locus-tag	class	description
I6K11_RS00070	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K11_RS00075	COG0672	)-iron permease
I6K11_RS00095	COG0577	efflux transmembrane transporter activity
I6K11_RS00095	COG1136	(ABC) transporter
I6K11_RS00100	COG0577	efflux transmembrane transporter activity
I6K11_RS00100	COG1136	(ABC) transporter
I6K11_RS00130	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS00135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K11_RS00140	COG1902	pentaerythritol trinitrate reductase activity
I6K11_RS00150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K11_RS00175	COG3436	PFAM IS66 Orf2 family protein
I6K11_RS00205	COG4771	TonB-dependent receptor
I6K11_RS00400	COG1475	DNA binding
I6K11_RS00630	COG3436	PFAM IS66 Orf2 family protein
I6K11_RS00635	COG4372	Transposase
I6K11_RS00675	COG2235	arginine
I6K11_RS00690	COG1288	antiporter activity
I6K11_RS00695	COG1438	arginine binding
I6K11_RS00710	COG3436	PFAM IS66 Orf2 family protein
I6K11_RS00855	COG1660	Displays ATPase and GTPase activities
I6K11_RS00925	COG3173	Aminoglycoside phosphotransferase
I6K11_RS00945	COG0640	Transcriptional regulator
I6K11_RS00990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K11_RS01000	COG0672	)-iron permease
I6K11_RS01020	COG1136	(ABC) transporter
I6K11_RS01020	COG0577	efflux transmembrane transporter activity
I6K11_RS01025	COG1136	(ABC) transporter
I6K11_RS01025	COG0577	efflux transmembrane transporter activity
I6K11_RS01035	COG1554	hydrolase, family 65, central catalytic
I6K11_RS01040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K11_RS01045	COG3842	ATPase activity
I6K11_RS01055	COG1609	Transcriptional regulator
I6K11_RS01060	COG3106	COG3106 Predicted ATPase
I6K11_RS01070	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6K11_RS01075	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K11_RS01080	COG4948	Mandelate Racemase Muconate Lactonizing
I6K11_RS01085	COG2866	Carboxypeptidase
I6K11_RS01090	COG0702	epimerase
I6K11_RS01095	COG1073	alpha beta
I6K11_RS01100	COG0583	DNA-binding transcription factor activity
I6K11_RS01105	COG4166	transmembrane transport
I6K11_RS01110	COG0668	transmembrane transport
I6K11_RS01115	COG3182	Iron-regulated membrane protein
I6K11_RS01120	COG0589	response to stress
I6K11_RS01125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K11_RS01130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K11_RS01135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K11_RS01140	COG1473	amidohydrolase
I6K11_RS01145	COG1473	amidohydrolase
I6K11_RS01150	COG0583	DNA-binding transcription factor activity
I6K11_RS01155	COG2207	Transcriptional regulator
I6K11_RS01170	COG2840	Smr protein MutS2
I6K11_RS01175	COG3706	GGDEF domain
I6K11_RS01195	COG0513	Belongs to the DEAD box helicase family
I6K11_RS01205	COG0582	viral genome integration into host DNA
I6K11_RS01225	COG3723	Recombinational DNA repair protein, rece pathway
I6K11_RS01230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS01280	COG3756	Protein conserved in bacteria
I6K11_RS01285	COG1484	DNA-dependent DNA replication
I6K11_RS01290	COG1846	Transcriptional regulator
I6K11_RS01360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K11_RS01365	COG1475	DNA binding
I6K11_RS01450	COG1196	nuclear chromosome segregation
I6K11_RS01490	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS01535	COG0246	Mannitol dehydrogenase
I6K11_RS01545	COG1802	Transcriptional regulator
I6K11_RS01550	COG4221	oxidoreductase activity
I6K11_RS01555	COG0339	signal peptide processing
I6K11_RS01560	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K11_RS01565	COG3706	GGDEF domain
I6K11_RS01575	COG2814	Major facilitator Superfamily
I6K11_RS01580	COG0697	spore germination
I6K11_RS01585	COG2188	Transcriptional regulator
I6K11_RS01595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K11_RS01600	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K11_RS01610	COG2723	6-phospho-beta-galactosidase activity
I6K11_RS01620	COG4977	sequence-specific DNA binding
I6K11_RS01625	COG1846	Transcriptional regulator
I6K11_RS01645	COG0583	DNA-binding transcription factor activity
I6K11_RS01650	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS01655	COG2066	Belongs to the glutaminase family
I6K11_RS01665	COG2199	diguanylate cyclase activity
I6K11_RS01675	COG3781	membrane
I6K11_RS01715	COG3210	domain, Protein
I6K11_RS01715	COG2911	Protein conserved in bacteria
I6K11_RS01720	COG1396	sequence-specific DNA binding
I6K11_RS01725	COG3550	peptidyl-serine autophosphorylation
I6K11_RS01755	COG0656	L-ascorbic acid biosynthetic process
I6K11_RS01765	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K11_RS01770	COG0667	Aldo Keto reductase
I6K11_RS01790	COG3539	Fimbrial protein
I6K11_RS01800	COG3188	usher protein
I6K11_RS01805	COG3539	Fimbrial protein
I6K11_RS01810	COG3539	Fimbrial protein
I6K11_RS01815	COG3539	Fimbrial protein
I6K11_RS01820	COG0243	molybdopterin cofactor binding
I6K11_RS01835	COG3119	arylsulfatase activity
I6K11_RS01840	COG0641	radical SAM
I6K11_RS01850	COG4178	(ABC) transporter
I6K11_RS01855	COG4771	TonB-dependent receptor
I6K11_RS01860	COG0612	Peptidase, M16
I6K11_RS01865	COG0076	glutamate decarboxylase activity
I6K11_RS01870	COG0531	amino acid
I6K11_RS01875	COG1649	PFAM Uncharacterised BCR, COG1649
I6K11_RS01890	COG2199	diguanylate cyclase activity
I6K11_RS01890	COG2200	EAL domain
I6K11_RS01890	COG2202	Pas domain
I6K11_RS01895	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6K11_RS01900	COG0747	negative chemotaxis
I6K11_RS01905	COG0601	transmembrane transport
I6K11_RS01910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K11_RS01915	COG0444	Belongs to the ABC transporter superfamily
I6K11_RS01920	COG4608	Belongs to the ABC transporter superfamily
I6K11_RS01925	COG1764	response to oxidative stress
I6K11_RS01945	COG1064	alcohol dehydrogenase
I6K11_RS01950	COG3093	addiction module antidote protein HigA
I6K11_RS01960	COG2864	formate dehydrogenase
I6K11_RS01965	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS01975	COG0697	spore germination
I6K11_RS01980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K11_RS02000	COG2223	nitrite transmembrane transporter activity
I6K11_RS02005	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K11_RS02010	COG1140	nitrate reductase beta subunit
I6K11_RS02015	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K11_RS02020	COG2181	nitrate reductase activity
I6K11_RS02025	COG0384	phenazine biosynthesis protein PhzF
I6K11_RS02030	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K11_RS02035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K11_RS02045	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K11_RS02050	COG3706	GGDEF domain
I6K11_RS02050	COG4251	negative regulation of phosphorylation
I6K11_RS02050	COG2203	Gaf domain
I6K11_RS02050	COG5001	Diguanylate cyclase
I6K11_RS02065	COG3209	COG3209 Rhs family protein
I6K11_RS02080	COG0625	glutathione transferase activity
I6K11_RS02085	COG1113	amino acid transport
I6K11_RS02090	COG3391	amine dehydrogenase activity
I6K11_RS02095	COG4772	TonB-dependent receptor
I6K11_RS02100	COG1802	Transcriptional regulator
I6K11_RS02105	COG2130	NADP-dependent
I6K11_RS02110	COG1247	-acetyltransferase
I6K11_RS02115	COG3238	Protein conserved in bacteria
I6K11_RS02140	COG1177	transmembrane transport
I6K11_RS02145	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K11_RS02150	COG3842	ATPase activity
I6K11_RS02155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K11_RS02160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K11_RS02165	COG1598	PFAM Uncharacterised protein family UPF0150
I6K11_RS02170	COG1724	mRNA binding
I6K11_RS02180	COG0826	peptidase U32
I6K11_RS02185	COG1396	sequence-specific DNA binding
I6K11_RS02190	COG3135	benzoate transporter
I6K11_RS02205	COG0500	methyltransferase
I6K11_RS02210	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K11_RS02215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K11_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K11_RS02225	COG2841	Protein conserved in bacteria
I6K11_RS02235	COG5383	Protein conserved in bacteria
I6K11_RS02240	COG0583	DNA-binding transcription factor activity
I6K11_RS02245	COG0840	transmembrane signaling receptor activity
I6K11_RS02260	COG3038	cytochrome b561
I6K11_RS02265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K11_RS02270	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS02275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K11_RS02295	COG1643	Atp-dependent helicase
I6K11_RS02305	COG0671	phosphoesterase, PA-phosphatase related
I6K11_RS02305	COG2453	phosphatase
I6K11_RS02310	COG2267	carboxylic ester hydrolase activity
I6K11_RS02320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K11_RS02330	COG0667	Aldo Keto reductase
I6K11_RS02340	COG3784	Protein of unknown function (DUF1318)
I6K11_RS02350	COG2911	Protein conserved in bacteria
I6K11_RS02355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K11_RS02360	COG3187	Heat shock protein
I6K11_RS02365	COG3042	response to heat
I6K11_RS02370	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K11_RS02370	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K11_RS02370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K11_RS02370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K11_RS02375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K11_RS02380	COG0589	response to stress
I6K11_RS02390	COG1121	(ABC) transporter
I6K11_RS02395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K11_RS02400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K11_RS02430	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS02465	COG1196	nuclear chromosome segregation
I6K11_RS02515	COG1030	water channel activity
I6K11_RS02535	COG4220	transposase activity
I6K11_RS02545	COG5562	phage envelope protein
I6K11_RS02570	COG1278	Cold shock
I6K11_RS02580	COG3772	lysozyme
I6K11_RS02600	COG1278	Cold shock
I6K11_RS02605	COG1278	Cold shock
I6K11_RS02615	COG0484	heat shock protein binding
I6K11_RS02620	COG1403	HNH endonuclease
I6K11_RS02640	COG2026	Addiction module toxin, RelE StbE family
I6K11_RS02645	COG3077	Addiction module antitoxin, RelB DinJ family
I6K11_RS02660	COG2801	Transposase and inactivated derivatives
I6K11_RS02675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K11_RS02685	COG1846	Transcriptional regulator
I6K11_RS02700	COG1396	sequence-specific DNA binding
I6K11_RS02725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS02740	COG3436	PFAM IS66 Orf2 family protein
I6K11_RS02745	COG4372	Transposase
I6K11_RS02750	COG0582	viral genome integration into host DNA
I6K11_RS02760	COG1063	alcohol dehydrogenase
I6K11_RS02765	COG4948	Mandelate Racemase Muconate Lactonizing
I6K11_RS02780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K11_RS02795	COG0243	molybdopterin cofactor binding
I6K11_RS02800	COG0243	molybdopterin cofactor binding
I6K11_RS02805	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS02810	COG3302	dmso reductase anchor subunit
I6K11_RS02815	COG3381	protein complex oligomerization
I6K11_RS02825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K11_RS02830	COG1940	carbohydrate kinase activity
I6K11_RS02835	COG0583	DNA-binding transcription factor activity
I6K11_RS02840	COG2814	Major facilitator Superfamily
I6K11_RS02855	COG3591	Belongs to the peptidase S1B family
I6K11_RS02880	COG4626	Terminase
I6K11_RS02880	COG1802	Transcriptional regulator
I6K11_RS02995	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K11_RS03000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K11_RS03010	COG0531	amino acid
I6K11_RS03020	COG3136	membrane protein required for alginate biosynthesis
I6K11_RS03025	COG0745	RESPONSE REGULATOR receiver
I6K11_RS03030	COG2205	protein histidine kinase activity
I6K11_RS03040	COG0114	fumarate hydratase activity
I6K11_RS03045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS03045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS03050	COG1482	cell wall glycoprotein biosynthetic process
I6K11_RS03055	COG5339	Protein conserved in bacteria
I6K11_RS03070	COG3250	beta-galactosidase activity
I6K11_RS03075	COG1309	transcriptional regulator
I6K11_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS03085	COG1609	Transcriptional regulator
I6K11_RS03090	COG1263	PTS System
I6K11_RS03090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS03095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K11_RS03105	COG0673	inositol 2-dehydrogenase activity
I6K11_RS03145	COG4659	FMN binding
I6K11_RS03155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K11_RS03160	COG3104	oligopeptide transport
I6K11_RS03165	COG0625	glutathione transferase activity
I6K11_RS03170	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K11_RS03185	COG3895	Periplasmic Protein
I6K11_RS03195	COG3133	Outer membrane lipoprotein
I6K11_RS03210	COG1566	PFAM secretion protein HlyD family protein
I6K11_RS03215	COG1289	transmembrane transporter activity
I6K11_RS03220	COG2032	superoxide dismutase activity
I6K11_RS03225	COG4989	oxidoreductase activity
I6K11_RS03230	COG3313	Fe-S protein
I6K11_RS03235	COG1309	transcriptional regulator
I6K11_RS03240	COG1902	pentaerythritol trinitrate reductase activity
I6K11_RS03245	COG0346	lactoylglutathione lyase activity
I6K11_RS03255	COG1201	RNA secondary structure unwinding
I6K11_RS03260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K11_RS03265	COG0791	NLP P60 protein
I6K11_RS03270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K11_RS03275	COG2814	Major facilitator Superfamily
I6K11_RS03290	COG0583	DNA-binding transcription factor activity
I6K11_RS03295	COG2814	Major facilitator Superfamily
I6K11_RS03300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K11_RS03305	COG0307	riboflavin synthase, alpha
I6K11_RS03315	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS03335	COG4529	Protein conserved in bacteria
I6K11_RS03345	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6K11_RS03350	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS03360	COG2414	aldehyde ferredoxin oxidoreductase
I6K11_RS03365	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS03375	COG0469	pyruvate kinase activity
I6K11_RS03380	COG4238	major outer membrane lipoprotein
I6K11_RS03385	COG1376	ErfK ybiS ycfS ynhG family protein
I6K11_RS03400	COG0719	Fe-S assembly protein
I6K11_RS03405	COG0396	ATPase activity
I6K11_RS03410	COG0719	Fe-S assembly protein
I6K11_RS03415	COG0316	Belongs to the HesB IscA family
I6K11_RS03425	COG2050	protein possibly involved in aromatic compounds catabolism
I6K11_RS03430	COG0277	FAD linked oxidase domain protein
I6K11_RS03430	COG0247	lactate metabolic process
I6K11_RS03435	COG0628	permease
I6K11_RS03450	COG0738	Major facilitator superfamily
I6K11_RS03455	COG2271	Major facilitator Superfamily
I6K11_RS03470	COG4670	ketone body catabolic process
I6K11_RS03475	COG1960	acyl-CoA dehydrogenase activity
I6K11_RS03480	COG2207	Transcriptional regulator
I6K11_RS03480	COG1917	Cupin 2, conserved barrel domain protein
I6K11_RS03485	COG2086	electron transfer activity
I6K11_RS03490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K11_RS03495	COG0644	oxidoreductase
I6K11_RS03500	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K11_RS03505	COG0318	PFAM AMP-dependent synthetase and ligase
I6K11_RS03510	COG0574	Belongs to the PEP-utilizing enzyme family
I6K11_RS03510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K11_RS03520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K11_RS03525	COG4256	Hemin uptake protein
I6K11_RS03535	COG2200	EAL domain
I6K11_RS03540	COG0791	NLP P60 protein
I6K11_RS03550	COG0386	Belongs to the glutathione peroxidase family
I6K11_RS03610	COG3137	Salt-induced outer membrane protein
I6K11_RS03615	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K11_RS03625	COG3001	Fructosamine kinase
I6K11_RS03635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K11_RS03640	COG1988	membrane-bound metal-dependent
I6K11_RS03645	COG1823	symporter activity
I6K11_RS03660	COG0753	catalase activity
I6K11_RS03665	COG3394	polysaccharide catabolic process
I6K11_RS03670	COG1486	melibiose metabolic process
I6K11_RS03675	COG1917	Cupin 2, conserved barrel domain protein
I6K11_RS03675	COG2169	Transcriptional regulator
I6K11_RS03680	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K11_RS03685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K11_RS03690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K11_RS03695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K11_RS03705	COG0322	excinuclease ABC activity
I6K11_RS03715	COG3678	ATP-independent chaperone mediated protein folding
I6K11_RS03745	COG0708	Exodeoxyribonuclease III
I6K11_RS03750	COG0398	Pfam SNARE associated Golgi protein
I6K11_RS03760	COG0398	Pfam SNARE associated Golgi protein
I6K11_RS03765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K11_RS03770	COG4134	Bacterial extracellular solute-binding protein
I6K11_RS03775	COG4135	transport system, permease component
I6K11_RS03780	COG4136	ATPase activity
I6K11_RS03785	COG2897	thiosulfate sulfurtransferase activity
I6K11_RS03790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K11_RS03795	COG0494	nUDIX hydrolase
I6K11_RS03805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K11_RS03810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K11_RS03820	COG0778	Nitroreductase
I6K11_RS03825	COG0616	signal peptide processing
I6K11_RS03830	COG0252	asparaginase activity
I6K11_RS03835	COG1335	isochorismatase
I6K11_RS03840	COG2814	Major facilitator Superfamily
I6K11_RS03845	COG1349	DNA-binding transcription factor activity
I6K11_RS03850	COG0667	Aldo Keto reductase
I6K11_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS03860	COG0191	fructose-bisphosphate aldolase activity
I6K11_RS03865	COG1063	alcohol dehydrogenase
I6K11_RS03870	COG2271	Major facilitator Superfamily
I6K11_RS03875	COG1063	alcohol dehydrogenase
I6K11_RS03880	COG3139	Protein of unknown function (DUF1315)
I6K11_RS03890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K11_RS03895	COG0676	glucose-6-phosphate 1-epimerase activity
I6K11_RS03900	COG0656	L-ascorbic acid biosynthetic process
I6K11_RS03905	COG3713	MltA-interacting MipA family protein
I6K11_RS03910	COG2766	serine protein kinase
I6K11_RS03920	COG2199	diguanylate cyclase activity
I6K11_RS03925	COG2199	diguanylate cyclase activity
I6K11_RS03930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K11_RS03945	COG2207	Transcriptional regulator
I6K11_RS03950	COG2807	transmembrane transport
I6K11_RS03955	COG3189	MarR family transcriptional regulator
I6K11_RS03960	COG3042	response to heat
I6K11_RS03965	COG2199	diguanylate cyclase activity
I6K11_RS03965	COG2203	Gaf domain
I6K11_RS03980	COG2261	transglycosylase associated protein
I6K11_RS03990	COG3615	Tellurite resistance protein tehB
I6K11_RS04000	COG0583	DNA-binding transcription factor activity
I6K11_RS04005	COG0473	3-isopropylmalate dehydrogenase activity
I6K11_RS04010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K11_RS04015	COG4638	Rieske (2fe-2S)
I6K11_RS04025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K11_RS04030	COG0318	PFAM AMP-dependent synthetase and ligase
I6K11_RS04035	COG3065	identical protein binding
I6K11_RS04040	COG1214	PFAM Peptidase M22, glycoprotease
I6K11_RS04045	COG1199	ATP-dependent helicase activity
I6K11_RS04050	COG0251	oxidation-reduction process
I6K11_RS04065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K11_RS04075	COG1760	l-serine dehydratase
I6K11_RS04080	COG2200	EAL domain
I6K11_RS04085	COG1253	flavin adenine dinucleotide binding
I6K11_RS04090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS04090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS04095	COG3715	PTS system
I6K11_RS04100	COG3716	PTS system mannose fructose sorbose family IID component
I6K11_RS04115	COG2226	methyltransferase
I6K11_RS04145	COG1414	Transcriptional regulator
I6K11_RS04150	COG2814	Major facilitator Superfamily
I6K11_RS04160	COG0793	Belongs to the peptidase S41A family
I6K11_RS04170	COG1956	GAF domain-containing protein
I6K11_RS04175	COG2995	paraquat-inducible protein a
I6K11_RS04180	COG3008	intermembrane lipid transfer
I6K11_RS04200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K11_RS04210	COG1276	copper resistance
I6K11_RS04215	COG2372	response to copper ion
I6K11_RS04225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K11_RS04230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS04235	COG1770	oligopeptidase
I6K11_RS04240	COG2979	Protein of unknown function (DUF533)
I6K11_RS04250	COG3141	response to X-ray
I6K11_RS04260	COG0800	Aldolase
I6K11_RS04265	COG0129	dihydroxy-acid dehydratase activity
I6K11_RS04270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K11_RS04275	COG1737	Transcriptional regulator
I6K11_RS04280	COG0469	pyruvate kinase activity
I6K11_RS04285	COG1560	Kdo2-lipid A biosynthetic process
I6K11_RS04290	COG0739	heme binding
I6K11_RS04295	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K11_RS04305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K11_RS04335	COG0217	transcriptional regulatory protein
I6K11_RS04340	COG0494	nUDIX hydrolase
I6K11_RS04350	COG1335	isochorismatase
I6K11_RS04355	COG1801	Protein of unknown function DUF72
I6K11_RS04360	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K11_RS04375	COG0243	molybdopterin cofactor binding
I6K11_RS04380	COG3005	denitrification pathway
I6K11_RS04390	COG3102	Protein conserved in bacteria
I6K11_RS04405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K11_RS04410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K11_RS04415	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K11_RS04420	COG0745	RESPONSE REGULATOR receiver
I6K11_RS04430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6K11_RS04435	COG0840	transmembrane signaling receptor activity
I6K11_RS04440	COG0840	transmembrane signaling receptor activity
I6K11_RS04445	COG0835	chemotaxis
I6K11_RS04450	COG0643	Histidine kinase
I6K11_RS04450	COG2198	Histidine kinase
I6K11_RS04455	COG1360	Flagellar Motor Protein
I6K11_RS04460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K11_RS04475	COG0589	response to stress
I6K11_RS04485	COG1877	trehalose-phosphatase activity
I6K11_RS04490	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS04495	COG1129	ABC transporter
I6K11_RS04500	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS04505	COG1528	Iron-storage protein
I6K11_RS04525	COG1528	Iron-storage protein
I6K11_RS04535	COG0814	amino acid
I6K11_RS04540	COG3012	SEC-C Motif Domain Protein
I6K11_RS04540	COG3318	Belongs to the UPF0149 family
I6K11_RS04570	COG2197	response regulator
I6K11_RS04585	COG2197	response regulator
I6K11_RS04590	COG1126	abc transporter atp-binding protein
I6K11_RS04595	COG0765	amino acid transport
I6K11_RS04605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS04615	COG1191	sigma factor activity
I6K11_RS04625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K11_RS04630	COG1516	flagellar protein fliS
I6K11_RS04640	COG0366	Alpha amylase catalytic
I6K11_RS04650	COG2391	methyltransferase activity
I6K11_RS04655	COG0425	Belongs to the sulfur carrier protein TusA family
I6K11_RS04660	COG2135	peptidase activity
I6K11_RS04675	COG2207	Transcriptional regulator
I6K11_RS04680	COG1881	PFAM PEBP family protein
I6K11_RS04685	COG2076	Multidrug Resistance protein
I6K11_RS04695	COG1766	The M ring may be actively involved in energy transduction
I6K11_RS04700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K11_RS04705	COG1317	bacterial-type flagellum organization
I6K11_RS04710	COG1157	protein secretion by the type III secretion system
I6K11_RS04715	COG2882	bacterial-type flagellum organization
I6K11_RS04720	COG3144	bacterial-type flagellum assembly
I6K11_RS04725	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K11_RS04730	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K11_RS04735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K11_RS04740	COG3190	flagellar
I6K11_RS04745	COG1338	Plays a role in the flagellum-specific transport system
I6K11_RS04750	COG1987	bacterial-type flagellum assembly
I6K11_RS04755	COG1684	flagellar biosynthetic protein fliR
I6K11_RS04760	COG2197	response regulator
I6K11_RS04785	COG5475	Uncharacterized small protein (DUF2158)
I6K11_RS04790	COG2354	Protein conserved in bacteria
I6K11_RS04795	COG0697	spore germination
I6K11_RS04800	COG3727	T/G mismatch-specific endonuclease activity
I6K11_RS04805	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K11_RS04825	COG2205	protein histidine kinase activity
I6K11_RS04830	COG0745	RESPONSE REGULATOR receiver
I6K11_RS04835	COG2351	hydroxyisourate hydrolase activity
I6K11_RS04850	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K11_RS04875	COG1169	isochorismate synthase
I6K11_RS04880	COG2814	Major facilitator Superfamily
I6K11_RS04885	COG1132	(ABC) transporter
I6K11_RS04900	COG2226	methyltransferase
I6K11_RS04900	COG3433	isochorismatase activity
I6K11_RS04900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K11_RS04920	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K11_RS04925	COG4771	TonB-dependent receptor
I6K11_RS04930	COG2373	Large extracellular alpha-helical protein
I6K11_RS04930	COG1388	LysM domain
I6K11_RS04930	COG4932	domain protein
I6K11_RS04945	COG0477	Major facilitator Superfamily
I6K11_RS04950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K11_RS04955	COG0217	transcriptional regulatory protein
I6K11_RS04965	COG0534	Mate efflux family protein
I6K11_RS04975	COG0583	DNA-binding transcription factor activity
I6K11_RS04980	COG0583	DNA-binding transcription factor activity
I6K11_RS04990	COG1376	ErfK ybiS ycfS ynhG family protein
I6K11_RS05005	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6K11_RS05040	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K11_RS05145	COG2003	Belongs to the UPF0758 family
I6K11_RS05190	COG1289	transmembrane transporter activity
I6K11_RS05200	COG1686	Belongs to the peptidase S11 family
I6K11_RS05205	COG2925	Exonuclease
I6K11_RS05210	COG0425	Belongs to the sulfur carrier protein TusA family
I6K11_RS05215	COG2391	methyltransferase activity
I6K11_RS05220	COG0531	amino acid
I6K11_RS05230	COG0583	DNA-binding transcription factor activity
I6K11_RS05235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K11_RS05240	COG4115	mRNA cleavage
I6K11_RS05245	COG2161	toxin-antitoxin pair type II binding
I6K11_RS05270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K11_RS05270	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K11_RS05275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K11_RS05300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6K11_RS05310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K11_RS05330	COG1216	Glycosyl transferase, family 2
I6K11_RS05340	COG4641	Protein conserved in bacteria
I6K11_RS05340	COG0438	transferase activity, transferring glycosyl groups
I6K11_RS05355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K11_RS05365	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K11_RS05370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K11_RS05375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K11_RS05385	COG0438	transferase activity, transferring glycosyl groups
I6K11_RS05390	COG2327	Polysaccharide pyruvyl transferase
I6K11_RS05395	COG2244	polysaccharide biosynthetic process
I6K11_RS05400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K11_RS05405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K11_RS05410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6K11_RS05410	COG0662	Cupin 2, conserved barrel domain protein
I6K11_RS05415	COG0297	glycogen (starch) synthase activity
I6K11_RS05420	COG1051	belongs to the nudix hydrolase family
I6K11_RS05425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K11_RS05430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6K11_RS05435	COG0110	maltose O-acetyltransferase activity
I6K11_RS05440	COG1216	Glycosyl transferase, family 2
I6K11_RS05450	COG0438	transferase activity, transferring glycosyl groups
I6K11_RS05455	COG1045	serine acetyltransferase
I6K11_RS05460	COG0463	Glycosyl transferase, family 2
I6K11_RS05465	COG3206	protein involved in exopolysaccharide biosynthesis
I6K11_RS05465	COG0489	protein tyrosine kinase activity
I6K11_RS05470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K11_RS05475	COG1596	polysaccharide export
I6K11_RS05480	COG1253	flavin adenine dinucleotide binding
I6K11_RS05485	COG2982	Protein involved in outer membrane biogenesis
I6K11_RS05495	COG0572	uridine kinase
I6K11_RS05500	COG3447	MASE1 domain protein
I6K11_RS05500	COG5002	protein histidine kinase activity
I6K11_RS05500	COG5001	Diguanylate cyclase
I6K11_RS05505	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K11_RS05510	COG0443	Heat shock 70 kDa protein
I6K11_RS05515	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6K11_RS05520	COG3779	Protein conserved in bacteria
I6K11_RS05525	COG0631	protein serine/threonine phosphatase activity
I6K11_RS05530	COG4245	von Willebrand factor, type A
I6K11_RS05570	COG2205	protein histidine kinase activity
I6K11_RS05575	COG0745	RESPONSE REGULATOR receiver
I6K11_RS05585	COG0826	peptidase U32
I6K11_RS05640	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS05735	COG4695	Portal protein
I6K11_RS05800	COG4974	Belongs to the 'phage' integrase family
I6K11_RS05820	COG1063	alcohol dehydrogenase
I6K11_RS05825	COG3775	system Galactitol-specific IIC component
I6K11_RS05830	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K11_RS05835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS05850	COG1830	Aldolase
I6K11_RS05855	COG2211	Major facilitator Superfamily
I6K11_RS05860	COG1397	ADP-ribosylglycohydrolase
I6K11_RS05865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS05870	COG2188	Transcriptional regulator
I6K11_RS05875	COG3757	hydrolase, family 25
I6K11_RS05880	COG0351	phosphomethylpyrimidine kinase
I6K11_RS05900	COG5455	response to cobalt ion
I6K11_RS05905	COG3539	Fimbrial protein
I6K11_RS05910	COG3188	usher protein
I6K11_RS05915	COG3121	Chaperone
I6K11_RS05920	COG3539	Fimbrial protein
I6K11_RS05930	COG0489	protein tyrosine kinase activity
I6K11_RS05940	COG3831	ATPase activity
I6K11_RS05945	COG3831	ATPase activity
I6K11_RS05955	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K11_RS05960	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K11_RS05965	COG4715	Zinc finger, swim domain protein
I6K11_RS05970	COG4808	Protein conserved in bacteria
I6K11_RS05975	COG4807	Protein conserved in bacteria
I6K11_RS05980	COG3279	Response regulator of the LytR AlgR family
I6K11_RS05985	COG3275	phosphorelay sensor kinase activity
I6K11_RS05990	COG0789	Transcriptional regulator
I6K11_RS06000	COG1174	glycine betaine transport
I6K11_RS06005	COG1125	glycine betaine transport
I6K11_RS06010	COG1174	glycine betaine transport
I6K11_RS06015	COG1732	Glycine betaine
I6K11_RS06020	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K11_RS06025	COG0277	FAD linked oxidase domain protein
I6K11_RS06030	COG1686	Belongs to the peptidase S11 family
I6K11_RS06040	COG0586	Pfam SNARE associated Golgi protein
I6K11_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS06050	COG1538	Outer membrane efflux protein
I6K11_RS06060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K11_RS06070	COG1346	cytolysis
I6K11_RS06080	COG2949	membrane
I6K11_RS06090	COG0493	'glutamate synthase
I6K11_RS06095	COG0167	dihydroorotate dehydrogenase activity
I6K11_RS06095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K11_RS06100	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS06105	COG1129	ABC transporter
I6K11_RS06110	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS06115	COG1609	Transcriptional regulator
I6K11_RS06120	COG2311	Membrane
I6K11_RS06135	COG4771	TonB-dependent receptor
I6K11_RS06140	COG0833	amino acid
I6K11_RS06145	COG0583	DNA-binding transcription factor activity
I6K11_RS06150	COG2855	membrane
I6K11_RS06160	COG1522	sequence-specific DNA binding
I6K11_RS06160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS06165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K11_RS06175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K11_RS06180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K11_RS06185	COG2313	pseudouridylate synthase activity
I6K11_RS06190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS06195	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K11_RS06195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS06195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS06200	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K11_RS06205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS06205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS06210	COG2814	Major facilitator Superfamily
I6K11_RS06225	COG0246	Mannitol dehydrogenase
I6K11_RS06230	COG0523	cobalamin synthesis protein
I6K11_RS06235	COG0671	phosphoesterase, PA-phosphatase related
I6K11_RS06240	COG0791	NLP P60 protein
I6K11_RS06245	COG2200	EAL domain
I6K11_RS06250	COG4166	transmembrane transport
I6K11_RS06255	COG4174	ABC transporter (Permease)
I6K11_RS06260	COG4239	(ABC) transporter, permease
I6K11_RS06265	COG4172	Belongs to the ABC transporter superfamily
I6K11_RS06275	COG2814	Major facilitator Superfamily
I6K11_RS06280	COG1187	pseudouridine synthase activity
I6K11_RS06285	COG1061	Type III restriction enzyme res subunit
I6K11_RS06305	COG3083	sulfuric ester hydrolase activity
I6K11_RS06315	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS06320	COG2197	response regulator
I6K11_RS06325	COG4235	cytochrome complex assembly
I6K11_RS06325	COG3088	subunit of a heme lyase
I6K11_RS06330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K11_RS06335	COG1138	Cytochrome C-type biogenesis protein
I6K11_RS06345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K11_RS06350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K11_RS06355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K11_RS06360	COG4133	protoheme IX ABC transporter activity
I6K11_RS06365	COG3005	denitrification pathway
I6K11_RS06370	COG3043	anaerobic respiration
I6K11_RS06375	COG0348	domain, Protein
I6K11_RS06380	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS06390	COG3062	negative regulation of establishment of protein localization
I6K11_RS06395	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS06395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS06410	COG4615	Cyclic peptide transporter
I6K11_RS06415	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K11_RS06420	COG2169	Transcriptional regulator
I6K11_RS06420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K11_RS06425	COG1477	protein flavinylation
I6K11_RS06430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K11_RS06435	COG0642	Histidine kinase
I6K11_RS06435	COG2198	Histidine kinase
I6K11_RS06440	COG2197	response regulator
I6K11_RS06445	COG0784	Response regulator, receiver
I6K11_RS06445	COG2205	protein histidine kinase activity
I6K11_RS06450	COG3852	Histidine kinase
I6K11_RS06455	COG2204	response regulator
I6K11_RS06460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K11_RS06465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K11_RS06470	COG2031	fatty acid transporter
I6K11_RS06475	COG0183	Belongs to the thiolase family
I6K11_RS06480	COG4676	Protein conserved in bacteria
I6K11_RS06485	COG5445	Predicted secreted protein (DUF2300)
I6K11_RS06490	COG2373	Large extracellular alpha-helical protein
I6K11_RS06495	COG3234	Protein of unknown function (DUF1175)
I6K11_RS06500	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6K11_RS06505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K11_RS06515	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS06520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K11_RS06525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K11_RS06530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K11_RS06535	COG3642	lipopolysaccharide core region biosynthetic process
I6K11_RS06540	COG2814	Major facilitator Superfamily
I6K11_RS06545	COG0583	DNA-binding transcription factor activity
I6K11_RS06550	COG0584	glycerophosphoryl diester phosphodiesterase
I6K11_RS06555	COG2271	Major facilitator Superfamily
I6K11_RS06560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K11_RS06570	COG0247	lactate metabolic process
I6K11_RS06575	COG5464	transposase or invertase
I6K11_RS06590	COG2271	Major facilitator Superfamily
I6K11_RS06600	COG1414	Transcriptional regulator
I6K11_RS06665	COG0318	PFAM AMP-dependent synthetase and ligase
I6K11_RS06675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K11_RS06690	COG1169	isochorismate synthase
I6K11_RS06695	COG4575	ribosome binding
I6K11_RS06700	COG2153	protein acetylation
I6K11_RS06710	COG5160	protein modification by small protein removal
I6K11_RS06715	COG2234	aminopeptidase activity
I6K11_RS06730	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K11_RS06735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K11_RS06745	COG0839	Belongs to the complex I subunit 6 family
I6K11_RS06760	COG1034	ATP synthesis coupled electron transport
I6K11_RS06765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K11_RS06770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K11_RS06790	COG0583	DNA-binding transcription factor activity
I6K11_RS06795	COG0436	Aminotransferase
I6K11_RS06805	COG0471	metal ion transport
I6K11_RS06805	COG0490	domain, Protein
I6K11_RS06810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K11_RS06825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K11_RS06830	COG0857	belongs to the CobB CobQ family
I6K11_RS06830	COG0280	phosphate acetyltransferase
I6K11_RS06835	COG1288	antiporter activity
I6K11_RS06840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K11_RS06845	COG0622	Phosphoesterase
I6K11_RS06850	COG0625	glutathione transferase activity
I6K11_RS06855	COG0625	glutathione transferase activity
I6K11_RS06860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K11_RS06865	COG1090	epimerase
I6K11_RS06870	COG5464	transposase or invertase
I6K11_RS06875	COG4598	ABC transporter
I6K11_RS06880	COG4160	amino acid transport
I6K11_RS06885	COG4215	(ABC) transporter
I6K11_RS06890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS06895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS06900	COG0163	prenyltransferase activity
I6K11_RS06905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K11_RS06910	COG1286	toxin biosynthetic process
I6K11_RS06915	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K11_RS06920	COG0285	dihydrofolate synthase activity
I6K11_RS06930	COG0586	Pfam SNARE associated Golgi protein
I6K11_RS06940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K11_RS06955	COG2814	Major facilitator Superfamily
I6K11_RS06960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K11_RS06975	COG3101	peptidyl-lysine hydroxylation
I6K11_RS06980	COG0730	response to heat
I6K11_RS06995	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K11_RS07010	COG3539	Fimbrial protein
I6K11_RS07015	COG3539	Fimbrial protein
I6K11_RS07020	COG3539	Fimbrial protein
I6K11_RS07025	COG3121	Chaperone
I6K11_RS07030	COG3188	usher protein
I6K11_RS07035	COG3539	Fimbrial protein
I6K11_RS07040	COG2062	phosphohistidine phosphatase, SixA
I6K11_RS07055	COG3691	Protein conserved in bacteria
I6K11_RS07060	COG2067	long-chain fatty acid transport protein
I6K11_RS07070	COG2853	Lipoprotein
I6K11_RS07075	COG2116	formate transmembrane transporter activity
I6K11_RS07085	COG0582	viral genome integration into host DNA
I6K11_RS07185	COG0477	Major facilitator Superfamily
I6K11_RS07190	COG1566	PFAM secretion protein HlyD family protein
I6K11_RS07195	COG2197	response regulator
I6K11_RS07200	COG2205	protein histidine kinase activity
I6K11_RS07200	COG2198	Histidine kinase
I6K11_RS07200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS07200	COG0784	Response regulator, receiver
I6K11_RS07205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K11_RS07210	COG0679	Auxin Efflux Carrier
I6K11_RS07215	COG0028	Belongs to the TPP enzyme family
I6K11_RS07240	COG1560	Kdo2-lipid A biosynthetic process
I6K11_RS07250	COG0436	Aminotransferase
I6K11_RS07255	COG3275	phosphorelay sensor kinase activity
I6K11_RS07260	COG3279	Response regulator of the LytR AlgR family
I6K11_RS07265	COG2207	Transcriptional regulator
I6K11_RS07270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K11_RS07270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS07270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS07275	COG1363	Peptidase, m42
I6K11_RS07280	COG0006	proline dipeptidase activity
I6K11_RS07285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS07290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS07315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K11_RS07320	COG2200	EAL domain
I6K11_RS07320	COG2199	diguanylate cyclase activity
I6K11_RS07335	COG3415	Transposase
I6K11_RS07340	COG3415	Transposase
I6K11_RS07375	COG0583	DNA-binding transcription factor activity
I6K11_RS07385	COG2211	Major facilitator Superfamily
I6K11_RS07390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K11_RS07400	COG0583	DNA-binding transcription factor activity
I6K11_RS07405	COG0385	Bile acid
I6K11_RS07410	COG3530	Putative quorum-sensing-regulated virulence factor
I6K11_RS07430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K11_RS07435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS07440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K11_RS07445	COG2190	(PTS) system
I6K11_RS07460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K11_RS07465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K11_RS07470	COG4208	sulfate ABC transporter
I6K11_RS07475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K11_RS07480	COG4150	thiosulfate binding
I6K11_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS07500	COG1263	PTS System
I6K11_RS07500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS07505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K11_RS07515	COG2837	iron assimilation
I6K11_RS07535	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K11_RS07545	COG2207	Transcriptional regulator
I6K11_RS07550	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K11_RS07555	COG4816	utilization protein
I6K11_RS07565	COG4303	Ethanolamine ammonia lyase large subunit
I6K11_RS07570	COG4819	ethanolamine utilization protein
I6K11_RS07575	COG3192	ethanolamine utilization protein
I6K11_RS07580	COG1454	alcohol dehydrogenase
I6K11_RS07585	COG4820	ethanolamine utilization protein (EutJ)
I6K11_RS07590	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS07595	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K11_RS07600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K11_RS07605	COG0280	phosphate acetyltransferase
I6K11_RS07610	COG4812	Cobalamin adenosyltransferase
I6K11_RS07615	COG4766	ethanolamine catabolic process
I6K11_RS07620	COG4917	ethanolamine utilization protein
I6K11_RS07625	COG4810	utilization protein
I6K11_RS07630	COG0280	phosphate acetyltransferase
I6K11_RS07630	COG0281	malic enzyme
I6K11_RS07635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K11_RS07640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K11_RS07645	COG5342	invasion associated locus B
I6K11_RS07655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS07655	COG0493	'glutamate synthase
I6K11_RS07660	COG3850	Histidine kinase
I6K11_RS07665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K11_RS07680	COG1393	Belongs to the ArsC family
I6K11_RS07695	COG0400	carboxylic ester hydrolase activity
I6K11_RS07705	COG2321	neutral zinc metallopeptidase
I6K11_RS07715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K11_RS07725	COG2716	regulation of RNA biosynthetic process
I6K11_RS07730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K11_RS07735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS07740	COG0651	ATP synthesis coupled electron transport
I6K11_RS07745	COG0650	Formate hydrogenlyase subunit 4
I6K11_RS07750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K11_RS07755	COG4237	Hydrogenase 4 membrane
I6K11_RS07760	COG0651	ATP synthesis coupled electron transport
I6K11_RS07765	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K11_RS07765	COG3261	NADH dehydrogenase
I6K11_RS07770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K11_RS07775	COG3260	NADH ubiquinone oxidoreductase 20
I6K11_RS07785	COG3604	Transcriptional regulator
I6K11_RS07790	COG2116	formate transmembrane transporter activity
I6K11_RS07795	COG0628	permease
I6K11_RS07800	COG4783	chaperone-mediated protein folding
I6K11_RS07805	COG1393	Belongs to the ArsC family
I6K11_RS07815	COG2233	PERMEase
I6K11_RS07830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K11_RS07835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6K11_RS07840	COG0248	Ppx GppA phosphatase
I6K11_RS07845	COG2200	EAL domain
I6K11_RS07860	COG3133	Outer membrane lipoprotein
I6K11_RS07875	COG0516	GMP reductase activity
I6K11_RS07875	COG0517	IMP dehydrogenase activity
I6K11_RS07900	COG1645	bacterial-type flagellum-dependent swarming motility
I6K11_RS07915	COG2976	Protein conserved in bacteria
I6K11_RS07945	COG4953	penicillin-binding protein 1C
I6K11_RS07950	COG2373	Large extracellular alpha-helical protein
I6K11_RS07955	COG2897	thiosulfate sulfurtransferase activity
I6K11_RS07970	COG2975	iron-sulfur cluster assembly
I6K11_RS07975	COG0633	Ferredoxin
I6K11_RS07995	COG0822	iron-sulfur transferase activity
I6K11_RS08015	COG0483	inositol monophosphate 1-phosphatase activity
I6K11_RS08020	COG1073	alpha beta
I6K11_RS08025	COG3711	transcriptional antiterminator
I6K11_RS08030	COG2814	Major facilitator Superfamily
I6K11_RS08035	COG0583	DNA-binding transcription factor activity
I6K11_RS08040	COG4638	Rieske (2fe-2S)
I6K11_RS08065	COG2259	Doxx family
I6K11_RS08070	COG2017	converts alpha-aldose to the beta-anomer
I6K11_RS08075	COG1063	alcohol dehydrogenase
I6K11_RS08080	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS08085	COG1129	ABC transporter
I6K11_RS08090	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS08095	COG0457	Tetratricopeptide repeat
I6K11_RS08100	COG1940	carbohydrate kinase activity
I6K11_RS08110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K11_RS08110	COG1017	nitric oxide dioxygenase activity
I6K11_RS08115	COG0347	Belongs to the P(II) protein family
I6K11_RS08120	COG2204	response regulator
I6K11_RS08125	COG3170	Tfp pilus assembly protein FimV
I6K11_RS08130	COG2205	protein histidine kinase activity
I6K11_RS08135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K11_RS08135	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K11_RS08150	COG0560	Phosphoserine phosphatase
I6K11_RS08155	COG1737	Transcriptional regulator
I6K11_RS08160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS08175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K11_RS08195	COG0681	Belongs to the peptidase S26 family
I6K11_RS08205	COG3086	response to oxidative stress
I6K11_RS08210	COG3026	antisigma factor binding
I6K11_RS08215	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K11_RS08220	COG1595	DNA-templated transcription, initiation
I6K11_RS08230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K11_RS08240	COG0513	Belongs to the DEAD box helicase family
I6K11_RS08245	COG0583	DNA-binding transcription factor activity
I6K11_RS08265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K11_RS08270	COG3118	belongs to the thioredoxin family
I6K11_RS08275	COG3148	PFAM DTW domain containing protein
I6K11_RS08280	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K11_RS08280	COG1042	CoA-binding domain protein
I6K11_RS08280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K11_RS08285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K11_RS08290	COG5544	Lipoprotein
I6K11_RS08295	COG0477	Major facilitator Superfamily
I6K11_RS08325	COG0542	response to heat
I6K11_RS08335	COG0564	pseudouridine synthase activity
I6K11_RS08340	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K11_RS08345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K11_RS08355	COG1605	Chorismate mutase
I6K11_RS08355	COG0077	Prephenate dehydratase
I6K11_RS08360	COG0287	Prephenate dehydrogenase
I6K11_RS08360	COG1605	Chorismate mutase
I6K11_RS08365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K11_RS08380	COG2199	diguanylate cyclase activity
I6K11_RS08385	COG2885	chlorophyll binding
I6K11_RS08410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K11_RS08415	COG4137	Cytochrome C assembly protein
I6K11_RS08420	COG4536	flavin adenine dinucleotide binding
I6K11_RS08435	COG0497	DNA recombination
I6K11_RS08440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K11_RS08450	COG2867	negative regulation of translational initiation
I6K11_RS08465	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS08490	COG0366	Alpha amylase catalytic
I6K11_RS08500	COG0579	oxidoreductase
I6K11_RS08505	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS08510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K11_RS08515	COG1113	amino acid transport
I6K11_RS08520	COG1802	Transcriptional regulator
I6K11_RS08525	COG1652	LysM domain
I6K11_RS08530	COG0401	homolog of Blt101
I6K11_RS08535	COG0640	Transcriptional regulator
I6K11_RS08540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K11_RS08545	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K11_RS08560	COG4575	ribosome binding
I6K11_RS08565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K11_RS08575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K11_RS08580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K11_RS08585	COG4175	Glycine betaine
I6K11_RS08590	COG4176	ABC-type proline glycine betaine transport system permease component
I6K11_RS08595	COG2113	Glycine betaine
I6K11_RS08600	COG2814	Major facilitator Superfamily
I6K11_RS08605	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K11_RS08615	COG1846	Transcriptional regulator
I6K11_RS08620	COG1566	PFAM secretion protein HlyD family protein
I6K11_RS08625	COG2814	Major facilitator Superfamily
I6K11_RS08640	COG1238	metal cluster binding
I6K11_RS08645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K11_RS08675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K11_RS08695	COG1546	Belongs to the CinA family
I6K11_RS08700	COG2951	lytic endotransglycosylase activity
I6K11_RS08705	COG3730	PTS system glucitol sorbitol-specific
I6K11_RS08710	COG3732	PTS system glucitol sorbitol-specific
I6K11_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS08725	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS08730	COG1349	DNA-binding transcription factor activity
I6K11_RS08755	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K11_RS08760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS08765	COG1609	Transcriptional regulator
I6K11_RS08770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS08770	COG1263	PTS System
I6K11_RS08775	COG2723	6-phospho-beta-galactosidase activity
I6K11_RS08780	COG5499	transcription regulator containing HTH domain
I6K11_RS08785	COG4680	protein conserved in bacteria
I6K11_RS08790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K11_RS08800	COG3260	NADH ubiquinone oxidoreductase 20
I6K11_RS08805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K11_RS08810	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K11_RS08810	COG3261	NADH dehydrogenase
I6K11_RS08815	COG0650	Formate hydrogenlyase subunit 4
I6K11_RS08820	COG0651	ATP synthesis coupled electron transport
I6K11_RS08825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS08835	COG0375	protein maturation
I6K11_RS08840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K11_RS08845	COG0298	carbon dioxide binding
I6K11_RS08850	COG0409	Hydrogenase expression formation protein
I6K11_RS08855	COG0309	Hydrogenase expression formation protein (HypE)
I6K11_RS08860	COG3604	Transcriptional regulator
I6K11_RS08885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K11_RS08890	COG1349	DNA-binding transcription factor activity
I6K11_RS08895	COG2084	Dehydrogenase
I6K11_RS08900	COG3395	kinase activity
I6K11_RS08905	COG0235	Class ii aldolase
I6K11_RS08910	COG3622	Belongs to the hyi family
I6K11_RS08915	COG2610	gluconate transmembrane transporter activity
I6K11_RS08925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K11_RS08930	COG0163	prenyltransferase activity
I6K11_RS08940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K11_RS08945	COG1388	LysM domain
I6K11_RS08945	COG4942	peptidase
I6K11_RS09000	COG2234	aminopeptidase activity
I6K11_RS09005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS09010	COG1518	maintenance of DNA repeat elements
I6K11_RS09025	COG1857	crispr-associated protein
I6K11_RS09040	COG1203	CRISPR-associated helicase, Cas3
I6K11_RS09065	COG0720	synthase
I6K11_RS09070	COG0644	oxidoreductase
I6K11_RS09075	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K11_RS09080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6K11_RS09090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K11_RS09095	COG2086	electron transfer activity
I6K11_RS09100	COG0477	Major facilitator Superfamily
I6K11_RS09105	COG0277	FAD linked oxidase domain protein
I6K11_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS09115	COG2223	nitrite transmembrane transporter activity
I6K11_RS09120	COG1070	Carbohydrate kinase
I6K11_RS09125	COG0602	queuosine metabolic process
I6K11_RS09135	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K11_RS09150	COG3956	TIGRFAM MazG family protein
I6K11_RS09155	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6K11_RS09160	COG2336	PFAM SpoVT AbrB
I6K11_RS09165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K11_RS09175	COG3437	response regulator, receiver
I6K11_RS09175	COG3850	Histidine kinase
I6K11_RS09175	COG2205	protein histidine kinase activity
I6K11_RS09175	COG4999	Histidine kinase
I6K11_RS09180	COG4948	Mandelate Racemase Muconate Lactonizing
I6K11_RS09185	COG4948	Mandelate Racemase Muconate Lactonizing
I6K11_RS09190	COG2271	Major facilitator Superfamily
I6K11_RS09195	COG0716	FMN binding
I6K11_RS09200	COG0564	pseudouridine synthase activity
I6K11_RS09205	COG3098	single-species biofilm formation
I6K11_RS09220	COG1611	Belongs to the LOG family
I6K11_RS09225	COG0814	amino acid
I6K11_RS09230	COG1760	l-serine dehydratase
I6K11_RS09240	COG1454	alcohol dehydrogenase
I6K11_RS09245	COG0235	Class ii aldolase
I6K11_RS09255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K11_RS09260	COG1609	Transcriptional regulator
I6K11_RS09265	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS09270	COG1129	ABC transporter
I6K11_RS09280	COG1070	Carbohydrate kinase
I6K11_RS09290	COG1349	DNA-binding transcription factor activity
I6K11_RS09300	COG2363	Small membrane protein
I6K11_RS09305	COG0583	DNA-binding transcription factor activity
I6K11_RS09315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K11_RS09320	COG2166	iron-sulfur cluster assembly
I6K11_RS09325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K11_RS09330	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K11_RS09360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K11_RS09365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS09365	COG1263	PTS System
I6K11_RS09370	COG3711	transcriptional antiterminator
I6K11_RS09375	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K11_RS09380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K11_RS09380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K11_RS09385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K11_RS09390	COG1074	ATP-dependent DNA helicase activity
I6K11_RS09400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K11_RS09405	COG4967	type IV pilus modification protein PilV
I6K11_RS09415	COG4795	General secretion pathway protein
I6K11_RS09420	COG2165	general secretion pathway protein
I6K11_RS09435	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6K11_RS09450	COG0861	Integral membrane protein TerC family
I6K11_RS09460	COG0667	Aldo Keto reductase
I6K11_RS09480	COG1609	Transcriptional regulator
I6K11_RS09490	COG0583	DNA-binding transcription factor activity
I6K11_RS09495	COG1794	racemase activity, acting on amino acids and derivatives
I6K11_RS09500	COG2814	Major facilitator Superfamily
I6K11_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS09515	COG0183	Belongs to the thiolase family
I6K11_RS09520	COG0814	amino acid
I6K11_RS09525	COG2771	luxR family
I6K11_RS09530	COG3710	Transcriptional regulator
I6K11_RS09555	COG0457	Tetratricopeptide repeat
I6K11_RS09560	COG0457	Tetratricopeptide repeat
I6K11_RS09560	COG3710	Transcriptional regulator
I6K11_RS09570	COG0741	lytic transglycosylase activity
I6K11_RS09575	COG2197	response regulator
I6K11_RS09675	COG2207	Transcriptional regulator
I6K11_RS09685	COG3387	PFAM Glycoside hydrolase 15-related
I6K11_RS09695	COG4942	peptidase
I6K11_RS09700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K11_RS09705	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K11_RS09710	COG2080	2 iron, 2 sulfur cluster binding
I6K11_RS09715	COG3829	transcription factor binding
I6K11_RS09720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K11_RS09725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K11_RS09730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K11_RS09740	COG0549	Belongs to the carbamate kinase family
I6K11_RS09745	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K11_RS09745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K11_RS09750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K11_RS09755	COG2068	MobA-Related Protein
I6K11_RS09760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS09760	COG0493	'glutamate synthase
I6K11_RS09765	COG0402	S-adenosylhomocysteine deaminase activity
I6K11_RS09770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K11_RS09775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K11_RS09775	COG2080	2 iron, 2 sulfur cluster binding
I6K11_RS09780	COG2233	PERMEase
I6K11_RS09785	COG0402	S-adenosylhomocysteine deaminase activity
I6K11_RS09790	COG2252	PERMEase
I6K11_RS09795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS09800	COG0493	'glutamate synthase
I6K11_RS09800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS09805	COG2233	PERMEase
I6K11_RS09825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K11_RS09835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K11_RS09840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K11_RS09845	COG4974	Belongs to the 'phage' integrase family
I6K11_RS09850	COG0716	FMN binding
I6K11_RS09860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K11_RS09870	COG1272	protein, Hemolysin III
I6K11_RS09880	COG2723	6-phospho-beta-galactosidase activity
I6K11_RS09905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K11_RS09910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K11_RS09915	COG0006	proline dipeptidase activity
I6K11_RS09935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K11_RS09945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K11_RS09965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K11_RS09965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K11_RS09970	COG1703	isobutyryl-CoA mutase activity
I6K11_RS09975	COG1024	Enoyl-CoA hydratase
I6K11_RS09980	COG0427	acetyl-CoA hydrolase
I6K11_RS09985	COG0583	DNA-binding transcription factor activity
I6K11_RS09990	COG2968	Membrane
I6K11_RS09995	COG1279	arginine transmembrane transporter activity
I6K11_RS10000	COG0668	transmembrane transport
I6K11_RS10005	COG0191	fructose-bisphosphate aldolase activity
I6K11_RS10020	COG1072	(Pantothenic acid kinase))
I6K11_RS10030	COG1494	fructose-1,6-bisphosphatase
I6K11_RS10035	COG1063	alcohol dehydrogenase
I6K11_RS10040	COG2213	PTS system mannitol-specific
I6K11_RS10045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS10050	COG0330	HflC and HflK could
I6K11_RS10055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K11_RS10060	COG0501	Belongs to the peptidase M48B family
I6K11_RS10080	COG1166	arginine decarboxylase activity
I6K11_RS10100	COG2814	Major facilitator Superfamily
I6K11_RS10110	COG2356	endonuclease I
I6K11_RS10115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K11_RS10120	COG0189	ligase activity
I6K11_RS10135	COG2805	Type II/IV secretion system protein
I6K11_RS10140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K11_RS10145	COG0762	integral membrane protein
I6K11_RS10155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6K11_RS10160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K11_RS10170	COG0252	asparaginase activity
I6K11_RS10180	COG3171	Protein conserved in bacteria
I6K11_RS10190	COG1194	a g-specific adenine glycosylase
I6K11_RS10205	COG2211	Major facilitator Superfamily
I6K11_RS10210	COG1982	Orn Lys Arg decarboxylase major
I6K11_RS10215	COG1811	Na channel or pump
I6K11_RS10225	COG0582	viral genome integration into host DNA
I6K11_RS10230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K11_RS10230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6K11_RS10235	COG2194	sulfuric ester hydrolase activity
I6K11_RS10350	COG3596	GTP binding
I6K11_RS10355	COG2378	regulation of single-species biofilm formation
I6K11_RS10380	COG2003	Belongs to the UPF0758 family
I6K11_RS10460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K11_RS10475	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K11_RS10505	COG2165	general secretion pathway protein
I6K11_RS10510	COG1459	type II secretion system
I6K11_RS10515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K11_RS10540	COG3064	Membrane
I6K11_RS10545	COG1620	l-lactate permease
I6K11_RS10550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K11_RS10555	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K11_RS10560	COG0247	lactate metabolic process
I6K11_RS10565	COG0277	FAD linked oxidase domain protein
I6K11_RS10570	COG0277	FAD linked oxidase domain protein
I6K11_RS10575	COG2186	Transcriptional regulator
I6K11_RS10580	COG0456	acetyltransferase
I6K11_RS10585	COG0318	PFAM AMP-dependent synthetase and ligase
I6K11_RS10595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K11_RS10600	COG0156	8-amino-7-oxononanoate synthase activity
I6K11_RS10610	COG0795	lipopolysaccharide-transporting ATPase activity
I6K11_RS10615	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K11_RS10625	COG2244	polysaccharide biosynthetic process
I6K11_RS10630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K11_RS10635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K11_RS10640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K11_RS10645	COG0306	phosphate transporter
I6K11_RS10650	COG0754	glutathionylspermidine amidase activity
I6K11_RS10655	COG0625	glutathione transferase activity
I6K11_RS10660	COG0298	carbon dioxide binding
I6K11_RS10670	COG1773	rubredoxin
I6K11_RS10675	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K11_RS10680	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K11_RS10685	COG5557	Pfam Polysulphide reductase, NrfD
I6K11_RS10690	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS10695	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K11_RS10710	COG0667	Aldo Keto reductase
I6K11_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS10725	COG0848	biopolymer transport protein
I6K11_RS10730	COG0811	peptide transport
I6K11_RS10735	COG0626	cystathionine gamma-synthase activity
I6K11_RS10740	COG0586	Pfam SNARE associated Golgi protein
I6K11_RS10745	COG2207	Transcriptional regulator
I6K11_RS10750	COG1979	alcohol dehydrogenase
I6K11_RS10755	COG0656	L-ascorbic acid biosynthetic process
I6K11_RS10765	COG4238	major outer membrane lipoprotein
I6K11_RS10770	COG1032	radical SAM domain protein
I6K11_RS10775	COG2132	Multicopper oxidase
I6K11_RS10780	COG0204	Acyl-transferase
I6K11_RS10785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K11_RS10790	COG4166	transmembrane transport
I6K11_RS10795	COG2944	sequence-specific DNA binding
I6K11_RS10805	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K11_RS10810	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K11_RS10815	COG0745	RESPONSE REGULATOR receiver
I6K11_RS10820	COG0642	Histidine kinase
I6K11_RS10830	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K11_RS10835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K11_RS10840	COG0187	DNA topoisomerase II activity
I6K11_RS10845	COG3150	esterase
I6K11_RS10850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K11_RS10855	COG3151	Protein conserved in bacteria
I6K11_RS10860	COG0494	nUDIX hydrolase
I6K11_RS10865	COG1538	Outer membrane efflux protein
I6K11_RS10875	COG0754	glutathionylspermidine amidase activity
I6K11_RS10880	COG3384	dioxygenase
I6K11_RS10900	COG2960	long-chain fatty acid transporting porin activity
I6K11_RS10905	COG3539	Fimbrial protein
I6K11_RS10910	COG3188	usher protein
I6K11_RS10915	COG3121	Chaperone
I6K11_RS10920	COG3539	Fimbrial protein
I6K11_RS10930	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K11_RS10940	COG2268	Band 7 protein
I6K11_RS10965	COG3025	triphosphatase activity
I6K11_RS10970	COG4991	sh3 domain protein
I6K11_RS10985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K11_RS11000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS11005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS11020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K11_RS11025	COG0358	DNA primase activity
I6K11_RS11030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K11_RS11045	COG2375	cellular response to nickel ion
I6K11_RS11050	COG1695	Transcriptional regulator
I6K11_RS11055	COG0840	transmembrane signaling receptor activity
I6K11_RS11065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K11_RS11070	COG1609	Transcriptional regulator
I6K11_RS11075	COG3250	beta-galactosidase activity
I6K11_RS11080	COG2731	YhcH YjgK YiaL family protein
I6K11_RS11085	COG0531	amino acid
I6K11_RS11095	COG3408	Glycogen debranching enzyme
I6K11_RS11095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K11_RS11100	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K11_RS11100	COG1902	pentaerythritol trinitrate reductase activity
I6K11_RS11110	COG1451	nucleotide metabolic process
I6K11_RS11115	COG2949	membrane
I6K11_RS11120	COG0673	inositol 2-dehydrogenase activity
I6K11_RS11125	COG0861	Integral membrane protein TerC family
I6K11_RS11130	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6K11_RS11140	COG2721	sulfolactate sulfo-lyase activity
I6K11_RS11150	COG2271	Major facilitator Superfamily
I6K11_RS11155	COG2186	Transcriptional regulator
I6K11_RS11160	COG0586	Pfam SNARE associated Golgi protein
I6K11_RS11170	COG1422	Protein of unknown function (DUF1090)
I6K11_RS11175	COG4575	ribosome binding
I6K11_RS11180	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K11_RS11190	COG2259	Doxx family
I6K11_RS11195	COG0435	Glutathione S-transferase
I6K11_RS11205	COG3152	Membrane
I6K11_RS11210	COG3152	Membrane
I6K11_RS11215	COG0583	DNA-binding transcription factor activity
I6K11_RS11220	COG1741	Belongs to the pirin family
I6K11_RS11235	COG0814	amino acid
I6K11_RS11240	COG1760	l-serine dehydratase
I6K11_RS11245	COG0251	oxidation-reduction process
I6K11_RS11250	COG1882	Formate acetyltransferase
I6K11_RS11255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K11_RS11265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K11_RS11270	COG0583	DNA-binding transcription factor activity
I6K11_RS11295	COG1929	Belongs to the glycerate kinase type-1 family
I6K11_RS11300	COG2084	Dehydrogenase
I6K11_RS11310	COG2271	Major facilitator Superfamily
I6K11_RS11315	COG2721	sulfolactate sulfo-lyase activity
I6K11_RS11320	COG2002	toxin-antitoxin pair type II binding
I6K11_RS11330	COG1349	DNA-binding transcription factor activity
I6K11_RS11340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS11350	COG3716	PTS system mannose fructose sorbose family IID component
I6K11_RS11355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS11365	COG2222	sugar isomerase
I6K11_RS11375	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS11380	COG3715	PTS system
I6K11_RS11385	COG3716	PTS system mannose fructose sorbose family IID component
I6K11_RS11390	COG0363	glucosamine-6-phosphate deaminase activity
I6K11_RS11395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K11_RS11415	COG2823	Periplasmic or secreted lipoprotein
I6K11_RS11420	COG0701	Predicted permease
I6K11_RS11425	COG0702	epimerase
I6K11_RS11430	COG0693	protein deglycase activity
I6K11_RS11445	COG3153	acetyltransferase
I6K11_RS11450	COG3154	lipid carrier protein
I6K11_RS11455	COG0826	peptidase U32
I6K11_RS11460	COG0826	peptidase U32
I6K11_RS11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K11_RS11470	COG0814	amino acid
I6K11_RS11475	COG0513	Belongs to the DEAD box helicase family
I6K11_RS11515	COG0195	Participates in both transcription termination and antitermination
I6K11_RS11535	COG2194	sulfuric ester hydrolase activity
I6K11_RS11545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K11_RS11555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K11_RS11560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K11_RS11570	COG1534	Rna-binding protein
I6K11_RS11575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K11_RS11580	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K11_RS11590	COG0697	spore germination
I6K11_RS11605	COG0142	geranyltranstransferase activity
I6K11_RS11610	COG3423	Transcriptional regulator
I6K11_RS11620	COG5007	Belongs to the BolA IbaG family
I6K11_RS11625	COG3113	response to antibiotic
I6K11_RS11630	COG2854	intermembrane phospholipid transfer
I6K11_RS11635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K11_RS11640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K11_RS11645	COG1127	ABC transporter
I6K11_RS11650	COG0530	calcium, potassium:sodium antiporter activity
I6K11_RS11655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K11_RS11655	COG0517	IMP dehydrogenase activity
I6K11_RS11660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K11_RS11665	COG3117	lipopolysaccharide transmembrane transporter activity
I6K11_RS11670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K11_RS11675	COG1137	ATPase activity
I6K11_RS11680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K11_RS11685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K11_RS11700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS11705	COG0515	serine threonine protein kinase
I6K11_RS11715	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K11_RS11720	COG2198	Histidine kinase
I6K11_RS11720	COG0784	Response regulator, receiver
I6K11_RS11720	COG5002	protein histidine kinase activity
I6K11_RS11725	COG1242	4 iron, 4 sulfur cluster binding
I6K11_RS11730	COG0067	glutamate synthase
I6K11_RS11730	COG0070	glutamate synthase
I6K11_RS11730	COG0069	glutamate synthase activity
I6K11_RS11735	COG0493	'glutamate synthase
I6K11_RS11740	COG4804	nuclease activity
I6K11_RS11745	COG2731	YhcH YjgK YiaL family protein
I6K11_RS11775	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K11_RS11780	COG2969	positive regulation of protein catabolic process
I6K11_RS11785	COG0625	glutathione transferase activity
I6K11_RS11800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K11_RS11805	COG3105	Protein conserved in bacteria
I6K11_RS11810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K11_RS11815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K11_RS11835	COG2732	(Barnase) inhibitor
I6K11_RS11855	COG0583	DNA-binding transcription factor activity
I6K11_RS11860	COG0312	modulator of DNA gyrase
I6K11_RS11865	COG3164	Protein of unknown function
I6K11_RS11870	COG1530	ribonuclease E activity
I6K11_RS11880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K11_RS11885	COG1792	Involved in formation and maintenance of cell shape
I6K11_RS11890	COG1077	Cell shape determining protein MreB Mrl
I6K11_RS11895	COG2199	diguanylate cyclase activity
I6K11_RS11895	COG2200	EAL domain
I6K11_RS11900	COG0604	alcohol dehydrogenase
I6K11_RS11905	COG0511	ligase activity, forming carbon-carbon bonds
I6K11_RS11910	COG0439	Biotin carboxylase
I6K11_RS11915	COG3924	membrane
I6K11_RS11920	COG4145	pantothenate transmembrane transporter activity
I6K11_RS11930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K11_RS11940	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K11_RS11950	COG1309	transcriptional regulator
I6K11_RS11955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS11960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K11_RS11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS11975	COG4597	amino acid ABC transporter
I6K11_RS11980	COG0765	amino acid transport
I6K11_RS11985	COG1126	abc transporter atp-binding protein
I6K11_RS12025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K11_RS12045	COG0551	DNA topoisomerase type I activity
I6K11_RS12055	COG0758	DNA mediated transformation
I6K11_RS12075	COG0569	domain protein
I6K11_RS12085	COG3036	rescue of stalled ribosome
I6K11_RS12090	COG0789	Transcriptional regulator
I6K11_RS12130	COG0201	protein transport
I6K11_RS12220	COG0089	rRNA binding
I6K11_RS12290	COG2964	Protein conserved in bacteria
I6K11_RS12295	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K11_RS12305	COG1047	Peptidyl-prolyl cis-trans
I6K11_RS12310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K11_RS12325	COG0488	(ABC) transporter
I6K11_RS12330	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K11_RS12340	COG3954	Phosphoribulokinase
I6K11_RS12345	COG1765	OsmC-like protein
I6K11_RS12350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K11_RS12355	COG1289	transmembrane transporter activity
I6K11_RS12360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K11_RS12365	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K11_RS12370	COG2184	nucleotidyltransferase activity
I6K11_RS12380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K11_RS12390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K11_RS12395	COG2146	nitrite reductase [NAD(P)H] activity
I6K11_RS12400	COG2116	formate transmembrane transporter activity
I6K11_RS12415	COG0626	cystathionine gamma-synthase activity
I6K11_RS12430	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K11_RS12435	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6K11_RS12440	COG3457	Alanine racemase
I6K11_RS12450	COG2188	Transcriptional regulator
I6K11_RS12455	COG0180	Tryptophanyl-tRNA synthetase
I6K11_RS12460	COG0546	phosphoglycolate phosphatase activity
I6K11_RS12465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K11_RS12470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K11_RS12475	COG3266	domain, Protein
I6K11_RS12490	COG4796	Type ii and iii secretion system protein
I6K11_RS12505	COG3166	PFAM Fimbrial assembly family protein
I6K11_RS12510	COG4972	Pilus assembly protein
I6K11_RS12515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K11_RS12520	COG0494	nUDIX hydrolase
I6K11_RS12530	COG1011	Hydrolase
I6K11_RS12535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K11_RS12545	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K11_RS12575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K11_RS12580	COG2183	response to ionizing radiation
I6K11_RS12585	COG1918	ferrous iron import across plasma membrane
I6K11_RS12590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6K11_RS12600	COG5464	transposase or invertase
I6K11_RS12610	COG1040	competence protein
I6K11_RS12620	COG2610	gluconate transmembrane transporter activity
I6K11_RS12625	COG1640	4-alpha-glucanotransferase
I6K11_RS12630	COG0058	SHG alpha-glucan phosphorylase activity
I6K11_RS12645	COG1690	Belongs to the RtcB family
I6K11_RS12650	COG4650	regulator
I6K11_RS12655	COG1349	DNA-binding transcription factor activity
I6K11_RS12670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K11_RS12690	COG0058	SHG alpha-glucan phosphorylase activity
I6K11_RS12710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K11_RS12715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K11_RS12720	COG2095	MarC family integral membrane protein
I6K11_RS12725	COG2610	gluconate transmembrane transporter activity
I6K11_RS12730	COG3265	gluconokinase activity
I6K11_RS12735	COG1609	Transcriptional regulator
I6K11_RS12740	COG1741	Belongs to the pirin family
I6K11_RS12745	COG0673	inositol 2-dehydrogenase activity
I6K11_RS12750	COG1247	-acetyltransferase
I6K11_RS12755	COG3157	Type VI secretion system effector, Hcp
I6K11_RS12775	COG0405	Gamma-glutamyltransferase
I6K11_RS12785	COG0584	glycerophosphoryl diester phosphodiesterase
I6K11_RS12800	COG1175	transmembrane transport
I6K11_RS12805	COG1653	transport
I6K11_RS12810	COG0410	ABC transporter
I6K11_RS12815	COG0411	ABC transporter
I6K11_RS12820	COG4177	L-phenylalanine transmembrane transporter activity
I6K11_RS12825	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS12830	COG0683	leucine binding
I6K11_RS12835	COG0456	acetyltransferase
I6K11_RS12840	COG0683	leucine binding
I6K11_RS12845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K11_RS12850	COG2177	Part of the ABC transporter FtsEX involved in
I6K11_RS12855	COG2884	Cell division ATP-binding protein ftsE
I6K11_RS12860	COG0552	protein localization to endoplasmic reticulum
I6K11_RS12865	COG0742	ribosomal rna small subunit methyltransferase
I6K11_RS12870	COG3776	membrane
I6K11_RS12880	COG3714	YhhN family
I6K11_RS12895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K11_RS12910	COG0628	permease
I6K11_RS12915	COG2091	lysine biosynthetic process via aminoadipic acid
I6K11_RS12920	COG0747	negative chemotaxis
I6K11_RS12925	COG0601	transmembrane transport
I6K11_RS12930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K11_RS12950	COG3209	COG3209 Rhs family protein
I6K11_RS12970	COG3209	COG3209 Rhs family protein
I6K11_RS12980	COG1413	lyase activity
I6K11_RS13000	COG0842	Transport permease protein
I6K11_RS13005	COG0842	Transport permease protein
I6K11_RS13005	COG1129	ABC transporter
I6K11_RS13010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS13030	COG2081	HI0933 family
I6K11_RS13035	COG0306	phosphate transporter
I6K11_RS13045	COG0589	response to stress
I6K11_RS13050	COG3104	oligopeptide transport
I6K11_RS13060	COG0339	signal peptide processing
I6K11_RS13065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K11_RS13070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K11_RS13080	COG0640	Transcriptional regulator
I6K11_RS13085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K11_RS13090	COG1393	Belongs to the ArsC family
I6K11_RS13110	COG3065	identical protein binding
I6K11_RS13115	COG2197	response regulator
I6K11_RS13120	COG3720	iron ion transport
I6K11_RS13125	COG4771	TonB-dependent receptor
I6K11_RS13130	COG4558	Periplasmic binding protein
I6K11_RS13140	COG3721	Heme iron utilization protein
I6K11_RS13150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS13160	COG1285	pathogenesis
I6K11_RS13175	COG3247	response to pH
I6K11_RS13180	COG2771	luxR family
I6K11_RS13190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS13195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K11_RS13200	COG2207	Transcriptional regulator
I6K11_RS13210	COG0076	glutamate decarboxylase activity
I6K11_RS13215	COG1858	cytochrome C peroxidase
I6K11_RS13225	COG2197	response regulator
I6K11_RS13230	COG0583	DNA-binding transcription factor activity
I6K11_RS13235	COG1295	ribonuclease BN
I6K11_RS13240	COG0477	Major facilitator Superfamily
I6K11_RS13245	COG2982	Protein involved in outer membrane biogenesis
I6K11_RS13250	COG2200	EAL domain
I6K11_RS13260	COG0612	Peptidase, M16
I6K11_RS13270	COG2199	diguanylate cyclase activity
I6K11_RS13270	COG2200	EAL domain
I6K11_RS13275	COG3118	belongs to the thioredoxin family
I6K11_RS13275	COG0457	Tetratricopeptide repeat
I6K11_RS13280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K11_RS13285	COG1215	transferase activity, transferring glycosyl groups
I6K11_RS13290	COG1215	transferase activity, transferring glycosyl groups
I6K11_RS13315	COG2194	sulfuric ester hydrolase activity
I6K11_RS13335	COG0814	amino acid
I6K11_RS13340	COG4608	Belongs to the ABC transporter superfamily
I6K11_RS13345	COG0444	Belongs to the ABC transporter superfamily
I6K11_RS13350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K11_RS13355	COG0601	transmembrane transport
I6K11_RS13360	COG0747	negative chemotaxis
I6K11_RS13375	COG2194	sulfuric ester hydrolase activity
I6K11_RS13380	COG2223	nitrite transmembrane transporter activity
I6K11_RS13385	COG5571	outer membrane autotransporter
I6K11_RS13390	COG2818	Glycosylase
I6K11_RS13395	COG0456	acetyltransferase
I6K11_RS13400	COG0243	molybdopterin cofactor binding
I6K11_RS13405	COG2885	chlorophyll binding
I6K11_RS13420	COG2944	sequence-specific DNA binding
I6K11_RS13425	COG1278	Cold shock
I6K11_RS13455	COG3274	enterobacterial common antigen metabolic process
I6K11_RS13460	COG4682	membrane
I6K11_RS13465	COG4682	membrane
I6K11_RS13470	COG1070	Carbohydrate kinase
I6K11_RS13480	COG4213	ABC transporter substrate-binding protein
I6K11_RS13490	COG4214	carbohydrate transport
I6K11_RS13495	COG1609	Transcriptional regulator
I6K11_RS13495	COG2207	Transcriptional regulator
I6K11_RS13500	COG2992	FlgJ-related protein
I6K11_RS13505	COG0366	Alpha amylase catalytic
I6K11_RS13510	COG3977	Valine--pyruvate aminotransferase
I6K11_RS13515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K11_RS13520	COG1414	Transcriptional regulator
I6K11_RS13530	COG2731	YhcH YjgK YiaL family protein
I6K11_RS13535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K11_RS13540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K11_RS13545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K11_RS13550	COG1070	Carbohydrate kinase
I6K11_RS13555	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K11_RS13560	COG3623	hexulose-6-phosphate isomerase
I6K11_RS13565	COG0235	Class ii aldolase
I6K11_RS13575	COG2211	Major facilitator Superfamily
I6K11_RS13585	COG3713	MltA-interacting MipA family protein
I6K11_RS13590	COG0583	DNA-binding transcription factor activity
I6K11_RS13595	COG1566	PFAM secretion protein HlyD family protein
I6K11_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS13615	COG1454	alcohol dehydrogenase
I6K11_RS13620	COG3276	selenocysteine insertion sequence binding
I6K11_RS13630	COG0625	glutathione transferase activity
I6K11_RS13635	COG1566	PFAM secretion protein HlyD family protein
I6K11_RS13645	COG2213	PTS system mannitol-specific
I6K11_RS13645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS13655	COG3722	fumarate hydratase activity
I6K11_RS13675	COG5295	Hep Hag repeat protein
I6K11_RS13680	COG1620	l-lactate permease
I6K11_RS13685	COG2186	Transcriptional regulator
I6K11_RS13695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K11_RS13700	COG1045	serine acetyltransferase
I6K11_RS13715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K11_RS13720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K11_RS13730	COG4942	peptidase
I6K11_RS13735	COG2861	carbohydrate metabolic process
I6K11_RS13740	COG1216	Glycosyl transferase, family 2
I6K11_RS13750	COG0156	8-amino-7-oxononanoate synthase activity
I6K11_RS13760	COG0859	PFAM glycosyl transferase family 9
I6K11_RS13765	COG0859	PFAM glycosyl transferase family 9
I6K11_RS13780	COG1442	glycosyl transferase family 8
I6K11_RS13785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K11_RS13800	COG0515	serine threonine protein kinase
I6K11_RS13805	COG0438	transferase activity, transferring glycosyl groups
I6K11_RS13810	COG0859	PFAM glycosyl transferase family 9
I6K11_RS13815	COG1519	Transferase
I6K11_RS13825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K11_RS13845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K11_RS13875	COG1561	YicC-like family, N-terminal region
I6K11_RS13880	COG3645	SOS response
I6K11_RS13885	COG2860	membrane
I6K11_RS13895	COG0194	GDP metabolic process
I6K11_RS13905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K11_RS13910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K11_RS13915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K11_RS13920	COG0786	glutamate:sodium symporter activity
I6K11_RS13925	COG2233	PERMEase
I6K11_RS13930	COG2982	Protein involved in outer membrane biogenesis
I6K11_RS13940	COG1940	carbohydrate kinase activity
I6K11_RS13955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS13955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS13960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS13965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS13965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS13965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS13970	COG3711	transcriptional antiterminator
I6K11_RS13975	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K11_RS13980	COG2211	Major facilitator Superfamily
I6K11_RS13990	COG0582	viral genome integration into host DNA
I6K11_RS14000	COG1609	Transcriptional regulator
I6K11_RS14005	COG2271	Major facilitator Superfamily
I6K11_RS14020	COG2814	Major facilitator Superfamily
I6K11_RS14025	COG0697	spore germination
I6K11_RS14030	COG1464	Belongs to the NlpA lipoprotein family
I6K11_RS14040	COG0457	Tetratricopeptide repeat
I6K11_RS14065	COG4932	domain protein
I6K11_RS14065	COG2373	Large extracellular alpha-helical protein
I6K11_RS14065	COG1388	LysM domain
I6K11_RS14090	COG2252	PERMEase
I6K11_RS14100	COG2271	Major facilitator Superfamily
I6K11_RS14105	COG2271	Major facilitator Superfamily
I6K11_RS14110	COG3851	Histidine kinase
I6K11_RS14115	COG2197	response regulator
I6K11_RS14130	COG0440	acetolactate synthase activity
I6K11_RS14135	COG0028	Belongs to the TPP enzyme family
I6K11_RS14150	COG2814	Major facilitator Superfamily
I6K11_RS14155	COG0641	radical SAM
I6K11_RS14165	COG2149	membrane
I6K11_RS14170	COG3119	arylsulfatase activity
I6K11_RS14175	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K11_RS14180	COG2207	Transcriptional regulator
I6K11_RS14195	COG2188	Transcriptional regulator
I6K11_RS14215	COG5645	(Lipo)protein
I6K11_RS14220	COG0823	Involved in the tonB-independent uptake of proteins
I6K11_RS14225	COG0644	oxidoreductase
I6K11_RS14230	COG2271	Major facilitator Superfamily
I6K11_RS14240	COG0800	Aldolase
I6K11_RS14245	COG3734	2-keto-3-deoxy-galactonokinase
I6K11_RS14250	COG2186	Transcriptional regulator
I6K11_RS14260	COG0561	phosphatase activity
I6K11_RS14265	COG3753	Protein conserved in bacteria
I6K11_RS14270	COG0187	DNA topoisomerase II activity
I6K11_RS14280	COG0592	DNA-directed DNA polymerase activity
I6K11_RS14335	COG0814	amino acid
I6K11_RS14350	COG2091	lysine biosynthetic process via aminoadipic acid
I6K11_RS14355	COG0431	NADPH-dependent FMN reductase
I6K11_RS14360	COG2252	PERMEase
I6K11_RS14365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K11_RS14390	COG0704	Plays a role in the regulation of phosphate uptake
I6K11_RS14395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K11_RS14400	COG0581	inorganic phosphate transmembrane transporter activity
I6K11_RS14405	COG0573	inorganic phosphate transmembrane transporter activity
I6K11_RS14410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K11_RS14465	COG3312	ion transport
I6K11_RS14480	COG0716	FMN binding
I6K11_RS14485	COG1522	sequence-specific DNA binding
I6K11_RS14520	COG1129	ABC transporter
I6K11_RS14525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS14530	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS14535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS14540	COG1609	Transcriptional regulator
I6K11_RS14545	COG0477	Major facilitator Superfamily
I6K11_RS14550	COG2186	Transcriptional regulator
I6K11_RS14590	COG3085	chromosome segregation
I6K11_RS14595	COG0606	chelatase, subunit chli
I6K11_RS14615	COG3978	acetolactate synthase activity
I6K11_RS14620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K11_RS14630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K11_RS14645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K11_RS14650	COG3692	DNA binding
I6K11_RS14655	COG0210	DNA helicase
I6K11_RS14670	COG3118	belongs to the thioredoxin family
I6K11_RS14680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K11_RS14685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K11_RS14690	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K11_RS14695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K11_RS14700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K11_RS14705	COG0456	acetyltransferase
I6K11_RS14710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K11_RS14715	COG2244	polysaccharide biosynthetic process
I6K11_RS14735	COG1113	amino acid transport
I6K11_RS14760	COG0641	radical SAM
I6K11_RS14765	COG3119	arylsulfatase activity
I6K11_RS14770	COG3071	HemY protein
I6K11_RS14775	COG2959	enzyme of heme biosynthesis
I6K11_RS14780	COG1587	Uroporphyrinogen-III synthase
I6K11_RS14790	COG3072	Adenylate cyclase
I6K11_RS14805	COG5567	small periplasmic lipoprotein
I6K11_RS14815	COG3159	Protein conserved in bacteria
I6K11_RS14825	COG1011	Hydrolase
I6K11_RS14830	COG0210	DNA helicase
I6K11_RS14835	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6K11_RS14840	COG3698	Phosphodiester glycosidase
I6K11_RS14845	COG0598	Magnesium transport protein CorA
I6K11_RS14860	COG2962	Rard protein
I6K11_RS14865	COG2050	protein possibly involved in aromatic compounds catabolism
I6K11_RS14870	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6K11_RS14875	COG0514	ATP-dependent DNA helicase (RecQ)
I6K11_RS14880	COG1280	lysine exporter protein (LysE YggA)
I6K11_RS14885	COG1280	lysine exporter protein (LysE YggA)
I6K11_RS14890	COG2267	carboxylic ester hydrolase activity
I6K11_RS14895	COG0561	phosphatase activity
I6K11_RS14900	COG0697	spore germination
I6K11_RS14905	COG0583	DNA-binding transcription factor activity
I6K11_RS14920	COG3157	Type VI secretion system effector, Hcp
I6K11_RS14925	COG0412	Dienelactone hydrolase
I6K11_RS14930	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6K11_RS14935	COG1322	Protein conserved in bacteria
I6K11_RS14945	COG3165	ubiquinone biosynthetic process from chorismate
I6K11_RS14955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K11_RS14965	COG0805	protein transport
I6K11_RS14975	COG0250	Participates in transcription elongation, termination and antitermination
I6K11_RS14980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K11_RS14985	COG0543	2 iron, 2 sulfur cluster binding
I6K11_RS15005	COG1739	Uncharacterized protein family UPF0029
I6K11_RS15010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K11_RS15015	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K11_RS15050	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K11_RS15055	COG0746	molybdenum cofactor guanylyltransferase activity
I6K11_RS15060	COG3084	Protein conserved in bacteria
I6K11_RS15065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K11_RS15070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K11_RS15080	COG5339	Protein conserved in bacteria
I6K11_RS15085	COG0204	Acyl-transferase
I6K11_RS15090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K11_RS15090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K11_RS15105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K11_RS15115	COG2204	response regulator
I6K11_RS15120	COG3852	Histidine kinase
I6K11_RS15125	COG0174	glutamine synthetase
I6K11_RS15130	COG1217	gtp-binding protein TYPA
I6K11_RS15140	COG2188	Transcriptional regulator
I6K11_RS15145	COG1082	Xylose isomerase domain protein TIM barrel
I6K11_RS15150	COG2271	Major facilitator Superfamily
I6K11_RS15155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K11_RS15160	COG2211	Major facilitator Superfamily
I6K11_RS15165	COG2211	Major facilitator Superfamily
I6K11_RS15170	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K11_RS15180	COG2017	converts alpha-aldose to the beta-anomer
I6K11_RS15185	COG2942	2-epimerase
I6K11_RS15190	COG3684	Belongs to the aldolase LacD family
I6K11_RS15195	COG2084	Dehydrogenase
I6K11_RS15200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS15205	COG1349	DNA-binding transcription factor activity
I6K11_RS15210	COG1011	Hydrolase
I6K11_RS15225	COG0456	acetyltransferase
I6K11_RS15235	COG0657	acetylesterase activity
I6K11_RS15240	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K11_RS15260	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K11_RS15265	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K11_RS15275	COG2864	formate dehydrogenase
I6K11_RS15280	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS15300	COG3711	transcriptional antiterminator
I6K11_RS15300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS15305	COG1363	Peptidase, m42
I6K11_RS15310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS15310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS15315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS15360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K11_RS15370	COG2258	MOSC domain
I6K11_RS15375	COG2205	protein histidine kinase activity
I6K11_RS15380	COG0745	RESPONSE REGULATOR receiver
I6K11_RS15385	COG3678	ATP-independent chaperone mediated protein folding
I6K11_RS15400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K11_RS15420	COG3152	Membrane
I6K11_RS15425	COG3691	Protein conserved in bacteria
I6K11_RS15430	COG0589	response to stress
I6K11_RS15440	COG1494	fructose-1,6-bisphosphatase
I6K11_RS15450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K11_RS15465	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K11_RS15480	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K11_RS15485	COG1609	Transcriptional regulator
I6K11_RS15490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K11_RS15500	COG3209	COG3209 Rhs family protein
I6K11_RS15515	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K11_RS15525	COG0626	cystathionine gamma-synthase activity
I6K11_RS15530	COG0527	aspartate kinase activity
I6K11_RS15530	COG0460	homoserine dehydrogenase
I6K11_RS15540	COG0737	Belongs to the 5'-nucleotidase family
I6K11_RS15545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K11_RS15555	COG0697	spore germination
I6K11_RS15560	COG3738	Protein conserved in bacteria
I6K11_RS15565	COG0371	Dehydrogenase
I6K11_RS15570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K11_RS15575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K11_RS15575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS15575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS15580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS15585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS15590	COG1882	Formate acetyltransferase
I6K11_RS15595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K11_RS15600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS15605	COG2207	Transcriptional regulator
I6K11_RS15610	COG2194	sulfuric ester hydrolase activity
I6K11_RS15625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K11_RS15640	COG0583	DNA-binding transcription factor activity
I6K11_RS15650	COG1309	transcriptional regulator
I6K11_RS15665	COG4206	TonB-dependent receptor
I6K11_RS15705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K11_RS15705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K11_RS15740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K11_RS15745	COG0250	Participates in transcription elongation, termination and antitermination
I6K11_RS15785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K11_RS15795	COG2104	thiamine diphosphate biosynthetic process
I6K11_RS15800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K11_RS15835	COG3068	Protein conserved in bacteria
I6K11_RS15850	COG3678	ATP-independent chaperone mediated protein folding
I6K11_RS15855	COG4191	Histidine kinase
I6K11_RS15860	COG2204	response regulator
I6K11_RS15865	COG0151	Belongs to the GarS family
I6K11_RS15895	COG0456	acetyltransferase
I6K11_RS15905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K11_RS15910	COG2224	Isocitrate lyase
I6K11_RS15925	COG1414	Transcriptional regulator
I6K11_RS15930	COG1410	methionine synthase
I6K11_RS15930	COG0646	methionine synthase
I6K11_RS15935	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K11_RS15985	COG1187	pseudouridine synthase activity
I6K11_RS15995	COG0527	aspartate kinase activity
I6K11_RS16020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K11_RS16035	COG3833	ABC-type maltose transport systems, permease component
I6K11_RS16040	COG1175	transmembrane transport
I6K11_RS16045	COG2182	Extracellular solute-binding protein
I6K11_RS16050	COG3842	ATPase activity
I6K11_RS16095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K11_RS16105	COG0534	Mate efflux family protein
I6K11_RS16110	COG3237	CsbD-like
I6K11_RS16115	COG0735	belongs to the Fur family
I6K11_RS16125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K11_RS16135	COG0604	alcohol dehydrogenase
I6K11_RS16140	COG0305	Participates in initiation and elongation during chromosome replication
I6K11_RS16145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K11_RS16150	COG1448	Aminotransferase
I6K11_RS16160	COG3700	Belongs to the class B bacterial acid phosphatase family
I6K11_RS16165	COG0432	Pfam Uncharacterised protein family UPF0047
I6K11_RS16170	COG2315	Protein conserved in bacteria
I6K11_RS16175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K11_RS16180	COG0629	single-stranded DNA binding
I6K11_RS16205	COG2207	Transcriptional regulator
I6K11_RS16210	COG0789	Transcriptional regulator
I6K11_RS16215	COG2252	PERMEase
I6K11_RS16220	COG0025	NhaP-type Na H and K H
I6K11_RS16225	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K11_RS16235	COG3162	membrane
I6K11_RS16240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K11_RS16250	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6K11_RS16255	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS16260	COG3301	Polysulphide reductase, NrfD
I6K11_RS16265	COG1138	Cytochrome C-type biogenesis protein
I6K11_RS16270	COG3088	subunit of a heme lyase
I6K11_RS16275	COG4235	cytochrome complex assembly
I6K11_RS16280	COG1301	dicarboxylic acid transport
I6K11_RS16285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K11_RS16300	COG1289	transmembrane transporter activity
I6K11_RS16305	COG1566	PFAM secretion protein HlyD family protein
I6K11_RS16315	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K11_RS16320	COG0698	ribose 5-phosphate isomerase
I6K11_RS16330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K11_RS16335	COG0456	acetyltransferase
I6K11_RS16345	COG3454	Phosphonate metabolism
I6K11_RS16350	COG4778	phosphonate C-P lyase system protein PhnL
I6K11_RS16355	COG4107	phosphonate C-P lyase system protein PhnK
I6K11_RS16360	COG3627	carbon phosphorus lyase activity
I6K11_RS16365	COG3626	phosphonate metabolism
I6K11_RS16370	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K11_RS16375	COG3624	Phosphonate C-P lyase system protein PhnG
I6K11_RS16380	COG2188	Transcriptional regulator
I6K11_RS16385	COG3639	organic phosphonate transmembrane transporter activity
I6K11_RS16390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K11_RS16400	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K11_RS16405	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K11_RS16410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6K11_RS16420	COG0477	Major facilitator Superfamily
I6K11_RS16430	COG0642	Histidine kinase
I6K11_RS16435	COG0745	RESPONSE REGULATOR receiver
I6K11_RS16440	COG2194	sulfuric ester hydrolase activity
I6K11_RS16445	COG0531	amino acid
I6K11_RS16450	COG2207	Transcriptional regulator
I6K11_RS16455	COG1982	Orn Lys Arg decarboxylase major
I6K11_RS16460	COG2169	Transcriptional regulator
I6K11_RS16465	COG1486	melibiose metabolic process
I6K11_RS16470	COG2211	Major facilitator Superfamily
I6K11_RS16475	COG3647	Membrane
I6K11_RS16480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS16480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS16485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K11_RS16490	COG4565	transcriptional regulatory protein
I6K11_RS16495	COG3290	protein histidine kinase activity
I6K11_RS16500	COG3592	Divergent 4Fe-4S mono-cluster
I6K11_RS16505	COG2388	GCN5-related N-acetyl-transferase
I6K11_RS16520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K11_RS16525	COG3104	oligopeptide transport
I6K11_RS16530	COG1982	Orn Lys Arg decarboxylase major
I6K11_RS16535	COG0531	amino acid
I6K11_RS16540	COG3710	Transcriptional regulator
I6K11_RS16575	COG2003	Belongs to the UPF0758 family
I6K11_RS16600	COG2378	regulation of single-species biofilm formation
I6K11_RS16605	COG3596	GTP binding
I6K11_RS16625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K11_RS16630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS16635	COG2313	pseudouridylate synthase activity
I6K11_RS16640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K11_RS16645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS16645	COG1522	sequence-specific DNA binding
I6K11_RS16695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6K11_RS16700	COG2207	Transcriptional regulator
I6K11_RS16705	COG2972	Histidine kinase
I6K11_RS16725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K11_RS16730	COG1882	Formate acetyltransferase
I6K11_RS16735	COG0693	protein deglycase activity
I6K11_RS16745	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS16780	COG4820	ethanolamine utilization protein (EutJ)
I6K11_RS16785	COG4869	propanediol catabolic process
I6K11_RS16840	COG3969	phosphoadenosine phosphosulfate
I6K11_RS16845	COG1475	DNA binding
I6K11_RS16875	COG3344	reverse transcriptase
I6K11_RS16890	COG0604	alcohol dehydrogenase
I6K11_RS16900	COG0531	amino acid
I6K11_RS16905	COG1982	Orn Lys Arg decarboxylase major
I6K11_RS16910	COG0531	amino acid
I6K11_RS16940	COG0582	viral genome integration into host DNA
I6K11_RS16950	COG1309	transcriptional regulator
I6K11_RS16955	COG4232	protein-disulfide reductase activity
I6K11_RS16965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K11_RS16970	COG1027	Aspartate ammonia-lyase
I6K11_RS16975	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K11_RS16980	COG0531	amino acid
I6K11_RS17005	COG1509	lysine 2,3-aminomutase activity
I6K11_RS17015	COG5510	response to toxic substance
I6K11_RS17020	COG5510	response to toxic substance
I6K11_RS17030	COG2076	Multidrug Resistance protein
I6K11_RS17035	COG3040	lipid binding
I6K11_RS17040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K11_RS17055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K11_RS17060	COG1053	succinate dehydrogenase
I6K11_RS17070	COG0531	amino acid
I6K11_RS17075	COG1511	domain protein
I6K11_RS17075	COG3264	Mechanosensitive ion channel
I6K11_RS17115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K11_RS17120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K11_RS17120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K11_RS17125	COG0802	atpase or kinase
I6K11_RS17130	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K11_RS17150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K11_RS17155	COG0330	HflC and HflK could
I6K11_RS17160	COG0330	HflC and HflK could
I6K11_RS17165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K11_RS17180	COG0557	exoribonuclease II activity
I6K11_RS17185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K11_RS17190	COG3789	protein conserved in bacteria
I6K11_RS17195	COG1842	Phage shock protein A
I6K11_RS17205	COG3766	membrane
I6K11_RS17215	COG0754	glutathionylspermidine amidase activity
I6K11_RS17220	COG1960	acyl-CoA dehydrogenase activity
I6K11_RS17230	COG3650	response to hydrogen peroxide
I6K11_RS17235	COG1073	alpha beta
I6K11_RS17250	COG3037	sugar-specific permease SgaT UlaA
I6K11_RS17255	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K11_RS17295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K11_RS17320	COG0675	Transposase, IS605 OrfB family
I6K11_RS17330	COG3061	Opacity-associated protein A
I6K11_RS17335	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K11_RS17340	COG1113	amino acid transport
I6K11_RS17350	COG0697	spore germination
I6K11_RS17355	COG0702	epimerase
I6K11_RS17360	COG1733	regulation of RNA biosynthetic process
I6K11_RS17365	COG0737	Belongs to the 5'-nucleotidase family
I6K11_RS17370	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6K11_RS17390	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K11_RS17400	COG1253	flavin adenine dinucleotide binding
I6K11_RS17410	COG0729	surface antigen
I6K11_RS17415	COG2911	Protein conserved in bacteria
I6K11_RS17420	COG2105	PFAM AIG2 family protein
I6K11_RS17425	COG2336	PFAM SpoVT AbrB
I6K11_RS17430	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6K11_RS17435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K11_RS17440	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS17445	COG1129	ABC transporter
I6K11_RS17450	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS17455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS17465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K11_RS17475	COG0312	modulator of DNA gyrase
I6K11_RS17480	COG3783	Cytochrome b(562)
I6K11_RS17485	COG3077	Addiction module antitoxin, RelB DinJ family
I6K11_RS17490	COG2026	Addiction module toxin, RelE StbE family
I6K11_RS17495	COG0602	queuosine metabolic process
I6K11_RS17500	COG1328	CTP reductase activity
I6K11_RS17505	COG0366	Alpha amylase catalytic
I6K11_RS17510	COG1263	PTS System
I6K11_RS17510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS17515	COG1609	Transcriptional regulator
I6K11_RS17525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K11_RS17530	COG0251	oxidation-reduction process
I6K11_RS17550	COG0251	oxidation-reduction process
I6K11_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS17560	COG1309	transcriptional regulator
I6K11_RS17565	COG2731	YhcH YjgK YiaL family protein
I6K11_RS17580	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6K11_RS17585	COG0456	acetyltransferase
I6K11_RS17590	COG4269	membrane
I6K11_RS17595	COG0525	valine-tRNA ligase activity
I6K11_RS17600	COG2927	DNA polymerase III (CHI subunit)
I6K11_RS17610	COG0795	lipopolysaccharide-transporting ATPase activity
I6K11_RS17615	COG0795	lipopolysaccharide-transporting ATPase activity
I6K11_RS17620	COG0433	COG0433 Predicted ATPase
I6K11_RS17625	COG1609	Transcriptional regulator
I6K11_RS17630	COG2610	gluconate transmembrane transporter activity
I6K11_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS17640	COG1063	alcohol dehydrogenase
I6K11_RS17645	COG3265	gluconokinase activity
I6K11_RS17650	COG1064	alcohol dehydrogenase
I6K11_RS17675	COG3385	transposase activity
I6K11_RS17680	COG2814	Major facilitator Superfamily
I6K11_RS17685	COG0673	inositol 2-dehydrogenase activity
I6K11_RS17710	COG3344	reverse transcriptase
I6K11_RS17725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K11_RS17740	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6K11_RS17745	COG1120	ATPase activity
I6K11_RS17750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS17755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS17760	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K11_RS17765	COG4772	TonB-dependent receptor
I6K11_RS17770	COG3712	iron ion homeostasis
I6K11_RS17775	COG1595	DNA-templated transcription, initiation
I6K11_RS17810	COG4372	Transposase
I6K11_RS17815	COG3436	PFAM IS66 Orf2 family protein
I6K11_RS17850	COG4983	Phage plasmid primase, P4 family domain protein
I6K11_RS17860	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS17880	COG2003	Belongs to the UPF0758 family
I6K11_RS17920	COG2390	Transcriptional regulator
I6K11_RS17925	COG2610	gluconate transmembrane transporter activity
I6K11_RS17930	COG0129	dihydroxy-acid dehydratase activity
I6K11_RS17935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K11_RS17940	COG1414	Transcriptional regulator
I6K11_RS17945	COG1349	DNA-binding transcription factor activity
I6K11_RS17950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K11_RS17955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS17960	COG0434	BtpA family
I6K11_RS17965	COG3775	system Galactitol-specific IIC component
I6K11_RS17970	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K11_RS17975	COG1363	Peptidase, m42
I6K11_RS17990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K11_RS17995	COG3153	acetyltransferase
I6K11_RS18020	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6K11_RS18025	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K11_RS18030	COG0582	viral genome integration into host DNA
I6K11_RS18035	COG4974	Belongs to the 'phage' integrase family
I6K11_RS18040	COG3539	Fimbrial protein
I6K11_RS18045	COG3539	Fimbrial protein
I6K11_RS18050	COG3121	Chaperone
I6K11_RS18055	COG3188	usher protein
I6K11_RS18060	COG3539	Fimbrial protein
I6K11_RS18065	COG3539	Fimbrial protein
I6K11_RS18070	COG3539	Fimbrial protein
I6K11_RS18075	COG2610	gluconate transmembrane transporter activity
I6K11_RS18085	COG0246	Mannitol dehydrogenase
I6K11_RS18090	COG2186	Transcriptional regulator
I6K11_RS18110	COG0583	DNA-binding transcription factor activity
I6K11_RS18115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K11_RS18120	COG0700	Nucleoside recognition
I6K11_RS18125	COG3366	ferrous iron transmembrane transporter activity
I6K11_RS18135	COG0477	Major facilitator Superfamily
I6K11_RS18150	COG1924	4 iron, 4 sulfur cluster binding
I6K11_RS18155	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K11_RS18160	COG2733	membrane
I6K11_RS18170	COG5457	Domain of unknown function (DUF1127)
I6K11_RS18185	COG0732	type I restriction modification DNA specificity domain
I6K11_RS18190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K11_RS18195	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K11_RS18200	COG1715	Restriction endonuclease
I6K11_RS18205	COG0523	cobalamin synthesis protein
I6K11_RS18210	COG2879	small protein
I6K11_RS18215	COG1966	Carbon starvation protein
I6K11_RS18220	COG0840	transmembrane signaling receptor activity
I6K11_RS18225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K11_RS18235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K11_RS18240	COG0025	NhaP-type Na H and K H
I6K11_RS18245	COG1802	Transcriptional regulator
I6K11_RS18250	COG1063	alcohol dehydrogenase
I6K11_RS18265	COG1484	DNA-dependent DNA replication
I6K11_RS18280	COG2966	Psort location CytoplasmicMembrane, score
I6K11_RS18285	COG2197	response regulator
I6K11_RS18290	COG2197	response regulator
I6K11_RS18295	COG4114	ferric iron reductase
I6K11_RS18325	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K11_RS18330	COG0456	acetyltransferase
I6K11_RS18335	COG1011	Hydrolase
I6K11_RS18345	COG2823	Periplasmic or secreted lipoprotein
I6K11_RS18355	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K11_RS18360	COG0084	hydrolase, TatD family'
I6K11_RS18365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K11_RS18370	COG1328	CTP reductase activity
I6K11_RS18405	COG3726	membrane protein affecting hemolysin expression
I6K11_RS18410	COG0560	Phosphoserine phosphatase
I6K11_RS18415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K11_RS18420	COG1056	cytidyltransferase-related domain
I6K11_RS18420	COG3172	ATPase kinase involved in NAD metabolism
I6K11_RS18425	COG1902	pentaerythritol trinitrate reductase activity
I6K11_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS18450	COG0583	DNA-binding transcription factor activity
I6K11_RS18460	COG0488	(ABC) transporter
I6K11_RS18465	COG0741	lytic transglycosylase activity
I6K11_RS18485	COG2207	Transcriptional regulator
I6K11_RS18485	COG3708	Transcriptional regulator
I6K11_RS18490	COG3045	CreA protein
I6K11_RS18495	COG0745	RESPONSE REGULATOR receiver
I6K11_RS18500	COG2205	protein histidine kinase activity
I6K11_RS18505	COG4452	Inner membrane protein CreD
I6K11_RS18515	COG0745	RESPONSE REGULATOR receiver
I6K11_RS18525	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K11_RS18535	COG0527	aspartate kinase activity
I6K11_RS18535	COG0460	homoserine dehydrogenase
I6K11_RS18545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K11_RS18560	COG1115	amino acid carrier protein
I6K11_RS18570	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K11_RS18575	COG1584	GPR1 FUN34 yaaH family protein
I6K11_RS18580	COG4735	regulation of single-species biofilm formation
I6K11_RS18610	COG0583	DNA-binding transcription factor activity
I6K11_RS18620	COG3188	usher protein
I6K11_RS18625	COG3121	Chaperone
I6K11_RS18650	COG0196	riboflavin kinase activity
I6K11_RS18665	COG1047	Peptidyl-prolyl cis-trans
I6K11_RS18690	COG0505	Belongs to the CarA family
I6K11_RS18695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K11_RS18745	COG0644	oxidoreductase
I6K11_RS18755	COG2271	Major facilitator Superfamily
I6K11_RS18770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K11_RS18805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K11_RS18815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K11_RS18820	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K11_RS18830	COG0564	pseudouridine synthase activity
I6K11_RS18840	COG0417	DNA replication proofreading
I6K11_RS18845	COG0235	Class ii aldolase
I6K11_RS18860	COG4977	sequence-specific DNA binding
I6K11_RS18865	COG0586	Pfam SNARE associated Golgi protein
I6K11_RS18875	COG1178	ABC-type Fe3 transport system permease component
I6K11_RS18880	COG4143	(ABC) transporter
I6K11_RS18925	COG0583	DNA-binding transcription factor activity
I6K11_RS18935	COG0028	Belongs to the TPP enzyme family
I6K11_RS18940	COG0440	acetolactate synthase activity
I6K11_RS18950	COG1609	Transcriptional regulator
I6K11_RS18965	COG3116	cell division
I6K11_RS18970	COG0768	penicillin binding
I6K11_RS18975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K11_RS18980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K11_RS18995	COG0772	Belongs to the SEDS family
I6K11_RS19010	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K11_RS19015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K11_RS19020	COG0849	cell division
I6K11_RS19025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K11_RS19045	COG0494	nUDIX hydrolase
I6K11_RS19060	COG0237	dephospho-CoA kinase activity
I6K11_RS19075	COG1459	type II secretion system
I6K11_RS19080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K11_RS19085	COG4969	Belongs to the N-Me-Phe pilin family
I6K11_RS19090	COG0157	Belongs to the NadC ModD family
I6K11_RS19095	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K11_RS19100	COG3725	Membrane protein required for beta-lactamase induction
I6K11_RS19110	COG2186	Transcriptional regulator
I6K11_RS19115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K11_RS19120	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K11_RS19125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K11_RS19130	COG3064	Membrane
I6K11_RS19135	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6K11_RS19160	COG2132	Multicopper oxidase
I6K11_RS19165	COG4993	Dehydrogenase
I6K11_RS19170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K11_RS19175	COG0288	reversible hydration of carbon dioxide
I6K11_RS19180	COG1131	(ABC) transporter
I6K11_RS19185	COG0842	Transport permease protein
I6K11_RS19190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS19195	COG0726	polysaccharide deacetylase
I6K11_RS19205	COG5464	transposase or invertase
I6K11_RS19235	COG3121	Chaperone
I6K11_RS19240	COG3539	Fimbrial protein
I6K11_RS19245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K11_RS19250	COG0617	tRNA 3'-terminal CCA addition
I6K11_RS19255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K11_RS19260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K11_RS19270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K11_RS19275	COG1643	Atp-dependent helicase
I6K11_RS19280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K11_RS19285	COG4774	siderophore transport
I6K11_RS19290	COG1120	ATPase activity
I6K11_RS19295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K11_RS19300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS19325	COG2860	membrane
I6K11_RS19330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K11_RS19345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K11_RS19350	COG3835	regulator
I6K11_RS19370	COG0024	Methionine aminopeptidase
I6K11_RS19395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K11_RS19400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K11_RS19405	COG0575	Belongs to the CDS family
I6K11_RS19410	COG0750	zinc metalloprotease
I6K11_RS19420	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K11_RS19425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K11_RS19450	COG0587	DNA-directed DNA polymerase activity
I6K11_RS19460	COG1982	Orn Lys Arg decarboxylase major
I6K11_RS19465	COG0346	lactoylglutathione lyase activity
I6K11_RS19470	COG0037	tRNA processing
I6K11_RS19475	COG4568	rho-dependent transcription termination
I6K11_RS19485	COG4681	YaeQ
I6K11_RS19490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K11_RS19495	COG3015	lipoprotein NlpE involved in copper resistance
I6K11_RS19500	COG0791	NLP P60 protein
I6K11_RS19510	COG1720	tRNA m6t6A37 methyltransferase activity
I6K11_RS19520	COG1464	Belongs to the NlpA lipoprotein family
I6K11_RS19525	COG2011	ABC-type metal ion transport system permease component
I6K11_RS19530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K11_RS19535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K11_RS19570	COG0656	L-ascorbic acid biosynthetic process
I6K11_RS19575	COG0583	DNA-binding transcription factor activity
I6K11_RS19585	COG2226	methyltransferase
I6K11_RS19590	COG0741	lytic transglycosylase activity
I6K11_RS19590	COG1388	LysM domain
I6K11_RS19600	COG2226	methyltransferase
I6K11_RS19610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS19630	COG4104	PAAR repeat-containing protein
I6K11_RS19635	COG3157	Type VI secretion system effector, Hcp
I6K11_RS19725	COG3209	COG3209 Rhs family protein
I6K11_RS19745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K11_RS19755	COG1960	acyl-CoA dehydrogenase activity
I6K11_RS19765	COG0121	glutamine amidotransferase
I6K11_RS19770	COG3034	peptidoglycan biosynthetic process
I6K11_RS19775	COG0791	NLP P60 protein
I6K11_RS19800	COG2161	toxin-antitoxin pair type II binding
I6K11_RS19810	COG0454	-acetyltransferase
I6K11_RS19825	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K11_RS19905	COG0583	DNA-binding transcription factor activity
I6K11_RS19920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K11_RS19925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K11_RS19930	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K11_RS19935	COG2080	2 iron, 2 sulfur cluster binding
I6K11_RS19940	COG3477	response to acidic pH
I6K11_RS19945	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K11_RS20000	COG1902	pentaerythritol trinitrate reductase activity
I6K11_RS20005	COG1073	alpha beta
I6K11_RS20010	COG0583	DNA-binding transcription factor activity
I6K11_RS20020	COG0667	Aldo Keto reductase
I6K11_RS20025	COG0656	L-ascorbic acid biosynthetic process
I6K11_RS20030	COG1388	LysM domain
I6K11_RS20035	COG2207	Transcriptional regulator
I6K11_RS20035	COG3708	Transcriptional regulator
I6K11_RS20040	COG0656	L-ascorbic acid biosynthetic process
I6K11_RS20045	COG3059	membrane
I6K11_RS20055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K11_RS20060	COG2207	Transcriptional regulator
I6K11_RS20070	COG1139	Iron-sulfur cluster binding protein
I6K11_RS20075	COG1556	Lactate utilization protein
I6K11_RS20100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K11_RS20105	COG2771	luxR family
I6K11_RS20105	COG2200	EAL domain
I6K11_RS20110	COG0583	DNA-binding transcription factor activity
I6K11_RS20120	COG0666	response to abiotic stimulus
I6K11_RS20130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K11_RS20135	COG1304	FMN binding
I6K11_RS20140	COG0549	Belongs to the carbamate kinase family
I6K11_RS20145	COG0402	S-adenosylhomocysteine deaminase activity
I6K11_RS20155	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS20160	COG1129	ABC transporter
I6K11_RS20165	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K11_RS20175	COG1064	alcohol dehydrogenase
I6K11_RS20190	COG1280	lysine exporter protein (LysE YggA)
I6K11_RS20200	COG3829	transcription factor binding
I6K11_RS20205	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K11_RS20210	COG0372	Belongs to the citrate synthase family
I6K11_RS20215	COG2079	MmgE PrpD family protein
I6K11_RS20220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K11_RS20225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K11_RS20235	COG0583	DNA-binding transcription factor activity
I6K11_RS20240	COG0288	reversible hydration of carbon dioxide
I6K11_RS20250	COG2807	transmembrane transport
I6K11_RS20255	COG0110	maltose O-acetyltransferase activity
I6K11_RS20260	COG2223	nitrite transmembrane transporter activity
I6K11_RS20270	COG1609	Transcriptional regulator
I6K11_RS20275	COG1414	Transcriptional regulator
I6K11_RS20310	COG2814	Major facilitator Superfamily
I6K11_RS20315	COG3122	Protein conserved in bacteria
I6K11_RS20345	COG1215	transferase activity, transferring glycosyl groups
I6K11_RS20350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K11_RS20355	COG4521	taurine ABC transporter
I6K11_RS20360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K11_RS20365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K11_RS20370	COG2175	clavaminate synthase activity
I6K11_RS20375	COG0113	porphobilinogen synthase activity
I6K11_RS20380	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS20385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K11_RS20390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K11_RS20395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K11_RS20415	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K11_RS20430	COG1785	Belongs to the alkaline phosphatase family
I6K11_RS20440	COG3706	GGDEF domain
I6K11_RS20445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K11_RS20465	COG4126	flavin adenine dinucleotide binding
I6K11_RS20490	COG1940	carbohydrate kinase activity
I6K11_RS20500	COG2814	Major facilitator Superfamily
I6K11_RS20505	COG0419	ATPase involved in DNA repair
I6K11_RS20510	COG0420	3'-5' exonuclease activity
I6K11_RS20515	COG0745	RESPONSE REGULATOR receiver
I6K11_RS20520	COG5002	protein histidine kinase activity
I6K11_RS20525	COG1114	Component of the transport system for branched-chain amino acids
I6K11_RS20530	COG1113	amino acid transport
I6K11_RS20535	COG0366	Alpha amylase catalytic
I6K11_RS20560	COG1862	Preprotein translocase
I6K11_RS20565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K11_RS20570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K11_RS20580	COG1403	HNH endonuclease
I6K11_RS20585	COG3248	Nucleoside-binding outer membrane protein
I6K11_RS20600	COG0675	Transposase, IS605 OrfB family
I6K11_RS20615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K11_RS20615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K11_RS20630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K11_RS20635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K11_RS20645	COG0667	Aldo Keto reductase
I6K11_RS20655	COG0142	geranyltranstransferase activity
I6K11_RS20670	COG0693	protein deglycase activity
I6K11_RS20675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K11_RS20685	COG2814	Major facilitator Superfamily
I6K11_RS20695	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K11_RS20700	COG1845	cytochrome c oxidase, subunit III
I6K11_RS20705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K11_RS20710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K11_RS20715	COG2223	nitrite transmembrane transporter activity
I6K11_RS20720	COG3056	Lipoprotein
I6K11_RS20725	COG0271	Belongs to the BolA IbaG family
I6K11_RS20745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K11_RS20750	COG0776	regulation of translation
I6K11_RS20755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K11_RS20760	COG1555	photosystem II stabilization
I6K11_RS20765	COG0824	Thioesterase
I6K11_RS20780	COG0347	Belongs to the P(II) protein family
I6K11_RS20785	COG0004	ammonium transporteR
I6K11_RS20790	COG1946	Acyl-CoA thioesterase
I6K11_RS20795	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K11_RS20800	COG3695	enzyme binding
I6K11_RS20810	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K11_RS20815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K11_RS20825	COG0110	maltose O-acetyltransferase activity
I6K11_RS20840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K11_RS20845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS20850	COG1309	transcriptional regulator
I6K11_RS20855	COG1196	nuclear chromosome segregation
I6K11_RS20855	COG3264	Mechanosensitive ion channel
I6K11_RS20865	COG3923	Primosomal replication protein n
I6K11_RS20870	COG2832	Protein of unknown function (DUF454)
I6K11_RS20880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K11_RS20915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K11_RS20925	COG4651	solute:proton antiporter activity
I6K11_RS20925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K11_RS20930	COG2223	nitrite transmembrane transporter activity
I6K11_RS20935	COG0737	Belongs to the 5'-nucleotidase family
I6K11_RS20940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K11_RS20945	COG3735	TraB family
I6K11_RS20950	COG2217	Heavy metal translocating P-type atpase
I6K11_RS20960	COG0531	amino acid
I6K11_RS20985	COG0789	Transcriptional regulator
I6K11_RS21005	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K11_RS21010	COG0330	HflC and HflK could
I6K11_RS21015	COG4619	ABC transporter
I6K11_RS21020	COG0390	transport system, permease component
I6K11_RS21025	COG3118	belongs to the thioredoxin family
I6K11_RS21030	COG0300	oxidoreductase activity
I6K11_RS21035	COG2755	lipolytic protein G-D-S-L family
I6K11_RS21040	COG4181	ATPase activity
I6K11_RS21045	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K11_RS21050	COG3209	COG3209 Rhs family protein
I6K11_RS21075	COG0583	DNA-binding transcription factor activity
I6K11_RS21085	COG1414	Transcriptional regulator
I6K11_RS21090	COG3960	tartronate-semialdehyde synthase activity
I6K11_RS21095	COG3622	Belongs to the hyi family
I6K11_RS21100	COG2084	Dehydrogenase
I6K11_RS21105	COG1953	Uracil, thiamine, allantoin
I6K11_RS21115	COG2233	PERMEase
I6K11_RS21120	COG1929	Belongs to the glycerate kinase type-1 family
I6K11_RS21125	COG3257	ureidoglycine aminohydrolase activity
I6K11_RS21130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K11_RS21140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K11_RS21145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K11_RS21155	COG0549	Belongs to the carbamate kinase family
I6K11_RS21160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K11_RS21165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K11_RS21175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K11_RS21185	COG1988	membrane-bound metal-dependent
I6K11_RS21190	COG2501	S4 domain
I6K11_RS21200	COG3539	Fimbrial protein
I6K11_RS21205	COG3121	Chaperone
I6K11_RS21210	COG3188	usher protein
I6K11_RS21215	COG3539	Fimbrial protein
I6K11_RS21220	COG3539	Fimbrial protein
I6K11_RS21225	COG2197	response regulator
I6K11_RS21235	COG2207	Transcriptional regulator
I6K11_RS21245	COG4783	chaperone-mediated protein folding
I6K11_RS21255	COG5433	transposase activity
I6K11_RS21270	COG3209	COG3209 Rhs family protein
I6K11_RS21270	COG4104	PAAR repeat-containing protein
I6K11_RS21315	COG5002	protein histidine kinase activity
I6K11_RS21320	COG0745	RESPONSE REGULATOR receiver
I6K11_RS21325	COG1538	Outer membrane efflux protein
I6K11_RS21330	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS21335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS21340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K11_RS21345	COG1113	amino acid transport
I6K11_RS21350	COG0668	transmembrane transport
I6K11_RS21355	COG0778	Nitroreductase
I6K11_RS21360	COG2315	Protein conserved in bacteria
I6K11_RS21385	COG2977	Belongs to the P-Pant transferase superfamily
I6K11_RS21390	COG4771	TonB-dependent receptor
I6K11_RS21395	COG2382	esterase
I6K11_RS21400	COG3251	PFAM MbtH domain protein
I6K11_RS21405	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K11_RS21405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K11_RS21410	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K11_RS21415	COG1120	ATPase activity
I6K11_RS21420	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS21425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS21435	COG4592	Periplasmic binding protein
I6K11_RS21440	COG1169	isochorismate synthase
I6K11_RS21445	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K11_RS21450	COG3433	isochorismatase activity
I6K11_RS21450	COG1535	isochorismatase
I6K11_RS21455	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS21460	COG2050	protein possibly involved in aromatic compounds catabolism
I6K11_RS21465	COG1966	Carbon starvation protein
I6K11_RS21470	COG2879	small protein
I6K11_RS21475	COG0371	Dehydrogenase
I6K11_RS21480	COG0436	Aminotransferase
I6K11_RS21485	COG1475	DNA binding
I6K11_RS21490	COG3969	phosphoadenosine phosphosulfate
I6K11_RS21500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K11_RS21505	COG0450	alkyl hydroperoxide reductase
I6K11_RS21510	COG3634	alkyl hydroperoxide reductase activity
I6K11_RS21515	COG0589	response to stress
I6K11_RS21520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K11_RS21525	COG3719	Belongs to the RNase T2 family
I6K11_RS21530	COG0471	metal ion transport
I6K11_RS21545	COG3051	citrate lyase alpha subunit
I6K11_RS21550	COG2301	Belongs to the HpcH HpaI aldolase family
I6K11_RS21560	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6K11_RS21565	COG3290	protein histidine kinase activity
I6K11_RS21570	COG4565	transcriptional regulatory protein
I6K11_RS21575	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K11_RS21600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K11_RS21605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K11_RS21615	COG0583	DNA-binding transcription factor activity
I6K11_RS21630	COG1686	Belongs to the peptidase S11 family
I6K11_RS21635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K11_RS21640	COG0772	Belongs to the SEDS family
I6K11_RS21645	COG0768	penicillin binding
I6K11_RS21655	COG0799	negative regulation of ribosome biogenesis
I6K11_RS21660	COG0406	alpha-ribazole phosphatase activity
I6K11_RS21670	COG1466	dna polymerase III delta subunit
I6K11_RS21685	COG2888	peptidyl-tyrosine sulfation
I6K11_RS21695	COG1126	abc transporter atp-binding protein
I6K11_RS21700	COG0765	amino acid transport
I6K11_RS21705	COG0765	amino acid transport
I6K11_RS21710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS21715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6K11_RS21720	COG4535	Mg2 and Co2 transporter CorC
I6K11_RS21730	COG1702	phosphate starvation-inducible protein PhoH
I6K11_RS21740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K11_RS21780	COG0367	asparagine synthase
I6K11_RS21785	COG0647	UMP catabolic process
I6K11_RS21790	COG1940	carbohydrate kinase activity
I6K11_RS21790	COG1846	Transcriptional regulator
I6K11_RS21795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K11_RS21805	COG1263	PTS System
I6K11_RS21805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS21805	COG2190	(PTS) system
I6K11_RS21830	COG0735	belongs to the Fur family
I6K11_RS21840	COG0716	FMN binding
I6K11_RS21850	COG0596	Alpha beta hydrolase
I6K11_RS21855	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K11_RS21860	COG0033	Phosphoglucomutase
I6K11_RS21865	COG0531	amino acid
I6K11_RS21870	COG1982	Orn Lys Arg decarboxylase major
I6K11_RS21880	COG0745	RESPONSE REGULATOR receiver
I6K11_RS21885	COG2205	protein histidine kinase activity
I6K11_RS21915	COG3209	COG3209 Rhs family protein
I6K11_RS21925	COG3209	COG3209 Rhs family protein
I6K11_RS21935	COG3272	Protein of unknown function (DUF1722)
I6K11_RS21940	COG0415	Belongs to the DNA photolyase family
I6K11_RS21950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K11_RS21955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K11_RS21960	COG1984	allophanate hydrolase subunit 2
I6K11_RS21975	COG3180	Ammonia monooxygenase
I6K11_RS21980	COG3539	Fimbrial protein
I6K11_RS21985	COG3121	Chaperone
I6K11_RS21990	COG3188	usher protein
I6K11_RS21995	COG3539	Fimbrial protein
I6K11_RS22000	COG0372	Belongs to the citrate synthase family
I6K11_RS22010	COG2009	succinate dehydrogenase
I6K11_RS22015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K11_RS22020	COG1053	succinate dehydrogenase
I6K11_RS22025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K11_RS22030	COG0567	Dehydrogenase, E1 component
I6K11_RS22035	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K11_RS22045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K11_RS22050	COG2188	Transcriptional regulator
I6K11_RS22055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS22055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS22055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K11_RS22060	COG0383	alpha-mannosidase activity
I6K11_RS22070	COG0583	DNA-binding transcription factor activity
I6K11_RS22075	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K11_RS22080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS22080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K11_RS22085	COG1301	dicarboxylic acid transport
I6K11_RS22100	COG3799	methylaspartate ammonia-lyase activity
I6K11_RS22105	COG4865	methylaspartate mutase activity
I6K11_RS22115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K11_RS22130	COG1271	oxidase subunit
I6K11_RS22135	COG1294	oxidase, subunit
I6K11_RS22140	COG4890	Cyd operon protein YbgT
I6K11_RS22145	COG3790	cyd operon protein YbgE
I6K11_RS22150	COG0824	Thioesterase
I6K11_RS22155	COG0811	peptide transport
I6K11_RS22160	COG0848	biopolymer transport protein
I6K11_RS22165	COG3064	Membrane
I6K11_RS22175	COG2885	chlorophyll binding
I6K11_RS22180	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K11_RS22230	COG3201	nicotinamide mononucleotide transporter
I6K11_RS22235	COG1230	cation diffusion facilitator family transporter
I6K11_RS22245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K11_RS22255	COG2017	converts alpha-aldose to the beta-anomer
I6K11_RS22265	COG1085	galactose-1-phosphate uridylyltransferase
I6K11_RS22270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K11_RS22275	COG1119	ATPase activity
I6K11_RS22280	COG3585	molybdate ion transport
I6K11_RS22280	COG2005	Transcriptional regulator
I6K11_RS22290	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K11_RS22295	COG4149	molybdate abc transporter
I6K11_RS22300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K11_RS22305	COG0561	phosphatase activity
I6K11_RS22315	COG0583	DNA-binding transcription factor activity
I6K11_RS22320	COG2828	Protein conserved in bacteria
I6K11_RS22325	COG0471	metal ion transport
I6K11_RS22330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K11_RS22335	COG4677	pectinesterase activity
I6K11_RS22340	COG1881	PFAM PEBP family protein
I6K11_RS22345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K11_RS22360	COG2226	methyltransferase
I6K11_RS22365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K11_RS22375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K11_RS22385	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K11_RS22395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K11_RS22400	COG0314	molybdopterin synthase activity
I6K11_RS22405	COG0670	Belongs to the BI1 family
I6K11_RS22415	COG0670	Belongs to the BI1 family
I6K11_RS22420	COG0392	lysyltransferase activity
I6K11_RS22425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K11_RS22430	COG3568	Endonuclease Exonuclease Phosphatase
I6K11_RS22440	COG0842	Transport permease protein
I6K11_RS22445	COG0842	Transport permease protein
I6K11_RS22450	COG1131	(ABC) transporter
I6K11_RS22460	COG1309	transcriptional regulator
I6K11_RS22465	COG0513	Belongs to the DEAD box helicase family
I6K11_RS22485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K11_RS22490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K11_RS22500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K11_RS22510	COG4774	siderophore transport
I6K11_RS22525	COG0668	transmembrane transport
I6K11_RS22530	COG1126	abc transporter atp-binding protein
I6K11_RS22535	COG0765	amino acid transport
I6K11_RS22540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS22550	COG5006	permease, DMT superfamily
I6K11_RS22560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K11_RS22565	COG2194	sulfuric ester hydrolase activity
I6K11_RS22575	COG1321	iron dependent repressor
I6K11_RS22580	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K11_RS22585	COG1376	ErfK ybiS ycfS ynhG family protein
I6K11_RS22590	COG0488	(ABC) transporter
I6K11_RS22600	COG2271	Major facilitator Superfamily
I6K11_RS22615	COG0561	phosphatase activity
I6K11_RS22620	COG1882	Formate acetyltransferase
I6K11_RS22625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K11_RS22630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K11_RS22635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K11_RS22640	COG0303	'Molybdopterin
I6K11_RS22645	COG1446	asparaginase
I6K11_RS22655	COG0747	negative chemotaxis
I6K11_RS22670	COG2200	EAL domain
I6K11_RS22675	COG2199	diguanylate cyclase activity
I6K11_RS22700	COG2133	pyrroloquinoline quinone binding
I6K11_RS22705	COG0625	glutathione transferase activity
I6K11_RS22710	COG1686	Belongs to the peptidase S11 family
I6K11_RS22715	COG1349	DNA-binding transcription factor activity
I6K11_RS22720	COG0671	phosphoesterase, PA-phosphatase related
I6K11_RS22725	COG2814	Major facilitator Superfamily
I6K11_RS22735	COG0561	phosphatase activity
I6K11_RS22740	COG0738	Major facilitator superfamily
I6K11_RS22745	COG3226	Transcriptional regulator
I6K11_RS22760	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K11_RS22770	COG0778	Nitroreductase
I6K11_RS22785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K11_RS22790	COG3842	ATPase activity
I6K11_RS22795	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K11_RS22800	COG1177	transmembrane transport
I6K11_RS22810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6K11_RS22815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS22820	COG4160	amino acid transport
I6K11_RS22825	COG4215	(ABC) transporter
I6K11_RS22830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K11_RS22835	COG1126	abc transporter atp-binding protein
I6K11_RS22855	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K11_RS22860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K11_RS22865	COG0702	epimerase
I6K11_RS22870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K11_RS22875	COG0028	Belongs to the TPP enzyme family
I6K11_RS22880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K11_RS22890	COG2431	L-lysine efflux transmembrane transporter activity
I6K11_RS22895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K11_RS22900	COG3593	DNA synthesis involved in DNA repair
I6K11_RS22905	COG2990	Protein conserved in bacteria
I6K11_RS22910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS22920	COG1278	Cold shock
I6K11_RS22930	COG0542	response to heat
I6K11_RS22955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K11_RS22960	COG4988	ABC transporter
I6K11_RS22965	COG0492	ferredoxin-NADP+ reductase activity
I6K11_RS22970	COG1522	sequence-specific DNA binding
I6K11_RS22975	COG1178	ABC-type Fe3 transport system permease component
I6K11_RS22975	COG1674	ftsk spoiiie
I6K11_RS22985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K11_RS22995	COG0243	molybdopterin cofactor binding
I6K11_RS23000	COG0437	4 iron, 4 sulfur cluster binding
I6K11_RS23005	COG3302	dmso reductase anchor subunit
I6K11_RS23010	COG1335	isochorismatase
I6K11_RS23020	COG0531	amino acid
I6K11_RS23030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K11_RS23035	COG4974	Belongs to the 'phage' integrase family
I6K11_RS23105	COG4695	Portal protein
I6K11_RS23200	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS23255	COG1882	Formate acetyltransferase
I6K11_RS23260	COG2116	formate transmembrane transporter activity
I6K11_RS23275	COG0582	viral genome integration into host DNA
I6K11_RS23285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS23345	COG1846	Transcriptional regulator
I6K11_RS23435	COG1403	HNH endonuclease
I6K11_RS23440	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K11_RS23445	COG0484	heat shock protein binding
I6K11_RS23510	COG3772	lysozyme
I6K11_RS23635	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS23650	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K11_RS23665	COG2323	membrane
I6K11_RS23680	COG0501	Belongs to the peptidase M48B family
I6K11_RS23690	COG0539	negative regulation of cytoplasmic translation
I6K11_RS23700	COG0658	competence protein
I6K11_RS23700	COG2333	competence protein COMEC
I6K11_RS23705	COG1132	(ABC) transporter
I6K11_RS23715	COG3214	Protein conserved in bacteria
I6K11_RS23730	COG3173	Aminoglycoside phosphotransferase
I6K11_RS23735	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K11_RS23740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K11_RS23750	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K11_RS23760	COG2989	Protein conserved in bacteria
I6K11_RS23765	COG3108	Peptidase M15
I6K11_RS23770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K11_RS23775	COG1448	Aminotransferase
I6K11_RS23795	COG0308	aminopeptidase N
I6K11_RS23800	COG1116	anion transmembrane transporter activity
I6K11_RS23805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K11_RS23815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K11_RS23820	COG0431	NADPH-dependent FMN reductase
I6K11_RS23825	COG3539	Fimbrial protein
I6K11_RS23830	COG3121	Chaperone
I6K11_RS23835	COG3188	usher protein
I6K11_RS23840	COG3539	Fimbrial protein
I6K11_RS23845	COG3539	Fimbrial protein
I6K11_RS23850	COG3539	Fimbrial protein
I6K11_RS23855	COG3121	Chaperone
I6K11_RS23870	COG3217	Mosc domain protein beta barrel domain protein
I6K11_RS23870	COG0633	Ferredoxin
I6K11_RS23880	COG0488	(ABC) transporter
I6K11_RS23885	COG2995	paraquat-inducible protein a
I6K11_RS23890	COG3008	intermembrane lipid transfer
I6K11_RS23890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K11_RS23895	COG3009	Protein conserved in bacteria
I6K11_RS23900	COG3130	regulation of translation
I6K11_RS23910	COG1067	ATP-dependent peptidase activity
I6K11_RS23930	COG3070	regulator of competence-specific genes
I6K11_RS23935	COG1289	transmembrane transporter activity
I6K11_RS23940	COG3304	Inner membrane component domain
I6K11_RS23945	COG0210	DNA helicase
I6K11_RS23960	COG1832	CoA-binding protein
I6K11_RS23975	COG1254	Belongs to the acylphosphatase family
I6K11_RS23980	COG2920	part of a sulfur-relay system
I6K11_RS23985	COG0670	Belongs to the BI1 family
I6K11_RS23995	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K11_RS24000	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K11_RS24005	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6K11_RS24010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K11_RS24015	COG1999	signal sequence binding
I6K11_RS24020	COG1773	rubredoxin
I6K11_RS24025	COG1271	oxidase subunit
I6K11_RS24030	COG1294	oxidase, subunit
I6K11_RS24045	COG1278	Cold shock
I6K11_RS24050	COG1278	Cold shock
I6K11_RS24070	COG0348	domain, Protein
I6K11_RS24075	COG2198	Histidine kinase
I6K11_RS24075	COG0784	Response regulator, receiver
I6K11_RS24075	COG2205	protein histidine kinase activity
I6K11_RS24080	COG1879	ABC-type sugar transport system periplasmic component
I6K11_RS24085	COG0745	RESPONSE REGULATOR receiver
I6K11_RS24090	COG3005	denitrification pathway
I6K11_RS24095	COG0243	molybdopterin cofactor binding
I6K11_RS24100	COG3381	protein complex oligomerization
I6K11_RS24140	COG3729	General stress protein
I6K11_RS24145	COG2233	PERMEase
I6K11_RS24180	COG1309	transcriptional regulator
I6K11_RS24185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K11_RS24185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K11_RS24185	COG0506	proline dehydrogenase activity
I6K11_RS24195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K11_RS24205	COG2822	iron ion transport
I6K11_RS24215	COG1702	phosphate starvation-inducible protein PhoH
I6K11_RS24220	COG3658	cytochrome
I6K11_RS24225	COG1215	transferase activity, transferring glycosyl groups
I6K11_RS24230	COG0726	polysaccharide deacetylase
I6K11_RS24230	COG1649	PFAM Uncharacterised BCR, COG1649
I6K11_RS24235	COG0457	Tetratricopeptide repeat
I6K11_RS24240	COG3706	GGDEF domain
I6K11_RS24260	COG3381	protein complex oligomerization
I6K11_RS24270	COG1462	curli production assembly transport component CsgG
I6K11_RS24285	COG2197	response regulator
I6K11_RS24310	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K11_RS24315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K11_RS24330	COG2943	transferase activity, transferring hexosyl groups
I6K11_RS24335	COG5645	(Lipo)protein
I6K11_RS24350	COG1560	Kdo2-lipid A biosynthetic process
I6K11_RS24365	COG3038	cytochrome b561
I6K11_RS24400	COG2999	glutathione oxidoreductase activity
I6K11_RS24410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K11_RS24420	COG0673	inositol 2-dehydrogenase activity
I6K11_RS24425	COG0728	peptidoglycan biosynthetic process
I6K11_RS24430	COG3418	PFAM FlgN family protein
I6K11_RS24435	COG2747	anti-sigma28 factor FlgM
I6K11_RS24440	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6K11_RS24445	COG1815	bacterial-type flagellum-dependent cell motility
I6K11_RS24450	COG1558	bacterial-type flagellum-dependent cell motility
I6K11_RS24455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6K11_RS24460	COG1749	Flagellar hook protein flgE
I6K11_RS24465	COG4787	bacterial-type flagellum-dependent cell motility
I6K11_RS24470	COG4786	Flagellar basal body rod
I6K11_RS24485	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6K11_RS24485	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K11_RS24490	COG1256	bacterial-type flagellum assembly
I6K11_RS24495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K11_RS24510	COG1530	ribonuclease E activity
I6K11_RS24515	COG0564	pseudouridine synthase activity
I6K11_RS24520	COG0424	maF-like protein
I6K11_RS24525	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K11_RS24545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K11_RS24550	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS24560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K11_RS24570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K11_RS24575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K11_RS24585	COG0470	DNA polymerase III
I6K11_RS24590	COG0084	hydrolase, TatD family'
I6K11_RS24595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K11_RS24595	COG1263	PTS System
I6K11_RS24600	COG4773	Receptor
I6K11_RS24605	COG0537	adenosine 5'-monophosphoramidase activity
I6K11_RS24610	COG5633	Lipoprotein
I6K11_RS24615	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6K11_RS24635	COG1252	NADH dehydrogenase
I6K11_RS24640	COG3134	Outer membrane lipoprotein
I6K11_RS24645	COG1309	transcriptional regulator
I6K11_RS24660	COG1388	LysM domain
I6K11_RS24660	COG1376	ErfK ybiS ycfS ynhG family protein
I6K11_RS24665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K11_RS24670	COG4763	Acyl-transferase
I6K11_RS24675	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K11_RS24685	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K11_RS24695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K11_RS24700	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K11_RS24710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K11_RS24715	COG1177	transmembrane transport
I6K11_RS24720	COG0582	viral genome integration into host DNA
I6K11_RS24730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K11_RS24745	COG3646	Phage regulatory protein
I6K11_RS24760	COG1396	sequence-specific DNA binding
I6K11_RS24785	COG1846	Transcriptional regulator
I6K11_RS24840	COG1403	HNH endonuclease
I6K11_RS24845	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K11_RS24890	COG3772	lysozyme
I6K11_RS24920	COG4220	transposase activity
I6K11_RS25025	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS25030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K11_RS25035	COG0500	methyltransferase
I6K11_RS25050	COG3842	ATPase activity
I6K11_RS25060	COG2850	peptidyl-arginine hydroxylation
I6K11_RS25065	COG2205	protein histidine kinase activity
I6K11_RS25075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K11_RS25095	COG1187	pseudouridine synthase activity
I6K11_RS25110	COG0538	isocitrate dehydrogenase activity
I6K11_RS25130	COG5562	phage envelope protein
I6K11_RS25135	COG0789	Transcriptional regulator
I6K11_RS25140	COG2200	EAL domain
I6K11_RS25170	COG2200	EAL domain
I6K11_RS25210	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS25220	COG2894	cell division
I6K11_RS25250	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K11_RS25265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K11_RS25270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K11_RS25275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6K11_RS25290	COG2719	SpoVR family
I6K11_RS25300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K11_RS25315	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K11_RS25325	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K11_RS25340	COG0157	Belongs to the NadC ModD family
I6K11_RS25345	COG0500	methyltransferase
I6K11_RS25350	COG1120	ATPase activity
I6K11_RS25355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K11_RS25360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K11_RS25370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K11_RS25370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K11_RS25370	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K11_RS25375	COG1461	Dihydroxyacetone kinase
I6K11_RS25380	COG2376	Dihydroxyacetone kinase
I6K11_RS25385	COG3284	Transcriptional regulator
I6K11_RS25390	COG3468	outer membrane autotransporter barrel domain protein
I6K11_RS25395	COG0012	GTP binding
I6K11_RS25410	COG0659	secondary active sulfate transmembrane transporter activity
I6K11_RS25415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K11_RS25440	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K11_RS25445	COG3094	Invasion gene expression up-regulator, SirB
I6K11_RS25450	COG2912	Transglutaminase-like superfamily
I6K11_RS25475	COG0387	Pfam Sodium calcium exchanger
I6K11_RS25480	COG4572	Cation transport regulator
I6K11_RS25485	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K11_RS25490	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K11_RS25495	COG4932	domain protein
I6K11_RS25500	COG2197	response regulator
I6K11_RS25505	COG3850	Histidine kinase
I6K11_RS25510	COG2223	nitrite transmembrane transporter activity
I6K11_RS25515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K11_RS25520	COG1140	nitrate reductase beta subunit
I6K11_RS25525	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K11_RS25530	COG2181	nitrate reductase activity
I6K11_RS25570	COG0788	formyltetrahydrofolate deformylase activity
I6K11_RS25580	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K11_RS25585	COG0745	RESPONSE REGULATOR receiver
I6K11_RS25590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K11_RS25600	COG1435	thymidine kinase activity
I6K11_RS25605	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS25605	COG1454	alcohol dehydrogenase
I6K11_RS25610	COG2095	MarC family integral membrane protein
I6K11_RS25620	COG4166	transmembrane transport
I6K11_RS25625	COG0601	transmembrane transport
I6K11_RS25630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K11_RS25635	COG0444	Belongs to the ABC transporter superfamily
I6K11_RS25640	COG4608	Belongs to the ABC transporter superfamily
I6K11_RS25660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K11_RS25665	COG2350	Protein conserved in bacteria
I6K11_RS25675	COG1607	acyl-coa hydrolase
I6K11_RS25695	COG3047	cAMP biosynthetic process
I6K11_RS25700	COG3685	Protein conserved in bacteria
I6K11_RS25705	COG3685	Protein conserved in bacteria
I6K11_RS25710	COG3729	General stress protein
I6K11_RS25715	COG0159	tryptophan synthase activity
I6K11_RS25725	COG0134	indole-3-glycerol-phosphate synthase activity
I6K11_RS25725	COG0135	phosphoribosylanthranilate isomerase activity
I6K11_RS25730	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K11_RS25730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K11_RS25735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K11_RS25745	COG0613	PHP domain protein
I6K11_RS25750	COG0009	L-threonylcarbamoyladenylate synthase
I6K11_RS25755	COG4907	membrane protein (DUF2207)
I6K11_RS25760	COG1187	pseudouridine synthase activity
I6K11_RS25775	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K11_RS25780	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS25785	COG0616	signal peptide processing
I6K11_RS25800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K11_RS25805	COG0583	DNA-binding transcription factor activity
I6K11_RS25830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K11_RS25840	COG0671	phosphoesterase, PA-phosphatase related
I6K11_RS25845	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K11_RS25850	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K11_RS25860	COG0023	Translation Initiation Factor
I6K11_RS25870	COG1349	DNA-binding transcription factor activity
I6K11_RS25880	COG5001	Diguanylate cyclase
I6K11_RS25895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K11_RS25895	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K11_RS25900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K11_RS25910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K11_RS25915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K11_RS25925	COG2814	Major facilitator Superfamily
I6K11_RS25930	COG4172	Belongs to the ABC transporter superfamily
I6K11_RS25935	COG4172	Belongs to the ABC transporter superfamily
I6K11_RS25940	COG4171	peptide transport system, permease
I6K11_RS25945	COG4168	peptide transport system, permease
I6K11_RS25950	COG4166	transmembrane transport
I6K11_RS25960	COG0531	amino acid
I6K11_RS25970	COG0174	glutamine synthetase
I6K11_RS25975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K11_RS25980	COG1917	Cupin 2, conserved barrel domain protein
I6K11_RS25980	COG1396	sequence-specific DNA binding
I6K11_RS25985	COG1012	belongs to the aldehyde dehydrogenase family
I6K11_RS25990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K11_RS25995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K11_RS26005	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K11_RS26010	COG1842	Phage shock protein A
I6K11_RS26020	COG1983	PspC domain protein
I6K11_RS26030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K11_RS26035	COG0366	Alpha amylase catalytic
I6K11_RS26040	COG1653	transport
I6K11_RS26045	COG1175	transmembrane transport
I6K11_RS26050	COG0395	ABC-type sugar transport system, permease component
I6K11_RS26055	COG1063	alcohol dehydrogenase
I6K11_RS26060	COG1082	Xylose isomerase domain protein TIM barrel
I6K11_RS26065	COG0673	inositol 2-dehydrogenase activity
I6K11_RS26080	COG4932	domain protein
I6K11_RS26080	COG5492	domain, Protein
I6K11_RS26125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K11_RS26130	COG1475	DNA binding
I6K11_RS26135	COG1475	DNA binding
I6K11_RS26235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K11_RS26265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6K11_RS26320	COG0328	RNA-DNA hybrid ribonuclease activity
I6K11_RS26350	COG0237	dephospho-CoA kinase activity
I6K11_RS26365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6K11_RS26375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K11_RS26380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K11_RS26510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K11_RS26640	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS26670	COG3941	tape measure
I6K11_RS26825	COG1476	TRANSCRIPTIONal
I6K11_RS26840	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6K11_RS26875	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS26875	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K11_RS26960	COG0740	serine-type endopeptidase activity
I6K11_RS26985	COG1475	DNA binding
I6K11_RS26995	COG1475	DNA binding
I6K11_RS27000	COG1475	DNA binding
I6K11_RS27100	COG3436	PFAM IS66 Orf2 family protein
I6K11_RS27125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K11_RS27135	COG1902	pentaerythritol trinitrate reductase activity
I6K11_RS27140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K11_RS27145	COG1028	Short-chain dehydrogenase reductase Sdr
I6K11_RS27150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K11_RS27195	COG0577	efflux transmembrane transporter activity
I6K11_RS27195	COG1136	(ABC) transporter
I6K11_RS27200	COG1136	(ABC) transporter
I6K11_RS27200	COG0577	efflux transmembrane transporter activity
I6K11_RS27205	COG0577	efflux transmembrane transporter activity
I6K11_RS27205	COG1136	(ABC) transporter
I6K11_RS27220	COG0672	)-iron permease
I6K11_RS27225	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K11_RS27230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins