locus-tag	class	description
I6K17_RS00045	COG2805	Type II/IV secretion system protein
I6K17_RS00395	COG5290	Psort location Cytoplasmic, score
I6K17_RS00595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K17_RS00610	COG0741	lytic transglycosylase activity
I6K17_RS00620	COG0651	ATP synthesis coupled electron transport
I6K17_RS00625	COG0650	Formate hydrogenlyase subunit 4
I6K17_RS00630	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K17_RS00630	COG3261	NADH dehydrogenase
I6K17_RS00635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K17_RS00640	COG3260	NADH ubiquinone oxidoreductase 20
I6K17_RS00650	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K17_RS00655	COG2723	6-phospho-beta-galactosidase activity
I6K17_RS00660	COG1263	PTS System
I6K17_RS00660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS00665	COG1609	Transcriptional regulator
I6K17_RS00670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS00675	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K17_RS00695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K17_RS00695	COG0517	IMP dehydrogenase activity
I6K17_RS00700	COG1349	DNA-binding transcription factor activity
I6K17_RS00705	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS00720	COG3732	PTS system glucitol sorbitol-specific
I6K17_RS00725	COG3730	PTS system glucitol sorbitol-specific
I6K17_RS00730	COG2951	lytic endotransglycosylase activity
I6K17_RS00735	COG1546	Belongs to the CinA family
I6K17_RS00755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K17_RS00785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K17_RS00790	COG1238	metal cluster binding
I6K17_RS00805	COG2814	Major facilitator Superfamily
I6K17_RS00810	COG1566	PFAM secretion protein HlyD family protein
I6K17_RS00815	COG1846	Transcriptional regulator
I6K17_RS00825	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K17_RS00830	COG2814	Major facilitator Superfamily
I6K17_RS00835	COG2113	Glycine betaine
I6K17_RS00840	COG4176	ABC-type proline glycine betaine transport system permease component
I6K17_RS00845	COG4175	Glycine betaine
I6K17_RS00850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K17_RS00855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K17_RS00865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K17_RS00870	COG4575	ribosome binding
I6K17_RS00885	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K17_RS00890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K17_RS00895	COG0640	Transcriptional regulator
I6K17_RS00900	COG0401	homolog of Blt101
I6K17_RS00905	COG1652	LysM domain
I6K17_RS00910	COG1802	Transcriptional regulator
I6K17_RS00915	COG1113	amino acid transport
I6K17_RS00920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K17_RS00925	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS00930	COG0579	oxidoreductase
I6K17_RS00945	COG4974	Belongs to the 'phage' integrase family
I6K17_RS00980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K17_RS01010	COG4695	Portal protein
I6K17_RS01100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS01115	COG3778	Protein conserved in bacteria
I6K17_RS01120	COG3299	homolog of phage Mu protein gp47
I6K17_RS01140	COG4228	DNA circulation
I6K17_RS01160	COG4386	tail sheath protein
I6K17_RS01205	COG4695	Portal protein
I6K17_RS01215	COG1802	Transcriptional regulator
I6K17_RS01215	COG4626	Terminase
I6K17_RS01240	COG3179	chitinase
I6K17_RS01265	COG0484	heat shock protein binding
I6K17_RS01270	COG1403	HNH endonuclease
I6K17_RS01280	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K17_RS01290	COG4725	Belongs to the MT-A70-like family
I6K17_RS01300	COG1846	Transcriptional regulator
I6K17_RS01315	COG4197	protein conserved in bacteria, prophage-related
I6K17_RS01320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K17_RS01340	COG5532	Uncharacterized conserved protein (DUF2303)
I6K17_RS01345	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K17_RS01360	COG0582	viral genome integration into host DNA
I6K17_RS01435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K17_RS01445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS01460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K17_RS01490	COG2867	negative regulation of translational initiation
I6K17_RS01500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K17_RS01505	COG0497	DNA recombination
I6K17_RS01520	COG4536	flavin adenine dinucleotide binding
I6K17_RS01525	COG4137	Cytochrome C assembly protein
I6K17_RS01530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K17_RS01555	COG2885	chlorophyll binding
I6K17_RS01560	COG2199	diguanylate cyclase activity
I6K17_RS01575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K17_RS01580	COG0287	Prephenate dehydrogenase
I6K17_RS01580	COG1605	Chorismate mutase
I6K17_RS01585	COG1605	Chorismate mutase
I6K17_RS01585	COG0077	Prephenate dehydratase
I6K17_RS01595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K17_RS01605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K17_RS01610	COG0564	pseudouridine synthase activity
I6K17_RS01620	COG0542	response to heat
I6K17_RS01645	COG0477	Major facilitator Superfamily
I6K17_RS01650	COG5544	Lipoprotein
I6K17_RS01655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K17_RS01660	COG1042	CoA-binding domain protein
I6K17_RS01660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K17_RS01660	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K17_RS01665	COG3148	PFAM DTW domain containing protein
I6K17_RS01670	COG3118	belongs to the thioredoxin family
I6K17_RS01675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K17_RS01695	COG0583	DNA-binding transcription factor activity
I6K17_RS01700	COG0513	Belongs to the DEAD box helicase family
I6K17_RS01710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K17_RS01720	COG1595	DNA-templated transcription, initiation
I6K17_RS01725	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K17_RS01730	COG3026	antisigma factor binding
I6K17_RS01735	COG3086	response to oxidative stress
I6K17_RS01745	COG0681	Belongs to the peptidase S26 family
I6K17_RS01765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K17_RS01780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS01785	COG1737	Transcriptional regulator
I6K17_RS01790	COG0560	Phosphoserine phosphatase
I6K17_RS01805	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K17_RS01805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K17_RS01810	COG2205	protein histidine kinase activity
I6K17_RS01815	COG3170	Tfp pilus assembly protein FimV
I6K17_RS01820	COG2204	response regulator
I6K17_RS01825	COG0347	Belongs to the P(II) protein family
I6K17_RS01830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K17_RS01830	COG1017	nitric oxide dioxygenase activity
I6K17_RS01840	COG1940	carbohydrate kinase activity
I6K17_RS01845	COG0457	Tetratricopeptide repeat
I6K17_RS01850	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS01855	COG1129	ABC transporter
I6K17_RS01860	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS01865	COG1063	alcohol dehydrogenase
I6K17_RS01870	COG2017	converts alpha-aldose to the beta-anomer
I6K17_RS01875	COG2259	Doxx family
I6K17_RS01900	COG4638	Rieske (2fe-2S)
I6K17_RS01905	COG0583	DNA-binding transcription factor activity
I6K17_RS01910	COG2814	Major facilitator Superfamily
I6K17_RS01915	COG3711	transcriptional antiterminator
I6K17_RS01920	COG1073	alpha beta
I6K17_RS01925	COG0483	inositol monophosphate 1-phosphatase activity
I6K17_RS01945	COG0822	iron-sulfur transferase activity
I6K17_RS01965	COG0633	Ferredoxin
I6K17_RS01970	COG2975	iron-sulfur cluster assembly
I6K17_RS01985	COG2897	thiosulfate sulfurtransferase activity
I6K17_RS01990	COG2373	Large extracellular alpha-helical protein
I6K17_RS01995	COG4953	penicillin-binding protein 1C
I6K17_RS02025	COG2976	Protein conserved in bacteria
I6K17_RS02040	COG1645	bacterial-type flagellum-dependent swarming motility
I6K17_RS02065	COG0517	IMP dehydrogenase activity
I6K17_RS02065	COG0516	GMP reductase activity
I6K17_RS02080	COG3133	Outer membrane lipoprotein
I6K17_RS02095	COG2200	EAL domain
I6K17_RS02100	COG0248	Ppx GppA phosphatase
I6K17_RS02105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6K17_RS02110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K17_RS02125	COG2233	PERMEase
I6K17_RS02135	COG1393	Belongs to the ArsC family
I6K17_RS02140	COG4783	chaperone-mediated protein folding
I6K17_RS02145	COG0628	permease
I6K17_RS02150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K17_RS02155	COG2716	regulation of RNA biosynthetic process
I6K17_RS02165	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K17_RS02185	COG2321	neutral zinc metallopeptidase
I6K17_RS02195	COG0400	carboxylic ester hydrolase activity
I6K17_RS02210	COG1393	Belongs to the ArsC family
I6K17_RS02220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K17_RS02225	COG3850	Histidine kinase
I6K17_RS02230	COG0493	'glutamate synthase
I6K17_RS02230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS02240	COG5342	invasion associated locus B
I6K17_RS02245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K17_RS02250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K17_RS02255	COG0280	phosphate acetyltransferase
I6K17_RS02255	COG0281	malic enzyme
I6K17_RS02260	COG4810	utilization protein
I6K17_RS02265	COG4917	ethanolamine utilization protein
I6K17_RS02270	COG4766	ethanolamine catabolic process
I6K17_RS02275	COG4812	Cobalamin adenosyltransferase
I6K17_RS02280	COG0280	phosphate acetyltransferase
I6K17_RS02285	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K17_RS02290	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K17_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS02300	COG4820	ethanolamine utilization protein (EutJ)
I6K17_RS02305	COG1454	alcohol dehydrogenase
I6K17_RS02310	COG3192	ethanolamine utilization protein
I6K17_RS02315	COG4819	ethanolamine utilization protein
I6K17_RS02320	COG4303	Ethanolamine ammonia lyase large subunit
I6K17_RS02330	COG4816	utilization protein
I6K17_RS02335	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K17_RS02340	COG2207	Transcriptional regulator
I6K17_RS02350	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K17_RS02370	COG2837	iron assimilation
I6K17_RS02375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K17_RS02380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS02380	COG1263	PTS System
I6K17_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS02400	COG4150	thiosulfate binding
I6K17_RS02405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K17_RS02410	COG4208	sulfate ABC transporter
I6K17_RS02415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K17_RS02420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K17_RS02435	COG2190	(PTS) system
I6K17_RS02440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K17_RS02445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS02450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K17_RS02470	COG3530	Putative quorum-sensing-regulated virulence factor
I6K17_RS02475	COG0385	Bile acid
I6K17_RS02480	COG0583	DNA-binding transcription factor activity
I6K17_RS02490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K17_RS02495	COG2211	Major facilitator Superfamily
I6K17_RS02505	COG0583	DNA-binding transcription factor activity
I6K17_RS02535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K17_RS02540	COG3415	Transposase
I6K17_RS02545	COG3415	Transposase
I6K17_RS02560	COG2199	diguanylate cyclase activity
I6K17_RS02560	COG2200	EAL domain
I6K17_RS02565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K17_RS02590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS02595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS02600	COG0006	proline dipeptidase activity
I6K17_RS02605	COG1363	Peptidase, m42
I6K17_RS02610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS02610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS02610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K17_RS02615	COG2207	Transcriptional regulator
I6K17_RS02620	COG3279	Response regulator of the LytR AlgR family
I6K17_RS02625	COG3275	phosphorelay sensor kinase activity
I6K17_RS02630	COG0436	Aminotransferase
I6K17_RS02640	COG1560	Kdo2-lipid A biosynthetic process
I6K17_RS02665	COG0028	Belongs to the TPP enzyme family
I6K17_RS02670	COG0679	Auxin Efflux Carrier
I6K17_RS02675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K17_RS02680	COG0784	Response regulator, receiver
I6K17_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS02680	COG2198	Histidine kinase
I6K17_RS02680	COG2205	protein histidine kinase activity
I6K17_RS02685	COG2197	response regulator
I6K17_RS02690	COG1566	PFAM secretion protein HlyD family protein
I6K17_RS02695	COG0477	Major facilitator Superfamily
I6K17_RS02740	COG2116	formate transmembrane transporter activity
I6K17_RS02745	COG2853	Lipoprotein
I6K17_RS02750	COG2067	long-chain fatty acid transport protein
I6K17_RS02755	COG3691	Protein conserved in bacteria
I6K17_RS02770	COG2062	phosphohistidine phosphatase, SixA
I6K17_RS02775	COG3539	Fimbrial protein
I6K17_RS02780	COG3188	usher protein
I6K17_RS02785	COG3121	Chaperone
I6K17_RS02790	COG3539	Fimbrial protein
I6K17_RS02795	COG3539	Fimbrial protein
I6K17_RS02800	COG3539	Fimbrial protein
I6K17_RS02830	COG0730	response to heat
I6K17_RS02835	COG3101	peptidyl-lysine hydroxylation
I6K17_RS02850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K17_RS02855	COG2814	Major facilitator Superfamily
I6K17_RS02870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K17_RS02880	COG0586	Pfam SNARE associated Golgi protein
I6K17_RS02890	COG0285	dihydrofolate synthase activity
I6K17_RS02895	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K17_RS02900	COG1286	toxin biosynthetic process
I6K17_RS02905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K17_RS02910	COG0163	prenyltransferase activity
I6K17_RS02920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS02925	COG4215	(ABC) transporter
I6K17_RS02930	COG4160	amino acid transport
I6K17_RS02935	COG4598	ABC transporter
I6K17_RS02940	COG5464	transposase or invertase
I6K17_RS02945	COG1090	epimerase
I6K17_RS02950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K17_RS02955	COG0625	glutathione transferase activity
I6K17_RS02960	COG0625	glutathione transferase activity
I6K17_RS02965	COG0622	Phosphoesterase
I6K17_RS02970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K17_RS02975	COG1288	antiporter activity
I6K17_RS02980	COG0857	belongs to the CobB CobQ family
I6K17_RS02980	COG0280	phosphate acetyltransferase
I6K17_RS02985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K17_RS03000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K17_RS03005	COG0471	metal ion transport
I6K17_RS03005	COG0490	domain, Protein
I6K17_RS03015	COG0436	Aminotransferase
I6K17_RS03020	COG0583	DNA-binding transcription factor activity
I6K17_RS03040	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K17_RS03045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K17_RS03050	COG1034	ATP synthesis coupled electron transport
I6K17_RS03065	COG0839	Belongs to the complex I subunit 6 family
I6K17_RS03075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K17_RS03080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K17_RS03095	COG2234	aminopeptidase activity
I6K17_RS03110	COG2153	protein acetylation
I6K17_RS03115	COG4575	ribosome binding
I6K17_RS03120	COG1169	isochorismate synthase
I6K17_RS03135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K17_RS03140	COG1441	menaquinone biosynthetic process
I6K17_RS03145	COG0318	PFAM AMP-dependent synthetase and ligase
I6K17_RS03165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6K17_RS03215	COG2271	Major facilitator Superfamily
I6K17_RS03225	COG5464	transposase or invertase
I6K17_RS03230	COG0247	lactate metabolic process
I6K17_RS03240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K17_RS03245	COG2271	Major facilitator Superfamily
I6K17_RS03250	COG0584	glycerophosphoryl diester phosphodiesterase
I6K17_RS03255	COG3642	lipopolysaccharide core region biosynthetic process
I6K17_RS03260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K17_RS03265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K17_RS03270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K17_RS03275	COG3468	outer membrane autotransporter barrel domain protein
I6K17_RS03285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K17_RS03290	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6K17_RS03295	COG3234	Protein of unknown function (DUF1175)
I6K17_RS03300	COG2373	Large extracellular alpha-helical protein
I6K17_RS03305	COG5445	Predicted secreted protein (DUF2300)
I6K17_RS03310	COG4676	Protein conserved in bacteria
I6K17_RS03315	COG0183	Belongs to the thiolase family
I6K17_RS03320	COG2031	fatty acid transporter
I6K17_RS03325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K17_RS03330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K17_RS03335	COG2204	response regulator
I6K17_RS03340	COG3852	Histidine kinase
I6K17_RS03345	COG0784	Response regulator, receiver
I6K17_RS03345	COG2205	protein histidine kinase activity
I6K17_RS03350	COG2197	response regulator
I6K17_RS03355	COG0642	Histidine kinase
I6K17_RS03355	COG2198	Histidine kinase
I6K17_RS03360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K17_RS03365	COG1477	protein flavinylation
I6K17_RS03370	COG2169	Transcriptional regulator
I6K17_RS03370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K17_RS03375	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K17_RS03380	COG4615	Cyclic peptide transporter
I6K17_RS03395	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS03395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS03400	COG3062	negative regulation of establishment of protein localization
I6K17_RS03410	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS03415	COG0348	domain, Protein
I6K17_RS03420	COG3043	anaerobic respiration
I6K17_RS03425	COG3005	denitrification pathway
I6K17_RS03430	COG4133	protoheme IX ABC transporter activity
I6K17_RS03435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K17_RS03440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K17_RS03445	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K17_RS03455	COG1138	Cytochrome C-type biogenesis protein
I6K17_RS03460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K17_RS03465	COG4235	cytochrome complex assembly
I6K17_RS03465	COG3088	subunit of a heme lyase
I6K17_RS03470	COG2197	response regulator
I6K17_RS03485	COG3083	sulfuric ester hydrolase activity
I6K17_RS03505	COG1061	Type III restriction enzyme res subunit
I6K17_RS03510	COG1187	pseudouridine synthase activity
I6K17_RS03515	COG2814	Major facilitator Superfamily
I6K17_RS03525	COG4172	Belongs to the ABC transporter superfamily
I6K17_RS03530	COG4239	(ABC) transporter, permease
I6K17_RS03535	COG4174	ABC transporter (Permease)
I6K17_RS03540	COG4166	transmembrane transport
I6K17_RS03545	COG2200	EAL domain
I6K17_RS03550	COG0791	NLP P60 protein
I6K17_RS03555	COG0671	phosphoesterase, PA-phosphatase related
I6K17_RS03560	COG0523	cobalamin synthesis protein
I6K17_RS03565	COG0246	Mannitol dehydrogenase
I6K17_RS03580	COG2814	Major facilitator Superfamily
I6K17_RS03585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS03585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS03590	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K17_RS03595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS03595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS03595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K17_RS03600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS03605	COG2313	pseudouridylate synthase activity
I6K17_RS03610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K17_RS03615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K17_RS03625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K17_RS03630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS03630	COG1522	sequence-specific DNA binding
I6K17_RS03640	COG2855	membrane
I6K17_RS03645	COG0583	DNA-binding transcription factor activity
I6K17_RS03650	COG0833	amino acid
I6K17_RS03660	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6K17_RS03670	COG2311	Membrane
I6K17_RS03675	COG1609	Transcriptional regulator
I6K17_RS03680	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS03685	COG1129	ABC transporter
I6K17_RS03690	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS03695	COG0167	dihydroorotate dehydrogenase activity
I6K17_RS03695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K17_RS03700	COG0493	'glutamate synthase
I6K17_RS03710	COG2949	membrane
I6K17_RS03720	COG1346	cytolysis
I6K17_RS03730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K17_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS03750	COG0586	Pfam SNARE associated Golgi protein
I6K17_RS03760	COG1686	Belongs to the peptidase S11 family
I6K17_RS03765	COG0277	FAD linked oxidase domain protein
I6K17_RS03770	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K17_RS03775	COG1732	Glycine betaine
I6K17_RS03780	COG1174	glycine betaine transport
I6K17_RS03785	COG1125	glycine betaine transport
I6K17_RS03790	COG1174	glycine betaine transport
I6K17_RS03800	COG0789	Transcriptional regulator
I6K17_RS03805	COG3275	phosphorelay sensor kinase activity
I6K17_RS03810	COG3279	Response regulator of the LytR AlgR family
I6K17_RS03815	COG4807	Protein conserved in bacteria
I6K17_RS03820	COG4808	Protein conserved in bacteria
I6K17_RS03825	COG4715	Zinc finger, swim domain protein
I6K17_RS03830	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K17_RS03835	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K17_RS03840	COG0714	Associated with various cellular activities
I6K17_RS03855	COG3831	ATPase activity
I6K17_RS03865	COG0489	protein tyrosine kinase activity
I6K17_RS03875	COG3539	Fimbrial protein
I6K17_RS03880	COG3121	Chaperone
I6K17_RS03885	COG3188	usher protein
I6K17_RS03895	COG5455	response to cobalt ion
I6K17_RS03915	COG0351	phosphomethylpyrimidine kinase
I6K17_RS03925	COG2188	Transcriptional regulator
I6K17_RS03930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS03935	COG1397	ADP-ribosylglycohydrolase
I6K17_RS03940	COG2211	Major facilitator Superfamily
I6K17_RS03960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS03965	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K17_RS03970	COG3775	system Galactitol-specific IIC component
I6K17_RS03975	COG1063	alcohol dehydrogenase
I6K17_RS03995	COG0826	peptidase U32
I6K17_RS04005	COG3609	addiction module antidote protein, CC2985 family
I6K17_RS04015	COG0745	RESPONSE REGULATOR receiver
I6K17_RS04020	COG2205	protein histidine kinase activity
I6K17_RS04070	COG4245	von Willebrand factor, type A
I6K17_RS04075	COG0631	protein serine/threonine phosphatase activity
I6K17_RS04080	COG3779	Protein conserved in bacteria
I6K17_RS04085	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6K17_RS04090	COG0443	Heat shock 70 kDa protein
I6K17_RS04095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K17_RS04100	COG5001	Diguanylate cyclase
I6K17_RS04100	COG3447	MASE1 domain protein
I6K17_RS04100	COG5002	protein histidine kinase activity
I6K17_RS04105	COG0572	uridine kinase
I6K17_RS04115	COG2982	Protein involved in outer membrane biogenesis
I6K17_RS04120	COG1253	flavin adenine dinucleotide binding
I6K17_RS04130	COG1596	polysaccharide export
I6K17_RS04135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K17_RS04140	COG3206	protein involved in exopolysaccharide biosynthesis
I6K17_RS04140	COG0489	protein tyrosine kinase activity
I6K17_RS04145	COG0463	Glycosyl transferase, family 2
I6K17_RS04150	COG1045	serine acetyltransferase
I6K17_RS04155	COG0438	transferase activity, transferring glycosyl groups
I6K17_RS04165	COG1216	Glycosyl transferase, family 2
I6K17_RS04170	COG0110	maltose O-acetyltransferase activity
I6K17_RS04175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6K17_RS04180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K17_RS04185	COG1051	belongs to the nudix hydrolase family
I6K17_RS04190	COG0297	glycogen (starch) synthase activity
I6K17_RS04195	COG0662	Cupin 2, conserved barrel domain protein
I6K17_RS04195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6K17_RS04200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K17_RS04205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K17_RS04210	COG2244	polysaccharide biosynthetic process
I6K17_RS04215	COG2327	Polysaccharide pyruvyl transferase
I6K17_RS04220	COG0438	transferase activity, transferring glycosyl groups
I6K17_RS04230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K17_RS04235	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K17_RS04240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K17_RS04285	COG1216	Glycosyl transferase, family 2
I6K17_RS04290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K17_RS04295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6K17_RS04320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K17_RS04325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K17_RS04325	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K17_RS04350	COG2161	toxin-antitoxin pair type II binding
I6K17_RS04360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K17_RS04365	COG0583	DNA-binding transcription factor activity
I6K17_RS04375	COG0531	amino acid
I6K17_RS04380	COG2391	methyltransferase activity
I6K17_RS04385	COG0425	Belongs to the sulfur carrier protein TusA family
I6K17_RS04390	COG2925	Exonuclease
I6K17_RS04395	COG1686	Belongs to the peptidase S11 family
I6K17_RS04405	COG1289	transmembrane transporter activity
I6K17_RS04450	COG2003	Belongs to the UPF0758 family
I6K17_RS04510	COG4372	Transposase
I6K17_RS04515	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS04575	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K17_RS04605	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6K17_RS04620	COG1376	ErfK ybiS ycfS ynhG family protein
I6K17_RS04630	COG0583	DNA-binding transcription factor activity
I6K17_RS04635	COG0583	DNA-binding transcription factor activity
I6K17_RS04645	COG0534	Mate efflux family protein
I6K17_RS04655	COG0217	transcriptional regulatory protein
I6K17_RS04660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K17_RS04665	COG0477	Major facilitator Superfamily
I6K17_RS04680	COG4932	domain protein
I6K17_RS04680	COG1388	LysM domain
I6K17_RS04680	COG2373	Large extracellular alpha-helical protein
I6K17_RS04685	COG4771	TonB-dependent receptor
I6K17_RS04690	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K17_RS04725	COG1132	(ABC) transporter
I6K17_RS04730	COG2814	Major facilitator Superfamily
I6K17_RS04735	COG1169	isochorismate synthase
I6K17_RS04740	COG0582	viral genome integration into host DNA
I6K17_RS04770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K17_RS04820	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K17_RS04835	COG1403	HNH endonuclease
I6K17_RS04840	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K17_RS04845	COG0484	heat shock protein binding
I6K17_RS04990	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K17_RS04995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS05000	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K17_RS05015	COG2351	hydroxyisourate hydrolase activity
I6K17_RS05020	COG0745	RESPONSE REGULATOR receiver
I6K17_RS05025	COG2205	protein histidine kinase activity
I6K17_RS05035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K17_RS05045	COG1418	mRNA catabolic process
I6K17_RS05050	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K17_RS05055	COG3727	T/G mismatch-specific endonuclease activity
I6K17_RS05060	COG0697	spore germination
I6K17_RS05065	COG2354	Protein conserved in bacteria
I6K17_RS05070	COG5475	Uncharacterized small protein (DUF2158)
I6K17_RS05100	COG2197	response regulator
I6K17_RS05105	COG1684	flagellar biosynthetic protein fliR
I6K17_RS05110	COG1987	bacterial-type flagellum assembly
I6K17_RS05115	COG1338	Plays a role in the flagellum-specific transport system
I6K17_RS05120	COG3190	flagellar
I6K17_RS05125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K17_RS05130	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K17_RS05135	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K17_RS05140	COG3144	bacterial-type flagellum assembly
I6K17_RS05145	COG2882	bacterial-type flagellum organization
I6K17_RS05150	COG1157	protein secretion by the type III secretion system
I6K17_RS05155	COG1317	bacterial-type flagellum organization
I6K17_RS05160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K17_RS05165	COG1766	The M ring may be actively involved in energy transduction
I6K17_RS05175	COG2076	Multidrug Resistance protein
I6K17_RS05180	COG1881	PFAM PEBP family protein
I6K17_RS05185	COG2207	Transcriptional regulator
I6K17_RS05210	COG2135	peptidase activity
I6K17_RS05215	COG0425	Belongs to the sulfur carrier protein TusA family
I6K17_RS05220	COG2391	methyltransferase activity
I6K17_RS05230	COG0366	Alpha amylase catalytic
I6K17_RS05240	COG1516	flagellar protein fliS
I6K17_RS05245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K17_RS05250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K17_RS05255	COG1191	sigma factor activity
I6K17_RS05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS05275	COG0765	amino acid transport
I6K17_RS05280	COG1126	abc transporter atp-binding protein
I6K17_RS05285	COG2197	response regulator
I6K17_RS05300	COG2197	response regulator
I6K17_RS05330	COG3012	SEC-C Motif Domain Protein
I6K17_RS05330	COG3318	Belongs to the UPF0149 family
I6K17_RS05335	COG0814	amino acid
I6K17_RS05345	COG1528	Iron-storage protein
I6K17_RS05365	COG1528	Iron-storage protein
I6K17_RS05370	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS05375	COG1129	ABC transporter
I6K17_RS05380	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS05385	COG1877	trehalose-phosphatase activity
I6K17_RS05395	COG0589	response to stress
I6K17_RS05410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K17_RS05415	COG1360	Flagellar Motor Protein
I6K17_RS05420	COG2198	Histidine kinase
I6K17_RS05420	COG0643	Histidine kinase
I6K17_RS05425	COG0835	chemotaxis
I6K17_RS05435	COG0840	transmembrane signaling receptor activity
I6K17_RS05440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6K17_RS05450	COG0745	RESPONSE REGULATOR receiver
I6K17_RS05455	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K17_RS05460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K17_RS05465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K17_RS05480	COG3102	Protein conserved in bacteria
I6K17_RS05490	COG3005	denitrification pathway
I6K17_RS05495	COG0243	molybdopterin cofactor binding
I6K17_RS05510	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K17_RS05515	COG1801	Protein of unknown function DUF72
I6K17_RS05520	COG1335	isochorismatase
I6K17_RS05530	COG0494	nUDIX hydrolase
I6K17_RS05535	COG0217	transcriptional regulatory protein
I6K17_RS05565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K17_RS05575	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K17_RS05580	COG0739	heme binding
I6K17_RS05585	COG1560	Kdo2-lipid A biosynthetic process
I6K17_RS05590	COG0469	pyruvate kinase activity
I6K17_RS05595	COG1737	Transcriptional regulator
I6K17_RS05600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K17_RS05605	COG0129	dihydroxy-acid dehydratase activity
I6K17_RS05610	COG0800	Aldolase
I6K17_RS05620	COG3141	response to X-ray
I6K17_RS05630	COG2979	Protein of unknown function (DUF533)
I6K17_RS05635	COG1770	oligopeptidase
I6K17_RS05640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K17_RS05645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K17_RS05655	COG2372	response to copper ion
I6K17_RS05670	COG0582	viral genome integration into host DNA
I6K17_RS05690	COG3723	Recombinational DNA repair protein, rece pathway
I6K17_RS05695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K17_RS05725	COG4197	protein conserved in bacteria, prophage-related
I6K17_RS05735	COG3756	Protein conserved in bacteria
I6K17_RS05740	COG1484	DNA-dependent DNA replication
I6K17_RS05745	COG1846	Transcriptional regulator
I6K17_RS05825	COG3728	DNA packaging
I6K17_RS05825	COG5484	DNA packaging
I6K17_RS05830	COG1783	phage Terminase large subunit
I6K17_RS05980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K17_RS05985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K17_RS06005	COG3008	intermembrane lipid transfer
I6K17_RS06010	COG2995	paraquat-inducible protein a
I6K17_RS06015	COG1956	GAF domain-containing protein
I6K17_RS06025	COG0793	Belongs to the peptidase S41A family
I6K17_RS06040	COG2814	Major facilitator Superfamily
I6K17_RS06045	COG1414	Transcriptional regulator
I6K17_RS06075	COG2226	methyltransferase
I6K17_RS06090	COG3716	PTS system mannose fructose sorbose family IID component
I6K17_RS06095	COG3715	PTS system
I6K17_RS06100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS06100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS06105	COG1253	flavin adenine dinucleotide binding
I6K17_RS06110	COG2200	EAL domain
I6K17_RS06115	COG1760	l-serine dehydratase
I6K17_RS06125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K17_RS06140	COG0251	oxidation-reduction process
I6K17_RS06145	COG1199	ATP-dependent helicase activity
I6K17_RS06150	COG1214	PFAM Peptidase M22, glycoprotease
I6K17_RS06155	COG3065	identical protein binding
I6K17_RS06160	COG0318	PFAM AMP-dependent synthetase and ligase
I6K17_RS06165	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K17_RS06170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K17_RS06175	COG4638	Rieske (2fe-2S)
I6K17_RS06180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K17_RS06185	COG0473	3-isopropylmalate dehydrogenase activity
I6K17_RS06190	COG0583	DNA-binding transcription factor activity
I6K17_RS06200	COG3615	Tellurite resistance protein tehB
I6K17_RS06210	COG2261	transglycosylase associated protein
I6K17_RS06225	COG2203	Gaf domain
I6K17_RS06225	COG2199	diguanylate cyclase activity
I6K17_RS06230	COG3042	response to heat
I6K17_RS06235	COG3189	MarR family transcriptional regulator
I6K17_RS06240	COG2807	transmembrane transport
I6K17_RS06245	COG2207	Transcriptional regulator
I6K17_RS06260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K17_RS06265	COG2199	diguanylate cyclase activity
I6K17_RS06270	COG2199	diguanylate cyclase activity
I6K17_RS06280	COG2766	serine protein kinase
I6K17_RS06285	COG3713	MltA-interacting MipA family protein
I6K17_RS06290	COG0656	L-ascorbic acid biosynthetic process
I6K17_RS06295	COG0676	glucose-6-phosphate 1-epimerase activity
I6K17_RS06300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K17_RS06310	COG3139	Protein of unknown function (DUF1315)
I6K17_RS06315	COG1335	isochorismatase
I6K17_RS06320	COG0252	asparaginase activity
I6K17_RS06325	COG0616	signal peptide processing
I6K17_RS06330	COG0778	Nitroreductase
I6K17_RS06335	COG0709	Synthesizes selenophosphate from selenide and ATP
I6K17_RS06340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K17_RS06345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K17_RS06355	COG0494	nUDIX hydrolase
I6K17_RS06360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K17_RS06365	COG2897	thiosulfate sulfurtransferase activity
I6K17_RS06370	COG4136	ATPase activity
I6K17_RS06375	COG4135	transport system, permease component
I6K17_RS06380	COG4134	Bacterial extracellular solute-binding protein
I6K17_RS06385	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K17_RS06390	COG0398	Pfam SNARE associated Golgi protein
I6K17_RS06400	COG0398	Pfam SNARE associated Golgi protein
I6K17_RS06405	COG0708	Exodeoxyribonuclease III
I6K17_RS06435	COG3678	ATP-independent chaperone mediated protein folding
I6K17_RS06445	COG0322	excinuclease ABC activity
I6K17_RS06455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K17_RS06460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K17_RS06480	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K17_RS06485	COG1917	Cupin 2, conserved barrel domain protein
I6K17_RS06485	COG2169	Transcriptional regulator
I6K17_RS06490	COG1486	melibiose metabolic process
I6K17_RS06495	COG3394	polysaccharide catabolic process
I6K17_RS06500	COG0753	catalase activity
I6K17_RS06510	COG1823	symporter activity
I6K17_RS06515	COG1988	membrane-bound metal-dependent
I6K17_RS06520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K17_RS06530	COG3001	Fructosamine kinase
I6K17_RS06540	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K17_RS06545	COG3137	Salt-induced outer membrane protein
I6K17_RS06605	COG0386	Belongs to the glutathione peroxidase family
I6K17_RS06615	COG0791	NLP P60 protein
I6K17_RS06620	COG2200	EAL domain
I6K17_RS06630	COG4256	Hemin uptake protein
I6K17_RS06635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K17_RS06645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K17_RS06645	COG0574	Belongs to the PEP-utilizing enzyme family
I6K17_RS06650	COG0318	PFAM AMP-dependent synthetase and ligase
I6K17_RS06655	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K17_RS06660	COG0644	oxidoreductase
I6K17_RS06665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K17_RS06670	COG2086	electron transfer activity
I6K17_RS06675	COG1917	Cupin 2, conserved barrel domain protein
I6K17_RS06675	COG2207	Transcriptional regulator
I6K17_RS06685	COG4670	ketone body catabolic process
I6K17_RS06700	COG2271	Major facilitator Superfamily
I6K17_RS06705	COG0738	Major facilitator superfamily
I6K17_RS06720	COG0628	permease
I6K17_RS06725	COG0277	FAD linked oxidase domain protein
I6K17_RS06725	COG0247	lactate metabolic process
I6K17_RS06730	COG2050	protein possibly involved in aromatic compounds catabolism
I6K17_RS06740	COG0316	Belongs to the HesB IscA family
I6K17_RS06745	COG0719	Fe-S assembly protein
I6K17_RS06750	COG0396	ATPase activity
I6K17_RS06755	COG0719	Fe-S assembly protein
I6K17_RS06770	COG1376	ErfK ybiS ycfS ynhG family protein
I6K17_RS06775	COG4238	major outer membrane lipoprotein
I6K17_RS06780	COG0469	pyruvate kinase activity
I6K17_RS06790	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS06795	COG2414	aldehyde ferredoxin oxidoreductase
I6K17_RS06805	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS06810	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6K17_RS06820	COG4529	Protein conserved in bacteria
I6K17_RS06840	COG3468	outer membrane autotransporter barrel domain protein
I6K17_RS06850	COG0307	riboflavin synthase, alpha
I6K17_RS06855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K17_RS06860	COG2814	Major facilitator Superfamily
I6K17_RS06865	COG0583	DNA-binding transcription factor activity
I6K17_RS06880	COG2814	Major facilitator Superfamily
I6K17_RS06885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K17_RS06890	COG0791	NLP P60 protein
I6K17_RS06895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K17_RS06900	COG1201	RNA secondary structure unwinding
I6K17_RS06910	COG0346	lactoylglutathione lyase activity
I6K17_RS06915	COG1902	pentaerythritol trinitrate reductase activity
I6K17_RS06920	COG1309	transcriptional regulator
I6K17_RS06925	COG3313	Fe-S protein
I6K17_RS06930	COG4989	oxidoreductase activity
I6K17_RS06935	COG2032	superoxide dismutase activity
I6K17_RS06945	COG1566	PFAM secretion protein HlyD family protein
I6K17_RS06960	COG3133	Outer membrane lipoprotein
I6K17_RS06970	COG3895	Periplasmic Protein
I6K17_RS06985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K17_RS06990	COG0625	glutathione transferase activity
I6K17_RS06995	COG3104	oligopeptide transport
I6K17_RS07000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K17_RS07010	COG4659	FMN binding
I6K17_RS07050	COG0673	inositol 2-dehydrogenase activity
I6K17_RS07060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K17_RS07065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS07065	COG1263	PTS System
I6K17_RS07070	COG1609	Transcriptional regulator
I6K17_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS07080	COG1309	transcriptional regulator
I6K17_RS07085	COG3250	beta-galactosidase activity
I6K17_RS07100	COG5339	Protein conserved in bacteria
I6K17_RS07105	COG1482	cell wall glycoprotein biosynthetic process
I6K17_RS07110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K17_RS07110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K17_RS07115	COG0114	fumarate hydratase activity
I6K17_RS07125	COG2205	protein histidine kinase activity
I6K17_RS07130	COG0745	RESPONSE REGULATOR receiver
I6K17_RS07135	COG3136	membrane protein required for alginate biosynthesis
I6K17_RS07145	COG0531	amino acid
I6K17_RS07155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K17_RS07160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K17_RS07165	COG0628	permease
I6K17_RS07180	COG3591	Belongs to the peptidase S1B family
I6K17_RS07195	COG2814	Major facilitator Superfamily
I6K17_RS07200	COG0583	DNA-binding transcription factor activity
I6K17_RS07205	COG1940	carbohydrate kinase activity
I6K17_RS07210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K17_RS07220	COG3381	protein complex oligomerization
I6K17_RS07225	COG3302	dmso reductase anchor subunit
I6K17_RS07230	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS07235	COG0243	molybdopterin cofactor binding
I6K17_RS07240	COG0243	molybdopterin cofactor binding
I6K17_RS07255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K17_RS07270	COG4948	Mandelate Racemase Muconate Lactonizing
I6K17_RS07275	COG1063	alcohol dehydrogenase
I6K17_RS07285	COG0582	viral genome integration into host DNA
I6K17_RS07295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K17_RS07325	COG1396	sequence-specific DNA binding
I6K17_RS07340	COG1846	Transcriptional regulator
I6K17_RS07370	COG1403	HNH endonuclease
I6K17_RS07375	COG0484	heat shock protein binding
I6K17_RS07385	COG1278	Cold shock
I6K17_RS07400	COG3772	lysozyme
I6K17_RS07410	COG1278	Cold shock
I6K17_RS07435	COG5562	phage envelope protein
I6K17_RS07465	COG0740	serine-type endopeptidase activity
I6K17_RS07540	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K17_RS07545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS07550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K17_RS07570	COG0246	Mannitol dehydrogenase
I6K17_RS07580	COG1802	Transcriptional regulator
I6K17_RS07585	COG4221	oxidoreductase activity
I6K17_RS07590	COG0339	signal peptide processing
I6K17_RS07595	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K17_RS07600	COG3706	GGDEF domain
I6K17_RS07610	COG2814	Major facilitator Superfamily
I6K17_RS07615	COG0697	spore germination
I6K17_RS07625	COG4977	sequence-specific DNA binding
I6K17_RS07630	COG1846	Transcriptional regulator
I6K17_RS07650	COG0583	DNA-binding transcription factor activity
I6K17_RS07655	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS07660	COG2066	Belongs to the glutaminase family
I6K17_RS07670	COG2199	diguanylate cyclase activity
I6K17_RS07680	COG3781	membrane
I6K17_RS07735	COG1396	sequence-specific DNA binding
I6K17_RS07740	COG3550	peptidyl-serine autophosphorylation
I6K17_RS07750	COG3539	Fimbrial protein
I6K17_RS07765	COG3539	Fimbrial protein
I6K17_RS07770	COG3539	Fimbrial protein
I6K17_RS07775	COG3539	Fimbrial protein
I6K17_RS07780	COG0243	molybdopterin cofactor binding
I6K17_RS07790	COG2207	Transcriptional regulator
I6K17_RS07795	COG3119	arylsulfatase activity
I6K17_RS07800	COG0641	radical SAM
I6K17_RS07810	COG4178	(ABC) transporter
I6K17_RS07815	COG4771	TonB-dependent receptor
I6K17_RS07820	COG0612	Peptidase, M16
I6K17_RS07825	COG0076	glutamate decarboxylase activity
I6K17_RS07830	COG0531	amino acid
I6K17_RS07835	COG1649	PFAM Uncharacterised BCR, COG1649
I6K17_RS07850	COG2202	Pas domain
I6K17_RS07850	COG2199	diguanylate cyclase activity
I6K17_RS07850	COG2200	EAL domain
I6K17_RS07855	COG1764	response to oxidative stress
I6K17_RS07875	COG1064	alcohol dehydrogenase
I6K17_RS07880	COG3093	addiction module antidote protein HigA
I6K17_RS07890	COG2864	formate dehydrogenase
I6K17_RS07895	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS07910	COG2223	nitrite transmembrane transporter activity
I6K17_RS07915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K17_RS07920	COG1140	nitrate reductase beta subunit
I6K17_RS07925	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K17_RS07930	COG2181	nitrate reductase activity
I6K17_RS07935	COG0384	phenazine biosynthesis protein PhzF
I6K17_RS07940	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K17_RS07945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K17_RS07955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K17_RS07960	COG2203	Gaf domain
I6K17_RS07960	COG5001	Diguanylate cyclase
I6K17_RS07960	COG4251	negative regulation of phosphorylation
I6K17_RS07960	COG3706	GGDEF domain
I6K17_RS08010	COG1113	amino acid transport
I6K17_RS08015	COG3391	amine dehydrogenase activity
I6K17_RS08020	COG4772	TonB-dependent receptor
I6K17_RS08025	COG1802	Transcriptional regulator
I6K17_RS08030	COG2130	NADP-dependent
I6K17_RS08035	COG1247	-acetyltransferase
I6K17_RS08040	COG3238	Protein conserved in bacteria
I6K17_RS08065	COG1177	transmembrane transport
I6K17_RS08070	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K17_RS08075	COG3842	ATPase activity
I6K17_RS08080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K17_RS08085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K17_RS08090	COG1598	PFAM Uncharacterised protein family UPF0150
I6K17_RS08095	COG1724	mRNA binding
I6K17_RS08105	COG0826	peptidase U32
I6K17_RS08110	COG1396	sequence-specific DNA binding
I6K17_RS08115	COG3135	benzoate transporter
I6K17_RS08125	COG0500	methyltransferase
I6K17_RS08130	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K17_RS08135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K17_RS08140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K17_RS08145	COG2841	Protein conserved in bacteria
I6K17_RS08155	COG5383	Protein conserved in bacteria
I6K17_RS08160	COG0583	DNA-binding transcription factor activity
I6K17_RS08165	COG0840	transmembrane signaling receptor activity
I6K17_RS08180	COG3038	cytochrome b561
I6K17_RS08185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K17_RS08190	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS08195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K17_RS08200	COG1643	Atp-dependent helicase
I6K17_RS08210	COG0671	phosphoesterase, PA-phosphatase related
I6K17_RS08210	COG2453	phosphatase
I6K17_RS08215	COG2267	carboxylic ester hydrolase activity
I6K17_RS08220	COG4589	Belongs to the CDS family
I6K17_RS08225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K17_RS08240	COG0667	Aldo Keto reductase
I6K17_RS08245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K17_RS08250	COG3327	negative regulation of DNA-templated transcription, initiation
I6K17_RS08255	COG2207	Transcriptional regulator
I6K17_RS08260	COG3784	Protein of unknown function (DUF1318)
I6K17_RS08270	COG2911	Protein conserved in bacteria
I6K17_RS08275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K17_RS08280	COG3187	Heat shock protein
I6K17_RS08285	COG3042	response to heat
I6K17_RS08290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K17_RS08290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K17_RS08290	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K17_RS08290	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K17_RS08295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K17_RS08300	COG0589	response to stress
I6K17_RS08310	COG0513	Belongs to the DEAD box helicase family
I6K17_RS08325	COG3706	GGDEF domain
I6K17_RS08330	COG2840	Smr protein MutS2
I6K17_RS08345	COG2207	Transcriptional regulator
I6K17_RS08355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K17_RS08360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K17_RS08365	COG0589	response to stress
I6K17_RS08370	COG3182	Iron-regulated membrane protein
I6K17_RS08375	COG0668	transmembrane transport
I6K17_RS08380	COG4166	transmembrane transport
I6K17_RS08385	COG0583	DNA-binding transcription factor activity
I6K17_RS08390	COG1073	alpha beta
I6K17_RS08395	COG0702	epimerase
I6K17_RS08400	COG2866	Carboxypeptidase
I6K17_RS08405	COG4948	Mandelate Racemase Muconate Lactonizing
I6K17_RS08410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K17_RS08415	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6K17_RS08425	COG3106	COG3106 Predicted ATPase
I6K17_RS08430	COG1609	Transcriptional regulator
I6K17_RS08445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K17_RS08450	COG1554	hydrolase, family 65, central catalytic
I6K17_RS08455	COG0673	inositol 2-dehydrogenase activity
I6K17_RS08460	COG1082	Xylose isomerase domain protein TIM barrel
I6K17_RS08465	COG1063	alcohol dehydrogenase
I6K17_RS08470	COG0395	ABC-type sugar transport system, permease component
I6K17_RS08475	COG1175	transmembrane transport
I6K17_RS08480	COG1653	transport
I6K17_RS08485	COG0366	Alpha amylase catalytic
I6K17_RS08490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K17_RS08500	COG1983	PspC domain protein
I6K17_RS08510	COG1842	Phage shock protein A
I6K17_RS08515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K17_RS08520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K17_RS08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K17_RS08530	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS08535	COG1917	Cupin 2, conserved barrel domain protein
I6K17_RS08535	COG1396	sequence-specific DNA binding
I6K17_RS08545	COG0174	glutamine synthetase
I6K17_RS08555	COG0531	amino acid
I6K17_RS08565	COG4166	transmembrane transport
I6K17_RS08570	COG4168	peptide transport system, permease
I6K17_RS08575	COG4171	peptide transport system, permease
I6K17_RS08580	COG4172	Belongs to the ABC transporter superfamily
I6K17_RS08585	COG4172	Belongs to the ABC transporter superfamily
I6K17_RS08590	COG2814	Major facilitator Superfamily
I6K17_RS08600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K17_RS08605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS08615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K17_RS08620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K17_RS08620	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K17_RS08635	COG5001	Diguanylate cyclase
I6K17_RS08645	COG1349	DNA-binding transcription factor activity
I6K17_RS08655	COG0023	Translation Initiation Factor
I6K17_RS08665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K17_RS08670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K17_RS08675	COG0671	phosphoesterase, PA-phosphatase related
I6K17_RS08685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K17_RS08705	COG0583	DNA-binding transcription factor activity
I6K17_RS08710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K17_RS08720	COG0616	signal peptide processing
I6K17_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS08730	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K17_RS08745	COG1187	pseudouridine synthase activity
I6K17_RS08750	COG4907	membrane protein (DUF2207)
I6K17_RS08755	COG0009	L-threonylcarbamoyladenylate synthase
I6K17_RS08760	COG0613	PHP domain protein
I6K17_RS08770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K17_RS08775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K17_RS08775	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K17_RS08780	COG0134	indole-3-glycerol-phosphate synthase activity
I6K17_RS08780	COG0135	phosphoribosylanthranilate isomerase activity
I6K17_RS08795	COG3729	General stress protein
I6K17_RS08800	COG3685	Protein conserved in bacteria
I6K17_RS08805	COG3685	Protein conserved in bacteria
I6K17_RS08810	COG3047	cAMP biosynthetic process
I6K17_RS08830	COG1607	acyl-coa hydrolase
I6K17_RS08835	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K17_RS08840	COG2350	Protein conserved in bacteria
I6K17_RS08845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K17_RS08865	COG4608	Belongs to the ABC transporter superfamily
I6K17_RS08870	COG0444	Belongs to the ABC transporter superfamily
I6K17_RS08875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K17_RS08880	COG0601	transmembrane transport
I6K17_RS08885	COG4166	transmembrane transport
I6K17_RS08895	COG2095	MarC family integral membrane protein
I6K17_RS08900	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS08900	COG1454	alcohol dehydrogenase
I6K17_RS08905	COG1435	thymidine kinase activity
I6K17_RS08915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K17_RS08920	COG0745	RESPONSE REGULATOR receiver
I6K17_RS08925	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K17_RS08935	COG0788	formyltetrahydrofolate deformylase activity
I6K17_RS08955	COG2181	nitrate reductase activity
I6K17_RS08960	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K17_RS08965	COG1140	nitrate reductase beta subunit
I6K17_RS08970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K17_RS08975	COG2223	nitrite transmembrane transporter activity
I6K17_RS08980	COG3850	Histidine kinase
I6K17_RS08985	COG2197	response regulator
I6K17_RS08990	COG4932	domain protein
I6K17_RS08995	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K17_RS09000	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K17_RS09005	COG4572	Cation transport regulator
I6K17_RS09010	COG0387	Pfam Sodium calcium exchanger
I6K17_RS09025	COG2912	Transglutaminase-like superfamily
I6K17_RS09030	COG3094	Invasion gene expression up-regulator, SirB
I6K17_RS09035	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K17_RS09060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K17_RS09065	COG0659	secondary active sulfate transmembrane transporter activity
I6K17_RS09080	COG0012	GTP binding
I6K17_RS09090	COG3284	Transcriptional regulator
I6K17_RS09095	COG2376	Dihydroxyacetone kinase
I6K17_RS09100	COG1461	Dihydroxyacetone kinase
I6K17_RS09105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K17_RS09105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS09105	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K17_RS09115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K17_RS09120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS09125	COG1120	ATPase activity
I6K17_RS09130	COG0500	methyltransferase
I6K17_RS09135	COG0157	Belongs to the NadC ModD family
I6K17_RS09150	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K17_RS09160	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K17_RS09170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K17_RS09180	COG2719	SpoVR family
I6K17_RS09190	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6K17_RS09200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K17_RS09205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K17_RS09220	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K17_RS09245	COG2894	cell division
I6K17_RS09295	COG2200	EAL domain
I6K17_RS09320	COG2200	EAL domain
I6K17_RS09325	COG0789	Transcriptional regulator
I6K17_RS09330	COG5562	phage envelope protein
I6K17_RS09345	COG0538	isocitrate dehydrogenase activity
I6K17_RS09350	COG1187	pseudouridine synthase activity
I6K17_RS09370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K17_RS09380	COG2205	protein histidine kinase activity
I6K17_RS09385	COG2850	peptidyl-arginine hydroxylation
I6K17_RS09395	COG3842	ATPase activity
I6K17_RS09405	COG1177	transmembrane transport
I6K17_RS09410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K17_RS09420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K17_RS09425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K17_RS09435	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K17_RS09445	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K17_RS09450	COG4763	Acyl-transferase
I6K17_RS09455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K17_RS09460	COG1376	ErfK ybiS ycfS ynhG family protein
I6K17_RS09460	COG1388	LysM domain
I6K17_RS09470	COG1309	transcriptional regulator
I6K17_RS09475	COG3134	Outer membrane lipoprotein
I6K17_RS09480	COG1252	NADH dehydrogenase
I6K17_RS09500	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6K17_RS09505	COG5633	Lipoprotein
I6K17_RS09510	COG0537	adenosine 5'-monophosphoramidase activity
I6K17_RS09515	COG4773	Receptor
I6K17_RS09520	COG1263	PTS System
I6K17_RS09520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS09525	COG0084	hydrolase, TatD family'
I6K17_RS09530	COG0470	DNA polymerase III
I6K17_RS09540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K17_RS09545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K17_RS09555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K17_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS09570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K17_RS09590	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K17_RS09595	COG0424	maF-like protein
I6K17_RS09600	COG0564	pseudouridine synthase activity
I6K17_RS09605	COG1530	ribonuclease E activity
I6K17_RS09620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K17_RS09625	COG1256	bacterial-type flagellum assembly
I6K17_RS09630	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6K17_RS09630	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K17_RS09645	COG4786	Flagellar basal body rod
I6K17_RS09650	COG4787	bacterial-type flagellum-dependent cell motility
I6K17_RS09655	COG1749	Flagellar hook protein flgE
I6K17_RS09660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6K17_RS09665	COG1558	bacterial-type flagellum-dependent cell motility
I6K17_RS09670	COG1815	bacterial-type flagellum-dependent cell motility
I6K17_RS09675	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6K17_RS09680	COG2747	anti-sigma28 factor FlgM
I6K17_RS09685	COG3418	PFAM FlgN family protein
I6K17_RS09690	COG0728	peptidoglycan biosynthetic process
I6K17_RS09695	COG0673	inositol 2-dehydrogenase activity
I6K17_RS09705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K17_RS09715	COG2999	glutathione oxidoreductase activity
I6K17_RS09750	COG3038	cytochrome b561
I6K17_RS09755	COG2353	YceI-like domain
I6K17_RS09765	COG1560	Kdo2-lipid A biosynthetic process
I6K17_RS09780	COG5645	(Lipo)protein
I6K17_RS09785	COG2943	transferase activity, transferring hexosyl groups
I6K17_RS09800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K17_RS09805	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS09830	COG2197	response regulator
I6K17_RS09845	COG1462	curli production assembly transport component CsgG
I6K17_RS09855	COG3381	protein complex oligomerization
I6K17_RS09895	COG1702	phosphate starvation-inducible protein PhoH
I6K17_RS09905	COG2822	iron ion transport
I6K17_RS09915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K17_RS09925	COG0506	proline dehydrogenase activity
I6K17_RS09925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K17_RS09925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K17_RS09930	COG1309	transcriptional regulator
I6K17_RS09965	COG2233	PERMEase
I6K17_RS09970	COG3729	General stress protein
I6K17_RS10005	COG0243	molybdopterin cofactor binding
I6K17_RS10010	COG3005	denitrification pathway
I6K17_RS10015	COG0745	RESPONSE REGULATOR receiver
I6K17_RS10020	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS10025	COG0784	Response regulator, receiver
I6K17_RS10025	COG2198	Histidine kinase
I6K17_RS10025	COG2205	protein histidine kinase activity
I6K17_RS10030	COG0348	domain, Protein
I6K17_RS10050	COG1278	Cold shock
I6K17_RS10055	COG1278	Cold shock
I6K17_RS10075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K17_RS10080	COG1596	polysaccharide export
I6K17_RS10085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K17_RS10090	COG3206	protein involved in exopolysaccharide biosynthesis
I6K17_RS10090	COG0489	protein tyrosine kinase activity
I6K17_RS10105	COG1294	oxidase, subunit
I6K17_RS10110	COG1271	oxidase subunit
I6K17_RS10115	COG1773	rubredoxin
I6K17_RS10120	COG1999	signal sequence binding
I6K17_RS10125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K17_RS10130	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6K17_RS10135	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K17_RS10140	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K17_RS10150	COG0670	Belongs to the BI1 family
I6K17_RS10155	COG2920	part of a sulfur-relay system
I6K17_RS10160	COG1254	Belongs to the acylphosphatase family
I6K17_RS10175	COG1832	CoA-binding protein
I6K17_RS10190	COG0210	DNA helicase
I6K17_RS10195	COG3304	Inner membrane component domain
I6K17_RS10200	COG1289	transmembrane transporter activity
I6K17_RS10205	COG3070	regulator of competence-specific genes
I6K17_RS10215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K17_RS10215	COG2885	chlorophyll binding
I6K17_RS10225	COG1067	ATP-dependent peptidase activity
I6K17_RS10235	COG3130	regulation of translation
I6K17_RS10240	COG3009	Protein conserved in bacteria
I6K17_RS10245	COG3008	intermembrane lipid transfer
I6K17_RS10245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K17_RS10250	COG2995	paraquat-inducible protein a
I6K17_RS10255	COG0488	(ABC) transporter
I6K17_RS10265	COG0633	Ferredoxin
I6K17_RS10265	COG3217	Mosc domain protein beta barrel domain protein
I6K17_RS10280	COG0431	NADPH-dependent FMN reductase
I6K17_RS10285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K17_RS10295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K17_RS10305	COG0308	aminopeptidase N
I6K17_RS10325	COG1448	Aminotransferase
I6K17_RS10330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K17_RS10335	COG3108	Peptidase M15
I6K17_RS10340	COG2989	Protein conserved in bacteria
I6K17_RS10355	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K17_RS10365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K17_RS10370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K17_RS10375	COG3173	Aminoglycoside phosphotransferase
I6K17_RS10390	COG3214	Protein conserved in bacteria
I6K17_RS10405	COG2333	competence protein COMEC
I6K17_RS10405	COG0658	competence protein
I6K17_RS10415	COG0539	negative regulation of cytoplasmic translation
I6K17_RS10425	COG0501	Belongs to the peptidase M48B family
I6K17_RS10440	COG2323	membrane
I6K17_RS10445	COG1944	ATP diphosphatase activity
I6K17_RS10450	COG2116	formate transmembrane transporter activity
I6K17_RS10455	COG1882	Formate acetyltransferase
I6K17_RS10460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K17_RS10470	COG0531	amino acid
I6K17_RS10480	COG1335	isochorismatase
I6K17_RS10485	COG3302	dmso reductase anchor subunit
I6K17_RS10490	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS10495	COG0243	molybdopterin cofactor binding
I6K17_RS10505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K17_RS10520	COG1522	sequence-specific DNA binding
I6K17_RS10525	COG0492	ferredoxin-NADP+ reductase activity
I6K17_RS10530	COG4988	ABC transporter
I6K17_RS10535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K17_RS10555	COG0542	response to heat
I6K17_RS10565	COG1278	Cold shock
I6K17_RS10575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS10580	COG2990	Protein conserved in bacteria
I6K17_RS10585	COG3593	DNA synthesis involved in DNA repair
I6K17_RS10590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K17_RS10595	COG2431	L-lysine efflux transmembrane transporter activity
I6K17_RS10605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K17_RS10610	COG0028	Belongs to the TPP enzyme family
I6K17_RS10615	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K17_RS10620	COG0702	epimerase
I6K17_RS10625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K17_RS10630	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K17_RS10645	COG1126	abc transporter atp-binding protein
I6K17_RS10650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS10655	COG4215	(ABC) transporter
I6K17_RS10660	COG4160	amino acid transport
I6K17_RS10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS10680	COG1177	transmembrane transport
I6K17_RS10685	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K17_RS10690	COG3842	ATPase activity
I6K17_RS10695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K17_RS10720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K17_RS10735	COG3226	Transcriptional regulator
I6K17_RS10740	COG0738	Major facilitator superfamily
I6K17_RS10745	COG0561	phosphatase activity
I6K17_RS10755	COG2814	Major facilitator Superfamily
I6K17_RS10760	COG0671	phosphoesterase, PA-phosphatase related
I6K17_RS10765	COG1349	DNA-binding transcription factor activity
I6K17_RS10770	COG1686	Belongs to the peptidase S11 family
I6K17_RS10775	COG0625	glutathione transferase activity
I6K17_RS10780	COG2133	pyrroloquinoline quinone binding
I6K17_RS10805	COG2199	diguanylate cyclase activity
I6K17_RS10835	COG1446	asparaginase
I6K17_RS10840	COG0303	'Molybdopterin
I6K17_RS10845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K17_RS10850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K17_RS10855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K17_RS10860	COG1882	Formate acetyltransferase
I6K17_RS10865	COG0561	phosphatase activity
I6K17_RS10875	COG0488	(ABC) transporter
I6K17_RS10880	COG1376	ErfK ybiS ycfS ynhG family protein
I6K17_RS10885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K17_RS10890	COG1321	iron dependent repressor
I6K17_RS10900	COG2194	sulfuric ester hydrolase activity
I6K17_RS10905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K17_RS10915	COG5006	permease, DMT superfamily
I6K17_RS10925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS10930	COG0765	amino acid transport
I6K17_RS10935	COG1126	abc transporter atp-binding protein
I6K17_RS10940	COG0668	transmembrane transport
I6K17_RS10965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K17_RS10975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K17_RS10980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K17_RS10985	COG1199	ATP-dependent helicase activity
I6K17_RS10995	COG0513	Belongs to the DEAD box helicase family
I6K17_RS11000	COG1309	transcriptional regulator
I6K17_RS11010	COG1131	(ABC) transporter
I6K17_RS11015	COG0842	Transport permease protein
I6K17_RS11020	COG0842	Transport permease protein
I6K17_RS11030	COG3568	Endonuclease Exonuclease Phosphatase
I6K17_RS11035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K17_RS11040	COG0392	lysyltransferase activity
I6K17_RS11045	COG0670	Belongs to the BI1 family
I6K17_RS11050	COG0670	Belongs to the BI1 family
I6K17_RS11055	COG0314	molybdopterin synthase activity
I6K17_RS11060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K17_RS11070	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K17_RS11080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K17_RS11090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K17_RS11095	COG2226	methyltransferase
I6K17_RS11110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K17_RS11115	COG1881	PFAM PEBP family protein
I6K17_RS11130	COG2207	Transcriptional regulator
I6K17_RS11140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS11145	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K17_RS11180	COG1196	nuclear chromosome segregation
I6K17_RS11230	COG1030	water channel activity
I6K17_RS11245	COG4220	transposase activity
I6K17_RS11340	COG4220	transposase activity
I6K17_RS11360	COG3772	lysozyme
I6K17_RS11530	COG0582	viral genome integration into host DNA
I6K17_RS11535	COG4677	pectinesterase activity
I6K17_RS11540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K17_RS11545	COG0471	metal ion transport
I6K17_RS11550	COG2828	Protein conserved in bacteria
I6K17_RS11555	COG0583	DNA-binding transcription factor activity
I6K17_RS11565	COG0561	phosphatase activity
I6K17_RS11575	COG4149	molybdate abc transporter
I6K17_RS11580	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K17_RS11590	COG2005	Transcriptional regulator
I6K17_RS11590	COG3585	molybdate ion transport
I6K17_RS11595	COG1119	ATPase activity
I6K17_RS11600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K17_RS11605	COG1085	galactose-1-phosphate uridylyltransferase
I6K17_RS11615	COG2017	converts alpha-aldose to the beta-anomer
I6K17_RS11625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K17_RS11635	COG1230	cation diffusion facilitator family transporter
I6K17_RS11640	COG3201	nicotinamide mononucleotide transporter
I6K17_RS11685	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K17_RS11690	COG2885	chlorophyll binding
I6K17_RS11700	COG3064	Membrane
I6K17_RS11705	COG0848	biopolymer transport protein
I6K17_RS11710	COG0811	peptide transport
I6K17_RS11715	COG0824	Thioesterase
I6K17_RS11720	COG3790	cyd operon protein YbgE
I6K17_RS11725	COG4890	Cyd operon protein YbgT
I6K17_RS11730	COG1294	oxidase, subunit
I6K17_RS11735	COG1271	oxidase subunit
I6K17_RS11745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K17_RS11755	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K17_RS11760	COG0567	Dehydrogenase, E1 component
I6K17_RS11765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K17_RS11770	COG1053	succinate dehydrogenase
I6K17_RS11775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K17_RS11780	COG2009	succinate dehydrogenase
I6K17_RS11790	COG0372	Belongs to the citrate synthase family
I6K17_RS11795	COG3539	Fimbrial protein
I6K17_RS11800	COG3188	usher protein
I6K17_RS11805	COG3121	Chaperone
I6K17_RS11810	COG3539	Fimbrial protein
I6K17_RS11815	COG3180	Ammonia monooxygenase
I6K17_RS11820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K17_RS11830	COG1984	allophanate hydrolase subunit 2
I6K17_RS11835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K17_RS11840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K17_RS11850	COG0415	Belongs to the DNA photolyase family
I6K17_RS11855	COG3272	Protein of unknown function (DUF1722)
I6K17_RS11880	COG5433	transposase activity
I6K17_RS11895	COG3209	COG3209 Rhs family protein
I6K17_RS11915	COG3209	COG3209 Rhs family protein
I6K17_RS11950	COG2205	protein histidine kinase activity
I6K17_RS11955	COG0745	RESPONSE REGULATOR receiver
I6K17_RS11965	COG1982	Orn Lys Arg decarboxylase major
I6K17_RS11970	COG0531	amino acid
I6K17_RS11990	COG0033	Phosphoglucomutase
I6K17_RS11995	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K17_RS12000	COG0596	Alpha beta hydrolase
I6K17_RS12010	COG0716	FMN binding
I6K17_RS12020	COG0735	belongs to the Fur family
I6K17_RS12045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS12045	COG1263	PTS System
I6K17_RS12045	COG2190	(PTS) system
I6K17_RS12055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K17_RS12060	COG1846	Transcriptional regulator
I6K17_RS12060	COG1940	carbohydrate kinase activity
I6K17_RS12065	COG0647	UMP catabolic process
I6K17_RS12070	COG0367	asparagine synthase
I6K17_RS12115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K17_RS12125	COG1702	phosphate starvation-inducible protein PhoH
I6K17_RS12135	COG4535	Mg2 and Co2 transporter CorC
I6K17_RS12140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6K17_RS12150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS12155	COG0765	amino acid transport
I6K17_RS12160	COG0765	amino acid transport
I6K17_RS12165	COG1126	abc transporter atp-binding protein
I6K17_RS12175	COG2888	peptidyl-tyrosine sulfation
I6K17_RS12190	COG1466	dna polymerase III delta subunit
I6K17_RS12200	COG0406	alpha-ribazole phosphatase activity
I6K17_RS12205	COG0799	negative regulation of ribosome biogenesis
I6K17_RS12215	COG0768	penicillin binding
I6K17_RS12220	COG0772	Belongs to the SEDS family
I6K17_RS12225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K17_RS12230	COG1686	Belongs to the peptidase S11 family
I6K17_RS12245	COG0583	DNA-binding transcription factor activity
I6K17_RS12255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K17_RS12260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K17_RS12280	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K17_RS12285	COG4565	transcriptional regulatory protein
I6K17_RS12290	COG3290	protein histidine kinase activity
I6K17_RS12295	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6K17_RS12305	COG2301	Belongs to the HpcH HpaI aldolase family
I6K17_RS12310	COG3051	citrate lyase alpha subunit
I6K17_RS12325	COG0471	metal ion transport
I6K17_RS12330	COG3719	Belongs to the RNase T2 family
I6K17_RS12335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K17_RS12340	COG0589	response to stress
I6K17_RS12345	COG3634	alkyl hydroperoxide reductase activity
I6K17_RS12350	COG0450	alkyl hydroperoxide reductase
I6K17_RS12355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K17_RS12360	COG0583	DNA-binding transcription factor activity
I6K17_RS12365	COG3969	phosphoadenosine phosphosulfate
I6K17_RS12370	COG1475	DNA binding
I6K17_RS12375	COG0436	Aminotransferase
I6K17_RS12380	COG0371	Dehydrogenase
I6K17_RS12385	COG2879	small protein
I6K17_RS12390	COG1966	Carbon starvation protein
I6K17_RS12395	COG2050	protein possibly involved in aromatic compounds catabolism
I6K17_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS12405	COG3433	isochorismatase activity
I6K17_RS12405	COG1535	isochorismatase
I6K17_RS12410	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K17_RS12415	COG1169	isochorismate synthase
I6K17_RS12420	COG4592	Periplasmic binding protein
I6K17_RS12430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS12435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS12440	COG1120	ATPase activity
I6K17_RS12445	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K17_RS12450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K17_RS12450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K17_RS12455	COG3251	PFAM MbtH domain protein
I6K17_RS12460	COG2382	esterase
I6K17_RS12470	COG2977	Belongs to the P-Pant transferase superfamily
I6K17_RS12500	COG2315	Protein conserved in bacteria
I6K17_RS12505	COG0778	Nitroreductase
I6K17_RS12510	COG0668	transmembrane transport
I6K17_RS12515	COG1113	amino acid transport
I6K17_RS12520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K17_RS12525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS12530	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS12535	COG1538	Outer membrane efflux protein
I6K17_RS12540	COG0745	RESPONSE REGULATOR receiver
I6K17_RS12545	COG5002	protein histidine kinase activity
I6K17_RS12565	COG4571	Outer membrane protease
I6K17_RS12570	COG0500	methyltransferase
I6K17_RS12595	COG2501	S4 domain
I6K17_RS12600	COG1988	membrane-bound metal-dependent
I6K17_RS12610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K17_RS12620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K17_RS12625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K17_RS12630	COG0549	Belongs to the carbamate kinase family
I6K17_RS12640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K17_RS12645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K17_RS12650	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K17_RS12660	COG3257	ureidoglycine aminohydrolase activity
I6K17_RS12665	COG1929	Belongs to the glycerate kinase type-1 family
I6K17_RS12670	COG2233	PERMEase
I6K17_RS12680	COG1953	Uracil, thiamine, allantoin
I6K17_RS12685	COG2084	Dehydrogenase
I6K17_RS12690	COG3622	Belongs to the hyi family
I6K17_RS12695	COG3960	tartronate-semialdehyde synthase activity
I6K17_RS12700	COG1414	Transcriptional regulator
I6K17_RS12720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K17_RS12725	COG4181	ATPase activity
I6K17_RS12730	COG2755	lipolytic protein G-D-S-L family
I6K17_RS12735	COG0300	oxidoreductase activity
I6K17_RS12740	COG3118	belongs to the thioredoxin family
I6K17_RS12745	COG0390	transport system, permease component
I6K17_RS12750	COG4619	ABC transporter
I6K17_RS12755	COG0330	HflC and HflK could
I6K17_RS12760	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K17_RS12785	COG0789	Transcriptional regulator
I6K17_RS12790	COG0531	amino acid
I6K17_RS12800	COG2217	Heavy metal translocating P-type atpase
I6K17_RS12805	COG3093	addiction module antidote protein HigA
I6K17_RS12810	COG3549	Plasmid maintenance system killer
I6K17_RS12815	COG3735	TraB family
I6K17_RS12820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K17_RS12825	COG0737	Belongs to the 5'-nucleotidase family
I6K17_RS12830	COG2223	nitrite transmembrane transporter activity
I6K17_RS12835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K17_RS12835	COG4651	solute:proton antiporter activity
I6K17_RS12840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS12875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K17_RS12885	COG2832	Protein of unknown function (DUF454)
I6K17_RS12890	COG3923	Primosomal replication protein n
I6K17_RS12900	COG3264	Mechanosensitive ion channel
I6K17_RS12900	COG1196	nuclear chromosome segregation
I6K17_RS12905	COG1309	transcriptional regulator
I6K17_RS12910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS12915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K17_RS12930	COG0110	maltose O-acetyltransferase activity
I6K17_RS12940	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K17_RS12945	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K17_RS12955	COG3695	enzyme binding
I6K17_RS12960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K17_RS12965	COG1946	Acyl-CoA thioesterase
I6K17_RS12970	COG0004	ammonium transporteR
I6K17_RS12975	COG0347	Belongs to the P(II) protein family
I6K17_RS12980	COG1132	(ABC) transporter
I6K17_RS12985	COG1132	(ABC) transporter
I6K17_RS12990	COG1522	sequence-specific DNA binding
I6K17_RS13000	COG4533	DNA binding
I6K17_RS13010	COG0824	Thioesterase
I6K17_RS13015	COG1555	photosystem II stabilization
I6K17_RS13020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K17_RS13025	COG0776	regulation of translation
I6K17_RS13030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K17_RS13050	COG0271	Belongs to the BolA IbaG family
I6K17_RS13055	COG3056	Lipoprotein
I6K17_RS13060	COG2223	nitrite transmembrane transporter activity
I6K17_RS13065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K17_RS13070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K17_RS13075	COG1845	cytochrome c oxidase, subunit III
I6K17_RS13080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K17_RS13090	COG2814	Major facilitator Superfamily
I6K17_RS13100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K17_RS13105	COG0693	protein deglycase activity
I6K17_RS13120	COG0142	geranyltranstransferase activity
I6K17_RS13130	COG0667	Aldo Keto reductase
I6K17_RS13135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K17_RS13140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K17_RS13155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K17_RS13155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K17_RS13165	COG4238	major outer membrane lipoprotein
I6K17_RS13170	COG3248	Nucleoside-binding outer membrane protein
I6K17_RS13175	COG1403	HNH endonuclease
I6K17_RS13180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K17_RS13185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K17_RS13190	COG1862	Preprotein translocase
I6K17_RS13210	COG0366	Alpha amylase catalytic
I6K17_RS13215	COG1113	amino acid transport
I6K17_RS13220	COG1114	Component of the transport system for branched-chain amino acids
I6K17_RS13225	COG5002	protein histidine kinase activity
I6K17_RS13230	COG0745	RESPONSE REGULATOR receiver
I6K17_RS13235	COG0420	3'-5' exonuclease activity
I6K17_RS13240	COG0419	ATPase involved in DNA repair
I6K17_RS13245	COG2814	Major facilitator Superfamily
I6K17_RS13250	COG1940	carbohydrate kinase activity
I6K17_RS13275	COG4126	flavin adenine dinucleotide binding
I6K17_RS13295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K17_RS13300	COG3706	GGDEF domain
I6K17_RS13310	COG1785	Belongs to the alkaline phosphatase family
I6K17_RS13325	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K17_RS13345	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K17_RS13350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K17_RS13355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K17_RS13370	COG0113	porphobilinogen synthase activity
I6K17_RS13375	COG2175	clavaminate synthase activity
I6K17_RS13380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K17_RS13390	COG4521	taurine ABC transporter
I6K17_RS13395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K17_RS13400	COG1215	transferase activity, transferring glycosyl groups
I6K17_RS13430	COG3122	Protein conserved in bacteria
I6K17_RS13435	COG2814	Major facilitator Superfamily
I6K17_RS13470	COG1414	Transcriptional regulator
I6K17_RS13475	COG1609	Transcriptional regulator
I6K17_RS13485	COG2223	nitrite transmembrane transporter activity
I6K17_RS13490	COG0110	maltose O-acetyltransferase activity
I6K17_RS13495	COG2807	transmembrane transport
I6K17_RS13505	COG0288	reversible hydration of carbon dioxide
I6K17_RS13510	COG0583	DNA-binding transcription factor activity
I6K17_RS13515	COG0402	S-adenosylhomocysteine deaminase activity
I6K17_RS13520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K17_RS13525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K17_RS13530	COG2079	MmgE PrpD family protein
I6K17_RS13535	COG0372	Belongs to the citrate synthase family
I6K17_RS13540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K17_RS13545	COG3829	transcription factor binding
I6K17_RS13555	COG1280	lysine exporter protein (LysE YggA)
I6K17_RS13565	COG1064	alcohol dehydrogenase
I6K17_RS13575	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS13580	COG1129	ABC transporter
I6K17_RS13585	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS13595	COG0402	S-adenosylhomocysteine deaminase activity
I6K17_RS13600	COG0549	Belongs to the carbamate kinase family
I6K17_RS13610	COG1304	FMN binding
I6K17_RS13615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K17_RS13625	COG0666	response to abiotic stimulus
I6K17_RS13635	COG0583	DNA-binding transcription factor activity
I6K17_RS13640	COG2771	luxR family
I6K17_RS13640	COG2200	EAL domain
I6K17_RS13650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K17_RS13670	COG0582	viral genome integration into host DNA
I6K17_RS13675	COG2200	EAL domain
I6K17_RS13675	COG2771	luxR family
I6K17_RS13690	COG3468	outer membrane autotransporter barrel domain protein
I6K17_RS13700	COG1556	Lactate utilization protein
I6K17_RS13705	COG1139	Iron-sulfur cluster binding protein
I6K17_RS13710	COG0247	lactate metabolic process
I6K17_RS13715	COG2207	Transcriptional regulator
I6K17_RS13720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K17_RS13730	COG3059	membrane
I6K17_RS13735	COG0656	L-ascorbic acid biosynthetic process
I6K17_RS13745	COG4372	Transposase
I6K17_RS13750	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS13765	COG1388	LysM domain
I6K17_RS13770	COG0656	L-ascorbic acid biosynthetic process
I6K17_RS13775	COG0667	Aldo Keto reductase
I6K17_RS13840	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K17_RS13845	COG3477	response to acidic pH
I6K17_RS13870	COG0582	viral genome integration into host DNA
I6K17_RS13895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K17_RS13915	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K17_RS13920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K17_RS13925	COG1690	Belongs to the RtcB family
I6K17_RS13930	COG0454	-acetyltransferase
I6K17_RS13935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K17_RS13950	COG0791	NLP P60 protein
I6K17_RS13955	COG3034	peptidoglycan biosynthetic process
I6K17_RS13960	COG0121	glutamine amidotransferase
I6K17_RS13970	COG1960	acyl-CoA dehydrogenase activity
I6K17_RS13980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K17_RS14050	COG1120	ATPase activity
I6K17_RS14055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS14080	COG0582	viral genome integration into host DNA
I6K17_RS14145	COG2003	Belongs to the UPF0758 family
I6K17_RS14185	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS14205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K17_RS14215	COG2226	methyltransferase
I6K17_RS14220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K17_RS14225	COG0741	lytic transglycosylase activity
I6K17_RS14225	COG1388	LysM domain
I6K17_RS14230	COG2226	methyltransferase
I6K17_RS14240	COG0583	DNA-binding transcription factor activity
I6K17_RS14245	COG0656	L-ascorbic acid biosynthetic process
I6K17_RS14280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K17_RS14285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K17_RS14290	COG2011	ABC-type metal ion transport system permease component
I6K17_RS14295	COG1464	Belongs to the NlpA lipoprotein family
I6K17_RS14305	COG1720	tRNA m6t6A37 methyltransferase activity
I6K17_RS14315	COG0791	NLP P60 protein
I6K17_RS14320	COG3015	lipoprotein NlpE involved in copper resistance
I6K17_RS14325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K17_RS14330	COG4681	YaeQ
I6K17_RS14340	COG4568	rho-dependent transcription termination
I6K17_RS14345	COG0037	tRNA processing
I6K17_RS14350	COG0346	lactoylglutathione lyase activity
I6K17_RS14355	COG1982	Orn Lys Arg decarboxylase major
I6K17_RS14365	COG0587	DNA-directed DNA polymerase activity
I6K17_RS14390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K17_RS14395	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K17_RS14405	COG0750	zinc metalloprotease
I6K17_RS14410	COG0575	Belongs to the CDS family
I6K17_RS14415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K17_RS14420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K17_RS14445	COG0024	Methionine aminopeptidase
I6K17_RS14460	COG1408	metallophosphoesterase
I6K17_RS14470	COG3835	regulator
I6K17_RS14475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K17_RS14490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K17_RS14495	COG2860	membrane
I6K17_RS14520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS14525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K17_RS14530	COG1120	ATPase activity
I6K17_RS14535	COG4774	siderophore transport
I6K17_RS14540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K17_RS14545	COG1643	Atp-dependent helicase
I6K17_RS14550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K17_RS14560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K17_RS14565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K17_RS14570	COG0617	tRNA 3'-terminal CCA addition
I6K17_RS14575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K17_RS14580	COG3539	Fimbrial protein
I6K17_RS14585	COG3121	Chaperone
I6K17_RS14590	COG3188	usher protein
I6K17_RS14595	COG3539	Fimbrial protein
I6K17_RS14600	COG3539	Fimbrial protein
I6K17_RS14605	COG3539	Fimbrial protein
I6K17_RS14610	COG3539	Fimbrial protein
I6K17_RS14620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6K17_RS14625	COG5464	transposase or invertase
I6K17_RS14635	COG0726	polysaccharide deacetylase
I6K17_RS14640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS14645	COG0842	Transport permease protein
I6K17_RS14650	COG1131	(ABC) transporter
I6K17_RS14655	COG0288	reversible hydration of carbon dioxide
I6K17_RS14660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K17_RS14665	COG4993	Dehydrogenase
I6K17_RS14670	COG2132	Multicopper oxidase
I6K17_RS14695	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6K17_RS14700	COG3064	Membrane
I6K17_RS14705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K17_RS14710	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K17_RS14715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K17_RS14720	COG2186	Transcriptional regulator
I6K17_RS14725	COG1113	amino acid transport
I6K17_RS14730	COG3725	Membrane protein required for beta-lactamase induction
I6K17_RS14735	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K17_RS14740	COG0157	Belongs to the NadC ModD family
I6K17_RS14745	COG4969	Belongs to the N-Me-Phe pilin family
I6K17_RS14750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K17_RS14755	COG1459	type II secretion system
I6K17_RS14770	COG0237	dephospho-CoA kinase activity
I6K17_RS14785	COG0494	nUDIX hydrolase
I6K17_RS14805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K17_RS14810	COG0849	cell division
I6K17_RS14815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K17_RS14820	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K17_RS14835	COG0772	Belongs to the SEDS family
I6K17_RS14850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K17_RS14855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K17_RS14860	COG0768	penicillin binding
I6K17_RS14865	COG3116	cell division
I6K17_RS14880	COG1609	Transcriptional regulator
I6K17_RS14890	COG0440	acetolactate synthase activity
I6K17_RS14895	COG0028	Belongs to the TPP enzyme family
I6K17_RS14905	COG0583	DNA-binding transcription factor activity
I6K17_RS14920	COG0473	3-isopropylmalate dehydrogenase activity
I6K17_RS14945	COG4143	(ABC) transporter
I6K17_RS14950	COG1178	ABC-type Fe3 transport system permease component
I6K17_RS14960	COG0586	Pfam SNARE associated Golgi protein
I6K17_RS14965	COG4977	sequence-specific DNA binding
I6K17_RS14980	COG0235	Class ii aldolase
I6K17_RS14985	COG0417	DNA replication proofreading
I6K17_RS14995	COG0564	pseudouridine synthase activity
I6K17_RS15000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K17_RS15010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K17_RS15050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K17_RS15065	COG2271	Major facilitator Superfamily
I6K17_RS15070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K17_RS15075	COG0644	oxidoreductase
I6K17_RS15125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K17_RS15130	COG0505	Belongs to the CarA family
I6K17_RS15150	COG1047	Peptidyl-prolyl cis-trans
I6K17_RS15165	COG0196	riboflavin kinase activity
I6K17_RS15180	COG0583	DNA-binding transcription factor activity
I6K17_RS15210	COG4735	regulation of single-species biofilm formation
I6K17_RS15215	COG1584	GPR1 FUN34 yaaH family protein
I6K17_RS15220	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K17_RS15230	COG1115	amino acid carrier protein
I6K17_RS15245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K17_RS15255	COG0527	aspartate kinase activity
I6K17_RS15255	COG0460	homoserine dehydrogenase
I6K17_RS15265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K17_RS15275	COG0745	RESPONSE REGULATOR receiver
I6K17_RS15280	COG4452	Inner membrane protein CreD
I6K17_RS15285	COG2205	protein histidine kinase activity
I6K17_RS15290	COG0745	RESPONSE REGULATOR receiver
I6K17_RS15295	COG3045	CreA protein
I6K17_RS15300	COG2207	Transcriptional regulator
I6K17_RS15300	COG3708	Transcriptional regulator
I6K17_RS15320	COG0741	lytic transglycosylase activity
I6K17_RS15325	COG0488	(ABC) transporter
I6K17_RS15335	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K17_RS15340	COG3172	ATPase kinase involved in NAD metabolism
I6K17_RS15340	COG1056	cytidyltransferase-related domain
I6K17_RS15345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K17_RS15350	COG0560	Phosphoserine phosphatase
I6K17_RS15355	COG3726	membrane protein affecting hemolysin expression
I6K17_RS15390	COG1328	CTP reductase activity
I6K17_RS15395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K17_RS15400	COG0084	hydrolase, TatD family'
I6K17_RS15405	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K17_RS15415	COG2823	Periplasmic or secreted lipoprotein
I6K17_RS15445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K17_RS15460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K17_RS15470	COG3778	Protein conserved in bacteria
I6K17_RS15475	COG3299	homolog of phage Mu protein gp47
I6K17_RS15495	COG4228	DNA circulation
I6K17_RS15515	COG4386	tail sheath protein
I6K17_RS15560	COG4695	Portal protein
I6K17_RS15570	COG4626	Terminase
I6K17_RS15570	COG1802	Transcriptional regulator
I6K17_RS15610	COG0484	heat shock protein binding
I6K17_RS15615	COG1403	HNH endonuclease
I6K17_RS15625	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K17_RS15635	COG4725	Belongs to the MT-A70-like family
I6K17_RS15645	COG1846	Transcriptional regulator
I6K17_RS15675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K17_RS15680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K17_RS15690	COG1011	Hydrolase
I6K17_RS15695	COG0456	acetyltransferase
I6K17_RS15700	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K17_RS15730	COG4114	ferric iron reductase
I6K17_RS15735	COG2197	response regulator
I6K17_RS15740	COG2197	response regulator
I6K17_RS15745	COG2966	Psort location CytoplasmicMembrane, score
I6K17_RS15760	COG1484	DNA-dependent DNA replication
I6K17_RS15770	COG1368	sulfuric ester hydrolase activity
I6K17_RS15775	COG1063	alcohol dehydrogenase
I6K17_RS15780	COG1802	Transcriptional regulator
I6K17_RS15790	COG0840	transmembrane signaling receptor activity
I6K17_RS15800	COG4145	pantothenate transmembrane transporter activity
I6K17_RS15810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6K17_RS15820	COG1966	Carbon starvation protein
I6K17_RS15825	COG2879	small protein
I6K17_RS15830	COG0523	cobalamin synthesis protein
I6K17_RS15845	COG1715	Restriction endonuclease
I6K17_RS15850	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K17_RS15855	COG0732	type I restriction modification DNA specificity domain
I6K17_RS15860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6K17_RS15870	COG5457	Domain of unknown function (DUF1127)
I6K17_RS15875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K17_RS15885	COG2814	Major facilitator Superfamily
I6K17_RS15890	COG2733	membrane
I6K17_RS15895	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K17_RS15900	COG1924	4 iron, 4 sulfur cluster binding
I6K17_RS15915	COG0477	Major facilitator Superfamily
I6K17_RS15925	COG3366	ferrous iron transmembrane transporter activity
I6K17_RS15930	COG0700	Nucleoside recognition
I6K17_RS15935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K17_RS15940	COG0583	DNA-binding transcription factor activity
I6K17_RS15955	COG2186	Transcriptional regulator
I6K17_RS15960	COG0246	Mannitol dehydrogenase
I6K17_RS15970	COG2610	gluconate transmembrane transporter activity
I6K17_RS15975	COG3539	Fimbrial protein
I6K17_RS15980	COG3539	Fimbrial protein
I6K17_RS15985	COG3539	Fimbrial protein
I6K17_RS15990	COG3188	usher protein
I6K17_RS15995	COG3121	Chaperone
I6K17_RS16000	COG3539	Fimbrial protein
I6K17_RS16010	COG4974	Belongs to the 'phage' integrase family
I6K17_RS16015	COG0582	viral genome integration into host DNA
I6K17_RS16020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K17_RS16090	COG2003	Belongs to the UPF0758 family
I6K17_RS16120	COG2378	regulation of single-species biofilm formation
I6K17_RS16125	COG3596	GTP binding
I6K17_RS16150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K17_RS16215	COG2994	toxin metabolic process
I6K17_RS16275	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K17_RS16310	COG1595	DNA-templated transcription, initiation
I6K17_RS16315	COG3712	iron ion homeostasis
I6K17_RS16320	COG4772	TonB-dependent receptor
I6K17_RS16325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K17_RS16330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS16335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS16340	COG1120	ATPase activity
I6K17_RS16345	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6K17_RS16355	COG2826	transposase and inactivated derivatives, IS30 family
I6K17_RS16370	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS16445	COG2200	EAL domain
I6K17_RS16460	COG0582	viral genome integration into host DNA
I6K17_RS16470	COG1064	alcohol dehydrogenase
I6K17_RS16475	COG0433	COG0433 Predicted ATPase
I6K17_RS16480	COG0795	lipopolysaccharide-transporting ATPase activity
I6K17_RS16485	COG0795	lipopolysaccharide-transporting ATPase activity
I6K17_RS16495	COG2927	DNA polymerase III (CHI subunit)
I6K17_RS16500	COG0525	valine-tRNA ligase activity
I6K17_RS16505	COG4269	membrane
I6K17_RS16510	COG0456	acetyltransferase
I6K17_RS16515	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6K17_RS16530	COG2731	YhcH YjgK YiaL family protein
I6K17_RS16535	COG1309	transcriptional regulator
I6K17_RS16540	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS16545	COG0251	oxidation-reduction process
I6K17_RS16565	COG0251	oxidation-reduction process
I6K17_RS16570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K17_RS16580	COG1609	Transcriptional regulator
I6K17_RS16585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS16585	COG1263	PTS System
I6K17_RS16590	COG0366	Alpha amylase catalytic
I6K17_RS16595	COG1328	CTP reductase activity
I6K17_RS16600	COG0602	queuosine metabolic process
I6K17_RS16605	COG3783	Cytochrome b(562)
I6K17_RS16610	COG0312	modulator of DNA gyrase
I6K17_RS16615	COG3028	Belongs to the UPF0307 family
I6K17_RS16620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K17_RS16630	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS16635	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS16640	COG1129	ABC transporter
I6K17_RS16645	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS16650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K17_RS16655	COG2105	PFAM AIG2 family protein
I6K17_RS16660	COG2911	Protein conserved in bacteria
I6K17_RS16665	COG0729	surface antigen
I6K17_RS16675	COG1253	flavin adenine dinucleotide binding
I6K17_RS16685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K17_RS16695	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6K17_RS16700	COG0737	Belongs to the 5'-nucleotidase family
I6K17_RS16705	COG1733	regulation of RNA biosynthetic process
I6K17_RS16710	COG0702	epimerase
I6K17_RS16715	COG0697	spore germination
I6K17_RS16735	COG1113	amino acid transport
I6K17_RS16740	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K17_RS16745	COG3061	Opacity-associated protein A
I6K17_RS16750	COG1309	transcriptional regulator
I6K17_RS16765	COG1024	Enoyl-CoA hydratase
I6K17_RS16770	COG4670	ketone body catabolic process
I6K17_RS16780	COG2271	Major facilitator Superfamily
I6K17_RS16800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K17_RS16840	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K17_RS16845	COG3037	sugar-specific permease SgaT UlaA
I6K17_RS16860	COG1073	alpha beta
I6K17_RS16865	COG3650	response to hydrogen peroxide
I6K17_RS16875	COG1960	acyl-CoA dehydrogenase activity
I6K17_RS16880	COG0754	glutathionylspermidine amidase activity
I6K17_RS16885	COG5463	Belongs to the UPF0441 family
I6K17_RS16890	COG3766	membrane
I6K17_RS16900	COG1842	Phage shock protein A
I6K17_RS16905	COG3789	protein conserved in bacteria
I6K17_RS16910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K17_RS16915	COG0557	exoribonuclease II activity
I6K17_RS16930	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K17_RS16935	COG0330	HflC and HflK could
I6K17_RS16940	COG0330	HflC and HflK could
I6K17_RS16945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K17_RS16965	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K17_RS16970	COG0802	atpase or kinase
I6K17_RS16975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K17_RS16975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K17_RS17020	COG3264	Mechanosensitive ion channel
I6K17_RS17020	COG1511	domain protein
I6K17_RS17045	COG1053	succinate dehydrogenase
I6K17_RS17050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K17_RS17065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K17_RS17070	COG3040	lipid binding
I6K17_RS17075	COG2076	Multidrug Resistance protein
I6K17_RS17080	COG5510	response to toxic substance
I6K17_RS17085	COG5510	response to toxic substance
I6K17_RS17095	COG1509	lysine 2,3-aminomutase activity
I6K17_RS17120	COG0531	amino acid
I6K17_RS17125	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K17_RS17130	COG1027	Aspartate ammonia-lyase
I6K17_RS17135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K17_RS17145	COG4232	protein-disulfide reductase activity
I6K17_RS17150	COG1309	transcriptional regulator
I6K17_RS17160	COG3710	Transcriptional regulator
I6K17_RS17165	COG0531	amino acid
I6K17_RS17170	COG1982	Orn Lys Arg decarboxylase major
I6K17_RS17175	COG3104	oligopeptide transport
I6K17_RS17180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K17_RS17195	COG2388	GCN5-related N-acetyl-transferase
I6K17_RS17200	COG3592	Divergent 4Fe-4S mono-cluster
I6K17_RS17205	COG3290	protein histidine kinase activity
I6K17_RS17210	COG4565	transcriptional regulatory protein
I6K17_RS17215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K17_RS17220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K17_RS17220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K17_RS17225	COG3647	Membrane
I6K17_RS17230	COG2211	Major facilitator Superfamily
I6K17_RS17235	COG1486	melibiose metabolic process
I6K17_RS17240	COG2169	Transcriptional regulator
I6K17_RS17245	COG1982	Orn Lys Arg decarboxylase major
I6K17_RS17250	COG2207	Transcriptional regulator
I6K17_RS17255	COG0531	amino acid
I6K17_RS17260	COG2194	sulfuric ester hydrolase activity
I6K17_RS17265	COG0745	RESPONSE REGULATOR receiver
I6K17_RS17270	COG0642	Histidine kinase
I6K17_RS17280	COG0477	Major facilitator Superfamily
I6K17_RS17295	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K17_RS17300	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K17_RS17310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K17_RS17315	COG3639	organic phosphonate transmembrane transporter activity
I6K17_RS17320	COG2188	Transcriptional regulator
I6K17_RS17325	COG3624	Phosphonate C-P lyase system protein PhnG
I6K17_RS17330	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K17_RS17335	COG3626	phosphonate metabolism
I6K17_RS17340	COG3627	carbon phosphorus lyase activity
I6K17_RS17345	COG4107	phosphonate C-P lyase system protein PhnK
I6K17_RS17350	COG4778	phosphonate C-P lyase system protein PhnL
I6K17_RS17355	COG3454	Phosphonate metabolism
I6K17_RS17365	COG0456	acetyltransferase
I6K17_RS17370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K17_RS17380	COG0698	ribose 5-phosphate isomerase
I6K17_RS17385	COG1737	Transcriptional regulator
I6K17_RS17390	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS17395	COG1129	ABC transporter
I6K17_RS17400	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS17405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K17_RS17410	COG1940	carbohydrate kinase activity
I6K17_RS17415	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K17_RS17425	COG1566	PFAM secretion protein HlyD family protein
I6K17_RS17430	COG1289	transmembrane transporter activity
I6K17_RS17445	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K17_RS17450	COG1301	dicarboxylic acid transport
I6K17_RS17455	COG4235	cytochrome complex assembly
I6K17_RS17460	COG3088	subunit of a heme lyase
I6K17_RS17465	COG1138	Cytochrome C-type biogenesis protein
I6K17_RS17470	COG3301	Polysulphide reductase, NrfD
I6K17_RS17475	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS17480	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6K17_RS17490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K17_RS17495	COG3162	membrane
I6K17_RS17505	COG0025	NhaP-type Na H and K H
I6K17_RS17510	COG2252	PERMEase
I6K17_RS17515	COG0789	Transcriptional regulator
I6K17_RS17520	COG2207	Transcriptional regulator
I6K17_RS17525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K17_RS17535	COG0629	single-stranded DNA binding
I6K17_RS17540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K17_RS17545	COG2315	Protein conserved in bacteria
I6K17_RS17550	COG0432	Pfam Uncharacterised protein family UPF0047
I6K17_RS17555	COG3700	Belongs to the class B bacterial acid phosphatase family
I6K17_RS17565	COG1448	Aminotransferase
I6K17_RS17570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K17_RS17575	COG0305	Participates in initiation and elongation during chromosome replication
I6K17_RS17580	COG0604	alcohol dehydrogenase
I6K17_RS17590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K17_RS17595	COG0735	belongs to the Fur family
I6K17_RS17600	COG3237	CsbD-like
I6K17_RS17605	COG0534	Mate efflux family protein
I6K17_RS17615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K17_RS17645	COG3842	ATPase activity
I6K17_RS17650	COG2182	Extracellular solute-binding protein
I6K17_RS17655	COG1175	transmembrane transport
I6K17_RS17660	COG3833	ABC-type maltose transport systems, permease component
I6K17_RS17675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K17_RS17700	COG0527	aspartate kinase activity
I6K17_RS17710	COG1187	pseudouridine synthase activity
I6K17_RS17755	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K17_RS17760	COG1410	methionine synthase
I6K17_RS17760	COG0646	methionine synthase
I6K17_RS17765	COG1414	Transcriptional regulator
I6K17_RS17775	COG2224	Isocitrate lyase
I6K17_RS17780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K17_RS17790	COG0456	acetyltransferase
I6K17_RS17820	COG0151	Belongs to the GarS family
I6K17_RS17825	COG2204	response regulator
I6K17_RS17830	COG4191	Histidine kinase
I6K17_RS17835	COG3678	ATP-independent chaperone mediated protein folding
I6K17_RS17850	COG3068	Protein conserved in bacteria
I6K17_RS17885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K17_RS17890	COG2104	thiamine diphosphate biosynthetic process
I6K17_RS17900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K17_RS17935	COG0250	Participates in transcription elongation, termination and antitermination
I6K17_RS17940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K17_RS17975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K17_RS17975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K17_RS18025	COG1309	transcriptional regulator
I6K17_RS18035	COG0583	DNA-binding transcription factor activity
I6K17_RS18040	COG2271	Major facilitator Superfamily
I6K17_RS18045	COG4948	Mandelate Racemase Muconate Lactonizing
I6K17_RS18060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K17_RS18075	COG2194	sulfuric ester hydrolase activity
I6K17_RS18080	COG2207	Transcriptional regulator
I6K17_RS18085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS18090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K17_RS18095	COG1882	Formate acetyltransferase
I6K17_RS18100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS18105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS18110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS18110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS18110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K17_RS18115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K17_RS18120	COG0371	Dehydrogenase
I6K17_RS18125	COG3738	Protein conserved in bacteria
I6K17_RS18130	COG0697	spore germination
I6K17_RS18140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K17_RS18145	COG0737	Belongs to the 5'-nucleotidase family
I6K17_RS18155	COG0737	Belongs to the 5'-nucleotidase family
I6K17_RS18160	COG0737	Belongs to the 5'-nucleotidase family
I6K17_RS18170	COG0460	homoserine dehydrogenase
I6K17_RS18170	COG0527	aspartate kinase activity
I6K17_RS18175	COG0626	cystathionine gamma-synthase activity
I6K17_RS18185	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K17_RS18195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K17_RS18200	COG1609	Transcriptional regulator
I6K17_RS18205	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K17_RS18220	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K17_RS18235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K17_RS18245	COG1494	fructose-1,6-bisphosphatase
I6K17_RS18255	COG0589	response to stress
I6K17_RS18260	COG3691	Protein conserved in bacteria
I6K17_RS18265	COG3152	Membrane
I6K17_RS18285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K17_RS18300	COG3678	ATP-independent chaperone mediated protein folding
I6K17_RS18305	COG0745	RESPONSE REGULATOR receiver
I6K17_RS18310	COG2205	protein histidine kinase activity
I6K17_RS18315	COG2258	MOSC domain
I6K17_RS18325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K17_RS18350	COG4806	L-rhamnose isomerase
I6K17_RS18385	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS18390	COG2864	formate dehydrogenase
I6K17_RS18400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K17_RS18410	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K17_RS18420	COG0456	acetyltransferase
I6K17_RS18435	COG1011	Hydrolase
I6K17_RS18445	COG0477	Major facilitator Superfamily
I6K17_RS18455	COG1063	alcohol dehydrogenase
I6K17_RS18460	COG3684	Belongs to the aldolase LacD family
I6K17_RS18465	COG2084	Dehydrogenase
I6K17_RS18470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS18475	COG1349	DNA-binding transcription factor activity
I6K17_RS18480	COG2271	Major facilitator Superfamily
I6K17_RS18485	COG1082	Xylose isomerase domain protein TIM barrel
I6K17_RS18490	COG2188	Transcriptional regulator
I6K17_RS18495	COG1217	gtp-binding protein TYPA
I6K17_RS18500	COG0174	glutamine synthetase
I6K17_RS18505	COG3852	Histidine kinase
I6K17_RS18510	COG2204	response regulator
I6K17_RS18520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K17_RS18535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K17_RS18535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K17_RS18540	COG0204	Acyl-transferase
I6K17_RS18545	COG5339	Protein conserved in bacteria
I6K17_RS18550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K17_RS18555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K17_RS18560	COG3084	Protein conserved in bacteria
I6K17_RS18565	COG0746	molybdenum cofactor guanylyltransferase activity
I6K17_RS18570	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K17_RS18600	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K17_RS18605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K17_RS18610	COG1739	Uncharacterized protein family UPF0029
I6K17_RS18625	COG0183	Belongs to the thiolase family
I6K17_RS18630	COG0543	2 iron, 2 sulfur cluster binding
I6K17_RS18635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K17_RS18640	COG0250	Participates in transcription elongation, termination and antitermination
I6K17_RS18650	COG0805	protein transport
I6K17_RS18655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K17_RS18660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K17_RS18670	COG3165	ubiquinone biosynthetic process from chorismate
I6K17_RS18680	COG1322	Protein conserved in bacteria
I6K17_RS18685	COG1414	Transcriptional regulator
I6K17_RS18690	COG3734	2-keto-3-deoxy-galactonokinase
I6K17_RS18695	COG0800	Aldolase
I6K17_RS18715	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6K17_RS18720	COG0412	Dienelactone hydrolase
I6K17_RS18725	COG1335	isochorismatase
I6K17_RS18735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K17_RS18740	COG1304	FMN binding
I6K17_RS18745	COG0549	Belongs to the carbamate kinase family
I6K17_RS18755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K17_RS18760	COG0583	DNA-binding transcription factor activity
I6K17_RS18765	COG1737	Transcriptional regulator
I6K17_RS18770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K17_RS18775	COG2190	(PTS) system
I6K17_RS18775	COG1263	PTS System
I6K17_RS18775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS18790	COG0583	DNA-binding transcription factor activity
I6K17_RS18795	COG0697	spore germination
I6K17_RS18800	COG0561	phosphatase activity
I6K17_RS18805	COG2267	carboxylic ester hydrolase activity
I6K17_RS18810	COG1280	lysine exporter protein (LysE YggA)
I6K17_RS18815	COG1280	lysine exporter protein (LysE YggA)
I6K17_RS18820	COG0514	ATP-dependent DNA helicase (RecQ)
I6K17_RS18825	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6K17_RS18830	COG2050	protein possibly involved in aromatic compounds catabolism
I6K17_RS18835	COG2962	Rard protein
I6K17_RS18850	COG0598	Magnesium transport protein CorA
I6K17_RS18855	COG3698	Phosphodiester glycosidase
I6K17_RS18860	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6K17_RS18865	COG0210	DNA helicase
I6K17_RS18870	COG1011	Hydrolase
I6K17_RS18880	COG3159	Protein conserved in bacteria
I6K17_RS18890	COG5567	small periplasmic lipoprotein
I6K17_RS18910	COG3072	Adenylate cyclase
I6K17_RS18920	COG1587	Uroporphyrinogen-III synthase
I6K17_RS18925	COG2959	enzyme of heme biosynthesis
I6K17_RS18930	COG3071	HemY protein
I6K17_RS18935	COG3119	arylsulfatase activity
I6K17_RS18940	COG0641	radical SAM
I6K17_RS18965	COG1113	amino acid transport
I6K17_RS18985	COG2244	polysaccharide biosynthetic process
I6K17_RS18990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K17_RS18995	COG0456	acetyltransferase
I6K17_RS19000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K17_RS19005	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K17_RS19010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K17_RS19015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K17_RS19020	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K17_RS19025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K17_RS19030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K17_RS19040	COG3118	belongs to the thioredoxin family
I6K17_RS19055	COG0210	DNA helicase
I6K17_RS19060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K17_RS19070	COG0583	DNA-binding transcription factor activity
I6K17_RS19075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K17_RS19085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K17_RS19090	COG3978	acetolactate synthase activity
I6K17_RS19110	COG0606	chelatase, subunit chli
I6K17_RS19115	COG3085	chromosome segregation
I6K17_RS19155	COG2186	Transcriptional regulator
I6K17_RS19160	COG0477	Major facilitator Superfamily
I6K17_RS19165	COG1609	Transcriptional regulator
I6K17_RS19170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS19175	COG1879	ABC-type sugar transport system periplasmic component
I6K17_RS19180	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS19185	COG1129	ABC transporter
I6K17_RS19215	COG1522	sequence-specific DNA binding
I6K17_RS19220	COG0716	FMN binding
I6K17_RS19235	COG3312	ion transport
I6K17_RS19310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K17_RS19315	COG0573	inorganic phosphate transmembrane transporter activity
I6K17_RS19320	COG0581	inorganic phosphate transmembrane transporter activity
I6K17_RS19325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K17_RS19330	COG0704	Plays a role in the regulation of phosphate uptake
I6K17_RS19335	COG3711	transcriptional antiterminator
I6K17_RS19340	COG1263	PTS System
I6K17_RS19340	COG2190	(PTS) system
I6K17_RS19340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS19345	COG2723	6-phospho-beta-galactosidase activity
I6K17_RS19355	COG2382	esterase
I6K17_RS19360	COG0363	glucosamine-6-phosphate deaminase activity
I6K17_RS19370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K17_RS19375	COG2252	PERMEase
I6K17_RS19380	COG0431	NADPH-dependent FMN reductase
I6K17_RS19385	COG2091	lysine biosynthetic process via aminoadipic acid
I6K17_RS19390	COG0583	DNA-binding transcription factor activity
I6K17_RS19400	COG0814	amino acid
I6K17_RS19450	COG0592	DNA-directed DNA polymerase activity
I6K17_RS19460	COG0187	DNA topoisomerase II activity
I6K17_RS19465	COG3753	Protein conserved in bacteria
I6K17_RS19470	COG0561	phosphatase activity
I6K17_RS19480	COG2186	Transcriptional regulator
I6K17_RS19485	COG3734	2-keto-3-deoxy-galactonokinase
I6K17_RS19490	COG0800	Aldolase
I6K17_RS19500	COG2271	Major facilitator Superfamily
I6K17_RS19505	COG0644	oxidoreductase
I6K17_RS19510	COG0823	Involved in the tonB-independent uptake of proteins
I6K17_RS19515	COG5645	(Lipo)protein
I6K17_RS19535	COG2207	Transcriptional regulator
I6K17_RS19540	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K17_RS19545	COG3119	arylsulfatase activity
I6K17_RS19550	COG2149	membrane
I6K17_RS19560	COG0641	radical SAM
I6K17_RS19565	COG2814	Major facilitator Superfamily
I6K17_RS19580	COG0028	Belongs to the TPP enzyme family
I6K17_RS19585	COG0440	acetolactate synthase activity
I6K17_RS19590	COG2197	response regulator
I6K17_RS19595	COG3851	Histidine kinase
I6K17_RS19600	COG2271	Major facilitator Superfamily
I6K17_RS19605	COG2271	Major facilitator Superfamily
I6K17_RS19615	COG2252	PERMEase
I6K17_RS19635	COG1464	Belongs to the NlpA lipoprotein family
I6K17_RS19640	COG0697	spore germination
I6K17_RS19680	COG2003	Belongs to the UPF0758 family
I6K17_RS19710	COG2378	regulation of single-species biofilm formation
I6K17_RS19715	COG3596	GTP binding
I6K17_RS19730	COG4372	Transposase
I6K17_RS19735	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS19755	COG4771	TonB-dependent receptor
I6K17_RS19800	COG1609	Transcriptional regulator
I6K17_RS19805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS19815	COG3037	sugar-specific permease SgaT UlaA
I6K17_RS19820	COG3959	Transketolase, thiamine diphosphate binding domain
I6K17_RS19825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6K17_RS19850	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6K17_RS19855	COG1263	PTS System
I6K17_RS19855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS19855	COG2190	(PTS) system
I6K17_RS19875	COG1653	transport
I6K17_RS19895	COG4771	TonB-dependent receptor
I6K17_RS19910	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS19915	COG4372	Transposase
I6K17_RS19920	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS19950	COG0582	viral genome integration into host DNA
I6K17_RS19960	COG2211	Major facilitator Superfamily
I6K17_RS19965	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K17_RS19970	COG3711	transcriptional antiterminator
I6K17_RS19975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS19975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS19975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS19980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS19985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS19985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K17_RS20000	COG1940	carbohydrate kinase activity
I6K17_RS20010	COG2982	Protein involved in outer membrane biogenesis
I6K17_RS20015	COG2233	PERMEase
I6K17_RS20020	COG0786	glutamate:sodium symporter activity
I6K17_RS20025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K17_RS20030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K17_RS20035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K17_RS20045	COG0194	GDP metabolic process
I6K17_RS20055	COG2860	membrane
I6K17_RS20060	COG1561	YicC-like family, N-terminal region
I6K17_RS20085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K17_RS20115	COG1519	Transferase
I6K17_RS20120	COG0859	PFAM glycosyl transferase family 9
I6K17_RS20125	COG0438	transferase activity, transferring glycosyl groups
I6K17_RS20130	COG0515	serine threonine protein kinase
I6K17_RS20145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K17_RS20150	COG1442	glycosyl transferase family 8
I6K17_RS20160	COG3307	-O-antigen
I6K17_RS20165	COG0859	PFAM glycosyl transferase family 9
I6K17_RS20170	COG0859	PFAM glycosyl transferase family 9
I6K17_RS20180	COG0156	8-amino-7-oxononanoate synthase activity
I6K17_RS20190	COG1216	Glycosyl transferase, family 2
I6K17_RS20195	COG2861	carbohydrate metabolic process
I6K17_RS20200	COG4942	peptidase
I6K17_RS20210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K17_RS20215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K17_RS20230	COG1045	serine acetyltransferase
I6K17_RS20235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K17_RS20245	COG2186	Transcriptional regulator
I6K17_RS20250	COG1620	l-lactate permease
I6K17_RS20255	COG5295	Hep Hag repeat protein
I6K17_RS20275	COG3722	fumarate hydratase activity
I6K17_RS20285	COG2213	PTS system mannitol-specific
I6K17_RS20285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS20295	COG1566	PFAM secretion protein HlyD family protein
I6K17_RS20300	COG0625	glutathione transferase activity
I6K17_RS20310	COG3276	selenocysteine insertion sequence binding
I6K17_RS20315	COG1454	alcohol dehydrogenase
I6K17_RS20320	COG1012	belongs to the aldehyde dehydrogenase family
I6K17_RS20335	COG1566	PFAM secretion protein HlyD family protein
I6K17_RS20340	COG0583	DNA-binding transcription factor activity
I6K17_RS20345	COG3713	MltA-interacting MipA family protein
I6K17_RS20355	COG2211	Major facilitator Superfamily
I6K17_RS20365	COG0235	Class ii aldolase
I6K17_RS20370	COG3623	hexulose-6-phosphate isomerase
I6K17_RS20375	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K17_RS20380	COG1070	Carbohydrate kinase
I6K17_RS20385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K17_RS20390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K17_RS20395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K17_RS20400	COG2731	YhcH YjgK YiaL family protein
I6K17_RS20410	COG1414	Transcriptional regulator
I6K17_RS20415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS20420	COG3977	Valine--pyruvate aminotransferase
I6K17_RS20425	COG0366	Alpha amylase catalytic
I6K17_RS20430	COG2992	FlgJ-related protein
I6K17_RS20435	COG1609	Transcriptional regulator
I6K17_RS20435	COG2207	Transcriptional regulator
I6K17_RS20440	COG4214	carbohydrate transport
I6K17_RS20450	COG4213	ABC transporter substrate-binding protein
I6K17_RS20460	COG1070	Carbohydrate kinase
I6K17_RS20465	COG4682	membrane
I6K17_RS20470	COG4682	membrane
I6K17_RS20475	COG3274	enterobacterial common antigen metabolic process
I6K17_RS20500	COG1278	Cold shock
I6K17_RS20505	COG2944	sequence-specific DNA binding
I6K17_RS20520	COG2885	chlorophyll binding
I6K17_RS20525	COG0243	molybdopterin cofactor binding
I6K17_RS20530	COG0456	acetyltransferase
I6K17_RS20535	COG2818	Glycosylase
I6K17_RS20545	COG2223	nitrite transmembrane transporter activity
I6K17_RS20550	COG2194	sulfuric ester hydrolase activity
I6K17_RS20570	COG0747	negative chemotaxis
I6K17_RS20580	COG0601	transmembrane transport
I6K17_RS20585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K17_RS20590	COG0444	Belongs to the ABC transporter superfamily
I6K17_RS20595	COG4608	Belongs to the ABC transporter superfamily
I6K17_RS20600	COG0814	amino acid
I6K17_RS20625	COG2194	sulfuric ester hydrolase activity
I6K17_RS20650	COG1215	transferase activity, transferring glycosyl groups
I6K17_RS20655	COG1215	transferase activity, transferring glycosyl groups
I6K17_RS20660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K17_RS20665	COG3118	belongs to the thioredoxin family
I6K17_RS20665	COG0457	Tetratricopeptide repeat
I6K17_RS20670	COG2200	EAL domain
I6K17_RS20670	COG2199	diguanylate cyclase activity
I6K17_RS20680	COG0612	Peptidase, M16
I6K17_RS20685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS20690	COG2200	EAL domain
I6K17_RS20695	COG2982	Protein involved in outer membrane biogenesis
I6K17_RS20700	COG0477	Major facilitator Superfamily
I6K17_RS20705	COG1295	ribonuclease BN
I6K17_RS20710	COG0583	DNA-binding transcription factor activity
I6K17_RS20715	COG2197	response regulator
I6K17_RS20725	COG1858	cytochrome C peroxidase
I6K17_RS20730	COG0076	glutamate decarboxylase activity
I6K17_RS20740	COG2207	Transcriptional regulator
I6K17_RS20745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K17_RS20750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS20760	COG2771	luxR family
I6K17_RS20765	COG3247	response to pH
I6K17_RS20780	COG1285	pathogenesis
I6K17_RS20790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS20800	COG3721	Heme iron utilization protein
I6K17_RS20810	COG4558	Periplasmic binding protein
I6K17_RS20815	COG4771	TonB-dependent receptor
I6K17_RS20820	COG3720	iron ion transport
I6K17_RS20825	COG2197	response regulator
I6K17_RS20830	COG3065	identical protein binding
I6K17_RS20850	COG1393	Belongs to the ArsC family
I6K17_RS20855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K17_RS20860	COG0640	Transcriptional regulator
I6K17_RS20875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K17_RS20880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K17_RS20885	COG0339	signal peptide processing
I6K17_RS20895	COG3104	oligopeptide transport
I6K17_RS20900	COG0589	response to stress
I6K17_RS20910	COG0306	phosphate transporter
I6K17_RS20915	COG2081	HI0933 family
I6K17_RS20925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS20930	COG0842	Transport permease protein
I6K17_RS20930	COG1129	ABC transporter
I6K17_RS20935	COG0842	Transport permease protein
I6K17_RS20965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K17_RS20970	COG0601	transmembrane transport
I6K17_RS20975	COG0747	negative chemotaxis
I6K17_RS20980	COG2091	lysine biosynthetic process via aminoadipic acid
I6K17_RS20985	COG0628	permease
I6K17_RS20990	COG0477	Major facilitator Superfamily
I6K17_RS21000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K17_RS21015	COG3714	YhhN family
I6K17_RS21025	COG3776	membrane
I6K17_RS21030	COG0742	ribosomal rna small subunit methyltransferase
I6K17_RS21035	COG0552	protein localization to endoplasmic reticulum
I6K17_RS21040	COG2884	Cell division ATP-binding protein ftsE
I6K17_RS21045	COG2177	Part of the ABC transporter FtsEX involved in
I6K17_RS21050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K17_RS21055	COG0683	leucine binding
I6K17_RS21060	COG0456	acetyltransferase
I6K17_RS21065	COG0683	leucine binding
I6K17_RS21070	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K17_RS21075	COG4177	L-phenylalanine transmembrane transporter activity
I6K17_RS21080	COG0411	ABC transporter
I6K17_RS21085	COG0410	ABC transporter
I6K17_RS21100	COG1653	transport
I6K17_RS21105	COG1175	transmembrane transport
I6K17_RS21120	COG0584	glycerophosphoryl diester phosphodiesterase
I6K17_RS21130	COG0405	Gamma-glutamyltransferase
I6K17_RS21135	COG1247	-acetyltransferase
I6K17_RS21140	COG0673	inositol 2-dehydrogenase activity
I6K17_RS21145	COG1741	Belongs to the pirin family
I6K17_RS21150	COG1609	Transcriptional regulator
I6K17_RS21155	COG3265	gluconokinase activity
I6K17_RS21160	COG2610	gluconate transmembrane transporter activity
I6K17_RS21165	COG2095	MarC family integral membrane protein
I6K17_RS21170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K17_RS21175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K17_RS21195	COG0058	SHG alpha-glucan phosphorylase activity
I6K17_RS21205	COG3121	Chaperone
I6K17_RS21210	COG3188	usher protein
I6K17_RS21250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K17_RS21265	COG1349	DNA-binding transcription factor activity
I6K17_RS21270	COG4650	regulator
I6K17_RS21275	COG1690	Belongs to the RtcB family
I6K17_RS21290	COG0058	SHG alpha-glucan phosphorylase activity
I6K17_RS21295	COG1640	4-alpha-glucanotransferase
I6K17_RS21300	COG2610	gluconate transmembrane transporter activity
I6K17_RS21310	COG1040	competence protein
I6K17_RS21320	COG5464	transposase or invertase
I6K17_RS21330	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6K17_RS21335	COG1918	ferrous iron import across plasma membrane
I6K17_RS21340	COG2183	response to ionizing radiation
I6K17_RS21345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K17_RS21375	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K17_RS21385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K17_RS21390	COG1011	Hydrolase
I6K17_RS21400	COG0494	nUDIX hydrolase
I6K17_RS21405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K17_RS21410	COG4972	Pilus assembly protein
I6K17_RS21415	COG3166	PFAM Fimbrial assembly family protein
I6K17_RS21445	COG3266	domain, Protein
I6K17_RS21450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K17_RS21455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K17_RS21465	COG0180	Tryptophanyl-tRNA synthetase
I6K17_RS21470	COG2188	Transcriptional regulator
I6K17_RS21480	COG3457	Alanine racemase
I6K17_RS21485	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6K17_RS21490	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K17_RS21505	COG0626	cystathionine gamma-synthase activity
I6K17_RS21520	COG2116	formate transmembrane transporter activity
I6K17_RS21525	COG2146	nitrite reductase [NAD(P)H] activity
I6K17_RS21530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K17_RS21540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K17_RS21550	COG2184	nucleotidyltransferase activity
I6K17_RS21555	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K17_RS21560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K17_RS21565	COG1289	transmembrane transporter activity
I6K17_RS21570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K17_RS21575	COG1765	OsmC-like protein
I6K17_RS21580	COG3954	Phosphoribulokinase
I6K17_RS21590	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K17_RS21595	COG0488	(ABC) transporter
I6K17_RS21610	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K17_RS21615	COG1047	Peptidyl-prolyl cis-trans
I6K17_RS21625	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K17_RS21630	COG2964	Protein conserved in bacteria
I6K17_RS21670	COG3979	chitinase
I6K17_RS21675	COG2906	2 iron, 2 sulfur cluster binding
I6K17_RS21680	COG2193	ferroxidase activity
I6K17_RS21685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K17_RS21690	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K17_RS21695	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K17_RS21700	COG3156	type II secretion system protein K
I6K17_RS21705	COG4795	General secretion pathway protein
I6K17_RS21710	COG2165	general secretion pathway protein
I6K17_RS21715	COG2165	general secretion pathway protein
I6K17_RS21720	COG2165	general secretion pathway protein
I6K17_RS21725	COG1459	type II secretion system
I6K17_RS21730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K17_RS21735	COG1450	Type ii and iii secretion system protein
I6K17_RS21740	COG3031	protein transport across the cell outer membrane
I6K17_RS21745	COG3267	Type II secretory pathway component ExeA
I6K17_RS21745	COG3409	Peptidoglycan-binding domain 1 protein
I6K17_RS21770	COG0089	rRNA binding
I6K17_RS21860	COG0201	protein transport
I6K17_RS21900	COG0789	Transcriptional regulator
I6K17_RS21905	COG3036	rescue of stalled ribosome
I6K17_RS21915	COG0569	domain protein
I6K17_RS21935	COG0758	DNA mediated transformation
I6K17_RS21945	COG0551	DNA topoisomerase type I activity
I6K17_RS21965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K17_RS22005	COG1126	abc transporter atp-binding protein
I6K17_RS22010	COG0765	amino acid transport
I6K17_RS22015	COG4597	amino acid ABC transporter
I6K17_RS22020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K17_RS22030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K17_RS22035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS22040	COG1309	transcriptional regulator
I6K17_RS22050	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K17_RS22060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K17_RS22070	COG4145	pantothenate transmembrane transporter activity
I6K17_RS22075	COG3924	membrane
I6K17_RS22080	COG0439	Biotin carboxylase
I6K17_RS22085	COG0511	ligase activity, forming carbon-carbon bonds
I6K17_RS22095	COG0604	alcohol dehydrogenase
I6K17_RS22100	COG2199	diguanylate cyclase activity
I6K17_RS22100	COG2200	EAL domain
I6K17_RS22105	COG1077	Cell shape determining protein MreB Mrl
I6K17_RS22110	COG1792	Involved in formation and maintenance of cell shape
I6K17_RS22115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K17_RS22125	COG1530	ribonuclease E activity
I6K17_RS22130	COG3164	Protein of unknown function
I6K17_RS22135	COG0312	modulator of DNA gyrase
I6K17_RS22140	COG0583	DNA-binding transcription factor activity
I6K17_RS22160	COG2732	(Barnase) inhibitor
I6K17_RS22180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K17_RS22185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K17_RS22190	COG3105	Protein conserved in bacteria
I6K17_RS22195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K17_RS22210	COG0625	glutathione transferase activity
I6K17_RS22215	COG2969	positive regulation of protein catabolic process
I6K17_RS22220	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K17_RS22250	COG2731	YhcH YjgK YiaL family protein
I6K17_RS22255	COG4804	nuclease activity
I6K17_RS22260	COG0493	'glutamate synthase
I6K17_RS22265	COG0070	glutamate synthase
I6K17_RS22265	COG0069	glutamate synthase activity
I6K17_RS22265	COG0067	glutamate synthase
I6K17_RS22270	COG1242	4 iron, 4 sulfur cluster binding
I6K17_RS22275	COG5002	protein histidine kinase activity
I6K17_RS22275	COG2198	Histidine kinase
I6K17_RS22275	COG0784	Response regulator, receiver
I6K17_RS22280	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K17_RS22290	COG0515	serine threonine protein kinase
I6K17_RS22295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS22310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K17_RS22315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K17_RS22320	COG1137	ATPase activity
I6K17_RS22325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K17_RS22330	COG3117	lipopolysaccharide transmembrane transporter activity
I6K17_RS22335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K17_RS22340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K17_RS22340	COG0517	IMP dehydrogenase activity
I6K17_RS22345	COG0530	calcium, potassium:sodium antiporter activity
I6K17_RS22350	COG1127	ABC transporter
I6K17_RS22355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K17_RS22360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K17_RS22365	COG2854	intermembrane phospholipid transfer
I6K17_RS22370	COG3113	response to antibiotic
I6K17_RS22375	COG5007	Belongs to the BolA IbaG family
I6K17_RS22385	COG3423	Transcriptional regulator
I6K17_RS22390	COG0142	geranyltranstransferase activity
I6K17_RS22405	COG0697	spore germination
I6K17_RS22415	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K17_RS22420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K17_RS22425	COG1534	Rna-binding protein
I6K17_RS22435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K17_RS22440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K17_RS22450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K17_RS22460	COG2194	sulfuric ester hydrolase activity
I6K17_RS22480	COG0195	Participates in both transcription termination and antitermination
I6K17_RS22520	COG0513	Belongs to the DEAD box helicase family
I6K17_RS22525	COG0814	amino acid
I6K17_RS22530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K17_RS22535	COG0826	peptidase U32
I6K17_RS22540	COG0826	peptidase U32
I6K17_RS22545	COG3154	lipid carrier protein
I6K17_RS22550	COG3153	acetyltransferase
I6K17_RS22565	COG0693	protein deglycase activity
I6K17_RS22570	COG0702	epimerase
I6K17_RS22575	COG0701	Predicted permease
I6K17_RS22580	COG2823	Periplasmic or secreted lipoprotein
I6K17_RS22600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K17_RS22605	COG0363	glucosamine-6-phosphate deaminase activity
I6K17_RS22610	COG3716	PTS system mannose fructose sorbose family IID component
I6K17_RS22615	COG3715	PTS system
I6K17_RS22620	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS22630	COG2222	sugar isomerase
I6K17_RS22635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K17_RS22640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS22645	COG3716	PTS system mannose fructose sorbose family IID component
I6K17_RS22655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS22665	COG1349	DNA-binding transcription factor activity
I6K17_RS22675	COG2002	toxin-antitoxin pair type II binding
I6K17_RS22680	COG2721	sulfolactate sulfo-lyase activity
I6K17_RS22685	COG2271	Major facilitator Superfamily
I6K17_RS22695	COG2084	Dehydrogenase
I6K17_RS22700	COG1929	Belongs to the glycerate kinase type-1 family
I6K17_RS22715	COG0583	DNA-binding transcription factor activity
I6K17_RS22720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K17_RS22730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K17_RS22735	COG1882	Formate acetyltransferase
I6K17_RS22740	COG0251	oxidation-reduction process
I6K17_RS22745	COG1760	l-serine dehydratase
I6K17_RS22750	COG0814	amino acid
I6K17_RS22765	COG1741	Belongs to the pirin family
I6K17_RS22770	COG0583	DNA-binding transcription factor activity
I6K17_RS22775	COG3152	Membrane
I6K17_RS22780	COG3152	Membrane
I6K17_RS22785	COG0435	Glutathione S-transferase
I6K17_RS22790	COG2259	Doxx family
I6K17_RS22800	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K17_RS22805	COG4575	ribosome binding
I6K17_RS22810	COG1422	Protein of unknown function (DUF1090)
I6K17_RS22820	COG0586	Pfam SNARE associated Golgi protein
I6K17_RS22825	COG2186	Transcriptional regulator
I6K17_RS22830	COG2271	Major facilitator Superfamily
I6K17_RS22840	COG2721	sulfolactate sulfo-lyase activity
I6K17_RS22850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6K17_RS22855	COG0861	Integral membrane protein TerC family
I6K17_RS22860	COG0673	inositol 2-dehydrogenase activity
I6K17_RS22865	COG2949	membrane
I6K17_RS22870	COG1451	nucleotide metabolic process
I6K17_RS22885	COG5499	transcription regulator containing HTH domain
I6K17_RS22890	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K17_RS22890	COG1902	pentaerythritol trinitrate reductase activity
I6K17_RS22895	COG3408	Glycogen debranching enzyme
I6K17_RS22895	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K17_RS22905	COG0531	amino acid
I6K17_RS22910	COG2731	YhcH YjgK YiaL family protein
I6K17_RS22915	COG3250	beta-galactosidase activity
I6K17_RS22920	COG1609	Transcriptional regulator
I6K17_RS22925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K17_RS22935	COG0840	transmembrane signaling receptor activity
I6K17_RS22940	COG1695	Transcriptional regulator
I6K17_RS22945	COG2375	cellular response to nickel ion
I6K17_RS22960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K17_RS22965	COG0358	DNA primase activity
I6K17_RS22970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K17_RS22985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K17_RS22990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K17_RS23005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K17_RS23020	COG4991	sh3 domain protein
I6K17_RS23025	COG3025	triphosphatase activity
I6K17_RS23045	COG2268	Band 7 protein
I6K17_RS23050	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K17_RS23080	COG3384	dioxygenase
I6K17_RS23090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K17_RS23100	COG0754	glutathionylspermidine amidase activity
I6K17_RS23110	COG1538	Outer membrane efflux protein
I6K17_RS23115	COG0494	nUDIX hydrolase
I6K17_RS23120	COG3151	Protein conserved in bacteria
I6K17_RS23125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K17_RS23130	COG3150	esterase
I6K17_RS23135	COG0187	DNA topoisomerase II activity
I6K17_RS23155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K17_RS23175	COG2211	Major facilitator Superfamily
I6K17_RS23180	COG4774	siderophore transport
I6K17_RS23185	COG1120	ATPase activity
I6K17_RS23190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS23195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K17_RS23205	COG1737	Transcriptional regulator
I6K17_RS23210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K17_RS23215	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K17_RS23220	COG0642	Histidine kinase
I6K17_RS23225	COG0745	RESPONSE REGULATOR receiver
I6K17_RS23230	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K17_RS23235	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K17_RS23240	COG4166	transmembrane transport
I6K17_RS23245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K17_RS23250	COG0204	Acyl-transferase
I6K17_RS23255	COG2132	Multicopper oxidase
I6K17_RS23260	COG1032	radical SAM domain protein
I6K17_RS23265	COG4238	major outer membrane lipoprotein
I6K17_RS23275	COG0656	L-ascorbic acid biosynthetic process
I6K17_RS23280	COG1979	alcohol dehydrogenase
I6K17_RS23285	COG2207	Transcriptional regulator
I6K17_RS23290	COG0586	Pfam SNARE associated Golgi protein
I6K17_RS23295	COG0626	cystathionine gamma-synthase activity
I6K17_RS23300	COG0811	peptide transport
I6K17_RS23305	COG0848	biopolymer transport protein
I6K17_RS23310	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS23320	COG0667	Aldo Keto reductase
I6K17_RS23335	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K17_RS23340	COG0437	4 iron, 4 sulfur cluster binding
I6K17_RS23345	COG5557	Pfam Polysulphide reductase, NrfD
I6K17_RS23350	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K17_RS23355	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K17_RS23360	COG1773	rubredoxin
I6K17_RS23365	COG0375	protein maturation
I6K17_RS23370	COG0298	carbon dioxide binding
I6K17_RS23375	COG0625	glutathione transferase activity
I6K17_RS23380	COG0754	glutathionylspermidine amidase activity
I6K17_RS23385	COG0306	phosphate transporter
I6K17_RS23390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K17_RS23395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K17_RS23400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K17_RS23405	COG2244	polysaccharide biosynthetic process
I6K17_RS23415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K17_RS23420	COG0795	lipopolysaccharide-transporting ATPase activity
I6K17_RS23430	COG0156	8-amino-7-oxononanoate synthase activity
I6K17_RS23435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K17_RS23450	COG0456	acetyltransferase
I6K17_RS23455	COG2186	Transcriptional regulator
I6K17_RS23460	COG0277	FAD linked oxidase domain protein
I6K17_RS23465	COG0277	FAD linked oxidase domain protein
I6K17_RS23470	COG0247	lactate metabolic process
I6K17_RS23475	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K17_RS23480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K17_RS23485	COG1620	l-lactate permease
I6K17_RS23490	COG3064	Membrane
I6K17_RS23495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K17_RS23515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K17_RS23520	COG1459	type II secretion system
I6K17_RS23525	COG2165	general secretion pathway protein
I6K17_RS23555	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K17_RS23565	COG3609	addiction module antidote protein, CC2985 family
I6K17_RS23600	COG2003	Belongs to the UPF0758 family
I6K17_RS23625	COG3596	GTP binding
I6K17_RS23710	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS23720	COG2271	Major facilitator Superfamily
I6K17_RS23735	COG2964	Protein conserved in bacteria
I6K17_RS23770	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K17_RS23800	COG2194	sulfuric ester hydrolase activity
I6K17_RS23810	COG4584	PFAM Integrase catalytic
I6K17_RS23815	COG1484	DNA-dependent DNA replication
I6K17_RS23865	COG0582	viral genome integration into host DNA
I6K17_RS23890	COG0305	Participates in initiation and elongation during chromosome replication
I6K17_RS23980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K17_RS24000	COG0629	single-stranded DNA binding
I6K17_RS24270	COG0741	lytic transglycosylase activity
I6K17_RS24285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K17_RS24330	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K17_RS24340	COG1811	Na channel or pump
I6K17_RS24345	COG1982	Orn Lys Arg decarboxylase major
I6K17_RS24350	COG2211	Major facilitator Superfamily
I6K17_RS24365	COG1194	a g-specific adenine glycosylase
I6K17_RS24375	COG3171	Protein conserved in bacteria
I6K17_RS24385	COG0252	asparaginase activity
I6K17_RS24400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K17_RS24405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K17_RS24410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K17_RS24425	COG0762	integral membrane protein
I6K17_RS24430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K17_RS24435	COG2805	Type II/IV secretion system protein
I6K17_RS24450	COG0189	ligase activity
I6K17_RS24455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K17_RS24460	COG2356	endonuclease I
I6K17_RS24470	COG2814	Major facilitator Superfamily
I6K17_RS24490	COG1166	arginine decarboxylase activity
I6K17_RS24505	COG0501	Belongs to the peptidase M48B family
I6K17_RS24510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K17_RS24515	COG0330	HflC and HflK could
I6K17_RS24520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K17_RS24525	COG2213	PTS system mannitol-specific
I6K17_RS24530	COG1063	alcohol dehydrogenase
I6K17_RS24535	COG1494	fructose-1,6-bisphosphatase
I6K17_RS24545	COG1072	(Pantothenic acid kinase))
I6K17_RS24560	COG0191	fructose-bisphosphate aldolase activity
I6K17_RS24565	COG0668	transmembrane transport
I6K17_RS24570	COG1279	arginine transmembrane transporter activity
I6K17_RS24575	COG2968	Membrane
I6K17_RS24580	COG0583	DNA-binding transcription factor activity
I6K17_RS24585	COG0427	acetyl-CoA hydrolase
I6K17_RS24590	COG1024	Enoyl-CoA hydratase
I6K17_RS24595	COG1703	isobutyryl-CoA mutase activity
I6K17_RS24600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K17_RS24600	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K17_RS24620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K17_RS24630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K17_RS24650	COG0006	proline dipeptidase activity
I6K17_RS24655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K17_RS24660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K17_RS24685	COG2723	6-phospho-beta-galactosidase activity
I6K17_RS24695	COG1272	protein, Hemolysin III
I6K17_RS24705	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K17_RS24715	COG0716	FMN binding
I6K17_RS24720	COG4974	Belongs to the 'phage' integrase family
I6K17_RS24725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K17_RS24730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K17_RS24740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K17_RS24755	COG2233	PERMEase
I6K17_RS24760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS24760	COG0493	'glutamate synthase
I6K17_RS24765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS24770	COG2252	PERMEase
I6K17_RS24775	COG0402	S-adenosylhomocysteine deaminase activity
I6K17_RS24780	COG2233	PERMEase
I6K17_RS24785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K17_RS24785	COG2080	2 iron, 2 sulfur cluster binding
I6K17_RS24790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K17_RS24795	COG0402	S-adenosylhomocysteine deaminase activity
I6K17_RS24800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS24800	COG0493	'glutamate synthase
I6K17_RS24805	COG2068	MobA-Related Protein
I6K17_RS24810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K17_RS24815	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K17_RS24815	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K17_RS24820	COG0549	Belongs to the carbamate kinase family
I6K17_RS24830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K17_RS24835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K17_RS24840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K17_RS24845	COG3829	transcription factor binding
I6K17_RS24850	COG2080	2 iron, 2 sulfur cluster binding
I6K17_RS24855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K17_RS24860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K17_RS24865	COG4942	peptidase
I6K17_RS24875	COG0814	amino acid
I6K17_RS24880	COG0183	Belongs to the thiolase family
I6K17_RS24890	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS24895	COG2814	Major facilitator Superfamily
I6K17_RS24900	COG1794	racemase activity, acting on amino acids and derivatives
I6K17_RS24905	COG0583	DNA-binding transcription factor activity
I6K17_RS24915	COG1609	Transcriptional regulator
I6K17_RS24930	COG0667	Aldo Keto reductase
I6K17_RS24940	COG0861	Integral membrane protein TerC family
I6K17_RS24955	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6K17_RS24970	COG2165	general secretion pathway protein
I6K17_RS24975	COG4795	General secretion pathway protein
I6K17_RS24985	COG4967	type IV pilus modification protein PilV
I6K17_RS24990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K17_RS25000	COG1074	ATP-dependent DNA helicase activity
I6K17_RS25005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K17_RS25010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K17_RS25010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K17_RS25015	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K17_RS25020	COG3711	transcriptional antiterminator
I6K17_RS25025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K17_RS25025	COG1263	PTS System
I6K17_RS25120	COG2885	chlorophyll binding
I6K17_RS25160	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K17_RS25170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K17_RS25175	COG2166	iron-sulfur cluster assembly
I6K17_RS25180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K17_RS25190	COG0583	DNA-binding transcription factor activity
I6K17_RS25195	COG2363	Small membrane protein
I6K17_RS25205	COG1349	DNA-binding transcription factor activity
I6K17_RS25215	COG1070	Carbohydrate kinase
I6K17_RS25225	COG0738	Major facilitator superfamily
I6K17_RS25230	COG0235	Class ii aldolase
I6K17_RS25235	COG1454	alcohol dehydrogenase
I6K17_RS25245	COG1760	l-serine dehydratase
I6K17_RS25250	COG0814	amino acid
I6K17_RS25255	COG1611	Belongs to the LOG family
I6K17_RS25270	COG3098	single-species biofilm formation
I6K17_RS25275	COG0564	pseudouridine synthase activity
I6K17_RS25280	COG0716	FMN binding
I6K17_RS25285	COG2271	Major facilitator Superfamily
I6K17_RS25290	COG4948	Mandelate Racemase Muconate Lactonizing
I6K17_RS25295	COG4948	Mandelate Racemase Muconate Lactonizing
I6K17_RS25300	COG3437	response regulator, receiver
I6K17_RS25300	COG3850	Histidine kinase
I6K17_RS25300	COG2205	protein histidine kinase activity
I6K17_RS25300	COG4999	Histidine kinase
I6K17_RS25310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K17_RS25315	COG3956	TIGRFAM MazG family protein
I6K17_RS25335	COG0602	queuosine metabolic process
I6K17_RS25340	COG1070	Carbohydrate kinase
I6K17_RS25345	COG2223	nitrite transmembrane transporter activity
I6K17_RS25350	COG1028	Short-chain dehydrogenase reductase Sdr
I6K17_RS25355	COG0277	FAD linked oxidase domain protein
I6K17_RS25365	COG2086	electron transfer activity
I6K17_RS25370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K17_RS25375	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6K17_RS25380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K17_RS25385	COG0644	oxidoreductase
I6K17_RS25390	COG0720	synthase
I6K17_RS25415	COG1203	CRISPR-associated helicase, Cas3
I6K17_RS25430	COG1857	crispr-associated protein
I6K17_RS25445	COG1518	maintenance of DNA repeat elements
I6K17_RS25450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K17_RS25455	COG2234	aminopeptidase activity
I6K17_RS25495	COG0585	pseudouridine synthase activity
I6K17_RS25510	COG1388	LysM domain
I6K17_RS25510	COG4942	peptidase
I6K17_RS25515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K17_RS25525	COG0163	prenyltransferase activity
I6K17_RS25530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K17_RS25540	COG2610	gluconate transmembrane transporter activity
I6K17_RS25545	COG3622	Belongs to the hyi family
I6K17_RS25550	COG0235	Class ii aldolase
I6K17_RS25555	COG3395	kinase activity
I6K17_RS25560	COG2084	Dehydrogenase
I6K17_RS25565	COG1349	DNA-binding transcription factor activity
I6K17_RS25570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K17_RS25595	COG3604	Transcriptional regulator
I6K17_RS25600	COG0309	Hydrogenase expression formation protein (HypE)
I6K17_RS25605	COG0409	Hydrogenase expression formation protein
I6K17_RS25610	COG0298	carbon dioxide binding
I6K17_RS25615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K17_RS25620	COG0375	protein maturation
I6K17_RS25630	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K17_RS25750	COG2826	transposase and inactivated derivatives, IS30 family
I6K17_RS25790	COG3436	PFAM IS66 Orf2 family protein
I6K17_RS25800	COG2072	flavoprotein involved in K transport
I6K17_RS25850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K17_RS25860	COG2819	hydrolase of the alpha beta superfamily
I6K17_RS25865	COG2382	esterase
I6K17_RS25930	COG1538	Outer membrane efflux protein
I6K17_RS25940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K17_RS25955	COG4571	Outer membrane protease
I6K17_RS26010	COG1121	(ABC) transporter
I6K17_RS26015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K17_RS26020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K17_RS26035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6K17_RS26160	COG1475	DNA binding
I6K17_RS26355	COG1475	DNA binding
I6K17_RS26595	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6K17_RS26825	COG0328	RNA-DNA hybrid ribonuclease activity
I6K17_RS26855	COG0237	dephospho-CoA kinase activity
I6K17_RS26870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6K17_RS26880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K17_RS26885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K17_RS26950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6K17_RS27030	COG3121	Chaperone
I6K17_RS27045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K17_RS27170	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K17_RS27205	COG3941	tape measure
I6K17_RS27250	COG5492	domain, Protein
I6K17_RS27250	COG4932	domain protein
I6K17_RS27290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K17_RS27295	COG1475	DNA binding
I6K17_RS27300	COG1475	DNA binding
I6K17_RS27395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair