locus-tag	class	description
RG49_RS00020	COG3038	cytochrome b561
RG49_RS00025	COG3443	Belongs to the bacterial solute-binding protein 9 family
RG49_RS00040	COG2351	hydroxyisourate hydrolase activity
RG49_RS00045	COG0745	RESPONSE REGULATOR receiver
RG49_RS00050	COG2205	protein histidine kinase activity
RG49_RS00095	COG1418	mRNA catabolic process
RG49_RS00100	COG0270	DNA (cytosine-5-)-methyltransferase activity
RG49_RS00105	COG3727	T/G mismatch-specific endonuclease activity
RG49_RS00110	COG0697	spore germination
RG49_RS00115	COG2354	Protein conserved in bacteria
RG49_RS00120	COG5475	Uncharacterized small protein (DUF2158)
RG49_RS00155	COG2197	response regulator
RG49_RS00160	COG1684	flagellar biosynthetic protein fliR
RG49_RS00165	COG1987	bacterial-type flagellum assembly
RG49_RS00170	COG1338	Plays a role in the flagellum-specific transport system
RG49_RS00175	COG3190	flagellar
RG49_RS00180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG49_RS00185	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG49_RS00190	COG1580	Controls the rotational direction of flagella during chemotaxis
RG49_RS00195	COG3144	bacterial-type flagellum assembly
RG49_RS00200	COG2882	bacterial-type flagellum organization
RG49_RS00205	COG1157	protein secretion by the type III secretion system
RG49_RS00210	COG1317	bacterial-type flagellum organization
RG49_RS00215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG49_RS00220	COG1766	The M ring may be actively involved in energy transduction
RG49_RS00235	COG2135	peptidase activity
RG49_RS00240	COG0425	Belongs to the sulfur carrier protein TusA family
RG49_RS00245	COG2391	methyltransferase activity
RG49_RS00260	COG0366	Alpha amylase catalytic
RG49_RS00270	COG1516	flagellar protein fliS
RG49_RS00290	COG1191	sigma factor activity
RG49_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS00310	COG0765	amino acid transport
RG49_RS00315	COG1126	abc transporter atp-binding protein
RG49_RS00320	COG2197	response regulator
RG49_RS00340	COG2197	response regulator
RG49_RS00370	COG3012	SEC-C Motif Domain Protein
RG49_RS00370	COG3318	Belongs to the UPF0149 family
RG49_RS00375	COG0814	amino acid
RG49_RS00385	COG1528	Iron-storage protein
RG49_RS00410	COG1528	Iron-storage protein
RG49_RS00420	COG1879	ABC-type sugar transport system periplasmic component
RG49_RS00425	COG1129	ABC transporter
RG49_RS00430	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG49_RS00435	COG1877	trehalose-phosphatase activity
RG49_RS00445	COG0589	response to stress
RG49_RS00460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RG49_RS00465	COG1360	Flagellar Motor Protein
RG49_RS00470	COG2198	Histidine kinase
RG49_RS00470	COG0643	Histidine kinase
RG49_RS00475	COG0835	chemotaxis
RG49_RS00480	COG0840	transmembrane signaling receptor activity
RG49_RS00485	COG0840	transmembrane signaling receptor activity
RG49_RS00490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RG49_RS00495	COG2201	protein-glutamate methylesterase activity
RG49_RS00500	COG0745	RESPONSE REGULATOR receiver
RG49_RS00505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RG49_RS00510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG49_RS00515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG49_RS00525	COG3755	Protein conserved in bacteria
RG49_RS00540	COG3102	Protein conserved in bacteria
RG49_RS00550	COG3005	denitrification pathway
RG49_RS00555	COG0243	molybdopterin cofactor binding
RG49_RS00570	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RG49_RS00575	COG1801	Protein of unknown function DUF72
RG49_RS00580	COG1335	isochorismatase
RG49_RS00590	COG0494	nUDIX hydrolase
RG49_RS00595	COG0217	transcriptional regulatory protein
RG49_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG49_RS00635	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RG49_RS00640	COG0739	heme binding
RG49_RS00645	COG1560	Kdo2-lipid A biosynthetic process
RG49_RS00650	COG0469	pyruvate kinase activity
RG49_RS00655	COG1737	Transcriptional regulator
RG49_RS00670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RG49_RS00675	COG0129	dihydroxy-acid dehydratase activity
RG49_RS00680	COG0800	Aldolase
RG49_RS00690	COG3141	response to X-ray
RG49_RS00710	COG2979	Protein of unknown function (DUF533)
RG49_RS00720	COG1770	oligopeptidase
RG49_RS00725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG49_RS00730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG49_RS00740	COG2372	response to copper ion
RG49_RS00745	COG1276	copper resistance
RG49_RS00760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG49_RS00780	COG3008	intermembrane lipid transfer
RG49_RS00785	COG2995	paraquat-inducible protein a
RG49_RS00790	COG1956	GAF domain-containing protein
RG49_RS00800	COG0793	Belongs to the peptidase S41A family
RG49_RS00810	COG2814	Major facilitator Superfamily
RG49_RS00815	COG1414	Transcriptional regulator
RG49_RS00850	COG2226	methyltransferase
RG49_RS00870	COG3716	PTS system mannose fructose sorbose family IID component
RG49_RS00875	COG3715	PTS system
RG49_RS00880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS00880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS00895	COG1253	flavin adenine dinucleotide binding
RG49_RS00900	COG2200	EAL domain
RG49_RS00905	COG1760	l-serine dehydratase
RG49_RS00915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG49_RS00930	COG0251	oxidation-reduction process
RG49_RS00935	COG1199	ATP-dependent helicase activity
RG49_RS00940	COG1214	PFAM Peptidase M22, glycoprotease
RG49_RS00945	COG3065	identical protein binding
RG49_RS00950	COG0318	PFAM AMP-dependent synthetase and ligase
RG49_RS00955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RG49_RS00960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG49_RS00970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG49_RS00975	COG0473	3-isopropylmalate dehydrogenase activity
RG49_RS00980	COG0583	DNA-binding transcription factor activity
RG49_RS00990	COG3615	Tellurite resistance protein tehB
RG49_RS01000	COG2261	transglycosylase associated protein
RG49_RS01015	COG2203	Gaf domain
RG49_RS01015	COG2199	diguanylate cyclase activity
RG49_RS01020	COG3042	response to heat
RG49_RS01025	COG3189	MarR family transcriptional regulator
RG49_RS01030	COG2807	transmembrane transport
RG49_RS01035	COG2207	Transcriptional regulator
RG49_RS01050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG49_RS01055	COG2199	diguanylate cyclase activity
RG49_RS01060	COG2199	diguanylate cyclase activity
RG49_RS01070	COG2766	serine protein kinase
RG49_RS01075	COG3713	MltA-interacting MipA family protein
RG49_RS01080	COG0656	L-ascorbic acid biosynthetic process
RG49_RS01085	COG0676	glucose-6-phosphate 1-epimerase activity
RG49_RS01090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG49_RS01100	COG3139	Protein of unknown function (DUF1315)
RG49_RS01110	COG2271	Major facilitator Superfamily
RG49_RS01115	COG1063	alcohol dehydrogenase
RG49_RS01120	COG0191	fructose-bisphosphate aldolase activity
RG49_RS01125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS01130	COG0667	Aldo Keto reductase
RG49_RS01135	COG1349	DNA-binding transcription factor activity
RG49_RS01140	COG2814	Major facilitator Superfamily
RG49_RS01145	COG1335	isochorismatase
RG49_RS01150	COG0252	asparaginase activity
RG49_RS01155	COG0616	signal peptide processing
RG49_RS01160	COG0778	Nitroreductase
RG49_RS01175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG49_RS01185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RG49_RS01195	COG0494	nUDIX hydrolase
RG49_RS01200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG49_RS01205	COG2897	thiosulfate sulfurtransferase activity
RG49_RS01210	COG4136	ATPase activity
RG49_RS01215	COG4135	transport system, permease component
RG49_RS01220	COG4134	Bacterial extracellular solute-binding protein
RG49_RS01225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG49_RS01230	COG0398	Pfam SNARE associated Golgi protein
RG49_RS01240	COG0398	Pfam SNARE associated Golgi protein
RG49_RS01245	COG0708	Exodeoxyribonuclease III
RG49_RS01280	COG3678	ATP-independent chaperone mediated protein folding
RG49_RS01290	COG0322	excinuclease ABC activity
RG49_RS01300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG49_RS01310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG49_RS01315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG49_RS01320	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG49_RS01325	COG1917	Cupin 2, conserved barrel domain protein
RG49_RS01325	COG2169	Transcriptional regulator
RG49_RS01330	COG1486	melibiose metabolic process
RG49_RS01345	COG0753	catalase activity
RG49_RS01360	COG1823	symporter activity
RG49_RS01365	COG1988	membrane-bound metal-dependent
RG49_RS01370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG49_RS01380	COG3001	Fructosamine kinase
RG49_RS01390	COG1105	Belongs to the carbohydrate kinase PfkB family
RG49_RS01395	COG3137	Salt-induced outer membrane protein
RG49_RS01455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG49_RS01455	COG0072	phenylalanine-tRNA ligase activity
RG49_RS01470	COG0386	Belongs to the glutathione peroxidase family
RG49_RS01480	COG0791	NLP P60 protein
RG49_RS01485	COG2200	EAL domain
RG49_RS01495	COG4256	Hemin uptake protein
RG49_RS01500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG49_RS01510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG49_RS01510	COG0574	Belongs to the PEP-utilizing enzyme family
RG49_RS01515	COG0318	PFAM AMP-dependent synthetase and ligase
RG49_RS01520	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG49_RS01525	COG0644	oxidoreductase
RG49_RS01530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG49_RS01535	COG2086	electron transfer activity
RG49_RS01545	COG2207	Transcriptional regulator
RG49_RS01545	COG1917	Cupin 2, conserved barrel domain protein
RG49_RS01550	COG1960	acyl-CoA dehydrogenase activity
RG49_RS01555	COG4670	ketone body catabolic process
RG49_RS01570	COG2271	Major facilitator Superfamily
RG49_RS01575	COG0738	Major facilitator superfamily
RG49_RS01590	COG0628	permease
RG49_RS01600	COG0247	lactate metabolic process
RG49_RS01600	COG0277	FAD linked oxidase domain protein
RG49_RS01605	COG2050	protein possibly involved in aromatic compounds catabolism
RG49_RS01615	COG0316	Belongs to the HesB IscA family
RG49_RS01620	COG0719	Fe-S assembly protein
RG49_RS01625	COG0396	ATPase activity
RG49_RS01630	COG0719	Fe-S assembly protein
RG49_RS01645	COG1376	ErfK ybiS ycfS ynhG family protein
RG49_RS01650	COG4238	major outer membrane lipoprotein
RG49_RS01655	COG0469	pyruvate kinase activity
RG49_RS01665	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS01670	COG2414	aldehyde ferredoxin oxidoreductase
RG49_RS01680	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS01685	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RG49_RS01695	COG4529	Protein conserved in bacteria
RG49_RS01715	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS01725	COG0307	riboflavin synthase, alpha
RG49_RS01730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RG49_RS01735	COG2814	Major facilitator Superfamily
RG49_RS01740	COG0583	DNA-binding transcription factor activity
RG49_RS01760	COG2814	Major facilitator Superfamily
RG49_RS01765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG49_RS01770	COG0791	NLP P60 protein
RG49_RS01775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RG49_RS01780	COG1201	RNA secondary structure unwinding
RG49_RS01785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG49_RS01790	COG0346	lactoylglutathione lyase activity
RG49_RS01795	COG1902	pentaerythritol trinitrate reductase activity
RG49_RS01800	COG1309	transcriptional regulator
RG49_RS01805	COG3313	Fe-S protein
RG49_RS01810	COG4989	oxidoreductase activity
RG49_RS01815	COG2032	superoxide dismutase activity
RG49_RS01820	COG1289	transmembrane transporter activity
RG49_RS01825	COG1566	PFAM secretion protein HlyD family protein
RG49_RS01840	COG3133	Outer membrane lipoprotein
RG49_RS01850	COG3895	Periplasmic Protein
RG49_RS01865	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RG49_RS01870	COG0625	glutathione transferase activity
RG49_RS01875	COG3104	oligopeptide transport
RG49_RS01885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RG49_RS01895	COG4659	FMN binding
RG49_RS01940	COG0673	inositol 2-dehydrogenase activity
RG49_RS01950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RG49_RS01955	COG1263	PTS System
RG49_RS01955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS01960	COG1609	Transcriptional regulator
RG49_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS01970	COG1309	transcriptional regulator
RG49_RS01975	COG3250	beta-galactosidase activity
RG49_RS01990	COG5339	Protein conserved in bacteria
RG49_RS01995	COG1482	cell wall glycoprotein biosynthetic process
RG49_RS02000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG49_RS02000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG49_RS02005	COG0114	fumarate hydratase activity
RG49_RS02015	COG2205	protein histidine kinase activity
RG49_RS02020	COG0745	RESPONSE REGULATOR receiver
RG49_RS02025	COG3136	membrane protein required for alginate biosynthesis
RG49_RS02035	COG0531	amino acid
RG49_RS02050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RG49_RS02055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RG49_RS02060	COG0628	permease
RG49_RS02075	COG3591	Belongs to the peptidase S1B family
RG49_RS02095	COG2814	Major facilitator Superfamily
RG49_RS02100	COG0583	DNA-binding transcription factor activity
RG49_RS02105	COG1940	carbohydrate kinase activity
RG49_RS02110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG49_RS02120	COG3381	protein complex oligomerization
RG49_RS02125	COG3302	dmso reductase anchor subunit
RG49_RS02130	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS02135	COG0243	molybdopterin cofactor binding
RG49_RS02140	COG0243	molybdopterin cofactor binding
RG49_RS02155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG49_RS02175	COG4948	Mandelate Racemase Muconate Lactonizing
RG49_RS02180	COG1063	alcohol dehydrogenase
RG49_RS02190	COG0582	viral genome integration into host DNA
RG49_RS02200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG49_RS02300	COG1403	HNH endonuclease
RG49_RS02305	COG0484	heat shock protein binding
RG49_RS02315	COG1278	Cold shock
RG49_RS02340	COG3772	lysozyme
RG49_RS02350	COG1278	Cold shock
RG49_RS02400	COG0740	serine-type endopeptidase activity
RG49_RS02475	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG49_RS02480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG49_RS02485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG49_RS02495	COG0477	Major facilitator Superfamily
RG49_RS02500	COG0246	Mannitol dehydrogenase
RG49_RS02510	COG1802	Transcriptional regulator
RG49_RS02515	COG4221	oxidoreductase activity
RG49_RS02525	COG0339	signal peptide processing
RG49_RS02530	COG1546	Belongs to the CinA family
RG49_RS02535	COG3111	PFAM Bacterial OB fold (BOF) protein
RG49_RS02540	COG3706	GGDEF domain
RG49_RS02550	COG2814	Major facilitator Superfamily
RG49_RS02555	COG0697	spore germination
RG49_RS02565	COG4977	sequence-specific DNA binding
RG49_RS02570	COG1846	Transcriptional regulator
RG49_RS02590	COG0583	DNA-binding transcription factor activity
RG49_RS02595	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS02600	COG2066	Belongs to the glutaminase family
RG49_RS02610	COG2199	diguanylate cyclase activity
RG49_RS02630	COG3781	membrane
RG49_RS02680	COG1396	sequence-specific DNA binding
RG49_RS02685	COG3550	peptidyl-serine autophosphorylation
RG49_RS02755	COG2801	Transposase and inactivated derivatives
RG49_RS02790	COG4977	sequence-specific DNA binding
RG49_RS02795	COG3188	usher protein
RG49_RS02800	COG3539	Fimbrial protein
RG49_RS02805	COG3539	Fimbrial protein
RG49_RS02810	COG3539	Fimbrial protein
RG49_RS02815	COG0243	molybdopterin cofactor binding
RG49_RS02830	COG3119	arylsulfatase activity
RG49_RS02835	COG0641	radical SAM
RG49_RS02840	COG4178	(ABC) transporter
RG49_RS02845	COG4771	TonB-dependent receptor
RG49_RS02850	COG0612	Peptidase, M16
RG49_RS02865	COG0076	glutamate decarboxylase activity
RG49_RS02870	COG0531	amino acid
RG49_RS02875	COG1649	PFAM Uncharacterised BCR, COG1649
RG49_RS02880	COG3706	GGDEF domain
RG49_RS02885	COG2199	diguanylate cyclase activity
RG49_RS02885	COG2202	Pas domain
RG49_RS02885	COG2200	EAL domain
RG49_RS02890	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RG49_RS02895	COG0747	negative chemotaxis
RG49_RS02900	COG0601	transmembrane transport
RG49_RS02905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG49_RS02910	COG0444	Belongs to the ABC transporter superfamily
RG49_RS02915	COG4608	Belongs to the ABC transporter superfamily
RG49_RS02920	COG1764	response to oxidative stress
RG49_RS02945	COG1064	alcohol dehydrogenase
RG49_RS02950	COG3093	addiction module antidote protein HigA
RG49_RS02960	COG2864	formate dehydrogenase
RG49_RS02965	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS02975	COG0697	spore germination
RG49_RS02980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG49_RS02990	COG1662	PFAM IS1 transposase
RG49_RS03010	COG4886	Leucine-rich repeat (LRR) protein
RG49_RS03015	COG2223	nitrite transmembrane transporter activity
RG49_RS03020	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG49_RS03025	COG1140	nitrate reductase beta subunit
RG49_RS03030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG49_RS03035	COG2181	nitrate reductase activity
RG49_RS03040	COG0384	phenazine biosynthesis protein PhzF
RG49_RS03045	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RG49_RS03050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG49_RS03060	COG5433	transposase activity
RG49_RS03070	COG5433	transposase activity
RG49_RS03075	COG5433	transposase activity
RG49_RS03080	COG2801	Transposase and inactivated derivatives
RG49_RS03095	COG3209	COG3209 Rhs family protein
RG49_RS03110	COG0625	glutathione transferase activity
RG49_RS03115	COG1113	amino acid transport
RG49_RS03120	COG3391	amine dehydrogenase activity
RG49_RS03135	COG4772	TonB-dependent receptor
RG49_RS03140	COG1802	Transcriptional regulator
RG49_RS03145	COG2130	NADP-dependent
RG49_RS03155	COG1247	-acetyltransferase
RG49_RS03160	COG3238	Protein conserved in bacteria
RG49_RS03190	COG1177	transmembrane transport
RG49_RS03195	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG49_RS03200	COG3842	ATPase activity
RG49_RS03205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG49_RS03210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG49_RS03215	COG1598	PFAM Uncharacterised protein family UPF0150
RG49_RS03220	COG1724	mRNA binding
RG49_RS03230	COG0826	peptidase U32
RG49_RS03235	COG1396	sequence-specific DNA binding
RG49_RS03240	COG3135	benzoate transporter
RG49_RS03245	COG0675	Transposase, IS605 OrfB family
RG49_RS03260	COG0500	methyltransferase
RG49_RS03265	COG1275	C4-dicarboxylate transporter malic acid transport protein
RG49_RS03270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG49_RS03275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG49_RS03280	COG2841	Protein conserved in bacteria
RG49_RS03300	COG5383	Protein conserved in bacteria
RG49_RS03305	COG0583	DNA-binding transcription factor activity
RG49_RS03310	COG0840	transmembrane signaling receptor activity
RG49_RS03325	COG3038	cytochrome b561
RG49_RS03330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG49_RS03335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG49_RS03340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG49_RS03345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG49_RS03350	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS03355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG49_RS03360	COG1643	Atp-dependent helicase
RG49_RS03370	COG2453	phosphatase
RG49_RS03370	COG0671	phosphoesterase, PA-phosphatase related
RG49_RS03375	COG2267	carboxylic ester hydrolase activity
RG49_RS03390	COG0667	Aldo Keto reductase
RG49_RS03395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG49_RS03400	COG3327	negative regulation of DNA-templated transcription, initiation
RG49_RS03405	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RG49_RS03410	COG0183	Belongs to the thiolase family
RG49_RS03415	COG2050	protein possibly involved in aromatic compounds catabolism
RG49_RS03420	COG1250	3-hydroxyacyl-CoA dehydrogenase
RG49_RS03425	COG1024	Enoyl-CoA hydratase
RG49_RS03430	COG1024	Enoyl-CoA hydratase
RG49_RS03435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG49_RS03440	COG2151	metal-sulfur cluster biosynthetic enzyme
RG49_RS03445	COG3396	Phenylacetate-CoA oxygenase
RG49_RS03450	COG3460	Phenylacetate-CoA oxygenase
RG49_RS03455	COG3396	Phenylacetate-CoA oxygenase
RG49_RS03460	COG2030	dehydratase
RG49_RS03460	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS03465	COG3733	amine oxidase
RG49_RS03470	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS03475	COG2207	Transcriptional regulator
RG49_RS03480	COG3784	Protein of unknown function (DUF1318)
RG49_RS03490	COG2911	Protein conserved in bacteria
RG49_RS03495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RG49_RS03500	COG3187	Heat shock protein
RG49_RS03505	COG3042	response to heat
RG49_RS03510	COG0674	pyruvate-flavodoxin oxidoreductase activity
RG49_RS03510	COG1013	pyruvate-flavodoxin oxidoreductase activity
RG49_RS03510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RG49_RS03510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG49_RS03535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG49_RS03540	COG0589	response to stress
RG49_RS03600	COG1475	DNA binding
RG49_RS03610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG49_RS03620	COG3772	lysozyme
RG49_RS03635	COG3064	Membrane
RG49_RS03660	COG2814	Major facilitator Superfamily
RG49_RS03665	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RG49_RS03685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG49_RS03770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG49_RS03775	COG3723	Recombinational DNA repair protein, rece pathway
RG49_RS03795	COG0582	viral genome integration into host DNA
RG49_RS03805	COG0513	Belongs to the DEAD box helicase family
RG49_RS03820	COG3706	GGDEF domain
RG49_RS03825	COG2840	Smr protein MutS2
RG49_RS03835	COG0583	DNA-binding transcription factor activity
RG49_RS03840	COG1473	amidohydrolase
RG49_RS03845	COG1473	amidohydrolase
RG49_RS03855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RG49_RS03860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG49_RS03865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG49_RS03870	COG0589	response to stress
RG49_RS03875	COG3182	Iron-regulated membrane protein
RG49_RS03880	COG0668	transmembrane transport
RG49_RS03885	COG4166	transmembrane transport
RG49_RS03895	COG0583	DNA-binding transcription factor activity
RG49_RS03900	COG1073	alpha beta
RG49_RS03905	COG0702	epimerase
RG49_RS03910	COG2866	Carboxypeptidase
RG49_RS03915	COG4948	Mandelate Racemase Muconate Lactonizing
RG49_RS03920	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RG49_RS03925	COG3283	Transcriptional regulator of aromatic amino acids metabolism
RG49_RS03935	COG3106	COG3106 Predicted ATPase
RG49_RS03940	COG1609	Transcriptional regulator
RG49_RS03950	COG3842	ATPase activity
RG49_RS03955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG49_RS03960	COG1554	hydrolase, family 65, central catalytic
RG49_RS03965	COG0673	inositol 2-dehydrogenase activity
RG49_RS03970	COG1082	Xylose isomerase domain protein TIM barrel
RG49_RS03975	COG1063	alcohol dehydrogenase
RG49_RS03980	COG0395	ABC-type sugar transport system, permease component
RG49_RS03985	COG1175	transmembrane transport
RG49_RS03990	COG1653	transport
RG49_RS03995	COG0366	Alpha amylase catalytic
RG49_RS04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG49_RS04010	COG1983	PspC domain protein
RG49_RS04020	COG1842	Phage shock protein A
RG49_RS04025	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RG49_RS04030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG49_RS04035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RG49_RS04040	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS04050	COG1396	sequence-specific DNA binding
RG49_RS04050	COG1917	Cupin 2, conserved barrel domain protein
RG49_RS04055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RG49_RS04060	COG0174	glutamine synthetase
RG49_RS04065	COG0531	amino acid
RG49_RS04080	COG4166	transmembrane transport
RG49_RS04085	COG4168	peptide transport system, permease
RG49_RS04090	COG4171	peptide transport system, permease
RG49_RS04095	COG4172	Belongs to the ABC transporter superfamily
RG49_RS04100	COG4172	Belongs to the ABC transporter superfamily
RG49_RS04105	COG2852	Protein conserved in bacteria
RG49_RS04110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RG49_RS04115	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG49_RS04115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG49_RS04130	COG5001	Diguanylate cyclase
RG49_RS04140	COG1349	DNA-binding transcription factor activity
RG49_RS04150	COG0023	Translation Initiation Factor
RG49_RS04160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RG49_RS04165	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RG49_RS04170	COG0671	phosphoesterase, PA-phosphatase related
RG49_RS04180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG49_RS04200	COG0583	DNA-binding transcription factor activity
RG49_RS04210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG49_RS04220	COG0616	signal peptide processing
RG49_RS04230	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS04235	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RG49_RS04240	COG1187	pseudouridine synthase activity
RG49_RS04245	COG4907	membrane protein (DUF2207)
RG49_RS04250	COG0009	L-threonylcarbamoyladenylate synthase
RG49_RS04255	COG0613	PHP domain protein
RG49_RS04265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG49_RS04270	COG0512	Glutamine amidotransferase of anthranilate synthase
RG49_RS04270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG49_RS04275	COG0134	indole-3-glycerol-phosphate synthase activity
RG49_RS04275	COG0135	phosphoribosylanthranilate isomerase activity
RG49_RS04290	COG3729	General stress protein
RG49_RS04295	COG3685	Protein conserved in bacteria
RG49_RS04300	COG3685	Protein conserved in bacteria
RG49_RS04305	COG3047	cAMP biosynthetic process
RG49_RS04325	COG1607	acyl-coa hydrolase
RG49_RS04330	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RG49_RS04335	COG2350	Protein conserved in bacteria
RG49_RS04340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG49_RS04360	COG4608	Belongs to the ABC transporter superfamily
RG49_RS04365	COG0444	Belongs to the ABC transporter superfamily
RG49_RS04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG49_RS04375	COG0601	transmembrane transport
RG49_RS04380	COG4166	transmembrane transport
RG49_RS04390	COG2095	MarC family integral membrane protein
RG49_RS04395	COG1454	alcohol dehydrogenase
RG49_RS04395	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS04415	COG1435	thymidine kinase activity
RG49_RS04425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG49_RS04430	COG0745	RESPONSE REGULATOR receiver
RG49_RS04435	COG1752	Esterase of the alpha-beta hydrolase superfamily
RG49_RS04445	COG0788	formyltetrahydrofolate deformylase activity
RG49_RS04480	COG2181	nitrate reductase activity
RG49_RS04485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG49_RS04490	COG1140	nitrate reductase beta subunit
RG49_RS04495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG49_RS04500	COG2223	nitrite transmembrane transporter activity
RG49_RS04510	COG3850	Histidine kinase
RG49_RS04515	COG2197	response regulator
RG49_RS04520	COG4932	domain protein
RG49_RS04525	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RG49_RS04530	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RG49_RS04535	COG4572	Cation transport regulator
RG49_RS04540	COG0387	Pfam Sodium calcium exchanger
RG49_RS04560	COG2912	Transglutaminase-like superfamily
RG49_RS04565	COG3094	Invasion gene expression up-regulator, SirB
RG49_RS04570	COG2890	protein-(glutamine-N5) methyltransferase activity
RG49_RS04595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RG49_RS04600	COG0659	secondary active sulfate transmembrane transporter activity
RG49_RS04615	COG0012	GTP binding
RG49_RS04640	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS04645	COG3284	Transcriptional regulator
RG49_RS04650	COG2376	Dihydroxyacetone kinase
RG49_RS04655	COG1461	Dihydroxyacetone kinase
RG49_RS04660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RG49_RS04660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS04660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG49_RS04680	COG2261	transglycosylase associated protein
RG49_RS04685	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RG49_RS04700	COG1619	proteins homologs of microcin C7 resistance protein MccF
RG49_RS04710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG49_RS04720	COG2719	SpoVR family
RG49_RS04735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RG49_RS04740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RG49_RS04745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RG49_RS04760	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG49_RS04795	COG2894	cell division
RG49_RS04855	COG2200	EAL domain
RG49_RS04875	COG1662	PFAM IS1 transposase
RG49_RS04900	COG2200	EAL domain
RG49_RS04905	COG0789	Transcriptional regulator
RG49_RS04910	COG5562	phage envelope protein
RG49_RS04925	COG0538	isocitrate dehydrogenase activity
RG49_RS04930	COG1187	pseudouridine synthase activity
RG49_RS04950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RG49_RS04955	COG0745	RESPONSE REGULATOR receiver
RG49_RS04960	COG2205	protein histidine kinase activity
RG49_RS04965	COG2850	peptidyl-arginine hydroxylation
RG49_RS04980	COG3842	ATPase activity
RG49_RS04990	COG1177	transmembrane transport
RG49_RS04995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG49_RS05030	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG49_RS05035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RG49_RS05045	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG49_RS05050	COG1136	(ABC) transporter
RG49_RS05055	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG49_RS05060	COG4763	Acyl-transferase
RG49_RS05065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RG49_RS05070	COG1376	ErfK ybiS ycfS ynhG family protein
RG49_RS05070	COG1388	LysM domain
RG49_RS05080	COG1309	transcriptional regulator
RG49_RS05085	COG3134	Outer membrane lipoprotein
RG49_RS05095	COG1252	NADH dehydrogenase
RG49_RS05120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
RG49_RS05125	COG5633	Lipoprotein
RG49_RS05130	COG0537	adenosine 5'-monophosphoramidase activity
RG49_RS05135	COG4773	Receptor
RG49_RS05140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS05140	COG1263	PTS System
RG49_RS05145	COG0084	hydrolase, TatD family'
RG49_RS05150	COG0470	DNA polymerase III
RG49_RS05160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RG49_RS05165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG49_RS05170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG49_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS05185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RG49_RS05205	COG1399	metal-binding, possibly nucleic acid-binding protein
RG49_RS05210	COG0424	maF-like protein
RG49_RS05215	COG0564	pseudouridine synthase activity
RG49_RS05225	COG1530	ribonuclease E activity
RG49_RS05230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG49_RS05235	COG1256	bacterial-type flagellum assembly
RG49_RS05240	COG1705	Flagellar rod assembly protein muramidase FlgJ
RG49_RS05240	COG3951	Flagellar rod assembly protein muramidase FlgJ
RG49_RS05255	COG4786	Flagellar basal body rod
RG49_RS05260	COG4787	bacterial-type flagellum-dependent cell motility
RG49_RS05265	COG1749	Flagellar hook protein flgE
RG49_RS05270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RG49_RS05275	COG1558	bacterial-type flagellum-dependent cell motility
RG49_RS05280	COG1815	bacterial-type flagellum-dependent cell motility
RG49_RS05285	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RG49_RS05290	COG2747	anti-sigma28 factor FlgM
RG49_RS05295	COG3418	PFAM FlgN family protein
RG49_RS05300	COG0728	peptidoglycan biosynthetic process
RG49_RS05305	COG0673	inositol 2-dehydrogenase activity
RG49_RS05315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG49_RS05325	COG2999	glutathione oxidoreductase activity
RG49_RS05365	COG3038	cytochrome b561
RG49_RS05370	COG2353	YceI-like domain
RG49_RS05380	COG1560	Kdo2-lipid A biosynthetic process
RG49_RS05400	COG5645	(Lipo)protein
RG49_RS05405	COG2943	transferase activity, transferring hexosyl groups
RG49_RS05420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG49_RS05425	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG49_RS05460	COG2197	response regulator
RG49_RS05475	COG1462	curli production assembly transport component CsgG
RG49_RS05485	COG3381	protein complex oligomerization
RG49_RS05550	COG2801	Transposase and inactivated derivatives
RG49_RS05555	COG3706	GGDEF domain
RG49_RS05560	COG0457	Tetratricopeptide repeat
RG49_RS05565	COG0726	polysaccharide deacetylase
RG49_RS05565	COG1649	PFAM Uncharacterised BCR, COG1649
RG49_RS05570	COG1215	transferase activity, transferring glycosyl groups
RG49_RS05575	COG3658	cytochrome
RG49_RS05580	COG1702	phosphate starvation-inducible protein PhoH
RG49_RS05590	COG2837	iron assimilation
RG49_RS05595	COG2822	iron ion transport
RG49_RS05610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG49_RS05625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG49_RS05625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG49_RS05625	COG0506	proline dehydrogenase activity
RG49_RS05630	COG1309	transcriptional regulator
RG49_RS05665	COG2233	PERMEase
RG49_RS05675	COG3729	General stress protein
RG49_RS05715	COG0243	molybdopterin cofactor binding
RG49_RS05720	COG3005	denitrification pathway
RG49_RS05725	COG0745	RESPONSE REGULATOR receiver
RG49_RS05730	COG1879	ABC-type sugar transport system periplasmic component
RG49_RS05735	COG0784	Response regulator, receiver
RG49_RS05735	COG2198	Histidine kinase
RG49_RS05735	COG2205	protein histidine kinase activity
RG49_RS05740	COG0348	domain, Protein
RG49_RS05760	COG1278	Cold shock
RG49_RS05765	COG1278	Cold shock
RG49_RS05785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG49_RS05790	COG1596	polysaccharide export
RG49_RS05795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG49_RS05800	COG0489	protein tyrosine kinase activity
RG49_RS05800	COG3206	protein involved in exopolysaccharide biosynthesis
RG49_RS05815	COG1294	oxidase, subunit
RG49_RS05820	COG1271	oxidase subunit
RG49_RS05825	COG1773	rubredoxin
RG49_RS05830	COG1999	signal sequence binding
RG49_RS05835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG49_RS05840	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RG49_RS05845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG49_RS05850	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG49_RS05860	COG0670	Belongs to the BI1 family
RG49_RS05865	COG2920	part of a sulfur-relay system
RG49_RS05870	COG1254	Belongs to the acylphosphatase family
RG49_RS05885	COG1832	CoA-binding protein
RG49_RS05905	COG0210	DNA helicase
RG49_RS05910	COG3304	Inner membrane component domain
RG49_RS05915	COG1289	transmembrane transporter activity
RG49_RS05920	COG3070	regulator of competence-specific genes
RG49_RS05935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG49_RS05935	COG2885	chlorophyll binding
RG49_RS05945	COG1067	ATP-dependent peptidase activity
RG49_RS05955	COG3130	regulation of translation
RG49_RS05960	COG3009	Protein conserved in bacteria
RG49_RS05965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG49_RS05965	COG3008	intermembrane lipid transfer
RG49_RS05970	COG2995	paraquat-inducible protein a
RG49_RS05975	COG0488	(ABC) transporter
RG49_RS05985	COG3217	Mosc domain protein beta barrel domain protein
RG49_RS05985	COG0633	Ferredoxin
RG49_RS06000	COG3121	Chaperone
RG49_RS06005	COG3539	Fimbrial protein
RG49_RS06010	COG3539	Fimbrial protein
RG49_RS06015	COG3539	Fimbrial protein
RG49_RS06020	COG3188	usher protein
RG49_RS06025	COG3121	Chaperone
RG49_RS06030	COG3539	Fimbrial protein
RG49_RS06040	COG0431	NADPH-dependent FMN reductase
RG49_RS06045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RG49_RS06055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG49_RS06060	COG1116	anion transmembrane transporter activity
RG49_RS06065	COG0308	aminopeptidase N
RG49_RS06090	COG1448	Aminotransferase
RG49_RS06095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RG49_RS06100	COG3108	Peptidase M15
RG49_RS06110	COG2989	Protein conserved in bacteria
RG49_RS06120	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RG49_RS06130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RG49_RS06135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG49_RS06140	COG3173	Aminoglycoside phosphotransferase
RG49_RS06155	COG3214	Protein conserved in bacteria
RG49_RS06160	COG1663	tetraacyldisaccharide 4'-kinase activity
RG49_RS06165	COG1132	(ABC) transporter
RG49_RS06180	COG0539	negative regulation of cytoplasmic translation
RG49_RS06190	COG0501	Belongs to the peptidase M48B family
RG49_RS06205	COG2323	membrane
RG49_RS06210	COG1944	ATP diphosphatase activity
RG49_RS06215	COG2116	formate transmembrane transporter activity
RG49_RS06220	COG1882	Formate acetyltransferase
RG49_RS06225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG49_RS06230	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG49_RS06235	COG0583	DNA-binding transcription factor activity
RG49_RS06240	COG0531	amino acid
RG49_RS06250	COG1335	isochorismatase
RG49_RS06255	COG3302	dmso reductase anchor subunit
RG49_RS06260	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS06265	COG0243	molybdopterin cofactor binding
RG49_RS06275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RG49_RS06285	COG1674	ftsk spoiiie
RG49_RS06285	COG1178	ABC-type Fe3 transport system permease component
RG49_RS06290	COG1522	sequence-specific DNA binding
RG49_RS06300	COG0492	ferredoxin-NADP+ reductase activity
RG49_RS06305	COG4988	ABC transporter
RG49_RS06310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RG49_RS06340	COG0542	response to heat
RG49_RS06350	COG1278	Cold shock
RG49_RS06355	COG0577	efflux transmembrane transporter activity
RG49_RS06355	COG1136	(ABC) transporter
RG49_RS06360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS06365	COG2990	Protein conserved in bacteria
RG49_RS06370	COG3593	DNA synthesis involved in DNA repair
RG49_RS06390	COG2431	L-lysine efflux transmembrane transporter activity
RG49_RS06400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG49_RS06405	COG0028	Belongs to the TPP enzyme family
RG49_RS06410	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RG49_RS06415	COG0702	epimerase
RG49_RS06420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG49_RS06425	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG49_RS06440	COG1126	abc transporter atp-binding protein
RG49_RS06445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS06450	COG4215	(ABC) transporter
RG49_RS06455	COG4160	amino acid transport
RG49_RS06460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS06480	COG1177	transmembrane transport
RG49_RS06485	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG49_RS06490	COG3842	ATPase activity
RG49_RS06495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG49_RS06515	COG0778	Nitroreductase
RG49_RS06525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG49_RS06580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG49_RS06595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG49_RS06690	COG4695	Portal protein
RG49_RS06730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG49_RS06770	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RG49_RS06775	COG3226	Transcriptional regulator
RG49_RS06780	COG0738	Major facilitator superfamily
RG49_RS06785	COG0561	phosphatase activity
RG49_RS06795	COG2814	Major facilitator Superfamily
RG49_RS06800	COG0671	phosphoesterase, PA-phosphatase related
RG49_RS06805	COG1349	DNA-binding transcription factor activity
RG49_RS06810	COG1686	Belongs to the peptidase S11 family
RG49_RS06815	COG0625	glutathione transferase activity
RG49_RS06820	COG2133	pyrroloquinoline quinone binding
RG49_RS06835	COG2199	diguanylate cyclase activity
RG49_RS06840	COG2200	EAL domain
RG49_RS06845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG49_RS06855	COG0747	negative chemotaxis
RG49_RS06860	COG4172	Belongs to the ABC transporter superfamily
RG49_RS06865	COG1446	asparaginase
RG49_RS06870	COG0303	'Molybdopterin
RG49_RS06875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG49_RS06880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG49_RS06885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG49_RS06890	COG1882	Formate acetyltransferase
RG49_RS06895	COG0561	phosphatase activity
RG49_RS06905	COG0488	(ABC) transporter
RG49_RS06910	COG1376	ErfK ybiS ycfS ynhG family protein
RG49_RS06915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG49_RS06920	COG1321	iron dependent repressor
RG49_RS06930	COG2194	sulfuric ester hydrolase activity
RG49_RS06935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG49_RS06940	COG5006	permease, DMT superfamily
RG49_RS06965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS06970	COG0765	amino acid transport
RG49_RS06975	COG1126	abc transporter atp-binding protein
RG49_RS06985	COG0668	transmembrane transport
RG49_RS07000	COG4774	siderophore transport
RG49_RS07010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG49_RS07020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG49_RS07025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG49_RS07030	COG1199	ATP-dependent helicase activity
RG49_RS07040	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RG49_RS07045	COG0513	Belongs to the DEAD box helicase family
RG49_RS07050	COG1309	transcriptional regulator
RG49_RS07060	COG1131	(ABC) transporter
RG49_RS07065	COG0842	Transport permease protein
RG49_RS07070	COG0842	Transport permease protein
RG49_RS07080	COG3568	Endonuclease Exonuclease Phosphatase
RG49_RS07085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG49_RS07090	COG0392	lysyltransferase activity
RG49_RS07095	COG0670	Belongs to the BI1 family
RG49_RS07100	COG0670	Belongs to the BI1 family
RG49_RS07105	COG0314	molybdopterin synthase activity
RG49_RS07110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RG49_RS07120	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG49_RS07130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RG49_RS07140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG49_RS07145	COG2226	methyltransferase
RG49_RS07160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RG49_RS07165	COG1881	PFAM PEBP family protein
RG49_RS07175	COG4677	pectinesterase activity
RG49_RS07180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG49_RS07185	COG0471	metal ion transport
RG49_RS07190	COG2828	Protein conserved in bacteria
RG49_RS07195	COG0583	DNA-binding transcription factor activity
RG49_RS07205	COG0561	phosphatase activity
RG49_RS07210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RG49_RS07215	COG4149	molybdate abc transporter
RG49_RS07220	COG0725	ABC transporter, periplasmic molybdate-binding protein
RG49_RS07235	COG3585	molybdate ion transport
RG49_RS07235	COG2005	Transcriptional regulator
RG49_RS07240	COG1119	ATPase activity
RG49_RS07245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RG49_RS07250	COG1085	galactose-1-phosphate uridylyltransferase
RG49_RS07260	COG2017	converts alpha-aldose to the beta-anomer
RG49_RS07270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG49_RS07285	COG1230	cation diffusion facilitator family transporter
RG49_RS07290	COG3201	nicotinamide mononucleotide transporter
RG49_RS07335	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RG49_RS07340	COG2885	chlorophyll binding
RG49_RS07350	COG3064	Membrane
RG49_RS07355	COG0848	biopolymer transport protein
RG49_RS07360	COG0811	peptide transport
RG49_RS07365	COG0824	Thioesterase
RG49_RS07370	COG3790	cyd operon protein YbgE
RG49_RS07375	COG4890	Cyd operon protein YbgT
RG49_RS07380	COG1294	oxidase, subunit
RG49_RS07385	COG1271	oxidase subunit
RG49_RS07395	COG0383	alpha-mannosidase activity
RG49_RS07400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS07400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS07400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS07405	COG2188	Transcriptional regulator
RG49_RS07410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG49_RS07420	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG49_RS07425	COG0567	Dehydrogenase, E1 component
RG49_RS07435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG49_RS07440	COG1053	succinate dehydrogenase
RG49_RS07445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RG49_RS07450	COG2009	succinate dehydrogenase
RG49_RS07470	COG0372	Belongs to the citrate synthase family
RG49_RS07475	COG3539	Fimbrial protein
RG49_RS07495	COG3539	Fimbrial protein
RG49_RS07500	COG3188	usher protein
RG49_RS07505	COG3121	Chaperone
RG49_RS07510	COG3539	Fimbrial protein
RG49_RS07515	COG3180	Ammonia monooxygenase
RG49_RS07530	COG1984	allophanate hydrolase subunit 2
RG49_RS07535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RG49_RS07540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RG49_RS07545	COG3104	oligopeptide transport
RG49_RS07550	COG0415	Belongs to the DNA photolyase family
RG49_RS07555	COG3272	Protein of unknown function (DUF1722)
RG49_RS07560	COG5433	transposase activity
RG49_RS07570	COG5433	transposase activity
RG49_RS07580	COG3209	COG3209 Rhs family protein
RG49_RS07590	COG3209	COG3209 Rhs family protein
RG49_RS07620	COG2205	protein histidine kinase activity
RG49_RS07625	COG0745	RESPONSE REGULATOR receiver
RG49_RS07635	COG1982	Orn Lys Arg decarboxylase major
RG49_RS07640	COG0531	amino acid
RG49_RS07660	COG0033	Phosphoglucomutase
RG49_RS07665	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RG49_RS07670	COG0596	Alpha beta hydrolase
RG49_RS07680	COG0716	FMN binding
RG49_RS07695	COG0735	belongs to the Fur family
RG49_RS07720	COG1263	PTS System
RG49_RS07720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS07720	COG2190	(PTS) system
RG49_RS07730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG49_RS07735	COG1846	Transcriptional regulator
RG49_RS07735	COG1940	carbohydrate kinase activity
RG49_RS07740	COG0647	UMP catabolic process
RG49_RS07745	COG0367	asparagine synthase
RG49_RS07795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG49_RS07805	COG1702	phosphate starvation-inducible protein PhoH
RG49_RS07815	COG4535	Mg2 and Co2 transporter CorC
RG49_RS07820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RG49_RS07825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS07830	COG0765	amino acid transport
RG49_RS07835	COG0765	amino acid transport
RG49_RS07840	COG1126	abc transporter atp-binding protein
RG49_RS07870	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG49_RS07875	COG2214	Heat shock protein DnaJ domain protein
RG49_RS07885	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG49_RS07890	COG2888	peptidyl-tyrosine sulfation
RG49_RS07905	COG1466	dna polymerase III delta subunit
RG49_RS07915	COG0406	alpha-ribazole phosphatase activity
RG49_RS07920	COG0799	negative regulation of ribosome biogenesis
RG49_RS07930	COG0768	penicillin binding
RG49_RS07935	COG0772	Belongs to the SEDS family
RG49_RS07940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG49_RS07945	COG1686	Belongs to the peptidase S11 family
RG49_RS07965	COG0583	DNA-binding transcription factor activity
RG49_RS07980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG49_RS07985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG49_RS08010	COG3069	C4-dicarboxylate transmembrane transporter activity
RG49_RS08015	COG4565	transcriptional regulatory protein
RG49_RS08020	COG3290	protein histidine kinase activity
RG49_RS08025	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RG49_RS08035	COG2301	Belongs to the HpcH HpaI aldolase family
RG49_RS08040	COG3051	citrate lyase alpha subunit
RG49_RS08055	COG0471	metal ion transport
RG49_RS08060	COG3719	Belongs to the RNase T2 family
RG49_RS08070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG49_RS08080	COG1063	alcohol dehydrogenase
RG49_RS08085	COG0589	response to stress
RG49_RS08090	COG3634	alkyl hydroperoxide reductase activity
RG49_RS08095	COG0450	alkyl hydroperoxide reductase
RG49_RS08100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG49_RS08110	COG0583	DNA-binding transcription factor activity
RG49_RS08115	COG3969	phosphoadenosine phosphosulfate
RG49_RS08120	COG1475	DNA binding
RG49_RS08125	COG0436	Aminotransferase
RG49_RS08130	COG0371	Dehydrogenase
RG49_RS08135	COG2879	small protein
RG49_RS08140	COG1966	Carbon starvation protein
RG49_RS08145	COG2050	protein possibly involved in aromatic compounds catabolism
RG49_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS08155	COG1535	isochorismatase
RG49_RS08155	COG3433	isochorismatase activity
RG49_RS08160	COG1021	2,3-dihydroxybenzoate-AMP ligase
RG49_RS08165	COG1169	isochorismate synthase
RG49_RS08175	COG4592	Periplasmic binding protein
RG49_RS08185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG49_RS08190	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG49_RS08195	COG1120	ATPase activity
RG49_RS08200	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG49_RS08205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG49_RS08205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RG49_RS08210	COG3251	PFAM MbtH domain protein
RG49_RS08215	COG2382	esterase
RG49_RS08220	COG4771	TonB-dependent receptor
RG49_RS08230	COG2977	Belongs to the P-Pant transferase superfamily
RG49_RS08240	COG3385	transposase activity
RG49_RS08250	COG2801	Transposase and inactivated derivatives
RG49_RS08255	COG2963	transposase activity
RG49_RS08275	COG2315	Protein conserved in bacteria
RG49_RS08280	COG0778	Nitroreductase
RG49_RS08285	COG0668	transmembrane transport
RG49_RS08290	COG1113	amino acid transport
RG49_RS08295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG49_RS08300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS08305	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS08310	COG1538	Outer membrane efflux protein
RG49_RS08320	COG0745	RESPONSE REGULATOR receiver
RG49_RS08325	COG5002	protein histidine kinase activity
RG49_RS08335	COG3501	Rhs element vgr protein
RG49_RS08345	COG3209	COG3209 Rhs family protein
RG49_RS08345	COG4104	PAAR repeat-containing protein
RG49_RS08370	COG5433	transposase activity
RG49_RS08375	COG1215	transferase activity, transferring glycosyl groups
RG49_RS08380	COG4783	chaperone-mediated protein folding
RG49_RS08395	COG2207	Transcriptional regulator
RG49_RS08435	COG2501	S4 domain
RG49_RS08440	COG1988	membrane-bound metal-dependent
RG49_RS08450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG49_RS08465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RG49_RS08470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RG49_RS08475	COG0549	Belongs to the carbamate kinase family
RG49_RS08490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG49_RS08495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG49_RS08500	COG3257	ureidoglycine aminohydrolase activity
RG49_RS08505	COG1929	Belongs to the glycerate kinase type-1 family
RG49_RS08510	COG2233	PERMEase
RG49_RS08520	COG1953	Uracil, thiamine, allantoin
RG49_RS08525	COG2084	Dehydrogenase
RG49_RS08530	COG3622	Belongs to the hyi family
RG49_RS08535	COG3960	tartronate-semialdehyde synthase activity
RG49_RS08540	COG1414	Transcriptional regulator
RG49_RS08550	COG0583	DNA-binding transcription factor activity
RG49_RS08560	COG2801	Transposase and inactivated derivatives
RG49_RS08575	COG3209	COG3209 Rhs family protein
RG49_RS08585	COG3209	COG3209 Rhs family protein
RG49_RS08590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RG49_RS08595	COG4181	ATPase activity
RG49_RS08600	COG2755	lipolytic protein G-D-S-L family
RG49_RS08605	COG0300	oxidoreductase activity
RG49_RS08610	COG3118	belongs to the thioredoxin family
RG49_RS08615	COG0390	transport system, permease component
RG49_RS08620	COG4619	ABC transporter
RG49_RS08625	COG0330	HflC and HflK could
RG49_RS08630	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG49_RS08635	COG0789	Transcriptional regulator
RG49_RS08645	COG0531	amino acid
RG49_RS08650	COG2066	Belongs to the glutaminase family
RG49_RS08655	COG2217	Heavy metal translocating P-type atpase
RG49_RS08675	COG3093	addiction module antidote protein HigA
RG49_RS08680	COG3735	TraB family
RG49_RS08685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG49_RS08690	COG0737	Belongs to the 5'-nucleotidase family
RG49_RS08700	COG2223	nitrite transmembrane transporter activity
RG49_RS08705	COG4651	solute:proton antiporter activity
RG49_RS08705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG49_RS08710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS08745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RG49_RS08760	COG2832	Protein of unknown function (DUF454)
RG49_RS08765	COG3923	Primosomal replication protein n
RG49_RS08775	COG3264	Mechanosensitive ion channel
RG49_RS08775	COG1196	nuclear chromosome segregation
RG49_RS08785	COG1309	transcriptional regulator
RG49_RS08790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS08795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG49_RS08810	COG0110	maltose O-acetyltransferase activity
RG49_RS08820	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG49_RS08825	COG5507	3-demethylubiquinone-9 3-methyltransferase
RG49_RS08840	COG5507	3-demethylubiquinone-9 3-methyltransferase
RG49_RS08850	COG3695	enzyme binding
RG49_RS08855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RG49_RS08860	COG1946	Acyl-CoA thioesterase
RG49_RS08865	COG0004	ammonium transporteR
RG49_RS08870	COG0347	Belongs to the P(II) protein family
RG49_RS08875	COG1132	(ABC) transporter
RG49_RS08880	COG1132	(ABC) transporter
RG49_RS08885	COG1522	sequence-specific DNA binding
RG49_RS08895	COG4533	DNA binding
RG49_RS08905	COG0824	Thioesterase
RG49_RS08910	COG1555	photosystem II stabilization
RG49_RS08915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG49_RS08920	COG0776	regulation of translation
RG49_RS08925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RG49_RS08950	COG0271	Belongs to the BolA IbaG family
RG49_RS08960	COG3056	Lipoprotein
RG49_RS08965	COG2223	nitrite transmembrane transporter activity
RG49_RS08970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RG49_RS08975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RG49_RS08980	COG1845	cytochrome c oxidase, subunit III
RG49_RS08985	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RG49_RS08995	COG2814	Major facilitator Superfamily
RG49_RS09005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RG49_RS09010	COG0693	protein deglycase activity
RG49_RS09025	COG0142	geranyltranstransferase activity
RG49_RS09035	COG0667	Aldo Keto reductase
RG49_RS09040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RG49_RS09045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RG49_RS09060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG49_RS09060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG49_RS09070	COG4238	major outer membrane lipoprotein
RG49_RS09075	COG3248	Nucleoside-binding outer membrane protein
RG49_RS09080	COG1403	HNH endonuclease
RG49_RS09085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG49_RS09090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG49_RS09095	COG1862	Preprotein translocase
RG49_RS09115	COG0366	Alpha amylase catalytic
RG49_RS09120	COG1113	amino acid transport
RG49_RS09125	COG1114	Component of the transport system for branched-chain amino acids
RG49_RS09130	COG5002	protein histidine kinase activity
RG49_RS09135	COG0745	RESPONSE REGULATOR receiver
RG49_RS09140	COG0420	3'-5' exonuclease activity
RG49_RS09145	COG0419	ATPase involved in DNA repair
RG49_RS09150	COG2814	Major facilitator Superfamily
RG49_RS09155	COG1940	carbohydrate kinase activity
RG49_RS09180	COG4126	flavin adenine dinucleotide binding
RG49_RS09205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RG49_RS09210	COG3706	GGDEF domain
RG49_RS09220	COG1785	Belongs to the alkaline phosphatase family
RG49_RS09235	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG49_RS09255	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RG49_RS09265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG49_RS09270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG49_RS09275	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS09285	COG0113	porphobilinogen synthase activity
RG49_RS09290	COG2175	clavaminate synthase activity
RG49_RS09295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG49_RS09300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RG49_RS09305	COG4521	taurine ABC transporter
RG49_RS09315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RG49_RS09320	COG1215	transferase activity, transferring glycosyl groups
RG49_RS09350	COG3122	Protein conserved in bacteria
RG49_RS09355	COG2814	Major facilitator Superfamily
RG49_RS09380	COG3971	2-oxopent-4-enoate hydratase activity
RG49_RS09400	COG1414	Transcriptional regulator
RG49_RS09405	COG1609	Transcriptional regulator
RG49_RS09415	COG3250	beta-galactosidase activity
RG49_RS09420	COG2223	nitrite transmembrane transporter activity
RG49_RS09425	COG0110	maltose O-acetyltransferase activity
RG49_RS09430	COG2807	transmembrane transport
RG49_RS09440	COG0288	reversible hydration of carbon dioxide
RG49_RS09445	COG0583	DNA-binding transcription factor activity
RG49_RS09450	COG0402	S-adenosylhomocysteine deaminase activity
RG49_RS09455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RG49_RS09465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG49_RS09470	COG2079	MmgE PrpD family protein
RG49_RS09475	COG0372	Belongs to the citrate synthase family
RG49_RS09485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RG49_RS09490	COG3829	transcription factor binding
RG49_RS09500	COG1280	lysine exporter protein (LysE YggA)
RG49_RS09515	COG1064	alcohol dehydrogenase
RG49_RS09520	COG0402	S-adenosylhomocysteine deaminase activity
RG49_RS09525	COG0549	Belongs to the carbamate kinase family
RG49_RS09535	COG1304	FMN binding
RG49_RS09540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG49_RS09550	COG0666	response to abiotic stimulus
RG49_RS09565	COG0583	DNA-binding transcription factor activity
RG49_RS09570	COG2200	EAL domain
RG49_RS09570	COG2771	luxR family
RG49_RS09590	COG2200	EAL domain
RG49_RS09590	COG2771	luxR family
RG49_RS09605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG49_RS09645	COG1556	Lactate utilization protein
RG49_RS09650	COG1139	Iron-sulfur cluster binding protein
RG49_RS09655	COG0247	lactate metabolic process
RG49_RS09660	COG2207	Transcriptional regulator
RG49_RS09665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG49_RS09675	COG3059	membrane
RG49_RS09725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG49_RS09740	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG49_RS09770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG49_RS09785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG49_RS09870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG49_RS09880	COG1061	Type III restriction enzyme res subunit
RG49_RS09900	COG1662	PFAM IS1 transposase
RG49_RS09905	COG1178	ABC-type Fe3 transport system permease component
RG49_RS09910	COG3842	ATPase activity
RG49_RS09915	COG2040	homocysteine
RG49_RS09920	COG0833	amino acid
RG49_RS09925	COG2814	Major facilitator Superfamily
RG49_RS09965	COG3328	transposase activity
RG49_RS09995	COG0071	Belongs to the small heat shock protein (HSP20) family
RG49_RS10000	COG0542	response to heat
RG49_RS10010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG49_RS10070	COG2963	transposase activity
RG49_RS10075	COG2826	transposase and inactivated derivatives, IS30 family
RG49_RS10080	COG2963	transposase activity
RG49_RS10085	COG3596	GTP binding
RG49_RS10095	COG2378	regulation of single-species biofilm formation
RG49_RS10125	COG2003	Belongs to the UPF0758 family
RG49_RS10175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG49_RS10190	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG49_RS10200	COG3778	Protein conserved in bacteria
RG49_RS10205	COG3299	homolog of phage Mu protein gp47
RG49_RS10225	COG4228	DNA circulation
RG49_RS10255	COG4386	tail sheath protein
RG49_RS10300	COG4695	Portal protein
RG49_RS10310	COG4626	Terminase
RG49_RS10310	COG1802	Transcriptional regulator
RG49_RS10355	COG1403	HNH endonuclease
RG49_RS10365	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
RG49_RS10375	COG4725	Belongs to the MT-A70-like family
RG49_RS10385	COG1846	Transcriptional regulator
RG49_RS10430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RG49_RS10450	COG0582	viral genome integration into host DNA
RG49_RS10470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG49_RS10490	COG2195	Cleaves the N-terminal amino acid of tripeptides
RG49_RS10495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG49_RS10500	COG1690	Belongs to the RtcB family
RG49_RS10505	COG0454	-acetyltransferase
RG49_RS10515	COG2161	toxin-antitoxin pair type II binding
RG49_RS10540	COG1943	Transposase
RG49_RS10545	COG0791	NLP P60 protein
RG49_RS10550	COG3077	Addiction module antitoxin, RelB DinJ family
RG49_RS10555	COG3041	Addiction module toxin RelE StbE family
RG49_RS10560	COG3034	peptidoglycan biosynthetic process
RG49_RS10565	COG0121	glutamine amidotransferase
RG49_RS10575	COG1960	acyl-CoA dehydrogenase activity
RG49_RS10585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG49_RS10590	COG5433	transposase activity
RG49_RS10600	COG3209	COG3209 Rhs family protein
RG49_RS10705	COG3157	Type VI secretion system effector, Hcp
RG49_RS10710	COG4104	PAAR repeat-containing protein
RG49_RS10730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG49_RS10740	COG2226	methyltransferase
RG49_RS10750	COG1388	LysM domain
RG49_RS10750	COG0741	lytic transglycosylase activity
RG49_RS10755	COG2226	methyltransferase
RG49_RS10765	COG0583	DNA-binding transcription factor activity
RG49_RS10770	COG0656	L-ascorbic acid biosynthetic process
RG49_RS10810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG49_RS10815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RG49_RS10820	COG2011	ABC-type metal ion transport system permease component
RG49_RS10825	COG1464	Belongs to the NlpA lipoprotein family
RG49_RS10835	COG1720	tRNA m6t6A37 methyltransferase activity
RG49_RS10845	COG0791	NLP P60 protein
RG49_RS10850	COG3015	lipoprotein NlpE involved in copper resistance
RG49_RS10855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG49_RS10860	COG4681	YaeQ
RG49_RS10870	COG4568	rho-dependent transcription termination
RG49_RS10875	COG0037	tRNA processing
RG49_RS10880	COG0346	lactoylglutathione lyase activity
RG49_RS10885	COG1982	Orn Lys Arg decarboxylase major
RG49_RS10895	COG0587	DNA-directed DNA polymerase activity
RG49_RS10920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RG49_RS10925	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RG49_RS10935	COG0750	zinc metalloprotease
RG49_RS10940	COG0575	Belongs to the CDS family
RG49_RS10945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RG49_RS10950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RG49_RS10985	COG0024	Methionine aminopeptidase
RG49_RS11000	COG1408	metallophosphoesterase
RG49_RS11010	COG3835	regulator
RG49_RS11015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG49_RS11035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG49_RS11040	COG2860	membrane
RG49_RS11060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG49_RS11065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG49_RS11070	COG1120	ATPase activity
RG49_RS11075	COG4774	siderophore transport
RG49_RS11080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RG49_RS11090	COG1643	Atp-dependent helicase
RG49_RS11095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RG49_RS11105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG49_RS11115	COG0617	tRNA 3'-terminal CCA addition
RG49_RS11120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RG49_RS11145	COG3188	usher protein
RG49_RS11150	COG3539	Fimbrial protein
RG49_RS11155	COG3539	Fimbrial protein
RG49_RS11160	COG3539	Fimbrial protein
RG49_RS11165	COG3539	Fimbrial protein
RG49_RS11180	COG5464	transposase or invertase
RG49_RS11200	COG0726	polysaccharide deacetylase
RG49_RS11205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS11210	COG0842	Transport permease protein
RG49_RS11215	COG1131	(ABC) transporter
RG49_RS11220	COG0288	reversible hydration of carbon dioxide
RG49_RS11225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RG49_RS11230	COG4993	Dehydrogenase
RG49_RS11235	COG2132	Multicopper oxidase
RG49_RS11260	COG1049	propionate catabolic process, 2-methylcitrate cycle
RG49_RS11270	COG3064	Membrane
RG49_RS11275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG49_RS11280	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG49_RS11285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RG49_RS11295	COG2186	Transcriptional regulator
RG49_RS11300	COG1113	amino acid transport
RG49_RS11305	COG3725	Membrane protein required for beta-lactamase induction
RG49_RS11310	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG49_RS11315	COG0157	Belongs to the NadC ModD family
RG49_RS11325	COG4969	Belongs to the N-Me-Phe pilin family
RG49_RS11330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG49_RS11335	COG1459	type II secretion system
RG49_RS11345	COG0237	dephospho-CoA kinase activity
RG49_RS11360	COG0494	nUDIX hydrolase
RG49_RS11380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RG49_RS11385	COG0849	cell division
RG49_RS11390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RG49_RS11395	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG49_RS11410	COG0772	Belongs to the SEDS family
RG49_RS11415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RG49_RS11425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RG49_RS11430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG49_RS11435	COG0768	penicillin binding
RG49_RS11440	COG3116	cell division
RG49_RS11450	COG2001	Belongs to the MraZ family
RG49_RS11460	COG1609	Transcriptional regulator
RG49_RS11470	COG0440	acetolactate synthase activity
RG49_RS11475	COG0028	Belongs to the TPP enzyme family
RG49_RS11480	COG0583	DNA-binding transcription factor activity
RG49_RS11495	COG0473	3-isopropylmalate dehydrogenase activity
RG49_RS11510	COG2814	Major facilitator Superfamily
RG49_RS11525	COG4143	(ABC) transporter
RG49_RS11530	COG1178	ABC-type Fe3 transport system permease component
RG49_RS11540	COG0586	Pfam SNARE associated Golgi protein
RG49_RS11545	COG4977	sequence-specific DNA binding
RG49_RS11570	COG0235	Class ii aldolase
RG49_RS11575	COG0417	DNA replication proofreading
RG49_RS11585	COG0564	pseudouridine synthase activity
RG49_RS11590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RG49_RS11595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG49_RS11600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG49_RS11625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RG49_RS11640	COG2271	Major facilitator Superfamily
RG49_RS11645	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG49_RS11650	COG0644	oxidoreductase
RG49_RS11705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RG49_RS11710	COG0505	Belongs to the CarA family
RG49_RS11730	COG1047	Peptidyl-prolyl cis-trans
RG49_RS11745	COG0196	riboflavin kinase activity
RG49_RS11765	COG3188	usher protein
RG49_RS11775	COG0583	DNA-binding transcription factor activity
RG49_RS11790	COG2963	transposase activity
RG49_RS11795	COG2801	Transposase and inactivated derivatives
RG49_RS11805	COG3385	transposase activity
RG49_RS11830	COG4735	regulation of single-species biofilm formation
RG49_RS11835	COG1584	GPR1 FUN34 yaaH family protein
RG49_RS11840	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG49_RS11850	COG1115	amino acid carrier protein
RG49_RS11870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RG49_RS11880	COG0460	homoserine dehydrogenase
RG49_RS11880	COG0527	aspartate kinase activity
RG49_RS11890	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RG49_RS11900	COG0745	RESPONSE REGULATOR receiver
RG49_RS11910	COG2205	protein histidine kinase activity
RG49_RS11915	COG0745	RESPONSE REGULATOR receiver
RG49_RS11920	COG3045	CreA protein
RG49_RS11925	COG3708	Transcriptional regulator
RG49_RS11925	COG2207	Transcriptional regulator
RG49_RS11945	COG0741	lytic transglycosylase activity
RG49_RS11955	COG0488	(ABC) transporter
RG49_RS11965	COG1056	cytidyltransferase-related domain
RG49_RS11965	COG3172	ATPase kinase involved in NAD metabolism
RG49_RS11970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RG49_RS11975	COG0560	Phosphoserine phosphatase
RG49_RS11980	COG3726	membrane protein affecting hemolysin expression
RG49_RS12020	COG1328	CTP reductase activity
RG49_RS12025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG49_RS12035	COG0084	hydrolase, TatD family'
RG49_RS12040	COG4667	esterase of the alpha-beta hydrolase superfamily
RG49_RS12050	COG2823	Periplasmic or secreted lipoprotein
RG49_RS12060	COG1011	Hydrolase
RG49_RS12065	COG0456	acetyltransferase
RG49_RS12070	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
RG49_RS12105	COG4114	ferric iron reductase
RG49_RS12110	COG2197	response regulator
RG49_RS12115	COG2197	response regulator
RG49_RS12120	COG2966	Psort location CytoplasmicMembrane, score
RG49_RS12135	COG1484	DNA-dependent DNA replication
RG49_RS12150	COG1063	alcohol dehydrogenase
RG49_RS12155	COG1802	Transcriptional regulator
RG49_RS12160	COG0025	NhaP-type Na H and K H
RG49_RS12165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG49_RS12180	COG0840	transmembrane signaling receptor activity
RG49_RS12185	COG1846	Transcriptional regulator
RG49_RS12190	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG49_RS12195	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS12200	COG3384	dioxygenase
RG49_RS12210	COG3971	2-oxopent-4-enoate hydratase activity
RG49_RS12230	COG2368	4-hydroxyphenylacetate
RG49_RS12235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG49_RS12240	COG1966	Carbon starvation protein
RG49_RS12245	COG2879	small protein
RG49_RS12250	COG0523	cobalamin synthesis protein
RG49_RS12270	COG0732	type I restriction modification DNA specificity domain
RG49_RS12285	COG5457	Domain of unknown function (DUF1127)
RG49_RS12290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG49_RS12305	COG2814	Major facilitator Superfamily
RG49_RS12310	COG2733	membrane
RG49_RS12315	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RG49_RS12320	COG1924	4 iron, 4 sulfur cluster binding
RG49_RS12335	COG0477	Major facilitator Superfamily
RG49_RS12350	COG3366	ferrous iron transmembrane transporter activity
RG49_RS12355	COG0700	Nucleoside recognition
RG49_RS12360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG49_RS12365	COG0583	DNA-binding transcription factor activity
RG49_RS12385	COG2186	Transcriptional regulator
RG49_RS12390	COG0246	Mannitol dehydrogenase
RG49_RS12405	COG3539	Fimbrial protein
RG49_RS12410	COG3539	Fimbrial protein
RG49_RS12415	COG3539	Fimbrial protein
RG49_RS12420	COG3188	usher protein
RG49_RS12425	COG3121	Chaperone
RG49_RS12430	COG3539	Fimbrial protein
RG49_RS12445	COG4974	Belongs to the 'phage' integrase family
RG49_RS12450	COG0582	viral genome integration into host DNA
RG49_RS12465	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG49_RS12470	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
RG49_RS12570	COG1064	alcohol dehydrogenase
RG49_RS12575	COG0433	COG0433 Predicted ATPase
RG49_RS12580	COG0795	lipopolysaccharide-transporting ATPase activity
RG49_RS12585	COG0795	lipopolysaccharide-transporting ATPase activity
RG49_RS12600	COG2927	DNA polymerase III (CHI subunit)
RG49_RS12610	COG4269	membrane
RG49_RS12615	COG0456	acetyltransferase
RG49_RS12620	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
RG49_RS12635	COG2731	YhcH YjgK YiaL family protein
RG49_RS12640	COG1309	transcriptional regulator
RG49_RS12645	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS12650	COG0251	oxidation-reduction process
RG49_RS12675	COG0251	oxidation-reduction process
RG49_RS12680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RG49_RS12685	COG1609	Transcriptional regulator
RG49_RS12690	COG1263	PTS System
RG49_RS12690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS12695	COG0366	Alpha amylase catalytic
RG49_RS12700	COG1328	CTP reductase activity
RG49_RS12710	COG0602	queuosine metabolic process
RG49_RS12715	COG3783	Cytochrome b(562)
RG49_RS12720	COG0312	modulator of DNA gyrase
RG49_RS12730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RG49_RS12740	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG49_RS12745	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG49_RS12750	COG1129	ABC transporter
RG49_RS12755	COG1879	ABC-type sugar transport system periplasmic component
RG49_RS12760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RG49_RS12765	COG2105	PFAM AIG2 family protein
RG49_RS12770	COG2911	Protein conserved in bacteria
RG49_RS12775	COG0729	surface antigen
RG49_RS12790	COG1253	flavin adenine dinucleotide binding
RG49_RS12800	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG49_RS12805	COG1218	3'(2'),5'-bisphosphate nucleotidase
RG49_RS12810	COG0737	Belongs to the 5'-nucleotidase family
RG49_RS12815	COG1733	regulation of RNA biosynthetic process
RG49_RS12820	COG0702	epimerase
RG49_RS12825	COG0697	spore germination
RG49_RS12835	COG1113	amino acid transport
RG49_RS12840	COG0545	Peptidyl-prolyl cis-trans isomerase
RG49_RS12850	COG3061	Opacity-associated protein A
RG49_RS12855	COG1309	transcriptional regulator
RG49_RS12860	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS12870	COG1024	Enoyl-CoA hydratase
RG49_RS12875	COG4670	ketone body catabolic process
RG49_RS12880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG49_RS12885	COG2271	Major facilitator Superfamily
RG49_RS12895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RG49_RS12940	COG3414	Phosphotransferase system galactitol-specific IIB component
RG49_RS12960	COG1073	alpha beta
RG49_RS12965	COG3650	response to hydrogen peroxide
RG49_RS12980	COG1960	acyl-CoA dehydrogenase activity
RG49_RS12985	COG0754	glutathionylspermidine amidase activity
RG49_RS12990	COG5463	Belongs to the UPF0441 family
RG49_RS12995	COG3766	membrane
RG49_RS13005	COG1842	Phage shock protein A
RG49_RS13010	COG3789	protein conserved in bacteria
RG49_RS13015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG49_RS13020	COG0557	exoribonuclease II activity
RG49_RS13035	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RG49_RS13040	COG0330	HflC and HflK could
RG49_RS13045	COG0330	HflC and HflK could
RG49_RS13050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RG49_RS13070	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG49_RS13075	COG0802	atpase or kinase
RG49_RS13080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RG49_RS13080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RG49_RS13085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG49_RS13120	COG1511	domain protein
RG49_RS13120	COG3264	Mechanosensitive ion channel
RG49_RS13135	COG0531	amino acid
RG49_RS13145	COG1053	succinate dehydrogenase
RG49_RS13150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG49_RS13165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG49_RS13170	COG3040	lipid binding
RG49_RS13175	COG2076	Multidrug Resistance protein
RG49_RS13180	COG5510	response to toxic substance
RG49_RS13185	COG5510	response to toxic substance
RG49_RS13195	COG1509	lysine 2,3-aminomutase activity
RG49_RS13220	COG0531	amino acid
RG49_RS13225	COG3030	protein affecting phage T7 exclusion by the F plasmid
RG49_RS13235	COG1027	Aspartate ammonia-lyase
RG49_RS13240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG49_RS13250	COG4232	protein-disulfide reductase activity
RG49_RS13255	COG1309	transcriptional regulator
RG49_RS13270	COG3710	Transcriptional regulator
RG49_RS13275	COG0531	amino acid
RG49_RS13280	COG1982	Orn Lys Arg decarboxylase major
RG49_RS13285	COG3104	oligopeptide transport
RG49_RS13290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG49_RS13310	COG2388	GCN5-related N-acetyl-transferase
RG49_RS13315	COG3592	Divergent 4Fe-4S mono-cluster
RG49_RS13320	COG3290	protein histidine kinase activity
RG49_RS13325	COG4565	transcriptional regulatory protein
RG49_RS13335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG49_RS13340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG49_RS13340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG49_RS13345	COG3647	Membrane
RG49_RS13350	COG2211	Major facilitator Superfamily
RG49_RS13355	COG1486	melibiose metabolic process
RG49_RS13365	COG2169	Transcriptional regulator
RG49_RS13370	COG1982	Orn Lys Arg decarboxylase major
RG49_RS13375	COG2207	Transcriptional regulator
RG49_RS13380	COG0531	amino acid
RG49_RS13385	COG2194	sulfuric ester hydrolase activity
RG49_RS13390	COG0745	RESPONSE REGULATOR receiver
RG49_RS13395	COG0642	Histidine kinase
RG49_RS13405	COG0477	Major facilitator Superfamily
RG49_RS13415	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RG49_RS13425	COG2824	Alkylphosphonate utilization operon protein PhnA
RG49_RS13445	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RG49_RS13450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RG49_RS13455	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RG49_RS13460	COG3639	organic phosphonate transmembrane transporter activity
RG49_RS13465	COG2188	Transcriptional regulator
RG49_RS13470	COG3624	Phosphonate C-P lyase system protein PhnG
RG49_RS13475	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RG49_RS13480	COG3626	phosphonate metabolism
RG49_RS13485	COG3627	carbon phosphorus lyase activity
RG49_RS13490	COG4107	phosphonate C-P lyase system protein PhnK
RG49_RS13500	COG4778	phosphonate C-P lyase system protein PhnL
RG49_RS13505	COG3454	Phosphonate metabolism
RG49_RS13510	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RG49_RS13515	COG0456	acetyltransferase
RG49_RS13520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RG49_RS13530	COG0698	ribose 5-phosphate isomerase
RG49_RS13540	COG1737	Transcriptional regulator
RG49_RS13550	COG1129	ABC transporter
RG49_RS13555	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG49_RS13560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG49_RS13565	COG1940	carbohydrate kinase activity
RG49_RS13570	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RG49_RS13580	COG1566	PFAM secretion protein HlyD family protein
RG49_RS13585	COG1289	transmembrane transporter activity
RG49_RS13590	COG1538	Outer membrane efflux protein
RG49_RS13595	COG3383	formate dehydrogenase (NAD+) activity
RG49_RS13600	COG3383	formate dehydrogenase (NAD+) activity
RG49_RS13605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG49_RS13610	COG1301	dicarboxylic acid transport
RG49_RS13620	COG4235	cytochrome complex assembly
RG49_RS13625	COG3088	subunit of a heme lyase
RG49_RS13630	COG1138	Cytochrome C-type biogenesis protein
RG49_RS13635	COG3301	Polysulphide reductase, NrfD
RG49_RS13640	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS13645	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RG49_RS13660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG49_RS13665	COG3162	membrane
RG49_RS13675	COG1357	PFAM Pentapeptide repeats (8 copies)
RG49_RS13680	COG0025	NhaP-type Na H and K H
RG49_RS13685	COG2252	PERMEase
RG49_RS13705	COG0789	Transcriptional regulator
RG49_RS13710	COG2207	Transcriptional regulator
RG49_RS13715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG49_RS13730	COG0629	single-stranded DNA binding
RG49_RS13735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RG49_RS13740	COG2315	Protein conserved in bacteria
RG49_RS13745	COG0432	Pfam Uncharacterised protein family UPF0047
RG49_RS13750	COG3700	Belongs to the class B bacterial acid phosphatase family
RG49_RS13760	COG1448	Aminotransferase
RG49_RS13765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG49_RS13770	COG0305	Participates in initiation and elongation during chromosome replication
RG49_RS13775	COG0604	alcohol dehydrogenase
RG49_RS13785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG49_RS13800	COG0735	belongs to the Fur family
RG49_RS13805	COG3237	CsbD-like
RG49_RS13810	COG0534	Mate efflux family protein
RG49_RS13820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RG49_RS13850	COG1357	PFAM Pentapeptide repeats (8 copies)
RG49_RS13870	COG3842	ATPase activity
RG49_RS13880	COG2182	Extracellular solute-binding protein
RG49_RS13885	COG1175	transmembrane transport
RG49_RS13890	COG3833	ABC-type maltose transport systems, permease component
RG49_RS13895	COG2814	Major facilitator Superfamily
RG49_RS13895	COG0477	Major facilitator Superfamily
RG49_RS13915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG49_RS13945	COG0527	aspartate kinase activity
RG49_RS13955	COG1187	pseudouridine synthase activity
RG49_RS13965	COG1283	sodium-dependent phosphate transmembrane transporter activity
RG49_RS13970	COG0646	methionine synthase
RG49_RS13970	COG1410	methionine synthase
RG49_RS13975	COG1414	Transcriptional regulator
RG49_RS13995	COG2224	Isocitrate lyase
RG49_RS14000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG49_RS14010	COG0456	acetyltransferase
RG49_RS14055	COG0151	Belongs to the GarS family
RG49_RS14060	COG2204	response regulator
RG49_RS14065	COG4191	Histidine kinase
RG49_RS14075	COG3678	ATP-independent chaperone mediated protein folding
RG49_RS14090	COG3068	Protein conserved in bacteria
RG49_RS14125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG49_RS14130	COG2104	thiamine diphosphate biosynthetic process
RG49_RS14140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RG49_RS14185	COG0250	Participates in transcription elongation, termination and antitermination
RG49_RS14190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG49_RS14235	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RG49_RS14235	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RG49_RS14240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RG49_RS14275	COG4206	TonB-dependent receptor
RG49_RS14290	COG1309	transcriptional regulator
RG49_RS14305	COG0583	DNA-binding transcription factor activity
RG49_RS14320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RG49_RS14340	COG2194	sulfuric ester hydrolase activity
RG49_RS14350	COG2207	Transcriptional regulator
RG49_RS14355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS14360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG49_RS14365	COG1882	Formate acetyltransferase
RG49_RS14370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS14375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS14380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS14380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS14380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG49_RS14385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG49_RS14390	COG0371	Dehydrogenase
RG49_RS14400	COG3738	Protein conserved in bacteria
RG49_RS14405	COG0697	spore germination
RG49_RS14415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RG49_RS14425	COG0460	homoserine dehydrogenase
RG49_RS14425	COG0527	aspartate kinase activity
RG49_RS14430	COG0626	cystathionine gamma-synthase activity
RG49_RS14440	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RG49_RS14450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RG49_RS14455	COG1609	Transcriptional regulator
RG49_RS14460	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG49_RS14475	COG1575	Belongs to the MenA family. Type 1 subfamily
RG49_RS14490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RG49_RS14500	COG1494	fructose-1,6-bisphosphatase
RG49_RS14505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG49_RS14510	COG0589	response to stress
RG49_RS14515	COG3691	Protein conserved in bacteria
RG49_RS14520	COG3152	Membrane
RG49_RS14545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RG49_RS14570	COG3678	ATP-independent chaperone mediated protein folding
RG49_RS14575	COG0745	RESPONSE REGULATOR receiver
RG49_RS14580	COG2205	protein histidine kinase activity
RG49_RS14585	COG2258	MOSC domain
RG49_RS14605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG49_RS14655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS14660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS14660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS14665	COG1363	Peptidase, m42
RG49_RS14670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS14670	COG3711	transcriptional antiterminator
RG49_RS14690	COG0243	molybdopterin cofactor binding
RG49_RS14690	COG3383	formate dehydrogenase (NAD+) activity
RG49_RS14695	COG3383	formate dehydrogenase (NAD+) activity
RG49_RS14695	COG0243	molybdopterin cofactor binding
RG49_RS14700	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS14705	COG2864	formate dehydrogenase
RG49_RS14720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG49_RS14725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG49_RS14730	COG0456	acetyltransferase
RG49_RS14745	COG1011	Hydrolase
RG49_RS14750	COG1349	DNA-binding transcription factor activity
RG49_RS14755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS14760	COG2084	Dehydrogenase
RG49_RS14765	COG3684	Belongs to the aldolase LacD family
RG49_RS14770	COG2942	2-epimerase
RG49_RS14775	COG2017	converts alpha-aldose to the beta-anomer
RG49_RS14785	COG1501	Belongs to the glycosyl hydrolase 31 family
RG49_RS14790	COG2211	Major facilitator Superfamily
RG49_RS14795	COG2211	Major facilitator Superfamily
RG49_RS14800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG49_RS14805	COG2271	Major facilitator Superfamily
RG49_RS14810	COG1082	Xylose isomerase domain protein TIM barrel
RG49_RS14815	COG2188	Transcriptional regulator
RG49_RS14820	COG1217	gtp-binding protein TYPA
RG49_RS14830	COG0174	glutamine synthetase
RG49_RS14835	COG3852	Histidine kinase
RG49_RS14840	COG2204	response regulator
RG49_RS14850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG49_RS14855	COG3078	GTPase activator activity
RG49_RS14870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG49_RS14870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG49_RS14880	COG0204	Acyl-transferase
RG49_RS14885	COG5339	Protein conserved in bacteria
RG49_RS14890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG49_RS14895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RG49_RS14900	COG3084	Protein conserved in bacteria
RG49_RS14905	COG0746	molybdenum cofactor guanylyltransferase activity
RG49_RS14910	COG1763	Mo-molybdopterin cofactor biosynthetic process
RG49_RS14940	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
RG49_RS14945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG49_RS14950	COG1739	Uncharacterized protein family UPF0029
RG49_RS14965	COG0183	Belongs to the thiolase family
RG49_RS14975	COG0543	2 iron, 2 sulfur cluster binding
RG49_RS14980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RG49_RS14985	COG0250	Participates in transcription elongation, termination and antitermination
RG49_RS14990	COG0084	hydrolase, TatD family'
RG49_RS14995	COG0805	protein transport
RG49_RS15000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG49_RS15005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG49_RS15015	COG3165	ubiquinone biosynthetic process from chorismate
RG49_RS15025	COG1322	Protein conserved in bacteria
RG49_RS15035	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RG49_RS15040	COG0412	Dienelactone hydrolase
RG49_RS15050	COG0583	DNA-binding transcription factor activity
RG49_RS15055	COG0697	spore germination
RG49_RS15060	COG0561	phosphatase activity
RG49_RS15065	COG2267	carboxylic ester hydrolase activity
RG49_RS15070	COG1280	lysine exporter protein (LysE YggA)
RG49_RS15075	COG1280	lysine exporter protein (LysE YggA)
RG49_RS15080	COG0514	ATP-dependent DNA helicase (RecQ)
RG49_RS15085	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RG49_RS15090	COG2050	protein possibly involved in aromatic compounds catabolism
RG49_RS15095	COG2962	Rard protein
RG49_RS15110	COG0598	Magnesium transport protein CorA
RG49_RS15120	COG3698	Phosphodiester glycosidase
RG49_RS15125	COG0210	DNA helicase
RG49_RS15130	COG1011	Hydrolase
RG49_RS15140	COG3159	Protein conserved in bacteria
RG49_RS15150	COG5567	small periplasmic lipoprotein
RG49_RS15165	COG3072	Adenylate cyclase
RG49_RS15180	COG1587	Uroporphyrinogen-III synthase
RG49_RS15185	COG2959	enzyme of heme biosynthesis
RG49_RS15190	COG3071	HemY protein
RG49_RS15205	COG0641	radical SAM
RG49_RS15230	COG1113	amino acid transport
RG49_RS15250	COG2244	polysaccharide biosynthetic process
RG49_RS15255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RG49_RS15260	COG0456	acetyltransferase
RG49_RS15265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG49_RS15270	COG1088	dTDP-glucose 4,6-dehydratase activity
RG49_RS15275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RG49_RS15280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RG49_RS15285	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG49_RS15290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RG49_RS15300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RG49_RS15310	COG3118	belongs to the thioredoxin family
RG49_RS15330	COG0210	DNA helicase
RG49_RS15335	COG3692	DNA binding
RG49_RS15340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG49_RS15350	COG0583	DNA-binding transcription factor activity
RG49_RS15355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG49_RS15365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG49_RS15370	COG3978	acetolactate synthase activity
RG49_RS15385	COG0606	chelatase, subunit chli
RG49_RS15390	COG3085	chromosome segregation
RG49_RS15435	COG2186	Transcriptional regulator
RG49_RS15440	COG0477	Major facilitator Superfamily
RG49_RS15445	COG1609	Transcriptional regulator
RG49_RS15450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS15455	COG1879	ABC-type sugar transport system periplasmic component
RG49_RS15460	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG49_RS15465	COG1129	ABC transporter
RG49_RS15495	COG1522	sequence-specific DNA binding
RG49_RS15500	COG0716	FMN binding
RG49_RS15515	COG3312	ion transport
RG49_RS15565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RG49_RS15570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG49_RS15575	COG0573	inorganic phosphate transmembrane transporter activity
RG49_RS15580	COG0581	inorganic phosphate transmembrane transporter activity
RG49_RS15585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RG49_RS15590	COG0704	Plays a role in the regulation of phosphate uptake
RG49_RS15620	COG2382	esterase
RG49_RS15625	COG0363	glucosamine-6-phosphate deaminase activity
RG49_RS15630	COG3196	Protein conserved in bacteria
RG49_RS15640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG49_RS15645	COG2252	PERMEase
RG49_RS15650	COG0431	NADPH-dependent FMN reductase
RG49_RS15655	COG2091	lysine biosynthetic process via aminoadipic acid
RG49_RS15670	COG0814	amino acid
RG49_RS15720	COG0592	DNA-directed DNA polymerase activity
RG49_RS15730	COG0187	DNA topoisomerase II activity
RG49_RS15735	COG3753	Protein conserved in bacteria
RG49_RS15740	COG0561	phosphatase activity
RG49_RS15750	COG2186	Transcriptional regulator
RG49_RS15755	COG3734	2-keto-3-deoxy-galactonokinase
RG49_RS15760	COG0800	Aldolase
RG49_RS15770	COG2271	Major facilitator Superfamily
RG49_RS15775	COG0644	oxidoreductase
RG49_RS15780	COG0823	Involved in the tonB-independent uptake of proteins
RG49_RS15785	COG5645	(Lipo)protein
RG49_RS15805	COG2188	Transcriptional regulator
RG49_RS15825	COG2207	Transcriptional regulator
RG49_RS15830	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG49_RS15835	COG3119	arylsulfatase activity
RG49_RS15845	COG2149	membrane
RG49_RS15855	COG0641	radical SAM
RG49_RS15860	COG2814	Major facilitator Superfamily
RG49_RS15895	COG0028	Belongs to the TPP enzyme family
RG49_RS15900	COG0440	acetolactate synthase activity
RG49_RS15905	COG2197	response regulator
RG49_RS15910	COG3851	Histidine kinase
RG49_RS15915	COG2271	Major facilitator Superfamily
RG49_RS15920	COG2271	Major facilitator Superfamily
RG49_RS15930	COG2252	PERMEase
RG49_RS15965	COG1464	Belongs to the NlpA lipoprotein family
RG49_RS15970	COG0697	spore germination
RG49_RS16080	COG2271	Major facilitator Superfamily
RG49_RS16085	COG1609	Transcriptional regulator
RG49_RS16100	COG0582	viral genome integration into host DNA
RG49_RS16110	COG2211	Major facilitator Superfamily
RG49_RS16115	COG1501	Belongs to the glycosyl hydrolase 31 family
RG49_RS16120	COG2982	Protein involved in outer membrane biogenesis
RG49_RS16125	COG2233	PERMEase
RG49_RS16130	COG0786	glutamate:sodium symporter activity
RG49_RS16135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RG49_RS16140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG49_RS16145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG49_RS16155	COG0194	GDP metabolic process
RG49_RS16165	COG2860	membrane
RG49_RS16170	COG3645	SOS response
RG49_RS16175	COG1561	YicC-like family, N-terminal region
RG49_RS16200	COG0756	dUTP diphosphatase activity
RG49_RS16205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RG49_RS16235	COG1519	Transferase
RG49_RS16240	COG0859	PFAM glycosyl transferase family 9
RG49_RS16245	COG0438	transferase activity, transferring glycosyl groups
RG49_RS16250	COG0515	serine threonine protein kinase
RG49_RS16255	COG0438	transferase activity, transferring glycosyl groups
RG49_RS16255	COG4641	Protein conserved in bacteria
RG49_RS16260	COG0438	transferase activity, transferring glycosyl groups
RG49_RS16265	COG1442	glycosyl transferase family 8
RG49_RS16270	COG1442	glycosyl transferase family 8
RG49_RS16275	COG3642	lipopolysaccharide core region biosynthetic process
RG49_RS16285	COG0859	PFAM glycosyl transferase family 9
RG49_RS16290	COG3307	-O-antigen
RG49_RS16295	COG0859	PFAM glycosyl transferase family 9
RG49_RS16300	COG0859	PFAM glycosyl transferase family 9
RG49_RS16315	COG0156	8-amino-7-oxononanoate synthase activity
RG49_RS16325	COG1216	Glycosyl transferase, family 2
RG49_RS16330	COG2861	carbohydrate metabolic process
RG49_RS16335	COG4942	peptidase
RG49_RS16340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RG49_RS16350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG49_RS16355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG49_RS16370	COG1045	serine acetyltransferase
RG49_RS16375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RG49_RS16385	COG2186	Transcriptional regulator
RG49_RS16390	COG1620	l-lactate permease
RG49_RS16395	COG5295	Hep Hag repeat protein
RG49_RS16420	COG3722	fumarate hydratase activity
RG49_RS16430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS16430	COG2213	PTS system mannitol-specific
RG49_RS16440	COG1566	PFAM secretion protein HlyD family protein
RG49_RS16465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG49_RS16470	COG3209	COG3209 Rhs family protein
RG49_RS16475	COG1413	lyase activity
RG49_RS16480	COG3209	COG3209 Rhs family protein
RG49_RS16490	COG2801	Transposase and inactivated derivatives
RG49_RS16495	COG3209	COG3209 Rhs family protein
RG49_RS16500	COG0625	glutathione transferase activity
RG49_RS16510	COG3276	selenocysteine insertion sequence binding
RG49_RS16515	COG1454	alcohol dehydrogenase
RG49_RS16520	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS16535	COG1566	PFAM secretion protein HlyD family protein
RG49_RS16540	COG0583	DNA-binding transcription factor activity
RG49_RS16565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG49_RS16570	COG2731	YhcH YjgK YiaL family protein
RG49_RS16580	COG1414	Transcriptional regulator
RG49_RS16585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS16590	COG3977	Valine--pyruvate aminotransferase
RG49_RS16595	COG0366	Alpha amylase catalytic
RG49_RS16600	COG2992	FlgJ-related protein
RG49_RS16605	COG1609	Transcriptional regulator
RG49_RS16605	COG2207	Transcriptional regulator
RG49_RS16610	COG4214	carbohydrate transport
RG49_RS16615	COG1129	ABC transporter
RG49_RS16620	COG4213	ABC transporter substrate-binding protein
RG49_RS16645	COG4213	ABC transporter substrate-binding protein
RG49_RS16655	COG1070	Carbohydrate kinase
RG49_RS16660	COG4682	membrane
RG49_RS16665	COG4682	membrane
RG49_RS16670	COG3274	enterobacterial common antigen metabolic process
RG49_RS16690	COG2801	Transposase and inactivated derivatives
RG49_RS16695	COG2963	transposase activity
RG49_RS16705	COG1278	Cold shock
RG49_RS16710	COG2944	sequence-specific DNA binding
RG49_RS16725	COG2885	chlorophyll binding
RG49_RS16730	COG0243	molybdopterin cofactor binding
RG49_RS16735	COG0456	acetyltransferase
RG49_RS16740	COG2818	Glycosylase
RG49_RS16745	COG5571	outer membrane autotransporter
RG49_RS16755	COG2223	nitrite transmembrane transporter activity
RG49_RS16760	COG2194	sulfuric ester hydrolase activity
RG49_RS16775	COG0747	negative chemotaxis
RG49_RS16785	COG0601	transmembrane transport
RG49_RS16790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG49_RS16795	COG0444	Belongs to the ABC transporter superfamily
RG49_RS16800	COG4608	Belongs to the ABC transporter superfamily
RG49_RS16805	COG0814	amino acid
RG49_RS16825	COG2194	sulfuric ester hydrolase activity
RG49_RS16850	COG1215	transferase activity, transferring glycosyl groups
RG49_RS16855	COG1215	transferase activity, transferring glycosyl groups
RG49_RS16860	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RG49_RS16865	COG0457	Tetratricopeptide repeat
RG49_RS16865	COG3118	belongs to the thioredoxin family
RG49_RS16870	COG2200	EAL domain
RG49_RS16870	COG2199	diguanylate cyclase activity
RG49_RS16890	COG0612	Peptidase, M16
RG49_RS16895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS16905	COG2200	EAL domain
RG49_RS16910	COG2982	Protein involved in outer membrane biogenesis
RG49_RS16915	COG0477	Major facilitator Superfamily
RG49_RS16920	COG1295	ribonuclease BN
RG49_RS16925	COG0583	DNA-binding transcription factor activity
RG49_RS16930	COG2197	response regulator
RG49_RS16940	COG1858	cytochrome C peroxidase
RG49_RS16945	COG0076	glutamate decarboxylase activity
RG49_RS16950	COG2207	Transcriptional regulator
RG49_RS16955	COG2207	Transcriptional regulator
RG49_RS16965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG49_RS16970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS16980	COG2771	luxR family
RG49_RS16985	COG3247	response to pH
RG49_RS17000	COG1285	pathogenesis
RG49_RS17005	COG2197	response regulator
RG49_RS17015	COG3065	identical protein binding
RG49_RS17025	COG1393	Belongs to the ArsC family
RG49_RS17030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG49_RS17035	COG0640	Transcriptional regulator
RG49_RS17050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG49_RS17055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RG49_RS17060	COG0339	signal peptide processing
RG49_RS17070	COG3104	oligopeptide transport
RG49_RS17080	COG0589	response to stress
RG49_RS17095	COG0306	phosphate transporter
RG49_RS17100	COG2081	HI0933 family
RG49_RS17130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS17135	COG1129	ABC transporter
RG49_RS17135	COG0842	Transport permease protein
RG49_RS17140	COG0842	Transport permease protein
RG49_RS17145	COG5433	transposase activity
RG49_RS17150	COG1413	lyase activity
RG49_RS17160	COG3209	COG3209 Rhs family protein
RG49_RS17170	COG1124	(ABC) transporter
RG49_RS17175	COG0444	Belongs to the ABC transporter superfamily
RG49_RS17180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG49_RS17185	COG0601	transmembrane transport
RG49_RS17190	COG0747	negative chemotaxis
RG49_RS17195	COG2091	lysine biosynthetic process via aminoadipic acid
RG49_RS17200	COG0628	permease
RG49_RS17205	COG0477	Major facilitator Superfamily
RG49_RS17215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RG49_RS17225	COG2217	Heavy metal translocating P-type atpase
RG49_RS17230	COG3714	YhhN family
RG49_RS17240	COG3776	membrane
RG49_RS17245	COG0742	ribosomal rna small subunit methyltransferase
RG49_RS17250	COG0552	protein localization to endoplasmic reticulum
RG49_RS17255	COG2884	Cell division ATP-binding protein ftsE
RG49_RS17260	COG2177	Part of the ABC transporter FtsEX involved in
RG49_RS17265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG49_RS17270	COG0683	leucine binding
RG49_RS17275	COG0456	acetyltransferase
RG49_RS17285	COG0683	leucine binding
RG49_RS17290	COG0559	Belongs to the binding-protein-dependent transport system permease family
RG49_RS17295	COG4177	L-phenylalanine transmembrane transporter activity
RG49_RS17300	COG0411	ABC transporter
RG49_RS17305	COG0410	ABC transporter
RG49_RS17315	COG1653	transport
RG49_RS17320	COG1175	transmembrane transport
RG49_RS17325	COG0395	ABC-type sugar transport system, permease component
RG49_RS17330	COG3842	ATPase activity
RG49_RS17335	COG0584	glycerophosphoryl diester phosphodiesterase
RG49_RS17345	COG0405	Gamma-glutamyltransferase
RG49_RS17365	COG3157	Type VI secretion system effector, Hcp
RG49_RS17370	COG1247	-acetyltransferase
RG49_RS17375	COG0673	inositol 2-dehydrogenase activity
RG49_RS17380	COG1741	Belongs to the pirin family
RG49_RS17385	COG1609	Transcriptional regulator
RG49_RS17390	COG3265	gluconokinase activity
RG49_RS17395	COG2610	gluconate transmembrane transporter activity
RG49_RS17400	COG2095	MarC family integral membrane protein
RG49_RS17405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG49_RS17430	COG0058	SHG alpha-glucan phosphorylase activity
RG49_RS17435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG49_RS17440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG49_RS17455	COG1349	DNA-binding transcription factor activity
RG49_RS17460	COG4650	regulator
RG49_RS17465	COG1690	Belongs to the RtcB family
RG49_RS17480	COG0058	SHG alpha-glucan phosphorylase activity
RG49_RS17485	COG1640	4-alpha-glucanotransferase
RG49_RS17490	COG2610	gluconate transmembrane transporter activity
RG49_RS17500	COG1040	competence protein
RG49_RS17510	COG5464	transposase or invertase
RG49_RS17525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RG49_RS17530	COG1918	ferrous iron import across plasma membrane
RG49_RS17540	COG2183	response to ionizing radiation
RG49_RS17545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG49_RS17575	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG49_RS17585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RG49_RS17590	COG1011	Hydrolase
RG49_RS17600	COG0494	nUDIX hydrolase
RG49_RS17605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RG49_RS17610	COG4972	Pilus assembly protein
RG49_RS17615	COG3166	PFAM Fimbrial assembly family protein
RG49_RS17630	COG4796	Type ii and iii secretion system protein
RG49_RS17645	COG3266	domain, Protein
RG49_RS17650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RG49_RS17655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG49_RS17660	COG0546	phosphoglycolate phosphatase activity
RG49_RS17665	COG0180	Tryptophanyl-tRNA synthetase
RG49_RS17675	COG2188	Transcriptional regulator
RG49_RS17685	COG3457	Alanine racemase
RG49_RS17690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RG49_RS17695	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RG49_RS17710	COG0626	cystathionine gamma-synthase activity
RG49_RS17715	COG2188	Transcriptional regulator
RG49_RS17720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS17725	COG1082	Xylose isomerase domain protein TIM barrel
RG49_RS17730	COG1082	Xylose isomerase domain protein TIM barrel
RG49_RS17735	COG2222	sugar isomerase
RG49_RS17740	COG0531	amino acid
RG49_RS17755	COG2116	formate transmembrane transporter activity
RG49_RS17760	COG2146	nitrite reductase [NAD(P)H] activity
RG49_RS17765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG49_RS17775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG49_RS17785	COG2184	nucleotidyltransferase activity
RG49_RS17790	COG0512	Glutamine amidotransferase of anthranilate synthase
RG49_RS17795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RG49_RS17800	COG1289	transmembrane transporter activity
RG49_RS17805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG49_RS17815	COG1765	OsmC-like protein
RG49_RS17820	COG3954	Phosphoribulokinase
RG49_RS17830	COG0429	hydrolase of the alpha beta-hydrolase fold
RG49_RS17835	COG0488	(ABC) transporter
RG49_RS17855	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RG49_RS17860	COG1047	Peptidyl-prolyl cis-trans
RG49_RS17870	COG0545	Peptidyl-prolyl cis-trans isomerase
RG49_RS17875	COG2964	Protein conserved in bacteria
RG49_RS17915	COG3979	chitinase
RG49_RS17920	COG2906	2 iron, 2 sulfur cluster binding
RG49_RS17925	COG2193	ferroxidase activity
RG49_RS17930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RG49_RS17935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG49_RS17940	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG49_RS17945	COG3156	type II secretion system protein K
RG49_RS17950	COG4795	General secretion pathway protein
RG49_RS17955	COG2165	general secretion pathway protein
RG49_RS17960	COG2165	general secretion pathway protein
RG49_RS17970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG49_RS17975	COG1450	Type ii and iii secretion system protein
RG49_RS17980	COG3031	protein transport across the cell outer membrane
RG49_RS17985	COG3409	Peptidoglycan-binding domain 1 protein
RG49_RS17985	COG3267	Type II secretory pathway component ExeA
RG49_RS18010	COG0089	rRNA binding
RG49_RS18100	COG0201	protein transport
RG49_RS18140	COG0789	Transcriptional regulator
RG49_RS18145	COG3036	rescue of stalled ribosome
RG49_RS18155	COG0569	domain protein
RG49_RS18175	COG0758	DNA mediated transformation
RG49_RS18185	COG0551	DNA topoisomerase type I activity
RG49_RS18205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG49_RS18245	COG1126	abc transporter atp-binding protein
RG49_RS18250	COG0765	amino acid transport
RG49_RS18255	COG4597	amino acid ABC transporter
RG49_RS18260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS18270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG49_RS18275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG49_RS18285	COG1309	transcriptional regulator
RG49_RS18295	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RG49_RS18305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG49_RS18315	COG4145	pantothenate transmembrane transporter activity
RG49_RS18320	COG3924	membrane
RG49_RS18325	COG0439	Biotin carboxylase
RG49_RS18330	COG0511	ligase activity, forming carbon-carbon bonds
RG49_RS18345	COG0604	alcohol dehydrogenase
RG49_RS18350	COG2200	EAL domain
RG49_RS18350	COG2199	diguanylate cyclase activity
RG49_RS18365	COG1077	Cell shape determining protein MreB Mrl
RG49_RS18370	COG1792	Involved in formation and maintenance of cell shape
RG49_RS18375	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RG49_RS18380	COG0424	maF-like protein
RG49_RS18385	COG1530	ribonuclease E activity
RG49_RS18390	COG3164	Protein of unknown function
RG49_RS18400	COG0312	modulator of DNA gyrase
RG49_RS18405	COG0583	DNA-binding transcription factor activity
RG49_RS18425	COG2732	(Barnase) inhibitor
RG49_RS18445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG49_RS18450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG49_RS18455	COG3105	Protein conserved in bacteria
RG49_RS18460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RG49_RS18475	COG0625	glutathione transferase activity
RG49_RS18480	COG2969	positive regulation of protein catabolic process
RG49_RS18485	COG3069	C4-dicarboxylate transmembrane transporter activity
RG49_RS18520	COG2731	YhcH YjgK YiaL family protein
RG49_RS18525	COG4804	nuclease activity
RG49_RS18530	COG3539	Fimbrial protein
RG49_RS18540	COG3188	usher protein
RG49_RS18545	COG3121	Chaperone
RG49_RS18550	COG3539	Fimbrial protein
RG49_RS18565	COG0493	'glutamate synthase
RG49_RS18570	COG0069	glutamate synthase activity
RG49_RS18570	COG0070	glutamate synthase
RG49_RS18570	COG0067	glutamate synthase
RG49_RS18585	COG1242	4 iron, 4 sulfur cluster binding
RG49_RS18590	COG5002	protein histidine kinase activity
RG49_RS18590	COG2198	Histidine kinase
RG49_RS18590	COG0784	Response regulator, receiver
RG49_RS18595	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RG49_RS18605	COG0515	serine threonine protein kinase
RG49_RS18610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS18625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG49_RS18630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RG49_RS18635	COG1137	ATPase activity
RG49_RS18640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RG49_RS18645	COG3117	lipopolysaccharide transmembrane transporter activity
RG49_RS18650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RG49_RS18655	COG0517	IMP dehydrogenase activity
RG49_RS18655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG49_RS18660	COG0530	calcium, potassium:sodium antiporter activity
RG49_RS18665	COG1127	ABC transporter
RG49_RS18670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RG49_RS18675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG49_RS18680	COG2854	intermembrane phospholipid transfer
RG49_RS18685	COG3113	response to antibiotic
RG49_RS18690	COG5007	Belongs to the BolA IbaG family
RG49_RS18700	COG3423	Transcriptional regulator
RG49_RS18705	COG0142	geranyltranstransferase activity
RG49_RS18720	COG0697	spore germination
RG49_RS18730	COG2027	D-alanyl-D-alanine carboxypeptidase
RG49_RS18735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG49_RS18740	COG1534	Rna-binding protein
RG49_RS18750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG49_RS18755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RG49_RS18765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG49_RS18780	COG2194	sulfuric ester hydrolase activity
RG49_RS18800	COG0195	Participates in both transcription termination and antitermination
RG49_RS18840	COG0513	Belongs to the DEAD box helicase family
RG49_RS18850	COG0814	amino acid
RG49_RS18855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RG49_RS18860	COG0826	peptidase U32
RG49_RS18865	COG0826	peptidase U32
RG49_RS18870	COG3154	lipid carrier protein
RG49_RS18875	COG3153	acetyltransferase
RG49_RS18890	COG0693	protein deglycase activity
RG49_RS18895	COG0702	epimerase
RG49_RS18900	COG0701	Predicted permease
RG49_RS18905	COG2823	Periplasmic or secreted lipoprotein
RG49_RS18920	COG3107	peptidoglycan biosynthetic process
RG49_RS18925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RG49_RS18930	COG3539	Fimbrial protein
RG49_RS18935	COG3188	usher protein
RG49_RS18940	COG3121	Chaperone
RG49_RS18945	COG3539	Fimbrial protein
RG49_RS18950	COG0363	glucosamine-6-phosphate deaminase activity
RG49_RS18955	COG3716	PTS system mannose fructose sorbose family IID component
RG49_RS18960	COG3715	PTS system
RG49_RS18965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS18975	COG2222	sugar isomerase
RG49_RS18980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG49_RS18985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS18990	COG3716	PTS system mannose fructose sorbose family IID component
RG49_RS19000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS19015	COG1349	DNA-binding transcription factor activity
RG49_RS19025	COG2002	toxin-antitoxin pair type II binding
RG49_RS19030	COG2721	sulfolactate sulfo-lyase activity
RG49_RS19035	COG2271	Major facilitator Superfamily
RG49_RS19045	COG2084	Dehydrogenase
RG49_RS19050	COG1929	Belongs to the glycerate kinase type-1 family
RG49_RS19085	COG2801	Transposase and inactivated derivatives
RG49_RS19090	COG2963	transposase activity
RG49_RS19095	COG2826	transposase and inactivated derivatives, IS30 family
RG49_RS19100	COG2963	transposase activity
RG49_RS19120	COG0583	DNA-binding transcription factor activity
RG49_RS19125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG49_RS19135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG49_RS19140	COG1882	Formate acetyltransferase
RG49_RS19145	COG0251	oxidation-reduction process
RG49_RS19150	COG1760	l-serine dehydratase
RG49_RS19155	COG0814	amino acid
RG49_RS19170	COG1741	Belongs to the pirin family
RG49_RS19175	COG0583	DNA-binding transcription factor activity
RG49_RS19185	COG3152	Membrane
RG49_RS19190	COG3152	Membrane
RG49_RS19195	COG0435	Glutathione S-transferase
RG49_RS19200	COG2259	Doxx family
RG49_RS19210	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
RG49_RS19215	COG4575	ribosome binding
RG49_RS19220	COG1422	Protein of unknown function (DUF1090)
RG49_RS19230	COG0586	Pfam SNARE associated Golgi protein
RG49_RS19235	COG2186	Transcriptional regulator
RG49_RS19240	COG2271	Major facilitator Superfamily
RG49_RS19250	COG2721	sulfolactate sulfo-lyase activity
RG49_RS19260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RG49_RS19265	COG0861	Integral membrane protein TerC family
RG49_RS19270	COG0673	inositol 2-dehydrogenase activity
RG49_RS19275	COG2949	membrane
RG49_RS19280	COG1451	nucleotide metabolic process
RG49_RS19295	COG4680	protein conserved in bacteria
RG49_RS19300	COG5499	transcription regulator containing HTH domain
RG49_RS19305	COG0446	pyridine nucleotide-disulphide oxidoreductase
RG49_RS19305	COG1902	pentaerythritol trinitrate reductase activity
RG49_RS19310	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RG49_RS19310	COG3408	Glycogen debranching enzyme
RG49_RS19320	COG0531	amino acid
RG49_RS19325	COG2731	YhcH YjgK YiaL family protein
RG49_RS19330	COG3250	beta-galactosidase activity
RG49_RS19335	COG1609	Transcriptional regulator
RG49_RS19345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG49_RS19360	COG0840	transmembrane signaling receptor activity
RG49_RS19365	COG1695	Transcriptional regulator
RG49_RS19375	COG2375	cellular response to nickel ion
RG49_RS19390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG49_RS19400	COG0358	DNA primase activity
RG49_RS19405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RG49_RS19420	COG0471	metal ion transport
RG49_RS19425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG49_RS19430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG49_RS19450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG49_RS19465	COG4991	sh3 domain protein
RG49_RS19475	COG3025	triphosphatase activity
RG49_RS19500	COG2268	Band 7 protein
RG49_RS19505	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG49_RS19515	COG3539	Fimbrial protein
RG49_RS19520	COG3121	Chaperone
RG49_RS19525	COG3188	usher protein
RG49_RS19530	COG3539	Fimbrial protein
RG49_RS19535	COG2960	long-chain fatty acid transporting porin activity
RG49_RS19555	COG3384	dioxygenase
RG49_RS19560	COG0754	glutathionylspermidine amidase activity
RG49_RS19575	COG1538	Outer membrane efflux protein
RG49_RS19580	COG0494	nUDIX hydrolase
RG49_RS19585	COG3151	Protein conserved in bacteria
RG49_RS19590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RG49_RS19595	COG3150	esterase
RG49_RS19600	COG0187	DNA topoisomerase II activity
RG49_RS19605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RG49_RS19610	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG49_RS19620	COG0642	Histidine kinase
RG49_RS19625	COG0745	RESPONSE REGULATOR receiver
RG49_RS19630	COG3111	PFAM Bacterial OB fold (BOF) protein
RG49_RS19635	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG49_RS19645	COG2944	sequence-specific DNA binding
RG49_RS19650	COG4166	transmembrane transport
RG49_RS19655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG49_RS19665	COG0204	Acyl-transferase
RG49_RS19670	COG2132	Multicopper oxidase
RG49_RS19675	COG1032	radical SAM domain protein
RG49_RS19680	COG4238	major outer membrane lipoprotein
RG49_RS19690	COG0656	L-ascorbic acid biosynthetic process
RG49_RS19695	COG1979	alcohol dehydrogenase
RG49_RS19705	COG2207	Transcriptional regulator
RG49_RS19710	COG0586	Pfam SNARE associated Golgi protein
RG49_RS19715	COG0626	cystathionine gamma-synthase activity
RG49_RS19725	COG0811	peptide transport
RG49_RS19730	COG0848	biopolymer transport protein
RG49_RS19740	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS19750	COG0667	Aldo Keto reductase
RG49_RS19775	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG49_RS19780	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS19785	COG5557	Pfam Polysulphide reductase, NrfD
RG49_RS19790	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG49_RS19795	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG49_RS19800	COG1773	rubredoxin
RG49_RS19810	COG0298	carbon dioxide binding
RG49_RS19815	COG0625	glutathione transferase activity
RG49_RS19820	COG0754	glutathionylspermidine amidase activity
RG49_RS19825	COG0306	phosphate transporter
RG49_RS19830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG49_RS19835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG49_RS19840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG49_RS19845	COG2244	polysaccharide biosynthetic process
RG49_RS19855	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG49_RS19860	COG0795	lipopolysaccharide-transporting ATPase activity
RG49_RS19870	COG0156	8-amino-7-oxononanoate synthase activity
RG49_RS19875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RG49_RS19885	COG0318	PFAM AMP-dependent synthetase and ligase
RG49_RS19890	COG0456	acetyltransferase
RG49_RS19895	COG2186	Transcriptional regulator
RG49_RS19900	COG0277	FAD linked oxidase domain protein
RG49_RS19905	COG0277	FAD linked oxidase domain protein
RG49_RS19910	COG0247	lactate metabolic process
RG49_RS19915	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RG49_RS19920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG49_RS19925	COG1620	l-lactate permease
RG49_RS19950	COG0598	Magnesium transport protein CorA
RG49_RS19960	COG3698	Phosphodiester glycosidase
RG49_RS19995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG49_RS20000	COG1459	type II secretion system
RG49_RS20005	COG2165	general secretion pathway protein
RG49_RS20035	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG49_RS20045	COG1811	Na channel or pump
RG49_RS20055	COG1982	Orn Lys Arg decarboxylase major
RG49_RS20060	COG2211	Major facilitator Superfamily
RG49_RS20075	COG1194	a g-specific adenine glycosylase
RG49_RS20090	COG3171	Protein conserved in bacteria
RG49_RS20100	COG0252	asparaginase activity
RG49_RS20110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG49_RS20125	COG0762	integral membrane protein
RG49_RS20130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RG49_RS20135	COG2805	Type II/IV secretion system protein
RG49_RS20150	COG0189	ligase activity
RG49_RS20155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RG49_RS20160	COG2356	endonuclease I
RG49_RS20170	COG2814	Major facilitator Superfamily
RG49_RS20200	COG1166	arginine decarboxylase activity
RG49_RS20210	COG0501	Belongs to the peptidase M48B family
RG49_RS20215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG49_RS20220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS20225	COG2213	PTS system mannitol-specific
RG49_RS20230	COG1063	alcohol dehydrogenase
RG49_RS20235	COG1494	fructose-1,6-bisphosphatase
RG49_RS20240	COG3722	fumarate hydratase activity
RG49_RS20245	COG1072	(Pantothenic acid kinase))
RG49_RS20265	COG0191	fructose-bisphosphate aldolase activity
RG49_RS20270	COG0668	transmembrane transport
RG49_RS20275	COG1279	arginine transmembrane transporter activity
RG49_RS20280	COG2968	Membrane
RG49_RS20285	COG0583	DNA-binding transcription factor activity
RG49_RS20290	COG0427	acetyl-CoA hydrolase
RG49_RS20295	COG1024	Enoyl-CoA hydratase
RG49_RS20300	COG1703	isobutyryl-CoA mutase activity
RG49_RS20305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG49_RS20305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG49_RS20330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RG49_RS20340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RG49_RS20365	COG0006	proline dipeptidase activity
RG49_RS20370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG49_RS20375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG49_RS20395	COG2723	6-phospho-beta-galactosidase activity
RG49_RS20405	COG1272	protein, Hemolysin III
RG49_RS20415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RG49_RS20425	COG0716	FMN binding
RG49_RS20430	COG4974	Belongs to the 'phage' integrase family
RG49_RS20435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG49_RS20440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RG49_RS20450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG49_RS20465	COG2233	PERMEase
RG49_RS20475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS20475	COG0493	'glutamate synthase
RG49_RS20480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS20485	COG2252	PERMEase
RG49_RS20490	COG0402	S-adenosylhomocysteine deaminase activity
RG49_RS20495	COG2233	PERMEase
RG49_RS20500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG49_RS20500	COG2080	2 iron, 2 sulfur cluster binding
RG49_RS20505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG49_RS20510	COG0402	S-adenosylhomocysteine deaminase activity
RG49_RS20515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS20515	COG0493	'glutamate synthase
RG49_RS20520	COG2068	MobA-Related Protein
RG49_RS20525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG49_RS20530	COG3608	succinylglutamate desuccinylase aspartoacylase
RG49_RS20530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG49_RS20540	COG0549	Belongs to the carbamate kinase family
RG49_RS20550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG49_RS20555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG49_RS20560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RG49_RS20565	COG3829	transcription factor binding
RG49_RS20570	COG2080	2 iron, 2 sulfur cluster binding
RG49_RS20575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG49_RS20580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG49_RS20590	COG4942	peptidase
RG49_RS20620	COG3387	PFAM Glycoside hydrolase 15-related
RG49_RS20710	COG2197	response regulator
RG49_RS20715	COG2197	response regulator
RG49_RS20730	COG3710	Transcriptional regulator
RG49_RS20730	COG0457	Tetratricopeptide repeat
RG49_RS20740	COG0457	Tetratricopeptide repeat
RG49_RS20765	COG3710	Transcriptional regulator
RG49_RS20795	COG2771	luxR family
RG49_RS20800	COG0814	amino acid
RG49_RS20805	COG0183	Belongs to the thiolase family
RG49_RS20815	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS20820	COG2814	Major facilitator Superfamily
RG49_RS20825	COG1794	racemase activity, acting on amino acids and derivatives
RG49_RS20830	COG0583	DNA-binding transcription factor activity
RG49_RS20840	COG1609	Transcriptional regulator
RG49_RS20860	COG0667	Aldo Keto reductase
RG49_RS20870	COG0861	Integral membrane protein TerC family
RG49_RS20895	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
RG49_RS20910	COG2165	general secretion pathway protein
RG49_RS20915	COG4795	General secretion pathway protein
RG49_RS20925	COG4967	type IV pilus modification protein PilV
RG49_RS20930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RG49_RS20935	COG1025	Belongs to the peptidase M16 family
RG49_RS20940	COG1074	ATP-dependent DNA helicase activity
RG49_RS20945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RG49_RS20950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RG49_RS20950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RG49_RS20955	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG49_RS20980	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RG49_RS20985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RG49_RS20990	COG2166	iron-sulfur cluster assembly
RG49_RS20995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RG49_RS21005	COG0583	DNA-binding transcription factor activity
RG49_RS21010	COG2363	Small membrane protein
RG49_RS21020	COG1349	DNA-binding transcription factor activity
RG49_RS21030	COG1070	Carbohydrate kinase
RG49_RS21040	COG0738	Major facilitator superfamily
RG49_RS21045	COG0235	Class ii aldolase
RG49_RS21050	COG1454	alcohol dehydrogenase
RG49_RS21060	COG1760	l-serine dehydratase
RG49_RS21065	COG0814	amino acid
RG49_RS21070	COG1611	Belongs to the LOG family
RG49_RS21090	COG3098	single-species biofilm formation
RG49_RS21095	COG0564	pseudouridine synthase activity
RG49_RS21100	COG0716	FMN binding
RG49_RS21105	COG2271	Major facilitator Superfamily
RG49_RS21110	COG4948	Mandelate Racemase Muconate Lactonizing
RG49_RS21115	COG4948	Mandelate Racemase Muconate Lactonizing
RG49_RS21120	COG3437	response regulator, receiver
RG49_RS21120	COG2205	protein histidine kinase activity
RG49_RS21120	COG3850	Histidine kinase
RG49_RS21120	COG4999	Histidine kinase
RG49_RS21130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG49_RS21135	COG2336	PFAM SpoVT AbrB
RG49_RS21140	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG49_RS21145	COG3956	TIGRFAM MazG family protein
RG49_RS21160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG49_RS21170	COG0602	queuosine metabolic process
RG49_RS21175	COG1070	Carbohydrate kinase
RG49_RS21180	COG2223	nitrite transmembrane transporter activity
RG49_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS21190	COG0277	FAD linked oxidase domain protein
RG49_RS21195	COG0477	Major facilitator Superfamily
RG49_RS21200	COG2086	electron transfer activity
RG49_RS21205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG49_RS21210	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RG49_RS21215	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG49_RS21220	COG0644	oxidoreductase
RG49_RS21225	COG0720	synthase
RG49_RS21235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG49_RS21255	COG3385	transposase activity
RG49_RS21280	COG1857	crispr-associated protein
RG49_RS21295	COG1518	maintenance of DNA repeat elements
RG49_RS21300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG49_RS21305	COG2234	aminopeptidase activity
RG49_RS21360	COG4942	peptidase
RG49_RS21360	COG1388	LysM domain
RG49_RS21365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG49_RS21370	COG2610	gluconate transmembrane transporter activity
RG49_RS21375	COG3622	Belongs to the hyi family
RG49_RS21380	COG0235	Class ii aldolase
RG49_RS21385	COG3395	kinase activity
RG49_RS21390	COG2084	Dehydrogenase
RG49_RS21395	COG1349	DNA-binding transcription factor activity
RG49_RS21400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG49_RS21420	COG3604	Transcriptional regulator
RG49_RS21425	COG0309	Hydrogenase expression formation protein (HypE)
RG49_RS21430	COG0409	Hydrogenase expression formation protein
RG49_RS21435	COG0298	carbon dioxide binding
RG49_RS21440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RG49_RS21445	COG0375	protein maturation
RG49_RS21460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS21465	COG0651	ATP synthesis coupled electron transport
RG49_RS21470	COG0650	Formate hydrogenlyase subunit 4
RG49_RS21475	COG3261	NADH dehydrogenase
RG49_RS21475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG49_RS21480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG49_RS21485	COG3260	NADH ubiquinone oxidoreductase 20
RG49_RS21495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG49_RS21500	COG2723	6-phospho-beta-galactosidase activity
RG49_RS21505	COG1263	PTS System
RG49_RS21505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS21510	COG1609	Transcriptional regulator
RG49_RS21515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS21520	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RG49_RS21545	COG0517	IMP dehydrogenase activity
RG49_RS21545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG49_RS21550	COG1349	DNA-binding transcription factor activity
RG49_RS21555	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS21560	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS21565	COG3731	PTS system glucitol sorbitol-specific IIA component
RG49_RS21570	COG3732	PTS system glucitol sorbitol-specific
RG49_RS21575	COG3730	PTS system glucitol sorbitol-specific
RG49_RS21580	COG2951	lytic endotransglycosylase activity
RG49_RS21585	COG1546	Belongs to the CinA family
RG49_RS21610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RG49_RS21640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG49_RS21645	COG1238	metal cluster binding
RG49_RS21660	COG2814	Major facilitator Superfamily
RG49_RS21665	COG1566	PFAM secretion protein HlyD family protein
RG49_RS21670	COG1846	Transcriptional regulator
RG49_RS21680	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RG49_RS21685	COG2814	Major facilitator Superfamily
RG49_RS21690	COG2113	Glycine betaine
RG49_RS21695	COG4176	ABC-type proline glycine betaine transport system permease component
RG49_RS21700	COG4175	Glycine betaine
RG49_RS21710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG49_RS21715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG49_RS21725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG49_RS21730	COG4575	ribosome binding
RG49_RS21745	COG2916	Histone family protein nucleoid-structuring protein H-NS
RG49_RS21750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG49_RS21755	COG0640	Transcriptional regulator
RG49_RS21760	COG0401	homolog of Blt101
RG49_RS21765	COG1652	LysM domain
RG49_RS21770	COG1802	Transcriptional regulator
RG49_RS21775	COG1113	amino acid transport
RG49_RS21780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG49_RS21785	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS21790	COG0579	oxidoreductase
RG49_RS21800	COG0366	Alpha amylase catalytic
RG49_RS21805	COG0366	Alpha amylase catalytic
RG49_RS21815	COG0366	Alpha amylase catalytic
RG49_RS21850	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS21855	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS21920	COG0582	viral genome integration into host DNA
RG49_RS21935	COG2867	negative regulation of translational initiation
RG49_RS21945	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG49_RS21950	COG0497	DNA recombination
RG49_RS21970	COG4536	flavin adenine dinucleotide binding
RG49_RS21975	COG4137	Cytochrome C assembly protein
RG49_RS21980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RG49_RS22005	COG2885	chlorophyll binding
RG49_RS22010	COG2199	diguanylate cyclase activity
RG49_RS22025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG49_RS22030	COG0287	Prephenate dehydrogenase
RG49_RS22030	COG1605	Chorismate mutase
RG49_RS22035	COG0077	Prephenate dehydratase
RG49_RS22035	COG1605	Chorismate mutase
RG49_RS22040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG49_RS22050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG49_RS22055	COG0564	pseudouridine synthase activity
RG49_RS22060	COG1496	oxidoreductase activity
RG49_RS22065	COG0542	response to heat
RG49_RS22100	COG0477	Major facilitator Superfamily
RG49_RS22105	COG5544	Lipoprotein
RG49_RS22110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG49_RS22115	COG1042	CoA-binding domain protein
RG49_RS22115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG49_RS22115	COG0045	succinate-CoA ligase (ADP-forming) activity
RG49_RS22120	COG3148	PFAM DTW domain containing protein
RG49_RS22125	COG3118	belongs to the thioredoxin family
RG49_RS22130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG49_RS22150	COG0583	DNA-binding transcription factor activity
RG49_RS22155	COG0513	Belongs to the DEAD box helicase family
RG49_RS22165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG49_RS22175	COG1595	DNA-templated transcription, initiation
RG49_RS22180	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RG49_RS22185	COG3026	antisigma factor binding
RG49_RS22190	COG3086	response to oxidative stress
RG49_RS22200	COG0681	Belongs to the peptidase S26 family
RG49_RS22225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RG49_RS22250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS22255	COG1737	Transcriptional regulator
RG49_RS22260	COG0560	Phosphoserine phosphatase
RG49_RS22280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RG49_RS22280	COG0047	phosphoribosylformylglycinamidine synthase activity
RG49_RS22285	COG2205	protein histidine kinase activity
RG49_RS22290	COG3170	Tfp pilus assembly protein FimV
RG49_RS22295	COG2204	response regulator
RG49_RS22300	COG0347	Belongs to the P(II) protein family
RG49_RS22305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG49_RS22305	COG1017	nitric oxide dioxygenase activity
RG49_RS22325	COG0457	Tetratricopeptide repeat
RG49_RS22330	COG1879	ABC-type sugar transport system periplasmic component
RG49_RS22335	COG1129	ABC transporter
RG49_RS22340	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG49_RS22345	COG1063	alcohol dehydrogenase
RG49_RS22350	COG2017	converts alpha-aldose to the beta-anomer
RG49_RS22355	COG2259	Doxx family
RG49_RS22380	COG4638	Rieske (2fe-2S)
RG49_RS22385	COG0583	DNA-binding transcription factor activity
RG49_RS22390	COG2814	Major facilitator Superfamily
RG49_RS22395	COG3711	transcriptional antiterminator
RG49_RS22400	COG1073	alpha beta
RG49_RS22405	COG0483	inositol monophosphate 1-phosphatase activity
RG49_RS22425	COG0822	iron-sulfur transferase activity
RG49_RS22445	COG0633	Ferredoxin
RG49_RS22450	COG2975	iron-sulfur cluster assembly
RG49_RS22465	COG2897	thiosulfate sulfurtransferase activity
RG49_RS22470	COG2373	Large extracellular alpha-helical protein
RG49_RS22475	COG4953	penicillin-binding protein 1C
RG49_RS22505	COG2976	Protein conserved in bacteria
RG49_RS22520	COG1645	bacterial-type flagellum-dependent swarming motility
RG49_RS22530	COG0517	IMP dehydrogenase activity
RG49_RS22530	COG0516	GMP reductase activity
RG49_RS22540	COG0582	viral genome integration into host DNA
RG49_RS22580	COG3846	protein secretion by the type IV secretion system
RG49_RS22585	COG3093	addiction module antidote protein HigA
RG49_RS22590	COG1002	Type II restriction enzyme, methylase subunits
RG49_RS22595	COG1061	Type III restriction enzyme res subunit
RG49_RS22600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG49_RS22610	COG3133	Outer membrane lipoprotein
RG49_RS22630	COG2200	EAL domain
RG49_RS22635	COG0248	Ppx GppA phosphatase
RG49_RS22640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RG49_RS22645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RG49_RS22665	COG2233	PERMEase
RG49_RS22675	COG1393	Belongs to the ArsC family
RG49_RS22680	COG4783	chaperone-mediated protein folding
RG49_RS22685	COG0628	permease
RG49_RS22690	COG2116	formate transmembrane transporter activity
RG49_RS22695	COG3604	Transcriptional regulator
RG49_RS22705	COG3260	NADH ubiquinone oxidoreductase 20
RG49_RS22710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG49_RS22715	COG3261	NADH dehydrogenase
RG49_RS22715	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG49_RS22720	COG0651	ATP synthesis coupled electron transport
RG49_RS22725	COG4237	Hydrogenase 4 membrane
RG49_RS22730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG49_RS22735	COG0650	Formate hydrogenlyase subunit 4
RG49_RS22740	COG0651	ATP synthesis coupled electron transport
RG49_RS22745	COG0651	ATP synthesis coupled electron transport
RG49_RS22750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS22755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RG49_RS22760	COG2716	regulation of RNA biosynthetic process
RG49_RS22770	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RG49_RS22785	COG2321	neutral zinc metallopeptidase
RG49_RS22790	COG1444	tRNA N-acetyltransferase activity
RG49_RS22795	COG0400	carboxylic ester hydrolase activity
RG49_RS22810	COG1393	Belongs to the ArsC family
RG49_RS22820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG49_RS22825	COG3850	Histidine kinase
RG49_RS22830	COG0493	'glutamate synthase
RG49_RS22830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS22840	COG5342	invasion associated locus B
RG49_RS22845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG49_RS22850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG49_RS22855	COG0280	phosphate acetyltransferase
RG49_RS22855	COG0281	malic enzyme
RG49_RS22860	COG4810	utilization protein
RG49_RS22865	COG4917	ethanolamine utilization protein
RG49_RS22870	COG4766	ethanolamine catabolic process
RG49_RS22875	COG4812	Cobalamin adenosyltransferase
RG49_RS22880	COG0280	phosphate acetyltransferase
RG49_RS22885	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG49_RS22890	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RG49_RS22895	COG1012	belongs to the aldehyde dehydrogenase family
RG49_RS22900	COG4820	ethanolamine utilization protein (EutJ)
RG49_RS22905	COG1454	alcohol dehydrogenase
RG49_RS22910	COG3192	ethanolamine utilization protein
RG49_RS22915	COG4819	ethanolamine utilization protein
RG49_RS22920	COG4303	Ethanolamine ammonia lyase large subunit
RG49_RS22930	COG4816	utilization protein
RG49_RS22935	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG49_RS22940	COG2207	Transcriptional regulator
RG49_RS22950	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG49_RS22955	COG0456	acetyltransferase
RG49_RS22970	COG2837	iron assimilation
RG49_RS22975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG49_RS22980	COG1263	PTS System
RG49_RS22980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG49_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS23000	COG4150	thiosulfate binding
RG49_RS23005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RG49_RS23010	COG4208	sulfate ABC transporter
RG49_RS23015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RG49_RS23020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG49_RS23025	COG3831	ATPase activity
RG49_RS23025	COG4884	unkown
RG49_RS23040	COG2190	(PTS) system
RG49_RS23045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG49_RS23050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS23055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG49_RS23080	COG3530	Putative quorum-sensing-regulated virulence factor
RG49_RS23085	COG0385	Bile acid
RG49_RS23090	COG0583	DNA-binding transcription factor activity
RG49_RS23100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RG49_RS23105	COG2211	Major facilitator Superfamily
RG49_RS23115	COG0583	DNA-binding transcription factor activity
RG49_RS23150	COG3415	Transposase
RG49_RS23155	COG3415	Transposase
RG49_RS23170	COG2200	EAL domain
RG49_RS23170	COG2199	diguanylate cyclase activity
RG49_RS23175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG49_RS23205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS23210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS23215	COG0006	proline dipeptidase activity
RG49_RS23220	COG1363	Peptidase, m42
RG49_RS23225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG49_RS23225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS23225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS23230	COG2207	Transcriptional regulator
RG49_RS23235	COG3279	Response regulator of the LytR AlgR family
RG49_RS23240	COG3275	phosphorelay sensor kinase activity
RG49_RS23245	COG0436	Aminotransferase
RG49_RS23255	COG1560	Kdo2-lipid A biosynthetic process
RG49_RS23285	COG0028	Belongs to the TPP enzyme family
RG49_RS23290	COG0679	Auxin Efflux Carrier
RG49_RS23295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RG49_RS23300	COG2198	Histidine kinase
RG49_RS23300	COG2205	protein histidine kinase activity
RG49_RS23300	COG0784	Response regulator, receiver
RG49_RS23300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS23305	COG2197	response regulator
RG49_RS23310	COG1566	PFAM secretion protein HlyD family protein
RG49_RS23315	COG0477	Major facilitator Superfamily
RG49_RS23325	COG2610	gluconate transmembrane transporter activity
RG49_RS23330	COG0583	DNA-binding transcription factor activity
RG49_RS23340	COG2116	formate transmembrane transporter activity
RG49_RS23345	COG2853	Lipoprotein
RG49_RS23355	COG2067	long-chain fatty acid transport protein
RG49_RS23365	COG3691	Protein conserved in bacteria
RG49_RS23380	COG2062	phosphohistidine phosphatase, SixA
RG49_RS23385	COG3539	Fimbrial protein
RG49_RS23390	COG3188	usher protein
RG49_RS23395	COG3121	Chaperone
RG49_RS23400	COG3539	Fimbrial protein
RG49_RS23405	COG3539	Fimbrial protein
RG49_RS23410	COG3539	Fimbrial protein
RG49_RS23425	COG2890	protein-(glutamine-N5) methyltransferase activity
RG49_RS23440	COG0730	response to heat
RG49_RS23445	COG3101	peptidyl-lysine hydroxylation
RG49_RS23460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG49_RS23470	COG2814	Major facilitator Superfamily
RG49_RS23485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG49_RS23495	COG0586	Pfam SNARE associated Golgi protein
RG49_RS23505	COG0285	dihydrofolate synthase activity
RG49_RS23510	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RG49_RS23515	COG1286	toxin biosynthetic process
RG49_RS23520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RG49_RS23525	COG0163	prenyltransferase activity
RG49_RS23530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS23535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG49_RS23540	COG4215	(ABC) transporter
RG49_RS23545	COG4160	amino acid transport
RG49_RS23550	COG4598	ABC transporter
RG49_RS23555	COG5464	transposase or invertase
RG49_RS23560	COG1090	epimerase
RG49_RS23565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG49_RS23570	COG0625	glutathione transferase activity
RG49_RS23575	COG0625	glutathione transferase activity
RG49_RS23580	COG0622	Phosphoesterase
RG49_RS23585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RG49_RS23590	COG1288	antiporter activity
RG49_RS23595	COG0857	belongs to the CobB CobQ family
RG49_RS23595	COG0280	phosphate acetyltransferase
RG49_RS23600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG49_RS23620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG49_RS23625	COG0490	domain, Protein
RG49_RS23625	COG0471	metal ion transport
RG49_RS23635	COG0436	Aminotransferase
RG49_RS23645	COG0583	DNA-binding transcription factor activity
RG49_RS23665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RG49_RS23670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RG49_RS23675	COG1034	ATP synthesis coupled electron transport
RG49_RS23690	COG0839	Belongs to the complex I subunit 6 family
RG49_RS23700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG49_RS23705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG49_RS23715	COG0457	Tetratricopeptide repeat
RG49_RS23735	COG2234	aminopeptidase activity
RG49_RS23740	COG2304	oxidoreductase activity
RG49_RS23745	COG5160	protein modification by small protein removal
RG49_RS23755	COG2153	protein acetylation
RG49_RS23760	COG4575	ribosome binding
RG49_RS23765	COG1169	isochorismate synthase
RG49_RS23780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RG49_RS23790	COG0318	PFAM AMP-dependent synthetase and ligase
RG49_RS23855	COG1414	Transcriptional regulator
RG49_RS23865	COG2271	Major facilitator Superfamily
RG49_RS23880	COG5464	transposase or invertase
RG49_RS23885	COG0247	lactate metabolic process
RG49_RS23895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG49_RS23900	COG2271	Major facilitator Superfamily
RG49_RS23905	COG0584	glycerophosphoryl diester phosphodiesterase
RG49_RS23910	COG0583	DNA-binding transcription factor activity
RG49_RS23920	COG3642	lipopolysaccharide core region biosynthetic process
RG49_RS23925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG49_RS23930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG49_RS23940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG49_RS23950	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS23960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG49_RS23965	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RG49_RS23970	COG3234	Protein of unknown function (DUF1175)
RG49_RS23975	COG2373	Large extracellular alpha-helical protein
RG49_RS23980	COG5445	Predicted secreted protein (DUF2300)
RG49_RS23985	COG4676	Protein conserved in bacteria
RG49_RS23990	COG0183	Belongs to the thiolase family
RG49_RS23995	COG2031	fatty acid transporter
RG49_RS24000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RG49_RS24005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RG49_RS24010	COG2204	response regulator
RG49_RS24015	COG3852	Histidine kinase
RG49_RS24020	COG0784	Response regulator, receiver
RG49_RS24020	COG2205	protein histidine kinase activity
RG49_RS24030	COG2197	response regulator
RG49_RS24035	COG2198	Histidine kinase
RG49_RS24035	COG0642	Histidine kinase
RG49_RS24050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG49_RS24055	COG1477	protein flavinylation
RG49_RS24060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG49_RS24060	COG2169	Transcriptional regulator
RG49_RS24065	COG3145	DNA-N1-methyladenine dioxygenase activity
RG49_RS24070	COG4615	Cyclic peptide transporter
RG49_RS24100	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS24100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG49_RS24105	COG3062	negative regulation of establishment of protein localization
RG49_RS24115	COG0437	4 iron, 4 sulfur cluster binding
RG49_RS24120	COG0348	domain, Protein
RG49_RS24125	COG3043	anaerobic respiration
RG49_RS24130	COG3005	denitrification pathway
RG49_RS24135	COG4133	protoheme IX ABC transporter activity
RG49_RS24140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG49_RS24145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG49_RS24150	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG49_RS24160	COG1138	Cytochrome C-type biogenesis protein
RG49_RS24165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RG49_RS24170	COG3088	subunit of a heme lyase
RG49_RS24170	COG4235	cytochrome complex assembly
RG49_RS24175	COG2197	response regulator
RG49_RS24185	COG3468	outer membrane autotransporter barrel domain protein
RG49_RS24200	COG3083	sulfuric ester hydrolase activity
RG49_RS24220	COG1061	Type III restriction enzyme res subunit
RG49_RS24230	COG1187	pseudouridine synthase activity
RG49_RS24235	COG2814	Major facilitator Superfamily
RG49_RS24250	COG4172	Belongs to the ABC transporter superfamily
RG49_RS24255	COG4239	(ABC) transporter, permease
RG49_RS24260	COG4174	ABC transporter (Permease)
RG49_RS24265	COG4166	transmembrane transport
RG49_RS24270	COG2200	EAL domain
RG49_RS24275	COG0791	NLP P60 protein
RG49_RS24280	COG0671	phosphoesterase, PA-phosphatase related
RG49_RS24285	COG0523	cobalamin synthesis protein
RG49_RS24290	COG0246	Mannitol dehydrogenase
RG49_RS24305	COG2814	Major facilitator Superfamily
RG49_RS24310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS24310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS24315	COG1105	Belongs to the carbohydrate kinase PfkB family
RG49_RS24320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS24320	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RG49_RS24320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG49_RS24325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS24330	COG2313	pseudouridylate synthase activity
RG49_RS24335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG49_RS24340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG49_RS24350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG49_RS24355	COG1522	sequence-specific DNA binding
RG49_RS24355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS24365	COG2855	membrane
RG49_RS24370	COG0583	DNA-binding transcription factor activity
RG49_RS24380	COG0833	amino acid
RG49_RS24385	COG4771	TonB-dependent receptor
RG49_RS24405	COG2311	Membrane
RG49_RS24415	COG1609	Transcriptional regulator
RG49_RS24420	COG1879	ABC-type sugar transport system periplasmic component
RG49_RS24425	COG1129	ABC transporter
RG49_RS24430	COG4211	Belongs to the binding-protein-dependent transport system permease family
RG49_RS24435	COG0167	dihydroorotate dehydrogenase activity
RG49_RS24435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RG49_RS24440	COG0493	'glutamate synthase
RG49_RS24450	COG2949	membrane
RG49_RS24460	COG1346	cytolysis
RG49_RS24470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG49_RS24495	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS24500	COG0586	Pfam SNARE associated Golgi protein
RG49_RS24510	COG1686	Belongs to the peptidase S11 family
RG49_RS24515	COG0277	FAD linked oxidase domain protein
RG49_RS24520	COG1472	Belongs to the glycosyl hydrolase 3 family
RG49_RS24525	COG1732	Glycine betaine
RG49_RS24530	COG1174	glycine betaine transport
RG49_RS24535	COG1125	glycine betaine transport
RG49_RS24540	COG1174	glycine betaine transport
RG49_RS24550	COG0789	Transcriptional regulator
RG49_RS24555	COG3275	phosphorelay sensor kinase activity
RG49_RS24560	COG3279	Response regulator of the LytR AlgR family
RG49_RS24565	COG4807	Protein conserved in bacteria
RG49_RS24570	COG4808	Protein conserved in bacteria
RG49_RS24575	COG4715	Zinc finger, swim domain protein
RG49_RS24580	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RG49_RS24585	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RG49_RS24590	COG0714	Associated with various cellular activities
RG49_RS24600	COG3831	ATPase activity
RG49_RS24615	COG0489	protein tyrosine kinase activity
RG49_RS24630	COG3539	Fimbrial protein
RG49_RS24635	COG3121	Chaperone
RG49_RS24640	COG3188	usher protein
RG49_RS24645	COG3539	Fimbrial protein
RG49_RS24650	COG5455	response to cobalt ion
RG49_RS24670	COG0351	phosphomethylpyrimidine kinase
RG49_RS24675	COG3757	hydrolase, family 25
RG49_RS24680	COG2188	Transcriptional regulator
RG49_RS24685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG49_RS24690	COG1397	ADP-ribosylglycohydrolase
RG49_RS24695	COG2211	Major facilitator Superfamily
RG49_RS24700	COG1830	Aldolase
RG49_RS24710	COG1069	ribulokinase activity
RG49_RS24735	COG1070	Carbohydrate kinase
RG49_RS24745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG49_RS24765	COG0826	peptidase U32
RG49_RS24780	COG0745	RESPONSE REGULATOR receiver
RG49_RS24785	COG2205	protein histidine kinase activity
RG49_RS24815	COG4245	von Willebrand factor, type A
RG49_RS24820	COG0631	protein serine/threonine phosphatase activity
RG49_RS24825	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
RG49_RS24830	COG0443	Heat shock 70 kDa protein
RG49_RS24840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RG49_RS24845	COG5001	Diguanylate cyclase
RG49_RS24845	COG3447	MASE1 domain protein
RG49_RS24845	COG5002	protein histidine kinase activity
RG49_RS24850	COG0572	uridine kinase
RG49_RS24860	COG2982	Protein involved in outer membrane biogenesis
RG49_RS24870	COG1253	flavin adenine dinucleotide binding
RG49_RS24875	COG1596	polysaccharide export
RG49_RS24880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG49_RS24885	COG0489	protein tyrosine kinase activity
RG49_RS24885	COG3206	protein involved in exopolysaccharide biosynthesis
RG49_RS24890	COG0463	Glycosyl transferase, family 2
RG49_RS24895	COG1045	serine acetyltransferase
RG49_RS24900	COG0438	transferase activity, transferring glycosyl groups
RG49_RS24910	COG1216	Glycosyl transferase, family 2
RG49_RS24915	COG0110	maltose O-acetyltransferase activity
RG49_RS24920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RG49_RS24925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG49_RS24930	COG1051	belongs to the nudix hydrolase family
RG49_RS24935	COG0297	glycogen (starch) synthase activity
RG49_RS24940	COG0662	Cupin 2, conserved barrel domain protein
RG49_RS24940	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RG49_RS24945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RG49_RS24950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RG49_RS24955	COG2244	polysaccharide biosynthetic process
RG49_RS24970	COG2327	Polysaccharide pyruvyl transferase
RG49_RS24975	COG0438	transferase activity, transferring glycosyl groups
RG49_RS24985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG49_RS24990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG49_RS25000	COG1088	dTDP-glucose 4,6-dehydratase activity
RG49_RS25005	COG1091	dTDP-4-dehydrorhamnose reductase activity
RG49_RS25010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG49_RS25055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RG49_RS25060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RG49_RS25070	COG0140	phosphoribosyl-ATP diphosphatase activity
RG49_RS25070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RG49_RS25085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RG49_RS25090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG49_RS25090	COG0131	Imidazoleglycerol-phosphate dehydratase
RG49_RS25100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RG49_RS25120	COG2161	toxin-antitoxin pair type II binding
RG49_RS25125	COG4115	mRNA cleavage
RG49_RS25130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG49_RS25135	COG0583	DNA-binding transcription factor activity
RG49_RS25140	COG0531	amino acid
RG49_RS25145	COG2391	methyltransferase activity
RG49_RS25150	COG0425	Belongs to the sulfur carrier protein TusA family
RG49_RS25155	COG2925	Exonuclease
RG49_RS25160	COG1686	Belongs to the peptidase S11 family
RG49_RS25170	COG1289	transmembrane transporter activity
RG49_RS25190	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RG49_RS25205	COG1376	ErfK ybiS ycfS ynhG family protein
RG49_RS25215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG49_RS25220	COG3414	Phosphotransferase system galactitol-specific IIB component
RG49_RS25225	COG3775	system Galactitol-specific IIC component
RG49_RS25230	COG0698	ribose 5-phosphate isomerase
RG49_RS25235	COG1349	DNA-binding transcription factor activity
RG49_RS25245	COG3414	Phosphotransferase system galactitol-specific IIB component
RG49_RS25250	COG3775	system Galactitol-specific IIC component
RG49_RS25255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG49_RS25260	COG1028	Short-chain dehydrogenase reductase Sdr
RG49_RS25265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG49_RS25290	COG3209	COG3209 Rhs family protein
RG49_RS25330	COG0583	DNA-binding transcription factor activity
RG49_RS25335	COG0583	DNA-binding transcription factor activity
RG49_RS25345	COG0534	Mate efflux family protein
RG49_RS25355	COG0217	transcriptional regulatory protein
RG49_RS25360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RG49_RS25365	COG0477	Major facilitator Superfamily
RG49_RS25380	COG1388	LysM domain
RG49_RS25380	COG1470	cell adhesion involved in biofilm formation
RG49_RS25390	COG3209	COG3209 Rhs family protein