locus-tag	class	description
I6L02_RS00030	COG2964	Protein conserved in bacteria
I6L02_RS00035	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L02_RS00045	COG1047	Peptidyl-prolyl cis-trans
I6L02_RS00050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L02_RS00065	COG0488	(ABC) transporter
I6L02_RS00070	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L02_RS00080	COG3954	Phosphoribulokinase
I6L02_RS00085	COG1765	OsmC-like protein
I6L02_RS00090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L02_RS00095	COG1289	transmembrane transporter activity
I6L02_RS00100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L02_RS00105	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L02_RS00110	COG2184	nucleotidyltransferase activity
I6L02_RS00120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L02_RS00130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L02_RS00135	COG2146	nitrite reductase [NAD(P)H] activity
I6L02_RS00140	COG2116	formate transmembrane transporter activity
I6L02_RS00155	COG0626	cystathionine gamma-synthase activity
I6L02_RS00170	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6L02_RS00175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L02_RS00180	COG3457	Alanine racemase
I6L02_RS00190	COG2188	Transcriptional regulator
I6L02_RS00195	COG0180	Tryptophanyl-tRNA synthetase
I6L02_RS00200	COG0546	phosphoglycolate phosphatase activity
I6L02_RS00205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L02_RS00210	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L02_RS00215	COG3266	domain, Protein
I6L02_RS00230	COG4796	Type ii and iii secretion system protein
I6L02_RS00245	COG3166	PFAM Fimbrial assembly family protein
I6L02_RS00250	COG4972	Pilus assembly protein
I6L02_RS00255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L02_RS00260	COG0494	nUDIX hydrolase
I6L02_RS00270	COG1011	Hydrolase
I6L02_RS00275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L02_RS00285	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6L02_RS00305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L02_RS00310	COG2183	response to ionizing radiation
I6L02_RS00315	COG1918	ferrous iron import across plasma membrane
I6L02_RS00320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6L02_RS00340	COG1040	competence protein
I6L02_RS00350	COG2610	gluconate transmembrane transporter activity
I6L02_RS00355	COG1640	4-alpha-glucanotransferase
I6L02_RS00360	COG0058	SHG alpha-glucan phosphorylase activity
I6L02_RS00375	COG1690	Belongs to the RtcB family
I6L02_RS00380	COG4650	regulator
I6L02_RS00385	COG1349	DNA-binding transcription factor activity
I6L02_RS00400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L02_RS00440	COG3188	usher protein
I6L02_RS00445	COG3121	Chaperone
I6L02_RS00455	COG0058	SHG alpha-glucan phosphorylase activity
I6L02_RS00480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L02_RS00485	COG2095	MarC family integral membrane protein
I6L02_RS00490	COG2610	gluconate transmembrane transporter activity
I6L02_RS00495	COG3265	gluconokinase activity
I6L02_RS00500	COG1609	Transcriptional regulator
I6L02_RS00505	COG1741	Belongs to the pirin family
I6L02_RS00510	COG0673	inositol 2-dehydrogenase activity
I6L02_RS00515	COG1247	-acetyltransferase
I6L02_RS00520	COG3157	Type VI secretion system effector, Hcp
I6L02_RS00540	COG0405	Gamma-glutamyltransferase
I6L02_RS00550	COG0584	glycerophosphoryl diester phosphodiesterase
I6L02_RS00575	COG0410	ABC transporter
I6L02_RS00580	COG0411	ABC transporter
I6L02_RS00585	COG4177	L-phenylalanine transmembrane transporter activity
I6L02_RS00590	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS00595	COG0683	leucine binding
I6L02_RS00600	COG0456	acetyltransferase
I6L02_RS00605	COG0683	leucine binding
I6L02_RS00610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L02_RS00615	COG2177	Part of the ABC transporter FtsEX involved in
I6L02_RS00620	COG2884	Cell division ATP-binding protein ftsE
I6L02_RS00625	COG0552	protein localization to endoplasmic reticulum
I6L02_RS00630	COG0742	ribosomal rna small subunit methyltransferase
I6L02_RS00635	COG3776	membrane
I6L02_RS00645	COG3714	YhhN family
I6L02_RS00660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L02_RS00670	COG0477	Major facilitator Superfamily
I6L02_RS00675	COG0628	permease
I6L02_RS00680	COG2091	lysine biosynthetic process via aminoadipic acid
I6L02_RS00685	COG0747	negative chemotaxis
I6L02_RS00690	COG0601	transmembrane transport
I6L02_RS00695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L02_RS00715	COG2188	Transcriptional regulator
I6L02_RS00725	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L02_RS00730	COG3775	system Galactitol-specific IIC component
I6L02_RS00745	COG0191	fructose-bisphosphate aldolase activity
I6L02_RS00750	COG0842	Transport permease protein
I6L02_RS00755	COG1129	ABC transporter
I6L02_RS00755	COG0842	Transport permease protein
I6L02_RS00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS00770	COG2081	HI0933 family
I6L02_RS00775	COG0306	phosphate transporter
I6L02_RS00785	COG0589	response to stress
I6L02_RS00790	COG3104	oligopeptide transport
I6L02_RS00800	COG0339	signal peptide processing
I6L02_RS00805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L02_RS00810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L02_RS00820	COG1393	Belongs to the ArsC family
I6L02_RS00830	COG3065	identical protein binding
I6L02_RS00835	COG2197	response regulator
I6L02_RS00840	COG3720	iron ion transport
I6L02_RS00845	COG4771	TonB-dependent receptor
I6L02_RS00860	COG3721	Heme iron utilization protein
I6L02_RS00870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS00880	COG1285	pathogenesis
I6L02_RS00895	COG3247	response to pH
I6L02_RS00900	COG2771	luxR family
I6L02_RS00910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS00915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L02_RS00920	COG2207	Transcriptional regulator
I6L02_RS00925	COG2207	Transcriptional regulator
I6L02_RS00930	COG0076	glutamate decarboxylase activity
I6L02_RS00935	COG1858	cytochrome C peroxidase
I6L02_RS00945	COG2197	response regulator
I6L02_RS00950	COG0583	DNA-binding transcription factor activity
I6L02_RS00955	COG1295	ribonuclease BN
I6L02_RS00960	COG0477	Major facilitator Superfamily
I6L02_RS00965	COG2982	Protein involved in outer membrane biogenesis
I6L02_RS00970	COG2200	EAL domain
I6L02_RS00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS00980	COG0612	Peptidase, M16
I6L02_RS00990	COG2199	diguanylate cyclase activity
I6L02_RS00990	COG2200	EAL domain
I6L02_RS00995	COG0457	Tetratricopeptide repeat
I6L02_RS00995	COG3118	belongs to the thioredoxin family
I6L02_RS01000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6L02_RS01005	COG1215	transferase activity, transferring glycosyl groups
I6L02_RS01010	COG1215	transferase activity, transferring glycosyl groups
I6L02_RS01035	COG2194	sulfuric ester hydrolase activity
I6L02_RS01045	COG0814	amino acid
I6L02_RS01050	COG4608	Belongs to the ABC transporter superfamily
I6L02_RS01055	COG0444	Belongs to the ABC transporter superfamily
I6L02_RS01060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L02_RS01065	COG0601	transmembrane transport
I6L02_RS01070	COG0747	negative chemotaxis
I6L02_RS01080	COG2194	sulfuric ester hydrolase activity
I6L02_RS01110	COG2223	nitrite transmembrane transporter activity
I6L02_RS01115	COG5571	outer membrane autotransporter
I6L02_RS01120	COG2818	Glycosylase
I6L02_RS01125	COG0456	acetyltransferase
I6L02_RS01130	COG0243	molybdopterin cofactor binding
I6L02_RS01135	COG2885	chlorophyll binding
I6L02_RS01150	COG2944	sequence-specific DNA binding
I6L02_RS01155	COG1278	Cold shock
I6L02_RS01180	COG3274	enterobacterial common antigen metabolic process
I6L02_RS01185	COG4682	membrane
I6L02_RS01190	COG4682	membrane
I6L02_RS01195	COG1070	Carbohydrate kinase
I6L02_RS01205	COG4213	ABC transporter substrate-binding protein
I6L02_RS01215	COG4214	carbohydrate transport
I6L02_RS01220	COG2207	Transcriptional regulator
I6L02_RS01220	COG1609	Transcriptional regulator
I6L02_RS01225	COG2992	FlgJ-related protein
I6L02_RS01230	COG0366	Alpha amylase catalytic
I6L02_RS01235	COG3977	Valine--pyruvate aminotransferase
I6L02_RS01240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS01245	COG1414	Transcriptional regulator
I6L02_RS01255	COG2731	YhcH YjgK YiaL family protein
I6L02_RS01265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6L02_RS01270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6L02_RS01275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6L02_RS01280	COG1070	Carbohydrate kinase
I6L02_RS01285	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6L02_RS01290	COG3623	hexulose-6-phosphate isomerase
I6L02_RS01295	COG0235	Class ii aldolase
I6L02_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS01310	COG1454	alcohol dehydrogenase
I6L02_RS01315	COG3276	selenocysteine insertion sequence binding
I6L02_RS01325	COG0625	glutathione transferase activity
I6L02_RS01330	COG1566	PFAM secretion protein HlyD family protein
I6L02_RS01340	COG2213	PTS system mannitol-specific
I6L02_RS01340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS01350	COG3722	fumarate hydratase activity
I6L02_RS01370	COG5295	Hep Hag repeat protein
I6L02_RS01375	COG1620	l-lactate permease
I6L02_RS01380	COG2186	Transcriptional regulator
I6L02_RS01390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L02_RS01395	COG1045	serine acetyltransferase
I6L02_RS01410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L02_RS01415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L02_RS01425	COG4942	peptidase
I6L02_RS01430	COG2861	carbohydrate metabolic process
I6L02_RS01435	COG1216	Glycosyl transferase, family 2
I6L02_RS01445	COG0156	8-amino-7-oxononanoate synthase activity
I6L02_RS01455	COG0859	PFAM glycosyl transferase family 9
I6L02_RS01460	COG0859	PFAM glycosyl transferase family 9
I6L02_RS01465	COG3307	-O-antigen
I6L02_RS01470	COG1216	Glycosyl transferase, family 2
I6L02_RS01475	COG1442	glycosyl transferase family 8
I6L02_RS01480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L02_RS01495	COG0515	serine threonine protein kinase
I6L02_RS01500	COG0438	transferase activity, transferring glycosyl groups
I6L02_RS01505	COG0859	PFAM glycosyl transferase family 9
I6L02_RS01510	COG1519	Transferase
I6L02_RS01540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L02_RS01565	COG1561	YicC-like family, N-terminal region
I6L02_RS01570	COG3645	SOS response
I6L02_RS01575	COG2860	membrane
I6L02_RS01585	COG0194	GDP metabolic process
I6L02_RS01595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L02_RS01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L02_RS01605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L02_RS01610	COG0786	glutamate:sodium symporter activity
I6L02_RS01615	COG2233	PERMEase
I6L02_RS01620	COG2982	Protein involved in outer membrane biogenesis
I6L02_RS01630	COG1940	carbohydrate kinase activity
I6L02_RS01635	COG0191	fructose-bisphosphate aldolase activity
I6L02_RS01645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS01645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS01650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS01655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS01655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS01655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS01660	COG3711	transcriptional antiterminator
I6L02_RS01665	COG1501	Belongs to the glycosyl hydrolase 31 family
I6L02_RS01670	COG2211	Major facilitator Superfamily
I6L02_RS01690	COG0697	spore germination
I6L02_RS01695	COG1464	Belongs to the NlpA lipoprotein family
I6L02_RS01715	COG2252	PERMEase
I6L02_RS01725	COG2271	Major facilitator Superfamily
I6L02_RS01730	COG2271	Major facilitator Superfamily
I6L02_RS01735	COG3851	Histidine kinase
I6L02_RS01740	COG2197	response regulator
I6L02_RS01750	COG0440	acetolactate synthase activity
I6L02_RS01755	COG0028	Belongs to the TPP enzyme family
I6L02_RS01765	COG2814	Major facilitator Superfamily
I6L02_RS01770	COG0641	radical SAM
I6L02_RS01780	COG2149	membrane
I6L02_RS01785	COG3119	arylsulfatase activity
I6L02_RS01790	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L02_RS01795	COG2207	Transcriptional regulator
I6L02_RS01815	COG5645	(Lipo)protein
I6L02_RS01820	COG0823	Involved in the tonB-independent uptake of proteins
I6L02_RS01830	COG2271	Major facilitator Superfamily
I6L02_RS01840	COG0800	Aldolase
I6L02_RS01845	COG3734	2-keto-3-deoxy-galactonokinase
I6L02_RS01850	COG2186	Transcriptional regulator
I6L02_RS01860	COG0561	phosphatase activity
I6L02_RS01865	COG3753	Protein conserved in bacteria
I6L02_RS01870	COG0187	DNA topoisomerase II activity
I6L02_RS01880	COG0592	DNA-directed DNA polymerase activity
I6L02_RS01930	COG0814	amino acid
I6L02_RS01940	COG0583	DNA-binding transcription factor activity
I6L02_RS01945	COG2091	lysine biosynthetic process via aminoadipic acid
I6L02_RS01950	COG0431	NADPH-dependent FMN reductase
I6L02_RS01955	COG2252	PERMEase
I6L02_RS01960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L02_RS01970	COG0363	glucosamine-6-phosphate deaminase activity
I6L02_RS01975	COG2382	esterase
I6L02_RS01980	COG4580	involved in the transport of maltose and maltodextrins
I6L02_RS01985	COG2723	6-phospho-beta-galactosidase activity
I6L02_RS01990	COG1263	PTS System
I6L02_RS01990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS01990	COG2190	(PTS) system
I6L02_RS01995	COG3711	transcriptional antiterminator
I6L02_RS02000	COG0704	Plays a role in the regulation of phosphate uptake
I6L02_RS02005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L02_RS02010	COG0581	inorganic phosphate transmembrane transporter activity
I6L02_RS02015	COG0573	inorganic phosphate transmembrane transporter activity
I6L02_RS02020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6L02_RS02030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L02_RS02075	COG3312	ion transport
I6L02_RS02090	COG0716	FMN binding
I6L02_RS02095	COG1522	sequence-specific DNA binding
I6L02_RS02125	COG1129	ABC transporter
I6L02_RS02130	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS02135	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS02140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS02145	COG1609	Transcriptional regulator
I6L02_RS02150	COG0477	Major facilitator Superfamily
I6L02_RS02155	COG2186	Transcriptional regulator
I6L02_RS02195	COG3085	chromosome segregation
I6L02_RS02200	COG0606	chelatase, subunit chli
I6L02_RS02220	COG3978	acetolactate synthase activity
I6L02_RS02225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L02_RS02235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L02_RS02240	COG0583	DNA-binding transcription factor activity
I6L02_RS02250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L02_RS02255	COG0210	DNA helicase
I6L02_RS02270	COG3118	belongs to the thioredoxin family
I6L02_RS02280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6L02_RS02285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L02_RS02290	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L02_RS02295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L02_RS02300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L02_RS02305	COG1088	dTDP-glucose 4,6-dehydratase activity
I6L02_RS02310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L02_RS02315	COG0456	acetyltransferase
I6L02_RS02320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L02_RS02325	COG2244	polysaccharide biosynthetic process
I6L02_RS02345	COG1113	amino acid transport
I6L02_RS02370	COG0641	radical SAM
I6L02_RS02375	COG3119	arylsulfatase activity
I6L02_RS02380	COG3071	HemY protein
I6L02_RS02385	COG2959	enzyme of heme biosynthesis
I6L02_RS02390	COG1587	Uroporphyrinogen-III synthase
I6L02_RS02395	COG0181	hydroxymethylbilane synthase activity
I6L02_RS02400	COG3072	Adenylate cyclase
I6L02_RS02415	COG5567	small periplasmic lipoprotein
I6L02_RS02425	COG3159	Protein conserved in bacteria
I6L02_RS02435	COG1011	Hydrolase
I6L02_RS02440	COG0210	DNA helicase
I6L02_RS02445	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L02_RS02450	COG3698	Phosphodiester glycosidase
I6L02_RS02455	COG0598	Magnesium transport protein CorA
I6L02_RS02470	COG2962	Rard protein
I6L02_RS02475	COG2050	protein possibly involved in aromatic compounds catabolism
I6L02_RS02480	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6L02_RS02485	COG0514	ATP-dependent DNA helicase (RecQ)
I6L02_RS02490	COG1280	lysine exporter protein (LysE YggA)
I6L02_RS02495	COG1280	lysine exporter protein (LysE YggA)
I6L02_RS02500	COG2267	carboxylic ester hydrolase activity
I6L02_RS02505	COG0561	phosphatase activity
I6L02_RS02510	COG0697	spore germination
I6L02_RS02515	COG0583	DNA-binding transcription factor activity
I6L02_RS02530	COG3157	Type VI secretion system effector, Hcp
I6L02_RS02540	COG2190	(PTS) system
I6L02_RS02540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS02540	COG1263	PTS System
I6L02_RS02545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L02_RS02550	COG1737	Transcriptional regulator
I6L02_RS02555	COG0583	DNA-binding transcription factor activity
I6L02_RS02560	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L02_RS02570	COG0549	Belongs to the carbamate kinase family
I6L02_RS02575	COG1304	FMN binding
I6L02_RS02580	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L02_RS02590	COG1335	isochorismatase
I6L02_RS02595	COG0412	Dienelactone hydrolase
I6L02_RS02600	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6L02_RS02620	COG0800	Aldolase
I6L02_RS02625	COG3734	2-keto-3-deoxy-galactonokinase
I6L02_RS02630	COG1414	Transcriptional regulator
I6L02_RS02635	COG1322	Protein conserved in bacteria
I6L02_RS02645	COG3165	ubiquinone biosynthetic process from chorismate
I6L02_RS02655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L02_RS02665	COG0805	protein transport
I6L02_RS02680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L02_RS02685	COG0543	2 iron, 2 sulfur cluster binding
I6L02_RS02705	COG1739	Uncharacterized protein family UPF0029
I6L02_RS02710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L02_RS02715	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L02_RS02745	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6L02_RS02750	COG0746	molybdenum cofactor guanylyltransferase activity
I6L02_RS02755	COG3084	Protein conserved in bacteria
I6L02_RS02760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L02_RS02765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L02_RS02770	COG5339	Protein conserved in bacteria
I6L02_RS02775	COG0204	Acyl-transferase
I6L02_RS02780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L02_RS02780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L02_RS02795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L02_RS02805	COG2204	response regulator
I6L02_RS02810	COG3852	Histidine kinase
I6L02_RS02815	COG0174	glutamine synthetase
I6L02_RS02820	COG1217	gtp-binding protein TYPA
I6L02_RS02825	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L02_RS02830	COG2211	Major facilitator Superfamily
I6L02_RS02835	COG2211	Major facilitator Superfamily
I6L02_RS02840	COG1501	Belongs to the glycosyl hydrolase 31 family
I6L02_RS02850	COG2017	converts alpha-aldose to the beta-anomer
I6L02_RS02855	COG2942	2-epimerase
I6L02_RS02860	COG3684	Belongs to the aldolase LacD family
I6L02_RS02865	COG2084	Dehydrogenase
I6L02_RS02870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS02875	COG1349	DNA-binding transcription factor activity
I6L02_RS02880	COG1011	Hydrolase
I6L02_RS02895	COG0456	acetyltransferase
I6L02_RS02905	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6L02_RS02930	COG2864	formate dehydrogenase
I6L02_RS02935	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS02995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L02_RS03005	COG2258	MOSC domain
I6L02_RS03010	COG2205	protein histidine kinase activity
I6L02_RS03015	COG0745	RESPONSE REGULATOR receiver
I6L02_RS03020	COG3678	ATP-independent chaperone mediated protein folding
I6L02_RS03035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L02_RS03055	COG3152	Membrane
I6L02_RS03060	COG3691	Protein conserved in bacteria
I6L02_RS03065	COG0589	response to stress
I6L02_RS03075	COG1494	fructose-1,6-bisphosphatase
I6L02_RS03085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L02_RS03100	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L02_RS03115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L02_RS03120	COG1609	Transcriptional regulator
I6L02_RS03125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L02_RS03135	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6L02_RS03145	COG0626	cystathionine gamma-synthase activity
I6L02_RS03150	COG0527	aspartate kinase activity
I6L02_RS03150	COG0460	homoserine dehydrogenase
I6L02_RS03160	COG0737	Belongs to the 5'-nucleotidase family
I6L02_RS03165	COG0737	Belongs to the 5'-nucleotidase family
I6L02_RS03175	COG0737	Belongs to the 5'-nucleotidase family
I6L02_RS03180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L02_RS03190	COG0697	spore germination
I6L02_RS03195	COG3738	Protein conserved in bacteria
I6L02_RS03200	COG0371	Dehydrogenase
I6L02_RS03205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L02_RS03210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS03210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS03210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L02_RS03215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS03220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS03225	COG1882	Formate acetyltransferase
I6L02_RS03230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L02_RS03235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS03240	COG2207	Transcriptional regulator
I6L02_RS03245	COG2194	sulfuric ester hydrolase activity
I6L02_RS03260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L02_RS03275	COG4948	Mandelate Racemase Muconate Lactonizing
I6L02_RS03280	COG2271	Major facilitator Superfamily
I6L02_RS03285	COG0583	DNA-binding transcription factor activity
I6L02_RS03295	COG1473	amidohydrolase
I6L02_RS03300	COG0477	Major facilitator Superfamily
I6L02_RS03350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L02_RS03355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6L02_RS03355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6L02_RS03390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L02_RS03395	COG0250	Participates in transcription elongation, termination and antitermination
I6L02_RS03430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L02_RS03440	COG2104	thiamine diphosphate biosynthetic process
I6L02_RS03445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L02_RS03450	COG0352	thiamine-phosphate diphosphorylase activity
I6L02_RS03460	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6L02_RS03480	COG3068	Protein conserved in bacteria
I6L02_RS03495	COG3678	ATP-independent chaperone mediated protein folding
I6L02_RS03500	COG4191	Histidine kinase
I6L02_RS03505	COG2204	response regulator
I6L02_RS03510	COG0151	Belongs to the GarS family
I6L02_RS03540	COG0456	acetyltransferase
I6L02_RS03550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L02_RS03555	COG2224	Isocitrate lyase
I6L02_RS03565	COG1414	Transcriptional regulator
I6L02_RS03585	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L02_RS03630	COG1187	pseudouridine synthase activity
I6L02_RS03640	COG0527	aspartate kinase activity
I6L02_RS03665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L02_RS03680	COG3833	ABC-type maltose transport systems, permease component
I6L02_RS03685	COG1175	transmembrane transport
I6L02_RS03690	COG2182	Extracellular solute-binding protein
I6L02_RS03695	COG3842	ATPase activity
I6L02_RS03725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L02_RS03735	COG0534	Mate efflux family protein
I6L02_RS03740	COG3237	CsbD-like
I6L02_RS03745	COG0735	belongs to the Fur family
I6L02_RS03750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L02_RS03760	COG0604	alcohol dehydrogenase
I6L02_RS03765	COG0305	Participates in initiation and elongation during chromosome replication
I6L02_RS03770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L02_RS03775	COG1448	Aminotransferase
I6L02_RS03780	COG0567	Dehydrogenase, E1 component
I6L02_RS03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L02_RS03795	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L02_RS03800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L02_RS03805	COG0471	metal ion transport
I6L02_RS03810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6L02_RS03815	COG2204	response regulator
I6L02_RS03825	COG3700	Belongs to the class B bacterial acid phosphatase family
I6L02_RS03830	COG0432	Pfam Uncharacterised protein family UPF0047
I6L02_RS03835	COG2315	Protein conserved in bacteria
I6L02_RS03840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L02_RS03845	COG0629	single-stranded DNA binding
I6L02_RS03855	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6L02_RS03860	COG2207	Transcriptional regulator
I6L02_RS03865	COG0789	Transcriptional regulator
I6L02_RS03870	COG2252	PERMEase
I6L02_RS03875	COG0025	NhaP-type Na H and K H
I6L02_RS03880	COG0583	DNA-binding transcription factor activity
I6L02_RS03885	COG1380	Effector of murein hydrolase LrgA
I6L02_RS03890	COG1346	cytolysis
I6L02_RS03900	COG3162	membrane
I6L02_RS03905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L02_RS03915	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L02_RS03920	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS03925	COG3301	Polysulphide reductase, NrfD
I6L02_RS03930	COG1138	Cytochrome C-type biogenesis protein
I6L02_RS03935	COG3088	subunit of a heme lyase
I6L02_RS03940	COG4235	cytochrome complex assembly
I6L02_RS03945	COG1301	dicarboxylic acid transport
I6L02_RS03950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L02_RS03955	COG4608	Belongs to the ABC transporter superfamily
I6L02_RS03960	COG0444	Belongs to the ABC transporter superfamily
I6L02_RS03965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L02_RS03970	COG0601	transmembrane transport
I6L02_RS03990	COG1289	transmembrane transporter activity
I6L02_RS03995	COG1566	PFAM secretion protein HlyD family protein
I6L02_RS04005	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L02_RS04010	COG1940	carbohydrate kinase activity
I6L02_RS04015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L02_RS04020	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS04025	COG1129	ABC transporter
I6L02_RS04030	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS04035	COG1737	Transcriptional regulator
I6L02_RS04040	COG0698	ribose 5-phosphate isomerase
I6L02_RS04050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6L02_RS04055	COG0456	acetyltransferase
I6L02_RS04065	COG3454	Phosphonate metabolism
I6L02_RS04070	COG4778	phosphonate C-P lyase system protein PhnL
I6L02_RS04075	COG4107	phosphonate C-P lyase system protein PhnK
I6L02_RS04080	COG3627	carbon phosphorus lyase activity
I6L02_RS04085	COG3626	phosphonate metabolism
I6L02_RS04090	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6L02_RS04095	COG3624	Phosphonate C-P lyase system protein PhnG
I6L02_RS04100	COG2188	Transcriptional regulator
I6L02_RS04105	COG3639	organic phosphonate transmembrane transporter activity
I6L02_RS04110	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6L02_RS04120	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6L02_RS04125	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L02_RS04140	COG0477	Major facilitator Superfamily
I6L02_RS04150	COG0642	Histidine kinase
I6L02_RS04155	COG0745	RESPONSE REGULATOR receiver
I6L02_RS04160	COG2194	sulfuric ester hydrolase activity
I6L02_RS04165	COG0531	amino acid
I6L02_RS04170	COG2207	Transcriptional regulator
I6L02_RS04175	COG1982	Orn Lys Arg decarboxylase major
I6L02_RS04180	COG2169	Transcriptional regulator
I6L02_RS04185	COG1486	melibiose metabolic process
I6L02_RS04190	COG3647	Membrane
I6L02_RS04195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L02_RS04195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L02_RS04200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L02_RS04205	COG4565	transcriptional regulatory protein
I6L02_RS04210	COG3290	protein histidine kinase activity
I6L02_RS04215	COG3592	Divergent 4Fe-4S mono-cluster
I6L02_RS04220	COG2388	GCN5-related N-acetyl-transferase
I6L02_RS04235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L02_RS04240	COG3104	oligopeptide transport
I6L02_RS04245	COG1982	Orn Lys Arg decarboxylase major
I6L02_RS04250	COG0531	amino acid
I6L02_RS04255	COG3710	Transcriptional regulator
I6L02_RS04265	COG1309	transcriptional regulator
I6L02_RS04280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L02_RS04285	COG1027	Aspartate ammonia-lyase
I6L02_RS04290	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L02_RS04295	COG0531	amino acid
I6L02_RS04320	COG1509	lysine 2,3-aminomutase activity
I6L02_RS04330	COG5510	response to toxic substance
I6L02_RS04335	COG5510	response to toxic substance
I6L02_RS04340	COG2076	Multidrug Resistance protein
I6L02_RS04345	COG3040	lipid binding
I6L02_RS04350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L02_RS04365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L02_RS04370	COG1053	succinate dehydrogenase
I6L02_RS04380	COG0531	amino acid
I6L02_RS04385	COG3264	Mechanosensitive ion channel
I6L02_RS04385	COG1511	domain protein
I6L02_RS04430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L02_RS04435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L02_RS04435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L02_RS04440	COG0802	atpase or kinase
I6L02_RS04445	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L02_RS04450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L02_RS04465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L02_RS04470	COG0330	HflC and HflK could
I6L02_RS04475	COG0330	HflC and HflK could
I6L02_RS04480	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L02_RS04495	COG0557	exoribonuclease II activity
I6L02_RS04500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L02_RS04505	COG3789	protein conserved in bacteria
I6L02_RS04510	COG1842	Phage shock protein A
I6L02_RS04520	COG3766	membrane
I6L02_RS04525	COG5463	Belongs to the UPF0441 family
I6L02_RS04530	COG0754	glutathionylspermidine amidase activity
I6L02_RS04535	COG1960	acyl-CoA dehydrogenase activity
I6L02_RS04545	COG3650	response to hydrogen peroxide
I6L02_RS04550	COG1073	alpha beta
I6L02_RS04565	COG3037	sugar-specific permease SgaT UlaA
I6L02_RS04575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS04590	COG0235	Class ii aldolase
I6L02_RS04610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L02_RS04630	COG2271	Major facilitator Superfamily
I6L02_RS04640	COG4670	ketone body catabolic process
I6L02_RS04645	COG1024	Enoyl-CoA hydratase
I6L02_RS04660	COG1309	transcriptional regulator
I6L02_RS04665	COG3061	Opacity-associated protein A
I6L02_RS04670	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L02_RS04675	COG1113	amino acid transport
I6L02_RS04685	COG0697	spore germination
I6L02_RS04690	COG0702	epimerase
I6L02_RS04695	COG1733	regulation of RNA biosynthetic process
I6L02_RS04700	COG0737	Belongs to the 5'-nucleotidase family
I6L02_RS04705	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L02_RS04710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L02_RS04720	COG1253	flavin adenine dinucleotide binding
I6L02_RS04730	COG0729	surface antigen
I6L02_RS04735	COG2911	Protein conserved in bacteria
I6L02_RS04740	COG2105	PFAM AIG2 family protein
I6L02_RS04745	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L02_RS04750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L02_RS04755	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS04760	COG1129	ABC transporter
I6L02_RS04765	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS04770	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS04780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L02_RS04790	COG0312	modulator of DNA gyrase
I6L02_RS04795	COG3783	Cytochrome b(562)
I6L02_RS04800	COG3077	Addiction module antitoxin, RelB DinJ family
I6L02_RS04805	COG2026	Addiction module toxin, RelE StbE family
I6L02_RS04810	COG0602	queuosine metabolic process
I6L02_RS04815	COG1328	CTP reductase activity
I6L02_RS04820	COG0366	Alpha amylase catalytic
I6L02_RS04825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS04825	COG1263	PTS System
I6L02_RS04830	COG1609	Transcriptional regulator
I6L02_RS04840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6L02_RS04845	COG0251	oxidation-reduction process
I6L02_RS04865	COG1438	arginine binding
I6L02_RS04870	COG1288	antiporter activity
I6L02_RS04875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L02_RS04880	COG0549	Belongs to the carbamate kinase family
I6L02_RS04890	COG2731	YhcH YjgK YiaL family protein
I6L02_RS04895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L02_RS04900	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L02_RS04905	COG0456	acetyltransferase
I6L02_RS04915	COG0525	valine-tRNA ligase activity
I6L02_RS04920	COG2927	DNA polymerase III (CHI subunit)
I6L02_RS04930	COG0795	lipopolysaccharide-transporting ATPase activity
I6L02_RS04935	COG0795	lipopolysaccharide-transporting ATPase activity
I6L02_RS04940	COG0433	COG0433 Predicted ATPase
I6L02_RS04945	COG1609	Transcriptional regulator
I6L02_RS04950	COG2610	gluconate transmembrane transporter activity
I6L02_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS04960	COG1063	alcohol dehydrogenase
I6L02_RS04965	COG3265	gluconokinase activity
I6L02_RS04970	COG1064	alcohol dehydrogenase
I6L02_RS05015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L02_RS05020	COG0582	viral genome integration into host DNA
I6L02_RS05025	COG4974	Belongs to the 'phage' integrase family
I6L02_RS05030	COG3539	Fimbrial protein
I6L02_RS05035	COG3539	Fimbrial protein
I6L02_RS05040	COG3121	Chaperone
I6L02_RS05045	COG3188	usher protein
I6L02_RS05050	COG3539	Fimbrial protein
I6L02_RS05055	COG3539	Fimbrial protein
I6L02_RS05060	COG3539	Fimbrial protein
I6L02_RS05075	COG0246	Mannitol dehydrogenase
I6L02_RS05080	COG2186	Transcriptional regulator
I6L02_RS05085	COG3518	anti-sigma factor antagonist activity
I6L02_RS05090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L02_RS05090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS05095	COG1461	Dihydroxyacetone kinase
I6L02_RS05100	COG2376	Dihydroxyacetone kinase
I6L02_RS05115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L02_RS05125	COG1929	Belongs to the glycerate kinase type-1 family
I6L02_RS05130	COG2084	Dehydrogenase
I6L02_RS05135	COG3622	Belongs to the hyi family
I6L02_RS05140	COG3960	tartronate-semialdehyde synthase activity
I6L02_RS05145	COG3284	Transcriptional regulator
I6L02_RS05155	COG1757	Na H antiporter
I6L02_RS05160	COG0583	DNA-binding transcription factor activity
I6L02_RS05165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L02_RS05170	COG0700	Nucleoside recognition
I6L02_RS05175	COG3366	ferrous iron transmembrane transporter activity
I6L02_RS05185	COG0477	Major facilitator Superfamily
I6L02_RS05200	COG1924	4 iron, 4 sulfur cluster binding
I6L02_RS05205	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6L02_RS05210	COG2733	membrane
I6L02_RS05220	COG5457	Domain of unknown function (DUF1127)
I6L02_RS05235	COG0732	type I restriction modification DNA specificity domain
I6L02_RS05255	COG0523	cobalamin synthesis protein
I6L02_RS05260	COG2879	small protein
I6L02_RS05265	COG1966	Carbon starvation protein
I6L02_RS05270	COG0840	transmembrane signaling receptor activity
I6L02_RS05275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6L02_RS05285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6L02_RS05290	COG0025	NhaP-type Na H and K H
I6L02_RS05295	COG1802	Transcriptional regulator
I6L02_RS05300	COG1063	alcohol dehydrogenase
I6L02_RS05315	COG1484	DNA-dependent DNA replication
I6L02_RS05330	COG2966	Psort location CytoplasmicMembrane, score
I6L02_RS05335	COG2197	response regulator
I6L02_RS05340	COG2197	response regulator
I6L02_RS05345	COG4114	ferric iron reductase
I6L02_RS05375	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6L02_RS05380	COG0456	acetyltransferase
I6L02_RS05385	COG1011	Hydrolase
I6L02_RS05395	COG2823	Periplasmic or secreted lipoprotein
I6L02_RS05405	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L02_RS05410	COG0084	hydrolase, TatD family'
I6L02_RS05415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L02_RS05420	COG1328	CTP reductase activity
I6L02_RS05455	COG3726	membrane protein affecting hemolysin expression
I6L02_RS05460	COG0560	Phosphoserine phosphatase
I6L02_RS05465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L02_RS05470	COG1056	cytidyltransferase-related domain
I6L02_RS05470	COG3172	ATPase kinase involved in NAD metabolism
I6L02_RS05475	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6L02_RS05485	COG0488	(ABC) transporter
I6L02_RS05490	COG0741	lytic transglycosylase activity
I6L02_RS05510	COG3708	Transcriptional regulator
I6L02_RS05510	COG2207	Transcriptional regulator
I6L02_RS05515	COG3045	CreA protein
I6L02_RS05520	COG0745	RESPONSE REGULATOR receiver
I6L02_RS05525	COG2205	protein histidine kinase activity
I6L02_RS05530	COG4452	Inner membrane protein CreD
I6L02_RS05535	COG0745	RESPONSE REGULATOR receiver
I6L02_RS05545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L02_RS05555	COG0527	aspartate kinase activity
I6L02_RS05555	COG0460	homoserine dehydrogenase
I6L02_RS05565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L02_RS05580	COG1115	amino acid carrier protein
I6L02_RS05590	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L02_RS05595	COG1584	GPR1 FUN34 yaaH family protein
I6L02_RS05600	COG4735	regulation of single-species biofilm formation
I6L02_RS05630	COG3119	arylsulfatase activity
I6L02_RS05645	COG0583	DNA-binding transcription factor activity
I6L02_RS05660	COG0196	riboflavin kinase activity
I6L02_RS05675	COG1047	Peptidyl-prolyl cis-trans
I6L02_RS05700	COG0505	Belongs to the CarA family
I6L02_RS05705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L02_RS05755	COG0644	oxidoreductase
I6L02_RS05760	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L02_RS05765	COG2271	Major facilitator Superfamily
I6L02_RS05780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6L02_RS05810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L02_RS05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L02_RS05825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L02_RS05830	COG0564	pseudouridine synthase activity
I6L02_RS05840	COG0417	DNA replication proofreading
I6L02_RS05845	COG0235	Class ii aldolase
I6L02_RS05860	COG4977	sequence-specific DNA binding
I6L02_RS05875	COG0586	Pfam SNARE associated Golgi protein
I6L02_RS05885	COG1178	ABC-type Fe3 transport system permease component
I6L02_RS05890	COG4143	(ABC) transporter
I6L02_RS05915	COG0473	3-isopropylmalate dehydrogenase activity
I6L02_RS05930	COG0583	DNA-binding transcription factor activity
I6L02_RS05940	COG0028	Belongs to the TPP enzyme family
I6L02_RS05945	COG0440	acetolactate synthase activity
I6L02_RS05955	COG1609	Transcriptional regulator
I6L02_RS05970	COG3116	cell division
I6L02_RS05975	COG0768	penicillin binding
I6L02_RS05980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L02_RS05985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L02_RS05995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L02_RS06000	COG0772	Belongs to the SEDS family
I6L02_RS06015	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L02_RS06020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L02_RS06025	COG0849	cell division
I6L02_RS06030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L02_RS06050	COG0494	nUDIX hydrolase
I6L02_RS06065	COG0237	dephospho-CoA kinase activity
I6L02_RS06080	COG1459	type II secretion system
I6L02_RS06085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L02_RS06090	COG4969	Belongs to the N-Me-Phe pilin family
I6L02_RS06095	COG0157	Belongs to the NadC ModD family
I6L02_RS06100	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L02_RS06105	COG3725	Membrane protein required for beta-lactamase induction
I6L02_RS06110	COG1113	amino acid transport
I6L02_RS06115	COG3157	Type VI secretion system effector, Hcp
I6L02_RS06145	COG2186	Transcriptional regulator
I6L02_RS06150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L02_RS06155	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L02_RS06160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L02_RS06165	COG3064	Membrane
I6L02_RS06170	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L02_RS06195	COG2132	Multicopper oxidase
I6L02_RS06200	COG4993	Dehydrogenase
I6L02_RS06205	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6L02_RS06210	COG0288	reversible hydration of carbon dioxide
I6L02_RS06215	COG1131	(ABC) transporter
I6L02_RS06220	COG0842	Transport permease protein
I6L02_RS06225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS06230	COG0726	polysaccharide deacetylase
I6L02_RS06240	COG5464	transposase or invertase
I6L02_RS06250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L02_RS06260	COG3539	Fimbrial protein
I6L02_RS06265	COG3539	Fimbrial protein
I6L02_RS06270	COG3539	Fimbrial protein
I6L02_RS06275	COG3539	Fimbrial protein
I6L02_RS06280	COG3188	usher protein
I6L02_RS06285	COG3121	Chaperone
I6L02_RS06290	COG3539	Fimbrial protein
I6L02_RS06295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L02_RS06300	COG0617	tRNA 3'-terminal CCA addition
I6L02_RS06305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L02_RS06310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L02_RS06320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6L02_RS06325	COG1643	Atp-dependent helicase
I6L02_RS06330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L02_RS06335	COG4774	siderophore transport
I6L02_RS06340	COG1120	ATPase activity
I6L02_RS06345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L02_RS06350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS06375	COG2860	membrane
I6L02_RS06380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L02_RS06395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L02_RS06400	COG3835	regulator
I6L02_RS06420	COG0024	Methionine aminopeptidase
I6L02_RS06445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L02_RS06450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L02_RS06455	COG0575	Belongs to the CDS family
I6L02_RS06460	COG0750	zinc metalloprotease
I6L02_RS06470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6L02_RS06500	COG0587	DNA-directed DNA polymerase activity
I6L02_RS06510	COG1982	Orn Lys Arg decarboxylase major
I6L02_RS06515	COG0346	lactoylglutathione lyase activity
I6L02_RS06520	COG0037	tRNA processing
I6L02_RS06525	COG4568	rho-dependent transcription termination
I6L02_RS06535	COG4681	YaeQ
I6L02_RS06540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6L02_RS06545	COG3015	lipoprotein NlpE involved in copper resistance
I6L02_RS06550	COG0791	NLP P60 protein
I6L02_RS06570	COG1464	Belongs to the NlpA lipoprotein family
I6L02_RS06575	COG2011	ABC-type metal ion transport system permease component
I6L02_RS06585	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L02_RS06620	COG0656	L-ascorbic acid biosynthetic process
I6L02_RS06625	COG0583	DNA-binding transcription factor activity
I6L02_RS06635	COG2226	methyltransferase
I6L02_RS06640	COG1388	LysM domain
I6L02_RS06640	COG0741	lytic transglycosylase activity
I6L02_RS06650	COG2226	methyltransferase
I6L02_RS06660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L02_RS06755	COG3501	Rhs element vgr protein
I6L02_RS06790	COG5433	transposase activity
I6L02_RS06810	COG3501	Rhs element vgr protein
I6L02_RS06850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L02_RS06860	COG1960	acyl-CoA dehydrogenase activity
I6L02_RS06870	COG0121	glutamine amidotransferase
I6L02_RS06875	COG3034	peptidoglycan biosynthetic process
I6L02_RS06880	COG0791	NLP P60 protein
I6L02_RS06885	COG1943	Transposase
I6L02_RS06905	COG2161	toxin-antitoxin pair type II binding
I6L02_RS06915	COG0454	-acetyltransferase
I6L02_RS06920	COG1690	Belongs to the RtcB family
I6L02_RS06925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6L02_RS06930	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L02_RS06950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L02_RS06970	COG0582	viral genome integration into host DNA
I6L02_RS07000	COG3477	response to acidic pH
I6L02_RS07010	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6L02_RS07025	COG3188	usher protein
I6L02_RS07065	COG1902	pentaerythritol trinitrate reductase activity
I6L02_RS07070	COG1073	alpha beta
I6L02_RS07075	COG0583	DNA-binding transcription factor activity
I6L02_RS07085	COG0667	Aldo Keto reductase
I6L02_RS07090	COG0656	L-ascorbic acid biosynthetic process
I6L02_RS07095	COG1388	LysM domain
I6L02_RS07100	COG3708	Transcriptional regulator
I6L02_RS07100	COG2207	Transcriptional regulator
I6L02_RS07105	COG0656	L-ascorbic acid biosynthetic process
I6L02_RS07110	COG3059	membrane
I6L02_RS07120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L02_RS07125	COG2207	Transcriptional regulator
I6L02_RS07130	COG0247	lactate metabolic process
I6L02_RS07135	COG1139	Iron-sulfur cluster binding protein
I6L02_RS07140	COG1556	Lactate utilization protein
I6L02_RS07150	COG3468	outer membrane autotransporter barrel domain protein
I6L02_RS07165	COG2200	EAL domain
I6L02_RS07165	COG2771	luxR family
I6L02_RS07170	COG0582	viral genome integration into host DNA
I6L02_RS07190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6L02_RS07195	COG2771	luxR family
I6L02_RS07195	COG2200	EAL domain
I6L02_RS07200	COG0583	DNA-binding transcription factor activity
I6L02_RS07210	COG0666	response to abiotic stimulus
I6L02_RS07220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L02_RS07225	COG1304	FMN binding
I6L02_RS07230	COG0549	Belongs to the carbamate kinase family
I6L02_RS07235	COG0402	S-adenosylhomocysteine deaminase activity
I6L02_RS07240	COG1064	alcohol dehydrogenase
I6L02_RS07250	COG1280	lysine exporter protein (LysE YggA)
I6L02_RS07260	COG3829	transcription factor binding
I6L02_RS07265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L02_RS07270	COG0372	Belongs to the citrate synthase family
I6L02_RS07275	COG2079	MmgE PrpD family protein
I6L02_RS07280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L02_RS07285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L02_RS07290	COG0402	S-adenosylhomocysteine deaminase activity
I6L02_RS07295	COG0110	maltose O-acetyltransferase activity
I6L02_RS07300	COG2223	nitrite transmembrane transporter activity
I6L02_RS07310	COG1609	Transcriptional regulator
I6L02_RS07320	COG3122	Protein conserved in bacteria
I6L02_RS07325	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6L02_RS07350	COG1215	transferase activity, transferring glycosyl groups
I6L02_RS07355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6L02_RS07360	COG4521	taurine ABC transporter
I6L02_RS07365	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6L02_RS07370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L02_RS07375	COG2175	clavaminate synthase activity
I6L02_RS07380	COG0113	porphobilinogen synthase activity
I6L02_RS07385	COG3468	outer membrane autotransporter barrel domain protein
I6L02_RS07390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L02_RS07395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L02_RS07400	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6L02_RS07420	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L02_RS07435	COG1785	Belongs to the alkaline phosphatase family
I6L02_RS07445	COG3706	GGDEF domain
I6L02_RS07450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L02_RS07470	COG4126	flavin adenine dinucleotide binding
I6L02_RS07495	COG1940	carbohydrate kinase activity
I6L02_RS07500	COG2814	Major facilitator Superfamily
I6L02_RS07505	COG0419	ATPase involved in DNA repair
I6L02_RS07510	COG0420	3'-5' exonuclease activity
I6L02_RS07515	COG0745	RESPONSE REGULATOR receiver
I6L02_RS07520	COG5002	protein histidine kinase activity
I6L02_RS07525	COG1114	Component of the transport system for branched-chain amino acids
I6L02_RS07530	COG1113	amino acid transport
I6L02_RS07535	COG0366	Alpha amylase catalytic
I6L02_RS07540	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6L02_RS07555	COG1862	Preprotein translocase
I6L02_RS07560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L02_RS07565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L02_RS07570	COG1403	HNH endonuclease
I6L02_RS07575	COG3248	Nucleoside-binding outer membrane protein
I6L02_RS07580	COG4238	major outer membrane lipoprotein
I6L02_RS07590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L02_RS07590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L02_RS07605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L02_RS07610	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L02_RS07615	COG0667	Aldo Keto reductase
I6L02_RS07625	COG0142	geranyltranstransferase activity
I6L02_RS07640	COG0693	protein deglycase activity
I6L02_RS07645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L02_RS07665	COG2814	Major facilitator Superfamily
I6L02_RS07675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L02_RS07680	COG1845	cytochrome c oxidase, subunit III
I6L02_RS07685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L02_RS07690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L02_RS07695	COG2223	nitrite transmembrane transporter activity
I6L02_RS07700	COG3056	Lipoprotein
I6L02_RS07705	COG0271	Belongs to the BolA IbaG family
I6L02_RS07725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L02_RS07730	COG0776	regulation of translation
I6L02_RS07735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L02_RS07740	COG1555	photosystem II stabilization
I6L02_RS07745	COG0824	Thioesterase
I6L02_RS07755	COG4533	DNA binding
I6L02_RS07765	COG1522	sequence-specific DNA binding
I6L02_RS07770	COG1132	(ABC) transporter
I6L02_RS07775	COG1132	(ABC) transporter
I6L02_RS07780	COG0347	Belongs to the P(II) protein family
I6L02_RS07785	COG0004	ammonium transporteR
I6L02_RS07790	COG1946	Acyl-CoA thioesterase
I6L02_RS07795	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6L02_RS07800	COG3695	enzyme binding
I6L02_RS07810	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6L02_RS07815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6L02_RS07825	COG0110	maltose O-acetyltransferase activity
I6L02_RS07840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L02_RS07845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS07850	COG1309	transcriptional regulator
I6L02_RS07855	COG1196	nuclear chromosome segregation
I6L02_RS07855	COG3264	Mechanosensitive ion channel
I6L02_RS07865	COG3923	Primosomal replication protein n
I6L02_RS07870	COG2832	Protein of unknown function (DUF454)
I6L02_RS07880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L02_RS07915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS07920	COG4651	solute:proton antiporter activity
I6L02_RS07920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L02_RS07925	COG2223	nitrite transmembrane transporter activity
I6L02_RS07930	COG0737	Belongs to the 5'-nucleotidase family
I6L02_RS07945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L02_RS07950	COG3735	TraB family
I6L02_RS07955	COG3549	Plasmid maintenance system killer
I6L02_RS07960	COG3093	addiction module antidote protein HigA
I6L02_RS07965	COG2217	Heavy metal translocating P-type atpase
I6L02_RS07970	COG2066	Belongs to the glutaminase family
I6L02_RS07975	COG0531	amino acid
I6L02_RS07980	COG0789	Transcriptional regulator
I6L02_RS07990	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L02_RS07995	COG0330	HflC and HflK could
I6L02_RS08000	COG4619	ABC transporter
I6L02_RS08005	COG0390	transport system, permease component
I6L02_RS08010	COG3118	belongs to the thioredoxin family
I6L02_RS08015	COG0300	oxidoreductase activity
I6L02_RS08020	COG2755	lipolytic protein G-D-S-L family
I6L02_RS08025	COG4181	ATPase activity
I6L02_RS08030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L02_RS08050	COG1414	Transcriptional regulator
I6L02_RS08055	COG3960	tartronate-semialdehyde synthase activity
I6L02_RS08060	COG3622	Belongs to the hyi family
I6L02_RS08065	COG2084	Dehydrogenase
I6L02_RS08070	COG1953	Uracil, thiamine, allantoin
I6L02_RS08080	COG2233	PERMEase
I6L02_RS08085	COG1929	Belongs to the glycerate kinase type-1 family
I6L02_RS08090	COG3257	ureidoglycine aminohydrolase activity
I6L02_RS08095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L02_RS08100	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6L02_RS08105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L02_RS08110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L02_RS08120	COG0549	Belongs to the carbamate kinase family
I6L02_RS08125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L02_RS08130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L02_RS08140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L02_RS08145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L02_RS08155	COG1988	membrane-bound metal-dependent
I6L02_RS08160	COG2501	S4 domain
I6L02_RS08190	COG0500	methyltransferase
I6L02_RS08195	COG4571	Outer membrane protease
I6L02_RS08205	COG4783	chaperone-mediated protein folding
I6L02_RS08210	COG1215	transferase activity, transferring glycosyl groups
I6L02_RS08215	COG5002	protein histidine kinase activity
I6L02_RS08220	COG0745	RESPONSE REGULATOR receiver
I6L02_RS08225	COG1538	Outer membrane efflux protein
I6L02_RS08230	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS08235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS08240	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L02_RS08245	COG1113	amino acid transport
I6L02_RS08250	COG0668	transmembrane transport
I6L02_RS08255	COG0778	Nitroreductase
I6L02_RS08260	COG2315	Protein conserved in bacteria
I6L02_RS08270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6L02_RS08280	COG2977	Belongs to the P-Pant transferase superfamily
I6L02_RS08285	COG4771	TonB-dependent receptor
I6L02_RS08295	COG2382	esterase
I6L02_RS08300	COG3251	PFAM MbtH domain protein
I6L02_RS08305	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L02_RS08305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L02_RS08310	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L02_RS08315	COG1120	ATPase activity
I6L02_RS08320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS08325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS08335	COG4592	Periplasmic binding protein
I6L02_RS08340	COG1169	isochorismate synthase
I6L02_RS08345	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L02_RS08350	COG3433	isochorismatase activity
I6L02_RS08350	COG1535	isochorismatase
I6L02_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS08360	COG2050	protein possibly involved in aromatic compounds catabolism
I6L02_RS08365	COG1966	Carbon starvation protein
I6L02_RS08370	COG2879	small protein
I6L02_RS08375	COG0371	Dehydrogenase
I6L02_RS08380	COG0436	Aminotransferase
I6L02_RS08385	COG1475	DNA binding
I6L02_RS08390	COG3969	phosphoadenosine phosphosulfate
I6L02_RS08395	COG0583	DNA-binding transcription factor activity
I6L02_RS08400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L02_RS08405	COG0450	alkyl hydroperoxide reductase
I6L02_RS08410	COG3634	alkyl hydroperoxide reductase activity
I6L02_RS08415	COG0589	response to stress
I6L02_RS08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L02_RS08425	COG3719	Belongs to the RNase T2 family
I6L02_RS08430	COG0471	metal ion transport
I6L02_RS08445	COG3051	citrate lyase alpha subunit
I6L02_RS08450	COG2301	Belongs to the HpcH HpaI aldolase family
I6L02_RS08460	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6L02_RS08465	COG3290	protein histidine kinase activity
I6L02_RS08470	COG4565	transcriptional regulatory protein
I6L02_RS08475	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L02_RS08495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L02_RS08500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L02_RS08525	COG1686	Belongs to the peptidase S11 family
I6L02_RS08530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L02_RS08535	COG0772	Belongs to the SEDS family
I6L02_RS08540	COG0768	penicillin binding
I6L02_RS08550	COG0799	negative regulation of ribosome biogenesis
I6L02_RS08555	COG0406	alpha-ribazole phosphatase activity
I6L02_RS08565	COG1466	dna polymerase III delta subunit
I6L02_RS08580	COG2888	peptidyl-tyrosine sulfation
I6L02_RS08590	COG1126	abc transporter atp-binding protein
I6L02_RS08595	COG0765	amino acid transport
I6L02_RS08600	COG0765	amino acid transport
I6L02_RS08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS08615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L02_RS08620	COG4535	Mg2 and Co2 transporter CorC
I6L02_RS08630	COG1702	phosphate starvation-inducible protein PhoH
I6L02_RS08640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L02_RS08680	COG0367	asparagine synthase
I6L02_RS08685	COG0647	UMP catabolic process
I6L02_RS08690	COG1846	Transcriptional regulator
I6L02_RS08690	COG1940	carbohydrate kinase activity
I6L02_RS08695	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L02_RS08705	COG2190	(PTS) system
I6L02_RS08705	COG1263	PTS System
I6L02_RS08705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS08725	COG0861	Integral membrane protein TerC family
I6L02_RS08730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L02_RS08735	COG1454	alcohol dehydrogenase
I6L02_RS08740	COG3395	kinase activity
I6L02_RS08745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L02_RS08750	COG1349	DNA-binding transcription factor activity
I6L02_RS08770	COG0735	belongs to the Fur family
I6L02_RS08780	COG0716	FMN binding
I6L02_RS08790	COG0596	Alpha beta hydrolase
I6L02_RS08795	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L02_RS08800	COG0033	Phosphoglucomutase
I6L02_RS08805	COG0531	amino acid
I6L02_RS08810	COG1982	Orn Lys Arg decarboxylase major
I6L02_RS08820	COG0745	RESPONSE REGULATOR receiver
I6L02_RS08825	COG2205	protein histidine kinase activity
I6L02_RS08855	COG3272	Protein of unknown function (DUF1722)
I6L02_RS08860	COG0415	Belongs to the DNA photolyase family
I6L02_RS08870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L02_RS08875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6L02_RS08880	COG1984	allophanate hydrolase subunit 2
I6L02_RS08885	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6L02_RS08895	COG3180	Ammonia monooxygenase
I6L02_RS08900	COG3539	Fimbrial protein
I6L02_RS08905	COG0372	Belongs to the citrate synthase family
I6L02_RS08915	COG2009	succinate dehydrogenase
I6L02_RS08920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L02_RS08925	COG1053	succinate dehydrogenase
I6L02_RS08930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L02_RS08935	COG0567	Dehydrogenase, E1 component
I6L02_RS08940	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L02_RS08950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L02_RS08960	COG1271	oxidase subunit
I6L02_RS08965	COG1294	oxidase, subunit
I6L02_RS08970	COG4890	Cyd operon protein YbgT
I6L02_RS08975	COG3790	cyd operon protein YbgE
I6L02_RS08980	COG0824	Thioesterase
I6L02_RS08985	COG0811	peptide transport
I6L02_RS08990	COG0848	biopolymer transport protein
I6L02_RS08995	COG3064	Membrane
I6L02_RS09005	COG2885	chlorophyll binding
I6L02_RS09010	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L02_RS09050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L02_RS09055	COG3201	nicotinamide mononucleotide transporter
I6L02_RS09060	COG1230	cation diffusion facilitator family transporter
I6L02_RS09070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L02_RS09080	COG2017	converts alpha-aldose to the beta-anomer
I6L02_RS09090	COG1085	galactose-1-phosphate uridylyltransferase
I6L02_RS09095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L02_RS09100	COG1119	ATPase activity
I6L02_RS09105	COG2005	Transcriptional regulator
I6L02_RS09105	COG3585	molybdate ion transport
I6L02_RS09115	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6L02_RS09120	COG4149	molybdate abc transporter
I6L02_RS09125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L02_RS09130	COG0561	phosphatase activity
I6L02_RS09140	COG0583	DNA-binding transcription factor activity
I6L02_RS09145	COG2828	Protein conserved in bacteria
I6L02_RS09150	COG0471	metal ion transport
I6L02_RS09155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L02_RS09160	COG4677	pectinesterase activity
I6L02_RS09165	COG1881	PFAM PEBP family protein
I6L02_RS09175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L02_RS09190	COG2226	methyltransferase
I6L02_RS09195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L02_RS09205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6L02_RS09215	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L02_RS09225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L02_RS09230	COG0314	molybdopterin synthase activity
I6L02_RS09235	COG0670	Belongs to the BI1 family
I6L02_RS09240	COG0670	Belongs to the BI1 family
I6L02_RS09245	COG0392	lysyltransferase activity
I6L02_RS09250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L02_RS09255	COG3568	Endonuclease Exonuclease Phosphatase
I6L02_RS09265	COG0842	Transport permease protein
I6L02_RS09270	COG0842	Transport permease protein
I6L02_RS09275	COG1131	(ABC) transporter
I6L02_RS09285	COG1309	transcriptional regulator
I6L02_RS09290	COG0513	Belongs to the DEAD box helicase family
I6L02_RS09300	COG1199	ATP-dependent helicase activity
I6L02_RS09305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L02_RS09310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6L02_RS09320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L02_RS09345	COG0668	transmembrane transport
I6L02_RS09350	COG1126	abc transporter atp-binding protein
I6L02_RS09355	COG0765	amino acid transport
I6L02_RS09360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS09370	COG5006	permease, DMT superfamily
I6L02_RS09380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L02_RS09385	COG2194	sulfuric ester hydrolase activity
I6L02_RS09395	COG1321	iron dependent repressor
I6L02_RS09400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6L02_RS09405	COG1376	ErfK ybiS ycfS ynhG family protein
I6L02_RS09410	COG0488	(ABC) transporter
I6L02_RS09415	COG0561	phosphatase activity
I6L02_RS09420	COG1882	Formate acetyltransferase
I6L02_RS09425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L02_RS09430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L02_RS09435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L02_RS09440	COG0303	'Molybdopterin
I6L02_RS09445	COG1446	asparaginase
I6L02_RS09470	COG2200	EAL domain
I6L02_RS09475	COG2199	diguanylate cyclase activity
I6L02_RS09490	COG2133	pyrroloquinoline quinone binding
I6L02_RS09495	COG0625	glutathione transferase activity
I6L02_RS09500	COG1686	Belongs to the peptidase S11 family
I6L02_RS09505	COG1349	DNA-binding transcription factor activity
I6L02_RS09510	COG0671	phosphoesterase, PA-phosphatase related
I6L02_RS09515	COG2814	Major facilitator Superfamily
I6L02_RS09525	COG0561	phosphatase activity
I6L02_RS09530	COG0738	Major facilitator superfamily
I6L02_RS09535	COG3226	Transcriptional regulator
I6L02_RS09550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L02_RS09560	COG0778	Nitroreductase
I6L02_RS09575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L02_RS09580	COG3842	ATPase activity
I6L02_RS09585	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L02_RS09590	COG1177	transmembrane transport
I6L02_RS09605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS09610	COG4160	amino acid transport
I6L02_RS09615	COG4215	(ABC) transporter
I6L02_RS09620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS09625	COG1126	abc transporter atp-binding protein
I6L02_RS09640	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L02_RS09645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L02_RS09650	COG0702	epimerase
I6L02_RS09655	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6L02_RS09660	COG0028	Belongs to the TPP enzyme family
I6L02_RS09665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L02_RS09675	COG2431	L-lysine efflux transmembrane transporter activity
I6L02_RS09685	COG3593	DNA synthesis involved in DNA repair
I6L02_RS09690	COG2990	Protein conserved in bacteria
I6L02_RS09695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS09705	COG1278	Cold shock
I6L02_RS09755	COG0740	serine-type endopeptidase activity
I6L02_RS09775	COG0542	response to heat
I6L02_RS09780	COG1518	maintenance of DNA repeat elements
I6L02_RS09785	COG1203	CRISPR-associated helicase, Cas3
I6L02_RS09825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L02_RS09830	COG4988	ABC transporter
I6L02_RS09835	COG0492	ferredoxin-NADP+ reductase activity
I6L02_RS09840	COG1522	sequence-specific DNA binding
I6L02_RS09845	COG1178	ABC-type Fe3 transport system permease component
I6L02_RS09845	COG1674	ftsk spoiiie
I6L02_RS09855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L02_RS09865	COG0243	molybdopterin cofactor binding
I6L02_RS09870	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS09875	COG3302	dmso reductase anchor subunit
I6L02_RS09890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L02_RS09895	COG1882	Formate acetyltransferase
I6L02_RS09900	COG2116	formate transmembrane transporter activity
I6L02_RS09905	COG1944	ATP diphosphatase activity
I6L02_RS09910	COG2323	membrane
I6L02_RS09925	COG0501	Belongs to the peptidase M48B family
I6L02_RS09935	COG0539	negative regulation of cytoplasmic translation
I6L02_RS09945	COG2333	competence protein COMEC
I6L02_RS09945	COG0658	competence protein
I6L02_RS09960	COG3214	Protein conserved in bacteria
I6L02_RS09975	COG3173	Aminoglycoside phosphotransferase
I6L02_RS09980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L02_RS09985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L02_RS09995	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L02_RS10005	COG2989	Protein conserved in bacteria
I6L02_RS10010	COG3108	Peptidase M15
I6L02_RS10015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L02_RS10020	COG1448	Aminotransferase
I6L02_RS10040	COG0308	aminopeptidase N
I6L02_RS10045	COG1116	anion transmembrane transporter activity
I6L02_RS10050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L02_RS10060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L02_RS10065	COG0431	NADPH-dependent FMN reductase
I6L02_RS10080	COG3217	Mosc domain protein beta barrel domain protein
I6L02_RS10080	COG0633	Ferredoxin
I6L02_RS10090	COG0488	(ABC) transporter
I6L02_RS10095	COG2995	paraquat-inducible protein a
I6L02_RS10100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L02_RS10100	COG3008	intermembrane lipid transfer
I6L02_RS10105	COG3009	Protein conserved in bacteria
I6L02_RS10110	COG3130	regulation of translation
I6L02_RS10120	COG1067	ATP-dependent peptidase activity
I6L02_RS10130	COG2885	chlorophyll binding
I6L02_RS10130	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L02_RS10140	COG3070	regulator of competence-specific genes
I6L02_RS10145	COG1289	transmembrane transporter activity
I6L02_RS10150	COG3304	Inner membrane component domain
I6L02_RS10155	COG0210	DNA helicase
I6L02_RS10170	COG1832	CoA-binding protein
I6L02_RS10190	COG2920	part of a sulfur-relay system
I6L02_RS10195	COG0670	Belongs to the BI1 family
I6L02_RS10205	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L02_RS10210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L02_RS10215	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6L02_RS10220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L02_RS10225	COG1999	signal sequence binding
I6L02_RS10230	COG1773	rubredoxin
I6L02_RS10235	COG1271	oxidase subunit
I6L02_RS10240	COG1294	oxidase, subunit
I6L02_RS10255	COG1278	Cold shock
I6L02_RS10260	COG1278	Cold shock
I6L02_RS10280	COG0348	domain, Protein
I6L02_RS10285	COG2198	Histidine kinase
I6L02_RS10285	COG2205	protein histidine kinase activity
I6L02_RS10285	COG0784	Response regulator, receiver
I6L02_RS10290	COG0582	viral genome integration into host DNA
I6L02_RS10475	COG4626	Terminase
I6L02_RS10475	COG1802	Transcriptional regulator
I6L02_RS10485	COG4695	Portal protein
I6L02_RS10530	COG4386	tail sheath protein
I6L02_RS10550	COG4228	DNA circulation
I6L02_RS10570	COG3299	homolog of phage Mu protein gp47
I6L02_RS10575	COG3778	Protein conserved in bacteria
I6L02_RS10600	COG0463	Glycosyl transferase, family 2
I6L02_RS10605	COG2246	polysaccharide biosynthetic process
I6L02_RS10610	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS10615	COG0745	RESPONSE REGULATOR receiver
I6L02_RS10620	COG3005	denitrification pathway
I6L02_RS10625	COG0243	molybdopterin cofactor binding
I6L02_RS10660	COG3729	General stress protein
I6L02_RS10665	COG2233	PERMEase
I6L02_RS10700	COG1309	transcriptional regulator
I6L02_RS10705	COG0506	proline dehydrogenase activity
I6L02_RS10705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L02_RS10705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L02_RS10715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L02_RS10735	COG1702	phosphate starvation-inducible protein PhoH
I6L02_RS10740	COG3658	cytochrome
I6L02_RS10745	COG1215	transferase activity, transferring glycosyl groups
I6L02_RS10750	COG0726	polysaccharide deacetylase
I6L02_RS10750	COG1649	PFAM Uncharacterised BCR, COG1649
I6L02_RS10755	COG0457	Tetratricopeptide repeat
I6L02_RS10760	COG3706	GGDEF domain
I6L02_RS10780	COG3381	protein complex oligomerization
I6L02_RS10790	COG1462	curli production assembly transport component CsgG
I6L02_RS10805	COG2197	response regulator
I6L02_RS10830	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6L02_RS10835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L02_RS10850	COG2943	transferase activity, transferring hexosyl groups
I6L02_RS10855	COG5645	(Lipo)protein
I6L02_RS10870	COG1560	Kdo2-lipid A biosynthetic process
I6L02_RS10880	COG2353	YceI-like domain
I6L02_RS10885	COG3038	cytochrome b561
I6L02_RS10920	COG2999	glutathione oxidoreductase activity
I6L02_RS10930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L02_RS10940	COG0673	inositol 2-dehydrogenase activity
I6L02_RS10945	COG0728	peptidoglycan biosynthetic process
I6L02_RS10950	COG3418	PFAM FlgN family protein
I6L02_RS10955	COG2747	anti-sigma28 factor FlgM
I6L02_RS10960	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L02_RS10965	COG1815	bacterial-type flagellum-dependent cell motility
I6L02_RS10970	COG1558	bacterial-type flagellum-dependent cell motility
I6L02_RS10975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6L02_RS10980	COG1749	Flagellar hook protein flgE
I6L02_RS10985	COG4787	bacterial-type flagellum-dependent cell motility
I6L02_RS10990	COG4786	Flagellar basal body rod
I6L02_RS11005	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6L02_RS11005	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L02_RS11010	COG1256	bacterial-type flagellum assembly
I6L02_RS11015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L02_RS11020	COG1530	ribonuclease E activity
I6L02_RS11025	COG0564	pseudouridine synthase activity
I6L02_RS11030	COG0424	maF-like protein
I6L02_RS11035	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L02_RS11055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L02_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS11070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L02_RS11075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L02_RS11080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L02_RS11090	COG0470	DNA polymerase III
I6L02_RS11095	COG0084	hydrolase, TatD family'
I6L02_RS11100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS11100	COG1263	PTS System
I6L02_RS11105	COG4773	Receptor
I6L02_RS11110	COG0537	adenosine 5'-monophosphoramidase activity
I6L02_RS11115	COG5633	Lipoprotein
I6L02_RS11120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6L02_RS11140	COG1252	NADH dehydrogenase
I6L02_RS11145	COG3134	Outer membrane lipoprotein
I6L02_RS11150	COG1309	transcriptional regulator
I6L02_RS11160	COG1388	LysM domain
I6L02_RS11160	COG1376	ErfK ybiS ycfS ynhG family protein
I6L02_RS11165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L02_RS11170	COG4763	Acyl-transferase
I6L02_RS11175	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L02_RS11185	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L02_RS11195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6L02_RS11200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L02_RS11210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L02_RS11215	COG1177	transmembrane transport
I6L02_RS11225	COG3842	ATPase activity
I6L02_RS11235	COG2850	peptidyl-arginine hydroxylation
I6L02_RS11240	COG2205	protein histidine kinase activity
I6L02_RS11250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L02_RS11270	COG1187	pseudouridine synthase activity
I6L02_RS11275	COG0538	isocitrate dehydrogenase activity
I6L02_RS11280	COG0582	viral genome integration into host DNA
I6L02_RS11375	COG2076	Multidrug Resistance protein
I6L02_RS11385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L02_RS11450	COG3772	lysozyme
I6L02_RS11475	COG4220	transposase activity
I6L02_RS11495	COG1030	water channel activity
I6L02_RS11545	COG1196	nuclear chromosome segregation
I6L02_RS11580	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6L02_RS11595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L02_RS11600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L02_RS11605	COG1121	(ABC) transporter
I6L02_RS11620	COG0538	isocitrate dehydrogenase activity
I6L02_RS11630	COG5562	phage envelope protein
I6L02_RS11635	COG0789	Transcriptional regulator
I6L02_RS11640	COG2200	EAL domain
I6L02_RS11720	COG2894	cell division
I6L02_RS11745	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6L02_RS11760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L02_RS11765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L02_RS11785	COG2719	SpoVR family
I6L02_RS11795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L02_RS11805	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L02_RS11815	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6L02_RS11830	COG0157	Belongs to the NadC ModD family
I6L02_RS11835	COG0500	methyltransferase
I6L02_RS11840	COG1120	ATPase activity
I6L02_RS11845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS11850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L02_RS11860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS11860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L02_RS11860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6L02_RS11865	COG1461	Dihydroxyacetone kinase
I6L02_RS11870	COG2376	Dihydroxyacetone kinase
I6L02_RS11875	COG3284	Transcriptional regulator
I6L02_RS11885	COG0012	GTP binding
I6L02_RS11900	COG0659	secondary active sulfate transmembrane transporter activity
I6L02_RS11905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L02_RS11910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L02_RS11930	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L02_RS11935	COG3094	Invasion gene expression up-regulator, SirB
I6L02_RS11940	COG2912	Transglutaminase-like superfamily
I6L02_RS11955	COG0387	Pfam Sodium calcium exchanger
I6L02_RS11960	COG4572	Cation transport regulator
I6L02_RS11965	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6L02_RS11970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L02_RS11975	COG4932	domain protein
I6L02_RS11980	COG2197	response regulator
I6L02_RS11985	COG3850	Histidine kinase
I6L02_RS11990	COG2223	nitrite transmembrane transporter activity
I6L02_RS11995	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6L02_RS12000	COG1140	nitrate reductase beta subunit
I6L02_RS12005	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6L02_RS12010	COG2181	nitrate reductase activity
I6L02_RS12035	COG0788	formyltetrahydrofolate deformylase activity
I6L02_RS12045	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L02_RS12050	COG0745	RESPONSE REGULATOR receiver
I6L02_RS12055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L02_RS12065	COG1435	thymidine kinase activity
I6L02_RS12070	COG3385	transposase activity
I6L02_RS12075	COG1454	alcohol dehydrogenase
I6L02_RS12075	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS12080	COG2095	MarC family integral membrane protein
I6L02_RS12085	COG4166	transmembrane transport
I6L02_RS12090	COG0601	transmembrane transport
I6L02_RS12095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L02_RS12100	COG0444	Belongs to the ABC transporter superfamily
I6L02_RS12105	COG4608	Belongs to the ABC transporter superfamily
I6L02_RS12125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L02_RS12130	COG2350	Protein conserved in bacteria
I6L02_RS12190	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L02_RS12195	COG1607	acyl-coa hydrolase
I6L02_RS12215	COG3047	cAMP biosynthetic process
I6L02_RS12220	COG3685	Protein conserved in bacteria
I6L02_RS12225	COG3685	Protein conserved in bacteria
I6L02_RS12230	COG3729	General stress protein
I6L02_RS12235	COG0159	tryptophan synthase activity
I6L02_RS12245	COG0135	phosphoribosylanthranilate isomerase activity
I6L02_RS12245	COG0134	indole-3-glycerol-phosphate synthase activity
I6L02_RS12250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L02_RS12250	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L02_RS12255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L02_RS12265	COG0613	PHP domain protein
I6L02_RS12270	COG0009	L-threonylcarbamoyladenylate synthase
I6L02_RS12275	COG4907	membrane protein (DUF2207)
I6L02_RS12280	COG1187	pseudouridine synthase activity
I6L02_RS12285	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6L02_RS12290	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS12295	COG0616	signal peptide processing
I6L02_RS12305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L02_RS12310	COG0583	DNA-binding transcription factor activity
I6L02_RS12330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L02_RS12340	COG0671	phosphoesterase, PA-phosphatase related
I6L02_RS12345	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6L02_RS12350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L02_RS12360	COG0023	Translation Initiation Factor
I6L02_RS12370	COG1349	DNA-binding transcription factor activity
I6L02_RS12380	COG5001	Diguanylate cyclase
I6L02_RS12395	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L02_RS12395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L02_RS12400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L02_RS12410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS12415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L02_RS12425	COG2814	Major facilitator Superfamily
I6L02_RS12430	COG4172	Belongs to the ABC transporter superfamily
I6L02_RS12435	COG4172	Belongs to the ABC transporter superfamily
I6L02_RS12440	COG4171	peptide transport system, permease
I6L02_RS12445	COG4168	peptide transport system, permease
I6L02_RS12450	COG4166	transmembrane transport
I6L02_RS12465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L02_RS12470	COG1842	Phage shock protein A
I6L02_RS12480	COG1983	PspC domain protein
I6L02_RS12490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L02_RS12495	COG0366	Alpha amylase catalytic
I6L02_RS12500	COG1653	transport
I6L02_RS12505	COG1175	transmembrane transport
I6L02_RS12510	COG0395	ABC-type sugar transport system, permease component
I6L02_RS12515	COG1063	alcohol dehydrogenase
I6L02_RS12520	COG1082	Xylose isomerase domain protein TIM barrel
I6L02_RS12525	COG0673	inositol 2-dehydrogenase activity
I6L02_RS12530	COG1554	hydrolase, family 65, central catalytic
I6L02_RS12535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L02_RS12540	COG3842	ATPase activity
I6L02_RS12550	COG1609	Transcriptional regulator
I6L02_RS12555	COG3106	COG3106 Predicted ATPase
I6L02_RS12565	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6L02_RS12570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6L02_RS12575	COG4948	Mandelate Racemase Muconate Lactonizing
I6L02_RS12580	COG2866	Carboxypeptidase
I6L02_RS12585	COG0702	epimerase
I6L02_RS12590	COG1073	alpha beta
I6L02_RS12595	COG0583	DNA-binding transcription factor activity
I6L02_RS12600	COG4166	transmembrane transport
I6L02_RS12605	COG0668	transmembrane transport
I6L02_RS12610	COG3182	Iron-regulated membrane protein
I6L02_RS12615	COG0589	response to stress
I6L02_RS12620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L02_RS12625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L02_RS12635	COG2207	Transcriptional regulator
I6L02_RS12640	COG1566	PFAM secretion protein HlyD family protein
I6L02_RS12650	COG2840	Smr protein MutS2
I6L02_RS12655	COG3706	GGDEF domain
I6L02_RS12665	COG0513	Belongs to the DEAD box helicase family
I6L02_RS12690	COG0589	response to stress
I6L02_RS12695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L02_RS12700	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L02_RS12700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L02_RS12700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L02_RS12700	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L02_RS12705	COG3042	response to heat
I6L02_RS12710	COG3187	Heat shock protein
I6L02_RS12715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L02_RS12720	COG2911	Protein conserved in bacteria
I6L02_RS12730	COG3784	Protein of unknown function (DUF1318)
I6L02_RS12740	COG0667	Aldo Keto reductase
I6L02_RS12745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L02_RS12750	COG1643	Atp-dependent helicase
I6L02_RS12755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L02_RS12760	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS12765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L02_RS12770	COG3038	cytochrome b561
I6L02_RS12790	COG0583	DNA-binding transcription factor activity
I6L02_RS12795	COG5383	Protein conserved in bacteria
I6L02_RS12805	COG2841	Protein conserved in bacteria
I6L02_RS12810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L02_RS12815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L02_RS12820	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6L02_RS12825	COG0500	methyltransferase
I6L02_RS12835	COG3135	benzoate transporter
I6L02_RS12840	COG1396	sequence-specific DNA binding
I6L02_RS12845	COG0826	peptidase U32
I6L02_RS12860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L02_RS12865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L02_RS12870	COG3842	ATPase activity
I6L02_RS12875	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L02_RS12880	COG1177	transmembrane transport
I6L02_RS12905	COG3238	Protein conserved in bacteria
I6L02_RS12910	COG1247	-acetyltransferase
I6L02_RS12920	COG4772	TonB-dependent receptor
I6L02_RS12930	COG1113	amino acid transport
I6L02_RS12945	COG3501	Rhs element vgr protein
I6L02_RS12970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6L02_RS12975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6L02_RS12980	COG0384	phenazine biosynthesis protein PhzF
I6L02_RS12985	COG2181	nitrate reductase activity
I6L02_RS12990	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6L02_RS12995	COG1140	nitrate reductase beta subunit
I6L02_RS13000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6L02_RS13005	COG2223	nitrite transmembrane transporter activity
I6L02_RS13010	COG0697	spore germination
I6L02_RS13020	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS13025	COG2864	formate dehydrogenase
I6L02_RS13030	COG3093	addiction module antidote protein HigA
I6L02_RS13040	COG1064	alcohol dehydrogenase
I6L02_RS13060	COG1764	response to oxidative stress
I6L02_RS13065	COG2202	Pas domain
I6L02_RS13065	COG2200	EAL domain
I6L02_RS13065	COG2199	diguanylate cyclase activity
I6L02_RS13075	COG1649	PFAM Uncharacterised BCR, COG1649
I6L02_RS13080	COG0531	amino acid
I6L02_RS13085	COG0076	glutamate decarboxylase activity
I6L02_RS13100	COG0641	radical SAM
I6L02_RS13105	COG3119	arylsulfatase activity
I6L02_RS13110	COG2207	Transcriptional regulator
I6L02_RS13120	COG0243	molybdopterin cofactor binding
I6L02_RS13125	COG3539	Fimbrial protein
I6L02_RS13130	COG3539	Fimbrial protein
I6L02_RS13135	COG3539	Fimbrial protein
I6L02_RS13140	COG3188	usher protein
I6L02_RS13150	COG3539	Fimbrial protein
I6L02_RS13160	COG0702	epimerase
I6L02_RS13200	COG3550	peptidyl-serine autophosphorylation
I6L02_RS13205	COG1396	sequence-specific DNA binding
I6L02_RS13210	COG4106	trans-aconitate 2-methyltransferase activity
I6L02_RS13215	COG3781	membrane
I6L02_RS13225	COG2199	diguanylate cyclase activity
I6L02_RS13235	COG2066	Belongs to the glutaminase family
I6L02_RS13240	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS13245	COG0583	DNA-binding transcription factor activity
I6L02_RS13265	COG1846	Transcriptional regulator
I6L02_RS13270	COG4977	sequence-specific DNA binding
I6L02_RS13280	COG2723	6-phospho-beta-galactosidase activity
I6L02_RS13290	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L02_RS13295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L02_RS13305	COG2188	Transcriptional regulator
I6L02_RS13310	COG0697	spore germination
I6L02_RS13315	COG2814	Major facilitator Superfamily
I6L02_RS13325	COG3706	GGDEF domain
I6L02_RS13330	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L02_RS13335	COG0339	signal peptide processing
I6L02_RS13340	COG4221	oxidoreductase activity
I6L02_RS13345	COG1802	Transcriptional regulator
I6L02_RS13355	COG0246	Mannitol dehydrogenase
I6L02_RS13360	COG0477	Major facilitator Superfamily
I6L02_RS13365	COG1063	alcohol dehydrogenase
I6L02_RS13370	COG4948	Mandelate Racemase Muconate Lactonizing
I6L02_RS13385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L02_RS13405	COG3381	protein complex oligomerization
I6L02_RS13415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L02_RS13420	COG1940	carbohydrate kinase activity
I6L02_RS13425	COG0583	DNA-binding transcription factor activity
I6L02_RS13430	COG2814	Major facilitator Superfamily
I6L02_RS13445	COG3591	Belongs to the peptidase S1B family
I6L02_RS13460	COG0628	permease
I6L02_RS13465	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L02_RS13470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L02_RS13480	COG0531	amino acid
I6L02_RS13490	COG3136	membrane protein required for alginate biosynthesis
I6L02_RS13495	COG0745	RESPONSE REGULATOR receiver
I6L02_RS13500	COG2205	protein histidine kinase activity
I6L02_RS13510	COG0114	fumarate hydratase activity
I6L02_RS13515	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L02_RS13515	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L02_RS13520	COG1482	cell wall glycoprotein biosynthetic process
I6L02_RS13525	COG5339	Protein conserved in bacteria
I6L02_RS13540	COG3250	beta-galactosidase activity
I6L02_RS13545	COG1309	transcriptional regulator
I6L02_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS13555	COG1609	Transcriptional regulator
I6L02_RS13560	COG1263	PTS System
I6L02_RS13560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS13565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L02_RS13575	COG0673	inositol 2-dehydrogenase activity
I6L02_RS13615	COG4659	FMN binding
I6L02_RS13625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L02_RS13630	COG3104	oligopeptide transport
I6L02_RS13635	COG0625	glutathione transferase activity
I6L02_RS13655	COG3895	Periplasmic Protein
I6L02_RS13665	COG3133	Outer membrane lipoprotein
I6L02_RS13680	COG1566	PFAM secretion protein HlyD family protein
I6L02_RS13685	COG1289	transmembrane transporter activity
I6L02_RS13690	COG2032	superoxide dismutase activity
I6L02_RS13695	COG4989	oxidoreductase activity
I6L02_RS13700	COG3313	Fe-S protein
I6L02_RS13705	COG1309	transcriptional regulator
I6L02_RS13710	COG1902	pentaerythritol trinitrate reductase activity
I6L02_RS13715	COG0346	lactoylglutathione lyase activity
I6L02_RS13725	COG1201	RNA secondary structure unwinding
I6L02_RS13730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L02_RS13735	COG0791	NLP P60 protein
I6L02_RS13740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L02_RS13745	COG2814	Major facilitator Superfamily
I6L02_RS13760	COG0583	DNA-binding transcription factor activity
I6L02_RS13765	COG2814	Major facilitator Superfamily
I6L02_RS13770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L02_RS13775	COG0307	riboflavin synthase, alpha
I6L02_RS13785	COG3468	outer membrane autotransporter barrel domain protein
I6L02_RS13805	COG4529	Protein conserved in bacteria
I6L02_RS13815	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6L02_RS13820	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS13830	COG2414	aldehyde ferredoxin oxidoreductase
I6L02_RS13835	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS13845	COG0469	pyruvate kinase activity
I6L02_RS13850	COG4238	major outer membrane lipoprotein
I6L02_RS13855	COG1376	ErfK ybiS ycfS ynhG family protein
I6L02_RS13870	COG0719	Fe-S assembly protein
I6L02_RS13875	COG0396	ATPase activity
I6L02_RS13880	COG0719	Fe-S assembly protein
I6L02_RS13885	COG0316	Belongs to the HesB IscA family
I6L02_RS13895	COG2050	protein possibly involved in aromatic compounds catabolism
I6L02_RS13900	COG0277	FAD linked oxidase domain protein
I6L02_RS13900	COG0247	lactate metabolic process
I6L02_RS13905	COG0628	permease
I6L02_RS13920	COG0738	Major facilitator superfamily
I6L02_RS13925	COG2271	Major facilitator Superfamily
I6L02_RS13940	COG4670	ketone body catabolic process
I6L02_RS13945	COG1960	acyl-CoA dehydrogenase activity
I6L02_RS13950	COG2207	Transcriptional regulator
I6L02_RS13950	COG1917	Cupin 2, conserved barrel domain protein
I6L02_RS13955	COG2086	electron transfer activity
I6L02_RS13960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6L02_RS13965	COG0644	oxidoreductase
I6L02_RS13970	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L02_RS13975	COG0318	PFAM AMP-dependent synthetase and ligase
I6L02_RS13980	COG0574	Belongs to the PEP-utilizing enzyme family
I6L02_RS13980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L02_RS13990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L02_RS13995	COG4256	Hemin uptake protein
I6L02_RS14005	COG2200	EAL domain
I6L02_RS14010	COG0791	NLP P60 protein
I6L02_RS14020	COG0386	Belongs to the glutathione peroxidase family
I6L02_RS14080	COG3137	Salt-induced outer membrane protein
I6L02_RS14085	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L02_RS14095	COG3001	Fructosamine kinase
I6L02_RS14105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L02_RS14110	COG1988	membrane-bound metal-dependent
I6L02_RS14115	COG1823	symporter activity
I6L02_RS14125	COG0753	catalase activity
I6L02_RS14130	COG3394	polysaccharide catabolic process
I6L02_RS14135	COG1486	melibiose metabolic process
I6L02_RS14140	COG2169	Transcriptional regulator
I6L02_RS14140	COG1917	Cupin 2, conserved barrel domain protein
I6L02_RS14145	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L02_RS14150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L02_RS14155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L02_RS14160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L02_RS14170	COG0322	excinuclease ABC activity
I6L02_RS14180	COG3678	ATP-independent chaperone mediated protein folding
I6L02_RS14195	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS14210	COG0708	Exodeoxyribonuclease III
I6L02_RS14215	COG0398	Pfam SNARE associated Golgi protein
I6L02_RS14225	COG0398	Pfam SNARE associated Golgi protein
I6L02_RS14230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L02_RS14235	COG4134	Bacterial extracellular solute-binding protein
I6L02_RS14240	COG4135	transport system, permease component
I6L02_RS14245	COG4136	ATPase activity
I6L02_RS14250	COG2897	thiosulfate sulfurtransferase activity
I6L02_RS14255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L02_RS14260	COG0494	nUDIX hydrolase
I6L02_RS14270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L02_RS14275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L02_RS14285	COG0778	Nitroreductase
I6L02_RS14290	COG0616	signal peptide processing
I6L02_RS14295	COG0252	asparaginase activity
I6L02_RS14300	COG1335	isochorismatase
I6L02_RS14305	COG2814	Major facilitator Superfamily
I6L02_RS14310	COG1349	DNA-binding transcription factor activity
I6L02_RS14315	COG0667	Aldo Keto reductase
I6L02_RS14320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS14325	COG0191	fructose-bisphosphate aldolase activity
I6L02_RS14330	COG1063	alcohol dehydrogenase
I6L02_RS14335	COG2271	Major facilitator Superfamily
I6L02_RS14340	COG1063	alcohol dehydrogenase
I6L02_RS14345	COG3139	Protein of unknown function (DUF1315)
I6L02_RS14355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L02_RS14360	COG0676	glucose-6-phosphate 1-epimerase activity
I6L02_RS14365	COG0656	L-ascorbic acid biosynthetic process
I6L02_RS14370	COG3713	MltA-interacting MipA family protein
I6L02_RS14375	COG2766	serine protein kinase
I6L02_RS14385	COG2199	diguanylate cyclase activity
I6L02_RS14390	COG2199	diguanylate cyclase activity
I6L02_RS14395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L02_RS14410	COG2207	Transcriptional regulator
I6L02_RS14415	COG2807	transmembrane transport
I6L02_RS14420	COG3189	MarR family transcriptional regulator
I6L02_RS14425	COG3042	response to heat
I6L02_RS14430	COG2199	diguanylate cyclase activity
I6L02_RS14430	COG2203	Gaf domain
I6L02_RS14445	COG2261	transglycosylase associated protein
I6L02_RS14455	COG3615	Tellurite resistance protein tehB
I6L02_RS14465	COG0583	DNA-binding transcription factor activity
I6L02_RS14470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6L02_RS14475	COG0318	PFAM AMP-dependent synthetase and ligase
I6L02_RS14480	COG3065	identical protein binding
I6L02_RS14485	COG1214	PFAM Peptidase M22, glycoprotease
I6L02_RS14490	COG1199	ATP-dependent helicase activity
I6L02_RS14495	COG0251	oxidation-reduction process
I6L02_RS14510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L02_RS14520	COG1760	l-serine dehydratase
I6L02_RS14525	COG2200	EAL domain
I6L02_RS14530	COG1253	flavin adenine dinucleotide binding
I6L02_RS14535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS14535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS14540	COG3715	PTS system
I6L02_RS14545	COG3716	PTS system mannose fructose sorbose family IID component
I6L02_RS14560	COG2226	methyltransferase
I6L02_RS14590	COG1414	Transcriptional regulator
I6L02_RS14595	COG2814	Major facilitator Superfamily
I6L02_RS14605	COG0793	Belongs to the peptidase S41A family
I6L02_RS14615	COG1956	GAF domain-containing protein
I6L02_RS14620	COG2995	paraquat-inducible protein a
I6L02_RS14625	COG3008	intermembrane lipid transfer
I6L02_RS14645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L02_RS14655	COG1276	copper resistance
I6L02_RS14660	COG2372	response to copper ion
I6L02_RS14670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L02_RS14675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L02_RS14680	COG1770	oligopeptidase
I6L02_RS14685	COG2979	Protein of unknown function (DUF533)
I6L02_RS14695	COG3141	response to X-ray
I6L02_RS14705	COG0800	Aldolase
I6L02_RS14710	COG0129	dihydroxy-acid dehydratase activity
I6L02_RS14715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6L02_RS14720	COG1737	Transcriptional regulator
I6L02_RS14725	COG0469	pyruvate kinase activity
I6L02_RS14730	COG1560	Kdo2-lipid A biosynthetic process
I6L02_RS14735	COG0739	heme binding
I6L02_RS14740	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L02_RS14750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L02_RS14780	COG0217	transcriptional regulatory protein
I6L02_RS14785	COG0494	nUDIX hydrolase
I6L02_RS14795	COG1335	isochorismatase
I6L02_RS14800	COG1801	Protein of unknown function DUF72
I6L02_RS14805	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L02_RS14820	COG0243	molybdopterin cofactor binding
I6L02_RS14825	COG3005	denitrification pathway
I6L02_RS14835	COG3102	Protein conserved in bacteria
I6L02_RS14850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L02_RS14855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L02_RS14860	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L02_RS14865	COG0745	RESPONSE REGULATOR receiver
I6L02_RS14875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L02_RS14885	COG0840	transmembrane signaling receptor activity
I6L02_RS14890	COG0835	chemotaxis
I6L02_RS14895	COG0643	Histidine kinase
I6L02_RS14895	COG2198	Histidine kinase
I6L02_RS14900	COG1360	Flagellar Motor Protein
I6L02_RS14905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L02_RS14920	COG0589	response to stress
I6L02_RS14930	COG1877	trehalose-phosphatase activity
I6L02_RS14935	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS14940	COG1129	ABC transporter
I6L02_RS14945	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS14950	COG1528	Iron-storage protein
I6L02_RS14970	COG1528	Iron-storage protein
I6L02_RS14980	COG0814	amino acid
I6L02_RS14985	COG3318	Belongs to the UPF0149 family
I6L02_RS14985	COG3012	SEC-C Motif Domain Protein
I6L02_RS15015	COG2197	response regulator
I6L02_RS15030	COG2197	response regulator
I6L02_RS15035	COG1126	abc transporter atp-binding protein
I6L02_RS15040	COG0765	amino acid transport
I6L02_RS15045	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6L02_RS15050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS15060	COG1191	sigma factor activity
I6L02_RS15070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6L02_RS15075	COG1516	flagellar protein fliS
I6L02_RS15085	COG0366	Alpha amylase catalytic
I6L02_RS15095	COG2391	methyltransferase activity
I6L02_RS15100	COG0425	Belongs to the sulfur carrier protein TusA family
I6L02_RS15105	COG2135	peptidase activity
I6L02_RS15120	COG2207	Transcriptional regulator
I6L02_RS15125	COG1881	PFAM PEBP family protein
I6L02_RS15130	COG2076	Multidrug Resistance protein
I6L02_RS15140	COG1766	The M ring may be actively involved in energy transduction
I6L02_RS15145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L02_RS15150	COG1317	bacterial-type flagellum organization
I6L02_RS15155	COG1157	protein secretion by the type III secretion system
I6L02_RS15160	COG2882	bacterial-type flagellum organization
I6L02_RS15165	COG3144	bacterial-type flagellum assembly
I6L02_RS15170	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L02_RS15175	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L02_RS15180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L02_RS15185	COG3190	flagellar
I6L02_RS15190	COG1338	Plays a role in the flagellum-specific transport system
I6L02_RS15195	COG1987	bacterial-type flagellum assembly
I6L02_RS15200	COG1684	flagellar biosynthetic protein fliR
I6L02_RS15205	COG2197	response regulator
I6L02_RS15230	COG5475	Uncharacterized small protein (DUF2158)
I6L02_RS15235	COG2354	Protein conserved in bacteria
I6L02_RS15240	COG0697	spore germination
I6L02_RS15245	COG3727	T/G mismatch-specific endonuclease activity
I6L02_RS15250	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6L02_RS15255	COG1418	mRNA catabolic process
I6L02_RS15265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L02_RS15275	COG2205	protein histidine kinase activity
I6L02_RS15280	COG0745	RESPONSE REGULATOR receiver
I6L02_RS15285	COG2351	hydroxyisourate hydrolase activity
I6L02_RS15290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6L02_RS15295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6L02_RS15300	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6L02_RS15305	COG0582	viral genome integration into host DNA
I6L02_RS15445	COG0582	viral genome integration into host DNA
I6L02_RS15450	COG1169	isochorismate synthase
I6L02_RS15455	COG2814	Major facilitator Superfamily
I6L02_RS15460	COG1132	(ABC) transporter
I6L02_RS15475	COG2226	methyltransferase
I6L02_RS15475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L02_RS15475	COG3433	isochorismatase activity
I6L02_RS15495	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L02_RS15500	COG4771	TonB-dependent receptor
I6L02_RS15505	COG2373	Large extracellular alpha-helical protein
I6L02_RS15505	COG4932	domain protein
I6L02_RS15505	COG1388	LysM domain
I6L02_RS15520	COG0477	Major facilitator Superfamily
I6L02_RS15525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L02_RS15530	COG0217	transcriptional regulatory protein
I6L02_RS15540	COG0534	Mate efflux family protein
I6L02_RS15550	COG0583	DNA-binding transcription factor activity
I6L02_RS15555	COG0583	DNA-binding transcription factor activity
I6L02_RS15565	COG0582	viral genome integration into host DNA
I6L02_RS15605	COG3423	Transcriptional regulator
I6L02_RS15615	COG5433	transposase activity
I6L02_RS15635	COG1074	ATP-dependent DNA helicase activity
I6L02_RS15640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L02_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS15650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L02_RS15655	COG3775	system Galactitol-specific IIC component
I6L02_RS15660	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L02_RS15670	COG1349	DNA-binding transcription factor activity
I6L02_RS15675	COG0698	ribose 5-phosphate isomerase
I6L02_RS15680	COG3775	system Galactitol-specific IIC component
I6L02_RS15685	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L02_RS15690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS15700	COG1376	ErfK ybiS ycfS ynhG family protein
I6L02_RS15715	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6L02_RS15775	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6L02_RS15790	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6L02_RS15800	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS15805	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS15805	COG1454	alcohol dehydrogenase
I6L02_RS15810	COG4656	Part of a membrane complex involved in electron transport
I6L02_RS15835	COG1289	transmembrane transporter activity
I6L02_RS15845	COG1686	Belongs to the peptidase S11 family
I6L02_RS15850	COG2925	Exonuclease
I6L02_RS15855	COG0531	amino acid
I6L02_RS15865	COG0583	DNA-binding transcription factor activity
I6L02_RS15870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L02_RS15875	COG4115	mRNA cleavage
I6L02_RS15880	COG2161	toxin-antitoxin pair type II binding
I6L02_RS15895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L02_RS15905	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L02_RS15905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L02_RS15910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L02_RS15930	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L02_RS15940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6L02_RS15945	COG0463	Glycosyl transferase, family 2
I6L02_RS15960	COG0463	Glycosyl transferase, family 2
I6L02_RS15975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L02_RS15980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L02_RS15990	COG0438	transferase activity, transferring glycosyl groups
I6L02_RS15995	COG2327	Polysaccharide pyruvyl transferase
I6L02_RS16000	COG2244	polysaccharide biosynthetic process
I6L02_RS16005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L02_RS16010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L02_RS16015	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6L02_RS16015	COG0662	Cupin 2, conserved barrel domain protein
I6L02_RS16020	COG0297	glycogen (starch) synthase activity
I6L02_RS16025	COG1051	belongs to the nudix hydrolase family
I6L02_RS16030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L02_RS16035	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6L02_RS16040	COG0110	maltose O-acetyltransferase activity
I6L02_RS16045	COG1216	Glycosyl transferase, family 2
I6L02_RS16055	COG0438	transferase activity, transferring glycosyl groups
I6L02_RS16060	COG1045	serine acetyltransferase
I6L02_RS16065	COG0463	Glycosyl transferase, family 2
I6L02_RS16070	COG0489	protein tyrosine kinase activity
I6L02_RS16070	COG3206	protein involved in exopolysaccharide biosynthesis
I6L02_RS16075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L02_RS16080	COG1596	polysaccharide export
I6L02_RS16085	COG1253	flavin adenine dinucleotide binding
I6L02_RS16090	COG2982	Protein involved in outer membrane biogenesis
I6L02_RS16100	COG0572	uridine kinase
I6L02_RS16105	COG5002	protein histidine kinase activity
I6L02_RS16105	COG5001	Diguanylate cyclase
I6L02_RS16105	COG3447	MASE1 domain protein
I6L02_RS16110	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6L02_RS16115	COG0443	Heat shock 70 kDa protein
I6L02_RS16120	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6L02_RS16125	COG0631	protein serine/threonine phosphatase activity
I6L02_RS16130	COG4245	von Willebrand factor, type A
I6L02_RS16165	COG2205	protein histidine kinase activity
I6L02_RS16170	COG0745	RESPONSE REGULATOR receiver
I6L02_RS16175	COG3422	double-strand break repair
I6L02_RS16200	COG0826	peptidase U32
I6L02_RS16220	COG1063	alcohol dehydrogenase
I6L02_RS16225	COG3775	system Galactitol-specific IIC component
I6L02_RS16230	COG3414	Phosphotransferase system galactitol-specific IIB component
I6L02_RS16235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS16245	COG0191	fructose-bisphosphate aldolase activity
I6L02_RS16250	COG1830	Aldolase
I6L02_RS16255	COG2211	Major facilitator Superfamily
I6L02_RS16260	COG1397	ADP-ribosylglycohydrolase
I6L02_RS16265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS16270	COG2188	Transcriptional regulator
I6L02_RS16275	COG3757	hydrolase, family 25
I6L02_RS16280	COG0351	phosphomethylpyrimidine kinase
I6L02_RS16300	COG5455	response to cobalt ion
I6L02_RS16305	COG3539	Fimbrial protein
I6L02_RS16310	COG3188	usher protein
I6L02_RS16315	COG3121	Chaperone
I6L02_RS16320	COG3539	Fimbrial protein
I6L02_RS16330	COG0489	protein tyrosine kinase activity
I6L02_RS16340	COG3831	ATPase activity
I6L02_RS16345	COG3831	ATPase activity
I6L02_RS16355	COG0714	Associated with various cellular activities
I6L02_RS16360	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L02_RS16365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6L02_RS16370	COG4715	Zinc finger, swim domain protein
I6L02_RS16375	COG4808	Protein conserved in bacteria
I6L02_RS16380	COG4807	Protein conserved in bacteria
I6L02_RS16385	COG3279	Response regulator of the LytR AlgR family
I6L02_RS16390	COG3275	phosphorelay sensor kinase activity
I6L02_RS16395	COG0789	Transcriptional regulator
I6L02_RS16405	COG1174	glycine betaine transport
I6L02_RS16410	COG1125	glycine betaine transport
I6L02_RS16415	COG1174	glycine betaine transport
I6L02_RS16420	COG1732	Glycine betaine
I6L02_RS16425	COG1472	Belongs to the glycosyl hydrolase 3 family
I6L02_RS16430	COG0277	FAD linked oxidase domain protein
I6L02_RS16435	COG1686	Belongs to the peptidase S11 family
I6L02_RS16445	COG0586	Pfam SNARE associated Golgi protein
I6L02_RS16450	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS16455	COG1538	Outer membrane efflux protein
I6L02_RS16465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L02_RS16475	COG1346	cytolysis
I6L02_RS16485	COG2949	membrane
I6L02_RS16495	COG0493	'glutamate synthase
I6L02_RS16500	COG0167	dihydroorotate dehydrogenase activity
I6L02_RS16500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L02_RS16505	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS16515	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS16520	COG1609	Transcriptional regulator
I6L02_RS16525	COG2311	Membrane
I6L02_RS16540	COG4771	TonB-dependent receptor
I6L02_RS16545	COG0833	amino acid
I6L02_RS16550	COG0583	DNA-binding transcription factor activity
I6L02_RS16555	COG2855	membrane
I6L02_RS16565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS16565	COG1522	sequence-specific DNA binding
I6L02_RS16575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L02_RS16580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L02_RS16585	COG2313	pseudouridylate synthase activity
I6L02_RS16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS16595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS16595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS16595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L02_RS16600	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L02_RS16605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS16605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS16610	COG2814	Major facilitator Superfamily
I6L02_RS16625	COG0246	Mannitol dehydrogenase
I6L02_RS16630	COG0523	cobalamin synthesis protein
I6L02_RS16635	COG0671	phosphoesterase, PA-phosphatase related
I6L02_RS16640	COG0791	NLP P60 protein
I6L02_RS16645	COG2200	EAL domain
I6L02_RS16650	COG4166	transmembrane transport
I6L02_RS16655	COG4174	ABC transporter (Permease)
I6L02_RS16660	COG4239	(ABC) transporter, permease
I6L02_RS16665	COG4172	Belongs to the ABC transporter superfamily
I6L02_RS16675	COG2814	Major facilitator Superfamily
I6L02_RS16680	COG1187	pseudouridine synthase activity
I6L02_RS16685	COG1061	Type III restriction enzyme res subunit
I6L02_RS16705	COG3083	sulfuric ester hydrolase activity
I6L02_RS16720	COG2197	response regulator
I6L02_RS16725	COG4235	cytochrome complex assembly
I6L02_RS16725	COG3088	subunit of a heme lyase
I6L02_RS16730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L02_RS16735	COG1138	Cytochrome C-type biogenesis protein
I6L02_RS16745	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L02_RS16750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L02_RS16755	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L02_RS16765	COG3005	denitrification pathway
I6L02_RS16770	COG3043	anaerobic respiration
I6L02_RS16775	COG0348	domain, Protein
I6L02_RS16780	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS16790	COG3062	negative regulation of establishment of protein localization
I6L02_RS16795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS16795	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS16810	COG0579	oxidoreductase
I6L02_RS16815	COG4615	Cyclic peptide transporter
I6L02_RS16820	COG3145	DNA-N1-methyladenine dioxygenase activity
I6L02_RS16825	COG2169	Transcriptional regulator
I6L02_RS16825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L02_RS16830	COG1477	protein flavinylation
I6L02_RS16835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L02_RS16840	COG0642	Histidine kinase
I6L02_RS16840	COG2198	Histidine kinase
I6L02_RS16845	COG2197	response regulator
I6L02_RS16850	COG2205	protein histidine kinase activity
I6L02_RS16850	COG0784	Response regulator, receiver
I6L02_RS16855	COG3852	Histidine kinase
I6L02_RS16860	COG2204	response regulator
I6L02_RS16865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6L02_RS16870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6L02_RS16875	COG2031	fatty acid transporter
I6L02_RS16880	COG0183	Belongs to the thiolase family
I6L02_RS16885	COG4676	Protein conserved in bacteria
I6L02_RS16890	COG5445	Predicted secreted protein (DUF2300)
I6L02_RS16900	COG3234	Protein of unknown function (DUF1175)
I6L02_RS16905	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6L02_RS16910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6L02_RS16920	COG3468	outer membrane autotransporter barrel domain protein
I6L02_RS16925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L02_RS16930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L02_RS16935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L02_RS16940	COG3642	lipopolysaccharide core region biosynthetic process
I6L02_RS16945	COG0584	glycerophosphoryl diester phosphodiesterase
I6L02_RS16950	COG2271	Major facilitator Superfamily
I6L02_RS16955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L02_RS16965	COG0247	lactate metabolic process
I6L02_RS16970	COG5464	transposase or invertase
I6L02_RS16985	COG2271	Major facilitator Superfamily
I6L02_RS16990	COG4948	Mandelate Racemase Muconate Lactonizing
I6L02_RS16995	COG1414	Transcriptional regulator
I6L02_RS17060	COG0318	PFAM AMP-dependent synthetase and ligase
I6L02_RS17070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L02_RS17085	COG1169	isochorismate synthase
I6L02_RS17090	COG4575	ribosome binding
I6L02_RS17095	COG2153	protein acetylation
I6L02_RS17105	COG2304	oxidoreductase activity
I6L02_RS17110	COG2234	aminopeptidase activity
I6L02_RS17125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L02_RS17130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6L02_RS17140	COG0839	Belongs to the complex I subunit 6 family
I6L02_RS17155	COG1034	ATP synthesis coupled electron transport
I6L02_RS17160	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6L02_RS17165	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6L02_RS17185	COG0583	DNA-binding transcription factor activity
I6L02_RS17190	COG0436	Aminotransferase
I6L02_RS17200	COG0490	domain, Protein
I6L02_RS17200	COG0471	metal ion transport
I6L02_RS17205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L02_RS17220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L02_RS17225	COG0280	phosphate acetyltransferase
I6L02_RS17225	COG0857	belongs to the CobB CobQ family
I6L02_RS17230	COG1288	antiporter activity
I6L02_RS17235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L02_RS17240	COG0622	Phosphoesterase
I6L02_RS17245	COG0625	glutathione transferase activity
I6L02_RS17250	COG0625	glutathione transferase activity
I6L02_RS17255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L02_RS17260	COG1090	epimerase
I6L02_RS17265	COG5464	transposase or invertase
I6L02_RS17270	COG4598	ABC transporter
I6L02_RS17275	COG4160	amino acid transport
I6L02_RS17280	COG4215	(ABC) transporter
I6L02_RS17285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS17290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS17295	COG0163	prenyltransferase activity
I6L02_RS17300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L02_RS17305	COG1286	toxin biosynthetic process
I6L02_RS17310	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L02_RS17315	COG0285	dihydrofolate synthase activity
I6L02_RS17325	COG0586	Pfam SNARE associated Golgi protein
I6L02_RS17335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L02_RS17350	COG2814	Major facilitator Superfamily
I6L02_RS17355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L02_RS17370	COG3101	peptidyl-lysine hydroxylation
I6L02_RS17375	COG0730	response to heat
I6L02_RS17405	COG3539	Fimbrial protein
I6L02_RS17410	COG3539	Fimbrial protein
I6L02_RS17415	COG3539	Fimbrial protein
I6L02_RS17420	COG3121	Chaperone
I6L02_RS17425	COG3188	usher protein
I6L02_RS17430	COG3539	Fimbrial protein
I6L02_RS17435	COG2062	phosphohistidine phosphatase, SixA
I6L02_RS17450	COG3691	Protein conserved in bacteria
I6L02_RS17455	COG2067	long-chain fatty acid transport protein
I6L02_RS17465	COG2116	formate transmembrane transporter activity
I6L02_RS17475	COG0583	DNA-binding transcription factor activity
I6L02_RS17480	COG2610	gluconate transmembrane transporter activity
I6L02_RS17485	COG3048	D-serine ammonia-lyase activity
I6L02_RS17490	COG0477	Major facilitator Superfamily
I6L02_RS17495	COG1566	PFAM secretion protein HlyD family protein
I6L02_RS17500	COG2197	response regulator
I6L02_RS17505	COG0784	Response regulator, receiver
I6L02_RS17505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS17505	COG2198	Histidine kinase
I6L02_RS17505	COG2205	protein histidine kinase activity
I6L02_RS17510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6L02_RS17515	COG0679	Auxin Efflux Carrier
I6L02_RS17520	COG0028	Belongs to the TPP enzyme family
I6L02_RS17545	COG1560	Kdo2-lipid A biosynthetic process
I6L02_RS17555	COG0436	Aminotransferase
I6L02_RS17560	COG3275	phosphorelay sensor kinase activity
I6L02_RS17565	COG3279	Response regulator of the LytR AlgR family
I6L02_RS17570	COG2207	Transcriptional regulator
I6L02_RS17575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L02_RS17575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS17575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS17580	COG1363	Peptidase, m42
I6L02_RS17585	COG0006	proline dipeptidase activity
I6L02_RS17590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS17595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L02_RS17605	COG0038	chloride channel
I6L02_RS17620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L02_RS17625	COG2199	diguanylate cyclase activity
I6L02_RS17625	COG2200	EAL domain
I6L02_RS17640	COG3415	Transposase
I6L02_RS17645	COG3415	Transposase
I6L02_RS17650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L02_RS17675	COG0583	DNA-binding transcription factor activity
I6L02_RS17685	COG2211	Major facilitator Superfamily
I6L02_RS17690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6L02_RS17700	COG0583	DNA-binding transcription factor activity
I6L02_RS17705	COG0385	Bile acid
I6L02_RS17710	COG3530	Putative quorum-sensing-regulated virulence factor
I6L02_RS17730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L02_RS17735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS17740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L02_RS17745	COG2190	(PTS) system
I6L02_RS17760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L02_RS17765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L02_RS17770	COG4208	sulfate ABC transporter
I6L02_RS17775	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L02_RS17780	COG4150	thiosulfate binding
I6L02_RS17785	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS17800	COG2837	iron assimilation
I6L02_RS17820	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L02_RS17830	COG2207	Transcriptional regulator
I6L02_RS17835	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6L02_RS17840	COG4816	utilization protein
I6L02_RS17850	COG4303	Ethanolamine ammonia lyase large subunit
I6L02_RS17855	COG4819	ethanolamine utilization protein
I6L02_RS17860	COG3192	ethanolamine utilization protein
I6L02_RS17865	COG1454	alcohol dehydrogenase
I6L02_RS17870	COG4820	ethanolamine utilization protein (EutJ)
I6L02_RS17875	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS17880	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6L02_RS17885	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6L02_RS17890	COG0280	phosphate acetyltransferase
I6L02_RS17895	COG4812	Cobalamin adenosyltransferase
I6L02_RS17900	COG4766	ethanolamine catabolic process
I6L02_RS17905	COG4917	ethanolamine utilization protein
I6L02_RS17910	COG4810	utilization protein
I6L02_RS17915	COG0281	malic enzyme
I6L02_RS17915	COG0280	phosphate acetyltransferase
I6L02_RS17920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L02_RS17925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L02_RS17930	COG5342	invasion associated locus B
I6L02_RS17940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS17940	COG0493	'glutamate synthase
I6L02_RS17945	COG3850	Histidine kinase
I6L02_RS17950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L02_RS17960	COG1393	Belongs to the ArsC family
I6L02_RS17975	COG0400	carboxylic ester hydrolase activity
I6L02_RS17985	COG2321	neutral zinc metallopeptidase
I6L02_RS17995	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L02_RS18005	COG2716	regulation of RNA biosynthetic process
I6L02_RS18010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L02_RS18015	COG0628	permease
I6L02_RS18020	COG4783	chaperone-mediated protein folding
I6L02_RS18025	COG1393	Belongs to the ArsC family
I6L02_RS18035	COG2233	PERMEase
I6L02_RS18050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L02_RS18055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L02_RS18060	COG0248	Ppx GppA phosphatase
I6L02_RS18065	COG2200	EAL domain
I6L02_RS18080	COG3133	Outer membrane lipoprotein
I6L02_RS18095	COG0517	IMP dehydrogenase activity
I6L02_RS18095	COG0516	GMP reductase activity
I6L02_RS18120	COG1645	bacterial-type flagellum-dependent swarming motility
I6L02_RS18135	COG2976	Protein conserved in bacteria
I6L02_RS18165	COG4953	penicillin-binding protein 1C
I6L02_RS18170	COG2373	Large extracellular alpha-helical protein
I6L02_RS18175	COG2897	thiosulfate sulfurtransferase activity
I6L02_RS18190	COG2975	iron-sulfur cluster assembly
I6L02_RS18195	COG0633	Ferredoxin
I6L02_RS18215	COG0822	iron-sulfur transferase activity
I6L02_RS18235	COG0483	inositol monophosphate 1-phosphatase activity
I6L02_RS18240	COG1073	alpha beta
I6L02_RS18250	COG2814	Major facilitator Superfamily
I6L02_RS18255	COG2259	Doxx family
I6L02_RS18260	COG2017	converts alpha-aldose to the beta-anomer
I6L02_RS18265	COG1063	alcohol dehydrogenase
I6L02_RS18270	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS18275	COG1129	ABC transporter
I6L02_RS18280	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS18285	COG0457	Tetratricopeptide repeat
I6L02_RS18290	COG1940	carbohydrate kinase activity
I6L02_RS18300	COG1017	nitric oxide dioxygenase activity
I6L02_RS18300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L02_RS18305	COG0347	Belongs to the P(II) protein family
I6L02_RS18310	COG2204	response regulator
I6L02_RS18315	COG3170	Tfp pilus assembly protein FimV
I6L02_RS18320	COG2205	protein histidine kinase activity
I6L02_RS18325	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L02_RS18325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L02_RS18330	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L02_RS18335	COG0590	tRNA wobble adenosine to inosine editing
I6L02_RS18340	COG0560	Phosphoserine phosphatase
I6L02_RS18345	COG1737	Transcriptional regulator
I6L02_RS18350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS18365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L02_RS18385	COG0681	Belongs to the peptidase S26 family
I6L02_RS18395	COG3086	response to oxidative stress
I6L02_RS18400	COG3026	antisigma factor binding
I6L02_RS18405	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L02_RS18410	COG1595	DNA-templated transcription, initiation
I6L02_RS18420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L02_RS18430	COG0513	Belongs to the DEAD box helicase family
I6L02_RS18435	COG0583	DNA-binding transcription factor activity
I6L02_RS18455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L02_RS18460	COG3118	belongs to the thioredoxin family
I6L02_RS18465	COG3148	PFAM DTW domain containing protein
I6L02_RS18470	COG1042	CoA-binding domain protein
I6L02_RS18470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L02_RS18470	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L02_RS18475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L02_RS18480	COG5544	Lipoprotein
I6L02_RS18485	COG0477	Major facilitator Superfamily
I6L02_RS18520	COG0542	response to heat
I6L02_RS18530	COG0564	pseudouridine synthase activity
I6L02_RS18535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L02_RS18540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L02_RS18550	COG1605	Chorismate mutase
I6L02_RS18550	COG0077	Prephenate dehydratase
I6L02_RS18555	COG1605	Chorismate mutase
I6L02_RS18555	COG0287	Prephenate dehydrogenase
I6L02_RS18560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L02_RS18575	COG2199	diguanylate cyclase activity
I6L02_RS18580	COG2885	chlorophyll binding
I6L02_RS18605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L02_RS18610	COG4137	Cytochrome C assembly protein
I6L02_RS18615	COG4536	flavin adenine dinucleotide binding
I6L02_RS18630	COG0497	DNA recombination
I6L02_RS18635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L02_RS18645	COG2867	negative regulation of translational initiation
I6L02_RS18705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6L02_RS18810	COG4695	Portal protein
I6L02_RS18850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L02_RS18885	COG4974	Belongs to the 'phage' integrase family
I6L02_RS18900	COG0579	oxidoreductase
I6L02_RS18905	COG1012	belongs to the aldehyde dehydrogenase family
I6L02_RS18910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6L02_RS18915	COG1113	amino acid transport
I6L02_RS18920	COG1802	Transcriptional regulator
I6L02_RS18925	COG1652	LysM domain
I6L02_RS18930	COG0401	homolog of Blt101
I6L02_RS18935	COG0640	Transcriptional regulator
I6L02_RS18940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L02_RS18945	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L02_RS18960	COG4575	ribosome binding
I6L02_RS18970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L02_RS18975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L02_RS18985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L02_RS18990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L02_RS18995	COG4175	Glycine betaine
I6L02_RS19000	COG4176	ABC-type proline glycine betaine transport system permease component
I6L02_RS19005	COG2113	Glycine betaine
I6L02_RS19010	COG2814	Major facilitator Superfamily
I6L02_RS19015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6L02_RS19025	COG1846	Transcriptional regulator
I6L02_RS19030	COG1566	PFAM secretion protein HlyD family protein
I6L02_RS19035	COG2814	Major facilitator Superfamily
I6L02_RS19060	COG1238	metal cluster binding
I6L02_RS19065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L02_RS19095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L02_RS19115	COG1546	Belongs to the CinA family
I6L02_RS19120	COG2951	lytic endotransglycosylase activity
I6L02_RS19125	COG3730	PTS system glucitol sorbitol-specific
I6L02_RS19130	COG3732	PTS system glucitol sorbitol-specific
I6L02_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS19145	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS19150	COG1349	DNA-binding transcription factor activity
I6L02_RS19155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L02_RS19155	COG0517	IMP dehydrogenase activity
I6L02_RS19170	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L02_RS19175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L02_RS19180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS19185	COG1609	Transcriptional regulator
I6L02_RS19190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS19190	COG1263	PTS System
I6L02_RS19195	COG2723	6-phospho-beta-galactosidase activity
I6L02_RS19200	COG5499	transcription regulator containing HTH domain
I6L02_RS19210	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L02_RS19220	COG3260	NADH ubiquinone oxidoreductase 20
I6L02_RS19225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L02_RS19230	COG3261	NADH dehydrogenase
I6L02_RS19230	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L02_RS19235	COG0650	Formate hydrogenlyase subunit 4
I6L02_RS19240	COG0651	ATP synthesis coupled electron transport
I6L02_RS19245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS19255	COG0375	protein maturation
I6L02_RS19260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L02_RS19265	COG0298	carbon dioxide binding
I6L02_RS19270	COG0409	Hydrogenase expression formation protein
I6L02_RS19275	COG0309	Hydrogenase expression formation protein (HypE)
I6L02_RS19280	COG3604	Transcriptional regulator
I6L02_RS19295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L02_RS19300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L02_RS19305	COG1349	DNA-binding transcription factor activity
I6L02_RS19310	COG2084	Dehydrogenase
I6L02_RS19315	COG3395	kinase activity
I6L02_RS19320	COG0235	Class ii aldolase
I6L02_RS19325	COG3622	Belongs to the hyi family
I6L02_RS19330	COG2610	gluconate transmembrane transporter activity
I6L02_RS19345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L02_RS19350	COG4942	peptidase
I6L02_RS19350	COG1388	LysM domain
I6L02_RS19365	COG0585	pseudouridine synthase activity
I6L02_RS19405	COG2234	aminopeptidase activity
I6L02_RS19430	COG0720	synthase
I6L02_RS19435	COG0644	oxidoreductase
I6L02_RS19440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6L02_RS19445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6L02_RS19450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6L02_RS19455	COG2086	electron transfer activity
I6L02_RS19460	COG0477	Major facilitator Superfamily
I6L02_RS19465	COG0277	FAD linked oxidase domain protein
I6L02_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS19475	COG2223	nitrite transmembrane transporter activity
I6L02_RS19480	COG1070	Carbohydrate kinase
I6L02_RS19485	COG0602	queuosine metabolic process
I6L02_RS19495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L02_RS19505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L02_RS19520	COG3956	TIGRFAM MazG family protein
I6L02_RS19525	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6L02_RS19530	COG2336	PFAM SpoVT AbrB
I6L02_RS19535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L02_RS19545	COG3437	response regulator, receiver
I6L02_RS19545	COG2205	protein histidine kinase activity
I6L02_RS19545	COG3850	Histidine kinase
I6L02_RS19545	COG4999	Histidine kinase
I6L02_RS19550	COG4948	Mandelate Racemase Muconate Lactonizing
I6L02_RS19555	COG4948	Mandelate Racemase Muconate Lactonizing
I6L02_RS19560	COG2271	Major facilitator Superfamily
I6L02_RS19565	COG0716	FMN binding
I6L02_RS19570	COG0564	pseudouridine synthase activity
I6L02_RS19575	COG3098	single-species biofilm formation
I6L02_RS19590	COG1611	Belongs to the LOG family
I6L02_RS19595	COG0814	amino acid
I6L02_RS19600	COG1760	l-serine dehydratase
I6L02_RS19610	COG1454	alcohol dehydrogenase
I6L02_RS19615	COG0235	Class ii aldolase
I6L02_RS19620	COG0738	Major facilitator superfamily
I6L02_RS19630	COG1070	Carbohydrate kinase
I6L02_RS19640	COG1349	DNA-binding transcription factor activity
I6L02_RS19650	COG2363	Small membrane protein
I6L02_RS19655	COG0583	DNA-binding transcription factor activity
I6L02_RS19665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L02_RS19670	COG2166	iron-sulfur cluster assembly
I6L02_RS19675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L02_RS19680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L02_RS19700	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L02_RS19705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L02_RS19705	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L02_RS19710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L02_RS19715	COG1074	ATP-dependent DNA helicase activity
I6L02_RS19720	COG1025	Belongs to the peptidase M16 family
I6L02_RS19725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L02_RS19730	COG4967	type IV pilus modification protein PilV
I6L02_RS19740	COG4795	General secretion pathway protein
I6L02_RS19745	COG2165	general secretion pathway protein
I6L02_RS19760	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6L02_RS19775	COG0861	Integral membrane protein TerC family
I6L02_RS19785	COG0667	Aldo Keto reductase
I6L02_RS19800	COG1609	Transcriptional regulator
I6L02_RS19810	COG0583	DNA-binding transcription factor activity
I6L02_RS19815	COG1794	racemase activity, acting on amino acids and derivatives
I6L02_RS19820	COG2814	Major facilitator Superfamily
I6L02_RS19825	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS19835	COG0183	Belongs to the thiolase family
I6L02_RS19840	COG0814	amino acid
I6L02_RS19850	COG4942	peptidase
I6L02_RS19855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L02_RS19860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L02_RS19865	COG2080	2 iron, 2 sulfur cluster binding
I6L02_RS19870	COG3829	transcription factor binding
I6L02_RS19875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L02_RS19880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L02_RS19885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L02_RS19895	COG0549	Belongs to the carbamate kinase family
I6L02_RS19900	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L02_RS19900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L02_RS19905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L02_RS19910	COG2068	MobA-Related Protein
I6L02_RS19915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS19915	COG0493	'glutamate synthase
I6L02_RS19920	COG0402	S-adenosylhomocysteine deaminase activity
I6L02_RS19925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L02_RS19930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L02_RS19930	COG2080	2 iron, 2 sulfur cluster binding
I6L02_RS19935	COG2233	PERMEase
I6L02_RS19940	COG0402	S-adenosylhomocysteine deaminase activity
I6L02_RS19945	COG2252	PERMEase
I6L02_RS19950	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS19955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L02_RS19955	COG0493	'glutamate synthase
I6L02_RS19960	COG2233	PERMEase
I6L02_RS19980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L02_RS19990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L02_RS19995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L02_RS20000	COG4974	Belongs to the 'phage' integrase family
I6L02_RS20005	COG0716	FMN binding
I6L02_RS20015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L02_RS20025	COG1272	protein, Hemolysin III
I6L02_RS20035	COG2723	6-phospho-beta-galactosidase activity
I6L02_RS20040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L02_RS20040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L02_RS20060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L02_RS20065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L02_RS20070	COG0006	proline dipeptidase activity
I6L02_RS20090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L02_RS20100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L02_RS20120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6L02_RS20120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6L02_RS20125	COG0583	DNA-binding transcription factor activity
I6L02_RS20130	COG2968	Membrane
I6L02_RS20135	COG1279	arginine transmembrane transporter activity
I6L02_RS20140	COG0668	transmembrane transport
I6L02_RS20145	COG0191	fructose-bisphosphate aldolase activity
I6L02_RS20180	COG1122	ATPase activity
I6L02_RS20185	COG1072	(Pantothenic acid kinase))
I6L02_RS20200	COG1063	alcohol dehydrogenase
I6L02_RS20205	COG2213	PTS system mannitol-specific
I6L02_RS20210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS20215	COG0330	HflC and HflK could
I6L02_RS20220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L02_RS20225	COG0501	Belongs to the peptidase M48B family
I6L02_RS20240	COG1166	arginine decarboxylase activity
I6L02_RS20260	COG2814	Major facilitator Superfamily
I6L02_RS20270	COG2356	endonuclease I
I6L02_RS20275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L02_RS20280	COG0189	ligase activity
I6L02_RS20295	COG2805	Type II/IV secretion system protein
I6L02_RS20300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L02_RS20305	COG0762	integral membrane protein
I6L02_RS20315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L02_RS20320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L02_RS20330	COG0252	asparaginase activity
I6L02_RS20340	COG3171	Protein conserved in bacteria
I6L02_RS20350	COG1194	a g-specific adenine glycosylase
I6L02_RS20365	COG2211	Major facilitator Superfamily
I6L02_RS20370	COG1982	Orn Lys Arg decarboxylase major
I6L02_RS20375	COG1811	Na channel or pump
I6L02_RS20440	COG2089	acid synthase
I6L02_RS20460	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L02_RS20490	COG2165	general secretion pathway protein
I6L02_RS20495	COG1459	type II secretion system
I6L02_RS20500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L02_RS20530	COG1620	l-lactate permease
I6L02_RS20535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L02_RS20540	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6L02_RS20545	COG0247	lactate metabolic process
I6L02_RS20550	COG0277	FAD linked oxidase domain protein
I6L02_RS20555	COG0277	FAD linked oxidase domain protein
I6L02_RS20560	COG2186	Transcriptional regulator
I6L02_RS20565	COG0456	acetyltransferase
I6L02_RS20580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L02_RS20585	COG0156	8-amino-7-oxononanoate synthase activity
I6L02_RS20595	COG0795	lipopolysaccharide-transporting ATPase activity
I6L02_RS20600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L02_RS20610	COG2244	polysaccharide biosynthetic process
I6L02_RS20615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L02_RS20620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L02_RS20625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L02_RS20630	COG0306	phosphate transporter
I6L02_RS20635	COG0754	glutathionylspermidine amidase activity
I6L02_RS20640	COG0625	glutathione transferase activity
I6L02_RS20645	COG0298	carbon dioxide binding
I6L02_RS20650	COG0375	protein maturation
I6L02_RS20655	COG1773	rubredoxin
I6L02_RS20660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L02_RS20665	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L02_RS20670	COG5557	Pfam Polysulphide reductase, NrfD
I6L02_RS20675	COG0437	4 iron, 4 sulfur cluster binding
I6L02_RS20680	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L02_RS20695	COG0667	Aldo Keto reductase
I6L02_RS20705	COG1028	Short-chain dehydrogenase reductase Sdr
I6L02_RS20710	COG0848	biopolymer transport protein
I6L02_RS20715	COG0811	peptide transport
I6L02_RS20720	COG0626	cystathionine gamma-synthase activity
I6L02_RS20725	COG0586	Pfam SNARE associated Golgi protein
I6L02_RS20730	COG2207	Transcriptional regulator
I6L02_RS20735	COG1979	alcohol dehydrogenase
I6L02_RS20740	COG0656	L-ascorbic acid biosynthetic process
I6L02_RS20750	COG4238	major outer membrane lipoprotein
I6L02_RS20755	COG1032	radical SAM domain protein
I6L02_RS20760	COG2186	Transcriptional regulator
I6L02_RS20765	COG0246	Mannitol dehydrogenase
I6L02_RS20770	COG1063	alcohol dehydrogenase
I6L02_RS20775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6L02_RS20795	COG2132	Multicopper oxidase
I6L02_RS20800	COG0204	Acyl-transferase
I6L02_RS20805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6L02_RS20810	COG4166	transmembrane transport
I6L02_RS20815	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6L02_RS20820	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L02_RS20825	COG0745	RESPONSE REGULATOR receiver
I6L02_RS20830	COG0642	Histidine kinase
I6L02_RS20835	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L02_RS20840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6L02_RS20845	COG1737	Transcriptional regulator
I6L02_RS20855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS20860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L02_RS20865	COG1120	ATPase activity
I6L02_RS20870	COG4774	siderophore transport
I6L02_RS20875	COG0187	DNA topoisomerase II activity
I6L02_RS20880	COG3150	esterase
I6L02_RS20885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6L02_RS20890	COG3151	Protein conserved in bacteria
I6L02_RS20895	COG0494	nUDIX hydrolase
I6L02_RS20900	COG1538	Outer membrane efflux protein
I6L02_RS20910	COG0754	glutathionylspermidine amidase activity
I6L02_RS20920	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6L02_RS20930	COG3384	dioxygenase
I6L02_RS20945	COG3539	Fimbrial protein
I6L02_RS20950	COG3188	usher protein
I6L02_RS20955	COG3121	Chaperone
I6L02_RS20960	COG3539	Fimbrial protein
I6L02_RS20980	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L02_RS20985	COG2268	Band 7 protein
I6L02_RS21000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L02_RS21005	COG3025	triphosphatase activity
I6L02_RS21010	COG4991	sh3 domain protein
I6L02_RS21025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L02_RS21045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6L02_RS21050	COG0471	metal ion transport
I6L02_RS21060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L02_RS21065	COG0358	DNA primase activity
I6L02_RS21070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L02_RS21085	COG2375	cellular response to nickel ion
I6L02_RS21090	COG1695	Transcriptional regulator
I6L02_RS21095	COG0840	transmembrane signaling receptor activity
I6L02_RS21105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L02_RS21110	COG1609	Transcriptional regulator
I6L02_RS21115	COG3250	beta-galactosidase activity
I6L02_RS21120	COG2731	YhcH YjgK YiaL family protein
I6L02_RS21125	COG0531	amino acid
I6L02_RS21135	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L02_RS21135	COG3408	Glycogen debranching enzyme
I6L02_RS21140	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L02_RS21140	COG1902	pentaerythritol trinitrate reductase activity
I6L02_RS21145	COG5499	transcription regulator containing HTH domain
I6L02_RS21160	COG1451	nucleotide metabolic process
I6L02_RS21165	COG2949	membrane
I6L02_RS21170	COG0673	inositol 2-dehydrogenase activity
I6L02_RS21175	COG0861	Integral membrane protein TerC family
I6L02_RS21190	COG2721	sulfolactate sulfo-lyase activity
I6L02_RS21200	COG2271	Major facilitator Superfamily
I6L02_RS21205	COG2186	Transcriptional regulator
I6L02_RS21210	COG0586	Pfam SNARE associated Golgi protein
I6L02_RS21220	COG1422	Protein of unknown function (DUF1090)
I6L02_RS21225	COG4575	ribosome binding
I6L02_RS21230	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6L02_RS21240	COG2259	Doxx family
I6L02_RS21245	COG0435	Glutathione S-transferase
I6L02_RS21250	COG3152	Membrane
I6L02_RS21255	COG0583	DNA-binding transcription factor activity
I6L02_RS21260	COG1741	Belongs to the pirin family
I6L02_RS21275	COG0814	amino acid
I6L02_RS21280	COG1760	l-serine dehydratase
I6L02_RS21285	COG0251	oxidation-reduction process
I6L02_RS21290	COG1882	Formate acetyltransferase
I6L02_RS21295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L02_RS21305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L02_RS21310	COG0583	DNA-binding transcription factor activity
I6L02_RS21325	COG1929	Belongs to the glycerate kinase type-1 family
I6L02_RS21330	COG2084	Dehydrogenase
I6L02_RS21335	COG3836	Belongs to the HpcH HpaI aldolase family
I6L02_RS21340	COG2271	Major facilitator Superfamily
I6L02_RS21345	COG2721	sulfolactate sulfo-lyase activity
I6L02_RS21350	COG1349	DNA-binding transcription factor activity
I6L02_RS21360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS21370	COG3716	PTS system mannose fructose sorbose family IID component
I6L02_RS21375	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS21380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L02_RS21385	COG2222	sugar isomerase
I6L02_RS21395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L02_RS21400	COG3715	PTS system
I6L02_RS21405	COG3716	PTS system mannose fructose sorbose family IID component
I6L02_RS21410	COG0363	glucosamine-6-phosphate deaminase activity
I6L02_RS21415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L02_RS21435	COG2823	Periplasmic or secreted lipoprotein
I6L02_RS21440	COG0701	Predicted permease
I6L02_RS21445	COG0702	epimerase
I6L02_RS21450	COG0693	protein deglycase activity
I6L02_RS21465	COG3153	acetyltransferase
I6L02_RS21470	COG3154	lipid carrier protein
I6L02_RS21475	COG0826	peptidase U32
I6L02_RS21480	COG0826	peptidase U32
I6L02_RS21485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L02_RS21490	COG0814	amino acid
I6L02_RS21495	COG0513	Belongs to the DEAD box helicase family
I6L02_RS21535	COG0195	Participates in both transcription termination and antitermination
I6L02_RS21555	COG2194	sulfuric ester hydrolase activity
I6L02_RS21565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L02_RS21575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L02_RS21580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L02_RS21590	COG1534	Rna-binding protein
I6L02_RS21595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L02_RS21600	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L02_RS21610	COG0697	spore germination
I6L02_RS21625	COG0142	geranyltranstransferase activity
I6L02_RS21630	COG3423	Transcriptional regulator
I6L02_RS21640	COG5007	Belongs to the BolA IbaG family
I6L02_RS21645	COG3113	response to antibiotic
I6L02_RS21650	COG2854	intermembrane phospholipid transfer
I6L02_RS21655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L02_RS21660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L02_RS21665	COG1127	ABC transporter
I6L02_RS21670	COG0530	calcium, potassium:sodium antiporter activity
I6L02_RS21675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L02_RS21675	COG0517	IMP dehydrogenase activity
I6L02_RS21680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L02_RS21685	COG3117	lipopolysaccharide transmembrane transporter activity
I6L02_RS21690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L02_RS21695	COG1137	ATPase activity
I6L02_RS21700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L02_RS21705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L02_RS21720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L02_RS21725	COG0515	serine threonine protein kinase
I6L02_RS21735	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L02_RS21740	COG2198	Histidine kinase
I6L02_RS21740	COG0784	Response regulator, receiver
I6L02_RS21740	COG5002	protein histidine kinase activity
I6L02_RS21745	COG1242	4 iron, 4 sulfur cluster binding
I6L02_RS21750	COG0067	glutamate synthase
I6L02_RS21750	COG0069	glutamate synthase activity
I6L02_RS21750	COG0070	glutamate synthase
I6L02_RS21755	COG0493	'glutamate synthase
I6L02_RS21760	COG2731	YhcH YjgK YiaL family protein
I6L02_RS21765	COG1940	carbohydrate kinase activity
I6L02_RS21790	COG2969	positive regulation of protein catabolic process
I6L02_RS21795	COG0625	glutathione transferase activity
I6L02_RS21810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L02_RS21815	COG3105	Protein conserved in bacteria
I6L02_RS21820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L02_RS21825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L02_RS21845	COG2732	(Barnase) inhibitor
I6L02_RS21865	COG0583	DNA-binding transcription factor activity
I6L02_RS21870	COG0312	modulator of DNA gyrase
I6L02_RS21875	COG3164	Protein of unknown function
I6L02_RS21880	COG1530	ribonuclease E activity
I6L02_RS21890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L02_RS21895	COG1792	Involved in formation and maintenance of cell shape
I6L02_RS21900	COG1077	Cell shape determining protein MreB Mrl
I6L02_RS21905	COG2200	EAL domain
I6L02_RS21905	COG2199	diguanylate cyclase activity
I6L02_RS21910	COG0604	alcohol dehydrogenase
I6L02_RS21915	COG0511	ligase activity, forming carbon-carbon bonds
I6L02_RS21920	COG0439	Biotin carboxylase
I6L02_RS21930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS21935	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L02_RS21940	COG1129	ABC transporter
I6L02_RS21945	COG1879	ABC-type sugar transport system periplasmic component
I6L02_RS21955	COG1349	DNA-binding transcription factor activity
I6L02_RS21960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L02_RS21965	COG3924	membrane
I6L02_RS21970	COG4145	pantothenate transmembrane transporter activity
I6L02_RS21980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L02_RS21990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6L02_RS22000	COG1309	transcriptional regulator
I6L02_RS22005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L02_RS22010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L02_RS22020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L02_RS22025	COG4597	amino acid ABC transporter
I6L02_RS22030	COG0765	amino acid transport
I6L02_RS22035	COG1126	abc transporter atp-binding protein
I6L02_RS22075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L02_RS22090	COG0009	L-threonylcarbamoyladenylate synthase
I6L02_RS22095	COG0551	DNA topoisomerase type I activity
I6L02_RS22105	COG0758	DNA mediated transformation
I6L02_RS22125	COG0569	domain protein
I6L02_RS22135	COG3036	rescue of stalled ribosome
I6L02_RS22140	COG0789	Transcriptional regulator
I6L02_RS22180	COG0201	protein transport
I6L02_RS22270	COG0089	rRNA binding
I6L02_RS22295	COG3409	Peptidoglycan-binding domain 1 protein
I6L02_RS22295	COG3267	Type II secretory pathway component ExeA
I6L02_RS22300	COG3031	protein transport across the cell outer membrane
I6L02_RS22305	COG1450	Type ii and iii secretion system protein
I6L02_RS22310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L02_RS22315	COG1459	type II secretion system
I6L02_RS22320	COG2165	general secretion pathway protein
I6L02_RS22325	COG2165	general secretion pathway protein
I6L02_RS22330	COG2165	general secretion pathway protein
I6L02_RS22335	COG4795	General secretion pathway protein
I6L02_RS22340	COG3156	type II secretion system protein K
I6L02_RS22345	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L02_RS22350	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L02_RS22355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6L02_RS22360	COG2193	ferroxidase activity
I6L02_RS22365	COG2906	2 iron, 2 sulfur cluster binding
I6L02_RS22370	COG3979	chitinase
I6L02_RS22430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L02_RS22495	COG2948	multi-organism process
I6L02_RS22600	COG2026	Addiction module toxin, RelE StbE family
I6L02_RS22660	COG0672	)-iron permease
I6L02_RS22665	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L02_RS22670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L02_RS22950	COG1475	DNA binding
I6L02_RS23150	COG4771	TonB-dependent receptor
I6L02_RS23180	COG3436	PFAM IS66 Orf2 family protein
I6L02_RS23195	COG3344	reverse transcriptase
I6L02_RS23260	COG1484	DNA-dependent DNA replication
I6L02_RS23265	COG4584	PFAM Integrase catalytic
I6L02_RS23300	COG0577	efflux transmembrane transporter activity
I6L02_RS23300	COG1136	(ABC) transporter
I6L02_RS23305	COG0577	efflux transmembrane transporter activity
I6L02_RS23305	COG1136	(ABC) transporter