locus-tag	class	description
I6L01_RS00130	COG4220	transposase activity
I6L01_RS00160	COG3772	lysozyme
I6L01_RS00205	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6L01_RS00210	COG1403	HNH endonuclease
I6L01_RS00265	COG1846	Transcriptional regulator
I6L01_RS00290	COG1396	sequence-specific DNA binding
I6L01_RS00305	COG3646	Phage regulatory protein
I6L01_RS00320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L01_RS00330	COG0582	viral genome integration into host DNA
I6L01_RS00335	COG1177	transmembrane transport
I6L01_RS00340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L01_RS00350	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L01_RS00355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L01_RS00365	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L01_RS00375	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L01_RS00380	COG4763	Acyl-transferase
I6L01_RS00385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L01_RS00390	COG1388	LysM domain
I6L01_RS00390	COG1376	ErfK ybiS ycfS ynhG family protein
I6L01_RS00405	COG1309	transcriptional regulator
I6L01_RS00410	COG3134	Outer membrane lipoprotein
I6L01_RS00415	COG1252	NADH dehydrogenase
I6L01_RS00435	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6L01_RS00440	COG5633	Lipoprotein
I6L01_RS00445	COG0537	adenosine 5'-monophosphoramidase activity
I6L01_RS00450	COG4773	Receptor
I6L01_RS00455	COG1263	PTS System
I6L01_RS00455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS00460	COG0084	hydrolase, TatD family'
I6L01_RS00465	COG0470	DNA polymerase III
I6L01_RS00475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L01_RS00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L01_RS00490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L01_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS00505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L01_RS00525	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L01_RS00530	COG0424	maF-like protein
I6L01_RS00535	COG0564	pseudouridine synthase activity
I6L01_RS00540	COG1530	ribonuclease E activity
I6L01_RS00555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L01_RS00560	COG1256	bacterial-type flagellum assembly
I6L01_RS00565	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6L01_RS00565	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L01_RS00580	COG4786	Flagellar basal body rod
I6L01_RS00585	COG4787	bacterial-type flagellum-dependent cell motility
I6L01_RS00590	COG1749	Flagellar hook protein flgE
I6L01_RS00595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6L01_RS00600	COG1558	bacterial-type flagellum-dependent cell motility
I6L01_RS00605	COG1815	bacterial-type flagellum-dependent cell motility
I6L01_RS00610	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L01_RS00615	COG2747	anti-sigma28 factor FlgM
I6L01_RS00620	COG3418	PFAM FlgN family protein
I6L01_RS00625	COG0728	peptidoglycan biosynthetic process
I6L01_RS00630	COG0673	inositol 2-dehydrogenase activity
I6L01_RS00640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L01_RS00650	COG2999	glutathione oxidoreductase activity
I6L01_RS00685	COG3038	cytochrome b561
I6L01_RS00700	COG1560	Kdo2-lipid A biosynthetic process
I6L01_RS00715	COG5645	(Lipo)protein
I6L01_RS00720	COG2943	transferase activity, transferring hexosyl groups
I6L01_RS00735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L01_RS00740	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6L01_RS00765	COG2197	response regulator
I6L01_RS00780	COG1462	curli production assembly transport component CsgG
I6L01_RS00790	COG3381	protein complex oligomerization
I6L01_RS00810	COG3706	GGDEF domain
I6L01_RS00815	COG0457	Tetratricopeptide repeat
I6L01_RS00820	COG1649	PFAM Uncharacterised BCR, COG1649
I6L01_RS00820	COG0726	polysaccharide deacetylase
I6L01_RS00825	COG1215	transferase activity, transferring glycosyl groups
I6L01_RS00830	COG3658	cytochrome
I6L01_RS00835	COG1702	phosphate starvation-inducible protein PhoH
I6L01_RS00845	COG2822	iron ion transport
I6L01_RS00855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L01_RS00865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L01_RS00865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L01_RS00865	COG0506	proline dehydrogenase activity
I6L01_RS00870	COG1309	transcriptional regulator
I6L01_RS00905	COG2233	PERMEase
I6L01_RS00910	COG3729	General stress protein
I6L01_RS00950	COG3381	protein complex oligomerization
I6L01_RS00955	COG0243	molybdopterin cofactor binding
I6L01_RS00960	COG3005	denitrification pathway
I6L01_RS00965	COG0745	RESPONSE REGULATOR receiver
I6L01_RS00970	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS00975	COG2205	protein histidine kinase activity
I6L01_RS00975	COG2198	Histidine kinase
I6L01_RS00975	COG0784	Response regulator, receiver
I6L01_RS00980	COG0348	domain, Protein
I6L01_RS01000	COG1278	Cold shock
I6L01_RS01005	COG1278	Cold shock
I6L01_RS01020	COG1294	oxidase, subunit
I6L01_RS01025	COG1271	oxidase subunit
I6L01_RS01030	COG1773	rubredoxin
I6L01_RS01035	COG1999	signal sequence binding
I6L01_RS01040	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L01_RS01045	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6L01_RS01050	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L01_RS01055	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L01_RS01065	COG0670	Belongs to the BI1 family
I6L01_RS01070	COG2920	part of a sulfur-relay system
I6L01_RS01075	COG1254	Belongs to the acylphosphatase family
I6L01_RS01090	COG1832	CoA-binding protein
I6L01_RS01105	COG0210	DNA helicase
I6L01_RS01110	COG3304	Inner membrane component domain
I6L01_RS01115	COG1289	transmembrane transporter activity
I6L01_RS01120	COG3070	regulator of competence-specific genes
I6L01_RS01140	COG1067	ATP-dependent peptidase activity
I6L01_RS01150	COG3130	regulation of translation
I6L01_RS01155	COG3009	Protein conserved in bacteria
I6L01_RS01160	COG3008	intermembrane lipid transfer
I6L01_RS01160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L01_RS01165	COG2995	paraquat-inducible protein a
I6L01_RS01170	COG0488	(ABC) transporter
I6L01_RS01180	COG3217	Mosc domain protein beta barrel domain protein
I6L01_RS01180	COG0633	Ferredoxin
I6L01_RS01195	COG3121	Chaperone
I6L01_RS01200	COG3539	Fimbrial protein
I6L01_RS01205	COG3539	Fimbrial protein
I6L01_RS01210	COG3539	Fimbrial protein
I6L01_RS01215	COG3188	usher protein
I6L01_RS01220	COG3121	Chaperone
I6L01_RS01225	COG3539	Fimbrial protein
I6L01_RS01230	COG0431	NADPH-dependent FMN reductase
I6L01_RS01235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L01_RS01245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L01_RS01250	COG1116	anion transmembrane transporter activity
I6L01_RS01255	COG0308	aminopeptidase N
I6L01_RS01275	COG1448	Aminotransferase
I6L01_RS01280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L01_RS01285	COG3108	Peptidase M15
I6L01_RS01290	COG2989	Protein conserved in bacteria
I6L01_RS01300	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L01_RS01310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L01_RS01315	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L01_RS01320	COG3173	Aminoglycoside phosphotransferase
I6L01_RS01335	COG3214	Protein conserved in bacteria
I6L01_RS01345	COG1132	(ABC) transporter
I6L01_RS01350	COG2333	competence protein COMEC
I6L01_RS01350	COG0658	competence protein
I6L01_RS01360	COG0539	negative regulation of cytoplasmic translation
I6L01_RS01370	COG0501	Belongs to the peptidase M48B family
I6L01_RS01385	COG2323	membrane
I6L01_RS01390	COG1944	ATP diphosphatase activity
I6L01_RS01395	COG2116	formate transmembrane transporter activity
I6L01_RS01400	COG1882	Formate acetyltransferase
I6L01_RS01405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L01_RS01415	COG0531	amino acid
I6L01_RS01425	COG1335	isochorismatase
I6L01_RS01430	COG3302	dmso reductase anchor subunit
I6L01_RS01435	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS01440	COG0243	molybdopterin cofactor binding
I6L01_RS01450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L01_RS01460	COG1178	ABC-type Fe3 transport system permease component
I6L01_RS01460	COG1674	ftsk spoiiie
I6L01_RS01465	COG1522	sequence-specific DNA binding
I6L01_RS01470	COG0492	ferredoxin-NADP+ reductase activity
I6L01_RS01475	COG4988	ABC transporter
I6L01_RS01480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L01_RS01505	COG0542	response to heat
I6L01_RS01515	COG1278	Cold shock
I6L01_RS01525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS01530	COG2990	Protein conserved in bacteria
I6L01_RS01535	COG3593	DNA synthesis involved in DNA repair
I6L01_RS01540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L01_RS01545	COG2431	L-lysine efflux transmembrane transporter activity
I6L01_RS01555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L01_RS01560	COG0028	Belongs to the TPP enzyme family
I6L01_RS01565	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6L01_RS01570	COG0702	epimerase
I6L01_RS01575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L01_RS01580	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L01_RS01600	COG1126	abc transporter atp-binding protein
I6L01_RS01605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS01610	COG4215	(ABC) transporter
I6L01_RS01615	COG4160	amino acid transport
I6L01_RS01620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS01625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L01_RS01635	COG1177	transmembrane transport
I6L01_RS01640	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L01_RS01645	COG3842	ATPase activity
I6L01_RS01650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L01_RS01665	COG0778	Nitroreductase
I6L01_RS01675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L01_RS01690	COG3226	Transcriptional regulator
I6L01_RS01695	COG0738	Major facilitator superfamily
I6L01_RS01700	COG0561	phosphatase activity
I6L01_RS01710	COG2814	Major facilitator Superfamily
I6L01_RS01715	COG0671	phosphoesterase, PA-phosphatase related
I6L01_RS01720	COG1349	DNA-binding transcription factor activity
I6L01_RS01725	COG1686	Belongs to the peptidase S11 family
I6L01_RS01730	COG0625	glutathione transferase activity
I6L01_RS01735	COG2133	pyrroloquinoline quinone binding
I6L01_RS01760	COG2199	diguanylate cyclase activity
I6L01_RS01765	COG2200	EAL domain
I6L01_RS01780	COG0747	negative chemotaxis
I6L01_RS01790	COG1446	asparaginase
I6L01_RS01795	COG0303	'Molybdopterin
I6L01_RS01800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L01_RS01805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L01_RS01810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L01_RS01815	COG1882	Formate acetyltransferase
I6L01_RS01820	COG0561	phosphatase activity
I6L01_RS01835	COG2271	Major facilitator Superfamily
I6L01_RS01845	COG0488	(ABC) transporter
I6L01_RS01850	COG1376	ErfK ybiS ycfS ynhG family protein
I6L01_RS01855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6L01_RS01860	COG1321	iron dependent repressor
I6L01_RS01870	COG2194	sulfuric ester hydrolase activity
I6L01_RS01875	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L01_RS01885	COG5006	permease, DMT superfamily
I6L01_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS01900	COG0765	amino acid transport
I6L01_RS01905	COG1126	abc transporter atp-binding protein
I6L01_RS01910	COG0668	transmembrane transport
I6L01_RS01925	COG4774	siderophore transport
I6L01_RS01935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L01_RS01945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6L01_RS01950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L01_RS01955	COG1199	ATP-dependent helicase activity
I6L01_RS01970	COG0513	Belongs to the DEAD box helicase family
I6L01_RS01975	COG1309	transcriptional regulator
I6L01_RS01985	COG1131	(ABC) transporter
I6L01_RS01990	COG0842	Transport permease protein
I6L01_RS01995	COG0842	Transport permease protein
I6L01_RS02005	COG3568	Endonuclease Exonuclease Phosphatase
I6L01_RS02010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L01_RS02015	COG0392	lysyltransferase activity
I6L01_RS02020	COG0670	Belongs to the BI1 family
I6L01_RS02030	COG0670	Belongs to the BI1 family
I6L01_RS02035	COG0314	molybdopterin synthase activity
I6L01_RS02040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L01_RS02050	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L01_RS02060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6L01_RS02070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L01_RS02075	COG2226	methyltransferase
I6L01_RS02090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L01_RS02095	COG1881	PFAM PEBP family protein
I6L01_RS02100	COG4677	pectinesterase activity
I6L01_RS02110	COG0471	metal ion transport
I6L01_RS02115	COG2828	Protein conserved in bacteria
I6L01_RS02120	COG0583	DNA-binding transcription factor activity
I6L01_RS02130	COG0561	phosphatase activity
I6L01_RS02135	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L01_RS02140	COG4149	molybdate abc transporter
I6L01_RS02145	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L01_RS02155	COG3585	molybdate ion transport
I6L01_RS02155	COG2005	Transcriptional regulator
I6L01_RS02160	COG1119	ATPase activity
I6L01_RS02165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L01_RS02170	COG1085	galactose-1-phosphate uridylyltransferase
I6L01_RS02180	COG2017	converts alpha-aldose to the beta-anomer
I6L01_RS02190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L01_RS02200	COG1230	cation diffusion facilitator family transporter
I6L01_RS02205	COG3201	nicotinamide mononucleotide transporter
I6L01_RS02240	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L01_RS02245	COG2885	chlorophyll binding
I6L01_RS02255	COG3064	Membrane
I6L01_RS02260	COG0848	biopolymer transport protein
I6L01_RS02265	COG0811	peptide transport
I6L01_RS02270	COG0824	Thioesterase
I6L01_RS02275	COG3790	cyd operon protein YbgE
I6L01_RS02280	COG4890	Cyd operon protein YbgT
I6L01_RS02285	COG1294	oxidase, subunit
I6L01_RS02290	COG1271	oxidase subunit
I6L01_RS02305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6L01_RS02315	COG4865	methylaspartate mutase activity
I6L01_RS02320	COG3799	methylaspartate ammonia-lyase activity
I6L01_RS02335	COG1301	dicarboxylic acid transport
I6L01_RS02340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS02340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS02345	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6L01_RS02350	COG0583	DNA-binding transcription factor activity
I6L01_RS02360	COG0383	alpha-mannosidase activity
I6L01_RS02365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS02365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS02365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS02370	COG2188	Transcriptional regulator
I6L01_RS02375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L01_RS02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L01_RS02390	COG0567	Dehydrogenase, E1 component
I6L01_RS02395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L01_RS02400	COG1053	succinate dehydrogenase
I6L01_RS02405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L01_RS02410	COG2009	succinate dehydrogenase
I6L01_RS02420	COG0372	Belongs to the citrate synthase family
I6L01_RS02425	COG3539	Fimbrial protein
I6L01_RS02430	COG3188	usher protein
I6L01_RS02435	COG3121	Chaperone
I6L01_RS02440	COG3539	Fimbrial protein
I6L01_RS02445	COG3180	Ammonia monooxygenase
I6L01_RS02460	COG1984	allophanate hydrolase subunit 2
I6L01_RS02465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6L01_RS02470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L01_RS02480	COG0415	Belongs to the DNA photolyase family
I6L01_RS02485	COG3272	Protein of unknown function (DUF1722)
I6L01_RS02495	COG3209	COG3209 Rhs family protein
I6L01_RS02505	COG3209	COG3209 Rhs family protein
I6L01_RS02535	COG2205	protein histidine kinase activity
I6L01_RS02540	COG0745	RESPONSE REGULATOR receiver
I6L01_RS02550	COG1982	Orn Lys Arg decarboxylase major
I6L01_RS02555	COG0531	amino acid
I6L01_RS02560	COG0033	Phosphoglucomutase
I6L01_RS02565	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L01_RS02570	COG0596	Alpha beta hydrolase
I6L01_RS02580	COG0716	FMN binding
I6L01_RS02590	COG0735	belongs to the Fur family
I6L01_RS02615	COG1263	PTS System
I6L01_RS02615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS02615	COG2190	(PTS) system
I6L01_RS02625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L01_RS02630	COG1846	Transcriptional regulator
I6L01_RS02630	COG1940	carbohydrate kinase activity
I6L01_RS02635	COG0647	UMP catabolic process
I6L01_RS02640	COG0367	asparagine synthase
I6L01_RS02680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L01_RS02690	COG1702	phosphate starvation-inducible protein PhoH
I6L01_RS02700	COG4535	Mg2 and Co2 transporter CorC
I6L01_RS02705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L01_RS02710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS02715	COG0765	amino acid transport
I6L01_RS02720	COG0765	amino acid transport
I6L01_RS02725	COG1126	abc transporter atp-binding protein
I6L01_RS02735	COG2888	peptidyl-tyrosine sulfation
I6L01_RS02750	COG1466	dna polymerase III delta subunit
I6L01_RS02760	COG0406	alpha-ribazole phosphatase activity
I6L01_RS02765	COG0799	negative regulation of ribosome biogenesis
I6L01_RS02775	COG0768	penicillin binding
I6L01_RS02780	COG0772	Belongs to the SEDS family
I6L01_RS02785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L01_RS02790	COG1686	Belongs to the peptidase S11 family
I6L01_RS02805	COG0583	DNA-binding transcription factor activity
I6L01_RS02815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L01_RS02820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L01_RS02840	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L01_RS02845	COG4565	transcriptional regulatory protein
I6L01_RS02850	COG3290	protein histidine kinase activity
I6L01_RS02855	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6L01_RS02865	COG2301	Belongs to the HpcH HpaI aldolase family
I6L01_RS02870	COG3051	citrate lyase alpha subunit
I6L01_RS02885	COG0471	metal ion transport
I6L01_RS02890	COG3719	Belongs to the RNase T2 family
I6L01_RS02895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L01_RS02900	COG0589	response to stress
I6L01_RS02910	COG3634	alkyl hydroperoxide reductase activity
I6L01_RS02915	COG0450	alkyl hydroperoxide reductase
I6L01_RS02920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L01_RS02930	COG3969	phosphoadenosine phosphosulfate
I6L01_RS02935	COG1475	DNA binding
I6L01_RS02940	COG0436	Aminotransferase
I6L01_RS02945	COG0371	Dehydrogenase
I6L01_RS02950	COG2879	small protein
I6L01_RS02955	COG1966	Carbon starvation protein
I6L01_RS02960	COG2050	protein possibly involved in aromatic compounds catabolism
I6L01_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS02970	COG1535	isochorismatase
I6L01_RS02970	COG3433	isochorismatase activity
I6L01_RS02975	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L01_RS02980	COG1169	isochorismate synthase
I6L01_RS02985	COG4592	Periplasmic binding protein
I6L01_RS02995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS03000	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS03005	COG1120	ATPase activity
I6L01_RS03010	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L01_RS03015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L01_RS03015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L01_RS03020	COG3251	PFAM MbtH domain protein
I6L01_RS03025	COG2382	esterase
I6L01_RS03030	COG4771	TonB-dependent receptor
I6L01_RS03035	COG2977	Belongs to the P-Pant transferase superfamily
I6L01_RS03065	COG2315	Protein conserved in bacteria
I6L01_RS03070	COG0778	Nitroreductase
I6L01_RS03075	COG0668	transmembrane transport
I6L01_RS03080	COG1113	amino acid transport
I6L01_RS03085	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L01_RS03090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS03095	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS03100	COG1538	Outer membrane efflux protein
I6L01_RS03105	COG0745	RESPONSE REGULATOR receiver
I6L01_RS03110	COG5002	protein histidine kinase activity
I6L01_RS03155	COG3209	COG3209 Rhs family protein
I6L01_RS03155	COG4104	PAAR repeat-containing protein
I6L01_RS03170	COG5433	transposase activity
I6L01_RS03180	COG4783	chaperone-mediated protein folding
I6L01_RS03190	COG2207	Transcriptional regulator
I6L01_RS03200	COG2197	response regulator
I6L01_RS03205	COG3539	Fimbrial protein
I6L01_RS03210	COG3539	Fimbrial protein
I6L01_RS03215	COG3188	usher protein
I6L01_RS03220	COG3121	Chaperone
I6L01_RS03225	COG3539	Fimbrial protein
I6L01_RS03235	COG2501	S4 domain
I6L01_RS03240	COG1988	membrane-bound metal-dependent
I6L01_RS03250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L01_RS03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L01_RS03265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L01_RS03270	COG0549	Belongs to the carbamate kinase family
I6L01_RS03280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L01_RS03285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L01_RS03295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L01_RS03300	COG3257	ureidoglycine aminohydrolase activity
I6L01_RS03305	COG1929	Belongs to the glycerate kinase type-1 family
I6L01_RS03310	COG2233	PERMEase
I6L01_RS03320	COG1953	Uracil, thiamine, allantoin
I6L01_RS03325	COG2084	Dehydrogenase
I6L01_RS03330	COG3622	Belongs to the hyi family
I6L01_RS03335	COG3960	tartronate-semialdehyde synthase activity
I6L01_RS03340	COG1414	Transcriptional regulator
I6L01_RS03350	COG0583	DNA-binding transcription factor activity
I6L01_RS03375	COG3209	COG3209 Rhs family protein
I6L01_RS03380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L01_RS03385	COG4181	ATPase activity
I6L01_RS03390	COG2755	lipolytic protein G-D-S-L family
I6L01_RS03395	COG0300	oxidoreductase activity
I6L01_RS03400	COG3118	belongs to the thioredoxin family
I6L01_RS03405	COG0390	transport system, permease component
I6L01_RS03410	COG4619	ABC transporter
I6L01_RS03415	COG0330	HflC and HflK could
I6L01_RS03420	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L01_RS03440	COG0789	Transcriptional regulator
I6L01_RS03465	COG0531	amino acid
I6L01_RS03475	COG2217	Heavy metal translocating P-type atpase
I6L01_RS03480	COG3735	TraB family
I6L01_RS03485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L01_RS03490	COG0737	Belongs to the 5'-nucleotidase family
I6L01_RS03495	COG2223	nitrite transmembrane transporter activity
I6L01_RS03500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L01_RS03500	COG4651	solute:proton antiporter activity
I6L01_RS03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS03545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L01_RS03555	COG2832	Protein of unknown function (DUF454)
I6L01_RS03560	COG3923	Primosomal replication protein n
I6L01_RS03570	COG1196	nuclear chromosome segregation
I6L01_RS03570	COG3264	Mechanosensitive ion channel
I6L01_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS03585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L01_RS03600	COG0110	maltose O-acetyltransferase activity
I6L01_RS03610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6L01_RS03615	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6L01_RS03625	COG3695	enzyme binding
I6L01_RS03630	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6L01_RS03635	COG1946	Acyl-CoA thioesterase
I6L01_RS03640	COG0004	ammonium transporteR
I6L01_RS03645	COG0347	Belongs to the P(II) protein family
I6L01_RS03650	COG1132	(ABC) transporter
I6L01_RS03655	COG1132	(ABC) transporter
I6L01_RS03660	COG1522	sequence-specific DNA binding
I6L01_RS03670	COG4533	DNA binding
I6L01_RS03680	COG0824	Thioesterase
I6L01_RS03685	COG1555	photosystem II stabilization
I6L01_RS03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L01_RS03695	COG0776	regulation of translation
I6L01_RS03700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L01_RS03720	COG0271	Belongs to the BolA IbaG family
I6L01_RS03725	COG3056	Lipoprotein
I6L01_RS03730	COG2223	nitrite transmembrane transporter activity
I6L01_RS03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L01_RS03740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L01_RS03745	COG1845	cytochrome c oxidase, subunit III
I6L01_RS03750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L01_RS03760	COG2814	Major facilitator Superfamily
I6L01_RS03770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L01_RS03775	COG0693	protein deglycase activity
I6L01_RS03790	COG0142	geranyltranstransferase activity
I6L01_RS03800	COG0667	Aldo Keto reductase
I6L01_RS03810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L01_RS03815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L01_RS03830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L01_RS03830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L01_RS03845	COG0675	Transposase, IS605 OrfB family
I6L01_RS03860	COG3248	Nucleoside-binding outer membrane protein
I6L01_RS03865	COG1403	HNH endonuclease
I6L01_RS03875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L01_RS03880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L01_RS03885	COG1862	Preprotein translocase
I6L01_RS03910	COG0366	Alpha amylase catalytic
I6L01_RS03915	COG1113	amino acid transport
I6L01_RS03925	COG1114	Component of the transport system for branched-chain amino acids
I6L01_RS03930	COG5002	protein histidine kinase activity
I6L01_RS03935	COG0745	RESPONSE REGULATOR receiver
I6L01_RS03940	COG0420	3'-5' exonuclease activity
I6L01_RS03945	COG0419	ATPase involved in DNA repair
I6L01_RS03950	COG2814	Major facilitator Superfamily
I6L01_RS03960	COG1940	carbohydrate kinase activity
I6L01_RS03985	COG4126	flavin adenine dinucleotide binding
I6L01_RS04005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L01_RS04010	COG3706	GGDEF domain
I6L01_RS04020	COG1785	Belongs to the alkaline phosphatase family
I6L01_RS04035	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L01_RS04055	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L01_RS04060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L01_RS04065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L01_RS04070	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS04075	COG0113	porphobilinogen synthase activity
I6L01_RS04080	COG2175	clavaminate synthase activity
I6L01_RS04085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L01_RS04090	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L01_RS04095	COG4521	taurine ABC transporter
I6L01_RS04100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6L01_RS04105	COG1215	transferase activity, transferring glycosyl groups
I6L01_RS04135	COG3122	Protein conserved in bacteria
I6L01_RS04140	COG2814	Major facilitator Superfamily
I6L01_RS04175	COG1414	Transcriptional regulator
I6L01_RS04180	COG1609	Transcriptional regulator
I6L01_RS04190	COG2223	nitrite transmembrane transporter activity
I6L01_RS04195	COG0110	maltose O-acetyltransferase activity
I6L01_RS04200	COG2807	transmembrane transport
I6L01_RS04210	COG0288	reversible hydration of carbon dioxide
I6L01_RS04215	COG0583	DNA-binding transcription factor activity
I6L01_RS04220	COG0402	S-adenosylhomocysteine deaminase activity
I6L01_RS04225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L01_RS04230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L01_RS04235	COG2079	MmgE PrpD family protein
I6L01_RS04240	COG0372	Belongs to the citrate synthase family
I6L01_RS04245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L01_RS04250	COG3829	transcription factor binding
I6L01_RS04260	COG1280	lysine exporter protein (LysE YggA)
I6L01_RS04275	COG1064	alcohol dehydrogenase
I6L01_RS04285	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS04290	COG1129	ABC transporter
I6L01_RS04295	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS04305	COG0402	S-adenosylhomocysteine deaminase activity
I6L01_RS04310	COG0549	Belongs to the carbamate kinase family
I6L01_RS04315	COG1304	FMN binding
I6L01_RS04320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L01_RS04330	COG0666	response to abiotic stimulus
I6L01_RS04340	COG0583	DNA-binding transcription factor activity
I6L01_RS04345	COG2200	EAL domain
I6L01_RS04345	COG2771	luxR family
I6L01_RS04350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L01_RS04375	COG1556	Lactate utilization protein
I6L01_RS04380	COG1139	Iron-sulfur cluster binding protein
I6L01_RS04390	COG2207	Transcriptional regulator
I6L01_RS04395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L01_RS04405	COG3059	membrane
I6L01_RS04410	COG0656	L-ascorbic acid biosynthetic process
I6L01_RS04415	COG3708	Transcriptional regulator
I6L01_RS04415	COG2207	Transcriptional regulator
I6L01_RS04420	COG1388	LysM domain
I6L01_RS04425	COG0656	L-ascorbic acid biosynthetic process
I6L01_RS04430	COG0667	Aldo Keto reductase
I6L01_RS04440	COG0583	DNA-binding transcription factor activity
I6L01_RS04445	COG1073	alpha beta
I6L01_RS04450	COG1902	pentaerythritol trinitrate reductase activity
I6L01_RS04505	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6L01_RS04510	COG3477	response to acidic pH
I6L01_RS04515	COG2080	2 iron, 2 sulfur cluster binding
I6L01_RS04520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L01_RS04525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L01_RS04530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L01_RS04545	COG0583	DNA-binding transcription factor activity
I6L01_RS04600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L01_RS04620	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L01_RS04635	COG0454	-acetyltransferase
I6L01_RS04645	COG2161	toxin-antitoxin pair type II binding
I6L01_RS04670	COG0791	NLP P60 protein
I6L01_RS04675	COG3034	peptidoglycan biosynthetic process
I6L01_RS04680	COG0121	glutamine amidotransferase
I6L01_RS04690	COG1960	acyl-CoA dehydrogenase activity
I6L01_RS04700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L01_RS04810	COG3157	Type VI secretion system effector, Hcp
I6L01_RS04815	COG4104	PAAR repeat-containing protein
I6L01_RS04835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L01_RS04845	COG2226	methyltransferase
I6L01_RS04855	COG1388	LysM domain
I6L01_RS04855	COG0741	lytic transglycosylase activity
I6L01_RS04860	COG2226	methyltransferase
I6L01_RS04870	COG0583	DNA-binding transcription factor activity
I6L01_RS04875	COG0656	L-ascorbic acid biosynthetic process
I6L01_RS04910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L01_RS04915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L01_RS04920	COG2011	ABC-type metal ion transport system permease component
I6L01_RS04925	COG1464	Belongs to the NlpA lipoprotein family
I6L01_RS04935	COG1720	tRNA m6t6A37 methyltransferase activity
I6L01_RS04945	COG0791	NLP P60 protein
I6L01_RS04950	COG3015	lipoprotein NlpE involved in copper resistance
I6L01_RS04955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6L01_RS04960	COG4681	YaeQ
I6L01_RS04970	COG4568	rho-dependent transcription termination
I6L01_RS04975	COG0037	tRNA processing
I6L01_RS04980	COG0346	lactoylglutathione lyase activity
I6L01_RS04985	COG1982	Orn Lys Arg decarboxylase major
I6L01_RS04995	COG0587	DNA-directed DNA polymerase activity
I6L01_RS05020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L01_RS05025	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6L01_RS05035	COG0750	zinc metalloprotease
I6L01_RS05040	COG0575	Belongs to the CDS family
I6L01_RS05045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L01_RS05050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L01_RS05075	COG0024	Methionine aminopeptidase
I6L01_RS05095	COG3835	regulator
I6L01_RS05100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L01_RS05115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L01_RS05120	COG2860	membrane
I6L01_RS05145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS05150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L01_RS05155	COG1120	ATPase activity
I6L01_RS05160	COG4774	siderophore transport
I6L01_RS05165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L01_RS05170	COG1643	Atp-dependent helicase
I6L01_RS05175	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6L01_RS05185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L01_RS05190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L01_RS05195	COG0617	tRNA 3'-terminal CCA addition
I6L01_RS05200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L01_RS05205	COG3539	Fimbrial protein
I6L01_RS05210	COG3121	Chaperone
I6L01_RS05215	COG3188	usher protein
I6L01_RS05220	COG3539	Fimbrial protein
I6L01_RS05225	COG3539	Fimbrial protein
I6L01_RS05230	COG3539	Fimbrial protein
I6L01_RS05245	COG5464	transposase or invertase
I6L01_RS05255	COG0726	polysaccharide deacetylase
I6L01_RS05260	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS05265	COG0842	Transport permease protein
I6L01_RS05270	COG1131	(ABC) transporter
I6L01_RS05275	COG0288	reversible hydration of carbon dioxide
I6L01_RS05280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6L01_RS05285	COG4993	Dehydrogenase
I6L01_RS05290	COG2132	Multicopper oxidase
I6L01_RS05315	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L01_RS05320	COG3064	Membrane
I6L01_RS05325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L01_RS05330	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L01_RS05335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L01_RS05340	COG2186	Transcriptional regulator
I6L01_RS05350	COG3725	Membrane protein required for beta-lactamase induction
I6L01_RS05355	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L01_RS05360	COG0157	Belongs to the NadC ModD family
I6L01_RS05365	COG4969	Belongs to the N-Me-Phe pilin family
I6L01_RS05370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L01_RS05375	COG1459	type II secretion system
I6L01_RS05390	COG0237	dephospho-CoA kinase activity
I6L01_RS05405	COG0494	nUDIX hydrolase
I6L01_RS05425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L01_RS05430	COG0849	cell division
I6L01_RS05435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L01_RS05440	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L01_RS05455	COG0772	Belongs to the SEDS family
I6L01_RS05470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L01_RS05475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L01_RS05480	COG0768	penicillin binding
I6L01_RS05485	COG3116	cell division
I6L01_RS05500	COG1609	Transcriptional regulator
I6L01_RS05510	COG0440	acetolactate synthase activity
I6L01_RS05515	COG0028	Belongs to the TPP enzyme family
I6L01_RS05525	COG0583	DNA-binding transcription factor activity
I6L01_RS05570	COG4143	(ABC) transporter
I6L01_RS05575	COG1178	ABC-type Fe3 transport system permease component
I6L01_RS05585	COG0586	Pfam SNARE associated Golgi protein
I6L01_RS05590	COG4977	sequence-specific DNA binding
I6L01_RS05605	COG0235	Class ii aldolase
I6L01_RS05610	COG0417	DNA replication proofreading
I6L01_RS05620	COG0564	pseudouridine synthase activity
I6L01_RS05630	COG1357	PFAM Pentapeptide repeats (8 copies)
I6L01_RS05635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L01_RS05645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L01_RS05680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6L01_RS05695	COG2271	Major facilitator Superfamily
I6L01_RS05705	COG0644	oxidoreductase
I6L01_RS05755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L01_RS05760	COG0505	Belongs to the CarA family
I6L01_RS05785	COG1047	Peptidyl-prolyl cis-trans
I6L01_RS05800	COG0196	riboflavin kinase activity
I6L01_RS05825	COG3121	Chaperone
I6L01_RS05830	COG3188	usher protein
I6L01_RS05840	COG0583	DNA-binding transcription factor activity
I6L01_RS05870	COG4735	regulation of single-species biofilm formation
I6L01_RS05875	COG1584	GPR1 FUN34 yaaH family protein
I6L01_RS05880	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L01_RS05890	COG1115	amino acid carrier protein
I6L01_RS05905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L01_RS05915	COG0460	homoserine dehydrogenase
I6L01_RS05915	COG0527	aspartate kinase activity
I6L01_RS05925	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L01_RS05935	COG0745	RESPONSE REGULATOR receiver
I6L01_RS05945	COG4452	Inner membrane protein CreD
I6L01_RS05950	COG2205	protein histidine kinase activity
I6L01_RS05955	COG0745	RESPONSE REGULATOR receiver
I6L01_RS05960	COG3045	CreA protein
I6L01_RS05965	COG3708	Transcriptional regulator
I6L01_RS05965	COG2207	Transcriptional regulator
I6L01_RS05985	COG0741	lytic transglycosylase activity
I6L01_RS05990	COG0488	(ABC) transporter
I6L01_RS06000	COG0583	DNA-binding transcription factor activity
I6L01_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS06025	COG1902	pentaerythritol trinitrate reductase activity
I6L01_RS06030	COG1056	cytidyltransferase-related domain
I6L01_RS06030	COG3172	ATPase kinase involved in NAD metabolism
I6L01_RS06035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L01_RS06040	COG0560	Phosphoserine phosphatase
I6L01_RS06045	COG3726	membrane protein affecting hemolysin expression
I6L01_RS06080	COG1328	CTP reductase activity
I6L01_RS06085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L01_RS06090	COG0084	hydrolase, TatD family'
I6L01_RS06095	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L01_RS06105	COG2823	Periplasmic or secreted lipoprotein
I6L01_RS06115	COG1011	Hydrolase
I6L01_RS06120	COG0456	acetyltransferase
I6L01_RS06125	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6L01_RS06155	COG4114	ferric iron reductase
I6L01_RS06160	COG2197	response regulator
I6L01_RS06165	COG2197	response regulator
I6L01_RS06170	COG2966	Psort location CytoplasmicMembrane, score
I6L01_RS06185	COG1484	DNA-dependent DNA replication
I6L01_RS06200	COG1063	alcohol dehydrogenase
I6L01_RS06205	COG1802	Transcriptional regulator
I6L01_RS06210	COG0025	NhaP-type Na H and K H
I6L01_RS06215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6L01_RS06225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6L01_RS06230	COG0840	transmembrane signaling receptor activity
I6L01_RS06235	COG1966	Carbon starvation protein
I6L01_RS06240	COG2879	small protein
I6L01_RS06245	COG0523	cobalamin synthesis protein
I6L01_RS06250	COG1715	Restriction endonuclease
I6L01_RS06255	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6L01_RS06260	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L01_RS06265	COG0732	type I restriction modification DNA specificity domain
I6L01_RS06280	COG5457	Domain of unknown function (DUF1127)
I6L01_RS06290	COG2733	membrane
I6L01_RS06295	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6L01_RS06300	COG1924	4 iron, 4 sulfur cluster binding
I6L01_RS06315	COG0477	Major facilitator Superfamily
I6L01_RS06325	COG3366	ferrous iron transmembrane transporter activity
I6L01_RS06330	COG0700	Nucleoside recognition
I6L01_RS06335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L01_RS06340	COG0583	DNA-binding transcription factor activity
I6L01_RS06360	COG2186	Transcriptional regulator
I6L01_RS06365	COG0246	Mannitol dehydrogenase
I6L01_RS06375	COG2610	gluconate transmembrane transporter activity
I6L01_RS06380	COG3539	Fimbrial protein
I6L01_RS06385	COG3539	Fimbrial protein
I6L01_RS06390	COG3539	Fimbrial protein
I6L01_RS06395	COG3188	usher protein
I6L01_RS06400	COG3121	Chaperone
I6L01_RS06405	COG3539	Fimbrial protein
I6L01_RS06410	COG3539	Fimbrial protein
I6L01_RS06415	COG4974	Belongs to the 'phage' integrase family
I6L01_RS06420	COG0582	viral genome integration into host DNA
I6L01_RS06425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L01_RS06430	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6L01_RS06455	COG3153	acetyltransferase
I6L01_RS06460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6L01_RS06475	COG1363	Peptidase, m42
I6L01_RS06480	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L01_RS06485	COG3775	system Galactitol-specific IIC component
I6L01_RS06490	COG0434	BtpA family
I6L01_RS06495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS06500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L01_RS06505	COG1349	DNA-binding transcription factor activity
I6L01_RS06510	COG1414	Transcriptional regulator
I6L01_RS06515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L01_RS06520	COG0129	dihydroxy-acid dehydratase activity
I6L01_RS06525	COG2610	gluconate transmembrane transporter activity
I6L01_RS06530	COG2390	Transcriptional regulator
I6L01_RS06570	COG2003	Belongs to the UPF0758 family
I6L01_RS06590	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS06600	COG4983	Phage plasmid primase, P4 family domain protein
I6L01_RS06635	COG3436	PFAM IS66 Orf2 family protein
I6L01_RS06640	COG4372	Transposase
I6L01_RS06675	COG1595	DNA-templated transcription, initiation
I6L01_RS06680	COG3712	iron ion homeostasis
I6L01_RS06685	COG4772	TonB-dependent receptor
I6L01_RS06690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6L01_RS06695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS06700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS06705	COG1120	ATPase activity
I6L01_RS06710	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6L01_RS06725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L01_RS06755	COG0673	inositol 2-dehydrogenase activity
I6L01_RS06760	COG2814	Major facilitator Superfamily
I6L01_RS06765	COG3385	transposase activity
I6L01_RS06790	COG1064	alcohol dehydrogenase
I6L01_RS06795	COG3265	gluconokinase activity
I6L01_RS06800	COG1063	alcohol dehydrogenase
I6L01_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS06810	COG2610	gluconate transmembrane transporter activity
I6L01_RS06815	COG1609	Transcriptional regulator
I6L01_RS06820	COG0433	COG0433 Predicted ATPase
I6L01_RS06825	COG0795	lipopolysaccharide-transporting ATPase activity
I6L01_RS06830	COG0795	lipopolysaccharide-transporting ATPase activity
I6L01_RS06840	COG2927	DNA polymerase III (CHI subunit)
I6L01_RS06845	COG0525	valine-tRNA ligase activity
I6L01_RS06850	COG4269	membrane
I6L01_RS06855	COG0456	acetyltransferase
I6L01_RS06860	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L01_RS06875	COG2731	YhcH YjgK YiaL family protein
I6L01_RS06880	COG1309	transcriptional regulator
I6L01_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS06890	COG0251	oxidation-reduction process
I6L01_RS06910	COG0251	oxidation-reduction process
I6L01_RS06915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6L01_RS06925	COG1609	Transcriptional regulator
I6L01_RS06930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS06930	COG1263	PTS System
I6L01_RS06935	COG0366	Alpha amylase catalytic
I6L01_RS06940	COG1328	CTP reductase activity
I6L01_RS06945	COG0602	queuosine metabolic process
I6L01_RS06950	COG2026	Addiction module toxin, RelE StbE family
I6L01_RS06955	COG3077	Addiction module antitoxin, RelB DinJ family
I6L01_RS06960	COG3783	Cytochrome b(562)
I6L01_RS06965	COG0312	modulator of DNA gyrase
I6L01_RS06975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L01_RS06985	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS06990	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS06995	COG1129	ABC transporter
I6L01_RS07000	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS07005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L01_RS07010	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6L01_RS07015	COG2336	PFAM SpoVT AbrB
I6L01_RS07020	COG2105	PFAM AIG2 family protein
I6L01_RS07025	COG2911	Protein conserved in bacteria
I6L01_RS07030	COG0729	surface antigen
I6L01_RS07040	COG1253	flavin adenine dinucleotide binding
I6L01_RS07050	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L01_RS07060	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L01_RS07065	COG0737	Belongs to the 5'-nucleotidase family
I6L01_RS07070	COG1733	regulation of RNA biosynthetic process
I6L01_RS07075	COG0702	epimerase
I6L01_RS07080	COG0697	spore germination
I6L01_RS07090	COG1113	amino acid transport
I6L01_RS07095	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L01_RS07100	COG3061	Opacity-associated protein A
I6L01_RS07110	COG0675	Transposase, IS605 OrfB family
I6L01_RS07135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L01_RS07175	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L01_RS07180	COG3037	sugar-specific permease SgaT UlaA
I6L01_RS07195	COG1073	alpha beta
I6L01_RS07200	COG3650	response to hydrogen peroxide
I6L01_RS07210	COG1960	acyl-CoA dehydrogenase activity
I6L01_RS07215	COG0754	glutathionylspermidine amidase activity
I6L01_RS07220	COG5463	Belongs to the UPF0441 family
I6L01_RS07225	COG3766	membrane
I6L01_RS07235	COG1842	Phage shock protein A
I6L01_RS07240	COG3789	protein conserved in bacteria
I6L01_RS07245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L01_RS07250	COG0557	exoribonuclease II activity
I6L01_RS07265	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L01_RS07270	COG0330	HflC and HflK could
I6L01_RS07275	COG0330	HflC and HflK could
I6L01_RS07280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L01_RS07300	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L01_RS07305	COG0802	atpase or kinase
I6L01_RS07310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L01_RS07310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L01_RS07315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L01_RS07355	COG1511	domain protein
I6L01_RS07355	COG3264	Mechanosensitive ion channel
I6L01_RS07360	COG0531	amino acid
I6L01_RS07370	COG1053	succinate dehydrogenase
I6L01_RS07375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L01_RS07390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L01_RS07395	COG3040	lipid binding
I6L01_RS07400	COG2076	Multidrug Resistance protein
I6L01_RS07405	COG5510	response to toxic substance
I6L01_RS07410	COG5510	response to toxic substance
I6L01_RS07420	COG1509	lysine 2,3-aminomutase activity
I6L01_RS07445	COG0531	amino acid
I6L01_RS07450	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L01_RS07455	COG1027	Aspartate ammonia-lyase
I6L01_RS07460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L01_RS07470	COG4232	protein-disulfide reductase activity
I6L01_RS07475	COG1309	transcriptional regulator
I6L01_RS07485	COG0582	viral genome integration into host DNA
I6L01_RS07515	COG0531	amino acid
I6L01_RS07520	COG1982	Orn Lys Arg decarboxylase major
I6L01_RS07525	COG0531	amino acid
I6L01_RS07535	COG0604	alcohol dehydrogenase
I6L01_RS07590	COG4869	propanediol catabolic process
I6L01_RS07595	COG4820	ethanolamine utilization protein (EutJ)
I6L01_RS07630	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS07640	COG0693	protein deglycase activity
I6L01_RS07645	COG1882	Formate acetyltransferase
I6L01_RS07650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L01_RS07670	COG2972	Histidine kinase
I6L01_RS07675	COG2207	Transcriptional regulator
I6L01_RS07680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6L01_RS07730	COG1522	sequence-specific DNA binding
I6L01_RS07730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS07735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L01_RS07740	COG2313	pseudouridylate synthase activity
I6L01_RS07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS07750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L01_RS07770	COG3596	GTP binding
I6L01_RS07775	COG2378	regulation of single-species biofilm formation
I6L01_RS07800	COG2003	Belongs to the UPF0758 family
I6L01_RS07835	COG3710	Transcriptional regulator
I6L01_RS07840	COG0531	amino acid
I6L01_RS07845	COG1982	Orn Lys Arg decarboxylase major
I6L01_RS07850	COG3104	oligopeptide transport
I6L01_RS07855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L01_RS07870	COG2388	GCN5-related N-acetyl-transferase
I6L01_RS07875	COG3592	Divergent 4Fe-4S mono-cluster
I6L01_RS07880	COG3290	protein histidine kinase activity
I6L01_RS07885	COG4565	transcriptional regulatory protein
I6L01_RS07890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L01_RS07895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS07895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS07900	COG3647	Membrane
I6L01_RS07905	COG2211	Major facilitator Superfamily
I6L01_RS07910	COG1486	melibiose metabolic process
I6L01_RS07915	COG2169	Transcriptional regulator
I6L01_RS07920	COG1982	Orn Lys Arg decarboxylase major
I6L01_RS07925	COG2207	Transcriptional regulator
I6L01_RS07930	COG0531	amino acid
I6L01_RS07935	COG2194	sulfuric ester hydrolase activity
I6L01_RS07940	COG0745	RESPONSE REGULATOR receiver
I6L01_RS07945	COG0642	Histidine kinase
I6L01_RS07955	COG0477	Major facilitator Superfamily
I6L01_RS07965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6L01_RS07970	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L01_RS07975	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6L01_RS07985	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6L01_RS07990	COG3639	organic phosphonate transmembrane transporter activity
I6L01_RS07995	COG2188	Transcriptional regulator
I6L01_RS08000	COG3624	Phosphonate C-P lyase system protein PhnG
I6L01_RS08005	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6L01_RS08010	COG3626	phosphonate metabolism
I6L01_RS08015	COG3627	carbon phosphorus lyase activity
I6L01_RS08020	COG4107	phosphonate C-P lyase system protein PhnK
I6L01_RS08025	COG4778	phosphonate C-P lyase system protein PhnL
I6L01_RS08030	COG3454	Phosphonate metabolism
I6L01_RS08040	COG0456	acetyltransferase
I6L01_RS08045	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6L01_RS08055	COG0698	ribose 5-phosphate isomerase
I6L01_RS08060	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L01_RS08070	COG1566	PFAM secretion protein HlyD family protein
I6L01_RS08075	COG1289	transmembrane transporter activity
I6L01_RS08090	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L01_RS08095	COG1301	dicarboxylic acid transport
I6L01_RS08100	COG4235	cytochrome complex assembly
I6L01_RS08105	COG3088	subunit of a heme lyase
I6L01_RS08110	COG1138	Cytochrome C-type biogenesis protein
I6L01_RS08115	COG3301	Polysulphide reductase, NrfD
I6L01_RS08120	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS08125	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L01_RS08135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L01_RS08140	COG3162	membrane
I6L01_RS08150	COG1357	PFAM Pentapeptide repeats (8 copies)
I6L01_RS08155	COG0025	NhaP-type Na H and K H
I6L01_RS08160	COG2252	PERMEase
I6L01_RS08165	COG0789	Transcriptional regulator
I6L01_RS08170	COG2207	Transcriptional regulator
I6L01_RS08175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6L01_RS08185	COG0629	single-stranded DNA binding
I6L01_RS08190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L01_RS08195	COG2315	Protein conserved in bacteria
I6L01_RS08200	COG0432	Pfam Uncharacterised protein family UPF0047
I6L01_RS08205	COG3700	Belongs to the class B bacterial acid phosphatase family
I6L01_RS08215	COG1448	Aminotransferase
I6L01_RS08220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L01_RS08225	COG0305	Participates in initiation and elongation during chromosome replication
I6L01_RS08230	COG0604	alcohol dehydrogenase
I6L01_RS08240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L01_RS08250	COG0735	belongs to the Fur family
I6L01_RS08255	COG3237	CsbD-like
I6L01_RS08260	COG0534	Mate efflux family protein
I6L01_RS08270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L01_RS08290	COG1357	PFAM Pentapeptide repeats (8 copies)
I6L01_RS08305	COG3842	ATPase activity
I6L01_RS08310	COG2182	Extracellular solute-binding protein
I6L01_RS08315	COG1175	transmembrane transport
I6L01_RS08320	COG3833	ABC-type maltose transport systems, permease component
I6L01_RS08335	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L01_RS08360	COG0527	aspartate kinase activity
I6L01_RS08370	COG1187	pseudouridine synthase activity
I6L01_RS08420	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L01_RS08425	COG1410	methionine synthase
I6L01_RS08425	COG0646	methionine synthase
I6L01_RS08430	COG1414	Transcriptional regulator
I6L01_RS08445	COG2224	Isocitrate lyase
I6L01_RS08450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L01_RS08460	COG0456	acetyltransferase
I6L01_RS08490	COG0151	Belongs to the GarS family
I6L01_RS08495	COG2204	response regulator
I6L01_RS08500	COG4191	Histidine kinase
I6L01_RS08505	COG3678	ATP-independent chaperone mediated protein folding
I6L01_RS08520	COG3068	Protein conserved in bacteria
I6L01_RS08555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L01_RS08560	COG2104	thiamine diphosphate biosynthetic process
I6L01_RS08570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L01_RS08610	COG0250	Participates in transcription elongation, termination and antitermination
I6L01_RS08615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L01_RS08650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6L01_RS08650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6L01_RS08685	COG4206	TonB-dependent receptor
I6L01_RS08700	COG1309	transcriptional regulator
I6L01_RS08710	COG0583	DNA-binding transcription factor activity
I6L01_RS08725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L01_RS08740	COG2194	sulfuric ester hydrolase activity
I6L01_RS08745	COG2207	Transcriptional regulator
I6L01_RS08750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS08755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L01_RS08760	COG1882	Formate acetyltransferase
I6L01_RS08765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS08770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS08775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS08775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS08775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L01_RS08780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L01_RS08785	COG0371	Dehydrogenase
I6L01_RS08790	COG3738	Protein conserved in bacteria
I6L01_RS08795	COG0697	spore germination
I6L01_RS08805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L01_RS08810	COG0737	Belongs to the 5'-nucleotidase family
I6L01_RS08820	COG0460	homoserine dehydrogenase
I6L01_RS08820	COG0527	aspartate kinase activity
I6L01_RS08825	COG0626	cystathionine gamma-synthase activity
I6L01_RS08835	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6L01_RS08850	COG3209	COG3209 Rhs family protein
I6L01_RS08860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L01_RS08865	COG1609	Transcriptional regulator
I6L01_RS08870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L01_RS08885	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L01_RS08900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L01_RS08910	COG1494	fructose-1,6-bisphosphatase
I6L01_RS08920	COG0589	response to stress
I6L01_RS08925	COG3691	Protein conserved in bacteria
I6L01_RS08930	COG3152	Membrane
I6L01_RS08950	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L01_RS08965	COG3678	ATP-independent chaperone mediated protein folding
I6L01_RS08970	COG0745	RESPONSE REGULATOR receiver
I6L01_RS08975	COG2205	protein histidine kinase activity
I6L01_RS08980	COG2258	MOSC domain
I6L01_RS08990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L01_RS09035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS09040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS09040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS09045	COG1363	Peptidase, m42
I6L01_RS09050	COG3711	transcriptional antiterminator
I6L01_RS09050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS09070	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS09075	COG2864	formate dehydrogenase
I6L01_RS09085	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L01_RS09090	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L01_RS09105	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6L01_RS09110	COG0657	acetylesterase activity
I6L01_RS09125	COG0456	acetyltransferase
I6L01_RS09140	COG1011	Hydrolase
I6L01_RS09145	COG1349	DNA-binding transcription factor activity
I6L01_RS09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS09155	COG2084	Dehydrogenase
I6L01_RS09160	COG3684	Belongs to the aldolase LacD family
I6L01_RS09165	COG2942	2-epimerase
I6L01_RS09170	COG2017	converts alpha-aldose to the beta-anomer
I6L01_RS09180	COG1501	Belongs to the glycosyl hydrolase 31 family
I6L01_RS09185	COG2211	Major facilitator Superfamily
I6L01_RS09190	COG2211	Major facilitator Superfamily
I6L01_RS09195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L01_RS09200	COG2271	Major facilitator Superfamily
I6L01_RS09205	COG1082	Xylose isomerase domain protein TIM barrel
I6L01_RS09210	COG2188	Transcriptional regulator
I6L01_RS09215	COG1217	gtp-binding protein TYPA
I6L01_RS09220	COG0174	glutamine synthetase
I6L01_RS09225	COG3852	Histidine kinase
I6L01_RS09230	COG2204	response regulator
I6L01_RS09240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L01_RS09255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L01_RS09255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L01_RS09260	COG0204	Acyl-transferase
I6L01_RS09265	COG5339	Protein conserved in bacteria
I6L01_RS09275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L01_RS09280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L01_RS09285	COG3084	Protein conserved in bacteria
I6L01_RS09290	COG0746	molybdenum cofactor guanylyltransferase activity
I6L01_RS09295	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6L01_RS09330	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L01_RS09335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L01_RS09340	COG1739	Uncharacterized protein family UPF0029
I6L01_RS09360	COG0543	2 iron, 2 sulfur cluster binding
I6L01_RS09365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L01_RS09370	COG0250	Participates in transcription elongation, termination and antitermination
I6L01_RS09380	COG0805	protein transport
I6L01_RS09390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L01_RS09400	COG3165	ubiquinone biosynthetic process from chorismate
I6L01_RS09410	COG1322	Protein conserved in bacteria
I6L01_RS09415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6L01_RS09420	COG0412	Dienelactone hydrolase
I6L01_RS09425	COG3157	Type VI secretion system effector, Hcp
I6L01_RS09440	COG0583	DNA-binding transcription factor activity
I6L01_RS09445	COG0697	spore germination
I6L01_RS09450	COG0561	phosphatase activity
I6L01_RS09455	COG2267	carboxylic ester hydrolase activity
I6L01_RS09460	COG1280	lysine exporter protein (LysE YggA)
I6L01_RS09465	COG1280	lysine exporter protein (LysE YggA)
I6L01_RS09470	COG0514	ATP-dependent DNA helicase (RecQ)
I6L01_RS09475	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6L01_RS09480	COG2050	protein possibly involved in aromatic compounds catabolism
I6L01_RS09485	COG2962	Rard protein
I6L01_RS09500	COG0598	Magnesium transport protein CorA
I6L01_RS09505	COG3698	Phosphodiester glycosidase
I6L01_RS09510	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L01_RS09515	COG0210	DNA helicase
I6L01_RS09520	COG1011	Hydrolase
I6L01_RS09530	COG3159	Protein conserved in bacteria
I6L01_RS09540	COG5567	small periplasmic lipoprotein
I6L01_RS09555	COG3072	Adenylate cyclase
I6L01_RS09565	COG1587	Uroporphyrinogen-III synthase
I6L01_RS09570	COG2959	enzyme of heme biosynthesis
I6L01_RS09575	COG3071	HemY protein
I6L01_RS09580	COG3119	arylsulfatase activity
I6L01_RS09585	COG0641	radical SAM
I6L01_RS09610	COG1113	amino acid transport
I6L01_RS09630	COG2244	polysaccharide biosynthetic process
I6L01_RS09635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L01_RS09640	COG0456	acetyltransferase
I6L01_RS09645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L01_RS09650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L01_RS09655	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L01_RS09660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L01_RS09665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6L01_RS09675	COG3118	belongs to the thioredoxin family
I6L01_RS09690	COG0210	DNA helicase
I6L01_RS09695	COG3692	DNA binding
I6L01_RS09700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L01_RS09710	COG0583	DNA-binding transcription factor activity
I6L01_RS09715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L01_RS09725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L01_RS09730	COG3978	acetolactate synthase activity
I6L01_RS09750	COG0606	chelatase, subunit chli
I6L01_RS09755	COG3085	chromosome segregation
I6L01_RS09795	COG2186	Transcriptional regulator
I6L01_RS09800	COG0477	Major facilitator Superfamily
I6L01_RS09805	COG1609	Transcriptional regulator
I6L01_RS09810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS09815	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS09820	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS09825	COG1129	ABC transporter
I6L01_RS09860	COG1522	sequence-specific DNA binding
I6L01_RS09865	COG0716	FMN binding
I6L01_RS09880	COG3312	ion transport
I6L01_RS09935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L01_RS09940	COG0573	inorganic phosphate transmembrane transporter activity
I6L01_RS09945	COG0581	inorganic phosphate transmembrane transporter activity
I6L01_RS09950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L01_RS09955	COG0704	Plays a role in the regulation of phosphate uptake
I6L01_RS09985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L01_RS09990	COG2252	PERMEase
I6L01_RS09995	COG0431	NADPH-dependent FMN reductase
I6L01_RS10000	COG2091	lysine biosynthetic process via aminoadipic acid
I6L01_RS10015	COG0814	amino acid
I6L01_RS10070	COG0592	DNA-directed DNA polymerase activity
I6L01_RS10080	COG0187	DNA topoisomerase II activity
I6L01_RS10085	COG3753	Protein conserved in bacteria
I6L01_RS10090	COG0561	phosphatase activity
I6L01_RS10100	COG2186	Transcriptional regulator
I6L01_RS10105	COG3734	2-keto-3-deoxy-galactonokinase
I6L01_RS10110	COG0800	Aldolase
I6L01_RS10120	COG2271	Major facilitator Superfamily
I6L01_RS10125	COG0644	oxidoreductase
I6L01_RS10130	COG0823	Involved in the tonB-independent uptake of proteins
I6L01_RS10135	COG5645	(Lipo)protein
I6L01_RS10155	COG2188	Transcriptional regulator
I6L01_RS10170	COG2207	Transcriptional regulator
I6L01_RS10175	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L01_RS10180	COG3119	arylsulfatase activity
I6L01_RS10185	COG2149	membrane
I6L01_RS10195	COG0641	radical SAM
I6L01_RS10200	COG2814	Major facilitator Superfamily
I6L01_RS10215	COG0028	Belongs to the TPP enzyme family
I6L01_RS10220	COG0440	acetolactate synthase activity
I6L01_RS10235	COG2197	response regulator
I6L01_RS10240	COG3851	Histidine kinase
I6L01_RS10245	COG2271	Major facilitator Superfamily
I6L01_RS10250	COG2271	Major facilitator Superfamily
I6L01_RS10260	COG2252	PERMEase
I6L01_RS10285	COG1388	LysM domain
I6L01_RS10285	COG2373	Large extracellular alpha-helical protein
I6L01_RS10285	COG4932	domain protein
I6L01_RS10310	COG0457	Tetratricopeptide repeat
I6L01_RS10320	COG1464	Belongs to the NlpA lipoprotein family
I6L01_RS10325	COG0697	spore germination
I6L01_RS10330	COG2814	Major facilitator Superfamily
I6L01_RS10345	COG2271	Major facilitator Superfamily
I6L01_RS10350	COG1609	Transcriptional regulator
I6L01_RS10360	COG0582	viral genome integration into host DNA
I6L01_RS10370	COG2211	Major facilitator Superfamily
I6L01_RS10375	COG1501	Belongs to the glycosyl hydrolase 31 family
I6L01_RS10380	COG3711	transcriptional antiterminator
I6L01_RS10385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS10385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS10385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS10390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS10395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS10395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS10410	COG1940	carbohydrate kinase activity
I6L01_RS10420	COG2982	Protein involved in outer membrane biogenesis
I6L01_RS10425	COG2233	PERMEase
I6L01_RS10430	COG0786	glutamate:sodium symporter activity
I6L01_RS10435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L01_RS10440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L01_RS10445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L01_RS10455	COG0194	GDP metabolic process
I6L01_RS10465	COG2860	membrane
I6L01_RS10470	COG3645	SOS response
I6L01_RS10475	COG1561	YicC-like family, N-terminal region
I6L01_RS10500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L01_RS10520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L01_RS10530	COG1519	Transferase
I6L01_RS10535	COG0859	PFAM glycosyl transferase family 9
I6L01_RS10540	COG0438	transferase activity, transferring glycosyl groups
I6L01_RS10545	COG0515	serine threonine protein kinase
I6L01_RS10560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L01_RS10565	COG1442	glycosyl transferase family 8
I6L01_RS10580	COG0859	PFAM glycosyl transferase family 9
I6L01_RS10585	COG0859	PFAM glycosyl transferase family 9
I6L01_RS10595	COG0156	8-amino-7-oxononanoate synthase activity
I6L01_RS10605	COG1216	Glycosyl transferase, family 2
I6L01_RS10610	COG2861	carbohydrate metabolic process
I6L01_RS10615	COG4942	peptidase
I6L01_RS10625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L01_RS10630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L01_RS10645	COG1045	serine acetyltransferase
I6L01_RS10650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L01_RS10660	COG2186	Transcriptional regulator
I6L01_RS10665	COG1620	l-lactate permease
I6L01_RS10670	COG5295	Hep Hag repeat protein
I6L01_RS10690	COG3722	fumarate hydratase activity
I6L01_RS10700	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS10700	COG2213	PTS system mannitol-specific
I6L01_RS10710	COG1566	PFAM secretion protein HlyD family protein
I6L01_RS10715	COG0625	glutathione transferase activity
I6L01_RS10725	COG3276	selenocysteine insertion sequence binding
I6L01_RS10730	COG1454	alcohol dehydrogenase
I6L01_RS10740	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS10755	COG1566	PFAM secretion protein HlyD family protein
I6L01_RS10760	COG0583	DNA-binding transcription factor activity
I6L01_RS10765	COG3713	MltA-interacting MipA family protein
I6L01_RS10775	COG2211	Major facilitator Superfamily
I6L01_RS10785	COG0235	Class ii aldolase
I6L01_RS10790	COG3623	hexulose-6-phosphate isomerase
I6L01_RS10795	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6L01_RS10800	COG1070	Carbohydrate kinase
I6L01_RS10805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6L01_RS10810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6L01_RS10815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6L01_RS10820	COG2731	YhcH YjgK YiaL family protein
I6L01_RS10830	COG1414	Transcriptional regulator
I6L01_RS10835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS10840	COG3977	Valine--pyruvate aminotransferase
I6L01_RS10845	COG0366	Alpha amylase catalytic
I6L01_RS10850	COG2992	FlgJ-related protein
I6L01_RS10860	COG4214	carbohydrate transport
I6L01_RS10870	COG4213	ABC transporter substrate-binding protein
I6L01_RS10880	COG1070	Carbohydrate kinase
I6L01_RS10885	COG4682	membrane
I6L01_RS10890	COG4682	membrane
I6L01_RS10895	COG3274	enterobacterial common antigen metabolic process
I6L01_RS10930	COG1278	Cold shock
I6L01_RS10935	COG2944	sequence-specific DNA binding
I6L01_RS10950	COG2885	chlorophyll binding
I6L01_RS10955	COG0243	molybdopterin cofactor binding
I6L01_RS10960	COG0456	acetyltransferase
I6L01_RS10965	COG2818	Glycosylase
I6L01_RS10970	COG5571	outer membrane autotransporter
I6L01_RS10975	COG2223	nitrite transmembrane transporter activity
I6L01_RS10980	COG2194	sulfuric ester hydrolase activity
I6L01_RS10995	COG0747	negative chemotaxis
I6L01_RS11000	COG0601	transmembrane transport
I6L01_RS11005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L01_RS11010	COG0444	Belongs to the ABC transporter superfamily
I6L01_RS11015	COG4608	Belongs to the ABC transporter superfamily
I6L01_RS11020	COG0814	amino acid
I6L01_RS11040	COG2194	sulfuric ester hydrolase activity
I6L01_RS11070	COG1215	transferase activity, transferring glycosyl groups
I6L01_RS11075	COG1215	transferase activity, transferring glycosyl groups
I6L01_RS11080	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6L01_RS11085	COG3118	belongs to the thioredoxin family
I6L01_RS11085	COG0457	Tetratricopeptide repeat
I6L01_RS11090	COG2199	diguanylate cyclase activity
I6L01_RS11090	COG2200	EAL domain
I6L01_RS11100	COG0612	Peptidase, M16
I6L01_RS11110	COG2200	EAL domain
I6L01_RS11115	COG2982	Protein involved in outer membrane biogenesis
I6L01_RS11120	COG0477	Major facilitator Superfamily
I6L01_RS11125	COG1295	ribonuclease BN
I6L01_RS11130	COG0583	DNA-binding transcription factor activity
I6L01_RS11135	COG2197	response regulator
I6L01_RS11145	COG1858	cytochrome C peroxidase
I6L01_RS11150	COG0076	glutamate decarboxylase activity
I6L01_RS11160	COG2207	Transcriptional regulator
I6L01_RS11165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L01_RS11170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS11180	COG2771	luxR family
I6L01_RS11185	COG3247	response to pH
I6L01_RS11200	COG1285	pathogenesis
I6L01_RS11210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS11220	COG3721	Heme iron utilization protein
I6L01_RS11230	COG4558	Periplasmic binding protein
I6L01_RS11235	COG4771	TonB-dependent receptor
I6L01_RS11240	COG3720	iron ion transport
I6L01_RS11245	COG2197	response regulator
I6L01_RS11250	COG3065	identical protein binding
I6L01_RS11270	COG1393	Belongs to the ArsC family
I6L01_RS11275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6L01_RS11280	COG0640	Transcriptional regulator
I6L01_RS11290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L01_RS11295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L01_RS11300	COG0339	signal peptide processing
I6L01_RS11310	COG3104	oligopeptide transport
I6L01_RS11315	COG0589	response to stress
I6L01_RS11325	COG0306	phosphate transporter
I6L01_RS11330	COG2081	HI0933 family
I6L01_RS11350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS11355	COG0842	Transport permease protein
I6L01_RS11355	COG1129	ABC transporter
I6L01_RS11360	COG0842	Transport permease protein
I6L01_RS11380	COG1413	lyase activity
I6L01_RS11390	COG3209	COG3209 Rhs family protein
I6L01_RS11410	COG3209	COG3209 Rhs family protein
I6L01_RS11430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L01_RS11435	COG0601	transmembrane transport
I6L01_RS11440	COG0747	negative chemotaxis
I6L01_RS11445	COG2091	lysine biosynthetic process via aminoadipic acid
I6L01_RS11450	COG0628	permease
I6L01_RS11465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L01_RS11480	COG3714	YhhN family
I6L01_RS11490	COG3776	membrane
I6L01_RS11495	COG0742	ribosomal rna small subunit methyltransferase
I6L01_RS11500	COG0552	protein localization to endoplasmic reticulum
I6L01_RS11505	COG2884	Cell division ATP-binding protein ftsE
I6L01_RS11510	COG2177	Part of the ABC transporter FtsEX involved in
I6L01_RS11515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L01_RS11520	COG0683	leucine binding
I6L01_RS11525	COG0456	acetyltransferase
I6L01_RS11530	COG0683	leucine binding
I6L01_RS11535	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS11540	COG4177	L-phenylalanine transmembrane transporter activity
I6L01_RS11545	COG0411	ABC transporter
I6L01_RS11550	COG0410	ABC transporter
I6L01_RS11555	COG1653	transport
I6L01_RS11560	COG1175	transmembrane transport
I6L01_RS11575	COG0584	glycerophosphoryl diester phosphodiesterase
I6L01_RS11585	COG0405	Gamma-glutamyltransferase
I6L01_RS11605	COG3157	Type VI secretion system effector, Hcp
I6L01_RS11610	COG1247	-acetyltransferase
I6L01_RS11615	COG0673	inositol 2-dehydrogenase activity
I6L01_RS11620	COG1741	Belongs to the pirin family
I6L01_RS11625	COG1609	Transcriptional regulator
I6L01_RS11630	COG3265	gluconokinase activity
I6L01_RS11635	COG2610	gluconate transmembrane transporter activity
I6L01_RS11640	COG2095	MarC family integral membrane protein
I6L01_RS11645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L01_RS11650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L01_RS11670	COG0058	SHG alpha-glucan phosphorylase activity
I6L01_RS11690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L01_RS11705	COG1349	DNA-binding transcription factor activity
I6L01_RS11710	COG4650	regulator
I6L01_RS11715	COG1690	Belongs to the RtcB family
I6L01_RS11730	COG0058	SHG alpha-glucan phosphorylase activity
I6L01_RS11735	COG1640	4-alpha-glucanotransferase
I6L01_RS11740	COG2610	gluconate transmembrane transporter activity
I6L01_RS11750	COG1040	competence protein
I6L01_RS11760	COG5464	transposase or invertase
I6L01_RS11770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6L01_RS11775	COG1918	ferrous iron import across plasma membrane
I6L01_RS11780	COG2183	response to ionizing radiation
I6L01_RS11785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L01_RS11815	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6L01_RS11825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L01_RS11830	COG1011	Hydrolase
I6L01_RS11840	COG0494	nUDIX hydrolase
I6L01_RS11845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L01_RS11850	COG4972	Pilus assembly protein
I6L01_RS11855	COG3166	PFAM Fimbrial assembly family protein
I6L01_RS11870	COG4796	Type ii and iii secretion system protein
I6L01_RS11885	COG3266	domain, Protein
I6L01_RS11890	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L01_RS11895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L01_RS11900	COG0546	phosphoglycolate phosphatase activity
I6L01_RS11905	COG0180	Tryptophanyl-tRNA synthetase
I6L01_RS11910	COG2188	Transcriptional regulator
I6L01_RS11920	COG3457	Alanine racemase
I6L01_RS11925	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L01_RS11930	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6L01_RS11945	COG0626	cystathionine gamma-synthase activity
I6L01_RS11960	COG2116	formate transmembrane transporter activity
I6L01_RS11965	COG2146	nitrite reductase [NAD(P)H] activity
I6L01_RS11970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L01_RS11980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L01_RS11990	COG2184	nucleotidyltransferase activity
I6L01_RS11995	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L01_RS12000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L01_RS12005	COG1289	transmembrane transporter activity
I6L01_RS12010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L01_RS12015	COG1765	OsmC-like protein
I6L01_RS12020	COG3954	Phosphoribulokinase
I6L01_RS12030	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L01_RS12035	COG0488	(ABC) transporter
I6L01_RS12050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L01_RS12055	COG1047	Peptidyl-prolyl cis-trans
I6L01_RS12065	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L01_RS12070	COG2964	Protein conserved in bacteria
I6L01_RS12140	COG0089	rRNA binding
I6L01_RS12230	COG0201	protein transport
I6L01_RS12270	COG0789	Transcriptional regulator
I6L01_RS12275	COG3036	rescue of stalled ribosome
I6L01_RS12285	COG0569	domain protein
I6L01_RS12305	COG0758	DNA mediated transformation
I6L01_RS12315	COG0551	DNA topoisomerase type I activity
I6L01_RS12335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L01_RS12375	COG1126	abc transporter atp-binding protein
I6L01_RS12380	COG0765	amino acid transport
I6L01_RS12385	COG4597	amino acid ABC transporter
I6L01_RS12390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS12400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L01_RS12405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS12410	COG1309	transcriptional regulator
I6L01_RS12420	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6L01_RS12430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L01_RS12440	COG4145	pantothenate transmembrane transporter activity
I6L01_RS12445	COG3924	membrane
I6L01_RS12450	COG0439	Biotin carboxylase
I6L01_RS12455	COG0511	ligase activity, forming carbon-carbon bonds
I6L01_RS12460	COG0604	alcohol dehydrogenase
I6L01_RS12465	COG2199	diguanylate cyclase activity
I6L01_RS12465	COG2200	EAL domain
I6L01_RS12470	COG1077	Cell shape determining protein MreB Mrl
I6L01_RS12475	COG1792	Involved in formation and maintenance of cell shape
I6L01_RS12480	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L01_RS12490	COG1530	ribonuclease E activity
I6L01_RS12495	COG3164	Protein of unknown function
I6L01_RS12500	COG0312	modulator of DNA gyrase
I6L01_RS12525	COG2732	(Barnase) inhibitor
I6L01_RS12545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L01_RS12550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L01_RS12555	COG3105	Protein conserved in bacteria
I6L01_RS12560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L01_RS12575	COG0625	glutathione transferase activity
I6L01_RS12580	COG2969	positive regulation of protein catabolic process
I6L01_RS12585	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L01_RS12615	COG2731	YhcH YjgK YiaL family protein
I6L01_RS12620	COG4804	nuclease activity
I6L01_RS12625	COG0493	'glutamate synthase
I6L01_RS12630	COG0070	glutamate synthase
I6L01_RS12630	COG0069	glutamate synthase activity
I6L01_RS12630	COG0067	glutamate synthase
I6L01_RS12635	COG1242	4 iron, 4 sulfur cluster binding
I6L01_RS12640	COG2198	Histidine kinase
I6L01_RS12640	COG0784	Response regulator, receiver
I6L01_RS12640	COG5002	protein histidine kinase activity
I6L01_RS12645	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L01_RS12655	COG0515	serine threonine protein kinase
I6L01_RS12660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS12675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L01_RS12680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L01_RS12685	COG1137	ATPase activity
I6L01_RS12690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L01_RS12695	COG3117	lipopolysaccharide transmembrane transporter activity
I6L01_RS12700	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L01_RS12705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L01_RS12705	COG0517	IMP dehydrogenase activity
I6L01_RS12710	COG0530	calcium, potassium:sodium antiporter activity
I6L01_RS12715	COG1127	ABC transporter
I6L01_RS12720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L01_RS12725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L01_RS12730	COG2854	intermembrane phospholipid transfer
I6L01_RS12735	COG3113	response to antibiotic
I6L01_RS12740	COG5007	Belongs to the BolA IbaG family
I6L01_RS12750	COG3423	Transcriptional regulator
I6L01_RS12755	COG0142	geranyltranstransferase activity
I6L01_RS12770	COG0697	spore germination
I6L01_RS12780	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L01_RS12785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L01_RS12790	COG1534	Rna-binding protein
I6L01_RS12800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L01_RS12805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L01_RS12815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L01_RS12825	COG2194	sulfuric ester hydrolase activity
I6L01_RS12845	COG0195	Participates in both transcription termination and antitermination
I6L01_RS12885	COG0513	Belongs to the DEAD box helicase family
I6L01_RS12890	COG0814	amino acid
I6L01_RS12895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L01_RS12900	COG0826	peptidase U32
I6L01_RS12905	COG0826	peptidase U32
I6L01_RS12910	COG3154	lipid carrier protein
I6L01_RS12915	COG3153	acetyltransferase
I6L01_RS12930	COG0693	protein deglycase activity
I6L01_RS12935	COG0702	epimerase
I6L01_RS12940	COG0701	Predicted permease
I6L01_RS12945	COG2823	Periplasmic or secreted lipoprotein
I6L01_RS12965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L01_RS12970	COG0363	glucosamine-6-phosphate deaminase activity
I6L01_RS12975	COG3716	PTS system mannose fructose sorbose family IID component
I6L01_RS12980	COG3715	PTS system
I6L01_RS12985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS12995	COG2222	sugar isomerase
I6L01_RS13000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L01_RS13005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS13010	COG3716	PTS system mannose fructose sorbose family IID component
I6L01_RS13020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS13030	COG1349	DNA-binding transcription factor activity
I6L01_RS13040	COG2002	toxin-antitoxin pair type II binding
I6L01_RS13045	COG2721	sulfolactate sulfo-lyase activity
I6L01_RS13050	COG2271	Major facilitator Superfamily
I6L01_RS13060	COG2084	Dehydrogenase
I6L01_RS13065	COG1929	Belongs to the glycerate kinase type-1 family
I6L01_RS13090	COG0583	DNA-binding transcription factor activity
I6L01_RS13095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L01_RS13105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L01_RS13110	COG1882	Formate acetyltransferase
I6L01_RS13115	COG0251	oxidation-reduction process
I6L01_RS13120	COG1760	l-serine dehydratase
I6L01_RS13125	COG0814	amino acid
I6L01_RS13140	COG1741	Belongs to the pirin family
I6L01_RS13145	COG0583	DNA-binding transcription factor activity
I6L01_RS13150	COG3152	Membrane
I6L01_RS13155	COG3152	Membrane
I6L01_RS13160	COG0435	Glutathione S-transferase
I6L01_RS13165	COG2259	Doxx family
I6L01_RS13175	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6L01_RS13180	COG4575	ribosome binding
I6L01_RS13185	COG1422	Protein of unknown function (DUF1090)
I6L01_RS13195	COG0586	Pfam SNARE associated Golgi protein
I6L01_RS13200	COG2186	Transcriptional regulator
I6L01_RS13205	COG2271	Major facilitator Superfamily
I6L01_RS13215	COG2721	sulfolactate sulfo-lyase activity
I6L01_RS13225	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L01_RS13230	COG0861	Integral membrane protein TerC family
I6L01_RS13235	COG0673	inositol 2-dehydrogenase activity
I6L01_RS13240	COG2949	membrane
I6L01_RS13245	COG1451	nucleotide metabolic process
I6L01_RS13255	COG1902	pentaerythritol trinitrate reductase activity
I6L01_RS13255	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L01_RS13260	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L01_RS13260	COG3408	Glycogen debranching enzyme
I6L01_RS13270	COG0531	amino acid
I6L01_RS13275	COG2731	YhcH YjgK YiaL family protein
I6L01_RS13280	COG3250	beta-galactosidase activity
I6L01_RS13285	COG1609	Transcriptional regulator
I6L01_RS13290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L01_RS13300	COG0840	transmembrane signaling receptor activity
I6L01_RS13305	COG1695	Transcriptional regulator
I6L01_RS13310	COG2375	cellular response to nickel ion
I6L01_RS13325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L01_RS13330	COG0358	DNA primase activity
I6L01_RS13335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L01_RS13350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS13355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS13370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L01_RS13385	COG4991	sh3 domain protein
I6L01_RS13390	COG3025	triphosphatase activity
I6L01_RS13415	COG2268	Band 7 protein
I6L01_RS13420	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L01_RS13430	COG3539	Fimbrial protein
I6L01_RS13435	COG3121	Chaperone
I6L01_RS13440	COG3188	usher protein
I6L01_RS13445	COG3539	Fimbrial protein
I6L01_RS13450	COG2960	long-chain fatty acid transporting porin activity
I6L01_RS13470	COG3384	dioxygenase
I6L01_RS13475	COG0754	glutathionylspermidine amidase activity
I6L01_RS13485	COG1538	Outer membrane efflux protein
I6L01_RS13490	COG0494	nUDIX hydrolase
I6L01_RS13495	COG3151	Protein conserved in bacteria
I6L01_RS13500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L01_RS13505	COG3150	esterase
I6L01_RS13510	COG0187	DNA topoisomerase II activity
I6L01_RS13515	COG4774	siderophore transport
I6L01_RS13520	COG1120	ATPase activity
I6L01_RS13525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS13530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS13540	COG1737	Transcriptional regulator
I6L01_RS13545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L01_RS13550	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L01_RS13555	COG0642	Histidine kinase
I6L01_RS13560	COG0745	RESPONSE REGULATOR receiver
I6L01_RS13565	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L01_RS13570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6L01_RS13575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6L01_RS13580	COG0204	Acyl-transferase
I6L01_RS13585	COG2132	Multicopper oxidase
I6L01_RS13590	COG1032	radical SAM domain protein
I6L01_RS13595	COG4238	major outer membrane lipoprotein
I6L01_RS13605	COG0656	L-ascorbic acid biosynthetic process
I6L01_RS13610	COG1979	alcohol dehydrogenase
I6L01_RS13615	COG2207	Transcriptional regulator
I6L01_RS13620	COG0586	Pfam SNARE associated Golgi protein
I6L01_RS13625	COG0626	cystathionine gamma-synthase activity
I6L01_RS13630	COG0811	peptide transport
I6L01_RS13635	COG0848	biopolymer transport protein
I6L01_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS13650	COG0667	Aldo Keto reductase
I6L01_RS13665	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L01_RS13670	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS13675	COG5557	Pfam Polysulphide reductase, NrfD
I6L01_RS13680	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L01_RS13685	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L01_RS13690	COG1773	rubredoxin
I6L01_RS13700	COG0298	carbon dioxide binding
I6L01_RS13705	COG0625	glutathione transferase activity
I6L01_RS13710	COG0754	glutathionylspermidine amidase activity
I6L01_RS13715	COG0306	phosphate transporter
I6L01_RS13720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L01_RS13725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L01_RS13730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L01_RS13735	COG2244	polysaccharide biosynthetic process
I6L01_RS13745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L01_RS13750	COG0795	lipopolysaccharide-transporting ATPase activity
I6L01_RS13760	COG0156	8-amino-7-oxononanoate synthase activity
I6L01_RS13765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L01_RS13770	COG0318	PFAM AMP-dependent synthetase and ligase
I6L01_RS13775	COG0456	acetyltransferase
I6L01_RS13780	COG2186	Transcriptional regulator
I6L01_RS13785	COG0277	FAD linked oxidase domain protein
I6L01_RS13790	COG0277	FAD linked oxidase domain protein
I6L01_RS13795	COG0247	lactate metabolic process
I6L01_RS13800	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6L01_RS13810	COG1620	l-lactate permease
I6L01_RS13815	COG3064	Membrane
I6L01_RS13820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6L01_RS13840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L01_RS13845	COG1459	type II secretion system
I6L01_RS13850	COG2165	general secretion pathway protein
I6L01_RS13880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L01_RS13895	COG1215	transferase activity, transferring glycosyl groups
I6L01_RS13895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6L01_RS14010	COG2003	Belongs to the UPF0758 family
I6L01_RS14035	COG2020	methyltransferase activity
I6L01_RS14040	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS14050	COG4983	Phage plasmid primase, P4 family domain protein
I6L01_RS14090	COG3436	PFAM IS66 Orf2 family protein
I6L01_RS14110	COG0582	viral genome integration into host DNA
I6L01_RS14120	COG1811	Na channel or pump
I6L01_RS14125	COG1982	Orn Lys Arg decarboxylase major
I6L01_RS14130	COG2211	Major facilitator Superfamily
I6L01_RS14145	COG1194	a g-specific adenine glycosylase
I6L01_RS14155	COG3171	Protein conserved in bacteria
I6L01_RS14165	COG0252	asparaginase activity
I6L01_RS14180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6L01_RS14185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6L01_RS14190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L01_RS14195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L01_RS14205	COG0762	integral membrane protein
I6L01_RS14210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L01_RS14215	COG2805	Type II/IV secretion system protein
I6L01_RS14230	COG0189	ligase activity
I6L01_RS14235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L01_RS14240	COG2356	endonuclease I
I6L01_RS14250	COG2814	Major facilitator Superfamily
I6L01_RS14270	COG1166	arginine decarboxylase activity
I6L01_RS14280	COG0501	Belongs to the peptidase M48B family
I6L01_RS14285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L01_RS14290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS14295	COG2213	PTS system mannitol-specific
I6L01_RS14300	COG1063	alcohol dehydrogenase
I6L01_RS14305	COG1494	fructose-1,6-bisphosphatase
I6L01_RS14310	COG3722	fumarate hydratase activity
I6L01_RS14315	COG1072	(Pantothenic acid kinase))
I6L01_RS14330	COG0191	fructose-bisphosphate aldolase activity
I6L01_RS14335	COG0668	transmembrane transport
I6L01_RS14340	COG1279	arginine transmembrane transporter activity
I6L01_RS14345	COG2968	Membrane
I6L01_RS14350	COG0583	DNA-binding transcription factor activity
I6L01_RS14355	COG0427	acetyl-CoA hydrolase
I6L01_RS14360	COG1024	Enoyl-CoA hydratase
I6L01_RS14365	COG1703	isobutyryl-CoA mutase activity
I6L01_RS14370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6L01_RS14370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6L01_RS14390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L01_RS14400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L01_RS14420	COG0006	proline dipeptidase activity
I6L01_RS14425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L01_RS14430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L01_RS14455	COG2723	6-phospho-beta-galactosidase activity
I6L01_RS14465	COG1272	protein, Hemolysin III
I6L01_RS14475	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L01_RS14485	COG0716	FMN binding
I6L01_RS14490	COG4974	Belongs to the 'phage' integrase family
I6L01_RS14495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L01_RS14500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L01_RS14510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L01_RS14530	COG2233	PERMEase
I6L01_RS14535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS14535	COG0493	'glutamate synthase
I6L01_RS14540	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS14545	COG2252	PERMEase
I6L01_RS14550	COG0402	S-adenosylhomocysteine deaminase activity
I6L01_RS14555	COG2233	PERMEase
I6L01_RS14560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L01_RS14560	COG2080	2 iron, 2 sulfur cluster binding
I6L01_RS14565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L01_RS14570	COG0402	S-adenosylhomocysteine deaminase activity
I6L01_RS14575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS14575	COG0493	'glutamate synthase
I6L01_RS14580	COG2068	MobA-Related Protein
I6L01_RS14585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L01_RS14590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L01_RS14590	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L01_RS14595	COG0549	Belongs to the carbamate kinase family
I6L01_RS14605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L01_RS14610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L01_RS14615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L01_RS14620	COG3829	transcription factor binding
I6L01_RS14625	COG2080	2 iron, 2 sulfur cluster binding
I6L01_RS14630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L01_RS14635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L01_RS14640	COG4942	peptidase
I6L01_RS14650	COG3387	PFAM Glycoside hydrolase 15-related
I6L01_RS14660	COG2207	Transcriptional regulator
I6L01_RS14760	COG2197	response regulator
I6L01_RS14765	COG0741	lytic transglycosylase activity
I6L01_RS14775	COG0457	Tetratricopeptide repeat
I6L01_RS14775	COG3710	Transcriptional regulator
I6L01_RS14780	COG0457	Tetratricopeptide repeat
I6L01_RS14805	COG3710	Transcriptional regulator
I6L01_RS14810	COG2771	luxR family
I6L01_RS14815	COG0814	amino acid
I6L01_RS14820	COG0183	Belongs to the thiolase family
I6L01_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS14835	COG2814	Major facilitator Superfamily
I6L01_RS14840	COG1794	racemase activity, acting on amino acids and derivatives
I6L01_RS14845	COG0583	DNA-binding transcription factor activity
I6L01_RS14855	COG1609	Transcriptional regulator
I6L01_RS14870	COG0667	Aldo Keto reductase
I6L01_RS14880	COG0861	Integral membrane protein TerC family
I6L01_RS14895	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6L01_RS14910	COG2165	general secretion pathway protein
I6L01_RS14915	COG4795	General secretion pathway protein
I6L01_RS14925	COG4967	type IV pilus modification protein PilV
I6L01_RS14930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L01_RS14940	COG1074	ATP-dependent DNA helicase activity
I6L01_RS14945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L01_RS14950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L01_RS14950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L01_RS14955	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L01_RS14960	COG3711	transcriptional antiterminator
I6L01_RS14965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS14965	COG1263	PTS System
I6L01_RS14970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L01_RS15000	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L01_RS15005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L01_RS15010	COG2166	iron-sulfur cluster assembly
I6L01_RS15015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L01_RS15025	COG0583	DNA-binding transcription factor activity
I6L01_RS15030	COG2363	Small membrane protein
I6L01_RS15040	COG1349	DNA-binding transcription factor activity
I6L01_RS15050	COG1070	Carbohydrate kinase
I6L01_RS15060	COG1129	ABC transporter
I6L01_RS15065	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS15070	COG1609	Transcriptional regulator
I6L01_RS15075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L01_RS15085	COG0235	Class ii aldolase
I6L01_RS15090	COG1454	alcohol dehydrogenase
I6L01_RS15100	COG1760	l-serine dehydratase
I6L01_RS15105	COG0814	amino acid
I6L01_RS15110	COG1611	Belongs to the LOG family
I6L01_RS15125	COG3098	single-species biofilm formation
I6L01_RS15130	COG0564	pseudouridine synthase activity
I6L01_RS15135	COG0716	FMN binding
I6L01_RS15140	COG2271	Major facilitator Superfamily
I6L01_RS15145	COG4948	Mandelate Racemase Muconate Lactonizing
I6L01_RS15150	COG4948	Mandelate Racemase Muconate Lactonizing
I6L01_RS15155	COG4999	Histidine kinase
I6L01_RS15155	COG2205	protein histidine kinase activity
I6L01_RS15155	COG3437	response regulator, receiver
I6L01_RS15155	COG3850	Histidine kinase
I6L01_RS15165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L01_RS15170	COG2336	PFAM SpoVT AbrB
I6L01_RS15175	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6L01_RS15180	COG3956	TIGRFAM MazG family protein
I6L01_RS15200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L01_RS15210	COG0602	queuosine metabolic process
I6L01_RS15215	COG1070	Carbohydrate kinase
I6L01_RS15220	COG2223	nitrite transmembrane transporter activity
I6L01_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS15230	COG0277	FAD linked oxidase domain protein
I6L01_RS15235	COG0477	Major facilitator Superfamily
I6L01_RS15240	COG2086	electron transfer activity
I6L01_RS15245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6L01_RS15255	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6L01_RS15260	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L01_RS15265	COG0644	oxidoreductase
I6L01_RS15270	COG0720	synthase
I6L01_RS15295	COG1203	CRISPR-associated helicase, Cas3
I6L01_RS15310	COG1857	crispr-associated protein
I6L01_RS15325	COG1518	maintenance of DNA repeat elements
I6L01_RS15330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L01_RS15340	COG2234	aminopeptidase activity
I6L01_RS15395	COG1388	LysM domain
I6L01_RS15395	COG4942	peptidase
I6L01_RS15410	COG0163	prenyltransferase activity
I6L01_RS15415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L01_RS15425	COG2610	gluconate transmembrane transporter activity
I6L01_RS15430	COG3622	Belongs to the hyi family
I6L01_RS15435	COG0235	Class ii aldolase
I6L01_RS15440	COG3395	kinase activity
I6L01_RS15445	COG2084	Dehydrogenase
I6L01_RS15450	COG1349	DNA-binding transcription factor activity
I6L01_RS15455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L01_RS15485	COG0309	Hydrogenase expression formation protein (HypE)
I6L01_RS15490	COG0409	Hydrogenase expression formation protein
I6L01_RS15495	COG0298	carbon dioxide binding
I6L01_RS15500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L01_RS15505	COG0375	protein maturation
I6L01_RS15515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS15520	COG0651	ATP synthesis coupled electron transport
I6L01_RS15525	COG0650	Formate hydrogenlyase subunit 4
I6L01_RS15530	COG3261	NADH dehydrogenase
I6L01_RS15530	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L01_RS15535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L01_RS15540	COG3260	NADH ubiquinone oxidoreductase 20
I6L01_RS15550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L01_RS15555	COG4680	protein conserved in bacteria
I6L01_RS15560	COG5499	transcription regulator containing HTH domain
I6L01_RS15565	COG2723	6-phospho-beta-galactosidase activity
I6L01_RS15570	COG1263	PTS System
I6L01_RS15570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS15575	COG1609	Transcriptional regulator
I6L01_RS15580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS15585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L01_RS15610	COG1349	DNA-binding transcription factor activity
I6L01_RS15615	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS15620	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS15630	COG3732	PTS system glucitol sorbitol-specific
I6L01_RS15635	COG3730	PTS system glucitol sorbitol-specific
I6L01_RS15640	COG2951	lytic endotransglycosylase activity
I6L01_RS15645	COG1546	Belongs to the CinA family
I6L01_RS15665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L01_RS15695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L01_RS15700	COG1238	metal cluster binding
I6L01_RS15715	COG2814	Major facilitator Superfamily
I6L01_RS15720	COG1566	PFAM secretion protein HlyD family protein
I6L01_RS15725	COG1846	Transcriptional regulator
I6L01_RS15735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L01_RS15740	COG2814	Major facilitator Superfamily
I6L01_RS15745	COG2113	Glycine betaine
I6L01_RS15750	COG4176	ABC-type proline glycine betaine transport system permease component
I6L01_RS15755	COG4175	Glycine betaine
I6L01_RS15760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L01_RS15765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L01_RS15775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L01_RS15780	COG4575	ribosome binding
I6L01_RS15795	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L01_RS15800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L01_RS15820	COG0401	homolog of Blt101
I6L01_RS15825	COG1652	LysM domain
I6L01_RS15830	COG1802	Transcriptional regulator
I6L01_RS15835	COG1113	amino acid transport
I6L01_RS15840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L01_RS15845	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS15850	COG0579	oxidoreductase
I6L01_RS15860	COG0366	Alpha amylase catalytic
I6L01_RS15885	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS15900	COG2867	negative regulation of translational initiation
I6L01_RS15910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L01_RS15915	COG0497	DNA recombination
I6L01_RS15930	COG4536	flavin adenine dinucleotide binding
I6L01_RS15935	COG4137	Cytochrome C assembly protein
I6L01_RS15940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L01_RS15970	COG2885	chlorophyll binding
I6L01_RS15975	COG2199	diguanylate cyclase activity
I6L01_RS15990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L01_RS15995	COG0287	Prephenate dehydrogenase
I6L01_RS15995	COG1605	Chorismate mutase
I6L01_RS16000	COG0077	Prephenate dehydratase
I6L01_RS16000	COG1605	Chorismate mutase
I6L01_RS16010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L01_RS16015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L01_RS16020	COG0564	pseudouridine synthase activity
I6L01_RS16030	COG0542	response to heat
I6L01_RS16060	COG0477	Major facilitator Superfamily
I6L01_RS16065	COG5544	Lipoprotein
I6L01_RS16070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L01_RS16075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L01_RS16075	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L01_RS16075	COG1042	CoA-binding domain protein
I6L01_RS16080	COG3148	PFAM DTW domain containing protein
I6L01_RS16085	COG3118	belongs to the thioredoxin family
I6L01_RS16090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L01_RS16110	COG0583	DNA-binding transcription factor activity
I6L01_RS16115	COG0513	Belongs to the DEAD box helicase family
I6L01_RS16125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L01_RS16135	COG1595	DNA-templated transcription, initiation
I6L01_RS16140	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L01_RS16145	COG3026	antisigma factor binding
I6L01_RS16150	COG3086	response to oxidative stress
I6L01_RS16160	COG0681	Belongs to the peptidase S26 family
I6L01_RS16180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L01_RS16195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS16200	COG1737	Transcriptional regulator
I6L01_RS16205	COG0560	Phosphoserine phosphatase
I6L01_RS16220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L01_RS16220	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L01_RS16225	COG2205	protein histidine kinase activity
I6L01_RS16230	COG3170	Tfp pilus assembly protein FimV
I6L01_RS16235	COG2204	response regulator
I6L01_RS16240	COG0347	Belongs to the P(II) protein family
I6L01_RS16245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L01_RS16245	COG1017	nitric oxide dioxygenase activity
I6L01_RS16255	COG1940	carbohydrate kinase activity
I6L01_RS16260	COG0457	Tetratricopeptide repeat
I6L01_RS16265	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS16270	COG1129	ABC transporter
I6L01_RS16275	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS16280	COG1063	alcohol dehydrogenase
I6L01_RS16285	COG2017	converts alpha-aldose to the beta-anomer
I6L01_RS16290	COG2259	Doxx family
I6L01_RS16315	COG4638	Rieske (2fe-2S)
I6L01_RS16320	COG0583	DNA-binding transcription factor activity
I6L01_RS16325	COG2814	Major facilitator Superfamily
I6L01_RS16330	COG3711	transcriptional antiterminator
I6L01_RS16335	COG1073	alpha beta
I6L01_RS16340	COG0483	inositol monophosphate 1-phosphatase activity
I6L01_RS16360	COG0822	iron-sulfur transferase activity
I6L01_RS16380	COG0633	Ferredoxin
I6L01_RS16385	COG2975	iron-sulfur cluster assembly
I6L01_RS16400	COG2897	thiosulfate sulfurtransferase activity
I6L01_RS16405	COG2373	Large extracellular alpha-helical protein
I6L01_RS16410	COG4953	penicillin-binding protein 1C
I6L01_RS16440	COG2976	Protein conserved in bacteria
I6L01_RS16455	COG1645	bacterial-type flagellum-dependent swarming motility
I6L01_RS16480	COG0516	GMP reductase activity
I6L01_RS16480	COG0517	IMP dehydrogenase activity
I6L01_RS16495	COG3133	Outer membrane lipoprotein
I6L01_RS16510	COG2200	EAL domain
I6L01_RS16515	COG0248	Ppx GppA phosphatase
I6L01_RS16520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L01_RS16525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L01_RS16540	COG2233	PERMEase
I6L01_RS16550	COG1393	Belongs to the ArsC family
I6L01_RS16555	COG4783	chaperone-mediated protein folding
I6L01_RS16560	COG0628	permease
I6L01_RS16565	COG2116	formate transmembrane transporter activity
I6L01_RS16570	COG3604	Transcriptional regulator
I6L01_RS16580	COG3260	NADH ubiquinone oxidoreductase 20
I6L01_RS16585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L01_RS16590	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L01_RS16590	COG3261	NADH dehydrogenase
I6L01_RS16595	COG0651	ATP synthesis coupled electron transport
I6L01_RS16600	COG4237	Hydrogenase 4 membrane
I6L01_RS16605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L01_RS16610	COG0650	Formate hydrogenlyase subunit 4
I6L01_RS16615	COG0651	ATP synthesis coupled electron transport
I6L01_RS16620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS16625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L01_RS16630	COG2716	regulation of RNA biosynthetic process
I6L01_RS16640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L01_RS16650	COG2321	neutral zinc metallopeptidase
I6L01_RS16660	COG0400	carboxylic ester hydrolase activity
I6L01_RS16675	COG1393	Belongs to the ArsC family
I6L01_RS16685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L01_RS16690	COG3850	Histidine kinase
I6L01_RS16695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS16695	COG0493	'glutamate synthase
I6L01_RS16705	COG5342	invasion associated locus B
I6L01_RS16710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L01_RS16715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L01_RS16720	COG0280	phosphate acetyltransferase
I6L01_RS16720	COG0281	malic enzyme
I6L01_RS16725	COG4810	utilization protein
I6L01_RS16730	COG4917	ethanolamine utilization protein
I6L01_RS16735	COG4766	ethanolamine catabolic process
I6L01_RS16740	COG4812	Cobalamin adenosyltransferase
I6L01_RS16745	COG0280	phosphate acetyltransferase
I6L01_RS16750	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6L01_RS16755	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6L01_RS16760	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS16765	COG4820	ethanolamine utilization protein (EutJ)
I6L01_RS16770	COG1454	alcohol dehydrogenase
I6L01_RS16775	COG3192	ethanolamine utilization protein
I6L01_RS16780	COG4819	ethanolamine utilization protein
I6L01_RS16785	COG4303	Ethanolamine ammonia lyase large subunit
I6L01_RS16795	COG4816	utilization protein
I6L01_RS16800	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6L01_RS16805	COG2207	Transcriptional regulator
I6L01_RS16815	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L01_RS16835	COG2837	iron assimilation
I6L01_RS16845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L01_RS16850	COG1263	PTS System
I6L01_RS16850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS16865	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS16870	COG4150	thiosulfate binding
I6L01_RS16875	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L01_RS16880	COG4208	sulfate ABC transporter
I6L01_RS16885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L01_RS16890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L01_RS16905	COG2190	(PTS) system
I6L01_RS16910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L01_RS16915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS16920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L01_RS16940	COG3530	Putative quorum-sensing-regulated virulence factor
I6L01_RS16945	COG0385	Bile acid
I6L01_RS16950	COG0583	DNA-binding transcription factor activity
I6L01_RS16960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6L01_RS16965	COG2211	Major facilitator Superfamily
I6L01_RS16975	COG0583	DNA-binding transcription factor activity
I6L01_RS17015	COG3415	Transposase
I6L01_RS17020	COG3415	Transposase
I6L01_RS17035	COG2200	EAL domain
I6L01_RS17035	COG2199	diguanylate cyclase activity
I6L01_RS17040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L01_RS17065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS17070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS17075	COG0006	proline dipeptidase activity
I6L01_RS17080	COG1363	Peptidase, m42
I6L01_RS17085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS17085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L01_RS17085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS17090	COG2207	Transcriptional regulator
I6L01_RS17095	COG3279	Response regulator of the LytR AlgR family
I6L01_RS17100	COG3275	phosphorelay sensor kinase activity
I6L01_RS17105	COG0436	Aminotransferase
I6L01_RS17115	COG1560	Kdo2-lipid A biosynthetic process
I6L01_RS17140	COG0028	Belongs to the TPP enzyme family
I6L01_RS17145	COG0679	Auxin Efflux Carrier
I6L01_RS17150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L01_RS17155	COG2205	protein histidine kinase activity
I6L01_RS17155	COG2198	Histidine kinase
I6L01_RS17155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS17155	COG0784	Response regulator, receiver
I6L01_RS17160	COG2197	response regulator
I6L01_RS17165	COG1566	PFAM secretion protein HlyD family protein
I6L01_RS17170	COG0477	Major facilitator Superfamily
I6L01_RS17260	COG0582	viral genome integration into host DNA
I6L01_RS17270	COG2116	formate transmembrane transporter activity
I6L01_RS17275	COG2853	Lipoprotein
I6L01_RS17285	COG2067	long-chain fatty acid transport protein
I6L01_RS17290	COG3691	Protein conserved in bacteria
I6L01_RS17305	COG2062	phosphohistidine phosphatase, SixA
I6L01_RS17310	COG3539	Fimbrial protein
I6L01_RS17315	COG3188	usher protein
I6L01_RS17320	COG3121	Chaperone
I6L01_RS17325	COG3539	Fimbrial protein
I6L01_RS17330	COG3539	Fimbrial protein
I6L01_RS17335	COG3539	Fimbrial protein
I6L01_RS17350	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L01_RS17365	COG0730	response to heat
I6L01_RS17370	COG3101	peptidyl-lysine hydroxylation
I6L01_RS17385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L01_RS17390	COG2814	Major facilitator Superfamily
I6L01_RS17405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L01_RS17415	COG0586	Pfam SNARE associated Golgi protein
I6L01_RS17425	COG0285	dihydrofolate synthase activity
I6L01_RS17430	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L01_RS17435	COG1286	toxin biosynthetic process
I6L01_RS17440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L01_RS17445	COG0163	prenyltransferase activity
I6L01_RS17450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS17455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS17460	COG4215	(ABC) transporter
I6L01_RS17465	COG4160	amino acid transport
I6L01_RS17470	COG4598	ABC transporter
I6L01_RS17475	COG5464	transposase or invertase
I6L01_RS17480	COG1090	epimerase
I6L01_RS17485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L01_RS17490	COG0625	glutathione transferase activity
I6L01_RS17495	COG0625	glutathione transferase activity
I6L01_RS17500	COG0622	Phosphoesterase
I6L01_RS17505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L01_RS17510	COG1288	antiporter activity
I6L01_RS17515	COG0280	phosphate acetyltransferase
I6L01_RS17515	COG0857	belongs to the CobB CobQ family
I6L01_RS17520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L01_RS17535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L01_RS17540	COG0471	metal ion transport
I6L01_RS17540	COG0490	domain, Protein
I6L01_RS17550	COG0436	Aminotransferase
I6L01_RS17555	COG0583	DNA-binding transcription factor activity
I6L01_RS17575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6L01_RS17580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L01_RS17585	COG1034	ATP synthesis coupled electron transport
I6L01_RS17600	COG0839	Belongs to the complex I subunit 6 family
I6L01_RS17610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L01_RS17615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L01_RS17630	COG2234	aminopeptidase activity
I6L01_RS17635	COG5160	protein modification by small protein removal
I6L01_RS17645	COG2153	protein acetylation
I6L01_RS17650	COG4575	ribosome binding
I6L01_RS17655	COG1169	isochorismate synthase
I6L01_RS17670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L01_RS17680	COG0318	PFAM AMP-dependent synthetase and ligase
I6L01_RS17745	COG1414	Transcriptional regulator
I6L01_RS17755	COG2271	Major facilitator Superfamily
I6L01_RS17770	COG5464	transposase or invertase
I6L01_RS17775	COG0247	lactate metabolic process
I6L01_RS17785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L01_RS17790	COG2271	Major facilitator Superfamily
I6L01_RS17795	COG0584	glycerophosphoryl diester phosphodiesterase
I6L01_RS17800	COG0583	DNA-binding transcription factor activity
I6L01_RS17805	COG2814	Major facilitator Superfamily
I6L01_RS17810	COG3642	lipopolysaccharide core region biosynthetic process
I6L01_RS17815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L01_RS17820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L01_RS17825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L01_RS17830	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS17840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6L01_RS17845	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6L01_RS17850	COG3234	Protein of unknown function (DUF1175)
I6L01_RS17855	COG2373	Large extracellular alpha-helical protein
I6L01_RS17860	COG5445	Predicted secreted protein (DUF2300)
I6L01_RS17865	COG4676	Protein conserved in bacteria
I6L01_RS17870	COG0183	Belongs to the thiolase family
I6L01_RS17875	COG2031	fatty acid transporter
I6L01_RS17880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L01_RS17885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L01_RS17890	COG2204	response regulator
I6L01_RS17895	COG3852	Histidine kinase
I6L01_RS17900	COG2205	protein histidine kinase activity
I6L01_RS17900	COG0784	Response regulator, receiver
I6L01_RS17905	COG2197	response regulator
I6L01_RS17910	COG2198	Histidine kinase
I6L01_RS17910	COG0642	Histidine kinase
I6L01_RS17915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L01_RS17920	COG1477	protein flavinylation
I6L01_RS17925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L01_RS17925	COG2169	Transcriptional regulator
I6L01_RS17930	COG3145	DNA-N1-methyladenine dioxygenase activity
I6L01_RS17935	COG4615	Cyclic peptide transporter
I6L01_RS17950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS17950	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L01_RS17955	COG3062	negative regulation of establishment of protein localization
I6L01_RS17965	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS17970	COG0348	domain, Protein
I6L01_RS17975	COG3043	anaerobic respiration
I6L01_RS17980	COG3005	denitrification pathway
I6L01_RS17985	COG4133	protoheme IX ABC transporter activity
I6L01_RS17990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L01_RS17995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L01_RS18000	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L01_RS18010	COG1138	Cytochrome C-type biogenesis protein
I6L01_RS18015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L01_RS18020	COG3088	subunit of a heme lyase
I6L01_RS18020	COG4235	cytochrome complex assembly
I6L01_RS18025	COG2197	response regulator
I6L01_RS18030	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS18040	COG3083	sulfuric ester hydrolase activity
I6L01_RS18060	COG1061	Type III restriction enzyme res subunit
I6L01_RS18065	COG1187	pseudouridine synthase activity
I6L01_RS18070	COG2814	Major facilitator Superfamily
I6L01_RS18080	COG4172	Belongs to the ABC transporter superfamily
I6L01_RS18085	COG4239	(ABC) transporter, permease
I6L01_RS18090	COG4174	ABC transporter (Permease)
I6L01_RS18095	COG4166	transmembrane transport
I6L01_RS18100	COG2200	EAL domain
I6L01_RS18105	COG0791	NLP P60 protein
I6L01_RS18110	COG0671	phosphoesterase, PA-phosphatase related
I6L01_RS18115	COG0523	cobalamin synthesis protein
I6L01_RS18120	COG0246	Mannitol dehydrogenase
I6L01_RS18135	COG2814	Major facilitator Superfamily
I6L01_RS18140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS18140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS18145	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L01_RS18150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS18150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L01_RS18150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L01_RS18155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS18160	COG2313	pseudouridylate synthase activity
I6L01_RS18165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L01_RS18170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L01_RS18180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L01_RS18185	COG1522	sequence-specific DNA binding
I6L01_RS18185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS18195	COG2855	membrane
I6L01_RS18200	COG0583	DNA-binding transcription factor activity
I6L01_RS18205	COG0833	amino acid
I6L01_RS18210	COG4771	TonB-dependent receptor
I6L01_RS18225	COG2311	Membrane
I6L01_RS18230	COG1609	Transcriptional regulator
I6L01_RS18235	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS18240	COG1129	ABC transporter
I6L01_RS18245	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS18250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L01_RS18250	COG0167	dihydroorotate dehydrogenase activity
I6L01_RS18255	COG0493	'glutamate synthase
I6L01_RS18265	COG2949	membrane
I6L01_RS18275	COG1346	cytolysis
I6L01_RS18285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L01_RS18295	COG1538	Outer membrane efflux protein
I6L01_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS18305	COG0586	Pfam SNARE associated Golgi protein
I6L01_RS18315	COG1686	Belongs to the peptidase S11 family
I6L01_RS18320	COG0277	FAD linked oxidase domain protein
I6L01_RS18325	COG1472	Belongs to the glycosyl hydrolase 3 family
I6L01_RS18330	COG1732	Glycine betaine
I6L01_RS18335	COG1174	glycine betaine transport
I6L01_RS18340	COG1125	glycine betaine transport
I6L01_RS18345	COG1174	glycine betaine transport
I6L01_RS18355	COG0789	Transcriptional regulator
I6L01_RS18360	COG3275	phosphorelay sensor kinase activity
I6L01_RS18365	COG3279	Response regulator of the LytR AlgR family
I6L01_RS18370	COG4807	Protein conserved in bacteria
I6L01_RS18375	COG4808	Protein conserved in bacteria
I6L01_RS18380	COG4715	Zinc finger, swim domain protein
I6L01_RS18385	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6L01_RS18390	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L01_RS18400	COG3831	ATPase activity
I6L01_RS18405	COG3831	ATPase activity
I6L01_RS18415	COG0489	protein tyrosine kinase activity
I6L01_RS18425	COG3539	Fimbrial protein
I6L01_RS18430	COG3121	Chaperone
I6L01_RS18435	COG3188	usher protein
I6L01_RS18440	COG3539	Fimbrial protein
I6L01_RS18445	COG5455	response to cobalt ion
I6L01_RS18465	COG0351	phosphomethylpyrimidine kinase
I6L01_RS18470	COG3757	hydrolase, family 25
I6L01_RS18475	COG2188	Transcriptional regulator
I6L01_RS18480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS18485	COG1397	ADP-ribosylglycohydrolase
I6L01_RS18490	COG2211	Major facilitator Superfamily
I6L01_RS18495	COG1830	Aldolase
I6L01_RS18510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS18515	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L01_RS18530	COG4372	Transposase
I6L01_RS18535	COG3436	PFAM IS66 Orf2 family protein
I6L01_RS18570	COG0640	Transcriptional regulator
I6L01_RS18585	COG0786	glutamate:sodium symporter activity
I6L01_RS18605	COG1063	alcohol dehydrogenase
I6L01_RS18625	COG4974	Belongs to the 'phage' integrase family
I6L01_RS18690	COG4695	Portal protein
I6L01_RS18785	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6L01_RS18825	COG4584	PFAM Integrase catalytic
I6L01_RS18830	COG1484	DNA-dependent DNA replication
I6L01_RS18855	COG0826	peptidase U32
I6L01_RS18865	COG0745	RESPONSE REGULATOR receiver
I6L01_RS18870	COG2205	protein histidine kinase activity
I6L01_RS18910	COG4245	von Willebrand factor, type A
I6L01_RS18915	COG0631	protein serine/threonine phosphatase activity
I6L01_RS18920	COG3779	Protein conserved in bacteria
I6L01_RS18925	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6L01_RS18930	COG0443	Heat shock 70 kDa protein
I6L01_RS18935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6L01_RS18940	COG5001	Diguanylate cyclase
I6L01_RS18940	COG5002	protein histidine kinase activity
I6L01_RS18940	COG3447	MASE1 domain protein
I6L01_RS18945	COG0572	uridine kinase
I6L01_RS18955	COG2982	Protein involved in outer membrane biogenesis
I6L01_RS18960	COG1253	flavin adenine dinucleotide binding
I6L01_RS18965	COG1596	polysaccharide export
I6L01_RS18970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L01_RS18975	COG3206	protein involved in exopolysaccharide biosynthesis
I6L01_RS18975	COG0489	protein tyrosine kinase activity
I6L01_RS18980	COG0463	Glycosyl transferase, family 2
I6L01_RS18985	COG1045	serine acetyltransferase
I6L01_RS18990	COG0438	transferase activity, transferring glycosyl groups
I6L01_RS19000	COG1216	Glycosyl transferase, family 2
I6L01_RS19005	COG0110	maltose O-acetyltransferase activity
I6L01_RS19010	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6L01_RS19015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L01_RS19020	COG1051	belongs to the nudix hydrolase family
I6L01_RS19025	COG0297	glycogen (starch) synthase activity
I6L01_RS19030	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6L01_RS19030	COG0662	Cupin 2, conserved barrel domain protein
I6L01_RS19035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L01_RS19040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L01_RS19045	COG2244	polysaccharide biosynthetic process
I6L01_RS19050	COG2327	Polysaccharide pyruvyl transferase
I6L01_RS19055	COG0438	transferase activity, transferring glycosyl groups
I6L01_RS19065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L01_RS19070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L01_RS19075	COG1088	dTDP-glucose 4,6-dehydratase activity
I6L01_RS19085	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L01_RS19100	COG0438	transferase activity, transferring glycosyl groups
I6L01_RS19100	COG4641	Protein conserved in bacteria
I6L01_RS19110	COG1216	Glycosyl transferase, family 2
I6L01_RS19130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6L01_RS19135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6L01_RS19160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L01_RS19165	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L01_RS19165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L01_RS19190	COG2161	toxin-antitoxin pair type II binding
I6L01_RS19195	COG4115	mRNA cleavage
I6L01_RS19200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L01_RS19205	COG0583	DNA-binding transcription factor activity
I6L01_RS19215	COG0531	amino acid
I6L01_RS19220	COG2391	methyltransferase activity
I6L01_RS19225	COG0425	Belongs to the sulfur carrier protein TusA family
I6L01_RS19230	COG2925	Exonuclease
I6L01_RS19235	COG1686	Belongs to the peptidase S11 family
I6L01_RS19245	COG1289	transmembrane transporter activity
I6L01_RS19290	COG2003	Belongs to the UPF0758 family
I6L01_RS19395	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6L01_RS19430	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6L01_RS19445	COG1376	ErfK ybiS ycfS ynhG family protein
I6L01_RS19455	COG0583	DNA-binding transcription factor activity
I6L01_RS19460	COG0583	DNA-binding transcription factor activity
I6L01_RS19470	COG0534	Mate efflux family protein
I6L01_RS19480	COG0217	transcriptional regulatory protein
I6L01_RS19485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L01_RS19490	COG0477	Major facilitator Superfamily
I6L01_RS19505	COG1388	LysM domain
I6L01_RS19505	COG2373	Large extracellular alpha-helical protein
I6L01_RS19505	COG4932	domain protein
I6L01_RS19510	COG4771	TonB-dependent receptor
I6L01_RS19515	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L01_RS19535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L01_RS19535	COG2226	methyltransferase
I6L01_RS19535	COG3433	isochorismatase activity
I6L01_RS19550	COG1132	(ABC) transporter
I6L01_RS19555	COG2814	Major facilitator Superfamily
I6L01_RS19560	COG1169	isochorismate synthase
I6L01_RS19585	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6L01_RS19600	COG2351	hydroxyisourate hydrolase activity
I6L01_RS19605	COG0745	RESPONSE REGULATOR receiver
I6L01_RS19610	COG2205	protein histidine kinase activity
I6L01_RS19630	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6L01_RS19635	COG3727	T/G mismatch-specific endonuclease activity
I6L01_RS19640	COG0697	spore germination
I6L01_RS19645	COG2354	Protein conserved in bacteria
I6L01_RS19650	COG5475	Uncharacterized small protein (DUF2158)
I6L01_RS19675	COG2197	response regulator
I6L01_RS19680	COG1684	flagellar biosynthetic protein fliR
I6L01_RS19685	COG1987	bacterial-type flagellum assembly
I6L01_RS19690	COG1338	Plays a role in the flagellum-specific transport system
I6L01_RS19695	COG3190	flagellar
I6L01_RS19700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L01_RS19705	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L01_RS19710	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L01_RS19715	COG3144	bacterial-type flagellum assembly
I6L01_RS19720	COG2882	bacterial-type flagellum organization
I6L01_RS19725	COG1157	protein secretion by the type III secretion system
I6L01_RS19730	COG1317	bacterial-type flagellum organization
I6L01_RS19735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L01_RS19740	COG1766	The M ring may be actively involved in energy transduction
I6L01_RS19750	COG2076	Multidrug Resistance protein
I6L01_RS19755	COG1881	PFAM PEBP family protein
I6L01_RS19760	COG2207	Transcriptional regulator
I6L01_RS19775	COG2135	peptidase activity
I6L01_RS19780	COG0425	Belongs to the sulfur carrier protein TusA family
I6L01_RS19785	COG2391	methyltransferase activity
I6L01_RS19795	COG0366	Alpha amylase catalytic
I6L01_RS19805	COG1516	flagellar protein fliS
I6L01_RS19810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6L01_RS19820	COG1191	sigma factor activity
I6L01_RS19830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L01_RS19840	COG0765	amino acid transport
I6L01_RS19845	COG1126	abc transporter atp-binding protein
I6L01_RS19850	COG2197	response regulator
I6L01_RS19865	COG2197	response regulator
I6L01_RS19895	COG3318	Belongs to the UPF0149 family
I6L01_RS19895	COG3012	SEC-C Motif Domain Protein
I6L01_RS19900	COG0814	amino acid
I6L01_RS19910	COG1528	Iron-storage protein
I6L01_RS19930	COG1528	Iron-storage protein
I6L01_RS19935	COG1879	ABC-type sugar transport system periplasmic component
I6L01_RS19940	COG1129	ABC transporter
I6L01_RS19945	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L01_RS19950	COG1877	trehalose-phosphatase activity
I6L01_RS19960	COG0589	response to stress
I6L01_RS19975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L01_RS19980	COG1360	Flagellar Motor Protein
I6L01_RS19985	COG2198	Histidine kinase
I6L01_RS19985	COG0643	Histidine kinase
I6L01_RS19990	COG0835	chemotaxis
I6L01_RS19995	COG0840	transmembrane signaling receptor activity
I6L01_RS20000	COG0840	transmembrane signaling receptor activity
I6L01_RS20005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L01_RS20015	COG0745	RESPONSE REGULATOR receiver
I6L01_RS20020	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L01_RS20025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L01_RS20030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L01_RS20045	COG3102	Protein conserved in bacteria
I6L01_RS20055	COG3005	denitrification pathway
I6L01_RS20060	COG0243	molybdopterin cofactor binding
I6L01_RS20075	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L01_RS20080	COG1801	Protein of unknown function DUF72
I6L01_RS20085	COG1335	isochorismatase
I6L01_RS20095	COG0494	nUDIX hydrolase
I6L01_RS20100	COG0217	transcriptional regulatory protein
I6L01_RS20130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L01_RS20140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L01_RS20145	COG0739	heme binding
I6L01_RS20150	COG1560	Kdo2-lipid A biosynthetic process
I6L01_RS20155	COG0469	pyruvate kinase activity
I6L01_RS20160	COG1737	Transcriptional regulator
I6L01_RS20165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6L01_RS20170	COG0129	dihydroxy-acid dehydratase activity
I6L01_RS20175	COG0800	Aldolase
I6L01_RS20185	COG3141	response to X-ray
I6L01_RS20195	COG2979	Protein of unknown function (DUF533)
I6L01_RS20200	COG1770	oligopeptidase
I6L01_RS20205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L01_RS20210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L01_RS20220	COG2372	response to copper ion
I6L01_RS20225	COG1276	copper resistance
I6L01_RS20235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L01_RS20255	COG3008	intermembrane lipid transfer
I6L01_RS20260	COG2995	paraquat-inducible protein a
I6L01_RS20265	COG1956	GAF domain-containing protein
I6L01_RS20275	COG0793	Belongs to the peptidase S41A family
I6L01_RS20285	COG2814	Major facilitator Superfamily
I6L01_RS20290	COG1414	Transcriptional regulator
I6L01_RS20320	COG2226	methyltransferase
I6L01_RS20335	COG3716	PTS system mannose fructose sorbose family IID component
I6L01_RS20340	COG3715	PTS system
I6L01_RS20345	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS20345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS20350	COG1253	flavin adenine dinucleotide binding
I6L01_RS20355	COG2200	EAL domain
I6L01_RS20360	COG1760	l-serine dehydratase
I6L01_RS20370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L01_RS20385	COG0251	oxidation-reduction process
I6L01_RS20390	COG1199	ATP-dependent helicase activity
I6L01_RS20395	COG1214	PFAM Peptidase M22, glycoprotease
I6L01_RS20400	COG3065	identical protein binding
I6L01_RS20405	COG0318	PFAM AMP-dependent synthetase and ligase
I6L01_RS20410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L01_RS20420	COG4638	Rieske (2fe-2S)
I6L01_RS20425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L01_RS20430	COG0473	3-isopropylmalate dehydrogenase activity
I6L01_RS20435	COG0583	DNA-binding transcription factor activity
I6L01_RS20445	COG3615	Tellurite resistance protein tehB
I6L01_RS20455	COG2261	transglycosylase associated protein
I6L01_RS20470	COG2199	diguanylate cyclase activity
I6L01_RS20470	COG2203	Gaf domain
I6L01_RS20475	COG3042	response to heat
I6L01_RS20480	COG3189	MarR family transcriptional regulator
I6L01_RS20485	COG2807	transmembrane transport
I6L01_RS20490	COG2207	Transcriptional regulator
I6L01_RS20505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L01_RS20510	COG2199	diguanylate cyclase activity
I6L01_RS20515	COG2199	diguanylate cyclase activity
I6L01_RS20525	COG2766	serine protein kinase
I6L01_RS20530	COG3713	MltA-interacting MipA family protein
I6L01_RS20535	COG0656	L-ascorbic acid biosynthetic process
I6L01_RS20540	COG0676	glucose-6-phosphate 1-epimerase activity
I6L01_RS20545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L01_RS20555	COG3139	Protein of unknown function (DUF1315)
I6L01_RS20560	COG1063	alcohol dehydrogenase
I6L01_RS20565	COG2271	Major facilitator Superfamily
I6L01_RS20570	COG1063	alcohol dehydrogenase
I6L01_RS20575	COG0191	fructose-bisphosphate aldolase activity
I6L01_RS20580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L01_RS20585	COG0667	Aldo Keto reductase
I6L01_RS20590	COG1349	DNA-binding transcription factor activity
I6L01_RS20595	COG2814	Major facilitator Superfamily
I6L01_RS20600	COG1335	isochorismatase
I6L01_RS20605	COG0252	asparaginase activity
I6L01_RS20610	COG0616	signal peptide processing
I6L01_RS20615	COG0778	Nitroreductase
I6L01_RS20625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L01_RS20630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L01_RS20640	COG0494	nUDIX hydrolase
I6L01_RS20645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L01_RS20650	COG2897	thiosulfate sulfurtransferase activity
I6L01_RS20655	COG4136	ATPase activity
I6L01_RS20660	COG4135	transport system, permease component
I6L01_RS20665	COG4134	Bacterial extracellular solute-binding protein
I6L01_RS20670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L01_RS20675	COG0398	Pfam SNARE associated Golgi protein
I6L01_RS20685	COG0398	Pfam SNARE associated Golgi protein
I6L01_RS20695	COG0708	Exodeoxyribonuclease III
I6L01_RS20725	COG3678	ATP-independent chaperone mediated protein folding
I6L01_RS20735	COG0322	excinuclease ABC activity
I6L01_RS20745	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L01_RS20750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L01_RS20755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L01_RS20760	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L01_RS20765	COG2169	Transcriptional regulator
I6L01_RS20765	COG1917	Cupin 2, conserved barrel domain protein
I6L01_RS20770	COG1486	melibiose metabolic process
I6L01_RS20775	COG3394	polysaccharide catabolic process
I6L01_RS20780	COG0753	catalase activity
I6L01_RS20795	COG1823	symporter activity
I6L01_RS20800	COG1988	membrane-bound metal-dependent
I6L01_RS20805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L01_RS20815	COG3001	Fructosamine kinase
I6L01_RS20825	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L01_RS20830	COG3137	Salt-induced outer membrane protein
I6L01_RS20890	COG0386	Belongs to the glutathione peroxidase family
I6L01_RS20900	COG0791	NLP P60 protein
I6L01_RS20905	COG2200	EAL domain
I6L01_RS20915	COG4256	Hemin uptake protein
I6L01_RS20920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L01_RS20930	COG0574	Belongs to the PEP-utilizing enzyme family
I6L01_RS20930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L01_RS20935	COG0318	PFAM AMP-dependent synthetase and ligase
I6L01_RS20940	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L01_RS20945	COG0644	oxidoreductase
I6L01_RS20950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6L01_RS20955	COG2086	electron transfer activity
I6L01_RS20960	COG2207	Transcriptional regulator
I6L01_RS20960	COG1917	Cupin 2, conserved barrel domain protein
I6L01_RS20965	COG1960	acyl-CoA dehydrogenase activity
I6L01_RS20970	COG4670	ketone body catabolic process
I6L01_RS20985	COG2271	Major facilitator Superfamily
I6L01_RS20990	COG0738	Major facilitator superfamily
I6L01_RS21005	COG0628	permease
I6L01_RS21010	COG0277	FAD linked oxidase domain protein
I6L01_RS21010	COG0247	lactate metabolic process
I6L01_RS21015	COG2050	protein possibly involved in aromatic compounds catabolism
I6L01_RS21025	COG0316	Belongs to the HesB IscA family
I6L01_RS21030	COG0719	Fe-S assembly protein
I6L01_RS21035	COG0396	ATPase activity
I6L01_RS21040	COG0719	Fe-S assembly protein
I6L01_RS21055	COG1376	ErfK ybiS ycfS ynhG family protein
I6L01_RS21060	COG4238	major outer membrane lipoprotein
I6L01_RS21065	COG0469	pyruvate kinase activity
I6L01_RS21075	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS21080	COG2414	aldehyde ferredoxin oxidoreductase
I6L01_RS21090	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS21095	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6L01_RS21105	COG4529	Protein conserved in bacteria
I6L01_RS21125	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS21135	COG0307	riboflavin synthase, alpha
I6L01_RS21140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L01_RS21145	COG2814	Major facilitator Superfamily
I6L01_RS21150	COG0583	DNA-binding transcription factor activity
I6L01_RS21165	COG2814	Major facilitator Superfamily
I6L01_RS21170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L01_RS21175	COG0791	NLP P60 protein
I6L01_RS21180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L01_RS21185	COG1201	RNA secondary structure unwinding
I6L01_RS21195	COG0346	lactoylglutathione lyase activity
I6L01_RS21200	COG1902	pentaerythritol trinitrate reductase activity
I6L01_RS21205	COG1309	transcriptional regulator
I6L01_RS21210	COG3313	Fe-S protein
I6L01_RS21215	COG4989	oxidoreductase activity
I6L01_RS21220	COG2032	superoxide dismutase activity
I6L01_RS21225	COG1289	transmembrane transporter activity
I6L01_RS21230	COG1566	PFAM secretion protein HlyD family protein
I6L01_RS21245	COG3133	Outer membrane lipoprotein
I6L01_RS21255	COG3895	Periplasmic Protein
I6L01_RS21270	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L01_RS21275	COG0625	glutathione transferase activity
I6L01_RS21280	COG3104	oligopeptide transport
I6L01_RS21285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L01_RS21295	COG4659	FMN binding
I6L01_RS21335	COG0673	inositol 2-dehydrogenase activity
I6L01_RS21345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L01_RS21350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L01_RS21350	COG1263	PTS System
I6L01_RS21355	COG1609	Transcriptional regulator
I6L01_RS21360	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS21365	COG1309	transcriptional regulator
I6L01_RS21370	COG3250	beta-galactosidase activity
I6L01_RS21385	COG5339	Protein conserved in bacteria
I6L01_RS21390	COG1482	cell wall glycoprotein biosynthetic process
I6L01_RS21395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS21395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L01_RS21400	COG0114	fumarate hydratase activity
I6L01_RS21410	COG2205	protein histidine kinase activity
I6L01_RS21415	COG0745	RESPONSE REGULATOR receiver
I6L01_RS21420	COG3136	membrane protein required for alginate biosynthesis
I6L01_RS21430	COG0531	amino acid
I6L01_RS21440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L01_RS21445	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L01_RS21450	COG0628	permease
I6L01_RS21465	COG3591	Belongs to the peptidase S1B family
I6L01_RS21480	COG2814	Major facilitator Superfamily
I6L01_RS21485	COG0583	DNA-binding transcription factor activity
I6L01_RS21490	COG1940	carbohydrate kinase activity
I6L01_RS21495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L01_RS21505	COG3381	protein complex oligomerization
I6L01_RS21510	COG3302	dmso reductase anchor subunit
I6L01_RS21515	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS21520	COG0243	molybdopterin cofactor binding
I6L01_RS21525	COG0243	molybdopterin cofactor binding
I6L01_RS21540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L01_RS21555	COG4948	Mandelate Racemase Muconate Lactonizing
I6L01_RS21560	COG1063	alcohol dehydrogenase
I6L01_RS21570	COG0582	viral genome integration into host DNA
I6L01_RS21580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L01_RS21605	COG1396	sequence-specific DNA binding
I6L01_RS21620	COG1846	Transcriptional regulator
I6L01_RS21630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L01_RS21645	COG2801	Transposase and inactivated derivatives
I6L01_RS21660	COG3077	Addiction module antitoxin, RelB DinJ family
I6L01_RS21665	COG2026	Addiction module toxin, RelE StbE family
I6L01_RS21685	COG1403	HNH endonuclease
I6L01_RS21690	COG0484	heat shock protein binding
I6L01_RS21700	COG1278	Cold shock
I6L01_RS21705	COG1278	Cold shock
I6L01_RS21725	COG3772	lysozyme
I6L01_RS21735	COG1278	Cold shock
I6L01_RS21760	COG5562	phage envelope protein
I6L01_RS21770	COG4220	transposase activity
I6L01_RS21790	COG1030	water channel activity
I6L01_RS21840	COG1196	nuclear chromosome segregation
I6L01_RS21875	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6L01_RS21900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L01_RS21920	COG0246	Mannitol dehydrogenase
I6L01_RS21930	COG1802	Transcriptional regulator
I6L01_RS21935	COG4221	oxidoreductase activity
I6L01_RS21940	COG0339	signal peptide processing
I6L01_RS21945	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L01_RS21950	COG3706	GGDEF domain
I6L01_RS21960	COG2814	Major facilitator Superfamily
I6L01_RS21965	COG0697	spore germination
I6L01_RS21970	COG2188	Transcriptional regulator
I6L01_RS21985	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L01_RS21995	COG2723	6-phospho-beta-galactosidase activity
I6L01_RS22005	COG4977	sequence-specific DNA binding
I6L01_RS22030	COG0583	DNA-binding transcription factor activity
I6L01_RS22035	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS22040	COG2066	Belongs to the glutaminase family
I6L01_RS22050	COG2199	diguanylate cyclase activity
I6L01_RS22060	COG3781	membrane
I6L01_RS22120	COG1396	sequence-specific DNA binding
I6L01_RS22150	COG0656	L-ascorbic acid biosynthetic process
I6L01_RS22160	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L01_RS22165	COG0667	Aldo Keto reductase
I6L01_RS22185	COG3539	Fimbrial protein
I6L01_RS22195	COG3188	usher protein
I6L01_RS22200	COG3539	Fimbrial protein
I6L01_RS22205	COG3539	Fimbrial protein
I6L01_RS22210	COG3539	Fimbrial protein
I6L01_RS22215	COG0243	molybdopterin cofactor binding
I6L01_RS22230	COG3119	arylsulfatase activity
I6L01_RS22235	COG0641	radical SAM
I6L01_RS22245	COG4178	(ABC) transporter
I6L01_RS22250	COG4771	TonB-dependent receptor
I6L01_RS22255	COG0612	Peptidase, M16
I6L01_RS22260	COG0076	glutamate decarboxylase activity
I6L01_RS22265	COG0531	amino acid
I6L01_RS22270	COG1649	PFAM Uncharacterised BCR, COG1649
I6L01_RS22285	COG2199	diguanylate cyclase activity
I6L01_RS22285	COG2200	EAL domain
I6L01_RS22285	COG2202	Pas domain
I6L01_RS22290	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6L01_RS22295	COG0747	negative chemotaxis
I6L01_RS22300	COG0601	transmembrane transport
I6L01_RS22305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L01_RS22310	COG0444	Belongs to the ABC transporter superfamily
I6L01_RS22315	COG4608	Belongs to the ABC transporter superfamily
I6L01_RS22320	COG1764	response to oxidative stress
I6L01_RS22340	COG1064	alcohol dehydrogenase
I6L01_RS22345	COG3093	addiction module antidote protein HigA
I6L01_RS22355	COG2864	formate dehydrogenase
I6L01_RS22360	COG0437	4 iron, 4 sulfur cluster binding
I6L01_RS22370	COG0697	spore germination
I6L01_RS22390	COG2223	nitrite transmembrane transporter activity
I6L01_RS22395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6L01_RS22400	COG1140	nitrate reductase beta subunit
I6L01_RS22405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6L01_RS22410	COG2181	nitrate reductase activity
I6L01_RS22415	COG0384	phenazine biosynthesis protein PhzF
I6L01_RS22420	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6L01_RS22425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L01_RS22435	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L01_RS22455	COG3209	COG3209 Rhs family protein
I6L01_RS22470	COG0625	glutathione transferase activity
I6L01_RS22475	COG1113	amino acid transport
I6L01_RS22480	COG3391	amine dehydrogenase activity
I6L01_RS22485	COG4772	TonB-dependent receptor
I6L01_RS22490	COG1802	Transcriptional regulator
I6L01_RS22495	COG2130	NADP-dependent
I6L01_RS22500	COG1247	-acetyltransferase
I6L01_RS22505	COG3238	Protein conserved in bacteria
I6L01_RS22530	COG1177	transmembrane transport
I6L01_RS22535	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L01_RS22540	COG3842	ATPase activity
I6L01_RS22545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L01_RS22550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L01_RS22555	COG1598	PFAM Uncharacterised protein family UPF0150
I6L01_RS22560	COG1724	mRNA binding
I6L01_RS22570	COG0826	peptidase U32
I6L01_RS22575	COG1396	sequence-specific DNA binding
I6L01_RS22580	COG3135	benzoate transporter
I6L01_RS22595	COG0500	methyltransferase
I6L01_RS22600	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6L01_RS22605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L01_RS22610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L01_RS22615	COG2841	Protein conserved in bacteria
I6L01_RS22625	COG5383	Protein conserved in bacteria
I6L01_RS22630	COG0583	DNA-binding transcription factor activity
I6L01_RS22635	COG0840	transmembrane signaling receptor activity
I6L01_RS22655	COG3038	cytochrome b561
I6L01_RS22660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L01_RS22665	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS22670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L01_RS22690	COG1643	Atp-dependent helicase
I6L01_RS22700	COG2453	phosphatase
I6L01_RS22700	COG0671	phosphoesterase, PA-phosphatase related
I6L01_RS22705	COG2267	carboxylic ester hydrolase activity
I6L01_RS22715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L01_RS22725	COG0667	Aldo Keto reductase
I6L01_RS22735	COG3784	Protein of unknown function (DUF1318)
I6L01_RS22745	COG2911	Protein conserved in bacteria
I6L01_RS22750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L01_RS22755	COG3187	Heat shock protein
I6L01_RS22760	COG3042	response to heat
I6L01_RS22765	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L01_RS22765	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L01_RS22765	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L01_RS22765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L01_RS22770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L01_RS22775	COG0589	response to stress
I6L01_RS22785	COG0513	Belongs to the DEAD box helicase family
I6L01_RS22805	COG3706	GGDEF domain
I6L01_RS22810	COG2840	Smr protein MutS2
I6L01_RS22825	COG2207	Transcriptional regulator
I6L01_RS22830	COG0583	DNA-binding transcription factor activity
I6L01_RS22835	COG1473	amidohydrolase
I6L01_RS22840	COG1473	amidohydrolase
I6L01_RS22845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L01_RS22850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L01_RS22855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L01_RS22860	COG0589	response to stress
I6L01_RS22865	COG3182	Iron-regulated membrane protein
I6L01_RS22870	COG0668	transmembrane transport
I6L01_RS22875	COG4166	transmembrane transport
I6L01_RS22880	COG0583	DNA-binding transcription factor activity
I6L01_RS22885	COG1073	alpha beta
I6L01_RS22890	COG0702	epimerase
I6L01_RS22895	COG2866	Carboxypeptidase
I6L01_RS22900	COG4948	Mandelate Racemase Muconate Lactonizing
I6L01_RS22905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6L01_RS22910	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6L01_RS22920	COG3106	COG3106 Predicted ATPase
I6L01_RS22925	COG1609	Transcriptional regulator
I6L01_RS22935	COG3842	ATPase activity
I6L01_RS22945	COG1554	hydrolase, family 65, central catalytic
I6L01_RS22950	COG0673	inositol 2-dehydrogenase activity
I6L01_RS22955	COG1082	Xylose isomerase domain protein TIM barrel
I6L01_RS22960	COG1063	alcohol dehydrogenase
I6L01_RS22965	COG0395	ABC-type sugar transport system, permease component
I6L01_RS22970	COG1175	transmembrane transport
I6L01_RS22975	COG1653	transport
I6L01_RS22980	COG0366	Alpha amylase catalytic
I6L01_RS22985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L01_RS22995	COG1983	PspC domain protein
I6L01_RS23005	COG1842	Phage shock protein A
I6L01_RS23010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L01_RS23020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L01_RS23025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L01_RS23030	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS23035	COG1396	sequence-specific DNA binding
I6L01_RS23035	COG1917	Cupin 2, conserved barrel domain protein
I6L01_RS23040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L01_RS23045	COG0174	glutamine synthetase
I6L01_RS23055	COG0531	amino acid
I6L01_RS23065	COG4166	transmembrane transport
I6L01_RS23070	COG4168	peptide transport system, permease
I6L01_RS23075	COG4171	peptide transport system, permease
I6L01_RS23080	COG4172	Belongs to the ABC transporter superfamily
I6L01_RS23085	COG4172	Belongs to the ABC transporter superfamily
I6L01_RS23090	COG2814	Major facilitator Superfamily
I6L01_RS23100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L01_RS23105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L01_RS23115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L01_RS23120	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L01_RS23120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L01_RS23135	COG5001	Diguanylate cyclase
I6L01_RS23145	COG1349	DNA-binding transcription factor activity
I6L01_RS23155	COG0023	Translation Initiation Factor
I6L01_RS23165	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L01_RS23170	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6L01_RS23175	COG0671	phosphoesterase, PA-phosphatase related
I6L01_RS23185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L01_RS23205	COG0583	DNA-binding transcription factor activity
I6L01_RS23210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L01_RS23225	COG0616	signal peptide processing
I6L01_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
I6L01_RS23235	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6L01_RS23250	COG1187	pseudouridine synthase activity
I6L01_RS23255	COG4907	membrane protein (DUF2207)
I6L01_RS23260	COG0009	L-threonylcarbamoyladenylate synthase
I6L01_RS23265	COG0613	PHP domain protein
I6L01_RS23275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L01_RS23280	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L01_RS23280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L01_RS23285	COG0135	phosphoribosylanthranilate isomerase activity
I6L01_RS23285	COG0134	indole-3-glycerol-phosphate synthase activity
I6L01_RS23295	COG0159	tryptophan synthase activity
I6L01_RS23300	COG3729	General stress protein
I6L01_RS23305	COG3685	Protein conserved in bacteria
I6L01_RS23310	COG3685	Protein conserved in bacteria
I6L01_RS23315	COG3047	cAMP biosynthetic process
I6L01_RS23335	COG1607	acyl-coa hydrolase
I6L01_RS23345	COG2350	Protein conserved in bacteria
I6L01_RS23350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L01_RS23370	COG4608	Belongs to the ABC transporter superfamily
I6L01_RS23375	COG0444	Belongs to the ABC transporter superfamily
I6L01_RS23380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L01_RS23385	COG0601	transmembrane transport
I6L01_RS23390	COG4166	transmembrane transport
I6L01_RS23400	COG2095	MarC family integral membrane protein
I6L01_RS23405	COG1012	belongs to the aldehyde dehydrogenase family
I6L01_RS23405	COG1454	alcohol dehydrogenase
I6L01_RS23410	COG1435	thymidine kinase activity
I6L01_RS23420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L01_RS23425	COG0745	RESPONSE REGULATOR receiver
I6L01_RS23430	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L01_RS23440	COG0788	formyltetrahydrofolate deformylase activity
I6L01_RS23475	COG2181	nitrate reductase activity
I6L01_RS23480	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6L01_RS23485	COG1140	nitrate reductase beta subunit
I6L01_RS23490	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6L01_RS23495	COG2223	nitrite transmembrane transporter activity
I6L01_RS23500	COG3850	Histidine kinase
I6L01_RS23505	COG2197	response regulator
I6L01_RS23510	COG4932	domain protein
I6L01_RS23515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L01_RS23520	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6L01_RS23525	COG4572	Cation transport regulator
I6L01_RS23530	COG0387	Pfam Sodium calcium exchanger
I6L01_RS23555	COG2912	Transglutaminase-like superfamily
I6L01_RS23560	COG3094	Invasion gene expression up-regulator, SirB
I6L01_RS23565	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L01_RS23590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L01_RS23595	COG0659	secondary active sulfate transmembrane transporter activity
I6L01_RS23610	COG0012	GTP binding
I6L01_RS23615	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS23620	COG3284	Transcriptional regulator
I6L01_RS23625	COG2376	Dihydroxyacetone kinase
I6L01_RS23630	COG1461	Dihydroxyacetone kinase
I6L01_RS23635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L01_RS23635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L01_RS23635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6L01_RS23645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L01_RS23650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L01_RS23655	COG1120	ATPase activity
I6L01_RS23660	COG0500	methyltransferase
I6L01_RS23665	COG0157	Belongs to the NadC ModD family
I6L01_RS23680	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6L01_RS23690	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L01_RS23705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L01_RS23715	COG2719	SpoVR family
I6L01_RS23730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L01_RS23735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L01_RS23740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L01_RS23755	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L01_RS23785	COG2894	cell division
I6L01_RS23795	COG3468	outer membrane autotransporter barrel domain protein
I6L01_RS23835	COG2200	EAL domain
I6L01_RS23860	COG2200	EAL domain
I6L01_RS23865	COG0789	Transcriptional regulator
I6L01_RS23870	COG5562	phage envelope protein
I6L01_RS23895	COG0538	isocitrate dehydrogenase activity
I6L01_RS23910	COG1187	pseudouridine synthase activity
I6L01_RS23930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L01_RS23940	COG2205	protein histidine kinase activity
I6L01_RS23945	COG2850	peptidyl-arginine hydroxylation
I6L01_RS23955	COG3842	ATPase activity
I6L01_RS23970	COG0500	methyltransferase
I6L01_RS23975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6L01_RS24155	COG1475	DNA binding