locus-tag	class	description
I6J92_RS00005	COG2223	nitrite transmembrane transporter activity
I6J92_RS00010	COG3056	Lipoprotein
I6J92_RS00015	COG0271	Belongs to the BolA IbaG family
I6J92_RS00035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J92_RS00040	COG0776	regulation of translation
I6J92_RS00045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J92_RS00050	COG1555	photosystem II stabilization
I6J92_RS00055	COG0824	Thioesterase
I6J92_RS00065	COG4533	DNA binding
I6J92_RS00075	COG1522	sequence-specific DNA binding
I6J92_RS00080	COG1132	(ABC) transporter
I6J92_RS00085	COG1132	(ABC) transporter
I6J92_RS00090	COG0347	Belongs to the P(II) protein family
I6J92_RS00095	COG0004	ammonium transporteR
I6J92_RS00100	COG1946	Acyl-CoA thioesterase
I6J92_RS00105	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6J92_RS00110	COG3695	enzyme binding
I6J92_RS00120	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6J92_RS00125	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6J92_RS00135	COG0110	maltose O-acetyltransferase activity
I6J92_RS00150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J92_RS00155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS00160	COG1309	transcriptional regulator
I6J92_RS00165	COG3264	Mechanosensitive ion channel
I6J92_RS00165	COG1196	nuclear chromosome segregation
I6J92_RS00175	COG3923	Primosomal replication protein n
I6J92_RS00180	COG2832	Protein of unknown function (DUF454)
I6J92_RS00190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J92_RS00225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS00230	COG4651	solute:proton antiporter activity
I6J92_RS00230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J92_RS00235	COG2223	nitrite transmembrane transporter activity
I6J92_RS00240	COG0737	Belongs to the 5'-nucleotidase family
I6J92_RS00245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J92_RS00250	COG3735	TraB family
I6J92_RS00255	COG2217	Heavy metal translocating P-type atpase
I6J92_RS00260	COG2066	Belongs to the glutaminase family
I6J92_RS00265	COG0531	amino acid
I6J92_RS00270	COG0789	Transcriptional regulator
I6J92_RS00295	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J92_RS00300	COG0330	HflC and HflK could
I6J92_RS00305	COG4619	ABC transporter
I6J92_RS00310	COG0390	transport system, permease component
I6J92_RS00315	COG3118	belongs to the thioredoxin family
I6J92_RS00320	COG0300	oxidoreductase activity
I6J92_RS00325	COG2755	lipolytic protein G-D-S-L family
I6J92_RS00330	COG4181	ATPase activity
I6J92_RS00335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J92_RS00355	COG1414	Transcriptional regulator
I6J92_RS00360	COG3960	tartronate-semialdehyde synthase activity
I6J92_RS00365	COG3622	Belongs to the hyi family
I6J92_RS00370	COG2084	Dehydrogenase
I6J92_RS00375	COG1953	Uracil, thiamine, allantoin
I6J92_RS00385	COG2233	PERMEase
I6J92_RS00390	COG1929	Belongs to the glycerate kinase type-1 family
I6J92_RS00395	COG3257	ureidoglycine aminohydrolase activity
I6J92_RS00400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J92_RS00405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J92_RS00410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J92_RS00415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J92_RS00425	COG0549	Belongs to the carbamate kinase family
I6J92_RS00430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J92_RS00435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J92_RS00450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J92_RS00460	COG1988	membrane-bound metal-dependent
I6J92_RS00465	COG2501	S4 domain
I6J92_RS00495	COG0500	methyltransferase
I6J92_RS00500	COG4571	Outer membrane protease
I6J92_RS00510	COG4783	chaperone-mediated protein folding
I6J92_RS00515	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS00520	COG5002	protein histidine kinase activity
I6J92_RS00525	COG0745	RESPONSE REGULATOR receiver
I6J92_RS00530	COG1538	Outer membrane efflux protein
I6J92_RS00535	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS00540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS00545	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J92_RS00550	COG1113	amino acid transport
I6J92_RS00555	COG0668	transmembrane transport
I6J92_RS00560	COG0778	Nitroreductase
I6J92_RS00565	COG2315	Protein conserved in bacteria
I6J92_RS00585	COG2977	Belongs to the P-Pant transferase superfamily
I6J92_RS00590	COG4771	TonB-dependent receptor
I6J92_RS00600	COG2382	esterase
I6J92_RS00605	COG3251	PFAM MbtH domain protein
I6J92_RS00610	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6J92_RS00610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J92_RS00615	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J92_RS00620	COG1120	ATPase activity
I6J92_RS00625	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS00630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS00640	COG4592	Periplasmic binding protein
I6J92_RS00645	COG1169	isochorismate synthase
I6J92_RS00650	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J92_RS00655	COG1535	isochorismatase
I6J92_RS00655	COG3433	isochorismatase activity
I6J92_RS00660	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS00665	COG2050	protein possibly involved in aromatic compounds catabolism
I6J92_RS00670	COG1966	Carbon starvation protein
I6J92_RS00675	COG2879	small protein
I6J92_RS00680	COG0371	Dehydrogenase
I6J92_RS00685	COG0436	Aminotransferase
I6J92_RS00690	COG1475	DNA binding
I6J92_RS00695	COG3969	phosphoadenosine phosphosulfate
I6J92_RS00700	COG0583	DNA-binding transcription factor activity
I6J92_RS00705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J92_RS00710	COG0450	alkyl hydroperoxide reductase
I6J92_RS00715	COG3634	alkyl hydroperoxide reductase activity
I6J92_RS00720	COG0589	response to stress
I6J92_RS00725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J92_RS00730	COG3719	Belongs to the RNase T2 family
I6J92_RS00735	COG0471	metal ion transport
I6J92_RS00750	COG3051	citrate lyase alpha subunit
I6J92_RS00755	COG2301	Belongs to the HpcH HpaI aldolase family
I6J92_RS00765	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6J92_RS00770	COG3290	protein histidine kinase activity
I6J92_RS00775	COG4565	transcriptional regulatory protein
I6J92_RS00780	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J92_RS00800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J92_RS00805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J92_RS00830	COG1686	Belongs to the peptidase S11 family
I6J92_RS00835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J92_RS00840	COG0772	Belongs to the SEDS family
I6J92_RS00845	COG0768	penicillin binding
I6J92_RS00855	COG0799	negative regulation of ribosome biogenesis
I6J92_RS00860	COG0406	alpha-ribazole phosphatase activity
I6J92_RS00870	COG1466	dna polymerase III delta subunit
I6J92_RS00885	COG2888	peptidyl-tyrosine sulfation
I6J92_RS00895	COG1126	abc transporter atp-binding protein
I6J92_RS00900	COG0765	amino acid transport
I6J92_RS00905	COG0765	amino acid transport
I6J92_RS00910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS00920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6J92_RS00925	COG4535	Mg2 and Co2 transporter CorC
I6J92_RS00935	COG1702	phosphate starvation-inducible protein PhoH
I6J92_RS00945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J92_RS00985	COG0367	asparagine synthase
I6J92_RS00990	COG0647	UMP catabolic process
I6J92_RS00995	COG1940	carbohydrate kinase activity
I6J92_RS00995	COG1846	Transcriptional regulator
I6J92_RS01000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J92_RS01010	COG1263	PTS System
I6J92_RS01010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS01010	COG2190	(PTS) system
I6J92_RS01030	COG0861	Integral membrane protein TerC family
I6J92_RS01035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J92_RS01040	COG1454	alcohol dehydrogenase
I6J92_RS01045	COG3395	kinase activity
I6J92_RS01050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J92_RS01055	COG1349	DNA-binding transcription factor activity
I6J92_RS01075	COG0735	belongs to the Fur family
I6J92_RS01085	COG0716	FMN binding
I6J92_RS01095	COG0596	Alpha beta hydrolase
I6J92_RS01100	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6J92_RS01105	COG0033	Phosphoglucomutase
I6J92_RS01110	COG0531	amino acid
I6J92_RS01115	COG1982	Orn Lys Arg decarboxylase major
I6J92_RS01125	COG0745	RESPONSE REGULATOR receiver
I6J92_RS01130	COG2205	protein histidine kinase activity
I6J92_RS01160	COG3272	Protein of unknown function (DUF1722)
I6J92_RS01165	COG0415	Belongs to the DNA photolyase family
I6J92_RS01175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J92_RS01180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J92_RS01185	COG1984	allophanate hydrolase subunit 2
I6J92_RS01190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J92_RS01200	COG3180	Ammonia monooxygenase
I6J92_RS01210	COG0372	Belongs to the citrate synthase family
I6J92_RS01220	COG2009	succinate dehydrogenase
I6J92_RS01225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J92_RS01230	COG1053	succinate dehydrogenase
I6J92_RS01235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J92_RS01240	COG0567	Dehydrogenase, E1 component
I6J92_RS01245	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J92_RS01255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J92_RS01265	COG1271	oxidase subunit
I6J92_RS01270	COG1294	oxidase, subunit
I6J92_RS01275	COG4890	Cyd operon protein YbgT
I6J92_RS01280	COG3790	cyd operon protein YbgE
I6J92_RS01285	COG0824	Thioesterase
I6J92_RS01290	COG0811	peptide transport
I6J92_RS01295	COG0848	biopolymer transport protein
I6J92_RS01300	COG3064	Membrane
I6J92_RS01310	COG2885	chlorophyll binding
I6J92_RS01315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6J92_RS01350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J92_RS01355	COG3201	nicotinamide mononucleotide transporter
I6J92_RS01360	COG1230	cation diffusion facilitator family transporter
I6J92_RS01370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J92_RS01380	COG2017	converts alpha-aldose to the beta-anomer
I6J92_RS01390	COG1085	galactose-1-phosphate uridylyltransferase
I6J92_RS01395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J92_RS01400	COG1119	ATPase activity
I6J92_RS01405	COG2005	Transcriptional regulator
I6J92_RS01405	COG3585	molybdate ion transport
I6J92_RS01415	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J92_RS01420	COG4149	molybdate abc transporter
I6J92_RS01425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J92_RS01430	COG0561	phosphatase activity
I6J92_RS01440	COG0583	DNA-binding transcription factor activity
I6J92_RS01445	COG2828	Protein conserved in bacteria
I6J92_RS01450	COG0471	metal ion transport
I6J92_RS01455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J92_RS01460	COG4677	pectinesterase activity
I6J92_RS01465	COG1881	PFAM PEBP family protein
I6J92_RS01475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J92_RS01485	COG0156	8-amino-7-oxononanoate synthase activity
I6J92_RS01490	COG2226	methyltransferase
I6J92_RS01495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J92_RS01505	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J92_RS01515	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J92_RS01525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6J92_RS01530	COG0314	molybdopterin synthase activity
I6J92_RS01535	COG0670	Belongs to the BI1 family
I6J92_RS01540	COG0670	Belongs to the BI1 family
I6J92_RS01550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J92_RS01555	COG3568	Endonuclease Exonuclease Phosphatase
I6J92_RS01565	COG0842	Transport permease protein
I6J92_RS01570	COG0842	Transport permease protein
I6J92_RS01575	COG1131	(ABC) transporter
I6J92_RS01585	COG1309	transcriptional regulator
I6J92_RS01590	COG0513	Belongs to the DEAD box helicase family
I6J92_RS01600	COG1199	ATP-dependent helicase activity
I6J92_RS01605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J92_RS01610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J92_RS01620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J92_RS01645	COG0668	transmembrane transport
I6J92_RS01650	COG1126	abc transporter atp-binding protein
I6J92_RS01655	COG0765	amino acid transport
I6J92_RS01660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS01670	COG5006	permease, DMT superfamily
I6J92_RS01680	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J92_RS01685	COG2194	sulfuric ester hydrolase activity
I6J92_RS01695	COG1321	iron dependent repressor
I6J92_RS01700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J92_RS01705	COG1376	ErfK ybiS ycfS ynhG family protein
I6J92_RS01710	COG0488	(ABC) transporter
I6J92_RS01715	COG0561	phosphatase activity
I6J92_RS01720	COG1882	Formate acetyltransferase
I6J92_RS01725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J92_RS01730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J92_RS01735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J92_RS01740	COG0303	'Molybdopterin
I6J92_RS01745	COG1446	asparaginase
I6J92_RS01770	COG2200	EAL domain
I6J92_RS01775	COG2199	diguanylate cyclase activity
I6J92_RS01790	COG2133	pyrroloquinoline quinone binding
I6J92_RS01795	COG0625	glutathione transferase activity
I6J92_RS01800	COG1686	Belongs to the peptidase S11 family
I6J92_RS01805	COG1349	DNA-binding transcription factor activity
I6J92_RS01810	COG0671	phosphoesterase, PA-phosphatase related
I6J92_RS01815	COG2814	Major facilitator Superfamily
I6J92_RS01825	COG0561	phosphatase activity
I6J92_RS01830	COG0738	Major facilitator superfamily
I6J92_RS01835	COG3226	Transcriptional regulator
I6J92_RS01850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J92_RS01860	COG0778	Nitroreductase
I6J92_RS01875	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J92_RS01880	COG3842	ATPase activity
I6J92_RS01885	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J92_RS01890	COG1177	transmembrane transport
I6J92_RS01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS01910	COG4160	amino acid transport
I6J92_RS01915	COG4215	(ABC) transporter
I6J92_RS01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS01925	COG1126	abc transporter atp-binding protein
I6J92_RS01940	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J92_RS01945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J92_RS01950	COG0702	epimerase
I6J92_RS01955	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6J92_RS01960	COG0028	Belongs to the TPP enzyme family
I6J92_RS01965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J92_RS01970	COG1151	hydroxylamine reductase activity
I6J92_RS01975	COG2431	L-lysine efflux transmembrane transporter activity
I6J92_RS01985	COG3593	DNA synthesis involved in DNA repair
I6J92_RS01990	COG2990	Protein conserved in bacteria
I6J92_RS01995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS02005	COG1278	Cold shock
I6J92_RS02015	COG0542	response to heat
I6J92_RS02035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J92_RS02040	COG4988	ABC transporter
I6J92_RS02045	COG0492	ferredoxin-NADP+ reductase activity
I6J92_RS02050	COG1522	sequence-specific DNA binding
I6J92_RS02055	COG1674	ftsk spoiiie
I6J92_RS02055	COG1178	ABC-type Fe3 transport system permease component
I6J92_RS02065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J92_RS02075	COG0243	molybdopterin cofactor binding
I6J92_RS02080	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS02085	COG3302	dmso reductase anchor subunit
I6J92_RS02090	COG1335	isochorismatase
I6J92_RS02100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J92_RS02105	COG1882	Formate acetyltransferase
I6J92_RS02110	COG2116	formate transmembrane transporter activity
I6J92_RS02115	COG1944	ATP diphosphatase activity
I6J92_RS02120	COG2323	membrane
I6J92_RS02135	COG0501	Belongs to the peptidase M48B family
I6J92_RS02145	COG0539	negative regulation of cytoplasmic translation
I6J92_RS02155	COG2333	competence protein COMEC
I6J92_RS02155	COG0658	competence protein
I6J92_RS02170	COG3214	Protein conserved in bacteria
I6J92_RS02185	COG3173	Aminoglycoside phosphotransferase
I6J92_RS02190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J92_RS02195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J92_RS02205	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6J92_RS02215	COG2989	Protein conserved in bacteria
I6J92_RS02220	COG3108	Peptidase M15
I6J92_RS02225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J92_RS02230	COG1448	Aminotransferase
I6J92_RS02250	COG0308	aminopeptidase N
I6J92_RS02260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J92_RS02270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J92_RS02275	COG0431	NADPH-dependent FMN reductase
I6J92_RS02290	COG0633	Ferredoxin
I6J92_RS02290	COG3217	Mosc domain protein beta barrel domain protein
I6J92_RS02295	COG0116	Belongs to the methyltransferase superfamily
I6J92_RS02295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J92_RS02300	COG0488	(ABC) transporter
I6J92_RS02305	COG2995	paraquat-inducible protein a
I6J92_RS02310	COG3008	intermembrane lipid transfer
I6J92_RS02310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J92_RS02315	COG3009	Protein conserved in bacteria
I6J92_RS02320	COG3130	regulation of translation
I6J92_RS02330	COG1067	ATP-dependent peptidase activity
I6J92_RS02340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J92_RS02340	COG2885	chlorophyll binding
I6J92_RS02350	COG3070	regulator of competence-specific genes
I6J92_RS02355	COG1289	transmembrane transporter activity
I6J92_RS02360	COG3304	Inner membrane component domain
I6J92_RS02365	COG0210	DNA helicase
I6J92_RS02380	COG1832	CoA-binding protein
I6J92_RS02400	COG2920	part of a sulfur-relay system
I6J92_RS02405	COG0670	Belongs to the BI1 family
I6J92_RS02415	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6J92_RS02420	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J92_RS02425	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6J92_RS02430	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J92_RS02435	COG1999	signal sequence binding
I6J92_RS02440	COG1773	rubredoxin
I6J92_RS02445	COG1271	oxidase subunit
I6J92_RS02450	COG1294	oxidase, subunit
I6J92_RS02465	COG1278	Cold shock
I6J92_RS02470	COG1278	Cold shock
I6J92_RS02490	COG0348	domain, Protein
I6J92_RS02495	COG0784	Response regulator, receiver
I6J92_RS02495	COG2205	protein histidine kinase activity
I6J92_RS02495	COG2198	Histidine kinase
I6J92_RS02500	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS02505	COG0745	RESPONSE REGULATOR receiver
I6J92_RS02510	COG3005	denitrification pathway
I6J92_RS02515	COG0243	molybdopterin cofactor binding
I6J92_RS02520	COG3381	protein complex oligomerization
I6J92_RS02550	COG3729	General stress protein
I6J92_RS02555	COG2233	PERMEase
I6J92_RS02560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J92_RS02590	COG1309	transcriptional regulator
I6J92_RS02595	COG0506	proline dehydrogenase activity
I6J92_RS02595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J92_RS02595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J92_RS02605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J92_RS02625	COG1702	phosphate starvation-inducible protein PhoH
I6J92_RS02630	COG3658	cytochrome
I6J92_RS02635	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS02640	COG1649	PFAM Uncharacterised BCR, COG1649
I6J92_RS02640	COG0726	polysaccharide deacetylase
I6J92_RS02645	COG0457	Tetratricopeptide repeat
I6J92_RS02650	COG3706	GGDEF domain
I6J92_RS02655	COG0582	viral genome integration into host DNA
I6J92_RS02680	COG4983	Phage plasmid primase, P4 family domain protein
I6J92_RS02705	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J92_RS02715	COG2222	sugar isomerase
I6J92_RS02735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J92_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS02750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J92_RS02775	COG1216	Glycosyl transferase, family 2
I6J92_RS02780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J92_RS02795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J92_RS02805	COG0204	Acyl-transferase
I6J92_RS02840	COG3210	domain, Protein
I6J92_RS02845	COG3210	domain, Protein
I6J92_RS02890	COG4644	lycopene metabolic process
I6J92_RS02895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J92_RS02925	COG2994	toxin metabolic process
I6J92_RS02980	COG3539	Fimbrial protein
I6J92_RS03020	COG3335	DDE superfamily endonuclease
I6J92_RS03025	COG4771	TonB-dependent receptor
I6J92_RS03030	COG2819	hydrolase of the alpha beta superfamily
I6J92_RS03035	COG2382	esterase
I6J92_RS03080	COG4771	TonB-dependent receptor
I6J92_RS03090	COG0523	cobalamin synthesis protein
I6J92_RS03135	COG3468	outer membrane autotransporter barrel domain protein
I6J92_RS03140	COG2020	methyltransferase activity
I6J92_RS03170	COG2003	Belongs to the UPF0758 family
I6J92_RS03225	COG3381	protein complex oligomerization
I6J92_RS03235	COG1462	curli production assembly transport component CsgG
I6J92_RS03250	COG2197	response regulator
I6J92_RS03275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J92_RS03280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J92_RS03295	COG2943	transferase activity, transferring hexosyl groups
I6J92_RS03300	COG5645	(Lipo)protein
I6J92_RS03315	COG1560	Kdo2-lipid A biosynthetic process
I6J92_RS03325	COG2353	YceI-like domain
I6J92_RS03330	COG3038	cytochrome b561
I6J92_RS03340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J92_RS03365	COG2999	glutathione oxidoreductase activity
I6J92_RS03375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J92_RS03385	COG0673	inositol 2-dehydrogenase activity
I6J92_RS03390	COG0728	peptidoglycan biosynthetic process
I6J92_RS03395	COG3418	PFAM FlgN family protein
I6J92_RS03400	COG2747	anti-sigma28 factor FlgM
I6J92_RS03405	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6J92_RS03410	COG1815	bacterial-type flagellum-dependent cell motility
I6J92_RS03415	COG1558	bacterial-type flagellum-dependent cell motility
I6J92_RS03420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6J92_RS03425	COG1749	Flagellar hook protein flgE
I6J92_RS03430	COG4787	bacterial-type flagellum-dependent cell motility
I6J92_RS03435	COG4786	Flagellar basal body rod
I6J92_RS03450	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6J92_RS03450	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J92_RS03455	COG1256	bacterial-type flagellum assembly
I6J92_RS03460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J92_RS03465	COG1530	ribonuclease E activity
I6J92_RS03470	COG0564	pseudouridine synthase activity
I6J92_RS03475	COG0424	maF-like protein
I6J92_RS03480	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J92_RS03500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J92_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS03515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J92_RS03520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J92_RS03525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J92_RS03535	COG0470	DNA polymerase III
I6J92_RS03540	COG0084	hydrolase, TatD family'
I6J92_RS03545	COG1263	PTS System
I6J92_RS03545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS03550	COG4773	Receptor
I6J92_RS03555	COG0537	adenosine 5'-monophosphoramidase activity
I6J92_RS03560	COG5633	Lipoprotein
I6J92_RS03565	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6J92_RS03585	COG1252	NADH dehydrogenase
I6J92_RS03590	COG3134	Outer membrane lipoprotein
I6J92_RS03595	COG1309	transcriptional regulator
I6J92_RS03605	COG1388	LysM domain
I6J92_RS03605	COG1376	ErfK ybiS ycfS ynhG family protein
I6J92_RS03610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J92_RS03615	COG4763	Acyl-transferase
I6J92_RS03620	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J92_RS03630	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J92_RS03640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J92_RS03645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J92_RS03655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J92_RS03660	COG1177	transmembrane transport
I6J92_RS03670	COG3842	ATPase activity
I6J92_RS03680	COG2850	peptidyl-arginine hydroxylation
I6J92_RS03685	COG2205	protein histidine kinase activity
I6J92_RS03695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J92_RS03715	COG1187	pseudouridine synthase activity
I6J92_RS03720	COG0538	isocitrate dehydrogenase activity
I6J92_RS03725	COG0582	viral genome integration into host DNA
I6J92_RS03815	COG2076	Multidrug Resistance protein
I6J92_RS03825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J92_RS03880	COG3772	lysozyme
I6J92_RS03895	COG4220	transposase activity
I6J92_RS03915	COG1030	water channel activity
I6J92_RS03965	COG1196	nuclear chromosome segregation
I6J92_RS04000	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6J92_RS04025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J92_RS04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J92_RS04035	COG1121	(ABC) transporter
I6J92_RS04045	COG0538	isocitrate dehydrogenase activity
I6J92_RS04055	COG5562	phage envelope protein
I6J92_RS04060	COG0789	Transcriptional regulator
I6J92_RS04065	COG2200	EAL domain
I6J92_RS04145	COG2894	cell division
I6J92_RS04170	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J92_RS04185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J92_RS04190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J92_RS04210	COG2719	SpoVR family
I6J92_RS04220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J92_RS04230	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J92_RS04240	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6J92_RS04255	COG0157	Belongs to the NadC ModD family
I6J92_RS04260	COG0500	methyltransferase
I6J92_RS04265	COG1120	ATPase activity
I6J92_RS04270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS04275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J92_RS04285	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J92_RS04285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS04285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J92_RS04290	COG1461	Dihydroxyacetone kinase
I6J92_RS04295	COG2376	Dihydroxyacetone kinase
I6J92_RS04300	COG3284	Transcriptional regulator
I6J92_RS04310	COG0012	GTP binding
I6J92_RS04325	COG0659	secondary active sulfate transmembrane transporter activity
I6J92_RS04330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J92_RS04355	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J92_RS04360	COG3094	Invasion gene expression up-regulator, SirB
I6J92_RS04365	COG2912	Transglutaminase-like superfamily
I6J92_RS04380	COG0387	Pfam Sodium calcium exchanger
I6J92_RS04385	COG4572	Cation transport regulator
I6J92_RS04390	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6J92_RS04395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6J92_RS04400	COG4932	domain protein
I6J92_RS04405	COG2197	response regulator
I6J92_RS04410	COG3850	Histidine kinase
I6J92_RS04415	COG2223	nitrite transmembrane transporter activity
I6J92_RS04420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J92_RS04425	COG1140	nitrate reductase beta subunit
I6J92_RS04430	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J92_RS04435	COG2181	nitrate reductase activity
I6J92_RS04460	COG0788	formyltetrahydrofolate deformylase activity
I6J92_RS04470	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J92_RS04475	COG0745	RESPONSE REGULATOR receiver
I6J92_RS04480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J92_RS04490	COG1435	thymidine kinase activity
I6J92_RS04500	COG1454	alcohol dehydrogenase
I6J92_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS04505	COG2095	MarC family integral membrane protein
I6J92_RS04515	COG4166	transmembrane transport
I6J92_RS04520	COG0601	transmembrane transport
I6J92_RS04525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J92_RS04530	COG0444	Belongs to the ABC transporter superfamily
I6J92_RS04535	COG4608	Belongs to the ABC transporter superfamily
I6J92_RS04555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J92_RS04560	COG2350	Protein conserved in bacteria
I6J92_RS04570	COG1607	acyl-coa hydrolase
I6J92_RS04590	COG3047	cAMP biosynthetic process
I6J92_RS04595	COG3685	Protein conserved in bacteria
I6J92_RS04600	COG3685	Protein conserved in bacteria
I6J92_RS04615	COG0135	phosphoribosylanthranilate isomerase activity
I6J92_RS04615	COG0134	indole-3-glycerol-phosphate synthase activity
I6J92_RS04620	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J92_RS04620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J92_RS04625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J92_RS04635	COG0613	PHP domain protein
I6J92_RS04640	COG0009	L-threonylcarbamoyladenylate synthase
I6J92_RS04645	COG4907	membrane protein (DUF2207)
I6J92_RS04650	COG1187	pseudouridine synthase activity
I6J92_RS04655	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6J92_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS04665	COG0616	signal peptide processing
I6J92_RS04675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J92_RS04680	COG0583	DNA-binding transcription factor activity
I6J92_RS04700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J92_RS04710	COG0671	phosphoesterase, PA-phosphatase related
I6J92_RS04715	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6J92_RS04720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6J92_RS04730	COG0023	Translation Initiation Factor
I6J92_RS04740	COG1349	DNA-binding transcription factor activity
I6J92_RS04750	COG5001	Diguanylate cyclase
I6J92_RS04765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J92_RS04765	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J92_RS04770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J92_RS04780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS04785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J92_RS04795	COG2814	Major facilitator Superfamily
I6J92_RS04800	COG4172	Belongs to the ABC transporter superfamily
I6J92_RS04805	COG4172	Belongs to the ABC transporter superfamily
I6J92_RS04810	COG4171	peptide transport system, permease
I6J92_RS04815	COG4168	peptide transport system, permease
I6J92_RS04820	COG4166	transmembrane transport
I6J92_RS04835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6J92_RS04840	COG1842	Phage shock protein A
I6J92_RS04850	COG1983	PspC domain protein
I6J92_RS04860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J92_RS04865	COG0366	Alpha amylase catalytic
I6J92_RS04870	COG1653	transport
I6J92_RS04875	COG1175	transmembrane transport
I6J92_RS04885	COG1063	alcohol dehydrogenase
I6J92_RS04890	COG1082	Xylose isomerase domain protein TIM barrel
I6J92_RS04895	COG0673	inositol 2-dehydrogenase activity
I6J92_RS04900	COG1554	hydrolase, family 65, central catalytic
I6J92_RS04905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J92_RS04920	COG1609	Transcriptional regulator
I6J92_RS04925	COG3106	COG3106 Predicted ATPase
I6J92_RS04935	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6J92_RS04940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J92_RS04945	COG4948	Mandelate Racemase Muconate Lactonizing
I6J92_RS04950	COG2866	Carboxypeptidase
I6J92_RS04955	COG0702	epimerase
I6J92_RS04960	COG1073	alpha beta
I6J92_RS04965	COG0583	DNA-binding transcription factor activity
I6J92_RS04970	COG4166	transmembrane transport
I6J92_RS04975	COG0668	transmembrane transport
I6J92_RS04980	COG3182	Iron-regulated membrane protein
I6J92_RS04985	COG0589	response to stress
I6J92_RS04990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J92_RS04995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J92_RS05005	COG2207	Transcriptional regulator
I6J92_RS05020	COG2840	Smr protein MutS2
I6J92_RS05025	COG3706	GGDEF domain
I6J92_RS05035	COG0513	Belongs to the DEAD box helicase family
I6J92_RS05060	COG0589	response to stress
I6J92_RS05065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J92_RS05070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J92_RS05070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J92_RS05070	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J92_RS05070	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J92_RS05075	COG3042	response to heat
I6J92_RS05080	COG3187	Heat shock protein
I6J92_RS05085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J92_RS05090	COG2911	Protein conserved in bacteria
I6J92_RS05100	COG3784	Protein of unknown function (DUF1318)
I6J92_RS05110	COG0667	Aldo Keto reductase
I6J92_RS05115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J92_RS05120	COG4589	Belongs to the CDS family
I6J92_RS05125	COG2267	carboxylic ester hydrolase activity
I6J92_RS05130	COG0671	phosphoesterase, PA-phosphatase related
I6J92_RS05130	COG2453	phosphatase
I6J92_RS05140	COG1643	Atp-dependent helicase
I6J92_RS05145	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6J92_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS05155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J92_RS05160	COG3038	cytochrome b561
I6J92_RS05180	COG0583	DNA-binding transcription factor activity
I6J92_RS05185	COG5383	Protein conserved in bacteria
I6J92_RS05195	COG2841	Protein conserved in bacteria
I6J92_RS05200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J92_RS05205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J92_RS05210	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6J92_RS05215	COG0500	methyltransferase
I6J92_RS05225	COG3135	benzoate transporter
I6J92_RS05230	COG1396	sequence-specific DNA binding
I6J92_RS05235	COG0826	peptidase U32
I6J92_RS05250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J92_RS05255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J92_RS05260	COG3842	ATPase activity
I6J92_RS05265	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J92_RS05270	COG1177	transmembrane transport
I6J92_RS05295	COG3238	Protein conserved in bacteria
I6J92_RS05300	COG1247	-acetyltransferase
I6J92_RS05310	COG4772	TonB-dependent receptor
I6J92_RS05320	COG1113	amino acid transport
I6J92_RS05325	COG0625	glutathione transferase activity
I6J92_RS05330	COG0625	glutathione transferase activity
I6J92_RS05340	COG3501	Rhs element vgr protein
I6J92_RS05350	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J92_RS05355	COG0384	phenazine biosynthesis protein PhzF
I6J92_RS05360	COG2181	nitrate reductase activity
I6J92_RS05365	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J92_RS05370	COG1140	nitrate reductase beta subunit
I6J92_RS05375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6J92_RS05380	COG2223	nitrite transmembrane transporter activity
I6J92_RS05385	COG0697	spore germination
I6J92_RS05395	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS05400	COG2864	formate dehydrogenase
I6J92_RS05405	COG3093	addiction module antidote protein HigA
I6J92_RS05415	COG1064	alcohol dehydrogenase
I6J92_RS05435	COG1764	response to oxidative stress
I6J92_RS05440	COG2199	diguanylate cyclase activity
I6J92_RS05440	COG2202	Pas domain
I6J92_RS05440	COG2200	EAL domain
I6J92_RS05450	COG1649	PFAM Uncharacterised BCR, COG1649
I6J92_RS05455	COG0531	amino acid
I6J92_RS05475	COG0641	radical SAM
I6J92_RS05480	COG3119	arylsulfatase activity
I6J92_RS05485	COG2207	Transcriptional regulator
I6J92_RS05495	COG0243	molybdopterin cofactor binding
I6J92_RS05500	COG3539	Fimbrial protein
I6J92_RS05505	COG3539	Fimbrial protein
I6J92_RS05510	COG3539	Fimbrial protein
I6J92_RS05605	COG4128	Pfam Zonular occludens toxin
I6J92_RS05660	COG3550	peptidyl-serine autophosphorylation
I6J92_RS05665	COG1396	sequence-specific DNA binding
I6J92_RS05675	COG3781	membrane
I6J92_RS05685	COG2199	diguanylate cyclase activity
I6J92_RS05695	COG2066	Belongs to the glutaminase family
I6J92_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS05705	COG0583	DNA-binding transcription factor activity
I6J92_RS05725	COG1846	Transcriptional regulator
I6J92_RS05730	COG4977	sequence-specific DNA binding
I6J92_RS05740	COG2723	6-phospho-beta-galactosidase activity
I6J92_RS05750	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J92_RS05755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J92_RS05765	COG2188	Transcriptional regulator
I6J92_RS05770	COG0697	spore germination
I6J92_RS05775	COG2814	Major facilitator Superfamily
I6J92_RS05785	COG3706	GGDEF domain
I6J92_RS05790	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J92_RS05795	COG0339	signal peptide processing
I6J92_RS05800	COG4221	oxidoreductase activity
I6J92_RS05805	COG1802	Transcriptional regulator
I6J92_RS05815	COG0246	Mannitol dehydrogenase
I6J92_RS05820	COG0477	Major facilitator Superfamily
I6J92_RS05825	COG1063	alcohol dehydrogenase
I6J92_RS05830	COG4948	Mandelate Racemase Muconate Lactonizing
I6J92_RS05845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J92_RS05865	COG0243	molybdopterin cofactor binding
I6J92_RS05870	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS05875	COG3302	dmso reductase anchor subunit
I6J92_RS05880	COG3381	protein complex oligomerization
I6J92_RS05890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J92_RS05895	COG1940	carbohydrate kinase activity
I6J92_RS05900	COG0583	DNA-binding transcription factor activity
I6J92_RS05905	COG2814	Major facilitator Superfamily
I6J92_RS05920	COG3591	Belongs to the peptidase S1B family
I6J92_RS05935	COG0628	permease
I6J92_RS05940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6J92_RS05945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J92_RS05955	COG0531	amino acid
I6J92_RS05965	COG3136	membrane protein required for alginate biosynthesis
I6J92_RS05970	COG0745	RESPONSE REGULATOR receiver
I6J92_RS05975	COG2205	protein histidine kinase activity
I6J92_RS05985	COG0114	fumarate hydratase activity
I6J92_RS05990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J92_RS05990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J92_RS05995	COG1482	cell wall glycoprotein biosynthetic process
I6J92_RS06000	COG5339	Protein conserved in bacteria
I6J92_RS06015	COG3250	beta-galactosidase activity
I6J92_RS06020	COG1309	transcriptional regulator
I6J92_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS06030	COG1609	Transcriptional regulator
I6J92_RS06035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS06035	COG1263	PTS System
I6J92_RS06040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J92_RS06050	COG0673	inositol 2-dehydrogenase activity
I6J92_RS06090	COG4659	FMN binding
I6J92_RS06095	COG4660	Part of a membrane complex involved in electron transport
I6J92_RS06100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J92_RS06105	COG3104	oligopeptide transport
I6J92_RS06110	COG0625	glutathione transferase activity
I6J92_RS06130	COG3895	Periplasmic Protein
I6J92_RS06140	COG3133	Outer membrane lipoprotein
I6J92_RS06155	COG1566	PFAM secretion protein HlyD family protein
I6J92_RS06160	COG1289	transmembrane transporter activity
I6J92_RS06165	COG2032	superoxide dismutase activity
I6J92_RS06170	COG4989	oxidoreductase activity
I6J92_RS06175	COG3313	Fe-S protein
I6J92_RS06180	COG1309	transcriptional regulator
I6J92_RS06185	COG1902	pentaerythritol trinitrate reductase activity
I6J92_RS06190	COG0346	lactoylglutathione lyase activity
I6J92_RS06200	COG1201	RNA secondary structure unwinding
I6J92_RS06205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6J92_RS06210	COG0791	NLP P60 protein
I6J92_RS06215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J92_RS06220	COG2814	Major facilitator Superfamily
I6J92_RS06235	COG0583	DNA-binding transcription factor activity
I6J92_RS06240	COG2814	Major facilitator Superfamily
I6J92_RS06245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J92_RS06250	COG0307	riboflavin synthase, alpha
I6J92_RS06260	COG3468	outer membrane autotransporter barrel domain protein
I6J92_RS06280	COG4529	Protein conserved in bacteria
I6J92_RS06290	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6J92_RS06295	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS06305	COG2414	aldehyde ferredoxin oxidoreductase
I6J92_RS06310	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS06320	COG0469	pyruvate kinase activity
I6J92_RS06325	COG4238	major outer membrane lipoprotein
I6J92_RS06330	COG1376	ErfK ybiS ycfS ynhG family protein
I6J92_RS06345	COG0719	Fe-S assembly protein
I6J92_RS06350	COG0396	ATPase activity
I6J92_RS06355	COG0719	Fe-S assembly protein
I6J92_RS06360	COG0316	Belongs to the HesB IscA family
I6J92_RS06370	COG2050	protein possibly involved in aromatic compounds catabolism
I6J92_RS06375	COG0277	FAD linked oxidase domain protein
I6J92_RS06375	COG0247	lactate metabolic process
I6J92_RS06380	COG0628	permease
I6J92_RS06395	COG0738	Major facilitator superfamily
I6J92_RS06400	COG2271	Major facilitator Superfamily
I6J92_RS06415	COG4670	ketone body catabolic process
I6J92_RS06420	COG1960	acyl-CoA dehydrogenase activity
I6J92_RS06425	COG1917	Cupin 2, conserved barrel domain protein
I6J92_RS06425	COG2207	Transcriptional regulator
I6J92_RS06430	COG2086	electron transfer activity
I6J92_RS06435	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J92_RS06440	COG0644	oxidoreductase
I6J92_RS06445	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J92_RS06450	COG0318	PFAM AMP-dependent synthetase and ligase
I6J92_RS06455	COG0574	Belongs to the PEP-utilizing enzyme family
I6J92_RS06455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J92_RS06465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J92_RS06470	COG4256	Hemin uptake protein
I6J92_RS06480	COG2200	EAL domain
I6J92_RS06485	COG0791	NLP P60 protein
I6J92_RS06495	COG0386	Belongs to the glutathione peroxidase family
I6J92_RS06555	COG3137	Salt-induced outer membrane protein
I6J92_RS06560	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J92_RS06570	COG3001	Fructosamine kinase
I6J92_RS06580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J92_RS06585	COG1988	membrane-bound metal-dependent
I6J92_RS06590	COG1823	symporter activity
I6J92_RS06600	COG0753	catalase activity
I6J92_RS06610	COG1486	melibiose metabolic process
I6J92_RS06615	COG1917	Cupin 2, conserved barrel domain protein
I6J92_RS06615	COG2169	Transcriptional regulator
I6J92_RS06620	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J92_RS06625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J92_RS06630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J92_RS06635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J92_RS06655	COG3678	ATP-independent chaperone mediated protein folding
I6J92_RS06685	COG0708	Exodeoxyribonuclease III
I6J92_RS06690	COG0398	Pfam SNARE associated Golgi protein
I6J92_RS06700	COG0398	Pfam SNARE associated Golgi protein
I6J92_RS06705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J92_RS06710	COG4134	Bacterial extracellular solute-binding protein
I6J92_RS06715	COG4135	transport system, permease component
I6J92_RS06720	COG4136	ATPase activity
I6J92_RS06725	COG2897	thiosulfate sulfurtransferase activity
I6J92_RS06730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J92_RS06745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J92_RS06750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J92_RS06760	COG0778	Nitroreductase
I6J92_RS06765	COG0616	signal peptide processing
I6J92_RS06770	COG0252	asparaginase activity
I6J92_RS06775	COG1335	isochorismatase
I6J92_RS06780	COG2814	Major facilitator Superfamily
I6J92_RS06785	COG1349	DNA-binding transcription factor activity
I6J92_RS06790	COG0667	Aldo Keto reductase
I6J92_RS06795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS06800	COG0191	fructose-bisphosphate aldolase activity
I6J92_RS06805	COG1063	alcohol dehydrogenase
I6J92_RS06810	COG2271	Major facilitator Superfamily
I6J92_RS06815	COG1063	alcohol dehydrogenase
I6J92_RS06820	COG3139	Protein of unknown function (DUF1315)
I6J92_RS06830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J92_RS06835	COG0676	glucose-6-phosphate 1-epimerase activity
I6J92_RS06840	COG0656	L-ascorbic acid biosynthetic process
I6J92_RS06845	COG3713	MltA-interacting MipA family protein
I6J92_RS06850	COG2766	serine protein kinase
I6J92_RS06860	COG2199	diguanylate cyclase activity
I6J92_RS06865	COG2199	diguanylate cyclase activity
I6J92_RS06870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J92_RS06885	COG2207	Transcriptional regulator
I6J92_RS06890	COG2807	transmembrane transport
I6J92_RS06895	COG3189	MarR family transcriptional regulator
I6J92_RS06900	COG3042	response to heat
I6J92_RS06905	COG2203	Gaf domain
I6J92_RS06905	COG2199	diguanylate cyclase activity
I6J92_RS06920	COG2261	transglycosylase associated protein
I6J92_RS06930	COG3615	Tellurite resistance protein tehB
I6J92_RS06940	COG0583	DNA-binding transcription factor activity
I6J92_RS06945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6J92_RS06950	COG0318	PFAM AMP-dependent synthetase and ligase
I6J92_RS06955	COG3065	identical protein binding
I6J92_RS06960	COG1214	PFAM Peptidase M22, glycoprotease
I6J92_RS06965	COG1199	ATP-dependent helicase activity
I6J92_RS06970	COG0251	oxidation-reduction process
I6J92_RS06985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J92_RS06995	COG1760	l-serine dehydratase
I6J92_RS07000	COG2200	EAL domain
I6J92_RS07005	COG1253	flavin adenine dinucleotide binding
I6J92_RS07010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS07010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS07015	COG3715	PTS system
I6J92_RS07020	COG3716	PTS system mannose fructose sorbose family IID component
I6J92_RS07035	COG2226	methyltransferase
I6J92_RS07065	COG1414	Transcriptional regulator
I6J92_RS07070	COG2814	Major facilitator Superfamily
I6J92_RS07080	COG0793	Belongs to the peptidase S41A family
I6J92_RS07090	COG1956	GAF domain-containing protein
I6J92_RS07095	COG2995	paraquat-inducible protein a
I6J92_RS07100	COG3008	intermembrane lipid transfer
I6J92_RS07120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J92_RS07130	COG1276	copper resistance
I6J92_RS07135	COG2372	response to copper ion
I6J92_RS07145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J92_RS07150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J92_RS07155	COG1770	oligopeptidase
I6J92_RS07160	COG2979	Protein of unknown function (DUF533)
I6J92_RS07170	COG3141	response to X-ray
I6J92_RS07180	COG0800	Aldolase
I6J92_RS07185	COG0129	dihydroxy-acid dehydratase activity
I6J92_RS07190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J92_RS07195	COG1737	Transcriptional regulator
I6J92_RS07200	COG0469	pyruvate kinase activity
I6J92_RS07205	COG1560	Kdo2-lipid A biosynthetic process
I6J92_RS07210	COG0739	heme binding
I6J92_RS07215	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6J92_RS07225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J92_RS07255	COG0217	transcriptional regulatory protein
I6J92_RS07260	COG0494	nUDIX hydrolase
I6J92_RS07270	COG1335	isochorismatase
I6J92_RS07275	COG1801	Protein of unknown function DUF72
I6J92_RS07280	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6J92_RS07295	COG0243	molybdopterin cofactor binding
I6J92_RS07300	COG3005	denitrification pathway
I6J92_RS07310	COG3102	Protein conserved in bacteria
I6J92_RS07325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J92_RS07330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J92_RS07335	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6J92_RS07340	COG0745	RESPONSE REGULATOR receiver
I6J92_RS07350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J92_RS07360	COG0840	transmembrane signaling receptor activity
I6J92_RS07365	COG0835	chemotaxis
I6J92_RS07370	COG0643	Histidine kinase
I6J92_RS07370	COG2198	Histidine kinase
I6J92_RS07375	COG1360	Flagellar Motor Protein
I6J92_RS07380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6J92_RS07395	COG0589	response to stress
I6J92_RS07405	COG1877	trehalose-phosphatase activity
I6J92_RS07410	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS07420	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS07425	COG1528	Iron-storage protein
I6J92_RS07445	COG1528	Iron-storage protein
I6J92_RS07455	COG0814	amino acid
I6J92_RS07460	COG3012	SEC-C Motif Domain Protein
I6J92_RS07460	COG3318	Belongs to the UPF0149 family
I6J92_RS07490	COG2197	response regulator
I6J92_RS07505	COG2197	response regulator
I6J92_RS07510	COG1126	abc transporter atp-binding protein
I6J92_RS07515	COG0765	amino acid transport
I6J92_RS07525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS07535	COG1191	sigma factor activity
I6J92_RS07540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J92_RS07545	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6J92_RS07550	COG1516	flagellar protein fliS
I6J92_RS07560	COG0366	Alpha amylase catalytic
I6J92_RS07570	COG2391	methyltransferase activity
I6J92_RS07575	COG0425	Belongs to the sulfur carrier protein TusA family
I6J92_RS07580	COG2135	peptidase activity
I6J92_RS07590	COG2207	Transcriptional regulator
I6J92_RS07595	COG1881	PFAM PEBP family protein
I6J92_RS07600	COG2076	Multidrug Resistance protein
I6J92_RS07610	COG1766	The M ring may be actively involved in energy transduction
I6J92_RS07615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J92_RS07620	COG1317	bacterial-type flagellum organization
I6J92_RS07625	COG1157	protein secretion by the type III secretion system
I6J92_RS07630	COG2882	bacterial-type flagellum organization
I6J92_RS07635	COG3144	bacterial-type flagellum assembly
I6J92_RS07640	COG1580	Controls the rotational direction of flagella during chemotaxis
I6J92_RS07645	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J92_RS07650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J92_RS07655	COG3190	flagellar
I6J92_RS07660	COG1338	Plays a role in the flagellum-specific transport system
I6J92_RS07665	COG1987	bacterial-type flagellum assembly
I6J92_RS07670	COG1684	flagellar biosynthetic protein fliR
I6J92_RS07675	COG2197	response regulator
I6J92_RS07700	COG5475	Uncharacterized small protein (DUF2158)
I6J92_RS07705	COG2354	Protein conserved in bacteria
I6J92_RS07710	COG0697	spore germination
I6J92_RS07715	COG3727	T/G mismatch-specific endonuclease activity
I6J92_RS07720	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J92_RS07725	COG1418	mRNA catabolic process
I6J92_RS07735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J92_RS07745	COG2205	protein histidine kinase activity
I6J92_RS07750	COG0745	RESPONSE REGULATOR receiver
I6J92_RS07755	COG2351	hydroxyisourate hydrolase activity
I6J92_RS07760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J92_RS07765	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6J92_RS07770	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6J92_RS07775	COG0582	viral genome integration into host DNA
I6J92_RS07805	COG4916	TIR domain
I6J92_RS07915	COG0582	viral genome integration into host DNA
I6J92_RS07925	COG2814	Major facilitator Superfamily
I6J92_RS07930	COG1132	(ABC) transporter
I6J92_RS07945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J92_RS07945	COG3433	isochorismatase activity
I6J92_RS07945	COG2226	methyltransferase
I6J92_RS07965	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J92_RS07970	COG4771	TonB-dependent receptor
I6J92_RS07975	COG2373	Large extracellular alpha-helical protein
I6J92_RS07975	COG1388	LysM domain
I6J92_RS07975	COG4932	domain protein
I6J92_RS07990	COG0477	Major facilitator Superfamily
I6J92_RS07995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J92_RS08000	COG0217	transcriptional regulatory protein
I6J92_RS08010	COG0583	DNA-binding transcription factor activity
I6J92_RS08015	COG0583	DNA-binding transcription factor activity
I6J92_RS08025	COG0534	Mate efflux family protein
I6J92_RS08035	COG0582	viral genome integration into host DNA
I6J92_RS08045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J92_RS08070	COG0154	amidase activity
I6J92_RS08100	COG1960	acyl-CoA dehydrogenase activity
I6J92_RS08105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J92_RS08110	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J92_RS08125	COG2197	response regulator
I6J92_RS08145	COG1376	ErfK ybiS ycfS ynhG family protein
I6J92_RS08160	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6J92_RS08165	COG4771	TonB-dependent receptor
I6J92_RS08170	COG1475	DNA binding
I6J92_RS08175	COG3969	phosphoadenosine phosphosulfate
I6J92_RS08180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J92_RS08185	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS08205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS08220	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6J92_RS08255	COG3547	Transposase (IS116 IS110 IS902 family)
I6J92_RS08310	COG1120	ATPase activity
I6J92_RS08315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS08375	COG2003	Belongs to the UPF0758 family
I6J92_RS08420	COG1289	transmembrane transporter activity
I6J92_RS08430	COG1686	Belongs to the peptidase S11 family
I6J92_RS08435	COG2925	Exonuclease
I6J92_RS08440	COG0425	Belongs to the sulfur carrier protein TusA family
I6J92_RS08445	COG2391	methyltransferase activity
I6J92_RS08450	COG0531	amino acid
I6J92_RS08460	COG0583	DNA-binding transcription factor activity
I6J92_RS08465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J92_RS08470	COG4115	mRNA cleavage
I6J92_RS08475	COG2161	toxin-antitoxin pair type II binding
I6J92_RS08490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J92_RS08500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J92_RS08500	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J92_RS08505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J92_RS08525	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J92_RS08530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J92_RS08535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J92_RS08550	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J92_RS08565	COG0438	transferase activity, transferring glycosyl groups
I6J92_RS08575	COG1216	Glycosyl transferase, family 2
I6J92_RS08590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J92_RS08600	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J92_RS08605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J92_RS08615	COG0438	transferase activity, transferring glycosyl groups
I6J92_RS08620	COG2327	Polysaccharide pyruvyl transferase
I6J92_RS08625	COG2244	polysaccharide biosynthetic process
I6J92_RS08630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J92_RS08635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J92_RS08640	COG0662	Cupin 2, conserved barrel domain protein
I6J92_RS08640	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J92_RS08645	COG0297	glycogen (starch) synthase activity
I6J92_RS08650	COG1051	belongs to the nudix hydrolase family
I6J92_RS08655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J92_RS08660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J92_RS08665	COG0110	maltose O-acetyltransferase activity
I6J92_RS08670	COG1216	Glycosyl transferase, family 2
I6J92_RS08680	COG0438	transferase activity, transferring glycosyl groups
I6J92_RS08685	COG1045	serine acetyltransferase
I6J92_RS08690	COG0463	Glycosyl transferase, family 2
I6J92_RS08695	COG3206	protein involved in exopolysaccharide biosynthesis
I6J92_RS08695	COG0489	protein tyrosine kinase activity
I6J92_RS08700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J92_RS08705	COG1596	polysaccharide export
I6J92_RS08715	COG1253	flavin adenine dinucleotide binding
I6J92_RS08720	COG2982	Protein involved in outer membrane biogenesis
I6J92_RS08730	COG0572	uridine kinase
I6J92_RS08735	COG5001	Diguanylate cyclase
I6J92_RS08735	COG3447	MASE1 domain protein
I6J92_RS08735	COG5002	protein histidine kinase activity
I6J92_RS08740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J92_RS08745	COG0443	Heat shock 70 kDa protein
I6J92_RS08750	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6J92_RS08755	COG0631	protein serine/threonine phosphatase activity
I6J92_RS08760	COG4245	von Willebrand factor, type A
I6J92_RS08795	COG2205	protein histidine kinase activity
I6J92_RS08800	COG0745	RESPONSE REGULATOR receiver
I6J92_RS08830	COG0826	peptidase U32
I6J92_RS08850	COG1063	alcohol dehydrogenase
I6J92_RS08855	COG3775	system Galactitol-specific IIC component
I6J92_RS08860	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J92_RS08865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS08880	COG1830	Aldolase
I6J92_RS08885	COG2211	Major facilitator Superfamily
I6J92_RS08890	COG1397	ADP-ribosylglycohydrolase
I6J92_RS08895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS08900	COG2188	Transcriptional regulator
I6J92_RS08905	COG3757	hydrolase, family 25
I6J92_RS08910	COG0351	phosphomethylpyrimidine kinase
I6J92_RS08930	COG5455	response to cobalt ion
I6J92_RS08935	COG3539	Fimbrial protein
I6J92_RS08940	COG3188	usher protein
I6J92_RS08945	COG3121	Chaperone
I6J92_RS08950	COG3539	Fimbrial protein
I6J92_RS08960	COG0489	protein tyrosine kinase activity
I6J92_RS08970	COG3831	ATPase activity
I6J92_RS08975	COG3831	ATPase activity
I6J92_RS08985	COG0714	Associated with various cellular activities
I6J92_RS08990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6J92_RS08995	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J92_RS09000	COG4715	Zinc finger, swim domain protein
I6J92_RS09005	COG4808	Protein conserved in bacteria
I6J92_RS09010	COG4807	Protein conserved in bacteria
I6J92_RS09015	COG3279	Response regulator of the LytR AlgR family
I6J92_RS09020	COG3275	phosphorelay sensor kinase activity
I6J92_RS09025	COG0789	Transcriptional regulator
I6J92_RS09035	COG1174	glycine betaine transport
I6J92_RS09040	COG1125	glycine betaine transport
I6J92_RS09045	COG1174	glycine betaine transport
I6J92_RS09050	COG1732	Glycine betaine
I6J92_RS09055	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J92_RS09060	COG0277	FAD linked oxidase domain protein
I6J92_RS09065	COG1686	Belongs to the peptidase S11 family
I6J92_RS09075	COG0586	Pfam SNARE associated Golgi protein
I6J92_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS09085	COG1538	Outer membrane efflux protein
I6J92_RS09095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J92_RS09105	COG1346	cytolysis
I6J92_RS09115	COG2949	membrane
I6J92_RS09125	COG0493	'glutamate synthase
I6J92_RS09130	COG0167	dihydroorotate dehydrogenase activity
I6J92_RS09130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J92_RS09135	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS09145	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS09150	COG1609	Transcriptional regulator
I6J92_RS09155	COG2311	Membrane
I6J92_RS09175	COG0833	amino acid
I6J92_RS09180	COG0583	DNA-binding transcription factor activity
I6J92_RS09185	COG2855	membrane
I6J92_RS09195	COG1522	sequence-specific DNA binding
I6J92_RS09195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS09205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J92_RS09210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J92_RS09215	COG2313	pseudouridylate synthase activity
I6J92_RS09220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS09225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J92_RS09225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS09225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS09230	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J92_RS09235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS09235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS09240	COG2814	Major facilitator Superfamily
I6J92_RS09255	COG0246	Mannitol dehydrogenase
I6J92_RS09260	COG0523	cobalamin synthesis protein
I6J92_RS09265	COG0671	phosphoesterase, PA-phosphatase related
I6J92_RS09270	COG0791	NLP P60 protein
I6J92_RS09275	COG2200	EAL domain
I6J92_RS09280	COG4166	transmembrane transport
I6J92_RS09285	COG4174	ABC transporter (Permease)
I6J92_RS09290	COG4239	(ABC) transporter, permease
I6J92_RS09295	COG4172	Belongs to the ABC transporter superfamily
I6J92_RS09305	COG2814	Major facilitator Superfamily
I6J92_RS09310	COG1187	pseudouridine synthase activity
I6J92_RS09315	COG1061	Type III restriction enzyme res subunit
I6J92_RS09335	COG3083	sulfuric ester hydrolase activity
I6J92_RS09350	COG2197	response regulator
I6J92_RS09355	COG3088	subunit of a heme lyase
I6J92_RS09355	COG4235	cytochrome complex assembly
I6J92_RS09360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J92_RS09365	COG1138	Cytochrome C-type biogenesis protein
I6J92_RS09375	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J92_RS09380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J92_RS09385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J92_RS09390	COG4133	protoheme IX ABC transporter activity
I6J92_RS09395	COG3005	denitrification pathway
I6J92_RS09400	COG3043	anaerobic respiration
I6J92_RS09405	COG0348	domain, Protein
I6J92_RS09410	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS09420	COG3062	negative regulation of establishment of protein localization
I6J92_RS09425	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS09425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS09440	COG0579	oxidoreductase
I6J92_RS09445	COG4615	Cyclic peptide transporter
I6J92_RS09450	COG3145	DNA-N1-methyladenine dioxygenase activity
I6J92_RS09455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J92_RS09455	COG2169	Transcriptional regulator
I6J92_RS09460	COG1477	protein flavinylation
I6J92_RS09465	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J92_RS09470	COG2198	Histidine kinase
I6J92_RS09470	COG0642	Histidine kinase
I6J92_RS09475	COG2197	response regulator
I6J92_RS09480	COG0784	Response regulator, receiver
I6J92_RS09480	COG2205	protein histidine kinase activity
I6J92_RS09485	COG3852	Histidine kinase
I6J92_RS09490	COG2204	response regulator
I6J92_RS09495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J92_RS09500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J92_RS09505	COG2031	fatty acid transporter
I6J92_RS09510	COG0183	Belongs to the thiolase family
I6J92_RS09515	COG4676	Protein conserved in bacteria
I6J92_RS09520	COG5445	Predicted secreted protein (DUF2300)
I6J92_RS09525	COG2373	Large extracellular alpha-helical protein
I6J92_RS09530	COG3234	Protein of unknown function (DUF1175)
I6J92_RS09535	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6J92_RS09540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J92_RS09555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J92_RS09560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J92_RS09565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J92_RS09570	COG3642	lipopolysaccharide core region biosynthetic process
I6J92_RS09575	COG0584	glycerophosphoryl diester phosphodiesterase
I6J92_RS09580	COG2271	Major facilitator Superfamily
I6J92_RS09585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J92_RS09595	COG0247	lactate metabolic process
I6J92_RS09600	COG5464	transposase or invertase
I6J92_RS09615	COG2271	Major facilitator Superfamily
I6J92_RS09620	COG4948	Mandelate Racemase Muconate Lactonizing
I6J92_RS09625	COG1414	Transcriptional regulator
I6J92_RS09670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J92_RS09690	COG0318	PFAM AMP-dependent synthetase and ligase
I6J92_RS09695	COG1441	menaquinone biosynthetic process
I6J92_RS09700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J92_RS09715	COG1169	isochorismate synthase
I6J92_RS09720	COG4575	ribosome binding
I6J92_RS09725	COG2153	protein acetylation
I6J92_RS09735	COG2304	oxidoreductase activity
I6J92_RS09740	COG2234	aminopeptidase activity
I6J92_RS09755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J92_RS09760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J92_RS09770	COG0839	Belongs to the complex I subunit 6 family
I6J92_RS09785	COG1034	ATP synthesis coupled electron transport
I6J92_RS09790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J92_RS09795	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6J92_RS09815	COG0583	DNA-binding transcription factor activity
I6J92_RS09820	COG0436	Aminotransferase
I6J92_RS09830	COG0471	metal ion transport
I6J92_RS09830	COG0490	domain, Protein
I6J92_RS09835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J92_RS09850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J92_RS09855	COG0857	belongs to the CobB CobQ family
I6J92_RS09855	COG0280	phosphate acetyltransferase
I6J92_RS09860	COG1288	antiporter activity
I6J92_RS09865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J92_RS09870	COG0622	Phosphoesterase
I6J92_RS09875	COG0625	glutathione transferase activity
I6J92_RS09880	COG0625	glutathione transferase activity
I6J92_RS09885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J92_RS09890	COG1090	epimerase
I6J92_RS09895	COG5464	transposase or invertase
I6J92_RS09900	COG4598	ABC transporter
I6J92_RS09905	COG4160	amino acid transport
I6J92_RS09910	COG4215	(ABC) transporter
I6J92_RS09915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS09925	COG0163	prenyltransferase activity
I6J92_RS09930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J92_RS09935	COG1286	toxin biosynthetic process
I6J92_RS09940	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6J92_RS09945	COG0285	dihydrofolate synthase activity
I6J92_RS09955	COG0586	Pfam SNARE associated Golgi protein
I6J92_RS09965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J92_RS09980	COG2814	Major facilitator Superfamily
I6J92_RS09985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J92_RS10000	COG3101	peptidyl-lysine hydroxylation
I6J92_RS10005	COG0730	response to heat
I6J92_RS10035	COG3539	Fimbrial protein
I6J92_RS10040	COG3539	Fimbrial protein
I6J92_RS10045	COG3539	Fimbrial protein
I6J92_RS10050	COG3121	Chaperone
I6J92_RS10055	COG3188	usher protein
I6J92_RS10060	COG3539	Fimbrial protein
I6J92_RS10065	COG2062	phosphohistidine phosphatase, SixA
I6J92_RS10080	COG3691	Protein conserved in bacteria
I6J92_RS10085	COG2067	long-chain fatty acid transport protein
I6J92_RS10095	COG2116	formate transmembrane transporter activity
I6J92_RS10110	COG2610	gluconate transmembrane transporter activity
I6J92_RS10115	COG3048	D-serine ammonia-lyase activity
I6J92_RS10120	COG0477	Major facilitator Superfamily
I6J92_RS10125	COG1566	PFAM secretion protein HlyD family protein
I6J92_RS10130	COG2197	response regulator
I6J92_RS10135	COG0784	Response regulator, receiver
I6J92_RS10135	COG2205	protein histidine kinase activity
I6J92_RS10135	COG2198	Histidine kinase
I6J92_RS10135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS10140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J92_RS10145	COG0679	Auxin Efflux Carrier
I6J92_RS10150	COG0028	Belongs to the TPP enzyme family
I6J92_RS10175	COG1560	Kdo2-lipid A biosynthetic process
I6J92_RS10185	COG0436	Aminotransferase
I6J92_RS10190	COG3275	phosphorelay sensor kinase activity
I6J92_RS10195	COG3279	Response regulator of the LytR AlgR family
I6J92_RS10200	COG2207	Transcriptional regulator
I6J92_RS10205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS10205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS10205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J92_RS10210	COG1363	Peptidase, m42
I6J92_RS10215	COG0006	proline dipeptidase activity
I6J92_RS10220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS10225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS10250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J92_RS10255	COG2200	EAL domain
I6J92_RS10255	COG2199	diguanylate cyclase activity
I6J92_RS10270	COG3415	Transposase
I6J92_RS10275	COG3415	Transposase
I6J92_RS10305	COG0583	DNA-binding transcription factor activity
I6J92_RS10315	COG2211	Major facilitator Superfamily
I6J92_RS10320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J92_RS10330	COG0583	DNA-binding transcription factor activity
I6J92_RS10335	COG0385	Bile acid
I6J92_RS10340	COG3530	Putative quorum-sensing-regulated virulence factor
I6J92_RS10360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J92_RS10365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS10370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J92_RS10375	COG2190	(PTS) system
I6J92_RS10390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J92_RS10395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J92_RS10400	COG4208	sulfate ABC transporter
I6J92_RS10405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J92_RS10410	COG4150	thiosulfate binding
I6J92_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS10430	COG2837	iron assimilation
I6J92_RS10450	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J92_RS10460	COG2207	Transcriptional regulator
I6J92_RS10465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J92_RS10470	COG4816	utilization protein
I6J92_RS10480	COG4303	Ethanolamine ammonia lyase large subunit
I6J92_RS10485	COG4819	ethanolamine utilization protein
I6J92_RS10490	COG3192	ethanolamine utilization protein
I6J92_RS10495	COG1454	alcohol dehydrogenase
I6J92_RS10500	COG4820	ethanolamine utilization protein (EutJ)
I6J92_RS10505	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS10510	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6J92_RS10515	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6J92_RS10520	COG0280	phosphate acetyltransferase
I6J92_RS10525	COG4812	Cobalamin adenosyltransferase
I6J92_RS10530	COG4766	ethanolamine catabolic process
I6J92_RS10535	COG4917	ethanolamine utilization protein
I6J92_RS10540	COG4810	utilization protein
I6J92_RS10545	COG0281	malic enzyme
I6J92_RS10545	COG0280	phosphate acetyltransferase
I6J92_RS10550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J92_RS10555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J92_RS10560	COG5342	invasion associated locus B
I6J92_RS10570	COG0493	'glutamate synthase
I6J92_RS10570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS10575	COG3850	Histidine kinase
I6J92_RS10580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J92_RS10590	COG1393	Belongs to the ArsC family
I6J92_RS10605	COG0400	carboxylic ester hydrolase activity
I6J92_RS10615	COG2321	neutral zinc metallopeptidase
I6J92_RS10625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6J92_RS10635	COG2716	regulation of RNA biosynthetic process
I6J92_RS10640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J92_RS10645	COG0628	permease
I6J92_RS10650	COG4783	chaperone-mediated protein folding
I6J92_RS10655	COG1393	Belongs to the ArsC family
I6J92_RS10665	COG2233	PERMEase
I6J92_RS10680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J92_RS10685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J92_RS10690	COG0248	Ppx GppA phosphatase
I6J92_RS10695	COG2200	EAL domain
I6J92_RS10710	COG3133	Outer membrane lipoprotein
I6J92_RS10740	COG0516	GMP reductase activity
I6J92_RS10740	COG0517	IMP dehydrogenase activity
I6J92_RS10765	COG1645	bacterial-type flagellum-dependent swarming motility
I6J92_RS10780	COG2976	Protein conserved in bacteria
I6J92_RS10810	COG4953	penicillin-binding protein 1C
I6J92_RS10815	COG2373	Large extracellular alpha-helical protein
I6J92_RS10820	COG2897	thiosulfate sulfurtransferase activity
I6J92_RS10835	COG2975	iron-sulfur cluster assembly
I6J92_RS10840	COG0633	Ferredoxin
I6J92_RS10860	COG0822	iron-sulfur transferase activity
I6J92_RS10880	COG0483	inositol monophosphate 1-phosphatase activity
I6J92_RS10885	COG1073	alpha beta
I6J92_RS10890	COG3711	transcriptional antiterminator
I6J92_RS10895	COG2814	Major facilitator Superfamily
I6J92_RS10900	COG2259	Doxx family
I6J92_RS10905	COG2017	converts alpha-aldose to the beta-anomer
I6J92_RS10910	COG1063	alcohol dehydrogenase
I6J92_RS10915	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS10920	COG1129	ABC transporter
I6J92_RS10925	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS10930	COG0457	Tetratricopeptide repeat
I6J92_RS10935	COG1940	carbohydrate kinase activity
I6J92_RS10945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J92_RS10945	COG1017	nitric oxide dioxygenase activity
I6J92_RS10950	COG0347	Belongs to the P(II) protein family
I6J92_RS10955	COG2204	response regulator
I6J92_RS10960	COG3170	Tfp pilus assembly protein FimV
I6J92_RS10965	COG2205	protein histidine kinase activity
I6J92_RS10970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J92_RS10970	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J92_RS10980	COG0590	tRNA wobble adenosine to inosine editing
I6J92_RS10985	COG0560	Phosphoserine phosphatase
I6J92_RS10990	COG1737	Transcriptional regulator
I6J92_RS10995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS11010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J92_RS11030	COG0681	Belongs to the peptidase S26 family
I6J92_RS11040	COG3086	response to oxidative stress
I6J92_RS11045	COG3026	antisigma factor binding
I6J92_RS11050	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6J92_RS11055	COG1595	DNA-templated transcription, initiation
I6J92_RS11065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J92_RS11075	COG0513	Belongs to the DEAD box helicase family
I6J92_RS11080	COG0583	DNA-binding transcription factor activity
I6J92_RS11100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J92_RS11105	COG3118	belongs to the thioredoxin family
I6J92_RS11110	COG3148	PFAM DTW domain containing protein
I6J92_RS11115	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J92_RS11115	COG1042	CoA-binding domain protein
I6J92_RS11115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J92_RS11120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J92_RS11125	COG5544	Lipoprotein
I6J92_RS11130	COG0477	Major facilitator Superfamily
I6J92_RS11165	COG0542	response to heat
I6J92_RS11175	COG0564	pseudouridine synthase activity
I6J92_RS11180	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J92_RS11185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J92_RS11195	COG0077	Prephenate dehydratase
I6J92_RS11195	COG1605	Chorismate mutase
I6J92_RS11200	COG0287	Prephenate dehydrogenase
I6J92_RS11200	COG1605	Chorismate mutase
I6J92_RS11205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J92_RS11220	COG2199	diguanylate cyclase activity
I6J92_RS11225	COG2885	chlorophyll binding
I6J92_RS11250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J92_RS11255	COG4137	Cytochrome C assembly protein
I6J92_RS11260	COG4536	flavin adenine dinucleotide binding
I6J92_RS11275	COG0497	DNA recombination
I6J92_RS11280	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J92_RS11290	COG2867	negative regulation of translational initiation
I6J92_RS11310	COG0579	oxidoreductase
I6J92_RS11315	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS11320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J92_RS11325	COG1113	amino acid transport
I6J92_RS11330	COG1802	Transcriptional regulator
I6J92_RS11335	COG1652	LysM domain
I6J92_RS11340	COG0401	homolog of Blt101
I6J92_RS11345	COG0640	Transcriptional regulator
I6J92_RS11350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J92_RS11355	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6J92_RS11370	COG4575	ribosome binding
I6J92_RS11380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J92_RS11385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J92_RS11395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J92_RS11400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J92_RS11405	COG4175	Glycine betaine
I6J92_RS11410	COG4176	ABC-type proline glycine betaine transport system permease component
I6J92_RS11415	COG2113	Glycine betaine
I6J92_RS11420	COG2814	Major facilitator Superfamily
I6J92_RS11425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J92_RS11435	COG1846	Transcriptional regulator
I6J92_RS11440	COG1566	PFAM secretion protein HlyD family protein
I6J92_RS11445	COG2814	Major facilitator Superfamily
I6J92_RS11470	COG1238	metal cluster binding
I6J92_RS11475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J92_RS11510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6J92_RS11530	COG1546	Belongs to the CinA family
I6J92_RS11535	COG2951	lytic endotransglycosylase activity
I6J92_RS11540	COG3730	PTS system glucitol sorbitol-specific
I6J92_RS11545	COG3732	PTS system glucitol sorbitol-specific
I6J92_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS11560	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS11565	COG1349	DNA-binding transcription factor activity
I6J92_RS11570	COG0517	IMP dehydrogenase activity
I6J92_RS11570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J92_RS11590	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J92_RS11595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS11605	COG5499	transcription regulator containing HTH domain
I6J92_RS11610	COG4680	protein conserved in bacteria
I6J92_RS11620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J92_RS11630	COG3260	NADH ubiquinone oxidoreductase 20
I6J92_RS11635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J92_RS11640	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6J92_RS11640	COG3261	NADH dehydrogenase
I6J92_RS11645	COG0650	Formate hydrogenlyase subunit 4
I6J92_RS11650	COG0651	ATP synthesis coupled electron transport
I6J92_RS11655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS11665	COG0375	protein maturation
I6J92_RS11670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J92_RS11675	COG0298	carbon dioxide binding
I6J92_RS11680	COG0409	Hydrogenase expression formation protein
I6J92_RS11685	COG0309	Hydrogenase expression formation protein (HypE)
I6J92_RS11690	COG3604	Transcriptional regulator
I6J92_RS11740	COG0582	viral genome integration into host DNA
I6J92_RS11750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J92_RS11755	COG1349	DNA-binding transcription factor activity
I6J92_RS11760	COG2084	Dehydrogenase
I6J92_RS11765	COG3395	kinase activity
I6J92_RS11770	COG0235	Class ii aldolase
I6J92_RS11775	COG3622	Belongs to the hyi family
I6J92_RS11780	COG2610	gluconate transmembrane transporter activity
I6J92_RS11795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J92_RS11800	COG4942	peptidase
I6J92_RS11800	COG1388	LysM domain
I6J92_RS11815	COG0585	pseudouridine synthase activity
I6J92_RS11855	COG2234	aminopeptidase activity
I6J92_RS11875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J92_RS11880	COG0720	synthase
I6J92_RS11885	COG0644	oxidoreductase
I6J92_RS11890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J92_RS11895	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J92_RS11900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J92_RS11905	COG2086	electron transfer activity
I6J92_RS11910	COG0477	Major facilitator Superfamily
I6J92_RS11915	COG0277	FAD linked oxidase domain protein
I6J92_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS11925	COG2223	nitrite transmembrane transporter activity
I6J92_RS11930	COG1070	Carbohydrate kinase
I6J92_RS11935	COG0602	queuosine metabolic process
I6J92_RS11945	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J92_RS11955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J92_RS11970	COG3956	TIGRFAM MazG family protein
I6J92_RS11975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J92_RS11985	COG3850	Histidine kinase
I6J92_RS11985	COG3437	response regulator, receiver
I6J92_RS11985	COG4999	Histidine kinase
I6J92_RS11985	COG2205	protein histidine kinase activity
I6J92_RS11990	COG4948	Mandelate Racemase Muconate Lactonizing
I6J92_RS11995	COG4948	Mandelate Racemase Muconate Lactonizing
I6J92_RS12000	COG2271	Major facilitator Superfamily
I6J92_RS12005	COG0716	FMN binding
I6J92_RS12010	COG0564	pseudouridine synthase activity
I6J92_RS12015	COG3098	single-species biofilm formation
I6J92_RS12030	COG1611	Belongs to the LOG family
I6J92_RS12035	COG0814	amino acid
I6J92_RS12040	COG1760	l-serine dehydratase
I6J92_RS12050	COG1454	alcohol dehydrogenase
I6J92_RS12055	COG0235	Class ii aldolase
I6J92_RS12060	COG0738	Major facilitator superfamily
I6J92_RS12070	COG1070	Carbohydrate kinase
I6J92_RS12080	COG1349	DNA-binding transcription factor activity
I6J92_RS12090	COG2363	Small membrane protein
I6J92_RS12095	COG0583	DNA-binding transcription factor activity
I6J92_RS12105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J92_RS12110	COG2166	iron-sulfur cluster assembly
I6J92_RS12115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J92_RS12120	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6J92_RS12160	COG2885	chlorophyll binding
I6J92_RS12285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J92_RS12290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS12290	COG1263	PTS System
I6J92_RS12295	COG3711	transcriptional antiterminator
I6J92_RS12300	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J92_RS12305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J92_RS12305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J92_RS12310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J92_RS12315	COG1074	ATP-dependent DNA helicase activity
I6J92_RS12320	COG1025	Belongs to the peptidase M16 family
I6J92_RS12325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J92_RS12330	COG4967	type IV pilus modification protein PilV
I6J92_RS12340	COG4795	General secretion pathway protein
I6J92_RS12345	COG2165	general secretion pathway protein
I6J92_RS12360	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6J92_RS12375	COG0861	Integral membrane protein TerC family
I6J92_RS12385	COG0667	Aldo Keto reductase
I6J92_RS12400	COG1609	Transcriptional regulator
I6J92_RS12410	COG0583	DNA-binding transcription factor activity
I6J92_RS12415	COG1794	racemase activity, acting on amino acids and derivatives
I6J92_RS12420	COG2814	Major facilitator Superfamily
I6J92_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS12435	COG0183	Belongs to the thiolase family
I6J92_RS12440	COG0814	amino acid
I6J92_RS12450	COG4942	peptidase
I6J92_RS12455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J92_RS12460	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J92_RS12465	COG2080	2 iron, 2 sulfur cluster binding
I6J92_RS12470	COG3829	transcription factor binding
I6J92_RS12475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J92_RS12480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J92_RS12485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J92_RS12495	COG0549	Belongs to the carbamate kinase family
I6J92_RS12500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J92_RS12500	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J92_RS12505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J92_RS12510	COG2068	MobA-Related Protein
I6J92_RS12515	COG0493	'glutamate synthase
I6J92_RS12515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS12520	COG0402	S-adenosylhomocysteine deaminase activity
I6J92_RS12525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J92_RS12530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J92_RS12530	COG2080	2 iron, 2 sulfur cluster binding
I6J92_RS12535	COG2233	PERMEase
I6J92_RS12540	COG0402	S-adenosylhomocysteine deaminase activity
I6J92_RS12545	COG2252	PERMEase
I6J92_RS12550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS12555	COG0493	'glutamate synthase
I6J92_RS12555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS12560	COG2233	PERMEase
I6J92_RS12580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J92_RS12590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J92_RS12595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J92_RS12600	COG4974	Belongs to the 'phage' integrase family
I6J92_RS12605	COG0716	FMN binding
I6J92_RS12615	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J92_RS12625	COG1272	protein, Hemolysin III
I6J92_RS12635	COG2723	6-phospho-beta-galactosidase activity
I6J92_RS12660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J92_RS12665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J92_RS12670	COG0006	proline dipeptidase activity
I6J92_RS12690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J92_RS12700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J92_RS12720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J92_RS12720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J92_RS12725	COG0583	DNA-binding transcription factor activity
I6J92_RS12730	COG2968	Membrane
I6J92_RS12735	COG1279	arginine transmembrane transporter activity
I6J92_RS12740	COG0668	transmembrane transport
I6J92_RS12745	COG0191	fructose-bisphosphate aldolase activity
I6J92_RS12785	COG1122	ATPase activity
I6J92_RS12790	COG1072	(Pantothenic acid kinase))
I6J92_RS12805	COG1063	alcohol dehydrogenase
I6J92_RS12810	COG2213	PTS system mannitol-specific
I6J92_RS12815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS12820	COG0330	HflC and HflK could
I6J92_RS12825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J92_RS12830	COG0501	Belongs to the peptidase M48B family
I6J92_RS12845	COG1166	arginine decarboxylase activity
I6J92_RS12865	COG2814	Major facilitator Superfamily
I6J92_RS12875	COG2356	endonuclease I
I6J92_RS12880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J92_RS12885	COG0189	ligase activity
I6J92_RS12900	COG2805	Type II/IV secretion system protein
I6J92_RS12905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J92_RS12910	COG0762	integral membrane protein
I6J92_RS12920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J92_RS12925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J92_RS12935	COG0252	asparaginase activity
I6J92_RS12945	COG3171	Protein conserved in bacteria
I6J92_RS12955	COG1194	a g-specific adenine glycosylase
I6J92_RS12970	COG2211	Major facilitator Superfamily
I6J92_RS12975	COG1982	Orn Lys Arg decarboxylase major
I6J92_RS12980	COG1811	Na channel or pump
I6J92_RS12990	COG0582	viral genome integration into host DNA
I6J92_RS13000	COG2194	sulfuric ester hydrolase activity
I6J92_RS13035	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6J92_RS13185	COG3436	PFAM IS66 Orf2 family protein
I6J92_RS13195	COG2271	Major facilitator Superfamily
I6J92_RS13260	COG2194	sulfuric ester hydrolase activity
I6J92_RS13275	COG4413	Urea transporter
I6J92_RS13285	COG2274	protein secretion by the type I secretion system
I6J92_RS13305	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J92_RS13310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J92_RS13315	COG1121	(ABC) transporter
I6J92_RS13380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J92_RS13385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS13390	COG3842	ATPase activity
I6J92_RS13415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J92_RS13425	COG0583	DNA-binding transcription factor activity
I6J92_RS13465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J92_RS13515	COG4771	TonB-dependent receptor
I6J92_RS13530	COG4584	PFAM Integrase catalytic
I6J92_RS13535	COG1484	DNA-dependent DNA replication
I6J92_RS13560	COG3596	GTP binding
I6J92_RS13565	COG2378	regulation of single-species biofilm formation
I6J92_RS13590	COG2003	Belongs to the UPF0758 family
I6J92_RS13605	COG3344	reverse transcriptase
I6J92_RS13670	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS13680	COG0110	maltose O-acetyltransferase activity
I6J92_RS13685	COG0562	UDP-galactopyranose mutase
I6J92_RS13690	COG1216	Glycosyl transferase, family 2
I6J92_RS13715	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J92_RS13745	COG2165	general secretion pathway protein
I6J92_RS13750	COG1459	type II secretion system
I6J92_RS13755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J92_RS13775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J92_RS13780	COG3064	Membrane
I6J92_RS13785	COG1620	l-lactate permease
I6J92_RS13790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J92_RS13795	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6J92_RS13800	COG0247	lactate metabolic process
I6J92_RS13805	COG0277	FAD linked oxidase domain protein
I6J92_RS13810	COG0277	FAD linked oxidase domain protein
I6J92_RS13815	COG2186	Transcriptional regulator
I6J92_RS13820	COG0456	acetyltransferase
I6J92_RS13825	COG0318	PFAM AMP-dependent synthetase and ligase
I6J92_RS13835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J92_RS13840	COG0156	8-amino-7-oxononanoate synthase activity
I6J92_RS13855	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6J92_RS13865	COG2244	polysaccharide biosynthetic process
I6J92_RS13870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J92_RS13875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J92_RS13880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J92_RS13885	COG0306	phosphate transporter
I6J92_RS13890	COG0754	glutathionylspermidine amidase activity
I6J92_RS13895	COG0625	glutathione transferase activity
I6J92_RS13900	COG0298	carbon dioxide binding
I6J92_RS13905	COG0375	protein maturation
I6J92_RS13910	COG1773	rubredoxin
I6J92_RS13915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J92_RS13920	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J92_RS13925	COG5557	Pfam Polysulphide reductase, NrfD
I6J92_RS13930	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS13935	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6J92_RS13950	COG0667	Aldo Keto reductase
I6J92_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS13965	COG0848	biopolymer transport protein
I6J92_RS13970	COG0811	peptide transport
I6J92_RS13975	COG0626	cystathionine gamma-synthase activity
I6J92_RS13980	COG0586	Pfam SNARE associated Golgi protein
I6J92_RS13985	COG2207	Transcriptional regulator
I6J92_RS13990	COG1979	alcohol dehydrogenase
I6J92_RS13995	COG0656	L-ascorbic acid biosynthetic process
I6J92_RS14005	COG4238	major outer membrane lipoprotein
I6J92_RS14010	COG1032	radical SAM domain protein
I6J92_RS14015	COG2186	Transcriptional regulator
I6J92_RS14020	COG0246	Mannitol dehydrogenase
I6J92_RS14025	COG1063	alcohol dehydrogenase
I6J92_RS14030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J92_RS14050	COG2132	Multicopper oxidase
I6J92_RS14055	COG0204	Acyl-transferase
I6J92_RS14060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J92_RS14065	COG4166	transmembrane transport
I6J92_RS14070	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J92_RS14075	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J92_RS14080	COG0745	RESPONSE REGULATOR receiver
I6J92_RS14085	COG0642	Histidine kinase
I6J92_RS14100	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J92_RS14105	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J92_RS14110	COG1737	Transcriptional regulator
I6J92_RS14120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS14125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS14130	COG1120	ATPase activity
I6J92_RS14135	COG4774	siderophore transport
I6J92_RS14140	COG0187	DNA topoisomerase II activity
I6J92_RS14145	COG3150	esterase
I6J92_RS14150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J92_RS14155	COG3151	Protein conserved in bacteria
I6J92_RS14160	COG0494	nUDIX hydrolase
I6J92_RS14165	COG1538	Outer membrane efflux protein
I6J92_RS14175	COG0754	glutathionylspermidine amidase activity
I6J92_RS14185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J92_RS14195	COG3384	dioxygenase
I6J92_RS14210	COG3539	Fimbrial protein
I6J92_RS14215	COG3188	usher protein
I6J92_RS14220	COG3121	Chaperone
I6J92_RS14225	COG3539	Fimbrial protein
I6J92_RS14245	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J92_RS14250	COG2268	Band 7 protein
I6J92_RS14265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J92_RS14270	COG3025	triphosphatase activity
I6J92_RS14280	COG0675	Transposase, IS605 OrfB family
I6J92_RS14285	COG4991	sh3 domain protein
I6J92_RS14290	COG0617	tRNA 3'-terminal CCA addition
I6J92_RS14300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J92_RS14320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J92_RS14325	COG0471	metal ion transport
I6J92_RS14335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J92_RS14340	COG0358	DNA primase activity
I6J92_RS14345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J92_RS14365	COG4220	transposase activity
I6J92_RS14430	COG2375	cellular response to nickel ion
I6J92_RS14435	COG1695	Transcriptional regulator
I6J92_RS14440	COG0840	transmembrane signaling receptor activity
I6J92_RS14450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J92_RS14455	COG1609	Transcriptional regulator
I6J92_RS14460	COG3250	beta-galactosidase activity
I6J92_RS14465	COG2731	YhcH YjgK YiaL family protein
I6J92_RS14470	COG0531	amino acid
I6J92_RS14480	COG3408	Glycogen debranching enzyme
I6J92_RS14480	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6J92_RS14485	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J92_RS14485	COG1902	pentaerythritol trinitrate reductase activity
I6J92_RS14490	COG5499	transcription regulator containing HTH domain
I6J92_RS14505	COG1451	nucleotide metabolic process
I6J92_RS14510	COG2949	membrane
I6J92_RS14515	COG0673	inositol 2-dehydrogenase activity
I6J92_RS14520	COG0861	Integral membrane protein TerC family
I6J92_RS14535	COG2721	sulfolactate sulfo-lyase activity
I6J92_RS14545	COG2271	Major facilitator Superfamily
I6J92_RS14550	COG2186	Transcriptional regulator
I6J92_RS14555	COG0586	Pfam SNARE associated Golgi protein
I6J92_RS14565	COG1422	Protein of unknown function (DUF1090)
I6J92_RS14570	COG4575	ribosome binding
I6J92_RS14575	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6J92_RS14585	COG2259	Doxx family
I6J92_RS14590	COG0435	Glutathione S-transferase
I6J92_RS14595	COG3152	Membrane
I6J92_RS14600	COG0583	DNA-binding transcription factor activity
I6J92_RS14605	COG1741	Belongs to the pirin family
I6J92_RS14620	COG0814	amino acid
I6J92_RS14625	COG1760	l-serine dehydratase
I6J92_RS14630	COG0251	oxidation-reduction process
I6J92_RS14635	COG1882	Formate acetyltransferase
I6J92_RS14640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J92_RS14650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J92_RS14655	COG0583	DNA-binding transcription factor activity
I6J92_RS14670	COG1929	Belongs to the glycerate kinase type-1 family
I6J92_RS14675	COG2084	Dehydrogenase
I6J92_RS14685	COG2271	Major facilitator Superfamily
I6J92_RS14690	COG2721	sulfolactate sulfo-lyase activity
I6J92_RS14695	COG1349	DNA-binding transcription factor activity
I6J92_RS14705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS14715	COG3716	PTS system mannose fructose sorbose family IID component
I6J92_RS14720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS14725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J92_RS14730	COG2222	sugar isomerase
I6J92_RS14740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS14745	COG3715	PTS system
I6J92_RS14750	COG3716	PTS system mannose fructose sorbose family IID component
I6J92_RS14755	COG0363	glucosamine-6-phosphate deaminase activity
I6J92_RS14760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J92_RS14780	COG2823	Periplasmic or secreted lipoprotein
I6J92_RS14785	COG0701	Predicted permease
I6J92_RS14790	COG0702	epimerase
I6J92_RS14795	COG0693	protein deglycase activity
I6J92_RS14810	COG3153	acetyltransferase
I6J92_RS14815	COG3154	lipid carrier protein
I6J92_RS14820	COG0826	peptidase U32
I6J92_RS14825	COG0826	peptidase U32
I6J92_RS14830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J92_RS14835	COG0814	amino acid
I6J92_RS14840	COG0513	Belongs to the DEAD box helicase family
I6J92_RS14880	COG0195	Participates in both transcription termination and antitermination
I6J92_RS14900	COG2194	sulfuric ester hydrolase activity
I6J92_RS14910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J92_RS14920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J92_RS14925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J92_RS14935	COG1534	Rna-binding protein
I6J92_RS14940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J92_RS14945	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J92_RS14955	COG0697	spore germination
I6J92_RS14970	COG0142	geranyltranstransferase activity
I6J92_RS14975	COG3423	Transcriptional regulator
I6J92_RS14985	COG5007	Belongs to the BolA IbaG family
I6J92_RS14990	COG3113	response to antibiotic
I6J92_RS14995	COG2854	intermembrane phospholipid transfer
I6J92_RS15000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J92_RS15005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J92_RS15010	COG1127	ABC transporter
I6J92_RS15015	COG0530	calcium, potassium:sodium antiporter activity
I6J92_RS15020	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J92_RS15020	COG0517	IMP dehydrogenase activity
I6J92_RS15025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J92_RS15030	COG3117	lipopolysaccharide transmembrane transporter activity
I6J92_RS15035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J92_RS15040	COG1137	ATPase activity
I6J92_RS15045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6J92_RS15050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J92_RS15065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS15070	COG0515	serine threonine protein kinase
I6J92_RS15080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J92_RS15085	COG5002	protein histidine kinase activity
I6J92_RS15085	COG2198	Histidine kinase
I6J92_RS15085	COG0784	Response regulator, receiver
I6J92_RS15090	COG1242	4 iron, 4 sulfur cluster binding
I6J92_RS15095	COG0070	glutamate synthase
I6J92_RS15095	COG0069	glutamate synthase activity
I6J92_RS15095	COG0067	glutamate synthase
I6J92_RS15100	COG0493	'glutamate synthase
I6J92_RS15105	COG4804	nuclease activity
I6J92_RS15110	COG2731	YhcH YjgK YiaL family protein
I6J92_RS15125	COG2814	Major facilitator Superfamily
I6J92_RS15140	COG2969	positive regulation of protein catabolic process
I6J92_RS15145	COG0625	glutathione transferase activity
I6J92_RS15160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J92_RS15165	COG3105	Protein conserved in bacteria
I6J92_RS15170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J92_RS15175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J92_RS15195	COG2732	(Barnase) inhibitor
I6J92_RS15215	COG0583	DNA-binding transcription factor activity
I6J92_RS15220	COG0312	modulator of DNA gyrase
I6J92_RS15225	COG3164	Protein of unknown function
I6J92_RS15230	COG1530	ribonuclease E activity
I6J92_RS15240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J92_RS15245	COG1792	Involved in formation and maintenance of cell shape
I6J92_RS15250	COG1077	Cell shape determining protein MreB Mrl
I6J92_RS15255	COG2199	diguanylate cyclase activity
I6J92_RS15255	COG2200	EAL domain
I6J92_RS15260	COG0604	alcohol dehydrogenase
I6J92_RS15265	COG0511	ligase activity, forming carbon-carbon bonds
I6J92_RS15270	COG0439	Biotin carboxylase
I6J92_RS15280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS15285	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS15290	COG1129	ABC transporter
I6J92_RS15295	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS15305	COG1349	DNA-binding transcription factor activity
I6J92_RS15310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS15315	COG3924	membrane
I6J92_RS15320	COG4145	pantothenate transmembrane transporter activity
I6J92_RS15330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J92_RS15340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6J92_RS15350	COG1309	transcriptional regulator
I6J92_RS15355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS15360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J92_RS15370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J92_RS15375	COG4597	amino acid ABC transporter
I6J92_RS15380	COG0765	amino acid transport
I6J92_RS15385	COG1126	abc transporter atp-binding protein
I6J92_RS15425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J92_RS15440	COG0009	L-threonylcarbamoyladenylate synthase
I6J92_RS15445	COG0551	DNA topoisomerase type I activity
I6J92_RS15455	COG0758	DNA mediated transformation
I6J92_RS15465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J92_RS15470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J92_RS15470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J92_RS15475	COG0569	domain protein
I6J92_RS15485	COG3036	rescue of stalled ribosome
I6J92_RS15490	COG0789	Transcriptional regulator
I6J92_RS15530	COG0201	protein transport
I6J92_RS15620	COG0089	rRNA binding
I6J92_RS15645	COG3267	Type II secretory pathway component ExeA
I6J92_RS15645	COG3409	Peptidoglycan-binding domain 1 protein
I6J92_RS15650	COG3031	protein transport across the cell outer membrane
I6J92_RS15655	COG1450	Type ii and iii secretion system protein
I6J92_RS15660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J92_RS15665	COG1459	type II secretion system
I6J92_RS15670	COG2165	general secretion pathway protein
I6J92_RS15675	COG2165	general secretion pathway protein
I6J92_RS15680	COG2165	general secretion pathway protein
I6J92_RS15685	COG4795	General secretion pathway protein
I6J92_RS15690	COG3156	type II secretion system protein K
I6J92_RS15695	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J92_RS15700	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6J92_RS15705	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J92_RS15710	COG2193	ferroxidase activity
I6J92_RS15715	COG2906	2 iron, 2 sulfur cluster binding
I6J92_RS15720	COG3979	chitinase
I6J92_RS15760	COG2964	Protein conserved in bacteria
I6J92_RS15765	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J92_RS15775	COG1047	Peptidyl-prolyl cis-trans
I6J92_RS15780	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J92_RS15795	COG0488	(ABC) transporter
I6J92_RS15800	COG0429	hydrolase of the alpha beta-hydrolase fold
I6J92_RS15810	COG3954	Phosphoribulokinase
I6J92_RS15815	COG1765	OsmC-like protein
I6J92_RS15820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J92_RS15825	COG1289	transmembrane transporter activity
I6J92_RS15830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J92_RS15835	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J92_RS15840	COG2184	nucleotidyltransferase activity
I6J92_RS15850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J92_RS15860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J92_RS15865	COG2146	nitrite reductase [NAD(P)H] activity
I6J92_RS15870	COG2116	formate transmembrane transporter activity
I6J92_RS15885	COG0626	cystathionine gamma-synthase activity
I6J92_RS15900	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6J92_RS15905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6J92_RS15910	COG3457	Alanine racemase
I6J92_RS15920	COG2188	Transcriptional regulator
I6J92_RS15925	COG0180	Tryptophanyl-tRNA synthetase
I6J92_RS15935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J92_RS15940	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6J92_RS15945	COG3266	domain, Protein
I6J92_RS15960	COG4796	Type ii and iii secretion system protein
I6J92_RS15975	COG3166	PFAM Fimbrial assembly family protein
I6J92_RS15980	COG4972	Pilus assembly protein
I6J92_RS15985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J92_RS15990	COG0494	nUDIX hydrolase
I6J92_RS16000	COG1011	Hydrolase
I6J92_RS16005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J92_RS16015	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J92_RS16035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J92_RS16040	COG2183	response to ionizing radiation
I6J92_RS16045	COG1918	ferrous iron import across plasma membrane
I6J92_RS16050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J92_RS16065	COG0596	Alpha beta hydrolase
I6J92_RS16080	COG2610	gluconate transmembrane transporter activity
I6J92_RS16085	COG1640	4-alpha-glucanotransferase
I6J92_RS16090	COG0058	SHG alpha-glucan phosphorylase activity
I6J92_RS16105	COG1690	Belongs to the RtcB family
I6J92_RS16110	COG4650	regulator
I6J92_RS16115	COG1349	DNA-binding transcription factor activity
I6J92_RS16130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J92_RS16170	COG3188	usher protein
I6J92_RS16175	COG3121	Chaperone
I6J92_RS16185	COG0058	SHG alpha-glucan phosphorylase activity
I6J92_RS16210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J92_RS16215	COG2095	MarC family integral membrane protein
I6J92_RS16220	COG2610	gluconate transmembrane transporter activity
I6J92_RS16225	COG3265	gluconokinase activity
I6J92_RS16230	COG1609	Transcriptional regulator
I6J92_RS16235	COG1741	Belongs to the pirin family
I6J92_RS16240	COG0673	inositol 2-dehydrogenase activity
I6J92_RS16245	COG1247	-acetyltransferase
I6J92_RS16250	COG3157	Type VI secretion system effector, Hcp
I6J92_RS16270	COG0405	Gamma-glutamyltransferase
I6J92_RS16280	COG0584	glycerophosphoryl diester phosphodiesterase
I6J92_RS16305	COG0410	ABC transporter
I6J92_RS16310	COG0411	ABC transporter
I6J92_RS16315	COG4177	L-phenylalanine transmembrane transporter activity
I6J92_RS16320	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS16325	COG0683	leucine binding
I6J92_RS16330	COG0456	acetyltransferase
I6J92_RS16335	COG0683	leucine binding
I6J92_RS16360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J92_RS16365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J92_RS16370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J92_RS16375	COG2177	Part of the ABC transporter FtsEX involved in
I6J92_RS16380	COG2884	Cell division ATP-binding protein ftsE
I6J92_RS16385	COG0552	protein localization to endoplasmic reticulum
I6J92_RS16390	COG0742	ribosomal rna small subunit methyltransferase
I6J92_RS16395	COG3776	membrane
I6J92_RS16405	COG3714	YhhN family
I6J92_RS16420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6J92_RS16430	COG0477	Major facilitator Superfamily
I6J92_RS16435	COG0628	permease
I6J92_RS16440	COG2091	lysine biosynthetic process via aminoadipic acid
I6J92_RS16445	COG0747	negative chemotaxis
I6J92_RS16450	COG0601	transmembrane transport
I6J92_RS16455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J92_RS16460	COG0444	Belongs to the ABC transporter superfamily
I6J92_RS16475	COG2188	Transcriptional regulator
I6J92_RS16485	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J92_RS16490	COG3775	system Galactitol-specific IIC component
I6J92_RS16505	COG0191	fructose-bisphosphate aldolase activity
I6J92_RS16510	COG0842	Transport permease protein
I6J92_RS16515	COG1129	ABC transporter
I6J92_RS16515	COG0842	Transport permease protein
I6J92_RS16520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS16530	COG2081	HI0933 family
I6J92_RS16535	COG0306	phosphate transporter
I6J92_RS16545	COG0589	response to stress
I6J92_RS16550	COG3104	oligopeptide transport
I6J92_RS16560	COG0339	signal peptide processing
I6J92_RS16565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J92_RS16570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J92_RS16580	COG1393	Belongs to the ArsC family
I6J92_RS16590	COG3065	identical protein binding
I6J92_RS16595	COG2197	response regulator
I6J92_RS16600	COG3720	iron ion transport
I6J92_RS16605	COG4771	TonB-dependent receptor
I6J92_RS16620	COG3721	Heme iron utilization protein
I6J92_RS16630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS16640	COG1285	pathogenesis
I6J92_RS16655	COG3247	response to pH
I6J92_RS16660	COG2771	luxR family
I6J92_RS16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J92_RS16675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J92_RS16680	COG2207	Transcriptional regulator
I6J92_RS16690	COG0076	glutamate decarboxylase activity
I6J92_RS16695	COG1858	cytochrome C peroxidase
I6J92_RS16705	COG2197	response regulator
I6J92_RS16710	COG0583	DNA-binding transcription factor activity
I6J92_RS16715	COG1295	ribonuclease BN
I6J92_RS16720	COG0477	Major facilitator Superfamily
I6J92_RS16725	COG2982	Protein involved in outer membrane biogenesis
I6J92_RS16730	COG2200	EAL domain
I6J92_RS16735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS16740	COG0612	Peptidase, M16
I6J92_RS16750	COG2199	diguanylate cyclase activity
I6J92_RS16750	COG2200	EAL domain
I6J92_RS16755	COG0457	Tetratricopeptide repeat
I6J92_RS16755	COG3118	belongs to the thioredoxin family
I6J92_RS16760	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6J92_RS16765	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS16770	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS16795	COG2194	sulfuric ester hydrolase activity
I6J92_RS16805	COG0814	amino acid
I6J92_RS16810	COG4608	Belongs to the ABC transporter superfamily
I6J92_RS16815	COG0444	Belongs to the ABC transporter superfamily
I6J92_RS16820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J92_RS16825	COG0601	transmembrane transport
I6J92_RS16830	COG0747	negative chemotaxis
I6J92_RS16840	COG2194	sulfuric ester hydrolase activity
I6J92_RS16845	COG2223	nitrite transmembrane transporter activity
I6J92_RS16850	COG5571	outer membrane autotransporter
I6J92_RS16855	COG2818	Glycosylase
I6J92_RS16860	COG0456	acetyltransferase
I6J92_RS16865	COG0243	molybdopterin cofactor binding
I6J92_RS16870	COG2885	chlorophyll binding
I6J92_RS16885	COG2944	sequence-specific DNA binding
I6J92_RS16890	COG1278	Cold shock
I6J92_RS16915	COG3274	enterobacterial common antigen metabolic process
I6J92_RS16920	COG4682	membrane
I6J92_RS16925	COG4682	membrane
I6J92_RS16930	COG1070	Carbohydrate kinase
I6J92_RS16940	COG4213	ABC transporter substrate-binding protein
I6J92_RS16950	COG4214	carbohydrate transport
I6J92_RS16955	COG2207	Transcriptional regulator
I6J92_RS16955	COG1609	Transcriptional regulator
I6J92_RS16960	COG2992	FlgJ-related protein
I6J92_RS16965	COG0366	Alpha amylase catalytic
I6J92_RS16970	COG3977	Valine--pyruvate aminotransferase
I6J92_RS16975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J92_RS16980	COG1414	Transcriptional regulator
I6J92_RS16990	COG2731	YhcH YjgK YiaL family protein
I6J92_RS17000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6J92_RS17005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6J92_RS17010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6J92_RS17015	COG1070	Carbohydrate kinase
I6J92_RS17020	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6J92_RS17025	COG3623	hexulose-6-phosphate isomerase
I6J92_RS17030	COG0235	Class ii aldolase
I6J92_RS17035	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS17045	COG1454	alcohol dehydrogenase
I6J92_RS17050	COG3276	selenocysteine insertion sequence binding
I6J92_RS17060	COG0625	glutathione transferase activity
I6J92_RS17065	COG1566	PFAM secretion protein HlyD family protein
I6J92_RS17075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS17075	COG2213	PTS system mannitol-specific
I6J92_RS17085	COG3722	fumarate hydratase activity
I6J92_RS17105	COG5295	Hep Hag repeat protein
I6J92_RS17110	COG1620	l-lactate permease
I6J92_RS17115	COG2186	Transcriptional regulator
I6J92_RS17125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J92_RS17130	COG1045	serine acetyltransferase
I6J92_RS17145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J92_RS17150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J92_RS17160	COG4942	peptidase
I6J92_RS17165	COG2861	carbohydrate metabolic process
I6J92_RS17170	COG1216	Glycosyl transferase, family 2
I6J92_RS17180	COG0156	8-amino-7-oxononanoate synthase activity
I6J92_RS17190	COG0859	PFAM glycosyl transferase family 9
I6J92_RS17195	COG0859	PFAM glycosyl transferase family 9
I6J92_RS17200	COG3307	-O-antigen
I6J92_RS17205	COG1216	Glycosyl transferase, family 2
I6J92_RS17210	COG1442	glycosyl transferase family 8
I6J92_RS17215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J92_RS17230	COG0515	serine threonine protein kinase
I6J92_RS17235	COG0438	transferase activity, transferring glycosyl groups
I6J92_RS17240	COG0859	PFAM glycosyl transferase family 9
I6J92_RS17245	COG1519	Transferase
I6J92_RS17275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J92_RS17300	COG1561	YicC-like family, N-terminal region
I6J92_RS17425	COG3645	SOS response
I6J92_RS17430	COG2860	membrane
I6J92_RS17440	COG0194	GDP metabolic process
I6J92_RS17450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J92_RS17455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J92_RS17460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J92_RS17465	COG0786	glutamate:sodium symporter activity
I6J92_RS17470	COG2233	PERMEase
I6J92_RS17475	COG2982	Protein involved in outer membrane biogenesis
I6J92_RS17485	COG1940	carbohydrate kinase activity
I6J92_RS17490	COG0191	fructose-bisphosphate aldolase activity
I6J92_RS17500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS17500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS17505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS17510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS17510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS17510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS17515	COG3711	transcriptional antiterminator
I6J92_RS17520	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J92_RS17525	COG2211	Major facilitator Superfamily
I6J92_RS17535	COG0582	viral genome integration into host DNA
I6J92_RS17545	COG2194	sulfuric ester hydrolase activity
I6J92_RS17555	COG0582	viral genome integration into host DNA
I6J92_RS17565	COG0732	type I restriction modification DNA specificity domain
I6J92_RS17575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J92_RS17640	COG3436	PFAM IS66 Orf2 family protein
I6J92_RS17720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J92_RS17725	COG2801	Transposase and inactivated derivatives
I6J92_RS17730	COG2801	Transposase and inactivated derivatives
I6J92_RS17735	COG2963	transposase activity
I6J92_RS17780	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J92_RS17800	COG3596	GTP binding
I6J92_RS17805	COG2378	regulation of single-species biofilm formation
I6J92_RS17830	COG2003	Belongs to the UPF0758 family
I6J92_RS17870	COG0697	spore germination
I6J92_RS17875	COG1464	Belongs to the NlpA lipoprotein family
I6J92_RS17905	COG2252	PERMEase
I6J92_RS17915	COG2271	Major facilitator Superfamily
I6J92_RS17920	COG2271	Major facilitator Superfamily
I6J92_RS17925	COG3851	Histidine kinase
I6J92_RS17930	COG2197	response regulator
I6J92_RS17935	COG0440	acetolactate synthase activity
I6J92_RS17940	COG0028	Belongs to the TPP enzyme family
I6J92_RS17950	COG2814	Major facilitator Superfamily
I6J92_RS17955	COG0641	radical SAM
I6J92_RS17965	COG2149	membrane
I6J92_RS17970	COG3119	arylsulfatase activity
I6J92_RS17975	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J92_RS17980	COG2207	Transcriptional regulator
I6J92_RS18000	COG5645	(Lipo)protein
I6J92_RS18005	COG0823	Involved in the tonB-independent uptake of proteins
I6J92_RS18010	COG0644	oxidoreductase
I6J92_RS18015	COG2271	Major facilitator Superfamily
I6J92_RS18025	COG0800	Aldolase
I6J92_RS18030	COG3734	2-keto-3-deoxy-galactonokinase
I6J92_RS18035	COG2186	Transcriptional regulator
I6J92_RS18045	COG0561	phosphatase activity
I6J92_RS18050	COG3753	Protein conserved in bacteria
I6J92_RS18055	COG0187	DNA topoisomerase II activity
I6J92_RS18065	COG0592	DNA-directed DNA polymerase activity
I6J92_RS18115	COG0814	amino acid
I6J92_RS18130	COG2091	lysine biosynthetic process via aminoadipic acid
I6J92_RS18135	COG0431	NADPH-dependent FMN reductase
I6J92_RS18140	COG2252	PERMEase
I6J92_RS18145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J92_RS18155	COG0363	glucosamine-6-phosphate deaminase activity
I6J92_RS18160	COG2382	esterase
I6J92_RS18165	COG4580	involved in the transport of maltose and maltodextrins
I6J92_RS18170	COG2723	6-phospho-beta-galactosidase activity
I6J92_RS18175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS18175	COG1263	PTS System
I6J92_RS18175	COG2190	(PTS) system
I6J92_RS18180	COG3711	transcriptional antiterminator
I6J92_RS18185	COG0704	Plays a role in the regulation of phosphate uptake
I6J92_RS18190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J92_RS18195	COG0581	inorganic phosphate transmembrane transporter activity
I6J92_RS18200	COG0573	inorganic phosphate transmembrane transporter activity
I6J92_RS18205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J92_RS18260	COG3312	ion transport
I6J92_RS18275	COG0716	FMN binding
I6J92_RS18280	COG1522	sequence-specific DNA binding
I6J92_RS18310	COG1129	ABC transporter
I6J92_RS18315	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS18320	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS18325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS18330	COG1609	Transcriptional regulator
I6J92_RS18335	COG0477	Major facilitator Superfamily
I6J92_RS18340	COG2186	Transcriptional regulator
I6J92_RS18380	COG3085	chromosome segregation
I6J92_RS18385	COG0606	chelatase, subunit chli
I6J92_RS18405	COG3978	acetolactate synthase activity
I6J92_RS18410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J92_RS18415	COG0129	dihydroxy-acid dehydratase activity
I6J92_RS18420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J92_RS18425	COG0583	DNA-binding transcription factor activity
I6J92_RS18435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J92_RS18440	COG0210	DNA helicase
I6J92_RS18455	COG3118	belongs to the thioredoxin family
I6J92_RS18465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J92_RS18470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J92_RS18475	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6J92_RS18480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J92_RS18485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J92_RS18490	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J92_RS18495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J92_RS18500	COG0456	acetyltransferase
I6J92_RS18505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J92_RS18510	COG2244	polysaccharide biosynthetic process
I6J92_RS18530	COG1113	amino acid transport
I6J92_RS18555	COG0641	radical SAM
I6J92_RS18560	COG3119	arylsulfatase activity
I6J92_RS18565	COG3071	HemY protein
I6J92_RS18570	COG2959	enzyme of heme biosynthesis
I6J92_RS18575	COG1587	Uroporphyrinogen-III synthase
I6J92_RS18585	COG3072	Adenylate cyclase
I6J92_RS18600	COG5567	small periplasmic lipoprotein
I6J92_RS18610	COG3159	Protein conserved in bacteria
I6J92_RS18620	COG1011	Hydrolase
I6J92_RS18625	COG0210	DNA helicase
I6J92_RS18630	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6J92_RS18635	COG3698	Phosphodiester glycosidase
I6J92_RS18640	COG0598	Magnesium transport protein CorA
I6J92_RS18655	COG2962	Rard protein
I6J92_RS18660	COG2050	protein possibly involved in aromatic compounds catabolism
I6J92_RS18665	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6J92_RS18670	COG0514	ATP-dependent DNA helicase (RecQ)
I6J92_RS18675	COG1280	lysine exporter protein (LysE YggA)
I6J92_RS18680	COG1280	lysine exporter protein (LysE YggA)
I6J92_RS18685	COG2267	carboxylic ester hydrolase activity
I6J92_RS18690	COG0561	phosphatase activity
I6J92_RS18695	COG0697	spore germination
I6J92_RS18700	COG0583	DNA-binding transcription factor activity
I6J92_RS18715	COG3157	Type VI secretion system effector, Hcp
I6J92_RS18720	COG3157	Type VI secretion system effector, Hcp
I6J92_RS18730	COG1263	PTS System
I6J92_RS18730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS18730	COG2190	(PTS) system
I6J92_RS18735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J92_RS18740	COG1737	Transcriptional regulator
I6J92_RS18745	COG0583	DNA-binding transcription factor activity
I6J92_RS18750	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J92_RS18760	COG0549	Belongs to the carbamate kinase family
I6J92_RS18765	COG1304	FMN binding
I6J92_RS18770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J92_RS18780	COG1335	isochorismatase
I6J92_RS18785	COG0412	Dienelactone hydrolase
I6J92_RS18790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6J92_RS18810	COG0800	Aldolase
I6J92_RS18815	COG3734	2-keto-3-deoxy-galactonokinase
I6J92_RS18820	COG1414	Transcriptional regulator
I6J92_RS18825	COG1322	Protein conserved in bacteria
I6J92_RS18835	COG3165	ubiquinone biosynthetic process from chorismate
I6J92_RS18845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J92_RS18855	COG0805	protein transport
I6J92_RS18870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J92_RS18875	COG0543	2 iron, 2 sulfur cluster binding
I6J92_RS18885	COG1024	Enoyl-CoA hydratase
I6J92_RS18885	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J92_RS18895	COG1739	Uncharacterized protein family UPF0029
I6J92_RS18900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J92_RS18905	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6J92_RS18930	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6J92_RS18935	COG0746	molybdenum cofactor guanylyltransferase activity
I6J92_RS18940	COG3084	Protein conserved in bacteria
I6J92_RS18945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J92_RS18950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J92_RS18955	COG5339	Protein conserved in bacteria
I6J92_RS18960	COG0204	Acyl-transferase
I6J92_RS18965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J92_RS18965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J92_RS18980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J92_RS18990	COG2204	response regulator
I6J92_RS18995	COG3852	Histidine kinase
I6J92_RS19000	COG0174	glutamine synthetase
I6J92_RS19005	COG1217	gtp-binding protein TYPA
I6J92_RS19010	COG2188	Transcriptional regulator
I6J92_RS19020	COG2271	Major facilitator Superfamily
I6J92_RS19025	COG1349	DNA-binding transcription factor activity
I6J92_RS19030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J92_RS19035	COG2084	Dehydrogenase
I6J92_RS19040	COG3684	Belongs to the aldolase LacD family
I6J92_RS19045	COG1063	alcohol dehydrogenase
I6J92_RS19055	COG0477	Major facilitator Superfamily
I6J92_RS19065	COG1011	Hydrolase
I6J92_RS19080	COG0456	acetyltransferase
I6J92_RS19090	COG4680	protein conserved in bacteria
I6J92_RS19105	COG2864	formate dehydrogenase
I6J92_RS19110	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS19170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J92_RS19180	COG2258	MOSC domain
I6J92_RS19185	COG2205	protein histidine kinase activity
I6J92_RS19190	COG0745	RESPONSE REGULATOR receiver
I6J92_RS19195	COG3678	ATP-independent chaperone mediated protein folding
I6J92_RS19210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J92_RS19230	COG3152	Membrane
I6J92_RS19235	COG3691	Protein conserved in bacteria
I6J92_RS19240	COG0589	response to stress
I6J92_RS19250	COG1494	fructose-1,6-bisphosphatase
I6J92_RS19260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J92_RS19275	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J92_RS19290	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J92_RS19295	COG1609	Transcriptional regulator
I6J92_RS19300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J92_RS19310	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6J92_RS19320	COG0626	cystathionine gamma-synthase activity
I6J92_RS19325	COG0527	aspartate kinase activity
I6J92_RS19325	COG0460	homoserine dehydrogenase
I6J92_RS19335	COG0737	Belongs to the 5'-nucleotidase family
I6J92_RS19340	COG0737	Belongs to the 5'-nucleotidase family
I6J92_RS19350	COG0737	Belongs to the 5'-nucleotidase family
I6J92_RS19355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J92_RS19365	COG0697	spore germination
I6J92_RS19370	COG3738	Protein conserved in bacteria
I6J92_RS19375	COG0371	Dehydrogenase
I6J92_RS19380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J92_RS19385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J92_RS19385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS19385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS19390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS19395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS19400	COG1882	Formate acetyltransferase
I6J92_RS19405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J92_RS19410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J92_RS19415	COG2207	Transcriptional regulator
I6J92_RS19420	COG2194	sulfuric ester hydrolase activity
I6J92_RS19435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J92_RS19440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J92_RS19450	COG4948	Mandelate Racemase Muconate Lactonizing
I6J92_RS19455	COG2271	Major facilitator Superfamily
I6J92_RS19460	COG0583	DNA-binding transcription factor activity
I6J92_RS19470	COG1473	amidohydrolase
I6J92_RS19475	COG0477	Major facilitator Superfamily
I6J92_RS19495	COG4206	TonB-dependent receptor
I6J92_RS19525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J92_RS19530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J92_RS19530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J92_RS19565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J92_RS19570	COG0250	Participates in transcription elongation, termination and antitermination
I6J92_RS19605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J92_RS19615	COG2104	thiamine diphosphate biosynthetic process
I6J92_RS19620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J92_RS19630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J92_RS19655	COG3068	Protein conserved in bacteria
I6J92_RS19670	COG3678	ATP-independent chaperone mediated protein folding
I6J92_RS19675	COG4191	Histidine kinase
I6J92_RS19680	COG2204	response regulator
I6J92_RS19685	COG0151	Belongs to the GarS family
I6J92_RS19725	COG0456	acetyltransferase
I6J92_RS19735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J92_RS19740	COG2224	Isocitrate lyase
I6J92_RS19750	COG1414	Transcriptional regulator
I6J92_RS19755	COG0646	methionine synthase
I6J92_RS19755	COG1410	methionine synthase
I6J92_RS19770	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J92_RS19815	COG1187	pseudouridine synthase activity
I6J92_RS19825	COG0527	aspartate kinase activity
I6J92_RS19850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J92_RS19865	COG3833	ABC-type maltose transport systems, permease component
I6J92_RS19870	COG1175	transmembrane transport
I6J92_RS19875	COG2182	Extracellular solute-binding protein
I6J92_RS19880	COG3842	ATPase activity
I6J92_RS19910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J92_RS19920	COG0534	Mate efflux family protein
I6J92_RS19925	COG3237	CsbD-like
I6J92_RS19930	COG0735	belongs to the Fur family
I6J92_RS19985	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J92_RS19990	COG5532	Uncharacterized conserved protein (DUF2303)
I6J92_RS20030	COG1846	Transcriptional regulator
I6J92_RS20045	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6J92_RS20055	COG1403	HNH endonuclease
I6J92_RS20085	COG3772	lysozyme
I6J92_RS20110	COG4220	transposase activity
I6J92_RS20130	COG1030	water channel activity
I6J92_RS20180	COG1196	nuclear chromosome segregation
I6J92_RS20215	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6J92_RS20240	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6J92_RS20250	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6J92_RS20265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J92_RS20275	COG0604	alcohol dehydrogenase
I6J92_RS20280	COG1053	succinate dehydrogenase
I6J92_RS20285	COG0477	Major facilitator Superfamily
I6J92_RS20290	COG1024	Enoyl-CoA hydratase
I6J92_RS20300	COG1609	Transcriptional regulator
I6J92_RS20305	COG0305	Participates in initiation and elongation during chromosome replication
I6J92_RS20310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J92_RS20315	COG1448	Aminotransferase
I6J92_RS20320	COG0567	Dehydrogenase, E1 component
I6J92_RS20330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J92_RS20335	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J92_RS20340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J92_RS20345	COG0471	metal ion transport
I6J92_RS20350	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J92_RS20355	COG2204	response regulator
I6J92_RS20365	COG3700	Belongs to the class B bacterial acid phosphatase family
I6J92_RS20370	COG0432	Pfam Uncharacterised protein family UPF0047
I6J92_RS20375	COG2315	Protein conserved in bacteria
I6J92_RS20380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J92_RS20385	COG0629	single-stranded DNA binding
I6J92_RS20395	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6J92_RS20400	COG2207	Transcriptional regulator
I6J92_RS20405	COG0789	Transcriptional regulator
I6J92_RS20410	COG2252	PERMEase
I6J92_RS20415	COG0025	NhaP-type Na H and K H
I6J92_RS20420	COG0583	DNA-binding transcription factor activity
I6J92_RS20425	COG1380	Effector of murein hydrolase LrgA
I6J92_RS20430	COG1346	cytolysis
I6J92_RS20440	COG3162	membrane
I6J92_RS20445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J92_RS20455	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J92_RS20460	COG0437	4 iron, 4 sulfur cluster binding
I6J92_RS20465	COG3301	Polysulphide reductase, NrfD
I6J92_RS20470	COG1138	Cytochrome C-type biogenesis protein
I6J92_RS20475	COG3088	subunit of a heme lyase
I6J92_RS20480	COG4235	cytochrome complex assembly
I6J92_RS20485	COG1301	dicarboxylic acid transport
I6J92_RS20490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6J92_RS20495	COG4608	Belongs to the ABC transporter superfamily
I6J92_RS20500	COG0444	Belongs to the ABC transporter superfamily
I6J92_RS20505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J92_RS20510	COG0601	transmembrane transport
I6J92_RS20525	COG1538	Outer membrane efflux protein
I6J92_RS20530	COG1289	transmembrane transporter activity
I6J92_RS20535	COG1566	PFAM secretion protein HlyD family protein
I6J92_RS20545	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J92_RS20550	COG1940	carbohydrate kinase activity
I6J92_RS20555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J92_RS20560	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS20565	COG1129	ABC transporter
I6J92_RS20570	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS20575	COG1737	Transcriptional regulator
I6J92_RS20580	COG0698	ribose 5-phosphate isomerase
I6J92_RS20590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J92_RS20595	COG0456	acetyltransferase
I6J92_RS20600	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6J92_RS20605	COG3454	Phosphonate metabolism
I6J92_RS20610	COG4778	phosphonate C-P lyase system protein PhnL
I6J92_RS20615	COG4107	phosphonate C-P lyase system protein PhnK
I6J92_RS20620	COG3627	carbon phosphorus lyase activity
I6J92_RS20625	COG3626	phosphonate metabolism
I6J92_RS20630	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6J92_RS20635	COG3624	Phosphonate C-P lyase system protein PhnG
I6J92_RS20640	COG2188	Transcriptional regulator
I6J92_RS20645	COG3639	organic phosphonate transmembrane transporter activity
I6J92_RS20650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6J92_RS20660	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6J92_RS20665	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J92_RS20680	COG0477	Major facilitator Superfamily
I6J92_RS20690	COG0642	Histidine kinase
I6J92_RS20695	COG0745	RESPONSE REGULATOR receiver
I6J92_RS20700	COG2194	sulfuric ester hydrolase activity
I6J92_RS20705	COG0531	amino acid
I6J92_RS20710	COG2207	Transcriptional regulator
I6J92_RS20715	COG1982	Orn Lys Arg decarboxylase major
I6J92_RS20720	COG2169	Transcriptional regulator
I6J92_RS20725	COG1486	melibiose metabolic process
I6J92_RS20730	COG3647	Membrane
I6J92_RS20735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J92_RS20735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J92_RS20740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J92_RS20745	COG4565	transcriptional regulatory protein
I6J92_RS20750	COG3290	protein histidine kinase activity
I6J92_RS20755	COG3592	Divergent 4Fe-4S mono-cluster
I6J92_RS20760	COG2388	GCN5-related N-acetyl-transferase
I6J92_RS20775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J92_RS20780	COG3104	oligopeptide transport
I6J92_RS20785	COG1982	Orn Lys Arg decarboxylase major
I6J92_RS20790	COG0531	amino acid
I6J92_RS20795	COG3710	Transcriptional regulator
I6J92_RS20805	COG1309	transcriptional regulator
I6J92_RS20810	COG4232	protein-disulfide reductase activity
I6J92_RS20820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J92_RS20825	COG1027	Aspartate ammonia-lyase
I6J92_RS20830	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6J92_RS20835	COG0531	amino acid
I6J92_RS20860	COG1509	lysine 2,3-aminomutase activity
I6J92_RS20870	COG5510	response to toxic substance
I6J92_RS20875	COG5510	response to toxic substance
I6J92_RS20880	COG2076	Multidrug Resistance protein
I6J92_RS20885	COG3040	lipid binding
I6J92_RS20890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J92_RS20905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J92_RS20910	COG1053	succinate dehydrogenase
I6J92_RS20920	COG0531	amino acid
I6J92_RS20925	COG1511	domain protein
I6J92_RS20925	COG3264	Mechanosensitive ion channel
I6J92_RS20965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J92_RS20970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J92_RS20970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J92_RS20975	COG0802	atpase or kinase
I6J92_RS20980	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J92_RS21000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J92_RS21005	COG0330	HflC and HflK could
I6J92_RS21010	COG0330	HflC and HflK could
I6J92_RS21015	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6J92_RS21030	COG0557	exoribonuclease II activity
I6J92_RS21035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J92_RS21040	COG3789	protein conserved in bacteria
I6J92_RS21045	COG1842	Phage shock protein A
I6J92_RS21055	COG3766	membrane
I6J92_RS21060	COG5463	Belongs to the UPF0441 family
I6J92_RS21065	COG0754	glutathionylspermidine amidase activity
I6J92_RS21070	COG1960	acyl-CoA dehydrogenase activity
I6J92_RS21080	COG3650	response to hydrogen peroxide
I6J92_RS21085	COG1073	alpha beta
I6J92_RS21100	COG3037	sugar-specific permease SgaT UlaA
I6J92_RS21105	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J92_RS21145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J92_RS21165	COG2271	Major facilitator Superfamily
I6J92_RS21175	COG4670	ketone body catabolic process
I6J92_RS21180	COG1024	Enoyl-CoA hydratase
I6J92_RS21195	COG1309	transcriptional regulator
I6J92_RS21200	COG3061	Opacity-associated protein A
I6J92_RS21205	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J92_RS21210	COG1113	amino acid transport
I6J92_RS21220	COG0697	spore germination
I6J92_RS21225	COG0702	epimerase
I6J92_RS21230	COG1733	regulation of RNA biosynthetic process
I6J92_RS21235	COG0737	Belongs to the 5'-nucleotidase family
I6J92_RS21240	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6J92_RS21245	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6J92_RS21255	COG1253	flavin adenine dinucleotide binding
I6J92_RS21265	COG0729	surface antigen
I6J92_RS21270	COG2911	Protein conserved in bacteria
I6J92_RS21275	COG2105	PFAM AIG2 family protein
I6J92_RS21280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J92_RS21285	COG1879	ABC-type sugar transport system periplasmic component
I6J92_RS21290	COG1129	ABC transporter
I6J92_RS21295	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS21300	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J92_RS21310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J92_RS21315	COG3028	Belongs to the UPF0307 family
I6J92_RS21320	COG0312	modulator of DNA gyrase
I6J92_RS21325	COG3783	Cytochrome b(562)
I6J92_RS21330	COG0602	queuosine metabolic process
I6J92_RS21335	COG1328	CTP reductase activity
I6J92_RS21340	COG0366	Alpha amylase catalytic
I6J92_RS21345	COG1263	PTS System
I6J92_RS21345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J92_RS21350	COG1609	Transcriptional regulator
I6J92_RS21360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J92_RS21365	COG0251	oxidation-reduction process
I6J92_RS21385	COG1438	arginine binding
I6J92_RS21390	COG1288	antiporter activity
I6J92_RS21395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J92_RS21400	COG0549	Belongs to the carbamate kinase family
I6J92_RS21410	COG2731	YhcH YjgK YiaL family protein
I6J92_RS21415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J92_RS21420	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6J92_RS21425	COG0456	acetyltransferase
I6J92_RS21435	COG0525	valine-tRNA ligase activity
I6J92_RS21440	COG2927	DNA polymerase III (CHI subunit)
I6J92_RS21450	COG0795	lipopolysaccharide-transporting ATPase activity
I6J92_RS21455	COG0795	lipopolysaccharide-transporting ATPase activity
I6J92_RS21460	COG0433	COG0433 Predicted ATPase
I6J92_RS21465	COG1609	Transcriptional regulator
I6J92_RS21470	COG2610	gluconate transmembrane transporter activity
I6J92_RS21475	COG1028	Short-chain dehydrogenase reductase Sdr
I6J92_RS21480	COG1063	alcohol dehydrogenase
I6J92_RS21485	COG3265	gluconokinase activity
I6J92_RS21490	COG1064	alcohol dehydrogenase
I6J92_RS21500	COG0582	viral genome integration into host DNA
I6J92_RS21505	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J92_RS21505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J92_RS21510	COG2194	sulfuric ester hydrolase activity
I6J92_RS21640	COG2259	Doxx family
I6J92_RS21645	COG1304	FMN binding
I6J92_RS21655	COG1309	transcriptional regulator
I6J92_RS21660	COG4372	Transposase
I6J92_RS21665	COG3436	PFAM IS66 Orf2 family protein
I6J92_RS21720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J92_RS21725	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6J92_RS21730	COG0745	RESPONSE REGULATOR receiver
I6J92_RS21735	COG5002	protein histidine kinase activity
I6J92_RS21830	COG2610	gluconate transmembrane transporter activity
I6J92_RS21835	COG0583	DNA-binding transcription factor activity
I6J92_RS21845	COG2076	Multidrug Resistance protein
I6J92_RS21860	COG4869	propanediol catabolic process
I6J92_RS21870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J92_RS21875	COG1882	Formate acetyltransferase
I6J92_RS21880	COG1454	alcohol dehydrogenase
I6J92_RS21880	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS21890	COG1012	belongs to the aldehyde dehydrogenase family
I6J92_RS21890	COG1454	alcohol dehydrogenase
I6J92_RS21930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J92_RS21935	COG1757	Na H antiporter
I6J92_RS21970	COG3596	GTP binding
I6J92_RS21975	COG2378	regulation of single-species biofilm formation
I6J92_RS22000	COG2003	Belongs to the UPF0758 family
I6J92_RS22030	COG2390	Transcriptional regulator
I6J92_RS22035	COG2610	gluconate transmembrane transporter activity
I6J92_RS22040	COG0129	dihydroxy-acid dehydratase activity
I6J92_RS22045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J92_RS22050	COG1414	Transcriptional regulator
I6J92_RS22055	COG1349	DNA-binding transcription factor activity
I6J92_RS22060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J92_RS22065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS22070	COG0434	BtpA family
I6J92_RS22075	COG3775	system Galactitol-specific IIC component
I6J92_RS22080	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J92_RS22085	COG1363	Peptidase, m42
I6J92_RS22100	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J92_RS22105	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J92_RS22110	COG3153	acetyltransferase
I6J92_RS22135	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6J92_RS22140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6J92_RS22145	COG0582	viral genome integration into host DNA
I6J92_RS22150	COG4974	Belongs to the 'phage' integrase family
I6J92_RS22155	COG3539	Fimbrial protein
I6J92_RS22160	COG3539	Fimbrial protein
I6J92_RS22165	COG3121	Chaperone
I6J92_RS22170	COG3188	usher protein
I6J92_RS22175	COG3539	Fimbrial protein
I6J92_RS22180	COG3539	Fimbrial protein
I6J92_RS22185	COG3539	Fimbrial protein
I6J92_RS22190	COG2610	gluconate transmembrane transporter activity
I6J92_RS22200	COG0246	Mannitol dehydrogenase
I6J92_RS22205	COG2186	Transcriptional regulator
I6J92_RS22220	COG0583	DNA-binding transcription factor activity
I6J92_RS22225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J92_RS22230	COG0700	Nucleoside recognition
I6J92_RS22235	COG3366	ferrous iron transmembrane transporter activity
I6J92_RS22245	COG0477	Major facilitator Superfamily
I6J92_RS22260	COG1924	4 iron, 4 sulfur cluster binding
I6J92_RS22265	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6J92_RS22270	COG2733	membrane
I6J92_RS22280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J92_RS22295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J92_RS22300	COG0732	type I restriction modification DNA specificity domain
I6J92_RS22310	COG1715	Restriction endonuclease
I6J92_RS22325	COG0523	cobalamin synthesis protein
I6J92_RS22330	COG2879	small protein
I6J92_RS22335	COG1966	Carbon starvation protein
I6J92_RS22340	COG0840	transmembrane signaling receptor activity
I6J92_RS22345	COG2271	Major facilitator Superfamily
I6J92_RS22350	COG1802	Transcriptional regulator
I6J92_RS22355	COG1063	alcohol dehydrogenase
I6J92_RS22370	COG1484	DNA-dependent DNA replication
I6J92_RS22385	COG2966	Psort location CytoplasmicMembrane, score
I6J92_RS22390	COG2197	response regulator
I6J92_RS22395	COG2197	response regulator
I6J92_RS22400	COG4114	ferric iron reductase
I6J92_RS22430	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6J92_RS22435	COG0456	acetyltransferase
I6J92_RS22440	COG1011	Hydrolase
I6J92_RS22465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J92_RS22480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J92_RS22485	COG4197	protein conserved in bacteria, prophage-related
I6J92_RS22500	COG1846	Transcriptional regulator
I6J92_RS22510	COG4725	Belongs to the MT-A70-like family
I6J92_RS22530	COG1403	HNH endonuclease
I6J92_RS22575	COG4626	Terminase
I6J92_RS22575	COG1802	Transcriptional regulator
I6J92_RS22585	COG4695	Portal protein
I6J92_RS22630	COG4386	tail sheath protein
I6J92_RS22650	COG4228	DNA circulation
I6J92_RS22670	COG3299	homolog of phage Mu protein gp47
I6J92_RS22675	COG3778	Protein conserved in bacteria
I6J92_RS22690	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J92_RS22700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J92_RS22705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J92_RS22720	COG2823	Periplasmic or secreted lipoprotein
I6J92_RS22730	COG4667	esterase of the alpha-beta hydrolase superfamily
I6J92_RS22735	COG0084	hydrolase, TatD family'
I6J92_RS22740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J92_RS22745	COG1328	CTP reductase activity
I6J92_RS22770	COG3550	peptidyl-serine autophosphorylation
I6J92_RS22780	COG3726	membrane protein affecting hemolysin expression
I6J92_RS22785	COG0560	Phosphoserine phosphatase
I6J92_RS22790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J92_RS22795	COG3172	ATPase kinase involved in NAD metabolism
I6J92_RS22795	COG1056	cytidyltransferase-related domain
I6J92_RS22800	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6J92_RS22810	COG0488	(ABC) transporter
I6J92_RS22815	COG0741	lytic transglycosylase activity
I6J92_RS22835	COG2207	Transcriptional regulator
I6J92_RS22835	COG3708	Transcriptional regulator
I6J92_RS22840	COG3045	CreA protein
I6J92_RS22845	COG0745	RESPONSE REGULATOR receiver
I6J92_RS22850	COG2205	protein histidine kinase activity
I6J92_RS22855	COG4452	Inner membrane protein CreD
I6J92_RS22860	COG0745	RESPONSE REGULATOR receiver
I6J92_RS22870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6J92_RS22880	COG0460	homoserine dehydrogenase
I6J92_RS22880	COG0527	aspartate kinase activity
I6J92_RS22890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J92_RS22905	COG1115	amino acid carrier protein
I6J92_RS22915	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J92_RS22920	COG1584	GPR1 FUN34 yaaH family protein
I6J92_RS22925	COG4735	regulation of single-species biofilm formation
I6J92_RS22955	COG3119	arylsulfatase activity
I6J92_RS22970	COG0583	DNA-binding transcription factor activity
I6J92_RS22985	COG0196	riboflavin kinase activity
I6J92_RS23000	COG1047	Peptidyl-prolyl cis-trans
I6J92_RS23025	COG0505	Belongs to the CarA family
I6J92_RS23030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J92_RS23080	COG0644	oxidoreductase
I6J92_RS23085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J92_RS23090	COG2271	Major facilitator Superfamily
I6J92_RS23105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J92_RS23135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J92_RS23140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J92_RS23150	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6J92_RS23155	COG0564	pseudouridine synthase activity
I6J92_RS23165	COG0417	DNA replication proofreading
I6J92_RS23170	COG0235	Class ii aldolase
I6J92_RS23185	COG4977	sequence-specific DNA binding
I6J92_RS23190	COG0586	Pfam SNARE associated Golgi protein
I6J92_RS23200	COG1178	ABC-type Fe3 transport system permease component
I6J92_RS23205	COG4143	(ABC) transporter
I6J92_RS23245	COG0583	DNA-binding transcription factor activity
I6J92_RS23255	COG0028	Belongs to the TPP enzyme family
I6J92_RS23260	COG0440	acetolactate synthase activity
I6J92_RS23270	COG1609	Transcriptional regulator
I6J92_RS23285	COG3116	cell division
I6J92_RS23290	COG0768	penicillin binding
I6J92_RS23295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J92_RS23300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J92_RS23315	COG0772	Belongs to the SEDS family
I6J92_RS23330	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J92_RS23335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J92_RS23340	COG0849	cell division
I6J92_RS23345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J92_RS23365	COG0494	nUDIX hydrolase
I6J92_RS23380	COG0237	dephospho-CoA kinase activity
I6J92_RS23395	COG1459	type II secretion system
I6J92_RS23400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J92_RS23405	COG4969	Belongs to the N-Me-Phe pilin family
I6J92_RS23410	COG0157	Belongs to the NadC ModD family
I6J92_RS23415	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J92_RS23420	COG3725	Membrane protein required for beta-lactamase induction
I6J92_RS23425	COG1113	amino acid transport
I6J92_RS23430	COG3157	Type VI secretion system effector, Hcp
I6J92_RS23460	COG2186	Transcriptional regulator
I6J92_RS23465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J92_RS23470	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J92_RS23475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J92_RS23480	COG3064	Membrane
I6J92_RS23485	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6J92_RS23510	COG2132	Multicopper oxidase
I6J92_RS23515	COG4993	Dehydrogenase
I6J92_RS23520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J92_RS23525	COG0288	reversible hydration of carbon dioxide
I6J92_RS23530	COG1131	(ABC) transporter
I6J92_RS23535	COG0842	Transport permease protein
I6J92_RS23540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J92_RS23545	COG0726	polysaccharide deacetylase
I6J92_RS23555	COG5464	transposase or invertase
I6J92_RS23560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J92_RS23570	COG3539	Fimbrial protein
I6J92_RS23575	COG3539	Fimbrial protein
I6J92_RS23580	COG3539	Fimbrial protein
I6J92_RS23585	COG3539	Fimbrial protein
I6J92_RS23590	COG3188	usher protein
I6J92_RS23595	COG3121	Chaperone
I6J92_RS23600	COG3539	Fimbrial protein
I6J92_RS23605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J92_RS23610	COG0617	tRNA 3'-terminal CCA addition
I6J92_RS23615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J92_RS23620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J92_RS23630	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6J92_RS23635	COG1643	Atp-dependent helicase
I6J92_RS23640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J92_RS23645	COG4774	siderophore transport
I6J92_RS23650	COG1120	ATPase activity
I6J92_RS23655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J92_RS23660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J92_RS23685	COG2860	membrane
I6J92_RS23690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J92_RS23705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J92_RS23710	COG3835	regulator
I6J92_RS23730	COG0024	Methionine aminopeptidase
I6J92_RS23755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J92_RS23760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J92_RS23765	COG0575	Belongs to the CDS family
I6J92_RS23770	COG0750	zinc metalloprotease
I6J92_RS23780	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6J92_RS23785	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J92_RS23810	COG0587	DNA-directed DNA polymerase activity
I6J92_RS23820	COG1982	Orn Lys Arg decarboxylase major
I6J92_RS23825	COG0346	lactoylglutathione lyase activity
I6J92_RS23830	COG0037	tRNA processing
I6J92_RS23835	COG4568	rho-dependent transcription termination
I6J92_RS23845	COG4681	YaeQ
I6J92_RS23850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J92_RS23855	COG3015	lipoprotein NlpE involved in copper resistance
I6J92_RS23860	COG0791	NLP P60 protein
I6J92_RS23870	COG1720	tRNA m6t6A37 methyltransferase activity
I6J92_RS23880	COG1464	Belongs to the NlpA lipoprotein family
I6J92_RS23885	COG2011	ABC-type metal ion transport system permease component
I6J92_RS23895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J92_RS23930	COG0656	L-ascorbic acid biosynthetic process
I6J92_RS23935	COG0583	DNA-binding transcription factor activity
I6J92_RS23945	COG2226	methyltransferase
I6J92_RS23950	COG0741	lytic transglycosylase activity
I6J92_RS23950	COG1388	LysM domain
I6J92_RS23960	COG2226	methyltransferase
I6J92_RS23970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J92_RS24065	COG3501	Rhs element vgr protein
I6J92_RS24105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J92_RS24115	COG1960	acyl-CoA dehydrogenase activity
I6J92_RS24125	COG0121	glutamine amidotransferase
I6J92_RS24130	COG3034	peptidoglycan biosynthetic process
I6J92_RS24135	COG0791	NLP P60 protein
I6J92_RS24165	COG0454	-acetyltransferase
I6J92_RS24170	COG1690	Belongs to the RtcB family
I6J92_RS24175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J92_RS24180	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J92_RS24200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6J92_RS24285	COG0582	viral genome integration into host DNA
I6J92_RS24310	COG3477	response to acidic pH
I6J92_RS24320	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6J92_RS24375	COG1902	pentaerythritol trinitrate reductase activity
I6J92_RS24380	COG1073	alpha beta
I6J92_RS24385	COG0583	DNA-binding transcription factor activity
I6J92_RS24395	COG0667	Aldo Keto reductase
I6J92_RS24400	COG0656	L-ascorbic acid biosynthetic process
I6J92_RS24405	COG1388	LysM domain
I6J92_RS24410	COG2207	Transcriptional regulator
I6J92_RS24410	COG3708	Transcriptional regulator
I6J92_RS24415	COG0656	L-ascorbic acid biosynthetic process
I6J92_RS24420	COG3059	membrane
I6J92_RS24430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J92_RS24435	COG2207	Transcriptional regulator
I6J92_RS24440	COG0247	lactate metabolic process
I6J92_RS24445	COG1139	Iron-sulfur cluster binding protein
I6J92_RS24450	COG1556	Lactate utilization protein
I6J92_RS24460	COG3468	outer membrane autotransporter barrel domain protein
I6J92_RS24475	COG2771	luxR family
I6J92_RS24475	COG2200	EAL domain
I6J92_RS24480	COG0582	viral genome integration into host DNA
I6J92_RS24485	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6J92_RS24500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J92_RS24505	COG2200	EAL domain
I6J92_RS24505	COG2771	luxR family
I6J92_RS24510	COG0583	DNA-binding transcription factor activity
I6J92_RS24520	COG0666	response to abiotic stimulus
I6J92_RS24530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J92_RS24535	COG1304	FMN binding
I6J92_RS24540	COG0549	Belongs to the carbamate kinase family
I6J92_RS24545	COG0402	S-adenosylhomocysteine deaminase activity
I6J92_RS24550	COG1064	alcohol dehydrogenase
I6J92_RS24560	COG1280	lysine exporter protein (LysE YggA)
I6J92_RS24570	COG3829	transcription factor binding
I6J92_RS24575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6J92_RS24580	COG0372	Belongs to the citrate synthase family
I6J92_RS24585	COG2079	MmgE PrpD family protein
I6J92_RS24590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J92_RS24595	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J92_RS24600	COG0402	S-adenosylhomocysteine deaminase activity
I6J92_RS24605	COG0110	maltose O-acetyltransferase activity
I6J92_RS24610	COG2223	nitrite transmembrane transporter activity
I6J92_RS24615	COG3250	beta-galactosidase activity
I6J92_RS24620	COG1609	Transcriptional regulator
I6J92_RS24630	COG3122	Protein conserved in bacteria
I6J92_RS24660	COG1215	transferase activity, transferring glycosyl groups
I6J92_RS24665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J92_RS24670	COG4521	taurine ABC transporter
I6J92_RS24680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J92_RS24685	COG2175	clavaminate synthase activity
I6J92_RS24690	COG0113	porphobilinogen synthase activity
I6J92_RS24695	COG3468	outer membrane autotransporter barrel domain protein
I6J92_RS24700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J92_RS24705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J92_RS24710	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J92_RS24730	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J92_RS24745	COG1785	Belongs to the alkaline phosphatase family
I6J92_RS24755	COG3706	GGDEF domain
I6J92_RS24760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J92_RS24780	COG4126	flavin adenine dinucleotide binding
I6J92_RS24805	COG1940	carbohydrate kinase activity
I6J92_RS24810	COG2814	Major facilitator Superfamily
I6J92_RS24815	COG0419	ATPase involved in DNA repair
I6J92_RS24820	COG0420	3'-5' exonuclease activity
I6J92_RS24825	COG0745	RESPONSE REGULATOR receiver
I6J92_RS24830	COG5002	protein histidine kinase activity
I6J92_RS24835	COG1114	Component of the transport system for branched-chain amino acids
I6J92_RS24840	COG1113	amino acid transport
I6J92_RS24845	COG0366	Alpha amylase catalytic
I6J92_RS24865	COG1862	Preprotein translocase
I6J92_RS24870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J92_RS24875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J92_RS24880	COG1403	HNH endonuclease
I6J92_RS24885	COG3248	Nucleoside-binding outer membrane protein
I6J92_RS24890	COG4238	major outer membrane lipoprotein
I6J92_RS24900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J92_RS24900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J92_RS24915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J92_RS24920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J92_RS24925	COG0667	Aldo Keto reductase
I6J92_RS24935	COG0142	geranyltranstransferase activity
I6J92_RS24950	COG0693	protein deglycase activity
I6J92_RS24955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J92_RS24965	COG2814	Major facilitator Superfamily
I6J92_RS24975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J92_RS24980	COG1845	cytochrome c oxidase, subunit III
I6J92_RS24985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J92_RS24990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor