locus-tag	class	description
I6J81_RS00010	COG1881	PFAM PEBP family protein
I6J81_RS00020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J81_RS00035	COG2226	methyltransferase
I6J81_RS00040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J81_RS00050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J81_RS00060	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J81_RS00070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6J81_RS00075	COG0314	molybdopterin synthase activity
I6J81_RS00080	COG0670	Belongs to the BI1 family
I6J81_RS00085	COG0670	Belongs to the BI1 family
I6J81_RS00090	COG0392	lysyltransferase activity
I6J81_RS00095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J81_RS00100	COG3568	Endonuclease Exonuclease Phosphatase
I6J81_RS00110	COG0842	Transport permease protein
I6J81_RS00115	COG0842	Transport permease protein
I6J81_RS00120	COG1131	(ABC) transporter
I6J81_RS00130	COG1309	transcriptional regulator
I6J81_RS00135	COG0513	Belongs to the DEAD box helicase family
I6J81_RS00145	COG1199	ATP-dependent helicase activity
I6J81_RS00150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J81_RS00155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J81_RS00165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J81_RS00190	COG0668	transmembrane transport
I6J81_RS00195	COG1126	abc transporter atp-binding protein
I6J81_RS00200	COG0765	amino acid transport
I6J81_RS00205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS00215	COG5006	permease, DMT superfamily
I6J81_RS00225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J81_RS00230	COG2194	sulfuric ester hydrolase activity
I6J81_RS00240	COG1321	iron dependent repressor
I6J81_RS00245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J81_RS00250	COG1376	ErfK ybiS ycfS ynhG family protein
I6J81_RS00255	COG0488	(ABC) transporter
I6J81_RS00260	COG0561	phosphatase activity
I6J81_RS00265	COG1882	Formate acetyltransferase
I6J81_RS00270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J81_RS00275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J81_RS00280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J81_RS00285	COG0303	'Molybdopterin
I6J81_RS00290	COG1446	asparaginase
I6J81_RS00315	COG2200	EAL domain
I6J81_RS00320	COG2199	diguanylate cyclase activity
I6J81_RS00335	COG2133	pyrroloquinoline quinone binding
I6J81_RS00340	COG0625	glutathione transferase activity
I6J81_RS00345	COG1686	Belongs to the peptidase S11 family
I6J81_RS00350	COG1349	DNA-binding transcription factor activity
I6J81_RS00355	COG0671	phosphoesterase, PA-phosphatase related
I6J81_RS00360	COG2814	Major facilitator Superfamily
I6J81_RS00370	COG0561	phosphatase activity
I6J81_RS00375	COG0738	Major facilitator superfamily
I6J81_RS00380	COG3226	Transcriptional regulator
I6J81_RS00385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J81_RS00440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J81_RS00475	COG4695	Portal protein
I6J81_RS00570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J81_RS00625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J81_RS00635	COG0778	Nitroreductase
I6J81_RS00650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J81_RS00655	COG3842	ATPase activity
I6J81_RS00660	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J81_RS00665	COG1177	transmembrane transport
I6J81_RS00680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS00685	COG4160	amino acid transport
I6J81_RS00690	COG4215	(ABC) transporter
I6J81_RS00695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS00700	COG1126	abc transporter atp-binding protein
I6J81_RS00715	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J81_RS00720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J81_RS00725	COG0702	epimerase
I6J81_RS00730	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6J81_RS00735	COG0028	Belongs to the TPP enzyme family
I6J81_RS00740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J81_RS00745	COG1151	hydroxylamine reductase activity
I6J81_RS00750	COG2431	L-lysine efflux transmembrane transporter activity
I6J81_RS00760	COG3593	DNA synthesis involved in DNA repair
I6J81_RS00765	COG2990	Protein conserved in bacteria
I6J81_RS00770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS00780	COG1278	Cold shock
I6J81_RS00790	COG0542	response to heat
I6J81_RS00795	COG1518	maintenance of DNA repeat elements
I6J81_RS00800	COG1203	CRISPR-associated helicase, Cas3
I6J81_RS00840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J81_RS00845	COG4988	ABC transporter
I6J81_RS00850	COG0492	ferredoxin-NADP+ reductase activity
I6J81_RS00855	COG1522	sequence-specific DNA binding
I6J81_RS00860	COG1674	ftsk spoiiie
I6J81_RS00860	COG1178	ABC-type Fe3 transport system permease component
I6J81_RS00870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J81_RS00880	COG0243	molybdopterin cofactor binding
I6J81_RS00885	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS00890	COG3302	dmso reductase anchor subunit
I6J81_RS00895	COG1335	isochorismatase
I6J81_RS00905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J81_RS00910	COG1882	Formate acetyltransferase
I6J81_RS00915	COG2116	formate transmembrane transporter activity
I6J81_RS00920	COG1944	ATP diphosphatase activity
I6J81_RS00925	COG2323	membrane
I6J81_RS00940	COG0501	Belongs to the peptidase M48B family
I6J81_RS00950	COG0539	negative regulation of cytoplasmic translation
I6J81_RS00960	COG2333	competence protein COMEC
I6J81_RS00960	COG0658	competence protein
I6J81_RS00975	COG3214	Protein conserved in bacteria
I6J81_RS00990	COG3173	Aminoglycoside phosphotransferase
I6J81_RS00995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J81_RS01000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J81_RS01010	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6J81_RS01020	COG2989	Protein conserved in bacteria
I6J81_RS01025	COG3108	Peptidase M15
I6J81_RS01030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J81_RS01035	COG1448	Aminotransferase
I6J81_RS01055	COG0308	aminopeptidase N
I6J81_RS01060	COG1116	anion transmembrane transporter activity
I6J81_RS01065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J81_RS01075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J81_RS01080	COG0431	NADPH-dependent FMN reductase
I6J81_RS01095	COG0633	Ferredoxin
I6J81_RS01095	COG3217	Mosc domain protein beta barrel domain protein
I6J81_RS01100	COG0116	Belongs to the methyltransferase superfamily
I6J81_RS01100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J81_RS01105	COG0488	(ABC) transporter
I6J81_RS01110	COG2995	paraquat-inducible protein a
I6J81_RS01115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J81_RS01115	COG3008	intermembrane lipid transfer
I6J81_RS01120	COG3009	Protein conserved in bacteria
I6J81_RS01125	COG3130	regulation of translation
I6J81_RS01135	COG1067	ATP-dependent peptidase activity
I6J81_RS01145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J81_RS01145	COG2885	chlorophyll binding
I6J81_RS01155	COG3070	regulator of competence-specific genes
I6J81_RS01160	COG1289	transmembrane transporter activity
I6J81_RS01165	COG3304	Inner membrane component domain
I6J81_RS01170	COG0210	DNA helicase
I6J81_RS01185	COG1832	CoA-binding protein
I6J81_RS01205	COG2920	part of a sulfur-relay system
I6J81_RS01210	COG0670	Belongs to the BI1 family
I6J81_RS01220	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6J81_RS01225	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J81_RS01230	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6J81_RS01235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J81_RS01240	COG1999	signal sequence binding
I6J81_RS01245	COG1773	rubredoxin
I6J81_RS01250	COG1271	oxidase subunit
I6J81_RS01255	COG1294	oxidase, subunit
I6J81_RS01270	COG1278	Cold shock
I6J81_RS01275	COG1278	Cold shock
I6J81_RS01295	COG0348	domain, Protein
I6J81_RS01300	COG2205	protein histidine kinase activity
I6J81_RS01300	COG2198	Histidine kinase
I6J81_RS01300	COG0784	Response regulator, receiver
I6J81_RS01305	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS01310	COG0745	RESPONSE REGULATOR receiver
I6J81_RS01315	COG3005	denitrification pathway
I6J81_RS01320	COG0243	molybdopterin cofactor binding
I6J81_RS01325	COG3381	protein complex oligomerization
I6J81_RS01355	COG3729	General stress protein
I6J81_RS01360	COG2233	PERMEase
I6J81_RS01395	COG1309	transcriptional regulator
I6J81_RS01400	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J81_RS01400	COG0506	proline dehydrogenase activity
I6J81_RS01400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J81_RS01410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J81_RS01430	COG1702	phosphate starvation-inducible protein PhoH
I6J81_RS01435	COG3658	cytochrome
I6J81_RS01440	COG1215	transferase activity, transferring glycosyl groups
I6J81_RS01445	COG1649	PFAM Uncharacterised BCR, COG1649
I6J81_RS01445	COG0726	polysaccharide deacetylase
I6J81_RS01455	COG3706	GGDEF domain
I6J81_RS01460	COG0582	viral genome integration into host DNA
I6J81_RS01485	COG4983	Phage plasmid primase, P4 family domain protein
I6J81_RS01510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J81_RS01520	COG2222	sugar isomerase
I6J81_RS01560	COG3539	Fimbrial protein
I6J81_RS01605	COG2819	hydrolase of the alpha beta superfamily
I6J81_RS01610	COG2382	esterase
I6J81_RS01655	COG4771	TonB-dependent receptor
I6J81_RS01665	COG0523	cobalamin synthesis protein
I6J81_RS01710	COG3468	outer membrane autotransporter barrel domain protein
I6J81_RS01725	COG2003	Belongs to the UPF0758 family
I6J81_RS01780	COG3381	protein complex oligomerization
I6J81_RS01790	COG1462	curli production assembly transport component CsgG
I6J81_RS01805	COG2197	response regulator
I6J81_RS01830	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J81_RS01835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J81_RS01850	COG2943	transferase activity, transferring hexosyl groups
I6J81_RS01855	COG5645	(Lipo)protein
I6J81_RS01870	COG1560	Kdo2-lipid A biosynthetic process
I6J81_RS01880	COG2353	YceI-like domain
I6J81_RS01885	COG3038	cytochrome b561
I6J81_RS01895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J81_RS01920	COG2999	glutathione oxidoreductase activity
I6J81_RS01930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J81_RS01940	COG0673	inositol 2-dehydrogenase activity
I6J81_RS01945	COG0728	peptidoglycan biosynthetic process
I6J81_RS01950	COG3418	PFAM FlgN family protein
I6J81_RS01955	COG2747	anti-sigma28 factor FlgM
I6J81_RS01960	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6J81_RS01965	COG1815	bacterial-type flagellum-dependent cell motility
I6J81_RS01970	COG1558	bacterial-type flagellum-dependent cell motility
I6J81_RS01975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6J81_RS01980	COG1749	Flagellar hook protein flgE
I6J81_RS01985	COG4787	bacterial-type flagellum-dependent cell motility
I6J81_RS01990	COG4786	Flagellar basal body rod
I6J81_RS02005	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6J81_RS02005	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J81_RS02010	COG1256	bacterial-type flagellum assembly
I6J81_RS02015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J81_RS02020	COG1530	ribonuclease E activity
I6J81_RS02025	COG0564	pseudouridine synthase activity
I6J81_RS02030	COG0424	maF-like protein
I6J81_RS02035	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J81_RS02055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J81_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS02070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J81_RS02075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J81_RS02080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J81_RS02090	COG0470	DNA polymerase III
I6J81_RS02095	COG0084	hydrolase, TatD family'
I6J81_RS02100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS02100	COG1263	PTS System
I6J81_RS02105	COG4773	Receptor
I6J81_RS02110	COG0537	adenosine 5'-monophosphoramidase activity
I6J81_RS02115	COG5633	Lipoprotein
I6J81_RS02120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6J81_RS02140	COG1252	NADH dehydrogenase
I6J81_RS02145	COG3134	Outer membrane lipoprotein
I6J81_RS02150	COG1309	transcriptional regulator
I6J81_RS02160	COG1376	ErfK ybiS ycfS ynhG family protein
I6J81_RS02160	COG1388	LysM domain
I6J81_RS02165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J81_RS02170	COG4763	Acyl-transferase
I6J81_RS02175	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J81_RS02185	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J81_RS02195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J81_RS02200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J81_RS02210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J81_RS02215	COG1177	transmembrane transport
I6J81_RS02235	COG2850	peptidyl-arginine hydroxylation
I6J81_RS02240	COG2205	protein histidine kinase activity
I6J81_RS02250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J81_RS02270	COG1187	pseudouridine synthase activity
I6J81_RS02275	COG0538	isocitrate dehydrogenase activity
I6J81_RS02280	COG0582	viral genome integration into host DNA
I6J81_RS02445	COG3772	lysozyme
I6J81_RS02475	COG4220	transposase activity
I6J81_RS02495	COG1030	water channel activity
I6J81_RS02545	COG1196	nuclear chromosome segregation
I6J81_RS02580	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6J81_RS02595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J81_RS02600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J81_RS02605	COG1121	(ABC) transporter
I6J81_RS02620	COG0538	isocitrate dehydrogenase activity
I6J81_RS02630	COG5562	phage envelope protein
I6J81_RS02635	COG0789	Transcriptional regulator
I6J81_RS02640	COG2200	EAL domain
I6J81_RS02720	COG2894	cell division
I6J81_RS02745	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J81_RS02760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J81_RS02765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J81_RS02775	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J81_RS02785	COG2719	SpoVR family
I6J81_RS02795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J81_RS02805	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J81_RS02815	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6J81_RS02830	COG0157	Belongs to the NadC ModD family
I6J81_RS02835	COG0500	methyltransferase
I6J81_RS02840	COG1120	ATPase activity
I6J81_RS02845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS02850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J81_RS02860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J81_RS02860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J81_RS02860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS02865	COG1461	Dihydroxyacetone kinase
I6J81_RS02870	COG2376	Dihydroxyacetone kinase
I6J81_RS02875	COG3284	Transcriptional regulator
I6J81_RS02900	COG3039	Transposase
I6J81_RS02935	COG3423	Transcriptional regulator
I6J81_RS02950	COG2003	Belongs to the UPF0758 family
I6J81_RS02970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J81_RS02990	COG5290	Psort location Cytoplasmic, score
I6J81_RS03030	COG2826	transposase and inactivated derivatives, IS30 family
I6J81_RS03040	COG0582	viral genome integration into host DNA
I6J81_RS03045	COG0012	GTP binding
I6J81_RS03060	COG0659	secondary active sulfate transmembrane transporter activity
I6J81_RS03065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J81_RS03070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J81_RS03090	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J81_RS03095	COG3094	Invasion gene expression up-regulator, SirB
I6J81_RS03100	COG2912	Transglutaminase-like superfamily
I6J81_RS03115	COG0387	Pfam Sodium calcium exchanger
I6J81_RS03120	COG4572	Cation transport regulator
I6J81_RS03125	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6J81_RS03130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6J81_RS03135	COG4932	domain protein
I6J81_RS03140	COG2197	response regulator
I6J81_RS03145	COG3850	Histidine kinase
I6J81_RS03150	COG2223	nitrite transmembrane transporter activity
I6J81_RS03155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J81_RS03160	COG1140	nitrate reductase beta subunit
I6J81_RS03165	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J81_RS03170	COG2181	nitrate reductase activity
I6J81_RS03195	COG0788	formyltetrahydrofolate deformylase activity
I6J81_RS03205	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J81_RS03210	COG0745	RESPONSE REGULATOR receiver
I6J81_RS03215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J81_RS03225	COG1435	thymidine kinase activity
I6J81_RS03235	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS03235	COG1454	alcohol dehydrogenase
I6J81_RS03240	COG2095	MarC family integral membrane protein
I6J81_RS03245	COG4166	transmembrane transport
I6J81_RS03250	COG0601	transmembrane transport
I6J81_RS03255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J81_RS03260	COG0444	Belongs to the ABC transporter superfamily
I6J81_RS03265	COG4608	Belongs to the ABC transporter superfamily
I6J81_RS03285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J81_RS03290	COG2350	Protein conserved in bacteria
I6J81_RS03295	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6J81_RS03300	COG1607	acyl-coa hydrolase
I6J81_RS03320	COG3047	cAMP biosynthetic process
I6J81_RS03325	COG3685	Protein conserved in bacteria
I6J81_RS03330	COG3685	Protein conserved in bacteria
I6J81_RS03335	COG3729	General stress protein
I6J81_RS03340	COG0159	tryptophan synthase activity
I6J81_RS03350	COG0134	indole-3-glycerol-phosphate synthase activity
I6J81_RS03350	COG0135	phosphoribosylanthranilate isomerase activity
I6J81_RS03355	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J81_RS03355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J81_RS03360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J81_RS03370	COG0613	PHP domain protein
I6J81_RS03375	COG0009	L-threonylcarbamoyladenylate synthase
I6J81_RS03380	COG4907	membrane protein (DUF2207)
I6J81_RS03385	COG1187	pseudouridine synthase activity
I6J81_RS03390	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6J81_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS03400	COG0616	signal peptide processing
I6J81_RS03410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J81_RS03415	COG0583	DNA-binding transcription factor activity
I6J81_RS03435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J81_RS03445	COG0671	phosphoesterase, PA-phosphatase related
I6J81_RS03450	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6J81_RS03455	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6J81_RS03465	COG0023	Translation Initiation Factor
I6J81_RS03475	COG1349	DNA-binding transcription factor activity
I6J81_RS03485	COG5001	Diguanylate cyclase
I6J81_RS03500	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J81_RS03500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J81_RS03505	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J81_RS03515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS03520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J81_RS03530	COG2814	Major facilitator Superfamily
I6J81_RS03535	COG4172	Belongs to the ABC transporter superfamily
I6J81_RS03540	COG4172	Belongs to the ABC transporter superfamily
I6J81_RS03545	COG4171	peptide transport system, permease
I6J81_RS03550	COG4168	peptide transport system, permease
I6J81_RS03555	COG4166	transmembrane transport
I6J81_RS03565	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6J81_RS03570	COG1842	Phage shock protein A
I6J81_RS03580	COG1983	PspC domain protein
I6J81_RS03590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J81_RS03595	COG0366	Alpha amylase catalytic
I6J81_RS03600	COG1653	transport
I6J81_RS03605	COG1175	transmembrane transport
I6J81_RS03610	COG0395	ABC-type sugar transport system, permease component
I6J81_RS03615	COG1063	alcohol dehydrogenase
I6J81_RS03620	COG1082	Xylose isomerase domain protein TIM barrel
I6J81_RS03625	COG0673	inositol 2-dehydrogenase activity
I6J81_RS03630	COG1554	hydrolase, family 65, central catalytic
I6J81_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J81_RS03650	COG1609	Transcriptional regulator
I6J81_RS03655	COG3106	COG3106 Predicted ATPase
I6J81_RS03665	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6J81_RS03670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J81_RS03675	COG4948	Mandelate Racemase Muconate Lactonizing
I6J81_RS03680	COG2866	Carboxypeptidase
I6J81_RS03685	COG0702	epimerase
I6J81_RS03690	COG1073	alpha beta
I6J81_RS03695	COG0583	DNA-binding transcription factor activity
I6J81_RS03700	COG4166	transmembrane transport
I6J81_RS03705	COG0668	transmembrane transport
I6J81_RS03710	COG3182	Iron-regulated membrane protein
I6J81_RS03715	COG0589	response to stress
I6J81_RS03720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J81_RS03725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J81_RS03735	COG2207	Transcriptional regulator
I6J81_RS03740	COG1566	PFAM secretion protein HlyD family protein
I6J81_RS03750	COG2840	Smr protein MutS2
I6J81_RS03755	COG3706	GGDEF domain
I6J81_RS03765	COG0513	Belongs to the DEAD box helicase family
I6J81_RS03790	COG0589	response to stress
I6J81_RS03795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J81_RS03800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J81_RS03800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J81_RS03800	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J81_RS03800	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J81_RS03805	COG3042	response to heat
I6J81_RS03810	COG3187	Heat shock protein
I6J81_RS03815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J81_RS03820	COG2911	Protein conserved in bacteria
I6J81_RS03830	COG3784	Protein of unknown function (DUF1318)
I6J81_RS03840	COG0667	Aldo Keto reductase
I6J81_RS03850	COG1643	Atp-dependent helicase
I6J81_RS03855	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J81_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS03865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J81_RS03870	COG3038	cytochrome b561
I6J81_RS03890	COG0583	DNA-binding transcription factor activity
I6J81_RS03895	COG5383	Protein conserved in bacteria
I6J81_RS03905	COG2841	Protein conserved in bacteria
I6J81_RS03910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J81_RS03915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J81_RS03920	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6J81_RS03925	COG0500	methyltransferase
I6J81_RS03935	COG3135	benzoate transporter
I6J81_RS03940	COG1396	sequence-specific DNA binding
I6J81_RS03945	COG0826	peptidase U32
I6J81_RS03960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J81_RS03965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J81_RS03970	COG3842	ATPase activity
I6J81_RS03975	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J81_RS03980	COG1177	transmembrane transport
I6J81_RS04005	COG3238	Protein conserved in bacteria
I6J81_RS04010	COG1247	-acetyltransferase
I6J81_RS04020	COG4772	TonB-dependent receptor
I6J81_RS04030	COG1113	amino acid transport
I6J81_RS04045	COG3501	Rhs element vgr protein
I6J81_RS04080	COG3501	Rhs element vgr protein
I6J81_RS04105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J81_RS04110	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J81_RS04115	COG0384	phenazine biosynthesis protein PhzF
I6J81_RS04120	COG2181	nitrate reductase activity
I6J81_RS04125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J81_RS04130	COG1140	nitrate reductase beta subunit
I6J81_RS04135	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J81_RS04140	COG2223	nitrite transmembrane transporter activity
I6J81_RS04145	COG0697	spore germination
I6J81_RS04155	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS04160	COG2864	formate dehydrogenase
I6J81_RS04165	COG3093	addiction module antidote protein HigA
I6J81_RS04175	COG1064	alcohol dehydrogenase
I6J81_RS04195	COG1764	response to oxidative stress
I6J81_RS04200	COG2200	EAL domain
I6J81_RS04200	COG2202	Pas domain
I6J81_RS04200	COG2199	diguanylate cyclase activity
I6J81_RS04210	COG1649	PFAM Uncharacterised BCR, COG1649
I6J81_RS04215	COG0531	amino acid
I6J81_RS04220	COG0076	glutamate decarboxylase activity
I6J81_RS04225	COG0612	Peptidase, M16
I6J81_RS04230	COG4771	TonB-dependent receptor
I6J81_RS04235	COG4178	(ABC) transporter
I6J81_RS04245	COG0641	radical SAM
I6J81_RS04250	COG3119	arylsulfatase activity
I6J81_RS04265	COG0243	molybdopterin cofactor binding
I6J81_RS04270	COG3539	Fimbrial protein
I6J81_RS04275	COG3539	Fimbrial protein
I6J81_RS04280	COG3539	Fimbrial protein
I6J81_RS04285	COG3188	usher protein
I6J81_RS04295	COG3539	Fimbrial protein
I6J81_RS04305	COG0702	epimerase
I6J81_RS04400	COG4128	Pfam Zonular occludens toxin
I6J81_RS04460	COG4128	Pfam Zonular occludens toxin
I6J81_RS04520	COG4128	Pfam Zonular occludens toxin
I6J81_RS04570	COG3550	peptidyl-serine autophosphorylation
I6J81_RS04575	COG1396	sequence-specific DNA binding
I6J81_RS04580	COG4106	trans-aconitate 2-methyltransferase activity
I6J81_RS04585	COG3781	membrane
I6J81_RS04595	COG2199	diguanylate cyclase activity
I6J81_RS04605	COG2066	Belongs to the glutaminase family
I6J81_RS04610	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS04615	COG0583	DNA-binding transcription factor activity
I6J81_RS04635	COG1846	Transcriptional regulator
I6J81_RS04640	COG4977	sequence-specific DNA binding
I6J81_RS04650	COG2723	6-phospho-beta-galactosidase activity
I6J81_RS04660	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J81_RS04665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J81_RS04675	COG2188	Transcriptional regulator
I6J81_RS04680	COG0697	spore germination
I6J81_RS04685	COG2814	Major facilitator Superfamily
I6J81_RS04695	COG3706	GGDEF domain
I6J81_RS04700	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J81_RS04705	COG0339	signal peptide processing
I6J81_RS04710	COG4221	oxidoreductase activity
I6J81_RS04715	COG1802	Transcriptional regulator
I6J81_RS04730	COG0477	Major facilitator Superfamily
I6J81_RS04735	COG1063	alcohol dehydrogenase
I6J81_RS04740	COG4948	Mandelate Racemase Muconate Lactonizing
I6J81_RS04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J81_RS04770	COG0243	molybdopterin cofactor binding
I6J81_RS04775	COG0243	molybdopterin cofactor binding
I6J81_RS04780	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS04785	COG3302	dmso reductase anchor subunit
I6J81_RS04790	COG3381	protein complex oligomerization
I6J81_RS04800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J81_RS04805	COG1940	carbohydrate kinase activity
I6J81_RS04810	COG0583	DNA-binding transcription factor activity
I6J81_RS04815	COG2814	Major facilitator Superfamily
I6J81_RS04830	COG3591	Belongs to the peptidase S1B family
I6J81_RS04845	COG0628	permease
I6J81_RS04850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6J81_RS04855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J81_RS04865	COG0531	amino acid
I6J81_RS04875	COG3136	membrane protein required for alginate biosynthesis
I6J81_RS04880	COG0745	RESPONSE REGULATOR receiver
I6J81_RS04890	COG0114	fumarate hydratase activity
I6J81_RS04895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J81_RS04895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J81_RS04900	COG1482	cell wall glycoprotein biosynthetic process
I6J81_RS04905	COG5339	Protein conserved in bacteria
I6J81_RS04920	COG3250	beta-galactosidase activity
I6J81_RS04925	COG1309	transcriptional regulator
I6J81_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS04935	COG1609	Transcriptional regulator
I6J81_RS04940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS04940	COG1263	PTS System
I6J81_RS04945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J81_RS04955	COG0673	inositol 2-dehydrogenase activity
I6J81_RS04990	COG4658	electron transport chain
I6J81_RS04995	COG4659	FMN binding
I6J81_RS05005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J81_RS05010	COG3104	oligopeptide transport
I6J81_RS05015	COG0625	glutathione transferase activity
I6J81_RS05020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6J81_RS05035	COG3895	Periplasmic Protein
I6J81_RS05045	COG3133	Outer membrane lipoprotein
I6J81_RS05060	COG1566	PFAM secretion protein HlyD family protein
I6J81_RS05065	COG1289	transmembrane transporter activity
I6J81_RS05070	COG2032	superoxide dismutase activity
I6J81_RS05075	COG4989	oxidoreductase activity
I6J81_RS05080	COG3313	Fe-S protein
I6J81_RS05085	COG1309	transcriptional regulator
I6J81_RS05090	COG1902	pentaerythritol trinitrate reductase activity
I6J81_RS05095	COG0346	lactoylglutathione lyase activity
I6J81_RS05105	COG1201	RNA secondary structure unwinding
I6J81_RS05110	COG1201	RNA secondary structure unwinding
I6J81_RS05115	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J81_RS05120	COG0791	NLP P60 protein
I6J81_RS05125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J81_RS05130	COG2814	Major facilitator Superfamily
I6J81_RS05145	COG0583	DNA-binding transcription factor activity
I6J81_RS05150	COG2814	Major facilitator Superfamily
I6J81_RS05155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J81_RS05160	COG0307	riboflavin synthase, alpha
I6J81_RS05170	COG3468	outer membrane autotransporter barrel domain protein
I6J81_RS05190	COG4529	Protein conserved in bacteria
I6J81_RS05200	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6J81_RS05205	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS05215	COG2414	aldehyde ferredoxin oxidoreductase
I6J81_RS05220	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS05230	COG0469	pyruvate kinase activity
I6J81_RS05235	COG4238	major outer membrane lipoprotein
I6J81_RS05240	COG1376	ErfK ybiS ycfS ynhG family protein
I6J81_RS05255	COG0719	Fe-S assembly protein
I6J81_RS05260	COG0396	ATPase activity
I6J81_RS05265	COG0719	Fe-S assembly protein
I6J81_RS05270	COG0316	Belongs to the HesB IscA family
I6J81_RS05280	COG2050	protein possibly involved in aromatic compounds catabolism
I6J81_RS05285	COG0247	lactate metabolic process
I6J81_RS05285	COG0277	FAD linked oxidase domain protein
I6J81_RS05290	COG0628	permease
I6J81_RS05305	COG0738	Major facilitator superfamily
I6J81_RS05310	COG2271	Major facilitator Superfamily
I6J81_RS05325	COG4670	ketone body catabolic process
I6J81_RS05330	COG1960	acyl-CoA dehydrogenase activity
I6J81_RS05335	COG2207	Transcriptional regulator
I6J81_RS05335	COG1917	Cupin 2, conserved barrel domain protein
I6J81_RS05340	COG2086	electron transfer activity
I6J81_RS05345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J81_RS05350	COG0644	oxidoreductase
I6J81_RS05355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J81_RS05360	COG0318	PFAM AMP-dependent synthetase and ligase
I6J81_RS05365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J81_RS05365	COG0574	Belongs to the PEP-utilizing enzyme family
I6J81_RS05375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J81_RS05380	COG4256	Hemin uptake protein
I6J81_RS05390	COG2200	EAL domain
I6J81_RS05395	COG0791	NLP P60 protein
I6J81_RS05405	COG0386	Belongs to the glutathione peroxidase family
I6J81_RS05465	COG3137	Salt-induced outer membrane protein
I6J81_RS05470	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J81_RS05480	COG3001	Fructosamine kinase
I6J81_RS05490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J81_RS05495	COG1988	membrane-bound metal-dependent
I6J81_RS05500	COG1823	symporter activity
I6J81_RS05510	COG0753	catalase activity
I6J81_RS05520	COG1486	melibiose metabolic process
I6J81_RS05525	COG2169	Transcriptional regulator
I6J81_RS05525	COG1917	Cupin 2, conserved barrel domain protein
I6J81_RS05530	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J81_RS05535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J81_RS05540	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J81_RS05545	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J81_RS05555	COG0322	excinuclease ABC activity
I6J81_RS05565	COG3678	ATP-independent chaperone mediated protein folding
I6J81_RS05595	COG0708	Exodeoxyribonuclease III
I6J81_RS05600	COG0398	Pfam SNARE associated Golgi protein
I6J81_RS05610	COG0398	Pfam SNARE associated Golgi protein
I6J81_RS05615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J81_RS05620	COG4134	Bacterial extracellular solute-binding protein
I6J81_RS05625	COG4135	transport system, permease component
I6J81_RS05630	COG4136	ATPase activity
I6J81_RS05635	COG2897	thiosulfate sulfurtransferase activity
I6J81_RS05640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J81_RS05645	COG0494	nUDIX hydrolase
I6J81_RS05655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J81_RS05660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J81_RS05665	COG0709	Synthesizes selenophosphate from selenide and ATP
I6J81_RS05670	COG0778	Nitroreductase
I6J81_RS05675	COG0616	signal peptide processing
I6J81_RS05680	COG0252	asparaginase activity
I6J81_RS05685	COG1335	isochorismatase
I6J81_RS05690	COG2814	Major facilitator Superfamily
I6J81_RS05695	COG1349	DNA-binding transcription factor activity
I6J81_RS05700	COG0667	Aldo Keto reductase
I6J81_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS05710	COG0191	fructose-bisphosphate aldolase activity
I6J81_RS05715	COG1063	alcohol dehydrogenase
I6J81_RS05720	COG2271	Major facilitator Superfamily
I6J81_RS05725	COG1063	alcohol dehydrogenase
I6J81_RS05730	COG3139	Protein of unknown function (DUF1315)
I6J81_RS05740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J81_RS05745	COG0676	glucose-6-phosphate 1-epimerase activity
I6J81_RS05750	COG0656	L-ascorbic acid biosynthetic process
I6J81_RS05755	COG3713	MltA-interacting MipA family protein
I6J81_RS05760	COG2766	serine protein kinase
I6J81_RS05770	COG2199	diguanylate cyclase activity
I6J81_RS05775	COG2199	diguanylate cyclase activity
I6J81_RS05780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J81_RS05795	COG2207	Transcriptional regulator
I6J81_RS05800	COG2807	transmembrane transport
I6J81_RS05805	COG3189	MarR family transcriptional regulator
I6J81_RS05810	COG3042	response to heat
I6J81_RS05815	COG2199	diguanylate cyclase activity
I6J81_RS05815	COG2203	Gaf domain
I6J81_RS05830	COG2261	transglycosylase associated protein
I6J81_RS05840	COG3615	Tellurite resistance protein tehB
I6J81_RS05850	COG0583	DNA-binding transcription factor activity
I6J81_RS05855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6J81_RS05860	COG0318	PFAM AMP-dependent synthetase and ligase
I6J81_RS05865	COG3065	identical protein binding
I6J81_RS05870	COG1214	PFAM Peptidase M22, glycoprotease
I6J81_RS05875	COG1199	ATP-dependent helicase activity
I6J81_RS05880	COG0251	oxidation-reduction process
I6J81_RS05895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J81_RS05905	COG1760	l-serine dehydratase
I6J81_RS05910	COG2200	EAL domain
I6J81_RS05915	COG1253	flavin adenine dinucleotide binding
I6J81_RS05920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS05920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS05925	COG3715	PTS system
I6J81_RS05930	COG3716	PTS system mannose fructose sorbose family IID component
I6J81_RS05945	COG2226	methyltransferase
I6J81_RS05975	COG1414	Transcriptional regulator
I6J81_RS05980	COG2814	Major facilitator Superfamily
I6J81_RS05990	COG0793	Belongs to the peptidase S41A family
I6J81_RS06000	COG1956	GAF domain-containing protein
I6J81_RS06005	COG2995	paraquat-inducible protein a
I6J81_RS06010	COG3008	intermembrane lipid transfer
I6J81_RS06015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J81_RS06015	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J81_RS06030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J81_RS06040	COG1276	copper resistance
I6J81_RS06045	COG2372	response to copper ion
I6J81_RS06055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J81_RS06060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J81_RS06065	COG1770	oligopeptidase
I6J81_RS06070	COG2979	Protein of unknown function (DUF533)
I6J81_RS06080	COG3141	response to X-ray
I6J81_RS06090	COG0800	Aldolase
I6J81_RS06095	COG0129	dihydroxy-acid dehydratase activity
I6J81_RS06100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J81_RS06105	COG1737	Transcriptional regulator
I6J81_RS06110	COG0469	pyruvate kinase activity
I6J81_RS06115	COG1560	Kdo2-lipid A biosynthetic process
I6J81_RS06120	COG0739	heme binding
I6J81_RS06125	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6J81_RS06135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J81_RS06165	COG0217	transcriptional regulatory protein
I6J81_RS06170	COG0494	nUDIX hydrolase
I6J81_RS06180	COG1335	isochorismatase
I6J81_RS06185	COG1801	Protein of unknown function DUF72
I6J81_RS06190	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6J81_RS06205	COG0243	molybdopterin cofactor binding
I6J81_RS06210	COG3005	denitrification pathway
I6J81_RS06220	COG3102	Protein conserved in bacteria
I6J81_RS06235	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J81_RS06240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J81_RS06245	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6J81_RS06250	COG0745	RESPONSE REGULATOR receiver
I6J81_RS06260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J81_RS06270	COG0840	transmembrane signaling receptor activity
I6J81_RS06275	COG0835	chemotaxis
I6J81_RS06280	COG2198	Histidine kinase
I6J81_RS06280	COG0643	Histidine kinase
I6J81_RS06285	COG1360	Flagellar Motor Protein
I6J81_RS06290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6J81_RS06305	COG0589	response to stress
I6J81_RS06315	COG1877	trehalose-phosphatase activity
I6J81_RS06320	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS06330	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS06335	COG1528	Iron-storage protein
I6J81_RS06355	COG1528	Iron-storage protein
I6J81_RS06365	COG0814	amino acid
I6J81_RS06370	COG3318	Belongs to the UPF0149 family
I6J81_RS06370	COG3012	SEC-C Motif Domain Protein
I6J81_RS06400	COG2197	response regulator
I6J81_RS06415	COG2197	response regulator
I6J81_RS06420	COG1126	abc transporter atp-binding protein
I6J81_RS06425	COG0765	amino acid transport
I6J81_RS06435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS06445	COG1191	sigma factor activity
I6J81_RS06455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6J81_RS06460	COG1516	flagellar protein fliS
I6J81_RS06470	COG0366	Alpha amylase catalytic
I6J81_RS06480	COG2391	methyltransferase activity
I6J81_RS06485	COG0425	Belongs to the sulfur carrier protein TusA family
I6J81_RS06490	COG2135	peptidase activity
I6J81_RS06505	COG2207	Transcriptional regulator
I6J81_RS06510	COG1881	PFAM PEBP family protein
I6J81_RS06515	COG2076	Multidrug Resistance protein
I6J81_RS06525	COG1766	The M ring may be actively involved in energy transduction
I6J81_RS06530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J81_RS06535	COG1317	bacterial-type flagellum organization
I6J81_RS06540	COG1157	protein secretion by the type III secretion system
I6J81_RS06545	COG2882	bacterial-type flagellum organization
I6J81_RS06550	COG3144	bacterial-type flagellum assembly
I6J81_RS06555	COG1580	Controls the rotational direction of flagella during chemotaxis
I6J81_RS06560	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J81_RS06565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J81_RS06570	COG3190	flagellar
I6J81_RS06575	COG1338	Plays a role in the flagellum-specific transport system
I6J81_RS06580	COG1987	bacterial-type flagellum assembly
I6J81_RS06585	COG1684	flagellar biosynthetic protein fliR
I6J81_RS06590	COG2197	response regulator
I6J81_RS06610	COG3706	GGDEF domain
I6J81_RS06615	COG5475	Uncharacterized small protein (DUF2158)
I6J81_RS06620	COG2354	Protein conserved in bacteria
I6J81_RS06625	COG0697	spore germination
I6J81_RS06630	COG3727	T/G mismatch-specific endonuclease activity
I6J81_RS06635	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J81_RS06640	COG1418	mRNA catabolic process
I6J81_RS06650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J81_RS06660	COG2205	protein histidine kinase activity
I6J81_RS06665	COG0745	RESPONSE REGULATOR receiver
I6J81_RS06670	COG2351	hydroxyisourate hydrolase activity
I6J81_RS06675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J81_RS06680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6J81_RS06685	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6J81_RS06690	COG0582	viral genome integration into host DNA
I6J81_RS06720	COG4916	TIR domain
I6J81_RS06830	COG0582	viral genome integration into host DNA
I6J81_RS06840	COG2814	Major facilitator Superfamily
I6J81_RS06845	COG1132	(ABC) transporter
I6J81_RS06880	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J81_RS06885	COG4771	TonB-dependent receptor
I6J81_RS06890	COG4932	domain protein
I6J81_RS06890	COG2373	Large extracellular alpha-helical protein
I6J81_RS06890	COG1388	LysM domain
I6J81_RS06905	COG0477	Major facilitator Superfamily
I6J81_RS06910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J81_RS06915	COG0217	transcriptional regulatory protein
I6J81_RS06925	COG0583	DNA-binding transcription factor activity
I6J81_RS06930	COG0583	DNA-binding transcription factor activity
I6J81_RS06940	COG0534	Mate efflux family protein
I6J81_RS06950	COG0582	viral genome integration into host DNA
I6J81_RS06960	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J81_RS06985	COG0154	amidase activity
I6J81_RS07015	COG1960	acyl-CoA dehydrogenase activity
I6J81_RS07020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J81_RS07025	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J81_RS07040	COG2197	response regulator
I6J81_RS07060	COG1376	ErfK ybiS ycfS ynhG family protein
I6J81_RS07075	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6J81_RS07135	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J81_RS07150	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6J81_RS07160	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS07165	COG1454	alcohol dehydrogenase
I6J81_RS07165	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS07170	COG4656	Part of a membrane complex involved in electron transport
I6J81_RS07195	COG1289	transmembrane transporter activity
I6J81_RS07205	COG1686	Belongs to the peptidase S11 family
I6J81_RS07210	COG2925	Exonuclease
I6J81_RS07215	COG0531	amino acid
I6J81_RS07225	COG0583	DNA-binding transcription factor activity
I6J81_RS07230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J81_RS07235	COG4115	mRNA cleavage
I6J81_RS07240	COG2161	toxin-antitoxin pair type II binding
I6J81_RS07255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J81_RS07265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J81_RS07265	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J81_RS07270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J81_RS07290	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J81_RS07295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J81_RS07300	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J81_RS07310	COG5433	transposase activity
I6J81_RS07340	COG2244	polysaccharide biosynthetic process
I6J81_RS07360	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J81_RS07375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J81_RS07385	COG0438	transferase activity, transferring glycosyl groups
I6J81_RS07390	COG2327	Polysaccharide pyruvyl transferase
I6J81_RS07395	COG2244	polysaccharide biosynthetic process
I6J81_RS07400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J81_RS07405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J81_RS07410	COG0662	Cupin 2, conserved barrel domain protein
I6J81_RS07410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J81_RS07415	COG0297	glycogen (starch) synthase activity
I6J81_RS07420	COG1051	belongs to the nudix hydrolase family
I6J81_RS07425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J81_RS07430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J81_RS07435	COG0110	maltose O-acetyltransferase activity
I6J81_RS07440	COG1216	Glycosyl transferase, family 2
I6J81_RS07450	COG0438	transferase activity, transferring glycosyl groups
I6J81_RS07455	COG1045	serine acetyltransferase
I6J81_RS07460	COG0463	Glycosyl transferase, family 2
I6J81_RS07465	COG0489	protein tyrosine kinase activity
I6J81_RS07465	COG3206	protein involved in exopolysaccharide biosynthesis
I6J81_RS07470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J81_RS07475	COG1596	polysaccharide export
I6J81_RS07485	COG1253	flavin adenine dinucleotide binding
I6J81_RS07490	COG2982	Protein involved in outer membrane biogenesis
I6J81_RS07500	COG0572	uridine kinase
I6J81_RS07505	COG5002	protein histidine kinase activity
I6J81_RS07505	COG5001	Diguanylate cyclase
I6J81_RS07505	COG3447	MASE1 domain protein
I6J81_RS07510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J81_RS07515	COG0443	Heat shock 70 kDa protein
I6J81_RS07520	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6J81_RS07525	COG0631	protein serine/threonine phosphatase activity
I6J81_RS07530	COG4245	von Willebrand factor, type A
I6J81_RS07565	COG2205	protein histidine kinase activity
I6J81_RS07570	COG0745	RESPONSE REGULATOR receiver
I6J81_RS07580	COG0826	peptidase U32
I6J81_RS07600	COG1063	alcohol dehydrogenase
I6J81_RS07605	COG3775	system Galactitol-specific IIC component
I6J81_RS07610	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J81_RS07615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS07630	COG1830	Aldolase
I6J81_RS07635	COG2211	Major facilitator Superfamily
I6J81_RS07640	COG1397	ADP-ribosylglycohydrolase
I6J81_RS07645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS07650	COG2188	Transcriptional regulator
I6J81_RS07655	COG3757	hydrolase, family 25
I6J81_RS07660	COG0351	phosphomethylpyrimidine kinase
I6J81_RS07680	COG5455	response to cobalt ion
I6J81_RS07685	COG3539	Fimbrial protein
I6J81_RS07690	COG3188	usher protein
I6J81_RS07695	COG3121	Chaperone
I6J81_RS07700	COG3539	Fimbrial protein
I6J81_RS07710	COG0489	protein tyrosine kinase activity
I6J81_RS07720	COG3831	ATPase activity
I6J81_RS07725	COG3831	ATPase activity
I6J81_RS07735	COG0714	Associated with various cellular activities
I6J81_RS07740	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6J81_RS07745	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J81_RS07750	COG4715	Zinc finger, swim domain protein
I6J81_RS07755	COG4808	Protein conserved in bacteria
I6J81_RS07760	COG4807	Protein conserved in bacteria
I6J81_RS07765	COG3279	Response regulator of the LytR AlgR family
I6J81_RS07770	COG3275	phosphorelay sensor kinase activity
I6J81_RS07775	COG0789	Transcriptional regulator
I6J81_RS07785	COG1174	glycine betaine transport
I6J81_RS07790	COG1125	glycine betaine transport
I6J81_RS07795	COG1174	glycine betaine transport
I6J81_RS07800	COG1732	Glycine betaine
I6J81_RS07805	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J81_RS07810	COG0277	FAD linked oxidase domain protein
I6J81_RS07815	COG1686	Belongs to the peptidase S11 family
I6J81_RS07825	COG0586	Pfam SNARE associated Golgi protein
I6J81_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS07835	COG1538	Outer membrane efflux protein
I6J81_RS07845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J81_RS07855	COG1346	cytolysis
I6J81_RS07865	COG2949	membrane
I6J81_RS07875	COG0493	'glutamate synthase
I6J81_RS07880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J81_RS07880	COG0167	dihydroorotate dehydrogenase activity
I6J81_RS07885	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS07895	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS07900	COG1609	Transcriptional regulator
I6J81_RS07905	COG2311	Membrane
I6J81_RS07915	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6J81_RS07920	COG4771	TonB-dependent receptor
I6J81_RS07925	COG0833	amino acid
I6J81_RS07930	COG0583	DNA-binding transcription factor activity
I6J81_RS07935	COG2855	membrane
I6J81_RS07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS07945	COG1522	sequence-specific DNA binding
I6J81_RS07955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J81_RS07960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J81_RS07965	COG2313	pseudouridylate synthase activity
I6J81_RS07970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS07975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J81_RS07975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS07975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS07980	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J81_RS07985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS07985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS07990	COG2814	Major facilitator Superfamily
I6J81_RS08005	COG0246	Mannitol dehydrogenase
I6J81_RS08010	COG0523	cobalamin synthesis protein
I6J81_RS08015	COG0671	phosphoesterase, PA-phosphatase related
I6J81_RS08020	COG0791	NLP P60 protein
I6J81_RS08025	COG2200	EAL domain
I6J81_RS08030	COG4166	transmembrane transport
I6J81_RS08035	COG4174	ABC transporter (Permease)
I6J81_RS08040	COG4239	(ABC) transporter, permease
I6J81_RS08045	COG4172	Belongs to the ABC transporter superfamily
I6J81_RS08055	COG2814	Major facilitator Superfamily
I6J81_RS08060	COG1187	pseudouridine synthase activity
I6J81_RS08065	COG1061	Type III restriction enzyme res subunit
I6J81_RS08085	COG3083	sulfuric ester hydrolase activity
I6J81_RS08100	COG2197	response regulator
I6J81_RS08105	COG3088	subunit of a heme lyase
I6J81_RS08105	COG4235	cytochrome complex assembly
I6J81_RS08110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J81_RS08115	COG1138	Cytochrome C-type biogenesis protein
I6J81_RS08125	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J81_RS08130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J81_RS08135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J81_RS08145	COG3005	denitrification pathway
I6J81_RS08150	COG3043	anaerobic respiration
I6J81_RS08155	COG0348	domain, Protein
I6J81_RS08160	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS08170	COG3062	negative regulation of establishment of protein localization
I6J81_RS08175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS08175	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS08195	COG4615	Cyclic peptide transporter
I6J81_RS08200	COG3145	DNA-N1-methyladenine dioxygenase activity
I6J81_RS08205	COG2169	Transcriptional regulator
I6J81_RS08205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J81_RS08210	COG1477	protein flavinylation
I6J81_RS08215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J81_RS08220	COG0642	Histidine kinase
I6J81_RS08220	COG2198	Histidine kinase
I6J81_RS08225	COG2197	response regulator
I6J81_RS08230	COG0784	Response regulator, receiver
I6J81_RS08230	COG2205	protein histidine kinase activity
I6J81_RS08235	COG3852	Histidine kinase
I6J81_RS08240	COG2204	response regulator
I6J81_RS08245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J81_RS08250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J81_RS08255	COG2031	fatty acid transporter
I6J81_RS08260	COG0183	Belongs to the thiolase family
I6J81_RS08265	COG4676	Protein conserved in bacteria
I6J81_RS08270	COG5445	Predicted secreted protein (DUF2300)
I6J81_RS08275	COG2373	Large extracellular alpha-helical protein
I6J81_RS08280	COG3234	Protein of unknown function (DUF1175)
I6J81_RS08285	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6J81_RS08290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J81_RS08300	COG3468	outer membrane autotransporter barrel domain protein
I6J81_RS08305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J81_RS08310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J81_RS08315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J81_RS08320	COG3642	lipopolysaccharide core region biosynthetic process
I6J81_RS08325	COG0584	glycerophosphoryl diester phosphodiesterase
I6J81_RS08330	COG2271	Major facilitator Superfamily
I6J81_RS08335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J81_RS08345	COG0247	lactate metabolic process
I6J81_RS08350	COG5464	transposase or invertase
I6J81_RS08365	COG2271	Major facilitator Superfamily
I6J81_RS08375	COG1414	Transcriptional regulator
I6J81_RS08420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J81_RS08440	COG0318	PFAM AMP-dependent synthetase and ligase
I6J81_RS08450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J81_RS08465	COG1169	isochorismate synthase
I6J81_RS08470	COG4575	ribosome binding
I6J81_RS08475	COG2153	protein acetylation
I6J81_RS08485	COG2304	oxidoreductase activity
I6J81_RS08490	COG2234	aminopeptidase activity
I6J81_RS08505	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J81_RS08510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J81_RS08520	COG0839	Belongs to the complex I subunit 6 family
I6J81_RS08535	COG1034	ATP synthesis coupled electron transport
I6J81_RS08540	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J81_RS08545	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6J81_RS08565	COG0583	DNA-binding transcription factor activity
I6J81_RS08570	COG0436	Aminotransferase
I6J81_RS08580	COG0490	domain, Protein
I6J81_RS08580	COG0471	metal ion transport
I6J81_RS08585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J81_RS08600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J81_RS08605	COG0280	phosphate acetyltransferase
I6J81_RS08605	COG0857	belongs to the CobB CobQ family
I6J81_RS08610	COG1288	antiporter activity
I6J81_RS08615	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J81_RS08620	COG0622	Phosphoesterase
I6J81_RS08625	COG0625	glutathione transferase activity
I6J81_RS08630	COG0625	glutathione transferase activity
I6J81_RS08635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J81_RS08640	COG1090	epimerase
I6J81_RS08645	COG5464	transposase or invertase
I6J81_RS08650	COG4598	ABC transporter
I6J81_RS08655	COG4160	amino acid transport
I6J81_RS08660	COG4215	(ABC) transporter
I6J81_RS08665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS08675	COG0163	prenyltransferase activity
I6J81_RS08680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J81_RS08685	COG1286	toxin biosynthetic process
I6J81_RS08690	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6J81_RS08695	COG0285	dihydrofolate synthase activity
I6J81_RS08705	COG0586	Pfam SNARE associated Golgi protein
I6J81_RS08715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J81_RS08730	COG2814	Major facilitator Superfamily
I6J81_RS08735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J81_RS08750	COG3101	peptidyl-lysine hydroxylation
I6J81_RS08755	COG0730	response to heat
I6J81_RS08785	COG3539	Fimbrial protein
I6J81_RS08790	COG3539	Fimbrial protein
I6J81_RS08795	COG3539	Fimbrial protein
I6J81_RS08800	COG3121	Chaperone
I6J81_RS08805	COG3188	usher protein
I6J81_RS08810	COG3539	Fimbrial protein
I6J81_RS08815	COG2062	phosphohistidine phosphatase, SixA
I6J81_RS08830	COG3691	Protein conserved in bacteria
I6J81_RS08835	COG2067	long-chain fatty acid transport protein
I6J81_RS08845	COG2116	formate transmembrane transporter activity
I6J81_RS08855	COG0583	DNA-binding transcription factor activity
I6J81_RS08860	COG2610	gluconate transmembrane transporter activity
I6J81_RS08865	COG3048	D-serine ammonia-lyase activity
I6J81_RS08870	COG0477	Major facilitator Superfamily
I6J81_RS08875	COG1566	PFAM secretion protein HlyD family protein
I6J81_RS08880	COG2197	response regulator
I6J81_RS08885	COG2205	protein histidine kinase activity
I6J81_RS08885	COG2198	Histidine kinase
I6J81_RS08885	COG0784	Response regulator, receiver
I6J81_RS08885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS08890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J81_RS08895	COG0679	Auxin Efflux Carrier
I6J81_RS08900	COG0028	Belongs to the TPP enzyme family
I6J81_RS08925	COG1560	Kdo2-lipid A biosynthetic process
I6J81_RS08935	COG0436	Aminotransferase
I6J81_RS08940	COG3275	phosphorelay sensor kinase activity
I6J81_RS08945	COG3279	Response regulator of the LytR AlgR family
I6J81_RS08950	COG2207	Transcriptional regulator
I6J81_RS08955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS08955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS08955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J81_RS08960	COG1363	Peptidase, m42
I6J81_RS08965	COG0006	proline dipeptidase activity
I6J81_RS08970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS08975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS09000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J81_RS09005	COG2200	EAL domain
I6J81_RS09005	COG2199	diguanylate cyclase activity
I6J81_RS09020	COG3415	Transposase
I6J81_RS09025	COG3415	Transposase
I6J81_RS09030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J81_RS09055	COG0583	DNA-binding transcription factor activity
I6J81_RS09065	COG2211	Major facilitator Superfamily
I6J81_RS09070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J81_RS09080	COG0583	DNA-binding transcription factor activity
I6J81_RS09085	COG0385	Bile acid
I6J81_RS09090	COG3530	Putative quorum-sensing-regulated virulence factor
I6J81_RS09110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J81_RS09115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS09120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J81_RS09125	COG2190	(PTS) system
I6J81_RS09140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J81_RS09145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J81_RS09150	COG4208	sulfate ABC transporter
I6J81_RS09155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J81_RS09160	COG4150	thiosulfate binding
I6J81_RS09165	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS09175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS09175	COG1263	PTS System
I6J81_RS09180	COG2837	iron assimilation
I6J81_RS09200	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J81_RS09210	COG2207	Transcriptional regulator
I6J81_RS09215	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J81_RS09220	COG4816	utilization protein
I6J81_RS09230	COG4303	Ethanolamine ammonia lyase large subunit
I6J81_RS09235	COG4819	ethanolamine utilization protein
I6J81_RS09240	COG3192	ethanolamine utilization protein
I6J81_RS09245	COG1454	alcohol dehydrogenase
I6J81_RS09250	COG4820	ethanolamine utilization protein (EutJ)
I6J81_RS09255	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS09260	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6J81_RS09265	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J81_RS09270	COG0280	phosphate acetyltransferase
I6J81_RS09275	COG4812	Cobalamin adenosyltransferase
I6J81_RS09280	COG4766	ethanolamine catabolic process
I6J81_RS09285	COG4917	ethanolamine utilization protein
I6J81_RS09290	COG4810	utilization protein
I6J81_RS09295	COG0280	phosphate acetyltransferase
I6J81_RS09295	COG0281	malic enzyme
I6J81_RS09300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J81_RS09305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J81_RS09310	COG5342	invasion associated locus B
I6J81_RS09320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS09320	COG0493	'glutamate synthase
I6J81_RS09325	COG3850	Histidine kinase
I6J81_RS09330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J81_RS09340	COG1393	Belongs to the ArsC family
I6J81_RS09355	COG0400	carboxylic ester hydrolase activity
I6J81_RS09365	COG2321	neutral zinc metallopeptidase
I6J81_RS09375	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6J81_RS09385	COG2716	regulation of RNA biosynthetic process
I6J81_RS09390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J81_RS09395	COG0628	permease
I6J81_RS09400	COG4783	chaperone-mediated protein folding
I6J81_RS09405	COG1393	Belongs to the ArsC family
I6J81_RS09415	COG2233	PERMEase
I6J81_RS09430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J81_RS09435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J81_RS09440	COG0248	Ppx GppA phosphatase
I6J81_RS09445	COG2200	EAL domain
I6J81_RS09460	COG3133	Outer membrane lipoprotein
I6J81_RS09475	COG0517	IMP dehydrogenase activity
I6J81_RS09475	COG0516	GMP reductase activity
I6J81_RS09500	COG1645	bacterial-type flagellum-dependent swarming motility
I6J81_RS09515	COG2976	Protein conserved in bacteria
I6J81_RS09545	COG4953	penicillin-binding protein 1C
I6J81_RS09550	COG2373	Large extracellular alpha-helical protein
I6J81_RS09555	COG2897	thiosulfate sulfurtransferase activity
I6J81_RS09570	COG2975	iron-sulfur cluster assembly
I6J81_RS09575	COG0633	Ferredoxin
I6J81_RS09595	COG0822	iron-sulfur transferase activity
I6J81_RS09615	COG0483	inositol monophosphate 1-phosphatase activity
I6J81_RS09620	COG1073	alpha beta
I6J81_RS09630	COG2814	Major facilitator Superfamily
I6J81_RS09635	COG2259	Doxx family
I6J81_RS09640	COG2017	converts alpha-aldose to the beta-anomer
I6J81_RS09645	COG1063	alcohol dehydrogenase
I6J81_RS09650	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS09655	COG1129	ABC transporter
I6J81_RS09660	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS09665	COG0457	Tetratricopeptide repeat
I6J81_RS09670	COG1940	carbohydrate kinase activity
I6J81_RS09680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J81_RS09680	COG1017	nitric oxide dioxygenase activity
I6J81_RS09685	COG0347	Belongs to the P(II) protein family
I6J81_RS09690	COG2204	response regulator
I6J81_RS09695	COG3170	Tfp pilus assembly protein FimV
I6J81_RS09700	COG2205	protein histidine kinase activity
I6J81_RS09705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J81_RS09705	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J81_RS09715	COG0590	tRNA wobble adenosine to inosine editing
I6J81_RS09720	COG0560	Phosphoserine phosphatase
I6J81_RS09725	COG1737	Transcriptional regulator
I6J81_RS09730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS09745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J81_RS09765	COG0681	Belongs to the peptidase S26 family
I6J81_RS09775	COG3086	response to oxidative stress
I6J81_RS09780	COG3026	antisigma factor binding
I6J81_RS09785	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6J81_RS09790	COG1595	DNA-templated transcription, initiation
I6J81_RS09800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J81_RS09810	COG0513	Belongs to the DEAD box helicase family
I6J81_RS09815	COG0583	DNA-binding transcription factor activity
I6J81_RS09835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J81_RS09840	COG3118	belongs to the thioredoxin family
I6J81_RS09845	COG3148	PFAM DTW domain containing protein
I6J81_RS09850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J81_RS09850	COG1042	CoA-binding domain protein
I6J81_RS09850	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J81_RS09855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J81_RS09860	COG5544	Lipoprotein
I6J81_RS09865	COG0477	Major facilitator Superfamily
I6J81_RS09900	COG0542	response to heat
I6J81_RS09910	COG0564	pseudouridine synthase activity
I6J81_RS09915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J81_RS09920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J81_RS09930	COG1605	Chorismate mutase
I6J81_RS09930	COG0077	Prephenate dehydratase
I6J81_RS09935	COG0287	Prephenate dehydrogenase
I6J81_RS09935	COG1605	Chorismate mutase
I6J81_RS09940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J81_RS09955	COG2199	diguanylate cyclase activity
I6J81_RS09960	COG2885	chlorophyll binding
I6J81_RS09985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J81_RS09990	COG4137	Cytochrome C assembly protein
I6J81_RS09995	COG4536	flavin adenine dinucleotide binding
I6J81_RS10010	COG0497	DNA recombination
I6J81_RS10015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J81_RS10025	COG2867	negative regulation of translational initiation
I6J81_RS10045	COG0579	oxidoreductase
I6J81_RS10050	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS10055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J81_RS10060	COG1113	amino acid transport
I6J81_RS10065	COG1802	Transcriptional regulator
I6J81_RS10070	COG1652	LysM domain
I6J81_RS10075	COG0401	homolog of Blt101
I6J81_RS10080	COG0640	Transcriptional regulator
I6J81_RS10085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J81_RS10090	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6J81_RS10105	COG4575	ribosome binding
I6J81_RS10115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J81_RS10120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J81_RS10130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J81_RS10135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J81_RS10140	COG4175	Glycine betaine
I6J81_RS10145	COG4176	ABC-type proline glycine betaine transport system permease component
I6J81_RS10150	COG2113	Glycine betaine
I6J81_RS10155	COG2814	Major facilitator Superfamily
I6J81_RS10160	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J81_RS10170	COG1846	Transcriptional regulator
I6J81_RS10175	COG1566	PFAM secretion protein HlyD family protein
I6J81_RS10180	COG2814	Major facilitator Superfamily
I6J81_RS10205	COG1238	metal cluster binding
I6J81_RS10210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J81_RS10240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6J81_RS10260	COG1546	Belongs to the CinA family
I6J81_RS10265	COG2951	lytic endotransglycosylase activity
I6J81_RS10270	COG3730	PTS system glucitol sorbitol-specific
I6J81_RS10275	COG3732	PTS system glucitol sorbitol-specific
I6J81_RS10285	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS10290	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS10295	COG1349	DNA-binding transcription factor activity
I6J81_RS10300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J81_RS10300	COG0517	IMP dehydrogenase activity
I6J81_RS10320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J81_RS10325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS10330	COG1609	Transcriptional regulator
I6J81_RS10335	COG1263	PTS System
I6J81_RS10335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS10340	COG2723	6-phospho-beta-galactosidase activity
I6J81_RS10345	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J81_RS10355	COG3260	NADH ubiquinone oxidoreductase 20
I6J81_RS10360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J81_RS10365	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6J81_RS10365	COG3261	NADH dehydrogenase
I6J81_RS10370	COG0650	Formate hydrogenlyase subunit 4
I6J81_RS10375	COG0651	ATP synthesis coupled electron transport
I6J81_RS10380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS10390	COG0375	protein maturation
I6J81_RS10395	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J81_RS10400	COG0298	carbon dioxide binding
I6J81_RS10405	COG0409	Hydrogenase expression formation protein
I6J81_RS10410	COG0309	Hydrogenase expression formation protein (HypE)
I6J81_RS10415	COG3604	Transcriptional regulator
I6J81_RS10430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J81_RS10435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J81_RS10440	COG1349	DNA-binding transcription factor activity
I6J81_RS10445	COG2084	Dehydrogenase
I6J81_RS10450	COG3395	kinase activity
I6J81_RS10455	COG0235	Class ii aldolase
I6J81_RS10460	COG3622	Belongs to the hyi family
I6J81_RS10465	COG2610	gluconate transmembrane transporter activity
I6J81_RS10480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J81_RS10485	COG4942	peptidase
I6J81_RS10485	COG1388	LysM domain
I6J81_RS10500	COG0585	pseudouridine synthase activity
I6J81_RS10540	COG2234	aminopeptidase activity
I6J81_RS10560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J81_RS10565	COG0720	synthase
I6J81_RS10575	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J81_RS10580	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J81_RS10585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J81_RS10590	COG2086	electron transfer activity
I6J81_RS10595	COG0477	Major facilitator Superfamily
I6J81_RS10600	COG0277	FAD linked oxidase domain protein
I6J81_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS10610	COG2223	nitrite transmembrane transporter activity
I6J81_RS10615	COG1070	Carbohydrate kinase
I6J81_RS10645	COG0602	queuosine metabolic process
I6J81_RS10655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J81_RS10670	COG3956	TIGRFAM MazG family protein
I6J81_RS10675	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J81_RS10680	COG2336	PFAM SpoVT AbrB
I6J81_RS10685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J81_RS10695	COG2205	protein histidine kinase activity
I6J81_RS10695	COG3850	Histidine kinase
I6J81_RS10695	COG4999	Histidine kinase
I6J81_RS10695	COG3437	response regulator, receiver
I6J81_RS10700	COG4948	Mandelate Racemase Muconate Lactonizing
I6J81_RS10705	COG4948	Mandelate Racemase Muconate Lactonizing
I6J81_RS10710	COG2271	Major facilitator Superfamily
I6J81_RS10715	COG0716	FMN binding
I6J81_RS10720	COG0564	pseudouridine synthase activity
I6J81_RS10725	COG3098	single-species biofilm formation
I6J81_RS10740	COG1611	Belongs to the LOG family
I6J81_RS10745	COG0814	amino acid
I6J81_RS10750	COG1760	l-serine dehydratase
I6J81_RS10760	COG1454	alcohol dehydrogenase
I6J81_RS10765	COG0235	Class ii aldolase
I6J81_RS10770	COG0738	Major facilitator superfamily
I6J81_RS10780	COG1070	Carbohydrate kinase
I6J81_RS10790	COG1349	DNA-binding transcription factor activity
I6J81_RS10800	COG2363	Small membrane protein
I6J81_RS10805	COG0583	DNA-binding transcription factor activity
I6J81_RS10815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J81_RS10820	COG2166	iron-sulfur cluster assembly
I6J81_RS10825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J81_RS10830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6J81_RS10870	COG2885	chlorophyll binding
I6J81_RS10965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J81_RS10970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS10970	COG1263	PTS System
I6J81_RS10975	COG3711	transcriptional antiterminator
I6J81_RS10980	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J81_RS10985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J81_RS10985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J81_RS10990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J81_RS10995	COG1074	ATP-dependent DNA helicase activity
I6J81_RS11000	COG1025	Belongs to the peptidase M16 family
I6J81_RS11005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J81_RS11010	COG4967	type IV pilus modification protein PilV
I6J81_RS11020	COG4795	General secretion pathway protein
I6J81_RS11025	COG2165	general secretion pathway protein
I6J81_RS11040	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6J81_RS11055	COG0861	Integral membrane protein TerC family
I6J81_RS11065	COG0667	Aldo Keto reductase
I6J81_RS11080	COG1609	Transcriptional regulator
I6J81_RS11090	COG0583	DNA-binding transcription factor activity
I6J81_RS11095	COG1794	racemase activity, acting on amino acids and derivatives
I6J81_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS11115	COG0183	Belongs to the thiolase family
I6J81_RS11120	COG0814	amino acid
I6J81_RS11130	COG4942	peptidase
I6J81_RS11135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J81_RS11140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J81_RS11145	COG2080	2 iron, 2 sulfur cluster binding
I6J81_RS11150	COG3829	transcription factor binding
I6J81_RS11155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J81_RS11160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J81_RS11165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J81_RS11175	COG0549	Belongs to the carbamate kinase family
I6J81_RS11180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J81_RS11180	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J81_RS11185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J81_RS11190	COG2068	MobA-Related Protein
I6J81_RS11195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS11195	COG0493	'glutamate synthase
I6J81_RS11200	COG0402	S-adenosylhomocysteine deaminase activity
I6J81_RS11205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J81_RS11210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J81_RS11210	COG2080	2 iron, 2 sulfur cluster binding
I6J81_RS11215	COG2233	PERMEase
I6J81_RS11220	COG0402	S-adenosylhomocysteine deaminase activity
I6J81_RS11225	COG2252	PERMEase
I6J81_RS11230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS11235	COG0493	'glutamate synthase
I6J81_RS11235	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS11240	COG2233	PERMEase
I6J81_RS11260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J81_RS11270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J81_RS11275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J81_RS11280	COG4974	Belongs to the 'phage' integrase family
I6J81_RS11285	COG0716	FMN binding
I6J81_RS11295	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J81_RS11305	COG1272	protein, Hemolysin III
I6J81_RS11315	COG2723	6-phospho-beta-galactosidase activity
I6J81_RS11340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J81_RS11345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J81_RS11350	COG0006	proline dipeptidase activity
I6J81_RS11370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J81_RS11380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J81_RS11400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J81_RS11400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J81_RS11405	COG0583	DNA-binding transcription factor activity
I6J81_RS11410	COG2968	Membrane
I6J81_RS11415	COG1279	arginine transmembrane transporter activity
I6J81_RS11420	COG0668	transmembrane transport
I6J81_RS11425	COG0191	fructose-bisphosphate aldolase activity
I6J81_RS11460	COG1122	ATPase activity
I6J81_RS11465	COG1072	(Pantothenic acid kinase))
I6J81_RS11480	COG1063	alcohol dehydrogenase
I6J81_RS11485	COG2213	PTS system mannitol-specific
I6J81_RS11490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS11495	COG0330	HflC and HflK could
I6J81_RS11500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J81_RS11505	COG0501	Belongs to the peptidase M48B family
I6J81_RS11520	COG1166	arginine decarboxylase activity
I6J81_RS11540	COG2814	Major facilitator Superfamily
I6J81_RS11550	COG2356	endonuclease I
I6J81_RS11555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J81_RS11560	COG0189	ligase activity
I6J81_RS11575	COG2805	Type II/IV secretion system protein
I6J81_RS11580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J81_RS11585	COG0762	integral membrane protein
I6J81_RS11595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J81_RS11600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J81_RS11610	COG0252	asparaginase activity
I6J81_RS11620	COG3171	Protein conserved in bacteria
I6J81_RS11630	COG1194	a g-specific adenine glycosylase
I6J81_RS11645	COG2211	Major facilitator Superfamily
I6J81_RS11650	COG1982	Orn Lys Arg decarboxylase major
I6J81_RS11655	COG1811	Na channel or pump
I6J81_RS11665	COG0582	viral genome integration into host DNA
I6J81_RS11795	COG3842	ATPase activity
I6J81_RS11800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS11805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J81_RS11865	COG2814	Major facilitator Superfamily
I6J81_RS11870	COG0673	inositol 2-dehydrogenase activity
I6J81_RS11925	COG0204	Acyl-transferase
I6J81_RS11935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J81_RS11950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J81_RS11955	COG1216	Glycosyl transferase, family 2
I6J81_RS11980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J81_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS11995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J81_RS12005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS12015	COG3037	sugar-specific permease SgaT UlaA
I6J81_RS12030	COG0738	Major facilitator superfamily
I6J81_RS12040	COG1349	DNA-binding transcription factor activity
I6J81_RS12080	COG4983	Phage plasmid primase, P4 family domain protein
I6J81_RS12090	COG3468	outer membrane autotransporter barrel domain protein
I6J81_RS12095	COG2020	methyltransferase activity
I6J81_RS12120	COG2003	Belongs to the UPF0758 family
I6J81_RS12210	COG2089	acid synthase
I6J81_RS12230	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J81_RS12260	COG2165	general secretion pathway protein
I6J81_RS12265	COG1459	type II secretion system
I6J81_RS12270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J81_RS12295	COG3064	Membrane
I6J81_RS12300	COG1620	l-lactate permease
I6J81_RS12305	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J81_RS12310	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J81_RS12315	COG0247	lactate metabolic process
I6J81_RS12320	COG0277	FAD linked oxidase domain protein
I6J81_RS12325	COG0277	FAD linked oxidase domain protein
I6J81_RS12330	COG2186	Transcriptional regulator
I6J81_RS12335	COG0456	acetyltransferase
I6J81_RS12340	COG0318	PFAM AMP-dependent synthetase and ligase
I6J81_RS12350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J81_RS12355	COG0156	8-amino-7-oxononanoate synthase activity
I6J81_RS12365	COG0795	lipopolysaccharide-transporting ATPase activity
I6J81_RS12370	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6J81_RS12380	COG2244	polysaccharide biosynthetic process
I6J81_RS12385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J81_RS12390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J81_RS12395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J81_RS12400	COG0306	phosphate transporter
I6J81_RS12405	COG0754	glutathionylspermidine amidase activity
I6J81_RS12410	COG0625	glutathione transferase activity
I6J81_RS12415	COG0298	carbon dioxide binding
I6J81_RS12420	COG0375	protein maturation
I6J81_RS12425	COG1773	rubredoxin
I6J81_RS12430	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J81_RS12435	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J81_RS12440	COG5557	Pfam Polysulphide reductase, NrfD
I6J81_RS12445	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS12450	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6J81_RS12465	COG0667	Aldo Keto reductase
I6J81_RS12470	COG2862	Uncharacterized protein family, UPF0114
I6J81_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS12480	COG0848	biopolymer transport protein
I6J81_RS12485	COG0811	peptide transport
I6J81_RS12490	COG0626	cystathionine gamma-synthase activity
I6J81_RS12500	COG2207	Transcriptional regulator
I6J81_RS12505	COG1979	alcohol dehydrogenase
I6J81_RS12510	COG0656	L-ascorbic acid biosynthetic process
I6J81_RS12520	COG4238	major outer membrane lipoprotein
I6J81_RS12525	COG1032	radical SAM domain protein
I6J81_RS12530	COG2186	Transcriptional regulator
I6J81_RS12535	COG0246	Mannitol dehydrogenase
I6J81_RS12540	COG1063	alcohol dehydrogenase
I6J81_RS12545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J81_RS12565	COG2132	Multicopper oxidase
I6J81_RS12570	COG0204	Acyl-transferase
I6J81_RS12575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J81_RS12580	COG4166	transmembrane transport
I6J81_RS12585	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J81_RS12590	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J81_RS12595	COG0745	RESPONSE REGULATOR receiver
I6J81_RS12600	COG0642	Histidine kinase
I6J81_RS12615	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J81_RS12620	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J81_RS12625	COG1737	Transcriptional regulator
I6J81_RS12635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS12640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS12645	COG1120	ATPase activity
I6J81_RS12650	COG4774	siderophore transport
I6J81_RS12655	COG0187	DNA topoisomerase II activity
I6J81_RS12660	COG3150	esterase
I6J81_RS12665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J81_RS12670	COG3151	Protein conserved in bacteria
I6J81_RS12675	COG0494	nUDIX hydrolase
I6J81_RS12680	COG1538	Outer membrane efflux protein
I6J81_RS12690	COG0754	glutathionylspermidine amidase activity
I6J81_RS12700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J81_RS12710	COG3384	dioxygenase
I6J81_RS12725	COG3539	Fimbrial protein
I6J81_RS12730	COG3188	usher protein
I6J81_RS12735	COG3121	Chaperone
I6J81_RS12740	COG3539	Fimbrial protein
I6J81_RS12760	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J81_RS12765	COG2268	Band 7 protein
I6J81_RS12780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J81_RS12785	COG3025	triphosphatase activity
I6J81_RS12790	COG4991	sh3 domain protein
I6J81_RS12805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J81_RS12825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J81_RS12830	COG0471	metal ion transport
I6J81_RS12840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J81_RS12845	COG0358	DNA primase activity
I6J81_RS12850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J81_RS12865	COG2375	cellular response to nickel ion
I6J81_RS12870	COG1695	Transcriptional regulator
I6J81_RS12875	COG0840	transmembrane signaling receptor activity
I6J81_RS12885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J81_RS12890	COG1609	Transcriptional regulator
I6J81_RS12895	COG3250	beta-galactosidase activity
I6J81_RS12900	COG2731	YhcH YjgK YiaL family protein
I6J81_RS12905	COG0531	amino acid
I6J81_RS12915	COG3408	Glycogen debranching enzyme
I6J81_RS12915	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6J81_RS12920	COG1902	pentaerythritol trinitrate reductase activity
I6J81_RS12920	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J81_RS12925	COG5499	transcription regulator containing HTH domain
I6J81_RS12940	COG1451	nucleotide metabolic process
I6J81_RS12945	COG2949	membrane
I6J81_RS12950	COG0673	inositol 2-dehydrogenase activity
I6J81_RS12955	COG0861	Integral membrane protein TerC family
I6J81_RS12970	COG2721	sulfolactate sulfo-lyase activity
I6J81_RS12980	COG2271	Major facilitator Superfamily
I6J81_RS12985	COG2186	Transcriptional regulator
I6J81_RS12990	COG0586	Pfam SNARE associated Golgi protein
I6J81_RS13000	COG1422	Protein of unknown function (DUF1090)
I6J81_RS13005	COG4575	ribosome binding
I6J81_RS13010	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6J81_RS13020	COG2259	Doxx family
I6J81_RS13025	COG0435	Glutathione S-transferase
I6J81_RS13030	COG3152	Membrane
I6J81_RS13035	COG0583	DNA-binding transcription factor activity
I6J81_RS13040	COG1741	Belongs to the pirin family
I6J81_RS13055	COG0814	amino acid
I6J81_RS13060	COG1760	l-serine dehydratase
I6J81_RS13065	COG0251	oxidation-reduction process
I6J81_RS13070	COG1882	Formate acetyltransferase
I6J81_RS13075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J81_RS13085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J81_RS13090	COG0583	DNA-binding transcription factor activity
I6J81_RS13105	COG1929	Belongs to the glycerate kinase type-1 family
I6J81_RS13110	COG2084	Dehydrogenase
I6J81_RS13120	COG2271	Major facilitator Superfamily
I6J81_RS13125	COG2721	sulfolactate sulfo-lyase activity
I6J81_RS13130	COG2002	toxin-antitoxin pair type II binding
I6J81_RS13140	COG1349	DNA-binding transcription factor activity
I6J81_RS13150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS13160	COG3716	PTS system mannose fructose sorbose family IID component
I6J81_RS13165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS13170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J81_RS13175	COG2222	sugar isomerase
I6J81_RS13185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS13190	COG3715	PTS system
I6J81_RS13195	COG3716	PTS system mannose fructose sorbose family IID component
I6J81_RS13200	COG0363	glucosamine-6-phosphate deaminase activity
I6J81_RS13205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J81_RS13225	COG2823	Periplasmic or secreted lipoprotein
I6J81_RS13230	COG0701	Predicted permease
I6J81_RS13235	COG0702	epimerase
I6J81_RS13240	COG0693	protein deglycase activity
I6J81_RS13255	COG3153	acetyltransferase
I6J81_RS13260	COG3154	lipid carrier protein
I6J81_RS13265	COG0826	peptidase U32
I6J81_RS13270	COG0826	peptidase U32
I6J81_RS13275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J81_RS13280	COG0814	amino acid
I6J81_RS13285	COG0513	Belongs to the DEAD box helicase family
I6J81_RS13325	COG0195	Participates in both transcription termination and antitermination
I6J81_RS13345	COG2194	sulfuric ester hydrolase activity
I6J81_RS13355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J81_RS13365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J81_RS13370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J81_RS13380	COG1534	Rna-binding protein
I6J81_RS13385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J81_RS13390	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J81_RS13400	COG0697	spore germination
I6J81_RS13415	COG0142	geranyltranstransferase activity
I6J81_RS13420	COG3423	Transcriptional regulator
I6J81_RS13430	COG5007	Belongs to the BolA IbaG family
I6J81_RS13435	COG3113	response to antibiotic
I6J81_RS13440	COG2854	intermembrane phospholipid transfer
I6J81_RS13445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J81_RS13450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J81_RS13455	COG1127	ABC transporter
I6J81_RS13460	COG0530	calcium, potassium:sodium antiporter activity
I6J81_RS13465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J81_RS13465	COG0517	IMP dehydrogenase activity
I6J81_RS13470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J81_RS13475	COG3117	lipopolysaccharide transmembrane transporter activity
I6J81_RS13480	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J81_RS13485	COG1137	ATPase activity
I6J81_RS13490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6J81_RS13495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J81_RS13510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS13515	COG0515	serine threonine protein kinase
I6J81_RS13525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J81_RS13530	COG5002	protein histidine kinase activity
I6J81_RS13530	COG2198	Histidine kinase
I6J81_RS13530	COG0784	Response regulator, receiver
I6J81_RS13535	COG1242	4 iron, 4 sulfur cluster binding
I6J81_RS13540	COG0067	glutamate synthase
I6J81_RS13540	COG0069	glutamate synthase activity
I6J81_RS13540	COG0070	glutamate synthase
I6J81_RS13545	COG0493	'glutamate synthase
I6J81_RS13550	COG2731	YhcH YjgK YiaL family protein
I6J81_RS13555	COG1940	carbohydrate kinase activity
I6J81_RS13580	COG2969	positive regulation of protein catabolic process
I6J81_RS13585	COG0625	glutathione transferase activity
I6J81_RS13600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J81_RS13605	COG3105	Protein conserved in bacteria
I6J81_RS13610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J81_RS13615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J81_RS13635	COG2732	(Barnase) inhibitor
I6J81_RS13655	COG0583	DNA-binding transcription factor activity
I6J81_RS13660	COG0312	modulator of DNA gyrase
I6J81_RS13665	COG3164	Protein of unknown function
I6J81_RS13670	COG1530	ribonuclease E activity
I6J81_RS13680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J81_RS13685	COG1792	Involved in formation and maintenance of cell shape
I6J81_RS13690	COG1077	Cell shape determining protein MreB Mrl
I6J81_RS13695	COG2200	EAL domain
I6J81_RS13695	COG2199	diguanylate cyclase activity
I6J81_RS13700	COG0604	alcohol dehydrogenase
I6J81_RS13710	COG0511	ligase activity, forming carbon-carbon bonds
I6J81_RS13715	COG0439	Biotin carboxylase
I6J81_RS13725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS13730	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS13735	COG1129	ABC transporter
I6J81_RS13740	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS13750	COG1349	DNA-binding transcription factor activity
I6J81_RS13755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS13760	COG3924	membrane
I6J81_RS13765	COG4145	pantothenate transmembrane transporter activity
I6J81_RS13775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J81_RS13785	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6J81_RS13795	COG1309	transcriptional regulator
I6J81_RS13800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS13805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J81_RS13815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS13820	COG4597	amino acid ABC transporter
I6J81_RS13825	COG0765	amino acid transport
I6J81_RS13830	COG1126	abc transporter atp-binding protein
I6J81_RS13870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J81_RS13890	COG0551	DNA topoisomerase type I activity
I6J81_RS13900	COG0758	DNA mediated transformation
I6J81_RS13920	COG0569	domain protein
I6J81_RS13930	COG3036	rescue of stalled ribosome
I6J81_RS13935	COG0789	Transcriptional regulator
I6J81_RS13975	COG0201	protein transport
I6J81_RS14065	COG0089	rRNA binding
I6J81_RS14090	COG3409	Peptidoglycan-binding domain 1 protein
I6J81_RS14090	COG3267	Type II secretory pathway component ExeA
I6J81_RS14095	COG3031	protein transport across the cell outer membrane
I6J81_RS14100	COG1450	Type ii and iii secretion system protein
I6J81_RS14105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J81_RS14110	COG1459	type II secretion system
I6J81_RS14115	COG2165	general secretion pathway protein
I6J81_RS14120	COG2165	general secretion pathway protein
I6J81_RS14125	COG2165	general secretion pathway protein
I6J81_RS14130	COG4795	General secretion pathway protein
I6J81_RS14135	COG3156	type II secretion system protein K
I6J81_RS14140	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J81_RS14145	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J81_RS14150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J81_RS14155	COG2193	ferroxidase activity
I6J81_RS14160	COG2906	2 iron, 2 sulfur cluster binding
I6J81_RS14165	COG3979	chitinase
I6J81_RS14205	COG2964	Protein conserved in bacteria
I6J81_RS14210	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J81_RS14220	COG1047	Peptidyl-prolyl cis-trans
I6J81_RS14225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J81_RS14240	COG0488	(ABC) transporter
I6J81_RS14245	COG0429	hydrolase of the alpha beta-hydrolase fold
I6J81_RS14255	COG3954	Phosphoribulokinase
I6J81_RS14260	COG1765	OsmC-like protein
I6J81_RS14265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J81_RS14270	COG1289	transmembrane transporter activity
I6J81_RS14275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J81_RS14280	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J81_RS14285	COG2184	nucleotidyltransferase activity
I6J81_RS14295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J81_RS14305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J81_RS14310	COG2146	nitrite reductase [NAD(P)H] activity
I6J81_RS14315	COG2116	formate transmembrane transporter activity
I6J81_RS14330	COG0626	cystathionine gamma-synthase activity
I6J81_RS14345	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6J81_RS14350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6J81_RS14355	COG3457	Alanine racemase
I6J81_RS14365	COG2188	Transcriptional regulator
I6J81_RS14370	COG0180	Tryptophanyl-tRNA synthetase
I6J81_RS14375	COG0546	phosphoglycolate phosphatase activity
I6J81_RS14380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J81_RS14385	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6J81_RS14390	COG3266	domain, Protein
I6J81_RS14405	COG4796	Type ii and iii secretion system protein
I6J81_RS14420	COG3166	PFAM Fimbrial assembly family protein
I6J81_RS14425	COG4972	Pilus assembly protein
I6J81_RS14430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J81_RS14435	COG0494	nUDIX hydrolase
I6J81_RS14445	COG1011	Hydrolase
I6J81_RS14450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J81_RS14460	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J81_RS14480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J81_RS14485	COG2183	response to ionizing radiation
I6J81_RS14490	COG1918	ferrous iron import across plasma membrane
I6J81_RS14495	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J81_RS14510	COG0596	Alpha beta hydrolase
I6J81_RS14525	COG2610	gluconate transmembrane transporter activity
I6J81_RS14530	COG1640	4-alpha-glucanotransferase
I6J81_RS14535	COG0058	SHG alpha-glucan phosphorylase activity
I6J81_RS14550	COG1690	Belongs to the RtcB family
I6J81_RS14555	COG4650	regulator
I6J81_RS14560	COG1349	DNA-binding transcription factor activity
I6J81_RS14575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J81_RS14615	COG3188	usher protein
I6J81_RS14620	COG3121	Chaperone
I6J81_RS14630	COG0058	SHG alpha-glucan phosphorylase activity
I6J81_RS14655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J81_RS14660	COG2095	MarC family integral membrane protein
I6J81_RS14665	COG2610	gluconate transmembrane transporter activity
I6J81_RS14670	COG3265	gluconokinase activity
I6J81_RS14675	COG1609	Transcriptional regulator
I6J81_RS14680	COG1741	Belongs to the pirin family
I6J81_RS14685	COG0673	inositol 2-dehydrogenase activity
I6J81_RS14690	COG1247	-acetyltransferase
I6J81_RS14695	COG3157	Type VI secretion system effector, Hcp
I6J81_RS14715	COG0405	Gamma-glutamyltransferase
I6J81_RS14725	COG0584	glycerophosphoryl diester phosphodiesterase
I6J81_RS14750	COG0410	ABC transporter
I6J81_RS14755	COG0411	ABC transporter
I6J81_RS14760	COG4177	L-phenylalanine transmembrane transporter activity
I6J81_RS14765	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS14770	COG0683	leucine binding
I6J81_RS14775	COG0456	acetyltransferase
I6J81_RS14780	COG0683	leucine binding
I6J81_RS14785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J81_RS14790	COG2177	Part of the ABC transporter FtsEX involved in
I6J81_RS14795	COG2884	Cell division ATP-binding protein ftsE
I6J81_RS14800	COG0552	protein localization to endoplasmic reticulum
I6J81_RS14805	COG0742	ribosomal rna small subunit methyltransferase
I6J81_RS14810	COG3776	membrane
I6J81_RS14820	COG3714	YhhN family
I6J81_RS14835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6J81_RS14845	COG0477	Major facilitator Superfamily
I6J81_RS14850	COG0628	permease
I6J81_RS14855	COG2091	lysine biosynthetic process via aminoadipic acid
I6J81_RS14860	COG0747	negative chemotaxis
I6J81_RS14865	COG0601	transmembrane transport
I6J81_RS14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J81_RS14890	COG2188	Transcriptional regulator
I6J81_RS14900	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J81_RS14905	COG3775	system Galactitol-specific IIC component
I6J81_RS14920	COG0191	fructose-bisphosphate aldolase activity
I6J81_RS14925	COG0842	Transport permease protein
I6J81_RS14930	COG0842	Transport permease protein
I6J81_RS14930	COG1129	ABC transporter
I6J81_RS14935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS14945	COG2081	HI0933 family
I6J81_RS14950	COG0306	phosphate transporter
I6J81_RS14960	COG0589	response to stress
I6J81_RS14965	COG3104	oligopeptide transport
I6J81_RS14975	COG0339	signal peptide processing
I6J81_RS14980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J81_RS14985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J81_RS14995	COG1393	Belongs to the ArsC family
I6J81_RS15005	COG3065	identical protein binding
I6J81_RS15010	COG2197	response regulator
I6J81_RS15015	COG3720	iron ion transport
I6J81_RS15020	COG4771	TonB-dependent receptor
I6J81_RS15035	COG3721	Heme iron utilization protein
I6J81_RS15045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS15055	COG1285	pathogenesis
I6J81_RS15070	COG3247	response to pH
I6J81_RS15075	COG2771	luxR family
I6J81_RS15085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS15090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J81_RS15095	COG2207	Transcriptional regulator
I6J81_RS15100	COG2207	Transcriptional regulator
I6J81_RS15105	COG0076	glutamate decarboxylase activity
I6J81_RS15110	COG1858	cytochrome C peroxidase
I6J81_RS15120	COG2197	response regulator
I6J81_RS15125	COG0583	DNA-binding transcription factor activity
I6J81_RS15130	COG1295	ribonuclease BN
I6J81_RS15135	COG0477	Major facilitator Superfamily
I6J81_RS15140	COG2982	Protein involved in outer membrane biogenesis
I6J81_RS15145	COG2200	EAL domain
I6J81_RS15150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS15155	COG0612	Peptidase, M16
I6J81_RS15165	COG2199	diguanylate cyclase activity
I6J81_RS15165	COG2200	EAL domain
I6J81_RS15170	COG3118	belongs to the thioredoxin family
I6J81_RS15170	COG0457	Tetratricopeptide repeat
I6J81_RS15175	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6J81_RS15180	COG1215	transferase activity, transferring glycosyl groups
I6J81_RS15185	COG1215	transferase activity, transferring glycosyl groups
I6J81_RS15210	COG2194	sulfuric ester hydrolase activity
I6J81_RS15220	COG0814	amino acid
I6J81_RS15225	COG4608	Belongs to the ABC transporter superfamily
I6J81_RS15230	COG0444	Belongs to the ABC transporter superfamily
I6J81_RS15235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J81_RS15240	COG0601	transmembrane transport
I6J81_RS15250	COG0747	negative chemotaxis
I6J81_RS15260	COG2194	sulfuric ester hydrolase activity
I6J81_RS15265	COG2223	nitrite transmembrane transporter activity
I6J81_RS15270	COG5571	outer membrane autotransporter
I6J81_RS15275	COG2818	Glycosylase
I6J81_RS15280	COG0456	acetyltransferase
I6J81_RS15285	COG0243	molybdopterin cofactor binding
I6J81_RS15290	COG2885	chlorophyll binding
I6J81_RS15305	COG2944	sequence-specific DNA binding
I6J81_RS15310	COG1278	Cold shock
I6J81_RS15335	COG3274	enterobacterial common antigen metabolic process
I6J81_RS15340	COG4682	membrane
I6J81_RS15345	COG4682	membrane
I6J81_RS15350	COG1070	Carbohydrate kinase
I6J81_RS15360	COG4213	ABC transporter substrate-binding protein
I6J81_RS15370	COG4214	carbohydrate transport
I6J81_RS15375	COG2207	Transcriptional regulator
I6J81_RS15375	COG1609	Transcriptional regulator
I6J81_RS15380	COG2992	FlgJ-related protein
I6J81_RS15385	COG0366	Alpha amylase catalytic
I6J81_RS15390	COG3977	Valine--pyruvate aminotransferase
I6J81_RS15395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J81_RS15400	COG1414	Transcriptional regulator
I6J81_RS15410	COG2731	YhcH YjgK YiaL family protein
I6J81_RS15420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6J81_RS15425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6J81_RS15430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6J81_RS15435	COG1070	Carbohydrate kinase
I6J81_RS15440	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6J81_RS15445	COG3623	hexulose-6-phosphate isomerase
I6J81_RS15450	COG0235	Class ii aldolase
I6J81_RS15455	COG1012	belongs to the aldehyde dehydrogenase family
I6J81_RS15465	COG1454	alcohol dehydrogenase
I6J81_RS15470	COG3276	selenocysteine insertion sequence binding
I6J81_RS15480	COG0625	glutathione transferase activity
I6J81_RS15485	COG1566	PFAM secretion protein HlyD family protein
I6J81_RS15495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS15495	COG2213	PTS system mannitol-specific
I6J81_RS15505	COG3722	fumarate hydratase activity
I6J81_RS15525	COG5295	Hep Hag repeat protein
I6J81_RS15530	COG1620	l-lactate permease
I6J81_RS15535	COG2186	Transcriptional regulator
I6J81_RS15545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J81_RS15550	COG1045	serine acetyltransferase
I6J81_RS15565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J81_RS15570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J81_RS15580	COG4942	peptidase
I6J81_RS15585	COG2861	carbohydrate metabolic process
I6J81_RS15590	COG1216	Glycosyl transferase, family 2
I6J81_RS15600	COG0156	8-amino-7-oxononanoate synthase activity
I6J81_RS15610	COG0859	PFAM glycosyl transferase family 9
I6J81_RS15615	COG0859	PFAM glycosyl transferase family 9
I6J81_RS15620	COG3307	-O-antigen
I6J81_RS15625	COG1216	Glycosyl transferase, family 2
I6J81_RS15630	COG1442	glycosyl transferase family 8
I6J81_RS15635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J81_RS15650	COG0515	serine threonine protein kinase
I6J81_RS15655	COG0438	transferase activity, transferring glycosyl groups
I6J81_RS15660	COG0859	PFAM glycosyl transferase family 9
I6J81_RS15665	COG1519	Transferase
I6J81_RS15695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J81_RS15720	COG1561	YicC-like family, N-terminal region
I6J81_RS15725	COG3645	SOS response
I6J81_RS15730	COG2860	membrane
I6J81_RS15740	COG0194	GDP metabolic process
I6J81_RS15750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J81_RS15755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J81_RS15760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J81_RS15765	COG0786	glutamate:sodium symporter activity
I6J81_RS15770	COG2233	PERMEase
I6J81_RS15775	COG2982	Protein involved in outer membrane biogenesis
I6J81_RS15785	COG1940	carbohydrate kinase activity
I6J81_RS15800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS15800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS15805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS15810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS15810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS15810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS15815	COG3711	transcriptional antiterminator
I6J81_RS15820	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J81_RS15825	COG2211	Major facilitator Superfamily
I6J81_RS15835	COG0582	viral genome integration into host DNA
I6J81_RS15945	COG0697	spore germination
I6J81_RS15955	COG2433	Pfam Transposase IS66
I6J81_RS15980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6J81_RS15990	COG4772	TonB-dependent receptor
I6J81_RS15995	COG1595	DNA-templated transcription, initiation
I6J81_RS16040	COG3596	GTP binding
I6J81_RS16045	COG2378	regulation of single-species biofilm formation
I6J81_RS16070	COG2003	Belongs to the UPF0758 family
I6J81_RS16115	COG0697	spore germination
I6J81_RS16120	COG1464	Belongs to the NlpA lipoprotein family
I6J81_RS16140	COG2252	PERMEase
I6J81_RS16150	COG2271	Major facilitator Superfamily
I6J81_RS16155	COG2271	Major facilitator Superfamily
I6J81_RS16160	COG3851	Histidine kinase
I6J81_RS16165	COG2197	response regulator
I6J81_RS16175	COG0440	acetolactate synthase activity
I6J81_RS16180	COG0028	Belongs to the TPP enzyme family
I6J81_RS16190	COG2814	Major facilitator Superfamily
I6J81_RS16195	COG0641	radical SAM
I6J81_RS16205	COG2149	membrane
I6J81_RS16210	COG3119	arylsulfatase activity
I6J81_RS16215	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J81_RS16220	COG2207	Transcriptional regulator
I6J81_RS16240	COG5645	(Lipo)protein
I6J81_RS16245	COG0823	Involved in the tonB-independent uptake of proteins
I6J81_RS16250	COG0644	oxidoreductase
I6J81_RS16255	COG2271	Major facilitator Superfamily
I6J81_RS16265	COG0800	Aldolase
I6J81_RS16270	COG3734	2-keto-3-deoxy-galactonokinase
I6J81_RS16275	COG2186	Transcriptional regulator
I6J81_RS16285	COG0561	phosphatase activity
I6J81_RS16290	COG3753	Protein conserved in bacteria
I6J81_RS16295	COG0187	DNA topoisomerase II activity
I6J81_RS16305	COG0592	DNA-directed DNA polymerase activity
I6J81_RS16355	COG0814	amino acid
I6J81_RS16365	COG0583	DNA-binding transcription factor activity
I6J81_RS16370	COG2091	lysine biosynthetic process via aminoadipic acid
I6J81_RS16375	COG0431	NADPH-dependent FMN reductase
I6J81_RS16380	COG2252	PERMEase
I6J81_RS16385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J81_RS16395	COG0363	glucosamine-6-phosphate deaminase activity
I6J81_RS16400	COG2382	esterase
I6J81_RS16405	COG4580	involved in the transport of maltose and maltodextrins
I6J81_RS16410	COG2723	6-phospho-beta-galactosidase activity
I6J81_RS16415	COG1263	PTS System
I6J81_RS16415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS16415	COG2190	(PTS) system
I6J81_RS16420	COG3711	transcriptional antiterminator
I6J81_RS16425	COG0704	Plays a role in the regulation of phosphate uptake
I6J81_RS16430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J81_RS16435	COG0581	inorganic phosphate transmembrane transporter activity
I6J81_RS16440	COG0573	inorganic phosphate transmembrane transporter activity
I6J81_RS16445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J81_RS16500	COG3312	ion transport
I6J81_RS16515	COG0716	FMN binding
I6J81_RS16520	COG1522	sequence-specific DNA binding
I6J81_RS16550	COG1129	ABC transporter
I6J81_RS16555	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS16560	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS16565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS16570	COG1609	Transcriptional regulator
I6J81_RS16575	COG0477	Major facilitator Superfamily
I6J81_RS16580	COG2186	Transcriptional regulator
I6J81_RS16620	COG3085	chromosome segregation
I6J81_RS16625	COG0606	chelatase, subunit chli
I6J81_RS16645	COG3978	acetolactate synthase activity
I6J81_RS16650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J81_RS16660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J81_RS16665	COG0583	DNA-binding transcription factor activity
I6J81_RS16675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J81_RS16680	COG0210	DNA helicase
I6J81_RS16695	COG3118	belongs to the thioredoxin family
I6J81_RS16705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J81_RS16710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J81_RS16715	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J81_RS16720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J81_RS16725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J81_RS16730	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J81_RS16735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J81_RS16740	COG0456	acetyltransferase
I6J81_RS16745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J81_RS16750	COG2244	polysaccharide biosynthetic process
I6J81_RS16755	COG1819	glycosyl
I6J81_RS16770	COG1113	amino acid transport
I6J81_RS16795	COG0641	radical SAM
I6J81_RS16800	COG3119	arylsulfatase activity
I6J81_RS16815	COG3071	HemY protein
I6J81_RS16820	COG2959	enzyme of heme biosynthesis
I6J81_RS16825	COG1587	Uroporphyrinogen-III synthase
I6J81_RS16830	COG0181	hydroxymethylbilane synthase activity
I6J81_RS16835	COG3072	Adenylate cyclase
I6J81_RS16855	COG5567	small periplasmic lipoprotein
I6J81_RS16865	COG3159	Protein conserved in bacteria
I6J81_RS16875	COG1011	Hydrolase
I6J81_RS16880	COG0210	DNA helicase
I6J81_RS16885	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6J81_RS16890	COG3698	Phosphodiester glycosidase
I6J81_RS16895	COG0598	Magnesium transport protein CorA
I6J81_RS16910	COG2962	Rard protein
I6J81_RS16915	COG2050	protein possibly involved in aromatic compounds catabolism
I6J81_RS16920	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6J81_RS16925	COG0514	ATP-dependent DNA helicase (RecQ)
I6J81_RS16930	COG1280	lysine exporter protein (LysE YggA)
I6J81_RS16935	COG1280	lysine exporter protein (LysE YggA)
I6J81_RS16940	COG2267	carboxylic ester hydrolase activity
I6J81_RS16945	COG0561	phosphatase activity
I6J81_RS16950	COG0697	spore germination
I6J81_RS16955	COG0583	DNA-binding transcription factor activity
I6J81_RS16960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J81_RS16970	COG3157	Type VI secretion system effector, Hcp
I6J81_RS16975	COG3157	Type VI secretion system effector, Hcp
I6J81_RS16985	COG1263	PTS System
I6J81_RS16985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS16985	COG2190	(PTS) system
I6J81_RS16990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J81_RS16995	COG1737	Transcriptional regulator
I6J81_RS17000	COG0583	DNA-binding transcription factor activity
I6J81_RS17005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J81_RS17015	COG0549	Belongs to the carbamate kinase family
I6J81_RS17020	COG1304	FMN binding
I6J81_RS17025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J81_RS17035	COG1335	isochorismatase
I6J81_RS17040	COG0412	Dienelactone hydrolase
I6J81_RS17045	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6J81_RS17065	COG0800	Aldolase
I6J81_RS17070	COG3734	2-keto-3-deoxy-galactonokinase
I6J81_RS17075	COG1414	Transcriptional regulator
I6J81_RS17080	COG1322	Protein conserved in bacteria
I6J81_RS17090	COG3165	ubiquinone biosynthetic process from chorismate
I6J81_RS17100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J81_RS17110	COG0805	protein transport
I6J81_RS17125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J81_RS17130	COG0543	2 iron, 2 sulfur cluster binding
I6J81_RS17150	COG1739	Uncharacterized protein family UPF0029
I6J81_RS17155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J81_RS17160	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6J81_RS17190	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6J81_RS17195	COG0746	molybdenum cofactor guanylyltransferase activity
I6J81_RS17200	COG3084	Protein conserved in bacteria
I6J81_RS17205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J81_RS17210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J81_RS17215	COG5339	Protein conserved in bacteria
I6J81_RS17220	COG0204	Acyl-transferase
I6J81_RS17225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J81_RS17225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J81_RS17240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J81_RS17250	COG2204	response regulator
I6J81_RS17255	COG3852	Histidine kinase
I6J81_RS17260	COG0174	glutamine synthetase
I6J81_RS17265	COG1217	gtp-binding protein TYPA
I6J81_RS17270	COG1349	DNA-binding transcription factor activity
I6J81_RS17275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS17280	COG2084	Dehydrogenase
I6J81_RS17285	COG3684	Belongs to the aldolase LacD family
I6J81_RS17290	COG1063	alcohol dehydrogenase
I6J81_RS17300	COG0477	Major facilitator Superfamily
I6J81_RS17310	COG1011	Hydrolase
I6J81_RS17325	COG0456	acetyltransferase
I6J81_RS17335	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6J81_RS17360	COG2864	formate dehydrogenase
I6J81_RS17365	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS17425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J81_RS17435	COG2258	MOSC domain
I6J81_RS17440	COG2205	protein histidine kinase activity
I6J81_RS17445	COG0745	RESPONSE REGULATOR receiver
I6J81_RS17450	COG3678	ATP-independent chaperone mediated protein folding
I6J81_RS17465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J81_RS17485	COG3152	Membrane
I6J81_RS17490	COG3691	Protein conserved in bacteria
I6J81_RS17495	COG0589	response to stress
I6J81_RS17505	COG1494	fructose-1,6-bisphosphatase
I6J81_RS17515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J81_RS17530	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J81_RS17545	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J81_RS17550	COG1609	Transcriptional regulator
I6J81_RS17555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J81_RS17565	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6J81_RS17575	COG0626	cystathionine gamma-synthase activity
I6J81_RS17580	COG0527	aspartate kinase activity
I6J81_RS17580	COG0460	homoserine dehydrogenase
I6J81_RS17590	COG0737	Belongs to the 5'-nucleotidase family
I6J81_RS17595	COG0737	Belongs to the 5'-nucleotidase family
I6J81_RS17605	COG0737	Belongs to the 5'-nucleotidase family
I6J81_RS17610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J81_RS17620	COG0697	spore germination
I6J81_RS17625	COG3738	Protein conserved in bacteria
I6J81_RS17630	COG0371	Dehydrogenase
I6J81_RS17635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J81_RS17640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J81_RS17640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS17640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS17645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS17650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS17655	COG1882	Formate acetyltransferase
I6J81_RS17660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J81_RS17665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J81_RS17670	COG2207	Transcriptional regulator
I6J81_RS17675	COG2194	sulfuric ester hydrolase activity
I6J81_RS17690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J81_RS17695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J81_RS17705	COG4948	Mandelate Racemase Muconate Lactonizing
I6J81_RS17710	COG2271	Major facilitator Superfamily
I6J81_RS17715	COG0583	DNA-binding transcription factor activity
I6J81_RS17725	COG1473	amidohydrolase
I6J81_RS17730	COG0477	Major facilitator Superfamily
I6J81_RS17780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J81_RS17785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J81_RS17785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J81_RS17820	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J81_RS17825	COG0250	Participates in transcription elongation, termination and antitermination
I6J81_RS17860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J81_RS17870	COG2104	thiamine diphosphate biosynthetic process
I6J81_RS17875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J81_RS17910	COG3068	Protein conserved in bacteria
I6J81_RS17925	COG3678	ATP-independent chaperone mediated protein folding
I6J81_RS17930	COG4191	Histidine kinase
I6J81_RS17935	COG2204	response regulator
I6J81_RS17940	COG0151	Belongs to the GarS family
I6J81_RS17945	COG0138	bifunctional purine biosynthesis protein purh
I6J81_RS17975	COG0456	acetyltransferase
I6J81_RS17985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J81_RS17990	COG2224	Isocitrate lyase
I6J81_RS18000	COG1414	Transcriptional regulator
I6J81_RS18005	COG1410	methionine synthase
I6J81_RS18005	COG0646	methionine synthase
I6J81_RS18020	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J81_RS18065	COG1187	pseudouridine synthase activity
I6J81_RS18075	COG0527	aspartate kinase activity
I6J81_RS18100	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J81_RS18115	COG3833	ABC-type maltose transport systems, permease component
I6J81_RS18120	COG1175	transmembrane transport
I6J81_RS18125	COG2182	Extracellular solute-binding protein
I6J81_RS18130	COG3842	ATPase activity
I6J81_RS18160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J81_RS18170	COG0534	Mate efflux family protein
I6J81_RS18175	COG3237	CsbD-like
I6J81_RS18180	COG0735	belongs to the Fur family
I6J81_RS18185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J81_RS18195	COG0604	alcohol dehydrogenase
I6J81_RS18200	COG0305	Participates in initiation and elongation during chromosome replication
I6J81_RS18205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J81_RS18210	COG1448	Aminotransferase
I6J81_RS18215	COG0567	Dehydrogenase, E1 component
I6J81_RS18225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J81_RS18230	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J81_RS18235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J81_RS18240	COG0471	metal ion transport
I6J81_RS18245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J81_RS18250	COG2204	response regulator
I6J81_RS18260	COG3700	Belongs to the class B bacterial acid phosphatase family
I6J81_RS18265	COG0432	Pfam Uncharacterised protein family UPF0047
I6J81_RS18270	COG2315	Protein conserved in bacteria
I6J81_RS18275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J81_RS18280	COG0629	single-stranded DNA binding
I6J81_RS18290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6J81_RS18295	COG2207	Transcriptional regulator
I6J81_RS18300	COG0789	Transcriptional regulator
I6J81_RS18305	COG2252	PERMEase
I6J81_RS18310	COG0025	NhaP-type Na H and K H
I6J81_RS18315	COG0583	DNA-binding transcription factor activity
I6J81_RS18320	COG1380	Effector of murein hydrolase LrgA
I6J81_RS18325	COG1346	cytolysis
I6J81_RS18335	COG3162	membrane
I6J81_RS18340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J81_RS18350	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J81_RS18355	COG0437	4 iron, 4 sulfur cluster binding
I6J81_RS18360	COG3301	Polysulphide reductase, NrfD
I6J81_RS18365	COG1138	Cytochrome C-type biogenesis protein
I6J81_RS18370	COG3088	subunit of a heme lyase
I6J81_RS18375	COG4235	cytochrome complex assembly
I6J81_RS18380	COG1301	dicarboxylic acid transport
I6J81_RS18385	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6J81_RS18390	COG4608	Belongs to the ABC transporter superfamily
I6J81_RS18395	COG0444	Belongs to the ABC transporter superfamily
I6J81_RS18400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J81_RS18405	COG0601	transmembrane transport
I6J81_RS18425	COG1289	transmembrane transporter activity
I6J81_RS18430	COG1566	PFAM secretion protein HlyD family protein
I6J81_RS18440	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J81_RS18445	COG1940	carbohydrate kinase activity
I6J81_RS18450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J81_RS18455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS18460	COG1129	ABC transporter
I6J81_RS18465	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS18470	COG1737	Transcriptional regulator
I6J81_RS18475	COG0698	ribose 5-phosphate isomerase
I6J81_RS18485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J81_RS18490	COG0456	acetyltransferase
I6J81_RS18495	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6J81_RS18500	COG3454	Phosphonate metabolism
I6J81_RS18505	COG4778	phosphonate C-P lyase system protein PhnL
I6J81_RS18510	COG4107	phosphonate C-P lyase system protein PhnK
I6J81_RS18515	COG3627	carbon phosphorus lyase activity
I6J81_RS18520	COG3626	phosphonate metabolism
I6J81_RS18525	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6J81_RS18530	COG3624	Phosphonate C-P lyase system protein PhnG
I6J81_RS18535	COG2188	Transcriptional regulator
I6J81_RS18540	COG3639	organic phosphonate transmembrane transporter activity
I6J81_RS18545	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6J81_RS18555	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6J81_RS18560	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J81_RS18575	COG0477	Major facilitator Superfamily
I6J81_RS18585	COG0642	Histidine kinase
I6J81_RS18590	COG0745	RESPONSE REGULATOR receiver
I6J81_RS18595	COG2194	sulfuric ester hydrolase activity
I6J81_RS18600	COG0531	amino acid
I6J81_RS18605	COG2207	Transcriptional regulator
I6J81_RS18610	COG1982	Orn Lys Arg decarboxylase major
I6J81_RS18615	COG2169	Transcriptional regulator
I6J81_RS18620	COG1486	melibiose metabolic process
I6J81_RS18625	COG3647	Membrane
I6J81_RS18630	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J81_RS18630	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J81_RS18635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J81_RS18640	COG4565	transcriptional regulatory protein
I6J81_RS18645	COG3290	protein histidine kinase activity
I6J81_RS18650	COG3592	Divergent 4Fe-4S mono-cluster
I6J81_RS18655	COG2388	GCN5-related N-acetyl-transferase
I6J81_RS18670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J81_RS18675	COG3104	oligopeptide transport
I6J81_RS18680	COG1982	Orn Lys Arg decarboxylase major
I6J81_RS18685	COG0531	amino acid
I6J81_RS18690	COG3710	Transcriptional regulator
I6J81_RS18695	COG2771	luxR family
I6J81_RS18695	COG2200	EAL domain
I6J81_RS18735	COG2003	Belongs to the UPF0758 family
I6J81_RS18760	COG2378	regulation of single-species biofilm formation
I6J81_RS18765	COG3596	GTP binding
I6J81_RS18800	COG1349	DNA-binding transcription factor activity
I6J81_RS18810	COG0738	Major facilitator superfamily
I6J81_RS18820	COG2259	Doxx family
I6J81_RS18850	COG3436	PFAM IS66 Orf2 family protein
I6J81_RS18920	COG2801	Transposase and inactivated derivatives
I6J81_RS18945	COG4774	siderophore transport
I6J81_RS18945	COG1629	transport
I6J81_RS18950	COG3391	amine dehydrogenase activity
I6J81_RS19010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6J81_RS19020	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J81_RS19030	COG0583	DNA-binding transcription factor activity
I6J81_RS19065	COG3969	phosphoadenosine phosphosulfate
I6J81_RS19070	COG1475	DNA binding
I6J81_RS19085	COG1741	Belongs to the pirin family
I6J81_RS19090	COG3619	membrane
I6J81_RS19095	COG2207	Transcriptional regulator
I6J81_RS19100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J81_RS19115	COG3436	PFAM IS66 Orf2 family protein
I6J81_RS19145	COG4774	siderophore transport
I6J81_RS19145	COG1629	transport
I6J81_RS19150	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS19155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS19160	COG4592	Periplasmic binding protein
I6J81_RS19165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J81_RS19175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J81_RS19235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J81_RS19270	COG0582	viral genome integration into host DNA
I6J81_RS19280	COG2194	sulfuric ester hydrolase activity
I6J81_RS19290	COG0582	viral genome integration into host DNA
I6J81_RS19300	COG1309	transcriptional regulator
I6J81_RS19305	COG4232	protein-disulfide reductase activity
I6J81_RS19315	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J81_RS19320	COG1027	Aspartate ammonia-lyase
I6J81_RS19325	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6J81_RS19330	COG0531	amino acid
I6J81_RS19355	COG1509	lysine 2,3-aminomutase activity
I6J81_RS19365	COG5510	response to toxic substance
I6J81_RS19370	COG5510	response to toxic substance
I6J81_RS19375	COG2076	Multidrug Resistance protein
I6J81_RS19380	COG3040	lipid binding
I6J81_RS19385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J81_RS19400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J81_RS19405	COG1053	succinate dehydrogenase
I6J81_RS19415	COG0531	amino acid
I6J81_RS19420	COG1511	domain protein
I6J81_RS19420	COG3264	Mechanosensitive ion channel
I6J81_RS19460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J81_RS19465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J81_RS19465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J81_RS19470	COG0802	atpase or kinase
I6J81_RS19475	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J81_RS19495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J81_RS19500	COG0330	HflC and HflK could
I6J81_RS19505	COG0330	HflC and HflK could
I6J81_RS19510	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6J81_RS19525	COG0557	exoribonuclease II activity
I6J81_RS19530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J81_RS19535	COG3789	protein conserved in bacteria
I6J81_RS19540	COG1842	Phage shock protein A
I6J81_RS19550	COG3766	membrane
I6J81_RS19555	COG5463	Belongs to the UPF0441 family
I6J81_RS19560	COG0754	glutathionylspermidine amidase activity
I6J81_RS19565	COG1960	acyl-CoA dehydrogenase activity
I6J81_RS19575	COG3650	response to hydrogen peroxide
I6J81_RS19580	COG1073	alpha beta
I6J81_RS19595	COG3037	sugar-specific permease SgaT UlaA
I6J81_RS19600	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J81_RS19640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J81_RS19660	COG2271	Major facilitator Superfamily
I6J81_RS19665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J81_RS19670	COG4670	ketone body catabolic process
I6J81_RS19675	COG1024	Enoyl-CoA hydratase
I6J81_RS19690	COG1309	transcriptional regulator
I6J81_RS19695	COG3061	Opacity-associated protein A
I6J81_RS19700	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J81_RS19705	COG1113	amino acid transport
I6J81_RS19715	COG0697	spore germination
I6J81_RS19720	COG0702	epimerase
I6J81_RS19725	COG1733	regulation of RNA biosynthetic process
I6J81_RS19735	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6J81_RS19740	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6J81_RS19750	COG1253	flavin adenine dinucleotide binding
I6J81_RS19760	COG0729	surface antigen
I6J81_RS19765	COG2911	Protein conserved in bacteria
I6J81_RS19770	COG2105	PFAM AIG2 family protein
I6J81_RS19775	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6J81_RS19780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J81_RS19785	COG1879	ABC-type sugar transport system periplasmic component
I6J81_RS19790	COG1129	ABC transporter
I6J81_RS19795	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS19800	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J81_RS19810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J81_RS19815	COG3028	Belongs to the UPF0307 family
I6J81_RS19820	COG0312	modulator of DNA gyrase
I6J81_RS19825	COG3783	Cytochrome b(562)
I6J81_RS19830	COG0602	queuosine metabolic process
I6J81_RS19835	COG1328	CTP reductase activity
I6J81_RS19840	COG0366	Alpha amylase catalytic
I6J81_RS19845	COG1263	PTS System
I6J81_RS19845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS19850	COG1609	Transcriptional regulator
I6J81_RS19860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J81_RS19865	COG0251	oxidation-reduction process
I6J81_RS19885	COG1438	arginine binding
I6J81_RS19890	COG1288	antiporter activity
I6J81_RS19895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J81_RS19900	COG0549	Belongs to the carbamate kinase family
I6J81_RS19910	COG2731	YhcH YjgK YiaL family protein
I6J81_RS19915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J81_RS19920	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6J81_RS19925	COG0456	acetyltransferase
I6J81_RS19935	COG0525	valine-tRNA ligase activity
I6J81_RS19940	COG2927	DNA polymerase III (CHI subunit)
I6J81_RS19950	COG0795	lipopolysaccharide-transporting ATPase activity
I6J81_RS19955	COG0795	lipopolysaccharide-transporting ATPase activity
I6J81_RS19960	COG0433	COG0433 Predicted ATPase
I6J81_RS19965	COG1064	alcohol dehydrogenase
I6J81_RS19985	COG3547	Transposase (IS116 IS110 IS902 family)
I6J81_RS20005	COG1401	restriction endodeoxyribonuclease activity
I6J81_RS20035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6J81_RS20040	COG0582	viral genome integration into host DNA
I6J81_RS20045	COG4974	Belongs to the 'phage' integrase family
I6J81_RS20050	COG3539	Fimbrial protein
I6J81_RS20055	COG3539	Fimbrial protein
I6J81_RS20060	COG3121	Chaperone
I6J81_RS20065	COG3188	usher protein
I6J81_RS20070	COG3539	Fimbrial protein
I6J81_RS20075	COG3539	Fimbrial protein
I6J81_RS20080	COG3539	Fimbrial protein
I6J81_RS20095	COG0246	Mannitol dehydrogenase
I6J81_RS20100	COG2186	Transcriptional regulator
I6J81_RS20110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J81_RS20110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS20115	COG1461	Dihydroxyacetone kinase
I6J81_RS20120	COG2376	Dihydroxyacetone kinase
I6J81_RS20135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J81_RS20145	COG1929	Belongs to the glycerate kinase type-1 family
I6J81_RS20150	COG2084	Dehydrogenase
I6J81_RS20155	COG3622	Belongs to the hyi family
I6J81_RS20160	COG3960	tartronate-semialdehyde synthase activity
I6J81_RS20165	COG3284	Transcriptional regulator
I6J81_RS20175	COG1757	Na H antiporter
I6J81_RS20180	COG0583	DNA-binding transcription factor activity
I6J81_RS20185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J81_RS20190	COG0700	Nucleoside recognition
I6J81_RS20195	COG3366	ferrous iron transmembrane transporter activity
I6J81_RS20205	COG0477	Major facilitator Superfamily
I6J81_RS20220	COG1924	4 iron, 4 sulfur cluster binding
I6J81_RS20225	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6J81_RS20230	COG2733	membrane
I6J81_RS20240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J81_RS20245	COG5457	Domain of unknown function (DUF1127)
I6J81_RS20255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J81_RS20260	COG0732	type I restriction modification DNA specificity domain
I6J81_RS20265	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J81_RS20270	COG1715	Restriction endonuclease
I6J81_RS20285	COG0523	cobalamin synthesis protein
I6J81_RS20290	COG2879	small protein
I6J81_RS20295	COG1966	Carbon starvation protein
I6J81_RS20300	COG0840	transmembrane signaling receptor activity
I6J81_RS20305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6J81_RS20315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6J81_RS20320	COG0025	NhaP-type Na H and K H
I6J81_RS20325	COG1802	Transcriptional regulator
I6J81_RS20330	COG1063	alcohol dehydrogenase
I6J81_RS20345	COG1484	DNA-dependent DNA replication
I6J81_RS20360	COG2966	Psort location CytoplasmicMembrane, score
I6J81_RS20365	COG2197	response regulator
I6J81_RS20370	COG2197	response regulator
I6J81_RS20375	COG4114	ferric iron reductase
I6J81_RS20405	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6J81_RS20410	COG0456	acetyltransferase
I6J81_RS20415	COG1011	Hydrolase
I6J81_RS20425	COG2823	Periplasmic or secreted lipoprotein
I6J81_RS20435	COG4667	esterase of the alpha-beta hydrolase superfamily
I6J81_RS20440	COG0084	hydrolase, TatD family'
I6J81_RS20450	COG1328	CTP reductase activity
I6J81_RS20475	COG3550	peptidyl-serine autophosphorylation
I6J81_RS20485	COG3726	membrane protein affecting hemolysin expression
I6J81_RS20490	COG0560	Phosphoserine phosphatase
I6J81_RS20495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J81_RS20500	COG1056	cytidyltransferase-related domain
I6J81_RS20500	COG3172	ATPase kinase involved in NAD metabolism
I6J81_RS20505	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6J81_RS20515	COG0488	(ABC) transporter
I6J81_RS20520	COG0741	lytic transglycosylase activity
I6J81_RS20540	COG3708	Transcriptional regulator
I6J81_RS20540	COG2207	Transcriptional regulator
I6J81_RS20545	COG3045	CreA protein
I6J81_RS20550	COG0745	RESPONSE REGULATOR receiver
I6J81_RS20555	COG2205	protein histidine kinase activity
I6J81_RS20560	COG4452	Inner membrane protein CreD
I6J81_RS20565	COG0745	RESPONSE REGULATOR receiver
I6J81_RS20575	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6J81_RS20585	COG0460	homoserine dehydrogenase
I6J81_RS20585	COG0527	aspartate kinase activity
I6J81_RS20590	COG0083	homoserine kinase activity
I6J81_RS20595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J81_RS20610	COG1115	amino acid carrier protein
I6J81_RS20620	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J81_RS20625	COG1584	GPR1 FUN34 yaaH family protein
I6J81_RS20630	COG4735	regulation of single-species biofilm formation
I6J81_RS20660	COG3119	arylsulfatase activity
I6J81_RS20675	COG0583	DNA-binding transcription factor activity
I6J81_RS20690	COG0196	riboflavin kinase activity
I6J81_RS20705	COG1047	Peptidyl-prolyl cis-trans
I6J81_RS20730	COG0505	Belongs to the CarA family
I6J81_RS20735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J81_RS20785	COG0644	oxidoreductase
I6J81_RS20790	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J81_RS20795	COG2271	Major facilitator Superfamily
I6J81_RS20810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J81_RS20840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J81_RS20845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J81_RS20855	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6J81_RS20860	COG0564	pseudouridine synthase activity
I6J81_RS20870	COG0417	DNA replication proofreading
I6J81_RS20875	COG0235	Class ii aldolase
I6J81_RS20890	COG4977	sequence-specific DNA binding
I6J81_RS20905	COG0586	Pfam SNARE associated Golgi protein
I6J81_RS20915	COG1178	ABC-type Fe3 transport system permease component
I6J81_RS20920	COG4143	(ABC) transporter
I6J81_RS20960	COG0583	DNA-binding transcription factor activity
I6J81_RS20970	COG0028	Belongs to the TPP enzyme family
I6J81_RS20975	COG0440	acetolactate synthase activity
I6J81_RS20985	COG1609	Transcriptional regulator
I6J81_RS21000	COG3116	cell division
I6J81_RS21005	COG0768	penicillin binding
I6J81_RS21010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J81_RS21015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J81_RS21030	COG0772	Belongs to the SEDS family
I6J81_RS21045	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J81_RS21050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J81_RS21055	COG0849	cell division
I6J81_RS21060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J81_RS21080	COG0494	nUDIX hydrolase
I6J81_RS21095	COG0237	dephospho-CoA kinase activity
I6J81_RS21110	COG1459	type II secretion system
I6J81_RS21115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J81_RS21120	COG4969	Belongs to the N-Me-Phe pilin family
I6J81_RS21125	COG0157	Belongs to the NadC ModD family
I6J81_RS21130	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J81_RS21135	COG3725	Membrane protein required for beta-lactamase induction
I6J81_RS21140	COG1113	amino acid transport
I6J81_RS21145	COG3157	Type VI secretion system effector, Hcp
I6J81_RS21175	COG2186	Transcriptional regulator
I6J81_RS21180	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J81_RS21185	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J81_RS21190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J81_RS21195	COG3064	Membrane
I6J81_RS21200	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6J81_RS21225	COG2132	Multicopper oxidase
I6J81_RS21230	COG4993	Dehydrogenase
I6J81_RS21235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J81_RS21240	COG0288	reversible hydration of carbon dioxide
I6J81_RS21245	COG1131	(ABC) transporter
I6J81_RS21250	COG0842	Transport permease protein
I6J81_RS21255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J81_RS21260	COG0726	polysaccharide deacetylase
I6J81_RS21270	COG5464	transposase or invertase
I6J81_RS21275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J81_RS21285	COG3539	Fimbrial protein
I6J81_RS21290	COG3539	Fimbrial protein
I6J81_RS21295	COG3539	Fimbrial protein
I6J81_RS21300	COG3539	Fimbrial protein
I6J81_RS21305	COG3188	usher protein
I6J81_RS21310	COG3121	Chaperone
I6J81_RS21315	COG3539	Fimbrial protein
I6J81_RS21320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J81_RS21325	COG0617	tRNA 3'-terminal CCA addition
I6J81_RS21330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J81_RS21335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J81_RS21345	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6J81_RS21350	COG1643	Atp-dependent helicase
I6J81_RS21355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J81_RS21360	COG4774	siderophore transport
I6J81_RS21365	COG1120	ATPase activity
I6J81_RS21370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J81_RS21375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS21400	COG2860	membrane
I6J81_RS21405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J81_RS21420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J81_RS21425	COG3835	regulator
I6J81_RS21445	COG0024	Methionine aminopeptidase
I6J81_RS21470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J81_RS21475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J81_RS21480	COG0575	Belongs to the CDS family
I6J81_RS21485	COG0750	zinc metalloprotease
I6J81_RS21495	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6J81_RS21500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J81_RS21525	COG0587	DNA-directed DNA polymerase activity
I6J81_RS21535	COG1982	Orn Lys Arg decarboxylase major
I6J81_RS21540	COG0346	lactoylglutathione lyase activity
I6J81_RS21545	COG0037	tRNA processing
I6J81_RS21550	COG4568	rho-dependent transcription termination
I6J81_RS21560	COG4681	YaeQ
I6J81_RS21565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J81_RS21570	COG3015	lipoprotein NlpE involved in copper resistance
I6J81_RS21575	COG0791	NLP P60 protein
I6J81_RS21585	COG1720	tRNA m6t6A37 methyltransferase activity
I6J81_RS21595	COG1464	Belongs to the NlpA lipoprotein family
I6J81_RS21600	COG2011	ABC-type metal ion transport system permease component
I6J81_RS21605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J81_RS21610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J81_RS21645	COG0656	L-ascorbic acid biosynthetic process
I6J81_RS21650	COG0583	DNA-binding transcription factor activity
I6J81_RS21660	COG2226	methyltransferase
I6J81_RS21665	COG1388	LysM domain
I6J81_RS21665	COG0741	lytic transglycosylase activity
I6J81_RS21675	COG2226	methyltransferase
I6J81_RS21685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J81_RS21780	COG3501	Rhs element vgr protein
I6J81_RS21830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J81_RS21840	COG1960	acyl-CoA dehydrogenase activity
I6J81_RS21850	COG0121	glutamine amidotransferase
I6J81_RS21855	COG3034	peptidoglycan biosynthetic process
I6J81_RS21860	COG0791	NLP P60 protein
I6J81_RS21865	COG1943	Transposase
I6J81_RS21890	COG1987	bacterial-type flagellum assembly
I6J81_RS21915	COG1677	Flagellar hook-basal body complex protein FliE
I6J81_RS21925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J81_RS21945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J81_RS21960	COG0463	Glycosyl transferase, family 2
I6J81_RS21985	COG1815	bacterial-type flagellum-dependent cell motility
I6J81_RS21990	COG1558	bacterial-type flagellum-dependent cell motility
I6J81_RS22000	COG1749	Flagellar hook protein flgE
I6J81_RS22005	COG4787	bacterial-type flagellum-dependent cell motility
I6J81_RS22010	COG4786	Flagellar basal body rod
I6J81_RS22035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J81_RS22050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J81_RS22055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6J81_RS22080	COG1191	sigma factor activity
I6J81_RS22085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6J81_RS22115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J81_RS22125	COG2161	toxin-antitoxin pair type II binding
I6J81_RS22135	COG0454	-acetyltransferase
I6J81_RS22140	COG1690	Belongs to the RtcB family
I6J81_RS22145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J81_RS22150	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J81_RS22170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J81_RS22190	COG0582	viral genome integration into host DNA
I6J81_RS22305	COG0582	viral genome integration into host DNA
I6J81_RS22335	COG3477	response to acidic pH
I6J81_RS22345	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6J81_RS22400	COG1902	pentaerythritol trinitrate reductase activity
I6J81_RS22405	COG1073	alpha beta
I6J81_RS22410	COG0583	DNA-binding transcription factor activity
I6J81_RS22420	COG0667	Aldo Keto reductase
I6J81_RS22425	COG0656	L-ascorbic acid biosynthetic process
I6J81_RS22430	COG1388	LysM domain
I6J81_RS22435	COG3708	Transcriptional regulator
I6J81_RS22435	COG2207	Transcriptional regulator
I6J81_RS22440	COG0656	L-ascorbic acid biosynthetic process
I6J81_RS22445	COG3059	membrane
I6J81_RS22455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J81_RS22460	COG2207	Transcriptional regulator
I6J81_RS22465	COG0247	lactate metabolic process
I6J81_RS22470	COG1139	Iron-sulfur cluster binding protein
I6J81_RS22475	COG1556	Lactate utilization protein
I6J81_RS22485	COG3468	outer membrane autotransporter barrel domain protein
I6J81_RS22500	COG2771	luxR family
I6J81_RS22500	COG2200	EAL domain
I6J81_RS22505	COG0582	viral genome integration into host DNA
I6J81_RS22525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J81_RS22530	COG2771	luxR family
I6J81_RS22530	COG2200	EAL domain
I6J81_RS22535	COG0583	DNA-binding transcription factor activity
I6J81_RS22545	COG0666	response to abiotic stimulus
I6J81_RS22555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J81_RS22560	COG1304	FMN binding
I6J81_RS22570	COG0549	Belongs to the carbamate kinase family
I6J81_RS22575	COG0402	S-adenosylhomocysteine deaminase activity
I6J81_RS22580	COG1064	alcohol dehydrogenase
I6J81_RS22590	COG1280	lysine exporter protein (LysE YggA)
I6J81_RS22600	COG3829	transcription factor binding
I6J81_RS22605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6J81_RS22610	COG0372	Belongs to the citrate synthase family
I6J81_RS22615	COG2079	MmgE PrpD family protein
I6J81_RS22620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J81_RS22625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J81_RS22630	COG0402	S-adenosylhomocysteine deaminase activity
I6J81_RS22635	COG0110	maltose O-acetyltransferase activity
I6J81_RS22640	COG2223	nitrite transmembrane transporter activity
I6J81_RS22650	COG1609	Transcriptional regulator
I6J81_RS22660	COG3122	Protein conserved in bacteria
I6J81_RS22690	COG1215	transferase activity, transferring glycosyl groups
I6J81_RS22695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J81_RS22700	COG4521	taurine ABC transporter
I6J81_RS22705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J81_RS22710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J81_RS22715	COG2175	clavaminate synthase activity
I6J81_RS22720	COG0113	porphobilinogen synthase activity
I6J81_RS22725	COG3468	outer membrane autotransporter barrel domain protein
I6J81_RS22730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J81_RS22735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J81_RS22740	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J81_RS22760	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J81_RS22775	COG1785	Belongs to the alkaline phosphatase family
I6J81_RS22785	COG3706	GGDEF domain
I6J81_RS22790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J81_RS22810	COG4126	flavin adenine dinucleotide binding
I6J81_RS22835	COG1940	carbohydrate kinase activity
I6J81_RS22840	COG2814	Major facilitator Superfamily
I6J81_RS22845	COG0419	ATPase involved in DNA repair
I6J81_RS22850	COG0420	3'-5' exonuclease activity
I6J81_RS22855	COG0745	RESPONSE REGULATOR receiver
I6J81_RS22860	COG5002	protein histidine kinase activity
I6J81_RS22865	COG1114	Component of the transport system for branched-chain amino acids
I6J81_RS22870	COG1113	amino acid transport
I6J81_RS22875	COG0366	Alpha amylase catalytic
I6J81_RS22895	COG1862	Preprotein translocase
I6J81_RS22900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J81_RS22905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J81_RS22910	COG1403	HNH endonuclease
I6J81_RS22915	COG3248	Nucleoside-binding outer membrane protein
I6J81_RS22920	COG4238	major outer membrane lipoprotein
I6J81_RS22930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J81_RS22930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J81_RS22945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J81_RS22950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J81_RS22955	COG0667	Aldo Keto reductase
I6J81_RS22965	COG0142	geranyltranstransferase activity
I6J81_RS22980	COG0693	protein deglycase activity
I6J81_RS22985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J81_RS22995	COG2814	Major facilitator Superfamily
I6J81_RS23005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J81_RS23010	COG1845	cytochrome c oxidase, subunit III
I6J81_RS23015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J81_RS23020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J81_RS23025	COG2223	nitrite transmembrane transporter activity
I6J81_RS23030	COG3056	Lipoprotein
I6J81_RS23035	COG0271	Belongs to the BolA IbaG family
I6J81_RS23055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J81_RS23060	COG0776	regulation of translation
I6J81_RS23065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J81_RS23070	COG1555	photosystem II stabilization
I6J81_RS23075	COG0824	Thioesterase
I6J81_RS23085	COG4533	DNA binding
I6J81_RS23095	COG1522	sequence-specific DNA binding
I6J81_RS23100	COG1132	(ABC) transporter
I6J81_RS23105	COG1132	(ABC) transporter
I6J81_RS23110	COG0347	Belongs to the P(II) protein family
I6J81_RS23115	COG0004	ammonium transporteR
I6J81_RS23120	COG1946	Acyl-CoA thioesterase
I6J81_RS23125	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6J81_RS23130	COG3695	enzyme binding
I6J81_RS23140	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6J81_RS23145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6J81_RS23155	COG0110	maltose O-acetyltransferase activity
I6J81_RS23170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J81_RS23175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS23180	COG1309	transcriptional regulator
I6J81_RS23185	COG1196	nuclear chromosome segregation
I6J81_RS23185	COG3264	Mechanosensitive ion channel
I6J81_RS23195	COG3923	Primosomal replication protein n
I6J81_RS23200	COG2832	Protein of unknown function (DUF454)
I6J81_RS23210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J81_RS23245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J81_RS23250	COG4651	solute:proton antiporter activity
I6J81_RS23250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J81_RS23255	COG2223	nitrite transmembrane transporter activity
I6J81_RS23260	COG0737	Belongs to the 5'-nucleotidase family
I6J81_RS23275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J81_RS23280	COG3735	TraB family
I6J81_RS23290	COG3093	addiction module antidote protein HigA
I6J81_RS23295	COG2217	Heavy metal translocating P-type atpase
I6J81_RS23305	COG0531	amino acid
I6J81_RS23310	COG0789	Transcriptional regulator
I6J81_RS23320	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J81_RS23325	COG0330	HflC and HflK could
I6J81_RS23330	COG4619	ABC transporter
I6J81_RS23335	COG0390	transport system, permease component
I6J81_RS23340	COG3118	belongs to the thioredoxin family
I6J81_RS23345	COG0300	oxidoreductase activity
I6J81_RS23350	COG2755	lipolytic protein G-D-S-L family
I6J81_RS23355	COG4181	ATPase activity
I6J81_RS23360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J81_RS23380	COG1414	Transcriptional regulator
I6J81_RS23385	COG3960	tartronate-semialdehyde synthase activity
I6J81_RS23390	COG3622	Belongs to the hyi family
I6J81_RS23395	COG2084	Dehydrogenase
I6J81_RS23400	COG1953	Uracil, thiamine, allantoin
I6J81_RS23410	COG2233	PERMEase
I6J81_RS23415	COG1929	Belongs to the glycerate kinase type-1 family
I6J81_RS23420	COG3257	ureidoglycine aminohydrolase activity
I6J81_RS23425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J81_RS23430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J81_RS23435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J81_RS23440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J81_RS23450	COG0549	Belongs to the carbamate kinase family
I6J81_RS23455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J81_RS23460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J81_RS23475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J81_RS23485	COG1988	membrane-bound metal-dependent
I6J81_RS23490	COG2501	S4 domain
I6J81_RS23520	COG0500	methyltransferase
I6J81_RS23525	COG4571	Outer membrane protease
I6J81_RS23535	COG4783	chaperone-mediated protein folding
I6J81_RS23540	COG1215	transferase activity, transferring glycosyl groups
I6J81_RS23545	COG5002	protein histidine kinase activity
I6J81_RS23550	COG0745	RESPONSE REGULATOR receiver
I6J81_RS23555	COG1538	Outer membrane efflux protein
I6J81_RS23560	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS23565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J81_RS23570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J81_RS23575	COG1113	amino acid transport
I6J81_RS23580	COG0668	transmembrane transport
I6J81_RS23585	COG0778	Nitroreductase
I6J81_RS23590	COG2315	Protein conserved in bacteria
I6J81_RS23610	COG2977	Belongs to the P-Pant transferase superfamily
I6J81_RS23615	COG4771	TonB-dependent receptor
I6J81_RS23625	COG2382	esterase
I6J81_RS23630	COG3251	PFAM MbtH domain protein
I6J81_RS23635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J81_RS23635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J81_RS23640	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J81_RS23645	COG1120	ATPase activity
I6J81_RS23650	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS23655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J81_RS23665	COG4592	Periplasmic binding protein
I6J81_RS23670	COG1169	isochorismate synthase
I6J81_RS23675	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J81_RS23680	COG1535	isochorismatase
I6J81_RS23680	COG3433	isochorismatase activity
I6J81_RS23685	COG1028	Short-chain dehydrogenase reductase Sdr
I6J81_RS23690	COG2050	protein possibly involved in aromatic compounds catabolism
I6J81_RS23695	COG1966	Carbon starvation protein
I6J81_RS23700	COG2879	small protein
I6J81_RS23705	COG0371	Dehydrogenase
I6J81_RS23710	COG0436	Aminotransferase
I6J81_RS23715	COG1475	DNA binding
I6J81_RS23720	COG3969	phosphoadenosine phosphosulfate
I6J81_RS23725	COG0583	DNA-binding transcription factor activity
I6J81_RS23730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J81_RS23735	COG0450	alkyl hydroperoxide reductase
I6J81_RS23740	COG3634	alkyl hydroperoxide reductase activity
I6J81_RS23745	COG0589	response to stress
I6J81_RS23750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J81_RS23755	COG3719	Belongs to the RNase T2 family
I6J81_RS23760	COG0471	metal ion transport
I6J81_RS23775	COG3051	citrate lyase alpha subunit
I6J81_RS23780	COG2301	Belongs to the HpcH HpaI aldolase family
I6J81_RS23790	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6J81_RS23795	COG3290	protein histidine kinase activity
I6J81_RS23800	COG4565	transcriptional regulatory protein
I6J81_RS23805	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J81_RS23825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J81_RS23830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J81_RS23855	COG1686	Belongs to the peptidase S11 family
I6J81_RS23860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J81_RS23865	COG0772	Belongs to the SEDS family
I6J81_RS23870	COG0768	penicillin binding
I6J81_RS23880	COG0799	negative regulation of ribosome biogenesis
I6J81_RS23885	COG0406	alpha-ribazole phosphatase activity
I6J81_RS23895	COG1466	dna polymerase III delta subunit
I6J81_RS23910	COG2888	peptidyl-tyrosine sulfation
I6J81_RS23920	COG1126	abc transporter atp-binding protein
I6J81_RS23925	COG0765	amino acid transport
I6J81_RS23930	COG0765	amino acid transport
I6J81_RS23935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J81_RS23945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6J81_RS23950	COG4535	Mg2 and Co2 transporter CorC
I6J81_RS23960	COG1702	phosphate starvation-inducible protein PhoH
I6J81_RS23970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J81_RS24010	COG0367	asparagine synthase
I6J81_RS24015	COG0647	UMP catabolic process
I6J81_RS24020	COG1846	Transcriptional regulator
I6J81_RS24020	COG1940	carbohydrate kinase activity
I6J81_RS24025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J81_RS24035	COG2190	(PTS) system
I6J81_RS24035	COG1263	PTS System
I6J81_RS24035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J81_RS24055	COG0861	Integral membrane protein TerC family
I6J81_RS24060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J81_RS24065	COG1454	alcohol dehydrogenase
I6J81_RS24070	COG3395	kinase activity
I6J81_RS24075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J81_RS24080	COG1349	DNA-binding transcription factor activity
I6J81_RS24100	COG0735	belongs to the Fur family
I6J81_RS24110	COG0716	FMN binding
I6J81_RS24120	COG0596	Alpha beta hydrolase
I6J81_RS24125	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6J81_RS24130	COG0033	Phosphoglucomutase
I6J81_RS24135	COG0531	amino acid
I6J81_RS24140	COG1982	Orn Lys Arg decarboxylase major
I6J81_RS24150	COG0745	RESPONSE REGULATOR receiver
I6J81_RS24155	COG2205	protein histidine kinase activity
I6J81_RS24185	COG3272	Protein of unknown function (DUF1722)
I6J81_RS24190	COG0415	Belongs to the DNA photolyase family
I6J81_RS24200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J81_RS24205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J81_RS24210	COG1984	allophanate hydrolase subunit 2
I6J81_RS24225	COG3180	Ammonia monooxygenase
I6J81_RS24230	COG3539	Fimbrial protein
I6J81_RS24235	COG0372	Belongs to the citrate synthase family
I6J81_RS24245	COG2009	succinate dehydrogenase
I6J81_RS24250	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J81_RS24255	COG1053	succinate dehydrogenase
I6J81_RS24260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J81_RS24265	COG0567	Dehydrogenase, E1 component
I6J81_RS24270	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J81_RS24280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J81_RS24290	COG1271	oxidase subunit
I6J81_RS24295	COG1294	oxidase, subunit
I6J81_RS24300	COG4890	Cyd operon protein YbgT
I6J81_RS24305	COG3790	cyd operon protein YbgE
I6J81_RS24310	COG0824	Thioesterase
I6J81_RS24315	COG0811	peptide transport
I6J81_RS24320	COG0848	biopolymer transport protein
I6J81_RS24325	COG3064	Membrane
I6J81_RS24335	COG2885	chlorophyll binding
I6J81_RS24340	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6J81_RS24380	COG3201	nicotinamide mononucleotide transporter
I6J81_RS24385	COG1230	cation diffusion facilitator family transporter
I6J81_RS24395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J81_RS24405	COG2017	converts alpha-aldose to the beta-anomer
I6J81_RS24415	COG1085	galactose-1-phosphate uridylyltransferase
I6J81_RS24420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J81_RS24425	COG1119	ATPase activity
I6J81_RS24430	COG2005	Transcriptional regulator
I6J81_RS24430	COG3585	molybdate ion transport
I6J81_RS24440	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J81_RS24445	COG4149	molybdate abc transporter
I6J81_RS24450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J81_RS24455	COG0561	phosphatase activity
I6J81_RS24465	COG0583	DNA-binding transcription factor activity
I6J81_RS24470	COG2828	Protein conserved in bacteria
I6J81_RS24475	COG0471	metal ion transport
I6J81_RS24480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J81_RS24485	COG4677	pectinesterase activity
I6J81_RS24490	COG0582	viral genome integration into host DNA
I6J81_RS24560	COG3723	Recombinational DNA repair protein, rece pathway
I6J81_RS24720	COG1783	phage Terminase large subunit
I6J81_RS24830	COG2948	multi-organism process
I6J81_RS24880	COG0250	Participates in transcription elongation, termination and antitermination
I6J81_RS24935	COG2026	Addiction module toxin, RelE StbE family
I6J81_RS24975	COG1192	Involved in chromosome partitioning
I6J81_RS25020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J81_RS25030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins