locus-tag	class	description
I6K12_RS00300	COG1475	DNA binding
I6K12_RS00495	COG4771	TonB-dependent receptor
I6K12_RS00525	COG3436	PFAM IS66 Orf2 family protein
I6K12_RS00540	COG3344	reverse transcriptase
I6K12_RS00615	COG1695	Transcriptional regulator
I6K12_RS00640	COG3173	Aminoglycoside phosphotransferase
I6K12_RS00685	COG0697	spore germination
I6K12_RS00705	COG0753	catalase activity
I6K12_RS00710	COG3394	polysaccharide catabolic process
I6K12_RS00715	COG1486	melibiose metabolic process
I6K12_RS00720	COG1917	Cupin 2, conserved barrel domain protein
I6K12_RS00720	COG2169	Transcriptional regulator
I6K12_RS00725	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K12_RS00730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K12_RS00735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K12_RS00740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K12_RS00750	COG0322	excinuclease ABC activity
I6K12_RS00760	COG3678	ATP-independent chaperone mediated protein folding
I6K12_RS00790	COG0708	Exodeoxyribonuclease III
I6K12_RS00795	COG0398	Pfam SNARE associated Golgi protein
I6K12_RS00805	COG0398	Pfam SNARE associated Golgi protein
I6K12_RS00810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K12_RS00815	COG4134	Bacterial extracellular solute-binding protein
I6K12_RS00820	COG4135	transport system, permease component
I6K12_RS00825	COG4136	ATPase activity
I6K12_RS00830	COG2897	thiosulfate sulfurtransferase activity
I6K12_RS00835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K12_RS00840	COG0494	nUDIX hydrolase
I6K12_RS00850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K12_RS00855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K12_RS00865	COG0778	Nitroreductase
I6K12_RS00870	COG0616	signal peptide processing
I6K12_RS00875	COG0252	asparaginase activity
I6K12_RS00880	COG1335	isochorismatase
I6K12_RS00885	COG2814	Major facilitator Superfamily
I6K12_RS00890	COG1349	DNA-binding transcription factor activity
I6K12_RS00895	COG0667	Aldo Keto reductase
I6K12_RS00900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS00905	COG0191	fructose-bisphosphate aldolase activity
I6K12_RS00910	COG1063	alcohol dehydrogenase
I6K12_RS00915	COG2271	Major facilitator Superfamily
I6K12_RS00920	COG1063	alcohol dehydrogenase
I6K12_RS00925	COG3139	Protein of unknown function (DUF1315)
I6K12_RS00935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K12_RS00940	COG0676	glucose-6-phosphate 1-epimerase activity
I6K12_RS00945	COG0656	L-ascorbic acid biosynthetic process
I6K12_RS00950	COG3713	MltA-interacting MipA family protein
I6K12_RS00955	COG2766	serine protein kinase
I6K12_RS00965	COG2199	diguanylate cyclase activity
I6K12_RS00970	COG2199	diguanylate cyclase activity
I6K12_RS00975	COG3189	MarR family transcriptional regulator
I6K12_RS00980	COG3042	response to heat
I6K12_RS00985	COG2203	Gaf domain
I6K12_RS00985	COG2199	diguanylate cyclase activity
I6K12_RS01000	COG2261	transglycosylase associated protein
I6K12_RS01010	COG3615	Tellurite resistance protein tehB
I6K12_RS01020	COG0583	DNA-binding transcription factor activity
I6K12_RS01025	COG0473	3-isopropylmalate dehydrogenase activity
I6K12_RS01030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K12_RS01035	COG4638	Rieske (2fe-2S)
I6K12_RS01045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K12_RS01050	COG0318	PFAM AMP-dependent synthetase and ligase
I6K12_RS01055	COG3065	identical protein binding
I6K12_RS01060	COG1214	PFAM Peptidase M22, glycoprotease
I6K12_RS01065	COG1199	ATP-dependent helicase activity
I6K12_RS01070	COG0251	oxidation-reduction process
I6K12_RS01085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K12_RS01095	COG1760	l-serine dehydratase
I6K12_RS01100	COG2200	EAL domain
I6K12_RS01105	COG1253	flavin adenine dinucleotide binding
I6K12_RS01110	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS01110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS01115	COG3715	PTS system
I6K12_RS01120	COG3716	PTS system mannose fructose sorbose family IID component
I6K12_RS01135	COG2226	methyltransferase
I6K12_RS01165	COG1414	Transcriptional regulator
I6K12_RS01170	COG2814	Major facilitator Superfamily
I6K12_RS01180	COG0793	Belongs to the peptidase S41A family
I6K12_RS01190	COG1956	GAF domain-containing protein
I6K12_RS01195	COG2995	paraquat-inducible protein a
I6K12_RS01200	COG3008	intermembrane lipid transfer
I6K12_RS01220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K12_RS01230	COG1276	copper resistance
I6K12_RS01235	COG2372	response to copper ion
I6K12_RS01245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K12_RS01250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS01255	COG1770	oligopeptidase
I6K12_RS01260	COG2979	Protein of unknown function (DUF533)
I6K12_RS01270	COG3141	response to X-ray
I6K12_RS01280	COG0800	Aldolase
I6K12_RS01285	COG0129	dihydroxy-acid dehydratase activity
I6K12_RS01290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K12_RS01295	COG1737	Transcriptional regulator
I6K12_RS01300	COG0469	pyruvate kinase activity
I6K12_RS01305	COG1560	Kdo2-lipid A biosynthetic process
I6K12_RS01310	COG0739	heme binding
I6K12_RS01315	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K12_RS01325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K12_RS01355	COG0217	transcriptional regulatory protein
I6K12_RS01360	COG0494	nUDIX hydrolase
I6K12_RS01370	COG1335	isochorismatase
I6K12_RS01375	COG1801	Protein of unknown function DUF72
I6K12_RS01380	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K12_RS01395	COG0243	molybdopterin cofactor binding
I6K12_RS01400	COG3005	denitrification pathway
I6K12_RS01410	COG3102	Protein conserved in bacteria
I6K12_RS01425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K12_RS01430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K12_RS01435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K12_RS01440	COG0745	RESPONSE REGULATOR receiver
I6K12_RS01450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6K12_RS01455	COG0840	transmembrane signaling receptor activity
I6K12_RS01460	COG0840	transmembrane signaling receptor activity
I6K12_RS01465	COG0835	chemotaxis
I6K12_RS01470	COG0643	Histidine kinase
I6K12_RS01470	COG2198	Histidine kinase
I6K12_RS01475	COG1360	Flagellar Motor Protein
I6K12_RS01480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K12_RS01495	COG0589	response to stress
I6K12_RS01505	COG1877	trehalose-phosphatase activity
I6K12_RS01510	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS01515	COG1129	ABC transporter
I6K12_RS01520	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS01525	COG1528	Iron-storage protein
I6K12_RS01545	COG1528	Iron-storage protein
I6K12_RS01555	COG0814	amino acid
I6K12_RS01560	COG3012	SEC-C Motif Domain Protein
I6K12_RS01560	COG3318	Belongs to the UPF0149 family
I6K12_RS01565	COG4974	Belongs to the 'phage' integrase family
I6K12_RS01645	COG4695	Portal protein
I6K12_RS01725	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K12_RS01725	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K12_RS01730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K12_RS01820	COG2197	response regulator
I6K12_RS01835	COG2197	response regulator
I6K12_RS01840	COG1126	abc transporter atp-binding protein
I6K12_RS01845	COG0765	amino acid transport
I6K12_RS01855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS01865	COG1191	sigma factor activity
I6K12_RS01875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K12_RS01880	COG1516	flagellar protein fliS
I6K12_RS01890	COG0366	Alpha amylase catalytic
I6K12_RS01900	COG2391	methyltransferase activity
I6K12_RS01905	COG0425	Belongs to the sulfur carrier protein TusA family
I6K12_RS01910	COG2135	peptidase activity
I6K12_RS01925	COG2207	Transcriptional regulator
I6K12_RS01930	COG1881	PFAM PEBP family protein
I6K12_RS01935	COG2076	Multidrug Resistance protein
I6K12_RS01945	COG1766	The M ring may be actively involved in energy transduction
I6K12_RS01950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K12_RS01955	COG1317	bacterial-type flagellum organization
I6K12_RS01960	COG1157	protein secretion by the type III secretion system
I6K12_RS01965	COG2882	bacterial-type flagellum organization
I6K12_RS01970	COG3144	bacterial-type flagellum assembly
I6K12_RS01975	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K12_RS01980	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K12_RS01985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K12_RS01990	COG3190	flagellar
I6K12_RS01995	COG1338	Plays a role in the flagellum-specific transport system
I6K12_RS02000	COG1987	bacterial-type flagellum assembly
I6K12_RS02005	COG1684	flagellar biosynthetic protein fliR
I6K12_RS02010	COG2197	response regulator
I6K12_RS02035	COG5475	Uncharacterized small protein (DUF2158)
I6K12_RS02040	COG2354	Protein conserved in bacteria
I6K12_RS02045	COG0697	spore germination
I6K12_RS02050	COG3727	T/G mismatch-specific endonuclease activity
I6K12_RS02055	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K12_RS02075	COG2205	protein histidine kinase activity
I6K12_RS02080	COG0745	RESPONSE REGULATOR receiver
I6K12_RS02085	COG2351	hydroxyisourate hydrolase activity
I6K12_RS02100	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K12_RS02125	COG1169	isochorismate synthase
I6K12_RS02130	COG2814	Major facilitator Superfamily
I6K12_RS02135	COG1132	(ABC) transporter
I6K12_RS02150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K12_RS02150	COG3433	isochorismatase activity
I6K12_RS02150	COG2226	methyltransferase
I6K12_RS02170	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K12_RS02175	COG4771	TonB-dependent receptor
I6K12_RS02180	COG4932	domain protein
I6K12_RS02180	COG1388	LysM domain
I6K12_RS02180	COG2373	Large extracellular alpha-helical protein
I6K12_RS02195	COG0477	Major facilitator Superfamily
I6K12_RS02200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K12_RS02205	COG0217	transcriptional regulatory protein
I6K12_RS02215	COG0534	Mate efflux family protein
I6K12_RS02225	COG0583	DNA-binding transcription factor activity
I6K12_RS02230	COG0583	DNA-binding transcription factor activity
I6K12_RS02240	COG1376	ErfK ybiS ycfS ynhG family protein
I6K12_RS02255	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6K12_RS02290	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K12_RS02395	COG2003	Belongs to the UPF0758 family
I6K12_RS02440	COG1289	transmembrane transporter activity
I6K12_RS02450	COG1686	Belongs to the peptidase S11 family
I6K12_RS02455	COG2925	Exonuclease
I6K12_RS02460	COG0425	Belongs to the sulfur carrier protein TusA family
I6K12_RS02465	COG2391	methyltransferase activity
I6K12_RS02470	COG0531	amino acid
I6K12_RS02480	COG0583	DNA-binding transcription factor activity
I6K12_RS02485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K12_RS02490	COG4115	mRNA cleavage
I6K12_RS02495	COG2161	toxin-antitoxin pair type II binding
I6K12_RS02520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K12_RS02520	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K12_RS02525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K12_RS02550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6K12_RS02555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K12_RS02575	COG1216	Glycosyl transferase, family 2
I6K12_RS02585	COG4641	Protein conserved in bacteria
I6K12_RS02585	COG0438	transferase activity, transferring glycosyl groups
I6K12_RS02600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K12_RS02610	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K12_RS02615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K12_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K12_RS02630	COG0438	transferase activity, transferring glycosyl groups
I6K12_RS02635	COG2327	Polysaccharide pyruvyl transferase
I6K12_RS02640	COG2244	polysaccharide biosynthetic process
I6K12_RS02645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K12_RS02650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K12_RS02655	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6K12_RS02655	COG0662	Cupin 2, conserved barrel domain protein
I6K12_RS02660	COG0297	glycogen (starch) synthase activity
I6K12_RS02665	COG1051	belongs to the nudix hydrolase family
I6K12_RS02670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K12_RS02675	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6K12_RS02680	COG0110	maltose O-acetyltransferase activity
I6K12_RS02685	COG1216	Glycosyl transferase, family 2
I6K12_RS02695	COG0438	transferase activity, transferring glycosyl groups
I6K12_RS02700	COG1045	serine acetyltransferase
I6K12_RS02705	COG0463	Glycosyl transferase, family 2
I6K12_RS02710	COG3206	protein involved in exopolysaccharide biosynthesis
I6K12_RS02710	COG0489	protein tyrosine kinase activity
I6K12_RS02715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K12_RS02720	COG1596	polysaccharide export
I6K12_RS02725	COG1253	flavin adenine dinucleotide binding
I6K12_RS02730	COG2982	Protein involved in outer membrane biogenesis
I6K12_RS02740	COG0572	uridine kinase
I6K12_RS02745	COG5002	protein histidine kinase activity
I6K12_RS02745	COG3447	MASE1 domain protein
I6K12_RS02745	COG5001	Diguanylate cyclase
I6K12_RS02750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K12_RS02755	COG0443	Heat shock 70 kDa protein
I6K12_RS02760	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6K12_RS02765	COG3779	Protein conserved in bacteria
I6K12_RS02770	COG0631	protein serine/threonine phosphatase activity
I6K12_RS02775	COG4245	von Willebrand factor, type A
I6K12_RS02815	COG2205	protein histidine kinase activity
I6K12_RS02820	COG0745	RESPONSE REGULATOR receiver
I6K12_RS02830	COG0826	peptidase U32
I6K12_RS02850	COG1063	alcohol dehydrogenase
I6K12_RS02855	COG3775	system Galactitol-specific IIC component
I6K12_RS02860	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K12_RS02865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS02880	COG1830	Aldolase
I6K12_RS02885	COG2211	Major facilitator Superfamily
I6K12_RS02890	COG1397	ADP-ribosylglycohydrolase
I6K12_RS02895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS02900	COG2188	Transcriptional regulator
I6K12_RS02905	COG3757	hydrolase, family 25
I6K12_RS02910	COG0351	phosphomethylpyrimidine kinase
I6K12_RS02930	COG5455	response to cobalt ion
I6K12_RS02935	COG3539	Fimbrial protein
I6K12_RS02940	COG3188	usher protein
I6K12_RS02945	COG3121	Chaperone
I6K12_RS02955	COG3539	Fimbrial protein
I6K12_RS02965	COG0489	protein tyrosine kinase activity
I6K12_RS02975	COG3831	ATPase activity
I6K12_RS02980	COG3831	ATPase activity
I6K12_RS02990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K12_RS02995	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K12_RS03000	COG4715	Zinc finger, swim domain protein
I6K12_RS03005	COG4808	Protein conserved in bacteria
I6K12_RS03010	COG4807	Protein conserved in bacteria
I6K12_RS03015	COG3279	Response regulator of the LytR AlgR family
I6K12_RS03020	COG3275	phosphorelay sensor kinase activity
I6K12_RS03025	COG0789	Transcriptional regulator
I6K12_RS03035	COG1174	glycine betaine transport
I6K12_RS03040	COG1125	glycine betaine transport
I6K12_RS03045	COG1174	glycine betaine transport
I6K12_RS03050	COG1732	Glycine betaine
I6K12_RS03055	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K12_RS03060	COG0277	FAD linked oxidase domain protein
I6K12_RS03065	COG1686	Belongs to the peptidase S11 family
I6K12_RS03075	COG0586	Pfam SNARE associated Golgi protein
I6K12_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS03085	COG1538	Outer membrane efflux protein
I6K12_RS03095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K12_RS03105	COG1346	cytolysis
I6K12_RS03115	COG2949	membrane
I6K12_RS03125	COG0493	'glutamate synthase
I6K12_RS03130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K12_RS03130	COG0167	dihydroorotate dehydrogenase activity
I6K12_RS03135	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS03140	COG1129	ABC transporter
I6K12_RS03145	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS03150	COG1609	Transcriptional regulator
I6K12_RS03155	COG2311	Membrane
I6K12_RS03175	COG0833	amino acid
I6K12_RS03180	COG0583	DNA-binding transcription factor activity
I6K12_RS03185	COG2855	membrane
I6K12_RS03195	COG1522	sequence-specific DNA binding
I6K12_RS03195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS03200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K12_RS03210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K12_RS03215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K12_RS03220	COG2313	pseudouridylate synthase activity
I6K12_RS03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS03230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K12_RS03230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS03230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS03235	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K12_RS03240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS03240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS03245	COG2814	Major facilitator Superfamily
I6K12_RS03260	COG0246	Mannitol dehydrogenase
I6K12_RS03265	COG0523	cobalamin synthesis protein
I6K12_RS03270	COG0671	phosphoesterase, PA-phosphatase related
I6K12_RS03275	COG0791	NLP P60 protein
I6K12_RS03280	COG2200	EAL domain
I6K12_RS03285	COG4166	transmembrane transport
I6K12_RS03290	COG4174	ABC transporter (Permease)
I6K12_RS03295	COG4239	(ABC) transporter, permease
I6K12_RS03300	COG4172	Belongs to the ABC transporter superfamily
I6K12_RS03310	COG2814	Major facilitator Superfamily
I6K12_RS03315	COG1187	pseudouridine synthase activity
I6K12_RS03320	COG1061	Type III restriction enzyme res subunit
I6K12_RS03340	COG3083	sulfuric ester hydrolase activity
I6K12_RS03350	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS03355	COG2197	response regulator
I6K12_RS03360	COG4235	cytochrome complex assembly
I6K12_RS03360	COG3088	subunit of a heme lyase
I6K12_RS03365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K12_RS03370	COG1138	Cytochrome C-type biogenesis protein
I6K12_RS03380	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K12_RS03385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K12_RS03390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K12_RS03395	COG4133	protoheme IX ABC transporter activity
I6K12_RS03400	COG3005	denitrification pathway
I6K12_RS03405	COG3043	anaerobic respiration
I6K12_RS03410	COG0348	domain, Protein
I6K12_RS03415	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS03425	COG3062	negative regulation of establishment of protein localization
I6K12_RS03430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS03430	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS03445	COG4615	Cyclic peptide transporter
I6K12_RS03450	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K12_RS03455	COG2169	Transcriptional regulator
I6K12_RS03455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K12_RS03460	COG1477	protein flavinylation
I6K12_RS03465	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K12_RS03470	COG0642	Histidine kinase
I6K12_RS03470	COG2198	Histidine kinase
I6K12_RS03475	COG2197	response regulator
I6K12_RS03480	COG0784	Response regulator, receiver
I6K12_RS03480	COG2205	protein histidine kinase activity
I6K12_RS03485	COG3852	Histidine kinase
I6K12_RS03490	COG2204	response regulator
I6K12_RS03495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K12_RS03500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K12_RS03505	COG2031	fatty acid transporter
I6K12_RS03510	COG0183	Belongs to the thiolase family
I6K12_RS03515	COG4676	Protein conserved in bacteria
I6K12_RS03520	COG5445	Predicted secreted protein (DUF2300)
I6K12_RS03525	COG2373	Large extracellular alpha-helical protein
I6K12_RS03530	COG3234	Protein of unknown function (DUF1175)
I6K12_RS03535	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6K12_RS03540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K12_RS03550	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS03555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K12_RS03560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K12_RS03565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K12_RS03570	COG3642	lipopolysaccharide core region biosynthetic process
I6K12_RS03575	COG2814	Major facilitator Superfamily
I6K12_RS03580	COG0583	DNA-binding transcription factor activity
I6K12_RS03585	COG0584	glycerophosphoryl diester phosphodiesterase
I6K12_RS03590	COG2271	Major facilitator Superfamily
I6K12_RS03595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K12_RS03605	COG0247	lactate metabolic process
I6K12_RS03610	COG5464	transposase or invertase
I6K12_RS03625	COG2271	Major facilitator Superfamily
I6K12_RS03635	COG1414	Transcriptional regulator
I6K12_RS03700	COG0318	PFAM AMP-dependent synthetase and ligase
I6K12_RS03710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K12_RS03725	COG1169	isochorismate synthase
I6K12_RS03730	COG4575	ribosome binding
I6K12_RS03735	COG2153	protein acetylation
I6K12_RS03750	COG2234	aminopeptidase activity
I6K12_RS03765	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K12_RS03770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K12_RS03780	COG0839	Belongs to the complex I subunit 6 family
I6K12_RS03795	COG1034	ATP synthesis coupled electron transport
I6K12_RS03800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K12_RS03805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K12_RS03825	COG0583	DNA-binding transcription factor activity
I6K12_RS03830	COG0436	Aminotransferase
I6K12_RS03840	COG0490	domain, Protein
I6K12_RS03840	COG0471	metal ion transport
I6K12_RS03845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K12_RS03860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K12_RS03865	COG0280	phosphate acetyltransferase
I6K12_RS03865	COG0857	belongs to the CobB CobQ family
I6K12_RS03870	COG1288	antiporter activity
I6K12_RS03875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K12_RS03880	COG0622	Phosphoesterase
I6K12_RS03885	COG0625	glutathione transferase activity
I6K12_RS03890	COG0625	glutathione transferase activity
I6K12_RS03895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K12_RS03900	COG1090	epimerase
I6K12_RS03905	COG5464	transposase or invertase
I6K12_RS03910	COG4598	ABC transporter
I6K12_RS03915	COG4160	amino acid transport
I6K12_RS03920	COG4215	(ABC) transporter
I6K12_RS03925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS03930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS03935	COG0163	prenyltransferase activity
I6K12_RS03940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K12_RS03945	COG1286	toxin biosynthetic process
I6K12_RS03950	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K12_RS03955	COG0285	dihydrofolate synthase activity
I6K12_RS03965	COG0586	Pfam SNARE associated Golgi protein
I6K12_RS03975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K12_RS03990	COG2814	Major facilitator Superfamily
I6K12_RS03995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K12_RS04010	COG3101	peptidyl-lysine hydroxylation
I6K12_RS04015	COG0730	response to heat
I6K12_RS04030	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K12_RS04045	COG3539	Fimbrial protein
I6K12_RS04050	COG3539	Fimbrial protein
I6K12_RS04055	COG3539	Fimbrial protein
I6K12_RS04060	COG3121	Chaperone
I6K12_RS04065	COG3188	usher protein
I6K12_RS04070	COG3539	Fimbrial protein
I6K12_RS04075	COG2062	phosphohistidine phosphatase, SixA
I6K12_RS04090	COG3691	Protein conserved in bacteria
I6K12_RS04095	COG2067	long-chain fatty acid transport protein
I6K12_RS04105	COG2853	Lipoprotein
I6K12_RS04110	COG2116	formate transmembrane transporter activity
I6K12_RS04120	COG0582	viral genome integration into host DNA
I6K12_RS04210	COG0477	Major facilitator Superfamily
I6K12_RS04215	COG1566	PFAM secretion protein HlyD family protein
I6K12_RS04220	COG2197	response regulator
I6K12_RS04225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS04225	COG0784	Response regulator, receiver
I6K12_RS04225	COG2205	protein histidine kinase activity
I6K12_RS04225	COG2198	Histidine kinase
I6K12_RS04230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K12_RS04235	COG0679	Auxin Efflux Carrier
I6K12_RS04240	COG0028	Belongs to the TPP enzyme family
I6K12_RS04265	COG1560	Kdo2-lipid A biosynthetic process
I6K12_RS04275	COG0436	Aminotransferase
I6K12_RS04280	COG3275	phosphorelay sensor kinase activity
I6K12_RS04285	COG3279	Response regulator of the LytR AlgR family
I6K12_RS04290	COG2207	Transcriptional regulator
I6K12_RS04295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS04295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS04295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K12_RS04300	COG1363	Peptidase, m42
I6K12_RS04305	COG0006	proline dipeptidase activity
I6K12_RS04310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS04315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS04340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K12_RS04345	COG2199	diguanylate cyclase activity
I6K12_RS04345	COG2200	EAL domain
I6K12_RS04360	COG3415	Transposase
I6K12_RS04365	COG3415	Transposase
I6K12_RS04400	COG0583	DNA-binding transcription factor activity
I6K12_RS04410	COG2211	Major facilitator Superfamily
I6K12_RS04415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K12_RS04425	COG0583	DNA-binding transcription factor activity
I6K12_RS04430	COG0385	Bile acid
I6K12_RS04435	COG3530	Putative quorum-sensing-regulated virulence factor
I6K12_RS04455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K12_RS04460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS04465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K12_RS04470	COG2190	(PTS) system
I6K12_RS04485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K12_RS04490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K12_RS04495	COG4208	sulfate ABC transporter
I6K12_RS04500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K12_RS04505	COG4150	thiosulfate binding
I6K12_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS04525	COG1263	PTS System
I6K12_RS04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS04530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K12_RS04540	COG2837	iron assimilation
I6K12_RS04560	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K12_RS04570	COG2207	Transcriptional regulator
I6K12_RS04575	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K12_RS04580	COG4816	utilization protein
I6K12_RS04590	COG4303	Ethanolamine ammonia lyase large subunit
I6K12_RS04595	COG4819	ethanolamine utilization protein
I6K12_RS04600	COG3192	ethanolamine utilization protein
I6K12_RS04605	COG1454	alcohol dehydrogenase
I6K12_RS04610	COG4820	ethanolamine utilization protein (EutJ)
I6K12_RS04615	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS04620	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K12_RS04625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K12_RS04630	COG0280	phosphate acetyltransferase
I6K12_RS04635	COG4812	Cobalamin adenosyltransferase
I6K12_RS04640	COG4766	ethanolamine catabolic process
I6K12_RS04645	COG4917	ethanolamine utilization protein
I6K12_RS04650	COG4810	utilization protein
I6K12_RS04655	COG0280	phosphate acetyltransferase
I6K12_RS04655	COG0281	malic enzyme
I6K12_RS04660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K12_RS04665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K12_RS04670	COG5342	invasion associated locus B
I6K12_RS04680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS04680	COG0493	'glutamate synthase
I6K12_RS04685	COG3850	Histidine kinase
I6K12_RS04690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K12_RS04700	COG1393	Belongs to the ArsC family
I6K12_RS04715	COG0400	carboxylic ester hydrolase activity
I6K12_RS04725	COG2321	neutral zinc metallopeptidase
I6K12_RS04735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K12_RS04745	COG2716	regulation of RNA biosynthetic process
I6K12_RS04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K12_RS04755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS04760	COG0651	ATP synthesis coupled electron transport
I6K12_RS04765	COG0650	Formate hydrogenlyase subunit 4
I6K12_RS04770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K12_RS04775	COG4237	Hydrogenase 4 membrane
I6K12_RS04780	COG0651	ATP synthesis coupled electron transport
I6K12_RS04785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K12_RS04785	COG3261	NADH dehydrogenase
I6K12_RS04790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K12_RS04795	COG3260	NADH ubiquinone oxidoreductase 20
I6K12_RS04805	COG3604	Transcriptional regulator
I6K12_RS04810	COG2116	formate transmembrane transporter activity
I6K12_RS04815	COG0628	permease
I6K12_RS04820	COG4783	chaperone-mediated protein folding
I6K12_RS04825	COG1393	Belongs to the ArsC family
I6K12_RS04835	COG2233	PERMEase
I6K12_RS04850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K12_RS04855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6K12_RS04860	COG0248	Ppx GppA phosphatase
I6K12_RS04865	COG2200	EAL domain
I6K12_RS04880	COG3133	Outer membrane lipoprotein
I6K12_RS04895	COG0516	GMP reductase activity
I6K12_RS04895	COG0517	IMP dehydrogenase activity
I6K12_RS04920	COG1645	bacterial-type flagellum-dependent swarming motility
I6K12_RS04935	COG2976	Protein conserved in bacteria
I6K12_RS04965	COG4953	penicillin-binding protein 1C
I6K12_RS04970	COG2373	Large extracellular alpha-helical protein
I6K12_RS04975	COG2897	thiosulfate sulfurtransferase activity
I6K12_RS04990	COG2975	iron-sulfur cluster assembly
I6K12_RS04995	COG0633	Ferredoxin
I6K12_RS05015	COG0822	iron-sulfur transferase activity
I6K12_RS05035	COG0483	inositol monophosphate 1-phosphatase activity
I6K12_RS05040	COG1073	alpha beta
I6K12_RS05045	COG3711	transcriptional antiterminator
I6K12_RS05050	COG2814	Major facilitator Superfamily
I6K12_RS05055	COG0583	DNA-binding transcription factor activity
I6K12_RS05060	COG4638	Rieske (2fe-2S)
I6K12_RS05085	COG2259	Doxx family
I6K12_RS05090	COG2017	converts alpha-aldose to the beta-anomer
I6K12_RS05095	COG1063	alcohol dehydrogenase
I6K12_RS05100	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS05105	COG1129	ABC transporter
I6K12_RS05110	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS05115	COG0457	Tetratricopeptide repeat
I6K12_RS05120	COG1940	carbohydrate kinase activity
I6K12_RS05130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K12_RS05130	COG1017	nitric oxide dioxygenase activity
I6K12_RS05135	COG0347	Belongs to the P(II) protein family
I6K12_RS05140	COG2204	response regulator
I6K12_RS05145	COG3170	Tfp pilus assembly protein FimV
I6K12_RS05150	COG2205	protein histidine kinase activity
I6K12_RS05155	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K12_RS05155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K12_RS05170	COG0560	Phosphoserine phosphatase
I6K12_RS05175	COG1737	Transcriptional regulator
I6K12_RS05180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS05195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K12_RS05215	COG0681	Belongs to the peptidase S26 family
I6K12_RS05225	COG3086	response to oxidative stress
I6K12_RS05230	COG3026	antisigma factor binding
I6K12_RS05235	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K12_RS05240	COG1595	DNA-templated transcription, initiation
I6K12_RS05250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K12_RS05260	COG0513	Belongs to the DEAD box helicase family
I6K12_RS05265	COG0583	DNA-binding transcription factor activity
I6K12_RS05285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K12_RS05290	COG3118	belongs to the thioredoxin family
I6K12_RS05295	COG3148	PFAM DTW domain containing protein
I6K12_RS05300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K12_RS05300	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K12_RS05300	COG1042	CoA-binding domain protein
I6K12_RS05305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K12_RS05310	COG5544	Lipoprotein
I6K12_RS05315	COG0477	Major facilitator Superfamily
I6K12_RS05345	COG0542	response to heat
I6K12_RS05355	COG0564	pseudouridine synthase activity
I6K12_RS05360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K12_RS05365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K12_RS05375	COG1605	Chorismate mutase
I6K12_RS05375	COG0077	Prephenate dehydratase
I6K12_RS05380	COG0287	Prephenate dehydrogenase
I6K12_RS05380	COG1605	Chorismate mutase
I6K12_RS05385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K12_RS05400	COG2199	diguanylate cyclase activity
I6K12_RS05405	COG2885	chlorophyll binding
I6K12_RS05430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K12_RS05435	COG4137	Cytochrome C assembly protein
I6K12_RS05440	COG4536	flavin adenine dinucleotide binding
I6K12_RS05455	COG0497	DNA recombination
I6K12_RS05460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K12_RS05470	COG2867	negative regulation of translational initiation
I6K12_RS05485	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS05510	COG0366	Alpha amylase catalytic
I6K12_RS05520	COG0579	oxidoreductase
I6K12_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS05530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K12_RS05535	COG1113	amino acid transport
I6K12_RS05540	COG1802	Transcriptional regulator
I6K12_RS05545	COG1652	LysM domain
I6K12_RS05550	COG0401	homolog of Blt101
I6K12_RS05555	COG0640	Transcriptional regulator
I6K12_RS05560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K12_RS05565	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K12_RS05580	COG4575	ribosome binding
I6K12_RS05585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K12_RS05595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K12_RS05600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K12_RS05605	COG4175	Glycine betaine
I6K12_RS05610	COG4176	ABC-type proline glycine betaine transport system permease component
I6K12_RS05615	COG2113	Glycine betaine
I6K12_RS05620	COG2814	Major facilitator Superfamily
I6K12_RS05625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K12_RS05635	COG1846	Transcriptional regulator
I6K12_RS05640	COG1566	PFAM secretion protein HlyD family protein
I6K12_RS05645	COG2814	Major facilitator Superfamily
I6K12_RS05660	COG1238	metal cluster binding
I6K12_RS05665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K12_RS05695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K12_RS05715	COG1546	Belongs to the CinA family
I6K12_RS05720	COG2951	lytic endotransglycosylase activity
I6K12_RS05725	COG3730	PTS system glucitol sorbitol-specific
I6K12_RS05730	COG3732	PTS system glucitol sorbitol-specific
I6K12_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS05745	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS05750	COG1349	DNA-binding transcription factor activity
I6K12_RS05775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K12_RS05780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS05785	COG1609	Transcriptional regulator
I6K12_RS05790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS05790	COG1263	PTS System
I6K12_RS05795	COG2723	6-phospho-beta-galactosidase activity
I6K12_RS05800	COG5499	transcription regulator containing HTH domain
I6K12_RS05805	COG4680	protein conserved in bacteria
I6K12_RS05810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K12_RS05820	COG3260	NADH ubiquinone oxidoreductase 20
I6K12_RS05825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K12_RS05830	COG3261	NADH dehydrogenase
I6K12_RS05830	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K12_RS05835	COG0650	Formate hydrogenlyase subunit 4
I6K12_RS05840	COG0651	ATP synthesis coupled electron transport
I6K12_RS05845	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS05855	COG0375	protein maturation
I6K12_RS05860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K12_RS05865	COG0298	carbon dioxide binding
I6K12_RS05870	COG0409	Hydrogenase expression formation protein
I6K12_RS05875	COG0309	Hydrogenase expression formation protein (HypE)
I6K12_RS05880	COG3604	Transcriptional regulator
I6K12_RS05905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K12_RS05910	COG1349	DNA-binding transcription factor activity
I6K12_RS05915	COG2084	Dehydrogenase
I6K12_RS05920	COG3395	kinase activity
I6K12_RS05925	COG0235	Class ii aldolase
I6K12_RS05930	COG3622	Belongs to the hyi family
I6K12_RS05935	COG2610	gluconate transmembrane transporter activity
I6K12_RS05945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K12_RS05950	COG0163	prenyltransferase activity
I6K12_RS05960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K12_RS05965	COG4942	peptidase
I6K12_RS05965	COG1388	LysM domain
I6K12_RS06020	COG2234	aminopeptidase activity
I6K12_RS06025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS06030	COG1518	maintenance of DNA repeat elements
I6K12_RS06045	COG1857	crispr-associated protein
I6K12_RS06060	COG1203	CRISPR-associated helicase, Cas3
I6K12_RS06085	COG0720	synthase
I6K12_RS06090	COG0644	oxidoreductase
I6K12_RS06095	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K12_RS06100	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6K12_RS06110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K12_RS06115	COG2086	electron transfer activity
I6K12_RS06120	COG0477	Major facilitator Superfamily
I6K12_RS06125	COG0277	FAD linked oxidase domain protein
I6K12_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS06135	COG2223	nitrite transmembrane transporter activity
I6K12_RS06140	COG1070	Carbohydrate kinase
I6K12_RS06145	COG0602	queuosine metabolic process
I6K12_RS06155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K12_RS06170	COG3956	TIGRFAM MazG family protein
I6K12_RS06175	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6K12_RS06180	COG2336	PFAM SpoVT AbrB
I6K12_RS06185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K12_RS06195	COG3850	Histidine kinase
I6K12_RS06195	COG3437	response regulator, receiver
I6K12_RS06195	COG4999	Histidine kinase
I6K12_RS06195	COG2205	protein histidine kinase activity
I6K12_RS06200	COG4948	Mandelate Racemase Muconate Lactonizing
I6K12_RS06205	COG4948	Mandelate Racemase Muconate Lactonizing
I6K12_RS06210	COG2271	Major facilitator Superfamily
I6K12_RS06215	COG0716	FMN binding
I6K12_RS06220	COG0564	pseudouridine synthase activity
I6K12_RS06225	COG3098	single-species biofilm formation
I6K12_RS06240	COG1611	Belongs to the LOG family
I6K12_RS06245	COG0814	amino acid
I6K12_RS06250	COG1760	l-serine dehydratase
I6K12_RS06260	COG1454	alcohol dehydrogenase
I6K12_RS06265	COG0235	Class ii aldolase
I6K12_RS06275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K12_RS06280	COG1609	Transcriptional regulator
I6K12_RS06285	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS06290	COG1129	ABC transporter
I6K12_RS06300	COG1070	Carbohydrate kinase
I6K12_RS06310	COG1349	DNA-binding transcription factor activity
I6K12_RS06320	COG2363	Small membrane protein
I6K12_RS06325	COG0583	DNA-binding transcription factor activity
I6K12_RS06335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K12_RS06340	COG2166	iron-sulfur cluster assembly
I6K12_RS06345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K12_RS06350	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K12_RS06380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K12_RS06385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS06385	COG1263	PTS System
I6K12_RS06390	COG3711	transcriptional antiterminator
I6K12_RS06395	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K12_RS06400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K12_RS06400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K12_RS06405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K12_RS06410	COG1074	ATP-dependent DNA helicase activity
I6K12_RS06420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K12_RS06425	COG4967	type IV pilus modification protein PilV
I6K12_RS06435	COG4795	General secretion pathway protein
I6K12_RS06440	COG2165	general secretion pathway protein
I6K12_RS06455	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6K12_RS06470	COG0861	Integral membrane protein TerC family
I6K12_RS06480	COG0667	Aldo Keto reductase
I6K12_RS06495	COG1609	Transcriptional regulator
I6K12_RS06505	COG0583	DNA-binding transcription factor activity
I6K12_RS06510	COG1794	racemase activity, acting on amino acids and derivatives
I6K12_RS06515	COG2814	Major facilitator Superfamily
I6K12_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS06530	COG0183	Belongs to the thiolase family
I6K12_RS06535	COG0814	amino acid
I6K12_RS06540	COG2771	luxR family
I6K12_RS06545	COG3710	Transcriptional regulator
I6K12_RS06570	COG0457	Tetratricopeptide repeat
I6K12_RS06575	COG3710	Transcriptional regulator
I6K12_RS06575	COG0457	Tetratricopeptide repeat
I6K12_RS06585	COG0741	lytic transglycosylase activity
I6K12_RS06590	COG2197	response regulator
I6K12_RS06690	COG2207	Transcriptional regulator
I6K12_RS06700	COG3387	PFAM Glycoside hydrolase 15-related
I6K12_RS06710	COG4942	peptidase
I6K12_RS06715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K12_RS06720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K12_RS06725	COG2080	2 iron, 2 sulfur cluster binding
I6K12_RS06730	COG3829	transcription factor binding
I6K12_RS06735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K12_RS06740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K12_RS06745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K12_RS06755	COG0549	Belongs to the carbamate kinase family
I6K12_RS06760	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K12_RS06760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K12_RS06765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K12_RS06770	COG2068	MobA-Related Protein
I6K12_RS06775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS06775	COG0493	'glutamate synthase
I6K12_RS06780	COG0402	S-adenosylhomocysteine deaminase activity
I6K12_RS06785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K12_RS06790	COG2080	2 iron, 2 sulfur cluster binding
I6K12_RS06790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K12_RS06795	COG2233	PERMEase
I6K12_RS06800	COG0402	S-adenosylhomocysteine deaminase activity
I6K12_RS06805	COG2252	PERMEase
I6K12_RS06810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS06815	COG0493	'glutamate synthase
I6K12_RS06815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS06820	COG2233	PERMEase
I6K12_RS06840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K12_RS06850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K12_RS06855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K12_RS06860	COG4974	Belongs to the 'phage' integrase family
I6K12_RS06865	COG0716	FMN binding
I6K12_RS06875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K12_RS06885	COG1272	protein, Hemolysin III
I6K12_RS06895	COG2723	6-phospho-beta-galactosidase activity
I6K12_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS06925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K12_RS06930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K12_RS06935	COG0006	proline dipeptidase activity
I6K12_RS06955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K12_RS06965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K12_RS06980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K12_RS06980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K12_RS06985	COG1703	isobutyryl-CoA mutase activity
I6K12_RS06990	COG1024	Enoyl-CoA hydratase
I6K12_RS06995	COG0427	acetyl-CoA hydrolase
I6K12_RS07000	COG0583	DNA-binding transcription factor activity
I6K12_RS07005	COG2968	Membrane
I6K12_RS07010	COG1279	arginine transmembrane transporter activity
I6K12_RS07015	COG0668	transmembrane transport
I6K12_RS07020	COG0191	fructose-bisphosphate aldolase activity
I6K12_RS07055	COG1122	ATPase activity
I6K12_RS07060	COG1072	(Pantothenic acid kinase))
I6K12_RS07075	COG1063	alcohol dehydrogenase
I6K12_RS07080	COG2213	PTS system mannitol-specific
I6K12_RS07085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS07090	COG0330	HflC and HflK could
I6K12_RS07095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K12_RS07100	COG0501	Belongs to the peptidase M48B family
I6K12_RS07115	COG1166	arginine decarboxylase activity
I6K12_RS07135	COG2814	Major facilitator Superfamily
I6K12_RS07145	COG2356	endonuclease I
I6K12_RS07150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K12_RS07155	COG0189	ligase activity
I6K12_RS07170	COG2805	Type II/IV secretion system protein
I6K12_RS07175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K12_RS07180	COG0762	integral membrane protein
I6K12_RS07190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6K12_RS07195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K12_RS07205	COG0252	asparaginase activity
I6K12_RS07215	COG3171	Protein conserved in bacteria
I6K12_RS07225	COG1194	a g-specific adenine glycosylase
I6K12_RS07230	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6K12_RS07240	COG2211	Major facilitator Superfamily
I6K12_RS07250	COG1982	Orn Lys Arg decarboxylase major
I6K12_RS07255	COG1811	Na channel or pump
I6K12_RS07265	COG0582	viral genome integration into host DNA
I6K12_RS07300	COG2244	polysaccharide biosynthetic process
I6K12_RS07305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K12_RS07310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K12_RS07315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K12_RS07320	COG0306	phosphate transporter
I6K12_RS07325	COG0754	glutathionylspermidine amidase activity
I6K12_RS07330	COG0625	glutathione transferase activity
I6K12_RS07335	COG0298	carbon dioxide binding
I6K12_RS07345	COG1773	rubredoxin
I6K12_RS07350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K12_RS07355	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K12_RS07360	COG5557	Pfam Polysulphide reductase, NrfD
I6K12_RS07365	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS07370	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K12_RS07385	COG0667	Aldo Keto reductase
I6K12_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS07400	COG0848	biopolymer transport protein
I6K12_RS07405	COG0811	peptide transport
I6K12_RS07410	COG0626	cystathionine gamma-synthase activity
I6K12_RS07415	COG0586	Pfam SNARE associated Golgi protein
I6K12_RS07420	COG2207	Transcriptional regulator
I6K12_RS07425	COG1979	alcohol dehydrogenase
I6K12_RS07430	COG0656	L-ascorbic acid biosynthetic process
I6K12_RS07440	COG4238	major outer membrane lipoprotein
I6K12_RS07445	COG1032	radical SAM domain protein
I6K12_RS07450	COG2132	Multicopper oxidase
I6K12_RS07455	COG0204	Acyl-transferase
I6K12_RS07460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K12_RS07465	COG4166	transmembrane transport
I6K12_RS07470	COG2944	sequence-specific DNA binding
I6K12_RS07480	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K12_RS07485	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K12_RS07490	COG0745	RESPONSE REGULATOR receiver
I6K12_RS07495	COG0642	Histidine kinase
I6K12_RS07505	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K12_RS07510	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K12_RS07515	COG0187	DNA topoisomerase II activity
I6K12_RS07520	COG3150	esterase
I6K12_RS07525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K12_RS07530	COG3151	Protein conserved in bacteria
I6K12_RS07535	COG0494	nUDIX hydrolase
I6K12_RS07540	COG1538	Outer membrane efflux protein
I6K12_RS07550	COG0754	glutathionylspermidine amidase activity
I6K12_RS07555	COG3384	dioxygenase
I6K12_RS07575	COG2960	long-chain fatty acid transporting porin activity
I6K12_RS07580	COG3539	Fimbrial protein
I6K12_RS07585	COG3188	usher protein
I6K12_RS07590	COG3121	Chaperone
I6K12_RS07595	COG3539	Fimbrial protein
I6K12_RS07605	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K12_RS07610	COG2268	Band 7 protein
I6K12_RS07635	COG3025	triphosphatase activity
I6K12_RS07640	COG4991	sh3 domain protein
I6K12_RS07655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K12_RS07670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS07675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS07690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K12_RS07695	COG0358	DNA primase activity
I6K12_RS07700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K12_RS07715	COG2375	cellular response to nickel ion
I6K12_RS07720	COG1695	Transcriptional regulator
I6K12_RS07735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K12_RS07740	COG1609	Transcriptional regulator
I6K12_RS07745	COG3250	beta-galactosidase activity
I6K12_RS07750	COG2731	YhcH YjgK YiaL family protein
I6K12_RS07755	COG0531	amino acid
I6K12_RS07765	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K12_RS07765	COG3408	Glycogen debranching enzyme
I6K12_RS07770	COG1902	pentaerythritol trinitrate reductase activity
I6K12_RS07770	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K12_RS07780	COG1451	nucleotide metabolic process
I6K12_RS07785	COG2949	membrane
I6K12_RS07790	COG0673	inositol 2-dehydrogenase activity
I6K12_RS07795	COG0861	Integral membrane protein TerC family
I6K12_RS07800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6K12_RS07810	COG2721	sulfolactate sulfo-lyase activity
I6K12_RS07820	COG2271	Major facilitator Superfamily
I6K12_RS07825	COG2186	Transcriptional regulator
I6K12_RS07830	COG0586	Pfam SNARE associated Golgi protein
I6K12_RS07840	COG1422	Protein of unknown function (DUF1090)
I6K12_RS07845	COG4575	ribosome binding
I6K12_RS07850	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K12_RS07860	COG2259	Doxx family
I6K12_RS07865	COG0435	Glutathione S-transferase
I6K12_RS07870	COG3152	Membrane
I6K12_RS07875	COG3152	Membrane
I6K12_RS07880	COG0583	DNA-binding transcription factor activity
I6K12_RS07885	COG1741	Belongs to the pirin family
I6K12_RS07900	COG0814	amino acid
I6K12_RS07905	COG1760	l-serine dehydratase
I6K12_RS07910	COG0251	oxidation-reduction process
I6K12_RS07915	COG1882	Formate acetyltransferase
I6K12_RS07920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K12_RS07930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K12_RS07935	COG0583	DNA-binding transcription factor activity
I6K12_RS07960	COG1929	Belongs to the glycerate kinase type-1 family
I6K12_RS07965	COG2084	Dehydrogenase
I6K12_RS07975	COG2271	Major facilitator Superfamily
I6K12_RS07980	COG2721	sulfolactate sulfo-lyase activity
I6K12_RS07985	COG2002	toxin-antitoxin pair type II binding
I6K12_RS07995	COG1349	DNA-binding transcription factor activity
I6K12_RS08005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS08015	COG3716	PTS system mannose fructose sorbose family IID component
I6K12_RS08020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS08025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K12_RS08030	COG2222	sugar isomerase
I6K12_RS08040	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS08045	COG3715	PTS system
I6K12_RS08050	COG3716	PTS system mannose fructose sorbose family IID component
I6K12_RS08055	COG0363	glucosamine-6-phosphate deaminase activity
I6K12_RS08060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K12_RS08080	COG2823	Periplasmic or secreted lipoprotein
I6K12_RS08085	COG0701	Predicted permease
I6K12_RS08090	COG0702	epimerase
I6K12_RS08095	COG0693	protein deglycase activity
I6K12_RS08110	COG3153	acetyltransferase
I6K12_RS08115	COG3154	lipid carrier protein
I6K12_RS08120	COG0826	peptidase U32
I6K12_RS08125	COG0826	peptidase U32
I6K12_RS08130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K12_RS08135	COG0814	amino acid
I6K12_RS08140	COG0513	Belongs to the DEAD box helicase family
I6K12_RS08180	COG0195	Participates in both transcription termination and antitermination
I6K12_RS08200	COG2194	sulfuric ester hydrolase activity
I6K12_RS08210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K12_RS08220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K12_RS08225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K12_RS08235	COG1534	Rna-binding protein
I6K12_RS08240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K12_RS08245	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K12_RS08255	COG0697	spore germination
I6K12_RS08270	COG0142	geranyltranstransferase activity
I6K12_RS08275	COG3423	Transcriptional regulator
I6K12_RS08285	COG5007	Belongs to the BolA IbaG family
I6K12_RS08290	COG3113	response to antibiotic
I6K12_RS08295	COG2854	intermembrane phospholipid transfer
I6K12_RS08300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K12_RS08305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K12_RS08310	COG1127	ABC transporter
I6K12_RS08315	COG0530	calcium, potassium:sodium antiporter activity
I6K12_RS08320	COG0517	IMP dehydrogenase activity
I6K12_RS08320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K12_RS08325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K12_RS08330	COG3117	lipopolysaccharide transmembrane transporter activity
I6K12_RS08335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K12_RS08340	COG1137	ATPase activity
I6K12_RS08345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K12_RS08350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K12_RS08365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS08370	COG0515	serine threonine protein kinase
I6K12_RS08380	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K12_RS08385	COG5002	protein histidine kinase activity
I6K12_RS08385	COG2198	Histidine kinase
I6K12_RS08385	COG0784	Response regulator, receiver
I6K12_RS08390	COG1242	4 iron, 4 sulfur cluster binding
I6K12_RS08395	COG0069	glutamate synthase activity
I6K12_RS08395	COG0070	glutamate synthase
I6K12_RS08395	COG0067	glutamate synthase
I6K12_RS08400	COG0493	'glutamate synthase
I6K12_RS08405	COG4804	nuclease activity
I6K12_RS08410	COG2731	YhcH YjgK YiaL family protein
I6K12_RS08445	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K12_RS08450	COG2969	positive regulation of protein catabolic process
I6K12_RS08455	COG0625	glutathione transferase activity
I6K12_RS08470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K12_RS08475	COG3105	Protein conserved in bacteria
I6K12_RS08480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K12_RS08485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K12_RS08505	COG2732	(Barnase) inhibitor
I6K12_RS08525	COG0583	DNA-binding transcription factor activity
I6K12_RS08530	COG0312	modulator of DNA gyrase
I6K12_RS08535	COG3164	Protein of unknown function
I6K12_RS08540	COG1530	ribonuclease E activity
I6K12_RS08550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K12_RS08555	COG1792	Involved in formation and maintenance of cell shape
I6K12_RS08560	COG1077	Cell shape determining protein MreB Mrl
I6K12_RS08565	COG2199	diguanylate cyclase activity
I6K12_RS08565	COG2200	EAL domain
I6K12_RS08570	COG0604	alcohol dehydrogenase
I6K12_RS08575	COG0511	ligase activity, forming carbon-carbon bonds
I6K12_RS08580	COG0439	Biotin carboxylase
I6K12_RS08585	COG3924	membrane
I6K12_RS08590	COG4145	pantothenate transmembrane transporter activity
I6K12_RS08600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K12_RS08610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K12_RS08620	COG1309	transcriptional regulator
I6K12_RS08625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS08630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K12_RS08640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS08645	COG4597	amino acid ABC transporter
I6K12_RS08650	COG0765	amino acid transport
I6K12_RS08655	COG1126	abc transporter atp-binding protein
I6K12_RS08695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K12_RS08715	COG0551	DNA topoisomerase type I activity
I6K12_RS08725	COG0758	DNA mediated transformation
I6K12_RS08745	COG0569	domain protein
I6K12_RS08755	COG3036	rescue of stalled ribosome
I6K12_RS08760	COG0789	Transcriptional regulator
I6K12_RS08800	COG0201	protein transport
I6K12_RS08890	COG0089	rRNA binding
I6K12_RS08960	COG2964	Protein conserved in bacteria
I6K12_RS08965	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K12_RS08975	COG1047	Peptidyl-prolyl cis-trans
I6K12_RS08980	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K12_RS08995	COG0488	(ABC) transporter
I6K12_RS09000	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K12_RS09010	COG3954	Phosphoribulokinase
I6K12_RS09015	COG1765	OsmC-like protein
I6K12_RS09020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K12_RS09025	COG1289	transmembrane transporter activity
I6K12_RS09030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K12_RS09035	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K12_RS09040	COG2184	nucleotidyltransferase activity
I6K12_RS09050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K12_RS09060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K12_RS09065	COG2146	nitrite reductase [NAD(P)H] activity
I6K12_RS09070	COG2116	formate transmembrane transporter activity
I6K12_RS09085	COG0626	cystathionine gamma-synthase activity
I6K12_RS09100	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K12_RS09105	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6K12_RS09110	COG3457	Alanine racemase
I6K12_RS09120	COG2188	Transcriptional regulator
I6K12_RS09125	COG0180	Tryptophanyl-tRNA synthetase
I6K12_RS09130	COG0546	phosphoglycolate phosphatase activity
I6K12_RS09135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K12_RS09140	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K12_RS09145	COG3266	domain, Protein
I6K12_RS09160	COG4796	Type ii and iii secretion system protein
I6K12_RS09175	COG3166	PFAM Fimbrial assembly family protein
I6K12_RS09180	COG4972	Pilus assembly protein
I6K12_RS09185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K12_RS09190	COG0494	nUDIX hydrolase
I6K12_RS09200	COG1011	Hydrolase
I6K12_RS09205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K12_RS09215	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K12_RS09245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K12_RS09250	COG2183	response to ionizing radiation
I6K12_RS09255	COG1918	ferrous iron import across plasma membrane
I6K12_RS09260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6K12_RS09270	COG5464	transposase or invertase
I6K12_RS09280	COG1040	competence protein
I6K12_RS09290	COG2610	gluconate transmembrane transporter activity
I6K12_RS09295	COG1640	4-alpha-glucanotransferase
I6K12_RS09300	COG0058	SHG alpha-glucan phosphorylase activity
I6K12_RS09315	COG1690	Belongs to the RtcB family
I6K12_RS09320	COG4650	regulator
I6K12_RS09325	COG1349	DNA-binding transcription factor activity
I6K12_RS09340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K12_RS09360	COG0058	SHG alpha-glucan phosphorylase activity
I6K12_RS09380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K12_RS09385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K12_RS09390	COG2095	MarC family integral membrane protein
I6K12_RS09395	COG2610	gluconate transmembrane transporter activity
I6K12_RS09400	COG3265	gluconokinase activity
I6K12_RS09405	COG1609	Transcriptional regulator
I6K12_RS09410	COG1741	Belongs to the pirin family
I6K12_RS09415	COG0673	inositol 2-dehydrogenase activity
I6K12_RS09420	COG1247	-acetyltransferase
I6K12_RS09425	COG3157	Type VI secretion system effector, Hcp
I6K12_RS09445	COG0405	Gamma-glutamyltransferase
I6K12_RS09455	COG0584	glycerophosphoryl diester phosphodiesterase
I6K12_RS09470	COG1175	transmembrane transport
I6K12_RS09475	COG1653	transport
I6K12_RS09480	COG0410	ABC transporter
I6K12_RS09485	COG0411	ABC transporter
I6K12_RS09490	COG4177	L-phenylalanine transmembrane transporter activity
I6K12_RS09495	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS09500	COG0683	leucine binding
I6K12_RS09505	COG0456	acetyltransferase
I6K12_RS09510	COG0683	leucine binding
I6K12_RS09515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K12_RS09520	COG2177	Part of the ABC transporter FtsEX involved in
I6K12_RS09525	COG2884	Cell division ATP-binding protein ftsE
I6K12_RS09530	COG0552	protein localization to endoplasmic reticulum
I6K12_RS09535	COG0742	ribosomal rna small subunit methyltransferase
I6K12_RS09540	COG3776	membrane
I6K12_RS09550	COG3714	YhhN family
I6K12_RS09565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K12_RS09580	COG0628	permease
I6K12_RS09585	COG2091	lysine biosynthetic process via aminoadipic acid
I6K12_RS09590	COG0747	negative chemotaxis
I6K12_RS09595	COG0601	transmembrane transport
I6K12_RS09600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K12_RS09620	COG3209	COG3209 Rhs family protein
I6K12_RS09640	COG3209	COG3209 Rhs family protein
I6K12_RS09650	COG1413	lyase activity
I6K12_RS09670	COG0842	Transport permease protein
I6K12_RS09675	COG0842	Transport permease protein
I6K12_RS09675	COG1129	ABC transporter
I6K12_RS09680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS09700	COG2081	HI0933 family
I6K12_RS09705	COG0306	phosphate transporter
I6K12_RS09715	COG0589	response to stress
I6K12_RS09720	COG3104	oligopeptide transport
I6K12_RS09730	COG0339	signal peptide processing
I6K12_RS09735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K12_RS09740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K12_RS09750	COG0640	Transcriptional regulator
I6K12_RS09755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K12_RS09760	COG1393	Belongs to the ArsC family
I6K12_RS09780	COG3065	identical protein binding
I6K12_RS09785	COG2197	response regulator
I6K12_RS09790	COG3720	iron ion transport
I6K12_RS09795	COG4771	TonB-dependent receptor
I6K12_RS09800	COG4558	Periplasmic binding protein
I6K12_RS09810	COG3721	Heme iron utilization protein
I6K12_RS09820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS09830	COG1285	pathogenesis
I6K12_RS09845	COG3247	response to pH
I6K12_RS09850	COG2771	luxR family
I6K12_RS09860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS09865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K12_RS09870	COG2207	Transcriptional regulator
I6K12_RS09880	COG0076	glutamate decarboxylase activity
I6K12_RS09885	COG1858	cytochrome C peroxidase
I6K12_RS09895	COG2197	response regulator
I6K12_RS09900	COG0583	DNA-binding transcription factor activity
I6K12_RS09905	COG1295	ribonuclease BN
I6K12_RS09910	COG0477	Major facilitator Superfamily
I6K12_RS09915	COG2982	Protein involved in outer membrane biogenesis
I6K12_RS09920	COG2200	EAL domain
I6K12_RS09930	COG0612	Peptidase, M16
I6K12_RS09940	COG2199	diguanylate cyclase activity
I6K12_RS09940	COG2200	EAL domain
I6K12_RS09945	COG3118	belongs to the thioredoxin family
I6K12_RS09945	COG0457	Tetratricopeptide repeat
I6K12_RS09950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K12_RS09955	COG1215	transferase activity, transferring glycosyl groups
I6K12_RS09960	COG1215	transferase activity, transferring glycosyl groups
I6K12_RS09975	COG2194	sulfuric ester hydrolase activity
I6K12_RS09995	COG0814	amino acid
I6K12_RS10000	COG4608	Belongs to the ABC transporter superfamily
I6K12_RS10005	COG0444	Belongs to the ABC transporter superfamily
I6K12_RS10010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K12_RS10015	COG0601	transmembrane transport
I6K12_RS10020	COG0747	negative chemotaxis
I6K12_RS10035	COG2194	sulfuric ester hydrolase activity
I6K12_RS10040	COG2223	nitrite transmembrane transporter activity
I6K12_RS10045	COG5571	outer membrane autotransporter
I6K12_RS10050	COG2818	Glycosylase
I6K12_RS10055	COG0456	acetyltransferase
I6K12_RS10060	COG0243	molybdopterin cofactor binding
I6K12_RS10065	COG2885	chlorophyll binding
I6K12_RS10080	COG2944	sequence-specific DNA binding
I6K12_RS10085	COG1278	Cold shock
I6K12_RS10115	COG3274	enterobacterial common antigen metabolic process
I6K12_RS10120	COG4682	membrane
I6K12_RS10125	COG4682	membrane
I6K12_RS10130	COG1070	Carbohydrate kinase
I6K12_RS10140	COG4213	ABC transporter substrate-binding protein
I6K12_RS10150	COG4214	carbohydrate transport
I6K12_RS10155	COG1609	Transcriptional regulator
I6K12_RS10155	COG2207	Transcriptional regulator
I6K12_RS10160	COG2992	FlgJ-related protein
I6K12_RS10165	COG0366	Alpha amylase catalytic
I6K12_RS10170	COG3977	Valine--pyruvate aminotransferase
I6K12_RS10175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K12_RS10180	COG1414	Transcriptional regulator
I6K12_RS10190	COG2731	YhcH YjgK YiaL family protein
I6K12_RS10195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K12_RS10200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K12_RS10205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K12_RS10210	COG1070	Carbohydrate kinase
I6K12_RS10215	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K12_RS10220	COG3623	hexulose-6-phosphate isomerase
I6K12_RS10225	COG0235	Class ii aldolase
I6K12_RS10235	COG2211	Major facilitator Superfamily
I6K12_RS10245	COG3713	MltA-interacting MipA family protein
I6K12_RS10250	COG0583	DNA-binding transcription factor activity
I6K12_RS10255	COG1566	PFAM secretion protein HlyD family protein
I6K12_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS10275	COG1454	alcohol dehydrogenase
I6K12_RS10280	COG3276	selenocysteine insertion sequence binding
I6K12_RS10290	COG0625	glutathione transferase activity
I6K12_RS10295	COG1566	PFAM secretion protein HlyD family protein
I6K12_RS10305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS10305	COG2213	PTS system mannitol-specific
I6K12_RS10315	COG3722	fumarate hydratase activity
I6K12_RS10335	COG5295	Hep Hag repeat protein
I6K12_RS10340	COG1620	l-lactate permease
I6K12_RS10345	COG2186	Transcriptional regulator
I6K12_RS10355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K12_RS10360	COG1045	serine acetyltransferase
I6K12_RS10375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K12_RS10380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K12_RS10390	COG4942	peptidase
I6K12_RS10395	COG2861	carbohydrate metabolic process
I6K12_RS10400	COG1216	Glycosyl transferase, family 2
I6K12_RS10410	COG0156	8-amino-7-oxononanoate synthase activity
I6K12_RS10420	COG0859	PFAM glycosyl transferase family 9
I6K12_RS10425	COG0859	PFAM glycosyl transferase family 9
I6K12_RS10440	COG1442	glycosyl transferase family 8
I6K12_RS10445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K12_RS10460	COG0515	serine threonine protein kinase
I6K12_RS10465	COG0438	transferase activity, transferring glycosyl groups
I6K12_RS10470	COG0859	PFAM glycosyl transferase family 9
I6K12_RS10475	COG1519	Transferase
I6K12_RS10485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K12_RS10505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K12_RS10530	COG1561	YicC-like family, N-terminal region
I6K12_RS10535	COG3645	SOS response
I6K12_RS10540	COG2860	membrane
I6K12_RS10550	COG0194	GDP metabolic process
I6K12_RS10560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K12_RS10565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K12_RS10570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K12_RS10575	COG0786	glutamate:sodium symporter activity
I6K12_RS10580	COG2233	PERMEase
I6K12_RS10585	COG2982	Protein involved in outer membrane biogenesis
I6K12_RS10595	COG1940	carbohydrate kinase activity
I6K12_RS10610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS10610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS10615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS10620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS10620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS10620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS10625	COG3711	transcriptional antiterminator
I6K12_RS10630	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K12_RS10635	COG2211	Major facilitator Superfamily
I6K12_RS10645	COG0582	viral genome integration into host DNA
I6K12_RS10655	COG1609	Transcriptional regulator
I6K12_RS10660	COG2271	Major facilitator Superfamily
I6K12_RS10675	COG2814	Major facilitator Superfamily
I6K12_RS10680	COG0697	spore germination
I6K12_RS10685	COG1464	Belongs to the NlpA lipoprotein family
I6K12_RS10695	COG0457	Tetratricopeptide repeat
I6K12_RS10720	COG1388	LysM domain
I6K12_RS10720	COG4932	domain protein
I6K12_RS10720	COG2373	Large extracellular alpha-helical protein
I6K12_RS10745	COG2252	PERMEase
I6K12_RS10755	COG2271	Major facilitator Superfamily
I6K12_RS10760	COG2271	Major facilitator Superfamily
I6K12_RS10765	COG3851	Histidine kinase
I6K12_RS10770	COG2197	response regulator
I6K12_RS10785	COG0440	acetolactate synthase activity
I6K12_RS10790	COG0028	Belongs to the TPP enzyme family
I6K12_RS10805	COG2814	Major facilitator Superfamily
I6K12_RS10810	COG0641	radical SAM
I6K12_RS10820	COG2149	membrane
I6K12_RS10825	COG3119	arylsulfatase activity
I6K12_RS10830	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K12_RS10835	COG2207	Transcriptional regulator
I6K12_RS10850	COG2188	Transcriptional regulator
I6K12_RS10870	COG5645	(Lipo)protein
I6K12_RS10875	COG0823	Involved in the tonB-independent uptake of proteins
I6K12_RS10880	COG0644	oxidoreductase
I6K12_RS10885	COG2271	Major facilitator Superfamily
I6K12_RS10895	COG0800	Aldolase
I6K12_RS10900	COG3734	2-keto-3-deoxy-galactonokinase
I6K12_RS10905	COG2186	Transcriptional regulator
I6K12_RS10915	COG0561	phosphatase activity
I6K12_RS10920	COG3753	Protein conserved in bacteria
I6K12_RS10925	COG0187	DNA topoisomerase II activity
I6K12_RS10935	COG0592	DNA-directed DNA polymerase activity
I6K12_RS10990	COG0814	amino acid
I6K12_RS11005	COG2091	lysine biosynthetic process via aminoadipic acid
I6K12_RS11010	COG0431	NADPH-dependent FMN reductase
I6K12_RS11015	COG2252	PERMEase
I6K12_RS11020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K12_RS11045	COG0704	Plays a role in the regulation of phosphate uptake
I6K12_RS11050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K12_RS11055	COG0581	inorganic phosphate transmembrane transporter activity
I6K12_RS11060	COG0573	inorganic phosphate transmembrane transporter activity
I6K12_RS11065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K12_RS11120	COG3312	ion transport
I6K12_RS11135	COG0716	FMN binding
I6K12_RS11140	COG1522	sequence-specific DNA binding
I6K12_RS11175	COG1129	ABC transporter
I6K12_RS11180	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS11185	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS11190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS11195	COG1609	Transcriptional regulator
I6K12_RS11200	COG0477	Major facilitator Superfamily
I6K12_RS11205	COG2186	Transcriptional regulator
I6K12_RS11245	COG3085	chromosome segregation
I6K12_RS11250	COG0606	chelatase, subunit chli
I6K12_RS11270	COG3978	acetolactate synthase activity
I6K12_RS11275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K12_RS11285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K12_RS11290	COG0583	DNA-binding transcription factor activity
I6K12_RS11300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K12_RS11305	COG3692	DNA binding
I6K12_RS11310	COG0210	DNA helicase
I6K12_RS11325	COG3118	belongs to the thioredoxin family
I6K12_RS11335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K12_RS11340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K12_RS11345	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K12_RS11350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K12_RS11355	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K12_RS11360	COG0456	acetyltransferase
I6K12_RS11365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K12_RS11370	COG2244	polysaccharide biosynthetic process
I6K12_RS11390	COG1113	amino acid transport
I6K12_RS11415	COG0641	radical SAM
I6K12_RS11420	COG3119	arylsulfatase activity
I6K12_RS11425	COG3071	HemY protein
I6K12_RS11430	COG2959	enzyme of heme biosynthesis
I6K12_RS11435	COG1587	Uroporphyrinogen-III synthase
I6K12_RS11445	COG3072	Adenylate cyclase
I6K12_RS11460	COG5567	small periplasmic lipoprotein
I6K12_RS11470	COG3159	Protein conserved in bacteria
I6K12_RS11480	COG1011	Hydrolase
I6K12_RS11485	COG0210	DNA helicase
I6K12_RS11490	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6K12_RS11495	COG3698	Phosphodiester glycosidase
I6K12_RS11500	COG0598	Magnesium transport protein CorA
I6K12_RS11515	COG2962	Rard protein
I6K12_RS11520	COG2050	protein possibly involved in aromatic compounds catabolism
I6K12_RS11525	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6K12_RS11530	COG0514	ATP-dependent DNA helicase (RecQ)
I6K12_RS11535	COG1280	lysine exporter protein (LysE YggA)
I6K12_RS11540	COG1280	lysine exporter protein (LysE YggA)
I6K12_RS11545	COG2267	carboxylic ester hydrolase activity
I6K12_RS11550	COG0561	phosphatase activity
I6K12_RS11555	COG0697	spore germination
I6K12_RS11560	COG0583	DNA-binding transcription factor activity
I6K12_RS11575	COG3157	Type VI secretion system effector, Hcp
I6K12_RS11580	COG0412	Dienelactone hydrolase
I6K12_RS11585	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6K12_RS11590	COG1322	Protein conserved in bacteria
I6K12_RS11600	COG3165	ubiquinone biosynthetic process from chorismate
I6K12_RS11610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K12_RS11620	COG0805	protein transport
I6K12_RS11630	COG0250	Participates in transcription elongation, termination and antitermination
I6K12_RS11635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K12_RS11640	COG0543	2 iron, 2 sulfur cluster binding
I6K12_RS11660	COG1739	Uncharacterized protein family UPF0029
I6K12_RS11665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K12_RS11670	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K12_RS11705	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K12_RS11710	COG0746	molybdenum cofactor guanylyltransferase activity
I6K12_RS11715	COG3084	Protein conserved in bacteria
I6K12_RS11720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K12_RS11725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K12_RS11735	COG5339	Protein conserved in bacteria
I6K12_RS11740	COG0204	Acyl-transferase
I6K12_RS11745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K12_RS11745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K12_RS11760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K12_RS11770	COG2204	response regulator
I6K12_RS11775	COG3852	Histidine kinase
I6K12_RS11780	COG0174	glutamine synthetase
I6K12_RS11785	COG1217	gtp-binding protein TYPA
I6K12_RS11790	COG2188	Transcriptional regulator
I6K12_RS11795	COG1082	Xylose isomerase domain protein TIM barrel
I6K12_RS11800	COG2271	Major facilitator Superfamily
I6K12_RS11805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K12_RS11810	COG2211	Major facilitator Superfamily
I6K12_RS11815	COG2211	Major facilitator Superfamily
I6K12_RS11820	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K12_RS11830	COG2017	converts alpha-aldose to the beta-anomer
I6K12_RS11835	COG2942	2-epimerase
I6K12_RS11840	COG3684	Belongs to the aldolase LacD family
I6K12_RS11845	COG2084	Dehydrogenase
I6K12_RS11850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS11855	COG1349	DNA-binding transcription factor activity
I6K12_RS11860	COG1011	Hydrolase
I6K12_RS11875	COG0456	acetyltransferase
I6K12_RS11885	COG0657	acetylesterase activity
I6K12_RS11890	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K12_RS11910	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K12_RS11915	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K12_RS11925	COG2864	formate dehydrogenase
I6K12_RS11930	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS11950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS11950	COG3711	transcriptional antiterminator
I6K12_RS11955	COG1363	Peptidase, m42
I6K12_RS11960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS11960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS11965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS12010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K12_RS12020	COG2258	MOSC domain
I6K12_RS12025	COG2205	protein histidine kinase activity
I6K12_RS12030	COG0745	RESPONSE REGULATOR receiver
I6K12_RS12035	COG3678	ATP-independent chaperone mediated protein folding
I6K12_RS12050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K12_RS12070	COG3152	Membrane
I6K12_RS12075	COG3691	Protein conserved in bacteria
I6K12_RS12080	COG0589	response to stress
I6K12_RS12090	COG1494	fructose-1,6-bisphosphatase
I6K12_RS12100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K12_RS12115	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K12_RS12130	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K12_RS12135	COG1609	Transcriptional regulator
I6K12_RS12140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K12_RS12150	COG3209	COG3209 Rhs family protein
I6K12_RS12165	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K12_RS12175	COG0626	cystathionine gamma-synthase activity
I6K12_RS12180	COG0527	aspartate kinase activity
I6K12_RS12180	COG0460	homoserine dehydrogenase
I6K12_RS12190	COG0737	Belongs to the 5'-nucleotidase family
I6K12_RS12195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K12_RS12205	COG0697	spore germination
I6K12_RS12210	COG3738	Protein conserved in bacteria
I6K12_RS12215	COG0371	Dehydrogenase
I6K12_RS12220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K12_RS12225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K12_RS12225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS12225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS12230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS12235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS12240	COG1882	Formate acetyltransferase
I6K12_RS12245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K12_RS12250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS12255	COG2207	Transcriptional regulator
I6K12_RS12260	COG2194	sulfuric ester hydrolase activity
I6K12_RS12275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K12_RS12290	COG0583	DNA-binding transcription factor activity
I6K12_RS12300	COG1309	transcriptional regulator
I6K12_RS12315	COG4206	TonB-dependent receptor
I6K12_RS12350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K12_RS12350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K12_RS12385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K12_RS12390	COG0250	Participates in transcription elongation, termination and antitermination
I6K12_RS12430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K12_RS12440	COG2104	thiamine diphosphate biosynthetic process
I6K12_RS12445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K12_RS12480	COG3068	Protein conserved in bacteria
I6K12_RS12495	COG3678	ATP-independent chaperone mediated protein folding
I6K12_RS12500	COG4191	Histidine kinase
I6K12_RS12505	COG2204	response regulator
I6K12_RS12510	COG0151	Belongs to the GarS family
I6K12_RS12540	COG0456	acetyltransferase
I6K12_RS12550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K12_RS12555	COG2224	Isocitrate lyase
I6K12_RS12570	COG1414	Transcriptional regulator
I6K12_RS12575	COG0646	methionine synthase
I6K12_RS12575	COG1410	methionine synthase
I6K12_RS12580	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K12_RS12630	COG1187	pseudouridine synthase activity
I6K12_RS12640	COG0527	aspartate kinase activity
I6K12_RS12665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K12_RS12680	COG3833	ABC-type maltose transport systems, permease component
I6K12_RS12685	COG1175	transmembrane transport
I6K12_RS12690	COG2182	Extracellular solute-binding protein
I6K12_RS12695	COG3842	ATPase activity
I6K12_RS12710	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K12_RS12730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K12_RS12740	COG0534	Mate efflux family protein
I6K12_RS12745	COG3237	CsbD-like
I6K12_RS12750	COG0735	belongs to the Fur family
I6K12_RS12760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K12_RS12770	COG0604	alcohol dehydrogenase
I6K12_RS12775	COG0305	Participates in initiation and elongation during chromosome replication
I6K12_RS12780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K12_RS12785	COG1448	Aminotransferase
I6K12_RS12795	COG3700	Belongs to the class B bacterial acid phosphatase family
I6K12_RS12800	COG0432	Pfam Uncharacterised protein family UPF0047
I6K12_RS12805	COG2315	Protein conserved in bacteria
I6K12_RS12810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K12_RS12815	COG0629	single-stranded DNA binding
I6K12_RS12825	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K12_RS12830	COG2207	Transcriptional regulator
I6K12_RS12835	COG0789	Transcriptional regulator
I6K12_RS12840	COG2252	PERMEase
I6K12_RS12845	COG0025	NhaP-type Na H and K H
I6K12_RS12850	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K12_RS12860	COG3162	membrane
I6K12_RS12865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K12_RS12875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6K12_RS12880	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS12885	COG3301	Polysulphide reductase, NrfD
I6K12_RS12890	COG1138	Cytochrome C-type biogenesis protein
I6K12_RS12895	COG3088	subunit of a heme lyase
I6K12_RS12900	COG4235	cytochrome complex assembly
I6K12_RS12905	COG1301	dicarboxylic acid transport
I6K12_RS12910	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K12_RS12925	COG1289	transmembrane transporter activity
I6K12_RS12930	COG1566	PFAM secretion protein HlyD family protein
I6K12_RS12940	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K12_RS12945	COG0698	ribose 5-phosphate isomerase
I6K12_RS12955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K12_RS12960	COG0456	acetyltransferase
I6K12_RS12970	COG3454	Phosphonate metabolism
I6K12_RS12975	COG4778	phosphonate C-P lyase system protein PhnL
I6K12_RS12980	COG4107	phosphonate C-P lyase system protein PhnK
I6K12_RS12985	COG3627	carbon phosphorus lyase activity
I6K12_RS12990	COG3626	phosphonate metabolism
I6K12_RS12995	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K12_RS13000	COG3624	Phosphonate C-P lyase system protein PhnG
I6K12_RS13005	COG2188	Transcriptional regulator
I6K12_RS13010	COG3639	organic phosphonate transmembrane transporter activity
I6K12_RS13015	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K12_RS13025	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K12_RS13030	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K12_RS13035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6K12_RS13045	COG0477	Major facilitator Superfamily
I6K12_RS13055	COG0642	Histidine kinase
I6K12_RS13060	COG0745	RESPONSE REGULATOR receiver
I6K12_RS13065	COG2194	sulfuric ester hydrolase activity
I6K12_RS13070	COG0531	amino acid
I6K12_RS13075	COG2207	Transcriptional regulator
I6K12_RS13080	COG1982	Orn Lys Arg decarboxylase major
I6K12_RS13085	COG2169	Transcriptional regulator
I6K12_RS13090	COG1486	melibiose metabolic process
I6K12_RS13095	COG2211	Major facilitator Superfamily
I6K12_RS13100	COG3647	Membrane
I6K12_RS13105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS13105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS13110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K12_RS13115	COG4565	transcriptional regulatory protein
I6K12_RS13120	COG3290	protein histidine kinase activity
I6K12_RS13125	COG3592	Divergent 4Fe-4S mono-cluster
I6K12_RS13130	COG2388	GCN5-related N-acetyl-transferase
I6K12_RS13145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K12_RS13150	COG3104	oligopeptide transport
I6K12_RS13155	COG1982	Orn Lys Arg decarboxylase major
I6K12_RS13160	COG0531	amino acid
I6K12_RS13165	COG3710	Transcriptional regulator
I6K12_RS13175	COG1309	transcriptional regulator
I6K12_RS13180	COG4232	protein-disulfide reductase activity
I6K12_RS13190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K12_RS13195	COG1027	Aspartate ammonia-lyase
I6K12_RS13200	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K12_RS13205	COG0531	amino acid
I6K12_RS13230	COG1509	lysine 2,3-aminomutase activity
I6K12_RS13240	COG5510	response to toxic substance
I6K12_RS13245	COG5510	response to toxic substance
I6K12_RS13255	COG2076	Multidrug Resistance protein
I6K12_RS13260	COG3040	lipid binding
I6K12_RS13265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K12_RS13280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K12_RS13285	COG1053	succinate dehydrogenase
I6K12_RS13295	COG0531	amino acid
I6K12_RS13300	COG3264	Mechanosensitive ion channel
I6K12_RS13300	COG1511	domain protein
I6K12_RS13340	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K12_RS13345	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K12_RS13345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K12_RS13350	COG0802	atpase or kinase
I6K12_RS13355	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K12_RS13375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K12_RS13380	COG0330	HflC and HflK could
I6K12_RS13385	COG0330	HflC and HflK could
I6K12_RS13390	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K12_RS13405	COG0557	exoribonuclease II activity
I6K12_RS13410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K12_RS13415	COG3789	protein conserved in bacteria
I6K12_RS13420	COG1842	Phage shock protein A
I6K12_RS13430	COG3766	membrane
I6K12_RS13435	COG5463	Belongs to the UPF0441 family
I6K12_RS13440	COG0754	glutathionylspermidine amidase activity
I6K12_RS13445	COG1960	acyl-CoA dehydrogenase activity
I6K12_RS13455	COG3650	response to hydrogen peroxide
I6K12_RS13460	COG1073	alpha beta
I6K12_RS13475	COG3037	sugar-specific permease SgaT UlaA
I6K12_RS13480	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K12_RS13520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K12_RS13545	COG0675	Transposase, IS605 OrfB family
I6K12_RS13555	COG3061	Opacity-associated protein A
I6K12_RS13560	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K12_RS13565	COG1113	amino acid transport
I6K12_RS13575	COG0697	spore germination
I6K12_RS13580	COG0702	epimerase
I6K12_RS13585	COG1733	regulation of RNA biosynthetic process
I6K12_RS13590	COG0737	Belongs to the 5'-nucleotidase family
I6K12_RS13595	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6K12_RS13605	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K12_RS13615	COG1253	flavin adenine dinucleotide binding
I6K12_RS13625	COG0729	surface antigen
I6K12_RS13630	COG2911	Protein conserved in bacteria
I6K12_RS13635	COG2105	PFAM AIG2 family protein
I6K12_RS13640	COG2336	PFAM SpoVT AbrB
I6K12_RS13645	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6K12_RS13650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K12_RS13655	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS13660	COG1129	ABC transporter
I6K12_RS13665	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS13670	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS13680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K12_RS13690	COG0312	modulator of DNA gyrase
I6K12_RS13695	COG3783	Cytochrome b(562)
I6K12_RS13700	COG3077	Addiction module antitoxin, RelB DinJ family
I6K12_RS13705	COG2026	Addiction module toxin, RelE StbE family
I6K12_RS13710	COG0602	queuosine metabolic process
I6K12_RS13715	COG1328	CTP reductase activity
I6K12_RS13720	COG0366	Alpha amylase catalytic
I6K12_RS13725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS13725	COG1263	PTS System
I6K12_RS13730	COG1609	Transcriptional regulator
I6K12_RS13740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K12_RS13745	COG0251	oxidation-reduction process
I6K12_RS13765	COG0251	oxidation-reduction process
I6K12_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS13775	COG1309	transcriptional regulator
I6K12_RS13780	COG2731	YhcH YjgK YiaL family protein
I6K12_RS13795	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6K12_RS13805	COG0456	acetyltransferase
I6K12_RS13810	COG4269	membrane
I6K12_RS13815	COG0525	valine-tRNA ligase activity
I6K12_RS13820	COG2927	DNA polymerase III (CHI subunit)
I6K12_RS13830	COG0795	lipopolysaccharide-transporting ATPase activity
I6K12_RS13835	COG0795	lipopolysaccharide-transporting ATPase activity
I6K12_RS13840	COG0433	COG0433 Predicted ATPase
I6K12_RS13845	COG1609	Transcriptional regulator
I6K12_RS13850	COG2610	gluconate transmembrane transporter activity
I6K12_RS13855	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS13860	COG1063	alcohol dehydrogenase
I6K12_RS13865	COG3265	gluconokinase activity
I6K12_RS13870	COG1064	alcohol dehydrogenase
I6K12_RS13895	COG3385	transposase activity
I6K12_RS13900	COG2814	Major facilitator Superfamily
I6K12_RS13905	COG0673	inositol 2-dehydrogenase activity
I6K12_RS13930	COG3344	reverse transcriptase
I6K12_RS13945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K12_RS13960	COG3344	reverse transcriptase
I6K12_RS13970	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6K12_RS13975	COG1120	ATPase activity
I6K12_RS13980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS13985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS13990	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K12_RS13995	COG4772	TonB-dependent receptor
I6K12_RS14000	COG3712	iron ion homeostasis
I6K12_RS14005	COG1595	DNA-templated transcription, initiation
I6K12_RS14040	COG4372	Transposase
I6K12_RS14045	COG3436	PFAM IS66 Orf2 family protein
I6K12_RS14080	COG4983	Phage plasmid primase, P4 family domain protein
I6K12_RS14090	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS14110	COG2003	Belongs to the UPF0758 family
I6K12_RS14150	COG2390	Transcriptional regulator
I6K12_RS14155	COG2610	gluconate transmembrane transporter activity
I6K12_RS14160	COG0129	dihydroxy-acid dehydratase activity
I6K12_RS14165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K12_RS14170	COG1414	Transcriptional regulator
I6K12_RS14175	COG1349	DNA-binding transcription factor activity
I6K12_RS14180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K12_RS14185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS14190	COG0434	BtpA family
I6K12_RS14195	COG3775	system Galactitol-specific IIC component
I6K12_RS14200	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K12_RS14205	COG1363	Peptidase, m42
I6K12_RS14220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K12_RS14225	COG3153	acetyltransferase
I6K12_RS14250	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6K12_RS14255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K12_RS14260	COG0582	viral genome integration into host DNA
I6K12_RS14265	COG4974	Belongs to the 'phage' integrase family
I6K12_RS14270	COG3539	Fimbrial protein
I6K12_RS14275	COG3539	Fimbrial protein
I6K12_RS14280	COG3121	Chaperone
I6K12_RS14285	COG3188	usher protein
I6K12_RS14290	COG3539	Fimbrial protein
I6K12_RS14295	COG3539	Fimbrial protein
I6K12_RS14300	COG3539	Fimbrial protein
I6K12_RS14305	COG2610	gluconate transmembrane transporter activity
I6K12_RS14315	COG0246	Mannitol dehydrogenase
I6K12_RS14320	COG2186	Transcriptional regulator
I6K12_RS14340	COG0583	DNA-binding transcription factor activity
I6K12_RS14345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K12_RS14350	COG0700	Nucleoside recognition
I6K12_RS14355	COG3366	ferrous iron transmembrane transporter activity
I6K12_RS14365	COG0477	Major facilitator Superfamily
I6K12_RS14380	COG1924	4 iron, 4 sulfur cluster binding
I6K12_RS14385	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K12_RS14390	COG2733	membrane
I6K12_RS14400	COG5457	Domain of unknown function (DUF1127)
I6K12_RS14415	COG0732	type I restriction modification DNA specificity domain
I6K12_RS14420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K12_RS14425	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K12_RS14430	COG1715	Restriction endonuclease
I6K12_RS14435	COG0523	cobalamin synthesis protein
I6K12_RS14440	COG2879	small protein
I6K12_RS14445	COG1966	Carbon starvation protein
I6K12_RS14450	COG0840	transmembrane signaling receptor activity
I6K12_RS14455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K12_RS14465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K12_RS14470	COG0025	NhaP-type Na H and K H
I6K12_RS14495	COG1484	DNA-dependent DNA replication
I6K12_RS14510	COG2966	Psort location CytoplasmicMembrane, score
I6K12_RS14515	COG2197	response regulator
I6K12_RS14520	COG2197	response regulator
I6K12_RS14525	COG4114	ferric iron reductase
I6K12_RS14555	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K12_RS14560	COG0456	acetyltransferase
I6K12_RS14565	COG1011	Hydrolase
I6K12_RS14575	COG2823	Periplasmic or secreted lipoprotein
I6K12_RS14585	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K12_RS14590	COG0084	hydrolase, TatD family'
I6K12_RS14595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K12_RS14600	COG1328	CTP reductase activity
I6K12_RS14635	COG3726	membrane protein affecting hemolysin expression
I6K12_RS14640	COG0560	Phosphoserine phosphatase
I6K12_RS14645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K12_RS14650	COG3172	ATPase kinase involved in NAD metabolism
I6K12_RS14650	COG1056	cytidyltransferase-related domain
I6K12_RS14655	COG1902	pentaerythritol trinitrate reductase activity
I6K12_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS14680	COG0583	DNA-binding transcription factor activity
I6K12_RS14690	COG0488	(ABC) transporter
I6K12_RS14695	COG0741	lytic transglycosylase activity
I6K12_RS14715	COG3708	Transcriptional regulator
I6K12_RS14715	COG2207	Transcriptional regulator
I6K12_RS14720	COG3045	CreA protein
I6K12_RS14725	COG0745	RESPONSE REGULATOR receiver
I6K12_RS14730	COG2205	protein histidine kinase activity
I6K12_RS14735	COG4452	Inner membrane protein CreD
I6K12_RS14745	COG0745	RESPONSE REGULATOR receiver
I6K12_RS14755	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K12_RS14765	COG0527	aspartate kinase activity
I6K12_RS14765	COG0460	homoserine dehydrogenase
I6K12_RS14775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K12_RS14790	COG1115	amino acid carrier protein
I6K12_RS14800	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K12_RS14805	COG1584	GPR1 FUN34 yaaH family protein
I6K12_RS14810	COG4735	regulation of single-species biofilm formation
I6K12_RS14840	COG0583	DNA-binding transcription factor activity
I6K12_RS14850	COG3188	usher protein
I6K12_RS14855	COG3121	Chaperone
I6K12_RS14880	COG0196	riboflavin kinase activity
I6K12_RS14895	COG1047	Peptidyl-prolyl cis-trans
I6K12_RS14920	COG0505	Belongs to the CarA family
I6K12_RS14925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K12_RS14975	COG0644	oxidoreductase
I6K12_RS14985	COG2271	Major facilitator Superfamily
I6K12_RS15000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K12_RS15035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K12_RS15045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K12_RS15050	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K12_RS15060	COG0564	pseudouridine synthase activity
I6K12_RS15070	COG0417	DNA replication proofreading
I6K12_RS15075	COG0235	Class ii aldolase
I6K12_RS15090	COG4977	sequence-specific DNA binding
I6K12_RS15095	COG0586	Pfam SNARE associated Golgi protein
I6K12_RS15105	COG1178	ABC-type Fe3 transport system permease component
I6K12_RS15110	COG4143	(ABC) transporter
I6K12_RS15155	COG0583	DNA-binding transcription factor activity
I6K12_RS15165	COG0028	Belongs to the TPP enzyme family
I6K12_RS15170	COG0440	acetolactate synthase activity
I6K12_RS15180	COG1609	Transcriptional regulator
I6K12_RS15195	COG3116	cell division
I6K12_RS15200	COG0768	penicillin binding
I6K12_RS15205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K12_RS15210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K12_RS15225	COG0772	Belongs to the SEDS family
I6K12_RS15240	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K12_RS15245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K12_RS15250	COG0849	cell division
I6K12_RS15255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K12_RS15275	COG0494	nUDIX hydrolase
I6K12_RS15290	COG0237	dephospho-CoA kinase activity
I6K12_RS15305	COG1459	type II secretion system
I6K12_RS15310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K12_RS15315	COG4969	Belongs to the N-Me-Phe pilin family
I6K12_RS15320	COG0157	Belongs to the NadC ModD family
I6K12_RS15325	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K12_RS15330	COG3725	Membrane protein required for beta-lactamase induction
I6K12_RS15340	COG2186	Transcriptional regulator
I6K12_RS15345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K12_RS15350	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K12_RS15355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K12_RS15360	COG3064	Membrane
I6K12_RS15365	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6K12_RS15390	COG2132	Multicopper oxidase
I6K12_RS15395	COG4993	Dehydrogenase
I6K12_RS15400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K12_RS15405	COG0288	reversible hydration of carbon dioxide
I6K12_RS15410	COG1131	(ABC) transporter
I6K12_RS15415	COG0842	Transport permease protein
I6K12_RS15420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS15425	COG0726	polysaccharide deacetylase
I6K12_RS15435	COG5464	transposase or invertase
I6K12_RS15450	COG3539	Fimbrial protein
I6K12_RS15455	COG3539	Fimbrial protein
I6K12_RS15460	COG3539	Fimbrial protein
I6K12_RS15465	COG3188	usher protein
I6K12_RS15470	COG3121	Chaperone
I6K12_RS15475	COG3539	Fimbrial protein
I6K12_RS15480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K12_RS15485	COG0617	tRNA 3'-terminal CCA addition
I6K12_RS15490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K12_RS15495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K12_RS15505	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K12_RS15510	COG1643	Atp-dependent helicase
I6K12_RS15515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K12_RS15520	COG4774	siderophore transport
I6K12_RS15525	COG1120	ATPase activity
I6K12_RS15530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K12_RS15535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS15560	COG2860	membrane
I6K12_RS15565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K12_RS15580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K12_RS15585	COG3835	regulator
I6K12_RS15605	COG0024	Methionine aminopeptidase
I6K12_RS15630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K12_RS15635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K12_RS15640	COG0575	Belongs to the CDS family
I6K12_RS15645	COG0750	zinc metalloprotease
I6K12_RS15655	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K12_RS15660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K12_RS15685	COG0587	DNA-directed DNA polymerase activity
I6K12_RS15695	COG1982	Orn Lys Arg decarboxylase major
I6K12_RS15700	COG0346	lactoylglutathione lyase activity
I6K12_RS15705	COG0037	tRNA processing
I6K12_RS15710	COG4568	rho-dependent transcription termination
I6K12_RS15720	COG4681	YaeQ
I6K12_RS15725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K12_RS15730	COG3015	lipoprotein NlpE involved in copper resistance
I6K12_RS15735	COG0791	NLP P60 protein
I6K12_RS15745	COG1720	tRNA m6t6A37 methyltransferase activity
I6K12_RS15755	COG1464	Belongs to the NlpA lipoprotein family
I6K12_RS15760	COG2011	ABC-type metal ion transport system permease component
I6K12_RS15765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K12_RS15770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K12_RS15805	COG0656	L-ascorbic acid biosynthetic process
I6K12_RS15810	COG0583	DNA-binding transcription factor activity
I6K12_RS15820	COG2226	methyltransferase
I6K12_RS15825	COG0741	lytic transglycosylase activity
I6K12_RS15825	COG1388	LysM domain
I6K12_RS15835	COG2226	methyltransferase
I6K12_RS15845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS15865	COG4104	PAAR repeat-containing protein
I6K12_RS15870	COG3157	Type VI secretion system effector, Hcp
I6K12_RS15970	COG3209	COG3209 Rhs family protein
I6K12_RS15990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K12_RS16000	COG1960	acyl-CoA dehydrogenase activity
I6K12_RS16010	COG0121	glutamine amidotransferase
I6K12_RS16015	COG3034	peptidoglycan biosynthetic process
I6K12_RS16020	COG0791	NLP P60 protein
I6K12_RS16045	COG2161	toxin-antitoxin pair type II binding
I6K12_RS16055	COG0454	-acetyltransferase
I6K12_RS16070	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K12_RS16090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K12_RS16145	COG0583	DNA-binding transcription factor activity
I6K12_RS16160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K12_RS16165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K12_RS16170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K12_RS16175	COG2080	2 iron, 2 sulfur cluster binding
I6K12_RS16180	COG3477	response to acidic pH
I6K12_RS16185	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K12_RS16240	COG1902	pentaerythritol trinitrate reductase activity
I6K12_RS16250	COG1073	alpha beta
I6K12_RS16255	COG0583	DNA-binding transcription factor activity
I6K12_RS16265	COG0667	Aldo Keto reductase
I6K12_RS16270	COG0656	L-ascorbic acid biosynthetic process
I6K12_RS16275	COG1388	LysM domain
I6K12_RS16280	COG2207	Transcriptional regulator
I6K12_RS16280	COG3708	Transcriptional regulator
I6K12_RS16285	COG0656	L-ascorbic acid biosynthetic process
I6K12_RS16290	COG3059	membrane
I6K12_RS16300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K12_RS16305	COG2207	Transcriptional regulator
I6K12_RS16315	COG1139	Iron-sulfur cluster binding protein
I6K12_RS16320	COG1556	Lactate utilization protein
I6K12_RS16345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K12_RS16350	COG2771	luxR family
I6K12_RS16350	COG2200	EAL domain
I6K12_RS16355	COG0583	DNA-binding transcription factor activity
I6K12_RS16365	COG0666	response to abiotic stimulus
I6K12_RS16375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K12_RS16380	COG1304	FMN binding
I6K12_RS16385	COG0549	Belongs to the carbamate kinase family
I6K12_RS16390	COG0402	S-adenosylhomocysteine deaminase activity
I6K12_RS16400	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS16405	COG1129	ABC transporter
I6K12_RS16410	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K12_RS16420	COG1064	alcohol dehydrogenase
I6K12_RS16435	COG1280	lysine exporter protein (LysE YggA)
I6K12_RS16445	COG3829	transcription factor binding
I6K12_RS16450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K12_RS16455	COG0372	Belongs to the citrate synthase family
I6K12_RS16460	COG2079	MmgE PrpD family protein
I6K12_RS16465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K12_RS16470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K12_RS16475	COG0402	S-adenosylhomocysteine deaminase activity
I6K12_RS16480	COG0583	DNA-binding transcription factor activity
I6K12_RS16485	COG0288	reversible hydration of carbon dioxide
I6K12_RS16495	COG2807	transmembrane transport
I6K12_RS16500	COG0110	maltose O-acetyltransferase activity
I6K12_RS16505	COG2223	nitrite transmembrane transporter activity
I6K12_RS16515	COG1609	Transcriptional regulator
I6K12_RS16520	COG1414	Transcriptional regulator
I6K12_RS16555	COG2814	Major facilitator Superfamily
I6K12_RS16560	COG3122	Protein conserved in bacteria
I6K12_RS16590	COG1215	transferase activity, transferring glycosyl groups
I6K12_RS16595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K12_RS16600	COG4521	taurine ABC transporter
I6K12_RS16605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K12_RS16610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K12_RS16615	COG2175	clavaminate synthase activity
I6K12_RS16620	COG0113	porphobilinogen synthase activity
I6K12_RS16625	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS16630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K12_RS16635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K12_RS16640	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K12_RS16660	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K12_RS16675	COG1785	Belongs to the alkaline phosphatase family
I6K12_RS16685	COG3706	GGDEF domain
I6K12_RS16690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K12_RS16710	COG4126	flavin adenine dinucleotide binding
I6K12_RS16735	COG1940	carbohydrate kinase activity
I6K12_RS16745	COG2814	Major facilitator Superfamily
I6K12_RS16750	COG0419	ATPase involved in DNA repair
I6K12_RS16755	COG0420	3'-5' exonuclease activity
I6K12_RS16760	COG0745	RESPONSE REGULATOR receiver
I6K12_RS16765	COG5002	protein histidine kinase activity
I6K12_RS16770	COG1114	Component of the transport system for branched-chain amino acids
I6K12_RS16775	COG1113	amino acid transport
I6K12_RS16780	COG0366	Alpha amylase catalytic
I6K12_RS16805	COG1862	Preprotein translocase
I6K12_RS16810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K12_RS16815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K12_RS16825	COG1403	HNH endonuclease
I6K12_RS16830	COG3248	Nucleoside-binding outer membrane protein
I6K12_RS16845	COG0675	Transposase, IS605 OrfB family
I6K12_RS16860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K12_RS16860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K12_RS16875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K12_RS16880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K12_RS16890	COG0667	Aldo Keto reductase
I6K12_RS16900	COG0142	geranyltranstransferase activity
I6K12_RS16915	COG0693	protein deglycase activity
I6K12_RS16920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K12_RS16930	COG2814	Major facilitator Superfamily
I6K12_RS16940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K12_RS16945	COG1845	cytochrome c oxidase, subunit III
I6K12_RS16950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K12_RS16955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K12_RS16960	COG2223	nitrite transmembrane transporter activity
I6K12_RS16965	COG3056	Lipoprotein
I6K12_RS16970	COG0271	Belongs to the BolA IbaG family
I6K12_RS16990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K12_RS16995	COG0776	regulation of translation
I6K12_RS17000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K12_RS17005	COG1555	photosystem II stabilization
I6K12_RS17010	COG0824	Thioesterase
I6K12_RS17020	COG4533	DNA binding
I6K12_RS17030	COG1522	sequence-specific DNA binding
I6K12_RS17035	COG1132	(ABC) transporter
I6K12_RS17040	COG1132	(ABC) transporter
I6K12_RS17045	COG0347	Belongs to the P(II) protein family
I6K12_RS17050	COG0004	ammonium transporteR
I6K12_RS17055	COG1946	Acyl-CoA thioesterase
I6K12_RS17060	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K12_RS17065	COG3695	enzyme binding
I6K12_RS17075	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K12_RS17080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K12_RS17090	COG0110	maltose O-acetyltransferase activity
I6K12_RS17105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K12_RS17110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS17115	COG1309	transcriptional regulator
I6K12_RS17120	COG3264	Mechanosensitive ion channel
I6K12_RS17120	COG1196	nuclear chromosome segregation
I6K12_RS17130	COG3923	Primosomal replication protein n
I6K12_RS17135	COG2832	Protein of unknown function (DUF454)
I6K12_RS17145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K12_RS17180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K12_RS17190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K12_RS17190	COG4651	solute:proton antiporter activity
I6K12_RS17195	COG2223	nitrite transmembrane transporter activity
I6K12_RS17200	COG0737	Belongs to the 5'-nucleotidase family
I6K12_RS17205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K12_RS17210	COG3735	TraB family
I6K12_RS17215	COG2217	Heavy metal translocating P-type atpase
I6K12_RS17225	COG0531	amino acid
I6K12_RS17250	COG0789	Transcriptional regulator
I6K12_RS17270	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K12_RS17275	COG0330	HflC and HflK could
I6K12_RS17280	COG4619	ABC transporter
I6K12_RS17285	COG0390	transport system, permease component
I6K12_RS17290	COG3118	belongs to the thioredoxin family
I6K12_RS17295	COG0300	oxidoreductase activity
I6K12_RS17300	COG2755	lipolytic protein G-D-S-L family
I6K12_RS17305	COG4181	ATPase activity
I6K12_RS17310	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K12_RS17315	COG3209	COG3209 Rhs family protein
I6K12_RS17340	COG0583	DNA-binding transcription factor activity
I6K12_RS17350	COG1414	Transcriptional regulator
I6K12_RS17355	COG3960	tartronate-semialdehyde synthase activity
I6K12_RS17360	COG3622	Belongs to the hyi family
I6K12_RS17365	COG2084	Dehydrogenase
I6K12_RS17370	COG1953	Uracil, thiamine, allantoin
I6K12_RS17380	COG2233	PERMEase
I6K12_RS17385	COG1929	Belongs to the glycerate kinase type-1 family
I6K12_RS17390	COG3257	ureidoglycine aminohydrolase activity
I6K12_RS17395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K12_RS17405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K12_RS17410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K12_RS17420	COG0549	Belongs to the carbamate kinase family
I6K12_RS17425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K12_RS17430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K12_RS17440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K12_RS17450	COG1988	membrane-bound metal-dependent
I6K12_RS17455	COG2501	S4 domain
I6K12_RS17465	COG3539	Fimbrial protein
I6K12_RS17470	COG3121	Chaperone
I6K12_RS17475	COG3188	usher protein
I6K12_RS17480	COG3539	Fimbrial protein
I6K12_RS17485	COG3539	Fimbrial protein
I6K12_RS17490	COG2197	response regulator
I6K12_RS17500	COG2207	Transcriptional regulator
I6K12_RS17510	COG4783	chaperone-mediated protein folding
I6K12_RS17520	COG5433	transposase activity
I6K12_RS17535	COG4104	PAAR repeat-containing protein
I6K12_RS17535	COG3209	COG3209 Rhs family protein
I6K12_RS17580	COG5002	protein histidine kinase activity
I6K12_RS17585	COG0745	RESPONSE REGULATOR receiver
I6K12_RS17590	COG1538	Outer membrane efflux protein
I6K12_RS17595	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS17600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS17605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K12_RS17610	COG1113	amino acid transport
I6K12_RS17620	COG0668	transmembrane transport
I6K12_RS17625	COG0778	Nitroreductase
I6K12_RS17630	COG2315	Protein conserved in bacteria
I6K12_RS17655	COG2977	Belongs to the P-Pant transferase superfamily
I6K12_RS17660	COG4771	TonB-dependent receptor
I6K12_RS17665	COG2382	esterase
I6K12_RS17670	COG3251	PFAM MbtH domain protein
I6K12_RS17675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K12_RS17675	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K12_RS17680	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K12_RS17685	COG1120	ATPase activity
I6K12_RS17690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS17695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS17705	COG4592	Periplasmic binding protein
I6K12_RS17710	COG1169	isochorismate synthase
I6K12_RS17715	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K12_RS17720	COG3433	isochorismatase activity
I6K12_RS17720	COG1535	isochorismatase
I6K12_RS17725	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS17730	COG2050	protein possibly involved in aromatic compounds catabolism
I6K12_RS17735	COG1966	Carbon starvation protein
I6K12_RS17740	COG2879	small protein
I6K12_RS17745	COG0371	Dehydrogenase
I6K12_RS17750	COG0436	Aminotransferase
I6K12_RS17755	COG1475	DNA binding
I6K12_RS17760	COG3969	phosphoadenosine phosphosulfate
I6K12_RS17770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K12_RS17775	COG0450	alkyl hydroperoxide reductase
I6K12_RS17780	COG3634	alkyl hydroperoxide reductase activity
I6K12_RS17785	COG0589	response to stress
I6K12_RS17790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K12_RS17795	COG3719	Belongs to the RNase T2 family
I6K12_RS17800	COG0471	metal ion transport
I6K12_RS17815	COG3051	citrate lyase alpha subunit
I6K12_RS17820	COG2301	Belongs to the HpcH HpaI aldolase family
I6K12_RS17830	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6K12_RS17835	COG3290	protein histidine kinase activity
I6K12_RS17840	COG4565	transcriptional regulatory protein
I6K12_RS17845	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K12_RS17865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K12_RS17870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K12_RS17880	COG0583	DNA-binding transcription factor activity
I6K12_RS17895	COG1686	Belongs to the peptidase S11 family
I6K12_RS17900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K12_RS17905	COG0772	Belongs to the SEDS family
I6K12_RS17910	COG0768	penicillin binding
I6K12_RS17920	COG0799	negative regulation of ribosome biogenesis
I6K12_RS17925	COG0406	alpha-ribazole phosphatase activity
I6K12_RS17935	COG1466	dna polymerase III delta subunit
I6K12_RS17950	COG2888	peptidyl-tyrosine sulfation
I6K12_RS17960	COG1126	abc transporter atp-binding protein
I6K12_RS17965	COG0765	amino acid transport
I6K12_RS17970	COG0765	amino acid transport
I6K12_RS17975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS17980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6K12_RS17985	COG4535	Mg2 and Co2 transporter CorC
I6K12_RS17995	COG1702	phosphate starvation-inducible protein PhoH
I6K12_RS18005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K12_RS18045	COG0367	asparagine synthase
I6K12_RS18050	COG0647	UMP catabolic process
I6K12_RS18055	COG1846	Transcriptional regulator
I6K12_RS18055	COG1940	carbohydrate kinase activity
I6K12_RS18060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K12_RS18070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS18070	COG1263	PTS System
I6K12_RS18070	COG2190	(PTS) system
I6K12_RS18095	COG0735	belongs to the Fur family
I6K12_RS18105	COG0716	FMN binding
I6K12_RS18115	COG0596	Alpha beta hydrolase
I6K12_RS18120	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K12_RS18125	COG0033	Phosphoglucomutase
I6K12_RS18130	COG0531	amino acid
I6K12_RS18135	COG1982	Orn Lys Arg decarboxylase major
I6K12_RS18145	COG0745	RESPONSE REGULATOR receiver
I6K12_RS18150	COG2205	protein histidine kinase activity
I6K12_RS18180	COG3209	COG3209 Rhs family protein
I6K12_RS18190	COG3209	COG3209 Rhs family protein
I6K12_RS18200	COG3272	Protein of unknown function (DUF1722)
I6K12_RS18205	COG0415	Belongs to the DNA photolyase family
I6K12_RS18215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K12_RS18220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K12_RS18225	COG1984	allophanate hydrolase subunit 2
I6K12_RS18240	COG3180	Ammonia monooxygenase
I6K12_RS18245	COG3539	Fimbrial protein
I6K12_RS18250	COG3121	Chaperone
I6K12_RS18255	COG3188	usher protein
I6K12_RS18260	COG3539	Fimbrial protein
I6K12_RS18265	COG0372	Belongs to the citrate synthase family
I6K12_RS18275	COG2009	succinate dehydrogenase
I6K12_RS18280	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K12_RS18285	COG1053	succinate dehydrogenase
I6K12_RS18290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K12_RS18295	COG0567	Dehydrogenase, E1 component
I6K12_RS18300	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K12_RS18310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K12_RS18315	COG2188	Transcriptional regulator
I6K12_RS18320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS18320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS18320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K12_RS18325	COG0383	alpha-mannosidase activity
I6K12_RS18335	COG0583	DNA-binding transcription factor activity
I6K12_RS18340	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K12_RS18345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS18345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS18350	COG1301	dicarboxylic acid transport
I6K12_RS18365	COG3799	methylaspartate ammonia-lyase activity
I6K12_RS18370	COG4865	methylaspartate mutase activity
I6K12_RS18380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K12_RS18395	COG1271	oxidase subunit
I6K12_RS18400	COG1294	oxidase, subunit
I6K12_RS18405	COG4890	Cyd operon protein YbgT
I6K12_RS18410	COG3790	cyd operon protein YbgE
I6K12_RS18415	COG0824	Thioesterase
I6K12_RS18420	COG0811	peptide transport
I6K12_RS18425	COG0848	biopolymer transport protein
I6K12_RS18430	COG3064	Membrane
I6K12_RS18440	COG2885	chlorophyll binding
I6K12_RS18445	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K12_RS18495	COG3201	nicotinamide mononucleotide transporter
I6K12_RS18500	COG1230	cation diffusion facilitator family transporter
I6K12_RS18510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K12_RS18520	COG2017	converts alpha-aldose to the beta-anomer
I6K12_RS18530	COG1085	galactose-1-phosphate uridylyltransferase
I6K12_RS18535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K12_RS18540	COG1119	ATPase activity
I6K12_RS18545	COG2005	Transcriptional regulator
I6K12_RS18545	COG3585	molybdate ion transport
I6K12_RS18555	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K12_RS18560	COG4149	molybdate abc transporter
I6K12_RS18565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K12_RS18570	COG0561	phosphatase activity
I6K12_RS18580	COG0583	DNA-binding transcription factor activity
I6K12_RS18585	COG2828	Protein conserved in bacteria
I6K12_RS18590	COG0471	metal ion transport
I6K12_RS18595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K12_RS18600	COG4677	pectinesterase activity
I6K12_RS18605	COG1881	PFAM PEBP family protein
I6K12_RS18610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K12_RS18625	COG2226	methyltransferase
I6K12_RS18630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K12_RS18640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K12_RS18650	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K12_RS18660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K12_RS18665	COG0314	molybdopterin synthase activity
I6K12_RS18670	COG0670	Belongs to the BI1 family
I6K12_RS18680	COG0670	Belongs to the BI1 family
I6K12_RS18685	COG0392	lysyltransferase activity
I6K12_RS18690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K12_RS18695	COG3568	Endonuclease Exonuclease Phosphatase
I6K12_RS18705	COG0842	Transport permease protein
I6K12_RS18710	COG0842	Transport permease protein
I6K12_RS18715	COG1131	(ABC) transporter
I6K12_RS18725	COG1309	transcriptional regulator
I6K12_RS18730	COG0513	Belongs to the DEAD box helicase family
I6K12_RS18745	COG1199	ATP-dependent helicase activity
I6K12_RS18750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K12_RS18755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K12_RS18765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K12_RS18775	COG4774	siderophore transport
I6K12_RS18790	COG0668	transmembrane transport
I6K12_RS18795	COG1126	abc transporter atp-binding protein
I6K12_RS18800	COG0765	amino acid transport
I6K12_RS18805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS18815	COG5006	permease, DMT superfamily
I6K12_RS18825	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K12_RS18830	COG2194	sulfuric ester hydrolase activity
I6K12_RS18840	COG1321	iron dependent repressor
I6K12_RS18845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K12_RS18850	COG1376	ErfK ybiS ycfS ynhG family protein
I6K12_RS18855	COG0488	(ABC) transporter
I6K12_RS18865	COG2271	Major facilitator Superfamily
I6K12_RS18880	COG0561	phosphatase activity
I6K12_RS18885	COG1882	Formate acetyltransferase
I6K12_RS18890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K12_RS18895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K12_RS18900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K12_RS18905	COG0303	'Molybdopterin
I6K12_RS18910	COG1446	asparaginase
I6K12_RS18920	COG0747	negative chemotaxis
I6K12_RS18935	COG2200	EAL domain
I6K12_RS18965	COG2133	pyrroloquinoline quinone binding
I6K12_RS18970	COG0625	glutathione transferase activity
I6K12_RS18975	COG1686	Belongs to the peptidase S11 family
I6K12_RS18980	COG1349	DNA-binding transcription factor activity
I6K12_RS18985	COG0671	phosphoesterase, PA-phosphatase related
I6K12_RS18990	COG2814	Major facilitator Superfamily
I6K12_RS19000	COG0561	phosphatase activity
I6K12_RS19005	COG0738	Major facilitator superfamily
I6K12_RS19010	COG3226	Transcriptional regulator
I6K12_RS19025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K12_RS19035	COG0778	Nitroreductase
I6K12_RS19050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K12_RS19055	COG3842	ATPase activity
I6K12_RS19060	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K12_RS19065	COG1177	transmembrane transport
I6K12_RS19075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6K12_RS19080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS19085	COG4160	amino acid transport
I6K12_RS19090	COG4215	(ABC) transporter
I6K12_RS19095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K12_RS19100	COG1126	abc transporter atp-binding protein
I6K12_RS19120	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K12_RS19125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K12_RS19130	COG0702	epimerase
I6K12_RS19135	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K12_RS19140	COG0028	Belongs to the TPP enzyme family
I6K12_RS19145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K12_RS19155	COG2431	L-lysine efflux transmembrane transporter activity
I6K12_RS19160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K12_RS19165	COG3593	DNA synthesis involved in DNA repair
I6K12_RS19170	COG2990	Protein conserved in bacteria
I6K12_RS19175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS19185	COG1278	Cold shock
I6K12_RS19195	COG0542	response to heat
I6K12_RS19220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K12_RS19225	COG4988	ABC transporter
I6K12_RS19230	COG0492	ferredoxin-NADP+ reductase activity
I6K12_RS19235	COG1522	sequence-specific DNA binding
I6K12_RS19240	COG1674	ftsk spoiiie
I6K12_RS19240	COG1178	ABC-type Fe3 transport system permease component
I6K12_RS19250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K12_RS19260	COG0243	molybdopterin cofactor binding
I6K12_RS19265	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS19270	COG3302	dmso reductase anchor subunit
I6K12_RS19275	COG1335	isochorismatase
I6K12_RS19285	COG0531	amino acid
I6K12_RS19295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K12_RS19300	COG1882	Formate acetyltransferase
I6K12_RS19305	COG2116	formate transmembrane transporter activity
I6K12_RS19310	COG1944	ATP diphosphatase activity
I6K12_RS19315	COG2323	membrane
I6K12_RS19330	COG0501	Belongs to the peptidase M48B family
I6K12_RS19340	COG0539	negative regulation of cytoplasmic translation
I6K12_RS19350	COG2333	competence protein COMEC
I6K12_RS19350	COG0658	competence protein
I6K12_RS19355	COG1132	(ABC) transporter
I6K12_RS19365	COG3214	Protein conserved in bacteria
I6K12_RS19380	COG3173	Aminoglycoside phosphotransferase
I6K12_RS19385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K12_RS19390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K12_RS19400	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K12_RS19410	COG2989	Protein conserved in bacteria
I6K12_RS19415	COG3108	Peptidase M15
I6K12_RS19420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K12_RS19425	COG1448	Aminotransferase
I6K12_RS19445	COG0308	aminopeptidase N
I6K12_RS19450	COG1116	anion transmembrane transporter activity
I6K12_RS19455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K12_RS19465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K12_RS19470	COG0431	NADPH-dependent FMN reductase
I6K12_RS19475	COG3539	Fimbrial protein
I6K12_RS19480	COG3121	Chaperone
I6K12_RS19485	COG3188	usher protein
I6K12_RS19490	COG3539	Fimbrial protein
I6K12_RS19495	COG3539	Fimbrial protein
I6K12_RS19500	COG3539	Fimbrial protein
I6K12_RS19505	COG3121	Chaperone
I6K12_RS19520	COG3217	Mosc domain protein beta barrel domain protein
I6K12_RS19520	COG0633	Ferredoxin
I6K12_RS19530	COG0488	(ABC) transporter
I6K12_RS19535	COG2995	paraquat-inducible protein a
I6K12_RS19540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K12_RS19540	COG3008	intermembrane lipid transfer
I6K12_RS19545	COG3009	Protein conserved in bacteria
I6K12_RS19550	COG3130	regulation of translation
I6K12_RS19560	COG1067	ATP-dependent peptidase activity
I6K12_RS19580	COG3070	regulator of competence-specific genes
I6K12_RS19585	COG1289	transmembrane transporter activity
I6K12_RS19590	COG3304	Inner membrane component domain
I6K12_RS19595	COG0210	DNA helicase
I6K12_RS19610	COG1832	CoA-binding protein
I6K12_RS19625	COG1254	Belongs to the acylphosphatase family
I6K12_RS19630	COG2920	part of a sulfur-relay system
I6K12_RS19635	COG0670	Belongs to the BI1 family
I6K12_RS19645	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K12_RS19650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K12_RS19655	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6K12_RS19660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K12_RS19665	COG1999	signal sequence binding
I6K12_RS19670	COG1773	rubredoxin
I6K12_RS19675	COG1271	oxidase subunit
I6K12_RS19680	COG1294	oxidase, subunit
I6K12_RS19695	COG1278	Cold shock
I6K12_RS19700	COG1278	Cold shock
I6K12_RS19720	COG0348	domain, Protein
I6K12_RS19725	COG2205	protein histidine kinase activity
I6K12_RS19725	COG0784	Response regulator, receiver
I6K12_RS19725	COG2198	Histidine kinase
I6K12_RS19730	COG1879	ABC-type sugar transport system periplasmic component
I6K12_RS19735	COG0745	RESPONSE REGULATOR receiver
I6K12_RS19740	COG3005	denitrification pathway
I6K12_RS19745	COG0243	molybdopterin cofactor binding
I6K12_RS19750	COG3381	protein complex oligomerization
I6K12_RS19790	COG3729	General stress protein
I6K12_RS19795	COG2233	PERMEase
I6K12_RS19830	COG1309	transcriptional regulator
I6K12_RS19835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K12_RS19835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K12_RS19835	COG0506	proline dehydrogenase activity
I6K12_RS19845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K12_RS19855	COG2822	iron ion transport
I6K12_RS19865	COG1702	phosphate starvation-inducible protein PhoH
I6K12_RS19870	COG3658	cytochrome
I6K12_RS19875	COG1215	transferase activity, transferring glycosyl groups
I6K12_RS19880	COG0726	polysaccharide deacetylase
I6K12_RS19880	COG1649	PFAM Uncharacterised BCR, COG1649
I6K12_RS19885	COG0457	Tetratricopeptide repeat
I6K12_RS19890	COG3706	GGDEF domain
I6K12_RS19910	COG3381	protein complex oligomerization
I6K12_RS19920	COG1462	curli production assembly transport component CsgG
I6K12_RS19935	COG2197	response regulator
I6K12_RS19960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K12_RS19965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K12_RS19980	COG2943	transferase activity, transferring hexosyl groups
I6K12_RS19985	COG5645	(Lipo)protein
I6K12_RS20000	COG1560	Kdo2-lipid A biosynthetic process
I6K12_RS20015	COG3038	cytochrome b561
I6K12_RS20050	COG2999	glutathione oxidoreductase activity
I6K12_RS20060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K12_RS20070	COG0673	inositol 2-dehydrogenase activity
I6K12_RS20075	COG0728	peptidoglycan biosynthetic process
I6K12_RS20080	COG3418	PFAM FlgN family protein
I6K12_RS20085	COG2747	anti-sigma28 factor FlgM
I6K12_RS20090	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6K12_RS20095	COG1815	bacterial-type flagellum-dependent cell motility
I6K12_RS20100	COG1558	bacterial-type flagellum-dependent cell motility
I6K12_RS20105	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6K12_RS20110	COG1749	Flagellar hook protein flgE
I6K12_RS20115	COG4787	bacterial-type flagellum-dependent cell motility
I6K12_RS20120	COG4786	Flagellar basal body rod
I6K12_RS20135	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6K12_RS20135	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K12_RS20140	COG1256	bacterial-type flagellum assembly
I6K12_RS20145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K12_RS20160	COG1530	ribonuclease E activity
I6K12_RS20165	COG0564	pseudouridine synthase activity
I6K12_RS20170	COG0424	maF-like protein
I6K12_RS20175	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K12_RS20195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K12_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS20210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K12_RS20220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K12_RS20225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K12_RS20235	COG0470	DNA polymerase III
I6K12_RS20240	COG0084	hydrolase, TatD family'
I6K12_RS20245	COG1263	PTS System
I6K12_RS20245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS20250	COG4773	Receptor
I6K12_RS20255	COG0537	adenosine 5'-monophosphoramidase activity
I6K12_RS20260	COG5633	Lipoprotein
I6K12_RS20265	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6K12_RS20285	COG1252	NADH dehydrogenase
I6K12_RS20290	COG3134	Outer membrane lipoprotein
I6K12_RS20295	COG1309	transcriptional regulator
I6K12_RS20305	COG1388	LysM domain
I6K12_RS20305	COG1376	ErfK ybiS ycfS ynhG family protein
I6K12_RS20310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K12_RS20315	COG4763	Acyl-transferase
I6K12_RS20320	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K12_RS20330	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K12_RS20340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K12_RS20345	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K12_RS20355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K12_RS20360	COG1177	transmembrane transport
I6K12_RS20365	COG0582	viral genome integration into host DNA
I6K12_RS20375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS20390	COG3646	Phage regulatory protein
I6K12_RS20405	COG1396	sequence-specific DNA binding
I6K12_RS20430	COG1846	Transcriptional regulator
I6K12_RS20485	COG1403	HNH endonuclease
I6K12_RS20490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K12_RS20535	COG3772	lysozyme
I6K12_RS20565	COG4220	transposase activity
I6K12_RS20670	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K12_RS20675	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K12_RS20680	COG0500	methyltransferase
I6K12_RS20695	COG3842	ATPase activity
I6K12_RS20705	COG2850	peptidyl-arginine hydroxylation
I6K12_RS20710	COG2205	protein histidine kinase activity
I6K12_RS20720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K12_RS20740	COG1187	pseudouridine synthase activity
I6K12_RS20755	COG0538	isocitrate dehydrogenase activity
I6K12_RS20775	COG5562	phage envelope protein
I6K12_RS20780	COG0789	Transcriptional regulator
I6K12_RS20785	COG2200	EAL domain
I6K12_RS20810	COG2200	EAL domain
I6K12_RS20860	COG2894	cell division
I6K12_RS20890	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K12_RS20905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K12_RS20910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K12_RS20915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6K12_RS20930	COG2719	SpoVR family
I6K12_RS20940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K12_RS20955	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K12_RS20965	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K12_RS20980	COG0157	Belongs to the NadC ModD family
I6K12_RS20985	COG0500	methyltransferase
I6K12_RS20990	COG1120	ATPase activity
I6K12_RS20995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K12_RS21000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K12_RS21010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K12_RS21010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K12_RS21010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K12_RS21015	COG1461	Dihydroxyacetone kinase
I6K12_RS21020	COG2376	Dihydroxyacetone kinase
I6K12_RS21025	COG3284	Transcriptional regulator
I6K12_RS21030	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS21035	COG0012	GTP binding
I6K12_RS21050	COG0659	secondary active sulfate transmembrane transporter activity
I6K12_RS21055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K12_RS21080	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K12_RS21085	COG3094	Invasion gene expression up-regulator, SirB
I6K12_RS21090	COG2912	Transglutaminase-like superfamily
I6K12_RS21115	COG0387	Pfam Sodium calcium exchanger
I6K12_RS21120	COG4572	Cation transport regulator
I6K12_RS21125	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K12_RS21130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K12_RS21135	COG4932	domain protein
I6K12_RS21140	COG2197	response regulator
I6K12_RS21145	COG3850	Histidine kinase
I6K12_RS21150	COG2223	nitrite transmembrane transporter activity
I6K12_RS21155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K12_RS21160	COG1140	nitrate reductase beta subunit
I6K12_RS21165	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K12_RS21170	COG2181	nitrate reductase activity
I6K12_RS21210	COG0788	formyltetrahydrofolate deformylase activity
I6K12_RS21220	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K12_RS21225	COG0745	RESPONSE REGULATOR receiver
I6K12_RS21230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K12_RS21240	COG1435	thymidine kinase activity
I6K12_RS21245	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS21245	COG1454	alcohol dehydrogenase
I6K12_RS21250	COG2095	MarC family integral membrane protein
I6K12_RS21260	COG4166	transmembrane transport
I6K12_RS21265	COG0601	transmembrane transport
I6K12_RS21270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K12_RS21275	COG0444	Belongs to the ABC transporter superfamily
I6K12_RS21280	COG4608	Belongs to the ABC transporter superfamily
I6K12_RS21300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K12_RS21305	COG2350	Protein conserved in bacteria
I6K12_RS21315	COG1607	acyl-coa hydrolase
I6K12_RS21335	COG3047	cAMP biosynthetic process
I6K12_RS21340	COG0582	viral genome integration into host DNA
I6K12_RS21350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS21380	COG1396	sequence-specific DNA binding
I6K12_RS21395	COG1846	Transcriptional regulator
I6K12_RS21410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K12_RS21435	COG1403	HNH endonuclease
I6K12_RS21440	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K12_RS21445	COG0484	heat shock protein binding
I6K12_RS21500	COG3772	lysozyme
I6K12_RS21520	COG4220	transposase activity
I6K12_RS21630	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K12_RS21635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K12_RS21640	COG0500	methyltransferase
I6K12_RS21660	COG3685	Protein conserved in bacteria
I6K12_RS21665	COG3685	Protein conserved in bacteria
I6K12_RS21670	COG3729	General stress protein
I6K12_RS21675	COG0159	tryptophan synthase activity
I6K12_RS21685	COG0134	indole-3-glycerol-phosphate synthase activity
I6K12_RS21685	COG0135	phosphoribosylanthranilate isomerase activity
I6K12_RS21690	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K12_RS21690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K12_RS21695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K12_RS21705	COG0613	PHP domain protein
I6K12_RS21710	COG0009	L-threonylcarbamoyladenylate synthase
I6K12_RS21715	COG4907	membrane protein (DUF2207)
I6K12_RS21720	COG1187	pseudouridine synthase activity
I6K12_RS21735	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K12_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS21745	COG0616	signal peptide processing
I6K12_RS21760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K12_RS21765	COG0583	DNA-binding transcription factor activity
I6K12_RS21785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K12_RS21795	COG0671	phosphoesterase, PA-phosphatase related
I6K12_RS21800	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K12_RS21805	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K12_RS21815	COG0023	Translation Initiation Factor
I6K12_RS21825	COG1349	DNA-binding transcription factor activity
I6K12_RS21835	COG5001	Diguanylate cyclase
I6K12_RS21850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K12_RS21850	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K12_RS21855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K12_RS21865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K12_RS21880	COG2814	Major facilitator Superfamily
I6K12_RS21885	COG4172	Belongs to the ABC transporter superfamily
I6K12_RS21890	COG4172	Belongs to the ABC transporter superfamily
I6K12_RS21895	COG4171	peptide transport system, permease
I6K12_RS21900	COG4168	peptide transport system, permease
I6K12_RS21905	COG4166	transmembrane transport
I6K12_RS21915	COG0531	amino acid
I6K12_RS21925	COG0174	glutamine synthetase
I6K12_RS21930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K12_RS21935	COG1917	Cupin 2, conserved barrel domain protein
I6K12_RS21935	COG1396	sequence-specific DNA binding
I6K12_RS21940	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS21945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K12_RS21950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K12_RS21960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K12_RS21965	COG1842	Phage shock protein A
I6K12_RS21975	COG1983	PspC domain protein
I6K12_RS21985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K12_RS21990	COG0366	Alpha amylase catalytic
I6K12_RS21995	COG1653	transport
I6K12_RS22000	COG1175	transmembrane transport
I6K12_RS22005	COG0395	ABC-type sugar transport system, permease component
I6K12_RS22010	COG1063	alcohol dehydrogenase
I6K12_RS22015	COG1082	Xylose isomerase domain protein TIM barrel
I6K12_RS22020	COG0673	inositol 2-dehydrogenase activity
I6K12_RS22025	COG1554	hydrolase, family 65, central catalytic
I6K12_RS22030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K12_RS22035	COG3842	ATPase activity
I6K12_RS22045	COG1609	Transcriptional regulator
I6K12_RS22050	COG3106	COG3106 Predicted ATPase
I6K12_RS22060	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6K12_RS22065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K12_RS22070	COG4948	Mandelate Racemase Muconate Lactonizing
I6K12_RS22075	COG2866	Carboxypeptidase
I6K12_RS22080	COG0702	epimerase
I6K12_RS22085	COG1073	alpha beta
I6K12_RS22090	COG0583	DNA-binding transcription factor activity
I6K12_RS22095	COG4166	transmembrane transport
I6K12_RS22100	COG0668	transmembrane transport
I6K12_RS22105	COG3182	Iron-regulated membrane protein
I6K12_RS22110	COG0589	response to stress
I6K12_RS22115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K12_RS22120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K12_RS22125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K12_RS22130	COG1473	amidohydrolase
I6K12_RS22135	COG1473	amidohydrolase
I6K12_RS22140	COG0583	DNA-binding transcription factor activity
I6K12_RS22145	COG2207	Transcriptional regulator
I6K12_RS22160	COG2840	Smr protein MutS2
I6K12_RS22165	COG3706	GGDEF domain
I6K12_RS22185	COG0513	Belongs to the DEAD box helicase family
I6K12_RS22195	COG0582	viral genome integration into host DNA
I6K12_RS22215	COG3723	Recombinational DNA repair protein, rece pathway
I6K12_RS22220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS22270	COG3756	Protein conserved in bacteria
I6K12_RS22275	COG1484	DNA-dependent DNA replication
I6K12_RS22280	COG1846	Transcriptional regulator
I6K12_RS22350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K12_RS22355	COG1475	DNA binding
I6K12_RS22440	COG1196	nuclear chromosome segregation
I6K12_RS22475	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K12_RS22505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K12_RS22510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K12_RS22515	COG1121	(ABC) transporter
I6K12_RS22525	COG0589	response to stress
I6K12_RS22530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K12_RS22535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K12_RS22535	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K12_RS22535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K12_RS22535	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K12_RS22540	COG3042	response to heat
I6K12_RS22545	COG3187	Heat shock protein
I6K12_RS22550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K12_RS22555	COG2911	Protein conserved in bacteria
I6K12_RS22565	COG3784	Protein of unknown function (DUF1318)
I6K12_RS22575	COG0667	Aldo Keto reductase
I6K12_RS22585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K12_RS22595	COG2267	carboxylic ester hydrolase activity
I6K12_RS22600	COG2453	phosphatase
I6K12_RS22600	COG0671	phosphoesterase, PA-phosphatase related
I6K12_RS22610	COG1643	Atp-dependent helicase
I6K12_RS22630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K12_RS22635	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS22640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K12_RS22645	COG3038	cytochrome b561
I6K12_RS22660	COG0840	transmembrane signaling receptor activity
I6K12_RS22665	COG0583	DNA-binding transcription factor activity
I6K12_RS22670	COG5383	Protein conserved in bacteria
I6K12_RS22680	COG2841	Protein conserved in bacteria
I6K12_RS22685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K12_RS22690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K12_RS22695	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K12_RS22700	COG0500	methyltransferase
I6K12_RS22715	COG3135	benzoate transporter
I6K12_RS22720	COG1396	sequence-specific DNA binding
I6K12_RS22725	COG0826	peptidase U32
I6K12_RS22735	COG1724	mRNA binding
I6K12_RS22740	COG1598	PFAM Uncharacterised protein family UPF0150
I6K12_RS22745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K12_RS22750	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K12_RS22755	COG3842	ATPase activity
I6K12_RS22760	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K12_RS22765	COG1177	transmembrane transport
I6K12_RS22790	COG3238	Protein conserved in bacteria
I6K12_RS22795	COG1247	-acetyltransferase
I6K12_RS22800	COG2130	NADP-dependent
I6K12_RS22805	COG1802	Transcriptional regulator
I6K12_RS22810	COG4772	TonB-dependent receptor
I6K12_RS22815	COG3391	amine dehydrogenase activity
I6K12_RS22820	COG1113	amino acid transport
I6K12_RS22825	COG0625	glutathione transferase activity
I6K12_RS22840	COG3209	COG3209 Rhs family protein
I6K12_RS22855	COG3706	GGDEF domain
I6K12_RS22855	COG2203	Gaf domain
I6K12_RS22855	COG4251	negative regulation of phosphorylation
I6K12_RS22855	COG5001	Diguanylate cyclase
I6K12_RS22860	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K12_RS22870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K12_RS22875	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K12_RS22880	COG0384	phenazine biosynthesis protein PhzF
I6K12_RS22885	COG2181	nitrate reductase activity
I6K12_RS22890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K12_RS22895	COG1140	nitrate reductase beta subunit
I6K12_RS22900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K12_RS22905	COG2223	nitrite transmembrane transporter activity
I6K12_RS22925	COG0697	spore germination
I6K12_RS22935	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS22940	COG2864	formate dehydrogenase
I6K12_RS22950	COG3093	addiction module antidote protein HigA
I6K12_RS22955	COG1064	alcohol dehydrogenase
I6K12_RS22975	COG1764	response to oxidative stress
I6K12_RS22980	COG4608	Belongs to the ABC transporter superfamily
I6K12_RS22985	COG0444	Belongs to the ABC transporter superfamily
I6K12_RS22990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K12_RS22995	COG0601	transmembrane transport
I6K12_RS23000	COG0747	negative chemotaxis
I6K12_RS23005	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6K12_RS23010	COG2199	diguanylate cyclase activity
I6K12_RS23010	COG2200	EAL domain
I6K12_RS23010	COG2202	Pas domain
I6K12_RS23025	COG1649	PFAM Uncharacterised BCR, COG1649
I6K12_RS23030	COG0531	amino acid
I6K12_RS23035	COG0076	glutamate decarboxylase activity
I6K12_RS23040	COG0612	Peptidase, M16
I6K12_RS23045	COG4771	TonB-dependent receptor
I6K12_RS23050	COG4178	(ABC) transporter
I6K12_RS23060	COG0641	radical SAM
I6K12_RS23065	COG3119	arylsulfatase activity
I6K12_RS23080	COG0243	molybdopterin cofactor binding
I6K12_RS23085	COG3539	Fimbrial protein
I6K12_RS23090	COG3539	Fimbrial protein
I6K12_RS23095	COG3539	Fimbrial protein
I6K12_RS23100	COG3188	usher protein
I6K12_RS23110	COG3539	Fimbrial protein
I6K12_RS23130	COG0667	Aldo Keto reductase
I6K12_RS23135	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K12_RS23175	COG1396	sequence-specific DNA binding
I6K12_RS23235	COG3781	membrane
I6K12_RS23245	COG2199	diguanylate cyclase activity
I6K12_RS23255	COG2066	Belongs to the glutaminase family
I6K12_RS23260	COG1012	belongs to the aldehyde dehydrogenase family
I6K12_RS23265	COG0583	DNA-binding transcription factor activity
I6K12_RS23285	COG1846	Transcriptional regulator
I6K12_RS23290	COG4977	sequence-specific DNA binding
I6K12_RS23300	COG2723	6-phospho-beta-galactosidase activity
I6K12_RS23310	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K12_RS23315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K12_RS23325	COG2188	Transcriptional regulator
I6K12_RS23330	COG0697	spore germination
I6K12_RS23335	COG2814	Major facilitator Superfamily
I6K12_RS23345	COG3706	GGDEF domain
I6K12_RS23350	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K12_RS23355	COG0339	signal peptide processing
I6K12_RS23360	COG4221	oxidoreductase activity
I6K12_RS23365	COG1802	Transcriptional regulator
I6K12_RS23375	COG0246	Mannitol dehydrogenase
I6K12_RS23395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K12_RS23420	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K12_RS23455	COG1196	nuclear chromosome segregation
I6K12_RS23505	COG1030	water channel activity
I6K12_RS23525	COG4220	transposase activity
I6K12_RS23535	COG5562	phage envelope protein
I6K12_RS23560	COG1278	Cold shock
I6K12_RS23570	COG3772	lysozyme
I6K12_RS23585	COG1278	Cold shock
I6K12_RS23590	COG1278	Cold shock
I6K12_RS23600	COG0484	heat shock protein binding
I6K12_RS23605	COG1403	HNH endonuclease
I6K12_RS23625	COG2026	Addiction module toxin, RelE StbE family
I6K12_RS23630	COG3077	Addiction module antitoxin, RelB DinJ family
I6K12_RS23645	COG2801	Transposase and inactivated derivatives
I6K12_RS23660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K12_RS23670	COG1846	Transcriptional regulator
I6K12_RS23685	COG1396	sequence-specific DNA binding
I6K12_RS23710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K12_RS23720	COG0582	viral genome integration into host DNA
I6K12_RS23730	COG1063	alcohol dehydrogenase
I6K12_RS23735	COG4948	Mandelate Racemase Muconate Lactonizing
I6K12_RS23750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K12_RS23765	COG0243	molybdopterin cofactor binding
I6K12_RS23770	COG0243	molybdopterin cofactor binding
I6K12_RS23775	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS23780	COG3302	dmso reductase anchor subunit
I6K12_RS23785	COG3381	protein complex oligomerization
I6K12_RS23795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K12_RS23800	COG1940	carbohydrate kinase activity
I6K12_RS23805	COG0583	DNA-binding transcription factor activity
I6K12_RS23810	COG2814	Major facilitator Superfamily
I6K12_RS23825	COG3591	Belongs to the peptidase S1B family
I6K12_RS23850	COG4626	Terminase
I6K12_RS23850	COG1802	Transcriptional regulator
I6K12_RS23970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K12_RS23975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K12_RS23985	COG0531	amino acid
I6K12_RS23995	COG3136	membrane protein required for alginate biosynthesis
I6K12_RS24000	COG0745	RESPONSE REGULATOR receiver
I6K12_RS24005	COG2205	protein histidine kinase activity
I6K12_RS24015	COG0114	fumarate hydratase activity
I6K12_RS24020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS24020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K12_RS24025	COG1482	cell wall glycoprotein biosynthetic process
I6K12_RS24030	COG5339	Protein conserved in bacteria
I6K12_RS24045	COG3250	beta-galactosidase activity
I6K12_RS24050	COG1309	transcriptional regulator
I6K12_RS24055	COG1028	Short-chain dehydrogenase reductase Sdr
I6K12_RS24060	COG1609	Transcriptional regulator
I6K12_RS24065	COG1263	PTS System
I6K12_RS24065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K12_RS24070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K12_RS24080	COG0673	inositol 2-dehydrogenase activity
I6K12_RS24120	COG4659	FMN binding
I6K12_RS24130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K12_RS24135	COG3104	oligopeptide transport
I6K12_RS24140	COG0625	glutathione transferase activity
I6K12_RS24145	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K12_RS24160	COG3895	Periplasmic Protein
I6K12_RS24170	COG3133	Outer membrane lipoprotein
I6K12_RS24185	COG1566	PFAM secretion protein HlyD family protein
I6K12_RS24190	COG1289	transmembrane transporter activity
I6K12_RS24195	COG2032	superoxide dismutase activity
I6K12_RS24200	COG4989	oxidoreductase activity
I6K12_RS24205	COG3313	Fe-S protein
I6K12_RS24210	COG1309	transcriptional regulator
I6K12_RS24215	COG1902	pentaerythritol trinitrate reductase activity
I6K12_RS24220	COG0346	lactoylglutathione lyase activity
I6K12_RS24230	COG1201	RNA secondary structure unwinding
I6K12_RS24235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K12_RS24240	COG0791	NLP P60 protein
I6K12_RS24245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K12_RS24250	COG2814	Major facilitator Superfamily
I6K12_RS24265	COG0583	DNA-binding transcription factor activity
I6K12_RS24270	COG2814	Major facilitator Superfamily
I6K12_RS24275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K12_RS24280	COG0307	riboflavin synthase, alpha
I6K12_RS24290	COG3468	outer membrane autotransporter barrel domain protein
I6K12_RS24310	COG4529	Protein conserved in bacteria
I6K12_RS24320	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6K12_RS24325	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS24335	COG2414	aldehyde ferredoxin oxidoreductase
I6K12_RS24340	COG0437	4 iron, 4 sulfur cluster binding
I6K12_RS24350	COG0469	pyruvate kinase activity
I6K12_RS24355	COG4238	major outer membrane lipoprotein
I6K12_RS24360	COG1376	ErfK ybiS ycfS ynhG family protein
I6K12_RS24375	COG0719	Fe-S assembly protein
I6K12_RS24380	COG0396	ATPase activity
I6K12_RS24385	COG0719	Fe-S assembly protein
I6K12_RS24390	COG0316	Belongs to the HesB IscA family
I6K12_RS24400	COG2050	protein possibly involved in aromatic compounds catabolism
I6K12_RS24405	COG0277	FAD linked oxidase domain protein
I6K12_RS24405	COG0247	lactate metabolic process
I6K12_RS24410	COG0628	permease
I6K12_RS24425	COG0738	Major facilitator superfamily
I6K12_RS24430	COG2271	Major facilitator Superfamily
I6K12_RS24445	COG4670	ketone body catabolic process
I6K12_RS24450	COG1960	acyl-CoA dehydrogenase activity
I6K12_RS24455	COG2207	Transcriptional regulator
I6K12_RS24455	COG1917	Cupin 2, conserved barrel domain protein
I6K12_RS24460	COG2086	electron transfer activity
I6K12_RS24465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K12_RS24470	COG0644	oxidoreductase
I6K12_RS24475	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K12_RS24480	COG0318	PFAM AMP-dependent synthetase and ligase
I6K12_RS24485	COG0574	Belongs to the PEP-utilizing enzyme family
I6K12_RS24485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K12_RS24495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K12_RS24500	COG4256	Hemin uptake protein
I6K12_RS24510	COG2200	EAL domain
I6K12_RS24515	COG0791	NLP P60 protein
I6K12_RS24525	COG0386	Belongs to the glutathione peroxidase family
I6K12_RS24585	COG3137	Salt-induced outer membrane protein
I6K12_RS24590	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K12_RS24600	COG3001	Fructosamine kinase
I6K12_RS24610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K12_RS24615	COG1988	membrane-bound metal-dependent
I6K12_RS24620	COG1823	symporter activity
I6K12_RS24660	COG1660	Displays ATPase and GTPase activities
I6K12_RS24690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K12_RS24985	COG1475	DNA binding
I6K12_RS25210	COG2805	Type II/IV secretion system protein
I6K12_RS25245	COG0741	lytic transglycosylase activity
I6K12_RS25260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K12_RS25300	COG2268	Band 7 protein
I6K12_RS25305	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K12_RS25365	COG1192	Involved in chromosome partitioning