locus-tag	class	description
RG45_RS00010	COG4206	TonB-dependent receptor
RG45_RS00025	COG1309	transcriptional regulator
RG45_RS00040	COG0583	DNA-binding transcription factor activity
RG45_RS00055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RG45_RS00070	COG2194	sulfuric ester hydrolase activity
RG45_RS00080	COG2207	Transcriptional regulator
RG45_RS00085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS00090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG45_RS00095	COG1882	Formate acetyltransferase
RG45_RS00100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS00105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS00110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS00110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS00110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG45_RS00115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG45_RS00120	COG0371	Dehydrogenase
RG45_RS00130	COG3738	Protein conserved in bacteria
RG45_RS00135	COG0697	spore germination
RG45_RS00145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RG45_RS00155	COG0460	homoserine dehydrogenase
RG45_RS00155	COG0527	aspartate kinase activity
RG45_RS00160	COG0626	cystathionine gamma-synthase activity
RG45_RS00170	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RG45_RS00185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RG45_RS00190	COG1609	Transcriptional regulator
RG45_RS00195	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG45_RS00210	COG1575	Belongs to the MenA family. Type 1 subfamily
RG45_RS00225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RG45_RS00235	COG1494	fructose-1,6-bisphosphatase
RG45_RS00240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG45_RS00245	COG0589	response to stress
RG45_RS00250	COG3691	Protein conserved in bacteria
RG45_RS00255	COG3152	Membrane
RG45_RS00280	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RG45_RS00300	COG3678	ATP-independent chaperone mediated protein folding
RG45_RS00305	COG0745	RESPONSE REGULATOR receiver
RG45_RS00310	COG2205	protein histidine kinase activity
RG45_RS00315	COG2258	MOSC domain
RG45_RS00335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG45_RS00380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS00385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS00385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS00390	COG1363	Peptidase, m42
RG45_RS00395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS00395	COG3711	transcriptional antiterminator
RG45_RS00435	COG3383	formate dehydrogenase (NAD+) activity
RG45_RS00435	COG0243	molybdopterin cofactor binding
RG45_RS00440	COG0243	molybdopterin cofactor binding
RG45_RS00440	COG3383	formate dehydrogenase (NAD+) activity
RG45_RS00445	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS00450	COG2864	formate dehydrogenase
RG45_RS00465	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG45_RS00470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG45_RS00495	COG0456	acetyltransferase
RG45_RS00510	COG1011	Hydrolase
RG45_RS00545	COG2271	Major facilitator Superfamily
RG45_RS00550	COG1082	Xylose isomerase domain protein TIM barrel
RG45_RS00555	COG2188	Transcriptional regulator
RG45_RS00560	COG1217	gtp-binding protein TYPA
RG45_RS00570	COG0174	glutamine synthetase
RG45_RS00575	COG3852	Histidine kinase
RG45_RS00580	COG2204	response regulator
RG45_RS00590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG45_RS00595	COG3078	GTPase activator activity
RG45_RS00610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG45_RS00610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG45_RS00620	COG0204	Acyl-transferase
RG45_RS00625	COG5339	Protein conserved in bacteria
RG45_RS00645	COG5339	Protein conserved in bacteria
RG45_RS00650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG45_RS00655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RG45_RS00660	COG3084	Protein conserved in bacteria
RG45_RS00665	COG0746	molybdenum cofactor guanylyltransferase activity
RG45_RS00670	COG1763	Mo-molybdopterin cofactor biosynthetic process
RG45_RS00700	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
RG45_RS00705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG45_RS00710	COG1739	Uncharacterized protein family UPF0029
RG45_RS00735	COG0543	2 iron, 2 sulfur cluster binding
RG45_RS00745	COG0250	Participates in transcription elongation, termination and antitermination
RG45_RS00750	COG0084	hydrolase, TatD family'
RG45_RS00755	COG0805	protein transport
RG45_RS00760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG45_RS00765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG45_RS00775	COG3165	ubiquinone biosynthetic process from chorismate
RG45_RS00785	COG1322	Protein conserved in bacteria
RG45_RS00795	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RG45_RS00800	COG0412	Dienelactone hydrolase
RG45_RS00810	COG0583	DNA-binding transcription factor activity
RG45_RS00815	COG0697	spore germination
RG45_RS00820	COG0561	phosphatase activity
RG45_RS00825	COG2267	carboxylic ester hydrolase activity
RG45_RS00830	COG1280	lysine exporter protein (LysE YggA)
RG45_RS00835	COG1280	lysine exporter protein (LysE YggA)
RG45_RS00840	COG0514	ATP-dependent DNA helicase (RecQ)
RG45_RS00845	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RG45_RS00850	COG2050	protein possibly involved in aromatic compounds catabolism
RG45_RS00855	COG2962	Rard protein
RG45_RS00870	COG0598	Magnesium transport protein CorA
RG45_RS00880	COG3698	Phosphodiester glycosidase
RG45_RS00885	COG0210	DNA helicase
RG45_RS00890	COG1011	Hydrolase
RG45_RS00900	COG3159	Protein conserved in bacteria
RG45_RS00910	COG5567	small periplasmic lipoprotein
RG45_RS00935	COG3072	Adenylate cyclase
RG45_RS00950	COG1587	Uroporphyrinogen-III synthase
RG45_RS00955	COG2959	enzyme of heme biosynthesis
RG45_RS00960	COG3071	HemY protein
RG45_RS00965	COG3119	arylsulfatase activity
RG45_RS00970	COG0641	radical SAM
RG45_RS00995	COG1113	amino acid transport
RG45_RS01015	COG2244	polysaccharide biosynthetic process
RG45_RS01020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RG45_RS01025	COG0456	acetyltransferase
RG45_RS01030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG45_RS01035	COG1088	dTDP-glucose 4,6-dehydratase activity
RG45_RS01040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RG45_RS01045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RG45_RS01050	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG45_RS01055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RG45_RS01065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RG45_RS01075	COG3118	belongs to the thioredoxin family
RG45_RS01095	COG0210	DNA helicase
RG45_RS01100	COG3692	DNA binding
RG45_RS01105	COG3692	DNA binding
RG45_RS01110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG45_RS01120	COG0583	DNA-binding transcription factor activity
RG45_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG45_RS01135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG45_RS01140	COG3978	acetolactate synthase activity
RG45_RS01155	COG0606	chelatase, subunit chli
RG45_RS01160	COG3085	chromosome segregation
RG45_RS01205	COG2186	Transcriptional regulator
RG45_RS01210	COG0477	Major facilitator Superfamily
RG45_RS01215	COG1609	Transcriptional regulator
RG45_RS01220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS01225	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS01230	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG45_RS01235	COG1129	ABC transporter
RG45_RS01265	COG1522	sequence-specific DNA binding
RG45_RS01270	COG0716	FMN binding
RG45_RS01285	COG3312	ion transport
RG45_RS01335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RG45_RS01340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG45_RS01345	COG0573	inorganic phosphate transmembrane transporter activity
RG45_RS01350	COG0581	inorganic phosphate transmembrane transporter activity
RG45_RS01355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RG45_RS01360	COG0704	Plays a role in the regulation of phosphate uptake
RG45_RS01365	COG3711	transcriptional antiterminator
RG45_RS01370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS01370	COG2190	(PTS) system
RG45_RS01370	COG1263	PTS System
RG45_RS01375	COG2723	6-phospho-beta-galactosidase activity
RG45_RS01385	COG2382	esterase
RG45_RS01390	COG0363	glucosamine-6-phosphate deaminase activity
RG45_RS01395	COG3196	Protein conserved in bacteria
RG45_RS01420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG45_RS01425	COG2252	PERMEase
RG45_RS01430	COG0431	NADPH-dependent FMN reductase
RG45_RS01435	COG2091	lysine biosynthetic process via aminoadipic acid
RG45_RS01450	COG0814	amino acid
RG45_RS01500	COG0592	DNA-directed DNA polymerase activity
RG45_RS01510	COG0187	DNA topoisomerase II activity
RG45_RS01515	COG3753	Protein conserved in bacteria
RG45_RS01520	COG0561	phosphatase activity
RG45_RS01530	COG2186	Transcriptional regulator
RG45_RS01535	COG3734	2-keto-3-deoxy-galactonokinase
RG45_RS01540	COG0800	Aldolase
RG45_RS01550	COG2271	Major facilitator Superfamily
RG45_RS01560	COG0823	Involved in the tonB-independent uptake of proteins
RG45_RS01565	COG5645	(Lipo)protein
RG45_RS01590	COG2188	Transcriptional regulator
RG45_RS01605	COG2207	Transcriptional regulator
RG45_RS01615	COG0675	Transposase, IS605 OrfB family
RG45_RS01620	COG2149	membrane
RG45_RS01630	COG0641	radical SAM
RG45_RS01635	COG2814	Major facilitator Superfamily
RG45_RS01670	COG0028	Belongs to the TPP enzyme family
RG45_RS01675	COG0440	acetolactate synthase activity
RG45_RS01680	COG2197	response regulator
RG45_RS01685	COG3851	Histidine kinase
RG45_RS01690	COG2271	Major facilitator Superfamily
RG45_RS01695	COG2271	Major facilitator Superfamily
RG45_RS01705	COG2252	PERMEase
RG45_RS01740	COG1464	Belongs to the NlpA lipoprotein family
RG45_RS01745	COG0697	spore germination
RG45_RS01750	COG2814	Major facilitator Superfamily
RG45_RS01765	COG2211	Major facilitator Superfamily
RG45_RS01790	COG2211	Major facilitator Superfamily
RG45_RS01800	COG2982	Protein involved in outer membrane biogenesis
RG45_RS01805	COG2233	PERMEase
RG45_RS01810	COG0786	glutamate:sodium symporter activity
RG45_RS01815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RG45_RS01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG45_RS01825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG45_RS01835	COG0194	GDP metabolic process
RG45_RS01845	COG2860	membrane
RG45_RS01855	COG1561	YicC-like family, N-terminal region
RG45_RS01885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RG45_RS01915	COG1519	Transferase
RG45_RS01920	COG0859	PFAM glycosyl transferase family 9
RG45_RS01925	COG0438	transferase activity, transferring glycosyl groups
RG45_RS01930	COG0515	serine threonine protein kinase
RG45_RS01945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RG45_RS01950	COG1442	glycosyl transferase family 8
RG45_RS01955	COG1216	Glycosyl transferase, family 2
RG45_RS01960	COG3307	-O-antigen
RG45_RS01965	COG0859	PFAM glycosyl transferase family 9
RG45_RS01970	COG0859	PFAM glycosyl transferase family 9
RG45_RS01980	COG0156	8-amino-7-oxononanoate synthase activity
RG45_RS01990	COG1216	Glycosyl transferase, family 2
RG45_RS01995	COG2861	carbohydrate metabolic process
RG45_RS02000	COG4942	peptidase
RG45_RS02015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG45_RS02020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG45_RS02035	COG1045	serine acetyltransferase
RG45_RS02040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RG45_RS02050	COG2186	Transcriptional regulator
RG45_RS02055	COG1620	l-lactate permease
RG45_RS02065	COG5295	Hep Hag repeat protein
RG45_RS02090	COG3722	fumarate hydratase activity
RG45_RS02100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS02100	COG2213	PTS system mannitol-specific
RG45_RS02110	COG1566	PFAM secretion protein HlyD family protein
RG45_RS02135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG45_RS02140	COG3209	COG3209 Rhs family protein
RG45_RS02145	COG1413	lyase activity
RG45_RS02155	COG0625	glutathione transferase activity
RG45_RS02165	COG3276	selenocysteine insertion sequence binding
RG45_RS02175	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS02190	COG1566	PFAM secretion protein HlyD family protein
RG45_RS02195	COG0583	DNA-binding transcription factor activity
RG45_RS02200	COG3713	MltA-interacting MipA family protein
RG45_RS02205	COG0235	Class ii aldolase
RG45_RS02210	COG3623	hexulose-6-phosphate isomerase
RG45_RS02215	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RG45_RS02220	COG1070	Carbohydrate kinase
RG45_RS02225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG45_RS02230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RG45_RS02235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG45_RS02240	COG2731	YhcH YjgK YiaL family protein
RG45_RS02250	COG1414	Transcriptional regulator
RG45_RS02255	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS02260	COG3977	Valine--pyruvate aminotransferase
RG45_RS02265	COG0366	Alpha amylase catalytic
RG45_RS02270	COG2992	FlgJ-related protein
RG45_RS02275	COG1609	Transcriptional regulator
RG45_RS02275	COG2207	Transcriptional regulator
RG45_RS02280	COG4214	carbohydrate transport
RG45_RS02285	COG1129	ABC transporter
RG45_RS02290	COG4213	ABC transporter substrate-binding protein
RG45_RS02300	COG1070	Carbohydrate kinase
RG45_RS02305	COG4682	membrane
RG45_RS02310	COG4682	membrane
RG45_RS02315	COG3274	enterobacterial common antigen metabolic process
RG45_RS02335	COG2801	Transposase and inactivated derivatives
RG45_RS02340	COG2963	transposase activity
RG45_RS02345	COG1278	Cold shock
RG45_RS02350	COG2944	sequence-specific DNA binding
RG45_RS02365	COG2885	chlorophyll binding
RG45_RS02370	COG0243	molybdopterin cofactor binding
RG45_RS02375	COG0456	acetyltransferase
RG45_RS02380	COG2818	Glycosylase
RG45_RS02385	COG5571	outer membrane autotransporter
RG45_RS02395	COG2223	nitrite transmembrane transporter activity
RG45_RS02400	COG2194	sulfuric ester hydrolase activity
RG45_RS02420	COG0747	negative chemotaxis
RG45_RS02430	COG0601	transmembrane transport
RG45_RS02435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG45_RS02440	COG0444	Belongs to the ABC transporter superfamily
RG45_RS02445	COG4608	Belongs to the ABC transporter superfamily
RG45_RS02450	COG0814	amino acid
RG45_RS02490	COG2194	sulfuric ester hydrolase activity
RG45_RS02535	COG1215	transferase activity, transferring glycosyl groups
RG45_RS02540	COG1215	transferase activity, transferring glycosyl groups
RG45_RS02545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RG45_RS02550	COG3118	belongs to the thioredoxin family
RG45_RS02550	COG0457	Tetratricopeptide repeat
RG45_RS02555	COG2199	diguanylate cyclase activity
RG45_RS02555	COG2200	EAL domain
RG45_RS02575	COG0612	Peptidase, M16
RG45_RS02580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS02590	COG2200	EAL domain
RG45_RS02595	COG2982	Protein involved in outer membrane biogenesis
RG45_RS02600	COG0477	Major facilitator Superfamily
RG45_RS02605	COG1295	ribonuclease BN
RG45_RS02610	COG0583	DNA-binding transcription factor activity
RG45_RS02615	COG2197	response regulator
RG45_RS02625	COG1858	cytochrome C peroxidase
RG45_RS02630	COG0076	glutamate decarboxylase activity
RG45_RS02635	COG2207	Transcriptional regulator
RG45_RS02640	COG2207	Transcriptional regulator
RG45_RS02650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG45_RS02655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS02665	COG2771	luxR family
RG45_RS02670	COG3247	response to pH
RG45_RS02685	COG1285	pathogenesis
RG45_RS02690	COG2197	response regulator
RG45_RS02700	COG3065	identical protein binding
RG45_RS02710	COG1393	Belongs to the ArsC family
RG45_RS02715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG45_RS02720	COG0640	Transcriptional regulator
RG45_RS02735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG45_RS02740	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RG45_RS02745	COG0339	signal peptide processing
RG45_RS02755	COG3104	oligopeptide transport
RG45_RS02765	COG0589	response to stress
RG45_RS02775	COG0306	phosphate transporter
RG45_RS02780	COG2081	HI0933 family
RG45_RS02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS02820	COG1129	ABC transporter
RG45_RS02820	COG0842	Transport permease protein
RG45_RS02825	COG0842	Transport permease protein
RG45_RS02835	COG1413	lyase activity
RG45_RS02850	COG3209	COG3209 Rhs family protein
RG45_RS02865	COG0444	Belongs to the ABC transporter superfamily
RG45_RS02870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG45_RS02875	COG0601	transmembrane transport
RG45_RS02880	COG0747	negative chemotaxis
RG45_RS02885	COG2091	lysine biosynthetic process via aminoadipic acid
RG45_RS02890	COG0628	permease
RG45_RS02905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RG45_RS02920	COG3714	YhhN family
RG45_RS02930	COG3776	membrane
RG45_RS02935	COG0742	ribosomal rna small subunit methyltransferase
RG45_RS02940	COG0552	protein localization to endoplasmic reticulum
RG45_RS02945	COG2884	Cell division ATP-binding protein ftsE
RG45_RS02950	COG2177	Part of the ABC transporter FtsEX involved in
RG45_RS02955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG45_RS02960	COG0683	leucine binding
RG45_RS02965	COG0456	acetyltransferase
RG45_RS02975	COG0683	leucine binding
RG45_RS02980	COG0559	Belongs to the binding-protein-dependent transport system permease family
RG45_RS02985	COG4177	L-phenylalanine transmembrane transporter activity
RG45_RS02990	COG0411	ABC transporter
RG45_RS02995	COG0410	ABC transporter
RG45_RS03005	COG1653	transport
RG45_RS03010	COG1175	transmembrane transport
RG45_RS03020	COG3842	ATPase activity
RG45_RS03025	COG0584	glycerophosphoryl diester phosphodiesterase
RG45_RS03035	COG0405	Gamma-glutamyltransferase
RG45_RS03065	COG1247	-acetyltransferase
RG45_RS03070	COG0673	inositol 2-dehydrogenase activity
RG45_RS03075	COG1741	Belongs to the pirin family
RG45_RS03080	COG1609	Transcriptional regulator
RG45_RS03085	COG3265	gluconokinase activity
RG45_RS03090	COG2610	gluconate transmembrane transporter activity
RG45_RS03095	COG2095	MarC family integral membrane protein
RG45_RS03100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG45_RS03125	COG0058	SHG alpha-glucan phosphorylase activity
RG45_RS03130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG45_RS03145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG45_RS03160	COG1349	DNA-binding transcription factor activity
RG45_RS03165	COG4650	regulator
RG45_RS03170	COG1690	Belongs to the RtcB family
RG45_RS03185	COG0058	SHG alpha-glucan phosphorylase activity
RG45_RS03190	COG1640	4-alpha-glucanotransferase
RG45_RS03195	COG2610	gluconate transmembrane transporter activity
RG45_RS03215	COG5464	transposase or invertase
RG45_RS03230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RG45_RS03235	COG1918	ferrous iron import across plasma membrane
RG45_RS03245	COG2183	response to ionizing radiation
RG45_RS03250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG45_RS03280	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG45_RS03290	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RG45_RS03295	COG1011	Hydrolase
RG45_RS03305	COG0494	nUDIX hydrolase
RG45_RS03310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RG45_RS03320	COG3166	PFAM Fimbrial assembly family protein
RG45_RS03335	COG4796	Type ii and iii secretion system protein
RG45_RS03350	COG3266	domain, Protein
RG45_RS03355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RG45_RS03360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG45_RS03365	COG0546	phosphoglycolate phosphatase activity
RG45_RS03370	COG0180	Tryptophanyl-tRNA synthetase
RG45_RS03380	COG2188	Transcriptional regulator
RG45_RS03390	COG3457	Alanine racemase
RG45_RS03395	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RG45_RS03400	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RG45_RS03415	COG0626	cystathionine gamma-synthase activity
RG45_RS03420	COG2188	Transcriptional regulator
RG45_RS03425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS03430	COG1082	Xylose isomerase domain protein TIM barrel
RG45_RS03435	COG1082	Xylose isomerase domain protein TIM barrel
RG45_RS03440	COG2222	sugar isomerase
RG45_RS03445	COG0531	amino acid
RG45_RS03460	COG2116	formate transmembrane transporter activity
RG45_RS03465	COG2146	nitrite reductase [NAD(P)H] activity
RG45_RS03470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG45_RS03485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG45_RS03495	COG2184	nucleotidyltransferase activity
RG45_RS03500	COG0512	Glutamine amidotransferase of anthranilate synthase
RG45_RS03505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RG45_RS03510	COG1289	transmembrane transporter activity
RG45_RS03515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG45_RS03525	COG1765	OsmC-like protein
RG45_RS03530	COG3954	Phosphoribulokinase
RG45_RS03540	COG0429	hydrolase of the alpha beta-hydrolase fold
RG45_RS03545	COG0488	(ABC) transporter
RG45_RS03565	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RG45_RS03570	COG1047	Peptidyl-prolyl cis-trans
RG45_RS03580	COG0545	Peptidyl-prolyl cis-trans isomerase
RG45_RS03585	COG2964	Protein conserved in bacteria
RG45_RS03625	COG3979	chitinase
RG45_RS03630	COG2906	2 iron, 2 sulfur cluster binding
RG45_RS03635	COG2193	ferroxidase activity
RG45_RS03640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RG45_RS03645	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG45_RS03650	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG45_RS03655	COG3156	type II secretion system protein K
RG45_RS03660	COG4795	General secretion pathway protein
RG45_RS03665	COG2165	general secretion pathway protein
RG45_RS03670	COG2165	general secretion pathway protein
RG45_RS03680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG45_RS03685	COG1450	Type ii and iii secretion system protein
RG45_RS03695	COG3409	Peptidoglycan-binding domain 1 protein
RG45_RS03695	COG3267	Type II secretory pathway component ExeA
RG45_RS03720	COG0089	rRNA binding
RG45_RS03810	COG0201	protein transport
RG45_RS03850	COG0789	Transcriptional regulator
RG45_RS03855	COG3036	rescue of stalled ribosome
RG45_RS03865	COG0569	domain protein
RG45_RS03885	COG0758	DNA mediated transformation
RG45_RS03895	COG0551	DNA topoisomerase type I activity
RG45_RS03915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG45_RS03955	COG1126	abc transporter atp-binding protein
RG45_RS03960	COG0765	amino acid transport
RG45_RS03965	COG4597	amino acid ABC transporter
RG45_RS03970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS03980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG45_RS03985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS04010	COG1309	transcriptional regulator
RG45_RS04020	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RG45_RS04030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG45_RS04040	COG4145	pantothenate transmembrane transporter activity
RG45_RS04045	COG3924	membrane
RG45_RS04050	COG0439	Biotin carboxylase
RG45_RS04055	COG0511	ligase activity, forming carbon-carbon bonds
RG45_RS04075	COG0604	alcohol dehydrogenase
RG45_RS04080	COG2200	EAL domain
RG45_RS04080	COG2199	diguanylate cyclase activity
RG45_RS04095	COG1077	Cell shape determining protein MreB Mrl
RG45_RS04100	COG1792	Involved in formation and maintenance of cell shape
RG45_RS04105	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RG45_RS04110	COG0424	maF-like protein
RG45_RS04115	COG1530	ribonuclease E activity
RG45_RS04120	COG3164	Protein of unknown function
RG45_RS04130	COG0312	modulator of DNA gyrase
RG45_RS04135	COG0583	DNA-binding transcription factor activity
RG45_RS04155	COG2732	(Barnase) inhibitor
RG45_RS04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG45_RS04180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG45_RS04185	COG3105	Protein conserved in bacteria
RG45_RS04190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RG45_RS04205	COG0625	glutathione transferase activity
RG45_RS04210	COG2969	positive regulation of protein catabolic process
RG45_RS04215	COG3069	C4-dicarboxylate transmembrane transporter activity
RG45_RS04250	COG2731	YhcH YjgK YiaL family protein
RG45_RS04260	COG4804	nuclease activity
RG45_RS04265	COG0493	'glutamate synthase
RG45_RS04270	COG0069	glutamate synthase activity
RG45_RS04270	COG0067	glutamate synthase
RG45_RS04270	COG0070	glutamate synthase
RG45_RS04285	COG1242	4 iron, 4 sulfur cluster binding
RG45_RS04290	COG2198	Histidine kinase
RG45_RS04290	COG0784	Response regulator, receiver
RG45_RS04290	COG5002	protein histidine kinase activity
RG45_RS04295	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RG45_RS04305	COG0515	serine threonine protein kinase
RG45_RS04310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS04325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG45_RS04330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RG45_RS04335	COG1137	ATPase activity
RG45_RS04340	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RG45_RS04345	COG3117	lipopolysaccharide transmembrane transporter activity
RG45_RS04350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RG45_RS04355	COG0517	IMP dehydrogenase activity
RG45_RS04355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG45_RS04360	COG0530	calcium, potassium:sodium antiporter activity
RG45_RS04365	COG1127	ABC transporter
RG45_RS04370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RG45_RS04375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG45_RS04380	COG2854	intermembrane phospholipid transfer
RG45_RS04385	COG3113	response to antibiotic
RG45_RS04390	COG5007	Belongs to the BolA IbaG family
RG45_RS04400	COG3423	Transcriptional regulator
RG45_RS04405	COG0142	geranyltranstransferase activity
RG45_RS04420	COG0697	spore germination
RG45_RS04435	COG2027	D-alanyl-D-alanine carboxypeptidase
RG45_RS04440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG45_RS04445	COG1534	Rna-binding protein
RG45_RS04455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG45_RS04460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RG45_RS04470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG45_RS04485	COG2194	sulfuric ester hydrolase activity
RG45_RS04505	COG0195	Participates in both transcription termination and antitermination
RG45_RS04545	COG0513	Belongs to the DEAD box helicase family
RG45_RS04555	COG0814	amino acid
RG45_RS04560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RG45_RS04565	COG0826	peptidase U32
RG45_RS04570	COG0826	peptidase U32
RG45_RS04575	COG3154	lipid carrier protein
RG45_RS04580	COG3153	acetyltransferase
RG45_RS04595	COG0693	protein deglycase activity
RG45_RS04600	COG0702	epimerase
RG45_RS04605	COG0701	Predicted permease
RG45_RS04610	COG2823	Periplasmic or secreted lipoprotein
RG45_RS04625	COG3107	peptidoglycan biosynthetic process
RG45_RS04630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RG45_RS04635	COG3539	Fimbrial protein
RG45_RS04640	COG3188	usher protein
RG45_RS04645	COG3121	Chaperone
RG45_RS04650	COG3539	Fimbrial protein
RG45_RS04670	COG3539	Fimbrial protein
RG45_RS04675	COG0363	glucosamine-6-phosphate deaminase activity
RG45_RS04680	COG3716	PTS system mannose fructose sorbose family IID component
RG45_RS04685	COG3715	PTS system
RG45_RS04690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS04700	COG2222	sugar isomerase
RG45_RS04705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG45_RS04710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS04715	COG3716	PTS system mannose fructose sorbose family IID component
RG45_RS04725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS04740	COG1349	DNA-binding transcription factor activity
RG45_RS04750	COG2002	toxin-antitoxin pair type II binding
RG45_RS04755	COG2721	sulfolactate sulfo-lyase activity
RG45_RS04760	COG2271	Major facilitator Superfamily
RG45_RS04770	COG2084	Dehydrogenase
RG45_RS04775	COG1929	Belongs to the glycerate kinase type-1 family
RG45_RS04805	COG0583	DNA-binding transcription factor activity
RG45_RS04810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG45_RS04820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG45_RS04825	COG1882	Formate acetyltransferase
RG45_RS04830	COG0251	oxidation-reduction process
RG45_RS04835	COG1760	l-serine dehydratase
RG45_RS04840	COG0814	amino acid
RG45_RS04855	COG1741	Belongs to the pirin family
RG45_RS04860	COG0583	DNA-binding transcription factor activity
RG45_RS04885	COG3152	Membrane
RG45_RS04890	COG3152	Membrane
RG45_RS04895	COG0435	Glutathione S-transferase
RG45_RS04900	COG2259	Doxx family
RG45_RS04910	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
RG45_RS04915	COG4575	ribosome binding
RG45_RS04920	COG1422	Protein of unknown function (DUF1090)
RG45_RS04930	COG0586	Pfam SNARE associated Golgi protein
RG45_RS04935	COG2186	Transcriptional regulator
RG45_RS04940	COG2271	Major facilitator Superfamily
RG45_RS04950	COG2721	sulfolactate sulfo-lyase activity
RG45_RS04960	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RG45_RS04965	COG0861	Integral membrane protein TerC family
RG45_RS04970	COG0673	inositol 2-dehydrogenase activity
RG45_RS04975	COG2949	membrane
RG45_RS04980	COG1451	nucleotide metabolic process
RG45_RS04995	COG4680	protein conserved in bacteria
RG45_RS05000	COG5499	transcription regulator containing HTH domain
RG45_RS05005	COG0446	pyridine nucleotide-disulphide oxidoreductase
RG45_RS05005	COG1902	pentaerythritol trinitrate reductase activity
RG45_RS05010	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RG45_RS05010	COG3408	Glycogen debranching enzyme
RG45_RS05020	COG0531	amino acid
RG45_RS05025	COG2731	YhcH YjgK YiaL family protein
RG45_RS05030	COG3250	beta-galactosidase activity
RG45_RS05035	COG1609	Transcriptional regulator
RG45_RS05045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG45_RS05060	COG0840	transmembrane signaling receptor activity
RG45_RS05065	COG1695	Transcriptional regulator
RG45_RS05075	COG2375	cellular response to nickel ion
RG45_RS05090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG45_RS05100	COG0358	DNA primase activity
RG45_RS05105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RG45_RS05120	COG0471	metal ion transport
RG45_RS05125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG45_RS05130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG45_RS05140	COG0583	DNA-binding transcription factor activity
RG45_RS05150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG45_RS05165	COG4991	sh3 domain protein
RG45_RS05175	COG3025	triphosphatase activity
RG45_RS05215	COG2801	Transposase and inactivated derivatives
RG45_RS05220	COG2963	transposase activity
RG45_RS05230	COG2268	Band 7 protein
RG45_RS05235	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG45_RS05245	COG3539	Fimbrial protein
RG45_RS05250	COG3121	Chaperone
RG45_RS05255	COG3188	usher protein
RG45_RS05260	COG3539	Fimbrial protein
RG45_RS05265	COG2960	long-chain fatty acid transporting porin activity
RG45_RS05285	COG3384	dioxygenase
RG45_RS05290	COG0754	glutathionylspermidine amidase activity
RG45_RS05305	COG1538	Outer membrane efflux protein
RG45_RS05310	COG0494	nUDIX hydrolase
RG45_RS05315	COG3151	Protein conserved in bacteria
RG45_RS05320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RG45_RS05325	COG3150	esterase
RG45_RS05330	COG0187	DNA topoisomerase II activity
RG45_RS05335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RG45_RS05340	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG45_RS05350	COG0642	Histidine kinase
RG45_RS05355	COG0745	RESPONSE REGULATOR receiver
RG45_RS05360	COG3111	PFAM Bacterial OB fold (BOF) protein
RG45_RS05365	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG45_RS05375	COG2944	sequence-specific DNA binding
RG45_RS05380	COG4166	transmembrane transport
RG45_RS05385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG45_RS05395	COG0204	Acyl-transferase
RG45_RS05400	COG2132	Multicopper oxidase
RG45_RS05405	COG1032	radical SAM domain protein
RG45_RS05410	COG4238	major outer membrane lipoprotein
RG45_RS05420	COG0656	L-ascorbic acid biosynthetic process
RG45_RS05425	COG1979	alcohol dehydrogenase
RG45_RS05435	COG2207	Transcriptional regulator
RG45_RS05440	COG0586	Pfam SNARE associated Golgi protein
RG45_RS05445	COG0626	cystathionine gamma-synthase activity
RG45_RS05455	COG0811	peptide transport
RG45_RS05460	COG0848	biopolymer transport protein
RG45_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS05480	COG0667	Aldo Keto reductase
RG45_RS05500	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG45_RS05505	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS05510	COG5557	Pfam Polysulphide reductase, NrfD
RG45_RS05515	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG45_RS05520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG45_RS05525	COG1773	rubredoxin
RG45_RS05535	COG0298	carbon dioxide binding
RG45_RS05545	COG0754	glutathionylspermidine amidase activity
RG45_RS05555	COG0306	phosphate transporter
RG45_RS05575	COG2076	Multidrug Resistance protein
RG45_RS05590	COG4869	propanediol catabolic process
RG45_RS05600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG45_RS05605	COG1882	Formate acetyltransferase
RG45_RS05610	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS05610	COG1454	alcohol dehydrogenase
RG45_RS05620	COG1454	alcohol dehydrogenase
RG45_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS05685	COG3039	Transposase
RG45_RS05695	COG0604	alcohol dehydrogenase
RG45_RS05740	COG0531	amino acid
RG45_RS05745	COG1982	Orn Lys Arg decarboxylase major
RG45_RS05750	COG0531	amino acid
RG45_RS05775	COG0582	viral genome integration into host DNA
RG45_RS05785	COG1811	Na channel or pump
RG45_RS05795	COG1982	Orn Lys Arg decarboxylase major
RG45_RS05800	COG2211	Major facilitator Superfamily
RG45_RS05815	COG1194	a g-specific adenine glycosylase
RG45_RS05830	COG3171	Protein conserved in bacteria
RG45_RS05840	COG0252	asparaginase activity
RG45_RS05850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG45_RS05865	COG0762	integral membrane protein
RG45_RS05870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RG45_RS05875	COG2805	Type II/IV secretion system protein
RG45_RS05890	COG0189	ligase activity
RG45_RS05895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RG45_RS05900	COG2356	endonuclease I
RG45_RS05910	COG2814	Major facilitator Superfamily
RG45_RS05940	COG1166	arginine decarboxylase activity
RG45_RS05950	COG0501	Belongs to the peptidase M48B family
RG45_RS05955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG45_RS05990	COG2213	PTS system mannitol-specific
RG45_RS05995	COG1063	alcohol dehydrogenase
RG45_RS06000	COG1494	fructose-1,6-bisphosphatase
RG45_RS06005	COG3722	fumarate hydratase activity
RG45_RS06010	COG1072	(Pantothenic acid kinase))
RG45_RS06030	COG0191	fructose-bisphosphate aldolase activity
RG45_RS06035	COG0668	transmembrane transport
RG45_RS06045	COG2968	Membrane
RG45_RS06050	COG0583	DNA-binding transcription factor activity
RG45_RS06055	COG0583	DNA-binding transcription factor activity
RG45_RS06060	COG0427	acetyl-CoA hydrolase
RG45_RS06065	COG1024	Enoyl-CoA hydratase
RG45_RS06070	COG1703	isobutyryl-CoA mutase activity
RG45_RS06075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG45_RS06075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG45_RS06100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RG45_RS06110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RG45_RS06135	COG0006	proline dipeptidase activity
RG45_RS06140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG45_RS06145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG45_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS06170	COG2723	6-phospho-beta-galactosidase activity
RG45_RS06180	COG1272	protein, Hemolysin III
RG45_RS06190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RG45_RS06200	COG0716	FMN binding
RG45_RS06205	COG4974	Belongs to the 'phage' integrase family
RG45_RS06210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG45_RS06215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RG45_RS06240	COG2233	PERMEase
RG45_RS06265	COG3829	transcription factor binding
RG45_RS06270	COG2080	2 iron, 2 sulfur cluster binding
RG45_RS06275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG45_RS06280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG45_RS06305	COG4942	peptidase
RG45_RS06360	COG0604	alcohol dehydrogenase
RG45_RS06365	COG2963	transposase activity
RG45_RS06370	COG3039	Transposase
RG45_RS06375	COG0814	amino acid
RG45_RS06380	COG0183	Belongs to the thiolase family
RG45_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS06395	COG2814	Major facilitator Superfamily
RG45_RS06400	COG1794	racemase activity, acting on amino acids and derivatives
RG45_RS06405	COG0583	DNA-binding transcription factor activity
RG45_RS06415	COG1609	Transcriptional regulator
RG45_RS06435	COG0667	Aldo Keto reductase
RG45_RS06445	COG0861	Integral membrane protein TerC family
RG45_RS06470	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
RG45_RS06485	COG2165	general secretion pathway protein
RG45_RS06490	COG4795	General secretion pathway protein
RG45_RS06500	COG4967	type IV pilus modification protein PilV
RG45_RS06505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RG45_RS06515	COG1074	ATP-dependent DNA helicase activity
RG45_RS06520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RG45_RS06525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RG45_RS06525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RG45_RS06530	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG45_RS06555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RG45_RS06560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RG45_RS06565	COG2166	iron-sulfur cluster assembly
RG45_RS06570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RG45_RS06580	COG0583	DNA-binding transcription factor activity
RG45_RS06585	COG2363	Small membrane protein
RG45_RS06595	COG1349	DNA-binding transcription factor activity
RG45_RS06605	COG1070	Carbohydrate kinase
RG45_RS06615	COG0738	Major facilitator superfamily
RG45_RS06620	COG0235	Class ii aldolase
RG45_RS06625	COG1454	alcohol dehydrogenase
RG45_RS06635	COG1760	l-serine dehydratase
RG45_RS06640	COG0814	amino acid
RG45_RS06645	COG1611	Belongs to the LOG family
RG45_RS06665	COG3098	single-species biofilm formation
RG45_RS06670	COG0564	pseudouridine synthase activity
RG45_RS06675	COG0716	FMN binding
RG45_RS06680	COG2271	Major facilitator Superfamily
RG45_RS06685	COG4948	Mandelate Racemase Muconate Lactonizing
RG45_RS06690	COG4948	Mandelate Racemase Muconate Lactonizing
RG45_RS06695	COG2205	protein histidine kinase activity
RG45_RS06695	COG4999	Histidine kinase
RG45_RS06695	COG3850	Histidine kinase
RG45_RS06695	COG3437	response regulator, receiver
RG45_RS06700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RG45_RS06705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG45_RS06710	COG2336	PFAM SpoVT AbrB
RG45_RS06715	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG45_RS06720	COG3956	TIGRFAM MazG family protein
RG45_RS06735	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG45_RS06745	COG0602	queuosine metabolic process
RG45_RS06755	COG2223	nitrite transmembrane transporter activity
RG45_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS06765	COG0277	FAD linked oxidase domain protein
RG45_RS06770	COG0477	Major facilitator Superfamily
RG45_RS06775	COG2086	electron transfer activity
RG45_RS06785	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RG45_RS06790	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG45_RS06795	COG0644	oxidoreductase
RG45_RS06800	COG0720	synthase
RG45_RS06810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG45_RS06820	COG2963	transposase activity
RG45_RS06825	COG2801	Transposase and inactivated derivatives
RG45_RS06840	COG3385	transposase activity
RG45_RS06845	COG1203	CRISPR-associated helicase, Cas3
RG45_RS06865	COG1857	crispr-associated protein
RG45_RS06880	COG1518	maintenance of DNA repeat elements
RG45_RS06885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG45_RS06890	COG2234	aminopeptidase activity
RG45_RS06945	COG4942	peptidase
RG45_RS06945	COG1388	LysM domain
RG45_RS06950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG45_RS06955	COG2610	gluconate transmembrane transporter activity
RG45_RS06960	COG3622	Belongs to the hyi family
RG45_RS06965	COG0235	Class ii aldolase
RG45_RS06970	COG3395	kinase activity
RG45_RS06975	COG2084	Dehydrogenase
RG45_RS06980	COG1349	DNA-binding transcription factor activity
RG45_RS06985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG45_RS07000	COG3604	Transcriptional regulator
RG45_RS07005	COG0309	Hydrogenase expression formation protein (HypE)
RG45_RS07010	COG0409	Hydrogenase expression formation protein
RG45_RS07015	COG0298	carbon dioxide binding
RG45_RS07020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RG45_RS07025	COG0375	protein maturation
RG45_RS07040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS07045	COG0651	ATP synthesis coupled electron transport
RG45_RS07050	COG0650	Formate hydrogenlyase subunit 4
RG45_RS07055	COG3261	NADH dehydrogenase
RG45_RS07055	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG45_RS07060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG45_RS07065	COG3260	NADH ubiquinone oxidoreductase 20
RG45_RS07075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG45_RS07080	COG2723	6-phospho-beta-galactosidase activity
RG45_RS07085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS07085	COG1263	PTS System
RG45_RS07090	COG1609	Transcriptional regulator
RG45_RS07095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS07100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RG45_RS07125	COG0517	IMP dehydrogenase activity
RG45_RS07125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG45_RS07130	COG1349	DNA-binding transcription factor activity
RG45_RS07135	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS07150	COG3732	PTS system glucitol sorbitol-specific
RG45_RS07155	COG3730	PTS system glucitol sorbitol-specific
RG45_RS07160	COG2951	lytic endotransglycosylase activity
RG45_RS07165	COG1546	Belongs to the CinA family
RG45_RS07190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RG45_RS07215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG45_RS07220	COG1238	metal cluster binding
RG45_RS07235	COG2814	Major facilitator Superfamily
RG45_RS07240	COG1566	PFAM secretion protein HlyD family protein
RG45_RS07245	COG1846	Transcriptional regulator
RG45_RS07255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RG45_RS07260	COG2814	Major facilitator Superfamily
RG45_RS07265	COG2113	Glycine betaine
RG45_RS07270	COG4176	ABC-type proline glycine betaine transport system permease component
RG45_RS07275	COG4175	Glycine betaine
RG45_RS07280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG45_RS07285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG45_RS07295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG45_RS07300	COG4575	ribosome binding
RG45_RS07315	COG2916	Histone family protein nucleoid-structuring protein H-NS
RG45_RS07320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG45_RS07325	COG0640	Transcriptional regulator
RG45_RS07330	COG0401	homolog of Blt101
RG45_RS07335	COG1652	LysM domain
RG45_RS07340	COG1802	Transcriptional regulator
RG45_RS07345	COG1113	amino acid transport
RG45_RS07350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG45_RS07355	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS07360	COG0579	oxidoreductase
RG45_RS07375	COG0366	Alpha amylase catalytic
RG45_RS07380	COG0366	Alpha amylase catalytic
RG45_RS07415	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS07425	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS07440	COG2867	negative regulation of translational initiation
RG45_RS07450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG45_RS07455	COG0497	DNA recombination
RG45_RS07475	COG4536	flavin adenine dinucleotide binding
RG45_RS07480	COG4137	Cytochrome C assembly protein
RG45_RS07485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RG45_RS07510	COG2885	chlorophyll binding
RG45_RS07515	COG2199	diguanylate cyclase activity
RG45_RS07530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG45_RS07535	COG1605	Chorismate mutase
RG45_RS07535	COG0287	Prephenate dehydrogenase
RG45_RS07540	COG0077	Prephenate dehydratase
RG45_RS07540	COG1605	Chorismate mutase
RG45_RS07545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG45_RS07555	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG45_RS07560	COG0564	pseudouridine synthase activity
RG45_RS07570	COG0542	response to heat
RG45_RS07605	COG0477	Major facilitator Superfamily
RG45_RS07610	COG5544	Lipoprotein
RG45_RS07615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG45_RS07620	COG1042	CoA-binding domain protein
RG45_RS07620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG45_RS07620	COG0045	succinate-CoA ligase (ADP-forming) activity
RG45_RS07625	COG3148	PFAM DTW domain containing protein
RG45_RS07630	COG3118	belongs to the thioredoxin family
RG45_RS07635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG45_RS07655	COG0583	DNA-binding transcription factor activity
RG45_RS07660	COG0513	Belongs to the DEAD box helicase family
RG45_RS07670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG45_RS07680	COG1595	DNA-templated transcription, initiation
RG45_RS07685	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RG45_RS07690	COG3026	antisigma factor binding
RG45_RS07695	COG3086	response to oxidative stress
RG45_RS07705	COG0681	Belongs to the peptidase S26 family
RG45_RS07730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RG45_RS07755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS07760	COG1737	Transcriptional regulator
RG45_RS07765	COG0560	Phosphoserine phosphatase
RG45_RS07785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RG45_RS07785	COG0047	phosphoribosylformylglycinamidine synthase activity
RG45_RS07790	COG2205	protein histidine kinase activity
RG45_RS07795	COG3170	Tfp pilus assembly protein FimV
RG45_RS07800	COG2204	response regulator
RG45_RS07805	COG0347	Belongs to the P(II) protein family
RG45_RS07810	COG1017	nitric oxide dioxygenase activity
RG45_RS07810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG45_RS07825	COG1940	carbohydrate kinase activity
RG45_RS07830	COG0457	Tetratricopeptide repeat
RG45_RS07835	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS07840	COG1129	ABC transporter
RG45_RS07845	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG45_RS07850	COG1063	alcohol dehydrogenase
RG45_RS07855	COG2017	converts alpha-aldose to the beta-anomer
RG45_RS07860	COG2259	Doxx family
RG45_RS07885	COG4638	Rieske (2fe-2S)
RG45_RS07890	COG0583	DNA-binding transcription factor activity
RG45_RS07895	COG2814	Major facilitator Superfamily
RG45_RS07900	COG3711	transcriptional antiterminator
RG45_RS07905	COG1073	alpha beta
RG45_RS07910	COG0483	inositol monophosphate 1-phosphatase activity
RG45_RS07930	COG0822	iron-sulfur transferase activity
RG45_RS07950	COG0633	Ferredoxin
RG45_RS07955	COG2975	iron-sulfur cluster assembly
RG45_RS07970	COG2897	thiosulfate sulfurtransferase activity
RG45_RS07975	COG2373	Large extracellular alpha-helical protein
RG45_RS07980	COG4953	penicillin-binding protein 1C
RG45_RS08010	COG2976	Protein conserved in bacteria
RG45_RS08025	COG1645	bacterial-type flagellum-dependent swarming motility
RG45_RS08035	COG0517	IMP dehydrogenase activity
RG45_RS08035	COG0516	GMP reductase activity
RG45_RS08060	COG3133	Outer membrane lipoprotein
RG45_RS08080	COG2200	EAL domain
RG45_RS08085	COG0248	Ppx GppA phosphatase
RG45_RS08090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RG45_RS08095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RG45_RS08115	COG2233	PERMEase
RG45_RS08125	COG1393	Belongs to the ArsC family
RG45_RS08130	COG4783	chaperone-mediated protein folding
RG45_RS08135	COG0628	permease
RG45_RS08140	COG2116	formate transmembrane transporter activity
RG45_RS08145	COG3604	Transcriptional regulator
RG45_RS08155	COG3260	NADH ubiquinone oxidoreductase 20
RG45_RS08160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG45_RS08165	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG45_RS08165	COG3261	NADH dehydrogenase
RG45_RS08170	COG0651	ATP synthesis coupled electron transport
RG45_RS08175	COG4237	Hydrogenase 4 membrane
RG45_RS08180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG45_RS08185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG45_RS08190	COG0650	Formate hydrogenlyase subunit 4
RG45_RS08195	COG0651	ATP synthesis coupled electron transport
RG45_RS08200	COG0651	ATP synthesis coupled electron transport
RG45_RS08205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS08210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RG45_RS08215	COG2716	regulation of RNA biosynthetic process
RG45_RS08225	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RG45_RS08240	COG2321	neutral zinc metallopeptidase
RG45_RS08250	COG0400	carboxylic ester hydrolase activity
RG45_RS08265	COG1393	Belongs to the ArsC family
RG45_RS08275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG45_RS08280	COG3850	Histidine kinase
RG45_RS08285	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS08285	COG0493	'glutamate synthase
RG45_RS08295	COG5342	invasion associated locus B
RG45_RS08300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG45_RS08305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG45_RS08310	COG0281	malic enzyme
RG45_RS08310	COG0280	phosphate acetyltransferase
RG45_RS08315	COG4810	utilization protein
RG45_RS08320	COG4917	ethanolamine utilization protein
RG45_RS08325	COG4766	ethanolamine catabolic process
RG45_RS08330	COG4812	Cobalamin adenosyltransferase
RG45_RS08335	COG0280	phosphate acetyltransferase
RG45_RS08340	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG45_RS08345	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RG45_RS08350	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS08355	COG4820	ethanolamine utilization protein (EutJ)
RG45_RS08360	COG1454	alcohol dehydrogenase
RG45_RS08365	COG3192	ethanolamine utilization protein
RG45_RS08370	COG4819	ethanolamine utilization protein
RG45_RS08390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RG45_RS08395	COG0531	amino acid
RG45_RS08400	COG0076	glutamate decarboxylase activity
RG45_RS08405	COG0076	glutamate decarboxylase activity
RG45_RS08440	COG2207	Transcriptional regulator
RG45_RS08450	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG45_RS08470	COG2837	iron assimilation
RG45_RS08475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG45_RS08480	COG1263	PTS System
RG45_RS08480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS08500	COG4150	thiosulfate binding
RG45_RS08505	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RG45_RS08510	COG4208	sulfate ABC transporter
RG45_RS08515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RG45_RS08520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG45_RS08525	COG4884	unkown
RG45_RS08525	COG3831	ATPase activity
RG45_RS08540	COG2190	(PTS) system
RG45_RS08545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG45_RS08550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS08555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG45_RS08580	COG3530	Putative quorum-sensing-regulated virulence factor
RG45_RS08585	COG0385	Bile acid
RG45_RS08590	COG0583	DNA-binding transcription factor activity
RG45_RS08630	COG3415	Transposase
RG45_RS08640	COG3415	Transposase
RG45_RS08645	COG3415	Transposase
RG45_RS08660	COG2200	EAL domain
RG45_RS08660	COG2199	diguanylate cyclase activity
RG45_RS08665	COG3385	transposase activity
RG45_RS08675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG45_RS08705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS08710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS08715	COG0006	proline dipeptidase activity
RG45_RS08720	COG1363	Peptidase, m42
RG45_RS08730	COG2207	Transcriptional regulator
RG45_RS08735	COG3279	Response regulator of the LytR AlgR family
RG45_RS08740	COG3275	phosphorelay sensor kinase activity
RG45_RS08745	COG0436	Aminotransferase
RG45_RS08755	COG1560	Kdo2-lipid A biosynthetic process
RG45_RS08785	COG0028	Belongs to the TPP enzyme family
RG45_RS08790	COG0679	Auxin Efflux Carrier
RG45_RS08795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RG45_RS08800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS08800	COG2205	protein histidine kinase activity
RG45_RS08800	COG0784	Response regulator, receiver
RG45_RS08800	COG2198	Histidine kinase
RG45_RS08805	COG2197	response regulator
RG45_RS08810	COG1566	PFAM secretion protein HlyD family protein
RG45_RS08815	COG0477	Major facilitator Superfamily
RG45_RS08825	COG2610	gluconate transmembrane transporter activity
RG45_RS08860	COG2116	formate transmembrane transporter activity
RG45_RS08865	COG2853	Lipoprotein
RG45_RS08880	COG2067	long-chain fatty acid transport protein
RG45_RS08890	COG3691	Protein conserved in bacteria
RG45_RS08905	COG2062	phosphohistidine phosphatase, SixA
RG45_RS08910	COG3539	Fimbrial protein
RG45_RS08915	COG3188	usher protein
RG45_RS08920	COG3121	Chaperone
RG45_RS08925	COG3539	Fimbrial protein
RG45_RS08930	COG3539	Fimbrial protein
RG45_RS08935	COG3539	Fimbrial protein
RG45_RS08965	COG0730	response to heat
RG45_RS08970	COG3101	peptidyl-lysine hydroxylation
RG45_RS08985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG45_RS08995	COG2814	Major facilitator Superfamily
RG45_RS09010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG45_RS09020	COG0586	Pfam SNARE associated Golgi protein
RG45_RS09030	COG0285	dihydrofolate synthase activity
RG45_RS09035	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RG45_RS09045	COG1286	toxin biosynthetic process
RG45_RS09050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RG45_RS09055	COG0163	prenyltransferase activity
RG45_RS09060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS09065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS09070	COG4215	(ABC) transporter
RG45_RS09075	COG4160	amino acid transport
RG45_RS09080	COG4598	ABC transporter
RG45_RS09085	COG5464	transposase or invertase
RG45_RS09090	COG1090	epimerase
RG45_RS09095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG45_RS09100	COG0625	glutathione transferase activity
RG45_RS09105	COG0625	glutathione transferase activity
RG45_RS09110	COG0622	Phosphoesterase
RG45_RS09115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RG45_RS09120	COG1288	antiporter activity
RG45_RS09125	COG0857	belongs to the CobB CobQ family
RG45_RS09125	COG0280	phosphate acetyltransferase
RG45_RS09130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG45_RS09150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG45_RS09155	COG0490	domain, Protein
RG45_RS09155	COG0471	metal ion transport
RG45_RS09165	COG0436	Aminotransferase
RG45_RS09175	COG0583	DNA-binding transcription factor activity
RG45_RS09195	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RG45_RS09200	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RG45_RS09205	COG1034	ATP synthesis coupled electron transport
RG45_RS09220	COG0839	Belongs to the complex I subunit 6 family
RG45_RS09230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG45_RS09235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG45_RS09265	COG2153	protein acetylation
RG45_RS09270	COG4575	ribosome binding
RG45_RS09275	COG1169	isochorismate synthase
RG45_RS09290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RG45_RS09300	COG0318	PFAM AMP-dependent synthetase and ligase
RG45_RS09370	COG5464	transposase or invertase
RG45_RS09375	COG0247	lactate metabolic process
RG45_RS09385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG45_RS09395	COG2271	Major facilitator Superfamily
RG45_RS09400	COG0584	glycerophosphoryl diester phosphodiesterase
RG45_RS09405	COG0583	DNA-binding transcription factor activity
RG45_RS09415	COG3642	lipopolysaccharide core region biosynthetic process
RG45_RS09420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG45_RS09425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG45_RS09430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG45_RS09440	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS09450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG45_RS09455	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RG45_RS09460	COG3234	Protein of unknown function (DUF1175)
RG45_RS09465	COG2373	Large extracellular alpha-helical protein
RG45_RS09470	COG5445	Predicted secreted protein (DUF2300)
RG45_RS09475	COG4676	Protein conserved in bacteria
RG45_RS09480	COG2205	protein histidine kinase activity
RG45_RS09480	COG0784	Response regulator, receiver
RG45_RS09490	COG2197	response regulator
RG45_RS09495	COG2198	Histidine kinase
RG45_RS09495	COG0642	Histidine kinase
RG45_RS09510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG45_RS09515	COG1477	protein flavinylation
RG45_RS09520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG45_RS09520	COG2169	Transcriptional regulator
RG45_RS09525	COG3145	DNA-N1-methyladenine dioxygenase activity
RG45_RS09530	COG4615	Cyclic peptide transporter
RG45_RS09550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS09550	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG45_RS09555	COG3062	negative regulation of establishment of protein localization
RG45_RS09565	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS09570	COG0348	domain, Protein
RG45_RS09575	COG3043	anaerobic respiration
RG45_RS09580	COG3005	denitrification pathway
RG45_RS09590	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG45_RS09595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG45_RS09600	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG45_RS09610	COG1138	Cytochrome C-type biogenesis protein
RG45_RS09615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RG45_RS09620	COG3088	subunit of a heme lyase
RG45_RS09620	COG4235	cytochrome complex assembly
RG45_RS09625	COG2197	response regulator
RG45_RS09635	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS09650	COG3083	sulfuric ester hydrolase activity
RG45_RS09670	COG1061	Type III restriction enzyme res subunit
RG45_RS09680	COG1187	pseudouridine synthase activity
RG45_RS09685	COG2814	Major facilitator Superfamily
RG45_RS09700	COG4172	Belongs to the ABC transporter superfamily
RG45_RS09705	COG4239	(ABC) transporter, permease
RG45_RS09710	COG4174	ABC transporter (Permease)
RG45_RS09715	COG4166	transmembrane transport
RG45_RS09725	COG2200	EAL domain
RG45_RS09730	COG2200	EAL domain
RG45_RS09735	COG0791	NLP P60 protein
RG45_RS09740	COG0671	phosphoesterase, PA-phosphatase related
RG45_RS09745	COG0523	cobalamin synthesis protein
RG45_RS09750	COG0246	Mannitol dehydrogenase
RG45_RS09765	COG2814	Major facilitator Superfamily
RG45_RS09770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS09770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS09775	COG1105	Belongs to the carbohydrate kinase PfkB family
RG45_RS09780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS09780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS09780	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RG45_RS09785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS09790	COG2313	pseudouridylate synthase activity
RG45_RS09795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG45_RS09800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG45_RS09810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG45_RS09815	COG1522	sequence-specific DNA binding
RG45_RS09815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS09825	COG2855	membrane
RG45_RS09830	COG0583	DNA-binding transcription factor activity
RG45_RS09840	COG0833	amino acid
RG45_RS09845	COG4771	TonB-dependent receptor
RG45_RS09865	COG2311	Membrane
RG45_RS09875	COG1609	Transcriptional regulator
RG45_RS09880	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS09885	COG1129	ABC transporter
RG45_RS09890	COG4211	Belongs to the binding-protein-dependent transport system permease family
RG45_RS09895	COG0167	dihydroorotate dehydrogenase activity
RG45_RS09895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RG45_RS09900	COG0493	'glutamate synthase
RG45_RS09910	COG2949	membrane
RG45_RS09920	COG1346	cytolysis
RG45_RS09930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG45_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS09955	COG0586	Pfam SNARE associated Golgi protein
RG45_RS09965	COG1686	Belongs to the peptidase S11 family
RG45_RS09970	COG0277	FAD linked oxidase domain protein
RG45_RS09975	COG1472	Belongs to the glycosyl hydrolase 3 family
RG45_RS09980	COG1732	Glycine betaine
RG45_RS09985	COG1174	glycine betaine transport
RG45_RS09990	COG1125	glycine betaine transport
RG45_RS09995	COG1174	glycine betaine transport
RG45_RS10005	COG0789	Transcriptional regulator
RG45_RS10010	COG3275	phosphorelay sensor kinase activity
RG45_RS10015	COG3279	Response regulator of the LytR AlgR family
RG45_RS10020	COG4807	Protein conserved in bacteria
RG45_RS10025	COG4808	Protein conserved in bacteria
RG45_RS10030	COG4715	Zinc finger, swim domain protein
RG45_RS10035	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RG45_RS10040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RG45_RS10045	COG0714	Associated with various cellular activities
RG45_RS10070	COG0489	protein tyrosine kinase activity
RG45_RS10085	COG3539	Fimbrial protein
RG45_RS10090	COG3121	Chaperone
RG45_RS10095	COG3188	usher protein
RG45_RS10100	COG3539	Fimbrial protein
RG45_RS10105	COG5455	response to cobalt ion
RG45_RS10110	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RG45_RS10125	COG0351	phosphomethylpyrimidine kinase
RG45_RS10130	COG3757	hydrolase, family 25
RG45_RS10135	COG2188	Transcriptional regulator
RG45_RS10140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS10145	COG1397	ADP-ribosylglycohydrolase
RG45_RS10150	COG2211	Major facilitator Superfamily
RG45_RS10155	COG1830	Aldolase
RG45_RS10170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS10175	COG3414	Phosphotransferase system galactitol-specific IIB component
RG45_RS10180	COG3775	system Galactitol-specific IIC component
RG45_RS10185	COG1063	alcohol dehydrogenase
RG45_RS10210	COG0826	peptidase U32
RG45_RS10225	COG0745	RESPONSE REGULATOR receiver
RG45_RS10230	COG2205	protein histidine kinase activity
RG45_RS10265	COG4245	von Willebrand factor, type A
RG45_RS10270	COG0631	protein serine/threonine phosphatase activity
RG45_RS10295	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
RG45_RS10300	COG0443	Heat shock 70 kDa protein
RG45_RS10310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RG45_RS10320	COG0572	uridine kinase
RG45_RS10330	COG2982	Protein involved in outer membrane biogenesis
RG45_RS10340	COG1253	flavin adenine dinucleotide binding
RG45_RS10490	COG0140	phosphoribosyl-ATP diphosphatase activity
RG45_RS10490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RG45_RS10505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RG45_RS10510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG45_RS10510	COG0131	Imidazoleglycerol-phosphate dehydratase
RG45_RS10540	COG2161	toxin-antitoxin pair type II binding
RG45_RS10545	COG4115	mRNA cleavage
RG45_RS10550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG45_RS10555	COG0583	DNA-binding transcription factor activity
RG45_RS10560	COG0531	amino acid
RG45_RS10565	COG2391	methyltransferase activity
RG45_RS10570	COG0425	Belongs to the sulfur carrier protein TusA family
RG45_RS10575	COG2925	Exonuclease
RG45_RS10580	COG1686	Belongs to the peptidase S11 family
RG45_RS10590	COG1289	transmembrane transporter activity
RG45_RS10600	COG4917	ethanolamine utilization protein
RG45_RS10705	COG0405	Gamma-glutamyltransferase
RG45_RS10710	COG4372	Transposase
RG45_RS10715	COG3436	PFAM IS66 Orf2 family protein
RG45_RS10725	COG0405	Gamma-glutamyltransferase
RG45_RS10755	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RG45_RS10770	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RG45_RS10785	COG1376	ErfK ybiS ycfS ynhG family protein
RG45_RS10795	COG0583	DNA-binding transcription factor activity
RG45_RS10800	COG0583	DNA-binding transcription factor activity
RG45_RS10810	COG0534	Mate efflux family protein
RG45_RS10825	COG0217	transcriptional regulatory protein
RG45_RS10830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RG45_RS10835	COG0477	Major facilitator Superfamily
RG45_RS10845	COG1470	cell adhesion involved in biofilm formation
RG45_RS10845	COG1388	LysM domain
RG45_RS10850	COG1388	LysM domain
RG45_RS10850	COG2373	Large extracellular alpha-helical protein
RG45_RS10850	COG4932	domain protein
RG45_RS10875	COG3038	cytochrome b561
RG45_RS10880	COG3443	Belongs to the bacterial solute-binding protein 9 family
RG45_RS10895	COG2351	hydroxyisourate hydrolase activity
RG45_RS10900	COG0745	RESPONSE REGULATOR receiver
RG45_RS10905	COG2205	protein histidine kinase activity
RG45_RS10920	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG45_RS10935	COG1418	mRNA catabolic process
RG45_RS10940	COG0270	DNA (cytosine-5-)-methyltransferase activity
RG45_RS10945	COG3727	T/G mismatch-specific endonuclease activity
RG45_RS10950	COG0697	spore germination
RG45_RS10955	COG2354	Protein conserved in bacteria
RG45_RS10960	COG5475	Uncharacterized small protein (DUF2158)
RG45_RS10995	COG2197	response regulator
RG45_RS11000	COG1684	flagellar biosynthetic protein fliR
RG45_RS11005	COG1987	bacterial-type flagellum assembly
RG45_RS11010	COG1338	Plays a role in the flagellum-specific transport system
RG45_RS11015	COG3190	flagellar
RG45_RS11020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG45_RS11025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG45_RS11030	COG1580	Controls the rotational direction of flagella during chemotaxis
RG45_RS11035	COG3144	bacterial-type flagellum assembly
RG45_RS11040	COG2882	bacterial-type flagellum organization
RG45_RS11045	COG1157	protein secretion by the type III secretion system
RG45_RS11050	COG1317	bacterial-type flagellum organization
RG45_RS11055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG45_RS11060	COG1766	The M ring may be actively involved in energy transduction
RG45_RS11075	COG2076	Multidrug Resistance protein
RG45_RS11080	COG1881	PFAM PEBP family protein
RG45_RS11085	COG2207	Transcriptional regulator
RG45_RS11115	COG0675	Transposase, IS605 OrfB family
RG45_RS11120	COG2135	peptidase activity
RG45_RS11125	COG0425	Belongs to the sulfur carrier protein TusA family
RG45_RS11130	COG2391	methyltransferase activity
RG45_RS11145	COG0366	Alpha amylase catalytic
RG45_RS11155	COG1516	flagellar protein fliS
RG45_RS11160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RG45_RS11165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG45_RS11170	COG1191	sigma factor activity
RG45_RS11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS11190	COG0765	amino acid transport
RG45_RS11195	COG1126	abc transporter atp-binding protein
RG45_RS11200	COG2197	response regulator
RG45_RS11240	COG2197	response regulator
RG45_RS11270	COG3318	Belongs to the UPF0149 family
RG45_RS11270	COG3012	SEC-C Motif Domain Protein
RG45_RS11275	COG0814	amino acid
RG45_RS11285	COG1528	Iron-storage protein
RG45_RS11305	COG1528	Iron-storage protein
RG45_RS11315	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS11320	COG1129	ABC transporter
RG45_RS11325	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG45_RS11330	COG1877	trehalose-phosphatase activity
RG45_RS11340	COG0589	response to stress
RG45_RS11355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RG45_RS11360	COG1360	Flagellar Motor Protein
RG45_RS11365	COG0643	Histidine kinase
RG45_RS11365	COG2198	Histidine kinase
RG45_RS11370	COG0835	chemotaxis
RG45_RS11375	COG0840	transmembrane signaling receptor activity
RG45_RS11380	COG0840	transmembrane signaling receptor activity
RG45_RS11385	COG0840	transmembrane signaling receptor activity
RG45_RS11390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RG45_RS11400	COG0745	RESPONSE REGULATOR receiver
RG45_RS11405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RG45_RS11410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG45_RS11425	COG3755	Protein conserved in bacteria
RG45_RS11460	COG3102	Protein conserved in bacteria
RG45_RS11470	COG3005	denitrification pathway
RG45_RS11475	COG0243	molybdopterin cofactor binding
RG45_RS11490	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RG45_RS11495	COG1801	Protein of unknown function DUF72
RG45_RS11555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG45_RS11560	COG1801	Protein of unknown function DUF72
RG45_RS11565	COG1335	isochorismatase
RG45_RS11575	COG0494	nUDIX hydrolase
RG45_RS11580	COG0217	transcriptional regulatory protein
RG45_RS11610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG45_RS11620	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RG45_RS11625	COG0739	heme binding
RG45_RS11630	COG1560	Kdo2-lipid A biosynthetic process
RG45_RS11635	COG0469	pyruvate kinase activity
RG45_RS11640	COG1737	Transcriptional regulator
RG45_RS11655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RG45_RS11660	COG0129	dihydroxy-acid dehydratase activity
RG45_RS11665	COG0800	Aldolase
RG45_RS11675	COG3141	response to X-ray
RG45_RS11715	COG2979	Protein of unknown function (DUF533)
RG45_RS11725	COG1770	oligopeptidase
RG45_RS11730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG45_RS11735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG45_RS11745	COG2372	response to copper ion
RG45_RS11750	COG1276	copper resistance
RG45_RS11765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG45_RS11785	COG3008	intermembrane lipid transfer
RG45_RS11790	COG2995	paraquat-inducible protein a
RG45_RS11795	COG1956	GAF domain-containing protein
RG45_RS11805	COG0793	Belongs to the peptidase S41A family
RG45_RS11815	COG2814	Major facilitator Superfamily
RG45_RS11820	COG1414	Transcriptional regulator
RG45_RS11855	COG2226	methyltransferase
RG45_RS11870	COG3716	PTS system mannose fructose sorbose family IID component
RG45_RS11875	COG3715	PTS system
RG45_RS11880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS11880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS11895	COG1253	flavin adenine dinucleotide binding
RG45_RS11900	COG2200	EAL domain
RG45_RS11905	COG1760	l-serine dehydratase
RG45_RS11915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG45_RS11935	COG0251	oxidation-reduction process
RG45_RS11940	COG1199	ATP-dependent helicase activity
RG45_RS11945	COG1214	PFAM Peptidase M22, glycoprotease
RG45_RS11950	COG3065	identical protein binding
RG45_RS11955	COG0318	PFAM AMP-dependent synthetase and ligase
RG45_RS11960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RG45_RS11965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG45_RS11970	COG4638	Rieske (2fe-2S)
RG45_RS11975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG45_RS11980	COG0473	3-isopropylmalate dehydrogenase activity
RG45_RS11985	COG0583	DNA-binding transcription factor activity
RG45_RS11995	COG3615	Tellurite resistance protein tehB
RG45_RS12005	COG2261	transglycosylase associated protein
RG45_RS12020	COG2203	Gaf domain
RG45_RS12020	COG2199	diguanylate cyclase activity
RG45_RS12025	COG3042	response to heat
RG45_RS12030	COG3189	MarR family transcriptional regulator
RG45_RS12040	COG2207	Transcriptional regulator
RG45_RS12055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG45_RS12060	COG2199	diguanylate cyclase activity
RG45_RS12065	COG2199	diguanylate cyclase activity
RG45_RS12075	COG2766	serine protein kinase
RG45_RS12080	COG3713	MltA-interacting MipA family protein
RG45_RS12085	COG0656	L-ascorbic acid biosynthetic process
RG45_RS12090	COG0676	glucose-6-phosphate 1-epimerase activity
RG45_RS12095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG45_RS12105	COG3139	Protein of unknown function (DUF1315)
RG45_RS12110	COG1063	alcohol dehydrogenase
RG45_RS12115	COG2271	Major facilitator Superfamily
RG45_RS12120	COG1063	alcohol dehydrogenase
RG45_RS12145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS12150	COG0667	Aldo Keto reductase
RG45_RS12155	COG1349	DNA-binding transcription factor activity
RG45_RS12160	COG2814	Major facilitator Superfamily
RG45_RS12165	COG1335	isochorismatase
RG45_RS12170	COG0252	asparaginase activity
RG45_RS12175	COG0616	signal peptide processing
RG45_RS12180	COG0778	Nitroreductase
RG45_RS12195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG45_RS12205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RG45_RS12215	COG0494	nUDIX hydrolase
RG45_RS12220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG45_RS12225	COG2897	thiosulfate sulfurtransferase activity
RG45_RS12230	COG4136	ATPase activity
RG45_RS12235	COG4135	transport system, permease component
RG45_RS12240	COG4134	Bacterial extracellular solute-binding protein
RG45_RS12245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG45_RS12250	COG0398	Pfam SNARE associated Golgi protein
RG45_RS12260	COG0398	Pfam SNARE associated Golgi protein
RG45_RS12265	COG0708	Exodeoxyribonuclease III
RG45_RS12300	COG3678	ATP-independent chaperone mediated protein folding
RG45_RS12310	COG0322	excinuclease ABC activity
RG45_RS12320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG45_RS12330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG45_RS12335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG45_RS12340	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG45_RS12345	COG2169	Transcriptional regulator
RG45_RS12345	COG1917	Cupin 2, conserved barrel domain protein
RG45_RS12350	COG1486	melibiose metabolic process
RG45_RS12365	COG0753	catalase activity
RG45_RS12380	COG1823	symporter activity
RG45_RS12385	COG1988	membrane-bound metal-dependent
RG45_RS12390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG45_RS12400	COG3001	Fructosamine kinase
RG45_RS12410	COG1105	Belongs to the carbohydrate kinase PfkB family
RG45_RS12415	COG3137	Salt-induced outer membrane protein
RG45_RS12495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG45_RS12495	COG0072	phenylalanine-tRNA ligase activity
RG45_RS12510	COG0386	Belongs to the glutathione peroxidase family
RG45_RS12520	COG0791	NLP P60 protein
RG45_RS12535	COG4256	Hemin uptake protein
RG45_RS12540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG45_RS12550	COG0574	Belongs to the PEP-utilizing enzyme family
RG45_RS12550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG45_RS12555	COG0318	PFAM AMP-dependent synthetase and ligase
RG45_RS12560	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG45_RS12565	COG0644	oxidoreductase
RG45_RS12570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG45_RS12575	COG2086	electron transfer activity
RG45_RS12585	COG2207	Transcriptional regulator
RG45_RS12585	COG1917	Cupin 2, conserved barrel domain protein
RG45_RS12590	COG1960	acyl-CoA dehydrogenase activity
RG45_RS12595	COG4670	ketone body catabolic process
RG45_RS12610	COG2271	Major facilitator Superfamily
RG45_RS12615	COG0738	Major facilitator superfamily
RG45_RS12630	COG0628	permease
RG45_RS12640	COG0247	lactate metabolic process
RG45_RS12640	COG0277	FAD linked oxidase domain protein
RG45_RS12645	COG2050	protein possibly involved in aromatic compounds catabolism
RG45_RS12655	COG0316	Belongs to the HesB IscA family
RG45_RS12660	COG0719	Fe-S assembly protein
RG45_RS12665	COG0396	ATPase activity
RG45_RS12670	COG0719	Fe-S assembly protein
RG45_RS12685	COG1376	ErfK ybiS ycfS ynhG family protein
RG45_RS12690	COG4238	major outer membrane lipoprotein
RG45_RS12695	COG0469	pyruvate kinase activity
RG45_RS12705	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS12710	COG2414	aldehyde ferredoxin oxidoreductase
RG45_RS12720	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS12725	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RG45_RS12735	COG4529	Protein conserved in bacteria
RG45_RS12755	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS12765	COG0307	riboflavin synthase, alpha
RG45_RS12770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RG45_RS12775	COG2814	Major facilitator Superfamily
RG45_RS12780	COG0583	DNA-binding transcription factor activity
RG45_RS12800	COG2814	Major facilitator Superfamily
RG45_RS12805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG45_RS12810	COG0791	NLP P60 protein
RG45_RS12815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RG45_RS12820	COG1201	RNA secondary structure unwinding
RG45_RS12830	COG0346	lactoylglutathione lyase activity
RG45_RS12835	COG1902	pentaerythritol trinitrate reductase activity
RG45_RS12840	COG1309	transcriptional regulator
RG45_RS12845	COG3313	Fe-S protein
RG45_RS12850	COG4989	oxidoreductase activity
RG45_RS12855	COG2032	superoxide dismutase activity
RG45_RS12860	COG1289	transmembrane transporter activity
RG45_RS12865	COG1566	PFAM secretion protein HlyD family protein
RG45_RS12880	COG3133	Outer membrane lipoprotein
RG45_RS12890	COG3895	Periplasmic Protein
RG45_RS12905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RG45_RS12910	COG0625	glutathione transferase activity
RG45_RS12915	COG3104	oligopeptide transport
RG45_RS12925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RG45_RS12935	COG4659	FMN binding
RG45_RS12980	COG0673	inositol 2-dehydrogenase activity
RG45_RS12990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RG45_RS13000	COG1609	Transcriptional regulator
RG45_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS13010	COG1309	transcriptional regulator
RG45_RS13015	COG3250	beta-galactosidase activity
RG45_RS13030	COG5339	Protein conserved in bacteria
RG45_RS13035	COG1482	cell wall glycoprotein biosynthetic process
RG45_RS13040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG45_RS13040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG45_RS13045	COG0114	fumarate hydratase activity
RG45_RS13055	COG2205	protein histidine kinase activity
RG45_RS13060	COG0745	RESPONSE REGULATOR receiver
RG45_RS13065	COG3136	membrane protein required for alginate biosynthesis
RG45_RS13075	COG0531	amino acid
RG45_RS13090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RG45_RS13095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RG45_RS13100	COG0628	permease
RG45_RS13115	COG3591	Belongs to the peptidase S1B family
RG45_RS13135	COG2814	Major facilitator Superfamily
RG45_RS13140	COG0583	DNA-binding transcription factor activity
RG45_RS13145	COG1940	carbohydrate kinase activity
RG45_RS13150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG45_RS13160	COG3381	protein complex oligomerization
RG45_RS13165	COG3302	dmso reductase anchor subunit
RG45_RS13170	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS13175	COG0243	molybdopterin cofactor binding
RG45_RS13180	COG0243	molybdopterin cofactor binding
RG45_RS13195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG45_RS13215	COG4948	Mandelate Racemase Muconate Lactonizing
RG45_RS13220	COG1063	alcohol dehydrogenase
RG45_RS13230	COG0582	viral genome integration into host DNA
RG45_RS13240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG45_RS13275	COG1846	Transcriptional regulator
RG45_RS13280	COG4771	TonB-dependent receptor
RG45_RS13305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG45_RS13310	COG1403	HNH endonuclease
RG45_RS13325	COG3272	Protein of unknown function (DUF1722)
RG45_RS13355	COG2207	Transcriptional regulator
RG45_RS13375	COG3772	lysozyme
RG45_RS13385	COG1278	Cold shock
RG45_RS13395	COG2801	Transposase and inactivated derivatives
RG45_RS13450	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG45_RS13480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG45_RS13485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG45_RS13495	COG0477	Major facilitator Superfamily
RG45_RS13500	COG0246	Mannitol dehydrogenase
RG45_RS13505	COG0246	Mannitol dehydrogenase
RG45_RS13515	COG1802	Transcriptional regulator
RG45_RS13520	COG4221	oxidoreductase activity
RG45_RS13530	COG0339	signal peptide processing
RG45_RS13540	COG1546	Belongs to the CinA family
RG45_RS13545	COG3111	PFAM Bacterial OB fold (BOF) protein
RG45_RS13550	COG3706	GGDEF domain
RG45_RS13560	COG2814	Major facilitator Superfamily
RG45_RS13565	COG0697	spore germination
RG45_RS13590	COG2188	Transcriptional regulator
RG45_RS13600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG45_RS13605	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG45_RS13620	COG2723	6-phospho-beta-galactosidase activity
RG45_RS13630	COG4977	sequence-specific DNA binding
RG45_RS13635	COG1846	Transcriptional regulator
RG45_RS13655	COG2801	Transposase and inactivated derivatives
RG45_RS13670	COG0583	DNA-binding transcription factor activity
RG45_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS13680	COG2066	Belongs to the glutaminase family
RG45_RS13690	COG2199	diguanylate cyclase activity
RG45_RS13710	COG3781	membrane
RG45_RS13760	COG2911	Protein conserved in bacteria
RG45_RS13760	COG3210	domain, Protein
RG45_RS13785	COG2911	Protein conserved in bacteria
RG45_RS13785	COG3210	domain, Protein
RG45_RS13790	COG1396	sequence-specific DNA binding
RG45_RS13795	COG3550	peptidyl-serine autophosphorylation
RG45_RS13805	COG4977	sequence-specific DNA binding
RG45_RS13810	COG3188	usher protein
RG45_RS13815	COG3539	Fimbrial protein
RG45_RS13820	COG3539	Fimbrial protein
RG45_RS13825	COG3539	Fimbrial protein
RG45_RS13830	COG0243	molybdopterin cofactor binding
RG45_RS13840	COG2207	Transcriptional regulator
RG45_RS13845	COG3119	arylsulfatase activity
RG45_RS13850	COG0641	radical SAM
RG45_RS13855	COG4178	(ABC) transporter
RG45_RS13860	COG4771	TonB-dependent receptor
RG45_RS13865	COG0612	Peptidase, M16
RG45_RS13875	COG0076	glutamate decarboxylase activity
RG45_RS13880	COG0531	amino acid
RG45_RS13885	COG1649	PFAM Uncharacterised BCR, COG1649
RG45_RS13890	COG3706	GGDEF domain
RG45_RS13895	COG2200	EAL domain
RG45_RS13895	COG2199	diguanylate cyclase activity
RG45_RS13895	COG2202	Pas domain
RG45_RS13900	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RG45_RS13905	COG0747	negative chemotaxis
RG45_RS13910	COG0601	transmembrane transport
RG45_RS13915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG45_RS13920	COG0444	Belongs to the ABC transporter superfamily
RG45_RS13925	COG4608	Belongs to the ABC transporter superfamily
RG45_RS13930	COG1764	response to oxidative stress
RG45_RS13955	COG1064	alcohol dehydrogenase
RG45_RS13960	COG3093	addiction module antidote protein HigA
RG45_RS13970	COG2864	formate dehydrogenase
RG45_RS13975	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS13985	COG0697	spore germination
RG45_RS13990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG45_RS13995	COG4886	Leucine-rich repeat (LRR) protein
RG45_RS14000	COG2223	nitrite transmembrane transporter activity
RG45_RS14005	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG45_RS14010	COG1140	nitrate reductase beta subunit
RG45_RS14015	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG45_RS14020	COG2181	nitrate reductase activity
RG45_RS14025	COG0384	phenazine biosynthesis protein PhzF
RG45_RS14030	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RG45_RS14035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG45_RS14055	COG0625	glutathione transferase activity
RG45_RS14060	COG1113	amino acid transport
RG45_RS14065	COG3391	amine dehydrogenase activity
RG45_RS14080	COG4772	TonB-dependent receptor
RG45_RS14085	COG1802	Transcriptional regulator
RG45_RS14090	COG2130	NADP-dependent
RG45_RS14100	COG1247	-acetyltransferase
RG45_RS14105	COG3238	Protein conserved in bacteria
RG45_RS14135	COG1177	transmembrane transport
RG45_RS14140	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG45_RS14145	COG3842	ATPase activity
RG45_RS14150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG45_RS14155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG45_RS14160	COG1598	PFAM Uncharacterised protein family UPF0150
RG45_RS14165	COG1724	mRNA binding
RG45_RS14175	COG0826	peptidase U32
RG45_RS14180	COG1396	sequence-specific DNA binding
RG45_RS14185	COG3135	benzoate transporter
RG45_RS14190	COG0675	Transposase, IS605 OrfB family
RG45_RS14205	COG0500	methyltransferase
RG45_RS14210	COG1275	C4-dicarboxylate transporter malic acid transport protein
RG45_RS14215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG45_RS14220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG45_RS14225	COG2841	Protein conserved in bacteria
RG45_RS14245	COG5383	Protein conserved in bacteria
RG45_RS14250	COG0583	DNA-binding transcription factor activity
RG45_RS14255	COG0840	transmembrane signaling receptor activity
RG45_RS14260	COG2963	transposase activity
RG45_RS14265	COG2801	Transposase and inactivated derivatives
RG45_RS14280	COG3038	cytochrome b561
RG45_RS14285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG45_RS14290	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS14295	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG45_RS14300	COG1643	Atp-dependent helicase
RG45_RS14310	COG0671	phosphoesterase, PA-phosphatase related
RG45_RS14310	COG2453	phosphatase
RG45_RS14315	COG2267	carboxylic ester hydrolase activity
RG45_RS14335	COG3784	Protein of unknown function (DUF1318)
RG45_RS14345	COG2911	Protein conserved in bacteria
RG45_RS14350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RG45_RS14355	COG3187	Heat shock protein
RG45_RS14360	COG3042	response to heat
RG45_RS14365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG45_RS14365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RG45_RS14365	COG1013	pyruvate-flavodoxin oxidoreductase activity
RG45_RS14365	COG0674	pyruvate-flavodoxin oxidoreductase activity
RG45_RS14375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG45_RS14380	COG0589	response to stress
RG45_RS14390	COG1121	(ABC) transporter
RG45_RS14395	COG1475	DNA binding
RG45_RS14405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG45_RS14415	COG3772	lysozyme
RG45_RS14495	COG1846	Transcriptional regulator
RG45_RS14500	COG1484	DNA-dependent DNA replication
RG45_RS14505	COG3756	Protein conserved in bacteria
RG45_RS14520	COG1396	sequence-specific DNA binding
RG45_RS14560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG45_RS14565	COG3723	Recombinational DNA repair protein, rece pathway
RG45_RS14585	COG0582	viral genome integration into host DNA
RG45_RS14595	COG0513	Belongs to the DEAD box helicase family
RG45_RS14610	COG3706	GGDEF domain
RG45_RS14615	COG2840	Smr protein MutS2
RG45_RS14625	COG0583	DNA-binding transcription factor activity
RG45_RS14630	COG1473	amidohydrolase
RG45_RS14635	COG1473	amidohydrolase
RG45_RS14645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RG45_RS14650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG45_RS14655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG45_RS14660	COG0589	response to stress
RG45_RS14665	COG3182	Iron-regulated membrane protein
RG45_RS14670	COG0668	transmembrane transport
RG45_RS14675	COG4166	transmembrane transport
RG45_RS14685	COG0583	DNA-binding transcription factor activity
RG45_RS14710	COG1073	alpha beta
RG45_RS14715	COG0702	epimerase
RG45_RS14720	COG2866	Carboxypeptidase
RG45_RS14725	COG4948	Mandelate Racemase Muconate Lactonizing
RG45_RS14730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RG45_RS14735	COG3283	Transcriptional regulator of aromatic amino acids metabolism
RG45_RS14745	COG3106	COG3106 Predicted ATPase
RG45_RS14750	COG1609	Transcriptional regulator
RG45_RS14760	COG3842	ATPase activity
RG45_RS14765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG45_RS14770	COG1554	hydrolase, family 65, central catalytic
RG45_RS14775	COG0673	inositol 2-dehydrogenase activity
RG45_RS14780	COG1082	Xylose isomerase domain protein TIM barrel
RG45_RS14785	COG1063	alcohol dehydrogenase
RG45_RS14790	COG0395	ABC-type sugar transport system, permease component
RG45_RS14795	COG1175	transmembrane transport
RG45_RS14800	COG1653	transport
RG45_RS14805	COG0366	Alpha amylase catalytic
RG45_RS14810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG45_RS14820	COG1983	PspC domain protein
RG45_RS14830	COG1842	Phage shock protein A
RG45_RS14835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RG45_RS14840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG45_RS14845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RG45_RS14850	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS14860	COG1396	sequence-specific DNA binding
RG45_RS14860	COG1917	Cupin 2, conserved barrel domain protein
RG45_RS14865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RG45_RS14870	COG0174	glutamine synthetase
RG45_RS14875	COG0531	amino acid
RG45_RS14890	COG4166	transmembrane transport
RG45_RS14895	COG4168	peptide transport system, permease
RG45_RS14900	COG4171	peptide transport system, permease
RG45_RS14905	COG4172	Belongs to the ABC transporter superfamily
RG45_RS14910	COG4172	Belongs to the ABC transporter superfamily
RG45_RS14915	COG2852	Protein conserved in bacteria
RG45_RS14920	COG3385	transposase activity
RG45_RS14930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RG45_RS14935	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG45_RS14935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG45_RS14950	COG5001	Diguanylate cyclase
RG45_RS14960	COG1349	DNA-binding transcription factor activity
RG45_RS14970	COG0023	Translation Initiation Factor
RG45_RS14980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RG45_RS14985	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RG45_RS14990	COG0671	phosphoesterase, PA-phosphatase related
RG45_RS15000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG45_RS15040	COG0583	DNA-binding transcription factor activity
RG45_RS15050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG45_RS15060	COG0616	signal peptide processing
RG45_RS15070	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS15075	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RG45_RS15080	COG1187	pseudouridine synthase activity
RG45_RS15085	COG4907	membrane protein (DUF2207)
RG45_RS15090	COG0009	L-threonylcarbamoyladenylate synthase
RG45_RS15095	COG0613	PHP domain protein
RG45_RS15100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG45_RS15105	COG0512	Glutamine amidotransferase of anthranilate synthase
RG45_RS15105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG45_RS15110	COG0135	phosphoribosylanthranilate isomerase activity
RG45_RS15110	COG0134	indole-3-glycerol-phosphate synthase activity
RG45_RS15125	COG3729	General stress protein
RG45_RS15130	COG3685	Protein conserved in bacteria
RG45_RS15135	COG3685	Protein conserved in bacteria
RG45_RS15140	COG3047	cAMP biosynthetic process
RG45_RS15160	COG1607	acyl-coa hydrolase
RG45_RS15165	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RG45_RS15170	COG2350	Protein conserved in bacteria
RG45_RS15175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG45_RS15195	COG4608	Belongs to the ABC transporter superfamily
RG45_RS15200	COG0444	Belongs to the ABC transporter superfamily
RG45_RS15205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG45_RS15210	COG0601	transmembrane transport
RG45_RS15215	COG4166	transmembrane transport
RG45_RS15225	COG2095	MarC family integral membrane protein
RG45_RS15230	COG1454	alcohol dehydrogenase
RG45_RS15230	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS15250	COG1435	thymidine kinase activity
RG45_RS15260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG45_RS15265	COG0745	RESPONSE REGULATOR receiver
RG45_RS15270	COG1752	Esterase of the alpha-beta hydrolase superfamily
RG45_RS15280	COG0788	formyltetrahydrofolate deformylase activity
RG45_RS15305	COG2181	nitrate reductase activity
RG45_RS15310	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG45_RS15315	COG1140	nitrate reductase beta subunit
RG45_RS15320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG45_RS15325	COG2223	nitrite transmembrane transporter activity
RG45_RS15335	COG3850	Histidine kinase
RG45_RS15340	COG2197	response regulator
RG45_RS15345	COG4932	domain protein
RG45_RS15350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RG45_RS15355	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RG45_RS15360	COG4572	Cation transport regulator
RG45_RS15365	COG0387	Pfam Sodium calcium exchanger
RG45_RS15395	COG2912	Transglutaminase-like superfamily
RG45_RS15400	COG3094	Invasion gene expression up-regulator, SirB
RG45_RS15405	COG2890	protein-(glutamine-N5) methyltransferase activity
RG45_RS15430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RG45_RS15435	COG0659	secondary active sulfate transmembrane transporter activity
RG45_RS15450	COG0012	GTP binding
RG45_RS15465	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS15470	COG3284	Transcriptional regulator
RG45_RS15475	COG2376	Dihydroxyacetone kinase
RG45_RS15480	COG1461	Dihydroxyacetone kinase
RG45_RS15485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG45_RS15485	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RG45_RS15485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS15510	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RG45_RS15525	COG1619	proteins homologs of microcin C7 resistance protein MccF
RG45_RS15535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG45_RS15545	COG2719	SpoVR family
RG45_RS15560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RG45_RS15565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RG45_RS15570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RG45_RS15585	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG45_RS15615	COG2894	cell division
RG45_RS15675	COG2200	EAL domain
RG45_RS15695	COG2200	EAL domain
RG45_RS15720	COG2200	EAL domain
RG45_RS15725	COG0789	Transcriptional regulator
RG45_RS15730	COG5562	phage envelope protein
RG45_RS15745	COG0538	isocitrate dehydrogenase activity
RG45_RS15750	COG1187	pseudouridine synthase activity
RG45_RS15770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RG45_RS15775	COG0745	RESPONSE REGULATOR receiver
RG45_RS15780	COG2205	protein histidine kinase activity
RG45_RS15785	COG2850	peptidyl-arginine hydroxylation
RG45_RS15810	COG1177	transmembrane transport
RG45_RS15815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG45_RS15820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RG45_RS15830	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG45_RS15835	COG1136	(ABC) transporter
RG45_RS15840	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG45_RS15845	COG4763	Acyl-transferase
RG45_RS15850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RG45_RS15855	COG1388	LysM domain
RG45_RS15855	COG1376	ErfK ybiS ycfS ynhG family protein
RG45_RS15865	COG1309	transcriptional regulator
RG45_RS15870	COG3134	Outer membrane lipoprotein
RG45_RS15875	COG1252	NADH dehydrogenase
RG45_RS15895	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
RG45_RS15900	COG5633	Lipoprotein
RG45_RS15905	COG0537	adenosine 5'-monophosphoramidase activity
RG45_RS15910	COG4773	Receptor
RG45_RS15915	COG1263	PTS System
RG45_RS15915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS15920	COG0084	hydrolase, TatD family'
RG45_RS15925	COG0470	DNA polymerase III
RG45_RS15935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RG45_RS15940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG45_RS15945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG45_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS15960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RG45_RS15980	COG1399	metal-binding, possibly nucleic acid-binding protein
RG45_RS15985	COG0424	maF-like protein
RG45_RS15990	COG0564	pseudouridine synthase activity
RG45_RS16000	COG1530	ribonuclease E activity
RG45_RS16005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG45_RS16010	COG1256	bacterial-type flagellum assembly
RG45_RS16015	COG1705	Flagellar rod assembly protein muramidase FlgJ
RG45_RS16015	COG3951	Flagellar rod assembly protein muramidase FlgJ
RG45_RS16030	COG4786	Flagellar basal body rod
RG45_RS16035	COG4787	bacterial-type flagellum-dependent cell motility
RG45_RS16040	COG1749	Flagellar hook protein flgE
RG45_RS16045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RG45_RS16050	COG1558	bacterial-type flagellum-dependent cell motility
RG45_RS16055	COG1815	bacterial-type flagellum-dependent cell motility
RG45_RS16060	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RG45_RS16065	COG2747	anti-sigma28 factor FlgM
RG45_RS16070	COG3418	PFAM FlgN family protein
RG45_RS16075	COG0728	peptidoglycan biosynthetic process
RG45_RS16080	COG0673	inositol 2-dehydrogenase activity
RG45_RS16090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG45_RS16100	COG2999	glutathione oxidoreductase activity
RG45_RS16140	COG3038	cytochrome b561
RG45_RS16145	COG2353	YceI-like domain
RG45_RS16155	COG1560	Kdo2-lipid A biosynthetic process
RG45_RS16175	COG5645	(Lipo)protein
RG45_RS16180	COG2943	transferase activity, transferring hexosyl groups
RG45_RS16195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG45_RS16200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG45_RS16235	COG2197	response regulator
RG45_RS16250	COG1462	curli production assembly transport component CsgG
RG45_RS16260	COG3381	protein complex oligomerization
RG45_RS16300	COG2801	Transposase and inactivated derivatives
RG45_RS16305	COG3706	GGDEF domain
RG45_RS16325	COG0457	Tetratricopeptide repeat
RG45_RS16350	COG0457	Tetratricopeptide repeat
RG45_RS16355	COG1649	PFAM Uncharacterised BCR, COG1649
RG45_RS16355	COG0726	polysaccharide deacetylase
RG45_RS16360	COG1215	transferase activity, transferring glycosyl groups
RG45_RS16365	COG3658	cytochrome
RG45_RS16370	COG1702	phosphate starvation-inducible protein PhoH
RG45_RS16380	COG2837	iron assimilation
RG45_RS16385	COG2822	iron ion transport
RG45_RS16400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG45_RS16415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG45_RS16415	COG0506	proline dehydrogenase activity
RG45_RS16415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG45_RS16420	COG1309	transcriptional regulator
RG45_RS16455	COG2233	PERMEase
RG45_RS16465	COG3729	General stress protein
RG45_RS16510	COG0243	molybdopterin cofactor binding
RG45_RS16515	COG3005	denitrification pathway
RG45_RS16520	COG0745	RESPONSE REGULATOR receiver
RG45_RS16525	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS16530	COG2198	Histidine kinase
RG45_RS16530	COG0784	Response regulator, receiver
RG45_RS16530	COG2205	protein histidine kinase activity
RG45_RS16535	COG0348	domain, Protein
RG45_RS16555	COG1278	Cold shock
RG45_RS16560	COG1278	Cold shock
RG45_RS16580	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG45_RS16585	COG1596	polysaccharide export
RG45_RS16590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG45_RS16595	COG3206	protein involved in exopolysaccharide biosynthesis
RG45_RS16595	COG0489	protein tyrosine kinase activity
RG45_RS16610	COG3206	protein involved in exopolysaccharide biosynthesis
RG45_RS16610	COG0489	protein tyrosine kinase activity
RG45_RS16625	COG1294	oxidase, subunit
RG45_RS16630	COG1271	oxidase subunit
RG45_RS16635	COG1773	rubredoxin
RG45_RS16640	COG1999	signal sequence binding
RG45_RS16645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG45_RS16650	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RG45_RS16655	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG45_RS16660	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG45_RS16670	COG0670	Belongs to the BI1 family
RG45_RS16675	COG2920	part of a sulfur-relay system
RG45_RS16680	COG1254	Belongs to the acylphosphatase family
RG45_RS16695	COG1832	CoA-binding protein
RG45_RS16715	COG0210	DNA helicase
RG45_RS16720	COG3304	Inner membrane component domain
RG45_RS16725	COG1289	transmembrane transporter activity
RG45_RS16730	COG3070	regulator of competence-specific genes
RG45_RS16745	COG2885	chlorophyll binding
RG45_RS16745	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG45_RS16755	COG1067	ATP-dependent peptidase activity
RG45_RS16765	COG3130	regulation of translation
RG45_RS16770	COG3009	Protein conserved in bacteria
RG45_RS16775	COG3008	intermembrane lipid transfer
RG45_RS16775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG45_RS16780	COG2995	paraquat-inducible protein a
RG45_RS16785	COG0488	(ABC) transporter
RG45_RS16795	COG3217	Mosc domain protein beta barrel domain protein
RG45_RS16795	COG0633	Ferredoxin
RG45_RS16810	COG3121	Chaperone
RG45_RS16815	COG3539	Fimbrial protein
RG45_RS16820	COG3539	Fimbrial protein
RG45_RS16825	COG3539	Fimbrial protein
RG45_RS16830	COG3188	usher protein
RG45_RS16835	COG3121	Chaperone
RG45_RS16860	COG3539	Fimbrial protein
RG45_RS16870	COG0431	NADPH-dependent FMN reductase
RG45_RS16875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RG45_RS16885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG45_RS16890	COG1116	anion transmembrane transporter activity
RG45_RS16895	COG0308	aminopeptidase N
RG45_RS16920	COG1448	Aminotransferase
RG45_RS16925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RG45_RS16930	COG3108	Peptidase M15
RG45_RS16940	COG2989	Protein conserved in bacteria
RG45_RS16950	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RG45_RS16960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RG45_RS16965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG45_RS16970	COG3173	Aminoglycoside phosphotransferase
RG45_RS16985	COG3214	Protein conserved in bacteria
RG45_RS16995	COG1132	(ABC) transporter
RG45_RS17000	COG0658	competence protein
RG45_RS17000	COG2333	competence protein COMEC
RG45_RS17010	COG0539	negative regulation of cytoplasmic translation
RG45_RS17020	COG0501	Belongs to the peptidase M48B family
RG45_RS17035	COG2323	membrane
RG45_RS17040	COG1944	ATP diphosphatase activity
RG45_RS17045	COG2116	formate transmembrane transporter activity
RG45_RS17050	COG1882	Formate acetyltransferase
RG45_RS17055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG45_RS17065	COG0583	DNA-binding transcription factor activity
RG45_RS17070	COG0531	amino acid
RG45_RS17080	COG1335	isochorismatase
RG45_RS17085	COG3302	dmso reductase anchor subunit
RG45_RS17090	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS17095	COG0243	molybdopterin cofactor binding
RG45_RS17105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RG45_RS17115	COG1674	ftsk spoiiie
RG45_RS17115	COG1178	ABC-type Fe3 transport system permease component
RG45_RS17120	COG1522	sequence-specific DNA binding
RG45_RS17130	COG0492	ferredoxin-NADP+ reductase activity
RG45_RS17135	COG4988	ABC transporter
RG45_RS17140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RG45_RS17165	COG0542	response to heat
RG45_RS17175	COG1278	Cold shock
RG45_RS17180	COG1136	(ABC) transporter
RG45_RS17180	COG0577	efflux transmembrane transporter activity
RG45_RS17185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS17190	COG2990	Protein conserved in bacteria
RG45_RS17195	COG3593	DNA synthesis involved in DNA repair
RG45_RS17215	COG2431	L-lysine efflux transmembrane transporter activity
RG45_RS17225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG45_RS17230	COG0028	Belongs to the TPP enzyme family
RG45_RS17235	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RG45_RS17240	COG0702	epimerase
RG45_RS17245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG45_RS17250	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG45_RS17265	COG1126	abc transporter atp-binding protein
RG45_RS17270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS17275	COG4215	(ABC) transporter
RG45_RS17280	COG4160	amino acid transport
RG45_RS17285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS17300	COG1177	transmembrane transport
RG45_RS17305	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG45_RS17310	COG3842	ATPase activity
RG45_RS17315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG45_RS17335	COG0778	Nitroreductase
RG45_RS17345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG45_RS17400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG45_RS17500	COG4695	Portal protein
RG45_RS17535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG45_RS17580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RG45_RS17585	COG3226	Transcriptional regulator
RG45_RS17590	COG0738	Major facilitator superfamily
RG45_RS17595	COG0561	phosphatase activity
RG45_RS17605	COG2814	Major facilitator Superfamily
RG45_RS17610	COG0671	phosphoesterase, PA-phosphatase related
RG45_RS17615	COG1349	DNA-binding transcription factor activity
RG45_RS17620	COG1686	Belongs to the peptidase S11 family
RG45_RS17625	COG0625	glutathione transferase activity
RG45_RS17655	COG2199	diguanylate cyclase activity
RG45_RS17660	COG2200	EAL domain
RG45_RS17675	COG0747	negative chemotaxis
RG45_RS17685	COG1446	asparaginase
RG45_RS17690	COG0303	'Molybdopterin
RG45_RS17695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG45_RS17700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG45_RS17705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG45_RS17710	COG1882	Formate acetyltransferase
RG45_RS17715	COG0561	phosphatase activity
RG45_RS17725	COG0488	(ABC) transporter
RG45_RS17730	COG1376	ErfK ybiS ycfS ynhG family protein
RG45_RS17735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG45_RS17740	COG1321	iron dependent repressor
RG45_RS17750	COG2194	sulfuric ester hydrolase activity
RG45_RS17755	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG45_RS17760	COG5006	permease, DMT superfamily
RG45_RS17785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS17790	COG0765	amino acid transport
RG45_RS17795	COG1126	abc transporter atp-binding protein
RG45_RS17805	COG0668	transmembrane transport
RG45_RS17820	COG4774	siderophore transport
RG45_RS17825	COG3385	transposase activity
RG45_RS17840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG45_RS17850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG45_RS17855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG45_RS17860	COG1199	ATP-dependent helicase activity
RG45_RS17870	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RG45_RS17875	COG0513	Belongs to the DEAD box helicase family
RG45_RS17880	COG1309	transcriptional regulator
RG45_RS17890	COG1131	(ABC) transporter
RG45_RS17895	COG0842	Transport permease protein
RG45_RS17900	COG0842	Transport permease protein
RG45_RS17910	COG3568	Endonuclease Exonuclease Phosphatase
RG45_RS17915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG45_RS17920	COG0392	lysyltransferase activity
RG45_RS17925	COG0670	Belongs to the BI1 family
RG45_RS17930	COG0670	Belongs to the BI1 family
RG45_RS17935	COG0314	molybdopterin synthase activity
RG45_RS17940	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RG45_RS17950	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG45_RS17960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RG45_RS17970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG45_RS17975	COG2226	methyltransferase
RG45_RS17990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RG45_RS17995	COG1881	PFAM PEBP family protein
RG45_RS18005	COG2199	diguanylate cyclase activity
RG45_RS18010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG45_RS18015	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG45_RS18035	COG0582	viral genome integration into host DNA
RG45_RS18040	COG4677	pectinesterase activity
RG45_RS18075	COG0501	Belongs to the peptidase M48B family
RG45_RS18105	COG0542	response to heat
RG45_RS18110	COG0071	Belongs to the small heat shock protein (HSP20) family
RG45_RS18200	COG0471	metal ion transport
RG45_RS18205	COG2828	Protein conserved in bacteria
RG45_RS18210	COG0583	DNA-binding transcription factor activity
RG45_RS18220	COG0561	phosphatase activity
RG45_RS18225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RG45_RS18230	COG4149	molybdate abc transporter
RG45_RS18235	COG0725	ABC transporter, periplasmic molybdate-binding protein
RG45_RS18250	COG3585	molybdate ion transport
RG45_RS18250	COG2005	Transcriptional regulator
RG45_RS18255	COG1119	ATPase activity
RG45_RS18260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RG45_RS18265	COG1085	galactose-1-phosphate uridylyltransferase
RG45_RS18275	COG2017	converts alpha-aldose to the beta-anomer
RG45_RS18285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG45_RS18300	COG1230	cation diffusion facilitator family transporter
RG45_RS18305	COG3201	nicotinamide mononucleotide transporter
RG45_RS18350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RG45_RS18355	COG2885	chlorophyll binding
RG45_RS18365	COG3064	Membrane
RG45_RS18370	COG0848	biopolymer transport protein
RG45_RS18375	COG0811	peptide transport
RG45_RS18380	COG0824	Thioesterase
RG45_RS18385	COG3790	cyd operon protein YbgE
RG45_RS18390	COG4890	Cyd operon protein YbgT
RG45_RS18395	COG1294	oxidase, subunit
RG45_RS18400	COG1271	oxidase subunit
RG45_RS18410	COG0383	alpha-mannosidase activity
RG45_RS18435	COG0383	alpha-mannosidase activity
RG45_RS18440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS18440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS18440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG45_RS18445	COG2188	Transcriptional regulator
RG45_RS18450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG45_RS18460	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG45_RS18465	COG0567	Dehydrogenase, E1 component
RG45_RS18475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG45_RS18480	COG1053	succinate dehydrogenase
RG45_RS18485	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RG45_RS18490	COG2009	succinate dehydrogenase
RG45_RS18510	COG0372	Belongs to the citrate synthase family
RG45_RS18515	COG3539	Fimbrial protein
RG45_RS18540	COG3121	Chaperone
RG45_RS18545	COG3539	Fimbrial protein
RG45_RS18550	COG3180	Ammonia monooxygenase
RG45_RS18565	COG1984	allophanate hydrolase subunit 2
RG45_RS18570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RG45_RS18575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RG45_RS18580	COG3104	oligopeptide transport
RG45_RS18585	COG0415	Belongs to the DNA photolyase family
RG45_RS18590	COG3272	Protein of unknown function (DUF1722)
RG45_RS18595	COG5433	transposase activity
RG45_RS18605	COG5433	transposase activity
RG45_RS18620	COG3209	COG3209 Rhs family protein
RG45_RS18650	COG2205	protein histidine kinase activity
RG45_RS18655	COG0745	RESPONSE REGULATOR receiver
RG45_RS18670	COG1982	Orn Lys Arg decarboxylase major
RG45_RS18675	COG0531	amino acid
RG45_RS18695	COG0033	Phosphoglucomutase
RG45_RS18700	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RG45_RS18705	COG0596	Alpha beta hydrolase
RG45_RS18715	COG0716	FMN binding
RG45_RS18730	COG0735	belongs to the Fur family
RG45_RS18770	COG2190	(PTS) system
RG45_RS18770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS18770	COG1263	PTS System
RG45_RS18780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG45_RS18785	COG1940	carbohydrate kinase activity
RG45_RS18785	COG1846	Transcriptional regulator
RG45_RS18790	COG0647	UMP catabolic process
RG45_RS18795	COG0367	asparagine synthase
RG45_RS18845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG45_RS18855	COG1702	phosphate starvation-inducible protein PhoH
RG45_RS18865	COG4535	Mg2 and Co2 transporter CorC
RG45_RS18870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RG45_RS18880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG45_RS18885	COG0765	amino acid transport
RG45_RS18890	COG0765	amino acid transport
RG45_RS18895	COG1126	abc transporter atp-binding protein
RG45_RS18905	COG2888	peptidyl-tyrosine sulfation
RG45_RS18920	COG1466	dna polymerase III delta subunit
RG45_RS18930	COG0406	alpha-ribazole phosphatase activity
RG45_RS18935	COG0799	negative regulation of ribosome biogenesis
RG45_RS18945	COG0768	penicillin binding
RG45_RS18950	COG0772	Belongs to the SEDS family
RG45_RS18955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG45_RS18960	COG1686	Belongs to the peptidase S11 family
RG45_RS18980	COG0583	DNA-binding transcription factor activity
RG45_RS18995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG45_RS19000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG45_RS19025	COG3069	C4-dicarboxylate transmembrane transporter activity
RG45_RS19030	COG4565	transcriptional regulatory protein
RG45_RS19035	COG3290	protein histidine kinase activity
RG45_RS19040	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RG45_RS19050	COG2301	Belongs to the HpcH HpaI aldolase family
RG45_RS19055	COG3051	citrate lyase alpha subunit
RG45_RS19070	COG0471	metal ion transport
RG45_RS19075	COG3719	Belongs to the RNase T2 family
RG45_RS19085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG45_RS19100	COG0589	response to stress
RG45_RS19105	COG3634	alkyl hydroperoxide reductase activity
RG45_RS19110	COG0450	alkyl hydroperoxide reductase
RG45_RS19115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG45_RS19125	COG0583	DNA-binding transcription factor activity
RG45_RS19130	COG3969	phosphoadenosine phosphosulfate
RG45_RS19135	COG1475	DNA binding
RG45_RS19140	COG0436	Aminotransferase
RG45_RS19145	COG0371	Dehydrogenase
RG45_RS19150	COG2879	small protein
RG45_RS19155	COG1966	Carbon starvation protein
RG45_RS19160	COG2050	protein possibly involved in aromatic compounds catabolism
RG45_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS19170	COG3433	isochorismatase activity
RG45_RS19170	COG1535	isochorismatase
RG45_RS19175	COG1021	2,3-dihydroxybenzoate-AMP ligase
RG45_RS19180	COG1169	isochorismate synthase
RG45_RS19190	COG4592	Periplasmic binding protein
RG45_RS19200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG45_RS19205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG45_RS19210	COG1120	ATPase activity
RG45_RS19215	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG45_RS19240	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG45_RS19245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG45_RS19245	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RG45_RS19250	COG3251	PFAM MbtH domain protein
RG45_RS19255	COG2382	esterase
RG45_RS19260	COG4771	TonB-dependent receptor
RG45_RS19270	COG2977	Belongs to the P-Pant transferase superfamily
RG45_RS19280	COG3385	transposase activity
RG45_RS19290	COG2801	Transposase and inactivated derivatives
RG45_RS19295	COG2963	transposase activity
RG45_RS19315	COG2315	Protein conserved in bacteria
RG45_RS19320	COG0778	Nitroreductase
RG45_RS19325	COG0668	transmembrane transport
RG45_RS19330	COG1113	amino acid transport
RG45_RS19335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG45_RS19340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS19345	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS19350	COG1538	Outer membrane efflux protein
RG45_RS19360	COG0745	RESPONSE REGULATOR receiver
RG45_RS19365	COG5002	protein histidine kinase activity
RG45_RS19440	COG2197	response regulator
RG45_RS19445	COG3539	Fimbrial protein
RG45_RS19450	COG3539	Fimbrial protein
RG45_RS19455	COG3188	usher protein
RG45_RS19475	COG3188	usher protein
RG45_RS19480	COG3121	Chaperone
RG45_RS19485	COG3539	Fimbrial protein
RG45_RS19495	COG2501	S4 domain
RG45_RS19500	COG1988	membrane-bound metal-dependent
RG45_RS19510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG45_RS19525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RG45_RS19530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RG45_RS19535	COG0549	Belongs to the carbamate kinase family
RG45_RS19550	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG45_RS19560	COG3257	ureidoglycine aminohydrolase activity
RG45_RS19565	COG1929	Belongs to the glycerate kinase type-1 family
RG45_RS19570	COG2233	PERMEase
RG45_RS19580	COG1953	Uracil, thiamine, allantoin
RG45_RS19605	COG1953	Uracil, thiamine, allantoin
RG45_RS19610	COG2084	Dehydrogenase
RG45_RS19615	COG3622	Belongs to the hyi family
RG45_RS19620	COG3960	tartronate-semialdehyde synthase activity
RG45_RS19625	COG1414	Transcriptional regulator
RG45_RS19635	COG0583	DNA-binding transcription factor activity
RG45_RS19650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RG45_RS19655	COG4181	ATPase activity
RG45_RS19660	COG2755	lipolytic protein G-D-S-L family
RG45_RS19665	COG0300	oxidoreductase activity
RG45_RS19670	COG3118	belongs to the thioredoxin family
RG45_RS19675	COG0390	transport system, permease component
RG45_RS19680	COG4619	ABC transporter
RG45_RS19685	COG0330	HflC and HflK could
RG45_RS19690	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG45_RS19695	COG0789	Transcriptional regulator
RG45_RS19705	COG0531	amino acid
RG45_RS19715	COG2217	Heavy metal translocating P-type atpase
RG45_RS19740	COG3093	addiction module antidote protein HigA
RG45_RS19745	COG3735	TraB family
RG45_RS19750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG45_RS19755	COG0737	Belongs to the 5'-nucleotidase family
RG45_RS19765	COG2223	nitrite transmembrane transporter activity
RG45_RS19770	COG4651	solute:proton antiporter activity
RG45_RS19770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG45_RS19775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG45_RS19810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RG45_RS19825	COG2832	Protein of unknown function (DUF454)
RG45_RS19830	COG3923	Primosomal replication protein n
RG45_RS19840	COG3264	Mechanosensitive ion channel
RG45_RS19840	COG1196	nuclear chromosome segregation
RG45_RS19850	COG1309	transcriptional regulator
RG45_RS19855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG45_RS19860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG45_RS19875	COG0110	maltose O-acetyltransferase activity
RG45_RS19885	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG45_RS19905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG45_RS19910	COG5507	3-demethylubiquinone-9 3-methyltransferase
RG45_RS19920	COG3695	enzyme binding
RG45_RS19925	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RG45_RS19930	COG1946	Acyl-CoA thioesterase
RG45_RS19935	COG0004	ammonium transporteR
RG45_RS19940	COG0347	Belongs to the P(II) protein family
RG45_RS19945	COG1132	(ABC) transporter
RG45_RS19950	COG1132	(ABC) transporter
RG45_RS19955	COG1522	sequence-specific DNA binding
RG45_RS19965	COG4533	DNA binding
RG45_RS19975	COG0824	Thioesterase
RG45_RS19980	COG1555	photosystem II stabilization
RG45_RS19985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG45_RS19990	COG0776	regulation of translation
RG45_RS19995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RG45_RS20020	COG0271	Belongs to the BolA IbaG family
RG45_RS20030	COG3056	Lipoprotein
RG45_RS20035	COG2223	nitrite transmembrane transporter activity
RG45_RS20040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RG45_RS20045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RG45_RS20050	COG1845	cytochrome c oxidase, subunit III
RG45_RS20055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RG45_RS20065	COG2814	Major facilitator Superfamily
RG45_RS20075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RG45_RS20080	COG0693	protein deglycase activity
RG45_RS20095	COG0142	geranyltranstransferase activity
RG45_RS20105	COG0667	Aldo Keto reductase
RG45_RS20110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RG45_RS20115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RG45_RS20130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG45_RS20130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG45_RS20140	COG4238	major outer membrane lipoprotein
RG45_RS20145	COG3248	Nucleoside-binding outer membrane protein
RG45_RS20150	COG1403	HNH endonuclease
RG45_RS20155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG45_RS20160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG45_RS20165	COG1862	Preprotein translocase
RG45_RS20185	COG0366	Alpha amylase catalytic
RG45_RS20190	COG1113	amino acid transport
RG45_RS20195	COG1114	Component of the transport system for branched-chain amino acids
RG45_RS20200	COG5002	protein histidine kinase activity
RG45_RS20205	COG0745	RESPONSE REGULATOR receiver
RG45_RS20210	COG0420	3'-5' exonuclease activity
RG45_RS20215	COG0419	ATPase involved in DNA repair
RG45_RS20220	COG2814	Major facilitator Superfamily
RG45_RS20225	COG1940	carbohydrate kinase activity
RG45_RS20250	COG4126	flavin adenine dinucleotide binding
RG45_RS20275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RG45_RS20280	COG3706	GGDEF domain
RG45_RS20290	COG1785	Belongs to the alkaline phosphatase family
RG45_RS20305	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG45_RS20325	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RG45_RS20335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG45_RS20340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG45_RS20345	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS20350	COG3468	outer membrane autotransporter barrel domain protein
RG45_RS20380	COG0113	porphobilinogen synthase activity
RG45_RS20385	COG2175	clavaminate synthase activity
RG45_RS20390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG45_RS20395	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RG45_RS20400	COG4521	taurine ABC transporter
RG45_RS20410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RG45_RS20415	COG1215	transferase activity, transferring glycosyl groups
RG45_RS20450	COG3122	Protein conserved in bacteria
RG45_RS20455	COG2814	Major facilitator Superfamily
RG45_RS20500	COG1414	Transcriptional regulator
RG45_RS20505	COG1609	Transcriptional regulator
RG45_RS20520	COG2223	nitrite transmembrane transporter activity
RG45_RS20525	COG0110	maltose O-acetyltransferase activity
RG45_RS20530	COG2807	transmembrane transport
RG45_RS20540	COG0288	reversible hydration of carbon dioxide
RG45_RS20545	COG0583	DNA-binding transcription factor activity
RG45_RS20550	COG0402	S-adenosylhomocysteine deaminase activity
RG45_RS20555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RG45_RS20570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG45_RS20575	COG2079	MmgE PrpD family protein
RG45_RS20580	COG0372	Belongs to the citrate synthase family
RG45_RS20590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RG45_RS20595	COG3829	transcription factor binding
RG45_RS20605	COG1280	lysine exporter protein (LysE YggA)
RG45_RS20645	COG0666	response to abiotic stimulus
RG45_RS20665	COG2200	EAL domain
RG45_RS20665	COG2771	luxR family
RG45_RS20670	COG2801	Transposase and inactivated derivatives
RG45_RS20685	COG0583	DNA-binding transcription factor activity
RG45_RS20690	COG1012	belongs to the aldehyde dehydrogenase family
RG45_RS20695	COG2066	Belongs to the glutaminase family
RG45_RS20705	COG2199	diguanylate cyclase activity
RG45_RS20725	COG3781	membrane
RG45_RS20775	COG3210	domain, Protein
RG45_RS20775	COG2911	Protein conserved in bacteria
RG45_RS20800	COG0626	cystathionine gamma-synthase activity
RG45_RS20820	COG1127	ABC transporter
RG45_RS20825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RG45_RS20845	COG0640	Transcriptional regulator
RG45_RS20875	COG1088	dTDP-glucose 4,6-dehydratase activity
RG45_RS20935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG45_RS20975	COG1556	Lactate utilization protein
RG45_RS20980	COG1139	Iron-sulfur cluster binding protein
RG45_RS20985	COG0247	lactate metabolic process
RG45_RS20990	COG2207	Transcriptional regulator
RG45_RS20995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG45_RS21005	COG3059	membrane
RG45_RS21010	COG2207	Transcriptional regulator
RG45_RS21010	COG3708	Transcriptional regulator
RG45_RS21015	COG2373	Large extracellular alpha-helical protein
RG45_RS21015	COG1388	LysM domain
RG45_RS21015	COG4932	domain protein
RG45_RS21070	COG2801	Transposase and inactivated derivatives
RG45_RS21090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG45_RS21110	COG2195	Cleaves the N-terminal amino acid of tripeptides
RG45_RS21120	COG1690	Belongs to the RtcB family
RG45_RS21125	COG0454	-acetyltransferase
RG45_RS21135	COG2161	toxin-antitoxin pair type II binding
RG45_RS21165	COG1943	Transposase
RG45_RS21175	COG0791	NLP P60 protein
RG45_RS21180	COG3077	Addiction module antitoxin, RelB DinJ family
RG45_RS21185	COG3041	Addiction module toxin RelE StbE family
RG45_RS21190	COG3034	peptidoglycan biosynthetic process
RG45_RS21195	COG0121	glutamine amidotransferase
RG45_RS21205	COG1960	acyl-CoA dehydrogenase activity
RG45_RS21215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG45_RS21260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG45_RS21270	COG2226	methyltransferase
RG45_RS21280	COG1388	LysM domain
RG45_RS21280	COG0741	lytic transglycosylase activity
RG45_RS21285	COG2226	methyltransferase
RG45_RS21295	COG0583	DNA-binding transcription factor activity
RG45_RS21300	COG0656	L-ascorbic acid biosynthetic process
RG45_RS21320	COG0656	L-ascorbic acid biosynthetic process
RG45_RS21355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG45_RS21360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RG45_RS21365	COG2011	ABC-type metal ion transport system permease component
RG45_RS21370	COG1464	Belongs to the NlpA lipoprotein family
RG45_RS21380	COG1720	tRNA m6t6A37 methyltransferase activity
RG45_RS21395	COG3015	lipoprotein NlpE involved in copper resistance
RG45_RS21400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG45_RS21405	COG4681	YaeQ
RG45_RS21415	COG4568	rho-dependent transcription termination
RG45_RS21420	COG0037	tRNA processing
RG45_RS21425	COG0346	lactoylglutathione lyase activity
RG45_RS21430	COG1982	Orn Lys Arg decarboxylase major
RG45_RS21440	COG0587	DNA-directed DNA polymerase activity
RG45_RS21465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RG45_RS21470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RG45_RS21480	COG0750	zinc metalloprotease
RG45_RS21485	COG0575	Belongs to the CDS family
RG45_RS21490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RG45_RS21495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RG45_RS21530	COG0024	Methionine aminopeptidase
RG45_RS21545	COG1408	metallophosphoesterase
RG45_RS21555	COG3835	regulator
RG45_RS21560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG45_RS21580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG45_RS21585	COG2860	membrane
RG45_RS21605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG45_RS21610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG45_RS21615	COG1120	ATPase activity
RG45_RS21620	COG4774	siderophore transport
RG45_RS21625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RG45_RS21635	COG1643	Atp-dependent helicase
RG45_RS21640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RG45_RS21650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG45_RS21660	COG0617	tRNA 3'-terminal CCA addition
RG45_RS21665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RG45_RS21675	COG3121	Chaperone
RG45_RS21680	COG3188	usher protein
RG45_RS21685	COG3539	Fimbrial protein
RG45_RS21690	COG3539	Fimbrial protein
RG45_RS21715	COG5464	transposase or invertase
RG45_RS21735	COG0726	polysaccharide deacetylase
RG45_RS21740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS21745	COG0842	Transport permease protein
RG45_RS21750	COG1131	(ABC) transporter
RG45_RS21755	COG0288	reversible hydration of carbon dioxide
RG45_RS21760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RG45_RS21765	COG4993	Dehydrogenase
RG45_RS21770	COG2132	Multicopper oxidase
RG45_RS21795	COG1049	propionate catabolic process, 2-methylcitrate cycle
RG45_RS21805	COG3064	Membrane
RG45_RS21810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG45_RS21815	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG45_RS21820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RG45_RS21830	COG2186	Transcriptional regulator
RG45_RS21840	COG3725	Membrane protein required for beta-lactamase induction
RG45_RS21845	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG45_RS21850	COG0157	Belongs to the NadC ModD family
RG45_RS21860	COG4969	Belongs to the N-Me-Phe pilin family
RG45_RS21865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG45_RS21870	COG1459	type II secretion system
RG45_RS21880	COG0237	dephospho-CoA kinase activity
RG45_RS21895	COG0494	nUDIX hydrolase
RG45_RS21915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RG45_RS21920	COG0849	cell division
RG45_RS21925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RG45_RS21930	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG45_RS21945	COG0772	Belongs to the SEDS family
RG45_RS21950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RG45_RS21960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RG45_RS21965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG45_RS21970	COG0768	penicillin binding
RG45_RS21975	COG3116	cell division
RG45_RS21985	COG2001	Belongs to the MraZ family
RG45_RS21995	COG1609	Transcriptional regulator
RG45_RS22005	COG0440	acetolactate synthase activity
RG45_RS22010	COG0028	Belongs to the TPP enzyme family
RG45_RS22015	COG0583	DNA-binding transcription factor activity
RG45_RS22030	COG0473	3-isopropylmalate dehydrogenase activity
RG45_RS22045	COG2814	Major facilitator Superfamily
RG45_RS22060	COG4143	(ABC) transporter
RG45_RS22065	COG1178	ABC-type Fe3 transport system permease component
RG45_RS22075	COG0586	Pfam SNARE associated Golgi protein
RG45_RS22080	COG4977	sequence-specific DNA binding
RG45_RS22105	COG0235	Class ii aldolase
RG45_RS22110	COG0417	DNA replication proofreading
RG45_RS22120	COG0564	pseudouridine synthase activity
RG45_RS22125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RG45_RS22130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG45_RS22135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG45_RS22160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RG45_RS22175	COG2271	Major facilitator Superfamily
RG45_RS22180	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG45_RS22185	COG0644	oxidoreductase
RG45_RS22240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RG45_RS22245	COG0505	Belongs to the CarA family
RG45_RS22265	COG1047	Peptidyl-prolyl cis-trans
RG45_RS22280	COG0196	riboflavin kinase activity
RG45_RS22300	COG3188	usher protein
RG45_RS22310	COG0583	DNA-binding transcription factor activity
RG45_RS22320	COG2963	transposase activity
RG45_RS22325	COG2801	Transposase and inactivated derivatives
RG45_RS22335	COG3385	transposase activity
RG45_RS22360	COG4735	regulation of single-species biofilm formation
RG45_RS22365	COG1584	GPR1 FUN34 yaaH family protein
RG45_RS22370	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG45_RS22375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG45_RS22380	COG1115	amino acid carrier protein
RG45_RS22400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RG45_RS22410	COG0527	aspartate kinase activity
RG45_RS22410	COG0460	homoserine dehydrogenase
RG45_RS22420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RG45_RS22430	COG0745	RESPONSE REGULATOR receiver
RG45_RS22435	COG4452	Inner membrane protein CreD
RG45_RS22440	COG2205	protein histidine kinase activity
RG45_RS22445	COG0745	RESPONSE REGULATOR receiver
RG45_RS22450	COG3045	CreA protein
RG45_RS22455	COG2207	Transcriptional regulator
RG45_RS22455	COG3708	Transcriptional regulator
RG45_RS22475	COG0741	lytic transglycosylase activity
RG45_RS22485	COG0488	(ABC) transporter
RG45_RS22495	COG3172	ATPase kinase involved in NAD metabolism
RG45_RS22495	COG1056	cytidyltransferase-related domain
RG45_RS22500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RG45_RS22505	COG0560	Phosphoserine phosphatase
RG45_RS22510	COG3726	membrane protein affecting hemolysin expression
RG45_RS22550	COG1328	CTP reductase activity
RG45_RS22555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG45_RS22565	COG0084	hydrolase, TatD family'
RG45_RS22570	COG4667	esterase of the alpha-beta hydrolase superfamily
RG45_RS22580	COG2823	Periplasmic or secreted lipoprotein
RG45_RS22590	COG1011	Hydrolase
RG45_RS22595	COG0456	acetyltransferase
RG45_RS22600	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
RG45_RS22635	COG4114	ferric iron reductase
RG45_RS22640	COG2197	response regulator
RG45_RS22645	COG2197	response regulator
RG45_RS22650	COG2966	Psort location CytoplasmicMembrane, score
RG45_RS22665	COG1484	DNA-dependent DNA replication
RG45_RS22680	COG1063	alcohol dehydrogenase
RG45_RS22685	COG1802	Transcriptional regulator
RG45_RS22690	COG2271	Major facilitator Superfamily
RG45_RS22695	COG0840	transmembrane signaling receptor activity
RG45_RS22700	COG1966	Carbon starvation protein
RG45_RS22705	COG2879	small protein
RG45_RS22710	COG0523	cobalamin synthesis protein
RG45_RS22745	COG2814	Major facilitator Superfamily
RG45_RS22750	COG2733	membrane
RG45_RS22755	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RG45_RS22760	COG1924	4 iron, 4 sulfur cluster binding
RG45_RS22775	COG0477	Major facilitator Superfamily
RG45_RS22785	COG3366	ferrous iron transmembrane transporter activity
RG45_RS22790	COG0700	Nucleoside recognition
RG45_RS22795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG45_RS22800	COG0583	DNA-binding transcription factor activity
RG45_RS22820	COG2186	Transcriptional regulator
RG45_RS22830	COG0246	Mannitol dehydrogenase
RG45_RS22845	COG2610	gluconate transmembrane transporter activity
RG45_RS22850	COG3539	Fimbrial protein
RG45_RS22855	COG3539	Fimbrial protein
RG45_RS22860	COG3539	Fimbrial protein
RG45_RS22885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG45_RS22910	COG0604	alcohol dehydrogenase
RG45_RS22930	COG3436	PFAM IS66 Orf2 family protein
RG45_RS22935	COG4372	Transposase
RG45_RS22940	COG0440	acetolactate synthase activity
RG45_RS22945	COG0440	acetolactate synthase activity
RG45_RS22950	COG1349	DNA-binding transcription factor activity
RG45_RS22960	COG0738	Major facilitator superfamily
RG45_RS22980	COG3037	sugar-specific permease SgaT UlaA
RG45_RS22990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG45_RS23010	COG4372	Transposase
RG45_RS23015	COG3547	Transposase (IS116 IS110 IS902 family)
RG45_RS23020	COG4372	Transposase
RG45_RS23025	COG3436	PFAM IS66 Orf2 family protein
RG45_RS23040	COG0582	viral genome integration into host DNA
RG45_RS23050	COG1064	alcohol dehydrogenase
RG45_RS23055	COG0433	COG0433 Predicted ATPase
RG45_RS23060	COG0795	lipopolysaccharide-transporting ATPase activity
RG45_RS23065	COG0795	lipopolysaccharide-transporting ATPase activity
RG45_RS23075	COG2927	DNA polymerase III (CHI subunit)
RG45_RS23080	COG0525	valine-tRNA ligase activity
RG45_RS23085	COG4269	membrane
RG45_RS23090	COG0456	acetyltransferase
RG45_RS23095	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
RG45_RS23110	COG2731	YhcH YjgK YiaL family protein
RG45_RS23115	COG1309	transcriptional regulator
RG45_RS23120	COG1028	Short-chain dehydrogenase reductase Sdr
RG45_RS23125	COG0251	oxidation-reduction process
RG45_RS23150	COG0251	oxidation-reduction process
RG45_RS23155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RG45_RS23160	COG1609	Transcriptional regulator
RG45_RS23165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG45_RS23165	COG1263	PTS System
RG45_RS23170	COG0366	Alpha amylase catalytic
RG45_RS23175	COG1328	CTP reductase activity
RG45_RS23180	COG0602	queuosine metabolic process
RG45_RS23185	COG3783	Cytochrome b(562)
RG45_RS23190	COG0312	modulator of DNA gyrase
RG45_RS23200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RG45_RS23210	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG45_RS23215	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG45_RS23225	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS23230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RG45_RS23235	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG45_RS23240	COG2336	PFAM SpoVT AbrB
RG45_RS23245	COG2105	PFAM AIG2 family protein
RG45_RS23250	COG2911	Protein conserved in bacteria
RG45_RS23255	COG0729	surface antigen
RG45_RS23270	COG1253	flavin adenine dinucleotide binding
RG45_RS23280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG45_RS23285	COG1218	3'(2'),5'-bisphosphate nucleotidase
RG45_RS23295	COG1733	regulation of RNA biosynthetic process
RG45_RS23300	COG0702	epimerase
RG45_RS23305	COG0697	spore germination
RG45_RS23315	COG1113	amino acid transport
RG45_RS23320	COG0545	Peptidyl-prolyl cis-trans isomerase
RG45_RS23330	COG3061	Opacity-associated protein A
RG45_RS23335	COG1309	transcriptional regulator
RG45_RS23350	COG1024	Enoyl-CoA hydratase
RG45_RS23355	COG4670	ketone body catabolic process
RG45_RS23360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG45_RS23365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG45_RS23380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG45_RS23390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RG45_RS23435	COG3414	Phosphotransferase system galactitol-specific IIB component
RG45_RS23440	COG3037	sugar-specific permease SgaT UlaA
RG45_RS23455	COG1073	alpha beta
RG45_RS23460	COG3650	response to hydrogen peroxide
RG45_RS23475	COG1960	acyl-CoA dehydrogenase activity
RG45_RS23480	COG0754	glutathionylspermidine amidase activity
RG45_RS23485	COG5463	Belongs to the UPF0441 family
RG45_RS23490	COG3766	membrane
RG45_RS23500	COG1842	Phage shock protein A
RG45_RS23505	COG3789	protein conserved in bacteria
RG45_RS23510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG45_RS23515	COG0557	exoribonuclease II activity
RG45_RS23530	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RG45_RS23535	COG0330	HflC and HflK could
RG45_RS23540	COG0330	HflC and HflK could
RG45_RS23545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RG45_RS23565	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG45_RS23570	COG0802	atpase or kinase
RG45_RS23575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RG45_RS23575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RG45_RS23580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG45_RS23615	COG3264	Mechanosensitive ion channel
RG45_RS23615	COG1511	domain protein
RG45_RS23630	COG0531	amino acid
RG45_RS23640	COG1053	succinate dehydrogenase
RG45_RS23645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG45_RS23660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG45_RS23665	COG3040	lipid binding
RG45_RS23670	COG2076	Multidrug Resistance protein
RG45_RS23675	COG5510	response to toxic substance
RG45_RS23680	COG5510	response to toxic substance
RG45_RS23690	COG1509	lysine 2,3-aminomutase activity
RG45_RS23715	COG0531	amino acid
RG45_RS23720	COG3030	protein affecting phage T7 exclusion by the F plasmid
RG45_RS23730	COG1027	Aspartate ammonia-lyase
RG45_RS23735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG45_RS23745	COG4232	protein-disulfide reductase activity
RG45_RS23750	COG1309	transcriptional regulator
RG45_RS23765	COG3710	Transcriptional regulator
RG45_RS23770	COG0531	amino acid
RG45_RS23775	COG1982	Orn Lys Arg decarboxylase major
RG45_RS23780	COG3104	oligopeptide transport
RG45_RS23785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG45_RS23820	COG2388	GCN5-related N-acetyl-transferase
RG45_RS23825	COG3592	Divergent 4Fe-4S mono-cluster
RG45_RS23830	COG3290	protein histidine kinase activity
RG45_RS23835	COG4565	transcriptional regulatory protein
RG45_RS23845	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG45_RS23850	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG45_RS23850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG45_RS23855	COG3647	Membrane
RG45_RS23860	COG2211	Major facilitator Superfamily
RG45_RS23865	COG1486	melibiose metabolic process
RG45_RS23875	COG2169	Transcriptional regulator
RG45_RS23880	COG1982	Orn Lys Arg decarboxylase major
RG45_RS23885	COG2207	Transcriptional regulator
RG45_RS23890	COG0531	amino acid
RG45_RS23895	COG2194	sulfuric ester hydrolase activity
RG45_RS23900	COG0745	RESPONSE REGULATOR receiver
RG45_RS23905	COG0642	Histidine kinase
RG45_RS23915	COG0477	Major facilitator Superfamily
RG45_RS23935	COG2824	Alkylphosphonate utilization operon protein PhnA
RG45_RS23950	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RG45_RS23960	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RG45_RS23965	COG3639	organic phosphonate transmembrane transporter activity
RG45_RS23970	COG2188	Transcriptional regulator
RG45_RS23975	COG3624	Phosphonate C-P lyase system protein PhnG
RG45_RS23980	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RG45_RS23985	COG3626	phosphonate metabolism
RG45_RS23990	COG3627	carbon phosphorus lyase activity
RG45_RS23995	COG4107	phosphonate C-P lyase system protein PhnK
RG45_RS24005	COG4778	phosphonate C-P lyase system protein PhnL
RG45_RS24010	COG3454	Phosphonate metabolism
RG45_RS24015	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RG45_RS24020	COG0456	acetyltransferase
RG45_RS24025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RG45_RS24035	COG0698	ribose 5-phosphate isomerase
RG45_RS24045	COG1737	Transcriptional regulator
RG45_RS24050	COG1879	ABC-type sugar transport system periplasmic component
RG45_RS24055	COG1129	ABC transporter
RG45_RS24060	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG45_RS24065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG45_RS24070	COG1940	carbohydrate kinase activity
RG45_RS24075	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RG45_RS24085	COG1566	PFAM secretion protein HlyD family protein
RG45_RS24090	COG1289	transmembrane transporter activity
RG45_RS24095	COG1538	Outer membrane efflux protein
RG45_RS24100	COG3383	formate dehydrogenase (NAD+) activity
RG45_RS24105	COG3383	formate dehydrogenase (NAD+) activity
RG45_RS24110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG45_RS24115	COG1301	dicarboxylic acid transport
RG45_RS24125	COG4235	cytochrome complex assembly
RG45_RS24130	COG3088	subunit of a heme lyase
RG45_RS24135	COG1138	Cytochrome C-type biogenesis protein
RG45_RS24140	COG3301	Polysulphide reductase, NrfD
RG45_RS24145	COG0437	4 iron, 4 sulfur cluster binding
RG45_RS24150	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RG45_RS24165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG45_RS24170	COG3162	membrane
RG45_RS24180	COG1357	PFAM Pentapeptide repeats (8 copies)
RG45_RS24185	COG0025	NhaP-type Na H and K H
RG45_RS24190	COG2252	PERMEase
RG45_RS24210	COG0789	Transcriptional regulator
RG45_RS24215	COG2207	Transcriptional regulator
RG45_RS24220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG45_RS24235	COG0629	single-stranded DNA binding
RG45_RS24240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RG45_RS24245	COG2315	Protein conserved in bacteria
RG45_RS24250	COG0432	Pfam Uncharacterised protein family UPF0047
RG45_RS24255	COG3700	Belongs to the class B bacterial acid phosphatase family
RG45_RS24280	COG1448	Aminotransferase
RG45_RS24285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG45_RS24290	COG0305	Participates in initiation and elongation during chromosome replication
RG45_RS24295	COG0604	alcohol dehydrogenase
RG45_RS24305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG45_RS24320	COG0735	belongs to the Fur family
RG45_RS24325	COG3237	CsbD-like
RG45_RS24330	COG0534	Mate efflux family protein
RG45_RS24340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RG45_RS24370	COG1357	PFAM Pentapeptide repeats (8 copies)
RG45_RS24405	COG3842	ATPase activity
RG45_RS24415	COG2182	Extracellular solute-binding protein
RG45_RS24420	COG1175	transmembrane transport
RG45_RS24425	COG3833	ABC-type maltose transport systems, permease component
RG45_RS24430	COG0477	Major facilitator Superfamily
RG45_RS24430	COG2814	Major facilitator Superfamily
RG45_RS24450	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG45_RS24505	COG0527	aspartate kinase activity
RG45_RS24515	COG1187	pseudouridine synthase activity
RG45_RS24525	COG1283	sodium-dependent phosphate transmembrane transporter activity
RG45_RS24530	COG0646	methionine synthase
RG45_RS24530	COG1410	methionine synthase
RG45_RS24535	COG1414	Transcriptional regulator
RG45_RS24580	COG2224	Isocitrate lyase
RG45_RS24585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG45_RS24595	COG0456	acetyltransferase
RG45_RS24635	COG0151	Belongs to the GarS family
RG45_RS24640	COG2204	response regulator
RG45_RS24645	COG4191	Histidine kinase
RG45_RS24655	COG3678	ATP-independent chaperone mediated protein folding
RG45_RS24670	COG3068	Protein conserved in bacteria
RG45_RS24705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG45_RS24710	COG2104	thiamine diphosphate biosynthetic process
RG45_RS24720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RG45_RS24760	COG0250	Participates in transcription elongation, termination and antitermination
RG45_RS24765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG45_RS24810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RG45_RS24810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RG45_RS25025	COG1882	Formate acetyltransferase
RG45_RS25155	COG4206	TonB-dependent receptor
RG45_RS25220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde