locus-tag	class	description
RG48_RS00005	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
RG48_RS00010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG48_RS00015	COG1739	Uncharacterized protein family UPF0029
RG48_RS00030	COG0183	Belongs to the thiolase family
RG48_RS00040	COG0543	2 iron, 2 sulfur cluster binding
RG48_RS00045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RG48_RS00050	COG0250	Participates in transcription elongation, termination and antitermination
RG48_RS00055	COG0084	hydrolase, TatD family'
RG48_RS00060	COG0805	protein transport
RG48_RS00065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG48_RS00070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG48_RS00080	COG3165	ubiquinone biosynthetic process from chorismate
RG48_RS00090	COG1322	Protein conserved in bacteria
RG48_RS00100	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RG48_RS00105	COG0412	Dienelactone hydrolase
RG48_RS00115	COG0583	DNA-binding transcription factor activity
RG48_RS00120	COG0697	spore germination
RG48_RS00125	COG0561	phosphatase activity
RG48_RS00130	COG2267	carboxylic ester hydrolase activity
RG48_RS00135	COG1280	lysine exporter protein (LysE YggA)
RG48_RS00140	COG1280	lysine exporter protein (LysE YggA)
RG48_RS00145	COG0514	ATP-dependent DNA helicase (RecQ)
RG48_RS00150	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RG48_RS00155	COG2050	protein possibly involved in aromatic compounds catabolism
RG48_RS00160	COG2962	Rard protein
RG48_RS00175	COG0598	Magnesium transport protein CorA
RG48_RS00185	COG3698	Phosphodiester glycosidase
RG48_RS00190	COG0210	DNA helicase
RG48_RS00195	COG1011	Hydrolase
RG48_RS00205	COG3159	Protein conserved in bacteria
RG48_RS00215	COG5567	small periplasmic lipoprotein
RG48_RS00230	COG3072	Adenylate cyclase
RG48_RS00245	COG1587	Uroporphyrinogen-III synthase
RG48_RS00250	COG2959	enzyme of heme biosynthesis
RG48_RS00255	COG3071	HemY protein
RG48_RS00260	COG3119	arylsulfatase activity
RG48_RS00290	COG1113	amino acid transport
RG48_RS00310	COG2244	polysaccharide biosynthetic process
RG48_RS00315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RG48_RS00320	COG0456	acetyltransferase
RG48_RS00325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG48_RS00330	COG1088	dTDP-glucose 4,6-dehydratase activity
RG48_RS00335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RG48_RS00340	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RG48_RS00345	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG48_RS00350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RG48_RS00360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RG48_RS00370	COG3118	belongs to the thioredoxin family
RG48_RS00390	COG0210	DNA helicase
RG48_RS00395	COG3692	DNA binding
RG48_RS00400	COG3692	DNA binding
RG48_RS00405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG48_RS00415	COG0583	DNA-binding transcription factor activity
RG48_RS00420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG48_RS00430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG48_RS00435	COG3978	acetolactate synthase activity
RG48_RS00450	COG0606	chelatase, subunit chli
RG48_RS00455	COG3085	chromosome segregation
RG48_RS00495	COG2186	Transcriptional regulator
RG48_RS00500	COG0477	Major facilitator Superfamily
RG48_RS00505	COG1609	Transcriptional regulator
RG48_RS00510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS00515	COG1879	ABC-type sugar transport system periplasmic component
RG48_RS00520	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG48_RS00525	COG1129	ABC transporter
RG48_RS00555	COG1522	sequence-specific DNA binding
RG48_RS00560	COG0716	FMN binding
RG48_RS00575	COG3312	ion transport
RG48_RS00635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG48_RS00640	COG0573	inorganic phosphate transmembrane transporter activity
RG48_RS00645	COG0581	inorganic phosphate transmembrane transporter activity
RG48_RS00650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RG48_RS00655	COG0704	Plays a role in the regulation of phosphate uptake
RG48_RS00660	COG3711	transcriptional antiterminator
RG48_RS00665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS00665	COG2190	(PTS) system
RG48_RS00665	COG1263	PTS System
RG48_RS00670	COG2723	6-phospho-beta-galactosidase activity
RG48_RS00680	COG2382	esterase
RG48_RS00685	COG0363	glucosamine-6-phosphate deaminase activity
RG48_RS00690	COG3196	Protein conserved in bacteria
RG48_RS00700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG48_RS00705	COG2252	PERMEase
RG48_RS00710	COG0431	NADPH-dependent FMN reductase
RG48_RS00715	COG2091	lysine biosynthetic process via aminoadipic acid
RG48_RS00730	COG0814	amino acid
RG48_RS00780	COG0592	DNA-directed DNA polymerase activity
RG48_RS00790	COG0187	DNA topoisomerase II activity
RG48_RS00795	COG3753	Protein conserved in bacteria
RG48_RS00800	COG0561	phosphatase activity
RG48_RS00810	COG2186	Transcriptional regulator
RG48_RS00815	COG3734	2-keto-3-deoxy-galactonokinase
RG48_RS00820	COG0800	Aldolase
RG48_RS00830	COG2271	Major facilitator Superfamily
RG48_RS00835	COG0644	oxidoreductase
RG48_RS00840	COG0823	Involved in the tonB-independent uptake of proteins
RG48_RS00845	COG5645	(Lipo)protein
RG48_RS00885	COG2207	Transcriptional regulator
RG48_RS00890	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG48_RS00895	COG3119	arylsulfatase activity
RG48_RS00905	COG2149	membrane
RG48_RS00915	COG0641	radical SAM
RG48_RS00920	COG2814	Major facilitator Superfamily
RG48_RS00955	COG0028	Belongs to the TPP enzyme family
RG48_RS00960	COG0440	acetolactate synthase activity
RG48_RS00965	COG2197	response regulator
RG48_RS00970	COG3851	Histidine kinase
RG48_RS00975	COG2271	Major facilitator Superfamily
RG48_RS00980	COG2271	Major facilitator Superfamily
RG48_RS00990	COG2252	PERMEase
RG48_RS01025	COG1464	Belongs to the NlpA lipoprotein family
RG48_RS01030	COG0697	spore germination
RG48_RS01035	COG2814	Major facilitator Superfamily
RG48_RS01060	COG2003	Belongs to the UPF0758 family
RG48_RS01080	COG2378	regulation of single-species biofilm formation
RG48_RS01090	COG2378	regulation of single-species biofilm formation
RG48_RS01100	COG3596	GTP binding
RG48_RS01120	COG2801	Transposase and inactivated derivatives
RG48_RS01130	COG3328	transposase activity
RG48_RS01160	COG0071	Belongs to the small heat shock protein (HSP20) family
RG48_RS01165	COG0542	response to heat
RG48_RS01175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG48_RS01225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG48_RS01230	COG3039	Transposase
RG48_RS01235	COG2801	Transposase and inactivated derivatives
RG48_RS01245	COG2963	transposase activity
RG48_RS01260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RG48_RS01280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RG48_RS01290	COG0582	viral genome integration into host DNA
RG48_RS01300	COG2211	Major facilitator Superfamily
RG48_RS01305	COG1501	Belongs to the glycosyl hydrolase 31 family
RG48_RS01310	COG2982	Protein involved in outer membrane biogenesis
RG48_RS01315	COG2233	PERMEase
RG48_RS01320	COG0786	glutamate:sodium symporter activity
RG48_RS01325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RG48_RS01330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG48_RS01335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG48_RS01345	COG0194	GDP metabolic process
RG48_RS01355	COG2860	membrane
RG48_RS01365	COG1561	YicC-like family, N-terminal region
RG48_RS01395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RG48_RS01425	COG1519	Transferase
RG48_RS01430	COG0859	PFAM glycosyl transferase family 9
RG48_RS01435	COG0438	transferase activity, transferring glycosyl groups
RG48_RS01440	COG0515	serine threonine protein kinase
RG48_RS01455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RG48_RS01460	COG1442	glycosyl transferase family 8
RG48_RS01465	COG1216	Glycosyl transferase, family 2
RG48_RS01470	COG3307	-O-antigen
RG48_RS01475	COG0859	PFAM glycosyl transferase family 9
RG48_RS01480	COG0859	PFAM glycosyl transferase family 9
RG48_RS01495	COG0156	8-amino-7-oxononanoate synthase activity
RG48_RS01505	COG1216	Glycosyl transferase, family 2
RG48_RS01510	COG2861	carbohydrate metabolic process
RG48_RS01515	COG4942	peptidase
RG48_RS01530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG48_RS01535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG48_RS01550	COG1045	serine acetyltransferase
RG48_RS01555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RG48_RS01565	COG2186	Transcriptional regulator
RG48_RS01570	COG1620	l-lactate permease
RG48_RS01575	COG5295	Hep Hag repeat protein
RG48_RS01600	COG3722	fumarate hydratase activity
RG48_RS01610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS01610	COG2213	PTS system mannitol-specific
RG48_RS01620	COG1566	PFAM secretion protein HlyD family protein
RG48_RS01645	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG48_RS01650	COG3209	COG3209 Rhs family protein
RG48_RS01655	COG1413	lyase activity
RG48_RS01660	COG3209	COG3209 Rhs family protein
RG48_RS01665	COG0625	glutathione transferase activity
RG48_RS01675	COG3276	selenocysteine insertion sequence binding
RG48_RS01680	COG1454	alcohol dehydrogenase
RG48_RS01685	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS01700	COG1566	PFAM secretion protein HlyD family protein
RG48_RS01705	COG0583	DNA-binding transcription factor activity
RG48_RS01710	COG3713	MltA-interacting MipA family protein
RG48_RS01715	COG0235	Class ii aldolase
RG48_RS01725	COG1070	Carbohydrate kinase
RG48_RS01730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG48_RS01735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RG48_RS01740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG48_RS01745	COG2731	YhcH YjgK YiaL family protein
RG48_RS01755	COG1414	Transcriptional regulator
RG48_RS01760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS01765	COG3977	Valine--pyruvate aminotransferase
RG48_RS01770	COG0366	Alpha amylase catalytic
RG48_RS01775	COG2992	FlgJ-related protein
RG48_RS01785	COG4214	carbohydrate transport
RG48_RS01790	COG1129	ABC transporter
RG48_RS01795	COG4213	ABC transporter substrate-binding protein
RG48_RS01805	COG1070	Carbohydrate kinase
RG48_RS01810	COG4682	membrane
RG48_RS01815	COG4682	membrane
RG48_RS01820	COG3274	enterobacterial common antigen metabolic process
RG48_RS01840	COG2963	transposase activity
RG48_RS01845	COG2801	Transposase and inactivated derivatives
RG48_RS01855	COG1278	Cold shock
RG48_RS01860	COG2944	sequence-specific DNA binding
RG48_RS01875	COG2885	chlorophyll binding
RG48_RS01880	COG0243	molybdopterin cofactor binding
RG48_RS01885	COG0456	acetyltransferase
RG48_RS01890	COG2818	Glycosylase
RG48_RS01895	COG5571	outer membrane autotransporter
RG48_RS01905	COG2223	nitrite transmembrane transporter activity
RG48_RS01910	COG2194	sulfuric ester hydrolase activity
RG48_RS01930	COG0747	negative chemotaxis
RG48_RS01940	COG0601	transmembrane transport
RG48_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG48_RS01950	COG0444	Belongs to the ABC transporter superfamily
RG48_RS01955	COG4608	Belongs to the ABC transporter superfamily
RG48_RS01960	COG0814	amino acid
RG48_RS01980	COG2194	sulfuric ester hydrolase activity
RG48_RS02005	COG1215	transferase activity, transferring glycosyl groups
RG48_RS02010	COG1215	transferase activity, transferring glycosyl groups
RG48_RS02015	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RG48_RS02020	COG0457	Tetratricopeptide repeat
RG48_RS02020	COG3118	belongs to the thioredoxin family
RG48_RS02025	COG2200	EAL domain
RG48_RS02025	COG2199	diguanylate cyclase activity
RG48_RS02045	COG0612	Peptidase, M16
RG48_RS02060	COG2200	EAL domain
RG48_RS02065	COG2982	Protein involved in outer membrane biogenesis
RG48_RS02070	COG0477	Major facilitator Superfamily
RG48_RS02075	COG1295	ribonuclease BN
RG48_RS02080	COG0583	DNA-binding transcription factor activity
RG48_RS02085	COG2197	response regulator
RG48_RS02095	COG1858	cytochrome C peroxidase
RG48_RS02100	COG0076	glutamate decarboxylase activity
RG48_RS02105	COG2207	Transcriptional regulator
RG48_RS02110	COG2207	Transcriptional regulator
RG48_RS02120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG48_RS02125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS02135	COG2771	luxR family
RG48_RS02140	COG3247	response to pH
RG48_RS02155	COG1285	pathogenesis
RG48_RS02160	COG2197	response regulator
RG48_RS02170	COG3065	identical protein binding
RG48_RS02180	COG1393	Belongs to the ArsC family
RG48_RS02185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG48_RS02190	COG0640	Transcriptional regulator
RG48_RS02205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG48_RS02210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RG48_RS02215	COG0339	signal peptide processing
RG48_RS02225	COG3104	oligopeptide transport
RG48_RS02235	COG0589	response to stress
RG48_RS02250	COG0306	phosphate transporter
RG48_RS02255	COG2081	HI0933 family
RG48_RS02285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS02290	COG0842	Transport permease protein
RG48_RS02290	COG1129	ABC transporter
RG48_RS02295	COG0842	Transport permease protein
RG48_RS02300	COG5433	transposase activity
RG48_RS02305	COG1413	lyase activity
RG48_RS02315	COG3209	COG3209 Rhs family protein
RG48_RS02325	COG1124	(ABC) transporter
RG48_RS02330	COG0444	Belongs to the ABC transporter superfamily
RG48_RS02335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG48_RS02340	COG0601	transmembrane transport
RG48_RS02345	COG0747	negative chemotaxis
RG48_RS02350	COG2091	lysine biosynthetic process via aminoadipic acid
RG48_RS02355	COG0628	permease
RG48_RS02360	COG0477	Major facilitator Superfamily
RG48_RS02370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RG48_RS02385	COG3714	YhhN family
RG48_RS02395	COG3776	membrane
RG48_RS02400	COG0742	ribosomal rna small subunit methyltransferase
RG48_RS02405	COG0552	protein localization to endoplasmic reticulum
RG48_RS02410	COG2884	Cell division ATP-binding protein ftsE
RG48_RS02415	COG2177	Part of the ABC transporter FtsEX involved in
RG48_RS02420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG48_RS02425	COG0683	leucine binding
RG48_RS02430	COG0456	acetyltransferase
RG48_RS02440	COG0683	leucine binding
RG48_RS02445	COG0559	Belongs to the binding-protein-dependent transport system permease family
RG48_RS02450	COG4177	L-phenylalanine transmembrane transporter activity
RG48_RS02455	COG0411	ABC transporter
RG48_RS02460	COG0410	ABC transporter
RG48_RS02470	COG1653	transport
RG48_RS02475	COG1175	transmembrane transport
RG48_RS02485	COG3842	ATPase activity
RG48_RS02490	COG0584	glycerophosphoryl diester phosphodiesterase
RG48_RS02500	COG0405	Gamma-glutamyltransferase
RG48_RS02520	COG3157	Type VI secretion system effector, Hcp
RG48_RS02525	COG1247	-acetyltransferase
RG48_RS02530	COG0673	inositol 2-dehydrogenase activity
RG48_RS02535	COG1741	Belongs to the pirin family
RG48_RS02540	COG1609	Transcriptional regulator
RG48_RS02545	COG3265	gluconokinase activity
RG48_RS02550	COG2610	gluconate transmembrane transporter activity
RG48_RS02555	COG2095	MarC family integral membrane protein
RG48_RS02560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG48_RS02585	COG0058	SHG alpha-glucan phosphorylase activity
RG48_RS02590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG48_RS02610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG48_RS02625	COG1349	DNA-binding transcription factor activity
RG48_RS02630	COG4650	regulator
RG48_RS02635	COG1690	Belongs to the RtcB family
RG48_RS02650	COG0058	SHG alpha-glucan phosphorylase activity
RG48_RS02655	COG1640	4-alpha-glucanotransferase
RG48_RS02660	COG2610	gluconate transmembrane transporter activity
RG48_RS02680	COG5464	transposase or invertase
RG48_RS02695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RG48_RS02700	COG1918	ferrous iron import across plasma membrane
RG48_RS02710	COG2183	response to ionizing radiation
RG48_RS02715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG48_RS02745	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG48_RS02755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RG48_RS02760	COG1011	Hydrolase
RG48_RS02770	COG0494	nUDIX hydrolase
RG48_RS02775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RG48_RS02780	COG4972	Pilus assembly protein
RG48_RS02785	COG3166	PFAM Fimbrial assembly family protein
RG48_RS02800	COG4796	Type ii and iii secretion system protein
RG48_RS02815	COG3266	domain, Protein
RG48_RS02820	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RG48_RS02825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG48_RS02830	COG0546	phosphoglycolate phosphatase activity
RG48_RS02835	COG0180	Tryptophanyl-tRNA synthetase
RG48_RS02845	COG2188	Transcriptional regulator
RG48_RS02855	COG3457	Alanine racemase
RG48_RS02860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RG48_RS02865	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RG48_RS02880	COG0626	cystathionine gamma-synthase activity
RG48_RS02885	COG2188	Transcriptional regulator
RG48_RS02890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS02895	COG1082	Xylose isomerase domain protein TIM barrel
RG48_RS02900	COG1082	Xylose isomerase domain protein TIM barrel
RG48_RS02905	COG2222	sugar isomerase
RG48_RS02910	COG0531	amino acid
RG48_RS02925	COG2116	formate transmembrane transporter activity
RG48_RS02930	COG2146	nitrite reductase [NAD(P)H] activity
RG48_RS02935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG48_RS02950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG48_RS02960	COG2184	nucleotidyltransferase activity
RG48_RS02965	COG0512	Glutamine amidotransferase of anthranilate synthase
RG48_RS02970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RG48_RS02975	COG1289	transmembrane transporter activity
RG48_RS02980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG48_RS02990	COG1765	OsmC-like protein
RG48_RS02995	COG3954	Phosphoribulokinase
RG48_RS03005	COG0429	hydrolase of the alpha beta-hydrolase fold
RG48_RS03010	COG0488	(ABC) transporter
RG48_RS03025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RG48_RS03030	COG1047	Peptidyl-prolyl cis-trans
RG48_RS03040	COG0545	Peptidyl-prolyl cis-trans isomerase
RG48_RS03045	COG2964	Protein conserved in bacteria
RG48_RS03085	COG3979	chitinase
RG48_RS03090	COG2906	2 iron, 2 sulfur cluster binding
RG48_RS03095	COG2193	ferroxidase activity
RG48_RS03100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RG48_RS03105	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG48_RS03110	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG48_RS03115	COG3156	type II secretion system protein K
RG48_RS03120	COG4795	General secretion pathway protein
RG48_RS03125	COG2165	general secretion pathway protein
RG48_RS03130	COG2165	general secretion pathway protein
RG48_RS03140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG48_RS03145	COG1450	Type ii and iii secretion system protein
RG48_RS03150	COG3031	protein transport across the cell outer membrane
RG48_RS03155	COG3267	Type II secretory pathway component ExeA
RG48_RS03155	COG3409	Peptidoglycan-binding domain 1 protein
RG48_RS03180	COG0089	rRNA binding
RG48_RS03270	COG0201	protein transport
RG48_RS03310	COG0789	Transcriptional regulator
RG48_RS03315	COG3036	rescue of stalled ribosome
RG48_RS03325	COG0569	domain protein
RG48_RS03345	COG0758	DNA mediated transformation
RG48_RS03355	COG0551	DNA topoisomerase type I activity
RG48_RS03375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG48_RS03410	COG1126	abc transporter atp-binding protein
RG48_RS03415	COG0765	amino acid transport
RG48_RS03420	COG4597	amino acid ABC transporter
RG48_RS03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS03435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG48_RS03440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS03450	COG1309	transcriptional regulator
RG48_RS03460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RG48_RS03470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG48_RS03480	COG4145	pantothenate transmembrane transporter activity
RG48_RS03485	COG3924	membrane
RG48_RS03490	COG0439	Biotin carboxylase
RG48_RS03495	COG0511	ligase activity, forming carbon-carbon bonds
RG48_RS03510	COG0604	alcohol dehydrogenase
RG48_RS03515	COG2200	EAL domain
RG48_RS03515	COG2199	diguanylate cyclase activity
RG48_RS03530	COG1077	Cell shape determining protein MreB Mrl
RG48_RS03535	COG1792	Involved in formation and maintenance of cell shape
RG48_RS03540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RG48_RS03550	COG1530	ribonuclease E activity
RG48_RS03555	COG3164	Protein of unknown function
RG48_RS03570	COG0312	modulator of DNA gyrase
RG48_RS03575	COG0583	DNA-binding transcription factor activity
RG48_RS03595	COG2732	(Barnase) inhibitor
RG48_RS03615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG48_RS03620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG48_RS03625	COG3105	Protein conserved in bacteria
RG48_RS03630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RG48_RS03645	COG0625	glutathione transferase activity
RG48_RS03650	COG2969	positive regulation of protein catabolic process
RG48_RS03655	COG3069	C4-dicarboxylate transmembrane transporter activity
RG48_RS03685	COG2731	YhcH YjgK YiaL family protein
RG48_RS03695	COG4804	nuclease activity
RG48_RS03700	COG0493	'glutamate synthase
RG48_RS03705	COG0067	glutamate synthase
RG48_RS03705	COG0070	glutamate synthase
RG48_RS03705	COG0069	glutamate synthase activity
RG48_RS03720	COG1242	4 iron, 4 sulfur cluster binding
RG48_RS03725	COG5002	protein histidine kinase activity
RG48_RS03725	COG0784	Response regulator, receiver
RG48_RS03725	COG2198	Histidine kinase
RG48_RS03730	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RG48_RS03740	COG0515	serine threonine protein kinase
RG48_RS03745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS03760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG48_RS03765	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RG48_RS03770	COG1137	ATPase activity
RG48_RS03775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RG48_RS03780	COG3117	lipopolysaccharide transmembrane transporter activity
RG48_RS03785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RG48_RS03790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG48_RS03790	COG0517	IMP dehydrogenase activity
RG48_RS03795	COG0530	calcium, potassium:sodium antiporter activity
RG48_RS03800	COG1127	ABC transporter
RG48_RS03805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RG48_RS03810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG48_RS03815	COG2854	intermembrane phospholipid transfer
RG48_RS03820	COG3113	response to antibiotic
RG48_RS03825	COG5007	Belongs to the BolA IbaG family
RG48_RS03835	COG3423	Transcriptional regulator
RG48_RS03840	COG0142	geranyltranstransferase activity
RG48_RS03855	COG0697	spore germination
RG48_RS03865	COG2027	D-alanyl-D-alanine carboxypeptidase
RG48_RS03870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG48_RS03875	COG1534	Rna-binding protein
RG48_RS03885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG48_RS03890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RG48_RS03900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG48_RS03935	COG0195	Participates in both transcription termination and antitermination
RG48_RS03975	COG0513	Belongs to the DEAD box helicase family
RG48_RS03985	COG0814	amino acid
RG48_RS03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RG48_RS03995	COG0826	peptidase U32
RG48_RS04000	COG0826	peptidase U32
RG48_RS04005	COG3154	lipid carrier protein
RG48_RS04010	COG3153	acetyltransferase
RG48_RS04025	COG0693	protein deglycase activity
RG48_RS04030	COG0702	epimerase
RG48_RS04035	COG0701	Predicted permease
RG48_RS04040	COG2823	Periplasmic or secreted lipoprotein
RG48_RS04055	COG3107	peptidoglycan biosynthetic process
RG48_RS04060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RG48_RS04065	COG3539	Fimbrial protein
RG48_RS04070	COG3188	usher protein
RG48_RS04075	COG3121	Chaperone
RG48_RS04080	COG3539	Fimbrial protein
RG48_RS04085	COG0363	glucosamine-6-phosphate deaminase activity
RG48_RS04090	COG3716	PTS system mannose fructose sorbose family IID component
RG48_RS04095	COG3715	PTS system
RG48_RS04100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS04110	COG2222	sugar isomerase
RG48_RS04115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG48_RS04120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS04125	COG3716	PTS system mannose fructose sorbose family IID component
RG48_RS04135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS04150	COG1349	DNA-binding transcription factor activity
RG48_RS04160	COG2002	toxin-antitoxin pair type II binding
RG48_RS04165	COG2721	sulfolactate sulfo-lyase activity
RG48_RS04170	COG2271	Major facilitator Superfamily
RG48_RS04180	COG2084	Dehydrogenase
RG48_RS04185	COG1929	Belongs to the glycerate kinase type-1 family
RG48_RS04215	COG0583	DNA-binding transcription factor activity
RG48_RS04220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG48_RS04230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG48_RS04235	COG1882	Formate acetyltransferase
RG48_RS04240	COG0251	oxidation-reduction process
RG48_RS04245	COG1760	l-serine dehydratase
RG48_RS04250	COG0814	amino acid
RG48_RS04265	COG1741	Belongs to the pirin family
RG48_RS04270	COG0583	DNA-binding transcription factor activity
RG48_RS04280	COG3152	Membrane
RG48_RS04285	COG3152	Membrane
RG48_RS04290	COG0435	Glutathione S-transferase
RG48_RS04295	COG2259	Doxx family
RG48_RS04305	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
RG48_RS04310	COG4575	ribosome binding
RG48_RS04315	COG1422	Protein of unknown function (DUF1090)
RG48_RS04325	COG0586	Pfam SNARE associated Golgi protein
RG48_RS04330	COG2186	Transcriptional regulator
RG48_RS04355	COG2271	Major facilitator Superfamily
RG48_RS04365	COG2721	sulfolactate sulfo-lyase activity
RG48_RS04375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RG48_RS04380	COG0861	Integral membrane protein TerC family
RG48_RS04385	COG0673	inositol 2-dehydrogenase activity
RG48_RS04390	COG2949	membrane
RG48_RS04395	COG1451	nucleotide metabolic process
RG48_RS04410	COG4680	protein conserved in bacteria
RG48_RS04415	COG5499	transcription regulator containing HTH domain
RG48_RS04420	COG0446	pyridine nucleotide-disulphide oxidoreductase
RG48_RS04420	COG1902	pentaerythritol trinitrate reductase activity
RG48_RS04425	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RG48_RS04425	COG3408	Glycogen debranching enzyme
RG48_RS04435	COG0531	amino acid
RG48_RS04440	COG2731	YhcH YjgK YiaL family protein
RG48_RS04445	COG3250	beta-galactosidase activity
RG48_RS04450	COG1609	Transcriptional regulator
RG48_RS04460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG48_RS04475	COG0840	transmembrane signaling receptor activity
RG48_RS04480	COG1695	Transcriptional regulator
RG48_RS04490	COG2375	cellular response to nickel ion
RG48_RS04505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG48_RS04515	COG0358	DNA primase activity
RG48_RS04520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RG48_RS04535	COG0471	metal ion transport
RG48_RS04540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG48_RS04545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG48_RS04555	COG0583	DNA-binding transcription factor activity
RG48_RS04565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG48_RS04580	COG4991	sh3 domain protein
RG48_RS04590	COG3025	triphosphatase activity
RG48_RS04615	COG2268	Band 7 protein
RG48_RS04620	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG48_RS04630	COG3539	Fimbrial protein
RG48_RS04635	COG3121	Chaperone
RG48_RS04640	COG3188	usher protein
RG48_RS04645	COG3539	Fimbrial protein
RG48_RS04650	COG2960	long-chain fatty acid transporting porin activity
RG48_RS04670	COG3384	dioxygenase
RG48_RS04675	COG0754	glutathionylspermidine amidase activity
RG48_RS04690	COG1538	Outer membrane efflux protein
RG48_RS04695	COG0494	nUDIX hydrolase
RG48_RS04700	COG3151	Protein conserved in bacteria
RG48_RS04705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RG48_RS04710	COG3150	esterase
RG48_RS04715	COG0187	DNA topoisomerase II activity
RG48_RS04720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RG48_RS04725	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG48_RS04735	COG0642	Histidine kinase
RG48_RS04740	COG0745	RESPONSE REGULATOR receiver
RG48_RS04745	COG3111	PFAM Bacterial OB fold (BOF) protein
RG48_RS04750	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG48_RS04760	COG2944	sequence-specific DNA binding
RG48_RS04765	COG4166	transmembrane transport
RG48_RS04770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG48_RS04780	COG0204	Acyl-transferase
RG48_RS04785	COG2132	Multicopper oxidase
RG48_RS04790	COG1032	radical SAM domain protein
RG48_RS04795	COG4238	major outer membrane lipoprotein
RG48_RS04805	COG0656	L-ascorbic acid biosynthetic process
RG48_RS04810	COG1979	alcohol dehydrogenase
RG48_RS04820	COG2207	Transcriptional regulator
RG48_RS04825	COG0586	Pfam SNARE associated Golgi protein
RG48_RS04830	COG0626	cystathionine gamma-synthase activity
RG48_RS04840	COG0811	peptide transport
RG48_RS04845	COG0848	biopolymer transport protein
RG48_RS04865	COG0667	Aldo Keto reductase
RG48_RS04885	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG48_RS04890	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS04895	COG5557	Pfam Polysulphide reductase, NrfD
RG48_RS04900	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG48_RS04905	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG48_RS04910	COG1773	rubredoxin
RG48_RS04920	COG0298	carbon dioxide binding
RG48_RS04925	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS04935	COG0625	glutathione transferase activity
RG48_RS04940	COG0754	glutathionylspermidine amidase activity
RG48_RS04945	COG0306	phosphate transporter
RG48_RS04950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG48_RS04955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG48_RS04965	COG2244	polysaccharide biosynthetic process
RG48_RS04975	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG48_RS04980	COG0795	lipopolysaccharide-transporting ATPase activity
RG48_RS04990	COG0156	8-amino-7-oxononanoate synthase activity
RG48_RS04995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RG48_RS05005	COG0318	PFAM AMP-dependent synthetase and ligase
RG48_RS05015	COG0456	acetyltransferase
RG48_RS05020	COG2186	Transcriptional regulator
RG48_RS05025	COG0277	FAD linked oxidase domain protein
RG48_RS05030	COG0277	FAD linked oxidase domain protein
RG48_RS05035	COG0247	lactate metabolic process
RG48_RS05040	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RG48_RS05045	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG48_RS05050	COG1620	l-lactate permease
RG48_RS05065	COG3064	Membrane
RG48_RS05070	COG2165	general secretion pathway protein
RG48_RS05090	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG48_RS05100	COG1811	Na channel or pump
RG48_RS05110	COG1982	Orn Lys Arg decarboxylase major
RG48_RS05115	COG2211	Major facilitator Superfamily
RG48_RS05130	COG1194	a g-specific adenine glycosylase
RG48_RS05145	COG3171	Protein conserved in bacteria
RG48_RS05155	COG0252	asparaginase activity
RG48_RS05165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG48_RS05170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RG48_RS05180	COG0762	integral membrane protein
RG48_RS05185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RG48_RS05190	COG2805	Type II/IV secretion system protein
RG48_RS05205	COG0189	ligase activity
RG48_RS05210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RG48_RS05215	COG2356	endonuclease I
RG48_RS05225	COG2814	Major facilitator Superfamily
RG48_RS05255	COG1166	arginine decarboxylase activity
RG48_RS05265	COG0501	Belongs to the peptidase M48B family
RG48_RS05270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG48_RS05275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS05280	COG2213	PTS system mannitol-specific
RG48_RS05285	COG1063	alcohol dehydrogenase
RG48_RS05290	COG1494	fructose-1,6-bisphosphatase
RG48_RS05295	COG3722	fumarate hydratase activity
RG48_RS05300	COG1072	(Pantothenic acid kinase))
RG48_RS05320	COG0191	fructose-bisphosphate aldolase activity
RG48_RS05325	COG0668	transmembrane transport
RG48_RS05330	COG1279	arginine transmembrane transporter activity
RG48_RS05335	COG2968	Membrane
RG48_RS05340	COG0583	DNA-binding transcription factor activity
RG48_RS05345	COG0427	acetyl-CoA hydrolase
RG48_RS05350	COG1024	Enoyl-CoA hydratase
RG48_RS05355	COG1703	isobutyryl-CoA mutase activity
RG48_RS05360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG48_RS05360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG48_RS05385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RG48_RS05395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RG48_RS05420	COG0006	proline dipeptidase activity
RG48_RS05425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG48_RS05430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG48_RS05450	COG2723	6-phospho-beta-galactosidase activity
RG48_RS05460	COG1272	protein, Hemolysin III
RG48_RS05470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RG48_RS05480	COG0716	FMN binding
RG48_RS05485	COG4974	Belongs to the 'phage' integrase family
RG48_RS05490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG48_RS05495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RG48_RS05505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG48_RS05520	COG2233	PERMEase
RG48_RS05530	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS05530	COG0493	'glutamate synthase
RG48_RS05535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS05540	COG2252	PERMEase
RG48_RS05545	COG0402	S-adenosylhomocysteine deaminase activity
RG48_RS05550	COG2233	PERMEase
RG48_RS05555	COG2080	2 iron, 2 sulfur cluster binding
RG48_RS05555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG48_RS05560	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG48_RS05565	COG0402	S-adenosylhomocysteine deaminase activity
RG48_RS05570	COG0493	'glutamate synthase
RG48_RS05570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS05575	COG2068	MobA-Related Protein
RG48_RS05580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG48_RS05585	COG3608	succinylglutamate desuccinylase aspartoacylase
RG48_RS05585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG48_RS05595	COG0549	Belongs to the carbamate kinase family
RG48_RS05605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG48_RS05610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG48_RS05615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RG48_RS05620	COG3829	transcription factor binding
RG48_RS05625	COG2080	2 iron, 2 sulfur cluster binding
RG48_RS05630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG48_RS05635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG48_RS05645	COG4942	peptidase
RG48_RS05655	COG3387	PFAM Glycoside hydrolase 15-related
RG48_RS05730	COG2197	response regulator
RG48_RS05735	COG2197	response regulator
RG48_RS05750	COG0457	Tetratricopeptide repeat
RG48_RS05750	COG3710	Transcriptional regulator
RG48_RS05760	COG0457	Tetratricopeptide repeat
RG48_RS05785	COG3710	Transcriptional regulator
RG48_RS05790	COG2771	luxR family
RG48_RS05795	COG0814	amino acid
RG48_RS05800	COG0183	Belongs to the thiolase family
RG48_RS05810	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS05815	COG2814	Major facilitator Superfamily
RG48_RS05820	COG1794	racemase activity, acting on amino acids and derivatives
RG48_RS05825	COG0583	DNA-binding transcription factor activity
RG48_RS05835	COG1609	Transcriptional regulator
RG48_RS05855	COG0667	Aldo Keto reductase
RG48_RS05865	COG0861	Integral membrane protein TerC family
RG48_RS05890	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
RG48_RS05905	COG2165	general secretion pathway protein
RG48_RS05910	COG4795	General secretion pathway protein
RG48_RS05920	COG4967	type IV pilus modification protein PilV
RG48_RS05925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RG48_RS05935	COG1074	ATP-dependent DNA helicase activity
RG48_RS05940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RG48_RS05945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RG48_RS05945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RG48_RS05950	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG48_RS05975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RG48_RS05980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RG48_RS05985	COG2166	iron-sulfur cluster assembly
RG48_RS05990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RG48_RS06000	COG0583	DNA-binding transcription factor activity
RG48_RS06005	COG2363	Small membrane protein
RG48_RS06015	COG1349	DNA-binding transcription factor activity
RG48_RS06025	COG1070	Carbohydrate kinase
RG48_RS06035	COG0738	Major facilitator superfamily
RG48_RS06040	COG0235	Class ii aldolase
RG48_RS06045	COG1454	alcohol dehydrogenase
RG48_RS06055	COG1760	l-serine dehydratase
RG48_RS06060	COG0814	amino acid
RG48_RS06065	COG1611	Belongs to the LOG family
RG48_RS06085	COG3098	single-species biofilm formation
RG48_RS06090	COG0564	pseudouridine synthase activity
RG48_RS06095	COG0716	FMN binding
RG48_RS06100	COG2271	Major facilitator Superfamily
RG48_RS06105	COG4948	Mandelate Racemase Muconate Lactonizing
RG48_RS06110	COG4948	Mandelate Racemase Muconate Lactonizing
RG48_RS06115	COG4999	Histidine kinase
RG48_RS06115	COG3850	Histidine kinase
RG48_RS06115	COG3437	response regulator, receiver
RG48_RS06115	COG2205	protein histidine kinase activity
RG48_RS06120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RG48_RS06125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG48_RS06130	COG2336	PFAM SpoVT AbrB
RG48_RS06135	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG48_RS06140	COG3956	TIGRFAM MazG family protein
RG48_RS06155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG48_RS06165	COG0602	queuosine metabolic process
RG48_RS06170	COG1070	Carbohydrate kinase
RG48_RS06175	COG2223	nitrite transmembrane transporter activity
RG48_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS06185	COG0277	FAD linked oxidase domain protein
RG48_RS06190	COG0477	Major facilitator Superfamily
RG48_RS06195	COG2086	electron transfer activity
RG48_RS06200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG48_RS06205	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RG48_RS06210	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG48_RS06215	COG0644	oxidoreductase
RG48_RS06220	COG0720	synthase
RG48_RS06240	COG1203	CRISPR-associated helicase, Cas3
RG48_RS06255	COG1857	crispr-associated protein
RG48_RS06270	COG1518	maintenance of DNA repeat elements
RG48_RS06275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG48_RS06280	COG2234	aminopeptidase activity
RG48_RS06335	COG1388	LysM domain
RG48_RS06335	COG4942	peptidase
RG48_RS06340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG48_RS06345	COG2610	gluconate transmembrane transporter activity
RG48_RS06350	COG3622	Belongs to the hyi family
RG48_RS06355	COG0235	Class ii aldolase
RG48_RS06360	COG3395	kinase activity
RG48_RS06365	COG2084	Dehydrogenase
RG48_RS06370	COG1349	DNA-binding transcription factor activity
RG48_RS06375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG48_RS06395	COG3604	Transcriptional regulator
RG48_RS06400	COG0309	Hydrogenase expression formation protein (HypE)
RG48_RS06405	COG0409	Hydrogenase expression formation protein
RG48_RS06410	COG0298	carbon dioxide binding
RG48_RS06415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RG48_RS06420	COG0375	protein maturation
RG48_RS06435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS06440	COG0651	ATP synthesis coupled electron transport
RG48_RS06445	COG0650	Formate hydrogenlyase subunit 4
RG48_RS06450	COG3261	NADH dehydrogenase
RG48_RS06450	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG48_RS06455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG48_RS06460	COG3260	NADH ubiquinone oxidoreductase 20
RG48_RS06470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG48_RS06475	COG2723	6-phospho-beta-galactosidase activity
RG48_RS06480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS06480	COG1263	PTS System
RG48_RS06485	COG1609	Transcriptional regulator
RG48_RS06490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS06495	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RG48_RS06520	COG0517	IMP dehydrogenase activity
RG48_RS06520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG48_RS06525	COG1349	DNA-binding transcription factor activity
RG48_RS06530	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS06540	COG3731	PTS system glucitol sorbitol-specific IIA component
RG48_RS06545	COG3732	PTS system glucitol sorbitol-specific
RG48_RS06550	COG3730	PTS system glucitol sorbitol-specific
RG48_RS06555	COG2951	lytic endotransglycosylase activity
RG48_RS06560	COG1546	Belongs to the CinA family
RG48_RS06585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RG48_RS06615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG48_RS06620	COG1238	metal cluster binding
RG48_RS06635	COG2814	Major facilitator Superfamily
RG48_RS06640	COG1566	PFAM secretion protein HlyD family protein
RG48_RS06645	COG1846	Transcriptional regulator
RG48_RS06655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RG48_RS06660	COG2814	Major facilitator Superfamily
RG48_RS06665	COG2113	Glycine betaine
RG48_RS06670	COG4176	ABC-type proline glycine betaine transport system permease component
RG48_RS06675	COG4175	Glycine betaine
RG48_RS06680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG48_RS06685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG48_RS06695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG48_RS06700	COG4575	ribosome binding
RG48_RS06715	COG2916	Histone family protein nucleoid-structuring protein H-NS
RG48_RS06720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG48_RS06725	COG0640	Transcriptional regulator
RG48_RS06730	COG0401	homolog of Blt101
RG48_RS06735	COG1652	LysM domain
RG48_RS06740	COG1802	Transcriptional regulator
RG48_RS06745	COG1113	amino acid transport
RG48_RS06750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG48_RS06755	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS06760	COG0579	oxidoreductase
RG48_RS06805	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS06810	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS06830	COG4974	Belongs to the 'phage' integrase family
RG48_RS06900	COG3409	Peptidoglycan-binding domain 1 protein
RG48_RS06900	COG3429	Glucose-6-phosphate dehydrogenase subunit
RG48_RS06920	COG1475	DNA binding
RG48_RS06930	COG0582	viral genome integration into host DNA
RG48_RS06945	COG2867	negative regulation of translational initiation
RG48_RS06955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG48_RS06960	COG0497	DNA recombination
RG48_RS06980	COG4536	flavin adenine dinucleotide binding
RG48_RS06985	COG4137	Cytochrome C assembly protein
RG48_RS06990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RG48_RS07015	COG2885	chlorophyll binding
RG48_RS07020	COG2199	diguanylate cyclase activity
RG48_RS07035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG48_RS07040	COG0287	Prephenate dehydrogenase
RG48_RS07040	COG1605	Chorismate mutase
RG48_RS07045	COG0077	Prephenate dehydratase
RG48_RS07045	COG1605	Chorismate mutase
RG48_RS07050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG48_RS07060	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG48_RS07065	COG0564	pseudouridine synthase activity
RG48_RS07075	COG0542	response to heat
RG48_RS07105	COG0477	Major facilitator Superfamily
RG48_RS07110	COG5544	Lipoprotein
RG48_RS07115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG48_RS07120	COG0045	succinate-CoA ligase (ADP-forming) activity
RG48_RS07120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG48_RS07120	COG1042	CoA-binding domain protein
RG48_RS07125	COG3148	PFAM DTW domain containing protein
RG48_RS07130	COG3118	belongs to the thioredoxin family
RG48_RS07135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG48_RS07155	COG0583	DNA-binding transcription factor activity
RG48_RS07160	COG0513	Belongs to the DEAD box helicase family
RG48_RS07170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG48_RS07180	COG1595	DNA-templated transcription, initiation
RG48_RS07185	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RG48_RS07190	COG3026	antisigma factor binding
RG48_RS07195	COG3086	response to oxidative stress
RG48_RS07205	COG0681	Belongs to the peptidase S26 family
RG48_RS07230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RG48_RS07255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS07260	COG1737	Transcriptional regulator
RG48_RS07265	COG0560	Phosphoserine phosphatase
RG48_RS07290	COG2205	protein histidine kinase activity
RG48_RS07295	COG3170	Tfp pilus assembly protein FimV
RG48_RS07300	COG2204	response regulator
RG48_RS07305	COG0347	Belongs to the P(II) protein family
RG48_RS07310	COG1017	nitric oxide dioxygenase activity
RG48_RS07310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG48_RS07325	COG1940	carbohydrate kinase activity
RG48_RS07330	COG0457	Tetratricopeptide repeat
RG48_RS07335	COG1879	ABC-type sugar transport system periplasmic component
RG48_RS07340	COG1129	ABC transporter
RG48_RS07345	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG48_RS07350	COG1063	alcohol dehydrogenase
RG48_RS07355	COG2017	converts alpha-aldose to the beta-anomer
RG48_RS07360	COG2259	Doxx family
RG48_RS07385	COG4638	Rieske (2fe-2S)
RG48_RS07390	COG0583	DNA-binding transcription factor activity
RG48_RS07395	COG2814	Major facilitator Superfamily
RG48_RS07400	COG3711	transcriptional antiterminator
RG48_RS07405	COG1073	alpha beta
RG48_RS07410	COG0483	inositol monophosphate 1-phosphatase activity
RG48_RS07430	COG0822	iron-sulfur transferase activity
RG48_RS07450	COG0633	Ferredoxin
RG48_RS07455	COG2975	iron-sulfur cluster assembly
RG48_RS07470	COG2897	thiosulfate sulfurtransferase activity
RG48_RS07475	COG2373	Large extracellular alpha-helical protein
RG48_RS07480	COG4953	penicillin-binding protein 1C
RG48_RS07510	COG2976	Protein conserved in bacteria
RG48_RS07525	COG1645	bacterial-type flagellum-dependent swarming motility
RG48_RS07535	COG0516	GMP reductase activity
RG48_RS07535	COG0517	IMP dehydrogenase activity
RG48_RS07550	COG3133	Outer membrane lipoprotein
RG48_RS07570	COG2200	EAL domain
RG48_RS07575	COG0248	Ppx GppA phosphatase
RG48_RS07580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RG48_RS07585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RG48_RS07605	COG2233	PERMEase
RG48_RS07615	COG1393	Belongs to the ArsC family
RG48_RS07620	COG4783	chaperone-mediated protein folding
RG48_RS07625	COG0628	permease
RG48_RS07630	COG2116	formate transmembrane transporter activity
RG48_RS07635	COG3604	Transcriptional regulator
RG48_RS07645	COG3260	NADH ubiquinone oxidoreductase 20
RG48_RS07650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG48_RS07655	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG48_RS07655	COG3261	NADH dehydrogenase
RG48_RS07660	COG0651	ATP synthesis coupled electron transport
RG48_RS07665	COG4237	Hydrogenase 4 membrane
RG48_RS07670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG48_RS07675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG48_RS07680	COG0650	Formate hydrogenlyase subunit 4
RG48_RS07685	COG0650	Formate hydrogenlyase subunit 4
RG48_RS07690	COG0651	ATP synthesis coupled electron transport
RG48_RS07695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS07700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RG48_RS07705	COG2716	regulation of RNA biosynthetic process
RG48_RS07715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RG48_RS07730	COG2321	neutral zinc metallopeptidase
RG48_RS07740	COG0400	carboxylic ester hydrolase activity
RG48_RS07755	COG1393	Belongs to the ArsC family
RG48_RS07765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG48_RS07770	COG3850	Histidine kinase
RG48_RS07775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS07775	COG0493	'glutamate synthase
RG48_RS07785	COG5342	invasion associated locus B
RG48_RS07790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG48_RS07795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG48_RS07800	COG0280	phosphate acetyltransferase
RG48_RS07800	COG0281	malic enzyme
RG48_RS07805	COG4810	utilization protein
RG48_RS07810	COG4917	ethanolamine utilization protein
RG48_RS07815	COG4766	ethanolamine catabolic process
RG48_RS07820	COG4812	Cobalamin adenosyltransferase
RG48_RS07825	COG0280	phosphate acetyltransferase
RG48_RS07830	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG48_RS07835	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RG48_RS07840	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS07845	COG4820	ethanolamine utilization protein (EutJ)
RG48_RS07850	COG1454	alcohol dehydrogenase
RG48_RS07855	COG3192	ethanolamine utilization protein
RG48_RS07860	COG4819	ethanolamine utilization protein
RG48_RS07865	COG4303	Ethanolamine ammonia lyase large subunit
RG48_RS07875	COG4816	utilization protein
RG48_RS07880	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG48_RS07885	COG2207	Transcriptional regulator
RG48_RS07895	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG48_RS07900	COG0456	acetyltransferase
RG48_RS07915	COG2837	iron assimilation
RG48_RS07920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG48_RS07925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS07925	COG1263	PTS System
RG48_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS07945	COG4150	thiosulfate binding
RG48_RS07950	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RG48_RS07955	COG4208	sulfate ABC transporter
RG48_RS07960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RG48_RS07965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG48_RS07970	COG3831	ATPase activity
RG48_RS07970	COG4884	unkown
RG48_RS07985	COG2190	(PTS) system
RG48_RS07990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG48_RS07995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS08000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG48_RS08025	COG3530	Putative quorum-sensing-regulated virulence factor
RG48_RS08030	COG0385	Bile acid
RG48_RS08035	COG0583	DNA-binding transcription factor activity
RG48_RS08075	COG3415	Transposase
RG48_RS08080	COG3415	Transposase
RG48_RS08095	COG2199	diguanylate cyclase activity
RG48_RS08095	COG2200	EAL domain
RG48_RS08100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG48_RS08130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS08135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS08140	COG0006	proline dipeptidase activity
RG48_RS08145	COG1363	Peptidase, m42
RG48_RS08150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS08150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS08150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG48_RS08155	COG2207	Transcriptional regulator
RG48_RS08160	COG3279	Response regulator of the LytR AlgR family
RG48_RS08165	COG3275	phosphorelay sensor kinase activity
RG48_RS08170	COG0436	Aminotransferase
RG48_RS08180	COG1560	Kdo2-lipid A biosynthetic process
RG48_RS08210	COG0028	Belongs to the TPP enzyme family
RG48_RS08215	COG0679	Auxin Efflux Carrier
RG48_RS08220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RG48_RS08225	COG2205	protein histidine kinase activity
RG48_RS08225	COG0784	Response regulator, receiver
RG48_RS08225	COG2198	Histidine kinase
RG48_RS08225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS08230	COG2197	response regulator
RG48_RS08235	COG1566	PFAM secretion protein HlyD family protein
RG48_RS08240	COG0477	Major facilitator Superfamily
RG48_RS08245	COG3039	Transposase
RG48_RS08260	COG2610	gluconate transmembrane transporter activity
RG48_RS08265	COG0583	DNA-binding transcription factor activity
RG48_RS08575	COG0582	viral genome integration into host DNA
RG48_RS08585	COG2116	formate transmembrane transporter activity
RG48_RS08590	COG2853	Lipoprotein
RG48_RS08605	COG2067	long-chain fatty acid transport protein
RG48_RS08615	COG3691	Protein conserved in bacteria
RG48_RS08630	COG2062	phosphohistidine phosphatase, SixA
RG48_RS08635	COG3539	Fimbrial protein
RG48_RS08640	COG3188	usher protein
RG48_RS08645	COG3121	Chaperone
RG48_RS08650	COG3539	Fimbrial protein
RG48_RS08655	COG3539	Fimbrial protein
RG48_RS08660	COG3539	Fimbrial protein
RG48_RS08690	COG0730	response to heat
RG48_RS08695	COG3101	peptidyl-lysine hydroxylation
RG48_RS08710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG48_RS08720	COG2814	Major facilitator Superfamily
RG48_RS08735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG48_RS08745	COG0586	Pfam SNARE associated Golgi protein
RG48_RS08755	COG0285	dihydrofolate synthase activity
RG48_RS08760	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RG48_RS08770	COG1286	toxin biosynthetic process
RG48_RS08775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RG48_RS08780	COG0163	prenyltransferase activity
RG48_RS08785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS08795	COG4215	(ABC) transporter
RG48_RS08800	COG4160	amino acid transport
RG48_RS08805	COG4598	ABC transporter
RG48_RS08815	COG1090	epimerase
RG48_RS08820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG48_RS08825	COG0625	glutathione transferase activity
RG48_RS08830	COG0625	glutathione transferase activity
RG48_RS08835	COG0622	Phosphoesterase
RG48_RS08840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RG48_RS08845	COG1288	antiporter activity
RG48_RS08850	COG0280	phosphate acetyltransferase
RG48_RS08850	COG0857	belongs to the CobB CobQ family
RG48_RS08855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG48_RS08875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG48_RS08880	COG0471	metal ion transport
RG48_RS08880	COG0490	domain, Protein
RG48_RS08890	COG0436	Aminotransferase
RG48_RS08900	COG0583	DNA-binding transcription factor activity
RG48_RS08920	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RG48_RS08925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RG48_RS08930	COG1034	ATP synthesis coupled electron transport
RG48_RS08945	COG0839	Belongs to the complex I subunit 6 family
RG48_RS08955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG48_RS08960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG48_RS08990	COG2234	aminopeptidase activity
RG48_RS09010	COG2153	protein acetylation
RG48_RS09015	COG4575	ribosome binding
RG48_RS09020	COG1169	isochorismate synthase
RG48_RS09035	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RG48_RS09045	COG0318	PFAM AMP-dependent synthetase and ligase
RG48_RS09110	COG1414	Transcriptional regulator
RG48_RS09120	COG2271	Major facilitator Superfamily
RG48_RS09130	COG5464	transposase or invertase
RG48_RS09135	COG0247	lactate metabolic process
RG48_RS09145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG48_RS09150	COG2271	Major facilitator Superfamily
RG48_RS09155	COG0584	glycerophosphoryl diester phosphodiesterase
RG48_RS09160	COG0583	DNA-binding transcription factor activity
RG48_RS09170	COG3642	lipopolysaccharide core region biosynthetic process
RG48_RS09175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG48_RS09180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG48_RS09190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG48_RS09200	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS09210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG48_RS09215	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RG48_RS09220	COG3234	Protein of unknown function (DUF1175)
RG48_RS09225	COG2373	Large extracellular alpha-helical protein
RG48_RS09230	COG5445	Predicted secreted protein (DUF2300)
RG48_RS09235	COG4676	Protein conserved in bacteria
RG48_RS09240	COG0183	Belongs to the thiolase family
RG48_RS09245	COG2031	fatty acid transporter
RG48_RS09250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RG48_RS09255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RG48_RS09260	COG2204	response regulator
RG48_RS09265	COG3852	Histidine kinase
RG48_RS09270	COG2205	protein histidine kinase activity
RG48_RS09270	COG0784	Response regulator, receiver
RG48_RS09280	COG2197	response regulator
RG48_RS09285	COG0642	Histidine kinase
RG48_RS09285	COG2198	Histidine kinase
RG48_RS09300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG48_RS09305	COG1477	protein flavinylation
RG48_RS09310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG48_RS09310	COG2169	Transcriptional regulator
RG48_RS09315	COG3145	DNA-N1-methyladenine dioxygenase activity
RG48_RS09320	COG4615	Cyclic peptide transporter
RG48_RS09350	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS09350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG48_RS09355	COG3062	negative regulation of establishment of protein localization
RG48_RS09365	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS09370	COG0348	domain, Protein
RG48_RS09375	COG3043	anaerobic respiration
RG48_RS09380	COG3005	denitrification pathway
RG48_RS09385	COG4133	protoheme IX ABC transporter activity
RG48_RS09390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG48_RS09395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG48_RS09400	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG48_RS09410	COG1138	Cytochrome C-type biogenesis protein
RG48_RS09415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RG48_RS09420	COG4235	cytochrome complex assembly
RG48_RS09420	COG3088	subunit of a heme lyase
RG48_RS09425	COG2197	response regulator
RG48_RS09435	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS09445	COG3083	sulfuric ester hydrolase activity
RG48_RS09465	COG1061	Type III restriction enzyme res subunit
RG48_RS09475	COG1187	pseudouridine synthase activity
RG48_RS09480	COG2814	Major facilitator Superfamily
RG48_RS09495	COG4172	Belongs to the ABC transporter superfamily
RG48_RS09500	COG4239	(ABC) transporter, permease
RG48_RS09505	COG4174	ABC transporter (Permease)
RG48_RS09510	COG4166	transmembrane transport
RG48_RS09515	COG2200	EAL domain
RG48_RS09520	COG0791	NLP P60 protein
RG48_RS09525	COG0671	phosphoesterase, PA-phosphatase related
RG48_RS09530	COG0523	cobalamin synthesis protein
RG48_RS09535	COG0246	Mannitol dehydrogenase
RG48_RS09550	COG2814	Major facilitator Superfamily
RG48_RS09555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS09555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS09560	COG1105	Belongs to the carbohydrate kinase PfkB family
RG48_RS09565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS09565	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RG48_RS09565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS09570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS09575	COG2313	pseudouridylate synthase activity
RG48_RS09580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG48_RS09585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG48_RS09595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG48_RS09600	COG1522	sequence-specific DNA binding
RG48_RS09600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS09610	COG2855	membrane
RG48_RS09615	COG0583	DNA-binding transcription factor activity
RG48_RS09625	COG0833	amino acid
RG48_RS09630	COG4771	TonB-dependent receptor
RG48_RS09650	COG2311	Membrane
RG48_RS09660	COG1609	Transcriptional regulator
RG48_RS09665	COG1879	ABC-type sugar transport system periplasmic component
RG48_RS09670	COG1129	ABC transporter
RG48_RS09675	COG4211	Belongs to the binding-protein-dependent transport system permease family
RG48_RS09680	COG0167	dihydroorotate dehydrogenase activity
RG48_RS09680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RG48_RS09685	COG0493	'glutamate synthase
RG48_RS09695	COG2949	membrane
RG48_RS09705	COG1346	cytolysis
RG48_RS09715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG48_RS09735	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS09740	COG0586	Pfam SNARE associated Golgi protein
RG48_RS09750	COG1686	Belongs to the peptidase S11 family
RG48_RS09755	COG0277	FAD linked oxidase domain protein
RG48_RS09760	COG1472	Belongs to the glycosyl hydrolase 3 family
RG48_RS09765	COG1732	Glycine betaine
RG48_RS09770	COG1174	glycine betaine transport
RG48_RS09775	COG1125	glycine betaine transport
RG48_RS09780	COG1174	glycine betaine transport
RG48_RS09790	COG0789	Transcriptional regulator
RG48_RS09795	COG3275	phosphorelay sensor kinase activity
RG48_RS09800	COG3279	Response regulator of the LytR AlgR family
RG48_RS09805	COG4807	Protein conserved in bacteria
RG48_RS09810	COG4808	Protein conserved in bacteria
RG48_RS09815	COG4715	Zinc finger, swim domain protein
RG48_RS09820	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RG48_RS09830	COG0714	Associated with various cellular activities
RG48_RS09840	COG3831	ATPase activity
RG48_RS09845	COG3831	ATPase activity
RG48_RS09855	COG0489	protein tyrosine kinase activity
RG48_RS09870	COG3539	Fimbrial protein
RG48_RS09875	COG3121	Chaperone
RG48_RS09880	COG3188	usher protein
RG48_RS09885	COG3539	Fimbrial protein
RG48_RS09890	COG5455	response to cobalt ion
RG48_RS09895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
RG48_RS09930	COG2801	Transposase and inactivated derivatives
RG48_RS09950	COG0351	phosphomethylpyrimidine kinase
RG48_RS09955	COG3757	hydrolase, family 25
RG48_RS09960	COG2188	Transcriptional regulator
RG48_RS09965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS09970	COG1397	ADP-ribosylglycohydrolase
RG48_RS09975	COG2211	Major facilitator Superfamily
RG48_RS09980	COG1830	Aldolase
RG48_RS09995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS10000	COG3414	Phosphotransferase system galactitol-specific IIB component
RG48_RS10005	COG3775	system Galactitol-specific IIC component
RG48_RS10010	COG1063	alcohol dehydrogenase
RG48_RS10035	COG4974	Belongs to the 'phage' integrase family
RG48_RS10090	COG4695	Portal protein
RG48_RS10115	COG0826	peptidase U32
RG48_RS10130	COG0745	RESPONSE REGULATOR receiver
RG48_RS10135	COG2205	protein histidine kinase activity
RG48_RS10170	COG4245	von Willebrand factor, type A
RG48_RS10175	COG0631	protein serine/threonine phosphatase activity
RG48_RS10180	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
RG48_RS10185	COG0443	Heat shock 70 kDa protein
RG48_RS10190	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RG48_RS10195	COG5001	Diguanylate cyclase
RG48_RS10195	COG5002	protein histidine kinase activity
RG48_RS10195	COG3447	MASE1 domain protein
RG48_RS10200	COG0572	uridine kinase
RG48_RS10210	COG2982	Protein involved in outer membrane biogenesis
RG48_RS10215	COG1253	flavin adenine dinucleotide binding
RG48_RS10220	COG1596	polysaccharide export
RG48_RS10225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG48_RS10230	COG3206	protein involved in exopolysaccharide biosynthesis
RG48_RS10230	COG0489	protein tyrosine kinase activity
RG48_RS10235	COG0463	Glycosyl transferase, family 2
RG48_RS10240	COG1045	serine acetyltransferase
RG48_RS10245	COG0438	transferase activity, transferring glycosyl groups
RG48_RS10255	COG1216	Glycosyl transferase, family 2
RG48_RS10260	COG0110	maltose O-acetyltransferase activity
RG48_RS10265	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RG48_RS10270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG48_RS10275	COG1051	belongs to the nudix hydrolase family
RG48_RS10280	COG0297	glycogen (starch) synthase activity
RG48_RS10285	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RG48_RS10285	COG0662	Cupin 2, conserved barrel domain protein
RG48_RS10290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RG48_RS10295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RG48_RS10300	COG2244	polysaccharide biosynthetic process
RG48_RS10310	COG2327	Polysaccharide pyruvyl transferase
RG48_RS10315	COG0438	transferase activity, transferring glycosyl groups
RG48_RS10325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG48_RS10400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RG48_RS10425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RG48_RS10430	COG0131	Imidazoleglycerol-phosphate dehydratase
RG48_RS10430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG48_RS10440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RG48_RS10465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG48_RS10470	COG0583	DNA-binding transcription factor activity
RG48_RS10475	COG0531	amino acid
RG48_RS10480	COG2391	methyltransferase activity
RG48_RS10485	COG0425	Belongs to the sulfur carrier protein TusA family
RG48_RS10490	COG2925	Exonuclease
RG48_RS10495	COG1686	Belongs to the peptidase S11 family
RG48_RS10505	COG1289	transmembrane transporter activity
RG48_RS10525	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RG48_RS10540	COG1376	ErfK ybiS ycfS ynhG family protein
RG48_RS10550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS10555	COG3414	Phosphotransferase system galactitol-specific IIB component
RG48_RS10560	COG3775	system Galactitol-specific IIC component
RG48_RS10565	COG0698	ribose 5-phosphate isomerase
RG48_RS10570	COG1349	DNA-binding transcription factor activity
RG48_RS10580	COG3414	Phosphotransferase system galactitol-specific IIB component
RG48_RS10585	COG3775	system Galactitol-specific IIC component
RG48_RS10590	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG48_RS10595	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS10600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG48_RS10625	COG3209	COG3209 Rhs family protein
RG48_RS10665	COG0583	DNA-binding transcription factor activity
RG48_RS10670	COG0583	DNA-binding transcription factor activity
RG48_RS10680	COG0534	Mate efflux family protein
RG48_RS10695	COG0217	transcriptional regulatory protein
RG48_RS10700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RG48_RS10705	COG0477	Major facilitator Superfamily
RG48_RS10715	COG1470	cell adhesion involved in biofilm formation
RG48_RS10715	COG1388	LysM domain
RG48_RS10720	COG3039	Transposase
RG48_RS10760	COG3038	cytochrome b561
RG48_RS10765	COG3443	Belongs to the bacterial solute-binding protein 9 family
RG48_RS10780	COG2351	hydroxyisourate hydrolase activity
RG48_RS10785	COG0745	RESPONSE REGULATOR receiver
RG48_RS10790	COG2205	protein histidine kinase activity
RG48_RS10805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG48_RS10820	COG1418	mRNA catabolic process
RG48_RS10825	COG0270	DNA (cytosine-5-)-methyltransferase activity
RG48_RS10830	COG3727	T/G mismatch-specific endonuclease activity
RG48_RS10835	COG0697	spore germination
RG48_RS10840	COG2354	Protein conserved in bacteria
RG48_RS10845	COG5475	Uncharacterized small protein (DUF2158)
RG48_RS10880	COG2197	response regulator
RG48_RS10885	COG1684	flagellar biosynthetic protein fliR
RG48_RS10890	COG1987	bacterial-type flagellum assembly
RG48_RS10895	COG1338	Plays a role in the flagellum-specific transport system
RG48_RS10900	COG3190	flagellar
RG48_RS10905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG48_RS10910	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG48_RS10915	COG1580	Controls the rotational direction of flagella during chemotaxis
RG48_RS10920	COG3144	bacterial-type flagellum assembly
RG48_RS10925	COG2882	bacterial-type flagellum organization
RG48_RS10930	COG1157	protein secretion by the type III secretion system
RG48_RS10935	COG1317	bacterial-type flagellum organization
RG48_RS10940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG48_RS10945	COG1766	The M ring may be actively involved in energy transduction
RG48_RS10970	COG2135	peptidase activity
RG48_RS10975	COG0425	Belongs to the sulfur carrier protein TusA family
RG48_RS10980	COG2391	methyltransferase activity
RG48_RS10995	COG0366	Alpha amylase catalytic
RG48_RS11005	COG1516	flagellar protein fliS
RG48_RS11010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RG48_RS11025	COG1191	sigma factor activity
RG48_RS11035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS11045	COG0765	amino acid transport
RG48_RS11050	COG1126	abc transporter atp-binding protein
RG48_RS11055	COG2197	response regulator
RG48_RS11070	COG2197	response regulator
RG48_RS11100	COG3012	SEC-C Motif Domain Protein
RG48_RS11100	COG3318	Belongs to the UPF0149 family
RG48_RS11105	COG0814	amino acid
RG48_RS11115	COG1528	Iron-storage protein
RG48_RS11140	COG1528	Iron-storage protein
RG48_RS11150	COG1879	ABC-type sugar transport system periplasmic component
RG48_RS11155	COG1129	ABC transporter
RG48_RS11160	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG48_RS11165	COG1877	trehalose-phosphatase activity
RG48_RS11175	COG0589	response to stress
RG48_RS11190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RG48_RS11195	COG1360	Flagellar Motor Protein
RG48_RS11200	COG0643	Histidine kinase
RG48_RS11200	COG2198	Histidine kinase
RG48_RS11205	COG0835	chemotaxis
RG48_RS11210	COG0840	transmembrane signaling receptor activity
RG48_RS11215	COG0840	transmembrane signaling receptor activity
RG48_RS11220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RG48_RS11230	COG0745	RESPONSE REGULATOR receiver
RG48_RS11235	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RG48_RS11240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG48_RS11245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG48_RS11255	COG3755	Protein conserved in bacteria
RG48_RS11270	COG3102	Protein conserved in bacteria
RG48_RS11280	COG3005	denitrification pathway
RG48_RS11285	COG0243	molybdopterin cofactor binding
RG48_RS11300	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RG48_RS11305	COG1801	Protein of unknown function DUF72
RG48_RS11320	COG0494	nUDIX hydrolase
RG48_RS11325	COG0217	transcriptional regulatory protein
RG48_RS11355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG48_RS11365	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RG48_RS11370	COG0739	heme binding
RG48_RS11375	COG1560	Kdo2-lipid A biosynthetic process
RG48_RS11380	COG0469	pyruvate kinase activity
RG48_RS11385	COG1737	Transcriptional regulator
RG48_RS11400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RG48_RS11405	COG0129	dihydroxy-acid dehydratase activity
RG48_RS11410	COG0800	Aldolase
RG48_RS11420	COG3141	response to X-ray
RG48_RS11440	COG2979	Protein of unknown function (DUF533)
RG48_RS11450	COG1770	oligopeptidase
RG48_RS11455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG48_RS11460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG48_RS11470	COG2372	response to copper ion
RG48_RS11475	COG1276	copper resistance
RG48_RS11490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG48_RS11510	COG3008	intermembrane lipid transfer
RG48_RS11515	COG2995	paraquat-inducible protein a
RG48_RS11520	COG1956	GAF domain-containing protein
RG48_RS11530	COG0793	Belongs to the peptidase S41A family
RG48_RS11540	COG2814	Major facilitator Superfamily
RG48_RS11545	COG1414	Transcriptional regulator
RG48_RS11580	COG2226	methyltransferase
RG48_RS11600	COG3716	PTS system mannose fructose sorbose family IID component
RG48_RS11605	COG3715	PTS system
RG48_RS11610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS11610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS11625	COG1253	flavin adenine dinucleotide binding
RG48_RS11630	COG2200	EAL domain
RG48_RS11635	COG1760	l-serine dehydratase
RG48_RS11645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG48_RS11665	COG3039	Transposase
RG48_RS11670	COG0251	oxidation-reduction process
RG48_RS11675	COG1199	ATP-dependent helicase activity
RG48_RS11680	COG1214	PFAM Peptidase M22, glycoprotease
RG48_RS11685	COG3065	identical protein binding
RG48_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
RG48_RS11695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RG48_RS11700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG48_RS11705	COG4638	Rieske (2fe-2S)
RG48_RS11710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG48_RS11715	COG0473	3-isopropylmalate dehydrogenase activity
RG48_RS11720	COG0583	DNA-binding transcription factor activity
RG48_RS11730	COG3615	Tellurite resistance protein tehB
RG48_RS11740	COG2261	transglycosylase associated protein
RG48_RS11755	COG2199	diguanylate cyclase activity
RG48_RS11755	COG2203	Gaf domain
RG48_RS11760	COG3042	response to heat
RG48_RS11765	COG3189	MarR family transcriptional regulator
RG48_RS11770	COG2807	transmembrane transport
RG48_RS11775	COG2207	Transcriptional regulator
RG48_RS11790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG48_RS11795	COG2199	diguanylate cyclase activity
RG48_RS11800	COG2199	diguanylate cyclase activity
RG48_RS11810	COG2766	serine protein kinase
RG48_RS11815	COG3713	MltA-interacting MipA family protein
RG48_RS11820	COG0656	L-ascorbic acid biosynthetic process
RG48_RS11825	COG0676	glucose-6-phosphate 1-epimerase activity
RG48_RS11830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG48_RS11840	COG3139	Protein of unknown function (DUF1315)
RG48_RS11845	COG1063	alcohol dehydrogenase
RG48_RS11850	COG2271	Major facilitator Superfamily
RG48_RS11855	COG1063	alcohol dehydrogenase
RG48_RS11860	COG0191	fructose-bisphosphate aldolase activity
RG48_RS11865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS11870	COG0667	Aldo Keto reductase
RG48_RS11875	COG1349	DNA-binding transcription factor activity
RG48_RS11880	COG2814	Major facilitator Superfamily
RG48_RS11885	COG1335	isochorismatase
RG48_RS11890	COG0252	asparaginase activity
RG48_RS11895	COG0616	signal peptide processing
RG48_RS11900	COG0778	Nitroreductase
RG48_RS11915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG48_RS11925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RG48_RS11935	COG0494	nUDIX hydrolase
RG48_RS11940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG48_RS11945	COG2897	thiosulfate sulfurtransferase activity
RG48_RS11950	COG4136	ATPase activity
RG48_RS11955	COG4135	transport system, permease component
RG48_RS11960	COG4134	Bacterial extracellular solute-binding protein
RG48_RS11965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG48_RS11970	COG0398	Pfam SNARE associated Golgi protein
RG48_RS11980	COG0398	Pfam SNARE associated Golgi protein
RG48_RS11985	COG0708	Exodeoxyribonuclease III
RG48_RS12020	COG3678	ATP-independent chaperone mediated protein folding
RG48_RS12030	COG0322	excinuclease ABC activity
RG48_RS12040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG48_RS12050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG48_RS12055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG48_RS12060	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG48_RS12065	COG2169	Transcriptional regulator
RG48_RS12065	COG1917	Cupin 2, conserved barrel domain protein
RG48_RS12070	COG1486	melibiose metabolic process
RG48_RS12085	COG0753	catalase activity
RG48_RS12105	COG1823	symporter activity
RG48_RS12110	COG1988	membrane-bound metal-dependent
RG48_RS12115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG48_RS12125	COG3001	Fructosamine kinase
RG48_RS12135	COG1105	Belongs to the carbohydrate kinase PfkB family
RG48_RS12140	COG3137	Salt-induced outer membrane protein
RG48_RS12200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG48_RS12200	COG0072	phenylalanine-tRNA ligase activity
RG48_RS12215	COG0386	Belongs to the glutathione peroxidase family
RG48_RS12225	COG0791	NLP P60 protein
RG48_RS12230	COG2200	EAL domain
RG48_RS12240	COG4256	Hemin uptake protein
RG48_RS12245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG48_RS12255	COG0574	Belongs to the PEP-utilizing enzyme family
RG48_RS12255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG48_RS12260	COG0318	PFAM AMP-dependent synthetase and ligase
RG48_RS12265	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG48_RS12270	COG0644	oxidoreductase
RG48_RS12275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG48_RS12280	COG2086	electron transfer activity
RG48_RS12290	COG2207	Transcriptional regulator
RG48_RS12290	COG1917	Cupin 2, conserved barrel domain protein
RG48_RS12295	COG1960	acyl-CoA dehydrogenase activity
RG48_RS12300	COG4670	ketone body catabolic process
RG48_RS12315	COG2271	Major facilitator Superfamily
RG48_RS12320	COG0738	Major facilitator superfamily
RG48_RS12335	COG0628	permease
RG48_RS12345	COG0247	lactate metabolic process
RG48_RS12345	COG0277	FAD linked oxidase domain protein
RG48_RS12350	COG2050	protein possibly involved in aromatic compounds catabolism
RG48_RS12360	COG0316	Belongs to the HesB IscA family
RG48_RS12365	COG0719	Fe-S assembly protein
RG48_RS12370	COG0396	ATPase activity
RG48_RS12375	COG0719	Fe-S assembly protein
RG48_RS12390	COG1376	ErfK ybiS ycfS ynhG family protein
RG48_RS12395	COG4238	major outer membrane lipoprotein
RG48_RS12400	COG0469	pyruvate kinase activity
RG48_RS12410	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS12415	COG2414	aldehyde ferredoxin oxidoreductase
RG48_RS12425	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS12430	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RG48_RS12440	COG4529	Protein conserved in bacteria
RG48_RS12460	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS12470	COG0307	riboflavin synthase, alpha
RG48_RS12475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RG48_RS12480	COG2814	Major facilitator Superfamily
RG48_RS12485	COG0583	DNA-binding transcription factor activity
RG48_RS12505	COG2814	Major facilitator Superfamily
RG48_RS12510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG48_RS12515	COG0791	NLP P60 protein
RG48_RS12520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RG48_RS12525	COG1201	RNA secondary structure unwinding
RG48_RS12535	COG0346	lactoylglutathione lyase activity
RG48_RS12540	COG1902	pentaerythritol trinitrate reductase activity
RG48_RS12545	COG1309	transcriptional regulator
RG48_RS12550	COG3313	Fe-S protein
RG48_RS12555	COG4989	oxidoreductase activity
RG48_RS12560	COG2032	superoxide dismutase activity
RG48_RS12565	COG1289	transmembrane transporter activity
RG48_RS12570	COG1566	PFAM secretion protein HlyD family protein
RG48_RS12585	COG3133	Outer membrane lipoprotein
RG48_RS12595	COG3895	Periplasmic Protein
RG48_RS12610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RG48_RS12615	COG0625	glutathione transferase activity
RG48_RS12620	COG3104	oligopeptide transport
RG48_RS12630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RG48_RS12640	COG4659	FMN binding
RG48_RS12685	COG0673	inositol 2-dehydrogenase activity
RG48_RS12695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RG48_RS12700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS12700	COG1263	PTS System
RG48_RS12705	COG1609	Transcriptional regulator
RG48_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS12715	COG1309	transcriptional regulator
RG48_RS12720	COG3250	beta-galactosidase activity
RG48_RS12735	COG5339	Protein conserved in bacteria
RG48_RS12740	COG1482	cell wall glycoprotein biosynthetic process
RG48_RS12745	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG48_RS12745	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG48_RS12750	COG0114	fumarate hydratase activity
RG48_RS12760	COG2205	protein histidine kinase activity
RG48_RS12765	COG0745	RESPONSE REGULATOR receiver
RG48_RS12770	COG3136	membrane protein required for alginate biosynthesis
RG48_RS12780	COG0531	amino acid
RG48_RS12795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RG48_RS12800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RG48_RS12805	COG0628	permease
RG48_RS12820	COG3591	Belongs to the peptidase S1B family
RG48_RS12840	COG2814	Major facilitator Superfamily
RG48_RS12845	COG0583	DNA-binding transcription factor activity
RG48_RS12850	COG1940	carbohydrate kinase activity
RG48_RS12855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG48_RS12865	COG3381	protein complex oligomerization
RG48_RS12870	COG3302	dmso reductase anchor subunit
RG48_RS12875	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS12880	COG0243	molybdopterin cofactor binding
RG48_RS12885	COG0243	molybdopterin cofactor binding
RG48_RS12900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG48_RS12920	COG4948	Mandelate Racemase Muconate Lactonizing
RG48_RS12925	COG1063	alcohol dehydrogenase
RG48_RS12935	COG0582	viral genome integration into host DNA
RG48_RS12960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG48_RS12970	COG1846	Transcriptional regulator
RG48_RS13000	COG1403	HNH endonuclease
RG48_RS13005	COG0484	heat shock protein binding
RG48_RS13015	COG1278	Cold shock
RG48_RS13030	COG3772	lysozyme
RG48_RS13040	COG1278	Cold shock
RG48_RS13090	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG48_RS13095	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG48_RS13100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG48_RS13105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG48_RS13115	COG0477	Major facilitator Superfamily
RG48_RS13120	COG0246	Mannitol dehydrogenase
RG48_RS13130	COG1802	Transcriptional regulator
RG48_RS13135	COG4221	oxidoreductase activity
RG48_RS13140	COG0339	signal peptide processing
RG48_RS13145	COG1546	Belongs to the CinA family
RG48_RS13150	COG3111	PFAM Bacterial OB fold (BOF) protein
RG48_RS13155	COG3706	GGDEF domain
RG48_RS13165	COG2814	Major facilitator Superfamily
RG48_RS13170	COG0697	spore germination
RG48_RS13180	COG4977	sequence-specific DNA binding
RG48_RS13185	COG1846	Transcriptional regulator
RG48_RS13205	COG0583	DNA-binding transcription factor activity
RG48_RS13210	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS13215	COG2066	Belongs to the glutaminase family
RG48_RS13225	COG2199	diguanylate cyclase activity
RG48_RS13245	COG3781	membrane
RG48_RS13295	COG3210	domain, Protein
RG48_RS13295	COG2911	Protein conserved in bacteria
RG48_RS13300	COG1396	sequence-specific DNA binding
RG48_RS13305	COG3550	peptidyl-serine autophosphorylation
RG48_RS13315	COG4977	sequence-specific DNA binding
RG48_RS13320	COG3539	Fimbrial protein
RG48_RS13330	COG3188	usher protein
RG48_RS13335	COG3539	Fimbrial protein
RG48_RS13340	COG3539	Fimbrial protein
RG48_RS13345	COG3539	Fimbrial protein
RG48_RS13350	COG0243	molybdopterin cofactor binding
RG48_RS13360	COG2207	Transcriptional regulator
RG48_RS13365	COG3119	arylsulfatase activity
RG48_RS13370	COG0641	radical SAM
RG48_RS13375	COG4178	(ABC) transporter
RG48_RS13380	COG4771	TonB-dependent receptor
RG48_RS13385	COG0612	Peptidase, M16
RG48_RS13400	COG0076	glutamate decarboxylase activity
RG48_RS13405	COG0531	amino acid
RG48_RS13410	COG1649	PFAM Uncharacterised BCR, COG1649
RG48_RS13415	COG3706	GGDEF domain
RG48_RS13420	COG2202	Pas domain
RG48_RS13420	COG2199	diguanylate cyclase activity
RG48_RS13420	COG2200	EAL domain
RG48_RS13425	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RG48_RS13430	COG0747	negative chemotaxis
RG48_RS13435	COG0601	transmembrane transport
RG48_RS13440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG48_RS13445	COG0444	Belongs to the ABC transporter superfamily
RG48_RS13450	COG4608	Belongs to the ABC transporter superfamily
RG48_RS13455	COG1764	response to oxidative stress
RG48_RS13480	COG1064	alcohol dehydrogenase
RG48_RS13485	COG3093	addiction module antidote protein HigA
RG48_RS13495	COG2864	formate dehydrogenase
RG48_RS13500	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS13510	COG0697	spore germination
RG48_RS13515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG48_RS13520	COG4886	Leucine-rich repeat (LRR) protein
RG48_RS13525	COG4886	Leucine-rich repeat (LRR) protein
RG48_RS13530	COG2223	nitrite transmembrane transporter activity
RG48_RS13535	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG48_RS13540	COG1140	nitrate reductase beta subunit
RG48_RS13545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG48_RS13550	COG2181	nitrate reductase activity
RG48_RS13555	COG0384	phenazine biosynthesis protein PhzF
RG48_RS13560	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RG48_RS13565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG48_RS13575	COG5433	transposase activity
RG48_RS13595	COG3209	COG3209 Rhs family protein
RG48_RS13610	COG0625	glutathione transferase activity
RG48_RS13615	COG1113	amino acid transport
RG48_RS13620	COG3391	amine dehydrogenase activity
RG48_RS13635	COG4772	TonB-dependent receptor
RG48_RS13640	COG1802	Transcriptional regulator
RG48_RS13645	COG2130	NADP-dependent
RG48_RS13655	COG1247	-acetyltransferase
RG48_RS13660	COG3238	Protein conserved in bacteria
RG48_RS13690	COG1177	transmembrane transport
RG48_RS13695	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG48_RS13700	COG3842	ATPase activity
RG48_RS13705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG48_RS13710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG48_RS13715	COG1598	PFAM Uncharacterised protein family UPF0150
RG48_RS13730	COG0826	peptidase U32
RG48_RS13735	COG1396	sequence-specific DNA binding
RG48_RS13740	COG3135	benzoate transporter
RG48_RS13745	COG0675	Transposase, IS605 OrfB family
RG48_RS13760	COG0500	methyltransferase
RG48_RS13765	COG1275	C4-dicarboxylate transporter malic acid transport protein
RG48_RS13770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG48_RS13775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG48_RS13780	COG2841	Protein conserved in bacteria
RG48_RS13800	COG5383	Protein conserved in bacteria
RG48_RS13805	COG0583	DNA-binding transcription factor activity
RG48_RS13810	COG0840	transmembrane signaling receptor activity
RG48_RS13815	COG3039	Transposase
RG48_RS13825	COG2963	transposase activity
RG48_RS13830	COG2801	Transposase and inactivated derivatives
RG48_RS13845	COG3038	cytochrome b561
RG48_RS13850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG48_RS13855	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS13860	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG48_RS13865	COG1643	Atp-dependent helicase
RG48_RS13875	COG2453	phosphatase
RG48_RS13875	COG0671	phosphoesterase, PA-phosphatase related
RG48_RS13880	COG2267	carboxylic ester hydrolase activity
RG48_RS13885	COG4589	Belongs to the CDS family
RG48_RS13890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG48_RS13900	COG0667	Aldo Keto reductase
RG48_RS13910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG48_RS13915	COG3327	negative regulation of DNA-templated transcription, initiation
RG48_RS13920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RG48_RS13925	COG0183	Belongs to the thiolase family
RG48_RS13930	COG2050	protein possibly involved in aromatic compounds catabolism
RG48_RS13935	COG1250	3-hydroxyacyl-CoA dehydrogenase
RG48_RS13940	COG1024	Enoyl-CoA hydratase
RG48_RS13945	COG1024	Enoyl-CoA hydratase
RG48_RS13950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG48_RS13955	COG2151	metal-sulfur cluster biosynthetic enzyme
RG48_RS13960	COG3396	Phenylacetate-CoA oxygenase
RG48_RS13965	COG3460	Phenylacetate-CoA oxygenase
RG48_RS13970	COG3396	Phenylacetate-CoA oxygenase
RG48_RS13975	COG2030	dehydratase
RG48_RS13975	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS13980	COG3733	amine oxidase
RG48_RS13985	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS13990	COG2207	Transcriptional regulator
RG48_RS13995	COG3784	Protein of unknown function (DUF1318)
RG48_RS14005	COG2911	Protein conserved in bacteria
RG48_RS14010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RG48_RS14015	COG3187	Heat shock protein
RG48_RS14020	COG3042	response to heat
RG48_RS14025	COG1013	pyruvate-flavodoxin oxidoreductase activity
RG48_RS14025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RG48_RS14025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG48_RS14025	COG0674	pyruvate-flavodoxin oxidoreductase activity
RG48_RS14030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG48_RS14035	COG0589	response to stress
RG48_RS14045	COG0513	Belongs to the DEAD box helicase family
RG48_RS14060	COG3706	GGDEF domain
RG48_RS14065	COG2840	Smr protein MutS2
RG48_RS14080	COG1473	amidohydrolase
RG48_RS14085	COG1473	amidohydrolase
RG48_RS14095	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RG48_RS14100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG48_RS14105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG48_RS14110	COG0589	response to stress
RG48_RS14115	COG3182	Iron-regulated membrane protein
RG48_RS14120	COG0668	transmembrane transport
RG48_RS14125	COG4166	transmembrane transport
RG48_RS14135	COG0583	DNA-binding transcription factor activity
RG48_RS14140	COG0583	DNA-binding transcription factor activity
RG48_RS14145	COG1073	alpha beta
RG48_RS14150	COG0702	epimerase
RG48_RS14155	COG2866	Carboxypeptidase
RG48_RS14160	COG4948	Mandelate Racemase Muconate Lactonizing
RG48_RS14165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RG48_RS14170	COG3283	Transcriptional regulator of aromatic amino acids metabolism
RG48_RS14180	COG3106	COG3106 Predicted ATPase
RG48_RS14185	COG1609	Transcriptional regulator
RG48_RS14195	COG3842	ATPase activity
RG48_RS14200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG48_RS14205	COG1554	hydrolase, family 65, central catalytic
RG48_RS14215	COG1082	Xylose isomerase domain protein TIM barrel
RG48_RS14220	COG1063	alcohol dehydrogenase
RG48_RS14225	COG0395	ABC-type sugar transport system, permease component
RG48_RS14230	COG1175	transmembrane transport
RG48_RS14235	COG1653	transport
RG48_RS14240	COG0366	Alpha amylase catalytic
RG48_RS14245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG48_RS14255	COG1983	PspC domain protein
RG48_RS14265	COG1842	Phage shock protein A
RG48_RS14270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RG48_RS14275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG48_RS14280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RG48_RS14285	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS14295	COG1917	Cupin 2, conserved barrel domain protein
RG48_RS14295	COG1396	sequence-specific DNA binding
RG48_RS14300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RG48_RS14305	COG0174	glutamine synthetase
RG48_RS14310	COG0531	amino acid
RG48_RS14325	COG4166	transmembrane transport
RG48_RS14330	COG4168	peptide transport system, permease
RG48_RS14335	COG4171	peptide transport system, permease
RG48_RS14340	COG4172	Belongs to the ABC transporter superfamily
RG48_RS14345	COG4172	Belongs to the ABC transporter superfamily
RG48_RS14350	COG2852	Protein conserved in bacteria
RG48_RS14355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RG48_RS14360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG48_RS14360	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG48_RS14375	COG5001	Diguanylate cyclase
RG48_RS14385	COG1349	DNA-binding transcription factor activity
RG48_RS14395	COG0023	Translation Initiation Factor
RG48_RS14405	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RG48_RS14410	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RG48_RS14415	COG0671	phosphoesterase, PA-phosphatase related
RG48_RS14425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG48_RS14445	COG0583	DNA-binding transcription factor activity
RG48_RS14455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG48_RS14465	COG0616	signal peptide processing
RG48_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS14480	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RG48_RS14485	COG1187	pseudouridine synthase activity
RG48_RS14490	COG4907	membrane protein (DUF2207)
RG48_RS14495	COG4907	membrane protein (DUF2207)
RG48_RS14500	COG0009	L-threonylcarbamoyladenylate synthase
RG48_RS14505	COG0613	PHP domain protein
RG48_RS14515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG48_RS14520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG48_RS14520	COG0512	Glutamine amidotransferase of anthranilate synthase
RG48_RS14525	COG0135	phosphoribosylanthranilate isomerase activity
RG48_RS14525	COG0134	indole-3-glycerol-phosphate synthase activity
RG48_RS14540	COG3729	General stress protein
RG48_RS14545	COG3685	Protein conserved in bacteria
RG48_RS14550	COG3685	Protein conserved in bacteria
RG48_RS14555	COG3047	cAMP biosynthetic process
RG48_RS14570	COG1607	acyl-coa hydrolase
RG48_RS14575	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RG48_RS14580	COG2350	Protein conserved in bacteria
RG48_RS14585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG48_RS14660	COG1196	nuclear chromosome segregation
RG48_RS14785	COG3772	lysozyme
RG48_RS14800	COG0484	heat shock protein binding
RG48_RS14930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG48_RS14955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG48_RS14975	COG4608	Belongs to the ABC transporter superfamily
RG48_RS14980	COG0444	Belongs to the ABC transporter superfamily
RG48_RS14985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG48_RS14990	COG0601	transmembrane transport
RG48_RS14995	COG4166	transmembrane transport
RG48_RS15005	COG2095	MarC family integral membrane protein
RG48_RS15010	COG1454	alcohol dehydrogenase
RG48_RS15010	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS15015	COG1435	thymidine kinase activity
RG48_RS15025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG48_RS15030	COG0745	RESPONSE REGULATOR receiver
RG48_RS15035	COG1752	Esterase of the alpha-beta hydrolase superfamily
RG48_RS15045	COG0788	formyltetrahydrofolate deformylase activity
RG48_RS15065	COG2181	nitrate reductase activity
RG48_RS15070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG48_RS15075	COG1140	nitrate reductase beta subunit
RG48_RS15080	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG48_RS15085	COG2223	nitrite transmembrane transporter activity
RG48_RS15095	COG3850	Histidine kinase
RG48_RS15100	COG2197	response regulator
RG48_RS15105	COG4932	domain protein
RG48_RS15110	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RG48_RS15115	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RG48_RS15120	COG4572	Cation transport regulator
RG48_RS15125	COG0387	Pfam Sodium calcium exchanger
RG48_RS15155	COG2912	Transglutaminase-like superfamily
RG48_RS15160	COG3094	Invasion gene expression up-regulator, SirB
RG48_RS15165	COG2890	protein-(glutamine-N5) methyltransferase activity
RG48_RS15190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RG48_RS15195	COG0659	secondary active sulfate transmembrane transporter activity
RG48_RS15210	COG0012	GTP binding
RG48_RS15215	COG0582	viral genome integration into host DNA
RG48_RS15245	COG1204	response to ionizing radiation
RG48_RS15280	COG4974	Belongs to the 'phage' integrase family
RG48_RS15285	COG2003	Belongs to the UPF0758 family
RG48_RS15300	COG1396	sequence-specific DNA binding
RG48_RS15375	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS15385	COG3039	Transposase
RG48_RS15390	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS15395	COG3284	Transcriptional regulator
RG48_RS15400	COG2376	Dihydroxyacetone kinase
RG48_RS15405	COG1461	Dihydroxyacetone kinase
RG48_RS15410	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RG48_RS15410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS15410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG48_RS15435	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RG48_RS15450	COG1619	proteins homologs of microcin C7 resistance protein MccF
RG48_RS15460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG48_RS15470	COG2719	SpoVR family
RG48_RS15485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RG48_RS15490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RG48_RS15495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RG48_RS15515	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG48_RS15545	COG2894	cell division
RG48_RS15630	COG2200	EAL domain
RG48_RS15635	COG0789	Transcriptional regulator
RG48_RS15640	COG5562	phage envelope protein
RG48_RS15655	COG0538	isocitrate dehydrogenase activity
RG48_RS15660	COG1187	pseudouridine synthase activity
RG48_RS15680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RG48_RS15685	COG0745	RESPONSE REGULATOR receiver
RG48_RS15690	COG2205	protein histidine kinase activity
RG48_RS15695	COG2850	peptidyl-arginine hydroxylation
RG48_RS15720	COG1177	transmembrane transport
RG48_RS15725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG48_RS15730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RG48_RS15740	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG48_RS15745	COG1136	(ABC) transporter
RG48_RS15750	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG48_RS15755	COG4763	Acyl-transferase
RG48_RS15760	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RG48_RS15765	COG1388	LysM domain
RG48_RS15765	COG1376	ErfK ybiS ycfS ynhG family protein
RG48_RS15775	COG1309	transcriptional regulator
RG48_RS15780	COG3134	Outer membrane lipoprotein
RG48_RS15785	COG1252	NADH dehydrogenase
RG48_RS15805	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
RG48_RS15810	COG5633	Lipoprotein
RG48_RS15815	COG0537	adenosine 5'-monophosphoramidase activity
RG48_RS15820	COG4773	Receptor
RG48_RS15825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS15825	COG1263	PTS System
RG48_RS15830	COG0084	hydrolase, TatD family'
RG48_RS15835	COG0470	DNA polymerase III
RG48_RS15845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RG48_RS15850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG48_RS15855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG48_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS15870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RG48_RS15890	COG1399	metal-binding, possibly nucleic acid-binding protein
RG48_RS15895	COG0424	maF-like protein
RG48_RS15900	COG0564	pseudouridine synthase activity
RG48_RS15910	COG1530	ribonuclease E activity
RG48_RS15915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG48_RS15920	COG1256	bacterial-type flagellum assembly
RG48_RS15925	COG1705	Flagellar rod assembly protein muramidase FlgJ
RG48_RS15925	COG3951	Flagellar rod assembly protein muramidase FlgJ
RG48_RS15940	COG4786	Flagellar basal body rod
RG48_RS15945	COG4787	bacterial-type flagellum-dependent cell motility
RG48_RS15950	COG1749	Flagellar hook protein flgE
RG48_RS15955	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RG48_RS15960	COG1558	bacterial-type flagellum-dependent cell motility
RG48_RS15965	COG1815	bacterial-type flagellum-dependent cell motility
RG48_RS15970	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RG48_RS15975	COG2747	anti-sigma28 factor FlgM
RG48_RS15980	COG3418	PFAM FlgN family protein
RG48_RS15985	COG0728	peptidoglycan biosynthetic process
RG48_RS15990	COG0673	inositol 2-dehydrogenase activity
RG48_RS16000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG48_RS16010	COG2999	glutathione oxidoreductase activity
RG48_RS16050	COG3038	cytochrome b561
RG48_RS16055	COG2353	YceI-like domain
RG48_RS16065	COG1560	Kdo2-lipid A biosynthetic process
RG48_RS16085	COG5645	(Lipo)protein
RG48_RS16090	COG2943	transferase activity, transferring hexosyl groups
RG48_RS16105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG48_RS16110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG48_RS16145	COG2197	response regulator
RG48_RS16160	COG1462	curli production assembly transport component CsgG
RG48_RS16170	COG3381	protein complex oligomerization
RG48_RS16205	COG2801	Transposase and inactivated derivatives
RG48_RS16210	COG3706	GGDEF domain
RG48_RS16215	COG0457	Tetratricopeptide repeat
RG48_RS16220	COG0726	polysaccharide deacetylase
RG48_RS16220	COG1649	PFAM Uncharacterised BCR, COG1649
RG48_RS16225	COG1215	transferase activity, transferring glycosyl groups
RG48_RS16230	COG3658	cytochrome
RG48_RS16235	COG1702	phosphate starvation-inducible protein PhoH
RG48_RS16250	COG2822	iron ion transport
RG48_RS16265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG48_RS16280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG48_RS16280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG48_RS16280	COG0506	proline dehydrogenase activity
RG48_RS16285	COG1309	transcriptional regulator
RG48_RS16295	COG1335	isochorismatase
RG48_RS16320	COG2233	PERMEase
RG48_RS16330	COG3729	General stress protein
RG48_RS16375	COG0243	molybdopterin cofactor binding
RG48_RS16380	COG3005	denitrification pathway
RG48_RS16385	COG0745	RESPONSE REGULATOR receiver
RG48_RS16390	COG1879	ABC-type sugar transport system periplasmic component
RG48_RS16395	COG2198	Histidine kinase
RG48_RS16395	COG2205	protein histidine kinase activity
RG48_RS16395	COG0784	Response regulator, receiver
RG48_RS16400	COG0348	domain, Protein
RG48_RS16420	COG1278	Cold shock
RG48_RS16425	COG1278	Cold shock
RG48_RS16445	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG48_RS16450	COG1596	polysaccharide export
RG48_RS16455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG48_RS16460	COG0489	protein tyrosine kinase activity
RG48_RS16460	COG3206	protein involved in exopolysaccharide biosynthesis
RG48_RS16465	COG3206	protein involved in exopolysaccharide biosynthesis
RG48_RS16465	COG0489	protein tyrosine kinase activity
RG48_RS16480	COG1294	oxidase, subunit
RG48_RS16485	COG1271	oxidase subunit
RG48_RS16490	COG1773	rubredoxin
RG48_RS16495	COG1999	signal sequence binding
RG48_RS16500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG48_RS16505	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RG48_RS16510	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG48_RS16515	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG48_RS16525	COG0670	Belongs to the BI1 family
RG48_RS16530	COG2920	part of a sulfur-relay system
RG48_RS16535	COG1254	Belongs to the acylphosphatase family
RG48_RS16550	COG1832	CoA-binding protein
RG48_RS16570	COG0210	DNA helicase
RG48_RS16575	COG3304	Inner membrane component domain
RG48_RS16580	COG1289	transmembrane transporter activity
RG48_RS16585	COG3070	regulator of competence-specific genes
RG48_RS16600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG48_RS16600	COG2885	chlorophyll binding
RG48_RS16610	COG1067	ATP-dependent peptidase activity
RG48_RS16620	COG3130	regulation of translation
RG48_RS16625	COG3009	Protein conserved in bacteria
RG48_RS16630	COG3008	intermembrane lipid transfer
RG48_RS16630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG48_RS16635	COG2995	paraquat-inducible protein a
RG48_RS16640	COG0488	(ABC) transporter
RG48_RS16650	COG0633	Ferredoxin
RG48_RS16650	COG3217	Mosc domain protein beta barrel domain protein
RG48_RS16665	COG3121	Chaperone
RG48_RS16670	COG3539	Fimbrial protein
RG48_RS16675	COG3539	Fimbrial protein
RG48_RS16680	COG3539	Fimbrial protein
RG48_RS16685	COG3188	usher protein
RG48_RS16690	COG3121	Chaperone
RG48_RS16695	COG3539	Fimbrial protein
RG48_RS16705	COG0431	NADPH-dependent FMN reductase
RG48_RS16710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RG48_RS16720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG48_RS16725	COG1116	anion transmembrane transporter activity
RG48_RS16730	COG0308	aminopeptidase N
RG48_RS16755	COG1448	Aminotransferase
RG48_RS16760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RG48_RS16765	COG3108	Peptidase M15
RG48_RS16775	COG2989	Protein conserved in bacteria
RG48_RS16785	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RG48_RS16795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RG48_RS16800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG48_RS16805	COG3173	Aminoglycoside phosphotransferase
RG48_RS16820	COG3214	Protein conserved in bacteria
RG48_RS16830	COG1132	(ABC) transporter
RG48_RS16835	COG0658	competence protein
RG48_RS16835	COG2333	competence protein COMEC
RG48_RS16845	COG0539	negative regulation of cytoplasmic translation
RG48_RS16855	COG0501	Belongs to the peptidase M48B family
RG48_RS16870	COG2323	membrane
RG48_RS16875	COG1944	ATP diphosphatase activity
RG48_RS16880	COG2116	formate transmembrane transporter activity
RG48_RS16885	COG1882	Formate acetyltransferase
RG48_RS16910	COG4974	Belongs to the 'phage' integrase family
RG48_RS16915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG48_RS16920	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG48_RS16925	COG0583	DNA-binding transcription factor activity
RG48_RS16930	COG0583	DNA-binding transcription factor activity
RG48_RS16935	COG0531	amino acid
RG48_RS16945	COG1335	isochorismatase
RG48_RS16950	COG3302	dmso reductase anchor subunit
RG48_RS16955	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS16960	COG0243	molybdopterin cofactor binding
RG48_RS16970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RG48_RS16980	COG1178	ABC-type Fe3 transport system permease component
RG48_RS16980	COG1674	ftsk spoiiie
RG48_RS16985	COG1522	sequence-specific DNA binding
RG48_RS16995	COG0492	ferredoxin-NADP+ reductase activity
RG48_RS17000	COG4988	ABC transporter
RG48_RS17005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RG48_RS17030	COG0542	response to heat
RG48_RS17040	COG1278	Cold shock
RG48_RS17045	COG0577	efflux transmembrane transporter activity
RG48_RS17045	COG1136	(ABC) transporter
RG48_RS17050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS17055	COG2990	Protein conserved in bacteria
RG48_RS17060	COG3593	DNA synthesis involved in DNA repair
RG48_RS17080	COG2431	L-lysine efflux transmembrane transporter activity
RG48_RS17090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG48_RS17095	COG0028	Belongs to the TPP enzyme family
RG48_RS17100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RG48_RS17105	COG0702	epimerase
RG48_RS17110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG48_RS17115	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG48_RS17130	COG1126	abc transporter atp-binding protein
RG48_RS17135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS17140	COG4215	(ABC) transporter
RG48_RS17145	COG4160	amino acid transport
RG48_RS17150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS17170	COG1177	transmembrane transport
RG48_RS17175	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG48_RS17180	COG3842	ATPase activity
RG48_RS17185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG48_RS17205	COG0778	Nitroreductase
RG48_RS17215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG48_RS17265	COG4695	Portal protein
RG48_RS17300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG48_RS17340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RG48_RS17345	COG3226	Transcriptional regulator
RG48_RS17350	COG0738	Major facilitator superfamily
RG48_RS17355	COG0561	phosphatase activity
RG48_RS17365	COG2814	Major facilitator Superfamily
RG48_RS17370	COG0671	phosphoesterase, PA-phosphatase related
RG48_RS17375	COG1349	DNA-binding transcription factor activity
RG48_RS17380	COG1686	Belongs to the peptidase S11 family
RG48_RS17385	COG0625	glutathione transferase activity
RG48_RS17390	COG2133	pyrroloquinoline quinone binding
RG48_RS17405	COG2199	diguanylate cyclase activity
RG48_RS17410	COG2200	EAL domain
RG48_RS17425	COG0747	negative chemotaxis
RG48_RS17435	COG1446	asparaginase
RG48_RS17440	COG0303	'Molybdopterin
RG48_RS17445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG48_RS17450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG48_RS17455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG48_RS17460	COG1882	Formate acetyltransferase
RG48_RS17465	COG0561	phosphatase activity
RG48_RS17475	COG0488	(ABC) transporter
RG48_RS17480	COG1376	ErfK ybiS ycfS ynhG family protein
RG48_RS17485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG48_RS17490	COG1321	iron dependent repressor
RG48_RS17500	COG2194	sulfuric ester hydrolase activity
RG48_RS17505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG48_RS17510	COG5006	permease, DMT superfamily
RG48_RS17535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS17540	COG0765	amino acid transport
RG48_RS17545	COG1126	abc transporter atp-binding protein
RG48_RS17555	COG0668	transmembrane transport
RG48_RS17570	COG4774	siderophore transport
RG48_RS17580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG48_RS17590	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS17600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG48_RS17605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG48_RS17610	COG1199	ATP-dependent helicase activity
RG48_RS17620	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RG48_RS17625	COG0513	Belongs to the DEAD box helicase family
RG48_RS17630	COG1309	transcriptional regulator
RG48_RS17640	COG1131	(ABC) transporter
RG48_RS17645	COG0842	Transport permease protein
RG48_RS17650	COG0842	Transport permease protein
RG48_RS17660	COG3568	Endonuclease Exonuclease Phosphatase
RG48_RS17665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG48_RS17670	COG0392	lysyltransferase activity
RG48_RS17675	COG0670	Belongs to the BI1 family
RG48_RS17680	COG0670	Belongs to the BI1 family
RG48_RS17685	COG0314	molybdopterin synthase activity
RG48_RS17690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RG48_RS17700	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG48_RS17710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RG48_RS17720	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG48_RS17725	COG2226	methyltransferase
RG48_RS17740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RG48_RS17745	COG1881	PFAM PEBP family protein
RG48_RS17755	COG2199	diguanylate cyclase activity
RG48_RS17760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG48_RS17765	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG48_RS17775	COG5562	phage envelope protein
RG48_RS17795	COG3772	lysozyme
RG48_RS17805	COG2207	Transcriptional regulator
RG48_RS17815	COG3272	Protein of unknown function (DUF1722)
RG48_RS17940	COG0582	viral genome integration into host DNA
RG48_RS17945	COG4677	pectinesterase activity
RG48_RS17950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG48_RS17955	COG0471	metal ion transport
RG48_RS17960	COG2828	Protein conserved in bacteria
RG48_RS17965	COG0583	DNA-binding transcription factor activity
RG48_RS17975	COG0561	phosphatase activity
RG48_RS17980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RG48_RS17985	COG4149	molybdate abc transporter
RG48_RS17990	COG0725	ABC transporter, periplasmic molybdate-binding protein
RG48_RS18005	COG3585	molybdate ion transport
RG48_RS18005	COG2005	Transcriptional regulator
RG48_RS18010	COG1119	ATPase activity
RG48_RS18015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RG48_RS18020	COG1085	galactose-1-phosphate uridylyltransferase
RG48_RS18030	COG2017	converts alpha-aldose to the beta-anomer
RG48_RS18040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG48_RS18055	COG1230	cation diffusion facilitator family transporter
RG48_RS18060	COG3201	nicotinamide mononucleotide transporter
RG48_RS18105	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RG48_RS18110	COG2885	chlorophyll binding
RG48_RS18120	COG3064	Membrane
RG48_RS18125	COG0848	biopolymer transport protein
RG48_RS18130	COG0811	peptide transport
RG48_RS18135	COG0824	Thioesterase
RG48_RS18140	COG3790	cyd operon protein YbgE
RG48_RS18145	COG4890	Cyd operon protein YbgT
RG48_RS18150	COG1294	oxidase, subunit
RG48_RS18155	COG1271	oxidase subunit
RG48_RS18165	COG0383	alpha-mannosidase activity
RG48_RS18170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS18170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS18170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS18175	COG2188	Transcriptional regulator
RG48_RS18180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG48_RS18190	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG48_RS18195	COG0567	Dehydrogenase, E1 component
RG48_RS18205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG48_RS18210	COG1053	succinate dehydrogenase
RG48_RS18215	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RG48_RS18220	COG2009	succinate dehydrogenase
RG48_RS18240	COG0372	Belongs to the citrate synthase family
RG48_RS18245	COG3539	Fimbrial protein
RG48_RS18250	COG3188	usher protein
RG48_RS18255	COG3121	Chaperone
RG48_RS18260	COG3539	Fimbrial protein
RG48_RS18265	COG3180	Ammonia monooxygenase
RG48_RS18280	COG1984	allophanate hydrolase subunit 2
RG48_RS18285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RG48_RS18290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RG48_RS18295	COG3104	oligopeptide transport
RG48_RS18300	COG0415	Belongs to the DNA photolyase family
RG48_RS18305	COG3272	Protein of unknown function (DUF1722)
RG48_RS18310	COG5433	transposase activity
RG48_RS18315	COG5433	transposase activity
RG48_RS18325	COG3209	COG3209 Rhs family protein
RG48_RS18335	COG3209	COG3209 Rhs family protein
RG48_RS18340	COG3209	COG3209 Rhs family protein
RG48_RS18345	COG2963	transposase activity
RG48_RS18350	COG2801	Transposase and inactivated derivatives
RG48_RS18355	COG3209	COG3209 Rhs family protein
RG48_RS18385	COG2205	protein histidine kinase activity
RG48_RS18390	COG0745	RESPONSE REGULATOR receiver
RG48_RS18405	COG1982	Orn Lys Arg decarboxylase major
RG48_RS18410	COG0531	amino acid
RG48_RS18430	COG0033	Phosphoglucomutase
RG48_RS18435	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RG48_RS18440	COG0596	Alpha beta hydrolase
RG48_RS18450	COG0716	FMN binding
RG48_RS18465	COG0735	belongs to the Fur family
RG48_RS18485	COG1263	PTS System
RG48_RS18485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS18485	COG2190	(PTS) system
RG48_RS18495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG48_RS18500	COG1846	Transcriptional regulator
RG48_RS18500	COG1940	carbohydrate kinase activity
RG48_RS18505	COG0647	UMP catabolic process
RG48_RS18510	COG0367	asparagine synthase
RG48_RS18560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG48_RS18570	COG1702	phosphate starvation-inducible protein PhoH
RG48_RS18580	COG4535	Mg2 and Co2 transporter CorC
RG48_RS18585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RG48_RS18600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG48_RS18605	COG0765	amino acid transport
RG48_RS18610	COG0765	amino acid transport
RG48_RS18615	COG1126	abc transporter atp-binding protein
RG48_RS18625	COG0443	Heat shock 70 kDa protein
RG48_RS18635	COG2214	Heat shock protein DnaJ domain protein
RG48_RS18645	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG48_RS18650	COG2214	Heat shock protein DnaJ domain protein
RG48_RS18660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG48_RS18665	COG2888	peptidyl-tyrosine sulfation
RG48_RS18680	COG1466	dna polymerase III delta subunit
RG48_RS18690	COG0406	alpha-ribazole phosphatase activity
RG48_RS18695	COG0799	negative regulation of ribosome biogenesis
RG48_RS18705	COG0768	penicillin binding
RG48_RS18710	COG0772	Belongs to the SEDS family
RG48_RS18715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG48_RS18720	COG1686	Belongs to the peptidase S11 family
RG48_RS18740	COG0583	DNA-binding transcription factor activity
RG48_RS18755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG48_RS18760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG48_RS18785	COG3069	C4-dicarboxylate transmembrane transporter activity
RG48_RS18790	COG4565	transcriptional regulatory protein
RG48_RS18795	COG3290	protein histidine kinase activity
RG48_RS18800	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RG48_RS18810	COG2301	Belongs to the HpcH HpaI aldolase family
RG48_RS18815	COG3051	citrate lyase alpha subunit
RG48_RS18830	COG0471	metal ion transport
RG48_RS18835	COG3719	Belongs to the RNase T2 family
RG48_RS18845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG48_RS18855	COG1063	alcohol dehydrogenase
RG48_RS18860	COG0589	response to stress
RG48_RS18865	COG3634	alkyl hydroperoxide reductase activity
RG48_RS18870	COG0450	alkyl hydroperoxide reductase
RG48_RS18875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG48_RS18885	COG0583	DNA-binding transcription factor activity
RG48_RS18890	COG3969	phosphoadenosine phosphosulfate
RG48_RS18895	COG1475	DNA binding
RG48_RS18900	COG0436	Aminotransferase
RG48_RS18905	COG0371	Dehydrogenase
RG48_RS18910	COG2879	small protein
RG48_RS18915	COG1966	Carbon starvation protein
RG48_RS18920	COG2050	protein possibly involved in aromatic compounds catabolism
RG48_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS18930	COG1535	isochorismatase
RG48_RS18930	COG3433	isochorismatase activity
RG48_RS18935	COG1021	2,3-dihydroxybenzoate-AMP ligase
RG48_RS18940	COG1169	isochorismate synthase
RG48_RS18950	COG4592	Periplasmic binding protein
RG48_RS18960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG48_RS18965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG48_RS18970	COG1120	ATPase activity
RG48_RS18975	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG48_RS18980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG48_RS18980	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RG48_RS18985	COG3251	PFAM MbtH domain protein
RG48_RS18990	COG2382	esterase
RG48_RS18995	COG4771	TonB-dependent receptor
RG48_RS19005	COG2977	Belongs to the P-Pant transferase superfamily
RG48_RS19015	COG3385	transposase activity
RG48_RS19025	COG2801	Transposase and inactivated derivatives
RG48_RS19030	COG2963	transposase activity
RG48_RS19050	COG2315	Protein conserved in bacteria
RG48_RS19055	COG0778	Nitroreductase
RG48_RS19060	COG0668	transmembrane transport
RG48_RS19065	COG1113	amino acid transport
RG48_RS19070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG48_RS19075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS19080	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS19085	COG1538	Outer membrane efflux protein
RG48_RS19095	COG0745	RESPONSE REGULATOR receiver
RG48_RS19100	COG5002	protein histidine kinase activity
RG48_RS19110	COG3501	Rhs element vgr protein
RG48_RS19120	COG4104	PAAR repeat-containing protein
RG48_RS19120	COG3209	COG3209 Rhs family protein
RG48_RS19145	COG5433	transposase activity
RG48_RS19155	COG4783	chaperone-mediated protein folding
RG48_RS19170	COG2207	Transcriptional regulator
RG48_RS19180	COG2197	response regulator
RG48_RS19185	COG3539	Fimbrial protein
RG48_RS19190	COG3539	Fimbrial protein
RG48_RS19195	COG3188	usher protein
RG48_RS19200	COG3121	Chaperone
RG48_RS19205	COG3539	Fimbrial protein
RG48_RS19215	COG2501	S4 domain
RG48_RS19220	COG1988	membrane-bound metal-dependent
RG48_RS19230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG48_RS19245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RG48_RS19250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RG48_RS19255	COG0549	Belongs to the carbamate kinase family
RG48_RS19270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG48_RS19275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG48_RS19280	COG3257	ureidoglycine aminohydrolase activity
RG48_RS19285	COG1929	Belongs to the glycerate kinase type-1 family
RG48_RS19290	COG2233	PERMEase
RG48_RS19300	COG1953	Uracil, thiamine, allantoin
RG48_RS19305	COG2084	Dehydrogenase
RG48_RS19310	COG3622	Belongs to the hyi family
RG48_RS19315	COG3960	tartronate-semialdehyde synthase activity
RG48_RS19320	COG1414	Transcriptional regulator
RG48_RS19330	COG0583	DNA-binding transcription factor activity
RG48_RS19345	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS19350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RG48_RS19355	COG4181	ATPase activity
RG48_RS19360	COG2755	lipolytic protein G-D-S-L family
RG48_RS19365	COG0300	oxidoreductase activity
RG48_RS19370	COG3118	belongs to the thioredoxin family
RG48_RS19375	COG0390	transport system, permease component
RG48_RS19380	COG4619	ABC transporter
RG48_RS19385	COG0330	HflC and HflK could
RG48_RS19390	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG48_RS19395	COG0789	Transcriptional regulator
RG48_RS19405	COG0531	amino acid
RG48_RS19415	COG2217	Heavy metal translocating P-type atpase
RG48_RS19425	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS19435	COG3093	addiction module antidote protein HigA
RG48_RS19440	COG3735	TraB family
RG48_RS19445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG48_RS19450	COG0737	Belongs to the 5'-nucleotidase family
RG48_RS19460	COG2223	nitrite transmembrane transporter activity
RG48_RS19465	COG4651	solute:proton antiporter activity
RG48_RS19465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG48_RS19470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS19505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RG48_RS19520	COG2832	Protein of unknown function (DUF454)
RG48_RS19525	COG3923	Primosomal replication protein n
RG48_RS19535	COG3264	Mechanosensitive ion channel
RG48_RS19535	COG1196	nuclear chromosome segregation
RG48_RS19545	COG1309	transcriptional regulator
RG48_RS19550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG48_RS19555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG48_RS19570	COG0110	maltose O-acetyltransferase activity
RG48_RS19580	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG48_RS19585	COG5507	3-demethylubiquinone-9 3-methyltransferase
RG48_RS19595	COG3695	enzyme binding
RG48_RS19600	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RG48_RS19605	COG1946	Acyl-CoA thioesterase
RG48_RS19610	COG0004	ammonium transporteR
RG48_RS19615	COG0347	Belongs to the P(II) protein family
RG48_RS19620	COG1132	(ABC) transporter
RG48_RS19625	COG1132	(ABC) transporter
RG48_RS19630	COG1522	sequence-specific DNA binding
RG48_RS19640	COG4533	DNA binding
RG48_RS19650	COG0824	Thioesterase
RG48_RS19655	COG1555	photosystem II stabilization
RG48_RS19660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG48_RS19665	COG0776	regulation of translation
RG48_RS19670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RG48_RS19695	COG0271	Belongs to the BolA IbaG family
RG48_RS19705	COG3056	Lipoprotein
RG48_RS19710	COG2223	nitrite transmembrane transporter activity
RG48_RS19715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RG48_RS19720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RG48_RS19725	COG1845	cytochrome c oxidase, subunit III
RG48_RS19730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RG48_RS19740	COG2814	Major facilitator Superfamily
RG48_RS19750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RG48_RS19755	COG0693	protein deglycase activity
RG48_RS19770	COG0142	geranyltranstransferase activity
RG48_RS19780	COG0667	Aldo Keto reductase
RG48_RS19785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RG48_RS19790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RG48_RS19805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG48_RS19805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG48_RS19815	COG4238	major outer membrane lipoprotein
RG48_RS19820	COG3248	Nucleoside-binding outer membrane protein
RG48_RS19825	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS19830	COG1403	HNH endonuclease
RG48_RS19835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG48_RS19840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG48_RS19845	COG1862	Preprotein translocase
RG48_RS19865	COG0366	Alpha amylase catalytic
RG48_RS19870	COG1113	amino acid transport
RG48_RS19875	COG1114	Component of the transport system for branched-chain amino acids
RG48_RS19880	COG5002	protein histidine kinase activity
RG48_RS19885	COG0745	RESPONSE REGULATOR receiver
RG48_RS19890	COG0420	3'-5' exonuclease activity
RG48_RS19895	COG0419	ATPase involved in DNA repair
RG48_RS19900	COG2814	Major facilitator Superfamily
RG48_RS19905	COG1940	carbohydrate kinase activity
RG48_RS19930	COG4126	flavin adenine dinucleotide binding
RG48_RS19955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RG48_RS19960	COG3706	GGDEF domain
RG48_RS19970	COG1785	Belongs to the alkaline phosphatase family
RG48_RS19985	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG48_RS20005	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RG48_RS20015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG48_RS20020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG48_RS20025	COG3468	outer membrane autotransporter barrel domain protein
RG48_RS20035	COG0113	porphobilinogen synthase activity
RG48_RS20040	COG2175	clavaminate synthase activity
RG48_RS20045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG48_RS20055	COG4521	taurine ABC transporter
RG48_RS20065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RG48_RS20100	COG3122	Protein conserved in bacteria
RG48_RS20105	COG2814	Major facilitator Superfamily
RG48_RS20125	COG3971	2-oxopent-4-enoate hydratase activity
RG48_RS20145	COG1414	Transcriptional regulator
RG48_RS20150	COG1609	Transcriptional regulator
RG48_RS20160	COG3250	beta-galactosidase activity
RG48_RS20165	COG2223	nitrite transmembrane transporter activity
RG48_RS20170	COG0110	maltose O-acetyltransferase activity
RG48_RS20175	COG2807	transmembrane transport
RG48_RS20185	COG0288	reversible hydration of carbon dioxide
RG48_RS20190	COG0583	DNA-binding transcription factor activity
RG48_RS20195	COG0402	S-adenosylhomocysteine deaminase activity
RG48_RS20200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RG48_RS20205	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS20220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG48_RS20225	COG2079	MmgE PrpD family protein
RG48_RS20230	COG0372	Belongs to the citrate synthase family
RG48_RS20240	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RG48_RS20245	COG3829	transcription factor binding
RG48_RS20255	COG1280	lysine exporter protein (LysE YggA)
RG48_RS20270	COG1064	alcohol dehydrogenase
RG48_RS20275	COG0402	S-adenosylhomocysteine deaminase activity
RG48_RS20280	COG0549	Belongs to the carbamate kinase family
RG48_RS20290	COG1304	FMN binding
RG48_RS20295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG48_RS20305	COG0666	response to abiotic stimulus
RG48_RS20320	COG0583	DNA-binding transcription factor activity
RG48_RS20325	COG2771	luxR family
RG48_RS20325	COG2200	EAL domain
RG48_RS20340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG48_RS20380	COG1556	Lactate utilization protein
RG48_RS20385	COG1139	Iron-sulfur cluster binding protein
RG48_RS20390	COG0247	lactate metabolic process
RG48_RS20395	COG2207	Transcriptional regulator
RG48_RS20400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG48_RS20410	COG3059	membrane
RG48_RS20415	COG2207	Transcriptional regulator
RG48_RS20415	COG3708	Transcriptional regulator
RG48_RS20420	COG1388	LysM domain
RG48_RS20470	COG3188	usher protein
RG48_RS20480	COG3121	Chaperone
RG48_RS20485	COG0727	PFAM Uncharacterised protein family (UPF0153)
RG48_RS20495	COG3477	response to acidic pH
RG48_RS20505	COG2080	2 iron, 2 sulfur cluster binding
RG48_RS20510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG48_RS20515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG48_RS20520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG48_RS20525	COG0583	DNA-binding transcription factor activity
RG48_RS20535	COG2207	Transcriptional regulator
RG48_RS20565	COG3698	Phosphodiester glycosidase
RG48_RS20575	COG0598	Magnesium transport protein CorA
RG48_RS20650	COG3344	reverse transcriptase
RG48_RS20690	COG3039	Transposase
RG48_RS20695	COG3596	GTP binding
RG48_RS20705	COG2378	regulation of single-species biofilm formation
RG48_RS20715	COG2378	regulation of single-species biofilm formation
RG48_RS20725	COG2801	Transposase and inactivated derivatives
RG48_RS20770	COG3596	GTP binding
RG48_RS20790	COG2378	regulation of single-species biofilm formation
RG48_RS20805	COG2003	Belongs to the UPF0758 family
RG48_RS20840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG48_RS20860	COG2195	Cleaves the N-terminal amino acid of tripeptides
RG48_RS20865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG48_RS20870	COG1690	Belongs to the RtcB family
RG48_RS20875	COG0454	-acetyltransferase
RG48_RS20885	COG2161	toxin-antitoxin pair type II binding
RG48_RS20915	COG1943	Transposase
RG48_RS20920	COG0791	NLP P60 protein
RG48_RS20925	COG3034	peptidoglycan biosynthetic process
RG48_RS20930	COG0121	glutamine amidotransferase
RG48_RS20940	COG1960	acyl-CoA dehydrogenase activity
RG48_RS20950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG48_RS20965	COG3209	COG3209 Rhs family protein
RG48_RS21005	COG3157	Type VI secretion system effector, Hcp
RG48_RS21010	COG4104	PAAR repeat-containing protein
RG48_RS21030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG48_RS21040	COG2226	methyltransferase
RG48_RS21050	COG1388	LysM domain
RG48_RS21050	COG0741	lytic transglycosylase activity
RG48_RS21055	COG2226	methyltransferase
RG48_RS21065	COG0583	DNA-binding transcription factor activity
RG48_RS21070	COG0656	L-ascorbic acid biosynthetic process
RG48_RS21100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG48_RS21105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RG48_RS21110	COG2011	ABC-type metal ion transport system permease component
RG48_RS21115	COG1464	Belongs to the NlpA lipoprotein family
RG48_RS21125	COG1720	tRNA m6t6A37 methyltransferase activity
RG48_RS21140	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS21145	COG3015	lipoprotein NlpE involved in copper resistance
RG48_RS21150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG48_RS21155	COG4681	YaeQ
RG48_RS21165	COG4568	rho-dependent transcription termination
RG48_RS21175	COG0346	lactoylglutathione lyase activity
RG48_RS21190	COG0587	DNA-directed DNA polymerase activity
RG48_RS21215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RG48_RS21220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RG48_RS21230	COG0750	zinc metalloprotease
RG48_RS21235	COG0575	Belongs to the CDS family
RG48_RS21240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RG48_RS21245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RG48_RS21280	COG0024	Methionine aminopeptidase
RG48_RS21300	COG3835	regulator
RG48_RS21305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG48_RS21325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG48_RS21330	COG2860	membrane
RG48_RS21350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG48_RS21355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG48_RS21360	COG1120	ATPase activity
RG48_RS21365	COG4774	siderophore transport
RG48_RS21370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RG48_RS21380	COG1643	Atp-dependent helicase
RG48_RS21385	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RG48_RS21395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG48_RS21405	COG0617	tRNA 3'-terminal CCA addition
RG48_RS21410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RG48_RS21415	COG3539	Fimbrial protein
RG48_RS21420	COG3121	Chaperone
RG48_RS21425	COG3188	usher protein
RG48_RS21430	COG3539	Fimbrial protein
RG48_RS21435	COG3539	Fimbrial protein
RG48_RS21440	COG3539	Fimbrial protein
RG48_RS21445	COG3539	Fimbrial protein
RG48_RS21460	COG5464	transposase or invertase
RG48_RS21480	COG0726	polysaccharide deacetylase
RG48_RS21485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS21490	COG0842	Transport permease protein
RG48_RS21495	COG1131	(ABC) transporter
RG48_RS21500	COG0288	reversible hydration of carbon dioxide
RG48_RS21505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RG48_RS21510	COG4993	Dehydrogenase
RG48_RS21515	COG2132	Multicopper oxidase
RG48_RS21540	COG1049	propionate catabolic process, 2-methylcitrate cycle
RG48_RS21555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG48_RS21560	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG48_RS21565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RG48_RS21575	COG2186	Transcriptional regulator
RG48_RS21580	COG1113	amino acid transport
RG48_RS21585	COG3725	Membrane protein required for beta-lactamase induction
RG48_RS21590	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG48_RS21595	COG0157	Belongs to the NadC ModD family
RG48_RS21605	COG4969	Belongs to the N-Me-Phe pilin family
RG48_RS21610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG48_RS21615	COG1459	type II secretion system
RG48_RS21625	COG0237	dephospho-CoA kinase activity
RG48_RS21640	COG0494	nUDIX hydrolase
RG48_RS21660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RG48_RS21665	COG0849	cell division
RG48_RS21670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RG48_RS21675	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG48_RS21690	COG0772	Belongs to the SEDS family
RG48_RS21705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RG48_RS21710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG48_RS21715	COG0768	penicillin binding
RG48_RS21720	COG3116	cell division
RG48_RS21740	COG1609	Transcriptional regulator
RG48_RS21750	COG0440	acetolactate synthase activity
RG48_RS21755	COG0028	Belongs to the TPP enzyme family
RG48_RS21760	COG0583	DNA-binding transcription factor activity
RG48_RS21775	COG0473	3-isopropylmalate dehydrogenase activity
RG48_RS21790	COG2814	Major facilitator Superfamily
RG48_RS21805	COG4143	(ABC) transporter
RG48_RS21810	COG1178	ABC-type Fe3 transport system permease component
RG48_RS21820	COG0586	Pfam SNARE associated Golgi protein
RG48_RS21825	COG4977	sequence-specific DNA binding
RG48_RS21845	COG0235	Class ii aldolase
RG48_RS21850	COG0417	DNA replication proofreading
RG48_RS21860	COG0564	pseudouridine synthase activity
RG48_RS21865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RG48_RS21870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG48_RS21875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG48_RS21915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RG48_RS21935	COG2271	Major facilitator Superfamily
RG48_RS21945	COG0644	oxidoreductase
RG48_RS22000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RG48_RS22005	COG0505	Belongs to the CarA family
RG48_RS22025	COG1047	Peptidyl-prolyl cis-trans
RG48_RS22040	COG0196	riboflavin kinase activity
RG48_RS22060	COG3188	usher protein
RG48_RS22070	COG0583	DNA-binding transcription factor activity
RG48_RS22100	COG4735	regulation of single-species biofilm formation
RG48_RS22105	COG1584	GPR1 FUN34 yaaH family protein
RG48_RS22110	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG48_RS22120	COG1115	amino acid carrier protein
RG48_RS22130	COG3547	Transposase (IS116 IS110 IS902 family)
RG48_RS22145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RG48_RS22155	COG0460	homoserine dehydrogenase
RG48_RS22155	COG0527	aspartate kinase activity
RG48_RS22165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RG48_RS22175	COG0745	RESPONSE REGULATOR receiver
RG48_RS22180	COG4452	Inner membrane protein CreD
RG48_RS22185	COG2205	protein histidine kinase activity
RG48_RS22190	COG0745	RESPONSE REGULATOR receiver
RG48_RS22195	COG3045	CreA protein
RG48_RS22200	COG3708	Transcriptional regulator
RG48_RS22200	COG2207	Transcriptional regulator
RG48_RS22220	COG0741	lytic transglycosylase activity
RG48_RS22230	COG0488	(ABC) transporter
RG48_RS22240	COG1056	cytidyltransferase-related domain
RG48_RS22240	COG3172	ATPase kinase involved in NAD metabolism
RG48_RS22245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RG48_RS22250	COG0560	Phosphoserine phosphatase
RG48_RS22255	COG3726	membrane protein affecting hemolysin expression
RG48_RS22295	COG1328	CTP reductase activity
RG48_RS22300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG48_RS22305	COG0084	hydrolase, TatD family'
RG48_RS22310	COG4667	esterase of the alpha-beta hydrolase superfamily
RG48_RS22320	COG2823	Periplasmic or secreted lipoprotein
RG48_RS22330	COG1011	Hydrolase
RG48_RS22335	COG0456	acetyltransferase
RG48_RS22340	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
RG48_RS22375	COG4114	ferric iron reductase
RG48_RS22380	COG2197	response regulator
RG48_RS22385	COG2197	response regulator
RG48_RS22390	COG2966	Psort location CytoplasmicMembrane, score
RG48_RS22405	COG1484	DNA-dependent DNA replication
RG48_RS22420	COG1063	alcohol dehydrogenase
RG48_RS22425	COG1802	Transcriptional regulator
RG48_RS22430	COG2271	Major facilitator Superfamily
RG48_RS22435	COG0840	transmembrane signaling receptor activity
RG48_RS22440	COG1846	Transcriptional regulator
RG48_RS22445	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG48_RS22450	COG1012	belongs to the aldehyde dehydrogenase family
RG48_RS22455	COG3384	dioxygenase
RG48_RS22465	COG3971	2-oxopent-4-enoate hydratase activity
RG48_RS22485	COG2368	4-hydroxyphenylacetate
RG48_RS22490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG48_RS22495	COG1966	Carbon starvation protein
RG48_RS22500	COG2879	small protein
RG48_RS22505	COG0523	cobalamin synthesis protein
RG48_RS22515	COG5457	Domain of unknown function (DUF1127)
RG48_RS22520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG48_RS22530	COG2814	Major facilitator Superfamily
RG48_RS22535	COG2733	membrane
RG48_RS22540	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RG48_RS22545	COG1924	4 iron, 4 sulfur cluster binding
RG48_RS22560	COG0477	Major facilitator Superfamily
RG48_RS22575	COG3366	ferrous iron transmembrane transporter activity
RG48_RS22580	COG0700	Nucleoside recognition
RG48_RS22585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG48_RS22590	COG0583	DNA-binding transcription factor activity
RG48_RS22610	COG2186	Transcriptional regulator
RG48_RS22620	COG0246	Mannitol dehydrogenase
RG48_RS22635	COG2610	gluconate transmembrane transporter activity
RG48_RS22640	COG3539	Fimbrial protein
RG48_RS22645	COG3539	Fimbrial protein
RG48_RS22650	COG3539	Fimbrial protein
RG48_RS22655	COG3188	usher protein
RG48_RS22660	COG3121	Chaperone
RG48_RS22665	COG3539	Fimbrial protein
RG48_RS22680	COG4974	Belongs to the 'phage' integrase family
RG48_RS22685	COG0582	viral genome integration into host DNA
RG48_RS22695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG48_RS22780	COG0582	viral genome integration into host DNA
RG48_RS22790	COG1064	alcohol dehydrogenase
RG48_RS22795	COG0433	COG0433 Predicted ATPase
RG48_RS22800	COG0795	lipopolysaccharide-transporting ATPase activity
RG48_RS22805	COG0795	lipopolysaccharide-transporting ATPase activity
RG48_RS22815	COG2927	DNA polymerase III (CHI subunit)
RG48_RS22820	COG0525	valine-tRNA ligase activity
RG48_RS22825	COG4269	membrane
RG48_RS22830	COG0456	acetyltransferase
RG48_RS22835	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
RG48_RS22850	COG2731	YhcH YjgK YiaL family protein
RG48_RS22855	COG1309	transcriptional regulator
RG48_RS22860	COG1028	Short-chain dehydrogenase reductase Sdr
RG48_RS22865	COG0251	oxidation-reduction process
RG48_RS22890	COG0251	oxidation-reduction process
RG48_RS22900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RG48_RS22905	COG1609	Transcriptional regulator
RG48_RS22910	COG1263	PTS System
RG48_RS22910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG48_RS22915	COG0366	Alpha amylase catalytic
RG48_RS22920	COG1328	CTP reductase activity
RG48_RS22930	COG0602	queuosine metabolic process
RG48_RS22935	COG3783	Cytochrome b(562)
RG48_RS22940	COG0312	modulator of DNA gyrase
RG48_RS22950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RG48_RS22960	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG48_RS22965	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG48_RS22970	COG1129	ABC transporter
RG48_RS22975	COG1879	ABC-type sugar transport system periplasmic component
RG48_RS22980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RG48_RS22985	COG2105	PFAM AIG2 family protein
RG48_RS22990	COG2911	Protein conserved in bacteria
RG48_RS22995	COG0729	surface antigen
RG48_RS23010	COG1253	flavin adenine dinucleotide binding
RG48_RS23020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG48_RS23025	COG1218	3'(2'),5'-bisphosphate nucleotidase
RG48_RS23030	COG0737	Belongs to the 5'-nucleotidase family
RG48_RS23035	COG1733	regulation of RNA biosynthetic process
RG48_RS23040	COG0702	epimerase
RG48_RS23045	COG0697	spore germination
RG48_RS23055	COG1113	amino acid transport
RG48_RS23060	COG0545	Peptidyl-prolyl cis-trans isomerase
RG48_RS23070	COG3061	Opacity-associated protein A
RG48_RS23075	COG1309	transcriptional regulator
RG48_RS23080	COG0675	Transposase, IS605 OrfB family
RG48_RS23100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RG48_RS23120	COG3477	response to acidic pH
RG48_RS23140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS23145	COG3414	Phosphotransferase system galactitol-specific IIB component
RG48_RS23150	COG3037	sugar-specific permease SgaT UlaA
RG48_RS23165	COG1073	alpha beta
RG48_RS23170	COG3650	response to hydrogen peroxide
RG48_RS23180	COG1960	acyl-CoA dehydrogenase activity
RG48_RS23185	COG0754	glutathionylspermidine amidase activity
RG48_RS23190	COG5463	Belongs to the UPF0441 family
RG48_RS23195	COG3766	membrane
RG48_RS23205	COG1842	Phage shock protein A
RG48_RS23210	COG3789	protein conserved in bacteria
RG48_RS23220	COG2271	Major facilitator Superfamily
RG48_RS23225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RG48_RS23230	COG1414	Transcriptional regulator
RG48_RS23235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG48_RS23240	COG0557	exoribonuclease II activity
RG48_RS23255	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RG48_RS23260	COG0330	HflC and HflK could
RG48_RS23265	COG0330	HflC and HflK could
RG48_RS23270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RG48_RS23290	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG48_RS23295	COG0802	atpase or kinase
RG48_RS23300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RG48_RS23300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RG48_RS23305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG48_RS23340	COG1511	domain protein
RG48_RS23340	COG3264	Mechanosensitive ion channel
RG48_RS23355	COG0531	amino acid
RG48_RS23365	COG1053	succinate dehydrogenase
RG48_RS23370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG48_RS23385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG48_RS23390	COG3040	lipid binding
RG48_RS23395	COG2076	Multidrug Resistance protein
RG48_RS23400	COG5510	response to toxic substance
RG48_RS23405	COG5510	response to toxic substance
RG48_RS23415	COG1509	lysine 2,3-aminomutase activity
RG48_RS23440	COG0531	amino acid
RG48_RS23445	COG3030	protein affecting phage T7 exclusion by the F plasmid
RG48_RS23455	COG1027	Aspartate ammonia-lyase
RG48_RS23460	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG48_RS23470	COG4232	protein-disulfide reductase activity
RG48_RS23475	COG1309	transcriptional regulator
RG48_RS23490	COG3710	Transcriptional regulator
RG48_RS23500	COG0531	amino acid
RG48_RS23505	COG1982	Orn Lys Arg decarboxylase major
RG48_RS23510	COG3104	oligopeptide transport
RG48_RS23515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG48_RS23535	COG2388	GCN5-related N-acetyl-transferase
RG48_RS23540	COG3592	Divergent 4Fe-4S mono-cluster
RG48_RS23545	COG3290	protein histidine kinase activity
RG48_RS23550	COG4565	transcriptional regulatory protein
RG48_RS23560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG48_RS23565	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG48_RS23565	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG48_RS23570	COG3647	Membrane
RG48_RS23575	COG2211	Major facilitator Superfamily
RG48_RS23580	COG1486	melibiose metabolic process
RG48_RS23590	COG2169	Transcriptional regulator
RG48_RS23595	COG1982	Orn Lys Arg decarboxylase major
RG48_RS23600	COG2207	Transcriptional regulator
RG48_RS23605	COG0531	amino acid
RG48_RS23610	COG2194	sulfuric ester hydrolase activity
RG48_RS23615	COG0745	RESPONSE REGULATOR receiver
RG48_RS23620	COG0642	Histidine kinase
RG48_RS23630	COG0477	Major facilitator Superfamily
RG48_RS23650	COG2824	Alkylphosphonate utilization operon protein PhnA
RG48_RS23655	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RG48_RS23665	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RG48_RS23675	COG3639	organic phosphonate transmembrane transporter activity
RG48_RS23680	COG2188	Transcriptional regulator
RG48_RS23685	COG3624	Phosphonate C-P lyase system protein PhnG
RG48_RS23690	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RG48_RS23695	COG3626	phosphonate metabolism
RG48_RS23700	COG3627	carbon phosphorus lyase activity
RG48_RS23705	COG4107	phosphonate C-P lyase system protein PhnK
RG48_RS23710	COG4778	phosphonate C-P lyase system protein PhnL
RG48_RS23715	COG3454	Phosphonate metabolism
RG48_RS23720	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RG48_RS23725	COG0456	acetyltransferase
RG48_RS23730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RG48_RS23740	COG0698	ribose 5-phosphate isomerase
RG48_RS23745	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RG48_RS23755	COG1566	PFAM secretion protein HlyD family protein
RG48_RS23760	COG1289	transmembrane transporter activity
RG48_RS23770	COG3383	formate dehydrogenase (NAD+) activity
RG48_RS23775	COG3383	formate dehydrogenase (NAD+) activity
RG48_RS23780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG48_RS23785	COG1301	dicarboxylic acid transport
RG48_RS23795	COG4235	cytochrome complex assembly
RG48_RS23800	COG3088	subunit of a heme lyase
RG48_RS23805	COG1138	Cytochrome C-type biogenesis protein
RG48_RS23810	COG3301	Polysulphide reductase, NrfD
RG48_RS23815	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS23820	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RG48_RS23835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG48_RS23840	COG3162	membrane
RG48_RS23855	COG0025	NhaP-type Na H and K H
RG48_RS23860	COG2252	PERMEase
RG48_RS23880	COG0789	Transcriptional regulator
RG48_RS23885	COG2207	Transcriptional regulator
RG48_RS23890	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG48_RS23905	COG0629	single-stranded DNA binding
RG48_RS23910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RG48_RS23915	COG2315	Protein conserved in bacteria
RG48_RS23920	COG0432	Pfam Uncharacterised protein family UPF0047
RG48_RS23925	COG3700	Belongs to the class B bacterial acid phosphatase family
RG48_RS23935	COG1448	Aminotransferase
RG48_RS23940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG48_RS23945	COG0305	Participates in initiation and elongation during chromosome replication
RG48_RS23950	COG0604	alcohol dehydrogenase
RG48_RS23960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG48_RS23975	COG0735	belongs to the Fur family
RG48_RS23980	COG3237	CsbD-like
RG48_RS23985	COG0534	Mate efflux family protein
RG48_RS23995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RG48_RS24025	COG1357	PFAM Pentapeptide repeats (8 copies)
RG48_RS24045	COG3842	ATPase activity
RG48_RS24055	COG2182	Extracellular solute-binding protein
RG48_RS24060	COG1175	transmembrane transport
RG48_RS24065	COG3833	ABC-type maltose transport systems, permease component
RG48_RS24070	COG0477	Major facilitator Superfamily
RG48_RS24070	COG2814	Major facilitator Superfamily
RG48_RS24085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG48_RS24115	COG0527	aspartate kinase activity
RG48_RS24120	COG0542	response to heat
RG48_RS24125	COG3541	Predicted nucleotidyltransferase
RG48_RS24140	COG1187	pseudouridine synthase activity
RG48_RS24150	COG1283	sodium-dependent phosphate transmembrane transporter activity
RG48_RS24155	COG1410	methionine synthase
RG48_RS24155	COG0646	methionine synthase
RG48_RS24160	COG1414	Transcriptional regulator
RG48_RS24180	COG2224	Isocitrate lyase
RG48_RS24185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG48_RS24195	COG0456	acetyltransferase
RG48_RS24230	COG0151	Belongs to the GarS family
RG48_RS24235	COG2204	response regulator
RG48_RS24240	COG4191	Histidine kinase
RG48_RS24250	COG3678	ATP-independent chaperone mediated protein folding
RG48_RS24265	COG3068	Protein conserved in bacteria
RG48_RS24300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG48_RS24305	COG2104	thiamine diphosphate biosynthetic process
RG48_RS24315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RG48_RS24360	COG0250	Participates in transcription elongation, termination and antitermination
RG48_RS24365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG48_RS24410	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RG48_RS24410	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RG48_RS24460	COG1309	transcriptional regulator
RG48_RS24470	COG0583	DNA-binding transcription factor activity
RG48_RS24475	COG2271	Major facilitator Superfamily
RG48_RS24480	COG4948	Mandelate Racemase Muconate Lactonizing
RG48_RS24495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RG48_RS24510	COG2194	sulfuric ester hydrolase activity
RG48_RS24515	COG2207	Transcriptional regulator
RG48_RS24520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS24525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG48_RS24530	COG1882	Formate acetyltransferase
RG48_RS24535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS24540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS24545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS24545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG48_RS24545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS24550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG48_RS24555	COG0371	Dehydrogenase
RG48_RS24565	COG3738	Protein conserved in bacteria
RG48_RS24570	COG0697	spore germination
RG48_RS24580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RG48_RS24590	COG0527	aspartate kinase activity
RG48_RS24590	COG0460	homoserine dehydrogenase
RG48_RS24595	COG0626	cystathionine gamma-synthase activity
RG48_RS24605	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RG48_RS24635	COG3209	COG3209 Rhs family protein
RG48_RS24645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RG48_RS24650	COG1609	Transcriptional regulator
RG48_RS24655	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG48_RS24670	COG1575	Belongs to the MenA family. Type 1 subfamily
RG48_RS24685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RG48_RS24695	COG1494	fructose-1,6-bisphosphatase
RG48_RS24705	COG0589	response to stress
RG48_RS24710	COG3691	Protein conserved in bacteria
RG48_RS24715	COG3152	Membrane
RG48_RS24740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RG48_RS24755	COG3678	ATP-independent chaperone mediated protein folding
RG48_RS24760	COG0745	RESPONSE REGULATOR receiver
RG48_RS24765	COG2205	protein histidine kinase activity
RG48_RS24770	COG2258	MOSC domain
RG48_RS24790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG48_RS24800	COG4977	sequence-specific DNA binding
RG48_RS24800	COG1917	Cupin 2, conserved barrel domain protein
RG48_RS24835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS24840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS24840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG48_RS24845	COG1363	Peptidase, m42
RG48_RS24850	COG3711	transcriptional antiterminator
RG48_RS24850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG48_RS24870	COG3383	formate dehydrogenase (NAD+) activity
RG48_RS24870	COG0243	molybdopterin cofactor binding
RG48_RS24875	COG3383	formate dehydrogenase (NAD+) activity
RG48_RS24875	COG0243	molybdopterin cofactor binding
RG48_RS24880	COG0437	4 iron, 4 sulfur cluster binding
RG48_RS24885	COG2864	formate dehydrogenase
RG48_RS24900	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG48_RS24905	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG48_RS24910	COG0456	acetyltransferase
RG48_RS24925	COG1011	Hydrolase
RG48_RS24935	COG0477	Major facilitator Superfamily
RG48_RS24945	COG1063	alcohol dehydrogenase
RG48_RS24950	COG3684	Belongs to the aldolase LacD family
RG48_RS24955	COG2084	Dehydrogenase
RG48_RS24960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG48_RS24965	COG1349	DNA-binding transcription factor activity
RG48_RS24970	COG2271	Major facilitator Superfamily
RG48_RS24975	COG1082	Xylose isomerase domain protein TIM barrel
RG48_RS24980	COG2188	Transcriptional regulator
RG48_RS24985	COG1217	gtp-binding protein TYPA
RG48_RS24995	COG0174	glutamine synthetase
RG48_RS25000	COG3852	Histidine kinase
RG48_RS25005	COG2204	response regulator
RG48_RS25015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG48_RS25035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG48_RS25035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG48_RS25045	COG0204	Acyl-transferase
RG48_RS25050	COG5339	Protein conserved in bacteria
RG48_RS25055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG48_RS25060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RG48_RS25065	COG3084	Protein conserved in bacteria
RG48_RS25070	COG0746	molybdenum cofactor guanylyltransferase activity
RG48_RS25075	COG1763	Mo-molybdopterin cofactor biosynthetic process