS09890	COG1645	bacterial-type flagellum-dependent swarming motility
A4R38_RS09915	COG0517	IMP dehydrogenase activity
A4R38_RS09915	COG0516	GMP reductase activity
A4R38_RS09930	COG3133	Outer membrane lipoprotein
A4R38_RS09945	COG2200	EAL domain
A4R38_RS09950	COG0248	Ppx GppA phosphatase
A4R38_RS09955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4R38_RS09960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4R38_RS09975	COG2233	PERMEase
A4R38_RS09985	COG1393	Belongs to the ArsC family
A4R38_RS09990	COG4783	chaperone-mediated protein folding
A4R38_RS09995	COG0628	permease
A4R38_RS10000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4R38_RS10005	COG2716	regulation of RNA biosynthetic process
A4R38_RS10015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A4R38_RS10030	COG2321	neutral zinc metallopeptidase
A4R38_RS10040	COG0400	carboxylic ester hydrolase activity
A4R38_RS10055	COG1393	Belongs to the ArsC family
A4R38_RS10065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS10070	COG3850	Histidine kinase
A4R38_RS10075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS10075	COG0493	'glutamate synthase
A4R38_RS10085	COG5342	invasion associated locus B
A4R38_RS10090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4R38_RS10095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R38_RS10100	COG0281	malic enzyme
A4R38_RS10100	COG0280	phosphate acetyltransferase
A4R38_RS10105	COG4810	utilization protein
A4R38_RS10110	COG4917	ethanolamine utilization protein
A4R38_RS10115	COG4766	ethanolamine catabolic process
A4R38_RS10120	COG4812	Cobalamin adenosyltransferase
A4R38_RS10125	COG0280	phosphate acetyltransferase
A4R38_RS10130	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4R38_RS10135	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A4R38_RS10140	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS10145	COG4820	ethanolamine utilization protein (EutJ)
A4R38_RS10150	COG1454	alcohol dehydrogenase
A4R38_RS10155	COG3192	ethanolamine utilization protein
A4R38_RS10160	COG4819	ethanolamine utilization protein
A4R38_RS10165	COG4303	Ethanolamine ammonia lyase large subunit
A4R38_RS10175	COG4816	utilization protein
A4R38_RS10180	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4R38_RS10185	COG2207	Transcriptional regulator
A4R38_RS10195	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS10215	COG2837	iron assimilation
A4R38_RS10220	COG1263	PTS System
A4R38_RS10220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS10235	COG4150	thiosulfate binding
A4R38_RS10240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4R38_RS10245	COG4208	sulfate ABC transporter
A4R38_RS10250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4R38_RS10255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R38_RS10270	COG2190	(PTS) system
A4R38_RS10275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS10280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS10285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R38_RS10305	COG3530	Putative quorum-sensing-regulated virulence factor
A4R38_RS10310	COG0385	Bile acid
A4R38_RS10315	COG0583	DNA-binding transcription factor activity
A4R38_RS10325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4R38_RS10330	COG2211	Major facilitator Superfamily
A4R38_RS10340	COG0583	DNA-binding transcription factor activity
A4R38_RS10365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4R38_RS10370	COG3415	Transposase
A4R38_RS10375	COG3415	Transposase
A4R38_RS10390	COG2199	diguanylate cyclase activity
A4R38_RS10390	COG2200	EAL domain
A4R38_RS10395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4R38_RS10425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS10430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS10435	COG0006	proline dipeptidase activity
A4R38_RS10440	COG1363	Peptidase, m42
A4R38_RS10445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS10445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS10445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS10450	COG2207	Transcriptional regulator
A4R38_RS10455	COG3279	Response regulator of the LytR AlgR family
A4R38_RS10460	COG3275	phosphorelay sensor kinase activity
A4R38_RS10465	COG0436	Aminotransferase
A4R38_RS10470	COG1560	Kdo2-lipid A biosynthetic process
A4R38_RS10500	COG0028	Belongs to the TPP enzyme family
A4R38_RS10505	COG0679	Auxin Efflux Carrier
A4R38_RS10510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R38_RS10515	COG0784	Response regulator, receiver
A4R38_RS10515	COG2198	Histidine kinase
A4R38_RS10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS10515	COG2205	protein histidine kinase activity
A4R38_RS10520	COG2197	response regulator
A4R38_RS10525	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS10530	COG0477	Major facilitator Superfamily
A4R38_RS10540	COG2610	gluconate transmembrane transporter activity
A4R38_RS10545	COG0583	DNA-binding transcription factor activity
A4R38_RS10555	COG2116	formate transmembrane transporter activity
A4R38_RS10565	COG2067	long-chain fatty acid transport protein
A4R38_RS10570	COG3691	Protein conserved in bacteria
A4R38_RS10585	COG2062	phosphohistidine phosphatase, SixA
A4R38_RS10590	COG3539	Fimbrial protein
A4R38_RS10595	COG3188	usher protein
A4R38_RS10600	COG1662	PFAM IS1 transposase
A4R38_RS10605	COG3188	usher protein
A4R38_RS10610	COG3121	Chaperone
A4R38_RS10615	COG3539	Fimbrial protein
A4R38_RS10620	COG3539	Fimbrial protein
A4R38_RS10625	COG3539	Fimbrial protein
A4R38_RS10655	COG0730	response to heat
A4R38_RS10660	COG3101	peptidyl-lysine hydroxylation
A4R38_RS10675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4R38_RS10680	COG2814	Major facilitator Superfamily
A4R38_RS10695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4R38_RS10705	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS10715	COG0285	dihydrofolate synthase activity
A4R38_RS10720	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A4R38_RS10725	COG1286	toxin biosynthetic process
A4R38_RS10730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4R38_RS10735	COG0163	prenyltransferase activity
A4R38_RS10740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS10745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS10750	COG4215	(ABC) transporter
A4R38_RS10755	COG4160	amino acid transport
A4R38_RS10760	COG4598	ABC transporter
A4R38_RS10765	COG1090	epimerase
A4R38_RS10770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4R38_RS10775	COG0625	glutathione transferase activity
A4R38_RS10780	COG0625	glutathione transferase activity
A4R38_RS10785	COG0622	Phosphoesterase
A4R38_RS10790	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4R38_RS10795	COG1288	antiporter activity
A4R38_RS10800	COG0280	phosphate acetyltransferase
A4R38_RS10800	COG0857	belongs to the CobB CobQ family
A4R38_RS10805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4R38_RS10825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS10830	COG0471	metal ion transport
A4R38_RS10830	COG0490	domain, Protein
A4R38_RS10840	COG0436	Aminotransferase
A4R38_RS10845	COG0583	DNA-binding transcription factor activity
A4R38_RS10865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A4R38_RS10870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4R38_RS10875	COG1034	ATP synthesis coupled electron transport
A4R38_RS10890	COG0839	Belongs to the complex I subunit 6 family
A4R38_RS10900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4R38_RS10905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R38_RS10920	COG2234	aminopeptidase activity
A4R38_RS10925	COG2304	oxidoreductase activity
A4R38_RS10935	COG2153	protein acetylation
A4R38_RS10940	COG4575	ribosome binding
A4R38_RS10945	COG1169	isochorismate synthase
A4R38_RS10960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4R38_RS10970	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS10990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R38_RS11035	COG1414	Transcriptional regulator
A4R38_RS11040	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS11045	COG2271	Major facilitator Superfamily
A4R38_RS11050	COG3836	Belongs to the HpcH HpaI aldolase family
A4R38_RS11060	COG5464	transposase or invertase
A4R38_RS11065	COG0247	lactate metabolic process
A4R38_RS11075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4R38_RS11080	COG2271	Major facilitator Superfamily
A4R38_RS11085	COG0584	glycerophosphoryl diester phosphodiesterase
A4R38_RS11090	COG3642	lipopolysaccharide core region biosynthetic process
A4R38_RS11095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R38_RS11100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS11105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R38_RS11115	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS11125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4R38_RS11130	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
A4R38_RS11135	COG3234	Protein of unknown function (DUF1175)
A4R38_RS11140	COG2373	Large extracellular alpha-helical protein
A4R38_RS11145	COG5445	Predicted secreted protein (DUF2300)
A4R38_RS11155	COG4382	Mu-like prophage protein Gp16
A4R38_RS11185	COG4396	Host-nuclease inhibitor protein Gam
A4R38_RS11195	COG3267	Type II secretory pathway component ExeA
A4R38_RS11195	COG3409	Peptidoglycan-binding domain 1 protein
A4R38_RS11280	COG4373	Mu-like prophage FluMu protein gp28
A4R38_RS11290	COG2369	cell adhesion
A4R38_RS11405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4R38_RS11410	COG5445	Predicted secreted protein (DUF2300)
A4R38_RS11415	COG4676	Protein conserved in bacteria
A4R38_RS11420	COG0183	Belongs to the thiolase family
A4R38_RS11425	COG2031	fatty acid transporter
A4R38_RS11430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4R38_RS11435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4R38_RS11440	COG2204	response regulator
A4R38_RS11445	COG3852	Histidine kinase
A4R38_RS11450	COG2205	protein histidine kinase activity
A4R38_RS11450	COG0784	Response regulator, receiver
A4R38_RS11455	COG2197	response regulator
A4R38_RS11460	COG0642	Histidine kinase
A4R38_RS11460	COG2198	Histidine kinase
A4R38_RS11480	COG1477	protein flavinylation
A4R38_RS11485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R38_RS11485	COG2169	Transcriptional regulator
A4R38_RS11490	COG3145	DNA-N1-methyladenine dioxygenase activity
A4R38_RS11495	COG4615	Cyclic peptide transporter
A4R38_RS11515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS11515	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4R38_RS11520	COG3062	negative regulation of establishment of protein localization
A4R38_RS11530	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS11535	COG0348	domain, Protein
A4R38_RS11540	COG3043	anaerobic respiration
A4R38_RS11545	COG3005	denitrification pathway
A4R38_RS11550	COG4133	protoheme IX ABC transporter activity
A4R38_RS11555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R38_RS11560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R38_RS11565	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R38_RS11575	COG1138	Cytochrome C-type biogenesis protein
A4R38_RS11580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R38_RS11585	COG3088	subunit of a heme lyase
A4R38_RS11585	COG4235	cytochrome complex assembly
A4R38_RS11590	COG2197	response regulator
A4R38_RS11600	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS11605	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS11615	COG3083	sulfuric ester hydrolase activity
A4R38_RS11635	COG1061	Type III restriction enzyme res subunit
A4R38_RS11640	COG1187	pseudouridine synthase activity
A4R38_RS11645	COG2814	Major facilitator Superfamily
A4R38_RS11655	COG4172	Belongs to the ABC transporter superfamily
A4R38_RS11660	COG4239	(ABC) transporter, permease
A4R38_RS11665	COG4174	ABC transporter (Permease)
A4R38_RS11670	COG4166	transmembrane transport
A4R38_RS11675	COG2200	EAL domain
A4R38_RS11680	COG0791	NLP P60 protein
A4R38_RS11685	COG0671	phosphoesterase, PA-phosphatase related
A4R38_RS11690	COG0523	cobalamin synthesis protein
A4R38_RS11695	COG0246	Mannitol dehydrogenase
A4R38_RS11710	COG2814	Major facilitator Superfamily
A4R38_RS11715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS11715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS11720	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R38_RS11725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS11725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4R38_RS11725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS11730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS11735	COG2313	pseudouridylate synthase activity
A4R38_RS11740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4R38_RS11745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS11755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS11755	COG1522	sequence-specific DNA binding
A4R38_RS11765	COG2855	membrane
A4R38_RS11770	COG0583	DNA-binding transcription factor activity
A4R38_RS11775	COG0833	amino acid
A4R38_RS11785	COG4771	TonB-dependent receptor
A4R38_RS11805	COG2311	Membrane
A4R38_RS11815	COG1609	Transcriptional regulator
A4R38_RS11820	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS11830	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS11835	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4R38_RS11835	COG0167	dihydroorotate dehydrogenase activity
A4R38_RS11840	COG0493	'glutamate synthase
A4R38_RS11850	COG2949	membrane
A4R38_RS11860	COG1346	cytolysis
A4R38_RS11870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4R38_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS11890	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS11900	COG1686	Belongs to the peptidase S11 family
A4R38_RS11905	COG0277	FAD linked oxidase domain protein
A4R38_RS11910	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R38_RS11915	COG1732	Glycine betaine
A4R38_RS11920	COG1174	glycine betaine transport
A4R38_RS11925	COG1125	glycine betaine transport
A4R38_RS11930	COG1174	glycine betaine transport
A4R38_RS11940	COG0789	Transcriptional regulator
A4R38_RS11945	COG3275	phosphorelay sensor kinase activity
A4R38_RS11950	COG3279	Response regulator of the LytR AlgR family
A4R38_RS11955	COG4807	Protein conserved in bacteria
A4R38_RS11960	COG4808	Protein conserved in bacteria
A4R38_RS11975	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4R38_RS11980	COG0714	Associated with various cellular activities
A4R38_RS11995	COG3831	ATPase activity
A4R38_RS12000	COG3831	ATPase activity
A4R38_RS12005	COG3831	ATPase activity
A4R38_RS12015	COG0489	protein tyrosine kinase activity
A4R38_RS12030	COG3539	Fimbrial protein
A4R38_RS12035	COG3121	Chaperone
A4R38_RS12040	COG3188	usher protein
A4R38_RS12045	COG3539	Fimbrial protein
A4R38_RS12050	COG5455	response to cobalt ion
A4R38_RS12070	COG0351	phosphomethylpyrimidine kinase
A4R38_RS12075	COG3757	hydrolase, family 25
A4R38_RS12080	COG2188	Transcriptional regulator
A4R38_RS12085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS12090	COG1397	ADP-ribosylglycohydrolase
A4R38_RS12095	COG2211	Major facilitator Superfamily
A4R38_RS12100	COG1830	Aldolase
A4R38_RS12115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS12120	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS12125	COG3775	system Galactitol-specific IIC component
A4R38_RS12130	COG1063	alcohol dehydrogenase
A4R38_RS12150	COG0826	peptidase U32
A4R38_RS12160	COG0745	RESPONSE REGULATOR receiver
A4R38_RS12165	COG2205	protein histidine kinase activity
A4R38_RS12190	COG4245	von Willebrand factor, type A
A4R38_RS12195	COG0631	protein serine/threonine phosphatase activity
A4R38_RS12200	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
A4R38_RS12205	COG0443	Heat shock 70 kDa protein
A4R38_RS12210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A4R38_RS12215	COG3447	MASE1 domain protein
A4R38_RS12215	COG5002	protein histidine kinase activity
A4R38_RS12215	COG5001	Diguanylate cyclase
A4R38_RS12220	COG0572	uridine kinase
A4R38_RS12230	COG2982	Protein involved in outer membrane biogenesis
A4R38_RS12235	COG1253	flavin adenine dinucleotide binding
A4R38_RS12240	COG1596	polysaccharide export
A4R38_RS12245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4R38_RS12250	COG0489	protein tyrosine kinase activity
A4R38_RS12250	COG3206	protein involved in exopolysaccharide biosynthesis
A4R38_RS12255	COG0463	Glycosyl transferase, family 2
A4R38_RS12260	COG1045	serine acetyltransferase
A4R38_RS12265	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS12275	COG1216	Glycosyl transferase, family 2
A4R38_RS12280	COG0110	maltose O-acetyltransferase activity
A4R38_RS12285	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A4R38_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS12295	COG1051	belongs to the nudix hydrolase family
A4R38_RS12300	COG0297	glycogen (starch) synthase activity
A4R38_RS12305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A4R38_RS12305	COG0662	Cupin 2, conserved barrel domain protein
A4R38_RS12310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4R38_RS12315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4R38_RS12320	COG2244	polysaccharide biosynthetic process
A4R38_RS12325	COG2327	Polysaccharide pyruvyl transferase
A4R38_RS12330	COG0438	transferase activity, transferring glycosyl groups
A4R38_RS12340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS12345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4R38_RS12350	COG1216	Glycosyl transferase, family 2
A4R38_RS12360	COG0463	Glycosyl transferase, family 2
A4R38_RS12390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4R38_RS12395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4R38_RS12400	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4R38_RS12405	COG0140	phosphoribosyl-ATP diphosphatase activity
A4R38_RS12405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4R38_RS12420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4R38_RS12425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4R38_RS12425	COG0131	Imidazoleglycerol-phosphate dehydratase
A4R38_RS12435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4R38_RS12445	COG2161	toxin-antitoxin pair type II binding
A4R38_RS12450	COG4115	mRNA cleavage
A4R38_RS12455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS12460	COG0583	DNA-binding transcription factor activity
A4R38_RS12465	COG0531	amino acid
A4R38_RS12470	COG2925	Exonuclease
A4R38_RS12475	COG1686	Belongs to the peptidase S11 family
A4R38_RS12485	COG1289	transmembrane transporter activity
A4R38_RS12500	COG4372	Transposase
A4R38_RS12505	COG4584	PFAM Integrase catalytic
A4R38_RS12510	COG1484	DNA-dependent DNA replication
A4R38_RS12540	COG2003	Belongs to the UPF0758 family
A4R38_RS12595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS12600	COG1120	ATPase activity
A4R38_RS12655	COG3547	Transposase (IS116 IS110 IS902 family)
A4R38_RS12665	COG4372	Transposase
A4R38_RS12670	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS12720	COG0405	Gamma-glutamyltransferase
A4R38_RS12725	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A4R38_RS12740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS12760	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS12765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R38_RS12770	COG3969	phosphoadenosine phosphosulfate
A4R38_RS12775	COG1475	DNA binding
A4R38_RS12780	COG4771	TonB-dependent receptor
A4R38_RS12790	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
A4R38_RS12805	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS12815	COG0583	DNA-binding transcription factor activity
A4R38_RS12820	COG0583	DNA-binding transcription factor activity
A4R38_RS12830	COG0534	Mate efflux family protein
A4R38_RS12840	COG0217	transcriptional regulatory protein
A4R38_RS12845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4R38_RS12850	COG0477	Major facilitator Superfamily
A4R38_RS12860	COG1662	PFAM IS1 transposase
A4R38_RS12865	COG1470	cell adhesion involved in biofilm formation
A4R38_RS12865	COG1388	LysM domain
A4R38_RS12870	COG1388	LysM domain
A4R38_RS12870	COG1470	cell adhesion involved in biofilm formation
A4R38_RS12875	COG1470	cell adhesion involved in biofilm formation
A4R38_RS12875	COG1388	LysM domain
A4R38_RS12880	COG4932	domain protein
A4R38_RS12880	COG2373	Large extracellular alpha-helical protein
A4R38_RS12880	COG1388	LysM domain
A4R38_RS12885	COG4771	TonB-dependent receptor
A4R38_RS12890	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4R38_RS12910	COG2226	methyltransferase
A4R38_RS12910	COG3433	isochorismatase activity
A4R38_RS12910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R38_RS12925	COG1132	(ABC) transporter
A4R38_RS12930	COG2814	Major facilitator Superfamily
A4R38_RS12935	COG1169	isochorismate synthase
A4R38_RS12940	COG1662	PFAM IS1 transposase
A4R38_RS12945	COG0582	viral genome integration into host DNA
A4R38_RS12970	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4R38_RS12985	COG2351	hydroxyisourate hydrolase activity
A4R38_RS12990	COG0745	RESPONSE REGULATOR receiver
A4R38_RS12995	COG2205	protein histidine kinase activity
A4R38_RS13010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4R38_RS13020	COG1418	mRNA catabolic process
A4R38_RS13025	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4R38_RS13030	COG3727	T/G mismatch-specific endonuclease activity
A4R38_RS13035	COG0697	spore germination
A4R38_RS13040	COG2354	Protein conserved in bacteria
A4R38_RS13045	COG5475	Uncharacterized small protein (DUF2158)
A4R38_RS13050	COG3706	GGDEF domain
A4R38_RS13070	COG2197	response regulator
A4R38_RS13075	COG1684	flagellar biosynthetic protein fliR
A4R38_RS13080	COG1987	bacterial-type flagellum assembly
A4R38_RS13085	COG1338	Plays a role in the flagellum-specific transport system
A4R38_RS13090	COG3190	flagellar
A4R38_RS13095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4R38_RS13100	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4R38_RS13105	COG1580	Controls the rotational direction of flagella during chemotaxis
A4R38_RS13110	COG3144	bacterial-type flagellum assembly
A4R38_RS13115	COG2882	bacterial-type flagellum organization
A4R38_RS13120	COG1157	protein secretion by the type III secretion system
A4R38_RS13125	COG1317	bacterial-type flagellum organization
A4R38_RS13130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4R38_RS13135	COG1766	The M ring may be actively involved in energy transduction
A4R38_RS13150	COG2076	Multidrug Resistance protein
A4R38_RS13155	COG1881	PFAM PEBP family protein
A4R38_RS13160	COG2207	Transcriptional regulator
A4R38_RS13170	COG0675	Transposase, IS605 OrfB family
A4R38_RS13180	COG0425	Belongs to the sulfur carrier protein TusA family
A4R38_RS13185	COG2391	methyltransferase activity
A4R38_RS13195	COG0366	Alpha amylase catalytic
A4R38_RS13205	COG1516	flagellar protein fliS
A4R38_RS13210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A4R38_RS13220	COG1191	sigma factor activity
A4R38_RS13230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS13240	COG0765	amino acid transport
A4R38_RS13245	COG1126	abc transporter atp-binding protein
A4R38_RS13250	COG2197	response regulator
A4R38_RS13265	COG2197	response regulator
A4R38_RS13295	COG3012	SEC-C Motif Domain Protein
A4R38_RS13295	COG3318	Belongs to the UPF0149 family
A4R38_RS13300	COG0814	amino acid
A4R38_RS13310	COG1528	Iron-storage protein
A4R38_RS13330	COG1528	Iron-storage protein
A4R38_RS13335	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS13345	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS13350	COG1877	trehalose-phosphatase activity
A4R38_RS13360	COG0589	response to stress
A4R38_RS13375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A4R38_RS13380	COG1360	Flagellar Motor Protein
A4R38_RS13385	COG2198	Histidine kinase
A4R38_RS13385	COG0643	Histidine kinase
A4R38_RS13390	COG0835	chemotaxis
A4R38_RS13395	COG0840	transmembrane signaling receptor activity
A4R38_RS13400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A4R38_RS13410	COG0745	RESPONSE REGULATOR receiver
A4R38_RS13415	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A4R38_RS13420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4R38_RS13425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4R38_RS13440	COG3102	Protein conserved in bacteria
A4R38_RS13450	COG3005	denitrification pathway
A4R38_RS13455	COG0243	molybdopterin cofactor binding
A4R38_RS13470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A4R38_RS13475	COG1801	Protein of unknown function DUF72
A4R38_RS13480	COG1335	isochorismatase
A4R38_RS13490	COG0494	nUDIX hydrolase
A4R38_RS13495	COG0217	transcriptional regulatory protein
A4R38_RS13525	COG2801	Transposase and inactivated derivatives
A4R38_RS13530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS13540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A4R38_RS13545	COG0739	heme binding
A4R38_RS13550	COG1560	Kdo2-lipid A biosynthetic process
A4R38_RS13555	COG0469	pyruvate kinase activity
A4R38_RS13560	COG1737	Transcriptional regulator
A4R38_RS13570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4R38_RS13575	COG0129	dihydroxy-acid dehydratase activity
A4R38_RS13580	COG0800	Aldolase
A4R38_RS13590	COG3141	response to X-ray
A4R38_RS13605	COG2979	Protein of unknown function (DUF533)
A4R38_RS13610	COG1770	oligopeptidase
A4R38_RS13615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS13620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R38_RS13630	COG2372	response to copper ion
A4R38_RS13635	COG1276	copper resistance
A4R38_RS13650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R38_RS13670	COG3008	intermembrane lipid transfer
A4R38_RS13675	COG2995	paraquat-inducible protein a
A4R38_RS13680	COG1956	GAF domain-containing protein
A4R38_RS13690	COG0793	Belongs to the peptidase S41A family
A4R38_RS13700	COG2814	Major facilitator Superfamily
A4R38_RS13705	COG1414	Transcriptional regulator
A4R38_RS13740	COG2226	methyltransferase
A4R38_RS13760	COG3716	PTS system mannose fructose sorbose family IID component
A4R38_RS13765	COG3715	PTS system
A4R38_RS13770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS13770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS13780	COG1253	flavin adenine dinucleotide binding
A4R38_RS13785	COG2200	EAL domain
A4R38_RS13790	COG1760	l-serine dehydratase
A4R38_RS13800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4R38_RS13820	COG0251	oxidation-reduction process
A4R38_RS13825	COG1199	ATP-dependent helicase activity
A4R38_RS13830	COG1214	PFAM Peptidase M22, glycoprotease
A4R38_RS13835	COG3065	identical protein binding
A4R38_RS13840	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS13845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4R38_RS13850	COG0473	3-isopropylmalate dehydrogenase activity
A4R38_RS13855	COG0583	DNA-binding transcription factor activity
A4R38_RS13865	COG3615	Tellurite resistance protein tehB
A4R38_RS13875	COG2261	transglycosylase associated protein
A4R38_RS13885	COG2199	diguanylate cyclase activity
A4R38_RS13885	COG2203	Gaf domain
A4R38_RS13890	COG3042	response to heat
A4R38_RS13895	COG3189	MarR family transcriptional regulator
A4R38_RS13900	COG2807	transmembrane transport
A4R38_RS13905	COG2207	Transcriptional regulator
A4R38_RS13920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4R38_RS13925	COG2199	diguanylate cyclase activity
A4R38_RS13930	COG2199	diguanylate cyclase activity
A4R38_RS13940	COG2766	serine protein kinase
A4R38_RS13945	COG3713	MltA-interacting MipA family protein
A4R38_RS13950	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS13955	COG0676	glucose-6-phosphate 1-epimerase activity
A4R38_RS13960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4R38_RS13970	COG3139	Protein of unknown function (DUF1315)
A4R38_RS13975	COG1063	alcohol dehydrogenase
A4R38_RS13980	COG2271	Major facilitator Superfamily
A4R38_RS13985	COG1063	alcohol dehydrogenase
A4R38_RS13990	COG0191	fructose-bisphosphate aldolase activity
A4R38_RS13995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS14000	COG0667	Aldo Keto reductase
A4R38_RS14005	COG1349	DNA-binding transcription factor activity
A4R38_RS14010	COG2814	Major facilitator Superfamily
A4R38_RS14015	COG1335	isochorismatase
A4R38_RS14020	COG0252	asparaginase activity
A4R38_RS14030	COG0616	signal peptide processing
A4R38_RS14040	COG0778	Nitroreductase
A4R38_RS14050	COG0709	Synthesizes selenophosphate from selenide and ATP
A4R38_RS14055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4R38_RS14060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4R38_RS14070	COG0494	nUDIX hydrolase
A4R38_RS14075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4R38_RS14080	COG2897	thiosulfate sulfurtransferase activity
A4R38_RS14085	COG4136	ATPase activity
A4R38_RS14090	COG4135	transport system, permease component
A4R38_RS14095	COG4134	Bacterial extracellular solute-binding protein
A4R38_RS14100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R38_RS14105	COG0398	Pfam SNARE associated Golgi protein
A4R38_RS14115	COG0398	Pfam SNARE associated Golgi protein
A4R38_RS14120	COG0708	Exodeoxyribonuclease III
A4R38_RS14150	COG3678	ATP-independent chaperone mediated protein folding
A4R38_RS14160	COG0322	excinuclease ABC activity
A4R38_RS14175	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R38_RS14180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4R38_RS14185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4R38_RS14190	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4R38_RS14195	COG1917	Cupin 2, conserved barrel domain protein
A4R38_RS14195	COG2169	Transcriptional regulator
A4R38_RS14200	COG1486	melibiose metabolic process
A4R38_RS14205	COG3394	polysaccharide catabolic process
A4R38_RS14210	COG0753	catalase activity
A4R38_RS14220	COG1823	symporter activity
A4R38_RS14225	COG1988	membrane-bound metal-dependent
A4R38_RS14230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS14240	COG3001	Fructosamine kinase
A4R38_RS14250	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R38_RS14255	COG3137	Salt-induced outer membrane protein
A4R38_RS14315	COG0386	Belongs to the glutathione peroxidase family
A4R38_RS14325	COG0791	NLP P60 protein
A4R38_RS14330	COG2200	EAL domain
A4R38_RS14340	COG4256	Hemin uptake protein
A4R38_RS14345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R38_RS14360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS14360	COG0574	Belongs to the PEP-utilizing enzyme family
A4R38_RS14365	COG0318	PFAM AMP-dependent synthetase and ligase
A4R38_RS14370	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4R38_RS14375	COG0644	oxidoreductase
A4R38_RS14380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4R38_RS14385	COG2086	electron transfer activity
A4R38_RS14395	COG1917	Cupin 2, conserved barrel domain protein
A4R38_RS14395	COG2207	Transcriptional regulator
A4R38_RS14400	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS14405	COG4670	ketone body catabolic process
A4R38_RS14420	COG2271	Major facilitator Superfamily
A4R38_RS14425	COG0738	Major facilitator superfamily
A4R38_RS14440	COG0628	permease
A4R38_RS14445	COG0247	lactate metabolic process
A4R38_RS14445	COG0277	FAD linked oxidase domain protein
A4R38_RS14450	COG2050	protein possibly involved in aromatic compounds catabolism
A4R38_RS14460	COG0316	Belongs to the HesB IscA family
A4R38_RS14465	COG0719	Fe-S assembly protein
A4R38_RS14470	COG0396	ATPase activity
A4R38_RS14475	COG0719	Fe-S assembly protein
A4R38_RS14490	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS14495	COG4238	major outer membrane lipoprotein
A4R38_RS14500	COG0469	pyruvate kinase activity
A4R38_RS14510	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS14515	COG2414	aldehyde ferredoxin oxidoreductase
A4R38_RS14525	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS14530	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A4R38_RS14540	COG4529	Protein conserved in bacteria
A4R38_RS14560	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS14570	COG0307	riboflavin synthase, alpha
A4R38_RS14575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R38_RS14580	COG2814	Major facilitator Superfamily
A4R38_RS14585	COG0583	DNA-binding transcription factor activity
A4R38_RS14600	COG2814	Major facilitator Superfamily
A4R38_RS14605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4R38_RS14610	COG0791	NLP P60 protein
A4R38_RS14615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4R38_RS14620	COG1201	RNA secondary structure unwinding
A4R38_RS14630	COG0346	lactoylglutathione lyase activity
A4R38_RS14635	COG1902	pentaerythritol trinitrate reductase activity
A4R38_RS14640	COG1309	transcriptional regulator
A4R38_RS14645	COG3313	Fe-S protein
A4R38_RS14650	COG4989	oxidoreductase activity
A4R38_RS14655	COG2032	superoxide dismutase activity
A4R38_RS14660	COG1289	transmembrane transporter activity
A4R38_RS14665	COG1289	transmembrane transporter activity
A4R38_RS14670	COG1566	PFAM secretion protein HlyD family protein
A4R38_RS14685	COG3133	Outer membrane lipoprotein
A4R38_RS14695	COG3895	Periplasmic Protein
A4R38_RS14715	COG0625	glutathione transferase activity
A4R38_RS14720	COG3104	oligopeptide transport
A4R38_RS14730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4R38_RS14740	COG4659	FMN binding
A4R38_RS14780	COG0673	inositol 2-dehydrogenase activity
A4R38_RS14790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4R38_RS14795	COG1263	PTS System
A4R38_RS14795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS14800	COG1609	Transcriptional regulator
A4R38_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS14810	COG1309	transcriptional regulator
A4R38_RS14815	COG3250	beta-galactosidase activity
A4R38_RS14830	COG5339	Protein conserved in bacteria
A4R38_RS14835	COG1482	cell wall glycoprotein biosynthetic process
A4R38_RS14840	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS14840	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4R38_RS14845	COG0114	fumarate hydratase activity
A4R38_RS14855	COG2205	protein histidine kinase activity
A4R38_RS14860	COG0745	RESPONSE REGULATOR receiver
A4R38_RS14865	COG3136	membrane protein required for alginate biosynthesis
A4R38_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS14875	COG0531	amino acid
A4R38_RS14885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4R38_RS14890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A4R38_RS14895	COG0628	permease
A4R38_RS14910	COG3591	Belongs to the peptidase S1B family
A4R38_RS14925	COG2814	Major facilitator Superfamily
A4R38_RS14930	COG0583	DNA-binding transcription factor activity
A4R38_RS14935	COG1940	carbohydrate kinase activity
A4R38_RS14940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R38_RS14950	COG3381	protein complex oligomerization
A4R38_RS14955	COG3302	dmso reductase anchor subunit
A4R38_RS14960	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS14970	COG0243	molybdopterin cofactor binding
A4R38_RS14985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS15000	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS15005	COG1063	alcohol dehydrogenase
A4R38_RS15010	COG0582	viral genome integration into host DNA
A4R38_RS15020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS15045	COG1396	sequence-specific DNA binding
A4R38_RS15060	COG1846	Transcriptional regulator
A4R38_RS15070	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4R38_RS15085	COG2801	Transposase and inactivated derivatives
A4R38_RS15095	COG3077	Addiction module antitoxin, RelB DinJ family
A4R38_RS15100	COG2026	Addiction module toxin, RelE StbE family
A4R38_RS15120	COG1403	HNH endonuclease
A4R38_RS15125	COG0484	heat shock protein binding
A4R38_RS15130	COG1278	Cold shock
A4R38_RS15135	COG1278	Cold shock
A4R38_RS15150	COG3772	lysozyme
A4R38_RS15160	COG1278	Cold shock
A4R38_RS15175	COG5562	phage envelope protein
A4R38_RS15185	COG4220	transposase activity
A4R38_RS15205	COG1030	water channel activity
A4R38_RS15255	COG1196	nuclear chromosome segregation
A4R38_RS15290	COG5301	cellulose 1,4-beta-cellobiosidase activity
A4R38_RS15310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4R38_RS15320	COG0477	Major facilitator Superfamily
A4R38_RS15325	COG0246	Mannitol dehydrogenase
A4R38_RS15335	COG1802	Transcriptional regulator
A4R38_RS15340	COG4221	oxidoreductase activity
A4R38_RS15345	COG0339	signal peptide processing
A4R38_RS15350	COG3111	PFAM Bacterial OB fold (BOF) protein
A4R38_RS15355	COG3706	GGDEF domain
A4R38_RS15365	COG2814	Major facilitator Superfamily
A4R38_RS15370	COG0697	spore germination
A4R38_RS15380	COG4977	sequence-specific DNA binding
A4R38_RS15385	COG1846	Transcriptional regulator
A4R38_RS15400	COG0583	DNA-binding transcription factor activity
A4R38_RS15405	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS15410	COG2066	Belongs to the glutaminase family
A4R38_RS15420	COG2199	diguanylate cyclase activity
A4R38_RS15435	COG3781	membrane
A4R38_RS15445	COG1396	sequence-specific DNA binding
A4R38_RS15450	COG3550	peptidyl-serine autophosphorylation
A4R38_RS15455	COG3188	usher protein
A4R38_RS15460	COG3539	Fimbrial protein
A4R38_RS15465	COG3539	Fimbrial protein
A4R38_RS15470	COG3539	Fimbrial protein
A4R38_RS15475	COG0243	molybdopterin cofactor binding
A4R38_RS15485	COG2207	Transcriptional regulator
A4R38_RS15490	COG3119	arylsulfatase activity
A4R38_RS15495	COG0641	radical SAM
A4R38_RS15500	COG0612	Peptidase, M16
A4R38_RS15510	COG0076	glutamate decarboxylase activity
A4R38_RS15515	COG0531	amino acid
A4R38_RS15520	COG1649	PFAM Uncharacterised BCR, COG1649
A4R38_RS15525	COG3706	GGDEF domain
A4R38_RS15525	COG3706	GGDEF domain
A4R38_RS15530	COG2199	diguanylate cyclase activity
A4R38_RS15530	COG2200	EAL domain
A4R38_RS15530	COG2202	Pas domain
A4R38_RS15535	COG1764	response to oxidative stress
A4R38_RS15555	COG1064	alcohol dehydrogenase
A4R38_RS15565	COG3093	addiction module antidote protein HigA
A4R38_RS15570	COG2864	formate dehydrogenase
A4R38_RS15575	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS15580	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS15580	COG0243	molybdopterin cofactor binding
A4R38_RS15585	COG0243	molybdopterin cofactor binding
A4R38_RS15585	COG3383	formate dehydrogenase (NAD+) activity
A4R38_RS15590	COG0697	spore germination
A4R38_RS15595	COG2223	nitrite transmembrane transporter activity
A4R38_RS15600	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4R38_RS15605	COG1140	nitrate reductase beta subunit
A4R38_RS15610	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4R38_RS15615	COG2181	nitrate reductase activity
A4R38_RS15620	COG0384	phenazine biosynthesis protein PhzF
A4R38_RS15625	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4R38_RS15630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4R38_RS15635	COG5433	transposase activity
A4R38_RS15640	COG1113	amino acid transport
A4R38_RS15650	COG4772	TonB-dependent receptor
A4R38_RS15655	COG1802	Transcriptional regulator
A4R38_RS15660	COG1247	-acetyltransferase
A4R38_RS15665	COG3238	Protein conserved in bacteria
A4R38_RS15690	COG1177	transmembrane transport
A4R38_RS15695	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4R38_RS15700	COG3842	ATPase activity
A4R38_RS15705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4R38_RS15710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R38_RS15715	COG1598	PFAM Uncharacterised protein family UPF0150
A4R38_RS15725	COG0826	peptidase U32
A4R38_RS15730	COG1396	sequence-specific DNA binding
A4R38_RS15735	COG3135	benzoate transporter
A4R38_RS15745	COG0500	methyltransferase
A4R38_RS15750	COG1275	C4-dicarboxylate transporter malic acid transport protein
A4R38_RS15755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4R38_RS15760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS15765	COG2841	Protein conserved in bacteria
A4R38_RS15780	COG5383	Protein conserved in bacteria
A4R38_RS15785	COG0583	DNA-binding transcription factor activity
A4R38_RS15790	COG0840	transmembrane signaling receptor activity
A4R38_RS15810	COG3038	cytochrome b561
A4R38_RS15815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4R38_RS15820	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS15825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4R38_RS15830	COG1643	Atp-dependent helicase
A4R38_RS15840	COG0667	Aldo Keto reductase
A4R38_RS15855	COG3784	Protein of unknown function (DUF1318)
A4R38_RS15865	COG2911	Protein conserved in bacteria
A4R38_RS15870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4R38_RS15875	COG3187	Heat shock protein
A4R38_RS15880	COG3042	response to heat
A4R38_RS15885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4R38_RS15885	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4R38_RS15885	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4R38_RS15885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R38_RS15890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4R38_RS15895	COG0589	response to stress
A4R38_RS15905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS15910	COG0582	viral genome integration into host DNA
A4R38_RS15920	COG0513	Belongs to the DEAD box helicase family
A4R38_RS15935	COG3706	GGDEF domain
A4R38_RS15940	COG2840	Smr protein MutS2
A4R38_RS15955	COG2207	Transcriptional regulator
A4R38_RS15965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4R38_RS15970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R38_RS15975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS15980	COG0589	response to stress
A4R38_RS15985	COG3182	Iron-regulated membrane protein
A4R38_RS15990	COG0668	transmembrane transport
A4R38_RS15995	COG4166	transmembrane transport
A4R38_RS16005	COG0583	DNA-binding transcription factor activity
A4R38_RS16010	COG1662	PFAM IS1 transposase
A4R38_RS16010	COG3677	Transposase
A4R38_RS16015	COG1073	alpha beta
A4R38_RS16020	COG0702	epimerase
A4R38_RS16025	COG2866	Carboxypeptidase
A4R38_RS16030	COG4948	Mandelate Racemase Muconate Lactonizing
A4R38_RS16035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4R38_RS16040	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A4R38_RS16050	COG3106	COG3106 Predicted ATPase
A4R38_RS16055	COG1609	Transcriptional regulator
A4R38_RS16070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R38_RS16075	COG1554	hydrolase, family 65, central catalytic
A4R38_RS16080	COG0673	inositol 2-dehydrogenase activity
A4R38_RS16085	COG1082	Xylose isomerase domain protein TIM barrel
A4R38_RS16090	COG1063	alcohol dehydrogenase
A4R38_RS16095	COG0395	ABC-type sugar transport system, permease component
A4R38_RS16100	COG1175	transmembrane transport
A4R38_RS16105	COG1653	transport
A4R38_RS16110	COG0366	Alpha amylase catalytic
A4R38_RS16115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4R38_RS16125	COG1983	PspC domain protein
A4R38_RS16135	COG1842	Phage shock protein A
A4R38_RS16140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4R38_RS16155	COG4166	transmembrane transport
A4R38_RS16160	COG4168	peptide transport system, permease
A4R38_RS16165	COG4171	peptide transport system, permease
A4R38_RS16170	COG4172	Belongs to the ABC transporter superfamily
A4R38_RS16175	COG4172	Belongs to the ABC transporter superfamily
A4R38_RS16180	COG2814	Major facilitator Superfamily
A4R38_RS16190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS16195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS16205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4R38_RS16210	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R38_RS16210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R38_RS16225	COG5001	Diguanylate cyclase
A4R38_RS16235	COG1349	DNA-binding transcription factor activity
A4R38_RS16245	COG0023	Translation Initiation Factor
A4R38_RS16255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4R38_RS16260	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A4R38_RS16265	COG0671	phosphoesterase, PA-phosphatase related
A4R38_RS16275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R38_RS16295	COG0583	DNA-binding transcription factor activity
A4R38_RS16300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4R38_RS16315	COG0616	signal peptide processing
A4R38_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS16330	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4R38_RS16345	COG1187	pseudouridine synthase activity
A4R38_RS16350	COG4907	membrane protein (DUF2207)
A4R38_RS16355	COG0009	L-threonylcarbamoyladenylate synthase
A4R38_RS16360	COG0613	PHP domain protein
A4R38_RS16365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4R38_RS16370	COG0512	Glutamine amidotransferase of anthranilate synthase
A4R38_RS16370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4R38_RS16375	COG0134	indole-3-glycerol-phosphate synthase activity
A4R38_RS16375	COG0135	phosphoribosylanthranilate isomerase activity
A4R38_RS16390	COG3047	cAMP biosynthetic process
A4R38_RS16405	COG1607	acyl-coa hydrolase
A4R38_RS16415	COG2350	Protein conserved in bacteria
A4R38_RS16420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4R38_RS16440	COG4608	Belongs to the ABC transporter superfamily
A4R38_RS16445	COG0444	Belongs to the ABC transporter superfamily
A4R38_RS16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R38_RS16455	COG0601	transmembrane transport
A4R38_RS16460	COG4166	transmembrane transport
A4R38_RS16465	COG2095	MarC family integral membrane protein
A4R38_RS16470	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS16470	COG1454	alcohol dehydrogenase
A4R38_RS16475	COG3385	transposase activity
A4R38_RS16480	COG3385	transposase activity
A4R38_RS16485	COG1435	thymidine kinase activity
A4R38_RS16495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4R38_RS16500	COG0745	RESPONSE REGULATOR receiver
A4R38_RS16505	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4R38_RS16515	COG0788	formyltetrahydrofolate deformylase activity
A4R38_RS16555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS16560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R38_RS16565	COG2181	nitrate reductase activity
A4R38_RS16570	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4R38_RS16575	COG1140	nitrate reductase beta subunit
A4R38_RS16580	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4R38_RS16585	COG2223	nitrite transmembrane transporter activity
A4R38_RS16595	COG3850	Histidine kinase
A4R38_RS16600	COG2197	response regulator
A4R38_RS16605	COG4932	domain protein
A4R38_RS16610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4R38_RS16615	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A4R38_RS16620	COG4572	Cation transport regulator
A4R38_RS16625	COG0387	Pfam Sodium calcium exchanger
A4R38_RS16640	COG2912	Transglutaminase-like superfamily
A4R38_RS16645	COG3094	Invasion gene expression up-regulator, SirB
A4R38_RS16650	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R38_RS16675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4R38_RS16680	COG0659	secondary active sulfate transmembrane transporter activity
A4R38_RS16695	COG0012	GTP binding
A4R38_RS16700	COG0582	viral genome integration into host DNA
A4R38_RS16710	COG2801	Transposase and inactivated derivatives
A4R38_RS16740	COG2826	transposase and inactivated derivatives, IS30 family
A4R38_RS16770	COG4974	Belongs to the 'phage' integrase family
A4R38_RS16775	COG2003	Belongs to the UPF0758 family
A4R38_RS16840	COG3284	Transcriptional regulator
A4R38_RS16845	COG2376	Dihydroxyacetone kinase
A4R38_RS16850	COG1461	Dihydroxyacetone kinase
A4R38_RS16855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R38_RS16855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS16855	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A4R38_RS16865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R38_RS16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS16875	COG1120	ATPase activity
A4R38_RS16880	COG0500	methyltransferase
A4R38_RS16885	COG0157	Belongs to the NadC ModD family
A4R38_RS16900	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A4R38_RS16910	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4R38_RS16920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4R38_RS16930	COG2719	SpoVR family
A4R38_RS16940	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R38_RS16950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4R38_RS16955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4R38_RS16970	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R38_RS17000	COG2894	cell division
A4R38_RS17055	COG2200	EAL domain
A4R38_RS17080	COG2200	EAL domain
A4R38_RS17085	COG0789	Transcriptional regulator
A4R38_RS17090	COG5562	phage envelope protein
A4R38_RS17105	COG1121	(ABC) transporter
A4R38_RS17110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS17115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R38_RS17130	COG4372	Transposase
A4R38_RS17135	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS17145	COG5301	cellulose 1,4-beta-cellobiosidase activity
A4R38_RS17175	COG1196	nuclear chromosome segregation
A4R38_RS17245	COG4220	transposase activity
A4R38_RS17270	COG3772	lysozyme
A4R38_RS17335	COG2076	Multidrug Resistance protein
A4R38_RS17435	COG0582	viral genome integration into host DNA
A4R38_RS17440	COG0538	isocitrate dehydrogenase activity
A4R38_RS17445	COG1187	pseudouridine synthase activity
A4R38_RS17465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4R38_RS17475	COG2205	protein histidine kinase activity
A4R38_RS17480	COG2850	peptidyl-arginine hydroxylation
A4R38_RS17495	COG3842	ATPase activity
A4R38_RS17510	COG0500	methyltransferase
A4R38_RS17515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R38_RS17520	COG5301	cellulose 1,4-beta-cellobiosidase activity
A4R38_RS17630	COG4220	transposase activity
A4R38_RS17665	COG3772	lysozyme
A4R38_RS17715	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A4R38_RS17720	COG1403	HNH endonuclease
A4R38_RS17780	COG1846	Transcriptional regulator
A4R38_RS17785	COG1484	DNA-dependent DNA replication
A4R38_RS17790	COG1846	Transcriptional regulator
A4R38_RS17850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS17860	COG0582	viral genome integration into host DNA
A4R38_RS17865	COG1177	transmembrane transport
A4R38_RS17870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4R38_RS17880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4R38_RS17885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4R38_RS17895	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4R38_RS17905	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4R38_RS17910	COG4763	Acyl-transferase
A4R38_RS17915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4R38_RS17920	COG1388	LysM domain
A4R38_RS17920	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS17930	COG1309	transcriptional regulator
A4R38_RS17935	COG3134	Outer membrane lipoprotein
A4R38_RS17940	COG1252	NADH dehydrogenase
A4R38_RS17955	COG0510	thiamine kinase activity
A4R38_RS17960	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A4R38_RS17965	COG5633	Lipoprotein
A4R38_RS17970	COG0537	adenosine 5'-monophosphoramidase activity
A4R38_RS17975	COG4773	Receptor
A4R38_RS17980	COG1263	PTS System
A4R38_RS17980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS17985	COG0084	hydrolase, TatD family'
A4R38_RS17990	COG0470	DNA polymerase III
A4R38_RS18000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4R38_RS18005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R38_RS18010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4R38_RS18020	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS18025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4R38_RS18045	COG1399	metal-binding, possibly nucleic acid-binding protein
A4R38_RS18050	COG0424	maF-like protein
A4R38_RS18055	COG0564	pseudouridine synthase activity
A4R38_RS18065	COG1530	ribonuclease E activity
A4R38_RS18070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4R38_RS18075	COG1256	bacterial-type flagellum assembly
A4R38_RS18080	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4R38_RS18080	COG3951	Flagellar rod assembly protein muramidase FlgJ
A4R38_RS18095	COG4786	Flagellar basal body rod
A4R38_RS18100	COG4787	bacterial-type flagellum-dependent cell motility
A4R38_RS18105	COG1749	Flagellar hook protein flgE
A4R38_RS18110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A4R38_RS18115	COG1558	bacterial-type flagellum-dependent cell motility
A4R38_RS18120	COG1815	bacterial-type flagellum-dependent cell motility
A4R38_RS18125	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A4R38_RS18130	COG2747	anti-sigma28 factor FlgM
A4R38_RS18135	COG3418	PFAM FlgN family protein
A4R38_RS18140	COG0728	peptidoglycan biosynthetic process
A4R38_RS18145	COG0673	inositol 2-dehydrogenase activity
A4R38_RS18155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R38_RS18165	COG2999	glutathione oxidoreductase activity
A4R38_RS18200	COG3038	cytochrome b561
A4R38_RS18205	COG2353	YceI-like domain
A4R38_RS18215	COG1560	Kdo2-lipid A biosynthetic process
A4R38_RS18235	COG5645	(Lipo)protein
A4R38_RS18240	COG2943	transferase activity, transferring hexosyl groups
A4R38_RS18265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS18270	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R38_RS18300	COG2197	response regulator
A4R38_RS18315	COG1462	curli production assembly transport component CsgG
A4R38_RS18325	COG3381	protein complex oligomerization
A4R38_RS18350	COG3706	GGDEF domain
A4R38_RS18355	COG0457	Tetratricopeptide repeat
A4R38_RS18360	COG1649	PFAM Uncharacterised BCR, COG1649
A4R38_RS18360	COG0726	polysaccharide deacetylase
A4R38_RS18365	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS18370	COG3658	cytochrome
A4R38_RS18375	COG1702	phosphate starvation-inducible protein PhoH
A4R38_RS18395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R38_RS18405	COG0506	proline dehydrogenase activity
A4R38_RS18405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS18405	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4R38_RS18410	COG1309	transcriptional regulator
A4R38_RS18445	COG2233	PERMEase
A4R38_RS18450	COG3729	General stress protein
A4R38_RS18490	COG0243	molybdopterin cofactor binding
A4R38_RS18495	COG3005	denitrification pathway
A4R38_RS18500	COG0745	RESPONSE REGULATOR receiver
A4R38_RS18505	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS18510	COG2198	Histidine kinase
A4R38_RS18510	COG0784	Response regulator, receiver
A4R38_RS18510	COG2205	protein histidine kinase activity
A4R38_RS18515	COG0348	domain, Protein
A4R38_RS18530	COG1278	Cold shock
A4R38_RS18535	COG1278	Cold shock
A4R38_RS18550	COG1294	oxidase, subunit
A4R38_RS18555	COG1271	oxidase subunit
A4R38_RS18560	COG1773	rubredoxin
A4R38_RS18565	COG1999	signal sequence binding
A4R38_RS18570	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4R38_RS18575	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A4R38_RS18580	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A4R38_RS18585	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A4R38_RS18595	COG0670	Belongs to the BI1 family
A4R38_RS18600	COG2920	part of a sulfur-relay system
A4R38_RS18605	COG1254	Belongs to the acylphosphatase family
A4R38_RS18620	COG1832	CoA-binding protein
A4R38_RS18640	COG0210	DNA helicase
A4R38_RS18645	COG3304	Inner membrane component domain
A4R38_RS18650	COG1289	transmembrane transporter activity
A4R38_RS18655	COG3070	regulator of competence-specific genes
A4R38_RS18680	COG1067	ATP-dependent peptidase activity
A4R38_RS18690	COG3130	regulation of translation
A4R38_RS18695	COG3009	Protein conserved in bacteria
A4R38_RS18700	COG3008	intermembrane lipid transfer
A4R38_RS18700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4R38_RS18705	COG2995	paraquat-inducible protein a
A4R38_RS18710	COG0488	(ABC) transporter
A4R38_RS18720	COG3217	Mosc domain protein beta barrel domain protein
A4R38_RS18720	COG0633	Ferredoxin
A4R38_RS18735	COG0431	NADPH-dependent FMN reductase
A4R38_RS18740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R38_RS18750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R38_RS18755	COG1116	anion transmembrane transporter activity
A4R38_RS18760	COG0308	aminopeptidase N
A4R38_RS18785	COG1448	Aminotransferase
A4R38_RS18790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R38_RS18795	COG3108	Peptidase M15
A4R38_RS18800	COG2989	Protein conserved in bacteria
A4R38_RS18810	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A4R38_RS18820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4R38_RS18825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4R38_RS18830	COG3173	Aminoglycoside phosphotransferase
A4R38_RS18845	COG3214	Protein conserved in bacteria
A4R38_RS18860	COG2333	competence protein COMEC
A4R38_RS18860	COG0658	competence protein
A4R38_RS18870	COG0539	negative regulation of cytoplasmic translation
A4R38_RS18880	COG0501	Belongs to the peptidase M48B family
A4R38_RS18895	COG2323	membrane
A4R38_RS18900	COG1944	ATP diphosphatase activity
A4R38_RS18905	COG2116	formate transmembrane transporter activity
A4R38_RS18910	COG1882	Formate acetyltransferase
A4R38_RS18915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS18925	COG1335	isochorismatase
A4R38_RS18930	COG3302	dmso reductase anchor subunit
A4R38_RS18935	COG0437	4 iron, 4 sulfur cluster binding
A4R38_RS18940	COG0243	molybdopterin cofactor binding
A4R38_RS18950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4R38_RS18965	COG1522	sequence-specific DNA binding
A4R38_RS18970	COG0492	ferredoxin-NADP+ reductase activity
A4R38_RS18975	COG4988	ABC transporter
A4R38_RS18980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4R38_RS19000	COG0542	response to heat
A4R38_RS19010	COG1278	Cold shock
A4R38_RS19020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS19025	COG2990	Protein conserved in bacteria
A4R38_RS19030	COG3593	DNA synthesis involved in DNA repair
A4R38_RS19040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4R38_RS19045	COG2431	L-lysine efflux transmembrane transporter activity
A4R38_RS19050	COG1151	hydroxylamine reductase activity
A4R38_RS19055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R38_RS19060	COG0028	Belongs to the TPP enzyme family
A4R38_RS19065	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A4R38_RS19070	COG0702	epimerase
A4R38_RS19075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R38_RS19080	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS19095	COG1126	abc transporter atp-binding protein
A4R38_RS19100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS19105	COG4215	(ABC) transporter
A4R38_RS19110	COG4160	amino acid transport
A4R38_RS19115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS19130	COG1177	transmembrane transport
A4R38_RS19135	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4R38_RS19140	COG3842	ATPase activity
A4R38_RS19145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4R38_RS19165	COG0778	Nitroreductase
A4R38_RS19175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4R38_RS19190	COG3226	Transcriptional regulator
A4R38_RS19195	COG0738	Major facilitator superfamily
A4R38_RS19200	COG0561	phosphatase activity
A4R38_RS19210	COG2814	Major facilitator Superfamily
A4R38_RS19215	COG0671	phosphoesterase, PA-phosphatase related
A4R38_RS19220	COG1349	DNA-binding transcription factor activity
A4R38_RS19225	COG1686	Belongs to the peptidase S11 family
A4R38_RS19230	COG0625	glutathione transferase activity
A4R38_RS19235	COG2133	pyrroloquinoline quinone binding
A4R38_RS19250	COG2199	diguanylate cyclase activity
A4R38_RS19280	COG1446	asparaginase
A4R38_RS19285	COG0303	'Molybdopterin
A4R38_RS19290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4R38_RS19295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R38_RS19300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS19305	COG1882	Formate acetyltransferase
A4R38_RS19310	COG0561	phosphatase activity
A4R38_RS19315	COG0488	(ABC) transporter
A4R38_RS19320	COG1376	ErfK ybiS ycfS ynhG family protein
A4R38_RS19325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4R38_RS19330	COG1321	iron dependent repressor
A4R38_RS19340	COG2194	sulfuric ester hydrolase activity
A4R38_RS19345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4R38_RS19350	COG5006	permease, DMT superfamily
A4R38_RS19365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS19370	COG0765	amino acid transport
A4R38_RS19375	COG1126	abc transporter atp-binding protein
A4R38_RS19380	COG0668	transmembrane transport
A4R38_RS19400	COG3128	pkhd-type hydroxylase
A4R38_RS19405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4R38_RS19415	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS19420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4R38_RS19425	COG1199	ATP-dependent helicase activity
A4R38_RS19440	COG0513	Belongs to the DEAD box helicase family
A4R38_RS19445	COG1309	transcriptional regulator
A4R38_RS19455	COG1131	(ABC) transporter
A4R38_RS19460	COG0842	Transport permease protein
A4R38_RS19465	COG0842	Transport permease protein
A4R38_RS19475	COG3568	Endonuclease Exonuclease Phosphatase
A4R38_RS19480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS19485	COG0392	lysyltransferase activity
A4R38_RS19490	COG0670	Belongs to the BI1 family
A4R38_RS19495	COG0670	Belongs to the BI1 family
A4R38_RS19500	COG0314	molybdopterin synthase activity
A4R38_RS19505	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4R38_RS19515	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4R38_RS19525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4R38_RS19535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R38_RS19540	COG2226	methyltransferase
A4R38_RS19555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R38_RS19560	COG1881	PFAM PEBP family protein
A4R38_RS19565	COG4677	pectinesterase activity
A4R38_RS19570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R38_RS19575	COG0471	metal ion transport
A4R38_RS19580	COG2828	Protein conserved in bacteria
A4R38_RS19585	COG0583	DNA-binding transcription factor activity
A4R38_RS19595	COG0561	phosphatase activity
A4R38_RS19600	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4R38_RS19605	COG4149	molybdate abc transporter
A4R38_RS19610	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4R38_RS19620	COG3585	molybdate ion transport
A4R38_RS19620	COG2005	Transcriptional regulator
A4R38_RS19630	COG1119	ATPase activity
A4R38_RS19635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4R38_RS19640	COG1085	galactose-1-phosphate uridylyltransferase
A4R38_RS19650	COG2017	converts alpha-aldose to the beta-anomer
A4R38_RS19660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R38_RS19675	COG1230	cation diffusion facilitator family transporter
A4R38_RS19680	COG3201	nicotinamide mononucleotide transporter
A4R38_RS19685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4R38_RS19725	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A4R38_RS19730	COG2885	chlorophyll binding
A4R38_RS19740	COG3064	Membrane
A4R38_RS19745	COG0848	biopolymer transport protein
A4R38_RS19750	COG0811	peptide transport
A4R38_RS19755	COG0824	Thioesterase
A4R38_RS19760	COG3790	cyd operon protein YbgE
A4R38_RS19765	COG4890	Cyd operon protein YbgT
A4R38_RS19770	COG1294	oxidase, subunit
A4R38_RS19775	COG1271	oxidase subunit
A4R38_RS19790	COG0383	alpha-mannosidase activity
A4R38_RS19795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS19795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4R38_RS19795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS19800	COG2188	Transcriptional regulator
A4R38_RS19805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS19815	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R38_RS19820	COG0567	Dehydrogenase, E1 component
A4R38_RS19830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R38_RS19835	COG1053	succinate dehydrogenase
A4R38_RS19840	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A4R38_RS19845	COG2009	succinate dehydrogenase
A4R38_RS19855	COG0372	Belongs to the citrate synthase family
A4R38_RS19860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4R38_RS19870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4R38_RS19875	COG2721	sulfolactate sulfo-lyase activity
A4R38_RS19885	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS19890	COG1063	alcohol dehydrogenase
A4R38_RS19895	COG0473	3-isopropylmalate dehydrogenase activity
A4R38_RS19895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R38_RS19900	COG2186	Transcriptional regulator
A4R38_RS19905	COG3180	Ammonia monooxygenase
A4R38_RS19915	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4R38_RS19920	COG1984	allophanate hydrolase subunit 2
A4R38_RS19925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4R38_RS19930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4R38_RS19940	COG0415	Belongs to the DNA photolyase family
A4R38_RS19945	COG3272	Protein of unknown function (DUF1722)
A4R38_RS19975	COG2205	protein histidine kinase activity
A4R38_RS19980	COG0745	RESPONSE REGULATOR receiver
A4R38_RS19990	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS19995	COG0531	amino acid
A4R38_RS20000	COG0033	Phosphoglucomutase
A4R38_RS20005	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A4R38_RS20010	COG0596	Alpha beta hydrolase
A4R38_RS20020	COG0716	FMN binding
A4R38_RS20035	COG0735	belongs to the Fur family
A4R38_RS20055	COG1349	DNA-binding transcription factor activity
A4R38_RS20060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4R38_RS20065	COG3395	kinase activity
A4R38_RS20075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS20080	COG0861	Integral membrane protein TerC family
A4R38_RS20100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS20100	COG1263	PTS System
A4R38_RS20100	COG2190	(PTS) system
A4R38_RS20110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4R38_RS20115	COG1940	carbohydrate kinase activity
A4R38_RS20115	COG1846	Transcriptional regulator
A4R38_RS20120	COG0647	UMP catabolic process
A4R38_RS20125	COG0367	asparagine synthase
A4R38_RS20170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R38_RS20180	COG1702	phosphate starvation-inducible protein PhoH
A4R38_RS20190	COG4535	Mg2 and Co2 transporter CorC
A4R38_RS20195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4R38_RS20205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R38_RS20210	COG0765	amino acid transport
A4R38_RS20215	COG0765	amino acid transport
A4R38_RS20220	COG1126	abc transporter atp-binding protein
A4R38_RS20230	COG0443	Heat shock 70 kDa protein
A4R38_RS20235	COG2214	Heat shock protein DnaJ domain protein
A4R38_RS20245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A4R38_RS20255	COG2888	peptidyl-tyrosine sulfation
A4R38_RS20270	COG1466	dna polymerase III delta subunit
A4R38_RS20280	COG0406	alpha-ribazole phosphatase activity
A4R38_RS20285	COG0799	negative regulation of ribosome biogenesis
A4R38_RS20295	COG0768	penicillin binding
A4R38_RS20300	COG0772	Belongs to the SEDS family
A4R38_RS20305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4R38_RS20310	COG1686	Belongs to the peptidase S11 family
A4R38_RS20330	COG0583	DNA-binding transcription factor activity
A4R38_RS20340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R38_RS20345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R38_RS20365	COG3069	C4-dicarboxylate transmembrane transporter activity
A4R38_RS20370	COG4565	transcriptional regulatory protein
A4R38_RS20375	COG3290	protein histidine kinase activity
A4R38_RS20380	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A4R38_RS20390	COG2301	Belongs to the HpcH HpaI aldolase family
A4R38_RS20395	COG3051	citrate lyase alpha subunit
A4R38_RS20410	COG0471	metal ion transport
A4R38_RS20415	COG3719	Belongs to the RNase T2 family
A4R38_RS20420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R38_RS20425	COG0589	response to stress
A4R38_RS20430	COG3634	alkyl hydroperoxide reductase activity
A4R38_RS20435	COG0450	alkyl hydroperoxide reductase
A4R38_RS20440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R38_RS20445	COG0583	DNA-binding transcription factor activity
A4R38_RS20450	COG3969	phosphoadenosine phosphosulfate
A4R38_RS20455	COG1475	DNA binding
A4R38_RS20460	COG0436	Aminotransferase
A4R38_RS20465	COG0371	Dehydrogenase
A4R38_RS20470	COG2879	small protein
A4R38_RS20475	COG1966	Carbon starvation protein
A4R38_RS20480	COG2050	protein possibly involved in aromatic compounds catabolism
A4R38_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS20490	COG1535	isochorismatase
A4R38_RS20490	COG3433	isochorismatase activity
A4R38_RS20495	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4R38_RS20500	COG1169	isochorismate synthase
A4R38_RS20505	COG4592	Periplasmic binding protein
A4R38_RS20515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS20520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS20525	COG1120	ATPase activity
A4R38_RS20530	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A4R38_RS20535	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A4R38_RS20535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R38_RS20540	COG3251	PFAM MbtH domain protein
A4R38_RS20545	COG2382	esterase
A4R38_RS20550	COG4771	TonB-dependent receptor
A4R38_RS20560	COG2977	Belongs to the P-Pant transferase superfamily
A4R38_RS20565	COG3958	Transketolase
A4R38_RS20570	COG3959	Transketolase, thiamine diphosphate binding domain
A4R38_RS20575	COG2390	Transcriptional regulator
A4R38_RS20580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4R38_RS20585	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS20595	COG1129	ABC transporter
A4R38_RS20600	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS20625	COG2801	Transposase and inactivated derivatives
A4R38_RS20630	COG2963	transposase activity
A4R38_RS20650	COG2315	Protein conserved in bacteria
A4R38_RS20655	COG0778	Nitroreductase
A4R38_RS20660	COG0668	transmembrane transport
A4R38_RS20665	COG1113	amino acid transport
A4R38_RS20670	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS20675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS20680	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS20685	COG1538	Outer membrane efflux protein
A4R38_RS20690	COG0745	RESPONSE REGULATOR receiver
A4R38_RS20695	COG5002	protein histidine kinase activity
A4R38_RS20700	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS20705	COG4783	chaperone-mediated protein folding
A4R38_RS20715	COG4571	Outer membrane protease
A4R38_RS20720	COG0500	methyltransferase
A4R38_RS20725	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R38_RS20730	COG0582	viral genome integration into host DNA
A4R38_RS20750	COG2501	S4 domain
A4R38_RS20755	COG1988	membrane-bound metal-dependent
A4R38_RS20765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R38_RS20780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4R38_RS20785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4R38_RS20790	COG0549	Belongs to the carbamate kinase family
A4R38_RS20800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS20805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS20810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R38_RS20815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R38_RS20820	COG3257	ureidoglycine aminohydrolase activity
A4R38_RS20825	COG1929	Belongs to the glycerate kinase type-1 family
A4R38_RS20830	COG2233	PERMEase
A4R38_RS20840	COG1953	Uracil, thiamine, allantoin
A4R38_RS20850	COG3622	Belongs to the hyi family
A4R38_RS20855	COG3960	tartronate-semialdehyde synthase activity
A4R38_RS20900	COG3157	Type VI secretion system effector, Hcp
A4R38_RS20905	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A4R38_RS20910	COG4181	ATPase activity
A4R38_RS20915	COG2755	lipolytic protein G-D-S-L family
A4R38_RS20920	COG0300	oxidoreductase activity
A4R38_RS20925	COG3118	belongs to the thioredoxin family
A4R38_RS20930	COG0390	transport system, permease component
A4R38_RS20935	COG4619	ABC transporter
A4R38_RS20940	COG0330	HflC and HflK could
A4R38_RS20945	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4R38_RS20960	COG0789	Transcriptional regulator
A4R38_RS20965	COG0531	amino acid
A4R38_RS20970	COG2066	Belongs to the glutaminase family
A4R38_RS20975	COG2217	Heavy metal translocating P-type atpase
A4R38_RS20980	COG3093	addiction module antidote protein HigA
A4R38_RS20985	COG3549	Plasmid maintenance system killer
A4R38_RS20990	COG3735	TraB family
A4R38_RS20995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4R38_RS21010	COG0737	Belongs to the 5'-nucleotidase family
A4R38_RS21015	COG2223	nitrite transmembrane transporter activity
A4R38_RS21020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4R38_RS21020	COG4651	solute:proton antiporter activity
A4R38_RS21025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS21060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4R38_RS21070	COG2832	Protein of unknown function (DUF454)
A4R38_RS21075	COG3923	Primosomal replication protein n
A4R38_RS21085	COG3264	Mechanosensitive ion channel
A4R38_RS21085	COG1196	nuclear chromosome segregation
A4R38_RS21090	COG1309	transcriptional regulator
A4R38_RS21095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4R38_RS21100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R38_RS21115	COG0110	maltose O-acetyltransferase activity
A4R38_RS21125	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4R38_RS21130	COG5507	3-demethylubiquinone-9 3-methyltransferase
A4R38_RS21140	COG3695	enzyme binding
A4R38_RS21145	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A4R38_RS21150	COG1946	Acyl-CoA thioesterase
A4R38_RS21155	COG0004	ammonium transporteR
A4R38_RS21160	COG0347	Belongs to the P(II) protein family
A4R38_RS21165	COG1132	(ABC) transporter
A4R38_RS21170	COG1132	(ABC) transporter
A4R38_RS21175	COG1522	sequence-specific DNA binding
A4R38_RS21185	COG4533	DNA binding
A4R38_RS21195	COG0824	Thioesterase
A4R38_RS21200	COG1555	photosystem II stabilization
A4R38_RS21205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R38_RS21210	COG0776	regulation of translation
A4R38_RS21215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4R38_RS21240	COG0271	Belongs to the BolA IbaG family
A4R38_RS21245	COG3056	Lipoprotein
A4R38_RS21250	COG2223	nitrite transmembrane transporter activity
A4R38_RS21255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4R38_RS21260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4R38_RS21265	COG1845	cytochrome c oxidase, subunit III
A4R38_RS21270	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4R38_RS21280	COG2814	Major facilitator Superfamily
A4R38_RS21290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4R38_RS21295	COG0693	protein deglycase activity
A4R38_RS21310	COG0142	geranyltranstransferase activity
A4R38_RS21320	COG0667	Aldo Keto reductase
A4R38_RS21325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4R38_RS21330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4R38_RS21345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R38_RS21345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R38_RS21355	COG4238	major outer membrane lipoprotein
A4R38_RS21360	COG3248	Nucleoside-binding outer membrane protein
A4R38_RS21365	COG1403	HNH endonuclease
A4R38_RS21370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R38_RS21375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R38_RS21380	COG1862	Preprotein translocase
A4R38_RS21400	COG0366	Alpha amylase catalytic
A4R38_RS21405	COG1113	amino acid transport
A4R38_RS21410	COG1114	Component of the transport system for branched-chain amino acids
A4R38_RS21415	COG5002	protein histidine kinase activity
A4R38_RS21420	COG0745	RESPONSE REGULATOR receiver
A4R38_RS21425	COG0420	3'-5' exonuclease activity
A4R38_RS21430	COG0419	ATPase involved in DNA repair
A4R38_RS21435	COG2814	Major facilitator Superfamily
A4R38_RS21440	COG1940	carbohydrate kinase activity
A4R38_RS21460	COG4126	flavin adenine dinucleotide binding
A4R38_RS21485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4R38_RS21490	COG3706	GGDEF domain
A4R38_RS21500	COG1785	Belongs to the alkaline phosphatase family
A4R38_RS21510	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R38_RS21530	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A4R38_RS21540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R38_RS21545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R38_RS21550	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS21555	COG0113	porphobilinogen synthase activity
A4R38_RS21560	COG2175	clavaminate synthase activity
A4R38_RS21565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R38_RS21575	COG4521	taurine ABC transporter
A4R38_RS21595	COG3122	Protein conserved in bacteria
A4R38_RS21600	COG2814	Major facilitator Superfamily
A4R38_RS21605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R38_RS21635	COG1414	Transcriptional regulator
A4R38_RS21640	COG1609	Transcriptional regulator
A4R38_RS21650	COG2223	nitrite transmembrane transporter activity
A4R38_RS21655	COG0110	maltose O-acetyltransferase activity
A4R38_RS21660	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS21665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4R38_RS21670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R38_RS21675	COG2079	MmgE PrpD family protein
A4R38_RS21680	COG0372	Belongs to the citrate synthase family
A4R38_RS21685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4R38_RS21700	COG1280	lysine exporter protein (LysE YggA)
A4R38_RS21705	COG1064	alcohol dehydrogenase
A4R38_RS21710	COG0402	S-adenosylhomocysteine deaminase activity
A4R38_RS21715	COG0549	Belongs to the carbamate kinase family
A4R38_RS21720	COG1304	FMN binding
A4R38_RS21725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4R38_RS21735	COG0666	response to abiotic stimulus
A4R38_RS21745	COG0583	DNA-binding transcription factor activity
A4R38_RS21750	COG2771	luxR family
A4R38_RS21750	COG2200	EAL domain
A4R38_RS21760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4R38_RS21770	COG1012	belongs to the aldehyde dehydrogenase family
A4R38_RS21785	COG0582	viral genome integration into host DNA
A4R38_RS21790	COG2200	EAL domain
A4R38_RS21790	COG2771	luxR family
A4R38_RS21815	COG1556	Lactate utilization protein
A4R38_RS21820	COG1139	Iron-sulfur cluster binding protein
A4R38_RS21825	COG0247	lactate metabolic process
A4R38_RS21830	COG2207	Transcriptional regulator
A4R38_RS21835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS21845	COG3059	membrane
A4R38_RS21850	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS21855	COG2207	Transcriptional regulator
A4R38_RS21855	COG3708	Transcriptional regulator
A4R38_RS21860	COG4932	domain protein
A4R38_RS21860	COG2373	Large extracellular alpha-helical protein
A4R38_RS21860	COG1388	LysM domain
A4R38_RS21865	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS21870	COG0667	Aldo Keto reductase
A4R38_RS21880	COG0583	DNA-binding transcription factor activity
A4R38_RS21885	COG1073	alpha beta
A4R38_RS21890	COG1902	pentaerythritol trinitrate reductase activity
A4R38_RS21940	COG0727	PFAM Uncharacterised protein family (UPF0153)
A4R38_RS21945	COG3477	response to acidic pH
A4R38_RS21960	COG4974	Belongs to the 'phage' integrase family
A4R38_RS21985	COG0732	type I restriction modification DNA specificity domain
A4R38_RS22010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4R38_RS22030	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4R38_RS22035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R38_RS22040	COG1690	Belongs to the RtcB family
A4R38_RS22045	COG0454	-acetyltransferase
A4R38_RS22065	COG1943	Transposase
A4R38_RS22070	COG0791	NLP P60 protein
A4R38_RS22075	COG3034	peptidoglycan biosynthetic process
A4R38_RS22080	COG0121	glutamine amidotransferase
A4R38_RS22090	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS22100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R38_RS22110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4R38_RS22120	COG2226	methyltransferase
A4R38_RS22130	COG1388	LysM domain
A4R38_RS22130	COG0741	lytic transglycosylase activity
A4R38_RS22135	COG2226	methyltransferase
A4R38_RS22145	COG0583	DNA-binding transcription factor activity
A4R38_RS22150	COG0656	L-ascorbic acid biosynthetic process
A4R38_RS22185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4R38_RS22190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4R38_RS22195	COG2011	ABC-type metal ion transport system permease component
A4R38_RS22200	COG1464	Belongs to the NlpA lipoprotein family
A4R38_RS22210	COG1720	tRNA m6t6A37 methyltransferase activity
A4R38_RS22220	COG0791	NLP P60 protein
A4R38_RS22225	COG3015	lipoprotein NlpE involved in copper resistance
A4R38_RS22230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R38_RS22235	COG4681	YaeQ
A4R38_RS22245	COG4568	rho-dependent transcription termination
A4R38_RS22250	COG0037	tRNA processing
A4R38_RS22255	COG0346	lactoylglutathione lyase activity
A4R38_RS22260	COG1982	Orn Lys Arg decarboxylase major
A4R38_RS22270	COG0587	DNA-directed DNA polymerase activity
A4R38_RS22295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4R38_RS22300	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A4R38_RS22310	COG0750	zinc metalloprotease
A4R38_RS22315	COG0575	Belongs to the CDS family
A4R38_RS22320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4R38_RS22325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4R38_RS22350	COG0024	Methionine aminopeptidase
A4R38_RS22370	COG3835	regulator
A4R38_RS22375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R38_RS22390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R38_RS22395	COG2860	membrane
A4R38_RS22415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R38_RS22420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R38_RS22425	COG1120	ATPase activity
A4R38_RS22430	COG4774	siderophore transport
A4R38_RS22445	COG3121	Chaperone
A4R38_RS22455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4R38_RS22460	COG1643	Atp-dependent helicase
A4R38_RS22465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A4R38_RS22475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4R38_RS22480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4R38_RS22485	COG0617	tRNA 3'-terminal CCA addition
A4R38_RS22490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4R38_RS22495	COG3539	Fimbrial protein
A4R38_RS22500	COG3121	Chaperone
A4R38_RS22505	COG3188	usher protein
A4R38_RS22510	COG3539	Fimbrial protein
A4R38_RS22515	COG3539	Fimbrial protein
A4R38_RS22520	COG3539	Fimbrial protein
A4R38_RS22525	COG3539	Fimbrial protein
A4R38_RS22535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4R38_RS22540	COG5464	transposase or invertase
A4R38_RS22545	COG5464	transposase or invertase
A4R38_RS22555	COG0726	polysaccharide deacetylase
A4R38_RS22560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS22565	COG0842	Transport permease protein
A4R38_RS22570	COG1131	(ABC) transporter
A4R38_RS22575	COG0288	reversible hydration of carbon dioxide
A4R38_RS22580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A4R38_RS22585	COG4993	Dehydrogenase
A4R38_RS22590	COG2132	Multicopper oxidase
A4R38_RS22615	COG1049	propionate catabolic process, 2-methylcitrate cycle
A4R38_RS22620	COG3064	Membrane
A4R38_RS22620	COG3064	Membrane
A4R38_RS22625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R38_RS22630	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R38_RS22635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4R38_RS22640	COG2186	Transcriptional regulator
A4R38_RS22680	COG3157	Type VI secretion system effector, Hcp
A4R38_RS22685	COG1113	amino acid transport
A4R38_RS22690	COG3725	Membrane protein required for beta-lactamase induction
A4R38_RS22695	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4R38_RS22700	COG0157	Belongs to the NadC ModD family
A4R38_RS22710	COG4969	Belongs to the N-Me-Phe pilin family
A4R38_RS22715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4R38_RS22720	COG1459	type II secretion system
A4R38_RS22730	COG0237	dephospho-CoA kinase activity
A4R38_RS22745	COG0494	nUDIX hydrolase
A4R38_RS22765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4R38_RS22770	COG0849	cell division
A4R38_RS22775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4R38_RS22780	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R38_RS22795	COG0772	Belongs to the SEDS family
A4R38_RS22810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4R38_RS22815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4R38_RS22820	COG0768	penicillin binding
A4R38_RS22825	COG3116	cell division
A4R38_RS22840	COG1609	Transcriptional regulator
A4R38_RS22850	COG0440	acetolactate synthase activity
A4R38_RS22855	COG0028	Belongs to the TPP enzyme family
A4R38_RS22860	COG0583	DNA-binding transcription factor activity
A4R38_RS22900	COG4143	(ABC) transporter
A4R38_RS22905	COG1178	ABC-type Fe3 transport system permease component
A4R38_RS22915	COG0586	Pfam SNARE associated Golgi protein
A4R38_RS22930	COG3181	Tripartite tricarboxylate transporter family receptor
A4R38_RS22935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS22940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R38_RS22945	COG4977	sequence-specific DNA binding
A4R38_RS22960	COG0235	Class ii aldolase
A4R38_RS22965	COG0417	DNA replication proofreading
A4R38_RS22975	COG0564	pseudouridine synthase activity
A4R38_RS22980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4R38_RS22990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R38_RS22995	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4R38_RS23025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4R38_RS23040	COG2271	Major facilitator Superfamily
A4R38_RS23045	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4R38_RS23050	COG0644	oxidoreductase
A4R38_RS23105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4R38_RS23110	COG0505	Belongs to the CarA family
A4R38_RS23145	COG1047	Peptidyl-prolyl cis-trans
A4R38_RS23160	COG0196	riboflavin kinase activity
A4R38_RS23185	COG0583	DNA-binding transcription factor activity
A4R38_RS23200	COG3119	arylsulfatase activity
A4R38_RS23210	COG1662	PFAM IS1 transposase
A4R38_RS23240	COG4735	regulation of single-species biofilm formation
A4R38_RS23245	COG1584	GPR1 FUN34 yaaH family protein
A4R38_RS23250	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4R38_RS23260	COG1115	amino acid carrier protein
A4R38_RS23280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4R38_RS23290	COG0460	homoserine dehydrogenase
A4R38_RS23290	COG0527	aspartate kinase activity
A4R38_RS23300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A4R38_RS23310	COG0745	RESPONSE REGULATOR receiver
A4R38_RS23315	COG4452	Inner membrane protein CreD
A4R38_RS23320	COG2205	protein histidine kinase activity
A4R38_RS23325	COG0745	RESPONSE REGULATOR receiver
A4R38_RS23330	COG3045	CreA protein
A4R38_RS23335	COG3708	Transcriptional regulator
A4R38_RS23335	COG2207	Transcriptional regulator
A4R38_RS23355	COG0741	lytic transglycosylase activity
A4R38_RS23360	COG0488	(ABC) transporter
A4R38_RS23370	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A4R38_RS23375	COG3172	ATPase kinase involved in NAD metabolism
A4R38_RS23375	COG1056	cytidyltransferase-related domain
A4R38_RS23380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4R38_RS23385	COG0560	Phosphoserine phosphatase
A4R38_RS23390	COG3726	membrane protein affecting hemolysin expression
A4R38_RS23430	COG1328	CTP reductase activity
A4R38_RS23435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4R38_RS23440	COG0084	hydrolase, TatD family'
A4R38_RS23445	COG4667	esterase of the alpha-beta hydrolase superfamily
A4R38_RS23455	COG2823	Periplasmic or secreted lipoprotein
A4R38_RS23465	COG1011	Hydrolase
A4R38_RS23470	COG0456	acetyltransferase
A4R38_RS23475	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A4R38_RS23510	COG4114	ferric iron reductase
A4R38_RS23515	COG2197	response regulator
A4R38_RS23520	COG2197	response regulator
A4R38_RS23525	COG2966	Psort location CytoplasmicMembrane, score
A4R38_RS23540	COG1484	DNA-dependent DNA replication
A4R38_RS23555	COG1063	alcohol dehydrogenase
A4R38_RS23560	COG1802	Transcriptional regulator
A4R38_RS23565	COG2271	Major facilitator Superfamily
A4R38_RS23570	COG0840	transmembrane signaling receptor activity
A4R38_RS23580	COG1966	Carbon starvation protein
A4R38_RS23585	COG2879	small protein
A4R38_RS23590	COG0523	cobalamin synthesis protein
A4R38_RS23615	COG2814	Major facilitator Superfamily
A4R38_RS23620	COG2733	membrane
A4R38_RS23625	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
A4R38_RS23630	COG1924	4 iron, 4 sulfur cluster binding
A4R38_RS23645	COG0477	Major facilitator Superfamily
A4R38_RS23655	COG3366	ferrous iron transmembrane transporter activity
A4R38_RS23660	COG0700	Nucleoside recognition
A4R38_RS23665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4R38_RS23670	COG0583	DNA-binding transcription factor activity
A4R38_RS23695	COG2186	Transcriptional regulator
A4R38_RS23705	COG0246	Mannitol dehydrogenase
A4R38_RS23720	COG2610	gluconate transmembrane transporter activity
A4R38_RS23725	COG3539	Fimbrial protein
A4R38_RS23730	COG3539	Fimbrial protein
A4R38_RS23735	COG3539	Fimbrial protein
A4R38_RS23740	COG3188	usher protein
A4R38_RS23745	COG3121	Chaperone
A4R38_RS23750	COG3539	Fimbrial protein
A4R38_RS23765	COG4974	Belongs to the 'phage' integrase family
A4R38_RS23770	COG0582	viral genome integration into host DNA
A4R38_RS23785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A4R38_RS23790	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A4R38_RS23800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS23800	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4R38_RS23810	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS23815	COG4372	Transposase
A4R38_RS23820	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4R38_RS23820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4R38_RS23835	COG3153	acetyltransferase
A4R38_RS23840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4R38_RS23850	COG1363	Peptidase, m42
A4R38_RS23855	COG3414	Phosphotransferase system galactitol-specific IIB component
A4R38_RS23860	COG3775	system Galactitol-specific IIC component
A4R38_RS23865	COG0434	BtpA family
A4R38_RS23870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS23875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4R38_RS23880	COG1349	DNA-binding transcription factor activity
A4R38_RS23885	COG1414	Transcriptional regulator
A4R38_RS23890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R38_RS23895	COG0129	dihydroxy-acid dehydratase activity
A4R38_RS23900	COG2610	gluconate transmembrane transporter activity
A4R38_RS23910	COG2390	Transcriptional regulator
A4R38_RS23935	COG1215	transferase activity, transferring glycosyl groups
A4R38_RS23940	COG1401	restriction endodeoxyribonuclease activity
A4R38_RS24000	COG2003	Belongs to the UPF0758 family
A4R38_RS24025	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS24030	COG4584	PFAM Integrase catalytic
A4R38_RS24035	COG1484	DNA-dependent DNA replication
A4R38_RS24040	COG3468	outer membrane autotransporter barrel domain protein
A4R38_RS24110	COG3436	PFAM IS66 Orf2 family protein
A4R38_RS24115	COG4372	Transposase
A4R38_RS24125	COG0440	acetolactate synthase activity
A4R38_RS24130	COG0440	acetolactate synthase activity
A4R38_RS24135	COG1349	DNA-binding transcription factor activity
A4R38_RS24145	COG0738	Major facilitator superfamily
A4R38_RS24160	COG3037	sugar-specific permease SgaT UlaA
A4R38_RS24170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R38_RS24200	COG1289	transmembrane transporter activity
A4R38_RS24210	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4R38_RS24215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS24215	COG1263	PTS System
A4R38_RS24215	COG2190	(PTS) system
A4R38_RS24220	COG1737	Transcriptional regulator
A4R38_RS24245	COG3177	Filamentation induced by cAMP protein fic
A4R38_RS24260	COG3335	DDE superfamily endonuclease
A4R38_RS24275	COG2205	protein histidine kinase activity
A4R38_RS24295	COG4227	nucleotidyltransferase activity
A4R38_RS24320	COG1064	alcohol dehydrogenase
A4R38_RS24325	COG3265	gluconokinase activity
A4R38_RS24330	COG1063	alcohol dehydrogenase
A4R38_RS24335	COG1028	Short-chain dehydrogenase reductase Sdr
A4R38_RS24340	COG2610	gluconate transmembrane transporter activity
A4R38_RS24345	COG1609	Transcriptional regulator
A4R38_RS24355	COG0795	lipopolysaccharide-transporting ATPase activity
A4R38_RS24360	COG0795	lipopolysaccharide-transporting ATPase activity
A4R38_RS24370	COG2927	DNA polymerase III (CHI subunit)
A4R38_RS24375	COG0525	valine-tRNA ligase activity
A4R38_RS24385	COG0456	acetyltransferase
A4R38_RS24390	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A4R38_RS24395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4R38_RS24400	COG2731	YhcH YjgK YiaL family protein
A4R38_RS24410	COG0549	Belongs to the carbamate kinase family
A4R38_RS24415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4R38_RS24420	COG1288	antiporter activity
A4R38_RS24425	COG1438	arginine binding
A4R38_RS24445	COG0251	oxidation-reduction process
A4R38_RS24450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4R38_RS24455	COG1609	Transcriptional regulator
A4R38_RS24460	COG1263	PTS System
A4R38_RS24460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R38_RS24465	COG0366	Alpha amylase catalytic
A4R38_RS24475	COG1328	CTP reductase activity
A4R38_RS24480	COG0602	queuosine metabolic process
A4R38_RS24485	COG3783	Cytochrome b(562)
A4R38_RS24490	COG0312	modulator of DNA gyrase
A4R38_RS24500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4R38_RS24510	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS24515	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R38_RS24520	COG1129	ABC transporter
A4R38_RS24525	COG1879	ABC-type sugar transport system periplasmic component
A4R38_RS24530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4R38_RS24535	COG2105	PFAM AIG2 family protein
A4R38_RS24540	COG2911	Protein conserved in bacteria
A4R38_RS24545	COG0729	surface antigen
A4R38_RS24560	COG1253	flavin adenine dinucleotide binding
A4R38_RS24570	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A4R38_RS24575	COG1218	3'(2'),5'-bisphosphate nucleotidase
A4R38_RS24580	COG0737	Belongs to the 5'-nucleotidase family
A4R38_RS24585	COG1733	regulation of RNA biosynthetic process
A4R38_RS24590	COG0702	epimerase
A4R38_RS24595	COG0697	spore germination
A4R38_RS24605	COG1113	amino acid transport
A4R38_RS24610	COG0545	Peptidyl-prolyl cis-trans isomerase
A4R38_RS24615	COG3061	Opacity-associated protein A
A4R38_RS24620	COG1309	transcriptional regulator
A4R38_RS24635	COG1024	Enoyl-CoA hydratase
A4R38_RS24640	COG4670	ketone body catabolic process
A4R38_RS24645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4R38_RS24650	COG2271	Major facilitator Superfamily
A4R38_RS24670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4R38_RS24780	COG1960	acyl-CoA dehydrogenase activity
A4R38_RS24830	COG0557	exoribonuclease II activity
A4R38_RS24900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4R38_RS24900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4R38_RS25095	COG3710	Transcriptional regulator