locus-tag	class	description
I6K18_RS00015	COG3646	Phage regulatory protein
I6K18_RS00025	COG3772	lysozyme
I6K18_RS00095	COG0305	Participates in initiation and elongation during chromosome replication
I6K18_RS00160	COG3723	Recombinational DNA repair protein, rece pathway
I6K18_RS00215	COG0582	viral genome integration into host DNA
I6K18_RS00220	COG4677	pectinesterase activity
I6K18_RS00225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K18_RS00230	COG0471	metal ion transport
I6K18_RS00235	COG2828	Protein conserved in bacteria
I6K18_RS00240	COG0583	DNA-binding transcription factor activity
I6K18_RS00250	COG0561	phosphatase activity
I6K18_RS00255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K18_RS00260	COG4149	molybdate abc transporter
I6K18_RS00265	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K18_RS00275	COG2005	Transcriptional regulator
I6K18_RS00275	COG3585	molybdate ion transport
I6K18_RS00280	COG1119	ATPase activity
I6K18_RS00285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K18_RS00290	COG1085	galactose-1-phosphate uridylyltransferase
I6K18_RS00300	COG2017	converts alpha-aldose to the beta-anomer
I6K18_RS00310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K18_RS00320	COG1230	cation diffusion facilitator family transporter
I6K18_RS00325	COG3201	nicotinamide mononucleotide transporter
I6K18_RS00380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K18_RS00385	COG2885	chlorophyll binding
I6K18_RS00395	COG3064	Membrane
I6K18_RS00400	COG0848	biopolymer transport protein
I6K18_RS00405	COG0811	peptide transport
I6K18_RS00410	COG0824	Thioesterase
I6K18_RS00415	COG3790	cyd operon protein YbgE
I6K18_RS00420	COG4890	Cyd operon protein YbgT
I6K18_RS00425	COG1294	oxidase, subunit
I6K18_RS00430	COG1271	oxidase subunit
I6K18_RS00445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K18_RS00455	COG4865	methylaspartate mutase activity
I6K18_RS00460	COG3799	methylaspartate ammonia-lyase activity
I6K18_RS00475	COG1301	dicarboxylic acid transport
I6K18_RS00480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS00480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS00485	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K18_RS00490	COG0583	DNA-binding transcription factor activity
I6K18_RS00495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K18_RS00505	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K18_RS00510	COG0567	Dehydrogenase, E1 component
I6K18_RS00515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K18_RS00520	COG1053	succinate dehydrogenase
I6K18_RS00525	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K18_RS00530	COG2009	succinate dehydrogenase
I6K18_RS00540	COG0372	Belongs to the citrate synthase family
I6K18_RS00545	COG3539	Fimbrial protein
I6K18_RS00550	COG3188	usher protein
I6K18_RS00555	COG3121	Chaperone
I6K18_RS00560	COG3539	Fimbrial protein
I6K18_RS00565	COG3180	Ammonia monooxygenase
I6K18_RS00580	COG1984	allophanate hydrolase subunit 2
I6K18_RS00585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K18_RS00590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K18_RS00600	COG0415	Belongs to the DNA photolyase family
I6K18_RS00605	COG3272	Protein of unknown function (DUF1722)
I6K18_RS00650	COG2205	protein histidine kinase activity
I6K18_RS00655	COG0745	RESPONSE REGULATOR receiver
I6K18_RS00665	COG0033	Phosphoglucomutase
I6K18_RS00670	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K18_RS00675	COG0596	Alpha beta hydrolase
I6K18_RS00685	COG0716	FMN binding
I6K18_RS00695	COG0735	belongs to the Fur family
I6K18_RS00715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS00715	COG1263	PTS System
I6K18_RS00715	COG2190	(PTS) system
I6K18_RS00725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K18_RS00730	COG1940	carbohydrate kinase activity
I6K18_RS00730	COG1846	Transcriptional regulator
I6K18_RS00735	COG0647	UMP catabolic process
I6K18_RS00740	COG0367	asparagine synthase
I6K18_RS00785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K18_RS00795	COG1702	phosphate starvation-inducible protein PhoH
I6K18_RS00805	COG4535	Mg2 and Co2 transporter CorC
I6K18_RS00810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6K18_RS00815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS00820	COG0765	amino acid transport
I6K18_RS00825	COG0765	amino acid transport
I6K18_RS00830	COG1126	abc transporter atp-binding protein
I6K18_RS00840	COG0443	Heat shock 70 kDa protein
I6K18_RS00845	COG2214	Heat shock protein DnaJ domain protein
I6K18_RS00855	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K18_RS00860	COG2214	Heat shock protein DnaJ domain protein
I6K18_RS00870	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K18_RS00875	COG2888	peptidyl-tyrosine sulfation
I6K18_RS00890	COG1466	dna polymerase III delta subunit
I6K18_RS00900	COG0406	alpha-ribazole phosphatase activity
I6K18_RS00905	COG0799	negative regulation of ribosome biogenesis
I6K18_RS00915	COG0768	penicillin binding
I6K18_RS00920	COG0772	Belongs to the SEDS family
I6K18_RS00925	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K18_RS00930	COG1686	Belongs to the peptidase S11 family
I6K18_RS00945	COG0583	DNA-binding transcription factor activity
I6K18_RS00955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K18_RS00960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K18_RS00980	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K18_RS00985	COG4565	transcriptional regulatory protein
I6K18_RS00990	COG3290	protein histidine kinase activity
I6K18_RS00995	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6K18_RS01005	COG2301	Belongs to the HpcH HpaI aldolase family
I6K18_RS01010	COG3051	citrate lyase alpha subunit
I6K18_RS01025	COG0471	metal ion transport
I6K18_RS01030	COG3719	Belongs to the RNase T2 family
I6K18_RS01035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K18_RS01040	COG0589	response to stress
I6K18_RS01045	COG3634	alkyl hydroperoxide reductase activity
I6K18_RS01050	COG0450	alkyl hydroperoxide reductase
I6K18_RS01055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K18_RS01060	COG0583	DNA-binding transcription factor activity
I6K18_RS01065	COG3969	phosphoadenosine phosphosulfate
I6K18_RS01070	COG1475	DNA binding
I6K18_RS01075	COG0436	Aminotransferase
I6K18_RS01080	COG0371	Dehydrogenase
I6K18_RS01085	COG2879	small protein
I6K18_RS01090	COG1966	Carbon starvation protein
I6K18_RS01100	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS01105	COG3433	isochorismatase activity
I6K18_RS01105	COG1535	isochorismatase
I6K18_RS01110	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K18_RS01115	COG1169	isochorismate synthase
I6K18_RS01120	COG4592	Periplasmic binding protein
I6K18_RS01130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS01135	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS01140	COG1120	ATPase activity
I6K18_RS01145	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K18_RS01150	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K18_RS01150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K18_RS01155	COG3251	PFAM MbtH domain protein
I6K18_RS01160	COG2382	esterase
I6K18_RS01165	COG4771	TonB-dependent receptor
I6K18_RS01170	COG2977	Belongs to the P-Pant transferase superfamily
I6K18_RS01195	COG2315	Protein conserved in bacteria
I6K18_RS01200	COG0778	Nitroreductase
I6K18_RS01205	COG0668	transmembrane transport
I6K18_RS01210	COG1113	amino acid transport
I6K18_RS01215	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K18_RS01220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS01225	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS01230	COG1538	Outer membrane efflux protein
I6K18_RS01235	COG0745	RESPONSE REGULATOR receiver
I6K18_RS01240	COG5002	protein histidine kinase activity
I6K18_RS01290	COG5433	transposase activity
I6K18_RS01315	COG4783	chaperone-mediated protein folding
I6K18_RS01325	COG2207	Transcriptional regulator
I6K18_RS01330	COG4571	Outer membrane protease
I6K18_RS01335	COG2207	Transcriptional regulator
I6K18_RS01360	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS01390	COG1196	nuclear chromosome segregation
I6K18_RS01440	COG1030	water channel activity
I6K18_RS01460	COG4220	transposase activity
I6K18_RS01470	COG5562	phage envelope protein
I6K18_RS01485	COG3772	lysozyme
I6K18_RS01635	COG0582	viral genome integration into host DNA
I6K18_RS01645	COG2197	response regulator
I6K18_RS01650	COG3539	Fimbrial protein
I6K18_RS01655	COG3539	Fimbrial protein
I6K18_RS01660	COG3188	usher protein
I6K18_RS01665	COG3121	Chaperone
I6K18_RS01670	COG3539	Fimbrial protein
I6K18_RS01680	COG2501	S4 domain
I6K18_RS01685	COG1988	membrane-bound metal-dependent
I6K18_RS01695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K18_RS01705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K18_RS01710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K18_RS01715	COG0549	Belongs to the carbamate kinase family
I6K18_RS01725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K18_RS01730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K18_RS01735	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K18_RS01740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K18_RS01745	COG3257	ureidoglycine aminohydrolase activity
I6K18_RS01750	COG1929	Belongs to the glycerate kinase type-1 family
I6K18_RS01755	COG2233	PERMEase
I6K18_RS01765	COG1953	Uracil, thiamine, allantoin
I6K18_RS01770	COG2084	Dehydrogenase
I6K18_RS01775	COG3622	Belongs to the hyi family
I6K18_RS01780	COG3960	tartronate-semialdehyde synthase activity
I6K18_RS01785	COG1414	Transcriptional regulator
I6K18_RS01795	COG0583	DNA-binding transcription factor activity
I6K18_RS01805	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K18_RS01810	COG4181	ATPase activity
I6K18_RS01815	COG2755	lipolytic protein G-D-S-L family
I6K18_RS01820	COG0300	oxidoreductase activity
I6K18_RS01825	COG3118	belongs to the thioredoxin family
I6K18_RS01830	COG0390	transport system, permease component
I6K18_RS01835	COG4619	ABC transporter
I6K18_RS01840	COG0330	HflC and HflK could
I6K18_RS01845	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K18_RS01870	COG0789	Transcriptional regulator
I6K18_RS01895	COG0531	amino acid
I6K18_RS01905	COG2217	Heavy metal translocating P-type atpase
I6K18_RS01910	COG3735	TraB family
I6K18_RS01915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K18_RS01920	COG0737	Belongs to the 5'-nucleotidase family
I6K18_RS01925	COG2223	nitrite transmembrane transporter activity
I6K18_RS01930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K18_RS01930	COG4651	solute:proton antiporter activity
I6K18_RS01935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS01970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K18_RS01980	COG2832	Protein of unknown function (DUF454)
I6K18_RS01985	COG3923	Primosomal replication protein n
I6K18_RS01995	COG3264	Mechanosensitive ion channel
I6K18_RS01995	COG1196	nuclear chromosome segregation
I6K18_RS02000	COG1309	transcriptional regulator
I6K18_RS02005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS02010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K18_RS02025	COG0110	maltose O-acetyltransferase activity
I6K18_RS02035	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K18_RS02040	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K18_RS02050	COG3695	enzyme binding
I6K18_RS02055	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K18_RS02060	COG1946	Acyl-CoA thioesterase
I6K18_RS02065	COG0004	ammonium transporteR
I6K18_RS02070	COG0347	Belongs to the P(II) protein family
I6K18_RS02075	COG1132	(ABC) transporter
I6K18_RS02080	COG1132	(ABC) transporter
I6K18_RS02085	COG1522	sequence-specific DNA binding
I6K18_RS02095	COG4533	DNA binding
I6K18_RS02105	COG0824	Thioesterase
I6K18_RS02110	COG1555	photosystem II stabilization
I6K18_RS02115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K18_RS02120	COG0776	regulation of translation
I6K18_RS02125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K18_RS02145	COG0271	Belongs to the BolA IbaG family
I6K18_RS02150	COG3056	Lipoprotein
I6K18_RS02155	COG2223	nitrite transmembrane transporter activity
I6K18_RS02160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K18_RS02165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K18_RS02170	COG1845	cytochrome c oxidase, subunit III
I6K18_RS02175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K18_RS02185	COG2814	Major facilitator Superfamily
I6K18_RS02195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K18_RS02200	COG0693	protein deglycase activity
I6K18_RS02215	COG0142	geranyltranstransferase activity
I6K18_RS02225	COG0667	Aldo Keto reductase
I6K18_RS02235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K18_RS02240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K18_RS02255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K18_RS02255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K18_RS02265	COG4238	major outer membrane lipoprotein
I6K18_RS02270	COG3248	Nucleoside-binding outer membrane protein
I6K18_RS02275	COG1403	HNH endonuclease
I6K18_RS02280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K18_RS02285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K18_RS02290	COG1862	Preprotein translocase
I6K18_RS02315	COG0366	Alpha amylase catalytic
I6K18_RS02320	COG1113	amino acid transport
I6K18_RS02325	COG1114	Component of the transport system for branched-chain amino acids
I6K18_RS02330	COG5002	protein histidine kinase activity
I6K18_RS02335	COG0745	RESPONSE REGULATOR receiver
I6K18_RS02340	COG0420	3'-5' exonuclease activity
I6K18_RS02345	COG0419	ATPase involved in DNA repair
I6K18_RS02350	COG2814	Major facilitator Superfamily
I6K18_RS02355	COG1940	carbohydrate kinase activity
I6K18_RS02380	COG4126	flavin adenine dinucleotide binding
I6K18_RS02400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K18_RS02405	COG3706	GGDEF domain
I6K18_RS02415	COG1785	Belongs to the alkaline phosphatase family
I6K18_RS02430	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K18_RS02450	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K18_RS02455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K18_RS02460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K18_RS02465	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS02470	COG0113	porphobilinogen synthase activity
I6K18_RS02475	COG2175	clavaminate synthase activity
I6K18_RS02480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K18_RS02485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K18_RS02490	COG4521	taurine ABC transporter
I6K18_RS02495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K18_RS02500	COG1215	transferase activity, transferring glycosyl groups
I6K18_RS02530	COG3122	Protein conserved in bacteria
I6K18_RS02535	COG2814	Major facilitator Superfamily
I6K18_RS02570	COG1414	Transcriptional regulator
I6K18_RS02575	COG1609	Transcriptional regulator
I6K18_RS02585	COG2223	nitrite transmembrane transporter activity
I6K18_RS02590	COG0110	maltose O-acetyltransferase activity
I6K18_RS02595	COG2807	transmembrane transport
I6K18_RS02605	COG0288	reversible hydration of carbon dioxide
I6K18_RS02610	COG0583	DNA-binding transcription factor activity
I6K18_RS02615	COG0402	S-adenosylhomocysteine deaminase activity
I6K18_RS02620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K18_RS02625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K18_RS02630	COG2079	MmgE PrpD family protein
I6K18_RS02635	COG0372	Belongs to the citrate synthase family
I6K18_RS02645	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K18_RS02650	COG3829	transcription factor binding
I6K18_RS02675	COG1064	alcohol dehydrogenase
I6K18_RS02685	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS02690	COG1129	ABC transporter
I6K18_RS02695	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS02705	COG0402	S-adenosylhomocysteine deaminase activity
I6K18_RS02710	COG0549	Belongs to the carbamate kinase family
I6K18_RS02715	COG1304	FMN binding
I6K18_RS02720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K18_RS02730	COG0666	response to abiotic stimulus
I6K18_RS02740	COG0583	DNA-binding transcription factor activity
I6K18_RS02745	COG2200	EAL domain
I6K18_RS02745	COG2771	luxR family
I6K18_RS02750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K18_RS02775	COG1556	Lactate utilization protein
I6K18_RS02780	COG1139	Iron-sulfur cluster binding protein
I6K18_RS02785	COG0247	lactate metabolic process
I6K18_RS02790	COG2207	Transcriptional regulator
I6K18_RS02795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K18_RS02805	COG3059	membrane
I6K18_RS02810	COG0656	L-ascorbic acid biosynthetic process
I6K18_RS02815	COG2207	Transcriptional regulator
I6K18_RS02815	COG3708	Transcriptional regulator
I6K18_RS02820	COG1388	LysM domain
I6K18_RS02825	COG0656	L-ascorbic acid biosynthetic process
I6K18_RS02830	COG0667	Aldo Keto reductase
I6K18_RS02840	COG0583	DNA-binding transcription factor activity
I6K18_RS02845	COG1073	alpha beta
I6K18_RS02850	COG1902	pentaerythritol trinitrate reductase activity
I6K18_RS02910	COG3121	Chaperone
I6K18_RS02915	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K18_RS02920	COG3477	response to acidic pH
I6K18_RS02925	COG2080	2 iron, 2 sulfur cluster binding
I6K18_RS02935	COG3344	reverse transcriptase
I6K18_RS02950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K18_RS02955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K18_RS02960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K18_RS02975	COG0583	DNA-binding transcription factor activity
I6K18_RS03000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K18_RS03020	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K18_RS03035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K18_RS03040	COG1690	Belongs to the RtcB family
I6K18_RS03045	COG0454	-acetyltransferase
I6K18_RS03055	COG2161	toxin-antitoxin pair type II binding
I6K18_RS03070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K18_RS03075	COG1191	sigma factor activity
I6K18_RS03100	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K18_RS03105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K18_RS03130	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K18_RS03155	COG4786	Flagellar basal body rod
I6K18_RS03160	COG4787	bacterial-type flagellum-dependent cell motility
I6K18_RS03165	COG1749	Flagellar hook protein flgE
I6K18_RS03175	COG1558	bacterial-type flagellum-dependent cell motility
I6K18_RS03180	COG1815	bacterial-type flagellum-dependent cell motility
I6K18_RS03210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6K18_RS03230	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K18_RS03240	COG1677	Flagellar hook-basal body complex protein FliE
I6K18_RS03265	COG1987	bacterial-type flagellum assembly
I6K18_RS03290	COG3344	reverse transcriptase
I6K18_RS03300	COG1943	Transposase
I6K18_RS03305	COG0791	NLP P60 protein
I6K18_RS03310	COG3034	peptidoglycan biosynthetic process
I6K18_RS03315	COG0121	glutamine amidotransferase
I6K18_RS03325	COG1960	acyl-CoA dehydrogenase activity
I6K18_RS03335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K18_RS03350	COG5433	transposase activity
I6K18_RS03385	COG3501	Rhs element vgr protein
I6K18_RS03480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K18_RS03490	COG2226	methyltransferase
I6K18_RS03500	COG0741	lytic transglycosylase activity
I6K18_RS03500	COG1388	LysM domain
I6K18_RS03505	COG2226	methyltransferase
I6K18_RS03515	COG0583	DNA-binding transcription factor activity
I6K18_RS03520	COG0656	L-ascorbic acid biosynthetic process
I6K18_RS03555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K18_RS03560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K18_RS03565	COG2011	ABC-type metal ion transport system permease component
I6K18_RS03570	COG1464	Belongs to the NlpA lipoprotein family
I6K18_RS03580	COG1720	tRNA m6t6A37 methyltransferase activity
I6K18_RS03590	COG0791	NLP P60 protein
I6K18_RS03595	COG3015	lipoprotein NlpE involved in copper resistance
I6K18_RS03600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K18_RS03605	COG4681	YaeQ
I6K18_RS03615	COG4568	rho-dependent transcription termination
I6K18_RS03625	COG0346	lactoylglutathione lyase activity
I6K18_RS03630	COG1982	Orn Lys Arg decarboxylase major
I6K18_RS03640	COG0587	DNA-directed DNA polymerase activity
I6K18_RS03665	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K18_RS03670	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K18_RS03680	COG0750	zinc metalloprotease
I6K18_RS03685	COG0575	Belongs to the CDS family
I6K18_RS03690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K18_RS03695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K18_RS03720	COG0024	Methionine aminopeptidase
I6K18_RS03740	COG3835	regulator
I6K18_RS03745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K18_RS03760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K18_RS03765	COG2860	membrane
I6K18_RS03790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS03795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K18_RS03800	COG1120	ATPase activity
I6K18_RS03805	COG4774	siderophore transport
I6K18_RS03810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K18_RS03815	COG1643	Atp-dependent helicase
I6K18_RS03820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K18_RS03830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K18_RS03835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K18_RS03840	COG0617	tRNA 3'-terminal CCA addition
I6K18_RS03845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K18_RS03850	COG3539	Fimbrial protein
I6K18_RS03855	COG3121	Chaperone
I6K18_RS03860	COG3188	usher protein
I6K18_RS03865	COG3539	Fimbrial protein
I6K18_RS03870	COG3539	Fimbrial protein
I6K18_RS03875	COG3539	Fimbrial protein
I6K18_RS03890	COG5464	transposase or invertase
I6K18_RS03900	COG0726	polysaccharide deacetylase
I6K18_RS03905	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS03910	COG0842	Transport permease protein
I6K18_RS03915	COG1131	(ABC) transporter
I6K18_RS03920	COG0288	reversible hydration of carbon dioxide
I6K18_RS03925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K18_RS03930	COG4993	Dehydrogenase
I6K18_RS03935	COG2132	Multicopper oxidase
I6K18_RS03960	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6K18_RS03965	COG3064	Membrane
I6K18_RS03975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K18_RS03980	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K18_RS03985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K18_RS03990	COG2186	Transcriptional regulator
I6K18_RS04000	COG3725	Membrane protein required for beta-lactamase induction
I6K18_RS04005	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K18_RS04010	COG0157	Belongs to the NadC ModD family
I6K18_RS04015	COG4969	Belongs to the N-Me-Phe pilin family
I6K18_RS04020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K18_RS04025	COG1459	type II secretion system
I6K18_RS04040	COG0237	dephospho-CoA kinase activity
I6K18_RS04055	COG0494	nUDIX hydrolase
I6K18_RS04075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K18_RS04080	COG0849	cell division
I6K18_RS04085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K18_RS04090	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K18_RS04105	COG0772	Belongs to the SEDS family
I6K18_RS04120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K18_RS04125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K18_RS04130	COG0768	penicillin binding
I6K18_RS04135	COG3116	cell division
I6K18_RS04150	COG1609	Transcriptional regulator
I6K18_RS04160	COG0440	acetolactate synthase activity
I6K18_RS04165	COG0028	Belongs to the TPP enzyme family
I6K18_RS04175	COG0583	DNA-binding transcription factor activity
I6K18_RS04220	COG4143	(ABC) transporter
I6K18_RS04225	COG1178	ABC-type Fe3 transport system permease component
I6K18_RS04235	COG0586	Pfam SNARE associated Golgi protein
I6K18_RS04240	COG4977	sequence-specific DNA binding
I6K18_RS04255	COG0235	Class ii aldolase
I6K18_RS04260	COG0417	DNA replication proofreading
I6K18_RS04270	COG0564	pseudouridine synthase activity
I6K18_RS04280	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K18_RS04285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K18_RS04290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K18_RS04295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K18_RS04320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K18_RS04335	COG2271	Major facilitator Superfamily
I6K18_RS04340	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K18_RS04345	COG0644	oxidoreductase
I6K18_RS04395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K18_RS04400	COG0505	Belongs to the CarA family
I6K18_RS04420	COG1047	Peptidyl-prolyl cis-trans
I6K18_RS04435	COG0196	riboflavin kinase activity
I6K18_RS04460	COG3121	Chaperone
I6K18_RS04465	COG3188	usher protein
I6K18_RS04475	COG0583	DNA-binding transcription factor activity
I6K18_RS04505	COG4735	regulation of single-species biofilm formation
I6K18_RS04510	COG1584	GPR1 FUN34 yaaH family protein
I6K18_RS04515	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K18_RS04525	COG1115	amino acid carrier protein
I6K18_RS04540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K18_RS04550	COG0527	aspartate kinase activity
I6K18_RS04550	COG0460	homoserine dehydrogenase
I6K18_RS04560	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K18_RS04570	COG0745	RESPONSE REGULATOR receiver
I6K18_RS04575	COG4452	Inner membrane protein CreD
I6K18_RS04580	COG2205	protein histidine kinase activity
I6K18_RS04585	COG0745	RESPONSE REGULATOR receiver
I6K18_RS04590	COG3045	CreA protein
I6K18_RS04595	COG2207	Transcriptional regulator
I6K18_RS04595	COG3708	Transcriptional regulator
I6K18_RS04615	COG0741	lytic transglycosylase activity
I6K18_RS04620	COG0488	(ABC) transporter
I6K18_RS04625	COG0583	DNA-binding transcription factor activity
I6K18_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS04650	COG1902	pentaerythritol trinitrate reductase activity
I6K18_RS04655	COG3172	ATPase kinase involved in NAD metabolism
I6K18_RS04655	COG1056	cytidyltransferase-related domain
I6K18_RS04660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K18_RS04665	COG0560	Phosphoserine phosphatase
I6K18_RS04670	COG3726	membrane protein affecting hemolysin expression
I6K18_RS04705	COG1328	CTP reductase activity
I6K18_RS04710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K18_RS04715	COG0084	hydrolase, TatD family'
I6K18_RS04720	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K18_RS04730	COG2823	Periplasmic or secreted lipoprotein
I6K18_RS04770	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS04895	COG3772	lysozyme
I6K18_RS04925	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K18_RS04935	COG1403	HNH endonuclease
I6K18_RS04945	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K18_RS04955	COG4725	Belongs to the MT-A70-like family
I6K18_RS04965	COG1846	Transcriptional regulator
I6K18_RS04985	COG4197	protein conserved in bacteria, prophage-related
I6K18_RS04990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K18_RS05000	COG5532	Uncharacterized conserved protein (DUF2303)
I6K18_RS05005	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K18_RS05030	COG1011	Hydrolase
I6K18_RS05035	COG0456	acetyltransferase
I6K18_RS05040	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K18_RS05070	COG4114	ferric iron reductase
I6K18_RS05075	COG2197	response regulator
I6K18_RS05080	COG2197	response regulator
I6K18_RS05085	COG2966	Psort location CytoplasmicMembrane, score
I6K18_RS05100	COG1484	DNA-dependent DNA replication
I6K18_RS05115	COG1063	alcohol dehydrogenase
I6K18_RS05120	COG1802	Transcriptional regulator
I6K18_RS05125	COG2271	Major facilitator Superfamily
I6K18_RS05130	COG0840	transmembrane signaling receptor activity
I6K18_RS05135	COG1846	Transcriptional regulator
I6K18_RS05140	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K18_RS05145	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS05150	COG3384	dioxygenase
I6K18_RS05160	COG3971	2-oxopent-4-enoate hydratase activity
I6K18_RS05180	COG2368	4-hydroxyphenylacetate
I6K18_RS05185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K18_RS05190	COG1966	Carbon starvation protein
I6K18_RS05195	COG2879	small protein
I6K18_RS05200	COG0523	cobalamin synthesis protein
I6K18_RS05205	COG1715	Restriction endonuclease
I6K18_RS05210	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6K18_RS05215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6K18_RS05220	COG0732	type I restriction modification DNA specificity domain
I6K18_RS05230	COG1401	restriction endodeoxyribonuclease activity
I6K18_RS05235	COG4268	DNA restriction-modification system
I6K18_RS05245	COG1196	nuclear chromosome segregation
I6K18_RS05255	COG5457	Domain of unknown function (DUF1127)
I6K18_RS05260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K18_RS05270	COG2814	Major facilitator Superfamily
I6K18_RS05275	COG2733	membrane
I6K18_RS05280	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K18_RS05285	COG1924	4 iron, 4 sulfur cluster binding
I6K18_RS05295	COG3204	pilus organization
I6K18_RS05300	COG0477	Major facilitator Superfamily
I6K18_RS05310	COG3366	ferrous iron transmembrane transporter activity
I6K18_RS05315	COG0700	Nucleoside recognition
I6K18_RS05320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K18_RS05325	COG0583	DNA-binding transcription factor activity
I6K18_RS05350	COG2186	Transcriptional regulator
I6K18_RS05355	COG0246	Mannitol dehydrogenase
I6K18_RS05365	COG2610	gluconate transmembrane transporter activity
I6K18_RS05370	COG3539	Fimbrial protein
I6K18_RS05375	COG3539	Fimbrial protein
I6K18_RS05380	COG3539	Fimbrial protein
I6K18_RS05385	COG3188	usher protein
I6K18_RS05390	COG3121	Chaperone
I6K18_RS05395	COG3539	Fimbrial protein
I6K18_RS05400	COG3539	Fimbrial protein
I6K18_RS05405	COG4974	Belongs to the 'phage' integrase family
I6K18_RS05410	COG0582	viral genome integration into host DNA
I6K18_RS05415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K18_RS05420	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6K18_RS05430	COG3039	Transposase
I6K18_RS05450	COG3153	acetyltransferase
I6K18_RS05455	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K18_RS05470	COG1363	Peptidase, m42
I6K18_RS05475	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K18_RS05480	COG3775	system Galactitol-specific IIC component
I6K18_RS05485	COG0434	BtpA family
I6K18_RS05490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS05495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K18_RS05500	COG1349	DNA-binding transcription factor activity
I6K18_RS05505	COG1414	Transcriptional regulator
I6K18_RS05510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K18_RS05515	COG0129	dihydroxy-acid dehydratase activity
I6K18_RS05520	COG2610	gluconate transmembrane transporter activity
I6K18_RS05525	COG2390	Transcriptional regulator
I6K18_RS05565	COG2003	Belongs to the UPF0758 family
I6K18_RS05585	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS05595	COG4983	Phage plasmid primase, P4 family domain protein
I6K18_RS05630	COG3436	PFAM IS66 Orf2 family protein
I6K18_RS05635	COG4372	Transposase
I6K18_RS05670	COG1595	DNA-templated transcription, initiation
I6K18_RS05675	COG3712	iron ion homeostasis
I6K18_RS05680	COG4772	TonB-dependent receptor
I6K18_RS05685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6K18_RS05690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS05695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS05700	COG1120	ATPase activity
I6K18_RS05705	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6K18_RS05720	COG2826	transposase and inactivated derivatives, IS30 family
I6K18_RS05730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K18_RS05760	COG0673	inositol 2-dehydrogenase activity
I6K18_RS05775	COG3385	transposase activity
I6K18_RS05800	COG1064	alcohol dehydrogenase
I6K18_RS05805	COG3265	gluconokinase activity
I6K18_RS05810	COG1063	alcohol dehydrogenase
I6K18_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS05820	COG2610	gluconate transmembrane transporter activity
I6K18_RS05825	COG1609	Transcriptional regulator
I6K18_RS05830	COG0433	COG0433 Predicted ATPase
I6K18_RS05835	COG0795	lipopolysaccharide-transporting ATPase activity
I6K18_RS05840	COG0795	lipopolysaccharide-transporting ATPase activity
I6K18_RS05850	COG2927	DNA polymerase III (CHI subunit)
I6K18_RS05855	COG0525	valine-tRNA ligase activity
I6K18_RS05860	COG4269	membrane
I6K18_RS05865	COG0456	acetyltransferase
I6K18_RS05870	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6K18_RS05895	COG2731	YhcH YjgK YiaL family protein
I6K18_RS05900	COG1309	transcriptional regulator
I6K18_RS05905	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS05910	COG0251	oxidation-reduction process
I6K18_RS05930	COG0251	oxidation-reduction process
I6K18_RS05935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K18_RS05945	COG1609	Transcriptional regulator
I6K18_RS05950	COG1263	PTS System
I6K18_RS05950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS05955	COG0366	Alpha amylase catalytic
I6K18_RS05960	COG1328	CTP reductase activity
I6K18_RS05965	COG0602	queuosine metabolic process
I6K18_RS05970	COG3783	Cytochrome b(562)
I6K18_RS05975	COG0312	modulator of DNA gyrase
I6K18_RS05985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K18_RS05995	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS06000	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS06005	COG1129	ABC transporter
I6K18_RS06010	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS06015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K18_RS06020	COG2105	PFAM AIG2 family protein
I6K18_RS06030	COG3385	transposase activity
I6K18_RS06040	COG0729	surface antigen
I6K18_RS06050	COG1253	flavin adenine dinucleotide binding
I6K18_RS06060	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K18_RS06065	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6K18_RS06070	COG0737	Belongs to the 5'-nucleotidase family
I6K18_RS06075	COG1733	regulation of RNA biosynthetic process
I6K18_RS06080	COG0702	epimerase
I6K18_RS06085	COG0697	spore germination
I6K18_RS06105	COG1113	amino acid transport
I6K18_RS06110	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K18_RS06115	COG3061	Opacity-associated protein A
I6K18_RS06125	COG0675	Transposase, IS605 OrfB family
I6K18_RS06150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K18_RS06185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS06195	COG3037	sugar-specific permease SgaT UlaA
I6K18_RS06210	COG1073	alpha beta
I6K18_RS06215	COG3650	response to hydrogen peroxide
I6K18_RS06225	COG1960	acyl-CoA dehydrogenase activity
I6K18_RS06230	COG0754	glutathionylspermidine amidase activity
I6K18_RS06235	COG5463	Belongs to the UPF0441 family
I6K18_RS06240	COG3766	membrane
I6K18_RS06250	COG1842	Phage shock protein A
I6K18_RS06255	COG3789	protein conserved in bacteria
I6K18_RS06260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K18_RS06265	COG0557	exoribonuclease II activity
I6K18_RS06280	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K18_RS06285	COG0330	HflC and HflK could
I6K18_RS06290	COG0330	HflC and HflK could
I6K18_RS06295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K18_RS06315	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K18_RS06320	COG0802	atpase or kinase
I6K18_RS06325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K18_RS06325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K18_RS06370	COG3264	Mechanosensitive ion channel
I6K18_RS06370	COG1511	domain protein
I6K18_RS06375	COG0531	amino acid
I6K18_RS06385	COG1053	succinate dehydrogenase
I6K18_RS06390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K18_RS06405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K18_RS06410	COG3040	lipid binding
I6K18_RS06415	COG2076	Multidrug Resistance protein
I6K18_RS06420	COG5510	response to toxic substance
I6K18_RS06425	COG5510	response to toxic substance
I6K18_RS06435	COG1509	lysine 2,3-aminomutase activity
I6K18_RS06460	COG0531	amino acid
I6K18_RS06465	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K18_RS06470	COG1027	Aspartate ammonia-lyase
I6K18_RS06475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K18_RS06485	COG4232	protein-disulfide reductase activity
I6K18_RS06490	COG1309	transcriptional regulator
I6K18_RS06500	COG3710	Transcriptional regulator
I6K18_RS06505	COG0531	amino acid
I6K18_RS06510	COG1982	Orn Lys Arg decarboxylase major
I6K18_RS06515	COG3104	oligopeptide transport
I6K18_RS06520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K18_RS06535	COG2388	GCN5-related N-acetyl-transferase
I6K18_RS06540	COG3592	Divergent 4Fe-4S mono-cluster
I6K18_RS06545	COG3290	protein histidine kinase activity
I6K18_RS06550	COG4565	transcriptional regulatory protein
I6K18_RS06555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K18_RS06560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS06560	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS06565	COG3647	Membrane
I6K18_RS06570	COG2211	Major facilitator Superfamily
I6K18_RS06575	COG1486	melibiose metabolic process
I6K18_RS06580	COG2169	Transcriptional regulator
I6K18_RS06585	COG1982	Orn Lys Arg decarboxylase major
I6K18_RS06590	COG2207	Transcriptional regulator
I6K18_RS06595	COG0531	amino acid
I6K18_RS06600	COG2194	sulfuric ester hydrolase activity
I6K18_RS06605	COG0745	RESPONSE REGULATOR receiver
I6K18_RS06610	COG0642	Histidine kinase
I6K18_RS06620	COG0477	Major facilitator Superfamily
I6K18_RS06630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6K18_RS06635	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K18_RS06640	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K18_RS06650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K18_RS06655	COG3639	organic phosphonate transmembrane transporter activity
I6K18_RS06660	COG2188	Transcriptional regulator
I6K18_RS06665	COG3624	Phosphonate C-P lyase system protein PhnG
I6K18_RS06670	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K18_RS06675	COG3626	phosphonate metabolism
I6K18_RS06680	COG3627	carbon phosphorus lyase activity
I6K18_RS06685	COG4107	phosphonate C-P lyase system protein PhnK
I6K18_RS06690	COG4778	phosphonate C-P lyase system protein PhnL
I6K18_RS06695	COG3454	Phosphonate metabolism
I6K18_RS06705	COG0456	acetyltransferase
I6K18_RS06710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K18_RS06720	COG0698	ribose 5-phosphate isomerase
I6K18_RS06725	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K18_RS06735	COG1566	PFAM secretion protein HlyD family protein
I6K18_RS06740	COG1289	transmembrane transporter activity
I6K18_RS06755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K18_RS06760	COG1301	dicarboxylic acid transport
I6K18_RS06765	COG4235	cytochrome complex assembly
I6K18_RS06770	COG3088	subunit of a heme lyase
I6K18_RS06775	COG1138	Cytochrome C-type biogenesis protein
I6K18_RS06780	COG3301	Polysulphide reductase, NrfD
I6K18_RS06785	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS06790	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6K18_RS06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K18_RS06805	COG3162	membrane
I6K18_RS06815	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K18_RS06820	COG0025	NhaP-type Na H and K H
I6K18_RS06825	COG2252	PERMEase
I6K18_RS06830	COG0789	Transcriptional regulator
I6K18_RS06835	COG2207	Transcriptional regulator
I6K18_RS06840	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K18_RS06850	COG0629	single-stranded DNA binding
I6K18_RS06855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K18_RS06860	COG2315	Protein conserved in bacteria
I6K18_RS06865	COG0432	Pfam Uncharacterised protein family UPF0047
I6K18_RS06870	COG3700	Belongs to the class B bacterial acid phosphatase family
I6K18_RS06880	COG1448	Aminotransferase
I6K18_RS06885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K18_RS06890	COG0305	Participates in initiation and elongation during chromosome replication
I6K18_RS06895	COG0604	alcohol dehydrogenase
I6K18_RS06905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K18_RS06915	COG0735	belongs to the Fur family
I6K18_RS06920	COG3237	CsbD-like
I6K18_RS06925	COG0534	Mate efflux family protein
I6K18_RS06935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K18_RS06955	COG1357	PFAM Pentapeptide repeats (8 copies)
I6K18_RS06970	COG3842	ATPase activity
I6K18_RS06975	COG2182	Extracellular solute-binding protein
I6K18_RS06980	COG1175	transmembrane transport
I6K18_RS06985	COG3833	ABC-type maltose transport systems, permease component
I6K18_RS07000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K18_RS07025	COG0527	aspartate kinase activity
I6K18_RS07035	COG1187	pseudouridine synthase activity
I6K18_RS07080	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K18_RS07085	COG0646	methionine synthase
I6K18_RS07085	COG1410	methionine synthase
I6K18_RS07090	COG1414	Transcriptional regulator
I6K18_RS07105	COG2224	Isocitrate lyase
I6K18_RS07110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K18_RS07120	COG0456	acetyltransferase
I6K18_RS07150	COG0151	Belongs to the GarS family
I6K18_RS07155	COG2204	response regulator
I6K18_RS07160	COG4191	Histidine kinase
I6K18_RS07165	COG3678	ATP-independent chaperone mediated protein folding
I6K18_RS07180	COG3068	Protein conserved in bacteria
I6K18_RS07215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K18_RS07220	COG2104	thiamine diphosphate biosynthetic process
I6K18_RS07230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K18_RS07270	COG0250	Participates in transcription elongation, termination and antitermination
I6K18_RS07275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K18_RS07310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K18_RS07310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K18_RS07345	COG4206	TonB-dependent receptor
I6K18_RS07360	COG1309	transcriptional regulator
I6K18_RS07370	COG0583	DNA-binding transcription factor activity
I6K18_RS07385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K18_RS07400	COG2194	sulfuric ester hydrolase activity
I6K18_RS07405	COG2207	Transcriptional regulator
I6K18_RS07410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS07415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K18_RS07420	COG1882	Formate acetyltransferase
I6K18_RS07425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS07430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS07435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K18_RS07435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS07435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS07440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K18_RS07445	COG0371	Dehydrogenase
I6K18_RS07450	COG3738	Protein conserved in bacteria
I6K18_RS07455	COG0697	spore germination
I6K18_RS07465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K18_RS07470	COG0737	Belongs to the 5'-nucleotidase family
I6K18_RS07480	COG0527	aspartate kinase activity
I6K18_RS07480	COG0460	homoserine dehydrogenase
I6K18_RS07485	COG0626	cystathionine gamma-synthase activity
I6K18_RS07495	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K18_RS07505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K18_RS07510	COG1609	Transcriptional regulator
I6K18_RS07515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K18_RS07530	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K18_RS07555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K18_RS07565	COG1494	fructose-1,6-bisphosphatase
I6K18_RS07575	COG0589	response to stress
I6K18_RS07580	COG3691	Protein conserved in bacteria
I6K18_RS07585	COG3152	Membrane
I6K18_RS07605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K18_RS07620	COG3678	ATP-independent chaperone mediated protein folding
I6K18_RS07625	COG0745	RESPONSE REGULATOR receiver
I6K18_RS07630	COG2205	protein histidine kinase activity
I6K18_RS07635	COG2258	MOSC domain
I6K18_RS07645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K18_RS07655	COG1917	Cupin 2, conserved barrel domain protein
I6K18_RS07655	COG4977	sequence-specific DNA binding
I6K18_RS07705	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS07710	COG2864	formate dehydrogenase
I6K18_RS07720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K18_RS07725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K18_RS07735	COG0456	acetyltransferase
I6K18_RS07750	COG1011	Hydrolase
I6K18_RS07755	COG1349	DNA-binding transcription factor activity
I6K18_RS07760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS07765	COG2084	Dehydrogenase
I6K18_RS07770	COG3684	Belongs to the aldolase LacD family
I6K18_RS07775	COG2942	2-epimerase
I6K18_RS07780	COG2017	converts alpha-aldose to the beta-anomer
I6K18_RS07785	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K18_RS07790	COG2211	Major facilitator Superfamily
I6K18_RS07795	COG2211	Major facilitator Superfamily
I6K18_RS07800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K18_RS07805	COG2271	Major facilitator Superfamily
I6K18_RS07825	COG2188	Transcriptional regulator
I6K18_RS07830	COG1217	gtp-binding protein TYPA
I6K18_RS07835	COG0174	glutamine synthetase
I6K18_RS07840	COG3852	Histidine kinase
I6K18_RS07845	COG2204	response regulator
I6K18_RS07855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K18_RS07870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K18_RS07870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K18_RS07875	COG0204	Acyl-transferase
I6K18_RS07880	COG5339	Protein conserved in bacteria
I6K18_RS07885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K18_RS07890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K18_RS07895	COG3084	Protein conserved in bacteria
I6K18_RS07900	COG0746	molybdenum cofactor guanylyltransferase activity
I6K18_RS07905	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K18_RS07935	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K18_RS07940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K18_RS07945	COG1739	Uncharacterized protein family UPF0029
I6K18_RS07960	COG0183	Belongs to the thiolase family
I6K18_RS07965	COG0543	2 iron, 2 sulfur cluster binding
I6K18_RS07970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K18_RS07975	COG0250	Participates in transcription elongation, termination and antitermination
I6K18_RS07985	COG0805	protein transport
I6K18_RS07990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K18_RS07995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K18_RS08005	COG3165	ubiquinone biosynthetic process from chorismate
I6K18_RS08015	COG1322	Protein conserved in bacteria
I6K18_RS08020	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6K18_RS08025	COG0412	Dienelactone hydrolase
I6K18_RS08035	COG0583	DNA-binding transcription factor activity
I6K18_RS08040	COG0697	spore germination
I6K18_RS08045	COG0561	phosphatase activity
I6K18_RS08050	COG2267	carboxylic ester hydrolase activity
I6K18_RS08055	COG1280	lysine exporter protein (LysE YggA)
I6K18_RS08060	COG1280	lysine exporter protein (LysE YggA)
I6K18_RS08065	COG0514	ATP-dependent DNA helicase (RecQ)
I6K18_RS08070	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6K18_RS08075	COG2050	protein possibly involved in aromatic compounds catabolism
I6K18_RS08080	COG2962	Rard protein
I6K18_RS08095	COG0598	Magnesium transport protein CorA
I6K18_RS08100	COG3698	Phosphodiester glycosidase
I6K18_RS08110	COG0210	DNA helicase
I6K18_RS08115	COG1011	Hydrolase
I6K18_RS08125	COG3159	Protein conserved in bacteria
I6K18_RS08135	COG5567	small periplasmic lipoprotein
I6K18_RS08150	COG3072	Adenylate cyclase
I6K18_RS08160	COG1587	Uroporphyrinogen-III synthase
I6K18_RS08165	COG2959	enzyme of heme biosynthesis
I6K18_RS08170	COG3071	HemY protein
I6K18_RS08175	COG3119	arylsulfatase activity
I6K18_RS08180	COG0641	radical SAM
I6K18_RS08205	COG1113	amino acid transport
I6K18_RS08225	COG2244	polysaccharide biosynthetic process
I6K18_RS08230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K18_RS08235	COG0456	acetyltransferase
I6K18_RS08240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K18_RS08245	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K18_RS08250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K18_RS08255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K18_RS08260	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K18_RS08265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K18_RS08270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K18_RS08280	COG3118	belongs to the thioredoxin family
I6K18_RS08295	COG0210	DNA helicase
I6K18_RS08300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K18_RS08310	COG0583	DNA-binding transcription factor activity
I6K18_RS08315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K18_RS08325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K18_RS08330	COG3978	acetolactate synthase activity
I6K18_RS08350	COG0606	chelatase, subunit chli
I6K18_RS08355	COG3085	chromosome segregation
I6K18_RS08395	COG2186	Transcriptional regulator
I6K18_RS08400	COG0477	Major facilitator Superfamily
I6K18_RS08405	COG1609	Transcriptional regulator
I6K18_RS08410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS08415	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS08420	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS08425	COG1129	ABC transporter
I6K18_RS08455	COG1522	sequence-specific DNA binding
I6K18_RS08460	COG0716	FMN binding
I6K18_RS08475	COG3312	ion transport
I6K18_RS08550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K18_RS08555	COG0573	inorganic phosphate transmembrane transporter activity
I6K18_RS08560	COG0581	inorganic phosphate transmembrane transporter activity
I6K18_RS08565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K18_RS08570	COG0704	Plays a role in the regulation of phosphate uptake
I6K18_RS08590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K18_RS08595	COG2252	PERMEase
I6K18_RS08600	COG0431	NADPH-dependent FMN reductase
I6K18_RS08605	COG2091	lysine biosynthetic process via aminoadipic acid
I6K18_RS08620	COG0814	amino acid
I6K18_RS08670	COG0592	DNA-directed DNA polymerase activity
I6K18_RS08680	COG0187	DNA topoisomerase II activity
I6K18_RS08685	COG3753	Protein conserved in bacteria
I6K18_RS08690	COG0561	phosphatase activity
I6K18_RS08700	COG2186	Transcriptional regulator
I6K18_RS08705	COG3734	2-keto-3-deoxy-galactonokinase
I6K18_RS08710	COG0800	Aldolase
I6K18_RS08720	COG2271	Major facilitator Superfamily
I6K18_RS08730	COG0823	Involved in the tonB-independent uptake of proteins
I6K18_RS08735	COG5645	(Lipo)protein
I6K18_RS08755	COG2188	Transcriptional regulator
I6K18_RS08770	COG2207	Transcriptional regulator
I6K18_RS08775	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K18_RS08780	COG3119	arylsulfatase activity
I6K18_RS08790	COG2149	membrane
I6K18_RS08800	COG0641	radical SAM
I6K18_RS08805	COG2814	Major facilitator Superfamily
I6K18_RS08820	COG0028	Belongs to the TPP enzyme family
I6K18_RS08825	COG0440	acetolactate synthase activity
I6K18_RS08840	COG2197	response regulator
I6K18_RS08845	COG3851	Histidine kinase
I6K18_RS08850	COG2271	Major facilitator Superfamily
I6K18_RS08855	COG2271	Major facilitator Superfamily
I6K18_RS08870	COG2252	PERMEase
I6K18_RS08895	COG4932	domain protein
I6K18_RS08895	COG2373	Large extracellular alpha-helical protein
I6K18_RS08895	COG1388	LysM domain
I6K18_RS08920	COG0457	Tetratricopeptide repeat
I6K18_RS08930	COG1464	Belongs to the NlpA lipoprotein family
I6K18_RS08935	COG0697	spore germination
I6K18_RS08940	COG2814	Major facilitator Superfamily
I6K18_RS08955	COG2211	Major facilitator Superfamily
I6K18_RS08965	COG3385	transposase activity
I6K18_RS08975	COG2982	Protein involved in outer membrane biogenesis
I6K18_RS08980	COG2233	PERMEase
I6K18_RS08985	COG0786	glutamate:sodium symporter activity
I6K18_RS08990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K18_RS08995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K18_RS09000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K18_RS09010	COG0194	GDP metabolic process
I6K18_RS09020	COG2860	membrane
I6K18_RS09025	COG3645	SOS response
I6K18_RS09030	COG1561	YicC-like family, N-terminal region
I6K18_RS09055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K18_RS09085	COG1519	Transferase
I6K18_RS09090	COG0859	PFAM glycosyl transferase family 9
I6K18_RS09095	COG0438	transferase activity, transferring glycosyl groups
I6K18_RS09100	COG0515	serine threonine protein kinase
I6K18_RS09110	COG3642	lipopolysaccharide core region biosynthetic process
I6K18_RS09135	COG0859	PFAM glycosyl transferase family 9
I6K18_RS09140	COG0859	PFAM glycosyl transferase family 9
I6K18_RS09155	COG0156	8-amino-7-oxononanoate synthase activity
I6K18_RS09165	COG1216	Glycosyl transferase, family 2
I6K18_RS09170	COG2861	carbohydrate metabolic process
I6K18_RS09175	COG4942	peptidase
I6K18_RS09185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K18_RS09190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K18_RS09205	COG1045	serine acetyltransferase
I6K18_RS09215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K18_RS09225	COG2186	Transcriptional regulator
I6K18_RS09230	COG1620	l-lactate permease
I6K18_RS09235	COG5295	Hep Hag repeat protein
I6K18_RS09255	COG3722	fumarate hydratase activity
I6K18_RS09265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS09265	COG2213	PTS system mannitol-specific
I6K18_RS09275	COG1566	PFAM secretion protein HlyD family protein
I6K18_RS09280	COG0625	glutathione transferase activity
I6K18_RS09290	COG3276	selenocysteine insertion sequence binding
I6K18_RS09295	COG1454	alcohol dehydrogenase
I6K18_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS09310	COG1598	PFAM Uncharacterised protein family UPF0150
I6K18_RS09320	COG2211	Major facilitator Superfamily
I6K18_RS09330	COG0235	Class ii aldolase
I6K18_RS09335	COG3623	hexulose-6-phosphate isomerase
I6K18_RS09340	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K18_RS09345	COG1070	Carbohydrate kinase
I6K18_RS09350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K18_RS09355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K18_RS09360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K18_RS09365	COG2731	YhcH YjgK YiaL family protein
I6K18_RS09375	COG1414	Transcriptional regulator
I6K18_RS09380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS09385	COG3977	Valine--pyruvate aminotransferase
I6K18_RS09390	COG0366	Alpha amylase catalytic
I6K18_RS09395	COG2992	FlgJ-related protein
I6K18_RS09400	COG2207	Transcriptional regulator
I6K18_RS09400	COG1609	Transcriptional regulator
I6K18_RS09405	COG4214	carbohydrate transport
I6K18_RS09415	COG4213	ABC transporter substrate-binding protein
I6K18_RS09425	COG1070	Carbohydrate kinase
I6K18_RS09430	COG4682	membrane
I6K18_RS09435	COG4682	membrane
I6K18_RS09440	COG3274	enterobacterial common antigen metabolic process
I6K18_RS09465	COG1278	Cold shock
I6K18_RS09470	COG2944	sequence-specific DNA binding
I6K18_RS09485	COG2885	chlorophyll binding
I6K18_RS09490	COG0243	molybdopterin cofactor binding
I6K18_RS09495	COG0456	acetyltransferase
I6K18_RS09500	COG2818	Glycosylase
I6K18_RS09505	COG5571	outer membrane autotransporter
I6K18_RS09510	COG2223	nitrite transmembrane transporter activity
I6K18_RS09515	COG2194	sulfuric ester hydrolase activity
I6K18_RS09530	COG0747	negative chemotaxis
I6K18_RS09535	COG0601	transmembrane transport
I6K18_RS09540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K18_RS09545	COG0444	Belongs to the ABC transporter superfamily
I6K18_RS09550	COG4608	Belongs to the ABC transporter superfamily
I6K18_RS09555	COG0814	amino acid
I6K18_RS09570	COG2194	sulfuric ester hydrolase activity
I6K18_RS09605	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K18_RS09615	COG2199	diguanylate cyclase activity
I6K18_RS09615	COG2200	EAL domain
I6K18_RS09625	COG0612	Peptidase, M16
I6K18_RS09660	COG2200	EAL domain
I6K18_RS09665	COG2982	Protein involved in outer membrane biogenesis
I6K18_RS09670	COG0477	Major facilitator Superfamily
I6K18_RS09675	COG1295	ribonuclease BN
I6K18_RS09680	COG0583	DNA-binding transcription factor activity
I6K18_RS09685	COG2197	response regulator
I6K18_RS09695	COG1858	cytochrome C peroxidase
I6K18_RS09700	COG0076	glutamate decarboxylase activity
I6K18_RS09705	COG2207	Transcriptional regulator
I6K18_RS09710	COG2207	Transcriptional regulator
I6K18_RS09715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K18_RS09720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS09730	COG2771	luxR family
I6K18_RS09735	COG3247	response to pH
I6K18_RS09750	COG1285	pathogenesis
I6K18_RS09760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS09770	COG3721	Heme iron utilization protein
I6K18_RS09780	COG4558	Periplasmic binding protein
I6K18_RS09785	COG4771	TonB-dependent receptor
I6K18_RS09790	COG3720	iron ion transport
I6K18_RS09795	COG2197	response regulator
I6K18_RS09800	COG3065	identical protein binding
I6K18_RS09820	COG1393	Belongs to the ArsC family
I6K18_RS09825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K18_RS09840	COG0640	Transcriptional regulator
I6K18_RS09855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K18_RS09860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K18_RS09865	COG0339	signal peptide processing
I6K18_RS09875	COG3104	oligopeptide transport
I6K18_RS09880	COG0589	response to stress
I6K18_RS09890	COG0306	phosphate transporter
I6K18_RS09895	COG2081	HI0933 family
I6K18_RS09915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS09920	COG0842	Transport permease protein
I6K18_RS09920	COG1129	ABC transporter
I6K18_RS09925	COG0842	Transport permease protein
I6K18_RS09930	COG0191	fructose-bisphosphate aldolase activity
I6K18_RS09945	COG3775	system Galactitol-specific IIC component
I6K18_RS09950	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K18_RS09960	COG2188	Transcriptional regulator
I6K18_RS09980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K18_RS09985	COG0601	transmembrane transport
I6K18_RS09990	COG0747	negative chemotaxis
I6K18_RS09995	COG2091	lysine biosynthetic process via aminoadipic acid
I6K18_RS10000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K18_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS10015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K18_RS10040	COG1216	Glycosyl transferase, family 2
I6K18_RS10060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K18_RS10070	COG0204	Acyl-transferase
I6K18_RS10090	COG0628	permease
I6K18_RS10095	COG0477	Major facilitator Superfamily
I6K18_RS10105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K18_RS10125	COG3714	YhhN family
I6K18_RS10135	COG3776	membrane
I6K18_RS10140	COG0742	ribosomal rna small subunit methyltransferase
I6K18_RS10145	COG0552	protein localization to endoplasmic reticulum
I6K18_RS10150	COG2884	Cell division ATP-binding protein ftsE
I6K18_RS10155	COG2177	Part of the ABC transporter FtsEX involved in
I6K18_RS10160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K18_RS10165	COG0683	leucine binding
I6K18_RS10170	COG0456	acetyltransferase
I6K18_RS10175	COG0683	leucine binding
I6K18_RS10180	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS10185	COG4177	L-phenylalanine transmembrane transporter activity
I6K18_RS10190	COG0411	ABC transporter
I6K18_RS10195	COG0410	ABC transporter
I6K18_RS10200	COG1653	transport
I6K18_RS10205	COG1175	transmembrane transport
I6K18_RS10220	COG0584	glycerophosphoryl diester phosphodiesterase
I6K18_RS10230	COG0405	Gamma-glutamyltransferase
I6K18_RS10250	COG3157	Type VI secretion system effector, Hcp
I6K18_RS10255	COG1247	-acetyltransferase
I6K18_RS10260	COG0673	inositol 2-dehydrogenase activity
I6K18_RS10265	COG1741	Belongs to the pirin family
I6K18_RS10270	COG1609	Transcriptional regulator
I6K18_RS10275	COG3265	gluconokinase activity
I6K18_RS10280	COG2610	gluconate transmembrane transporter activity
I6K18_RS10285	COG2095	MarC family integral membrane protein
I6K18_RS10290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K18_RS10295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K18_RS10315	COG0058	SHG alpha-glucan phosphorylase activity
I6K18_RS10325	COG3121	Chaperone
I6K18_RS10330	COG3188	usher protein
I6K18_RS10335	COG3539	Fimbrial protein
I6K18_RS10345	COG3121	Chaperone
I6K18_RS10355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K18_RS10370	COG1349	DNA-binding transcription factor activity
I6K18_RS10375	COG4650	regulator
I6K18_RS10380	COG1690	Belongs to the RtcB family
I6K18_RS10395	COG0058	SHG alpha-glucan phosphorylase activity
I6K18_RS10400	COG1640	4-alpha-glucanotransferase
I6K18_RS10405	COG2610	gluconate transmembrane transporter activity
I6K18_RS10425	COG5464	transposase or invertase
I6K18_RS10435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6K18_RS10440	COG1918	ferrous iron import across plasma membrane
I6K18_RS10445	COG2183	response to ionizing radiation
I6K18_RS10450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K18_RS10470	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K18_RS10480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K18_RS10485	COG1011	Hydrolase
I6K18_RS10495	COG0494	nUDIX hydrolase
I6K18_RS10500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K18_RS10505	COG4972	Pilus assembly protein
I6K18_RS10510	COG3166	PFAM Fimbrial assembly family protein
I6K18_RS10525	COG4796	Type ii and iii secretion system protein
I6K18_RS10540	COG3266	domain, Protein
I6K18_RS10545	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K18_RS10550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K18_RS10560	COG0180	Tryptophanyl-tRNA synthetase
I6K18_RS10565	COG2188	Transcriptional regulator
I6K18_RS10575	COG3457	Alanine racemase
I6K18_RS10580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6K18_RS10585	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K18_RS10600	COG0626	cystathionine gamma-synthase activity
I6K18_RS10615	COG2116	formate transmembrane transporter activity
I6K18_RS10620	COG2146	nitrite reductase [NAD(P)H] activity
I6K18_RS10625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K18_RS10635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K18_RS10645	COG2184	nucleotidyltransferase activity
I6K18_RS10650	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K18_RS10655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K18_RS10660	COG1289	transmembrane transporter activity
I6K18_RS10665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K18_RS10670	COG1765	OsmC-like protein
I6K18_RS10675	COG3954	Phosphoribulokinase
I6K18_RS10685	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K18_RS10690	COG0488	(ABC) transporter
I6K18_RS10705	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K18_RS10710	COG1047	Peptidyl-prolyl cis-trans
I6K18_RS10720	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K18_RS10725	COG2964	Protein conserved in bacteria
I6K18_RS10795	COG0089	rRNA binding
I6K18_RS10885	COG0201	protein transport
I6K18_RS10925	COG0789	Transcriptional regulator
I6K18_RS10930	COG3036	rescue of stalled ribosome
I6K18_RS10940	COG0569	domain protein
I6K18_RS10960	COG0758	DNA mediated transformation
I6K18_RS10970	COG0551	DNA topoisomerase type I activity
I6K18_RS10990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K18_RS11030	COG1126	abc transporter atp-binding protein
I6K18_RS11035	COG0765	amino acid transport
I6K18_RS11040	COG4597	amino acid ABC transporter
I6K18_RS11045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS11055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K18_RS11060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS11065	COG1309	transcriptional regulator
I6K18_RS11075	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K18_RS11085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K18_RS11095	COG4145	pantothenate transmembrane transporter activity
I6K18_RS11100	COG3924	membrane
I6K18_RS11105	COG0439	Biotin carboxylase
I6K18_RS11110	COG0511	ligase activity, forming carbon-carbon bonds
I6K18_RS11120	COG0604	alcohol dehydrogenase
I6K18_RS11125	COG2200	EAL domain
I6K18_RS11125	COG2199	diguanylate cyclase activity
I6K18_RS11130	COG1077	Cell shape determining protein MreB Mrl
I6K18_RS11135	COG1792	Involved in formation and maintenance of cell shape
I6K18_RS11140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K18_RS11150	COG1530	ribonuclease E activity
I6K18_RS11155	COG3164	Protein of unknown function
I6K18_RS11160	COG0312	modulator of DNA gyrase
I6K18_RS11165	COG0583	DNA-binding transcription factor activity
I6K18_RS11185	COG2732	(Barnase) inhibitor
I6K18_RS11205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K18_RS11210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K18_RS11215	COG3105	Protein conserved in bacteria
I6K18_RS11220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K18_RS11235	COG0625	glutathione transferase activity
I6K18_RS11240	COG2969	positive regulation of protein catabolic process
I6K18_RS11245	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K18_RS11275	COG2731	YhcH YjgK YiaL family protein
I6K18_RS11280	COG4804	nuclease activity
I6K18_RS11285	COG0493	'glutamate synthase
I6K18_RS11290	COG0067	glutamate synthase
I6K18_RS11290	COG0070	glutamate synthase
I6K18_RS11290	COG0069	glutamate synthase activity
I6K18_RS11295	COG1242	4 iron, 4 sulfur cluster binding
I6K18_RS11300	COG0784	Response regulator, receiver
I6K18_RS11300	COG5002	protein histidine kinase activity
I6K18_RS11300	COG2198	Histidine kinase
I6K18_RS11305	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K18_RS11315	COG0515	serine threonine protein kinase
I6K18_RS11320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS11335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K18_RS11340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K18_RS11345	COG1137	ATPase activity
I6K18_RS11350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K18_RS11355	COG3117	lipopolysaccharide transmembrane transporter activity
I6K18_RS11360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K18_RS11365	COG0517	IMP dehydrogenase activity
I6K18_RS11365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K18_RS11370	COG0530	calcium, potassium:sodium antiporter activity
I6K18_RS11375	COG1127	ABC transporter
I6K18_RS11380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K18_RS11385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K18_RS11390	COG2854	intermembrane phospholipid transfer
I6K18_RS11395	COG3113	response to antibiotic
I6K18_RS11400	COG5007	Belongs to the BolA IbaG family
I6K18_RS11410	COG3423	Transcriptional regulator
I6K18_RS11415	COG0142	geranyltranstransferase activity
I6K18_RS11430	COG0697	spore germination
I6K18_RS11440	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K18_RS11445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K18_RS11450	COG1534	Rna-binding protein
I6K18_RS11460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K18_RS11465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K18_RS11475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K18_RS11485	COG2194	sulfuric ester hydrolase activity
I6K18_RS11505	COG0195	Participates in both transcription termination and antitermination
I6K18_RS11545	COG0513	Belongs to the DEAD box helicase family
I6K18_RS11550	COG0814	amino acid
I6K18_RS11560	COG3034	peptidoglycan biosynthetic process
I6K18_RS11565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K18_RS11570	COG0826	peptidase U32
I6K18_RS11575	COG0826	peptidase U32
I6K18_RS11580	COG3154	lipid carrier protein
I6K18_RS11585	COG3153	acetyltransferase
I6K18_RS11600	COG0693	protein deglycase activity
I6K18_RS11605	COG0702	epimerase
I6K18_RS11610	COG0701	Predicted permease
I6K18_RS11615	COG2823	Periplasmic or secreted lipoprotein
I6K18_RS11635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K18_RS11640	COG0363	glucosamine-6-phosphate deaminase activity
I6K18_RS11645	COG3716	PTS system mannose fructose sorbose family IID component
I6K18_RS11650	COG3715	PTS system
I6K18_RS11655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS11665	COG2222	sugar isomerase
I6K18_RS11670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K18_RS11675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS11680	COG3716	PTS system mannose fructose sorbose family IID component
I6K18_RS11690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS11700	COG1349	DNA-binding transcription factor activity
I6K18_RS11710	COG2002	toxin-antitoxin pair type II binding
I6K18_RS11715	COG2721	sulfolactate sulfo-lyase activity
I6K18_RS11720	COG2271	Major facilitator Superfamily
I6K18_RS11730	COG2084	Dehydrogenase
I6K18_RS11735	COG1929	Belongs to the glycerate kinase type-1 family
I6K18_RS11760	COG0583	DNA-binding transcription factor activity
I6K18_RS11765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K18_RS11780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K18_RS11785	COG1882	Formate acetyltransferase
I6K18_RS11790	COG0251	oxidation-reduction process
I6K18_RS11795	COG1760	l-serine dehydratase
I6K18_RS11800	COG0814	amino acid
I6K18_RS11815	COG1741	Belongs to the pirin family
I6K18_RS11820	COG0583	DNA-binding transcription factor activity
I6K18_RS11825	COG3152	Membrane
I6K18_RS11830	COG3152	Membrane
I6K18_RS11835	COG0435	Glutathione S-transferase
I6K18_RS11840	COG2259	Doxx family
I6K18_RS11850	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K18_RS11855	COG4575	ribosome binding
I6K18_RS11860	COG1422	Protein of unknown function (DUF1090)
I6K18_RS11870	COG0586	Pfam SNARE associated Golgi protein
I6K18_RS11875	COG2186	Transcriptional regulator
I6K18_RS11880	COG2271	Major facilitator Superfamily
I6K18_RS11890	COG2721	sulfolactate sulfo-lyase activity
I6K18_RS11900	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6K18_RS11905	COG0861	Integral membrane protein TerC family
I6K18_RS11910	COG0673	inositol 2-dehydrogenase activity
I6K18_RS11915	COG2949	membrane
I6K18_RS11920	COG1451	nucleotide metabolic process
I6K18_RS11930	COG4680	protein conserved in bacteria
I6K18_RS11935	COG5499	transcription regulator containing HTH domain
I6K18_RS11940	COG1902	pentaerythritol trinitrate reductase activity
I6K18_RS11940	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K18_RS11945	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K18_RS11945	COG3408	Glycogen debranching enzyme
I6K18_RS11955	COG0531	amino acid
I6K18_RS11960	COG2731	YhcH YjgK YiaL family protein
I6K18_RS11965	COG3250	beta-galactosidase activity
I6K18_RS11970	COG1609	Transcriptional regulator
I6K18_RS11975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K18_RS11985	COG0840	transmembrane signaling receptor activity
I6K18_RS11990	COG1695	Transcriptional regulator
I6K18_RS11995	COG2375	cellular response to nickel ion
I6K18_RS12010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K18_RS12015	COG0358	DNA primase activity
I6K18_RS12020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K18_RS12035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS12040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS12055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K18_RS12070	COG4991	sh3 domain protein
I6K18_RS12075	COG3025	triphosphatase activity
I6K18_RS12100	COG2268	Band 7 protein
I6K18_RS12105	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K18_RS12135	COG3384	dioxygenase
I6K18_RS12145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K18_RS12155	COG0754	glutathionylspermidine amidase activity
I6K18_RS12165	COG1538	Outer membrane efflux protein
I6K18_RS12170	COG0494	nUDIX hydrolase
I6K18_RS12175	COG3151	Protein conserved in bacteria
I6K18_RS12180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K18_RS12185	COG3150	esterase
I6K18_RS12190	COG0187	DNA topoisomerase II activity
I6K18_RS12195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K18_RS12200	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K18_RS12210	COG0642	Histidine kinase
I6K18_RS12215	COG0745	RESPONSE REGULATOR receiver
I6K18_RS12220	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K18_RS12225	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K18_RS12235	COG2944	sequence-specific DNA binding
I6K18_RS12240	COG4166	transmembrane transport
I6K18_RS12245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K18_RS12250	COG0204	Acyl-transferase
I6K18_RS12255	COG2132	Multicopper oxidase
I6K18_RS12260	COG1032	radical SAM domain protein
I6K18_RS12265	COG4238	major outer membrane lipoprotein
I6K18_RS12275	COG0656	L-ascorbic acid biosynthetic process
I6K18_RS12280	COG1979	alcohol dehydrogenase
I6K18_RS12285	COG2207	Transcriptional regulator
I6K18_RS12290	COG0586	Pfam SNARE associated Golgi protein
I6K18_RS12295	COG0626	cystathionine gamma-synthase activity
I6K18_RS12300	COG0811	peptide transport
I6K18_RS12305	COG0848	biopolymer transport protein
I6K18_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS12320	COG0667	Aldo Keto reductase
I6K18_RS12335	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K18_RS12340	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS12345	COG5557	Pfam Polysulphide reductase, NrfD
I6K18_RS12350	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K18_RS12355	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K18_RS12360	COG1773	rubredoxin
I6K18_RS12370	COG0298	carbon dioxide binding
I6K18_RS12375	COG0625	glutathione transferase activity
I6K18_RS12380	COG0754	glutathionylspermidine amidase activity
I6K18_RS12395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K18_RS12405	COG0318	PFAM AMP-dependent synthetase and ligase
I6K18_RS12415	COG0456	acetyltransferase
I6K18_RS12425	COG0277	FAD linked oxidase domain protein
I6K18_RS12430	COG0277	FAD linked oxidase domain protein
I6K18_RS12435	COG0247	lactate metabolic process
I6K18_RS12440	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K18_RS12445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K18_RS12450	COG1620	l-lactate permease
I6K18_RS12455	COG3064	Membrane
I6K18_RS12460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K18_RS12480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K18_RS12485	COG1459	type II secretion system
I6K18_RS12490	COG2165	general secretion pathway protein
I6K18_RS12520	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K18_RS12555	COG0463	Glycosyl transferase, family 2
I6K18_RS12650	COG2003	Belongs to the UPF0758 family
I6K18_RS12675	COG2020	methyltransferase activity
I6K18_RS12680	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS12690	COG4983	Phage plasmid primase, P4 family domain protein
I6K18_RS12730	COG4372	Transposase
I6K18_RS12740	COG3436	PFAM IS66 Orf2 family protein
I6K18_RS12755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K18_RS12760	COG1940	carbohydrate kinase activity
I6K18_RS12765	COG2814	Major facilitator Superfamily
I6K18_RS12775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K18_RS12780	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6K18_RS12785	COG0657	acetylesterase activity
I6K18_RS12785	COG2755	lipolytic protein G-D-S-L family
I6K18_RS12865	COG0582	viral genome integration into host DNA
I6K18_RS12875	COG1811	Na channel or pump
I6K18_RS12880	COG1982	Orn Lys Arg decarboxylase major
I6K18_RS12885	COG2211	Major facilitator Superfamily
I6K18_RS12900	COG1194	a g-specific adenine glycosylase
I6K18_RS12910	COG3171	Protein conserved in bacteria
I6K18_RS12920	COG0252	asparaginase activity
I6K18_RS12930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K18_RS12945	COG0762	integral membrane protein
I6K18_RS12950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K18_RS12955	COG2805	Type II/IV secretion system protein
I6K18_RS12970	COG0189	ligase activity
I6K18_RS12975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K18_RS12980	COG2356	endonuclease I
I6K18_RS12990	COG2814	Major facilitator Superfamily
I6K18_RS13010	COG1166	arginine decarboxylase activity
I6K18_RS13020	COG0501	Belongs to the peptidase M48B family
I6K18_RS13025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K18_RS13030	COG0330	HflC and HflK could
I6K18_RS13035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS13040	COG2213	PTS system mannitol-specific
I6K18_RS13045	COG1063	alcohol dehydrogenase
I6K18_RS13050	COG1494	fructose-1,6-bisphosphatase
I6K18_RS13060	COG1072	(Pantothenic acid kinase))
I6K18_RS13065	COG1122	ATPase activity
I6K18_RS13070	COG1122	ATPase activity
I6K18_RS13100	COG0191	fructose-bisphosphate aldolase activity
I6K18_RS13105	COG0668	transmembrane transport
I6K18_RS13115	COG1279	arginine transmembrane transporter activity
I6K18_RS13120	COG2968	Membrane
I6K18_RS13125	COG0583	DNA-binding transcription factor activity
I6K18_RS13130	COG0427	acetyl-CoA hydrolase
I6K18_RS13135	COG1024	Enoyl-CoA hydratase
I6K18_RS13140	COG1703	isobutyryl-CoA mutase activity
I6K18_RS13145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K18_RS13145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K18_RS13155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K18_RS13165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6K18_RS13180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K18_RS13190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K18_RS13210	COG0006	proline dipeptidase activity
I6K18_RS13215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K18_RS13220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K18_RS13245	COG2723	6-phospho-beta-galactosidase activity
I6K18_RS13255	COG1272	protein, Hemolysin III
I6K18_RS13265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K18_RS13275	COG0716	FMN binding
I6K18_RS13280	COG4974	Belongs to the 'phage' integrase family
I6K18_RS13285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K18_RS13290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K18_RS13300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K18_RS13320	COG2233	PERMEase
I6K18_RS13325	COG0493	'glutamate synthase
I6K18_RS13325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS13330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS13335	COG2252	PERMEase
I6K18_RS13340	COG0402	S-adenosylhomocysteine deaminase activity
I6K18_RS13345	COG2233	PERMEase
I6K18_RS13350	COG2080	2 iron, 2 sulfur cluster binding
I6K18_RS13350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K18_RS13355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K18_RS13360	COG0402	S-adenosylhomocysteine deaminase activity
I6K18_RS13365	COG0493	'glutamate synthase
I6K18_RS13365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS13370	COG2068	MobA-Related Protein
I6K18_RS13375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K18_RS13380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K18_RS13380	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K18_RS13385	COG0549	Belongs to the carbamate kinase family
I6K18_RS13395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K18_RS13400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K18_RS13405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K18_RS13410	COG3829	transcription factor binding
I6K18_RS13415	COG2080	2 iron, 2 sulfur cluster binding
I6K18_RS13420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K18_RS13425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K18_RS13430	COG4942	peptidase
I6K18_RS13440	COG3387	PFAM Glycoside hydrolase 15-related
I6K18_RS13450	COG2207	Transcriptional regulator
I6K18_RS13550	COG2197	response regulator
I6K18_RS13555	COG0741	lytic transglycosylase activity
I6K18_RS13565	COG0457	Tetratricopeptide repeat
I6K18_RS13565	COG3710	Transcriptional regulator
I6K18_RS13570	COG0457	Tetratricopeptide repeat
I6K18_RS13595	COG3710	Transcriptional regulator
I6K18_RS13600	COG2771	luxR family
I6K18_RS13605	COG0814	amino acid
I6K18_RS13610	COG0183	Belongs to the thiolase family
I6K18_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS13625	COG2814	Major facilitator Superfamily
I6K18_RS13630	COG1794	racemase activity, acting on amino acids and derivatives
I6K18_RS13635	COG0583	DNA-binding transcription factor activity
I6K18_RS13645	COG1609	Transcriptional regulator
I6K18_RS13660	COG0667	Aldo Keto reductase
I6K18_RS13670	COG0861	Integral membrane protein TerC family
I6K18_RS13685	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6K18_RS13700	COG2165	general secretion pathway protein
I6K18_RS13705	COG4795	General secretion pathway protein
I6K18_RS13715	COG4967	type IV pilus modification protein PilV
I6K18_RS13720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K18_RS13730	COG1074	ATP-dependent DNA helicase activity
I6K18_RS13735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K18_RS13740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K18_RS13740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K18_RS13745	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K18_RS13765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K18_RS13770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K18_RS13775	COG2166	iron-sulfur cluster assembly
I6K18_RS13780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K18_RS13790	COG0583	DNA-binding transcription factor activity
I6K18_RS13795	COG2363	Small membrane protein
I6K18_RS13805	COG1349	DNA-binding transcription factor activity
I6K18_RS13815	COG1070	Carbohydrate kinase
I6K18_RS13825	COG0738	Major facilitator superfamily
I6K18_RS13830	COG0235	Class ii aldolase
I6K18_RS13835	COG1454	alcohol dehydrogenase
I6K18_RS13845	COG1760	l-serine dehydratase
I6K18_RS13865	COG1611	Belongs to the LOG family
I6K18_RS13880	COG3098	single-species biofilm formation
I6K18_RS13885	COG0564	pseudouridine synthase activity
I6K18_RS13890	COG0716	FMN binding
I6K18_RS13895	COG2271	Major facilitator Superfamily
I6K18_RS13900	COG4948	Mandelate Racemase Muconate Lactonizing
I6K18_RS13905	COG4948	Mandelate Racemase Muconate Lactonizing
I6K18_RS13910	COG3850	Histidine kinase
I6K18_RS13910	COG4999	Histidine kinase
I6K18_RS13910	COG3437	response regulator, receiver
I6K18_RS13910	COG2205	protein histidine kinase activity
I6K18_RS13920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K18_RS13925	COG3956	TIGRFAM MazG family protein
I6K18_RS13940	COG3385	transposase activity
I6K18_RS13945	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K18_RS13955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K18_RS13965	COG0602	queuosine metabolic process
I6K18_RS13970	COG1070	Carbohydrate kinase
I6K18_RS13975	COG2223	nitrite transmembrane transporter activity
I6K18_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS13985	COG0277	FAD linked oxidase domain protein
I6K18_RS13990	COG0477	Major facilitator Superfamily
I6K18_RS13995	COG2086	electron transfer activity
I6K18_RS14000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K18_RS14005	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6K18_RS14010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K18_RS14015	COG0644	oxidoreductase
I6K18_RS14020	COG0720	synthase
I6K18_RS14045	COG1203	CRISPR-associated helicase, Cas3
I6K18_RS14060	COG1857	crispr-associated protein
I6K18_RS14080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K18_RS14085	COG2234	aminopeptidase activity
I6K18_RS14140	COG1388	LysM domain
I6K18_RS14140	COG4942	peptidase
I6K18_RS14145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K18_RS14155	COG0163	prenyltransferase activity
I6K18_RS14160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K18_RS14170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K18_RS14200	COG3604	Transcriptional regulator
I6K18_RS14205	COG0309	Hydrogenase expression formation protein (HypE)
I6K18_RS14210	COG0409	Hydrogenase expression formation protein
I6K18_RS14215	COG0298	carbon dioxide binding
I6K18_RS14220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K18_RS14225	COG0375	protein maturation
I6K18_RS14230	COG3039	Transposase
I6K18_RS14240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS14245	COG0651	ATP synthesis coupled electron transport
I6K18_RS14250	COG0650	Formate hydrogenlyase subunit 4
I6K18_RS14255	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K18_RS14255	COG3261	NADH dehydrogenase
I6K18_RS14260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K18_RS14265	COG3260	NADH ubiquinone oxidoreductase 20
I6K18_RS14275	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K18_RS14280	COG2723	6-phospho-beta-galactosidase activity
I6K18_RS14285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS14285	COG1263	PTS System
I6K18_RS14290	COG1609	Transcriptional regulator
I6K18_RS14295	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS14300	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K18_RS14325	COG1349	DNA-binding transcription factor activity
I6K18_RS14330	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS14345	COG3732	PTS system glucitol sorbitol-specific
I6K18_RS14350	COG3730	PTS system glucitol sorbitol-specific
I6K18_RS14355	COG2951	lytic endotransglycosylase activity
I6K18_RS14360	COG1546	Belongs to the CinA family
I6K18_RS14380	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K18_RS14410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K18_RS14415	COG1238	metal cluster binding
I6K18_RS14430	COG2814	Major facilitator Superfamily
I6K18_RS14435	COG1566	PFAM secretion protein HlyD family protein
I6K18_RS14440	COG1846	Transcriptional regulator
I6K18_RS14450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K18_RS14455	COG2814	Major facilitator Superfamily
I6K18_RS14460	COG2113	Glycine betaine
I6K18_RS14465	COG4176	ABC-type proline glycine betaine transport system permease component
I6K18_RS14470	COG4175	Glycine betaine
I6K18_RS14475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K18_RS14480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K18_RS14490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K18_RS14495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K18_RS14500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K18_RS14505	COG4575	ribosome binding
I6K18_RS14520	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K18_RS14525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K18_RS14530	COG0640	Transcriptional regulator
I6K18_RS14535	COG0401	homolog of Blt101
I6K18_RS14540	COG1652	LysM domain
I6K18_RS14545	COG1802	Transcriptional regulator
I6K18_RS14550	COG1113	amino acid transport
I6K18_RS14555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K18_RS14560	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS14565	COG0579	oxidoreductase
I6K18_RS14605	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS14635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K18_RS14650	COG2190	(PTS) system
I6K18_RS14650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS14650	COG1263	PTS System
I6K18_RS14660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K18_RS14665	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K18_RS14680	COG3732	PTS system glucitol sorbitol-specific
I6K18_RS14750	COG0582	viral genome integration into host DNA
I6K18_RS14765	COG2867	negative regulation of translational initiation
I6K18_RS14775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K18_RS14780	COG0497	DNA recombination
I6K18_RS14795	COG4536	flavin adenine dinucleotide binding
I6K18_RS14800	COG4137	Cytochrome C assembly protein
I6K18_RS14805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K18_RS14830	COG2885	chlorophyll binding
I6K18_RS14835	COG2199	diguanylate cyclase activity
I6K18_RS14850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K18_RS14855	COG0287	Prephenate dehydrogenase
I6K18_RS14855	COG1605	Chorismate mutase
I6K18_RS14860	COG0077	Prephenate dehydratase
I6K18_RS14860	COG1605	Chorismate mutase
I6K18_RS14870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K18_RS14875	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K18_RS14880	COG0564	pseudouridine synthase activity
I6K18_RS14890	COG0542	response to heat
I6K18_RS14915	COG0477	Major facilitator Superfamily
I6K18_RS14920	COG5544	Lipoprotein
I6K18_RS14925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K18_RS14930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K18_RS14930	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K18_RS14930	COG1042	CoA-binding domain protein
I6K18_RS14935	COG3148	PFAM DTW domain containing protein
I6K18_RS14940	COG3118	belongs to the thioredoxin family
I6K18_RS14945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K18_RS14965	COG0583	DNA-binding transcription factor activity
I6K18_RS14975	COG0513	Belongs to the DEAD box helicase family
I6K18_RS14985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K18_RS14995	COG1595	DNA-templated transcription, initiation
I6K18_RS15000	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K18_RS15005	COG3026	antisigma factor binding
I6K18_RS15010	COG3086	response to oxidative stress
I6K18_RS15020	COG0681	Belongs to the peptidase S26 family
I6K18_RS15040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K18_RS15055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS15060	COG1737	Transcriptional regulator
I6K18_RS15065	COG0560	Phosphoserine phosphatase
I6K18_RS15070	COG0590	tRNA wobble adenosine to inosine editing
I6K18_RS15080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K18_RS15080	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K18_RS15085	COG2205	protein histidine kinase activity
I6K18_RS15090	COG3170	Tfp pilus assembly protein FimV
I6K18_RS15095	COG2204	response regulator
I6K18_RS15100	COG0347	Belongs to the P(II) protein family
I6K18_RS15105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K18_RS15105	COG1017	nitric oxide dioxygenase activity
I6K18_RS15115	COG1940	carbohydrate kinase activity
I6K18_RS15120	COG0457	Tetratricopeptide repeat
I6K18_RS15125	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS15130	COG1129	ABC transporter
I6K18_RS15135	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS15140	COG1063	alcohol dehydrogenase
I6K18_RS15145	COG2017	converts alpha-aldose to the beta-anomer
I6K18_RS15150	COG2259	Doxx family
I6K18_RS15175	COG4638	Rieske (2fe-2S)
I6K18_RS15180	COG0583	DNA-binding transcription factor activity
I6K18_RS15185	COG2814	Major facilitator Superfamily
I6K18_RS15190	COG3711	transcriptional antiterminator
I6K18_RS15195	COG1073	alpha beta
I6K18_RS15200	COG0483	inositol monophosphate 1-phosphatase activity
I6K18_RS15220	COG0822	iron-sulfur transferase activity
I6K18_RS15240	COG0633	Ferredoxin
I6K18_RS15245	COG2975	iron-sulfur cluster assembly
I6K18_RS15260	COG2897	thiosulfate sulfurtransferase activity
I6K18_RS15265	COG2373	Large extracellular alpha-helical protein
I6K18_RS15270	COG4953	penicillin-binding protein 1C
I6K18_RS15300	COG2976	Protein conserved in bacteria
I6K18_RS15315	COG1645	bacterial-type flagellum-dependent swarming motility
I6K18_RS15340	COG0517	IMP dehydrogenase activity
I6K18_RS15340	COG0516	GMP reductase activity
I6K18_RS15380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K18_RS15465	COG5484	DNA packaging
I6K18_RS15465	COG3728	DNA packaging
I6K18_RS15585	COG3561	AntA/AntB antirepressor
I6K18_RS15610	COG3179	chitinase
I6K18_RS15630	COG3133	Outer membrane lipoprotein
I6K18_RS15645	COG2200	EAL domain
I6K18_RS15650	COG0248	Ppx GppA phosphatase
I6K18_RS15655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6K18_RS15660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K18_RS15675	COG2233	PERMEase
I6K18_RS15685	COG1393	Belongs to the ArsC family
I6K18_RS15690	COG4783	chaperone-mediated protein folding
I6K18_RS15695	COG0628	permease
I6K18_RS15700	COG2116	formate transmembrane transporter activity
I6K18_RS15705	COG3604	Transcriptional regulator
I6K18_RS15715	COG3260	NADH ubiquinone oxidoreductase 20
I6K18_RS15720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K18_RS15725	COG3261	NADH dehydrogenase
I6K18_RS15725	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K18_RS15730	COG0651	ATP synthesis coupled electron transport
I6K18_RS15735	COG4237	Hydrogenase 4 membrane
I6K18_RS15740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K18_RS15745	COG0650	Formate hydrogenlyase subunit 4
I6K18_RS15750	COG0651	ATP synthesis coupled electron transport
I6K18_RS15755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS15760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K18_RS15765	COG2716	regulation of RNA biosynthetic process
I6K18_RS15775	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K18_RS15785	COG2321	neutral zinc metallopeptidase
I6K18_RS15795	COG0400	carboxylic ester hydrolase activity
I6K18_RS15810	COG1393	Belongs to the ArsC family
I6K18_RS15820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K18_RS15825	COG3850	Histidine kinase
I6K18_RS15830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS15830	COG0493	'glutamate synthase
I6K18_RS15840	COG5342	invasion associated locus B
I6K18_RS15845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K18_RS15850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K18_RS15855	COG0281	malic enzyme
I6K18_RS15855	COG0280	phosphate acetyltransferase
I6K18_RS15860	COG4810	utilization protein
I6K18_RS15865	COG4917	ethanolamine utilization protein
I6K18_RS15870	COG4766	ethanolamine catabolic process
I6K18_RS15875	COG4812	Cobalamin adenosyltransferase
I6K18_RS15880	COG0280	phosphate acetyltransferase
I6K18_RS15885	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K18_RS15890	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K18_RS15895	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS15900	COG4820	ethanolamine utilization protein (EutJ)
I6K18_RS15905	COG1454	alcohol dehydrogenase
I6K18_RS15910	COG3192	ethanolamine utilization protein
I6K18_RS15915	COG4819	ethanolamine utilization protein
I6K18_RS15920	COG4303	Ethanolamine ammonia lyase large subunit
I6K18_RS15930	COG4816	utilization protein
I6K18_RS15935	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K18_RS15940	COG2207	Transcriptional regulator
I6K18_RS15950	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K18_RS15980	COG2837	iron assimilation
I6K18_RS15985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K18_RS15990	COG1263	PTS System
I6K18_RS15990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS16010	COG4150	thiosulfate binding
I6K18_RS16015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K18_RS16020	COG4208	sulfate ABC transporter
I6K18_RS16025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K18_RS16030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K18_RS16045	COG2190	(PTS) system
I6K18_RS16050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K18_RS16055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS16060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K18_RS16080	COG3530	Putative quorum-sensing-regulated virulence factor
I6K18_RS16085	COG0385	Bile acid
I6K18_RS16090	COG0583	DNA-binding transcription factor activity
I6K18_RS16140	COG3415	Transposase
I6K18_RS16155	COG2199	diguanylate cyclase activity
I6K18_RS16155	COG2200	EAL domain
I6K18_RS16160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K18_RS16185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS16190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS16195	COG0006	proline dipeptidase activity
I6K18_RS16200	COG1363	Peptidase, m42
I6K18_RS16210	COG2207	Transcriptional regulator
I6K18_RS16215	COG3279	Response regulator of the LytR AlgR family
I6K18_RS16220	COG3275	phosphorelay sensor kinase activity
I6K18_RS16225	COG0436	Aminotransferase
I6K18_RS16235	COG1560	Kdo2-lipid A biosynthetic process
I6K18_RS16260	COG0028	Belongs to the TPP enzyme family
I6K18_RS16265	COG0679	Auxin Efflux Carrier
I6K18_RS16270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K18_RS16275	COG2205	protein histidine kinase activity
I6K18_RS16275	COG0784	Response regulator, receiver
I6K18_RS16275	COG2198	Histidine kinase
I6K18_RS16275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS16280	COG2197	response regulator
I6K18_RS16285	COG1566	PFAM secretion protein HlyD family protein
I6K18_RS16290	COG0477	Major facilitator Superfamily
I6K18_RS16335	COG2116	formate transmembrane transporter activity
I6K18_RS16340	COG2853	Lipoprotein
I6K18_RS16350	COG2067	long-chain fatty acid transport protein
I6K18_RS16355	COG3691	Protein conserved in bacteria
I6K18_RS16370	COG2062	phosphohistidine phosphatase, SixA
I6K18_RS16375	COG3539	Fimbrial protein
I6K18_RS16380	COG3188	usher protein
I6K18_RS16385	COG3121	Chaperone
I6K18_RS16390	COG3539	Fimbrial protein
I6K18_RS16395	COG3539	Fimbrial protein
I6K18_RS16400	COG3539	Fimbrial protein
I6K18_RS16415	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K18_RS16430	COG0730	response to heat
I6K18_RS16435	COG3101	peptidyl-lysine hydroxylation
I6K18_RS16450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K18_RS16455	COG2814	Major facilitator Superfamily
I6K18_RS16470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K18_RS16480	COG0586	Pfam SNARE associated Golgi protein
I6K18_RS16490	COG0285	dihydrofolate synthase activity
I6K18_RS16495	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K18_RS16500	COG1286	toxin biosynthetic process
I6K18_RS16505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K18_RS16510	COG0163	prenyltransferase activity
I6K18_RS16515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS16520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS16525	COG4215	(ABC) transporter
I6K18_RS16530	COG4160	amino acid transport
I6K18_RS16535	COG4598	ABC transporter
I6K18_RS16540	COG5464	transposase or invertase
I6K18_RS16545	COG1090	epimerase
I6K18_RS16550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K18_RS16555	COG0625	glutathione transferase activity
I6K18_RS16560	COG0625	glutathione transferase activity
I6K18_RS16565	COG0622	Phosphoesterase
I6K18_RS16570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K18_RS16575	COG1288	antiporter activity
I6K18_RS16580	COG0280	phosphate acetyltransferase
I6K18_RS16580	COG0857	belongs to the CobB CobQ family
I6K18_RS16585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K18_RS16600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K18_RS16605	COG0490	domain, Protein
I6K18_RS16605	COG0471	metal ion transport
I6K18_RS16615	COG0436	Aminotransferase
I6K18_RS16620	COG0583	DNA-binding transcription factor activity
I6K18_RS16640	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K18_RS16645	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K18_RS16650	COG1034	ATP synthesis coupled electron transport
I6K18_RS16665	COG0839	Belongs to the complex I subunit 6 family
I6K18_RS16675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K18_RS16680	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K18_RS16695	COG2234	aminopeptidase activity
I6K18_RS16700	COG5160	protein modification by small protein removal
I6K18_RS16710	COG2153	protein acetylation
I6K18_RS16715	COG4575	ribosome binding
I6K18_RS16720	COG1169	isochorismate synthase
I6K18_RS16735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K18_RS16745	COG0318	PFAM AMP-dependent synthetase and ligase
I6K18_RS16815	COG0675	Transposase, IS605 OrfB family
I6K18_RS16820	COG2271	Major facilitator Superfamily
I6K18_RS16835	COG5464	transposase or invertase
I6K18_RS16840	COG0247	lactate metabolic process
I6K18_RS16850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K18_RS16855	COG2271	Major facilitator Superfamily
I6K18_RS16860	COG0584	glycerophosphoryl diester phosphodiesterase
I6K18_RS16870	COG0583	DNA-binding transcription factor activity
I6K18_RS16875	COG2814	Major facilitator Superfamily
I6K18_RS16880	COG3642	lipopolysaccharide core region biosynthetic process
I6K18_RS16885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K18_RS16890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K18_RS16895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K18_RS16900	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS16910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K18_RS16920	COG3234	Protein of unknown function (DUF1175)
I6K18_RS16925	COG2373	Large extracellular alpha-helical protein
I6K18_RS16930	COG5445	Predicted secreted protein (DUF2300)
I6K18_RS16935	COG4676	Protein conserved in bacteria
I6K18_RS16940	COG0183	Belongs to the thiolase family
I6K18_RS16945	COG2031	fatty acid transporter
I6K18_RS16950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K18_RS16955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K18_RS16960	COG2204	response regulator
I6K18_RS16965	COG3852	Histidine kinase
I6K18_RS16970	COG0784	Response regulator, receiver
I6K18_RS16970	COG2205	protein histidine kinase activity
I6K18_RS16975	COG2197	response regulator
I6K18_RS16980	COG2198	Histidine kinase
I6K18_RS16980	COG0642	Histidine kinase
I6K18_RS16985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K18_RS16990	COG1477	protein flavinylation
I6K18_RS16995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K18_RS16995	COG2169	Transcriptional regulator
I6K18_RS17000	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K18_RS17005	COG4615	Cyclic peptide transporter
I6K18_RS17020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS17020	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K18_RS17025	COG3062	negative regulation of establishment of protein localization
I6K18_RS17035	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS17040	COG0348	domain, Protein
I6K18_RS17045	COG3043	anaerobic respiration
I6K18_RS17050	COG3005	denitrification pathway
I6K18_RS17060	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K18_RS17065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K18_RS17070	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K18_RS17080	COG1138	Cytochrome C-type biogenesis protein
I6K18_RS17085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K18_RS17090	COG4235	cytochrome complex assembly
I6K18_RS17090	COG3088	subunit of a heme lyase
I6K18_RS17095	COG2197	response regulator
I6K18_RS17100	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS17110	COG3083	sulfuric ester hydrolase activity
I6K18_RS17130	COG1061	Type III restriction enzyme res subunit
I6K18_RS17135	COG1187	pseudouridine synthase activity
I6K18_RS17140	COG2814	Major facilitator Superfamily
I6K18_RS17150	COG4172	Belongs to the ABC transporter superfamily
I6K18_RS17155	COG4239	(ABC) transporter, permease
I6K18_RS17160	COG4174	ABC transporter (Permease)
I6K18_RS17165	COG4166	transmembrane transport
I6K18_RS17170	COG2200	EAL domain
I6K18_RS17175	COG0791	NLP P60 protein
I6K18_RS17180	COG0671	phosphoesterase, PA-phosphatase related
I6K18_RS17185	COG0523	cobalamin synthesis protein
I6K18_RS17190	COG0246	Mannitol dehydrogenase
I6K18_RS17205	COG2814	Major facilitator Superfamily
I6K18_RS17210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS17210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS17215	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K18_RS17220	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K18_RS17220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS17220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS17225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS17230	COG2313	pseudouridylate synthase activity
I6K18_RS17235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K18_RS17240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K18_RS17250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K18_RS17255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS17255	COG1522	sequence-specific DNA binding
I6K18_RS17265	COG2855	membrane
I6K18_RS17270	COG0583	DNA-binding transcription factor activity
I6K18_RS17275	COG0833	amino acid
I6K18_RS17280	COG4771	TonB-dependent receptor
I6K18_RS17285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6K18_RS17295	COG2311	Membrane
I6K18_RS17300	COG1609	Transcriptional regulator
I6K18_RS17305	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS17310	COG1129	ABC transporter
I6K18_RS17315	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS17320	COG0167	dihydroorotate dehydrogenase activity
I6K18_RS17320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K18_RS17325	COG0493	'glutamate synthase
I6K18_RS17335	COG2949	membrane
I6K18_RS17345	COG1346	cytolysis
I6K18_RS17355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K18_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS17375	COG0586	Pfam SNARE associated Golgi protein
I6K18_RS17385	COG1686	Belongs to the peptidase S11 family
I6K18_RS17390	COG0277	FAD linked oxidase domain protein
I6K18_RS17395	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K18_RS17400	COG1732	Glycine betaine
I6K18_RS17405	COG1174	glycine betaine transport
I6K18_RS17410	COG1125	glycine betaine transport
I6K18_RS17415	COG1174	glycine betaine transport
I6K18_RS17425	COG0789	Transcriptional regulator
I6K18_RS17430	COG3275	phosphorelay sensor kinase activity
I6K18_RS17435	COG3279	Response regulator of the LytR AlgR family
I6K18_RS17440	COG4807	Protein conserved in bacteria
I6K18_RS17445	COG4808	Protein conserved in bacteria
I6K18_RS17450	COG4715	Zinc finger, swim domain protein
I6K18_RS17455	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K18_RS17460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K18_RS17465	COG0714	Associated with various cellular activities
I6K18_RS17475	COG3831	ATPase activity
I6K18_RS17480	COG3831	ATPase activity
I6K18_RS17485	COG3831	ATPase activity
I6K18_RS17495	COG0489	protein tyrosine kinase activity
I6K18_RS17505	COG3539	Fimbrial protein
I6K18_RS17510	COG3121	Chaperone
I6K18_RS17515	COG3188	usher protein
I6K18_RS17520	COG3539	Fimbrial protein
I6K18_RS17525	COG5455	response to cobalt ion
I6K18_RS17545	COG0351	phosphomethylpyrimidine kinase
I6K18_RS17550	COG3757	hydrolase, family 25
I6K18_RS17555	COG2188	Transcriptional regulator
I6K18_RS17560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS17565	COG1397	ADP-ribosylglycohydrolase
I6K18_RS17570	COG2211	Major facilitator Superfamily
I6K18_RS17575	COG1830	Aldolase
I6K18_RS17590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS17595	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K18_RS17600	COG3775	system Galactitol-specific IIC component
I6K18_RS17605	COG1063	alcohol dehydrogenase
I6K18_RS17625	COG0826	peptidase U32
I6K18_RS17635	COG0745	RESPONSE REGULATOR receiver
I6K18_RS17640	COG2205	protein histidine kinase activity
I6K18_RS17685	COG4245	von Willebrand factor, type A
I6K18_RS17690	COG0631	protein serine/threonine phosphatase activity
I6K18_RS17695	COG3779	Protein conserved in bacteria
I6K18_RS17700	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6K18_RS17705	COG0443	Heat shock 70 kDa protein
I6K18_RS17710	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K18_RS17715	COG3447	MASE1 domain protein
I6K18_RS17715	COG5001	Diguanylate cyclase
I6K18_RS17715	COG5002	protein histidine kinase activity
I6K18_RS17720	COG0572	uridine kinase
I6K18_RS17730	COG2982	Protein involved in outer membrane biogenesis
I6K18_RS17745	COG1253	flavin adenine dinucleotide binding
I6K18_RS17755	COG1596	polysaccharide export
I6K18_RS17760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K18_RS17765	COG0489	protein tyrosine kinase activity
I6K18_RS17765	COG3206	protein involved in exopolysaccharide biosynthesis
I6K18_RS17770	COG0463	Glycosyl transferase, family 2
I6K18_RS17775	COG1045	serine acetyltransferase
I6K18_RS17780	COG0438	transferase activity, transferring glycosyl groups
I6K18_RS17790	COG1216	Glycosyl transferase, family 2
I6K18_RS17795	COG0110	maltose O-acetyltransferase activity
I6K18_RS17800	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6K18_RS17805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K18_RS17810	COG1051	belongs to the nudix hydrolase family
I6K18_RS17815	COG0297	glycogen (starch) synthase activity
I6K18_RS17820	COG0662	Cupin 2, conserved barrel domain protein
I6K18_RS17820	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6K18_RS17825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K18_RS17830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K18_RS17835	COG2244	polysaccharide biosynthetic process
I6K18_RS17840	COG2327	Polysaccharide pyruvyl transferase
I6K18_RS17845	COG0438	transferase activity, transferring glycosyl groups
I6K18_RS17855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K18_RS17890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K18_RS17895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6K18_RS17905	COG0140	phosphoribosyl-ATP diphosphatase activity
I6K18_RS17905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6K18_RS17920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K18_RS17925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K18_RS17925	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K18_RS17950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K18_RS17955	COG0583	DNA-binding transcription factor activity
I6K18_RS17965	COG0531	amino acid
I6K18_RS17970	COG2925	Exonuclease
I6K18_RS17975	COG1686	Belongs to the peptidase S11 family
I6K18_RS17985	COG1289	transmembrane transporter activity
I6K18_RS18010	COG4656	Part of a membrane complex involved in electron transport
I6K18_RS18030	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K18_RS18045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K18_RS18105	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6K18_RS18120	COG1376	ErfK ybiS ycfS ynhG family protein
I6K18_RS18130	COG0583	DNA-binding transcription factor activity
I6K18_RS18135	COG0583	DNA-binding transcription factor activity
I6K18_RS18145	COG0534	Mate efflux family protein
I6K18_RS18155	COG0217	transcriptional regulatory protein
I6K18_RS18160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K18_RS18165	COG0477	Major facilitator Superfamily
I6K18_RS18175	COG4932	domain protein
I6K18_RS18175	COG1388	LysM domain
I6K18_RS18175	COG2373	Large extracellular alpha-helical protein
I6K18_RS18235	COG4227	nucleotidyltransferase activity
I6K18_RS18275	COG3504	Conjugal transfer protein
I6K18_RS18355	COG4771	TonB-dependent receptor
I6K18_RS18360	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K18_RS18380	COG2226	methyltransferase
I6K18_RS18380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K18_RS18380	COG3433	isochorismatase activity
I6K18_RS18395	COG1132	(ABC) transporter
I6K18_RS18400	COG2814	Major facilitator Superfamily
I6K18_RS18405	COG1169	isochorismate synthase
I6K18_RS18410	COG0582	viral genome integration into host DNA
I6K18_RS18430	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K18_RS18445	COG2351	hydroxyisourate hydrolase activity
I6K18_RS18450	COG0745	RESPONSE REGULATOR receiver
I6K18_RS18455	COG2205	protein histidine kinase activity
I6K18_RS18470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K18_RS18480	COG1418	mRNA catabolic process
I6K18_RS18485	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K18_RS18490	COG3727	T/G mismatch-specific endonuclease activity
I6K18_RS18495	COG0697	spore germination
I6K18_RS18500	COG2354	Protein conserved in bacteria
I6K18_RS18505	COG5475	Uncharacterized small protein (DUF2158)
I6K18_RS18535	COG2197	response regulator
I6K18_RS18540	COG1684	flagellar biosynthetic protein fliR
I6K18_RS18545	COG1987	bacterial-type flagellum assembly
I6K18_RS18550	COG1338	Plays a role in the flagellum-specific transport system
I6K18_RS18555	COG3190	flagellar
I6K18_RS18560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K18_RS18565	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K18_RS18570	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K18_RS18575	COG3144	bacterial-type flagellum assembly
I6K18_RS18580	COG2882	bacterial-type flagellum organization
I6K18_RS18585	COG1157	protein secretion by the type III secretion system
I6K18_RS18590	COG1317	bacterial-type flagellum organization
I6K18_RS18595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K18_RS18600	COG1766	The M ring may be actively involved in energy transduction
I6K18_RS18620	COG2135	peptidase activity
I6K18_RS18625	COG0425	Belongs to the sulfur carrier protein TusA family
I6K18_RS18630	COG2391	methyltransferase activity
I6K18_RS18640	COG0366	Alpha amylase catalytic
I6K18_RS18650	COG1516	flagellar protein fliS
I6K18_RS18655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K18_RS18665	COG1191	sigma factor activity
I6K18_RS18675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS18685	COG0765	amino acid transport
I6K18_RS18690	COG1126	abc transporter atp-binding protein
I6K18_RS18695	COG2197	response regulator
I6K18_RS18710	COG2197	response regulator
I6K18_RS18805	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS18885	COG4695	Portal protein
I6K18_RS18930	COG3039	Transposase
I6K18_RS18970	COG4974	Belongs to the 'phage' integrase family
I6K18_RS18975	COG3318	Belongs to the UPF0149 family
I6K18_RS18975	COG3012	SEC-C Motif Domain Protein
I6K18_RS18980	COG0814	amino acid
I6K18_RS18990	COG1528	Iron-storage protein
I6K18_RS19010	COG1528	Iron-storage protein
I6K18_RS19015	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS19025	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K18_RS19030	COG1877	trehalose-phosphatase activity
I6K18_RS19040	COG0589	response to stress
I6K18_RS19055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K18_RS19060	COG1360	Flagellar Motor Protein
I6K18_RS19065	COG0643	Histidine kinase
I6K18_RS19065	COG2198	Histidine kinase
I6K18_RS19070	COG0835	chemotaxis
I6K18_RS19075	COG0840	transmembrane signaling receptor activity
I6K18_RS19080	COG0840	transmembrane signaling receptor activity
I6K18_RS19085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6K18_RS19095	COG0745	RESPONSE REGULATOR receiver
I6K18_RS19100	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K18_RS19105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K18_RS19110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K18_RS19125	COG3102	Protein conserved in bacteria
I6K18_RS19135	COG3005	denitrification pathway
I6K18_RS19140	COG0243	molybdopterin cofactor binding
I6K18_RS19155	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K18_RS19160	COG1801	Protein of unknown function DUF72
I6K18_RS19165	COG1335	isochorismatase
I6K18_RS19175	COG0494	nUDIX hydrolase
I6K18_RS19180	COG0217	transcriptional regulatory protein
I6K18_RS19210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K18_RS19220	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K18_RS19225	COG0739	heme binding
I6K18_RS19230	COG1560	Kdo2-lipid A biosynthetic process
I6K18_RS19235	COG0469	pyruvate kinase activity
I6K18_RS19240	COG1737	Transcriptional regulator
I6K18_RS19245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K18_RS19250	COG0129	dihydroxy-acid dehydratase activity
I6K18_RS19255	COG0800	Aldolase
I6K18_RS19265	COG3141	response to X-ray
I6K18_RS19275	COG2979	Protein of unknown function (DUF533)
I6K18_RS19290	COG1770	oligopeptidase
I6K18_RS19295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K18_RS19300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K18_RS19310	COG2372	response to copper ion
I6K18_RS19315	COG1276	copper resistance
I6K18_RS19325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K18_RS19345	COG3008	intermembrane lipid transfer
I6K18_RS19350	COG2995	paraquat-inducible protein a
I6K18_RS19355	COG1956	GAF domain-containing protein
I6K18_RS19365	COG0793	Belongs to the peptidase S41A family
I6K18_RS19375	COG2814	Major facilitator Superfamily
I6K18_RS19380	COG1414	Transcriptional regulator
I6K18_RS19410	COG2226	methyltransferase
I6K18_RS19425	COG3716	PTS system mannose fructose sorbose family IID component
I6K18_RS19430	COG3715	PTS system
I6K18_RS19435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS19435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS19440	COG1253	flavin adenine dinucleotide binding
I6K18_RS19445	COG2200	EAL domain
I6K18_RS19450	COG1760	l-serine dehydratase
I6K18_RS19460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K18_RS19475	COG0251	oxidation-reduction process
I6K18_RS19480	COG1199	ATP-dependent helicase activity
I6K18_RS19485	COG1214	PFAM Peptidase M22, glycoprotease
I6K18_RS19490	COG3065	identical protein binding
I6K18_RS19495	COG0318	PFAM AMP-dependent synthetase and ligase
I6K18_RS19500	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K18_RS19505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K18_RS19510	COG4638	Rieske (2fe-2S)
I6K18_RS19520	COG0473	3-isopropylmalate dehydrogenase activity
I6K18_RS19525	COG0583	DNA-binding transcription factor activity
I6K18_RS19535	COG3615	Tellurite resistance protein tehB
I6K18_RS19545	COG2261	transglycosylase associated protein
I6K18_RS19560	COG2203	Gaf domain
I6K18_RS19560	COG2199	diguanylate cyclase activity
I6K18_RS19565	COG3042	response to heat
I6K18_RS19570	COG3189	MarR family transcriptional regulator
I6K18_RS19575	COG2807	transmembrane transport
I6K18_RS19580	COG2207	Transcriptional regulator
I6K18_RS19595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K18_RS19600	COG2199	diguanylate cyclase activity
I6K18_RS19605	COG2199	diguanylate cyclase activity
I6K18_RS19615	COG2766	serine protein kinase
I6K18_RS19620	COG3713	MltA-interacting MipA family protein
I6K18_RS19625	COG0656	L-ascorbic acid biosynthetic process
I6K18_RS19630	COG0676	glucose-6-phosphate 1-epimerase activity
I6K18_RS19635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K18_RS19645	COG3139	Protein of unknown function (DUF1315)
I6K18_RS19650	COG1063	alcohol dehydrogenase
I6K18_RS19655	COG2271	Major facilitator Superfamily
I6K18_RS19660	COG1063	alcohol dehydrogenase
I6K18_RS19665	COG0191	fructose-bisphosphate aldolase activity
I6K18_RS19670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K18_RS19675	COG0667	Aldo Keto reductase
I6K18_RS19680	COG1349	DNA-binding transcription factor activity
I6K18_RS19685	COG2814	Major facilitator Superfamily
I6K18_RS19690	COG1335	isochorismatase
I6K18_RS19695	COG0252	asparaginase activity
I6K18_RS19700	COG0616	signal peptide processing
I6K18_RS19705	COG0778	Nitroreductase
I6K18_RS19715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K18_RS19720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K18_RS19730	COG0494	nUDIX hydrolase
I6K18_RS19735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K18_RS19740	COG2897	thiosulfate sulfurtransferase activity
I6K18_RS19745	COG4136	ATPase activity
I6K18_RS19750	COG4135	transport system, permease component
I6K18_RS19755	COG4134	Bacterial extracellular solute-binding protein
I6K18_RS19760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K18_RS19765	COG0398	Pfam SNARE associated Golgi protein
I6K18_RS19775	COG0398	Pfam SNARE associated Golgi protein
I6K18_RS19780	COG0708	Exodeoxyribonuclease III
I6K18_RS19810	COG3678	ATP-independent chaperone mediated protein folding
I6K18_RS19820	COG0322	excinuclease ABC activity
I6K18_RS19830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K18_RS19835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K18_RS19840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K18_RS19845	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K18_RS19850	COG1917	Cupin 2, conserved barrel domain protein
I6K18_RS19850	COG2169	Transcriptional regulator
I6K18_RS19855	COG1486	melibiose metabolic process
I6K18_RS19865	COG0753	catalase activity
I6K18_RS19880	COG1823	symporter activity
I6K18_RS19885	COG1988	membrane-bound metal-dependent
I6K18_RS19890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K18_RS19900	COG3001	Fructosamine kinase
I6K18_RS19910	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K18_RS19915	COG3137	Salt-induced outer membrane protein
I6K18_RS20025	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K18_RS20035	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS20115	COG4695	Portal protein
I6K18_RS20125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6K18_RS20190	COG4974	Belongs to the 'phage' integrase family
I6K18_RS20210	COG0386	Belongs to the glutathione peroxidase family
I6K18_RS20220	COG0791	NLP P60 protein
I6K18_RS20225	COG2200	EAL domain
I6K18_RS20235	COG4256	Hemin uptake protein
I6K18_RS20240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K18_RS20250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K18_RS20250	COG0574	Belongs to the PEP-utilizing enzyme family
I6K18_RS20255	COG0318	PFAM AMP-dependent synthetase and ligase
I6K18_RS20260	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K18_RS20265	COG0644	oxidoreductase
I6K18_RS20270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K18_RS20275	COG2086	electron transfer activity
I6K18_RS20280	COG2207	Transcriptional regulator
I6K18_RS20280	COG1917	Cupin 2, conserved barrel domain protein
I6K18_RS20285	COG1960	acyl-CoA dehydrogenase activity
I6K18_RS20290	COG4670	ketone body catabolic process
I6K18_RS20305	COG2271	Major facilitator Superfamily
I6K18_RS20310	COG0738	Major facilitator superfamily
I6K18_RS20325	COG0628	permease
I6K18_RS20330	COG0247	lactate metabolic process
I6K18_RS20330	COG0277	FAD linked oxidase domain protein
I6K18_RS20335	COG2050	protein possibly involved in aromatic compounds catabolism
I6K18_RS20345	COG0316	Belongs to the HesB IscA family
I6K18_RS20350	COG0719	Fe-S assembly protein
I6K18_RS20355	COG0396	ATPase activity
I6K18_RS20360	COG0719	Fe-S assembly protein
I6K18_RS20375	COG1376	ErfK ybiS ycfS ynhG family protein
I6K18_RS20380	COG4238	major outer membrane lipoprotein
I6K18_RS20385	COG0469	pyruvate kinase activity
I6K18_RS20395	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS20400	COG2414	aldehyde ferredoxin oxidoreductase
I6K18_RS20410	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS20415	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6K18_RS20425	COG4529	Protein conserved in bacteria
I6K18_RS20445	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS20455	COG0307	riboflavin synthase, alpha
I6K18_RS20460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K18_RS20465	COG2814	Major facilitator Superfamily
I6K18_RS20470	COG0583	DNA-binding transcription factor activity
I6K18_RS20485	COG2814	Major facilitator Superfamily
I6K18_RS20490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K18_RS20495	COG0791	NLP P60 protein
I6K18_RS20500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K18_RS20505	COG1201	RNA secondary structure unwinding
I6K18_RS20515	COG0346	lactoylglutathione lyase activity
I6K18_RS20520	COG1902	pentaerythritol trinitrate reductase activity
I6K18_RS20525	COG1309	transcriptional regulator
I6K18_RS20530	COG3313	Fe-S protein
I6K18_RS20535	COG4989	oxidoreductase activity
I6K18_RS20540	COG2032	superoxide dismutase activity
I6K18_RS20545	COG1289	transmembrane transporter activity
I6K18_RS20550	COG1566	PFAM secretion protein HlyD family protein
I6K18_RS20565	COG3133	Outer membrane lipoprotein
I6K18_RS20575	COG3895	Periplasmic Protein
I6K18_RS20590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6K18_RS20595	COG0625	glutathione transferase activity
I6K18_RS20600	COG3104	oligopeptide transport
I6K18_RS20605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K18_RS20615	COG4659	FMN binding
I6K18_RS20655	COG0673	inositol 2-dehydrogenase activity
I6K18_RS20665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K18_RS20670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS20670	COG1263	PTS System
I6K18_RS20675	COG1609	Transcriptional regulator
I6K18_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS20685	COG1309	transcriptional regulator
I6K18_RS20690	COG3250	beta-galactosidase activity
I6K18_RS20705	COG5339	Protein conserved in bacteria
I6K18_RS20710	COG1482	cell wall glycoprotein biosynthetic process
I6K18_RS20715	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS20715	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K18_RS20720	COG0114	fumarate hydratase activity
I6K18_RS20730	COG2205	protein histidine kinase activity
I6K18_RS20735	COG0745	RESPONSE REGULATOR receiver
I6K18_RS20740	COG3136	membrane protein required for alginate biosynthesis
I6K18_RS20750	COG0531	amino acid
I6K18_RS20760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K18_RS20765	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K18_RS20770	COG0628	permease
I6K18_RS20785	COG3591	Belongs to the peptidase S1B family
I6K18_RS20800	COG2814	Major facilitator Superfamily
I6K18_RS20805	COG0583	DNA-binding transcription factor activity
I6K18_RS20810	COG1940	carbohydrate kinase activity
I6K18_RS20815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K18_RS20825	COG3381	protein complex oligomerization
I6K18_RS20830	COG3302	dmso reductase anchor subunit
I6K18_RS20835	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS20840	COG0243	molybdopterin cofactor binding
I6K18_RS20845	COG0243	molybdopterin cofactor binding
I6K18_RS20860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K18_RS20875	COG4948	Mandelate Racemase Muconate Lactonizing
I6K18_RS20880	COG1063	alcohol dehydrogenase
I6K18_RS20890	COG0582	viral genome integration into host DNA
I6K18_RS20900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K18_RS20925	COG1396	sequence-specific DNA binding
I6K18_RS20940	COG1846	Transcriptional regulator
I6K18_RS20970	COG1403	HNH endonuclease
I6K18_RS20975	COG0484	heat shock protein binding
I6K18_RS20985	COG1278	Cold shock
I6K18_RS20990	COG1278	Cold shock
I6K18_RS21005	COG3772	lysozyme
I6K18_RS21015	COG1278	Cold shock
I6K18_RS21040	COG5562	phage envelope protein
I6K18_RS21070	COG0740	serine-type endopeptidase activity
I6K18_RS21145	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS21150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K18_RS21155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K18_RS21175	COG0246	Mannitol dehydrogenase
I6K18_RS21185	COG1802	Transcriptional regulator
I6K18_RS21190	COG4221	oxidoreductase activity
I6K18_RS21195	COG0339	signal peptide processing
I6K18_RS21200	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K18_RS21205	COG3706	GGDEF domain
I6K18_RS21215	COG2814	Major facilitator Superfamily
I6K18_RS21220	COG0697	spore germination
I6K18_RS21230	COG4977	sequence-specific DNA binding
I6K18_RS21235	COG1846	Transcriptional regulator
I6K18_RS21255	COG0583	DNA-binding transcription factor activity
I6K18_RS21260	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS21265	COG2066	Belongs to the glutaminase family
I6K18_RS21275	COG2199	diguanylate cyclase activity
I6K18_RS21285	COG3781	membrane
I6K18_RS21335	COG2911	Protein conserved in bacteria
I6K18_RS21335	COG3210	domain, Protein
I6K18_RS21340	COG1396	sequence-specific DNA binding
I6K18_RS21345	COG3550	peptidyl-serine autophosphorylation
I6K18_RS21365	COG0656	L-ascorbic acid biosynthetic process
I6K18_RS21385	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K18_RS21390	COG0667	Aldo Keto reductase
I6K18_RS21410	COG3539	Fimbrial protein
I6K18_RS21420	COG3188	usher protein
I6K18_RS21425	COG3539	Fimbrial protein
I6K18_RS21430	COG3539	Fimbrial protein
I6K18_RS21435	COG3539	Fimbrial protein
I6K18_RS21440	COG0243	molybdopterin cofactor binding
I6K18_RS21450	COG2207	Transcriptional regulator
I6K18_RS21455	COG3119	arylsulfatase activity
I6K18_RS21460	COG0641	radical SAM
I6K18_RS21470	COG4178	(ABC) transporter
I6K18_RS21475	COG4771	TonB-dependent receptor
I6K18_RS21480	COG0612	Peptidase, M16
I6K18_RS21485	COG0076	glutamate decarboxylase activity
I6K18_RS21490	COG0531	amino acid
I6K18_RS21495	COG1649	PFAM Uncharacterised BCR, COG1649
I6K18_RS21510	COG2202	Pas domain
I6K18_RS21510	COG2200	EAL domain
I6K18_RS21510	COG2199	diguanylate cyclase activity
I6K18_RS21515	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6K18_RS21520	COG0747	negative chemotaxis
I6K18_RS21525	COG0601	transmembrane transport
I6K18_RS21530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K18_RS21535	COG0444	Belongs to the ABC transporter superfamily
I6K18_RS21540	COG4608	Belongs to the ABC transporter superfamily
I6K18_RS21545	COG1764	response to oxidative stress
I6K18_RS21565	COG1064	alcohol dehydrogenase
I6K18_RS21575	COG3093	addiction module antidote protein HigA
I6K18_RS21580	COG2864	formate dehydrogenase
I6K18_RS21585	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS21595	COG0697	spore germination
I6K18_RS21605	COG4886	Leucine-rich repeat (LRR) protein
I6K18_RS21610	COG4886	Leucine-rich repeat (LRR) protein
I6K18_RS21615	COG2223	nitrite transmembrane transporter activity
I6K18_RS21620	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K18_RS21625	COG1140	nitrate reductase beta subunit
I6K18_RS21630	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K18_RS21635	COG2181	nitrate reductase activity
I6K18_RS21640	COG0384	phenazine biosynthesis protein PhzF
I6K18_RS21650	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K18_RS21655	COG3039	Transposase
I6K18_RS21660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K18_RS21700	COG0625	glutathione transferase activity
I6K18_RS21705	COG1113	amino acid transport
I6K18_RS21710	COG3391	amine dehydrogenase activity
I6K18_RS21715	COG4772	TonB-dependent receptor
I6K18_RS21720	COG1802	Transcriptional regulator
I6K18_RS21725	COG2130	NADP-dependent
I6K18_RS21730	COG1247	-acetyltransferase
I6K18_RS21735	COG3238	Protein conserved in bacteria
I6K18_RS21765	COG1177	transmembrane transport
I6K18_RS21770	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K18_RS21775	COG3842	ATPase activity
I6K18_RS21780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K18_RS21785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K18_RS21790	COG1598	PFAM Uncharacterised protein family UPF0150
I6K18_RS21795	COG1724	mRNA binding
I6K18_RS21805	COG0826	peptidase U32
I6K18_RS21810	COG1396	sequence-specific DNA binding
I6K18_RS21815	COG3135	benzoate transporter
I6K18_RS21825	COG0500	methyltransferase
I6K18_RS21830	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K18_RS21835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K18_RS21840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K18_RS21845	COG2841	Protein conserved in bacteria
I6K18_RS21855	COG5383	Protein conserved in bacteria
I6K18_RS21860	COG0583	DNA-binding transcription factor activity
I6K18_RS21865	COG0840	transmembrane signaling receptor activity
I6K18_RS21880	COG3038	cytochrome b561
I6K18_RS21885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K18_RS21890	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS21895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K18_RS21910	COG1643	Atp-dependent helicase
I6K18_RS21920	COG0671	phosphoesterase, PA-phosphatase related
I6K18_RS21920	COG2453	phosphatase
I6K18_RS21930	COG4589	Belongs to the CDS family
I6K18_RS21935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K18_RS21945	COG0667	Aldo Keto reductase
I6K18_RS21955	COG3784	Protein of unknown function (DUF1318)
I6K18_RS21965	COG2911	Protein conserved in bacteria
I6K18_RS21970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K18_RS21975	COG3187	Heat shock protein
I6K18_RS21980	COG3042	response to heat
I6K18_RS21985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K18_RS21985	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K18_RS21985	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K18_RS21985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K18_RS21990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K18_RS21995	COG0589	response to stress
I6K18_RS22005	COG0513	Belongs to the DEAD box helicase family
I6K18_RS22020	COG3706	GGDEF domain
I6K18_RS22025	COG2840	Smr protein MutS2
I6K18_RS22030	COG0583	DNA-binding transcription factor activity
I6K18_RS22035	COG1473	amidohydrolase
I6K18_RS22040	COG1473	amidohydrolase
I6K18_RS22045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6K18_RS22050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K18_RS22055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K18_RS22060	COG0589	response to stress
I6K18_RS22065	COG3182	Iron-regulated membrane protein
I6K18_RS22070	COG0668	transmembrane transport
I6K18_RS22075	COG4166	transmembrane transport
I6K18_RS22080	COG0583	DNA-binding transcription factor activity
I6K18_RS22085	COG1073	alpha beta
I6K18_RS22090	COG0702	epimerase
I6K18_RS22095	COG2866	Carboxypeptidase
I6K18_RS22100	COG4948	Mandelate Racemase Muconate Lactonizing
I6K18_RS22105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K18_RS22110	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6K18_RS22120	COG3106	COG3106 Predicted ATPase
I6K18_RS22125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K18_RS22135	COG1983	PspC domain protein
I6K18_RS22145	COG1842	Phage shock protein A
I6K18_RS22150	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K18_RS22155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K18_RS22160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K18_RS22165	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS22170	COG1396	sequence-specific DNA binding
I6K18_RS22170	COG1917	Cupin 2, conserved barrel domain protein
I6K18_RS22175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K18_RS22180	COG0174	glutamine synthetase
I6K18_RS22190	COG0531	amino acid
I6K18_RS22200	COG4166	transmembrane transport
I6K18_RS22205	COG4168	peptide transport system, permease
I6K18_RS22210	COG4171	peptide transport system, permease
I6K18_RS22215	COG4172	Belongs to the ABC transporter superfamily
I6K18_RS22220	COG4172	Belongs to the ABC transporter superfamily
I6K18_RS22225	COG2852	Protein conserved in bacteria
I6K18_RS22230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K18_RS22235	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K18_RS22235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K18_RS22250	COG5001	Diguanylate cyclase
I6K18_RS22260	COG1349	DNA-binding transcription factor activity
I6K18_RS22270	COG0023	Translation Initiation Factor
I6K18_RS22280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K18_RS22285	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K18_RS22290	COG0671	phosphoesterase, PA-phosphatase related
I6K18_RS22300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K18_RS22320	COG0583	DNA-binding transcription factor activity
I6K18_RS22330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K18_RS22340	COG0616	signal peptide processing
I6K18_RS22345	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS22350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K18_RS22355	COG1187	pseudouridine synthase activity
I6K18_RS22360	COG4907	membrane protein (DUF2207)
I6K18_RS22365	COG0009	L-threonylcarbamoyladenylate synthase
I6K18_RS22370	COG0613	PHP domain protein
I6K18_RS22380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K18_RS22385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K18_RS22385	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K18_RS22390	COG0134	indole-3-glycerol-phosphate synthase activity
I6K18_RS22390	COG0135	phosphoribosylanthranilate isomerase activity
I6K18_RS22405	COG3729	General stress protein
I6K18_RS22410	COG3685	Protein conserved in bacteria
I6K18_RS22415	COG3685	Protein conserved in bacteria
I6K18_RS22420	COG3047	cAMP biosynthetic process
I6K18_RS22440	COG1607	acyl-coa hydrolase
I6K18_RS22445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6K18_RS22450	COG2350	Protein conserved in bacteria
I6K18_RS22455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K18_RS22475	COG4608	Belongs to the ABC transporter superfamily
I6K18_RS22480	COG0444	Belongs to the ABC transporter superfamily
I6K18_RS22485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K18_RS22490	COG0601	transmembrane transport
I6K18_RS22495	COG4166	transmembrane transport
I6K18_RS22500	COG2095	MarC family integral membrane protein
I6K18_RS22505	COG1012	belongs to the aldehyde dehydrogenase family
I6K18_RS22505	COG1454	alcohol dehydrogenase
I6K18_RS22510	COG1435	thymidine kinase activity
I6K18_RS22525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K18_RS22530	COG0745	RESPONSE REGULATOR receiver
I6K18_RS22535	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K18_RS22545	COG0788	formyltetrahydrofolate deformylase activity
I6K18_RS22570	COG2181	nitrate reductase activity
I6K18_RS22575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K18_RS22580	COG1140	nitrate reductase beta subunit
I6K18_RS22585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K18_RS22590	COG2223	nitrite transmembrane transporter activity
I6K18_RS22595	COG3850	Histidine kinase
I6K18_RS22600	COG2197	response regulator
I6K18_RS22605	COG4932	domain protein
I6K18_RS22610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K18_RS22615	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K18_RS22620	COG4572	Cation transport regulator
I6K18_RS22625	COG0387	Pfam Sodium calcium exchanger
I6K18_RS22645	COG2912	Transglutaminase-like superfamily
I6K18_RS22650	COG3094	Invasion gene expression up-regulator, SirB
I6K18_RS22655	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K18_RS22680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K18_RS22685	COG0659	secondary active sulfate transmembrane transporter activity
I6K18_RS22700	COG0012	GTP binding
I6K18_RS22705	COG3468	outer membrane autotransporter barrel domain protein
I6K18_RS22710	COG3284	Transcriptional regulator
I6K18_RS22715	COG2376	Dihydroxyacetone kinase
I6K18_RS22720	COG1461	Dihydroxyacetone kinase
I6K18_RS22725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K18_RS22725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K18_RS22725	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K18_RS22735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K18_RS22740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K18_RS22745	COG1120	ATPase activity
I6K18_RS22750	COG0500	methyltransferase
I6K18_RS22755	COG0157	Belongs to the NadC ModD family
I6K18_RS22770	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K18_RS22780	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K18_RS22800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K18_RS22810	COG2719	SpoVR family
I6K18_RS22825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6K18_RS22830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K18_RS22835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K18_RS22850	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K18_RS22880	COG2894	cell division
I6K18_RS22955	COG2200	EAL domain
I6K18_RS22960	COG0789	Transcriptional regulator
I6K18_RS22965	COG5562	phage envelope protein
I6K18_RS22985	COG0538	isocitrate dehydrogenase activity
I6K18_RS23000	COG1121	(ABC) transporter
I6K18_RS23005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K18_RS23010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K18_RS23025	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS23030	COG3385	transposase activity
I6K18_RS23060	COG1196	nuclear chromosome segregation
I6K18_RS23110	COG1030	water channel activity
I6K18_RS23130	COG4220	transposase activity
I6K18_RS23150	COG3772	lysozyme
I6K18_RS23160	COG2207	Transcriptional regulator
I6K18_RS23165	COG3272	Protein of unknown function (DUF1722)
I6K18_RS23325	COG0582	viral genome integration into host DNA
I6K18_RS23330	COG0538	isocitrate dehydrogenase activity
I6K18_RS23335	COG1187	pseudouridine synthase activity
I6K18_RS23355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K18_RS23365	COG2205	protein histidine kinase activity
I6K18_RS23370	COG2850	peptidyl-arginine hydroxylation
I6K18_RS23380	COG3842	ATPase activity
I6K18_RS23395	COG0500	methyltransferase
I6K18_RS23415	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K18_RS23520	COG4220	transposase activity
I6K18_RS23550	COG3772	lysozyme
I6K18_RS23600	COG0484	heat shock protein binding
I6K18_RS23605	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K18_RS23610	COG1403	HNH endonuclease
I6K18_RS23690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K18_RS23700	COG0582	viral genome integration into host DNA
I6K18_RS23705	COG1177	transmembrane transport
I6K18_RS23710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K18_RS23720	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K18_RS23725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K18_RS23735	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K18_RS23745	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K18_RS23750	COG4763	Acyl-transferase
I6K18_RS23755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K18_RS23760	COG1376	ErfK ybiS ycfS ynhG family protein
I6K18_RS23760	COG1388	LysM domain
I6K18_RS23770	COG1309	transcriptional regulator
I6K18_RS23775	COG3134	Outer membrane lipoprotein
I6K18_RS23780	COG1252	NADH dehydrogenase
I6K18_RS23800	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6K18_RS23805	COG5633	Lipoprotein
I6K18_RS23810	COG0537	adenosine 5'-monophosphoramidase activity
I6K18_RS23815	COG4773	Receptor
I6K18_RS23820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K18_RS23820	COG1263	PTS System
I6K18_RS23825	COG0084	hydrolase, TatD family'
I6K18_RS23830	COG0470	DNA polymerase III
I6K18_RS23840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K18_RS23845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K18_RS23855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K18_RS23865	COG1028	Short-chain dehydrogenase reductase Sdr
I6K18_RS23870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K18_RS23890	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K18_RS23895	COG0424	maF-like protein
I6K18_RS23900	COG0564	pseudouridine synthase activity
I6K18_RS23905	COG1530	ribonuclease E activity
I6K18_RS23920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K18_RS23925	COG1256	bacterial-type flagellum assembly
I6K18_RS23930	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K18_RS23930	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6K18_RS23945	COG4786	Flagellar basal body rod
I6K18_RS23950	COG4787	bacterial-type flagellum-dependent cell motility
I6K18_RS23955	COG1749	Flagellar hook protein flgE
I6K18_RS23960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6K18_RS23965	COG1558	bacterial-type flagellum-dependent cell motility
I6K18_RS23970	COG1815	bacterial-type flagellum-dependent cell motility
I6K18_RS23975	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6K18_RS23980	COG2747	anti-sigma28 factor FlgM
I6K18_RS23985	COG3418	PFAM FlgN family protein
I6K18_RS23990	COG0728	peptidoglycan biosynthetic process
I6K18_RS23995	COG0673	inositol 2-dehydrogenase activity
I6K18_RS24005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K18_RS24015	COG2999	glutathione oxidoreductase activity
I6K18_RS24050	COG3038	cytochrome b561
I6K18_RS24065	COG1560	Kdo2-lipid A biosynthetic process
I6K18_RS24080	COG5645	(Lipo)protein
I6K18_RS24085	COG2943	transferase activity, transferring hexosyl groups
I6K18_RS24100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K18_RS24105	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K18_RS24130	COG2197	response regulator
I6K18_RS24145	COG1462	curli production assembly transport component CsgG
I6K18_RS24155	COG3381	protein complex oligomerization
I6K18_RS24180	COG1702	phosphate starvation-inducible protein PhoH
I6K18_RS24190	COG2822	iron ion transport
I6K18_RS24205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K18_RS24215	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K18_RS24215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K18_RS24215	COG0506	proline dehydrogenase activity
I6K18_RS24220	COG1309	transcriptional regulator
I6K18_RS24255	COG2233	PERMEase
I6K18_RS24260	COG3729	General stress protein
I6K18_RS24300	COG0243	molybdopterin cofactor binding
I6K18_RS24305	COG3005	denitrification pathway
I6K18_RS24310	COG0745	RESPONSE REGULATOR receiver
I6K18_RS24315	COG1879	ABC-type sugar transport system periplasmic component
I6K18_RS24320	COG2198	Histidine kinase
I6K18_RS24320	COG2205	protein histidine kinase activity
I6K18_RS24320	COG0784	Response regulator, receiver
I6K18_RS24325	COG0348	domain, Protein
I6K18_RS24345	COG1278	Cold shock
I6K18_RS24350	COG1278	Cold shock
I6K18_RS24365	COG1294	oxidase, subunit
I6K18_RS24370	COG1271	oxidase subunit
I6K18_RS24375	COG1773	rubredoxin
I6K18_RS24380	COG1999	signal sequence binding
I6K18_RS24385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K18_RS24390	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6K18_RS24395	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K18_RS24400	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K18_RS24410	COG0670	Belongs to the BI1 family
I6K18_RS24415	COG2920	part of a sulfur-relay system
I6K18_RS24420	COG1254	Belongs to the acylphosphatase family
I6K18_RS24435	COG1832	CoA-binding protein
I6K18_RS24450	COG0210	DNA helicase
I6K18_RS24455	COG3304	Inner membrane component domain
I6K18_RS24460	COG1289	transmembrane transporter activity
I6K18_RS24465	COG3070	regulator of competence-specific genes
I6K18_RS24475	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K18_RS24475	COG2885	chlorophyll binding
I6K18_RS24485	COG1067	ATP-dependent peptidase activity
I6K18_RS24495	COG3130	regulation of translation
I6K18_RS24500	COG3009	Protein conserved in bacteria
I6K18_RS24505	COG3008	intermembrane lipid transfer
I6K18_RS24505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K18_RS24510	COG2995	paraquat-inducible protein a
I6K18_RS24515	COG0488	(ABC) transporter
I6K18_RS24525	COG3217	Mosc domain protein beta barrel domain protein
I6K18_RS24525	COG0633	Ferredoxin
I6K18_RS24550	COG0431	NADPH-dependent FMN reductase
I6K18_RS24555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K18_RS24565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K18_RS24580	COG0308	aminopeptidase N
I6K18_RS24600	COG1448	Aminotransferase
I6K18_RS24605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K18_RS24610	COG3108	Peptidase M15
I6K18_RS24615	COG2989	Protein conserved in bacteria
I6K18_RS24625	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K18_RS24635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K18_RS24640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K18_RS24645	COG3173	Aminoglycoside phosphotransferase
I6K18_RS24660	COG3214	Protein conserved in bacteria
I6K18_RS24675	COG2333	competence protein COMEC
I6K18_RS24675	COG0658	competence protein
I6K18_RS24685	COG0539	negative regulation of cytoplasmic translation
I6K18_RS24695	COG0501	Belongs to the peptidase M48B family
I6K18_RS24710	COG2323	membrane
I6K18_RS24715	COG1944	ATP diphosphatase activity
I6K18_RS24720	COG2116	formate transmembrane transporter activity
I6K18_RS24725	COG1882	Formate acetyltransferase
I6K18_RS24730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K18_RS24740	COG0531	amino acid
I6K18_RS24750	COG1335	isochorismatase
I6K18_RS24755	COG3302	dmso reductase anchor subunit
I6K18_RS24760	COG0437	4 iron, 4 sulfur cluster binding
I6K18_RS24765	COG0243	molybdopterin cofactor binding
I6K18_RS24775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K18_RS24785	COG1178	ABC-type Fe3 transport system permease component
I6K18_RS24785	COG1674	ftsk spoiiie
I6K18_RS24790	COG1522	sequence-specific DNA binding
I6K18_RS24795	COG0492	ferredoxin-NADP+ reductase activity
I6K18_RS24800	COG4988	ABC transporter
I6K18_RS24805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K18_RS24830	COG0542	response to heat
I6K18_RS24840	COG1278	Cold shock
I6K18_RS24850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K18_RS24855	COG2990	Protein conserved in bacteria
I6K18_RS24860	COG3593	DNA synthesis involved in DNA repair
I6K18_RS24865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K18_RS24870	COG2431	L-lysine efflux transmembrane transporter activity
I6K18_RS24880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K18_RS24885	COG0028	Belongs to the TPP enzyme family
I6K18_RS24890	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K18_RS24895	COG0702	epimerase
I6K18_RS24900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K18_RS24905	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K18_RS24925	COG1126	abc transporter atp-binding protein
I6K18_RS24930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS24935	COG4215	(ABC) transporter
I6K18_RS24940	COG4160	amino acid transport
I6K18_RS24945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS24975	COG1177	transmembrane transport
I6K18_RS24980	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K18_RS24985	COG3842	ATPase activity
I6K18_RS24990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K18_RS25005	COG0778	Nitroreductase
I6K18_RS25015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K18_RS25035	COG3385	transposase activity
I6K18_RS25045	COG0738	Major facilitator superfamily
I6K18_RS25050	COG0561	phosphatase activity
I6K18_RS25060	COG2814	Major facilitator Superfamily
I6K18_RS25065	COG0671	phosphoesterase, PA-phosphatase related
I6K18_RS25070	COG1349	DNA-binding transcription factor activity
I6K18_RS25075	COG1686	Belongs to the peptidase S11 family
I6K18_RS25080	COG0625	glutathione transferase activity
I6K18_RS25085	COG2133	pyrroloquinoline quinone binding
I6K18_RS25110	COG2199	diguanylate cyclase activity
I6K18_RS25130	COG0747	negative chemotaxis
I6K18_RS25140	COG1446	asparaginase
I6K18_RS25145	COG0303	'Molybdopterin
I6K18_RS25150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K18_RS25155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K18_RS25160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K18_RS25165	COG1882	Formate acetyltransferase
I6K18_RS25170	COG0561	phosphatase activity
I6K18_RS25185	COG2271	Major facilitator Superfamily
I6K18_RS25195	COG0488	(ABC) transporter
I6K18_RS25200	COG1376	ErfK ybiS ycfS ynhG family protein
I6K18_RS25205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K18_RS25210	COG1321	iron dependent repressor
I6K18_RS25220	COG2194	sulfuric ester hydrolase activity
I6K18_RS25225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K18_RS25235	COG5006	permease, DMT superfamily
I6K18_RS25245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K18_RS25250	COG0765	amino acid transport
I6K18_RS25255	COG1126	abc transporter atp-binding protein
I6K18_RS25260	COG0668	transmembrane transport
I6K18_RS25285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K18_RS25295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K18_RS25300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K18_RS25305	COG1199	ATP-dependent helicase activity
I6K18_RS25310	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I6K18_RS25315	COG0513	Belongs to the DEAD box helicase family
I6K18_RS25320	COG1309	transcriptional regulator
I6K18_RS25330	COG1131	(ABC) transporter
I6K18_RS25335	COG0842	Transport permease protein
I6K18_RS25340	COG0842	Transport permease protein
I6K18_RS25350	COG3568	Endonuclease Exonuclease Phosphatase
I6K18_RS25355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K18_RS25360	COG0392	lysyltransferase activity
I6K18_RS25365	COG0670	Belongs to the BI1 family
I6K18_RS25370	COG0670	Belongs to the BI1 family
I6K18_RS25375	COG0314	molybdopterin synthase activity
I6K18_RS25380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K18_RS25390	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K18_RS25400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K18_RS25410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K18_RS25415	COG2226	methyltransferase
I6K18_RS25430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K18_RS25435	COG1881	PFAM PEBP family protein
I6K18_RS25440	COG2246	polysaccharide biosynthetic process
I6K18_RS25455	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K18_RS25530	COG1185	polyribonucleotide nucleotidyltransferase activity
I6K18_RS25655	COG1560	Kdo2-lipid A biosynthetic process
I6K18_RS25665	COG0436	Aminotransferase
I6K18_RS25670	COG3275	phosphorelay sensor kinase activity
I6K18_RS25675	COG3279	Response regulator of the LytR AlgR family
I6K18_RS25680	COG2207	Transcriptional regulator
I6K18_RS25690	COG1363	Peptidase, m42
I6K18_RS25695	COG0006	proline dipeptidase activity
I6K18_RS25700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS25705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K18_RS25810	COG5001	Diguanylate cyclase
I6K18_RS25810	COG3300	MHYT domain
I6K18_RS25915	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6K18_RS25990	COG3039	Transposase
I6K18_RS26305	COG3039	Transposase
I6K18_RS26310	COG0833	amino acid
I6K18_RS26315	COG2040	homocysteine
I6K18_RS26385	COG1414	Transcriptional regulator
I6K18_RS26410	COG1175	transmembrane transport
I6K18_RS26415	COG0395	ABC-type sugar transport system, permease component
I6K18_RS26420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K18_RS26425	COG3842	ATPase activity
I6K18_RS26450	COG3344	reverse transcriptase
I6K18_RS26480	COG1136	(ABC) transporter
I6K18_RS26480	COG0577	efflux transmembrane transporter activity
I6K18_RS26485	COG0577	efflux transmembrane transporter activity
I6K18_RS26485	COG1136	(ABC) transporter
I6K18_RS26490	COG0577	efflux transmembrane transporter activity
I6K18_RS26490	COG1136	(ABC) transporter
I6K18_RS26505	COG0672	)-iron permease
I6K18_RS26510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K18_RS26515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K18_RS26560	COG0640	Transcriptional regulator
I6K18_RS26725	COG3300	MHYT domain
I6K18_RS26725	COG5001	Diguanylate cyclase
I6K18_RS26835	COG3039	Transposase
I6K18_RS26860	COG2805	Type II/IV secretion system protein
I6K18_RS27055	COG1475	DNA binding
I6K18_RS27260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K18_RS27275	COG0741	lytic transglycosylase activity
I6K18_RS27295	COG0741	lytic transglycosylase activity
I6K18_RS27310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K18_RS27600	COG4372	Transposase
I6K18_RS27605	COG3436	PFAM IS66 Orf2 family protein
I6K18_RS27905	COG0489	protein tyrosine kinase activity
I6K18_RS27925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K18_RS27980	COG3504	Conjugal transfer protein