locus-tag	class	description
I6K16_RS00005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K16_RS00010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K16_RS00015	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS00090	COG0740	serine-type endopeptidase activity
I6K16_RS00135	COG1278	Cold shock
I6K16_RS00145	COG3772	lysozyme
I6K16_RS00165	COG3064	Membrane
I6K16_RS00185	COG0484	heat shock protein binding
I6K16_RS00190	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K16_RS00195	COG1403	HNH endonuclease
I6K16_RS00225	COG1846	Transcriptional regulator
I6K16_RS00240	COG1396	sequence-specific DNA binding
I6K16_RS00265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K16_RS00275	COG0582	viral genome integration into host DNA
I6K16_RS00285	COG1063	alcohol dehydrogenase
I6K16_RS00290	COG4948	Mandelate Racemase Muconate Lactonizing
I6K16_RS00305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K16_RS00320	COG0243	molybdopterin cofactor binding
I6K16_RS00325	COG0243	molybdopterin cofactor binding
I6K16_RS00330	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS00335	COG3302	dmso reductase anchor subunit
I6K16_RS00340	COG3381	protein complex oligomerization
I6K16_RS00350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K16_RS00355	COG1940	carbohydrate kinase activity
I6K16_RS00360	COG0583	DNA-binding transcription factor activity
I6K16_RS00365	COG2814	Major facilitator Superfamily
I6K16_RS00380	COG3591	Belongs to the peptidase S1B family
I6K16_RS00395	COG0628	permease
I6K16_RS00400	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K16_RS00405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K16_RS00415	COG0531	amino acid
I6K16_RS00425	COG3136	membrane protein required for alginate biosynthesis
I6K16_RS00430	COG0745	RESPONSE REGULATOR receiver
I6K16_RS00435	COG2205	protein histidine kinase activity
I6K16_RS00445	COG0114	fumarate hydratase activity
I6K16_RS00450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K16_RS00450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K16_RS00455	COG1482	cell wall glycoprotein biosynthetic process
I6K16_RS00460	COG5339	Protein conserved in bacteria
I6K16_RS00475	COG3250	beta-galactosidase activity
I6K16_RS00480	COG1309	transcriptional regulator
I6K16_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS00490	COG1609	Transcriptional regulator
I6K16_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS00495	COG1263	PTS System
I6K16_RS00500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K16_RS00510	COG0673	inositol 2-dehydrogenase activity
I6K16_RS00550	COG4659	FMN binding
I6K16_RS00560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K16_RS00565	COG3104	oligopeptide transport
I6K16_RS00570	COG0625	glutathione transferase activity
I6K16_RS00575	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K16_RS00590	COG3895	Periplasmic Protein
I6K16_RS00600	COG3133	Outer membrane lipoprotein
I6K16_RS00615	COG1566	PFAM secretion protein HlyD family protein
I6K16_RS00620	COG1289	transmembrane transporter activity
I6K16_RS00625	COG2032	superoxide dismutase activity
I6K16_RS00630	COG4989	oxidoreductase activity
I6K16_RS00635	COG3313	Fe-S protein
I6K16_RS00640	COG1309	transcriptional regulator
I6K16_RS00645	COG1902	pentaerythritol trinitrate reductase activity
I6K16_RS00650	COG0346	lactoylglutathione lyase activity
I6K16_RS00660	COG1201	RNA secondary structure unwinding
I6K16_RS00665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K16_RS00670	COG0791	NLP P60 protein
I6K16_RS00675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K16_RS00680	COG2814	Major facilitator Superfamily
I6K16_RS00695	COG0583	DNA-binding transcription factor activity
I6K16_RS00700	COG2814	Major facilitator Superfamily
I6K16_RS00705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K16_RS00710	COG0307	riboflavin synthase, alpha
I6K16_RS00720	COG3468	outer membrane autotransporter barrel domain protein
I6K16_RS00740	COG4529	Protein conserved in bacteria
I6K16_RS00750	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6K16_RS00755	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS00765	COG2414	aldehyde ferredoxin oxidoreductase
I6K16_RS00770	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS00780	COG0469	pyruvate kinase activity
I6K16_RS00785	COG4238	major outer membrane lipoprotein
I6K16_RS00790	COG1376	ErfK ybiS ycfS ynhG family protein
I6K16_RS00805	COG0719	Fe-S assembly protein
I6K16_RS00810	COG0396	ATPase activity
I6K16_RS00815	COG0719	Fe-S assembly protein
I6K16_RS00820	COG0316	Belongs to the HesB IscA family
I6K16_RS00830	COG2050	protein possibly involved in aromatic compounds catabolism
I6K16_RS00835	COG0247	lactate metabolic process
I6K16_RS00835	COG0277	FAD linked oxidase domain protein
I6K16_RS00840	COG0628	permease
I6K16_RS00855	COG0738	Major facilitator superfamily
I6K16_RS00860	COG2271	Major facilitator Superfamily
I6K16_RS00875	COG4670	ketone body catabolic process
I6K16_RS00880	COG1960	acyl-CoA dehydrogenase activity
I6K16_RS00885	COG1917	Cupin 2, conserved barrel domain protein
I6K16_RS00885	COG2207	Transcriptional regulator
I6K16_RS00890	COG2086	electron transfer activity
I6K16_RS00895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K16_RS00900	COG0644	oxidoreductase
I6K16_RS00905	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K16_RS00910	COG0318	PFAM AMP-dependent synthetase and ligase
I6K16_RS00915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K16_RS00915	COG0574	Belongs to the PEP-utilizing enzyme family
I6K16_RS00925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K16_RS00930	COG4256	Hemin uptake protein
I6K16_RS00940	COG2200	EAL domain
I6K16_RS00945	COG0791	NLP P60 protein
I6K16_RS00955	COG0386	Belongs to the glutathione peroxidase family
I6K16_RS01015	COG3137	Salt-induced outer membrane protein
I6K16_RS01020	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K16_RS01030	COG3001	Fructosamine kinase
I6K16_RS01040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K16_RS01045	COG1988	membrane-bound metal-dependent
I6K16_RS01050	COG1823	symporter activity
I6K16_RS01060	COG0753	catalase activity
I6K16_RS01065	COG3394	polysaccharide catabolic process
I6K16_RS01070	COG1486	melibiose metabolic process
I6K16_RS01075	COG1917	Cupin 2, conserved barrel domain protein
I6K16_RS01075	COG2169	Transcriptional regulator
I6K16_RS01080	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K16_RS01085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K16_RS01090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K16_RS01095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K16_RS01105	COG0322	excinuclease ABC activity
I6K16_RS01115	COG3678	ATP-independent chaperone mediated protein folding
I6K16_RS01145	COG0708	Exodeoxyribonuclease III
I6K16_RS01150	COG0398	Pfam SNARE associated Golgi protein
I6K16_RS01160	COG0398	Pfam SNARE associated Golgi protein
I6K16_RS01165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K16_RS01170	COG4134	Bacterial extracellular solute-binding protein
I6K16_RS01175	COG4135	transport system, permease component
I6K16_RS01180	COG4136	ATPase activity
I6K16_RS01185	COG2897	thiosulfate sulfurtransferase activity
I6K16_RS01190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K16_RS01195	COG0494	nUDIX hydrolase
I6K16_RS01205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K16_RS01210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K16_RS01215	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K16_RS01220	COG0778	Nitroreductase
I6K16_RS01225	COG0616	signal peptide processing
I6K16_RS01230	COG0252	asparaginase activity
I6K16_RS01235	COG1335	isochorismatase
I6K16_RS01240	COG3139	Protein of unknown function (DUF1315)
I6K16_RS01250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K16_RS01255	COG0676	glucose-6-phosphate 1-epimerase activity
I6K16_RS01260	COG0656	L-ascorbic acid biosynthetic process
I6K16_RS01265	COG3713	MltA-interacting MipA family protein
I6K16_RS01270	COG2766	serine protein kinase
I6K16_RS01280	COG2199	diguanylate cyclase activity
I6K16_RS01285	COG2199	diguanylate cyclase activity
I6K16_RS01290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K16_RS01305	COG2207	Transcriptional regulator
I6K16_RS01310	COG2807	transmembrane transport
I6K16_RS01315	COG3189	MarR family transcriptional regulator
I6K16_RS01320	COG3042	response to heat
I6K16_RS01325	COG2203	Gaf domain
I6K16_RS01325	COG2199	diguanylate cyclase activity
I6K16_RS01340	COG2261	transglycosylase associated protein
I6K16_RS01350	COG3615	Tellurite resistance protein tehB
I6K16_RS01360	COG0583	DNA-binding transcription factor activity
I6K16_RS01365	COG0473	3-isopropylmalate dehydrogenase activity
I6K16_RS01370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K16_RS01375	COG4638	Rieske (2fe-2S)
I6K16_RS01380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K16_RS01385	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K16_RS01390	COG0318	PFAM AMP-dependent synthetase and ligase
I6K16_RS01395	COG3065	identical protein binding
I6K16_RS01400	COG1214	PFAM Peptidase M22, glycoprotease
I6K16_RS01405	COG1199	ATP-dependent helicase activity
I6K16_RS01410	COG0251	oxidation-reduction process
I6K16_RS01425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K16_RS01435	COG1760	l-serine dehydratase
I6K16_RS01440	COG2200	EAL domain
I6K16_RS01445	COG1253	flavin adenine dinucleotide binding
I6K16_RS01450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS01450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS01455	COG3715	PTS system
I6K16_RS01460	COG3716	PTS system mannose fructose sorbose family IID component
I6K16_RS01475	COG2226	methyltransferase
I6K16_RS01505	COG1414	Transcriptional regulator
I6K16_RS01510	COG2814	Major facilitator Superfamily
I6K16_RS01525	COG0793	Belongs to the peptidase S41A family
I6K16_RS01535	COG1956	GAF domain-containing protein
I6K16_RS01540	COG2995	paraquat-inducible protein a
I6K16_RS01545	COG3008	intermembrane lipid transfer
I6K16_RS01565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K16_RS01575	COG1276	copper resistance
I6K16_RS01580	COG2372	response to copper ion
I6K16_RS01590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K16_RS01595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K16_RS01600	COG1770	oligopeptidase
I6K16_RS01605	COG2979	Protein of unknown function (DUF533)
I6K16_RS01615	COG3141	response to X-ray
I6K16_RS01625	COG0800	Aldolase
I6K16_RS01630	COG0129	dihydroxy-acid dehydratase activity
I6K16_RS01635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K16_RS01640	COG1737	Transcriptional regulator
I6K16_RS01645	COG0469	pyruvate kinase activity
I6K16_RS01650	COG1560	Kdo2-lipid A biosynthetic process
I6K16_RS01655	COG0739	heme binding
I6K16_RS01660	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K16_RS01670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K16_RS01700	COG0217	transcriptional regulatory protein
I6K16_RS01705	COG0494	nUDIX hydrolase
I6K16_RS01715	COG1335	isochorismatase
I6K16_RS01720	COG1801	Protein of unknown function DUF72
I6K16_RS01725	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K16_RS01740	COG0243	molybdopterin cofactor binding
I6K16_RS01745	COG3005	denitrification pathway
I6K16_RS01755	COG3102	Protein conserved in bacteria
I6K16_RS01770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K16_RS01775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K16_RS01780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K16_RS01785	COG0745	RESPONSE REGULATOR receiver
I6K16_RS01795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6K16_RS01800	COG0840	transmembrane signaling receptor activity
I6K16_RS01805	COG0840	transmembrane signaling receptor activity
I6K16_RS01810	COG0835	chemotaxis
I6K16_RS01815	COG2198	Histidine kinase
I6K16_RS01815	COG0643	Histidine kinase
I6K16_RS01820	COG1360	Flagellar Motor Protein
I6K16_RS01825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K16_RS01840	COG0589	response to stress
I6K16_RS01850	COG1877	trehalose-phosphatase activity
I6K16_RS01855	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS01860	COG1129	ABC transporter
I6K16_RS01865	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS01870	COG1528	Iron-storage protein
I6K16_RS01890	COG1528	Iron-storage protein
I6K16_RS01900	COG0814	amino acid
I6K16_RS01905	COG3012	SEC-C Motif Domain Protein
I6K16_RS01905	COG3318	Belongs to the UPF0149 family
I6K16_RS01935	COG2197	response regulator
I6K16_RS01950	COG2197	response regulator
I6K16_RS01955	COG1126	abc transporter atp-binding protein
I6K16_RS01960	COG0765	amino acid transport
I6K16_RS01970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS01980	COG1191	sigma factor activity
I6K16_RS01985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K16_RS01990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K16_RS01995	COG1516	flagellar protein fliS
I6K16_RS02005	COG0366	Alpha amylase catalytic
I6K16_RS02015	COG2391	methyltransferase activity
I6K16_RS02020	COG0425	Belongs to the sulfur carrier protein TusA family
I6K16_RS02025	COG2135	peptidase activity
I6K16_RS02050	COG2207	Transcriptional regulator
I6K16_RS02055	COG1881	PFAM PEBP family protein
I6K16_RS02060	COG2076	Multidrug Resistance protein
I6K16_RS02070	COG1766	The M ring may be actively involved in energy transduction
I6K16_RS02075	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K16_RS02080	COG1317	bacterial-type flagellum organization
I6K16_RS02085	COG1157	protein secretion by the type III secretion system
I6K16_RS02090	COG2882	bacterial-type flagellum organization
I6K16_RS02095	COG3144	bacterial-type flagellum assembly
I6K16_RS02100	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K16_RS02105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K16_RS02110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K16_RS02115	COG3190	flagellar
I6K16_RS02120	COG1338	Plays a role in the flagellum-specific transport system
I6K16_RS02125	COG1987	bacterial-type flagellum assembly
I6K16_RS02130	COG1684	flagellar biosynthetic protein fliR
I6K16_RS02135	COG2197	response regulator
I6K16_RS02160	COG5475	Uncharacterized small protein (DUF2158)
I6K16_RS02165	COG2354	Protein conserved in bacteria
I6K16_RS02170	COG0697	spore germination
I6K16_RS02175	COG3727	T/G mismatch-specific endonuclease activity
I6K16_RS02180	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K16_RS02185	COG1418	mRNA catabolic process
I6K16_RS02195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K16_RS02205	COG2205	protein histidine kinase activity
I6K16_RS02210	COG0745	RESPONSE REGULATOR receiver
I6K16_RS02215	COG2351	hydroxyisourate hydrolase activity
I6K16_RS02230	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K16_RS02235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K16_RS02240	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS02330	COG4695	Portal protein
I6K16_RS02370	COG3772	lysozyme
I6K16_RS02410	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K16_RS02415	COG1403	HNH endonuclease
I6K16_RS02435	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K16_RS02445	COG1846	Transcriptional regulator
I6K16_RS02495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K16_RS02525	COG0582	viral genome integration into host DNA
I6K16_RS02530	COG1169	isochorismate synthase
I6K16_RS02535	COG2814	Major facilitator Superfamily
I6K16_RS02540	COG1132	(ABC) transporter
I6K16_RS02555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K16_RS02555	COG3433	isochorismatase activity
I6K16_RS02555	COG2226	methyltransferase
I6K16_RS02575	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K16_RS02580	COG4771	TonB-dependent receptor
I6K16_RS02585	COG1388	LysM domain
I6K16_RS02585	COG2373	Large extracellular alpha-helical protein
I6K16_RS02585	COG4932	domain protein
I6K16_RS02600	COG0477	Major facilitator Superfamily
I6K16_RS02605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K16_RS02610	COG0217	transcriptional regulatory protein
I6K16_RS02620	COG0534	Mate efflux family protein
I6K16_RS02630	COG0583	DNA-binding transcription factor activity
I6K16_RS02635	COG0583	DNA-binding transcription factor activity
I6K16_RS02645	COG1376	ErfK ybiS ycfS ynhG family protein
I6K16_RS02660	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6K16_RS02690	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K16_RS02785	COG2003	Belongs to the UPF0758 family
I6K16_RS02820	COG4917	ethanolamine utilization protein
I6K16_RS02830	COG1289	transmembrane transporter activity
I6K16_RS02840	COG1686	Belongs to the peptidase S11 family
I6K16_RS02845	COG2925	Exonuclease
I6K16_RS02850	COG0425	Belongs to the sulfur carrier protein TusA family
I6K16_RS02855	COG2391	methyltransferase activity
I6K16_RS02860	COG0531	amino acid
I6K16_RS02870	COG0583	DNA-binding transcription factor activity
I6K16_RS02875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K16_RS02890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K16_RS02900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K16_RS02900	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K16_RS02905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K16_RS02930	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6K16_RS02935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K16_RS02955	COG2244	polysaccharide biosynthetic process
I6K16_RS02985	COG2089	acid synthase
I6K16_RS03000	COG1216	Glycosyl transferase, family 2
I6K16_RS03000	COG0463	Glycosyl transferase, family 2
I6K16_RS03005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K16_RS03010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K16_RS03020	COG0438	transferase activity, transferring glycosyl groups
I6K16_RS03025	COG2327	Polysaccharide pyruvyl transferase
I6K16_RS03030	COG2244	polysaccharide biosynthetic process
I6K16_RS03035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K16_RS03040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K16_RS03045	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6K16_RS03045	COG0662	Cupin 2, conserved barrel domain protein
I6K16_RS03050	COG0297	glycogen (starch) synthase activity
I6K16_RS03055	COG1051	belongs to the nudix hydrolase family
I6K16_RS03060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K16_RS03065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6K16_RS03070	COG0110	maltose O-acetyltransferase activity
I6K16_RS03075	COG1216	Glycosyl transferase, family 2
I6K16_RS03085	COG0438	transferase activity, transferring glycosyl groups
I6K16_RS03090	COG1045	serine acetyltransferase
I6K16_RS03095	COG0463	Glycosyl transferase, family 2
I6K16_RS03100	COG0489	protein tyrosine kinase activity
I6K16_RS03100	COG3206	protein involved in exopolysaccharide biosynthesis
I6K16_RS03105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K16_RS03110	COG1596	polysaccharide export
I6K16_RS03115	COG1253	flavin adenine dinucleotide binding
I6K16_RS03120	COG2982	Protein involved in outer membrane biogenesis
I6K16_RS03130	COG0572	uridine kinase
I6K16_RS03135	COG5001	Diguanylate cyclase
I6K16_RS03135	COG5002	protein histidine kinase activity
I6K16_RS03135	COG3447	MASE1 domain protein
I6K16_RS03140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K16_RS03145	COG0443	Heat shock 70 kDa protein
I6K16_RS03150	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6K16_RS03155	COG0631	protein serine/threonine phosphatase activity
I6K16_RS03160	COG4245	von Willebrand factor, type A
I6K16_RS03205	COG2205	protein histidine kinase activity
I6K16_RS03210	COG0745	RESPONSE REGULATOR receiver
I6K16_RS03220	COG0826	peptidase U32
I6K16_RS03245	COG4584	PFAM Integrase catalytic
I6K16_RS03250	COG1484	DNA-dependent DNA replication
I6K16_RS03295	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS03295	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS03385	COG4695	Portal protein
I6K16_RS03455	COG4974	Belongs to the 'phage' integrase family
I6K16_RS03475	COG1063	alcohol dehydrogenase
I6K16_RS03480	COG3775	system Galactitol-specific IIC component
I6K16_RS03485	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K16_RS03490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS03505	COG1830	Aldolase
I6K16_RS03510	COG2211	Major facilitator Superfamily
I6K16_RS03515	COG1397	ADP-ribosylglycohydrolase
I6K16_RS03520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS03525	COG2188	Transcriptional regulator
I6K16_RS03530	COG3757	hydrolase, family 25
I6K16_RS03535	COG0351	phosphomethylpyrimidine kinase
I6K16_RS03555	COG5455	response to cobalt ion
I6K16_RS03560	COG3539	Fimbrial protein
I6K16_RS03565	COG3188	usher protein
I6K16_RS03570	COG3121	Chaperone
I6K16_RS03575	COG3539	Fimbrial protein
I6K16_RS03585	COG0489	protein tyrosine kinase activity
I6K16_RS03595	COG3831	ATPase activity
I6K16_RS03600	COG3831	ATPase activity
I6K16_RS03610	COG0714	Associated with various cellular activities
I6K16_RS03615	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K16_RS03620	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K16_RS03625	COG4715	Zinc finger, swim domain protein
I6K16_RS03630	COG4808	Protein conserved in bacteria
I6K16_RS03635	COG4807	Protein conserved in bacteria
I6K16_RS03640	COG3279	Response regulator of the LytR AlgR family
I6K16_RS03645	COG3275	phosphorelay sensor kinase activity
I6K16_RS03650	COG0789	Transcriptional regulator
I6K16_RS03660	COG1174	glycine betaine transport
I6K16_RS03665	COG1125	glycine betaine transport
I6K16_RS03670	COG1174	glycine betaine transport
I6K16_RS03675	COG1732	Glycine betaine
I6K16_RS03680	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K16_RS03685	COG0277	FAD linked oxidase domain protein
I6K16_RS03690	COG1686	Belongs to the peptidase S11 family
I6K16_RS03700	COG0586	Pfam SNARE associated Golgi protein
I6K16_RS03705	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS03720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K16_RS03730	COG1346	cytolysis
I6K16_RS03740	COG2949	membrane
I6K16_RS03750	COG0493	'glutamate synthase
I6K16_RS03755	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K16_RS03755	COG0167	dihydroorotate dehydrogenase activity
I6K16_RS03760	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS03765	COG1129	ABC transporter
I6K16_RS03770	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS03775	COG1609	Transcriptional regulator
I6K16_RS03780	COG2311	Membrane
I6K16_RS03790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6K16_RS03795	COG4771	TonB-dependent receptor
I6K16_RS03800	COG4771	TonB-dependent receptor
I6K16_RS03805	COG0833	amino acid
I6K16_RS03810	COG0583	DNA-binding transcription factor activity
I6K16_RS03815	COG2855	membrane
I6K16_RS03825	COG1522	sequence-specific DNA binding
I6K16_RS03825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS03830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K16_RS03840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K16_RS03845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K16_RS03850	COG2313	pseudouridylate synthase activity
I6K16_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS03860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS03860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS03860	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K16_RS03865	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K16_RS03870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS03870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS03875	COG2814	Major facilitator Superfamily
I6K16_RS03890	COG0246	Mannitol dehydrogenase
I6K16_RS03895	COG0523	cobalamin synthesis protein
I6K16_RS03900	COG0671	phosphoesterase, PA-phosphatase related
I6K16_RS03905	COG0791	NLP P60 protein
I6K16_RS03910	COG2200	EAL domain
I6K16_RS03915	COG4166	transmembrane transport
I6K16_RS03920	COG4174	ABC transporter (Permease)
I6K16_RS03925	COG4239	(ABC) transporter, permease
I6K16_RS03930	COG4172	Belongs to the ABC transporter superfamily
I6K16_RS03940	COG2814	Major facilitator Superfamily
I6K16_RS03945	COG1187	pseudouridine synthase activity
I6K16_RS03950	COG1061	Type III restriction enzyme res subunit
I6K16_RS03970	COG3083	sulfuric ester hydrolase activity
I6K16_RS03985	COG2197	response regulator
I6K16_RS03990	COG4235	cytochrome complex assembly
I6K16_RS03990	COG3088	subunit of a heme lyase
I6K16_RS03995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K16_RS04000	COG1138	Cytochrome C-type biogenesis protein
I6K16_RS04010	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K16_RS04015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K16_RS04020	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K16_RS04025	COG4133	protoheme IX ABC transporter activity
I6K16_RS04030	COG3005	denitrification pathway
I6K16_RS04035	COG3043	anaerobic respiration
I6K16_RS04040	COG0348	domain, Protein
I6K16_RS04045	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS04055	COG3062	negative regulation of establishment of protein localization
I6K16_RS04060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS04060	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS04075	COG4615	Cyclic peptide transporter
I6K16_RS04080	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K16_RS04085	COG2169	Transcriptional regulator
I6K16_RS04085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K16_RS04090	COG1477	protein flavinylation
I6K16_RS04095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K16_RS04100	COG2198	Histidine kinase
I6K16_RS04100	COG0642	Histidine kinase
I6K16_RS04105	COG2197	response regulator
I6K16_RS04110	COG0784	Response regulator, receiver
I6K16_RS04110	COG2205	protein histidine kinase activity
I6K16_RS04115	COG3852	Histidine kinase
I6K16_RS04120	COG2204	response regulator
I6K16_RS04125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K16_RS04130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K16_RS04135	COG2031	fatty acid transporter
I6K16_RS04140	COG0183	Belongs to the thiolase family
I6K16_RS04145	COG4676	Protein conserved in bacteria
I6K16_RS04150	COG5445	Predicted secreted protein (DUF2300)
I6K16_RS04155	COG2373	Large extracellular alpha-helical protein
I6K16_RS04160	COG3234	Protein of unknown function (DUF1175)
I6K16_RS04165	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6K16_RS04170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K16_RS04180	COG3468	outer membrane autotransporter barrel domain protein
I6K16_RS04185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K16_RS04190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K16_RS04195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K16_RS04200	COG3642	lipopolysaccharide core region biosynthetic process
I6K16_RS04205	COG0584	glycerophosphoryl diester phosphodiesterase
I6K16_RS04210	COG2271	Major facilitator Superfamily
I6K16_RS04215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K16_RS04225	COG0247	lactate metabolic process
I6K16_RS04230	COG5464	transposase or invertase
I6K16_RS04245	COG2271	Major facilitator Superfamily
I6K16_RS04295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6K16_RS04315	COG0318	PFAM AMP-dependent synthetase and ligase
I6K16_RS04320	COG1441	menaquinone biosynthetic process
I6K16_RS04325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K16_RS04340	COG1169	isochorismate synthase
I6K16_RS04345	COG4575	ribosome binding
I6K16_RS04350	COG2153	protein acetylation
I6K16_RS04365	COG2234	aminopeptidase activity
I6K16_RS04380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K16_RS04385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K16_RS04395	COG0839	Belongs to the complex I subunit 6 family
I6K16_RS04410	COG1034	ATP synthesis coupled electron transport
I6K16_RS04415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K16_RS04420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K16_RS04440	COG0583	DNA-binding transcription factor activity
I6K16_RS04445	COG0436	Aminotransferase
I6K16_RS04455	COG0471	metal ion transport
I6K16_RS04455	COG0490	domain, Protein
I6K16_RS04460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K16_RS04475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K16_RS04480	COG0857	belongs to the CobB CobQ family
I6K16_RS04480	COG0280	phosphate acetyltransferase
I6K16_RS04485	COG1288	antiporter activity
I6K16_RS04490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K16_RS04495	COG0622	Phosphoesterase
I6K16_RS04500	COG0625	glutathione transferase activity
I6K16_RS04505	COG0625	glutathione transferase activity
I6K16_RS04510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K16_RS04515	COG1090	epimerase
I6K16_RS04520	COG5464	transposase or invertase
I6K16_RS04525	COG4598	ABC transporter
I6K16_RS04530	COG4160	amino acid transport
I6K16_RS04535	COG4215	(ABC) transporter
I6K16_RS04540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS04550	COG0163	prenyltransferase activity
I6K16_RS04555	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K16_RS04560	COG1286	toxin biosynthetic process
I6K16_RS04565	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K16_RS04570	COG0285	dihydrofolate synthase activity
I6K16_RS04580	COG0586	Pfam SNARE associated Golgi protein
I6K16_RS04590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K16_RS04605	COG2814	Major facilitator Superfamily
I6K16_RS04610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K16_RS04625	COG3101	peptidyl-lysine hydroxylation
I6K16_RS04630	COG0730	response to heat
I6K16_RS04660	COG3539	Fimbrial protein
I6K16_RS04665	COG3539	Fimbrial protein
I6K16_RS04670	COG3539	Fimbrial protein
I6K16_RS04675	COG3121	Chaperone
I6K16_RS04680	COG3188	usher protein
I6K16_RS04685	COG3539	Fimbrial protein
I6K16_RS04690	COG2062	phosphohistidine phosphatase, SixA
I6K16_RS04705	COG3691	Protein conserved in bacteria
I6K16_RS04710	COG2067	long-chain fatty acid transport protein
I6K16_RS04715	COG2853	Lipoprotein
I6K16_RS04720	COG2116	formate transmembrane transporter activity
I6K16_RS04765	COG0477	Major facilitator Superfamily
I6K16_RS04770	COG1566	PFAM secretion protein HlyD family protein
I6K16_RS04775	COG2197	response regulator
I6K16_RS04780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS04780	COG0784	Response regulator, receiver
I6K16_RS04780	COG2205	protein histidine kinase activity
I6K16_RS04780	COG2198	Histidine kinase
I6K16_RS04785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K16_RS04790	COG0679	Auxin Efflux Carrier
I6K16_RS04795	COG0028	Belongs to the TPP enzyme family
I6K16_RS04820	COG1560	Kdo2-lipid A biosynthetic process
I6K16_RS04830	COG0436	Aminotransferase
I6K16_RS04835	COG3275	phosphorelay sensor kinase activity
I6K16_RS04840	COG3279	Response regulator of the LytR AlgR family
I6K16_RS04845	COG2207	Transcriptional regulator
I6K16_RS04850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K16_RS04850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS04850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS04855	COG1363	Peptidase, m42
I6K16_RS04860	COG0006	proline dipeptidase activity
I6K16_RS04865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS04870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS04895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K16_RS04900	COG2199	diguanylate cyclase activity
I6K16_RS04900	COG2200	EAL domain
I6K16_RS04915	COG3415	Transposase
I6K16_RS04920	COG3415	Transposase
I6K16_RS04925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K16_RS04955	COG0583	DNA-binding transcription factor activity
I6K16_RS04965	COG2211	Major facilitator Superfamily
I6K16_RS04970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K16_RS04980	COG0583	DNA-binding transcription factor activity
I6K16_RS04985	COG0385	Bile acid
I6K16_RS04990	COG3530	Putative quorum-sensing-regulated virulence factor
I6K16_RS05010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K16_RS05015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS05020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K16_RS05025	COG2190	(PTS) system
I6K16_RS05040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K16_RS05045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K16_RS05050	COG4208	sulfate ABC transporter
I6K16_RS05055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K16_RS05060	COG4150	thiosulfate binding
I6K16_RS05065	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS05080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS05080	COG1263	PTS System
I6K16_RS05085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K16_RS05090	COG2837	iron assimilation
I6K16_RS05110	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K16_RS05120	COG2207	Transcriptional regulator
I6K16_RS05125	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K16_RS05130	COG4816	utilization protein
I6K16_RS05140	COG4303	Ethanolamine ammonia lyase large subunit
I6K16_RS05145	COG4819	ethanolamine utilization protein
I6K16_RS05150	COG3192	ethanolamine utilization protein
I6K16_RS05155	COG1454	alcohol dehydrogenase
I6K16_RS05160	COG4820	ethanolamine utilization protein (EutJ)
I6K16_RS05165	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS05170	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K16_RS05175	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K16_RS05180	COG0280	phosphate acetyltransferase
I6K16_RS05185	COG4812	Cobalamin adenosyltransferase
I6K16_RS05190	COG4766	ethanolamine catabolic process
I6K16_RS05195	COG4917	ethanolamine utilization protein
I6K16_RS05200	COG4810	utilization protein
I6K16_RS05205	COG0281	malic enzyme
I6K16_RS05205	COG0280	phosphate acetyltransferase
I6K16_RS05210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K16_RS05215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K16_RS05220	COG5342	invasion associated locus B
I6K16_RS05230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS05230	COG0493	'glutamate synthase
I6K16_RS05235	COG3850	Histidine kinase
I6K16_RS05240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K16_RS05250	COG1393	Belongs to the ArsC family
I6K16_RS05265	COG0400	carboxylic ester hydrolase activity
I6K16_RS05275	COG2321	neutral zinc metallopeptidase
I6K16_RS05295	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K16_RS05305	COG2716	regulation of RNA biosynthetic process
I6K16_RS05310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K16_RS05315	COG0628	permease
I6K16_RS05320	COG4783	chaperone-mediated protein folding
I6K16_RS05325	COG1393	Belongs to the ArsC family
I6K16_RS05335	COG2233	PERMEase
I6K16_RS05350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K16_RS05355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6K16_RS05360	COG0248	Ppx GppA phosphatase
I6K16_RS05365	COG2200	EAL domain
I6K16_RS05380	COG3133	Outer membrane lipoprotein
I6K16_RS05395	COG0516	GMP reductase activity
I6K16_RS05395	COG0517	IMP dehydrogenase activity
I6K16_RS05420	COG1645	bacterial-type flagellum-dependent swarming motility
I6K16_RS05435	COG2976	Protein conserved in bacteria
I6K16_RS05465	COG4953	penicillin-binding protein 1C
I6K16_RS05470	COG2373	Large extracellular alpha-helical protein
I6K16_RS05475	COG2897	thiosulfate sulfurtransferase activity
I6K16_RS05490	COG2975	iron-sulfur cluster assembly
I6K16_RS05495	COG0633	Ferredoxin
I6K16_RS05515	COG0822	iron-sulfur transferase activity
I6K16_RS05535	COG0483	inositol monophosphate 1-phosphatase activity
I6K16_RS05540	COG1073	alpha beta
I6K16_RS05545	COG3711	transcriptional antiterminator
I6K16_RS05550	COG2814	Major facilitator Superfamily
I6K16_RS05555	COG0583	DNA-binding transcription factor activity
I6K16_RS05560	COG4638	Rieske (2fe-2S)
I6K16_RS05585	COG2259	Doxx family
I6K16_RS05590	COG2017	converts alpha-aldose to the beta-anomer
I6K16_RS05595	COG1063	alcohol dehydrogenase
I6K16_RS05600	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS05605	COG1129	ABC transporter
I6K16_RS05615	COG0457	Tetratricopeptide repeat
I6K16_RS05620	COG1940	carbohydrate kinase activity
I6K16_RS05630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K16_RS05630	COG1017	nitric oxide dioxygenase activity
I6K16_RS05635	COG0347	Belongs to the P(II) protein family
I6K16_RS05640	COG2204	response regulator
I6K16_RS05645	COG3170	Tfp pilus assembly protein FimV
I6K16_RS05650	COG2205	protein histidine kinase activity
I6K16_RS05655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K16_RS05655	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K16_RS05670	COG0560	Phosphoserine phosphatase
I6K16_RS05675	COG1737	Transcriptional regulator
I6K16_RS05680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS05695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K16_RS05715	COG0681	Belongs to the peptidase S26 family
I6K16_RS05725	COG3086	response to oxidative stress
I6K16_RS05730	COG3026	antisigma factor binding
I6K16_RS05735	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K16_RS05740	COG1595	DNA-templated transcription, initiation
I6K16_RS05750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K16_RS05760	COG0513	Belongs to the DEAD box helicase family
I6K16_RS05765	COG0583	DNA-binding transcription factor activity
I6K16_RS05785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K16_RS05790	COG3118	belongs to the thioredoxin family
I6K16_RS05795	COG3148	PFAM DTW domain containing protein
I6K16_RS05800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K16_RS05800	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K16_RS05800	COG1042	CoA-binding domain protein
I6K16_RS05805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K16_RS05810	COG5544	Lipoprotein
I6K16_RS05815	COG0477	Major facilitator Superfamily
I6K16_RS05840	COG0542	response to heat
I6K16_RS05850	COG0564	pseudouridine synthase activity
I6K16_RS05855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K16_RS05865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K16_RS05875	COG0077	Prephenate dehydratase
I6K16_RS05875	COG1605	Chorismate mutase
I6K16_RS05880	COG0287	Prephenate dehydrogenase
I6K16_RS05880	COG1605	Chorismate mutase
I6K16_RS05885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K16_RS05900	COG2199	diguanylate cyclase activity
I6K16_RS05905	COG2885	chlorophyll binding
I6K16_RS05930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K16_RS05935	COG4137	Cytochrome C assembly protein
I6K16_RS05940	COG4536	flavin adenine dinucleotide binding
I6K16_RS05955	COG0497	DNA recombination
I6K16_RS05960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K16_RS05970	COG2867	negative regulation of translational initiation
I6K16_RS05990	COG0579	oxidoreductase
I6K16_RS05995	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS06000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K16_RS06005	COG1113	amino acid transport
I6K16_RS06010	COG1802	Transcriptional regulator
I6K16_RS06015	COG1652	LysM domain
I6K16_RS06020	COG0401	homolog of Blt101
I6K16_RS06025	COG0640	Transcriptional regulator
I6K16_RS06030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K16_RS06035	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K16_RS06050	COG4575	ribosome binding
I6K16_RS06055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K16_RS06065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K16_RS06070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K16_RS06075	COG4175	Glycine betaine
I6K16_RS06080	COG4176	ABC-type proline glycine betaine transport system permease component
I6K16_RS06085	COG2113	Glycine betaine
I6K16_RS06090	COG2814	Major facilitator Superfamily
I6K16_RS06095	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K16_RS06105	COG1846	Transcriptional regulator
I6K16_RS06110	COG1566	PFAM secretion protein HlyD family protein
I6K16_RS06115	COG2814	Major facilitator Superfamily
I6K16_RS06130	COG1238	metal cluster binding
I6K16_RS06135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K16_RS06165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K16_RS06185	COG1546	Belongs to the CinA family
I6K16_RS06190	COG2951	lytic endotransglycosylase activity
I6K16_RS06195	COG3730	PTS system glucitol sorbitol-specific
I6K16_RS06200	COG3732	PTS system glucitol sorbitol-specific
I6K16_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS06215	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS06220	COG1349	DNA-binding transcription factor activity
I6K16_RS06225	COG0517	IMP dehydrogenase activity
I6K16_RS06225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K16_RS06245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K16_RS06250	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS06255	COG1609	Transcriptional regulator
I6K16_RS06260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS06260	COG1263	PTS System
I6K16_RS06265	COG2723	6-phospho-beta-galactosidase activity
I6K16_RS06270	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K16_RS06280	COG3260	NADH ubiquinone oxidoreductase 20
I6K16_RS06285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K16_RS06290	COG3261	NADH dehydrogenase
I6K16_RS06290	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K16_RS06295	COG0650	Formate hydrogenlyase subunit 4
I6K16_RS06300	COG0651	ATP synthesis coupled electron transport
I6K16_RS06305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS06315	COG0375	protein maturation
I6K16_RS06320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K16_RS06325	COG0298	carbon dioxide binding
I6K16_RS06330	COG0409	Hydrogenase expression formation protein
I6K16_RS06335	COG0309	Hydrogenase expression formation protein (HypE)
I6K16_RS06340	COG3604	Transcriptional regulator
I6K16_RS06365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K16_RS06370	COG1349	DNA-binding transcription factor activity
I6K16_RS06375	COG2084	Dehydrogenase
I6K16_RS06380	COG3395	kinase activity
I6K16_RS06385	COG0235	Class ii aldolase
I6K16_RS06390	COG3622	Belongs to the hyi family
I6K16_RS06395	COG2610	gluconate transmembrane transporter activity
I6K16_RS06405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K16_RS06410	COG0163	prenyltransferase activity
I6K16_RS06420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K16_RS06425	COG4942	peptidase
I6K16_RS06425	COG1388	LysM domain
I6K16_RS06440	COG0585	pseudouridine synthase activity
I6K16_RS06480	COG2234	aminopeptidase activity
I6K16_RS06485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K16_RS06490	COG1518	maintenance of DNA repeat elements
I6K16_RS06505	COG1857	crispr-associated protein
I6K16_RS06520	COG1203	CRISPR-associated helicase, Cas3
I6K16_RS06545	COG0720	synthase
I6K16_RS06550	COG0644	oxidoreductase
I6K16_RS06555	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K16_RS06560	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6K16_RS06565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K16_RS06570	COG2086	electron transfer activity
I6K16_RS06575	COG0477	Major facilitator Superfamily
I6K16_RS06580	COG0277	FAD linked oxidase domain protein
I6K16_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS06590	COG2223	nitrite transmembrane transporter activity
I6K16_RS06595	COG1070	Carbohydrate kinase
I6K16_RS06600	COG0602	queuosine metabolic process
I6K16_RS06620	COG3956	TIGRFAM MazG family protein
I6K16_RS06625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K16_RS06635	COG3437	response regulator, receiver
I6K16_RS06635	COG3850	Histidine kinase
I6K16_RS06635	COG4999	Histidine kinase
I6K16_RS06635	COG2205	protein histidine kinase activity
I6K16_RS06640	COG4948	Mandelate Racemase Muconate Lactonizing
I6K16_RS06645	COG4948	Mandelate Racemase Muconate Lactonizing
I6K16_RS06650	COG2271	Major facilitator Superfamily
I6K16_RS06655	COG0716	FMN binding
I6K16_RS06660	COG0564	pseudouridine synthase activity
I6K16_RS06665	COG3098	single-species biofilm formation
I6K16_RS06680	COG1611	Belongs to the LOG family
I6K16_RS06685	COG0814	amino acid
I6K16_RS06690	COG1760	l-serine dehydratase
I6K16_RS06700	COG1454	alcohol dehydrogenase
I6K16_RS06705	COG0235	Class ii aldolase
I6K16_RS06710	COG0738	Major facilitator superfamily
I6K16_RS06720	COG1070	Carbohydrate kinase
I6K16_RS06730	COG1349	DNA-binding transcription factor activity
I6K16_RS06740	COG2363	Small membrane protein
I6K16_RS06745	COG0583	DNA-binding transcription factor activity
I6K16_RS06755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K16_RS06760	COG2166	iron-sulfur cluster assembly
I6K16_RS06765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K16_RS06775	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K16_RS06815	COG2885	chlorophyll binding
I6K16_RS06845	COG1484	DNA-dependent DNA replication
I6K16_RS06850	COG4584	PFAM Integrase catalytic
I6K16_RS06915	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K16_RS06920	COG1263	PTS System
I6K16_RS06920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS06925	COG3711	transcriptional antiterminator
I6K16_RS06930	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K16_RS06935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K16_RS06935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K16_RS06940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K16_RS06945	COG1074	ATP-dependent DNA helicase activity
I6K16_RS06955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K16_RS06960	COG4967	type IV pilus modification protein PilV
I6K16_RS06970	COG4795	General secretion pathway protein
I6K16_RS06975	COG2165	general secretion pathway protein
I6K16_RS06990	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6K16_RS07005	COG0861	Integral membrane protein TerC family
I6K16_RS07015	COG0667	Aldo Keto reductase
I6K16_RS07030	COG1609	Transcriptional regulator
I6K16_RS07040	COG0583	DNA-binding transcription factor activity
I6K16_RS07045	COG1794	racemase activity, acting on amino acids and derivatives
I6K16_RS07050	COG2814	Major facilitator Superfamily
I6K16_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS07065	COG0183	Belongs to the thiolase family
I6K16_RS07070	COG0814	amino acid
I6K16_RS07165	COG4942	peptidase
I6K16_RS07170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K16_RS07175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K16_RS07180	COG2080	2 iron, 2 sulfur cluster binding
I6K16_RS07185	COG3829	transcription factor binding
I6K16_RS07190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K16_RS07195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K16_RS07200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K16_RS07210	COG0549	Belongs to the carbamate kinase family
I6K16_RS07215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K16_RS07215	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K16_RS07220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K16_RS07225	COG2068	MobA-Related Protein
I6K16_RS07230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS07230	COG0493	'glutamate synthase
I6K16_RS07235	COG0402	S-adenosylhomocysteine deaminase activity
I6K16_RS07240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K16_RS07245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K16_RS07245	COG2080	2 iron, 2 sulfur cluster binding
I6K16_RS07250	COG2233	PERMEase
I6K16_RS07255	COG0402	S-adenosylhomocysteine deaminase activity
I6K16_RS07260	COG2252	PERMEase
I6K16_RS07265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS07270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS07270	COG0493	'glutamate synthase
I6K16_RS07275	COG2233	PERMEase
I6K16_RS07290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K16_RS07300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K16_RS07305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K16_RS07310	COG4974	Belongs to the 'phage' integrase family
I6K16_RS07315	COG0716	FMN binding
I6K16_RS07325	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K16_RS07335	COG1272	protein, Hemolysin III
I6K16_RS07345	COG2723	6-phospho-beta-galactosidase activity
I6K16_RS07370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K16_RS07375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K16_RS07380	COG0006	proline dipeptidase activity
I6K16_RS07400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K16_RS07410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K16_RS07430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K16_RS07430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K16_RS07435	COG1703	isobutyryl-CoA mutase activity
I6K16_RS07440	COG1024	Enoyl-CoA hydratase
I6K16_RS07445	COG0427	acetyl-CoA hydrolase
I6K16_RS07450	COG0583	DNA-binding transcription factor activity
I6K16_RS07455	COG2968	Membrane
I6K16_RS07460	COG1279	arginine transmembrane transporter activity
I6K16_RS07465	COG0668	transmembrane transport
I6K16_RS07470	COG0191	fructose-bisphosphate aldolase activity
I6K16_RS07485	COG1072	(Pantothenic acid kinase))
I6K16_RS07495	COG1494	fructose-1,6-bisphosphatase
I6K16_RS07500	COG1063	alcohol dehydrogenase
I6K16_RS07505	COG2213	PTS system mannitol-specific
I6K16_RS07510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS07515	COG0330	HflC and HflK could
I6K16_RS07520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K16_RS07525	COG0501	Belongs to the peptidase M48B family
I6K16_RS07540	COG1166	arginine decarboxylase activity
I6K16_RS07560	COG2814	Major facilitator Superfamily
I6K16_RS07570	COG2356	endonuclease I
I6K16_RS07575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K16_RS07580	COG0189	ligase activity
I6K16_RS07595	COG2805	Type II/IV secretion system protein
I6K16_RS07600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K16_RS07605	COG0762	integral membrane protein
I6K16_RS07620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K16_RS07625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K16_RS07630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K16_RS07645	COG0252	asparaginase activity
I6K16_RS07655	COG3171	Protein conserved in bacteria
I6K16_RS07665	COG1194	a g-specific adenine glycosylase
I6K16_RS07680	COG2211	Major facilitator Superfamily
I6K16_RS07685	COG1982	Orn Lys Arg decarboxylase major
I6K16_RS07690	COG1811	Na channel or pump
I6K16_RS07700	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K16_RS07730	COG2165	general secretion pathway protein
I6K16_RS07735	COG1459	type II secretion system
I6K16_RS07740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K16_RS07760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K16_RS07765	COG3064	Membrane
I6K16_RS07770	COG1620	l-lactate permease
I6K16_RS07775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K16_RS07780	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K16_RS07785	COG0247	lactate metabolic process
I6K16_RS07790	COG0277	FAD linked oxidase domain protein
I6K16_RS07795	COG0277	FAD linked oxidase domain protein
I6K16_RS07800	COG2186	Transcriptional regulator
I6K16_RS07805	COG0456	acetyltransferase
I6K16_RS07820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K16_RS07825	COG0156	8-amino-7-oxononanoate synthase activity
I6K16_RS07835	COG0795	lipopolysaccharide-transporting ATPase activity
I6K16_RS07840	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K16_RS07850	COG2244	polysaccharide biosynthetic process
I6K16_RS07855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K16_RS07860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K16_RS07865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K16_RS07870	COG0306	phosphate transporter
I6K16_RS07875	COG0754	glutathionylspermidine amidase activity
I6K16_RS07880	COG0625	glutathione transferase activity
I6K16_RS07885	COG0298	carbon dioxide binding
I6K16_RS07890	COG0375	protein maturation
I6K16_RS07895	COG1773	rubredoxin
I6K16_RS07900	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K16_RS07905	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K16_RS07910	COG5557	Pfam Polysulphide reductase, NrfD
I6K16_RS07915	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS07920	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K16_RS07935	COG0667	Aldo Keto reductase
I6K16_RS07945	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS07950	COG0848	biopolymer transport protein
I6K16_RS07955	COG0811	peptide transport
I6K16_RS07960	COG0626	cystathionine gamma-synthase activity
I6K16_RS07965	COG0586	Pfam SNARE associated Golgi protein
I6K16_RS07970	COG2207	Transcriptional regulator
I6K16_RS07975	COG1979	alcohol dehydrogenase
I6K16_RS07980	COG0656	L-ascorbic acid biosynthetic process
I6K16_RS07990	COG4238	major outer membrane lipoprotein
I6K16_RS07995	COG1032	radical SAM domain protein
I6K16_RS08000	COG2132	Multicopper oxidase
I6K16_RS08005	COG0204	Acyl-transferase
I6K16_RS08010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K16_RS08015	COG4166	transmembrane transport
I6K16_RS08020	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K16_RS08025	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K16_RS08030	COG0745	RESPONSE REGULATOR receiver
I6K16_RS08035	COG0642	Histidine kinase
I6K16_RS08040	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K16_RS08045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K16_RS08050	COG1737	Transcriptional regulator
I6K16_RS08060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS08065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS08070	COG1120	ATPase activity
I6K16_RS08075	COG4774	siderophore transport
I6K16_RS08080	COG2211	Major facilitator Superfamily
I6K16_RS08100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS08120	COG0187	DNA topoisomerase II activity
I6K16_RS08125	COG3150	esterase
I6K16_RS08130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K16_RS08135	COG3151	Protein conserved in bacteria
I6K16_RS08140	COG0494	nUDIX hydrolase
I6K16_RS08145	COG1538	Outer membrane efflux protein
I6K16_RS08155	COG0754	glutathionylspermidine amidase activity
I6K16_RS08165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K16_RS08175	COG3384	dioxygenase
I6K16_RS08205	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K16_RS08210	COG2268	Band 7 protein
I6K16_RS08230	COG3025	triphosphatase activity
I6K16_RS08235	COG4991	sh3 domain protein
I6K16_RS08250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K16_RS08265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K16_RS08270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K16_RS08285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K16_RS08290	COG0358	DNA primase activity
I6K16_RS08295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K16_RS08310	COG2375	cellular response to nickel ion
I6K16_RS08315	COG1695	Transcriptional regulator
I6K16_RS08320	COG0840	transmembrane signaling receptor activity
I6K16_RS08330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K16_RS08335	COG1609	Transcriptional regulator
I6K16_RS08340	COG3250	beta-galactosidase activity
I6K16_RS08345	COG2731	YhcH YjgK YiaL family protein
I6K16_RS08350	COG0531	amino acid
I6K16_RS08360	COG3408	Glycogen debranching enzyme
I6K16_RS08360	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K16_RS08365	COG1902	pentaerythritol trinitrate reductase activity
I6K16_RS08365	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K16_RS08370	COG5499	transcription regulator containing HTH domain
I6K16_RS08385	COG1451	nucleotide metabolic process
I6K16_RS08390	COG2949	membrane
I6K16_RS08395	COG0673	inositol 2-dehydrogenase activity
I6K16_RS08400	COG0861	Integral membrane protein TerC family
I6K16_RS08405	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6K16_RS08415	COG2721	sulfolactate sulfo-lyase activity
I6K16_RS08425	COG2271	Major facilitator Superfamily
I6K16_RS08430	COG2186	Transcriptional regulator
I6K16_RS08435	COG0586	Pfam SNARE associated Golgi protein
I6K16_RS08445	COG1422	Protein of unknown function (DUF1090)
I6K16_RS08450	COG4575	ribosome binding
I6K16_RS08455	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K16_RS08465	COG2259	Doxx family
I6K16_RS08470	COG0435	Glutathione S-transferase
I6K16_RS08475	COG3152	Membrane
I6K16_RS08480	COG3152	Membrane
I6K16_RS08485	COG0583	DNA-binding transcription factor activity
I6K16_RS08490	COG1741	Belongs to the pirin family
I6K16_RS08505	COG0814	amino acid
I6K16_RS08510	COG1760	l-serine dehydratase
I6K16_RS08515	COG0251	oxidation-reduction process
I6K16_RS08520	COG1882	Formate acetyltransferase
I6K16_RS08525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K16_RS08535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K16_RS08540	COG0583	DNA-binding transcription factor activity
I6K16_RS08555	COG1929	Belongs to the glycerate kinase type-1 family
I6K16_RS08560	COG2084	Dehydrogenase
I6K16_RS08570	COG2271	Major facilitator Superfamily
I6K16_RS08575	COG2721	sulfolactate sulfo-lyase activity
I6K16_RS08580	COG2002	toxin-antitoxin pair type II binding
I6K16_RS08590	COG1349	DNA-binding transcription factor activity
I6K16_RS08600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS08610	COG3716	PTS system mannose fructose sorbose family IID component
I6K16_RS08615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS08620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K16_RS08625	COG2222	sugar isomerase
I6K16_RS08635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS08640	COG3715	PTS system
I6K16_RS08645	COG3716	PTS system mannose fructose sorbose family IID component
I6K16_RS08650	COG0363	glucosamine-6-phosphate deaminase activity
I6K16_RS08655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K16_RS08675	COG2823	Periplasmic or secreted lipoprotein
I6K16_RS08680	COG0701	Predicted permease
I6K16_RS08685	COG0702	epimerase
I6K16_RS08690	COG0693	protein deglycase activity
I6K16_RS08705	COG3153	acetyltransferase
I6K16_RS08710	COG3154	lipid carrier protein
I6K16_RS08715	COG0826	peptidase U32
I6K16_RS08720	COG0826	peptidase U32
I6K16_RS08725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K16_RS08730	COG0814	amino acid
I6K16_RS08735	COG0513	Belongs to the DEAD box helicase family
I6K16_RS08775	COG0195	Participates in both transcription termination and antitermination
I6K16_RS08795	COG2194	sulfuric ester hydrolase activity
I6K16_RS08805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K16_RS08815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K16_RS08820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K16_RS08830	COG1534	Rna-binding protein
I6K16_RS08835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K16_RS08840	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K16_RS08850	COG0697	spore germination
I6K16_RS08865	COG0142	geranyltranstransferase activity
I6K16_RS08870	COG3423	Transcriptional regulator
I6K16_RS08880	COG5007	Belongs to the BolA IbaG family
I6K16_RS08885	COG3113	response to antibiotic
I6K16_RS08890	COG2854	intermembrane phospholipid transfer
I6K16_RS08895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K16_RS08900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K16_RS08905	COG1127	ABC transporter
I6K16_RS08910	COG0530	calcium, potassium:sodium antiporter activity
I6K16_RS08915	COG0517	IMP dehydrogenase activity
I6K16_RS08915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K16_RS08920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K16_RS08925	COG3117	lipopolysaccharide transmembrane transporter activity
I6K16_RS08930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K16_RS08935	COG1137	ATPase activity
I6K16_RS08940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K16_RS08945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K16_RS08960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS08965	COG0515	serine threonine protein kinase
I6K16_RS08975	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K16_RS08980	COG5002	protein histidine kinase activity
I6K16_RS08980	COG0784	Response regulator, receiver
I6K16_RS08980	COG2198	Histidine kinase
I6K16_RS08985	COG1242	4 iron, 4 sulfur cluster binding
I6K16_RS08990	COG0069	glutamate synthase activity
I6K16_RS08990	COG0067	glutamate synthase
I6K16_RS08990	COG0070	glutamate synthase
I6K16_RS08995	COG0493	'glutamate synthase
I6K16_RS09000	COG4804	nuclease activity
I6K16_RS09005	COG2731	YhcH YjgK YiaL family protein
I6K16_RS09035	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K16_RS09040	COG2969	positive regulation of protein catabolic process
I6K16_RS09045	COG0625	glutathione transferase activity
I6K16_RS09060	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K16_RS09065	COG3105	Protein conserved in bacteria
I6K16_RS09070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K16_RS09075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K16_RS09095	COG2732	(Barnase) inhibitor
I6K16_RS09115	COG0583	DNA-binding transcription factor activity
I6K16_RS09120	COG0312	modulator of DNA gyrase
I6K16_RS09125	COG3164	Protein of unknown function
I6K16_RS09130	COG1530	ribonuclease E activity
I6K16_RS09140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K16_RS09145	COG1792	Involved in formation and maintenance of cell shape
I6K16_RS09150	COG1077	Cell shape determining protein MreB Mrl
I6K16_RS09155	COG2199	diguanylate cyclase activity
I6K16_RS09155	COG2200	EAL domain
I6K16_RS09160	COG0604	alcohol dehydrogenase
I6K16_RS09170	COG0511	ligase activity, forming carbon-carbon bonds
I6K16_RS09175	COG0439	Biotin carboxylase
I6K16_RS09180	COG3924	membrane
I6K16_RS09185	COG4145	pantothenate transmembrane transporter activity
I6K16_RS09195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K16_RS09205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K16_RS09215	COG1309	transcriptional regulator
I6K16_RS09220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS09225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K16_RS09235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS09240	COG4597	amino acid ABC transporter
I6K16_RS09245	COG0765	amino acid transport
I6K16_RS09250	COG1126	abc transporter atp-binding protein
I6K16_RS09290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K16_RS09310	COG0551	DNA topoisomerase type I activity
I6K16_RS09320	COG0758	DNA mediated transformation
I6K16_RS09340	COG0569	domain protein
I6K16_RS09350	COG3036	rescue of stalled ribosome
I6K16_RS09355	COG0789	Transcriptional regulator
I6K16_RS09395	COG0201	protein transport
I6K16_RS09485	COG0089	rRNA binding
I6K16_RS09510	COG3267	Type II secretory pathway component ExeA
I6K16_RS09510	COG3409	Peptidoglycan-binding domain 1 protein
I6K16_RS09515	COG3031	protein transport across the cell outer membrane
I6K16_RS09520	COG1450	Type ii and iii secretion system protein
I6K16_RS09525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K16_RS09530	COG1459	type II secretion system
I6K16_RS09535	COG2165	general secretion pathway protein
I6K16_RS09540	COG2165	general secretion pathway protein
I6K16_RS09545	COG2165	general secretion pathway protein
I6K16_RS09550	COG4795	General secretion pathway protein
I6K16_RS09555	COG3156	type II secretion system protein K
I6K16_RS09560	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K16_RS09565	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K16_RS09570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K16_RS09575	COG2193	ferroxidase activity
I6K16_RS09580	COG2906	2 iron, 2 sulfur cluster binding
I6K16_RS09585	COG3979	chitinase
I6K16_RS09625	COG2964	Protein conserved in bacteria
I6K16_RS09630	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K16_RS09640	COG1047	Peptidyl-prolyl cis-trans
I6K16_RS09645	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K16_RS09660	COG0488	(ABC) transporter
I6K16_RS09665	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K16_RS09675	COG3954	Phosphoribulokinase
I6K16_RS09680	COG1765	OsmC-like protein
I6K16_RS09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K16_RS09690	COG1289	transmembrane transporter activity
I6K16_RS09695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K16_RS09700	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K16_RS09705	COG2184	nucleotidyltransferase activity
I6K16_RS09715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K16_RS09725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K16_RS09730	COG2146	nitrite reductase [NAD(P)H] activity
I6K16_RS09735	COG2116	formate transmembrane transporter activity
I6K16_RS09750	COG0626	cystathionine gamma-synthase activity
I6K16_RS09765	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K16_RS09770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6K16_RS09775	COG3457	Alanine racemase
I6K16_RS09785	COG2188	Transcriptional regulator
I6K16_RS09790	COG0180	Tryptophanyl-tRNA synthetase
I6K16_RS09800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K16_RS09805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K16_RS09810	COG3266	domain, Protein
I6K16_RS09825	COG4796	Type ii and iii secretion system protein
I6K16_RS09840	COG3166	PFAM Fimbrial assembly family protein
I6K16_RS09845	COG4972	Pilus assembly protein
I6K16_RS09850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K16_RS09855	COG0494	nUDIX hydrolase
I6K16_RS09865	COG1011	Hydrolase
I6K16_RS09870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K16_RS09880	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K16_RS09910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K16_RS09915	COG2183	response to ionizing radiation
I6K16_RS09920	COG1918	ferrous iron import across plasma membrane
I6K16_RS09925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6K16_RS09940	COG5464	transposase or invertase
I6K16_RS09950	COG1040	competence protein
I6K16_RS09960	COG2610	gluconate transmembrane transporter activity
I6K16_RS09965	COG1640	4-alpha-glucanotransferase
I6K16_RS09970	COG0058	SHG alpha-glucan phosphorylase activity
I6K16_RS09985	COG1690	Belongs to the RtcB family
I6K16_RS09990	COG4650	regulator
I6K16_RS09995	COG1349	DNA-binding transcription factor activity
I6K16_RS10010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K16_RS10050	COG3188	usher protein
I6K16_RS10055	COG3121	Chaperone
I6K16_RS10065	COG0058	SHG alpha-glucan phosphorylase activity
I6K16_RS10085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K16_RS10090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K16_RS10095	COG2095	MarC family integral membrane protein
I6K16_RS10100	COG2610	gluconate transmembrane transporter activity
I6K16_RS10105	COG3265	gluconokinase activity
I6K16_RS10110	COG1609	Transcriptional regulator
I6K16_RS10115	COG1741	Belongs to the pirin family
I6K16_RS10120	COG0673	inositol 2-dehydrogenase activity
I6K16_RS10125	COG1247	-acetyltransferase
I6K16_RS10130	COG0405	Gamma-glutamyltransferase
I6K16_RS10140	COG0584	glycerophosphoryl diester phosphodiesterase
I6K16_RS10155	COG1175	transmembrane transport
I6K16_RS10160	COG1653	transport
I6K16_RS10175	COG0410	ABC transporter
I6K16_RS10180	COG0411	ABC transporter
I6K16_RS10185	COG4177	L-phenylalanine transmembrane transporter activity
I6K16_RS10190	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS10195	COG0683	leucine binding
I6K16_RS10200	COG0456	acetyltransferase
I6K16_RS10205	COG0683	leucine binding
I6K16_RS10210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K16_RS10215	COG2177	Part of the ABC transporter FtsEX involved in
I6K16_RS10220	COG2884	Cell division ATP-binding protein ftsE
I6K16_RS10225	COG0552	protein localization to endoplasmic reticulum
I6K16_RS10230	COG0742	ribosomal rna small subunit methyltransferase
I6K16_RS10235	COG3776	membrane
I6K16_RS10245	COG3714	YhhN family
I6K16_RS10260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K16_RS10270	COG0477	Major facilitator Superfamily
I6K16_RS10275	COG0628	permease
I6K16_RS10280	COG2091	lysine biosynthetic process via aminoadipic acid
I6K16_RS10285	COG0747	negative chemotaxis
I6K16_RS10290	COG0601	transmembrane transport
I6K16_RS10295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K16_RS10325	COG0842	Transport permease protein
I6K16_RS10330	COG1129	ABC transporter
I6K16_RS10330	COG0842	Transport permease protein
I6K16_RS10335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS10345	COG2081	HI0933 family
I6K16_RS10350	COG0306	phosphate transporter
I6K16_RS10360	COG0589	response to stress
I6K16_RS10365	COG3104	oligopeptide transport
I6K16_RS10375	COG0339	signal peptide processing
I6K16_RS10380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K16_RS10385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K16_RS10395	COG0640	Transcriptional regulator
I6K16_RS10400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K16_RS10405	COG1393	Belongs to the ArsC family
I6K16_RS10425	COG3065	identical protein binding
I6K16_RS10430	COG2197	response regulator
I6K16_RS10435	COG3720	iron ion transport
I6K16_RS10440	COG4771	TonB-dependent receptor
I6K16_RS10445	COG4558	Periplasmic binding protein
I6K16_RS10455	COG3721	Heme iron utilization protein
I6K16_RS10465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS10475	COG1285	pathogenesis
I6K16_RS10490	COG3247	response to pH
I6K16_RS10495	COG2771	luxR family
I6K16_RS10505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS10510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K16_RS10515	COG2207	Transcriptional regulator
I6K16_RS10525	COG0076	glutamate decarboxylase activity
I6K16_RS10530	COG1858	cytochrome C peroxidase
I6K16_RS10540	COG2197	response regulator
I6K16_RS10545	COG0583	DNA-binding transcription factor activity
I6K16_RS10550	COG1295	ribonuclease BN
I6K16_RS10555	COG0477	Major facilitator Superfamily
I6K16_RS10560	COG2982	Protein involved in outer membrane biogenesis
I6K16_RS10565	COG2200	EAL domain
I6K16_RS10570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS10575	COG0612	Peptidase, M16
I6K16_RS10585	COG2200	EAL domain
I6K16_RS10585	COG2199	diguanylate cyclase activity
I6K16_RS10590	COG3118	belongs to the thioredoxin family
I6K16_RS10590	COG0457	Tetratricopeptide repeat
I6K16_RS10595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K16_RS10600	COG1215	transferase activity, transferring glycosyl groups
I6K16_RS10605	COG1215	transferase activity, transferring glycosyl groups
I6K16_RS10630	COG2194	sulfuric ester hydrolase activity
I6K16_RS10655	COG0814	amino acid
I6K16_RS10660	COG4608	Belongs to the ABC transporter superfamily
I6K16_RS10665	COG0444	Belongs to the ABC transporter superfamily
I6K16_RS10670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K16_RS10675	COG0601	transmembrane transport
I6K16_RS10685	COG0747	negative chemotaxis
I6K16_RS10705	COG2194	sulfuric ester hydrolase activity
I6K16_RS10710	COG2223	nitrite transmembrane transporter activity
I6K16_RS10715	COG5571	outer membrane autotransporter
I6K16_RS10720	COG2818	Glycosylase
I6K16_RS10725	COG0456	acetyltransferase
I6K16_RS10730	COG0243	molybdopterin cofactor binding
I6K16_RS10735	COG2885	chlorophyll binding
I6K16_RS10750	COG2944	sequence-specific DNA binding
I6K16_RS10755	COG1278	Cold shock
I6K16_RS10780	COG3274	enterobacterial common antigen metabolic process
I6K16_RS10785	COG4682	membrane
I6K16_RS10790	COG4682	membrane
I6K16_RS10795	COG1070	Carbohydrate kinase
I6K16_RS10805	COG4213	ABC transporter substrate-binding protein
I6K16_RS10815	COG4214	carbohydrate transport
I6K16_RS10820	COG2207	Transcriptional regulator
I6K16_RS10820	COG1609	Transcriptional regulator
I6K16_RS10825	COG2992	FlgJ-related protein
I6K16_RS10830	COG0366	Alpha amylase catalytic
I6K16_RS10835	COG3977	Valine--pyruvate aminotransferase
I6K16_RS10840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K16_RS10845	COG1414	Transcriptional regulator
I6K16_RS10855	COG2731	YhcH YjgK YiaL family protein
I6K16_RS10860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K16_RS10865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K16_RS10870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K16_RS10875	COG1070	Carbohydrate kinase
I6K16_RS10880	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K16_RS10885	COG3623	hexulose-6-phosphate isomerase
I6K16_RS10890	COG0235	Class ii aldolase
I6K16_RS10900	COG2211	Major facilitator Superfamily
I6K16_RS10910	COG3713	MltA-interacting MipA family protein
I6K16_RS10915	COG0583	DNA-binding transcription factor activity
I6K16_RS10920	COG1566	PFAM secretion protein HlyD family protein
I6K16_RS10935	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS10940	COG1454	alcohol dehydrogenase
I6K16_RS10945	COG3276	selenocysteine insertion sequence binding
I6K16_RS10955	COG0625	glutathione transferase activity
I6K16_RS10960	COG1566	PFAM secretion protein HlyD family protein
I6K16_RS10970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS10970	COG2213	PTS system mannitol-specific
I6K16_RS10980	COG3722	fumarate hydratase activity
I6K16_RS11000	COG5295	Hep Hag repeat protein
I6K16_RS11005	COG1620	l-lactate permease
I6K16_RS11010	COG2186	Transcriptional regulator
I6K16_RS11020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K16_RS11025	COG1045	serine acetyltransferase
I6K16_RS11040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K16_RS11045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K16_RS11055	COG4942	peptidase
I6K16_RS11060	COG2861	carbohydrate metabolic process
I6K16_RS11065	COG1216	Glycosyl transferase, family 2
I6K16_RS11075	COG0156	8-amino-7-oxononanoate synthase activity
I6K16_RS11085	COG0859	PFAM glycosyl transferase family 9
I6K16_RS11090	COG0859	PFAM glycosyl transferase family 9
I6K16_RS11095	COG3307	-O-antigen
I6K16_RS11105	COG1442	glycosyl transferase family 8
I6K16_RS11110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K16_RS11125	COG0515	serine threonine protein kinase
I6K16_RS11130	COG0438	transferase activity, transferring glycosyl groups
I6K16_RS11135	COG0859	PFAM glycosyl transferase family 9
I6K16_RS11140	COG1519	Transferase
I6K16_RS11170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K16_RS11195	COG1561	YicC-like family, N-terminal region
I6K16_RS11200	COG2860	membrane
I6K16_RS11210	COG0194	GDP metabolic process
I6K16_RS11220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K16_RS11225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K16_RS11230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K16_RS11235	COG0786	glutamate:sodium symporter activity
I6K16_RS11240	COG2233	PERMEase
I6K16_RS11245	COG2982	Protein involved in outer membrane biogenesis
I6K16_RS11255	COG1940	carbohydrate kinase activity
I6K16_RS11270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS11270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS11275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS11280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS11280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS11280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS11285	COG3711	transcriptional antiterminator
I6K16_RS11290	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K16_RS11295	COG2211	Major facilitator Superfamily
I6K16_RS11305	COG0582	viral genome integration into host DNA
I6K16_RS11335	COG3436	PFAM IS66 Orf2 family protein
I6K16_RS11340	COG4372	Transposase
I6K16_RS11345	COG3436	PFAM IS66 Orf2 family protein
I6K16_RS11360	COG4771	TonB-dependent receptor
I6K16_RS11380	COG1653	transport
I6K16_RS11405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS11405	COG1263	PTS System
I6K16_RS11405	COG2190	(PTS) system
I6K16_RS11410	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6K16_RS11435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6K16_RS11440	COG3959	Transketolase, thiamine diphosphate binding domain
I6K16_RS11445	COG3037	sugar-specific permease SgaT UlaA
I6K16_RS11455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS11460	COG1609	Transcriptional regulator
I6K16_RS11505	COG3436	PFAM IS66 Orf2 family protein
I6K16_RS11520	COG2826	transposase and inactivated derivatives, IS30 family
I6K16_RS11530	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6K16_RS11535	COG1120	ATPase activity
I6K16_RS11540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS11545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS11550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K16_RS11555	COG4772	TonB-dependent receptor
I6K16_RS11560	COG3712	iron ion homeostasis
I6K16_RS11565	COG1595	DNA-templated transcription, initiation
I6K16_RS11635	COG4771	TonB-dependent receptor
I6K16_RS11665	COG2378	regulation of single-species biofilm formation
I6K16_RS11690	COG2003	Belongs to the UPF0758 family
I6K16_RS11730	COG0697	spore germination
I6K16_RS11735	COG1464	Belongs to the NlpA lipoprotein family
I6K16_RS11755	COG2252	PERMEase
I6K16_RS11765	COG2271	Major facilitator Superfamily
I6K16_RS11770	COG2271	Major facilitator Superfamily
I6K16_RS11775	COG3851	Histidine kinase
I6K16_RS11780	COG2197	response regulator
I6K16_RS11785	COG0440	acetolactate synthase activity
I6K16_RS11790	COG0028	Belongs to the TPP enzyme family
I6K16_RS11805	COG2814	Major facilitator Superfamily
I6K16_RS11810	COG0641	radical SAM
I6K16_RS11820	COG2149	membrane
I6K16_RS11825	COG3119	arylsulfatase activity
I6K16_RS11830	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K16_RS11835	COG2207	Transcriptional regulator
I6K16_RS11855	COG5645	(Lipo)protein
I6K16_RS11860	COG0823	Involved in the tonB-independent uptake of proteins
I6K16_RS11865	COG0644	oxidoreductase
I6K16_RS11870	COG2271	Major facilitator Superfamily
I6K16_RS11880	COG0800	Aldolase
I6K16_RS11885	COG3734	2-keto-3-deoxy-galactonokinase
I6K16_RS11890	COG2186	Transcriptional regulator
I6K16_RS11900	COG0561	phosphatase activity
I6K16_RS11905	COG3753	Protein conserved in bacteria
I6K16_RS11910	COG0187	DNA topoisomerase II activity
I6K16_RS11920	COG0592	DNA-directed DNA polymerase activity
I6K16_RS11970	COG0814	amino acid
I6K16_RS11980	COG0583	DNA-binding transcription factor activity
I6K16_RS11985	COG2091	lysine biosynthetic process via aminoadipic acid
I6K16_RS11990	COG0431	NADPH-dependent FMN reductase
I6K16_RS11995	COG2252	PERMEase
I6K16_RS12000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K16_RS12010	COG0363	glucosamine-6-phosphate deaminase activity
I6K16_RS12015	COG2382	esterase
I6K16_RS12025	COG2723	6-phospho-beta-galactosidase activity
I6K16_RS12030	COG2190	(PTS) system
I6K16_RS12030	COG1263	PTS System
I6K16_RS12030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS12035	COG3711	transcriptional antiterminator
I6K16_RS12040	COG0704	Plays a role in the regulation of phosphate uptake
I6K16_RS12045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K16_RS12050	COG0581	inorganic phosphate transmembrane transporter activity
I6K16_RS12055	COG0573	inorganic phosphate transmembrane transporter activity
I6K16_RS12060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K16_RS12135	COG3312	ion transport
I6K16_RS12150	COG0716	FMN binding
I6K16_RS12155	COG1522	sequence-specific DNA binding
I6K16_RS12185	COG1129	ABC transporter
I6K16_RS12190	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS12195	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS12200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS12205	COG1609	Transcriptional regulator
I6K16_RS12210	COG0477	Major facilitator Superfamily
I6K16_RS12215	COG2186	Transcriptional regulator
I6K16_RS12255	COG3085	chromosome segregation
I6K16_RS12260	COG0606	chelatase, subunit chli
I6K16_RS12280	COG3978	acetolactate synthase activity
I6K16_RS12285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K16_RS12295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K16_RS12300	COG0583	DNA-binding transcription factor activity
I6K16_RS12310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K16_RS12315	COG0210	DNA helicase
I6K16_RS12330	COG3118	belongs to the thioredoxin family
I6K16_RS12340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K16_RS12345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K16_RS12350	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K16_RS12355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K16_RS12360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K16_RS12365	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K16_RS12370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K16_RS12375	COG0456	acetyltransferase
I6K16_RS12380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K16_RS12385	COG2244	polysaccharide biosynthetic process
I6K16_RS12405	COG1113	amino acid transport
I6K16_RS12430	COG0641	radical SAM
I6K16_RS12435	COG3119	arylsulfatase activity
I6K16_RS12440	COG3071	HemY protein
I6K16_RS12445	COG2959	enzyme of heme biosynthesis
I6K16_RS12450	COG1587	Uroporphyrinogen-III synthase
I6K16_RS12460	COG3072	Adenylate cyclase
I6K16_RS12480	COG5567	small periplasmic lipoprotein
I6K16_RS12490	COG3159	Protein conserved in bacteria
I6K16_RS12500	COG1011	Hydrolase
I6K16_RS12505	COG0210	DNA helicase
I6K16_RS12510	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6K16_RS12515	COG3698	Phosphodiester glycosidase
I6K16_RS12520	COG0598	Magnesium transport protein CorA
I6K16_RS12535	COG2962	Rard protein
I6K16_RS12540	COG2050	protein possibly involved in aromatic compounds catabolism
I6K16_RS12545	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6K16_RS12550	COG0514	ATP-dependent DNA helicase (RecQ)
I6K16_RS12555	COG1280	lysine exporter protein (LysE YggA)
I6K16_RS12560	COG1280	lysine exporter protein (LysE YggA)
I6K16_RS12565	COG2267	carboxylic ester hydrolase activity
I6K16_RS12570	COG0561	phosphatase activity
I6K16_RS12575	COG0697	spore germination
I6K16_RS12580	COG0583	DNA-binding transcription factor activity
I6K16_RS12595	COG2190	(PTS) system
I6K16_RS12595	COG1263	PTS System
I6K16_RS12595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS12600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K16_RS12605	COG1737	Transcriptional regulator
I6K16_RS12610	COG0583	DNA-binding transcription factor activity
I6K16_RS12615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K16_RS12625	COG0549	Belongs to the carbamate kinase family
I6K16_RS12630	COG1304	FMN binding
I6K16_RS12635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K16_RS12645	COG1335	isochorismatase
I6K16_RS12650	COG0412	Dienelactone hydrolase
I6K16_RS12655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6K16_RS12675	COG0800	Aldolase
I6K16_RS12680	COG3734	2-keto-3-deoxy-galactonokinase
I6K16_RS12685	COG1414	Transcriptional regulator
I6K16_RS12690	COG1322	Protein conserved in bacteria
I6K16_RS12700	COG3165	ubiquinone biosynthetic process from chorismate
I6K16_RS12710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K16_RS12715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K16_RS12720	COG0805	protein transport
I6K16_RS12730	COG0250	Participates in transcription elongation, termination and antitermination
I6K16_RS12735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K16_RS12740	COG0543	2 iron, 2 sulfur cluster binding
I6K16_RS12745	COG0183	Belongs to the thiolase family
I6K16_RS12760	COG1739	Uncharacterized protein family UPF0029
I6K16_RS12765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K16_RS12770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K16_RS12800	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K16_RS12805	COG0746	molybdenum cofactor guanylyltransferase activity
I6K16_RS12810	COG3084	Protein conserved in bacteria
I6K16_RS12815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K16_RS12820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K16_RS12825	COG5339	Protein conserved in bacteria
I6K16_RS12830	COG0204	Acyl-transferase
I6K16_RS12835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K16_RS12835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K16_RS12850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K16_RS12860	COG2204	response regulator
I6K16_RS12865	COG3852	Histidine kinase
I6K16_RS12870	COG0174	glutamine synthetase
I6K16_RS12875	COG1217	gtp-binding protein TYPA
I6K16_RS12880	COG2188	Transcriptional regulator
I6K16_RS12885	COG1082	Xylose isomerase domain protein TIM barrel
I6K16_RS12890	COG2271	Major facilitator Superfamily
I6K16_RS12895	COG1349	DNA-binding transcription factor activity
I6K16_RS12900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS12905	COG2084	Dehydrogenase
I6K16_RS12910	COG3684	Belongs to the aldolase LacD family
I6K16_RS12915	COG1063	alcohol dehydrogenase
I6K16_RS12925	COG0477	Major facilitator Superfamily
I6K16_RS12935	COG1011	Hydrolase
I6K16_RS12950	COG0456	acetyltransferase
I6K16_RS12960	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K16_RS12970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K16_RS12980	COG2864	formate dehydrogenase
I6K16_RS12985	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS13020	COG4806	L-rhamnose isomerase
I6K16_RS13045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K16_RS13055	COG2258	MOSC domain
I6K16_RS13060	COG2205	protein histidine kinase activity
I6K16_RS13065	COG0745	RESPONSE REGULATOR receiver
I6K16_RS13070	COG3678	ATP-independent chaperone mediated protein folding
I6K16_RS13085	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K16_RS13105	COG3152	Membrane
I6K16_RS13110	COG3691	Protein conserved in bacteria
I6K16_RS13115	COG0589	response to stress
I6K16_RS13125	COG1494	fructose-1,6-bisphosphatase
I6K16_RS13135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K16_RS13150	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K16_RS13165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K16_RS13170	COG1609	Transcriptional regulator
I6K16_RS13175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K16_RS13185	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K16_RS13195	COG0626	cystathionine gamma-synthase activity
I6K16_RS13200	COG0527	aspartate kinase activity
I6K16_RS13200	COG0460	homoserine dehydrogenase
I6K16_RS13210	COG0737	Belongs to the 5'-nucleotidase family
I6K16_RS13215	COG0737	Belongs to the 5'-nucleotidase family
I6K16_RS13225	COG0737	Belongs to the 5'-nucleotidase family
I6K16_RS13230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K16_RS13240	COG0697	spore germination
I6K16_RS13245	COG3738	Protein conserved in bacteria
I6K16_RS13250	COG0371	Dehydrogenase
I6K16_RS13255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K16_RS13260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K16_RS13260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS13260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS13265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS13270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS13275	COG1882	Formate acetyltransferase
I6K16_RS13280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K16_RS13285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K16_RS13290	COG2207	Transcriptional regulator
I6K16_RS13295	COG2194	sulfuric ester hydrolase activity
I6K16_RS13310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K16_RS13325	COG4948	Mandelate Racemase Muconate Lactonizing
I6K16_RS13330	COG2271	Major facilitator Superfamily
I6K16_RS13335	COG0583	DNA-binding transcription factor activity
I6K16_RS13345	COG1309	transcriptional regulator
I6K16_RS13395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K16_RS13395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K16_RS13430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K16_RS13435	COG0250	Participates in transcription elongation, termination and antitermination
I6K16_RS13470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K16_RS13480	COG2104	thiamine diphosphate biosynthetic process
I6K16_RS13485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K16_RS13520	COG3068	Protein conserved in bacteria
I6K16_RS13535	COG3678	ATP-independent chaperone mediated protein folding
I6K16_RS13540	COG4191	Histidine kinase
I6K16_RS13545	COG2204	response regulator
I6K16_RS13550	COG0151	Belongs to the GarS family
I6K16_RS13580	COG0456	acetyltransferase
I6K16_RS13590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K16_RS13595	COG2224	Isocitrate lyase
I6K16_RS13605	COG1414	Transcriptional regulator
I6K16_RS13610	COG0646	methionine synthase
I6K16_RS13610	COG1410	methionine synthase
I6K16_RS13615	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K16_RS13660	COG1187	pseudouridine synthase activity
I6K16_RS13670	COG0527	aspartate kinase activity
I6K16_RS13695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K16_RS13710	COG3833	ABC-type maltose transport systems, permease component
I6K16_RS13715	COG1175	transmembrane transport
I6K16_RS13720	COG2182	Extracellular solute-binding protein
I6K16_RS13725	COG3842	ATPase activity
I6K16_RS13755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K16_RS13765	COG0534	Mate efflux family protein
I6K16_RS13770	COG3237	CsbD-like
I6K16_RS13775	COG0735	belongs to the Fur family
I6K16_RS13780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K16_RS13790	COG0604	alcohol dehydrogenase
I6K16_RS13795	COG0305	Participates in initiation and elongation during chromosome replication
I6K16_RS13800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K16_RS13805	COG1448	Aminotransferase
I6K16_RS13815	COG3700	Belongs to the class B bacterial acid phosphatase family
I6K16_RS13820	COG0432	Pfam Uncharacterised protein family UPF0047
I6K16_RS13825	COG2315	Protein conserved in bacteria
I6K16_RS13830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K16_RS13835	COG0629	single-stranded DNA binding
I6K16_RS13845	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K16_RS13850	COG2207	Transcriptional regulator
I6K16_RS13855	COG0789	Transcriptional regulator
I6K16_RS13860	COG2252	PERMEase
I6K16_RS13865	COG0025	NhaP-type Na H and K H
I6K16_RS13875	COG3162	membrane
I6K16_RS13880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K16_RS13890	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6K16_RS13895	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS13900	COG3301	Polysulphide reductase, NrfD
I6K16_RS13905	COG1138	Cytochrome C-type biogenesis protein
I6K16_RS13910	COG3088	subunit of a heme lyase
I6K16_RS13915	COG4235	cytochrome complex assembly
I6K16_RS13920	COG1301	dicarboxylic acid transport
I6K16_RS13925	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K16_RS13940	COG1289	transmembrane transporter activity
I6K16_RS13945	COG1566	PFAM secretion protein HlyD family protein
I6K16_RS13955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K16_RS13960	COG1940	carbohydrate kinase activity
I6K16_RS13965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K16_RS13970	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS13975	COG1129	ABC transporter
I6K16_RS13980	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS13985	COG1737	Transcriptional regulator
I6K16_RS13990	COG0698	ribose 5-phosphate isomerase
I6K16_RS14000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K16_RS14005	COG0456	acetyltransferase
I6K16_RS14015	COG3454	Phosphonate metabolism
I6K16_RS14020	COG4778	phosphonate C-P lyase system protein PhnL
I6K16_RS14025	COG4107	phosphonate C-P lyase system protein PhnK
I6K16_RS14030	COG3627	carbon phosphorus lyase activity
I6K16_RS14035	COG3626	phosphonate metabolism
I6K16_RS14040	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K16_RS14045	COG3624	Phosphonate C-P lyase system protein PhnG
I6K16_RS14050	COG2188	Transcriptional regulator
I6K16_RS14055	COG3639	organic phosphonate transmembrane transporter activity
I6K16_RS14060	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K16_RS14070	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K16_RS14075	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K16_RS14090	COG0477	Major facilitator Superfamily
I6K16_RS14100	COG0642	Histidine kinase
I6K16_RS14105	COG0745	RESPONSE REGULATOR receiver
I6K16_RS14110	COG2194	sulfuric ester hydrolase activity
I6K16_RS14115	COG0531	amino acid
I6K16_RS14120	COG2207	Transcriptional regulator
I6K16_RS14125	COG1982	Orn Lys Arg decarboxylase major
I6K16_RS14130	COG2169	Transcriptional regulator
I6K16_RS14135	COG1486	melibiose metabolic process
I6K16_RS14140	COG2211	Major facilitator Superfamily
I6K16_RS14145	COG3647	Membrane
I6K16_RS14150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K16_RS14150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K16_RS14155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K16_RS14160	COG4565	transcriptional regulatory protein
I6K16_RS14165	COG3290	protein histidine kinase activity
I6K16_RS14170	COG3592	Divergent 4Fe-4S mono-cluster
I6K16_RS14175	COG2388	GCN5-related N-acetyl-transferase
I6K16_RS14190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K16_RS14195	COG3104	oligopeptide transport
I6K16_RS14200	COG1982	Orn Lys Arg decarboxylase major
I6K16_RS14205	COG0531	amino acid
I6K16_RS14210	COG3710	Transcriptional regulator
I6K16_RS14220	COG1309	transcriptional regulator
I6K16_RS14225	COG4232	protein-disulfide reductase activity
I6K16_RS14235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K16_RS14240	COG1027	Aspartate ammonia-lyase
I6K16_RS14245	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K16_RS14250	COG0531	amino acid
I6K16_RS14275	COG1509	lysine 2,3-aminomutase activity
I6K16_RS14285	COG5510	response to toxic substance
I6K16_RS14290	COG5510	response to toxic substance
I6K16_RS14295	COG2076	Multidrug Resistance protein
I6K16_RS14300	COG3040	lipid binding
I6K16_RS14305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K16_RS14320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K16_RS14325	COG1053	succinate dehydrogenase
I6K16_RS14335	COG0531	amino acid
I6K16_RS14350	COG3264	Mechanosensitive ion channel
I6K16_RS14350	COG1511	domain protein
I6K16_RS14395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K16_RS14395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K16_RS14400	COG0802	atpase or kinase
I6K16_RS14405	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K16_RS14425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K16_RS14430	COG0330	HflC and HflK could
I6K16_RS14435	COG0330	HflC and HflK could
I6K16_RS14440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K16_RS14455	COG0557	exoribonuclease II activity
I6K16_RS14460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K16_RS14465	COG3789	protein conserved in bacteria
I6K16_RS14470	COG1842	Phage shock protein A
I6K16_RS14480	COG3766	membrane
I6K16_RS14485	COG5463	Belongs to the UPF0441 family
I6K16_RS14490	COG0754	glutathionylspermidine amidase activity
I6K16_RS14495	COG1960	acyl-CoA dehydrogenase activity
I6K16_RS14505	COG3650	response to hydrogen peroxide
I6K16_RS14510	COG1073	alpha beta
I6K16_RS14525	COG3037	sugar-specific permease SgaT UlaA
I6K16_RS14530	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K16_RS14570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K16_RS14590	COG2271	Major facilitator Superfamily
I6K16_RS14595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K16_RS14600	COG4670	ketone body catabolic process
I6K16_RS14605	COG1024	Enoyl-CoA hydratase
I6K16_RS14620	COG1309	transcriptional regulator
I6K16_RS14625	COG3061	Opacity-associated protein A
I6K16_RS14630	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K16_RS14635	COG1113	amino acid transport
I6K16_RS14655	COG0697	spore germination
I6K16_RS14660	COG0702	epimerase
I6K16_RS14665	COG1733	regulation of RNA biosynthetic process
I6K16_RS14670	COG0737	Belongs to the 5'-nucleotidase family
I6K16_RS14675	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6K16_RS14685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K16_RS14695	COG1253	flavin adenine dinucleotide binding
I6K16_RS14705	COG0729	surface antigen
I6K16_RS14710	COG2911	Protein conserved in bacteria
I6K16_RS14715	COG2105	PFAM AIG2 family protein
I6K16_RS14720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K16_RS14725	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS14735	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS14740	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS14750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K16_RS14755	COG3028	Belongs to the UPF0307 family
I6K16_RS14760	COG0312	modulator of DNA gyrase
I6K16_RS14765	COG3783	Cytochrome b(562)
I6K16_RS14770	COG0602	queuosine metabolic process
I6K16_RS14775	COG1328	CTP reductase activity
I6K16_RS14780	COG0366	Alpha amylase catalytic
I6K16_RS14785	COG1263	PTS System
I6K16_RS14785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS14790	COG1609	Transcriptional regulator
I6K16_RS14800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K16_RS14805	COG0251	oxidation-reduction process
I6K16_RS14825	COG0251	oxidation-reduction process
I6K16_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS14835	COG1309	transcriptional regulator
I6K16_RS14840	COG2731	YhcH YjgK YiaL family protein
I6K16_RS14855	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6K16_RS14860	COG0456	acetyltransferase
I6K16_RS14865	COG4269	membrane
I6K16_RS14870	COG0525	valine-tRNA ligase activity
I6K16_RS14875	COG2927	DNA polymerase III (CHI subunit)
I6K16_RS14885	COG0795	lipopolysaccharide-transporting ATPase activity
I6K16_RS14890	COG0795	lipopolysaccharide-transporting ATPase activity
I6K16_RS14895	COG0433	COG0433 Predicted ATPase
I6K16_RS14900	COG1064	alcohol dehydrogenase
I6K16_RS14940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K16_RS14945	COG0582	viral genome integration into host DNA
I6K16_RS14950	COG4974	Belongs to the 'phage' integrase family
I6K16_RS14960	COG3539	Fimbrial protein
I6K16_RS14965	COG3121	Chaperone
I6K16_RS14970	COG3188	usher protein
I6K16_RS14975	COG3539	Fimbrial protein
I6K16_RS14980	COG3539	Fimbrial protein
I6K16_RS14985	COG3539	Fimbrial protein
I6K16_RS14990	COG2610	gluconate transmembrane transporter activity
I6K16_RS15000	COG0246	Mannitol dehydrogenase
I6K16_RS15005	COG2186	Transcriptional regulator
I6K16_RS15020	COG0583	DNA-binding transcription factor activity
I6K16_RS15025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K16_RS15030	COG0700	Nucleoside recognition
I6K16_RS15035	COG3366	ferrous iron transmembrane transporter activity
I6K16_RS15045	COG0477	Major facilitator Superfamily
I6K16_RS15060	COG1924	4 iron, 4 sulfur cluster binding
I6K16_RS15070	COG2733	membrane
I6K16_RS15075	COG2814	Major facilitator Superfamily
I6K16_RS15085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K16_RS15090	COG5457	Domain of unknown function (DUF1127)
I6K16_RS15100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6K16_RS15105	COG0732	type I restriction modification DNA specificity domain
I6K16_RS15110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K16_RS15115	COG1715	Restriction endonuclease
I6K16_RS15130	COG0523	cobalamin synthesis protein
I6K16_RS15135	COG2879	small protein
I6K16_RS15140	COG1966	Carbon starvation protein
I6K16_RS15150	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K16_RS15160	COG4145	pantothenate transmembrane transporter activity
I6K16_RS15170	COG0840	transmembrane signaling receptor activity
I6K16_RS15180	COG1802	Transcriptional regulator
I6K16_RS15185	COG1063	alcohol dehydrogenase
I6K16_RS15190	COG1368	sulfuric ester hydrolase activity
I6K16_RS15200	COG1484	DNA-dependent DNA replication
I6K16_RS15215	COG2966	Psort location CytoplasmicMembrane, score
I6K16_RS15220	COG2197	response regulator
I6K16_RS15225	COG2197	response regulator
I6K16_RS15230	COG4114	ferric iron reductase
I6K16_RS15260	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K16_RS15265	COG0456	acetyltransferase
I6K16_RS15270	COG1011	Hydrolase
I6K16_RS15280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K16_RS15295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K16_RS15300	COG5532	Uncharacterized conserved protein (DUF2303)
I6K16_RS15310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K16_RS15315	COG4197	protein conserved in bacteria, prophage-related
I6K16_RS15335	COG1846	Transcriptional regulator
I6K16_RS15345	COG4725	Belongs to the MT-A70-like family
I6K16_RS15355	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K16_RS15365	COG1403	HNH endonuclease
I6K16_RS15370	COG0484	heat shock protein binding
I6K16_RS15390	COG3772	lysozyme
I6K16_RS15405	COG4220	transposase activity
I6K16_RS15425	COG1030	water channel activity
I6K16_RS15475	COG1196	nuclear chromosome segregation
I6K16_RS15510	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS15515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K16_RS15540	COG2823	Periplasmic or secreted lipoprotein
I6K16_RS15550	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K16_RS15555	COG0084	hydrolase, TatD family'
I6K16_RS15560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K16_RS15565	COG1328	CTP reductase activity
I6K16_RS15600	COG3726	membrane protein affecting hemolysin expression
I6K16_RS15605	COG0560	Phosphoserine phosphatase
I6K16_RS15610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K16_RS15615	COG1056	cytidyltransferase-related domain
I6K16_RS15615	COG3172	ATPase kinase involved in NAD metabolism
I6K16_RS15620	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K16_RS15630	COG0488	(ABC) transporter
I6K16_RS15635	COG0741	lytic transglycosylase activity
I6K16_RS15655	COG3708	Transcriptional regulator
I6K16_RS15655	COG2207	Transcriptional regulator
I6K16_RS15660	COG3045	CreA protein
I6K16_RS15665	COG0745	RESPONSE REGULATOR receiver
I6K16_RS15670	COG2205	protein histidine kinase activity
I6K16_RS15675	COG4452	Inner membrane protein CreD
I6K16_RS15680	COG0745	RESPONSE REGULATOR receiver
I6K16_RS15690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K16_RS15700	COG0460	homoserine dehydrogenase
I6K16_RS15700	COG0527	aspartate kinase activity
I6K16_RS15710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K16_RS15725	COG1115	amino acid carrier protein
I6K16_RS15735	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K16_RS15740	COG1584	GPR1 FUN34 yaaH family protein
I6K16_RS15745	COG4735	regulation of single-species biofilm formation
I6K16_RS15775	COG0583	DNA-binding transcription factor activity
I6K16_RS15790	COG0196	riboflavin kinase activity
I6K16_RS15805	COG1047	Peptidyl-prolyl cis-trans
I6K16_RS15825	COG0505	Belongs to the CarA family
I6K16_RS15830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K16_RS15880	COG0644	oxidoreductase
I6K16_RS15885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K16_RS15890	COG2271	Major facilitator Superfamily
I6K16_RS15905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K16_RS15945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K16_RS15955	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K16_RS15960	COG0564	pseudouridine synthase activity
I6K16_RS15970	COG0417	DNA replication proofreading
I6K16_RS15975	COG0235	Class ii aldolase
I6K16_RS15990	COG4977	sequence-specific DNA binding
I6K16_RS15995	COG0586	Pfam SNARE associated Golgi protein
I6K16_RS16005	COG1178	ABC-type Fe3 transport system permease component
I6K16_RS16010	COG4143	(ABC) transporter
I6K16_RS16035	COG0473	3-isopropylmalate dehydrogenase activity
I6K16_RS16050	COG0583	DNA-binding transcription factor activity
I6K16_RS16060	COG0028	Belongs to the TPP enzyme family
I6K16_RS16065	COG0440	acetolactate synthase activity
I6K16_RS16075	COG1609	Transcriptional regulator
I6K16_RS16090	COG3116	cell division
I6K16_RS16095	COG0768	penicillin binding
I6K16_RS16100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K16_RS16105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K16_RS16120	COG0772	Belongs to the SEDS family
I6K16_RS16135	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K16_RS16140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K16_RS16145	COG0849	cell division
I6K16_RS16150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K16_RS16170	COG0494	nUDIX hydrolase
I6K16_RS16185	COG0237	dephospho-CoA kinase activity
I6K16_RS16200	COG1459	type II secretion system
I6K16_RS16205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K16_RS16210	COG4969	Belongs to the N-Me-Phe pilin family
I6K16_RS16215	COG0157	Belongs to the NadC ModD family
I6K16_RS16220	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K16_RS16225	COG3725	Membrane protein required for beta-lactamase induction
I6K16_RS16230	COG1113	amino acid transport
I6K16_RS16235	COG2186	Transcriptional regulator
I6K16_RS16240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K16_RS16245	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K16_RS16250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K16_RS16255	COG3064	Membrane
I6K16_RS16260	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6K16_RS16285	COG2132	Multicopper oxidase
I6K16_RS16290	COG4993	Dehydrogenase
I6K16_RS16295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K16_RS16300	COG0288	reversible hydration of carbon dioxide
I6K16_RS16305	COG1131	(ABC) transporter
I6K16_RS16310	COG0842	Transport permease protein
I6K16_RS16315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS16320	COG0726	polysaccharide deacetylase
I6K16_RS16330	COG5464	transposase or invertase
I6K16_RS16335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6K16_RS16345	COG3539	Fimbrial protein
I6K16_RS16350	COG3539	Fimbrial protein
I6K16_RS16355	COG3539	Fimbrial protein
I6K16_RS16360	COG3539	Fimbrial protein
I6K16_RS16365	COG3188	usher protein
I6K16_RS16370	COG3121	Chaperone
I6K16_RS16375	COG3539	Fimbrial protein
I6K16_RS16380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K16_RS16385	COG0617	tRNA 3'-terminal CCA addition
I6K16_RS16390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K16_RS16395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K16_RS16405	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K16_RS16410	COG1643	Atp-dependent helicase
I6K16_RS16415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K16_RS16420	COG4774	siderophore transport
I6K16_RS16425	COG1120	ATPase activity
I6K16_RS16430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K16_RS16435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS16460	COG2860	membrane
I6K16_RS16465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K16_RS16480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K16_RS16485	COG3835	regulator
I6K16_RS16495	COG1408	metallophosphoesterase
I6K16_RS16510	COG0024	Methionine aminopeptidase
I6K16_RS16535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K16_RS16540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K16_RS16545	COG0575	Belongs to the CDS family
I6K16_RS16550	COG0750	zinc metalloprotease
I6K16_RS16560	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K16_RS16565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K16_RS16590	COG0587	DNA-directed DNA polymerase activity
I6K16_RS16600	COG1982	Orn Lys Arg decarboxylase major
I6K16_RS16605	COG0346	lactoylglutathione lyase activity
I6K16_RS16610	COG0037	tRNA processing
I6K16_RS16615	COG4568	rho-dependent transcription termination
I6K16_RS16625	COG4681	YaeQ
I6K16_RS16630	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K16_RS16635	COG3015	lipoprotein NlpE involved in copper resistance
I6K16_RS16640	COG0791	NLP P60 protein
I6K16_RS16650	COG1720	tRNA m6t6A37 methyltransferase activity
I6K16_RS16660	COG1464	Belongs to the NlpA lipoprotein family
I6K16_RS16665	COG2011	ABC-type metal ion transport system permease component
I6K16_RS16670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K16_RS16675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K16_RS16710	COG0656	L-ascorbic acid biosynthetic process
I6K16_RS16715	COG0583	DNA-binding transcription factor activity
I6K16_RS16725	COG2226	methyltransferase
I6K16_RS16730	COG0741	lytic transglycosylase activity
I6K16_RS16730	COG1388	LysM domain
I6K16_RS16735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K16_RS16740	COG2226	methyltransferase
I6K16_RS16750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K16_RS16770	COG3436	PFAM IS66 Orf2 family protein
I6K16_RS16810	COG2003	Belongs to the UPF0758 family
I6K16_RS16875	COG0582	viral genome integration into host DNA
I6K16_RS16900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS16905	COG1120	ATPase activity
I6K16_RS16980	COG0823	Involved in the tonB-independent uptake of proteins
I6K16_RS16985	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS16990	COG1917	Cupin 2, conserved barrel domain protein
I6K16_RS16995	COG2211	Major facilitator Superfamily
I6K16_RS17025	COG1349	DNA-binding transcription factor activity
I6K16_RS17035	COG0738	Major facilitator superfamily
I6K16_RS17050	COG3037	sugar-specific permease SgaT UlaA
I6K16_RS17060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS17090	COG3436	PFAM IS66 Orf2 family protein
I6K16_RS17095	COG4372	Transposase
I6K16_RS17110	COG3210	domain, Protein
I6K16_RS17115	COG3210	domain, Protein
I6K16_RS17135	COG3468	outer membrane autotransporter barrel domain protein
I6K16_RS17135	COG3210	domain, Protein
I6K16_RS17180	COG2197	response regulator
I6K16_RS17200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K16_RS17210	COG1960	acyl-CoA dehydrogenase activity
I6K16_RS17220	COG0121	glutamine amidotransferase
I6K16_RS17225	COG3034	peptidoglycan biosynthetic process
I6K16_RS17230	COG0791	NLP P60 protein
I6K16_RS17245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K16_RS17250	COG0454	-acetyltransferase
I6K16_RS17255	COG1690	Belongs to the RtcB family
I6K16_RS17260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K16_RS17265	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K16_RS17285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K16_RS17305	COG0582	viral genome integration into host DNA
I6K16_RS17335	COG3477	response to acidic pH
I6K16_RS17340	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K16_RS17405	COG0667	Aldo Keto reductase
I6K16_RS17410	COG0656	L-ascorbic acid biosynthetic process
I6K16_RS17415	COG1388	LysM domain
I6K16_RS17420	COG2207	Transcriptional regulator
I6K16_RS17420	COG3708	Transcriptional regulator
I6K16_RS17425	COG0656	L-ascorbic acid biosynthetic process
I6K16_RS17430	COG3059	membrane
I6K16_RS17440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K16_RS17445	COG2207	Transcriptional regulator
I6K16_RS17450	COG0247	lactate metabolic process
I6K16_RS17455	COG1139	Iron-sulfur cluster binding protein
I6K16_RS17460	COG1556	Lactate utilization protein
I6K16_RS17470	COG3468	outer membrane autotransporter barrel domain protein
I6K16_RS17485	COG2200	EAL domain
I6K16_RS17485	COG2771	luxR family
I6K16_RS17490	COG0582	viral genome integration into host DNA
I6K16_RS17510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K16_RS17520	COG2200	EAL domain
I6K16_RS17520	COG2771	luxR family
I6K16_RS17525	COG0583	DNA-binding transcription factor activity
I6K16_RS17535	COG0666	response to abiotic stimulus
I6K16_RS17545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K16_RS17550	COG1304	FMN binding
I6K16_RS17560	COG0549	Belongs to the carbamate kinase family
I6K16_RS17565	COG0402	S-adenosylhomocysteine deaminase activity
I6K16_RS17575	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS17580	COG1129	ABC transporter
I6K16_RS17585	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K16_RS17595	COG1064	alcohol dehydrogenase
I6K16_RS17605	COG1280	lysine exporter protein (LysE YggA)
I6K16_RS17615	COG3829	transcription factor binding
I6K16_RS17620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K16_RS17625	COG0372	Belongs to the citrate synthase family
I6K16_RS17630	COG2079	MmgE PrpD family protein
I6K16_RS17635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K16_RS17640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K16_RS17645	COG0402	S-adenosylhomocysteine deaminase activity
I6K16_RS17650	COG0583	DNA-binding transcription factor activity
I6K16_RS17655	COG0288	reversible hydration of carbon dioxide
I6K16_RS17665	COG2807	transmembrane transport
I6K16_RS17670	COG0110	maltose O-acetyltransferase activity
I6K16_RS17675	COG2223	nitrite transmembrane transporter activity
I6K16_RS17685	COG1609	Transcriptional regulator
I6K16_RS17690	COG1414	Transcriptional regulator
I6K16_RS17725	COG2814	Major facilitator Superfamily
I6K16_RS17730	COG3122	Protein conserved in bacteria
I6K16_RS17760	COG1215	transferase activity, transferring glycosyl groups
I6K16_RS17765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K16_RS17770	COG4521	taurine ABC transporter
I6K16_RS17780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K16_RS17785	COG2175	clavaminate synthase activity
I6K16_RS17790	COG0113	porphobilinogen synthase activity
I6K16_RS17795	COG3468	outer membrane autotransporter barrel domain protein
I6K16_RS17800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K16_RS17805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K16_RS17810	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K16_RS17830	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K16_RS17845	COG1785	Belongs to the alkaline phosphatase family
I6K16_RS17855	COG3706	GGDEF domain
I6K16_RS17860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K16_RS17880	COG4126	flavin adenine dinucleotide binding
I6K16_RS17905	COG1940	carbohydrate kinase activity
I6K16_RS17910	COG2814	Major facilitator Superfamily
I6K16_RS17915	COG0419	ATPase involved in DNA repair
I6K16_RS17920	COG0420	3'-5' exonuclease activity
I6K16_RS17925	COG0745	RESPONSE REGULATOR receiver
I6K16_RS17930	COG5002	protein histidine kinase activity
I6K16_RS17935	COG1114	Component of the transport system for branched-chain amino acids
I6K16_RS17940	COG1113	amino acid transport
I6K16_RS17945	COG0366	Alpha amylase catalytic
I6K16_RS17965	COG1862	Preprotein translocase
I6K16_RS17970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K16_RS17975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K16_RS17980	COG1403	HNH endonuclease
I6K16_RS17985	COG3248	Nucleoside-binding outer membrane protein
I6K16_RS17990	COG4238	major outer membrane lipoprotein
I6K16_RS18000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K16_RS18000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K16_RS18015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K16_RS18020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K16_RS18025	COG0667	Aldo Keto reductase
I6K16_RS18035	COG0142	geranyltranstransferase activity
I6K16_RS18050	COG0693	protein deglycase activity
I6K16_RS18055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K16_RS18065	COG2814	Major facilitator Superfamily
I6K16_RS18075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K16_RS18080	COG1845	cytochrome c oxidase, subunit III
I6K16_RS18085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K16_RS18090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K16_RS18095	COG2223	nitrite transmembrane transporter activity
I6K16_RS18100	COG3056	Lipoprotein
I6K16_RS18105	COG0271	Belongs to the BolA IbaG family
I6K16_RS18125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K16_RS18130	COG0776	regulation of translation
I6K16_RS18135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K16_RS18140	COG1555	photosystem II stabilization
I6K16_RS18145	COG0824	Thioesterase
I6K16_RS18155	COG4533	DNA binding
I6K16_RS18165	COG1522	sequence-specific DNA binding
I6K16_RS18170	COG1132	(ABC) transporter
I6K16_RS18175	COG1132	(ABC) transporter
I6K16_RS18180	COG0347	Belongs to the P(II) protein family
I6K16_RS18185	COG0004	ammonium transporteR
I6K16_RS18190	COG1946	Acyl-CoA thioesterase
I6K16_RS18195	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K16_RS18200	COG3695	enzyme binding
I6K16_RS18210	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K16_RS18215	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K16_RS18225	COG0110	maltose O-acetyltransferase activity
I6K16_RS18240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K16_RS18245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS18250	COG1309	transcriptional regulator
I6K16_RS18255	COG1196	nuclear chromosome segregation
I6K16_RS18255	COG3264	Mechanosensitive ion channel
I6K16_RS18265	COG3923	Primosomal replication protein n
I6K16_RS18270	COG2832	Protein of unknown function (DUF454)
I6K16_RS18280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K16_RS18315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K16_RS18320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K16_RS18320	COG4651	solute:proton antiporter activity
I6K16_RS18325	COG2223	nitrite transmembrane transporter activity
I6K16_RS18330	COG0737	Belongs to the 5'-nucleotidase family
I6K16_RS18335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K16_RS18340	COG3735	TraB family
I6K16_RS18345	COG3549	Plasmid maintenance system killer
I6K16_RS18350	COG3093	addiction module antidote protein HigA
I6K16_RS18355	COG2217	Heavy metal translocating P-type atpase
I6K16_RS18365	COG0531	amino acid
I6K16_RS18370	COG0789	Transcriptional regulator
I6K16_RS18395	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K16_RS18400	COG0330	HflC and HflK could
I6K16_RS18405	COG4619	ABC transporter
I6K16_RS18410	COG0390	transport system, permease component
I6K16_RS18415	COG3118	belongs to the thioredoxin family
I6K16_RS18420	COG0300	oxidoreductase activity
I6K16_RS18425	COG2755	lipolytic protein G-D-S-L family
I6K16_RS18430	COG4181	ATPase activity
I6K16_RS18435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K16_RS18455	COG1414	Transcriptional regulator
I6K16_RS18460	COG3960	tartronate-semialdehyde synthase activity
I6K16_RS18465	COG3622	Belongs to the hyi family
I6K16_RS18470	COG2084	Dehydrogenase
I6K16_RS18475	COG1953	Uracil, thiamine, allantoin
I6K16_RS18485	COG2233	PERMEase
I6K16_RS18490	COG1929	Belongs to the glycerate kinase type-1 family
I6K16_RS18495	COG3257	ureidoglycine aminohydrolase activity
I6K16_RS18500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K16_RS18505	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K16_RS18510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K16_RS18515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K16_RS18525	COG0549	Belongs to the carbamate kinase family
I6K16_RS18530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K16_RS18535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K16_RS18545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K16_RS18555	COG1988	membrane-bound metal-dependent
I6K16_RS18560	COG2501	S4 domain
I6K16_RS18585	COG0500	methyltransferase
I6K16_RS18590	COG4571	Outer membrane protease
I6K16_RS18605	COG1215	transferase activity, transferring glycosyl groups
I6K16_RS18610	COG5002	protein histidine kinase activity
I6K16_RS18615	COG0745	RESPONSE REGULATOR receiver
I6K16_RS18620	COG1538	Outer membrane efflux protein
I6K16_RS18625	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS18630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS18635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K16_RS18640	COG1113	amino acid transport
I6K16_RS18645	COG0668	transmembrane transport
I6K16_RS18650	COG0778	Nitroreductase
I6K16_RS18655	COG2315	Protein conserved in bacteria
I6K16_RS18680	COG2977	Belongs to the P-Pant transferase superfamily
I6K16_RS18685	COG4771	TonB-dependent receptor
I6K16_RS18690	COG2382	esterase
I6K16_RS18695	COG3251	PFAM MbtH domain protein
I6K16_RS18700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K16_RS18700	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K16_RS18705	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K16_RS18710	COG1120	ATPase activity
I6K16_RS18715	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS18720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS18730	COG4592	Periplasmic binding protein
I6K16_RS18735	COG1169	isochorismate synthase
I6K16_RS18740	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K16_RS18745	COG1535	isochorismatase
I6K16_RS18745	COG3433	isochorismatase activity
I6K16_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS18755	COG2050	protein possibly involved in aromatic compounds catabolism
I6K16_RS18760	COG1966	Carbon starvation protein
I6K16_RS18765	COG2879	small protein
I6K16_RS18770	COG0371	Dehydrogenase
I6K16_RS18775	COG0436	Aminotransferase
I6K16_RS18780	COG1475	DNA binding
I6K16_RS18785	COG3969	phosphoadenosine phosphosulfate
I6K16_RS18790	COG0583	DNA-binding transcription factor activity
I6K16_RS18795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K16_RS18800	COG0450	alkyl hydroperoxide reductase
I6K16_RS18805	COG3634	alkyl hydroperoxide reductase activity
I6K16_RS18810	COG0589	response to stress
I6K16_RS18815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K16_RS18820	COG3719	Belongs to the RNase T2 family
I6K16_RS18825	COG0471	metal ion transport
I6K16_RS18840	COG3051	citrate lyase alpha subunit
I6K16_RS18845	COG2301	Belongs to the HpcH HpaI aldolase family
I6K16_RS18855	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6K16_RS18860	COG3290	protein histidine kinase activity
I6K16_RS18865	COG4565	transcriptional regulatory protein
I6K16_RS18870	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K16_RS18890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K16_RS18895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K16_RS18905	COG0583	DNA-binding transcription factor activity
I6K16_RS18920	COG1686	Belongs to the peptidase S11 family
I6K16_RS18925	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K16_RS18930	COG0772	Belongs to the SEDS family
I6K16_RS18935	COG0768	penicillin binding
I6K16_RS18945	COG0799	negative regulation of ribosome biogenesis
I6K16_RS18950	COG0406	alpha-ribazole phosphatase activity
I6K16_RS18960	COG1466	dna polymerase III delta subunit
I6K16_RS18975	COG2888	peptidyl-tyrosine sulfation
I6K16_RS18985	COG1126	abc transporter atp-binding protein
I6K16_RS18990	COG0765	amino acid transport
I6K16_RS18995	COG0765	amino acid transport
I6K16_RS19000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS19010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6K16_RS19015	COG4535	Mg2 and Co2 transporter CorC
I6K16_RS19025	COG1702	phosphate starvation-inducible protein PhoH
I6K16_RS19035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K16_RS19080	COG0367	asparagine synthase
I6K16_RS19085	COG0647	UMP catabolic process
I6K16_RS19090	COG1846	Transcriptional regulator
I6K16_RS19090	COG1940	carbohydrate kinase activity
I6K16_RS19095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K16_RS19105	COG1263	PTS System
I6K16_RS19105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS19105	COG2190	(PTS) system
I6K16_RS19130	COG0735	belongs to the Fur family
I6K16_RS19140	COG0716	FMN binding
I6K16_RS19150	COG0596	Alpha beta hydrolase
I6K16_RS19155	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K16_RS19160	COG0033	Phosphoglucomutase
I6K16_RS19185	COG1982	Orn Lys Arg decarboxylase major
I6K16_RS19195	COG0745	RESPONSE REGULATOR receiver
I6K16_RS19200	COG2205	protein histidine kinase activity
I6K16_RS19250	COG3209	COG3209 Rhs family protein
I6K16_RS19270	COG3209	COG3209 Rhs family protein
I6K16_RS19285	COG5433	transposase activity
I6K16_RS19310	COG3272	Protein of unknown function (DUF1722)
I6K16_RS19315	COG0415	Belongs to the DNA photolyase family
I6K16_RS19325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K16_RS19330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K16_RS19335	COG1984	allophanate hydrolase subunit 2
I6K16_RS19345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K16_RS19350	COG3180	Ammonia monooxygenase
I6K16_RS19355	COG3539	Fimbrial protein
I6K16_RS19360	COG3121	Chaperone
I6K16_RS19365	COG3188	usher protein
I6K16_RS19370	COG3539	Fimbrial protein
I6K16_RS19375	COG0372	Belongs to the citrate synthase family
I6K16_RS19385	COG2009	succinate dehydrogenase
I6K16_RS19390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K16_RS19395	COG1053	succinate dehydrogenase
I6K16_RS19400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K16_RS19405	COG0567	Dehydrogenase, E1 component
I6K16_RS19410	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K16_RS19420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K16_RS19430	COG1271	oxidase subunit
I6K16_RS19435	COG1294	oxidase, subunit
I6K16_RS19440	COG4890	Cyd operon protein YbgT
I6K16_RS19445	COG3790	cyd operon protein YbgE
I6K16_RS19450	COG0824	Thioesterase
I6K16_RS19455	COG0811	peptide transport
I6K16_RS19460	COG0848	biopolymer transport protein
I6K16_RS19465	COG3064	Membrane
I6K16_RS19475	COG2885	chlorophyll binding
I6K16_RS19480	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K16_RS19525	COG3201	nicotinamide mononucleotide transporter
I6K16_RS19530	COG1230	cation diffusion facilitator family transporter
I6K16_RS19540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K16_RS19550	COG2017	converts alpha-aldose to the beta-anomer
I6K16_RS19560	COG1085	galactose-1-phosphate uridylyltransferase
I6K16_RS19565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K16_RS19570	COG1119	ATPase activity
I6K16_RS19575	COG2005	Transcriptional regulator
I6K16_RS19575	COG3585	molybdate ion transport
I6K16_RS19585	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K16_RS19590	COG4149	molybdate abc transporter
I6K16_RS19600	COG0561	phosphatase activity
I6K16_RS19610	COG0583	DNA-binding transcription factor activity
I6K16_RS19615	COG2828	Protein conserved in bacteria
I6K16_RS19620	COG0471	metal ion transport
I6K16_RS19625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K16_RS19630	COG4677	pectinesterase activity
I6K16_RS19635	COG0582	viral genome integration into host DNA
I6K16_RS19805	COG3772	lysozyme
I6K16_RS19825	COG4220	transposase activity
I6K16_RS19845	COG1030	water channel activity
I6K16_RS19895	COG1196	nuclear chromosome segregation
I6K16_RS19930	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS19935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K16_RS19945	COG2207	Transcriptional regulator
I6K16_RS19960	COG1881	PFAM PEBP family protein
I6K16_RS19965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K16_RS19980	COG2226	methyltransferase
I6K16_RS19985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K16_RS19995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K16_RS20005	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K16_RS20015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K16_RS20020	COG0314	molybdopterin synthase activity
I6K16_RS20025	COG0670	Belongs to the BI1 family
I6K16_RS20030	COG0670	Belongs to the BI1 family
I6K16_RS20035	COG0392	lysyltransferase activity
I6K16_RS20040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K16_RS20045	COG3568	Endonuclease Exonuclease Phosphatase
I6K16_RS20055	COG0842	Transport permease protein
I6K16_RS20060	COG0842	Transport permease protein
I6K16_RS20065	COG1131	(ABC) transporter
I6K16_RS20075	COG1309	transcriptional regulator
I6K16_RS20080	COG0513	Belongs to the DEAD box helicase family
I6K16_RS20090	COG1199	ATP-dependent helicase activity
I6K16_RS20095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K16_RS20100	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K16_RS20110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K16_RS20135	COG0668	transmembrane transport
I6K16_RS20140	COG1126	abc transporter atp-binding protein
I6K16_RS20145	COG0765	amino acid transport
I6K16_RS20150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS20160	COG5006	permease, DMT superfamily
I6K16_RS20170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K16_RS20175	COG2194	sulfuric ester hydrolase activity
I6K16_RS20185	COG1321	iron dependent repressor
I6K16_RS20190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K16_RS20195	COG1376	ErfK ybiS ycfS ynhG family protein
I6K16_RS20200	COG0488	(ABC) transporter
I6K16_RS20210	COG0561	phosphatase activity
I6K16_RS20215	COG1882	Formate acetyltransferase
I6K16_RS20220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K16_RS20225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K16_RS20230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K16_RS20235	COG0303	'Molybdopterin
I6K16_RS20240	COG1446	asparaginase
I6K16_RS20270	COG2199	diguanylate cyclase activity
I6K16_RS20295	COG2133	pyrroloquinoline quinone binding
I6K16_RS20300	COG0625	glutathione transferase activity
I6K16_RS20305	COG1686	Belongs to the peptidase S11 family
I6K16_RS20310	COG1349	DNA-binding transcription factor activity
I6K16_RS20315	COG0671	phosphoesterase, PA-phosphatase related
I6K16_RS20320	COG2814	Major facilitator Superfamily
I6K16_RS20330	COG0561	phosphatase activity
I6K16_RS20335	COG0738	Major facilitator superfamily
I6K16_RS20340	COG3226	Transcriptional regulator
I6K16_RS20355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K16_RS20365	COG0778	Nitroreductase
I6K16_RS20380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K16_RS20385	COG3842	ATPase activity
I6K16_RS20390	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K16_RS20395	COG1177	transmembrane transport
I6K16_RS20410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS20415	COG4160	amino acid transport
I6K16_RS20420	COG4215	(ABC) transporter
I6K16_RS20425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K16_RS20430	COG1126	abc transporter atp-binding protein
I6K16_RS20445	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K16_RS20450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K16_RS20455	COG0702	epimerase
I6K16_RS20460	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K16_RS20465	COG0028	Belongs to the TPP enzyme family
I6K16_RS20470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K16_RS20480	COG2431	L-lysine efflux transmembrane transporter activity
I6K16_RS20485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K16_RS20490	COG3593	DNA synthesis involved in DNA repair
I6K16_RS20495	COG2990	Protein conserved in bacteria
I6K16_RS20500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS20510	COG1278	Cold shock
I6K16_RS20520	COG0542	response to heat
I6K16_RS20540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K16_RS20545	COG4988	ABC transporter
I6K16_RS20550	COG0492	ferredoxin-NADP+ reductase activity
I6K16_RS20555	COG1522	sequence-specific DNA binding
I6K16_RS20570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K16_RS20580	COG0243	molybdopterin cofactor binding
I6K16_RS20585	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS20590	COG3302	dmso reductase anchor subunit
I6K16_RS20595	COG1335	isochorismatase
I6K16_RS20605	COG0531	amino acid
I6K16_RS20615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K16_RS20620	COG4974	Belongs to the 'phage' integrase family
I6K16_RS20680	COG4695	Portal protein
I6K16_RS20795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K16_RS20825	COG1484	DNA-dependent DNA replication
I6K16_RS20830	COG4584	PFAM Integrase catalytic
I6K16_RS20855	COG1882	Formate acetyltransferase
I6K16_RS20860	COG2116	formate transmembrane transporter activity
I6K16_RS20865	COG1944	ATP diphosphatase activity
I6K16_RS20870	COG2323	membrane
I6K16_RS20885	COG0501	Belongs to the peptidase M48B family
I6K16_RS20895	COG0539	negative regulation of cytoplasmic translation
I6K16_RS20905	COG0658	competence protein
I6K16_RS20905	COG2333	competence protein COMEC
I6K16_RS20920	COG3214	Protein conserved in bacteria
I6K16_RS20935	COG3173	Aminoglycoside phosphotransferase
I6K16_RS20940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K16_RS20945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K16_RS20955	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K16_RS20970	COG2989	Protein conserved in bacteria
I6K16_RS20975	COG3108	Peptidase M15
I6K16_RS20980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K16_RS20985	COG1448	Aminotransferase
I6K16_RS21005	COG0308	aminopeptidase N
I6K16_RS21015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K16_RS21025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K16_RS21030	COG0431	NADPH-dependent FMN reductase
I6K16_RS21045	COG3217	Mosc domain protein beta barrel domain protein
I6K16_RS21045	COG0633	Ferredoxin
I6K16_RS21055	COG0488	(ABC) transporter
I6K16_RS21060	COG2995	paraquat-inducible protein a
I6K16_RS21065	COG3008	intermembrane lipid transfer
I6K16_RS21065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K16_RS21070	COG3009	Protein conserved in bacteria
I6K16_RS21075	COG3130	regulation of translation
I6K16_RS21085	COG1067	ATP-dependent peptidase activity
I6K16_RS21095	COG2885	chlorophyll binding
I6K16_RS21095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K16_RS21105	COG3070	regulator of competence-specific genes
I6K16_RS21110	COG1289	transmembrane transporter activity
I6K16_RS21115	COG3304	Inner membrane component domain
I6K16_RS21120	COG0210	DNA helicase
I6K16_RS21135	COG1832	CoA-binding protein
I6K16_RS21150	COG1254	Belongs to the acylphosphatase family
I6K16_RS21155	COG2920	part of a sulfur-relay system
I6K16_RS21160	COG0670	Belongs to the BI1 family
I6K16_RS21170	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K16_RS21175	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K16_RS21180	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6K16_RS21185	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K16_RS21190	COG1999	signal sequence binding
I6K16_RS21195	COG1773	rubredoxin
I6K16_RS21200	COG1271	oxidase subunit
I6K16_RS21205	COG1294	oxidase, subunit
I6K16_RS21220	COG0489	protein tyrosine kinase activity
I6K16_RS21220	COG3206	protein involved in exopolysaccharide biosynthesis
I6K16_RS21225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K16_RS21230	COG1596	polysaccharide export
I6K16_RS21235	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K16_RS21255	COG1278	Cold shock
I6K16_RS21260	COG1278	Cold shock
I6K16_RS21280	COG0348	domain, Protein
I6K16_RS21285	COG0784	Response regulator, receiver
I6K16_RS21285	COG2198	Histidine kinase
I6K16_RS21285	COG2205	protein histidine kinase activity
I6K16_RS21290	COG1879	ABC-type sugar transport system periplasmic component
I6K16_RS21295	COG0745	RESPONSE REGULATOR receiver
I6K16_RS21300	COG3005	denitrification pathway
I6K16_RS21305	COG0243	molybdopterin cofactor binding
I6K16_RS21340	COG3729	General stress protein
I6K16_RS21345	COG2233	PERMEase
I6K16_RS21380	COG1309	transcriptional regulator
I6K16_RS21385	COG0506	proline dehydrogenase activity
I6K16_RS21385	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K16_RS21385	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K16_RS21395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K16_RS21405	COG2822	iron ion transport
I6K16_RS21415	COG1702	phosphate starvation-inducible protein PhoH
I6K16_RS21455	COG3381	protein complex oligomerization
I6K16_RS21465	COG1462	curli production assembly transport component CsgG
I6K16_RS21480	COG2197	response regulator
I6K16_RS21505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K16_RS21510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K16_RS21525	COG2943	transferase activity, transferring hexosyl groups
I6K16_RS21530	COG5645	(Lipo)protein
I6K16_RS21545	COG1560	Kdo2-lipid A biosynthetic process
I6K16_RS21555	COG2353	YceI-like domain
I6K16_RS21560	COG3038	cytochrome b561
I6K16_RS21595	COG2999	glutathione oxidoreductase activity
I6K16_RS21605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K16_RS21615	COG0673	inositol 2-dehydrogenase activity
I6K16_RS21620	COG0728	peptidoglycan biosynthetic process
I6K16_RS21625	COG3418	PFAM FlgN family protein
I6K16_RS21630	COG2747	anti-sigma28 factor FlgM
I6K16_RS21635	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6K16_RS21640	COG1815	bacterial-type flagellum-dependent cell motility
I6K16_RS21645	COG1558	bacterial-type flagellum-dependent cell motility
I6K16_RS21650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6K16_RS21655	COG1749	Flagellar hook protein flgE
I6K16_RS21660	COG4787	bacterial-type flagellum-dependent cell motility
I6K16_RS21665	COG4786	Flagellar basal body rod
I6K16_RS21680	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K16_RS21680	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6K16_RS21685	COG1256	bacterial-type flagellum assembly
I6K16_RS21690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K16_RS21705	COG1530	ribonuclease E activity
I6K16_RS21710	COG0564	pseudouridine synthase activity
I6K16_RS21715	COG0424	maF-like protein
I6K16_RS21720	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K16_RS21740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K16_RS21745	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS21755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K16_RS21765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K16_RS21770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K16_RS21780	COG0470	DNA polymerase III
I6K16_RS21785	COG0084	hydrolase, TatD family'
I6K16_RS21790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K16_RS21790	COG1263	PTS System
I6K16_RS21795	COG4773	Receptor
I6K16_RS21800	COG0537	adenosine 5'-monophosphoramidase activity
I6K16_RS21805	COG5633	Lipoprotein
I6K16_RS21810	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6K16_RS21830	COG1252	NADH dehydrogenase
I6K16_RS21835	COG3134	Outer membrane lipoprotein
I6K16_RS21840	COG1309	transcriptional regulator
I6K16_RS21850	COG1388	LysM domain
I6K16_RS21850	COG1376	ErfK ybiS ycfS ynhG family protein
I6K16_RS21855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K16_RS21860	COG4763	Acyl-transferase
I6K16_RS21865	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K16_RS21875	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K16_RS21885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K16_RS21890	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K16_RS21905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K16_RS21910	COG1177	transmembrane transport
I6K16_RS21920	COG3842	ATPase activity
I6K16_RS21930	COG2850	peptidyl-arginine hydroxylation
I6K16_RS21935	COG2205	protein histidine kinase activity
I6K16_RS21945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K16_RS21965	COG1187	pseudouridine synthase activity
I6K16_RS21970	COG0538	isocitrate dehydrogenase activity
I6K16_RS21985	COG5562	phage envelope protein
I6K16_RS21990	COG0789	Transcriptional regulator
I6K16_RS21995	COG2200	EAL domain
I6K16_RS22020	COG2200	EAL domain
I6K16_RS22070	COG2894	cell division
I6K16_RS22095	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K16_RS22110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K16_RS22115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K16_RS22125	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6K16_RS22135	COG2719	SpoVR family
I6K16_RS22145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K16_RS22155	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K16_RS22165	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K16_RS22180	COG0157	Belongs to the NadC ModD family
I6K16_RS22185	COG0500	methyltransferase
I6K16_RS22190	COG1120	ATPase activity
I6K16_RS22195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K16_RS22200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K16_RS22210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K16_RS22210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K16_RS22210	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K16_RS22215	COG1461	Dihydroxyacetone kinase
I6K16_RS22220	COG2376	Dihydroxyacetone kinase
I6K16_RS22225	COG3284	Transcriptional regulator
I6K16_RS22235	COG0012	GTP binding
I6K16_RS22250	COG0659	secondary active sulfate transmembrane transporter activity
I6K16_RS22255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K16_RS22280	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K16_RS22285	COG3094	Invasion gene expression up-regulator, SirB
I6K16_RS22290	COG2912	Transglutaminase-like superfamily
I6K16_RS22305	COG0387	Pfam Sodium calcium exchanger
I6K16_RS22310	COG4572	Cation transport regulator
I6K16_RS22315	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K16_RS22320	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K16_RS22325	COG4932	domain protein
I6K16_RS22330	COG2197	response regulator
I6K16_RS22335	COG3850	Histidine kinase
I6K16_RS22340	COG2223	nitrite transmembrane transporter activity
I6K16_RS22345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K16_RS22350	COG1140	nitrate reductase beta subunit
I6K16_RS22355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K16_RS22360	COG2181	nitrate reductase activity
I6K16_RS22380	COG0788	formyltetrahydrofolate deformylase activity
I6K16_RS22390	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K16_RS22395	COG0745	RESPONSE REGULATOR receiver
I6K16_RS22400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K16_RS22410	COG1435	thymidine kinase activity
I6K16_RS22415	COG1454	alcohol dehydrogenase
I6K16_RS22415	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS22420	COG2095	MarC family integral membrane protein
I6K16_RS22430	COG4166	transmembrane transport
I6K16_RS22435	COG0601	transmembrane transport
I6K16_RS22440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K16_RS22445	COG0444	Belongs to the ABC transporter superfamily
I6K16_RS22450	COG4608	Belongs to the ABC transporter superfamily
I6K16_RS22470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K16_RS22475	COG2350	Protein conserved in bacteria
I6K16_RS22480	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K16_RS22485	COG1607	acyl-coa hydrolase
I6K16_RS22505	COG3047	cAMP biosynthetic process
I6K16_RS22510	COG0582	viral genome integration into host DNA
I6K16_RS22520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K16_RS22570	COG1846	Transcriptional regulator
I6K16_RS22580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K16_RS22610	COG1403	HNH endonuclease
I6K16_RS22615	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K16_RS22635	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K16_RS22675	COG3772	lysozyme
I6K16_RS22705	COG4220	transposase activity
I6K16_RS22740	COG0582	viral genome integration into host DNA
I6K16_RS22910	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K16_RS22915	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K16_RS22920	COG0500	methyltransferase
I6K16_RS22940	COG3685	Protein conserved in bacteria
I6K16_RS22945	COG3685	Protein conserved in bacteria
I6K16_RS22950	COG3729	General stress protein
I6K16_RS22965	COG0134	indole-3-glycerol-phosphate synthase activity
I6K16_RS22965	COG0135	phosphoribosylanthranilate isomerase activity
I6K16_RS22970	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K16_RS22970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K16_RS22975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K16_RS22985	COG0613	PHP domain protein
I6K16_RS22990	COG0009	L-threonylcarbamoyladenylate synthase
I6K16_RS22995	COG4907	membrane protein (DUF2207)
I6K16_RS23000	COG1187	pseudouridine synthase activity
I6K16_RS23015	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K16_RS23020	COG1028	Short-chain dehydrogenase reductase Sdr
I6K16_RS23025	COG0616	signal peptide processing
I6K16_RS23035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K16_RS23040	COG0583	DNA-binding transcription factor activity
I6K16_RS23060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K16_RS23070	COG0671	phosphoesterase, PA-phosphatase related
I6K16_RS23075	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K16_RS23080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K16_RS23090	COG0023	Translation Initiation Factor
I6K16_RS23100	COG1349	DNA-binding transcription factor activity
I6K16_RS23110	COG5001	Diguanylate cyclase
I6K16_RS23125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K16_RS23125	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K16_RS23130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K16_RS23140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K16_RS23145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K16_RS23155	COG2814	Major facilitator Superfamily
I6K16_RS23160	COG4172	Belongs to the ABC transporter superfamily
I6K16_RS23165	COG4172	Belongs to the ABC transporter superfamily
I6K16_RS23170	COG4171	peptide transport system, permease
I6K16_RS23175	COG4168	peptide transport system, permease
I6K16_RS23180	COG4166	transmembrane transport
I6K16_RS23190	COG0531	amino acid
I6K16_RS23200	COG0174	glutamine synthetase
I6K16_RS23205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K16_RS23210	COG1917	Cupin 2, conserved barrel domain protein
I6K16_RS23210	COG1396	sequence-specific DNA binding
I6K16_RS23215	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS23220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K16_RS23225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K16_RS23230	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K16_RS23235	COG1842	Phage shock protein A
I6K16_RS23245	COG1983	PspC domain protein
I6K16_RS23255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K16_RS23260	COG0366	Alpha amylase catalytic
I6K16_RS23265	COG1653	transport
I6K16_RS23270	COG1175	transmembrane transport
I6K16_RS23275	COG0395	ABC-type sugar transport system, permease component
I6K16_RS23280	COG1063	alcohol dehydrogenase
I6K16_RS23285	COG1082	Xylose isomerase domain protein TIM barrel
I6K16_RS23290	COG0673	inositol 2-dehydrogenase activity
I6K16_RS23295	COG1554	hydrolase, family 65, central catalytic
I6K16_RS23300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K16_RS23315	COG1609	Transcriptional regulator
I6K16_RS23320	COG3106	COG3106 Predicted ATPase
I6K16_RS23330	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6K16_RS23335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K16_RS23340	COG4948	Mandelate Racemase Muconate Lactonizing
I6K16_RS23345	COG2866	Carboxypeptidase
I6K16_RS23350	COG0702	epimerase
I6K16_RS23355	COG1073	alpha beta
I6K16_RS23360	COG0583	DNA-binding transcription factor activity
I6K16_RS23365	COG4166	transmembrane transport
I6K16_RS23370	COG0668	transmembrane transport
I6K16_RS23375	COG3182	Iron-regulated membrane protein
I6K16_RS23380	COG0589	response to stress
I6K16_RS23385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K16_RS23390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K16_RS23400	COG2207	Transcriptional regulator
I6K16_RS23415	COG2840	Smr protein MutS2
I6K16_RS23420	COG3706	GGDEF domain
I6K16_RS23430	COG0513	Belongs to the DEAD box helicase family
I6K16_RS23440	COG0589	response to stress
I6K16_RS23445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K16_RS23450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K16_RS23450	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K16_RS23450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K16_RS23450	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K16_RS23455	COG3042	response to heat
I6K16_RS23460	COG3187	Heat shock protein
I6K16_RS23465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K16_RS23470	COG2911	Protein conserved in bacteria
I6K16_RS23480	COG3784	Protein of unknown function (DUF1318)
I6K16_RS23485	COG2207	Transcriptional regulator
I6K16_RS23490	COG3327	negative regulation of DNA-templated transcription, initiation
I6K16_RS23495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K16_RS23500	COG0667	Aldo Keto reductase
I6K16_RS23515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K16_RS23520	COG4589	Belongs to the CDS family
I6K16_RS23525	COG2267	carboxylic ester hydrolase activity
I6K16_RS23530	COG2453	phosphatase
I6K16_RS23530	COG0671	phosphoesterase, PA-phosphatase related
I6K16_RS23540	COG1643	Atp-dependent helicase
I6K16_RS23545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K16_RS23550	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS23555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K16_RS23560	COG3038	cytochrome b561
I6K16_RS23575	COG0840	transmembrane signaling receptor activity
I6K16_RS23580	COG0583	DNA-binding transcription factor activity
I6K16_RS23585	COG5383	Protein conserved in bacteria
I6K16_RS23595	COG2841	Protein conserved in bacteria
I6K16_RS23600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K16_RS23605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K16_RS23610	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K16_RS23615	COG0500	methyltransferase
I6K16_RS23625	COG3135	benzoate transporter
I6K16_RS23630	COG1396	sequence-specific DNA binding
I6K16_RS23635	COG0826	peptidase U32
I6K16_RS23645	COG1724	mRNA binding
I6K16_RS23650	COG1598	PFAM Uncharacterised protein family UPF0150
I6K16_RS23655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K16_RS23660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K16_RS23670	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K16_RS23675	COG1177	transmembrane transport
I6K16_RS23700	COG3238	Protein conserved in bacteria
I6K16_RS23705	COG1247	-acetyltransferase
I6K16_RS23710	COG2130	NADP-dependent
I6K16_RS23715	COG1802	Transcriptional regulator
I6K16_RS23720	COG4772	TonB-dependent receptor
I6K16_RS23725	COG3391	amine dehydrogenase activity
I6K16_RS23730	COG1113	amino acid transport
I6K16_RS23775	COG2203	Gaf domain
I6K16_RS23775	COG5001	Diguanylate cyclase
I6K16_RS23775	COG3706	GGDEF domain
I6K16_RS23775	COG4251	negative regulation of phosphorylation
I6K16_RS23780	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K16_RS23790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K16_RS23795	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K16_RS23800	COG0384	phenazine biosynthesis protein PhzF
I6K16_RS23805	COG2181	nitrate reductase activity
I6K16_RS23810	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K16_RS23815	COG1140	nitrate reductase beta subunit
I6K16_RS23820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K16_RS23825	COG2223	nitrite transmembrane transporter activity
I6K16_RS23830	COG0697	spore germination
I6K16_RS23840	COG0437	4 iron, 4 sulfur cluster binding
I6K16_RS23845	COG2864	formate dehydrogenase
I6K16_RS23855	COG1649	PFAM Uncharacterised BCR, COG1649
I6K16_RS23870	COG2200	EAL domain
I6K16_RS23870	COG2202	Pas domain
I6K16_RS23870	COG2199	diguanylate cyclase activity
I6K16_RS23875	COG1764	response to oxidative stress
I6K16_RS23895	COG1064	alcohol dehydrogenase
I6K16_RS23900	COG3093	addiction module antidote protein HigA
I6K16_RS23910	COG0531	amino acid
I6K16_RS23915	COG0076	glutamate decarboxylase activity
I6K16_RS23920	COG0612	Peptidase, M16
I6K16_RS23925	COG4771	TonB-dependent receptor
I6K16_RS23930	COG4178	(ABC) transporter
I6K16_RS23940	COG0641	radical SAM
I6K16_RS23945	COG3119	arylsulfatase activity
I6K16_RS23950	COG2207	Transcriptional regulator
I6K16_RS23960	COG0243	molybdopterin cofactor binding
I6K16_RS23965	COG3539	Fimbrial protein
I6K16_RS23970	COG3539	Fimbrial protein
I6K16_RS23975	COG3539	Fimbrial protein
I6K16_RS23980	COG3188	usher protein
I6K16_RS23990	COG3539	Fimbrial protein
I6K16_RS24000	COG3550	peptidyl-serine autophosphorylation
I6K16_RS24005	COG1396	sequence-specific DNA binding
I6K16_RS24060	COG3781	membrane
I6K16_RS24070	COG2199	diguanylate cyclase activity
I6K16_RS24080	COG2066	Belongs to the glutaminase family
I6K16_RS24085	COG1012	belongs to the aldehyde dehydrogenase family
I6K16_RS24090	COG0583	DNA-binding transcription factor activity
I6K16_RS24110	COG1846	Transcriptional regulator
I6K16_RS24115	COG4977	sequence-specific DNA binding
I6K16_RS24125	COG0697	spore germination
I6K16_RS24130	COG2814	Major facilitator Superfamily
I6K16_RS24140	COG3706	GGDEF domain
I6K16_RS24145	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K16_RS24150	COG0339	signal peptide processing
I6K16_RS24155	COG4221	oxidoreductase activity
I6K16_RS24160	COG1802	Transcriptional regulator
I6K16_RS24170	COG0246	Mannitol dehydrogenase
I6K16_RS24190	COG4571	Outer membrane protease
I6K16_RS24245	COG1121	(ABC) transporter
I6K16_RS24250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K16_RS24255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K16_RS24270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6K16_RS24350	COG3385	transposase activity
I6K16_RS24405	COG1475	DNA binding
I6K16_RS24565	COG4584	PFAM Integrase catalytic
I6K16_RS24570	COG1484	DNA-dependent DNA replication
I6K16_RS24730	COG2072	flavoprotein involved in K transport
I6K16_RS24740	COG0673	inositol 2-dehydrogenase activity
I6K16_RS24750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K16_RS24865	COG2819	hydrolase of the alpha beta superfamily
I6K16_RS24870	COG2382	esterase
I6K16_RS24930	COG1538	Outer membrane efflux protein
I6K16_RS24940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family