locus-tag	class	description
I6J88_RS00260	COG1475	DNA binding
I6J88_RS00435	COG4771	TonB-dependent receptor
I6J88_RS00445	COG3344	reverse transcriptase
I6J88_RS00470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6J88_RS00660	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6J88_RS00665	COG1196	nuclear chromosome segregation
I6J88_RS00695	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6J88_RS00710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J88_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J88_RS00720	COG1121	(ABC) transporter
I6J88_RS00735	COG0538	isocitrate dehydrogenase activity
I6J88_RS00745	COG5562	phage envelope protein
I6J88_RS00750	COG0789	Transcriptional regulator
I6J88_RS00755	COG2200	EAL domain
I6J88_RS00835	COG2894	cell division
I6J88_RS00860	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J88_RS00875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J88_RS00880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J88_RS00900	COG2719	SpoVR family
I6J88_RS00910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J88_RS00920	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J88_RS00930	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6J88_RS00945	COG0157	Belongs to the NadC ModD family
I6J88_RS00950	COG0500	methyltransferase
I6J88_RS00955	COG1120	ATPase activity
I6J88_RS00960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS00965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J88_RS00975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J88_RS00975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS00975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J88_RS00980	COG1461	Dihydroxyacetone kinase
I6J88_RS00985	COG2376	Dihydroxyacetone kinase
I6J88_RS00990	COG3284	Transcriptional regulator
I6J88_RS01000	COG0012	GTP binding
I6J88_RS01015	COG0659	secondary active sulfate transmembrane transporter activity
I6J88_RS01020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J88_RS01045	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J88_RS01050	COG3094	Invasion gene expression up-regulator, SirB
I6J88_RS01055	COG2912	Transglutaminase-like superfamily
I6J88_RS01070	COG0387	Pfam Sodium calcium exchanger
I6J88_RS01075	COG4572	Cation transport regulator
I6J88_RS01080	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6J88_RS01085	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6J88_RS01090	COG4932	domain protein
I6J88_RS01095	COG2197	response regulator
I6J88_RS01100	COG3850	Histidine kinase
I6J88_RS01105	COG2223	nitrite transmembrane transporter activity
I6J88_RS01110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J88_RS01115	COG1140	nitrate reductase beta subunit
I6J88_RS01120	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J88_RS01125	COG2181	nitrate reductase activity
I6J88_RS01150	COG0788	formyltetrahydrofolate deformylase activity
I6J88_RS01160	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J88_RS01165	COG0745	RESPONSE REGULATOR receiver
I6J88_RS01170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J88_RS01180	COG1435	thymidine kinase activity
I6J88_RS01190	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS01190	COG1454	alcohol dehydrogenase
I6J88_RS01195	COG2095	MarC family integral membrane protein
I6J88_RS01205	COG4166	transmembrane transport
I6J88_RS01210	COG0601	transmembrane transport
I6J88_RS01215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J88_RS01220	COG0444	Belongs to the ABC transporter superfamily
I6J88_RS01225	COG4608	Belongs to the ABC transporter superfamily
I6J88_RS01245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J88_RS01250	COG2350	Protein conserved in bacteria
I6J88_RS01260	COG1607	acyl-coa hydrolase
I6J88_RS01280	COG3047	cAMP biosynthetic process
I6J88_RS01285	COG3685	Protein conserved in bacteria
I6J88_RS01290	COG3685	Protein conserved in bacteria
I6J88_RS01305	COG0135	phosphoribosylanthranilate isomerase activity
I6J88_RS01305	COG0134	indole-3-glycerol-phosphate synthase activity
I6J88_RS01310	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J88_RS01310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J88_RS01315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J88_RS01325	COG0613	PHP domain protein
I6J88_RS01330	COG0009	L-threonylcarbamoyladenylate synthase
I6J88_RS01335	COG4907	membrane protein (DUF2207)
I6J88_RS01340	COG1187	pseudouridine synthase activity
I6J88_RS01345	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6J88_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS01355	COG0616	signal peptide processing
I6J88_RS01365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J88_RS01370	COG0583	DNA-binding transcription factor activity
I6J88_RS01390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J88_RS01400	COG0671	phosphoesterase, PA-phosphatase related
I6J88_RS01405	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6J88_RS01410	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6J88_RS01420	COG0023	Translation Initiation Factor
I6J88_RS01430	COG1349	DNA-binding transcription factor activity
I6J88_RS01440	COG5001	Diguanylate cyclase
I6J88_RS01455	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J88_RS01455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J88_RS01460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J88_RS01470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS01475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J88_RS01485	COG2814	Major facilitator Superfamily
I6J88_RS01490	COG4172	Belongs to the ABC transporter superfamily
I6J88_RS01495	COG4172	Belongs to the ABC transporter superfamily
I6J88_RS01500	COG4171	peptide transport system, permease
I6J88_RS01505	COG4168	peptide transport system, permease
I6J88_RS01510	COG4166	transmembrane transport
I6J88_RS01525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6J88_RS01530	COG1842	Phage shock protein A
I6J88_RS01540	COG1983	PspC domain protein
I6J88_RS01550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J88_RS01555	COG0366	Alpha amylase catalytic
I6J88_RS01560	COG1653	transport
I6J88_RS01565	COG1175	transmembrane transport
I6J88_RS01570	COG0395	ABC-type sugar transport system, permease component
I6J88_RS01575	COG1063	alcohol dehydrogenase
I6J88_RS01580	COG1082	Xylose isomerase domain protein TIM barrel
I6J88_RS01585	COG0673	inositol 2-dehydrogenase activity
I6J88_RS01590	COG1554	hydrolase, family 65, central catalytic
I6J88_RS01595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J88_RS01610	COG1609	Transcriptional regulator
I6J88_RS01615	COG3106	COG3106 Predicted ATPase
I6J88_RS01625	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6J88_RS01630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J88_RS01635	COG4948	Mandelate Racemase Muconate Lactonizing
I6J88_RS01640	COG2866	Carboxypeptidase
I6J88_RS01645	COG0702	epimerase
I6J88_RS01650	COG1073	alpha beta
I6J88_RS01655	COG0583	DNA-binding transcription factor activity
I6J88_RS01660	COG4166	transmembrane transport
I6J88_RS01665	COG0668	transmembrane transport
I6J88_RS01670	COG3182	Iron-regulated membrane protein
I6J88_RS01675	COG0589	response to stress
I6J88_RS01680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J88_RS01685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J88_RS01695	COG2207	Transcriptional regulator
I6J88_RS01710	COG2840	Smr protein MutS2
I6J88_RS01715	COG3706	GGDEF domain
I6J88_RS01725	COG0513	Belongs to the DEAD box helicase family
I6J88_RS01750	COG0589	response to stress
I6J88_RS01755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J88_RS01760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J88_RS01760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J88_RS01760	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J88_RS01760	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J88_RS01765	COG3042	response to heat
I6J88_RS01770	COG3187	Heat shock protein
I6J88_RS01775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J88_RS01780	COG2911	Protein conserved in bacteria
I6J88_RS01790	COG3784	Protein of unknown function (DUF1318)
I6J88_RS01800	COG0667	Aldo Keto reductase
I6J88_RS01810	COG4589	Belongs to the CDS family
I6J88_RS01815	COG2267	carboxylic ester hydrolase activity
I6J88_RS01820	COG2453	phosphatase
I6J88_RS01820	COG0671	phosphoesterase, PA-phosphatase related
I6J88_RS01830	COG1643	Atp-dependent helicase
I6J88_RS01835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J88_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS01845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J88_RS01850	COG3038	cytochrome b561
I6J88_RS01870	COG0583	DNA-binding transcription factor activity
I6J88_RS01875	COG5383	Protein conserved in bacteria
I6J88_RS01885	COG2841	Protein conserved in bacteria
I6J88_RS01890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J88_RS01895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J88_RS01900	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6J88_RS01905	COG0500	methyltransferase
I6J88_RS01915	COG3135	benzoate transporter
I6J88_RS01920	COG1396	sequence-specific DNA binding
I6J88_RS01925	COG0826	peptidase U32
I6J88_RS01940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J88_RS01945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J88_RS01950	COG3842	ATPase activity
I6J88_RS01955	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J88_RS01960	COG1177	transmembrane transport
I6J88_RS01985	COG3238	Protein conserved in bacteria
I6J88_RS01990	COG1247	-acetyltransferase
I6J88_RS02010	COG1113	amino acid transport
I6J88_RS02015	COG0625	glutathione transferase activity
I6J88_RS02020	COG0625	glutathione transferase activity
I6J88_RS02030	COG3501	Rhs element vgr protein
I6J88_RS02040	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J88_RS02045	COG0384	phenazine biosynthesis protein PhzF
I6J88_RS02050	COG2181	nitrate reductase activity
I6J88_RS02055	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J88_RS02060	COG1140	nitrate reductase beta subunit
I6J88_RS02065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J88_RS02070	COG2223	nitrite transmembrane transporter activity
I6J88_RS02075	COG0697	spore germination
I6J88_RS02085	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS02090	COG2864	formate dehydrogenase
I6J88_RS02095	COG3093	addiction module antidote protein HigA
I6J88_RS02105	COG1064	alcohol dehydrogenase
I6J88_RS02125	COG1764	response to oxidative stress
I6J88_RS02140	COG1649	PFAM Uncharacterised BCR, COG1649
I6J88_RS02145	COG0531	amino acid
I6J88_RS02150	COG0076	glutamate decarboxylase activity
I6J88_RS02165	COG0641	radical SAM
I6J88_RS02170	COG3119	arylsulfatase activity
I6J88_RS02175	COG2207	Transcriptional regulator
I6J88_RS02185	COG0243	molybdopterin cofactor binding
I6J88_RS02190	COG3539	Fimbrial protein
I6J88_RS02195	COG3539	Fimbrial protein
I6J88_RS02200	COG3539	Fimbrial protein
I6J88_RS02205	COG3188	usher protein
I6J88_RS02215	COG3539	Fimbrial protein
I6J88_RS02225	COG0702	epimerase
I6J88_RS02255	COG3550	peptidyl-serine autophosphorylation
I6J88_RS02260	COG1396	sequence-specific DNA binding
I6J88_RS02270	COG3781	membrane
I6J88_RS02290	COG2066	Belongs to the glutaminase family
I6J88_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS02300	COG0583	DNA-binding transcription factor activity
I6J88_RS02320	COG1846	Transcriptional regulator
I6J88_RS02325	COG4977	sequence-specific DNA binding
I6J88_RS02335	COG2723	6-phospho-beta-galactosidase activity
I6J88_RS02345	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J88_RS02350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J88_RS02360	COG2188	Transcriptional regulator
I6J88_RS02365	COG0697	spore germination
I6J88_RS02370	COG2814	Major facilitator Superfamily
I6J88_RS02380	COG3706	GGDEF domain
I6J88_RS02385	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J88_RS02390	COG0339	signal peptide processing
I6J88_RS02395	COG4221	oxidoreductase activity
I6J88_RS02400	COG1802	Transcriptional regulator
I6J88_RS02410	COG0246	Mannitol dehydrogenase
I6J88_RS02415	COG0477	Major facilitator Superfamily
I6J88_RS02420	COG1063	alcohol dehydrogenase
I6J88_RS02425	COG4948	Mandelate Racemase Muconate Lactonizing
I6J88_RS02440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J88_RS02455	COG0243	molybdopterin cofactor binding
I6J88_RS02460	COG0243	molybdopterin cofactor binding
I6J88_RS02465	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS02470	COG3302	dmso reductase anchor subunit
I6J88_RS02475	COG3381	protein complex oligomerization
I6J88_RS02485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J88_RS02490	COG1940	carbohydrate kinase activity
I6J88_RS02495	COG0583	DNA-binding transcription factor activity
I6J88_RS02500	COG2814	Major facilitator Superfamily
I6J88_RS02515	COG3591	Belongs to the peptidase S1B family
I6J88_RS02530	COG0628	permease
I6J88_RS02535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6J88_RS02540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J88_RS02550	COG0531	amino acid
I6J88_RS02560	COG3136	membrane protein required for alginate biosynthesis
I6J88_RS02565	COG0745	RESPONSE REGULATOR receiver
I6J88_RS02570	COG2205	protein histidine kinase activity
I6J88_RS02580	COG0114	fumarate hydratase activity
I6J88_RS02585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J88_RS02585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J88_RS02590	COG1482	cell wall glycoprotein biosynthetic process
I6J88_RS02595	COG5339	Protein conserved in bacteria
I6J88_RS02610	COG3250	beta-galactosidase activity
I6J88_RS02615	COG1309	transcriptional regulator
I6J88_RS02620	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS02625	COG1609	Transcriptional regulator
I6J88_RS02630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS02630	COG1263	PTS System
I6J88_RS02635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J88_RS02645	COG0673	inositol 2-dehydrogenase activity
I6J88_RS02685	COG4659	FMN binding
I6J88_RS02690	COG4660	Part of a membrane complex involved in electron transport
I6J88_RS02695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J88_RS02700	COG3104	oligopeptide transport
I6J88_RS02705	COG0625	glutathione transferase activity
I6J88_RS02725	COG3895	Periplasmic Protein
I6J88_RS02735	COG3133	Outer membrane lipoprotein
I6J88_RS02750	COG1566	PFAM secretion protein HlyD family protein
I6J88_RS02755	COG1289	transmembrane transporter activity
I6J88_RS02760	COG2032	superoxide dismutase activity
I6J88_RS02765	COG4989	oxidoreductase activity
I6J88_RS02770	COG3313	Fe-S protein
I6J88_RS02780	COG1902	pentaerythritol trinitrate reductase activity
I6J88_RS02785	COG0346	lactoylglutathione lyase activity
I6J88_RS02795	COG1201	RNA secondary structure unwinding
I6J88_RS02800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J88_RS02805	COG0791	NLP P60 protein
I6J88_RS02810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J88_RS02815	COG2814	Major facilitator Superfamily
I6J88_RS02830	COG0583	DNA-binding transcription factor activity
I6J88_RS02835	COG2814	Major facilitator Superfamily
I6J88_RS02840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J88_RS02845	COG0307	riboflavin synthase, alpha
I6J88_RS02855	COG3468	outer membrane autotransporter barrel domain protein
I6J88_RS02880	COG4529	Protein conserved in bacteria
I6J88_RS02890	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6J88_RS02895	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS02905	COG2414	aldehyde ferredoxin oxidoreductase
I6J88_RS02910	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS02920	COG0469	pyruvate kinase activity
I6J88_RS02925	COG4238	major outer membrane lipoprotein
I6J88_RS02930	COG1376	ErfK ybiS ycfS ynhG family protein
I6J88_RS02945	COG0719	Fe-S assembly protein
I6J88_RS02950	COG0396	ATPase activity
I6J88_RS02955	COG0719	Fe-S assembly protein
I6J88_RS02960	COG0316	Belongs to the HesB IscA family
I6J88_RS02970	COG2050	protein possibly involved in aromatic compounds catabolism
I6J88_RS02975	COG0277	FAD linked oxidase domain protein
I6J88_RS02975	COG0247	lactate metabolic process
I6J88_RS02980	COG0628	permease
I6J88_RS02995	COG0738	Major facilitator superfamily
I6J88_RS03000	COG2271	Major facilitator Superfamily
I6J88_RS03015	COG4670	ketone body catabolic process
I6J88_RS03020	COG1960	acyl-CoA dehydrogenase activity
I6J88_RS03025	COG1917	Cupin 2, conserved barrel domain protein
I6J88_RS03025	COG2207	Transcriptional regulator
I6J88_RS03030	COG2086	electron transfer activity
I6J88_RS03035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J88_RS03040	COG0644	oxidoreductase
I6J88_RS03045	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J88_RS03050	COG0318	PFAM AMP-dependent synthetase and ligase
I6J88_RS03055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J88_RS03055	COG0574	Belongs to the PEP-utilizing enzyme family
I6J88_RS03065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J88_RS03070	COG4256	Hemin uptake protein
I6J88_RS03080	COG2200	EAL domain
I6J88_RS03085	COG0791	NLP P60 protein
I6J88_RS03095	COG0386	Belongs to the glutathione peroxidase family
I6J88_RS03155	COG3137	Salt-induced outer membrane protein
I6J88_RS03160	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J88_RS03170	COG3001	Fructosamine kinase
I6J88_RS03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J88_RS03185	COG1988	membrane-bound metal-dependent
I6J88_RS03190	COG1823	symporter activity
I6J88_RS03200	COG0753	catalase activity
I6J88_RS03210	COG1486	melibiose metabolic process
I6J88_RS03215	COG2169	Transcriptional regulator
I6J88_RS03215	COG1917	Cupin 2, conserved barrel domain protein
I6J88_RS03220	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J88_RS03225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J88_RS03230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J88_RS03235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J88_RS03245	COG0322	excinuclease ABC activity
I6J88_RS03255	COG3678	ATP-independent chaperone mediated protein folding
I6J88_RS03285	COG0708	Exodeoxyribonuclease III
I6J88_RS03290	COG0398	Pfam SNARE associated Golgi protein
I6J88_RS03300	COG0398	Pfam SNARE associated Golgi protein
I6J88_RS03305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J88_RS03310	COG4134	Bacterial extracellular solute-binding protein
I6J88_RS03315	COG4135	transport system, permease component
I6J88_RS03320	COG4136	ATPase activity
I6J88_RS03325	COG2897	thiosulfate sulfurtransferase activity
I6J88_RS03330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J88_RS03345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J88_RS03350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J88_RS03360	COG0778	Nitroreductase
I6J88_RS03365	COG0616	signal peptide processing
I6J88_RS03370	COG0252	asparaginase activity
I6J88_RS03375	COG1335	isochorismatase
I6J88_RS03380	COG2814	Major facilitator Superfamily
I6J88_RS03385	COG1349	DNA-binding transcription factor activity
I6J88_RS03390	COG0667	Aldo Keto reductase
I6J88_RS03395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS03400	COG0191	fructose-bisphosphate aldolase activity
I6J88_RS03405	COG1063	alcohol dehydrogenase
I6J88_RS03410	COG2271	Major facilitator Superfamily
I6J88_RS03415	COG1063	alcohol dehydrogenase
I6J88_RS03420	COG3139	Protein of unknown function (DUF1315)
I6J88_RS03430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J88_RS03435	COG0676	glucose-6-phosphate 1-epimerase activity
I6J88_RS03440	COG0656	L-ascorbic acid biosynthetic process
I6J88_RS03445	COG3713	MltA-interacting MipA family protein
I6J88_RS03450	COG2766	serine protein kinase
I6J88_RS03460	COG2199	diguanylate cyclase activity
I6J88_RS03465	COG2199	diguanylate cyclase activity
I6J88_RS03470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J88_RS03485	COG2207	Transcriptional regulator
I6J88_RS03490	COG2807	transmembrane transport
I6J88_RS03495	COG3189	MarR family transcriptional regulator
I6J88_RS03500	COG3042	response to heat
I6J88_RS03505	COG2203	Gaf domain
I6J88_RS03505	COG2199	diguanylate cyclase activity
I6J88_RS03520	COG2261	transglycosylase associated protein
I6J88_RS03530	COG3615	Tellurite resistance protein tehB
I6J88_RS03540	COG0583	DNA-binding transcription factor activity
I6J88_RS03545	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6J88_RS03550	COG0318	PFAM AMP-dependent synthetase and ligase
I6J88_RS03555	COG3065	identical protein binding
I6J88_RS03560	COG1214	PFAM Peptidase M22, glycoprotease
I6J88_RS03565	COG1199	ATP-dependent helicase activity
I6J88_RS03570	COG0251	oxidation-reduction process
I6J88_RS03585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J88_RS03595	COG1760	l-serine dehydratase
I6J88_RS03600	COG2200	EAL domain
I6J88_RS03605	COG1253	flavin adenine dinucleotide binding
I6J88_RS03610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS03610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS03615	COG3715	PTS system
I6J88_RS03620	COG3716	PTS system mannose fructose sorbose family IID component
I6J88_RS03635	COG2226	methyltransferase
I6J88_RS03665	COG1414	Transcriptional regulator
I6J88_RS03670	COG2814	Major facilitator Superfamily
I6J88_RS03680	COG0793	Belongs to the peptidase S41A family
I6J88_RS03690	COG1956	GAF domain-containing protein
I6J88_RS03695	COG2995	paraquat-inducible protein a
I6J88_RS03700	COG3008	intermembrane lipid transfer
I6J88_RS03720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J88_RS03730	COG1276	copper resistance
I6J88_RS03735	COG2372	response to copper ion
I6J88_RS03745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J88_RS03750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J88_RS03755	COG1770	oligopeptidase
I6J88_RS03760	COG2979	Protein of unknown function (DUF533)
I6J88_RS03770	COG3141	response to X-ray
I6J88_RS03780	COG0800	Aldolase
I6J88_RS03785	COG0129	dihydroxy-acid dehydratase activity
I6J88_RS03790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J88_RS03795	COG1737	Transcriptional regulator
I6J88_RS03800	COG0469	pyruvate kinase activity
I6J88_RS03805	COG1560	Kdo2-lipid A biosynthetic process
I6J88_RS03810	COG0739	heme binding
I6J88_RS03815	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6J88_RS03825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J88_RS03855	COG0217	transcriptional regulatory protein
I6J88_RS03860	COG0494	nUDIX hydrolase
I6J88_RS03870	COG1335	isochorismatase
I6J88_RS03875	COG1801	Protein of unknown function DUF72
I6J88_RS03880	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6J88_RS03895	COG0243	molybdopterin cofactor binding
I6J88_RS03900	COG3005	denitrification pathway
I6J88_RS03910	COG3102	Protein conserved in bacteria
I6J88_RS03925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J88_RS03930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J88_RS03935	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6J88_RS03940	COG0745	RESPONSE REGULATOR receiver
I6J88_RS03950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J88_RS03960	COG0840	transmembrane signaling receptor activity
I6J88_RS03965	COG0835	chemotaxis
I6J88_RS03970	COG0643	Histidine kinase
I6J88_RS03970	COG2198	Histidine kinase
I6J88_RS03975	COG1360	Flagellar Motor Protein
I6J88_RS03980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6J88_RS03995	COG0589	response to stress
I6J88_RS04005	COG1877	trehalose-phosphatase activity
I6J88_RS04010	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS04020	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS04025	COG1528	Iron-storage protein
I6J88_RS04045	COG1528	Iron-storage protein
I6J88_RS04055	COG0814	amino acid
I6J88_RS04060	COG3012	SEC-C Motif Domain Protein
I6J88_RS04060	COG3318	Belongs to the UPF0149 family
I6J88_RS04090	COG2197	response regulator
I6J88_RS04105	COG2197	response regulator
I6J88_RS04110	COG1126	abc transporter atp-binding protein
I6J88_RS04115	COG0765	amino acid transport
I6J88_RS04125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS04135	COG1191	sigma factor activity
I6J88_RS04145	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6J88_RS04150	COG1516	flagellar protein fliS
I6J88_RS04160	COG0366	Alpha amylase catalytic
I6J88_RS04170	COG2391	methyltransferase activity
I6J88_RS04175	COG0425	Belongs to the sulfur carrier protein TusA family
I6J88_RS04180	COG2135	peptidase activity
I6J88_RS04195	COG2207	Transcriptional regulator
I6J88_RS04200	COG1881	PFAM PEBP family protein
I6J88_RS04205	COG2076	Multidrug Resistance protein
I6J88_RS04215	COG1766	The M ring may be actively involved in energy transduction
I6J88_RS04220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J88_RS04225	COG1317	bacterial-type flagellum organization
I6J88_RS04230	COG1157	protein secretion by the type III secretion system
I6J88_RS04235	COG2882	bacterial-type flagellum organization
I6J88_RS04240	COG3144	bacterial-type flagellum assembly
I6J88_RS04245	COG1580	Controls the rotational direction of flagella during chemotaxis
I6J88_RS04250	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J88_RS04255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J88_RS04260	COG3190	flagellar
I6J88_RS04265	COG1338	Plays a role in the flagellum-specific transport system
I6J88_RS04270	COG1987	bacterial-type flagellum assembly
I6J88_RS04275	COG1684	flagellar biosynthetic protein fliR
I6J88_RS04280	COG2197	response regulator
I6J88_RS04295	COG3769	mannosylglycerate metabolic process
I6J88_RS04300	COG3706	GGDEF domain
I6J88_RS04305	COG5475	Uncharacterized small protein (DUF2158)
I6J88_RS04310	COG2354	Protein conserved in bacteria
I6J88_RS04315	COG0697	spore germination
I6J88_RS04320	COG3727	T/G mismatch-specific endonuclease activity
I6J88_RS04325	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J88_RS04330	COG1418	mRNA catabolic process
I6J88_RS04340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J88_RS04350	COG2205	protein histidine kinase activity
I6J88_RS04355	COG0745	RESPONSE REGULATOR receiver
I6J88_RS04360	COG2351	hydroxyisourate hydrolase activity
I6J88_RS04365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J88_RS04370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6J88_RS04375	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6J88_RS04380	COG0582	viral genome integration into host DNA
I6J88_RS04410	COG4916	TIR domain
I6J88_RS04520	COG0582	viral genome integration into host DNA
I6J88_RS04530	COG2814	Major facilitator Superfamily
I6J88_RS04535	COG1132	(ABC) transporter
I6J88_RS04550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J88_RS04550	COG2226	methyltransferase
I6J88_RS04550	COG3433	isochorismatase activity
I6J88_RS04570	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J88_RS04575	COG4771	TonB-dependent receptor
I6J88_RS04580	COG4932	domain protein
I6J88_RS04580	COG2373	Large extracellular alpha-helical protein
I6J88_RS04580	COG1388	LysM domain
I6J88_RS04605	COG0477	Major facilitator Superfamily
I6J88_RS04610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J88_RS04615	COG0217	transcriptional regulatory protein
I6J88_RS04625	COG0583	DNA-binding transcription factor activity
I6J88_RS04630	COG0583	DNA-binding transcription factor activity
I6J88_RS04640	COG0534	Mate efflux family protein
I6J88_RS04660	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J88_RS04685	COG0154	amidase activity
I6J88_RS04715	COG1960	acyl-CoA dehydrogenase activity
I6J88_RS04720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J88_RS04725	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J88_RS04740	COG2197	response regulator
I6J88_RS04760	COG1376	ErfK ybiS ycfS ynhG family protein
I6J88_RS04775	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6J88_RS04780	COG4771	TonB-dependent receptor
I6J88_RS04785	COG1475	DNA binding
I6J88_RS04790	COG3969	phosphoadenosine phosphosulfate
I6J88_RS04795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J88_RS04800	COG1215	transferase activity, transferring glycosyl groups
I6J88_RS04820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS04835	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6J88_RS04870	COG3547	Transposase (IS116 IS110 IS902 family)
I6J88_RS04920	COG1120	ATPase activity
I6J88_RS04925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS04980	COG2003	Belongs to the UPF0758 family
I6J88_RS05025	COG1289	transmembrane transporter activity
I6J88_RS05035	COG1686	Belongs to the peptidase S11 family
I6J88_RS05040	COG2246	polysaccharide biosynthetic process
I6J88_RS05065	COG0582	viral genome integration into host DNA
I6J88_RS05070	COG2925	Exonuclease
I6J88_RS05075	COG0425	Belongs to the sulfur carrier protein TusA family
I6J88_RS05080	COG2391	methyltransferase activity
I6J88_RS05085	COG0531	amino acid
I6J88_RS05095	COG0583	DNA-binding transcription factor activity
I6J88_RS05100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J88_RS05105	COG4115	mRNA cleavage
I6J88_RS05110	COG2161	toxin-antitoxin pair type II binding
I6J88_RS05125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J88_RS05140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J88_RS05170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J88_RS05175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J88_RS05190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J88_RS05205	COG0438	transferase activity, transferring glycosyl groups
I6J88_RS05215	COG1216	Glycosyl transferase, family 2
I6J88_RS05230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J88_RS05240	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J88_RS05245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J88_RS05255	COG0438	transferase activity, transferring glycosyl groups
I6J88_RS05260	COG2327	Polysaccharide pyruvyl transferase
I6J88_RS05265	COG2244	polysaccharide biosynthetic process
I6J88_RS05270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J88_RS05275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J88_RS05280	COG0662	Cupin 2, conserved barrel domain protein
I6J88_RS05280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J88_RS05285	COG0297	glycogen (starch) synthase activity
I6J88_RS05290	COG1051	belongs to the nudix hydrolase family
I6J88_RS05295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J88_RS05300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J88_RS05305	COG0110	maltose O-acetyltransferase activity
I6J88_RS05310	COG1216	Glycosyl transferase, family 2
I6J88_RS05320	COG0438	transferase activity, transferring glycosyl groups
I6J88_RS05325	COG1045	serine acetyltransferase
I6J88_RS05330	COG0463	Glycosyl transferase, family 2
I6J88_RS05335	COG0489	protein tyrosine kinase activity
I6J88_RS05335	COG3206	protein involved in exopolysaccharide biosynthesis
I6J88_RS05340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J88_RS05345	COG1596	polysaccharide export
I6J88_RS05355	COG1253	flavin adenine dinucleotide binding
I6J88_RS05360	COG2982	Protein involved in outer membrane biogenesis
I6J88_RS05370	COG0572	uridine kinase
I6J88_RS05380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J88_RS05385	COG0443	Heat shock 70 kDa protein
I6J88_RS05390	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6J88_RS05395	COG0631	protein serine/threonine phosphatase activity
I6J88_RS05400	COG4245	von Willebrand factor, type A
I6J88_RS05435	COG2205	protein histidine kinase activity
I6J88_RS05440	COG0745	RESPONSE REGULATOR receiver
I6J88_RS05470	COG0826	peptidase U32
I6J88_RS05490	COG1063	alcohol dehydrogenase
I6J88_RS05495	COG3775	system Galactitol-specific IIC component
I6J88_RS05500	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J88_RS05505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS05520	COG1830	Aldolase
I6J88_RS05525	COG2211	Major facilitator Superfamily
I6J88_RS05530	COG1397	ADP-ribosylglycohydrolase
I6J88_RS05535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS05540	COG2188	Transcriptional regulator
I6J88_RS05545	COG3757	hydrolase, family 25
I6J88_RS05550	COG0351	phosphomethylpyrimidine kinase
I6J88_RS05570	COG5455	response to cobalt ion
I6J88_RS05575	COG3539	Fimbrial protein
I6J88_RS05580	COG3188	usher protein
I6J88_RS05585	COG3121	Chaperone
I6J88_RS05590	COG3539	Fimbrial protein
I6J88_RS05600	COG0489	protein tyrosine kinase activity
I6J88_RS05610	COG3831	ATPase activity
I6J88_RS05615	COG3831	ATPase activity
I6J88_RS05625	COG0714	Associated with various cellular activities
I6J88_RS05630	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6J88_RS05635	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J88_RS05645	COG4808	Protein conserved in bacteria
I6J88_RS05650	COG4807	Protein conserved in bacteria
I6J88_RS05655	COG3279	Response regulator of the LytR AlgR family
I6J88_RS05660	COG3275	phosphorelay sensor kinase activity
I6J88_RS05665	COG0789	Transcriptional regulator
I6J88_RS05675	COG1174	glycine betaine transport
I6J88_RS05680	COG1125	glycine betaine transport
I6J88_RS05685	COG1174	glycine betaine transport
I6J88_RS05690	COG1732	Glycine betaine
I6J88_RS05695	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J88_RS05700	COG0277	FAD linked oxidase domain protein
I6J88_RS05705	COG1686	Belongs to the peptidase S11 family
I6J88_RS05715	COG0586	Pfam SNARE associated Golgi protein
I6J88_RS05720	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS05725	COG1538	Outer membrane efflux protein
I6J88_RS05735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J88_RS05745	COG1346	cytolysis
I6J88_RS05755	COG2949	membrane
I6J88_RS05765	COG0493	'glutamate synthase
I6J88_RS05770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J88_RS05770	COG0167	dihydroorotate dehydrogenase activity
I6J88_RS05775	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS05785	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS05790	COG1609	Transcriptional regulator
I6J88_RS05795	COG2311	Membrane
I6J88_RS05810	COG4771	TonB-dependent receptor
I6J88_RS05815	COG0833	amino acid
I6J88_RS05820	COG0583	DNA-binding transcription factor activity
I6J88_RS05825	COG2855	membrane
I6J88_RS05835	COG1522	sequence-specific DNA binding
I6J88_RS05835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS05845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J88_RS05850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J88_RS05855	COG2313	pseudouridylate synthase activity
I6J88_RS05860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS05865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J88_RS05865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS05865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS05870	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J88_RS05875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS05875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS05880	COG2814	Major facilitator Superfamily
I6J88_RS05895	COG0246	Mannitol dehydrogenase
I6J88_RS05900	COG0523	cobalamin synthesis protein
I6J88_RS05905	COG0671	phosphoesterase, PA-phosphatase related
I6J88_RS05910	COG0791	NLP P60 protein
I6J88_RS05915	COG2200	EAL domain
I6J88_RS05920	COG4166	transmembrane transport
I6J88_RS05925	COG4174	ABC transporter (Permease)
I6J88_RS05930	COG4239	(ABC) transporter, permease
I6J88_RS05935	COG4172	Belongs to the ABC transporter superfamily
I6J88_RS05945	COG2814	Major facilitator Superfamily
I6J88_RS05950	COG1187	pseudouridine synthase activity
I6J88_RS05955	COG1061	Type III restriction enzyme res subunit
I6J88_RS05975	COG3083	sulfuric ester hydrolase activity
I6J88_RS05990	COG2197	response regulator
I6J88_RS05995	COG3088	subunit of a heme lyase
I6J88_RS05995	COG4235	cytochrome complex assembly
I6J88_RS06000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J88_RS06005	COG1138	Cytochrome C-type biogenesis protein
I6J88_RS06015	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J88_RS06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J88_RS06025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J88_RS06030	COG4133	protoheme IX ABC transporter activity
I6J88_RS06035	COG3005	denitrification pathway
I6J88_RS06040	COG3043	anaerobic respiration
I6J88_RS06045	COG0348	domain, Protein
I6J88_RS06050	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS06060	COG3062	negative regulation of establishment of protein localization
I6J88_RS06065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS06065	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS06075	COG0579	oxidoreductase
I6J88_RS06080	COG4615	Cyclic peptide transporter
I6J88_RS06085	COG3145	DNA-N1-methyladenine dioxygenase activity
I6J88_RS06090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J88_RS06090	COG2169	Transcriptional regulator
I6J88_RS06095	COG1477	protein flavinylation
I6J88_RS06100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J88_RS06105	COG0642	Histidine kinase
I6J88_RS06105	COG2198	Histidine kinase
I6J88_RS06110	COG2197	response regulator
I6J88_RS06115	COG2205	protein histidine kinase activity
I6J88_RS06115	COG0784	Response regulator, receiver
I6J88_RS06120	COG3852	Histidine kinase
I6J88_RS06125	COG2204	response regulator
I6J88_RS06130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J88_RS06135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J88_RS06140	COG2031	fatty acid transporter
I6J88_RS06145	COG0183	Belongs to the thiolase family
I6J88_RS06150	COG4676	Protein conserved in bacteria
I6J88_RS06155	COG5445	Predicted secreted protein (DUF2300)
I6J88_RS06160	COG2373	Large extracellular alpha-helical protein
I6J88_RS06165	COG3234	Protein of unknown function (DUF1175)
I6J88_RS06170	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6J88_RS06175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J88_RS06185	COG3468	outer membrane autotransporter barrel domain protein
I6J88_RS06190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J88_RS06195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J88_RS06200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J88_RS06205	COG3642	lipopolysaccharide core region biosynthetic process
I6J88_RS06210	COG0584	glycerophosphoryl diester phosphodiesterase
I6J88_RS06215	COG2271	Major facilitator Superfamily
I6J88_RS06220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J88_RS06230	COG0247	lactate metabolic process
I6J88_RS06235	COG5464	transposase or invertase
I6J88_RS06250	COG2271	Major facilitator Superfamily
I6J88_RS06255	COG4948	Mandelate Racemase Muconate Lactonizing
I6J88_RS06260	COG1414	Transcriptional regulator
I6J88_RS06305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J88_RS06325	COG0318	PFAM AMP-dependent synthetase and ligase
I6J88_RS06330	COG1441	menaquinone biosynthetic process
I6J88_RS06335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J88_RS06350	COG1169	isochorismate synthase
I6J88_RS06355	COG4575	ribosome binding
I6J88_RS06360	COG2153	protein acetylation
I6J88_RS06370	COG2304	oxidoreductase activity
I6J88_RS06375	COG2234	aminopeptidase activity
I6J88_RS06390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J88_RS06395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J88_RS06405	COG0839	Belongs to the complex I subunit 6 family
I6J88_RS06420	COG1034	ATP synthesis coupled electron transport
I6J88_RS06425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J88_RS06430	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6J88_RS06450	COG0583	DNA-binding transcription factor activity
I6J88_RS06455	COG0436	Aminotransferase
I6J88_RS06465	COG0490	domain, Protein
I6J88_RS06465	COG0471	metal ion transport
I6J88_RS06470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J88_RS06485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J88_RS06490	COG0280	phosphate acetyltransferase
I6J88_RS06490	COG0857	belongs to the CobB CobQ family
I6J88_RS06495	COG1288	antiporter activity
I6J88_RS06500	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J88_RS06505	COG0622	Phosphoesterase
I6J88_RS06510	COG0625	glutathione transferase activity
I6J88_RS06515	COG0625	glutathione transferase activity
I6J88_RS06520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J88_RS06525	COG1090	epimerase
I6J88_RS06530	COG5464	transposase or invertase
I6J88_RS06535	COG4598	ABC transporter
I6J88_RS06540	COG4160	amino acid transport
I6J88_RS06545	COG4215	(ABC) transporter
I6J88_RS06550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS06555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS06560	COG0163	prenyltransferase activity
I6J88_RS06565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J88_RS06570	COG1286	toxin biosynthetic process
I6J88_RS06575	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6J88_RS06580	COG0285	dihydrofolate synthase activity
I6J88_RS06590	COG0586	Pfam SNARE associated Golgi protein
I6J88_RS06600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J88_RS06615	COG2814	Major facilitator Superfamily
I6J88_RS06620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J88_RS06635	COG3101	peptidyl-lysine hydroxylation
I6J88_RS06640	COG0730	response to heat
I6J88_RS06670	COG3539	Fimbrial protein
I6J88_RS06675	COG3539	Fimbrial protein
I6J88_RS06680	COG3539	Fimbrial protein
I6J88_RS06685	COG3121	Chaperone
I6J88_RS06690	COG3188	usher protein
I6J88_RS06695	COG3539	Fimbrial protein
I6J88_RS06700	COG2062	phosphohistidine phosphatase, SixA
I6J88_RS06715	COG3691	Protein conserved in bacteria
I6J88_RS06720	COG2067	long-chain fatty acid transport protein
I6J88_RS06730	COG2116	formate transmembrane transporter activity
I6J88_RS06740	COG0583	DNA-binding transcription factor activity
I6J88_RS06745	COG2610	gluconate transmembrane transporter activity
I6J88_RS06750	COG3048	D-serine ammonia-lyase activity
I6J88_RS06755	COG0477	Major facilitator Superfamily
I6J88_RS06760	COG1566	PFAM secretion protein HlyD family protein
I6J88_RS06765	COG2197	response regulator
I6J88_RS06770	COG2205	protein histidine kinase activity
I6J88_RS06770	COG2198	Histidine kinase
I6J88_RS06770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS06770	COG0784	Response regulator, receiver
I6J88_RS06775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J88_RS06780	COG0679	Auxin Efflux Carrier
I6J88_RS06785	COG0028	Belongs to the TPP enzyme family
I6J88_RS06810	COG1560	Kdo2-lipid A biosynthetic process
I6J88_RS06820	COG0436	Aminotransferase
I6J88_RS06825	COG3275	phosphorelay sensor kinase activity
I6J88_RS06830	COG3279	Response regulator of the LytR AlgR family
I6J88_RS06835	COG2207	Transcriptional regulator
I6J88_RS06840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS06840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J88_RS06840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS06845	COG1363	Peptidase, m42
I6J88_RS06850	COG0006	proline dipeptidase activity
I6J88_RS06855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS06860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS06885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J88_RS06890	COG2200	EAL domain
I6J88_RS06890	COG2199	diguanylate cyclase activity
I6J88_RS06905	COG3415	Transposase
I6J88_RS06910	COG3415	Transposase
I6J88_RS06940	COG0583	DNA-binding transcription factor activity
I6J88_RS06950	COG2211	Major facilitator Superfamily
I6J88_RS06955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J88_RS06965	COG0583	DNA-binding transcription factor activity
I6J88_RS06970	COG0385	Bile acid
I6J88_RS06975	COG3530	Putative quorum-sensing-regulated virulence factor
I6J88_RS06995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J88_RS07000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS07005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J88_RS07010	COG2190	(PTS) system
I6J88_RS07025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J88_RS07030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J88_RS07035	COG4208	sulfate ABC transporter
I6J88_RS07040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J88_RS07045	COG4150	thiosulfate binding
I6J88_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS07065	COG2837	iron assimilation
I6J88_RS07085	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J88_RS07095	COG2207	Transcriptional regulator
I6J88_RS07100	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J88_RS07105	COG4816	utilization protein
I6J88_RS07115	COG4303	Ethanolamine ammonia lyase large subunit
I6J88_RS07120	COG4819	ethanolamine utilization protein
I6J88_RS07125	COG3192	ethanolamine utilization protein
I6J88_RS07130	COG1454	alcohol dehydrogenase
I6J88_RS07135	COG4820	ethanolamine utilization protein (EutJ)
I6J88_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS07145	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6J88_RS07150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J88_RS07155	COG0280	phosphate acetyltransferase
I6J88_RS07160	COG4812	Cobalamin adenosyltransferase
I6J88_RS07165	COG4766	ethanolamine catabolic process
I6J88_RS07170	COG4917	ethanolamine utilization protein
I6J88_RS07175	COG4810	utilization protein
I6J88_RS07180	COG0280	phosphate acetyltransferase
I6J88_RS07180	COG0281	malic enzyme
I6J88_RS07185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J88_RS07190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J88_RS07195	COG5342	invasion associated locus B
I6J88_RS07205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS07205	COG0493	'glutamate synthase
I6J88_RS07210	COG3850	Histidine kinase
I6J88_RS07215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J88_RS07225	COG1393	Belongs to the ArsC family
I6J88_RS07240	COG0400	carboxylic ester hydrolase activity
I6J88_RS07250	COG2321	neutral zinc metallopeptidase
I6J88_RS07260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6J88_RS07270	COG2716	regulation of RNA biosynthetic process
I6J88_RS07275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J88_RS07280	COG0628	permease
I6J88_RS07285	COG4783	chaperone-mediated protein folding
I6J88_RS07290	COG1393	Belongs to the ArsC family
I6J88_RS07300	COG2233	PERMEase
I6J88_RS07315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J88_RS07320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J88_RS07325	COG0248	Ppx GppA phosphatase
I6J88_RS07330	COG2200	EAL domain
I6J88_RS07345	COG3133	Outer membrane lipoprotein
I6J88_RS07375	COG0516	GMP reductase activity
I6J88_RS07375	COG0517	IMP dehydrogenase activity
I6J88_RS07400	COG1645	bacterial-type flagellum-dependent swarming motility
I6J88_RS07415	COG2976	Protein conserved in bacteria
I6J88_RS07445	COG4953	penicillin-binding protein 1C
I6J88_RS07450	COG2373	Large extracellular alpha-helical protein
I6J88_RS07455	COG2897	thiosulfate sulfurtransferase activity
I6J88_RS07475	COG2975	iron-sulfur cluster assembly
I6J88_RS07480	COG0633	Ferredoxin
I6J88_RS07500	COG0822	iron-sulfur transferase activity
I6J88_RS07520	COG0483	inositol monophosphate 1-phosphatase activity
I6J88_RS07525	COG1073	alpha beta
I6J88_RS07530	COG3711	transcriptional antiterminator
I6J88_RS07535	COG2814	Major facilitator Superfamily
I6J88_RS07540	COG2259	Doxx family
I6J88_RS07545	COG2017	converts alpha-aldose to the beta-anomer
I6J88_RS07550	COG1063	alcohol dehydrogenase
I6J88_RS07555	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS07560	COG1129	ABC transporter
I6J88_RS07565	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS07570	COG0457	Tetratricopeptide repeat
I6J88_RS07575	COG1940	carbohydrate kinase activity
I6J88_RS07585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J88_RS07585	COG1017	nitric oxide dioxygenase activity
I6J88_RS07590	COG0347	Belongs to the P(II) protein family
I6J88_RS07595	COG2204	response regulator
I6J88_RS07600	COG3170	Tfp pilus assembly protein FimV
I6J88_RS07605	COG2205	protein histidine kinase activity
I6J88_RS07610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J88_RS07610	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J88_RS07620	COG0590	tRNA wobble adenosine to inosine editing
I6J88_RS07625	COG0560	Phosphoserine phosphatase
I6J88_RS07630	COG1737	Transcriptional regulator
I6J88_RS07635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS07650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J88_RS07670	COG0681	Belongs to the peptidase S26 family
I6J88_RS07680	COG3086	response to oxidative stress
I6J88_RS07685	COG3026	antisigma factor binding
I6J88_RS07690	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6J88_RS07695	COG1595	DNA-templated transcription, initiation
I6J88_RS07705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J88_RS07715	COG0513	Belongs to the DEAD box helicase family
I6J88_RS07720	COG0583	DNA-binding transcription factor activity
I6J88_RS07740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J88_RS07745	COG3118	belongs to the thioredoxin family
I6J88_RS07750	COG3148	PFAM DTW domain containing protein
I6J88_RS07755	COG1042	CoA-binding domain protein
I6J88_RS07755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J88_RS07755	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J88_RS07760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J88_RS07765	COG5544	Lipoprotein
I6J88_RS07770	COG0477	Major facilitator Superfamily
I6J88_RS07805	COG0542	response to heat
I6J88_RS07815	COG0564	pseudouridine synthase activity
I6J88_RS07820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J88_RS07825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J88_RS07835	COG0077	Prephenate dehydratase
I6J88_RS07835	COG1605	Chorismate mutase
I6J88_RS07840	COG0287	Prephenate dehydrogenase
I6J88_RS07840	COG1605	Chorismate mutase
I6J88_RS07845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J88_RS07860	COG2199	diguanylate cyclase activity
I6J88_RS07865	COG2885	chlorophyll binding
I6J88_RS07890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J88_RS07895	COG4137	Cytochrome C assembly protein
I6J88_RS07900	COG4536	flavin adenine dinucleotide binding
I6J88_RS07915	COG0497	DNA recombination
I6J88_RS07920	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J88_RS07930	COG2867	negative regulation of translational initiation
I6J88_RS07950	COG0579	oxidoreductase
I6J88_RS07955	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS07960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J88_RS07965	COG1113	amino acid transport
I6J88_RS07970	COG1802	Transcriptional regulator
I6J88_RS07975	COG1652	LysM domain
I6J88_RS07980	COG0401	homolog of Blt101
I6J88_RS07985	COG0640	Transcriptional regulator
I6J88_RS07990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J88_RS07995	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6J88_RS08010	COG4575	ribosome binding
I6J88_RS08020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J88_RS08025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J88_RS08035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J88_RS08040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J88_RS08045	COG4175	Glycine betaine
I6J88_RS08050	COG4176	ABC-type proline glycine betaine transport system permease component
I6J88_RS08055	COG2113	Glycine betaine
I6J88_RS08060	COG2814	Major facilitator Superfamily
I6J88_RS08065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J88_RS08075	COG1846	Transcriptional regulator
I6J88_RS08080	COG1566	PFAM secretion protein HlyD family protein
I6J88_RS08085	COG2814	Major facilitator Superfamily
I6J88_RS08110	COG1238	metal cluster binding
I6J88_RS08115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J88_RS08145	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6J88_RS08165	COG1546	Belongs to the CinA family
I6J88_RS08170	COG2951	lytic endotransglycosylase activity
I6J88_RS08175	COG3730	PTS system glucitol sorbitol-specific
I6J88_RS08180	COG3732	PTS system glucitol sorbitol-specific
I6J88_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS08195	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS08200	COG1349	DNA-binding transcription factor activity
I6J88_RS08205	COG0517	IMP dehydrogenase activity
I6J88_RS08205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J88_RS08225	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J88_RS08230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS08240	COG5499	transcription regulator containing HTH domain
I6J88_RS08245	COG4680	protein conserved in bacteria
I6J88_RS08255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J88_RS08265	COG3260	NADH ubiquinone oxidoreductase 20
I6J88_RS08270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J88_RS08275	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6J88_RS08275	COG3261	NADH dehydrogenase
I6J88_RS08280	COG0650	Formate hydrogenlyase subunit 4
I6J88_RS08285	COG0651	ATP synthesis coupled electron transport
I6J88_RS08290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS08300	COG0375	protein maturation
I6J88_RS08305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J88_RS08310	COG0298	carbon dioxide binding
I6J88_RS08315	COG0409	Hydrogenase expression formation protein
I6J88_RS08320	COG0309	Hydrogenase expression formation protein (HypE)
I6J88_RS08325	COG3604	Transcriptional regulator
I6J88_RS08375	COG0582	viral genome integration into host DNA
I6J88_RS08385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J88_RS08390	COG1349	DNA-binding transcription factor activity
I6J88_RS08395	COG2084	Dehydrogenase
I6J88_RS08400	COG3395	kinase activity
I6J88_RS08405	COG0235	Class ii aldolase
I6J88_RS08410	COG3622	Belongs to the hyi family
I6J88_RS08415	COG2610	gluconate transmembrane transporter activity
I6J88_RS08430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J88_RS08435	COG1388	LysM domain
I6J88_RS08435	COG4942	peptidase
I6J88_RS08450	COG0585	pseudouridine synthase activity
I6J88_RS08490	COG2234	aminopeptidase activity
I6J88_RS08510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J88_RS08515	COG0720	synthase
I6J88_RS08520	COG0644	oxidoreductase
I6J88_RS08525	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J88_RS08530	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J88_RS08535	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J88_RS08540	COG2086	electron transfer activity
I6J88_RS08545	COG0477	Major facilitator Superfamily
I6J88_RS08550	COG0277	FAD linked oxidase domain protein
I6J88_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS08560	COG2223	nitrite transmembrane transporter activity
I6J88_RS08565	COG1070	Carbohydrate kinase
I6J88_RS08570	COG0602	queuosine metabolic process
I6J88_RS08580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J88_RS08590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J88_RS08605	COG3956	TIGRFAM MazG family protein
I6J88_RS08610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J88_RS08620	COG3850	Histidine kinase
I6J88_RS08620	COG4999	Histidine kinase
I6J88_RS08620	COG2205	protein histidine kinase activity
I6J88_RS08620	COG3437	response regulator, receiver
I6J88_RS08625	COG4948	Mandelate Racemase Muconate Lactonizing
I6J88_RS08630	COG4948	Mandelate Racemase Muconate Lactonizing
I6J88_RS08635	COG2271	Major facilitator Superfamily
I6J88_RS08640	COG0716	FMN binding
I6J88_RS08645	COG0564	pseudouridine synthase activity
I6J88_RS08650	COG3098	single-species biofilm formation
I6J88_RS08665	COG1611	Belongs to the LOG family
I6J88_RS08670	COG0814	amino acid
I6J88_RS08675	COG1760	l-serine dehydratase
I6J88_RS08685	COG1454	alcohol dehydrogenase
I6J88_RS08690	COG0235	Class ii aldolase
I6J88_RS08695	COG0738	Major facilitator superfamily
I6J88_RS08705	COG1070	Carbohydrate kinase
I6J88_RS08715	COG1349	DNA-binding transcription factor activity
I6J88_RS08725	COG2363	Small membrane protein
I6J88_RS08730	COG0583	DNA-binding transcription factor activity
I6J88_RS08740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J88_RS08745	COG2166	iron-sulfur cluster assembly
I6J88_RS08750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J88_RS08755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6J88_RS08795	COG2885	chlorophyll binding
I6J88_RS08875	COG1484	DNA-dependent DNA replication
I6J88_RS08880	COG4584	PFAM Integrase catalytic
I6J88_RS08935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J88_RS08940	COG1263	PTS System
I6J88_RS08940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS08945	COG3711	transcriptional antiterminator
I6J88_RS08950	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J88_RS08955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J88_RS08955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J88_RS08960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J88_RS08965	COG1074	ATP-dependent DNA helicase activity
I6J88_RS08970	COG1025	Belongs to the peptidase M16 family
I6J88_RS08975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J88_RS08980	COG4967	type IV pilus modification protein PilV
I6J88_RS08990	COG4795	General secretion pathway protein
I6J88_RS08995	COG2165	general secretion pathway protein
I6J88_RS09010	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6J88_RS09025	COG0861	Integral membrane protein TerC family
I6J88_RS09035	COG0667	Aldo Keto reductase
I6J88_RS09050	COG1609	Transcriptional regulator
I6J88_RS09060	COG0583	DNA-binding transcription factor activity
I6J88_RS09065	COG1794	racemase activity, acting on amino acids and derivatives
I6J88_RS09070	COG2814	Major facilitator Superfamily
I6J88_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS09085	COG0183	Belongs to the thiolase family
I6J88_RS09090	COG0814	amino acid
I6J88_RS09100	COG4942	peptidase
I6J88_RS09105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J88_RS09110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J88_RS09115	COG2080	2 iron, 2 sulfur cluster binding
I6J88_RS09120	COG3829	transcription factor binding
I6J88_RS09125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J88_RS09130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J88_RS09135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J88_RS09145	COG0549	Belongs to the carbamate kinase family
I6J88_RS09150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J88_RS09150	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J88_RS09155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J88_RS09160	COG2068	MobA-Related Protein
I6J88_RS09165	COG0493	'glutamate synthase
I6J88_RS09165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS09170	COG0402	S-adenosylhomocysteine deaminase activity
I6J88_RS09175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J88_RS09180	COG2080	2 iron, 2 sulfur cluster binding
I6J88_RS09180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J88_RS09185	COG2233	PERMEase
I6J88_RS09190	COG0402	S-adenosylhomocysteine deaminase activity
I6J88_RS09195	COG2252	PERMEase
I6J88_RS09200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS09205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS09205	COG0493	'glutamate synthase
I6J88_RS09210	COG2233	PERMEase
I6J88_RS09230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J88_RS09240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J88_RS09245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J88_RS09250	COG4974	Belongs to the 'phage' integrase family
I6J88_RS09255	COG0716	FMN binding
I6J88_RS09265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J88_RS09275	COG1272	protein, Hemolysin III
I6J88_RS09285	COG2723	6-phospho-beta-galactosidase activity
I6J88_RS09300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J88_RS09310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J88_RS09315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J88_RS09320	COG0006	proline dipeptidase activity
I6J88_RS09340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J88_RS09350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J88_RS09370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J88_RS09370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J88_RS09380	COG2968	Membrane
I6J88_RS09385	COG1279	arginine transmembrane transporter activity
I6J88_RS09390	COG0668	transmembrane transport
I6J88_RS09395	COG0191	fructose-bisphosphate aldolase activity
I6J88_RS09430	COG1122	ATPase activity
I6J88_RS09435	COG1072	(Pantothenic acid kinase))
I6J88_RS09445	COG1494	fructose-1,6-bisphosphatase
I6J88_RS09450	COG1063	alcohol dehydrogenase
I6J88_RS09455	COG2213	PTS system mannitol-specific
I6J88_RS09460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS09465	COG0330	HflC and HflK could
I6J88_RS09470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J88_RS09475	COG0501	Belongs to the peptidase M48B family
I6J88_RS09490	COG1166	arginine decarboxylase activity
I6J88_RS09510	COG2814	Major facilitator Superfamily
I6J88_RS09520	COG2356	endonuclease I
I6J88_RS09525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J88_RS09530	COG0189	ligase activity
I6J88_RS09545	COG2805	Type II/IV secretion system protein
I6J88_RS09550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J88_RS09555	COG0762	integral membrane protein
I6J88_RS09565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J88_RS09570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J88_RS09585	COG0252	asparaginase activity
I6J88_RS09600	COG3171	Protein conserved in bacteria
I6J88_RS09610	COG1194	a g-specific adenine glycosylase
I6J88_RS09625	COG2211	Major facilitator Superfamily
I6J88_RS09630	COG1982	Orn Lys Arg decarboxylase major
I6J88_RS09635	COG1811	Na channel or pump
I6J88_RS09645	COG0582	viral genome integration into host DNA
I6J88_RS09665	COG3436	PFAM IS66 Orf2 family protein
I6J88_RS09705	COG4983	Phage plasmid primase, P4 family domain protein
I6J88_RS09715	COG3468	outer membrane autotransporter barrel domain protein
I6J88_RS09730	COG2433	Pfam Transposase IS66
I6J88_RS09735	COG2020	methyltransferase activity
I6J88_RS09760	COG2003	Belongs to the UPF0758 family
I6J88_RS09810	COG4584	PFAM Integrase catalytic
I6J88_RS09815	COG1484	DNA-dependent DNA replication
I6J88_RS09895	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J88_RS09925	COG2165	general secretion pathway protein
I6J88_RS09930	COG1459	type II secretion system
I6J88_RS09935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J88_RS09955	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J88_RS09960	COG3064	Membrane
I6J88_RS09965	COG1620	l-lactate permease
I6J88_RS09975	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J88_RS09980	COG0247	lactate metabolic process
I6J88_RS09985	COG0277	FAD linked oxidase domain protein
I6J88_RS09990	COG0277	FAD linked oxidase domain protein
I6J88_RS09995	COG2186	Transcriptional regulator
I6J88_RS10000	COG0456	acetyltransferase
I6J88_RS10005	COG0318	PFAM AMP-dependent synthetase and ligase
I6J88_RS10015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J88_RS10020	COG0156	8-amino-7-oxononanoate synthase activity
I6J88_RS10030	COG0795	lipopolysaccharide-transporting ATPase activity
I6J88_RS10035	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6J88_RS10045	COG2244	polysaccharide biosynthetic process
I6J88_RS10050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J88_RS10055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J88_RS10060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J88_RS10065	COG0306	phosphate transporter
I6J88_RS10070	COG0754	glutathionylspermidine amidase activity
I6J88_RS10075	COG0625	glutathione transferase activity
I6J88_RS10080	COG0298	carbon dioxide binding
I6J88_RS10085	COG0375	protein maturation
I6J88_RS10090	COG1773	rubredoxin
I6J88_RS10095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J88_RS10100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J88_RS10105	COG5557	Pfam Polysulphide reductase, NrfD
I6J88_RS10110	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS10115	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6J88_RS10130	COG0667	Aldo Keto reductase
I6J88_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS10145	COG0848	biopolymer transport protein
I6J88_RS10150	COG0811	peptide transport
I6J88_RS10155	COG0626	cystathionine gamma-synthase activity
I6J88_RS10160	COG0586	Pfam SNARE associated Golgi protein
I6J88_RS10165	COG2207	Transcriptional regulator
I6J88_RS10170	COG1979	alcohol dehydrogenase
I6J88_RS10175	COG0656	L-ascorbic acid biosynthetic process
I6J88_RS10185	COG4238	major outer membrane lipoprotein
I6J88_RS10195	COG2186	Transcriptional regulator
I6J88_RS10200	COG0246	Mannitol dehydrogenase
I6J88_RS10205	COG1063	alcohol dehydrogenase
I6J88_RS10210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J88_RS10230	COG2132	Multicopper oxidase
I6J88_RS10235	COG0204	Acyl-transferase
I6J88_RS10240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J88_RS10245	COG4166	transmembrane transport
I6J88_RS10250	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J88_RS10255	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J88_RS10260	COG0745	RESPONSE REGULATOR receiver
I6J88_RS10265	COG0642	Histidine kinase
I6J88_RS10280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J88_RS10285	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J88_RS10290	COG1737	Transcriptional regulator
I6J88_RS10300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS10305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS10310	COG1120	ATPase activity
I6J88_RS10315	COG4774	siderophore transport
I6J88_RS10320	COG0187	DNA topoisomerase II activity
I6J88_RS10325	COG3150	esterase
I6J88_RS10330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J88_RS10335	COG3151	Protein conserved in bacteria
I6J88_RS10340	COG0494	nUDIX hydrolase
I6J88_RS10345	COG1538	Outer membrane efflux protein
I6J88_RS10355	COG0754	glutathionylspermidine amidase activity
I6J88_RS10365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J88_RS10375	COG3384	dioxygenase
I6J88_RS10390	COG3539	Fimbrial protein
I6J88_RS10395	COG3188	usher protein
I6J88_RS10400	COG3121	Chaperone
I6J88_RS10405	COG3539	Fimbrial protein
I6J88_RS10425	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J88_RS10430	COG2268	Band 7 protein
I6J88_RS10445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J88_RS10450	COG3025	triphosphatase activity
I6J88_RS10460	COG0675	Transposase, IS605 OrfB family
I6J88_RS10465	COG4991	sh3 domain protein
I6J88_RS10470	COG0617	tRNA 3'-terminal CCA addition
I6J88_RS10480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J88_RS10500	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J88_RS10505	COG0471	metal ion transport
I6J88_RS10515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J88_RS10520	COG0358	DNA primase activity
I6J88_RS10525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J88_RS10545	COG4220	transposase activity
I6J88_RS10610	COG2375	cellular response to nickel ion
I6J88_RS10615	COG1695	Transcriptional regulator
I6J88_RS10620	COG0840	transmembrane signaling receptor activity
I6J88_RS10630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J88_RS10635	COG1609	Transcriptional regulator
I6J88_RS10640	COG3250	beta-galactosidase activity
I6J88_RS10645	COG2731	YhcH YjgK YiaL family protein
I6J88_RS10650	COG0531	amino acid
I6J88_RS10660	COG3408	Glycogen debranching enzyme
I6J88_RS10660	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6J88_RS10665	COG1902	pentaerythritol trinitrate reductase activity
I6J88_RS10665	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J88_RS10670	COG5499	transcription regulator containing HTH domain
I6J88_RS10685	COG1451	nucleotide metabolic process
I6J88_RS10690	COG2949	membrane
I6J88_RS10695	COG0673	inositol 2-dehydrogenase activity
I6J88_RS10700	COG0861	Integral membrane protein TerC family
I6J88_RS10715	COG2721	sulfolactate sulfo-lyase activity
I6J88_RS10725	COG2271	Major facilitator Superfamily
I6J88_RS10730	COG2186	Transcriptional regulator
I6J88_RS10735	COG0586	Pfam SNARE associated Golgi protein
I6J88_RS10745	COG1422	Protein of unknown function (DUF1090)
I6J88_RS10750	COG4575	ribosome binding
I6J88_RS10755	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6J88_RS10765	COG2259	Doxx family
I6J88_RS10770	COG0435	Glutathione S-transferase
I6J88_RS10775	COG3152	Membrane
I6J88_RS10780	COG0583	DNA-binding transcription factor activity
I6J88_RS10785	COG1741	Belongs to the pirin family
I6J88_RS10800	COG0814	amino acid
I6J88_RS10805	COG1760	l-serine dehydratase
I6J88_RS10810	COG0251	oxidation-reduction process
I6J88_RS10815	COG1882	Formate acetyltransferase
I6J88_RS10820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J88_RS10830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J88_RS10835	COG0583	DNA-binding transcription factor activity
I6J88_RS10850	COG1929	Belongs to the glycerate kinase type-1 family
I6J88_RS10855	COG2084	Dehydrogenase
I6J88_RS10865	COG2271	Major facilitator Superfamily
I6J88_RS10870	COG2721	sulfolactate sulfo-lyase activity
I6J88_RS10875	COG1349	DNA-binding transcription factor activity
I6J88_RS10885	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS10895	COG3716	PTS system mannose fructose sorbose family IID component
I6J88_RS10900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS10905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J88_RS10910	COG2222	sugar isomerase
I6J88_RS10920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS10925	COG3715	PTS system
I6J88_RS10930	COG3716	PTS system mannose fructose sorbose family IID component
I6J88_RS10935	COG0363	glucosamine-6-phosphate deaminase activity
I6J88_RS10940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J88_RS10960	COG2823	Periplasmic or secreted lipoprotein
I6J88_RS10965	COG0701	Predicted permease
I6J88_RS10970	COG0702	epimerase
I6J88_RS10975	COG0693	protein deglycase activity
I6J88_RS10990	COG3153	acetyltransferase
I6J88_RS10995	COG3154	lipid carrier protein
I6J88_RS11000	COG0826	peptidase U32
I6J88_RS11005	COG0826	peptidase U32
I6J88_RS11010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J88_RS11015	COG0814	amino acid
I6J88_RS11020	COG0513	Belongs to the DEAD box helicase family
I6J88_RS11060	COG0195	Participates in both transcription termination and antitermination
I6J88_RS11080	COG2194	sulfuric ester hydrolase activity
I6J88_RS11090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J88_RS11100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J88_RS11105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J88_RS11115	COG1534	Rna-binding protein
I6J88_RS11120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J88_RS11125	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J88_RS11135	COG0697	spore germination
I6J88_RS11150	COG0142	geranyltranstransferase activity
I6J88_RS11155	COG3423	Transcriptional regulator
I6J88_RS11165	COG5007	Belongs to the BolA IbaG family
I6J88_RS11170	COG3113	response to antibiotic
I6J88_RS11175	COG2854	intermembrane phospholipid transfer
I6J88_RS11180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J88_RS11185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J88_RS11190	COG1127	ABC transporter
I6J88_RS11195	COG0530	calcium, potassium:sodium antiporter activity
I6J88_RS11200	COG0517	IMP dehydrogenase activity
I6J88_RS11200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J88_RS11205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J88_RS11210	COG3117	lipopolysaccharide transmembrane transporter activity
I6J88_RS11215	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J88_RS11220	COG1137	ATPase activity
I6J88_RS11225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6J88_RS11230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J88_RS11245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS11250	COG0515	serine threonine protein kinase
I6J88_RS11260	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J88_RS11265	COG5002	protein histidine kinase activity
I6J88_RS11265	COG0784	Response regulator, receiver
I6J88_RS11265	COG2198	Histidine kinase
I6J88_RS11270	COG1242	4 iron, 4 sulfur cluster binding
I6J88_RS11275	COG0067	glutamate synthase
I6J88_RS11275	COG0069	glutamate synthase activity
I6J88_RS11275	COG0070	glutamate synthase
I6J88_RS11280	COG0493	'glutamate synthase
I6J88_RS11285	COG4804	nuclease activity
I6J88_RS11290	COG2731	YhcH YjgK YiaL family protein
I6J88_RS11305	COG2814	Major facilitator Superfamily
I6J88_RS11320	COG2969	positive regulation of protein catabolic process
I6J88_RS11325	COG0625	glutathione transferase activity
I6J88_RS11340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J88_RS11345	COG3105	Protein conserved in bacteria
I6J88_RS11350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J88_RS11355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J88_RS11375	COG2732	(Barnase) inhibitor
I6J88_RS11395	COG0583	DNA-binding transcription factor activity
I6J88_RS11400	COG0312	modulator of DNA gyrase
I6J88_RS11405	COG3164	Protein of unknown function
I6J88_RS11410	COG1530	ribonuclease E activity
I6J88_RS11420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J88_RS11425	COG1792	Involved in formation and maintenance of cell shape
I6J88_RS11430	COG1077	Cell shape determining protein MreB Mrl
I6J88_RS11435	COG2200	EAL domain
I6J88_RS11435	COG2199	diguanylate cyclase activity
I6J88_RS11440	COG0604	alcohol dehydrogenase
I6J88_RS11445	COG0511	ligase activity, forming carbon-carbon bonds
I6J88_RS11450	COG0439	Biotin carboxylase
I6J88_RS11460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS11465	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS11470	COG1129	ABC transporter
I6J88_RS11475	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS11485	COG1349	DNA-binding transcription factor activity
I6J88_RS11490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS11495	COG3924	membrane
I6J88_RS11500	COG4145	pantothenate transmembrane transporter activity
I6J88_RS11510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J88_RS11520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6J88_RS11530	COG1309	transcriptional regulator
I6J88_RS11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS11540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J88_RS11550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS11555	COG4597	amino acid ABC transporter
I6J88_RS11560	COG0765	amino acid transport
I6J88_RS11565	COG1126	abc transporter atp-binding protein
I6J88_RS11605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J88_RS11620	COG0009	L-threonylcarbamoyladenylate synthase
I6J88_RS11625	COG0551	DNA topoisomerase type I activity
I6J88_RS11635	COG0758	DNA mediated transformation
I6J88_RS11645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J88_RS11650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J88_RS11650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J88_RS11655	COG0569	domain protein
I6J88_RS11665	COG3036	rescue of stalled ribosome
I6J88_RS11670	COG0789	Transcriptional regulator
I6J88_RS11710	COG0201	protein transport
I6J88_RS11800	COG0089	rRNA binding
I6J88_RS11825	COG3267	Type II secretory pathway component ExeA
I6J88_RS11825	COG3409	Peptidoglycan-binding domain 1 protein
I6J88_RS11830	COG3031	protein transport across the cell outer membrane
I6J88_RS11835	COG1450	Type ii and iii secretion system protein
I6J88_RS11840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J88_RS11845	COG1459	type II secretion system
I6J88_RS11850	COG2165	general secretion pathway protein
I6J88_RS11855	COG2165	general secretion pathway protein
I6J88_RS11860	COG2165	general secretion pathway protein
I6J88_RS11865	COG4795	General secretion pathway protein
I6J88_RS11870	COG3156	type II secretion system protein K
I6J88_RS11875	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J88_RS11880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J88_RS11885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J88_RS11890	COG2193	ferroxidase activity
I6J88_RS11895	COG2906	2 iron, 2 sulfur cluster binding
I6J88_RS11900	COG3979	chitinase
I6J88_RS11940	COG2964	Protein conserved in bacteria
I6J88_RS11945	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J88_RS11955	COG1047	Peptidyl-prolyl cis-trans
I6J88_RS11960	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J88_RS11975	COG0488	(ABC) transporter
I6J88_RS11980	COG0429	hydrolase of the alpha beta-hydrolase fold
I6J88_RS11990	COG3954	Phosphoribulokinase
I6J88_RS11995	COG1765	OsmC-like protein
I6J88_RS12000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J88_RS12005	COG1289	transmembrane transporter activity
I6J88_RS12010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J88_RS12015	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J88_RS12020	COG2184	nucleotidyltransferase activity
I6J88_RS12030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J88_RS12040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J88_RS12045	COG2146	nitrite reductase [NAD(P)H] activity
I6J88_RS12050	COG2116	formate transmembrane transporter activity
I6J88_RS12065	COG0626	cystathionine gamma-synthase activity
I6J88_RS12080	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6J88_RS12085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6J88_RS12090	COG3457	Alanine racemase
I6J88_RS12100	COG2188	Transcriptional regulator
I6J88_RS12105	COG0180	Tryptophanyl-tRNA synthetase
I6J88_RS12115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J88_RS12120	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6J88_RS12125	COG3266	domain, Protein
I6J88_RS12140	COG4796	Type ii and iii secretion system protein
I6J88_RS12155	COG3166	PFAM Fimbrial assembly family protein
I6J88_RS12160	COG4972	Pilus assembly protein
I6J88_RS12165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J88_RS12170	COG0494	nUDIX hydrolase
I6J88_RS12180	COG1011	Hydrolase
I6J88_RS12185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J88_RS12195	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J88_RS12215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J88_RS12220	COG2183	response to ionizing radiation
I6J88_RS12225	COG1918	ferrous iron import across plasma membrane
I6J88_RS12230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J88_RS12245	COG0596	Alpha beta hydrolase
I6J88_RS12260	COG2610	gluconate transmembrane transporter activity
I6J88_RS12265	COG1640	4-alpha-glucanotransferase
I6J88_RS12270	COG0058	SHG alpha-glucan phosphorylase activity
I6J88_RS12285	COG1690	Belongs to the RtcB family
I6J88_RS12290	COG4650	regulator
I6J88_RS12295	COG1349	DNA-binding transcription factor activity
I6J88_RS12310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J88_RS12350	COG3188	usher protein
I6J88_RS12355	COG3121	Chaperone
I6J88_RS12365	COG0058	SHG alpha-glucan phosphorylase activity
I6J88_RS12390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J88_RS12395	COG2095	MarC family integral membrane protein
I6J88_RS12400	COG2610	gluconate transmembrane transporter activity
I6J88_RS12405	COG3265	gluconokinase activity
I6J88_RS12410	COG1609	Transcriptional regulator
I6J88_RS12415	COG1741	Belongs to the pirin family
I6J88_RS12420	COG0673	inositol 2-dehydrogenase activity
I6J88_RS12425	COG1247	-acetyltransferase
I6J88_RS12430	COG3157	Type VI secretion system effector, Hcp
I6J88_RS12450	COG0405	Gamma-glutamyltransferase
I6J88_RS12460	COG0584	glycerophosphoryl diester phosphodiesterase
I6J88_RS12485	COG0410	ABC transporter
I6J88_RS12490	COG0411	ABC transporter
I6J88_RS12495	COG4177	L-phenylalanine transmembrane transporter activity
I6J88_RS12500	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS12505	COG0683	leucine binding
I6J88_RS12510	COG0456	acetyltransferase
I6J88_RS12515	COG0683	leucine binding
I6J88_RS12540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J88_RS12545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J88_RS12550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J88_RS12555	COG2177	Part of the ABC transporter FtsEX involved in
I6J88_RS12560	COG2884	Cell division ATP-binding protein ftsE
I6J88_RS12565	COG0552	protein localization to endoplasmic reticulum
I6J88_RS12570	COG0742	ribosomal rna small subunit methyltransferase
I6J88_RS12575	COG3776	membrane
I6J88_RS12585	COG3714	YhhN family
I6J88_RS12600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6J88_RS12610	COG0477	Major facilitator Superfamily
I6J88_RS12615	COG0628	permease
I6J88_RS12620	COG2091	lysine biosynthetic process via aminoadipic acid
I6J88_RS12625	COG0747	negative chemotaxis
I6J88_RS12630	COG0601	transmembrane transport
I6J88_RS12635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J88_RS12640	COG0444	Belongs to the ABC transporter superfamily
I6J88_RS12655	COG2188	Transcriptional regulator
I6J88_RS12665	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J88_RS12670	COG3775	system Galactitol-specific IIC component
I6J88_RS12685	COG0191	fructose-bisphosphate aldolase activity
I6J88_RS12690	COG0842	Transport permease protein
I6J88_RS12695	COG0842	Transport permease protein
I6J88_RS12695	COG1129	ABC transporter
I6J88_RS12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS12710	COG2081	HI0933 family
I6J88_RS12715	COG0306	phosphate transporter
I6J88_RS12725	COG0589	response to stress
I6J88_RS12730	COG3104	oligopeptide transport
I6J88_RS12740	COG0339	signal peptide processing
I6J88_RS12745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J88_RS12750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J88_RS12760	COG1393	Belongs to the ArsC family
I6J88_RS12770	COG3065	identical protein binding
I6J88_RS12775	COG2197	response regulator
I6J88_RS12780	COG3720	iron ion transport
I6J88_RS12785	COG4771	TonB-dependent receptor
I6J88_RS12800	COG3721	Heme iron utilization protein
I6J88_RS12810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS12820	COG1285	pathogenesis
I6J88_RS12835	COG3247	response to pH
I6J88_RS12840	COG2771	luxR family
I6J88_RS12850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS12855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J88_RS12860	COG2207	Transcriptional regulator
I6J88_RS12870	COG0076	glutamate decarboxylase activity
I6J88_RS12875	COG1858	cytochrome C peroxidase
I6J88_RS12885	COG2197	response regulator
I6J88_RS12890	COG0583	DNA-binding transcription factor activity
I6J88_RS12895	COG1295	ribonuclease BN
I6J88_RS12900	COG0477	Major facilitator Superfamily
I6J88_RS12905	COG2982	Protein involved in outer membrane biogenesis
I6J88_RS12910	COG2200	EAL domain
I6J88_RS12915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS12920	COG0612	Peptidase, M16
I6J88_RS12930	COG2199	diguanylate cyclase activity
I6J88_RS12930	COG2200	EAL domain
I6J88_RS12935	COG0457	Tetratricopeptide repeat
I6J88_RS12935	COG3118	belongs to the thioredoxin family
I6J88_RS12940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6J88_RS12945	COG1215	transferase activity, transferring glycosyl groups
I6J88_RS12950	COG1215	transferase activity, transferring glycosyl groups
I6J88_RS12975	COG2194	sulfuric ester hydrolase activity
I6J88_RS12990	COG0814	amino acid
I6J88_RS12995	COG4608	Belongs to the ABC transporter superfamily
I6J88_RS13000	COG0444	Belongs to the ABC transporter superfamily
I6J88_RS13005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J88_RS13010	COG0601	transmembrane transport
I6J88_RS13015	COG0747	negative chemotaxis
I6J88_RS13025	COG2194	sulfuric ester hydrolase activity
I6J88_RS13030	COG2223	nitrite transmembrane transporter activity
I6J88_RS13035	COG5571	outer membrane autotransporter
I6J88_RS13040	COG2818	Glycosylase
I6J88_RS13045	COG0456	acetyltransferase
I6J88_RS13050	COG0243	molybdopterin cofactor binding
I6J88_RS13055	COG2885	chlorophyll binding
I6J88_RS13070	COG2944	sequence-specific DNA binding
I6J88_RS13075	COG1278	Cold shock
I6J88_RS13105	COG3274	enterobacterial common antigen metabolic process
I6J88_RS13110	COG4682	membrane
I6J88_RS13115	COG4682	membrane
I6J88_RS13120	COG1070	Carbohydrate kinase
I6J88_RS13130	COG4213	ABC transporter substrate-binding protein
I6J88_RS13140	COG4214	carbohydrate transport
I6J88_RS13145	COG1609	Transcriptional regulator
I6J88_RS13145	COG2207	Transcriptional regulator
I6J88_RS13150	COG2992	FlgJ-related protein
I6J88_RS13155	COG0366	Alpha amylase catalytic
I6J88_RS13160	COG3977	Valine--pyruvate aminotransferase
I6J88_RS13165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J88_RS13170	COG1414	Transcriptional regulator
I6J88_RS13180	COG2731	YhcH YjgK YiaL family protein
I6J88_RS13190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6J88_RS13195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6J88_RS13200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6J88_RS13205	COG1070	Carbohydrate kinase
I6J88_RS13210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6J88_RS13215	COG3623	hexulose-6-phosphate isomerase
I6J88_RS13220	COG0235	Class ii aldolase
I6J88_RS13225	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS13235	COG1454	alcohol dehydrogenase
I6J88_RS13240	COG3276	selenocysteine insertion sequence binding
I6J88_RS13250	COG0625	glutathione transferase activity
I6J88_RS13255	COG1566	PFAM secretion protein HlyD family protein
I6J88_RS13265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS13265	COG2213	PTS system mannitol-specific
I6J88_RS13275	COG3722	fumarate hydratase activity
I6J88_RS13295	COG5295	Hep Hag repeat protein
I6J88_RS13300	COG1620	l-lactate permease
I6J88_RS13305	COG2186	Transcriptional regulator
I6J88_RS13315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J88_RS13320	COG1045	serine acetyltransferase
I6J88_RS13335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J88_RS13340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J88_RS13350	COG4942	peptidase
I6J88_RS13355	COG2861	carbohydrate metabolic process
I6J88_RS13360	COG1216	Glycosyl transferase, family 2
I6J88_RS13370	COG0156	8-amino-7-oxononanoate synthase activity
I6J88_RS13380	COG0859	PFAM glycosyl transferase family 9
I6J88_RS13385	COG0859	PFAM glycosyl transferase family 9
I6J88_RS13390	COG3307	-O-antigen
I6J88_RS13395	COG1216	Glycosyl transferase, family 2
I6J88_RS13400	COG1442	glycosyl transferase family 8
I6J88_RS13405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J88_RS13420	COG0515	serine threonine protein kinase
I6J88_RS13425	COG0438	transferase activity, transferring glycosyl groups
I6J88_RS13430	COG0859	PFAM glycosyl transferase family 9
I6J88_RS13435	COG1519	Transferase
I6J88_RS13465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J88_RS13490	COG1561	YicC-like family, N-terminal region
I6J88_RS13495	COG3645	SOS response
I6J88_RS13500	COG2860	membrane
I6J88_RS13510	COG0194	GDP metabolic process
I6J88_RS13520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J88_RS13525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J88_RS13530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J88_RS13535	COG0786	glutamate:sodium symporter activity
I6J88_RS13540	COG2233	PERMEase
I6J88_RS13545	COG2982	Protein involved in outer membrane biogenesis
I6J88_RS13555	COG1940	carbohydrate kinase activity
I6J88_RS13560	COG0191	fructose-bisphosphate aldolase activity
I6J88_RS13570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS13570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS13575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS13580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS13580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS13580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS13585	COG3711	transcriptional antiterminator
I6J88_RS13590	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J88_RS13595	COG2211	Major facilitator Superfamily
I6J88_RS13615	COG0697	spore germination
I6J88_RS13620	COG1464	Belongs to the NlpA lipoprotein family
I6J88_RS13650	COG2252	PERMEase
I6J88_RS13660	COG2271	Major facilitator Superfamily
I6J88_RS13665	COG2271	Major facilitator Superfamily
I6J88_RS13670	COG3851	Histidine kinase
I6J88_RS13675	COG2197	response regulator
I6J88_RS13680	COG0440	acetolactate synthase activity
I6J88_RS13685	COG0028	Belongs to the TPP enzyme family
I6J88_RS13695	COG2814	Major facilitator Superfamily
I6J88_RS13700	COG0641	radical SAM
I6J88_RS13710	COG2149	membrane
I6J88_RS13715	COG3119	arylsulfatase activity
I6J88_RS13720	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J88_RS13725	COG2207	Transcriptional regulator
I6J88_RS13745	COG5645	(Lipo)protein
I6J88_RS13750	COG0823	Involved in the tonB-independent uptake of proteins
I6J88_RS13755	COG0644	oxidoreductase
I6J88_RS13760	COG2271	Major facilitator Superfamily
I6J88_RS13770	COG0800	Aldolase
I6J88_RS13775	COG3734	2-keto-3-deoxy-galactonokinase
I6J88_RS13780	COG2186	Transcriptional regulator
I6J88_RS13790	COG0561	phosphatase activity
I6J88_RS13795	COG3753	Protein conserved in bacteria
I6J88_RS13800	COG0187	DNA topoisomerase II activity
I6J88_RS13810	COG0592	DNA-directed DNA polymerase activity
I6J88_RS13860	COG0814	amino acid
I6J88_RS13875	COG2091	lysine biosynthetic process via aminoadipic acid
I6J88_RS13880	COG0431	NADPH-dependent FMN reductase
I6J88_RS13885	COG2252	PERMEase
I6J88_RS13890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J88_RS13900	COG0363	glucosamine-6-phosphate deaminase activity
I6J88_RS13905	COG2382	esterase
I6J88_RS13910	COG4580	involved in the transport of maltose and maltodextrins
I6J88_RS13915	COG2723	6-phospho-beta-galactosidase activity
I6J88_RS13920	COG2190	(PTS) system
I6J88_RS13920	COG1263	PTS System
I6J88_RS13920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS13925	COG3711	transcriptional antiterminator
I6J88_RS13930	COG0704	Plays a role in the regulation of phosphate uptake
I6J88_RS13935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J88_RS13940	COG0581	inorganic phosphate transmembrane transporter activity
I6J88_RS13945	COG0573	inorganic phosphate transmembrane transporter activity
I6J88_RS13950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J88_RS14005	COG3312	ion transport
I6J88_RS14020	COG0716	FMN binding
I6J88_RS14025	COG1522	sequence-specific DNA binding
I6J88_RS14055	COG1129	ABC transporter
I6J88_RS14060	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS14065	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS14070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS14075	COG1609	Transcriptional regulator
I6J88_RS14080	COG0477	Major facilitator Superfamily
I6J88_RS14085	COG2186	Transcriptional regulator
I6J88_RS14125	COG3085	chromosome segregation
I6J88_RS14130	COG0606	chelatase, subunit chli
I6J88_RS14150	COG3978	acetolactate synthase activity
I6J88_RS14155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J88_RS14160	COG0129	dihydroxy-acid dehydratase activity
I6J88_RS14165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J88_RS14170	COG0583	DNA-binding transcription factor activity
I6J88_RS14180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J88_RS14185	COG0210	DNA helicase
I6J88_RS14200	COG3118	belongs to the thioredoxin family
I6J88_RS14210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J88_RS14215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J88_RS14220	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J88_RS14225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J88_RS14230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J88_RS14235	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J88_RS14240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J88_RS14245	COG0456	acetyltransferase
I6J88_RS14250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J88_RS14255	COG2244	polysaccharide biosynthetic process
I6J88_RS14275	COG1113	amino acid transport
I6J88_RS14300	COG0641	radical SAM
I6J88_RS14305	COG3119	arylsulfatase activity
I6J88_RS14310	COG3071	HemY protein
I6J88_RS14315	COG2959	enzyme of heme biosynthesis
I6J88_RS14320	COG1587	Uroporphyrinogen-III synthase
I6J88_RS14330	COG3072	Adenylate cyclase
I6J88_RS14345	COG5567	small periplasmic lipoprotein
I6J88_RS14355	COG3159	Protein conserved in bacteria
I6J88_RS14365	COG1011	Hydrolase
I6J88_RS14370	COG0210	DNA helicase
I6J88_RS14375	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6J88_RS14380	COG3698	Phosphodiester glycosidase
I6J88_RS14385	COG0598	Magnesium transport protein CorA
I6J88_RS14400	COG2962	Rard protein
I6J88_RS14405	COG2050	protein possibly involved in aromatic compounds catabolism
I6J88_RS14410	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6J88_RS14415	COG0514	ATP-dependent DNA helicase (RecQ)
I6J88_RS14420	COG1280	lysine exporter protein (LysE YggA)
I6J88_RS14425	COG1280	lysine exporter protein (LysE YggA)
I6J88_RS14430	COG2267	carboxylic ester hydrolase activity
I6J88_RS14435	COG0561	phosphatase activity
I6J88_RS14440	COG0697	spore germination
I6J88_RS14445	COG0583	DNA-binding transcription factor activity
I6J88_RS14460	COG3157	Type VI secretion system effector, Hcp
I6J88_RS14465	COG3157	Type VI secretion system effector, Hcp
I6J88_RS14475	COG1263	PTS System
I6J88_RS14475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS14475	COG2190	(PTS) system
I6J88_RS14480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J88_RS14485	COG1737	Transcriptional regulator
I6J88_RS14490	COG0583	DNA-binding transcription factor activity
I6J88_RS14495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J88_RS14505	COG0549	Belongs to the carbamate kinase family
I6J88_RS14510	COG1304	FMN binding
I6J88_RS14515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J88_RS14525	COG1335	isochorismatase
I6J88_RS14530	COG0412	Dienelactone hydrolase
I6J88_RS14535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6J88_RS14555	COG0800	Aldolase
I6J88_RS14560	COG3734	2-keto-3-deoxy-galactonokinase
I6J88_RS14565	COG1414	Transcriptional regulator
I6J88_RS14570	COG1322	Protein conserved in bacteria
I6J88_RS14580	COG3165	ubiquinone biosynthetic process from chorismate
I6J88_RS14590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J88_RS14600	COG0805	protein transport
I6J88_RS14615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J88_RS14620	COG0543	2 iron, 2 sulfur cluster binding
I6J88_RS14630	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J88_RS14630	COG1024	Enoyl-CoA hydratase
I6J88_RS14640	COG1739	Uncharacterized protein family UPF0029
I6J88_RS14645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J88_RS14650	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6J88_RS14680	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6J88_RS14685	COG0746	molybdenum cofactor guanylyltransferase activity
I6J88_RS14690	COG3084	Protein conserved in bacteria
I6J88_RS14695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J88_RS14700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J88_RS14705	COG5339	Protein conserved in bacteria
I6J88_RS14710	COG0204	Acyl-transferase
I6J88_RS14715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J88_RS14715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J88_RS14730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J88_RS14740	COG2204	response regulator
I6J88_RS14745	COG3852	Histidine kinase
I6J88_RS14750	COG0174	glutamine synthetase
I6J88_RS14755	COG1217	gtp-binding protein TYPA
I6J88_RS14760	COG2188	Transcriptional regulator
I6J88_RS14765	COG1082	Xylose isomerase domain protein TIM barrel
I6J88_RS14770	COG2271	Major facilitator Superfamily
I6J88_RS14775	COG1349	DNA-binding transcription factor activity
I6J88_RS14780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS14785	COG2084	Dehydrogenase
I6J88_RS14790	COG3684	Belongs to the aldolase LacD family
I6J88_RS14795	COG1063	alcohol dehydrogenase
I6J88_RS14805	COG0477	Major facilitator Superfamily
I6J88_RS14815	COG1011	Hydrolase
I6J88_RS14830	COG0456	acetyltransferase
I6J88_RS14840	COG4680	protein conserved in bacteria
I6J88_RS14855	COG2864	formate dehydrogenase
I6J88_RS14860	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS14920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J88_RS14930	COG2258	MOSC domain
I6J88_RS14935	COG2205	protein histidine kinase activity
I6J88_RS14940	COG0745	RESPONSE REGULATOR receiver
I6J88_RS14945	COG3678	ATP-independent chaperone mediated protein folding
I6J88_RS14960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J88_RS14980	COG3152	Membrane
I6J88_RS14985	COG3691	Protein conserved in bacteria
I6J88_RS14990	COG0589	response to stress
I6J88_RS15000	COG1494	fructose-1,6-bisphosphatase
I6J88_RS15010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J88_RS15025	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J88_RS15040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J88_RS15045	COG1609	Transcriptional regulator
I6J88_RS15050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J88_RS15060	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6J88_RS15070	COG0626	cystathionine gamma-synthase activity
I6J88_RS15075	COG0460	homoserine dehydrogenase
I6J88_RS15075	COG0527	aspartate kinase activity
I6J88_RS15085	COG0737	Belongs to the 5'-nucleotidase family
I6J88_RS15090	COG0737	Belongs to the 5'-nucleotidase family
I6J88_RS15100	COG0737	Belongs to the 5'-nucleotidase family
I6J88_RS15105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J88_RS15115	COG0697	spore germination
I6J88_RS15120	COG3738	Protein conserved in bacteria
I6J88_RS15125	COG0371	Dehydrogenase
I6J88_RS15130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J88_RS15135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J88_RS15135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS15135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS15140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS15145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS15150	COG1882	Formate acetyltransferase
I6J88_RS15155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J88_RS15160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J88_RS15165	COG2207	Transcriptional regulator
I6J88_RS15170	COG2194	sulfuric ester hydrolase activity
I6J88_RS15185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J88_RS15190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J88_RS15200	COG4948	Mandelate Racemase Muconate Lactonizing
I6J88_RS15205	COG2271	Major facilitator Superfamily
I6J88_RS15210	COG0583	DNA-binding transcription factor activity
I6J88_RS15220	COG1473	amidohydrolase
I6J88_RS15225	COG0477	Major facilitator Superfamily
I6J88_RS15245	COG4206	TonB-dependent receptor
I6J88_RS15275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J88_RS15280	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J88_RS15280	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J88_RS15315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J88_RS15320	COG0250	Participates in transcription elongation, termination and antitermination
I6J88_RS15355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J88_RS15365	COG2104	thiamine diphosphate biosynthetic process
I6J88_RS15370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J88_RS15380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J88_RS15405	COG3068	Protein conserved in bacteria
I6J88_RS15420	COG3678	ATP-independent chaperone mediated protein folding
I6J88_RS15425	COG4191	Histidine kinase
I6J88_RS15430	COG2204	response regulator
I6J88_RS15435	COG0151	Belongs to the GarS family
I6J88_RS15470	COG0456	acetyltransferase
I6J88_RS15480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J88_RS15485	COG2224	Isocitrate lyase
I6J88_RS15495	COG1414	Transcriptional regulator
I6J88_RS15500	COG0646	methionine synthase
I6J88_RS15500	COG1410	methionine synthase
I6J88_RS15515	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J88_RS15560	COG1187	pseudouridine synthase activity
I6J88_RS15570	COG0527	aspartate kinase activity
I6J88_RS15595	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J88_RS15610	COG3833	ABC-type maltose transport systems, permease component
I6J88_RS15615	COG1175	transmembrane transport
I6J88_RS15620	COG2182	Extracellular solute-binding protein
I6J88_RS15625	COG3842	ATPase activity
I6J88_RS15655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J88_RS15665	COG0534	Mate efflux family protein
I6J88_RS15670	COG3237	CsbD-like
I6J88_RS15675	COG0735	belongs to the Fur family
I6J88_RS15680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J88_RS15690	COG0604	alcohol dehydrogenase
I6J88_RS15695	COG1053	succinate dehydrogenase
I6J88_RS15700	COG0477	Major facilitator Superfamily
I6J88_RS15705	COG1024	Enoyl-CoA hydratase
I6J88_RS15715	COG1609	Transcriptional regulator
I6J88_RS15720	COG0305	Participates in initiation and elongation during chromosome replication
I6J88_RS15725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J88_RS15730	COG1448	Aminotransferase
I6J88_RS15735	COG0567	Dehydrogenase, E1 component
I6J88_RS15745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J88_RS15750	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J88_RS15755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J88_RS15760	COG0471	metal ion transport
I6J88_RS15765	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J88_RS15770	COG2204	response regulator
I6J88_RS15780	COG3700	Belongs to the class B bacterial acid phosphatase family
I6J88_RS15785	COG0432	Pfam Uncharacterised protein family UPF0047
I6J88_RS15790	COG2315	Protein conserved in bacteria
I6J88_RS15795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J88_RS15800	COG0629	single-stranded DNA binding
I6J88_RS15810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6J88_RS15815	COG2207	Transcriptional regulator
I6J88_RS15820	COG0789	Transcriptional regulator
I6J88_RS15825	COG2252	PERMEase
I6J88_RS15830	COG0025	NhaP-type Na H and K H
I6J88_RS15835	COG0583	DNA-binding transcription factor activity
I6J88_RS15840	COG1380	Effector of murein hydrolase LrgA
I6J88_RS15845	COG1346	cytolysis
I6J88_RS15855	COG3162	membrane
I6J88_RS15860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J88_RS15870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J88_RS15875	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS15880	COG3301	Polysulphide reductase, NrfD
I6J88_RS15885	COG1138	Cytochrome C-type biogenesis protein
I6J88_RS15890	COG3088	subunit of a heme lyase
I6J88_RS15895	COG4235	cytochrome complex assembly
I6J88_RS15900	COG1301	dicarboxylic acid transport
I6J88_RS15905	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6J88_RS15910	COG4608	Belongs to the ABC transporter superfamily
I6J88_RS15915	COG0444	Belongs to the ABC transporter superfamily
I6J88_RS15920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J88_RS15925	COG0601	transmembrane transport
I6J88_RS15940	COG1538	Outer membrane efflux protein
I6J88_RS15945	COG1289	transmembrane transporter activity
I6J88_RS15950	COG1566	PFAM secretion protein HlyD family protein
I6J88_RS15960	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J88_RS15965	COG1940	carbohydrate kinase activity
I6J88_RS15970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J88_RS15975	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS15980	COG1129	ABC transporter
I6J88_RS15985	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS15990	COG1737	Transcriptional regulator
I6J88_RS15995	COG0698	ribose 5-phosphate isomerase
I6J88_RS16005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J88_RS16010	COG0456	acetyltransferase
I6J88_RS16015	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6J88_RS16020	COG3454	Phosphonate metabolism
I6J88_RS16025	COG4778	phosphonate C-P lyase system protein PhnL
I6J88_RS16030	COG4107	phosphonate C-P lyase system protein PhnK
I6J88_RS16035	COG3627	carbon phosphorus lyase activity
I6J88_RS16040	COG3626	phosphonate metabolism
I6J88_RS16045	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6J88_RS16050	COG3624	Phosphonate C-P lyase system protein PhnG
I6J88_RS16055	COG2188	Transcriptional regulator
I6J88_RS16060	COG3639	organic phosphonate transmembrane transporter activity
I6J88_RS16065	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6J88_RS16075	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6J88_RS16080	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J88_RS16095	COG0477	Major facilitator Superfamily
I6J88_RS16105	COG0642	Histidine kinase
I6J88_RS16110	COG0745	RESPONSE REGULATOR receiver
I6J88_RS16115	COG2194	sulfuric ester hydrolase activity
I6J88_RS16120	COG0531	amino acid
I6J88_RS16125	COG2207	Transcriptional regulator
I6J88_RS16130	COG1982	Orn Lys Arg decarboxylase major
I6J88_RS16135	COG2169	Transcriptional regulator
I6J88_RS16140	COG1486	melibiose metabolic process
I6J88_RS16145	COG3647	Membrane
I6J88_RS16150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J88_RS16150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J88_RS16155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J88_RS16160	COG4565	transcriptional regulatory protein
I6J88_RS16165	COG3290	protein histidine kinase activity
I6J88_RS16170	COG3592	Divergent 4Fe-4S mono-cluster
I6J88_RS16175	COG2388	GCN5-related N-acetyl-transferase
I6J88_RS16190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J88_RS16195	COG3104	oligopeptide transport
I6J88_RS16200	COG1982	Orn Lys Arg decarboxylase major
I6J88_RS16205	COG0531	amino acid
I6J88_RS16210	COG3710	Transcriptional regulator
I6J88_RS16215	COG2200	EAL domain
I6J88_RS16215	COG2771	luxR family
I6J88_RS16225	COG4584	PFAM Integrase catalytic
I6J88_RS16230	COG1484	DNA-dependent DNA replication
I6J88_RS16265	COG2003	Belongs to the UPF0758 family
I6J88_RS16290	COG2378	regulation of single-species biofilm formation
I6J88_RS16295	COG3596	GTP binding
I6J88_RS16320	COG4771	TonB-dependent receptor
I6J88_RS16345	COG3969	phosphoadenosine phosphosulfate
I6J88_RS16500	COG2194	sulfuric ester hydrolase activity
I6J88_RS16505	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J88_RS16505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J88_RS16510	COG0582	viral genome integration into host DNA
I6J88_RS16520	COG1309	transcriptional regulator
I6J88_RS16525	COG4232	protein-disulfide reductase activity
I6J88_RS16535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J88_RS16540	COG1027	Aspartate ammonia-lyase
I6J88_RS16545	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6J88_RS16550	COG0531	amino acid
I6J88_RS16575	COG1509	lysine 2,3-aminomutase activity
I6J88_RS16585	COG5510	response to toxic substance
I6J88_RS16590	COG5510	response to toxic substance
I6J88_RS16595	COG2076	Multidrug Resistance protein
I6J88_RS16600	COG3040	lipid binding
I6J88_RS16605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J88_RS16620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J88_RS16625	COG1053	succinate dehydrogenase
I6J88_RS16635	COG0531	amino acid
I6J88_RS16640	COG3264	Mechanosensitive ion channel
I6J88_RS16640	COG1511	domain protein
I6J88_RS16680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J88_RS16685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J88_RS16685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J88_RS16690	COG0802	atpase or kinase
I6J88_RS16695	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J88_RS16715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J88_RS16720	COG0330	HflC and HflK could
I6J88_RS16725	COG0330	HflC and HflK could
I6J88_RS16730	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6J88_RS16745	COG0557	exoribonuclease II activity
I6J88_RS16750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J88_RS16755	COG3789	protein conserved in bacteria
I6J88_RS16760	COG1842	Phage shock protein A
I6J88_RS16770	COG3766	membrane
I6J88_RS16775	COG5463	Belongs to the UPF0441 family
I6J88_RS16780	COG0754	glutathionylspermidine amidase activity
I6J88_RS16785	COG1960	acyl-CoA dehydrogenase activity
I6J88_RS16795	COG3650	response to hydrogen peroxide
I6J88_RS16800	COG1073	alpha beta
I6J88_RS16815	COG3037	sugar-specific permease SgaT UlaA
I6J88_RS16820	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J88_RS16860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J88_RS16880	COG2271	Major facilitator Superfamily
I6J88_RS16890	COG4670	ketone body catabolic process
I6J88_RS16895	COG1024	Enoyl-CoA hydratase
I6J88_RS16910	COG1309	transcriptional regulator
I6J88_RS16915	COG3061	Opacity-associated protein A
I6J88_RS16920	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J88_RS16925	COG1113	amino acid transport
I6J88_RS16935	COG0697	spore germination
I6J88_RS16940	COG0702	epimerase
I6J88_RS16945	COG1733	regulation of RNA biosynthetic process
I6J88_RS16950	COG0737	Belongs to the 5'-nucleotidase family
I6J88_RS16955	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6J88_RS16960	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6J88_RS16970	COG1253	flavin adenine dinucleotide binding
I6J88_RS16980	COG0729	surface antigen
I6J88_RS16985	COG2911	Protein conserved in bacteria
I6J88_RS16990	COG2105	PFAM AIG2 family protein
I6J88_RS16995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J88_RS17000	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS17005	COG1129	ABC transporter
I6J88_RS17010	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS17015	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J88_RS17025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J88_RS17030	COG3028	Belongs to the UPF0307 family
I6J88_RS17035	COG0312	modulator of DNA gyrase
I6J88_RS17040	COG3783	Cytochrome b(562)
I6J88_RS17045	COG0602	queuosine metabolic process
I6J88_RS17050	COG1328	CTP reductase activity
I6J88_RS17055	COG0366	Alpha amylase catalytic
I6J88_RS17060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS17060	COG1263	PTS System
I6J88_RS17065	COG1609	Transcriptional regulator
I6J88_RS17075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J88_RS17080	COG0251	oxidation-reduction process
I6J88_RS17100	COG1438	arginine binding
I6J88_RS17105	COG1288	antiporter activity
I6J88_RS17110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J88_RS17115	COG0549	Belongs to the carbamate kinase family
I6J88_RS17125	COG2731	YhcH YjgK YiaL family protein
I6J88_RS17130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J88_RS17135	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6J88_RS17140	COG0456	acetyltransferase
I6J88_RS17150	COG0525	valine-tRNA ligase activity
I6J88_RS17155	COG2927	DNA polymerase III (CHI subunit)
I6J88_RS17165	COG0795	lipopolysaccharide-transporting ATPase activity
I6J88_RS17170	COG0795	lipopolysaccharide-transporting ATPase activity
I6J88_RS17175	COG0433	COG0433 Predicted ATPase
I6J88_RS17180	COG1609	Transcriptional regulator
I6J88_RS17185	COG2610	gluconate transmembrane transporter activity
I6J88_RS17190	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS17195	COG1063	alcohol dehydrogenase
I6J88_RS17200	COG3265	gluconokinase activity
I6J88_RS17205	COG1064	alcohol dehydrogenase
I6J88_RS17215	COG0582	viral genome integration into host DNA
I6J88_RS17220	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J88_RS17220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J88_RS17230	COG1484	DNA-dependent DNA replication
I6J88_RS17235	COG4584	PFAM Integrase catalytic
I6J88_RS17355	COG2259	Doxx family
I6J88_RS17360	COG1304	FMN binding
I6J88_RS17370	COG1309	transcriptional regulator
I6J88_RS17375	COG4372	Transposase
I6J88_RS17380	COG3436	PFAM IS66 Orf2 family protein
I6J88_RS17415	COG2274	protein secretion by the type I secretion system
I6J88_RS17435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J88_RS17445	COG0745	RESPONSE REGULATOR receiver
I6J88_RS17450	COG5002	protein histidine kinase activity
I6J88_RS17545	COG2610	gluconate transmembrane transporter activity
I6J88_RS17550	COG0583	DNA-binding transcription factor activity
I6J88_RS17560	COG2076	Multidrug Resistance protein
I6J88_RS17575	COG4869	propanediol catabolic process
I6J88_RS17585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J88_RS17590	COG1882	Formate acetyltransferase
I6J88_RS17595	COG1454	alcohol dehydrogenase
I6J88_RS17595	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS17605	COG1454	alcohol dehydrogenase
I6J88_RS17605	COG1012	belongs to the aldehyde dehydrogenase family
I6J88_RS17645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J88_RS17650	COG1757	Na H antiporter
I6J88_RS17685	COG3596	GTP binding
I6J88_RS17690	COG2378	regulation of single-species biofilm formation
I6J88_RS17715	COG2003	Belongs to the UPF0758 family
I6J88_RS17745	COG2390	Transcriptional regulator
I6J88_RS17750	COG2610	gluconate transmembrane transporter activity
I6J88_RS17755	COG0129	dihydroxy-acid dehydratase activity
I6J88_RS17760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J88_RS17765	COG1414	Transcriptional regulator
I6J88_RS17770	COG1349	DNA-binding transcription factor activity
I6J88_RS17775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J88_RS17780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS17785	COG0434	BtpA family
I6J88_RS17790	COG3775	system Galactitol-specific IIC component
I6J88_RS17795	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J88_RS17800	COG1363	Peptidase, m42
I6J88_RS17815	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J88_RS17820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J88_RS17825	COG3153	acetyltransferase
I6J88_RS17850	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6J88_RS17855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6J88_RS17860	COG0582	viral genome integration into host DNA
I6J88_RS17865	COG4974	Belongs to the 'phage' integrase family
I6J88_RS17875	COG3539	Fimbrial protein
I6J88_RS17880	COG3121	Chaperone
I6J88_RS17885	COG3188	usher protein
I6J88_RS17890	COG3539	Fimbrial protein
I6J88_RS17895	COG3539	Fimbrial protein
I6J88_RS17900	COG3539	Fimbrial protein
I6J88_RS17905	COG2610	gluconate transmembrane transporter activity
I6J88_RS17915	COG0246	Mannitol dehydrogenase
I6J88_RS17920	COG2186	Transcriptional regulator
I6J88_RS17935	COG0583	DNA-binding transcription factor activity
I6J88_RS17940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J88_RS17945	COG0700	Nucleoside recognition
I6J88_RS17950	COG3366	ferrous iron transmembrane transporter activity
I6J88_RS17960	COG0477	Major facilitator Superfamily
I6J88_RS17975	COG1924	4 iron, 4 sulfur cluster binding
I6J88_RS17980	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6J88_RS17985	COG2733	membrane
I6J88_RS17995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J88_RS18010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J88_RS18015	COG0732	type I restriction modification DNA specificity domain
I6J88_RS18020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J88_RS18025	COG1715	Restriction endonuclease
I6J88_RS18040	COG0523	cobalamin synthesis protein
I6J88_RS18045	COG2879	small protein
I6J88_RS18050	COG1966	Carbon starvation protein
I6J88_RS18055	COG0840	transmembrane signaling receptor activity
I6J88_RS18060	COG2271	Major facilitator Superfamily
I6J88_RS18065	COG1802	Transcriptional regulator
I6J88_RS18070	COG1063	alcohol dehydrogenase
I6J88_RS18085	COG1484	DNA-dependent DNA replication
I6J88_RS18100	COG2966	Psort location CytoplasmicMembrane, score
I6J88_RS18105	COG2197	response regulator
I6J88_RS18110	COG2197	response regulator
I6J88_RS18115	COG4114	ferric iron reductase
I6J88_RS18145	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6J88_RS18150	COG0456	acetyltransferase
I6J88_RS18155	COG1011	Hydrolase
I6J88_RS18190	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J88_RS18195	COG5532	Uncharacterized conserved protein (DUF2303)
I6J88_RS18235	COG1846	Transcriptional regulator
I6J88_RS18250	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6J88_RS18260	COG1403	HNH endonuclease
I6J88_RS18265	COG0484	heat shock protein binding
I6J88_RS18305	COG3772	lysozyme
I6J88_RS18330	COG4220	transposase activity
I6J88_RS18350	COG1030	water channel activity
I6J88_RS18400	COG1196	nuclear chromosome segregation
I6J88_RS18435	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6J88_RS18480	COG2823	Periplasmic or secreted lipoprotein
I6J88_RS18490	COG4667	esterase of the alpha-beta hydrolase superfamily
I6J88_RS18495	COG0084	hydrolase, TatD family'
I6J88_RS18500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J88_RS18505	COG1328	CTP reductase activity
I6J88_RS18530	COG3550	peptidyl-serine autophosphorylation
I6J88_RS18540	COG3726	membrane protein affecting hemolysin expression
I6J88_RS18545	COG0560	Phosphoserine phosphatase
I6J88_RS18550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J88_RS18555	COG3172	ATPase kinase involved in NAD metabolism
I6J88_RS18555	COG1056	cytidyltransferase-related domain
I6J88_RS18560	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6J88_RS18570	COG0488	(ABC) transporter
I6J88_RS18575	COG0741	lytic transglycosylase activity
I6J88_RS18595	COG3708	Transcriptional regulator
I6J88_RS18595	COG2207	Transcriptional regulator
I6J88_RS18600	COG3045	CreA protein
I6J88_RS18605	COG0745	RESPONSE REGULATOR receiver
I6J88_RS18610	COG2205	protein histidine kinase activity
I6J88_RS18615	COG4452	Inner membrane protein CreD
I6J88_RS18620	COG0745	RESPONSE REGULATOR receiver
I6J88_RS18630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6J88_RS18640	COG0527	aspartate kinase activity
I6J88_RS18640	COG0460	homoserine dehydrogenase
I6J88_RS18650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J88_RS18665	COG1115	amino acid carrier protein
I6J88_RS18675	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J88_RS18680	COG1584	GPR1 FUN34 yaaH family protein
I6J88_RS18685	COG4735	regulation of single-species biofilm formation
I6J88_RS18715	COG3119	arylsulfatase activity
I6J88_RS18730	COG0583	DNA-binding transcription factor activity
I6J88_RS18745	COG0196	riboflavin kinase activity
I6J88_RS18760	COG1047	Peptidyl-prolyl cis-trans
I6J88_RS18785	COG0505	Belongs to the CarA family
I6J88_RS18790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J88_RS18840	COG0644	oxidoreductase
I6J88_RS18845	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J88_RS18850	COG2271	Major facilitator Superfamily
I6J88_RS18865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J88_RS18895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J88_RS18900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J88_RS18910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6J88_RS18915	COG0564	pseudouridine synthase activity
I6J88_RS18925	COG0417	DNA replication proofreading
I6J88_RS18930	COG0235	Class ii aldolase
I6J88_RS18945	COG4977	sequence-specific DNA binding
I6J88_RS18950	COG0586	Pfam SNARE associated Golgi protein
I6J88_RS18960	COG1178	ABC-type Fe3 transport system permease component
I6J88_RS18965	COG4143	(ABC) transporter
I6J88_RS19005	COG0583	DNA-binding transcription factor activity
I6J88_RS19015	COG0028	Belongs to the TPP enzyme family
I6J88_RS19020	COG0440	acetolactate synthase activity
I6J88_RS19030	COG1609	Transcriptional regulator
I6J88_RS19045	COG3116	cell division
I6J88_RS19050	COG0768	penicillin binding
I6J88_RS19055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J88_RS19060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J88_RS19075	COG0772	Belongs to the SEDS family
I6J88_RS19090	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J88_RS19095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J88_RS19100	COG0849	cell division
I6J88_RS19105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J88_RS19125	COG0494	nUDIX hydrolase
I6J88_RS19140	COG0237	dephospho-CoA kinase activity
I6J88_RS19155	COG1459	type II secretion system
I6J88_RS19160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J88_RS19165	COG4969	Belongs to the N-Me-Phe pilin family
I6J88_RS19170	COG0157	Belongs to the NadC ModD family
I6J88_RS19175	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J88_RS19180	COG3725	Membrane protein required for beta-lactamase induction
I6J88_RS19185	COG1113	amino acid transport
I6J88_RS19190	COG3157	Type VI secretion system effector, Hcp
I6J88_RS19220	COG2186	Transcriptional regulator
I6J88_RS19225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J88_RS19230	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J88_RS19235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J88_RS19240	COG3064	Membrane
I6J88_RS19245	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6J88_RS19270	COG2132	Multicopper oxidase
I6J88_RS19275	COG4993	Dehydrogenase
I6J88_RS19280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J88_RS19285	COG0288	reversible hydration of carbon dioxide
I6J88_RS19290	COG1131	(ABC) transporter
I6J88_RS19295	COG0842	Transport permease protein
I6J88_RS19300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J88_RS19305	COG0726	polysaccharide deacetylase
I6J88_RS19315	COG5464	transposase or invertase
I6J88_RS19320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J88_RS19330	COG3539	Fimbrial protein
I6J88_RS19335	COG3539	Fimbrial protein
I6J88_RS19340	COG3539	Fimbrial protein
I6J88_RS19345	COG3539	Fimbrial protein
I6J88_RS19350	COG3188	usher protein
I6J88_RS19355	COG3121	Chaperone
I6J88_RS19360	COG3539	Fimbrial protein
I6J88_RS19365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J88_RS19370	COG0617	tRNA 3'-terminal CCA addition
I6J88_RS19375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J88_RS19380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J88_RS19390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6J88_RS19395	COG1643	Atp-dependent helicase
I6J88_RS19400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J88_RS19405	COG4774	siderophore transport
I6J88_RS19410	COG1120	ATPase activity
I6J88_RS19415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J88_RS19420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS19445	COG2860	membrane
I6J88_RS19450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J88_RS19465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J88_RS19490	COG0024	Methionine aminopeptidase
I6J88_RS19515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J88_RS19520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J88_RS19525	COG0575	Belongs to the CDS family
I6J88_RS19530	COG0750	zinc metalloprotease
I6J88_RS19540	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6J88_RS19545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J88_RS19570	COG0587	DNA-directed DNA polymerase activity
I6J88_RS19580	COG1982	Orn Lys Arg decarboxylase major
I6J88_RS19585	COG0346	lactoylglutathione lyase activity
I6J88_RS19590	COG0037	tRNA processing
I6J88_RS19595	COG4568	rho-dependent transcription termination
I6J88_RS19605	COG4681	YaeQ
I6J88_RS19610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J88_RS19615	COG3015	lipoprotein NlpE involved in copper resistance
I6J88_RS19620	COG0791	NLP P60 protein
I6J88_RS19630	COG1720	tRNA m6t6A37 methyltransferase activity
I6J88_RS19640	COG1464	Belongs to the NlpA lipoprotein family
I6J88_RS19645	COG2011	ABC-type metal ion transport system permease component
I6J88_RS19655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J88_RS19690	COG0656	L-ascorbic acid biosynthetic process
I6J88_RS19695	COG0583	DNA-binding transcription factor activity
I6J88_RS19705	COG2226	methyltransferase
I6J88_RS19710	COG1388	LysM domain
I6J88_RS19710	COG0741	lytic transglycosylase activity
I6J88_RS19720	COG2226	methyltransferase
I6J88_RS19730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J88_RS19825	COG3501	Rhs element vgr protein
I6J88_RS19865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J88_RS19875	COG1960	acyl-CoA dehydrogenase activity
I6J88_RS19885	COG0121	glutamine amidotransferase
I6J88_RS19890	COG3034	peptidoglycan biosynthetic process
I6J88_RS19895	COG0791	NLP P60 protein
I6J88_RS19925	COG0454	-acetyltransferase
I6J88_RS19930	COG1690	Belongs to the RtcB family
I6J88_RS19935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J88_RS19940	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J88_RS19960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J88_RS20005	COG3477	response to acidic pH
I6J88_RS20015	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6J88_RS20070	COG1902	pentaerythritol trinitrate reductase activity
I6J88_RS20075	COG1073	alpha beta
I6J88_RS20080	COG0583	DNA-binding transcription factor activity
I6J88_RS20090	COG0667	Aldo Keto reductase
I6J88_RS20095	COG0656	L-ascorbic acid biosynthetic process
I6J88_RS20100	COG1388	LysM domain
I6J88_RS20105	COG2207	Transcriptional regulator
I6J88_RS20105	COG3708	Transcriptional regulator
I6J88_RS20110	COG0656	L-ascorbic acid biosynthetic process
I6J88_RS20115	COG3059	membrane
I6J88_RS20125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J88_RS20130	COG2207	Transcriptional regulator
I6J88_RS20135	COG0247	lactate metabolic process
I6J88_RS20140	COG1139	Iron-sulfur cluster binding protein
I6J88_RS20145	COG1556	Lactate utilization protein
I6J88_RS20155	COG3468	outer membrane autotransporter barrel domain protein
I6J88_RS20170	COG2771	luxR family
I6J88_RS20170	COG2200	EAL domain
I6J88_RS20175	COG0582	viral genome integration into host DNA
I6J88_RS20180	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6J88_RS20195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J88_RS20200	COG2771	luxR family
I6J88_RS20200	COG2200	EAL domain
I6J88_RS20205	COG0583	DNA-binding transcription factor activity
I6J88_RS20215	COG0666	response to abiotic stimulus
I6J88_RS20225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J88_RS20230	COG1304	FMN binding
I6J88_RS20235	COG0549	Belongs to the carbamate kinase family
I6J88_RS20240	COG0402	S-adenosylhomocysteine deaminase activity
I6J88_RS20245	COG1064	alcohol dehydrogenase
I6J88_RS20255	COG1280	lysine exporter protein (LysE YggA)
I6J88_RS20265	COG3829	transcription factor binding
I6J88_RS20270	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6J88_RS20275	COG0372	Belongs to the citrate synthase family
I6J88_RS20280	COG2079	MmgE PrpD family protein
I6J88_RS20285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J88_RS20290	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J88_RS20295	COG0402	S-adenosylhomocysteine deaminase activity
I6J88_RS20300	COG0110	maltose O-acetyltransferase activity
I6J88_RS20305	COG2223	nitrite transmembrane transporter activity
I6J88_RS20310	COG3250	beta-galactosidase activity
I6J88_RS20315	COG1609	Transcriptional regulator
I6J88_RS20325	COG3122	Protein conserved in bacteria
I6J88_RS20355	COG1215	transferase activity, transferring glycosyl groups
I6J88_RS20360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J88_RS20365	COG4521	taurine ABC transporter
I6J88_RS20375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J88_RS20380	COG2175	clavaminate synthase activity
I6J88_RS20385	COG0113	porphobilinogen synthase activity
I6J88_RS20390	COG3468	outer membrane autotransporter barrel domain protein
I6J88_RS20395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J88_RS20400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J88_RS20405	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J88_RS20425	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J88_RS20440	COG1785	Belongs to the alkaline phosphatase family
I6J88_RS20450	COG3706	GGDEF domain
I6J88_RS20455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J88_RS20475	COG4126	flavin adenine dinucleotide binding
I6J88_RS20500	COG1940	carbohydrate kinase activity
I6J88_RS20505	COG2814	Major facilitator Superfamily
I6J88_RS20510	COG0419	ATPase involved in DNA repair
I6J88_RS20515	COG0420	3'-5' exonuclease activity
I6J88_RS20520	COG0745	RESPONSE REGULATOR receiver
I6J88_RS20525	COG5002	protein histidine kinase activity
I6J88_RS20530	COG1114	Component of the transport system for branched-chain amino acids
I6J88_RS20535	COG1113	amino acid transport
I6J88_RS20540	COG0366	Alpha amylase catalytic
I6J88_RS20560	COG1862	Preprotein translocase
I6J88_RS20565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J88_RS20570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J88_RS20575	COG1403	HNH endonuclease
I6J88_RS20580	COG3248	Nucleoside-binding outer membrane protein
I6J88_RS20585	COG4238	major outer membrane lipoprotein
I6J88_RS20595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J88_RS20595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J88_RS20610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J88_RS20615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J88_RS20620	COG0667	Aldo Keto reductase
I6J88_RS20630	COG0142	geranyltranstransferase activity
I6J88_RS20645	COG0693	protein deglycase activity
I6J88_RS20650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J88_RS20660	COG2814	Major facilitator Superfamily
I6J88_RS20670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J88_RS20675	COG1845	cytochrome c oxidase, subunit III
I6J88_RS20680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J88_RS20685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J88_RS20690	COG2223	nitrite transmembrane transporter activity
I6J88_RS20695	COG3056	Lipoprotein
I6J88_RS20700	COG0271	Belongs to the BolA IbaG family
I6J88_RS20720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J88_RS20725	COG0776	regulation of translation
I6J88_RS20730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J88_RS20735	COG1555	photosystem II stabilization
I6J88_RS20740	COG0824	Thioesterase
I6J88_RS20750	COG4533	DNA binding
I6J88_RS20760	COG1522	sequence-specific DNA binding
I6J88_RS20765	COG1132	(ABC) transporter
I6J88_RS20770	COG1132	(ABC) transporter
I6J88_RS20775	COG0347	Belongs to the P(II) protein family
I6J88_RS20780	COG0004	ammonium transporteR
I6J88_RS20785	COG1946	Acyl-CoA thioesterase
I6J88_RS20790	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6J88_RS20795	COG3695	enzyme binding
I6J88_RS20805	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6J88_RS20810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6J88_RS20820	COG0110	maltose O-acetyltransferase activity
I6J88_RS20835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J88_RS20840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS20845	COG1309	transcriptional regulator
I6J88_RS20850	COG1196	nuclear chromosome segregation
I6J88_RS20850	COG3264	Mechanosensitive ion channel
I6J88_RS20860	COG3923	Primosomal replication protein n
I6J88_RS20865	COG2832	Protein of unknown function (DUF454)
I6J88_RS20875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J88_RS20910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J88_RS20915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J88_RS20915	COG4651	solute:proton antiporter activity
I6J88_RS20920	COG2223	nitrite transmembrane transporter activity
I6J88_RS20925	COG0737	Belongs to the 5'-nucleotidase family
I6J88_RS20930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J88_RS20935	COG3735	TraB family
I6J88_RS20940	COG2217	Heavy metal translocating P-type atpase
I6J88_RS20945	COG2066	Belongs to the glutaminase family
I6J88_RS20950	COG0531	amino acid
I6J88_RS20955	COG0789	Transcriptional regulator
I6J88_RS20980	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J88_RS20985	COG0330	HflC and HflK could
I6J88_RS20990	COG4619	ABC transporter
I6J88_RS20995	COG0390	transport system, permease component
I6J88_RS21000	COG3118	belongs to the thioredoxin family
I6J88_RS21005	COG0300	oxidoreductase activity
I6J88_RS21010	COG2755	lipolytic protein G-D-S-L family
I6J88_RS21015	COG4181	ATPase activity
I6J88_RS21020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J88_RS21040	COG1414	Transcriptional regulator
I6J88_RS21045	COG3960	tartronate-semialdehyde synthase activity
I6J88_RS21050	COG3622	Belongs to the hyi family
I6J88_RS21055	COG2084	Dehydrogenase
I6J88_RS21060	COG1953	Uracil, thiamine, allantoin
I6J88_RS21070	COG2233	PERMEase
I6J88_RS21075	COG1929	Belongs to the glycerate kinase type-1 family
I6J88_RS21080	COG3257	ureidoglycine aminohydrolase activity
I6J88_RS21085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J88_RS21090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J88_RS21095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J88_RS21100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J88_RS21110	COG0549	Belongs to the carbamate kinase family
I6J88_RS21115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J88_RS21120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J88_RS21135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J88_RS21145	COG1988	membrane-bound metal-dependent
I6J88_RS21150	COG2501	S4 domain
I6J88_RS21180	COG0500	methyltransferase
I6J88_RS21185	COG4571	Outer membrane protease
I6J88_RS21195	COG4783	chaperone-mediated protein folding
I6J88_RS21200	COG1215	transferase activity, transferring glycosyl groups
I6J88_RS21205	COG5002	protein histidine kinase activity
I6J88_RS21210	COG0745	RESPONSE REGULATOR receiver
I6J88_RS21215	COG1538	Outer membrane efflux protein
I6J88_RS21220	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS21225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS21230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J88_RS21235	COG1113	amino acid transport
I6J88_RS21240	COG0668	transmembrane transport
I6J88_RS21245	COG0778	Nitroreductase
I6J88_RS21250	COG2315	Protein conserved in bacteria
I6J88_RS21270	COG2977	Belongs to the P-Pant transferase superfamily
I6J88_RS21275	COG4771	TonB-dependent receptor
I6J88_RS21285	COG2382	esterase
I6J88_RS21290	COG3251	PFAM MbtH domain protein
I6J88_RS21295	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J88_RS21295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J88_RS21300	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J88_RS21305	COG1120	ATPase activity
I6J88_RS21310	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS21315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J88_RS21325	COG4592	Periplasmic binding protein
I6J88_RS21330	COG1169	isochorismate synthase
I6J88_RS21335	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J88_RS21340	COG1535	isochorismatase
I6J88_RS21340	COG3433	isochorismatase activity
I6J88_RS21345	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS21350	COG2050	protein possibly involved in aromatic compounds catabolism
I6J88_RS21355	COG1966	Carbon starvation protein
I6J88_RS21360	COG2879	small protein
I6J88_RS21365	COG0371	Dehydrogenase
I6J88_RS21375	COG1475	DNA binding
I6J88_RS21380	COG3969	phosphoadenosine phosphosulfate
I6J88_RS21385	COG0583	DNA-binding transcription factor activity
I6J88_RS21390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J88_RS21395	COG0450	alkyl hydroperoxide reductase
I6J88_RS21400	COG3634	alkyl hydroperoxide reductase activity
I6J88_RS21405	COG0589	response to stress
I6J88_RS21410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J88_RS21415	COG3719	Belongs to the RNase T2 family
I6J88_RS21420	COG0471	metal ion transport
I6J88_RS21435	COG3051	citrate lyase alpha subunit
I6J88_RS21440	COG2301	Belongs to the HpcH HpaI aldolase family
I6J88_RS21450	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6J88_RS21455	COG3290	protein histidine kinase activity
I6J88_RS21460	COG4565	transcriptional regulatory protein
I6J88_RS21465	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J88_RS21485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J88_RS21490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J88_RS21515	COG1686	Belongs to the peptidase S11 family
I6J88_RS21520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J88_RS21525	COG0772	Belongs to the SEDS family
I6J88_RS21530	COG0768	penicillin binding
I6J88_RS21540	COG0799	negative regulation of ribosome biogenesis
I6J88_RS21545	COG0406	alpha-ribazole phosphatase activity
I6J88_RS21555	COG1466	dna polymerase III delta subunit
I6J88_RS21570	COG2888	peptidyl-tyrosine sulfation
I6J88_RS21580	COG1126	abc transporter atp-binding protein
I6J88_RS21585	COG0765	amino acid transport
I6J88_RS21590	COG0765	amino acid transport
I6J88_RS21595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS21605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6J88_RS21610	COG4535	Mg2 and Co2 transporter CorC
I6J88_RS21620	COG1702	phosphate starvation-inducible protein PhoH
I6J88_RS21630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J88_RS21670	COG0367	asparagine synthase
I6J88_RS21675	COG0647	UMP catabolic process
I6J88_RS21680	COG1846	Transcriptional regulator
I6J88_RS21680	COG1940	carbohydrate kinase activity
I6J88_RS21685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J88_RS21695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS21695	COG2190	(PTS) system
I6J88_RS21695	COG1263	PTS System
I6J88_RS21705	COG4382	Mu-like prophage protein Gp16
I6J88_RS21745	COG3409	Peptidoglycan-binding domain 1 protein
I6J88_RS21745	COG3267	Type II secretory pathway component ExeA
I6J88_RS21830	COG4373	Mu-like prophage FluMu protein gp28
I6J88_RS21840	COG2369	cell adhesion
I6J88_RS21960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J88_RS21980	COG0861	Integral membrane protein TerC family
I6J88_RS21985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J88_RS21990	COG1454	alcohol dehydrogenase
I6J88_RS21995	COG3395	kinase activity
I6J88_RS22000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J88_RS22005	COG1349	DNA-binding transcription factor activity
I6J88_RS22025	COG0735	belongs to the Fur family
I6J88_RS22035	COG0716	FMN binding
I6J88_RS22045	COG0596	Alpha beta hydrolase
I6J88_RS22050	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6J88_RS22055	COG0033	Phosphoglucomutase
I6J88_RS22060	COG0531	amino acid
I6J88_RS22065	COG1982	Orn Lys Arg decarboxylase major
I6J88_RS22075	COG0745	RESPONSE REGULATOR receiver
I6J88_RS22080	COG2205	protein histidine kinase activity
I6J88_RS22110	COG3272	Protein of unknown function (DUF1722)
I6J88_RS22115	COG0415	Belongs to the DNA photolyase family
I6J88_RS22125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J88_RS22130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J88_RS22135	COG1984	allophanate hydrolase subunit 2
I6J88_RS22140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J88_RS22150	COG3180	Ammonia monooxygenase
I6J88_RS22160	COG0372	Belongs to the citrate synthase family
I6J88_RS22170	COG2009	succinate dehydrogenase
I6J88_RS22175	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J88_RS22180	COG1053	succinate dehydrogenase
I6J88_RS22185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J88_RS22190	COG0567	Dehydrogenase, E1 component
I6J88_RS22195	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J88_RS22205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J88_RS22215	COG1271	oxidase subunit
I6J88_RS22220	COG1294	oxidase, subunit
I6J88_RS22225	COG4890	Cyd operon protein YbgT
I6J88_RS22230	COG3790	cyd operon protein YbgE
I6J88_RS22235	COG0824	Thioesterase
I6J88_RS22240	COG0811	peptide transport
I6J88_RS22245	COG0848	biopolymer transport protein
I6J88_RS22250	COG3064	Membrane
I6J88_RS22260	COG2885	chlorophyll binding
I6J88_RS22265	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6J88_RS22305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J88_RS22310	COG3201	nicotinamide mononucleotide transporter
I6J88_RS22315	COG1230	cation diffusion facilitator family transporter
I6J88_RS22325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J88_RS22335	COG2017	converts alpha-aldose to the beta-anomer
I6J88_RS22345	COG1085	galactose-1-phosphate uridylyltransferase
I6J88_RS22350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J88_RS22355	COG1119	ATPase activity
I6J88_RS22360	COG2005	Transcriptional regulator
I6J88_RS22360	COG3585	molybdate ion transport
I6J88_RS22370	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J88_RS22375	COG4149	molybdate abc transporter
I6J88_RS22380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J88_RS22385	COG0561	phosphatase activity
I6J88_RS22395	COG0583	DNA-binding transcription factor activity
I6J88_RS22400	COG2828	Protein conserved in bacteria
I6J88_RS22405	COG0471	metal ion transport
I6J88_RS22410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J88_RS22415	COG4677	pectinesterase activity
I6J88_RS22420	COG1881	PFAM PEBP family protein
I6J88_RS22430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J88_RS22440	COG0156	8-amino-7-oxononanoate synthase activity
I6J88_RS22445	COG2226	methyltransferase
I6J88_RS22450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J88_RS22460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J88_RS22470	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J88_RS22480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6J88_RS22485	COG0314	molybdopterin synthase activity
I6J88_RS22490	COG0670	Belongs to the BI1 family
I6J88_RS22495	COG0670	Belongs to the BI1 family
I6J88_RS22500	COG0392	lysyltransferase activity
I6J88_RS22505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J88_RS22510	COG3568	Endonuclease Exonuclease Phosphatase
I6J88_RS22520	COG0842	Transport permease protein
I6J88_RS22525	COG0842	Transport permease protein
I6J88_RS22530	COG1131	(ABC) transporter
I6J88_RS22540	COG1309	transcriptional regulator
I6J88_RS22545	COG0513	Belongs to the DEAD box helicase family
I6J88_RS22555	COG1199	ATP-dependent helicase activity
I6J88_RS22560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J88_RS22565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J88_RS22575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J88_RS22600	COG0668	transmembrane transport
I6J88_RS22605	COG1126	abc transporter atp-binding protein
I6J88_RS22610	COG0765	amino acid transport
I6J88_RS22615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS22625	COG5006	permease, DMT superfamily
I6J88_RS22635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J88_RS22640	COG2194	sulfuric ester hydrolase activity
I6J88_RS22650	COG1321	iron dependent repressor
I6J88_RS22655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J88_RS22660	COG1376	ErfK ybiS ycfS ynhG family protein
I6J88_RS22665	COG0488	(ABC) transporter
I6J88_RS22670	COG0561	phosphatase activity
I6J88_RS22675	COG1882	Formate acetyltransferase
I6J88_RS22680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J88_RS22685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J88_RS22690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J88_RS22695	COG0303	'Molybdopterin
I6J88_RS22700	COG1446	asparaginase
I6J88_RS22725	COG2200	EAL domain
I6J88_RS22745	COG2133	pyrroloquinoline quinone binding
I6J88_RS22750	COG0625	glutathione transferase activity
I6J88_RS22755	COG1686	Belongs to the peptidase S11 family
I6J88_RS22760	COG1349	DNA-binding transcription factor activity
I6J88_RS22765	COG0671	phosphoesterase, PA-phosphatase related
I6J88_RS22770	COG2814	Major facilitator Superfamily
I6J88_RS22780	COG0561	phosphatase activity
I6J88_RS22785	COG0738	Major facilitator superfamily
I6J88_RS22790	COG3226	Transcriptional regulator
I6J88_RS22805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J88_RS22815	COG0778	Nitroreductase
I6J88_RS22830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J88_RS22835	COG3842	ATPase activity
I6J88_RS22840	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J88_RS22845	COG1177	transmembrane transport
I6J88_RS22860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS22865	COG4160	amino acid transport
I6J88_RS22870	COG4215	(ABC) transporter
I6J88_RS22875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J88_RS22880	COG1126	abc transporter atp-binding protein
I6J88_RS22895	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J88_RS22900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J88_RS22905	COG0702	epimerase
I6J88_RS22910	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6J88_RS22915	COG0028	Belongs to the TPP enzyme family
I6J88_RS22920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J88_RS22925	COG1151	hydroxylamine reductase activity
I6J88_RS22930	COG2431	L-lysine efflux transmembrane transporter activity
I6J88_RS22940	COG3593	DNA synthesis involved in DNA repair
I6J88_RS22945	COG2990	Protein conserved in bacteria
I6J88_RS22950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J88_RS22960	COG1278	Cold shock
I6J88_RS23020	COG4220	transposase activity
I6J88_RS23035	COG0542	response to heat
I6J88_RS23055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J88_RS23060	COG4988	ABC transporter
I6J88_RS23065	COG0492	ferredoxin-NADP+ reductase activity
I6J88_RS23070	COG1522	sequence-specific DNA binding
I6J88_RS23075	COG1674	ftsk spoiiie
I6J88_RS23075	COG1178	ABC-type Fe3 transport system permease component
I6J88_RS23085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J88_RS23095	COG0243	molybdopterin cofactor binding
I6J88_RS23100	COG0437	4 iron, 4 sulfur cluster binding
I6J88_RS23105	COG3302	dmso reductase anchor subunit
I6J88_RS23110	COG1335	isochorismatase
I6J88_RS23120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J88_RS23125	COG1882	Formate acetyltransferase
I6J88_RS23130	COG2116	formate transmembrane transporter activity
I6J88_RS23135	COG1944	ATP diphosphatase activity
I6J88_RS23140	COG2323	membrane
I6J88_RS23155	COG0501	Belongs to the peptidase M48B family
I6J88_RS23165	COG0539	negative regulation of cytoplasmic translation
I6J88_RS23175	COG2333	competence protein COMEC
I6J88_RS23175	COG0658	competence protein
I6J88_RS23190	COG3214	Protein conserved in bacteria
I6J88_RS23205	COG3173	Aminoglycoside phosphotransferase
I6J88_RS23210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J88_RS23215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J88_RS23225	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6J88_RS23235	COG2989	Protein conserved in bacteria
I6J88_RS23240	COG3108	Peptidase M15
I6J88_RS23245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J88_RS23250	COG1448	Aminotransferase
I6J88_RS23270	COG0308	aminopeptidase N
I6J88_RS23280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J88_RS23290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J88_RS23295	COG0431	NADPH-dependent FMN reductase
I6J88_RS23310	COG3217	Mosc domain protein beta barrel domain protein
I6J88_RS23310	COG0633	Ferredoxin
I6J88_RS23315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J88_RS23315	COG0116	Belongs to the methyltransferase superfamily
I6J88_RS23320	COG0488	(ABC) transporter
I6J88_RS23325	COG2995	paraquat-inducible protein a
I6J88_RS23330	COG3008	intermembrane lipid transfer
I6J88_RS23330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J88_RS23335	COG3009	Protein conserved in bacteria
I6J88_RS23340	COG3130	regulation of translation
I6J88_RS23350	COG1067	ATP-dependent peptidase activity
I6J88_RS23360	COG2885	chlorophyll binding
I6J88_RS23360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J88_RS23370	COG3070	regulator of competence-specific genes
I6J88_RS23375	COG1289	transmembrane transporter activity
I6J88_RS23380	COG3304	Inner membrane component domain
I6J88_RS23385	COG0210	DNA helicase
I6J88_RS23400	COG1832	CoA-binding protein
I6J88_RS23420	COG2920	part of a sulfur-relay system
I6J88_RS23425	COG0670	Belongs to the BI1 family
I6J88_RS23435	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6J88_RS23440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J88_RS23445	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6J88_RS23450	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J88_RS23455	COG1999	signal sequence binding
I6J88_RS23460	COG1773	rubredoxin
I6J88_RS23465	COG1271	oxidase subunit
I6J88_RS23470	COG1294	oxidase, subunit
I6J88_RS23485	COG1278	Cold shock
I6J88_RS23490	COG1278	Cold shock
I6J88_RS23510	COG0348	domain, Protein
I6J88_RS23515	COG2205	protein histidine kinase activity
I6J88_RS23515	COG0784	Response regulator, receiver
I6J88_RS23515	COG2198	Histidine kinase
I6J88_RS23520	COG1879	ABC-type sugar transport system periplasmic component
I6J88_RS23525	COG0745	RESPONSE REGULATOR receiver
I6J88_RS23530	COG3005	denitrification pathway
I6J88_RS23535	COG0243	molybdopterin cofactor binding
I6J88_RS23540	COG3381	protein complex oligomerization
I6J88_RS23570	COG3729	General stress protein
I6J88_RS23575	COG2233	PERMEase
I6J88_RS23580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J88_RS23610	COG1309	transcriptional regulator
I6J88_RS23615	COG0506	proline dehydrogenase activity
I6J88_RS23615	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J88_RS23615	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J88_RS23625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J88_RS23645	COG1702	phosphate starvation-inducible protein PhoH
I6J88_RS23650	COG3658	cytochrome
I6J88_RS23655	COG1215	transferase activity, transferring glycosyl groups
I6J88_RS23660	COG0726	polysaccharide deacetylase
I6J88_RS23660	COG1649	PFAM Uncharacterised BCR, COG1649
I6J88_RS23665	COG0457	Tetratricopeptide repeat
I6J88_RS23670	COG3706	GGDEF domain
I6J88_RS23675	COG0582	viral genome integration into host DNA
I6J88_RS23700	COG4983	Phage plasmid primase, P4 family domain protein
I6J88_RS23725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J88_RS23735	COG2222	sugar isomerase
I6J88_RS23755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J88_RS23760	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS23770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J88_RS23795	COG1216	Glycosyl transferase, family 2
I6J88_RS23800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J88_RS23815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J88_RS23825	COG0204	Acyl-transferase
I6J88_RS23860	COG3210	domain, Protein
I6J88_RS23865	COG3210	domain, Protein
I6J88_RS23910	COG4644	lycopene metabolic process
I6J88_RS23915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J88_RS23945	COG2994	toxin metabolic process
I6J88_RS24000	COG3539	Fimbrial protein
I6J88_RS24045	COG4584	PFAM Integrase catalytic
I6J88_RS24050	COG1484	DNA-dependent DNA replication
I6J88_RS24060	COG4771	TonB-dependent receptor
I6J88_RS24065	COG2819	hydrolase of the alpha beta superfamily
I6J88_RS24070	COG2382	esterase
I6J88_RS24110	COG4771	TonB-dependent receptor
I6J88_RS24120	COG0523	cobalamin synthesis protein
I6J88_RS24165	COG3468	outer membrane autotransporter barrel domain protein
I6J88_RS24170	COG2020	methyltransferase activity
I6J88_RS24200	COG2003	Belongs to the UPF0758 family
I6J88_RS24255	COG3381	protein complex oligomerization
I6J88_RS24265	COG1462	curli production assembly transport component CsgG
I6J88_RS24280	COG2197	response regulator
I6J88_RS24305	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J88_RS24310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J88_RS24325	COG2943	transferase activity, transferring hexosyl groups
I6J88_RS24330	COG5645	(Lipo)protein
I6J88_RS24345	COG1560	Kdo2-lipid A biosynthetic process
I6J88_RS24355	COG2353	YceI-like domain
I6J88_RS24360	COG3038	cytochrome b561
I6J88_RS24370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J88_RS24395	COG2999	glutathione oxidoreductase activity
I6J88_RS24405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J88_RS24415	COG0673	inositol 2-dehydrogenase activity
I6J88_RS24420	COG0728	peptidoglycan biosynthetic process
I6J88_RS24425	COG3418	PFAM FlgN family protein
I6J88_RS24430	COG2747	anti-sigma28 factor FlgM
I6J88_RS24435	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6J88_RS24440	COG1815	bacterial-type flagellum-dependent cell motility
I6J88_RS24445	COG1558	bacterial-type flagellum-dependent cell motility
I6J88_RS24450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6J88_RS24455	COG1749	Flagellar hook protein flgE
I6J88_RS24460	COG4787	bacterial-type flagellum-dependent cell motility
I6J88_RS24465	COG4786	Flagellar basal body rod
I6J88_RS24480	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J88_RS24480	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6J88_RS24485	COG1256	bacterial-type flagellum assembly
I6J88_RS24490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J88_RS24495	COG1530	ribonuclease E activity
I6J88_RS24500	COG0564	pseudouridine synthase activity
I6J88_RS24510	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J88_RS24530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J88_RS24535	COG1028	Short-chain dehydrogenase reductase Sdr
I6J88_RS24545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J88_RS24550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J88_RS24555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J88_RS24565	COG0470	DNA polymerase III
I6J88_RS24570	COG0084	hydrolase, TatD family'
I6J88_RS24575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J88_RS24575	COG1263	PTS System
I6J88_RS24580	COG4773	Receptor
I6J88_RS24585	COG0537	adenosine 5'-monophosphoramidase activity
I6J88_RS24590	COG5633	Lipoprotein
I6J88_RS24595	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6J88_RS24615	COG1252	NADH dehydrogenase
I6J88_RS24620	COG3134	Outer membrane lipoprotein
I6J88_RS24625	COG1309	transcriptional regulator
I6J88_RS24635	COG1376	ErfK ybiS ycfS ynhG family protein
I6J88_RS24635	COG1388	LysM domain
I6J88_RS24640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J88_RS24645	COG4763	Acyl-transferase
I6J88_RS24650	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J88_RS24660	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J88_RS24670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J88_RS24675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J88_RS24685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J88_RS24690	COG1177	transmembrane transport
I6J88_RS24700	COG3842	ATPase activity
I6J88_RS24710	COG2850	peptidyl-arginine hydroxylation
I6J88_RS24715	COG2205	protein histidine kinase activity
I6J88_RS24725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J88_RS24745	COG1187	pseudouridine synthase activity
I6J88_RS24750	COG0538	isocitrate dehydrogenase activity
I6J88_RS24755	COG0582	viral genome integration into host DNA
I6J88_RS24960	COG3772	lysozyme
I6J88_RS24985	COG4220	transposase activity