locus-tag	class	description
HKW69_RS00010	COG0592	DNA-directed DNA polymerase activity
HKW69_RS00020	COG0187	DNA topoisomerase II activity
HKW69_RS00025	COG3753	Protein conserved in bacteria
HKW69_RS00030	COG0561	phosphatase activity
HKW69_RS00040	COG2186	Transcriptional regulator
HKW69_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HKW69_RS00050	COG0800	Aldolase
HKW69_RS00060	COG2271	Major facilitator Superfamily
HKW69_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
HKW69_RS00075	COG5645	(Lipo)protein
HKW69_RS00095	COG2207	Transcriptional regulator
HKW69_RS00100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKW69_RS00105	COG3119	arylsulfatase activity
HKW69_RS00110	COG2149	membrane
HKW69_RS00120	COG0641	radical SAM
HKW69_RS00125	COG2814	Major facilitator Superfamily
HKW69_RS00135	COG0028	Belongs to the TPP enzyme family
HKW69_RS00140	COG0440	acetolactate synthase activity
HKW69_RS00150	COG2197	response regulator
HKW69_RS00155	COG3851	Histidine kinase
HKW69_RS00160	COG2271	Major facilitator Superfamily
HKW69_RS00165	COG2271	Major facilitator Superfamily
HKW69_RS00175	COG2252	PERMEase
HKW69_RS00195	COG1464	Belongs to the NlpA lipoprotein family
HKW69_RS00200	COG0697	spore germination
HKW69_RS00255	COG2003	Belongs to the UPF0758 family
HKW69_RS00280	COG2378	regulation of single-species biofilm formation
HKW69_RS00285	COG3596	GTP binding
HKW69_RS00320	COG1349	DNA-binding transcription factor activity
HKW69_RS00330	COG0738	Major facilitator superfamily
HKW69_RS00340	COG2259	Doxx family
HKW69_RS00375	COG3436	PFAM IS66 Orf2 family protein
HKW69_RS00410	COG3708	Transcriptional regulator
HKW69_RS00410	COG2207	Transcriptional regulator
HKW69_RS00435	COG3436	PFAM IS66 Orf2 family protein
HKW69_RS00440	COG4372	Transposase
HKW69_RS00455	COG2801	Transposase and inactivated derivatives
HKW69_RS00480	COG4774	siderophore transport
HKW69_RS00480	COG1629	transport
HKW69_RS00485	COG3391	amine dehydrogenase activity
HKW69_RS00540	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HKW69_RS00550	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKW69_RS00560	COG0583	DNA-binding transcription factor activity
HKW69_RS00565	COG3619	membrane
HKW69_RS00600	COG3969	phosphoadenosine phosphosulfate
HKW69_RS00605	COG1475	DNA binding
HKW69_RS00620	COG1741	Belongs to the pirin family
HKW69_RS00625	COG3619	membrane
HKW69_RS00630	COG2207	Transcriptional regulator
HKW69_RS00635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HKW69_RS00650	COG3436	PFAM IS66 Orf2 family protein
HKW69_RS00660	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HKW69_RS00660	COG5295	Hep Hag repeat protein
HKW69_RS00710	COG0697	spore germination
HKW69_RS00725	COG3547	Transposase (IS116 IS110 IS902 family)
HKW69_RS00755	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HKW69_RS00765	COG4772	TonB-dependent receptor
HKW69_RS00770	COG1595	DNA-templated transcription, initiation
HKW69_RS00810	COG0582	viral genome integration into host DNA
HKW69_RS00820	COG2211	Major facilitator Superfamily
HKW69_RS00825	COG1501	Belongs to the glycosyl hydrolase 31 family
HKW69_RS00830	COG3711	transcriptional antiterminator
HKW69_RS00835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS00835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS00835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS00840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS00845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS00845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS00855	COG0191	fructose-bisphosphate aldolase activity
HKW69_RS00860	COG1940	carbohydrate kinase activity
HKW69_RS00870	COG2982	Protein involved in outer membrane biogenesis
HKW69_RS00875	COG2233	PERMEase
HKW69_RS00880	COG0786	glutamate:sodium symporter activity
HKW69_RS00885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKW69_RS00890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKW69_RS00895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKW69_RS00905	COG0194	GDP metabolic process
HKW69_RS00915	COG2860	membrane
HKW69_RS00920	COG3645	SOS response
HKW69_RS01165	COG1561	YicC-like family, N-terminal region
HKW69_RS01190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKW69_RS01220	COG1519	Transferase
HKW69_RS01225	COG0859	PFAM glycosyl transferase family 9
HKW69_RS01230	COG0438	transferase activity, transferring glycosyl groups
HKW69_RS01235	COG0515	serine threonine protein kinase
HKW69_RS01250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKW69_RS01255	COG1442	glycosyl transferase family 8
HKW69_RS01260	COG1216	Glycosyl transferase, family 2
HKW69_RS01265	COG3307	-O-antigen
HKW69_RS01270	COG0859	PFAM glycosyl transferase family 9
HKW69_RS01275	COG0859	PFAM glycosyl transferase family 9
HKW69_RS01285	COG0156	8-amino-7-oxononanoate synthase activity
HKW69_RS01295	COG1216	Glycosyl transferase, family 2
HKW69_RS01300	COG2861	carbohydrate metabolic process
HKW69_RS01305	COG4942	peptidase
HKW69_RS01315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKW69_RS01320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKW69_RS01335	COG1045	serine acetyltransferase
HKW69_RS01340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HKW69_RS01350	COG2186	Transcriptional regulator
HKW69_RS01355	COG1620	l-lactate permease
HKW69_RS01360	COG5295	Hep Hag repeat protein
HKW69_RS01380	COG3722	fumarate hydratase activity
HKW69_RS01390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS01390	COG2213	PTS system mannitol-specific
HKW69_RS01400	COG1566	PFAM secretion protein HlyD family protein
HKW69_RS01405	COG0625	glutathione transferase activity
HKW69_RS01415	COG3276	selenocysteine insertion sequence binding
HKW69_RS01420	COG1454	alcohol dehydrogenase
HKW69_RS01425	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS01430	COG0235	Class ii aldolase
HKW69_RS01435	COG3623	hexulose-6-phosphate isomerase
HKW69_RS01440	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HKW69_RS01445	COG1070	Carbohydrate kinase
HKW69_RS01450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HKW69_RS01455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HKW69_RS01460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HKW69_RS01470	COG2731	YhcH YjgK YiaL family protein
HKW69_RS01480	COG1414	Transcriptional regulator
HKW69_RS01485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS01490	COG3977	Valine--pyruvate aminotransferase
HKW69_RS01495	COG0366	Alpha amylase catalytic
HKW69_RS01500	COG2992	FlgJ-related protein
HKW69_RS01505	COG2207	Transcriptional regulator
HKW69_RS01505	COG1609	Transcriptional regulator
HKW69_RS01510	COG4214	carbohydrate transport
HKW69_RS01520	COG4213	ABC transporter substrate-binding protein
HKW69_RS01530	COG1070	Carbohydrate kinase
HKW69_RS01535	COG4682	membrane
HKW69_RS01540	COG4682	membrane
HKW69_RS01545	COG3274	enterobacterial common antigen metabolic process
HKW69_RS01570	COG1278	Cold shock
HKW69_RS01575	COG2944	sequence-specific DNA binding
HKW69_RS01590	COG2885	chlorophyll binding
HKW69_RS01595	COG0243	molybdopterin cofactor binding
HKW69_RS01600	COG0456	acetyltransferase
HKW69_RS01605	COG2818	Glycosylase
HKW69_RS01610	COG5571	outer membrane autotransporter
HKW69_RS01615	COG2223	nitrite transmembrane transporter activity
HKW69_RS01620	COG2194	sulfuric ester hydrolase activity
HKW69_RS01630	COG0747	negative chemotaxis
HKW69_RS01635	COG0601	transmembrane transport
HKW69_RS01640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKW69_RS01645	COG0444	Belongs to the ABC transporter superfamily
HKW69_RS01650	COG4608	Belongs to the ABC transporter superfamily
HKW69_RS01655	COG0814	amino acid
HKW69_RS01690	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS01695	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS01700	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HKW69_RS01705	COG0457	Tetratricopeptide repeat
HKW69_RS01705	COG3118	belongs to the thioredoxin family
HKW69_RS01710	COG2199	diguanylate cyclase activity
HKW69_RS01710	COG2200	EAL domain
HKW69_RS01720	COG0612	Peptidase, M16
HKW69_RS01725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS01730	COG2200	EAL domain
HKW69_RS01735	COG2982	Protein involved in outer membrane biogenesis
HKW69_RS01740	COG0477	Major facilitator Superfamily
HKW69_RS01745	COG1295	ribonuclease BN
HKW69_RS01750	COG0583	DNA-binding transcription factor activity
HKW69_RS01755	COG2197	response regulator
HKW69_RS01765	COG1858	cytochrome C peroxidase
HKW69_RS01770	COG0076	glutamate decarboxylase activity
HKW69_RS01785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKW69_RS01790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS01800	COG2771	luxR family
HKW69_RS01805	COG3247	response to pH
HKW69_RS01820	COG1285	pathogenesis
HKW69_RS01830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS01840	COG3721	Heme iron utilization protein
HKW69_RS01855	COG4771	TonB-dependent receptor
HKW69_RS01860	COG3720	iron ion transport
HKW69_RS01865	COG2197	response regulator
HKW69_RS01870	COG3065	identical protein binding
HKW69_RS01880	COG1393	Belongs to the ArsC family
HKW69_RS01890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKW69_RS01895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HKW69_RS01900	COG0339	signal peptide processing
HKW69_RS01915	COG0589	response to stress
HKW69_RS01925	COG0306	phosphate transporter
HKW69_RS01930	COG2081	HI0933 family
HKW69_RS01940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS01945	COG0842	Transport permease protein
HKW69_RS01945	COG1129	ABC transporter
HKW69_RS01950	COG0842	Transport permease protein
HKW69_RS01970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKW69_RS01975	COG0601	transmembrane transport
HKW69_RS01980	COG0747	negative chemotaxis
HKW69_RS01985	COG2091	lysine biosynthetic process via aminoadipic acid
HKW69_RS01990	COG0628	permease
HKW69_RS01995	COG0477	Major facilitator Superfamily
HKW69_RS02005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HKW69_RS02020	COG3714	YhhN family
HKW69_RS02030	COG3776	membrane
HKW69_RS02035	COG0742	ribosomal rna small subunit methyltransferase
HKW69_RS02040	COG0552	protein localization to endoplasmic reticulum
HKW69_RS02045	COG2884	Cell division ATP-binding protein ftsE
HKW69_RS02050	COG2177	Part of the ABC transporter FtsEX involved in
HKW69_RS02055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKW69_RS02060	COG0683	leucine binding
HKW69_RS02065	COG0456	acetyltransferase
HKW69_RS02070	COG0683	leucine binding
HKW69_RS02075	COG0559	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS02080	COG4177	L-phenylalanine transmembrane transporter activity
HKW69_RS02085	COG0411	ABC transporter
HKW69_RS02090	COG0410	ABC transporter
HKW69_RS02115	COG0584	glycerophosphoryl diester phosphodiesterase
HKW69_RS02125	COG0405	Gamma-glutamyltransferase
HKW69_RS02145	COG3157	Type VI secretion system effector, Hcp
HKW69_RS02155	COG1247	-acetyltransferase
HKW69_RS02160	COG0673	inositol 2-dehydrogenase activity
HKW69_RS02165	COG1741	Belongs to the pirin family
HKW69_RS02170	COG1609	Transcriptional regulator
HKW69_RS02175	COG3265	gluconokinase activity
HKW69_RS02180	COG2610	gluconate transmembrane transporter activity
HKW69_RS02185	COG0514	ATP-dependent DNA helicase (RecQ)
HKW69_RS02195	COG2095	MarC family integral membrane protein
HKW69_RS02200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKW69_RS02225	COG0058	SHG alpha-glucan phosphorylase activity
HKW69_RS02235	COG3121	Chaperone
HKW69_RS02240	COG3188	usher protein
HKW69_RS02280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKW69_RS02295	COG1349	DNA-binding transcription factor activity
HKW69_RS02300	COG4650	regulator
HKW69_RS02305	COG1690	Belongs to the RtcB family
HKW69_RS02320	COG0058	SHG alpha-glucan phosphorylase activity
HKW69_RS02325	COG1640	4-alpha-glucanotransferase
HKW69_RS02330	COG2610	gluconate transmembrane transporter activity
HKW69_RS02350	COG5464	transposase or invertase
HKW69_RS02360	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HKW69_RS02365	COG1918	ferrous iron import across plasma membrane
HKW69_RS02370	COG2183	response to ionizing radiation
HKW69_RS02375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKW69_RS02380	COG0745	RESPONSE REGULATOR receiver
HKW69_RS02385	COG2205	protein histidine kinase activity
HKW69_RS02405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKW69_RS02410	COG1011	Hydrolase
HKW69_RS02420	COG0494	nUDIX hydrolase
HKW69_RS02425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HKW69_RS02430	COG4972	Pilus assembly protein
HKW69_RS02435	COG3166	PFAM Fimbrial assembly family protein
HKW69_RS02450	COG4796	Type ii and iii secretion system protein
HKW69_RS02465	COG3266	domain, Protein
HKW69_RS02470	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HKW69_RS02475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKW69_RS02485	COG0180	Tryptophanyl-tRNA synthetase
HKW69_RS02490	COG2188	Transcriptional regulator
HKW69_RS02500	COG3457	Alanine racemase
HKW69_RS02505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HKW69_RS02510	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HKW69_RS02525	COG0626	cystathionine gamma-synthase activity
HKW69_RS02540	COG2116	formate transmembrane transporter activity
HKW69_RS02545	COG2146	nitrite reductase [NAD(P)H] activity
HKW69_RS02550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKW69_RS02560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKW69_RS02570	COG2184	nucleotidyltransferase activity
HKW69_RS02575	COG0512	Glutamine amidotransferase of anthranilate synthase
HKW69_RS02580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKW69_RS02585	COG1289	transmembrane transporter activity
HKW69_RS02590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKW69_RS02595	COG1765	OsmC-like protein
HKW69_RS02600	COG3954	Phosphoribulokinase
HKW69_RS02615	COG0488	(ABC) transporter
HKW69_RS02630	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HKW69_RS02635	COG1047	Peptidyl-prolyl cis-trans
HKW69_RS02645	COG0545	Peptidyl-prolyl cis-trans isomerase
HKW69_RS02650	COG2964	Protein conserved in bacteria
HKW69_RS02690	COG3979	chitinase
HKW69_RS02695	COG2906	2 iron, 2 sulfur cluster binding
HKW69_RS02700	COG2193	ferroxidase activity
HKW69_RS02705	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HKW69_RS02710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HKW69_RS02715	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HKW69_RS02720	COG3156	type II secretion system protein K
HKW69_RS02725	COG4795	General secretion pathway protein
HKW69_RS02730	COG2165	general secretion pathway protein
HKW69_RS02735	COG2165	general secretion pathway protein
HKW69_RS02740	COG2165	general secretion pathway protein
HKW69_RS02745	COG1459	type II secretion system
HKW69_RS02750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKW69_RS02755	COG1450	Type ii and iii secretion system protein
HKW69_RS02760	COG3031	protein transport across the cell outer membrane
HKW69_RS02765	COG3267	Type II secretory pathway component ExeA
HKW69_RS02765	COG3409	Peptidoglycan-binding domain 1 protein
HKW69_RS02790	COG0089	rRNA binding
HKW69_RS02880	COG0201	protein transport
HKW69_RS02920	COG0789	Transcriptional regulator
HKW69_RS02925	COG3036	rescue of stalled ribosome
HKW69_RS02935	COG0569	domain protein
HKW69_RS02955	COG0758	DNA mediated transformation
HKW69_RS02965	COG0551	DNA topoisomerase type I activity
HKW69_RS02985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKW69_RS03025	COG1126	abc transporter atp-binding protein
HKW69_RS03030	COG0765	amino acid transport
HKW69_RS03035	COG4597	amino acid ABC transporter
HKW69_RS03040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS03055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS03060	COG1309	transcriptional regulator
HKW69_RS03070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HKW69_RS03080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKW69_RS03090	COG4145	pantothenate transmembrane transporter activity
HKW69_RS03095	COG3924	membrane
HKW69_RS03100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS03105	COG1349	DNA-binding transcription factor activity
HKW69_RS03125	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS03130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS03140	COG0439	Biotin carboxylase
HKW69_RS03145	COG0511	ligase activity, forming carbon-carbon bonds
HKW69_RS03155	COG0604	alcohol dehydrogenase
HKW69_RS03160	COG2199	diguanylate cyclase activity
HKW69_RS03160	COG2200	EAL domain
HKW69_RS03165	COG1077	Cell shape determining protein MreB Mrl
HKW69_RS03170	COG1792	Involved in formation and maintenance of cell shape
HKW69_RS03175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HKW69_RS03185	COG1530	ribonuclease E activity
HKW69_RS03190	COG3164	Protein of unknown function
HKW69_RS03195	COG0312	modulator of DNA gyrase
HKW69_RS03200	COG0583	DNA-binding transcription factor activity
HKW69_RS03220	COG2732	(Barnase) inhibitor
HKW69_RS03240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKW69_RS03245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKW69_RS03250	COG3105	Protein conserved in bacteria
HKW69_RS03255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKW69_RS03270	COG0625	glutathione transferase activity
HKW69_RS03275	COG2969	positive regulation of protein catabolic process
HKW69_RS03305	COG2731	YhcH YjgK YiaL family protein
HKW69_RS03310	COG4804	nuclease activity
HKW69_RS03315	COG0493	'glutamate synthase
HKW69_RS03320	COG0069	glutamate synthase activity
HKW69_RS03320	COG0067	glutamate synthase
HKW69_RS03320	COG0070	glutamate synthase
HKW69_RS03325	COG1242	4 iron, 4 sulfur cluster binding
HKW69_RS03330	COG2198	Histidine kinase
HKW69_RS03330	COG5002	protein histidine kinase activity
HKW69_RS03330	COG0784	Response regulator, receiver
HKW69_RS03335	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HKW69_RS03345	COG0515	serine threonine protein kinase
HKW69_RS03350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS03365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKW69_RS03370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HKW69_RS03375	COG1137	ATPase activity
HKW69_RS03380	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HKW69_RS03385	COG3117	lipopolysaccharide transmembrane transporter activity
HKW69_RS03390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HKW69_RS03395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HKW69_RS03395	COG0517	IMP dehydrogenase activity
HKW69_RS03400	COG0530	calcium, potassium:sodium antiporter activity
HKW69_RS03405	COG1127	ABC transporter
HKW69_RS03410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKW69_RS03415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKW69_RS03420	COG2854	intermembrane phospholipid transfer
HKW69_RS03425	COG3113	response to antibiotic
HKW69_RS03430	COG5007	Belongs to the BolA IbaG family
HKW69_RS03440	COG3423	Transcriptional regulator
HKW69_RS03445	COG0142	geranyltranstransferase activity
HKW69_RS03460	COG0697	spore germination
HKW69_RS03470	COG2027	D-alanyl-D-alanine carboxypeptidase
HKW69_RS03475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKW69_RS03480	COG1534	Rna-binding protein
HKW69_RS03490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKW69_RS03495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKW69_RS03505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKW69_RS03535	COG0195	Participates in both transcription termination and antitermination
HKW69_RS03575	COG0513	Belongs to the DEAD box helicase family
HKW69_RS03580	COG0814	amino acid
HKW69_RS03585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKW69_RS03590	COG0826	peptidase U32
HKW69_RS03595	COG0826	peptidase U32
HKW69_RS03600	COG3154	lipid carrier protein
HKW69_RS03605	COG3153	acetyltransferase
HKW69_RS03620	COG0693	protein deglycase activity
HKW69_RS03625	COG0702	epimerase
HKW69_RS03635	COG2823	Periplasmic or secreted lipoprotein
HKW69_RS03650	COG3107	peptidoglycan biosynthetic process
HKW69_RS03655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HKW69_RS03660	COG0363	glucosamine-6-phosphate deaminase activity
HKW69_RS03665	COG3716	PTS system mannose fructose sorbose family IID component
HKW69_RS03670	COG3715	PTS system
HKW69_RS03675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS03685	COG2222	sugar isomerase
HKW69_RS03690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKW69_RS03695	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS03700	COG3716	PTS system mannose fructose sorbose family IID component
HKW69_RS03710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS03720	COG1349	DNA-binding transcription factor activity
HKW69_RS03730	COG2002	toxin-antitoxin pair type II binding
HKW69_RS03735	COG2721	sulfolactate sulfo-lyase activity
HKW69_RS03740	COG2271	Major facilitator Superfamily
HKW69_RS03750	COG2084	Dehydrogenase
HKW69_RS03755	COG1929	Belongs to the glycerate kinase type-1 family
HKW69_RS03770	COG0583	DNA-binding transcription factor activity
HKW69_RS03775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKW69_RS03785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKW69_RS03790	COG1882	Formate acetyltransferase
HKW69_RS03795	COG0251	oxidation-reduction process
HKW69_RS03800	COG1760	l-serine dehydratase
HKW69_RS03805	COG0814	amino acid
HKW69_RS03820	COG1741	Belongs to the pirin family
HKW69_RS03825	COG0583	DNA-binding transcription factor activity
HKW69_RS03830	COG3152	Membrane
HKW69_RS03835	COG0435	Glutathione S-transferase
HKW69_RS03840	COG2259	Doxx family
HKW69_RS03850	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HKW69_RS03855	COG4575	ribosome binding
HKW69_RS03860	COG1422	Protein of unknown function (DUF1090)
HKW69_RS03870	COG0586	Pfam SNARE associated Golgi protein
HKW69_RS03875	COG2186	Transcriptional regulator
HKW69_RS03900	COG2271	Major facilitator Superfamily
HKW69_RS03910	COG2721	sulfolactate sulfo-lyase activity
HKW69_RS03925	COG0861	Integral membrane protein TerC family
HKW69_RS03930	COG0673	inositol 2-dehydrogenase activity
HKW69_RS03935	COG2949	membrane
HKW69_RS03940	COG1451	nucleotide metabolic process
HKW69_RS03955	COG5499	transcription regulator containing HTH domain
HKW69_RS03960	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKW69_RS03960	COG1902	pentaerythritol trinitrate reductase activity
HKW69_RS03965	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HKW69_RS03965	COG3408	Glycogen debranching enzyme
HKW69_RS03980	COG0531	amino acid
HKW69_RS03985	COG2731	YhcH YjgK YiaL family protein
HKW69_RS03990	COG3250	beta-galactosidase activity
HKW69_RS03995	COG1609	Transcriptional regulator
HKW69_RS04000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKW69_RS04010	COG0840	transmembrane signaling receptor activity
HKW69_RS04015	COG1695	Transcriptional regulator
HKW69_RS04020	COG2375	cellular response to nickel ion
HKW69_RS04035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKW69_RS04040	COG0358	DNA primase activity
HKW69_RS04045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HKW69_RS04055	COG0471	metal ion transport
HKW69_RS04060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HKW69_RS04080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKW69_RS04095	COG4991	sh3 domain protein
HKW69_RS04100	COG3025	triphosphatase activity
HKW69_RS04105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKW69_RS04120	COG2268	Band 7 protein
HKW69_RS04125	COG1585	Membrane protein implicated in regulation of membrane protease activity
HKW69_RS04155	COG3384	dioxygenase
HKW69_RS04165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HKW69_RS04175	COG0754	glutathionylspermidine amidase activity
HKW69_RS04185	COG1538	Outer membrane efflux protein
HKW69_RS04200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKW69_RS04205	COG3150	esterase
HKW69_RS04210	COG0187	DNA topoisomerase II activity
HKW69_RS04235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS04255	COG2211	Major facilitator Superfamily
HKW69_RS04260	COG4774	siderophore transport
HKW69_RS04265	COG1120	ATPase activity
HKW69_RS04270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS04275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS04285	COG1737	Transcriptional regulator
HKW69_RS04290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HKW69_RS04295	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKW69_RS04310	COG0642	Histidine kinase
HKW69_RS04315	COG0745	RESPONSE REGULATOR receiver
HKW69_RS04320	COG3111	PFAM Bacterial OB fold (BOF) protein
HKW69_RS04325	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HKW69_RS04330	COG4166	transmembrane transport
HKW69_RS04335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKW69_RS04340	COG0204	Acyl-transferase
HKW69_RS04345	COG2132	Multicopper oxidase
HKW69_RS04365	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HKW69_RS04370	COG1063	alcohol dehydrogenase
HKW69_RS04380	COG2186	Transcriptional regulator
HKW69_RS04385	COG1032	radical SAM domain protein
HKW69_RS04390	COG4238	major outer membrane lipoprotein
HKW69_RS04400	COG0656	L-ascorbic acid biosynthetic process
HKW69_RS04405	COG1979	alcohol dehydrogenase
HKW69_RS04410	COG2207	Transcriptional regulator
HKW69_RS04415	COG0586	Pfam SNARE associated Golgi protein
HKW69_RS04420	COG0626	cystathionine gamma-synthase activity
HKW69_RS04425	COG0811	peptide transport
HKW69_RS04430	COG0848	biopolymer transport protein
HKW69_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS04445	COG0667	Aldo Keto reductase
HKW69_RS04460	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HKW69_RS04465	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS04470	COG5557	Pfam Polysulphide reductase, NrfD
HKW69_RS04475	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HKW69_RS04480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HKW69_RS04485	COG1773	rubredoxin
HKW69_RS04490	COG0375	protein maturation
HKW69_RS04495	COG0298	carbon dioxide binding
HKW69_RS04500	COG0625	glutathione transferase activity
HKW69_RS04505	COG0754	glutathionylspermidine amidase activity
HKW69_RS04510	COG0306	phosphate transporter
HKW69_RS04515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKW69_RS04520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKW69_RS04525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKW69_RS04530	COG2244	polysaccharide biosynthetic process
HKW69_RS04540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HKW69_RS04545	COG0795	lipopolysaccharide-transporting ATPase activity
HKW69_RS04555	COG0156	8-amino-7-oxononanoate synthase activity
HKW69_RS04560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKW69_RS04575	COG0456	acetyltransferase
HKW69_RS04580	COG2186	Transcriptional regulator
HKW69_RS04585	COG0277	FAD linked oxidase domain protein
HKW69_RS04590	COG0277	FAD linked oxidase domain protein
HKW69_RS04595	COG0247	lactate metabolic process
HKW69_RS04600	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HKW69_RS04605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HKW69_RS04610	COG1620	l-lactate permease
HKW69_RS04615	COG3064	Membrane
HKW69_RS04620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HKW69_RS04640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKW69_RS04645	COG1459	type II secretion system
HKW69_RS04650	COG2165	general secretion pathway protein
HKW69_RS04665	COG4795	General secretion pathway protein
HKW69_RS04680	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HKW69_RS04705	COG1216	Glycosyl transferase, family 2
HKW69_RS04710	COG0562	UDP-galactopyranose mutase
HKW69_RS04715	COG0110	maltose O-acetyltransferase activity
HKW69_RS04725	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS04795	COG2003	Belongs to the UPF0758 family
HKW69_RS04820	COG2020	methyltransferase activity
HKW69_RS04825	COG3468	outer membrane autotransporter barrel domain protein
HKW69_RS04835	COG4983	Phage plasmid primase, P4 family domain protein
HKW69_RS04880	COG1349	DNA-binding transcription factor activity
HKW69_RS04890	COG0738	Major facilitator superfamily
HKW69_RS04905	COG3037	sugar-specific permease SgaT UlaA
HKW69_RS04915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS04925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKW69_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS04940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKW69_RS04965	COG1216	Glycosyl transferase, family 2
HKW69_RS04970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKW69_RS04985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKW69_RS04995	COG0204	Acyl-transferase
HKW69_RS05225	COG2194	sulfuric ester hydrolase activity
HKW69_RS05235	COG0582	viral genome integration into host DNA
HKW69_RS05245	COG3609	addiction module antidote protein, CC2985 family
HKW69_RS05280	COG2003	Belongs to the UPF0758 family
HKW69_RS05305	COG3596	GTP binding
HKW69_RS05395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKW69_RS05425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HKW69_RS05460	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HKW69_RS05475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKW69_RS05520	COG2194	sulfuric ester hydrolase activity
HKW69_RS05530	COG0582	viral genome integration into host DNA
HKW69_RS05540	COG1811	Na channel or pump
HKW69_RS05545	COG1982	Orn Lys Arg decarboxylase major
HKW69_RS05550	COG2211	Major facilitator Superfamily
HKW69_RS05565	COG1194	a g-specific adenine glycosylase
HKW69_RS05575	COG3171	Protein conserved in bacteria
HKW69_RS05585	COG0252	asparaginase activity
HKW69_RS05595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKW69_RS05600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKW69_RS05610	COG0762	integral membrane protein
HKW69_RS05615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HKW69_RS05620	COG2805	Type II/IV secretion system protein
HKW69_RS05635	COG0189	ligase activity
HKW69_RS05640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKW69_RS05645	COG2356	endonuclease I
HKW69_RS05655	COG2814	Major facilitator Superfamily
HKW69_RS05675	COG1166	arginine decarboxylase activity
HKW69_RS05690	COG0501	Belongs to the peptidase M48B family
HKW69_RS05695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKW69_RS05700	COG0330	HflC and HflK could
HKW69_RS05705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS05710	COG2213	PTS system mannitol-specific
HKW69_RS05715	COG1063	alcohol dehydrogenase
HKW69_RS05730	COG1072	(Pantothenic acid kinase))
HKW69_RS05735	COG1122	ATPase activity
HKW69_RS05770	COG0191	fructose-bisphosphate aldolase activity
HKW69_RS05775	COG0668	transmembrane transport
HKW69_RS05780	COG1279	arginine transmembrane transporter activity
HKW69_RS05785	COG2968	Membrane
HKW69_RS05790	COG0583	DNA-binding transcription factor activity
HKW69_RS05795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKW69_RS05795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HKW69_RS05815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKW69_RS05825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKW69_RS05845	COG0006	proline dipeptidase activity
HKW69_RS05850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKW69_RS05855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKW69_RS05880	COG2723	6-phospho-beta-galactosidase activity
HKW69_RS05890	COG1272	protein, Hemolysin III
HKW69_RS05900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HKW69_RS05910	COG0716	FMN binding
HKW69_RS05915	COG4974	Belongs to the 'phage' integrase family
HKW69_RS05920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKW69_RS05925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HKW69_RS05935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKW69_RS05955	COG2233	PERMEase
HKW69_RS05965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS05970	COG2252	PERMEase
HKW69_RS05975	COG0402	S-adenosylhomocysteine deaminase activity
HKW69_RS05980	COG2233	PERMEase
HKW69_RS05985	COG2080	2 iron, 2 sulfur cluster binding
HKW69_RS05985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKW69_RS05990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HKW69_RS05995	COG0402	S-adenosylhomocysteine deaminase activity
HKW69_RS06000	COG0493	'glutamate synthase
HKW69_RS06000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS06005	COG2068	MobA-Related Protein
HKW69_RS06010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKW69_RS06015	COG3608	succinylglutamate desuccinylase aspartoacylase
HKW69_RS06015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKW69_RS06020	COG0549	Belongs to the carbamate kinase family
HKW69_RS06030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKW69_RS06035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKW69_RS06050	COG2080	2 iron, 2 sulfur cluster binding
HKW69_RS06055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HKW69_RS06060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKW69_RS06065	COG4942	peptidase
HKW69_RS06075	COG0814	amino acid
HKW69_RS06080	COG0183	Belongs to the thiolase family
HKW69_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS06095	COG2814	Major facilitator Superfamily
HKW69_RS06100	COG1794	racemase activity, acting on amino acids and derivatives
HKW69_RS06105	COG0583	DNA-binding transcription factor activity
HKW69_RS06115	COG1609	Transcriptional regulator
HKW69_RS06130	COG0667	Aldo Keto reductase
HKW69_RS06140	COG0861	Integral membrane protein TerC family
HKW69_RS06155	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HKW69_RS06170	COG2165	general secretion pathway protein
HKW69_RS06175	COG4795	General secretion pathway protein
HKW69_RS06185	COG4967	type IV pilus modification protein PilV
HKW69_RS06190	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HKW69_RS06195	COG1025	Belongs to the peptidase M16 family
HKW69_RS06200	COG1074	ATP-dependent DNA helicase activity
HKW69_RS06205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKW69_RS06210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKW69_RS06210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HKW69_RS06215	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKW69_RS06220	COG3711	transcriptional antiterminator
HKW69_RS06225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS06225	COG1263	PTS System
HKW69_RS06230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKW69_RS06330	COG2885	chlorophyll binding
HKW69_RS06370	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HKW69_RS06375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HKW69_RS06380	COG2166	iron-sulfur cluster assembly
HKW69_RS06385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKW69_RS06395	COG0583	DNA-binding transcription factor activity
HKW69_RS06400	COG2363	Small membrane protein
HKW69_RS06410	COG1349	DNA-binding transcription factor activity
HKW69_RS06420	COG1070	Carbohydrate kinase
HKW69_RS06430	COG0738	Major facilitator superfamily
HKW69_RS06440	COG1454	alcohol dehydrogenase
HKW69_RS06450	COG1760	l-serine dehydratase
HKW69_RS06455	COG0814	amino acid
HKW69_RS06460	COG1611	Belongs to the LOG family
HKW69_RS06475	COG3098	single-species biofilm formation
HKW69_RS06480	COG0564	pseudouridine synthase activity
HKW69_RS06485	COG0716	FMN binding
HKW69_RS06490	COG2271	Major facilitator Superfamily
HKW69_RS06495	COG4948	Mandelate Racemase Muconate Lactonizing
HKW69_RS06500	COG4948	Mandelate Racemase Muconate Lactonizing
HKW69_RS06505	COG2205	protein histidine kinase activity
HKW69_RS06505	COG3850	Histidine kinase
HKW69_RS06505	COG4999	Histidine kinase
HKW69_RS06505	COG3437	response regulator, receiver
HKW69_RS06515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKW69_RS06520	COG2336	PFAM SpoVT AbrB
HKW69_RS06525	COG2337	Toxic component of a toxin-antitoxin (TA) module
HKW69_RS06530	COG3956	TIGRFAM MazG family protein
HKW69_RS06545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HKW69_RS06555	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HKW69_RS06565	COG0602	queuosine metabolic process
HKW69_RS06595	COG1070	Carbohydrate kinase
HKW69_RS06600	COG2223	nitrite transmembrane transporter activity
HKW69_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS06610	COG0277	FAD linked oxidase domain protein
HKW69_RS06615	COG0477	Major facilitator Superfamily
HKW69_RS06620	COG2086	electron transfer activity
HKW69_RS06625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HKW69_RS06630	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HKW69_RS06635	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HKW69_RS06640	COG0644	oxidoreductase
HKW69_RS06645	COG0720	synthase
HKW69_RS06670	COG2234	aminopeptidase activity
HKW69_RS06725	COG1388	LysM domain
HKW69_RS06725	COG4942	peptidase
HKW69_RS06730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKW69_RS06745	COG2610	gluconate transmembrane transporter activity
HKW69_RS06750	COG3622	Belongs to the hyi family
HKW69_RS06755	COG0235	Class ii aldolase
HKW69_RS06760	COG3395	kinase activity
HKW69_RS06765	COG2084	Dehydrogenase
HKW69_RS06770	COG1349	DNA-binding transcription factor activity
HKW69_RS06815	COG3335	DDE superfamily endonuclease
HKW69_RS06845	COG3604	Transcriptional regulator
HKW69_RS06850	COG0309	Hydrogenase expression formation protein (HypE)
HKW69_RS06855	COG0409	Hydrogenase expression formation protein
HKW69_RS06860	COG0298	carbon dioxide binding
HKW69_RS06865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKW69_RS06870	COG0375	protein maturation
HKW69_RS06880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS06885	COG0651	ATP synthesis coupled electron transport
HKW69_RS06890	COG0650	Formate hydrogenlyase subunit 4
HKW69_RS06895	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HKW69_RS06895	COG3261	NADH dehydrogenase
HKW69_RS06900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKW69_RS06905	COG3260	NADH ubiquinone oxidoreductase 20
HKW69_RS06915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HKW69_RS06925	COG5499	transcription regulator containing HTH domain
HKW69_RS06930	COG2723	6-phospho-beta-galactosidase activity
HKW69_RS06935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS06935	COG1263	PTS System
HKW69_RS06940	COG1609	Transcriptional regulator
HKW69_RS06945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS06950	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HKW69_RS06970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HKW69_RS06970	COG0517	IMP dehydrogenase activity
HKW69_RS06975	COG1349	DNA-binding transcription factor activity
HKW69_RS06980	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS06995	COG3732	PTS system glucitol sorbitol-specific
HKW69_RS07000	COG3730	PTS system glucitol sorbitol-specific
HKW69_RS07005	COG2951	lytic endotransglycosylase activity
HKW69_RS07010	COG1546	Belongs to the CinA family
HKW69_RS07030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKW69_RS07060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKW69_RS07065	COG1238	metal cluster binding
HKW69_RS07080	COG2814	Major facilitator Superfamily
HKW69_RS07085	COG1566	PFAM secretion protein HlyD family protein
HKW69_RS07090	COG1846	Transcriptional regulator
HKW69_RS07105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKW69_RS07110	COG2814	Major facilitator Superfamily
HKW69_RS07115	COG2113	Glycine betaine
HKW69_RS07120	COG4176	ABC-type proline glycine betaine transport system permease component
HKW69_RS07125	COG4175	Glycine betaine
HKW69_RS07130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKW69_RS07135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKW69_RS07145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKW69_RS07150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKW69_RS07160	COG4575	ribosome binding
HKW69_RS07175	COG2916	Histone family protein nucleoid-structuring protein H-NS
HKW69_RS07180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKW69_RS07185	COG0640	Transcriptional regulator
HKW69_RS07190	COG0401	homolog of Blt101
HKW69_RS07195	COG1652	LysM domain
HKW69_RS07200	COG1802	Transcriptional regulator
HKW69_RS07205	COG1113	amino acid transport
HKW69_RS07210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKW69_RS07215	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS07220	COG0579	oxidoreductase
HKW69_RS07240	COG2867	negative regulation of translational initiation
HKW69_RS07250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKW69_RS07255	COG0497	DNA recombination
HKW69_RS07270	COG4536	flavin adenine dinucleotide binding
HKW69_RS07275	COG4137	Cytochrome C assembly protein
HKW69_RS07280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKW69_RS07305	COG2885	chlorophyll binding
HKW69_RS07310	COG2199	diguanylate cyclase activity
HKW69_RS07325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKW69_RS07330	COG0287	Prephenate dehydrogenase
HKW69_RS07330	COG1605	Chorismate mutase
HKW69_RS07335	COG0077	Prephenate dehydratase
HKW69_RS07335	COG1605	Chorismate mutase
HKW69_RS07345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKW69_RS07350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKW69_RS07355	COG0564	pseudouridine synthase activity
HKW69_RS07365	COG0542	response to heat
HKW69_RS07400	COG0477	Major facilitator Superfamily
HKW69_RS07405	COG5544	Lipoprotein
HKW69_RS07410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKW69_RS07415	COG1042	CoA-binding domain protein
HKW69_RS07415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKW69_RS07415	COG0045	succinate-CoA ligase (ADP-forming) activity
HKW69_RS07425	COG3118	belongs to the thioredoxin family
HKW69_RS07430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKW69_RS07450	COG0583	DNA-binding transcription factor activity
HKW69_RS07455	COG0513	Belongs to the DEAD box helicase family
HKW69_RS07465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HKW69_RS07475	COG1595	DNA-templated transcription, initiation
HKW69_RS07480	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HKW69_RS07485	COG3026	antisigma factor binding
HKW69_RS07490	COG3086	response to oxidative stress
HKW69_RS07500	COG0681	Belongs to the peptidase S26 family
HKW69_RS07520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HKW69_RS07540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS07545	COG1737	Transcriptional regulator
HKW69_RS07550	COG0560	Phosphoserine phosphatase
HKW69_RS07555	COG0590	tRNA wobble adenosine to inosine editing
HKW69_RS07570	COG2205	protein histidine kinase activity
HKW69_RS07575	COG3170	Tfp pilus assembly protein FimV
HKW69_RS07580	COG2204	response regulator
HKW69_RS07585	COG0347	Belongs to the P(II) protein family
HKW69_RS07590	COG1017	nitric oxide dioxygenase activity
HKW69_RS07590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKW69_RS07600	COG1940	carbohydrate kinase activity
HKW69_RS07610	COG1879	ABC-type sugar transport system periplasmic component
HKW69_RS07615	COG1129	ABC transporter
HKW69_RS07620	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS07625	COG1063	alcohol dehydrogenase
HKW69_RS07630	COG2017	converts alpha-aldose to the beta-anomer
HKW69_RS07640	COG2259	Doxx family
HKW69_RS07645	COG2814	Major facilitator Superfamily
HKW69_RS07650	COG3711	transcriptional antiterminator
HKW69_RS07655	COG1073	alpha beta
HKW69_RS07660	COG0483	inositol monophosphate 1-phosphatase activity
HKW69_RS07680	COG0822	iron-sulfur transferase activity
HKW69_RS07700	COG0633	Ferredoxin
HKW69_RS07705	COG2975	iron-sulfur cluster assembly
HKW69_RS07720	COG2897	thiosulfate sulfurtransferase activity
HKW69_RS07725	COG2373	Large extracellular alpha-helical protein
HKW69_RS07730	COG4953	penicillin-binding protein 1C
HKW69_RS07760	COG2976	Protein conserved in bacteria
HKW69_RS07775	COG1645	bacterial-type flagellum-dependent swarming motility
HKW69_RS07800	COG0517	IMP dehydrogenase activity
HKW69_RS07800	COG0516	GMP reductase activity
HKW69_RS07840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKW69_RS07910	COG3728	DNA packaging
HKW69_RS07910	COG5484	DNA packaging
HKW69_RS08010	COG3561	AntA/AntB antirepressor
HKW69_RS08045	COG3179	chitinase
HKW69_RS08060	COG3133	Outer membrane lipoprotein
HKW69_RS08075	COG2200	EAL domain
HKW69_RS08080	COG0248	Ppx GppA phosphatase
HKW69_RS08085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HKW69_RS08090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKW69_RS08105	COG2233	PERMEase
HKW69_RS08115	COG1393	Belongs to the ArsC family
HKW69_RS08120	COG4783	chaperone-mediated protein folding
HKW69_RS08125	COG0628	permease
HKW69_RS08130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKW69_RS08135	COG2716	regulation of RNA biosynthetic process
HKW69_RS08145	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HKW69_RS08155	COG2321	neutral zinc metallopeptidase
HKW69_RS08165	COG0400	carboxylic ester hydrolase activity
HKW69_RS08180	COG1393	Belongs to the ArsC family
HKW69_RS08190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKW69_RS08195	COG3850	Histidine kinase
HKW69_RS08200	COG0493	'glutamate synthase
HKW69_RS08200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS08210	COG5342	invasion associated locus B
HKW69_RS08215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKW69_RS08220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKW69_RS08225	COG0280	phosphate acetyltransferase
HKW69_RS08225	COG0281	malic enzyme
HKW69_RS08230	COG4810	utilization protein
HKW69_RS08235	COG4917	ethanolamine utilization protein
HKW69_RS08240	COG4766	ethanolamine catabolic process
HKW69_RS08245	COG4812	Cobalamin adenosyltransferase
HKW69_RS08250	COG0280	phosphate acetyltransferase
HKW69_RS08255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HKW69_RS08260	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HKW69_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS08270	COG4820	ethanolamine utilization protein (EutJ)
HKW69_RS08275	COG1454	alcohol dehydrogenase
HKW69_RS08280	COG3192	ethanolamine utilization protein
HKW69_RS08285	COG4819	ethanolamine utilization protein
HKW69_RS08290	COG4303	Ethanolamine ammonia lyase large subunit
HKW69_RS08300	COG4816	utilization protein
HKW69_RS08305	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HKW69_RS08310	COG2207	Transcriptional regulator
HKW69_RS08320	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKW69_RS08340	COG2837	iron assimilation
HKW69_RS08345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS08345	COG1263	PTS System
HKW69_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS08360	COG4150	thiosulfate binding
HKW69_RS08365	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HKW69_RS08370	COG4208	sulfate ABC transporter
HKW69_RS08375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HKW69_RS08380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKW69_RS08395	COG2190	(PTS) system
HKW69_RS08400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKW69_RS08405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS08410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKW69_RS08430	COG3530	Putative quorum-sensing-regulated virulence factor
HKW69_RS08435	COG0385	Bile acid
HKW69_RS08440	COG0583	DNA-binding transcription factor activity
HKW69_RS08450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HKW69_RS08455	COG2211	Major facilitator Superfamily
HKW69_RS08465	COG0583	DNA-binding transcription factor activity
HKW69_RS08495	COG3415	Transposase
HKW69_RS08500	COG3415	Transposase
HKW69_RS08515	COG2199	diguanylate cyclase activity
HKW69_RS08515	COG2200	EAL domain
HKW69_RS08520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HKW69_RS08545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS08550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS08555	COG0006	proline dipeptidase activity
HKW69_RS08560	COG1363	Peptidase, m42
HKW69_RS08565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS08565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS08565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKW69_RS08570	COG2207	Transcriptional regulator
HKW69_RS08575	COG3279	Response regulator of the LytR AlgR family
HKW69_RS08580	COG3275	phosphorelay sensor kinase activity
HKW69_RS08585	COG0436	Aminotransferase
HKW69_RS08595	COG1560	Kdo2-lipid A biosynthetic process
HKW69_RS08620	COG0028	Belongs to the TPP enzyme family
HKW69_RS08625	COG0679	Auxin Efflux Carrier
HKW69_RS08630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKW69_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS08635	COG2198	Histidine kinase
HKW69_RS08635	COG2205	protein histidine kinase activity
HKW69_RS08635	COG0784	Response regulator, receiver
HKW69_RS08640	COG2197	response regulator
HKW69_RS08645	COG1566	PFAM secretion protein HlyD family protein
HKW69_RS08650	COG0477	Major facilitator Superfamily
HKW69_RS08695	COG2116	formate transmembrane transporter activity
HKW69_RS08705	COG2067	long-chain fatty acid transport protein
HKW69_RS08710	COG3691	Protein conserved in bacteria
HKW69_RS08725	COG2062	phosphohistidine phosphatase, SixA
HKW69_RS08730	COG3539	Fimbrial protein
HKW69_RS08735	COG3188	usher protein
HKW69_RS08740	COG3121	Chaperone
HKW69_RS08745	COG3539	Fimbrial protein
HKW69_RS08750	COG3539	Fimbrial protein
HKW69_RS08755	COG3539	Fimbrial protein
HKW69_RS08785	COG0730	response to heat
HKW69_RS08790	COG3101	peptidyl-lysine hydroxylation
HKW69_RS08805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKW69_RS08810	COG2814	Major facilitator Superfamily
HKW69_RS08825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKW69_RS08855	COG0586	Pfam SNARE associated Golgi protein
HKW69_RS08865	COG0285	dihydrofolate synthase activity
HKW69_RS08870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HKW69_RS08875	COG1286	toxin biosynthetic process
HKW69_RS08880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HKW69_RS08885	COG0163	prenyltransferase activity
HKW69_RS08890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS08895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS08900	COG4215	(ABC) transporter
HKW69_RS08905	COG4160	amino acid transport
HKW69_RS08910	COG4598	ABC transporter
HKW69_RS08915	COG5464	transposase or invertase
HKW69_RS08920	COG1090	epimerase
HKW69_RS08925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKW69_RS08930	COG0625	glutathione transferase activity
HKW69_RS08935	COG0625	glutathione transferase activity
HKW69_RS08940	COG0622	Phosphoesterase
HKW69_RS08945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HKW69_RS08950	COG1288	antiporter activity
HKW69_RS08955	COG0857	belongs to the CobB CobQ family
HKW69_RS08955	COG0280	phosphate acetyltransferase
HKW69_RS08960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKW69_RS08975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKW69_RS08980	COG0490	domain, Protein
HKW69_RS08980	COG0471	metal ion transport
HKW69_RS08990	COG0436	Aminotransferase
HKW69_RS08995	COG0583	DNA-binding transcription factor activity
HKW69_RS09015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HKW69_RS09020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKW69_RS09025	COG1034	ATP synthesis coupled electron transport
HKW69_RS09040	COG0839	Belongs to the complex I subunit 6 family
HKW69_RS09050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKW69_RS09055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKW69_RS09070	COG2234	aminopeptidase activity
HKW69_RS09075	COG5160	protein modification by small protein removal
HKW69_RS09085	COG2153	protein acetylation
HKW69_RS09090	COG4575	ribosome binding
HKW69_RS09095	COG1169	isochorismate synthase
HKW69_RS09110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HKW69_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
HKW69_RS09185	COG1414	Transcriptional regulator
HKW69_RS09195	COG2271	Major facilitator Superfamily
HKW69_RS09210	COG5464	transposase or invertase
HKW69_RS09215	COG0247	lactate metabolic process
HKW69_RS09225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKW69_RS09230	COG2271	Major facilitator Superfamily
HKW69_RS09235	COG0584	glycerophosphoryl diester phosphodiesterase
HKW69_RS09240	COG3642	lipopolysaccharide core region biosynthetic process
HKW69_RS09245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKW69_RS09250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKW69_RS09255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKW69_RS09260	COG3468	outer membrane autotransporter barrel domain protein
HKW69_RS09270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKW69_RS09275	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HKW69_RS09280	COG3234	Protein of unknown function (DUF1175)
HKW69_RS09290	COG5445	Predicted secreted protein (DUF2300)
HKW69_RS09295	COG4676	Protein conserved in bacteria
HKW69_RS09300	COG0183	Belongs to the thiolase family
HKW69_RS09305	COG2031	fatty acid transporter
HKW69_RS09310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKW69_RS09315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKW69_RS09320	COG2204	response regulator
HKW69_RS09325	COG3852	Histidine kinase
HKW69_RS09330	COG2205	protein histidine kinase activity
HKW69_RS09330	COG0784	Response regulator, receiver
HKW69_RS09335	COG2197	response regulator
HKW69_RS09340	COG0642	Histidine kinase
HKW69_RS09340	COG2198	Histidine kinase
HKW69_RS09345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HKW69_RS09350	COG1477	protein flavinylation
HKW69_RS09355	COG2169	Transcriptional regulator
HKW69_RS09355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKW69_RS09360	COG3145	DNA-N1-methyladenine dioxygenase activity
HKW69_RS09365	COG4615	Cyclic peptide transporter
HKW69_RS09380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS09380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKW69_RS09385	COG3062	negative regulation of establishment of protein localization
HKW69_RS09395	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS09400	COG0348	domain, Protein
HKW69_RS09405	COG3043	anaerobic respiration
HKW69_RS09410	COG3005	denitrification pathway
HKW69_RS09415	COG4133	protoheme IX ABC transporter activity
HKW69_RS09420	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HKW69_RS09425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HKW69_RS09430	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HKW69_RS09440	COG1138	Cytochrome C-type biogenesis protein
HKW69_RS09445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKW69_RS09450	COG4235	cytochrome complex assembly
HKW69_RS09450	COG3088	subunit of a heme lyase
HKW69_RS09455	COG2197	response regulator
HKW69_RS09470	COG3083	sulfuric ester hydrolase activity
HKW69_RS09490	COG1061	Type III restriction enzyme res subunit
HKW69_RS09495	COG1187	pseudouridine synthase activity
HKW69_RS09500	COG2814	Major facilitator Superfamily
HKW69_RS09510	COG4172	Belongs to the ABC transporter superfamily
HKW69_RS09515	COG4239	(ABC) transporter, permease
HKW69_RS09520	COG4174	ABC transporter (Permease)
HKW69_RS09525	COG4166	transmembrane transport
HKW69_RS09530	COG2200	EAL domain
HKW69_RS09535	COG0791	NLP P60 protein
HKW69_RS09540	COG0671	phosphoesterase, PA-phosphatase related
HKW69_RS09545	COG0523	cobalamin synthesis protein
HKW69_RS09550	COG0246	Mannitol dehydrogenase
HKW69_RS09565	COG2814	Major facilitator Superfamily
HKW69_RS09570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS09570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS09575	COG1105	Belongs to the carbohydrate kinase PfkB family
HKW69_RS09580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS09580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS09580	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HKW69_RS09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS09590	COG2313	pseudouridylate synthase activity
HKW69_RS09595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HKW69_RS09600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKW69_RS09615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS09615	COG1522	sequence-specific DNA binding
HKW69_RS09625	COG2855	membrane
HKW69_RS09630	COG0583	DNA-binding transcription factor activity
HKW69_RS09635	COG0833	amino acid
HKW69_RS09640	COG4771	TonB-dependent receptor
HKW69_RS09655	COG2311	Membrane
HKW69_RS09660	COG1609	Transcriptional regulator
HKW69_RS09665	COG1879	ABC-type sugar transport system periplasmic component
HKW69_RS09675	COG4211	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS09680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HKW69_RS09680	COG0167	dihydroorotate dehydrogenase activity
HKW69_RS09685	COG0493	'glutamate synthase
HKW69_RS09695	COG2949	membrane
HKW69_RS09705	COG1346	cytolysis
HKW69_RS09715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKW69_RS09725	COG1538	Outer membrane efflux protein
HKW69_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS09735	COG0586	Pfam SNARE associated Golgi protein
HKW69_RS09745	COG1686	Belongs to the peptidase S11 family
HKW69_RS09750	COG0277	FAD linked oxidase domain protein
HKW69_RS09755	COG1472	Belongs to the glycosyl hydrolase 3 family
HKW69_RS09760	COG1732	Glycine betaine
HKW69_RS09770	COG1125	glycine betaine transport
HKW69_RS09775	COG1174	glycine betaine transport
HKW69_RS09785	COG0789	Transcriptional regulator
HKW69_RS09790	COG3275	phosphorelay sensor kinase activity
HKW69_RS09795	COG3279	Response regulator of the LytR AlgR family
HKW69_RS09800	COG4807	Protein conserved in bacteria
HKW69_RS09805	COG4808	Protein conserved in bacteria
HKW69_RS09815	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HKW69_RS09820	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HKW69_RS09825	COG0714	Associated with various cellular activities
HKW69_RS09835	COG3831	ATPase activity
HKW69_RS09840	COG3831	ATPase activity
HKW69_RS09850	COG0489	protein tyrosine kinase activity
HKW69_RS09860	COG3539	Fimbrial protein
HKW69_RS09865	COG3121	Chaperone
HKW69_RS09870	COG3188	usher protein
HKW69_RS09875	COG3539	Fimbrial protein
HKW69_RS09880	COG5455	response to cobalt ion
HKW69_RS09900	COG0351	phosphomethylpyrimidine kinase
HKW69_RS09905	COG3757	hydrolase, family 25
HKW69_RS09910	COG2188	Transcriptional regulator
HKW69_RS09915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS09920	COG1397	ADP-ribosylglycohydrolase
HKW69_RS09925	COG2211	Major facilitator Superfamily
HKW69_RS09930	COG1830	Aldolase
HKW69_RS09945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS09950	COG3414	Phosphotransferase system galactitol-specific IIB component
HKW69_RS09955	COG3775	system Galactitol-specific IIC component
HKW69_RS09960	COG1063	alcohol dehydrogenase
HKW69_RS10010	COG0745	RESPONSE REGULATOR receiver
HKW69_RS10015	COG2205	protein histidine kinase activity
HKW69_RS10050	COG4245	von Willebrand factor, type A
HKW69_RS10055	COG0631	protein serine/threonine phosphatase activity
HKW69_RS10060	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HKW69_RS10065	COG0443	Heat shock 70 kDa protein
HKW69_RS10070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HKW69_RS10075	COG3447	MASE1 domain protein
HKW69_RS10075	COG5002	protein histidine kinase activity
HKW69_RS10075	COG5001	Diguanylate cyclase
HKW69_RS10080	COG0572	uridine kinase
HKW69_RS10090	COG2982	Protein involved in outer membrane biogenesis
HKW69_RS10095	COG1253	flavin adenine dinucleotide binding
HKW69_RS10100	COG1596	polysaccharide export
HKW69_RS10105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKW69_RS10110	COG0489	protein tyrosine kinase activity
HKW69_RS10110	COG3206	protein involved in exopolysaccharide biosynthesis
HKW69_RS10115	COG0463	Glycosyl transferase, family 2
HKW69_RS10120	COG1045	serine acetyltransferase
HKW69_RS10125	COG0438	transferase activity, transferring glycosyl groups
HKW69_RS10135	COG1216	Glycosyl transferase, family 2
HKW69_RS10140	COG0110	maltose O-acetyltransferase activity
HKW69_RS10145	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HKW69_RS10150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKW69_RS10155	COG1051	belongs to the nudix hydrolase family
HKW69_RS10160	COG0297	glycogen (starch) synthase activity
HKW69_RS10165	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HKW69_RS10165	COG0662	Cupin 2, conserved barrel domain protein
HKW69_RS10170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKW69_RS10175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKW69_RS10180	COG2244	polysaccharide biosynthetic process
HKW69_RS10185	COG2327	Polysaccharide pyruvyl transferase
HKW69_RS10190	COG0438	transferase activity, transferring glycosyl groups
HKW69_RS10200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKW69_RS10215	COG1216	Glycosyl transferase, family 2
HKW69_RS10230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKW69_RS10245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKW69_RS10250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HKW69_RS10255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HKW69_RS10260	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HKW69_RS10265	COG0140	phosphoribosyl-ATP diphosphatase activity
HKW69_RS10265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKW69_RS10280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKW69_RS10285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HKW69_RS10285	COG0131	Imidazoleglycerol-phosphate dehydratase
HKW69_RS10295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKW69_RS10310	COG2161	toxin-antitoxin pair type II binding
HKW69_RS10315	COG4115	mRNA cleavage
HKW69_RS10320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKW69_RS10325	COG0583	DNA-binding transcription factor activity
HKW69_RS10335	COG0531	amino acid
HKW69_RS10340	COG2925	Exonuclease
HKW69_RS10345	COG1686	Belongs to the peptidase S11 family
HKW69_RS10355	COG1289	transmembrane transporter activity
HKW69_RS10370	COG4372	Transposase
HKW69_RS10400	COG2003	Belongs to the UPF0758 family
HKW69_RS10455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS10460	COG1120	ATPase activity
HKW69_RS10510	COG3547	Transposase (IS116 IS110 IS902 family)
HKW69_RS10545	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HKW69_RS10560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS10580	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS10585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKW69_RS10595	COG3969	phosphoadenosine phosphosulfate
HKW69_RS10600	COG1475	DNA binding
HKW69_RS10605	COG4771	TonB-dependent receptor
HKW69_RS10610	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HKW69_RS10625	COG1376	ErfK ybiS ycfS ynhG family protein
HKW69_RS10650	COG2197	response regulator
HKW69_RS10665	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKW69_RS10670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKW69_RS10675	COG1960	acyl-CoA dehydrogenase activity
HKW69_RS10705	COG0154	amidase activity
HKW69_RS10730	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HKW69_RS10740	COG0582	viral genome integration into host DNA
HKW69_RS10750	COG0534	Mate efflux family protein
HKW69_RS10760	COG0583	DNA-binding transcription factor activity
HKW69_RS10765	COG0583	DNA-binding transcription factor activity
HKW69_RS10775	COG0217	transcriptional regulatory protein
HKW69_RS10780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKW69_RS10785	COG0477	Major facilitator Superfamily
HKW69_RS10805	COG1470	cell adhesion involved in biofilm formation
HKW69_RS10805	COG1388	LysM domain
HKW69_RS10810	COG1388	LysM domain
HKW69_RS10810	COG1470	cell adhesion involved in biofilm formation
HKW69_RS10815	COG1388	LysM domain
HKW69_RS10815	COG2373	Large extracellular alpha-helical protein
HKW69_RS10815	COG4932	domain protein
HKW69_RS10820	COG4771	TonB-dependent receptor
HKW69_RS10825	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKW69_RS10845	COG2226	methyltransferase
HKW69_RS10845	COG3433	isochorismatase activity
HKW69_RS10845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKW69_RS10860	COG1132	(ABC) transporter
HKW69_RS10865	COG2814	Major facilitator Superfamily
HKW69_RS10875	COG0582	viral genome integration into host DNA
HKW69_RS11015	COG0582	viral genome integration into host DNA
HKW69_RS11020	COG3443	Belongs to the bacterial solute-binding protein 9 family
HKW69_RS11035	COG2351	hydroxyisourate hydrolase activity
HKW69_RS11040	COG0745	RESPONSE REGULATOR receiver
HKW69_RS11045	COG2205	protein histidine kinase activity
HKW69_RS11055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HKW69_RS11065	COG1418	mRNA catabolic process
HKW69_RS11070	COG0270	DNA (cytosine-5-)-methyltransferase activity
HKW69_RS11075	COG3727	T/G mismatch-specific endonuclease activity
HKW69_RS11080	COG0697	spore germination
HKW69_RS11085	COG2354	Protein conserved in bacteria
HKW69_RS11090	COG5475	Uncharacterized small protein (DUF2158)
HKW69_RS11120	COG1684	flagellar biosynthetic protein fliR
HKW69_RS11125	COG1987	bacterial-type flagellum assembly
HKW69_RS11130	COG1338	Plays a role in the flagellum-specific transport system
HKW69_RS11135	COG3190	flagellar
HKW69_RS11140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HKW69_RS11145	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HKW69_RS11150	COG1580	Controls the rotational direction of flagella during chemotaxis
HKW69_RS11155	COG3144	bacterial-type flagellum assembly
HKW69_RS11160	COG2882	bacterial-type flagellum organization
HKW69_RS11165	COG1157	protein secretion by the type III secretion system
HKW69_RS11170	COG1317	bacterial-type flagellum organization
HKW69_RS11175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HKW69_RS11180	COG1766	The M ring may be actively involved in energy transduction
HKW69_RS11190	COG2076	Multidrug Resistance protein
HKW69_RS11195	COG1881	PFAM PEBP family protein
HKW69_RS11200	COG2207	Transcriptional regulator
HKW69_RS11210	COG2135	peptidase activity
HKW69_RS11215	COG0425	Belongs to the sulfur carrier protein TusA family
HKW69_RS11220	COG2391	methyltransferase activity
HKW69_RS11230	COG0366	Alpha amylase catalytic
HKW69_RS11240	COG1516	flagellar protein fliS
HKW69_RS11245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HKW69_RS11255	COG1191	sigma factor activity
HKW69_RS11285	COG2197	response regulator
HKW69_RS11300	COG2197	response regulator
HKW69_RS11330	COG3318	Belongs to the UPF0149 family
HKW69_RS11330	COG3012	SEC-C Motif Domain Protein
HKW69_RS11335	COG0814	amino acid
HKW69_RS11345	COG1528	Iron-storage protein
HKW69_RS11365	COG1528	Iron-storage protein
HKW69_RS11370	COG1879	ABC-type sugar transport system periplasmic component
HKW69_RS11380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS11385	COG1877	trehalose-phosphatase activity
HKW69_RS11395	COG0589	response to stress
HKW69_RS11410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HKW69_RS11415	COG1360	Flagellar Motor Protein
HKW69_RS11420	COG2198	Histidine kinase
HKW69_RS11420	COG0643	Histidine kinase
HKW69_RS11425	COG0835	chemotaxis
HKW69_RS11430	COG0840	transmembrane signaling receptor activity
HKW69_RS11440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKW69_RS11450	COG0745	RESPONSE REGULATOR receiver
HKW69_RS11455	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HKW69_RS11460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKW69_RS11465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKW69_RS11480	COG3102	Protein conserved in bacteria
HKW69_RS11490	COG3005	denitrification pathway
HKW69_RS11495	COG0243	molybdopterin cofactor binding
HKW69_RS11510	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HKW69_RS11515	COG1801	Protein of unknown function DUF72
HKW69_RS11520	COG1335	isochorismatase
HKW69_RS11530	COG0494	nUDIX hydrolase
HKW69_RS11535	COG0217	transcriptional regulatory protein
HKW69_RS11565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKW69_RS11575	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HKW69_RS11580	COG0739	heme binding
HKW69_RS11585	COG1560	Kdo2-lipid A biosynthetic process
HKW69_RS11590	COG0469	pyruvate kinase activity
HKW69_RS11595	COG1737	Transcriptional regulator
HKW69_RS11600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKW69_RS11605	COG0129	dihydroxy-acid dehydratase activity
HKW69_RS11610	COG0800	Aldolase
HKW69_RS11620	COG3141	response to X-ray
HKW69_RS11630	COG2979	Protein of unknown function (DUF533)
HKW69_RS11635	COG1770	oligopeptidase
HKW69_RS11640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKW69_RS11645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKW69_RS11655	COG2372	response to copper ion
HKW69_RS11660	COG1276	copper resistance
HKW69_RS11670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKW69_RS11690	COG3008	intermembrane lipid transfer
HKW69_RS11695	COG2995	paraquat-inducible protein a
HKW69_RS11700	COG1956	GAF domain-containing protein
HKW69_RS11710	COG0793	Belongs to the peptidase S41A family
HKW69_RS11725	COG1414	Transcriptional regulator
HKW69_RS11755	COG2226	methyltransferase
HKW69_RS11770	COG3716	PTS system mannose fructose sorbose family IID component
HKW69_RS11775	COG3715	PTS system
HKW69_RS11780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS11780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS11785	COG1253	flavin adenine dinucleotide binding
HKW69_RS11790	COG2200	EAL domain
HKW69_RS11795	COG1760	l-serine dehydratase
HKW69_RS11805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKW69_RS11820	COG0251	oxidation-reduction process
HKW69_RS11825	COG1199	ATP-dependent helicase activity
HKW69_RS11830	COG1214	PFAM Peptidase M22, glycoprotease
HKW69_RS11835	COG3065	identical protein binding
HKW69_RS11840	COG0318	PFAM AMP-dependent synthetase and ligase
HKW69_RS11845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HKW69_RS11850	COG0583	DNA-binding transcription factor activity
HKW69_RS11860	COG3615	Tellurite resistance protein tehB
HKW69_RS11870	COG2261	transglycosylase associated protein
HKW69_RS11885	COG2199	diguanylate cyclase activity
HKW69_RS11885	COG2203	Gaf domain
HKW69_RS11890	COG3042	response to heat
HKW69_RS11895	COG3189	MarR family transcriptional regulator
HKW69_RS11900	COG2807	transmembrane transport
HKW69_RS11905	COG2207	Transcriptional regulator
HKW69_RS11920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKW69_RS11925	COG2199	diguanylate cyclase activity
HKW69_RS11930	COG2199	diguanylate cyclase activity
HKW69_RS11940	COG2766	serine protein kinase
HKW69_RS11945	COG3713	MltA-interacting MipA family protein
HKW69_RS11950	COG0656	L-ascorbic acid biosynthetic process
HKW69_RS11955	COG0676	glucose-6-phosphate 1-epimerase activity
HKW69_RS11960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HKW69_RS11970	COG3139	Protein of unknown function (DUF1315)
HKW69_RS11975	COG1063	alcohol dehydrogenase
HKW69_RS11980	COG2271	Major facilitator Superfamily
HKW69_RS11985	COG1063	alcohol dehydrogenase
HKW69_RS11990	COG0191	fructose-bisphosphate aldolase activity
HKW69_RS11995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS12000	COG0667	Aldo Keto reductase
HKW69_RS12005	COG1349	DNA-binding transcription factor activity
HKW69_RS12025	COG1335	isochorismatase
HKW69_RS12030	COG0252	asparaginase activity
HKW69_RS12035	COG0616	signal peptide processing
HKW69_RS12040	COG0778	Nitroreductase
HKW69_RS12045	COG0709	Synthesizes selenophosphate from selenide and ATP
HKW69_RS12050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKW69_RS12055	COG0443	Heat shock 70 kDa protein
HKW69_RS12070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKW69_RS12080	COG0494	nUDIX hydrolase
HKW69_RS12085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKW69_RS12090	COG2897	thiosulfate sulfurtransferase activity
HKW69_RS12095	COG4136	ATPase activity
HKW69_RS12100	COG4135	transport system, permease component
HKW69_RS12105	COG4134	Bacterial extracellular solute-binding protein
HKW69_RS12110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKW69_RS12115	COG0398	Pfam SNARE associated Golgi protein
HKW69_RS12125	COG0398	Pfam SNARE associated Golgi protein
HKW69_RS12130	COG0708	Exodeoxyribonuclease III
HKW69_RS12160	COG3678	ATP-independent chaperone mediated protein folding
HKW69_RS12170	COG0322	excinuclease ABC activity
HKW69_RS12180	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKW69_RS12185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKW69_RS12190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKW69_RS12195	COG1447	Phosphotransferase system cellobiose-specific component IIA
HKW69_RS12200	COG1917	Cupin 2, conserved barrel domain protein
HKW69_RS12200	COG2169	Transcriptional regulator
HKW69_RS12205	COG1486	melibiose metabolic process
HKW69_RS12215	COG0753	catalase activity
HKW69_RS12230	COG1988	membrane-bound metal-dependent
HKW69_RS12235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKW69_RS12245	COG3001	Fructosamine kinase
HKW69_RS12255	COG1105	Belongs to the carbohydrate kinase PfkB family
HKW69_RS12260	COG3137	Salt-induced outer membrane protein
HKW69_RS12320	COG0386	Belongs to the glutathione peroxidase family
HKW69_RS12330	COG0791	NLP P60 protein
HKW69_RS12335	COG2200	EAL domain
HKW69_RS12345	COG4256	Hemin uptake protein
HKW69_RS12350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKW69_RS12360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKW69_RS12360	COG0574	Belongs to the PEP-utilizing enzyme family
HKW69_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
HKW69_RS12370	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HKW69_RS12375	COG0644	oxidoreductase
HKW69_RS12380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HKW69_RS12385	COG2086	electron transfer activity
HKW69_RS12390	COG2207	Transcriptional regulator
HKW69_RS12390	COG1917	Cupin 2, conserved barrel domain protein
HKW69_RS12395	COG1960	acyl-CoA dehydrogenase activity
HKW69_RS12400	COG4670	ketone body catabolic process
HKW69_RS12415	COG2271	Major facilitator Superfamily
HKW69_RS12420	COG0738	Major facilitator superfamily
HKW69_RS12435	COG0628	permease
HKW69_RS12440	COG0277	FAD linked oxidase domain protein
HKW69_RS12440	COG0247	lactate metabolic process
HKW69_RS12445	COG2050	protein possibly involved in aromatic compounds catabolism
HKW69_RS12455	COG0316	Belongs to the HesB IscA family
HKW69_RS12460	COG0719	Fe-S assembly protein
HKW69_RS12465	COG0396	ATPase activity
HKW69_RS12470	COG0719	Fe-S assembly protein
HKW69_RS12485	COG1376	ErfK ybiS ycfS ynhG family protein
HKW69_RS12490	COG4238	major outer membrane lipoprotein
HKW69_RS12495	COG0469	pyruvate kinase activity
HKW69_RS12505	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS12510	COG2414	aldehyde ferredoxin oxidoreductase
HKW69_RS12520	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS12525	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HKW69_RS12535	COG4529	Protein conserved in bacteria
HKW69_RS12555	COG3468	outer membrane autotransporter barrel domain protein
HKW69_RS12565	COG0307	riboflavin synthase, alpha
HKW69_RS12570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HKW69_RS12575	COG2814	Major facilitator Superfamily
HKW69_RS12580	COG0583	DNA-binding transcription factor activity
HKW69_RS12595	COG2814	Major facilitator Superfamily
HKW69_RS12600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKW69_RS12605	COG0791	NLP P60 protein
HKW69_RS12610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKW69_RS12620	COG0346	lactoylglutathione lyase activity
HKW69_RS12625	COG1902	pentaerythritol trinitrate reductase activity
HKW69_RS12630	COG1309	transcriptional regulator
HKW69_RS12635	COG3313	Fe-S protein
HKW69_RS12640	COG4989	oxidoreductase activity
HKW69_RS12645	COG2032	superoxide dismutase activity
HKW69_RS12650	COG1289	transmembrane transporter activity
HKW69_RS12655	COG1566	PFAM secretion protein HlyD family protein
HKW69_RS12670	COG3133	Outer membrane lipoprotein
HKW69_RS12680	COG3895	Periplasmic Protein
HKW69_RS12700	COG0625	glutathione transferase activity
HKW69_RS12705	COG3104	oligopeptide transport
HKW69_RS12710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKW69_RS12720	COG4659	FMN binding
HKW69_RS12760	COG0673	inositol 2-dehydrogenase activity
HKW69_RS12770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKW69_RS12775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS12775	COG1263	PTS System
HKW69_RS12780	COG1609	Transcriptional regulator
HKW69_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS12790	COG1309	transcriptional regulator
HKW69_RS12795	COG3250	beta-galactosidase activity
HKW69_RS12810	COG5339	Protein conserved in bacteria
HKW69_RS12815	COG1482	cell wall glycoprotein biosynthetic process
HKW69_RS12820	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HKW69_RS12820	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HKW69_RS12825	COG0114	fumarate hydratase activity
HKW69_RS12840	COG0745	RESPONSE REGULATOR receiver
HKW69_RS12845	COG3136	membrane protein required for alginate biosynthesis
HKW69_RS12855	COG0531	amino acid
HKW69_RS12865	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HKW69_RS12870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HKW69_RS12875	COG0628	permease
HKW69_RS12890	COG3591	Belongs to the peptidase S1B family
HKW69_RS12905	COG2814	Major facilitator Superfamily
HKW69_RS12910	COG0583	DNA-binding transcription factor activity
HKW69_RS12915	COG1940	carbohydrate kinase activity
HKW69_RS12920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HKW69_RS12930	COG3381	protein complex oligomerization
HKW69_RS12950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKW69_RS12965	COG4948	Mandelate Racemase Muconate Lactonizing
HKW69_RS12970	COG1063	alcohol dehydrogenase
HKW69_RS12975	COG0477	Major facilitator Superfamily
HKW69_RS12980	COG0246	Mannitol dehydrogenase
HKW69_RS12990	COG1802	Transcriptional regulator
HKW69_RS12995	COG4221	oxidoreductase activity
HKW69_RS13000	COG0339	signal peptide processing
HKW69_RS13010	COG3706	GGDEF domain
HKW69_RS13020	COG2814	Major facilitator Superfamily
HKW69_RS13025	COG0697	spore germination
HKW69_RS13040	COG2723	6-phospho-beta-galactosidase activity
HKW69_RS13050	COG4977	sequence-specific DNA binding
HKW69_RS13055	COG1846	Transcriptional regulator
HKW69_RS13075	COG0583	DNA-binding transcription factor activity
HKW69_RS13080	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS13085	COG2066	Belongs to the glutaminase family
HKW69_RS13095	COG2199	diguanylate cyclase activity
HKW69_RS13105	COG3781	membrane
HKW69_RS13115	COG1396	sequence-specific DNA binding
HKW69_RS13120	COG3550	peptidyl-serine autophosphorylation
HKW69_RS13200	COG3539	Fimbrial protein
HKW69_RS13210	COG3188	usher protein
HKW69_RS13215	COG3539	Fimbrial protein
HKW69_RS13220	COG3539	Fimbrial protein
HKW69_RS13225	COG3539	Fimbrial protein
HKW69_RS13230	COG0243	molybdopterin cofactor binding
HKW69_RS13245	COG3119	arylsulfatase activity
HKW69_RS13250	COG0641	radical SAM
HKW69_RS13260	COG4178	(ABC) transporter
HKW69_RS13265	COG4771	TonB-dependent receptor
HKW69_RS13270	COG0612	Peptidase, M16
HKW69_RS13275	COG0076	glutamate decarboxylase activity
HKW69_RS13280	COG0531	amino acid
HKW69_RS13290	COG3706	GGDEF domain
HKW69_RS13290	COG3706	GGDEF domain
HKW69_RS13295	COG2200	EAL domain
HKW69_RS13295	COG2199	diguanylate cyclase activity
HKW69_RS13295	COG2202	Pas domain
HKW69_RS13300	COG1764	response to oxidative stress
HKW69_RS13320	COG1064	alcohol dehydrogenase
HKW69_RS13330	COG3093	addiction module antidote protein HigA
HKW69_RS13335	COG2864	formate dehydrogenase
HKW69_RS13340	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS13350	COG0697	spore germination
HKW69_RS13355	COG2223	nitrite transmembrane transporter activity
HKW69_RS13360	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HKW69_RS13365	COG1140	nitrate reductase beta subunit
HKW69_RS13370	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HKW69_RS13375	COG2181	nitrate reductase activity
HKW69_RS13380	COG0384	phenazine biosynthesis protein PhzF
HKW69_RS13385	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HKW69_RS13390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKW69_RS13430	COG0625	glutathione transferase activity
HKW69_RS13435	COG0625	glutathione transferase activity
HKW69_RS13440	COG1113	amino acid transport
HKW69_RS13450	COG4772	TonB-dependent receptor
HKW69_RS13465	COG1247	-acetyltransferase
HKW69_RS13470	COG3238	Protein conserved in bacteria
HKW69_RS13495	COG1177	transmembrane transport
HKW69_RS13500	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKW69_RS13505	COG3842	ATPase activity
HKW69_RS13510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HKW69_RS13515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKW69_RS13530	COG0826	peptidase U32
HKW69_RS13535	COG1396	sequence-specific DNA binding
HKW69_RS13540	COG3135	benzoate transporter
HKW69_RS13550	COG0500	methyltransferase
HKW69_RS13555	COG1275	C4-dicarboxylate transporter malic acid transport protein
HKW69_RS13560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKW69_RS13565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKW69_RS13570	COG2841	Protein conserved in bacteria
HKW69_RS13580	COG5383	Protein conserved in bacteria
HKW69_RS13585	COG0583	DNA-binding transcription factor activity
HKW69_RS13605	COG3038	cytochrome b561
HKW69_RS13615	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS13620	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HKW69_RS13625	COG1643	Atp-dependent helicase
HKW69_RS13640	COG2267	carboxylic ester hydrolase activity
HKW69_RS13645	COG4589	Belongs to the CDS family
HKW69_RS13650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKW69_RS13655	COG0667	Aldo Keto reductase
HKW69_RS13665	COG3784	Protein of unknown function (DUF1318)
HKW69_RS13675	COG2911	Protein conserved in bacteria
HKW69_RS13680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKW69_RS13685	COG3187	Heat shock protein
HKW69_RS13690	COG3042	response to heat
HKW69_RS13695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HKW69_RS13695	COG1013	pyruvate-flavodoxin oxidoreductase activity
HKW69_RS13695	COG0674	pyruvate-flavodoxin oxidoreductase activity
HKW69_RS13695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKW69_RS13700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HKW69_RS13705	COG0589	response to stress
HKW69_RS13730	COG0513	Belongs to the DEAD box helicase family
HKW69_RS13740	COG3706	GGDEF domain
HKW69_RS13745	COG3706	GGDEF domain
HKW69_RS13750	COG2840	Smr protein MutS2
HKW69_RS13765	COG2207	Transcriptional regulator
HKW69_RS13775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKW69_RS13780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKW69_RS13785	COG0589	response to stress
HKW69_RS13790	COG3182	Iron-regulated membrane protein
HKW69_RS13795	COG0668	transmembrane transport
HKW69_RS13800	COG4166	transmembrane transport
HKW69_RS13805	COG0583	DNA-binding transcription factor activity
HKW69_RS13810	COG1073	alpha beta
HKW69_RS13820	COG0702	epimerase
HKW69_RS13825	COG2866	Carboxypeptidase
HKW69_RS13830	COG4948	Mandelate Racemase Muconate Lactonizing
HKW69_RS13835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HKW69_RS13840	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HKW69_RS13850	COG3106	COG3106 Predicted ATPase
HKW69_RS13855	COG1609	Transcriptional regulator
HKW69_RS13870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKW69_RS13875	COG1554	hydrolase, family 65, central catalytic
HKW69_RS13880	COG0673	inositol 2-dehydrogenase activity
HKW69_RS13885	COG1082	Xylose isomerase domain protein TIM barrel
HKW69_RS13890	COG1063	alcohol dehydrogenase
HKW69_RS13895	COG0395	ABC-type sugar transport system, permease component
HKW69_RS13900	COG1175	transmembrane transport
HKW69_RS13905	COG1653	transport
HKW69_RS13910	COG0366	Alpha amylase catalytic
HKW69_RS13915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKW69_RS13925	COG1983	PspC domain protein
HKW69_RS13935	COG1842	Phage shock protein A
HKW69_RS13940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HKW69_RS13945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKW69_RS13955	COG4166	transmembrane transport
HKW69_RS13960	COG4168	peptide transport system, permease
HKW69_RS13965	COG4171	peptide transport system, permease
HKW69_RS13970	COG4172	Belongs to the ABC transporter superfamily
HKW69_RS13975	COG4172	Belongs to the ABC transporter superfamily
HKW69_RS13980	COG2814	Major facilitator Superfamily
HKW69_RS13990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKW69_RS13995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS14005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HKW69_RS14010	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKW69_RS14010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKW69_RS14025	COG5001	Diguanylate cyclase
HKW69_RS14035	COG1349	DNA-binding transcription factor activity
HKW69_RS14045	COG0023	Translation Initiation Factor
HKW69_RS14055	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HKW69_RS14060	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HKW69_RS14065	COG0671	phosphoesterase, PA-phosphatase related
HKW69_RS14075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKW69_RS14095	COG0583	DNA-binding transcription factor activity
HKW69_RS14100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKW69_RS14110	COG0616	signal peptide processing
HKW69_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS14120	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HKW69_RS14135	COG1187	pseudouridine synthase activity
HKW69_RS14140	COG4907	membrane protein (DUF2207)
HKW69_RS14145	COG0009	L-threonylcarbamoyladenylate synthase
HKW69_RS14150	COG0613	PHP domain protein
HKW69_RS14160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKW69_RS14165	COG0512	Glutamine amidotransferase of anthranilate synthase
HKW69_RS14165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKW69_RS14170	COG0134	indole-3-glycerol-phosphate synthase activity
HKW69_RS14170	COG0135	phosphoribosylanthranilate isomerase activity
HKW69_RS14185	COG3729	General stress protein
HKW69_RS14190	COG3685	Protein conserved in bacteria
HKW69_RS14195	COG3685	Protein conserved in bacteria
HKW69_RS14200	COG3047	cAMP biosynthetic process
HKW69_RS14220	COG1607	acyl-coa hydrolase
HKW69_RS14230	COG2350	Protein conserved in bacteria
HKW69_RS14235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKW69_RS14255	COG4608	Belongs to the ABC transporter superfamily
HKW69_RS14260	COG0444	Belongs to the ABC transporter superfamily
HKW69_RS14265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKW69_RS14270	COG0601	transmembrane transport
HKW69_RS14275	COG4166	transmembrane transport
HKW69_RS14285	COG2095	MarC family integral membrane protein
HKW69_RS14290	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS14290	COG1454	alcohol dehydrogenase
HKW69_RS14300	COG1435	thymidine kinase activity
HKW69_RS14310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKW69_RS14315	COG0745	RESPONSE REGULATOR receiver
HKW69_RS14320	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKW69_RS14330	COG0788	formyltetrahydrofolate deformylase activity
HKW69_RS14355	COG2181	nitrate reductase activity
HKW69_RS14360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HKW69_RS14365	COG1140	nitrate reductase beta subunit
HKW69_RS14370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HKW69_RS14375	COG2223	nitrite transmembrane transporter activity
HKW69_RS14380	COG3850	Histidine kinase
HKW69_RS14385	COG2197	response regulator
HKW69_RS14390	COG4932	domain protein
HKW69_RS14395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HKW69_RS14400	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HKW69_RS14405	COG4572	Cation transport regulator
HKW69_RS14410	COG0387	Pfam Sodium calcium exchanger
HKW69_RS14425	COG2912	Transglutaminase-like superfamily
HKW69_RS14430	COG3094	Invasion gene expression up-regulator, SirB
HKW69_RS14435	COG2890	protein-(glutamine-N5) methyltransferase activity
HKW69_RS14460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKW69_RS14465	COG0659	secondary active sulfate transmembrane transporter activity
HKW69_RS14480	COG0012	GTP binding
HKW69_RS14490	COG3284	Transcriptional regulator
HKW69_RS14495	COG2376	Dihydroxyacetone kinase
HKW69_RS14500	COG1461	Dihydroxyacetone kinase
HKW69_RS14505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS14505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKW69_RS14505	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HKW69_RS14530	COG1120	ATPase activity
HKW69_RS14535	COG0500	methyltransferase
HKW69_RS14540	COG0157	Belongs to the NadC ModD family
HKW69_RS14555	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HKW69_RS14565	COG1619	proteins homologs of microcin C7 resistance protein MccF
HKW69_RS14575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKW69_RS14585	COG2719	SpoVR family
HKW69_RS14605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKW69_RS14610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKW69_RS14625	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKW69_RS14650	COG2894	cell division
HKW69_RS14725	COG2200	EAL domain
HKW69_RS14730	COG0789	Transcriptional regulator
HKW69_RS14735	COG5562	phage envelope protein
HKW69_RS14745	COG0538	isocitrate dehydrogenase activity
HKW69_RS14755	COG1121	(ABC) transporter
HKW69_RS14760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKW69_RS14765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKW69_RS14770	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HKW69_RS14775	COG5301	cellulose 1,4-beta-cellobiosidase activity
HKW69_RS14880	COG4220	transposase activity
HKW69_RS14905	COG3772	lysozyme
HKW69_RS15045	COG0582	viral genome integration into host DNA
HKW69_RS15050	COG0538	isocitrate dehydrogenase activity
HKW69_RS15055	COG1187	pseudouridine synthase activity
HKW69_RS15075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKW69_RS15085	COG2205	protein histidine kinase activity
HKW69_RS15090	COG2850	peptidyl-arginine hydroxylation
HKW69_RS15100	COG3842	ATPase activity
HKW69_RS15110	COG1177	transmembrane transport
HKW69_RS15115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HKW69_RS15125	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HKW69_RS15130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKW69_RS15140	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKW69_RS15150	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKW69_RS15160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKW69_RS15165	COG1388	LysM domain
HKW69_RS15165	COG1376	ErfK ybiS ycfS ynhG family protein
HKW69_RS15175	COG1309	transcriptional regulator
HKW69_RS15180	COG3134	Outer membrane lipoprotein
HKW69_RS15185	COG1252	NADH dehydrogenase
HKW69_RS15205	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HKW69_RS15210	COG5633	Lipoprotein
HKW69_RS15215	COG0537	adenosine 5'-monophosphoramidase activity
HKW69_RS15225	COG1263	PTS System
HKW69_RS15225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS15230	COG0084	hydrolase, TatD family'
HKW69_RS15235	COG0470	DNA polymerase III
HKW69_RS15245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKW69_RS15250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKW69_RS15255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKW69_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS15270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKW69_RS15290	COG1399	metal-binding, possibly nucleic acid-binding protein
HKW69_RS15295	COG0424	maF-like protein
HKW69_RS15300	COG0564	pseudouridine synthase activity
HKW69_RS15305	COG1530	ribonuclease E activity
HKW69_RS15310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HKW69_RS15315	COG1256	bacterial-type flagellum assembly
HKW69_RS15320	COG3951	Flagellar rod assembly protein muramidase FlgJ
HKW69_RS15320	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKW69_RS15335	COG4786	Flagellar basal body rod
HKW69_RS15340	COG4787	bacterial-type flagellum-dependent cell motility
HKW69_RS15345	COG1749	Flagellar hook protein flgE
HKW69_RS15350	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HKW69_RS15355	COG1558	bacterial-type flagellum-dependent cell motility
HKW69_RS15360	COG1815	bacterial-type flagellum-dependent cell motility
HKW69_RS15365	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HKW69_RS15370	COG2747	anti-sigma28 factor FlgM
HKW69_RS15375	COG3418	PFAM FlgN family protein
HKW69_RS15380	COG0728	peptidoglycan biosynthetic process
HKW69_RS15385	COG0673	inositol 2-dehydrogenase activity
HKW69_RS15395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKW69_RS15405	COG2999	glutathione oxidoreductase activity
HKW69_RS15440	COG3038	cytochrome b561
HKW69_RS15445	COG2353	YceI-like domain
HKW69_RS15455	COG1560	Kdo2-lipid A biosynthetic process
HKW69_RS15470	COG5645	(Lipo)protein
HKW69_RS15475	COG2943	transferase activity, transferring hexosyl groups
HKW69_RS15495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HKW69_RS15520	COG2197	response regulator
HKW69_RS15535	COG1462	curli production assembly transport component CsgG
HKW69_RS15545	COG3381	protein complex oligomerization
HKW69_RS15570	COG0457	Tetratricopeptide repeat
HKW69_RS15575	COG0726	polysaccharide deacetylase
HKW69_RS15575	COG1649	PFAM Uncharacterised BCR, COG1649
HKW69_RS15580	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS15585	COG3658	cytochrome
HKW69_RS15590	COG1702	phosphate starvation-inducible protein PhoH
HKW69_RS15610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKW69_RS15620	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKW69_RS15620	COG0506	proline dehydrogenase activity
HKW69_RS15620	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKW69_RS15625	COG1309	transcriptional regulator
HKW69_RS15660	COG2233	PERMEase
HKW69_RS15665	COG3729	General stress protein
HKW69_RS15700	COG0243	molybdopterin cofactor binding
HKW69_RS15705	COG3005	denitrification pathway
HKW69_RS15710	COG0745	RESPONSE REGULATOR receiver
HKW69_RS15715	COG1879	ABC-type sugar transport system periplasmic component
HKW69_RS15720	COG0784	Response regulator, receiver
HKW69_RS15720	COG2198	Histidine kinase
HKW69_RS15720	COG2205	protein histidine kinase activity
HKW69_RS15725	COG0348	domain, Protein
HKW69_RS15750	COG1278	Cold shock
HKW69_RS15755	COG1278	Cold shock
HKW69_RS15770	COG1294	oxidase, subunit
HKW69_RS15775	COG1271	oxidase subunit
HKW69_RS15780	COG1773	rubredoxin
HKW69_RS15785	COG1999	signal sequence binding
HKW69_RS15790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HKW69_RS15795	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HKW69_RS15800	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HKW69_RS15805	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HKW69_RS15815	COG0670	Belongs to the BI1 family
HKW69_RS15820	COG2920	part of a sulfur-relay system
HKW69_RS15825	COG1254	Belongs to the acylphosphatase family
HKW69_RS15840	COG1832	CoA-binding protein
HKW69_RS15855	COG0210	DNA helicase
HKW69_RS15860	COG3304	Inner membrane component domain
HKW69_RS15865	COG1289	transmembrane transporter activity
HKW69_RS15870	COG3070	regulator of competence-specific genes
HKW69_RS15880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HKW69_RS15880	COG2885	chlorophyll binding
HKW69_RS15890	COG1067	ATP-dependent peptidase activity
HKW69_RS15900	COG3130	regulation of translation
HKW69_RS15905	COG3009	Protein conserved in bacteria
HKW69_RS15910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKW69_RS15910	COG3008	intermembrane lipid transfer
HKW69_RS15915	COG2995	paraquat-inducible protein a
HKW69_RS15920	COG0488	(ABC) transporter
HKW69_RS15930	COG3217	Mosc domain protein beta barrel domain protein
HKW69_RS15930	COG0633	Ferredoxin
HKW69_RS15945	COG0431	NADPH-dependent FMN reductase
HKW69_RS15950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKW69_RS15960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKW69_RS15970	COG0308	aminopeptidase N
HKW69_RS15990	COG1448	Aminotransferase
HKW69_RS15995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKW69_RS16000	COG3108	Peptidase M15
HKW69_RS16005	COG2989	Protein conserved in bacteria
HKW69_RS16015	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HKW69_RS16025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKW69_RS16030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HKW69_RS16035	COG3173	Aminoglycoside phosphotransferase
HKW69_RS16050	COG3214	Protein conserved in bacteria
HKW69_RS16065	COG0658	competence protein
HKW69_RS16065	COG2333	competence protein COMEC
HKW69_RS16075	COG0539	negative regulation of cytoplasmic translation
HKW69_RS16085	COG0501	Belongs to the peptidase M48B family
HKW69_RS16100	COG2323	membrane
HKW69_RS16110	COG2116	formate transmembrane transporter activity
HKW69_RS16115	COG1882	Formate acetyltransferase
HKW69_RS16120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKW69_RS16130	COG1335	isochorismatase
HKW69_RS16135	COG3302	dmso reductase anchor subunit
HKW69_RS16140	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS16145	COG0243	molybdopterin cofactor binding
HKW69_RS16155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKW69_RS16165	COG1674	ftsk spoiiie
HKW69_RS16165	COG1178	ABC-type Fe3 transport system permease component
HKW69_RS16170	COG1522	sequence-specific DNA binding
HKW69_RS16175	COG0492	ferredoxin-NADP+ reductase activity
HKW69_RS16180	COG4988	ABC transporter
HKW69_RS16185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HKW69_RS16205	COG0542	response to heat
HKW69_RS16215	COG1278	Cold shock
HKW69_RS16225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS16230	COG2990	Protein conserved in bacteria
HKW69_RS16235	COG3593	DNA synthesis involved in DNA repair
HKW69_RS16245	COG2431	L-lysine efflux transmembrane transporter activity
HKW69_RS16255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKW69_RS16260	COG0028	Belongs to the TPP enzyme family
HKW69_RS16265	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HKW69_RS16270	COG0702	epimerase
HKW69_RS16275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKW69_RS16280	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKW69_RS16295	COG1126	abc transporter atp-binding protein
HKW69_RS16300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS16305	COG4215	(ABC) transporter
HKW69_RS16310	COG4160	amino acid transport
HKW69_RS16315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS16330	COG1177	transmembrane transport
HKW69_RS16335	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKW69_RS16340	COG3842	ATPase activity
HKW69_RS16345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HKW69_RS16360	COG0778	Nitroreductase
HKW69_RS16370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKW69_RS16385	COG3226	Transcriptional regulator
HKW69_RS16390	COG0738	Major facilitator superfamily
HKW69_RS16395	COG0561	phosphatase activity
HKW69_RS16405	COG2814	Major facilitator Superfamily
HKW69_RS16410	COG0671	phosphoesterase, PA-phosphatase related
HKW69_RS16415	COG1349	DNA-binding transcription factor activity
HKW69_RS16420	COG1686	Belongs to the peptidase S11 family
HKW69_RS16425	COG0625	glutathione transferase activity
HKW69_RS16430	COG2133	pyrroloquinoline quinone binding
HKW69_RS16445	COG2199	diguanylate cyclase activity
HKW69_RS16450	COG2200	EAL domain
HKW69_RS16475	COG1446	asparaginase
HKW69_RS16480	COG0303	'Molybdopterin
HKW69_RS16485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HKW69_RS16490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKW69_RS16495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKW69_RS16500	COG1882	Formate acetyltransferase
HKW69_RS16505	COG0561	phosphatase activity
HKW69_RS16510	COG0488	(ABC) transporter
HKW69_RS16515	COG1376	ErfK ybiS ycfS ynhG family protein
HKW69_RS16520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HKW69_RS16525	COG1321	iron dependent repressor
HKW69_RS16535	COG2194	sulfuric ester hydrolase activity
HKW69_RS16540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HKW69_RS16550	COG5006	permease, DMT superfamily
HKW69_RS16560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS16565	COG0765	amino acid transport
HKW69_RS16570	COG1126	abc transporter atp-binding protein
HKW69_RS16575	COG0668	transmembrane transport
HKW69_RS16600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HKW69_RS16610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HKW69_RS16615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKW69_RS16620	COG1199	ATP-dependent helicase activity
HKW69_RS16630	COG0513	Belongs to the DEAD box helicase family
HKW69_RS16635	COG1309	transcriptional regulator
HKW69_RS16645	COG1131	(ABC) transporter
HKW69_RS16650	COG0842	Transport permease protein
HKW69_RS16655	COG0842	Transport permease protein
HKW69_RS16665	COG3568	Endonuclease Exonuclease Phosphatase
HKW69_RS16670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKW69_RS16675	COG0392	lysyltransferase activity
HKW69_RS16680	COG0670	Belongs to the BI1 family
HKW69_RS16685	COG0670	Belongs to the BI1 family
HKW69_RS16690	COG0314	molybdopterin synthase activity
HKW69_RS16695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HKW69_RS16705	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKW69_RS16715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HKW69_RS16725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HKW69_RS16730	COG2226	methyltransferase
HKW69_RS16745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HKW69_RS16755	COG1881	PFAM PEBP family protein
HKW69_RS16855	COG1783	phage Terminase large subunit
HKW69_RS17005	COG4712	double-strand break repair protein
HKW69_RS17060	COG0582	viral genome integration into host DNA
HKW69_RS17065	COG4677	pectinesterase activity
HKW69_RS17070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKW69_RS17075	COG0471	metal ion transport
HKW69_RS17080	COG2828	Protein conserved in bacteria
HKW69_RS17085	COG0583	DNA-binding transcription factor activity
HKW69_RS17095	COG0561	phosphatase activity
HKW69_RS17105	COG4149	molybdate abc transporter
HKW69_RS17110	COG0725	ABC transporter, periplasmic molybdate-binding protein
HKW69_RS17120	COG2005	Transcriptional regulator
HKW69_RS17120	COG3585	molybdate ion transport
HKW69_RS17125	COG1119	ATPase activity
HKW69_RS17130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKW69_RS17135	COG1085	galactose-1-phosphate uridylyltransferase
HKW69_RS17145	COG2017	converts alpha-aldose to the beta-anomer
HKW69_RS17155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKW69_RS17165	COG1230	cation diffusion facilitator family transporter
HKW69_RS17170	COG3201	nicotinamide mononucleotide transporter
HKW69_RS17215	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HKW69_RS17220	COG2885	chlorophyll binding
HKW69_RS17230	COG3064	Membrane
HKW69_RS17235	COG0848	biopolymer transport protein
HKW69_RS17240	COG0811	peptide transport
HKW69_RS17245	COG0824	Thioesterase
HKW69_RS17255	COG4890	Cyd operon protein YbgT
HKW69_RS17260	COG1294	oxidase, subunit
HKW69_RS17265	COG1271	oxidase subunit
HKW69_RS17275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKW69_RS17285	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKW69_RS17290	COG0567	Dehydrogenase, E1 component
HKW69_RS17295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKW69_RS17300	COG1053	succinate dehydrogenase
HKW69_RS17305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HKW69_RS17310	COG2009	succinate dehydrogenase
HKW69_RS17320	COG0372	Belongs to the citrate synthase family
HKW69_RS17330	COG3180	Ammonia monooxygenase
HKW69_RS17345	COG1984	allophanate hydrolase subunit 2
HKW69_RS17350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HKW69_RS17355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKW69_RS17365	COG0415	Belongs to the DNA photolyase family
HKW69_RS17370	COG3272	Protein of unknown function (DUF1722)
HKW69_RS17400	COG2205	protein histidine kinase activity
HKW69_RS17405	COG0745	RESPONSE REGULATOR receiver
HKW69_RS17415	COG1982	Orn Lys Arg decarboxylase major
HKW69_RS17420	COG0531	amino acid
HKW69_RS17425	COG0033	Phosphoglucomutase
HKW69_RS17430	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HKW69_RS17435	COG0596	Alpha beta hydrolase
HKW69_RS17445	COG0716	FMN binding
HKW69_RS17455	COG0735	belongs to the Fur family
HKW69_RS17475	COG1349	DNA-binding transcription factor activity
HKW69_RS17480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HKW69_RS17485	COG3395	kinase activity
HKW69_RS17490	COG1454	alcohol dehydrogenase
HKW69_RS17495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKW69_RS17500	COG0861	Integral membrane protein TerC family
HKW69_RS17520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS17520	COG2190	(PTS) system
HKW69_RS17520	COG1263	PTS System
HKW69_RS17530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKW69_RS17535	COG1940	carbohydrate kinase activity
HKW69_RS17535	COG1846	Transcriptional regulator
HKW69_RS17540	COG0647	UMP catabolic process
HKW69_RS17545	COG0367	asparagine synthase
HKW69_RS17585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKW69_RS17595	COG1702	phosphate starvation-inducible protein PhoH
HKW69_RS17605	COG4535	Mg2 and Co2 transporter CorC
HKW69_RS17610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HKW69_RS17620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKW69_RS17625	COG0765	amino acid transport
HKW69_RS17630	COG0765	amino acid transport
HKW69_RS17635	COG1126	abc transporter atp-binding protein
HKW69_RS17645	COG2888	peptidyl-tyrosine sulfation
HKW69_RS17660	COG1466	dna polymerase III delta subunit
HKW69_RS17670	COG0406	alpha-ribazole phosphatase activity
HKW69_RS17675	COG0799	negative regulation of ribosome biogenesis
HKW69_RS17685	COG0768	penicillin binding
HKW69_RS17690	COG0772	Belongs to the SEDS family
HKW69_RS17695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKW69_RS17700	COG1686	Belongs to the peptidase S11 family
HKW69_RS17720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKW69_RS17725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKW69_RS17745	COG3069	C4-dicarboxylate transmembrane transporter activity
HKW69_RS17750	COG4565	transcriptional regulatory protein
HKW69_RS17755	COG3290	protein histidine kinase activity
HKW69_RS17760	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HKW69_RS17770	COG2301	Belongs to the HpcH HpaI aldolase family
HKW69_RS17775	COG3051	citrate lyase alpha subunit
HKW69_RS17790	COG0471	metal ion transport
HKW69_RS17795	COG3719	Belongs to the RNase T2 family
HKW69_RS17800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKW69_RS17805	COG0589	response to stress
HKW69_RS17810	COG3634	alkyl hydroperoxide reductase activity
HKW69_RS17815	COG0450	alkyl hydroperoxide reductase
HKW69_RS17820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKW69_RS17825	COG0583	DNA-binding transcription factor activity
HKW69_RS17830	COG3969	phosphoadenosine phosphosulfate
HKW69_RS17835	COG1475	DNA binding
HKW69_RS17845	COG0371	Dehydrogenase
HKW69_RS17850	COG2879	small protein
HKW69_RS17855	COG1966	Carbon starvation protein
HKW69_RS17860	COG2050	protein possibly involved in aromatic compounds catabolism
HKW69_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS17870	COG1535	isochorismatase
HKW69_RS17870	COG3433	isochorismatase activity
HKW69_RS17875	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKW69_RS17880	COG1169	isochorismate synthase
HKW69_RS17885	COG4592	Periplasmic binding protein
HKW69_RS17895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS17900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS17905	COG1120	ATPase activity
HKW69_RS17910	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HKW69_RS17915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKW69_RS17915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HKW69_RS17920	COG3251	PFAM MbtH domain protein
HKW69_RS17925	COG2382	esterase
HKW69_RS17935	COG4771	TonB-dependent receptor
HKW69_RS17940	COG2977	Belongs to the P-Pant transferase superfamily
HKW69_RS17960	COG2315	Protein conserved in bacteria
HKW69_RS17965	COG0778	Nitroreductase
HKW69_RS17970	COG0668	transmembrane transport
HKW69_RS17975	COG1113	amino acid transport
HKW69_RS17980	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKW69_RS17985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS17990	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS17995	COG1538	Outer membrane efflux protein
HKW69_RS18000	COG0745	RESPONSE REGULATOR receiver
HKW69_RS18005	COG5002	protein histidine kinase activity
HKW69_RS18010	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS18015	COG4783	chaperone-mediated protein folding
HKW69_RS18025	COG4571	Outer membrane protease
HKW69_RS18030	COG0500	methyltransferase
HKW69_RS18060	COG2501	S4 domain
HKW69_RS18065	COG1988	membrane-bound metal-dependent
HKW69_RS18075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKW69_RS18090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKW69_RS18095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HKW69_RS18100	COG0549	Belongs to the carbamate kinase family
HKW69_RS18110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKW69_RS18115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKW69_RS18120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HKW69_RS18125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKW69_RS18130	COG3257	ureidoglycine aminohydrolase activity
HKW69_RS18135	COG1929	Belongs to the glycerate kinase type-1 family
HKW69_RS18140	COG2233	PERMEase
HKW69_RS18150	COG1953	Uracil, thiamine, allantoin
HKW69_RS18155	COG2084	Dehydrogenase
HKW69_RS18160	COG3622	Belongs to the hyi family
HKW69_RS18165	COG3960	tartronate-semialdehyde synthase activity
HKW69_RS18170	COG1414	Transcriptional regulator
HKW69_RS18190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HKW69_RS18195	COG4181	ATPase activity
HKW69_RS18200	COG2755	lipolytic protein G-D-S-L family
HKW69_RS18205	COG0300	oxidoreductase activity
HKW69_RS18210	COG3118	belongs to the thioredoxin family
HKW69_RS18215	COG0390	transport system, permease component
HKW69_RS18220	COG4619	ABC transporter
HKW69_RS18225	COG0330	HflC and HflK could
HKW69_RS18230	COG1585	Membrane protein implicated in regulation of membrane protease activity
HKW69_RS18240	COG0789	Transcriptional regulator
HKW69_RS18245	COG0531	amino acid
HKW69_RS18255	COG2217	Heavy metal translocating P-type atpase
HKW69_RS18260	COG3093	addiction module antidote protein HigA
HKW69_RS18265	COG3549	Plasmid maintenance system killer
HKW69_RS18270	COG3735	TraB family
HKW69_RS18275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKW69_RS18290	COG0737	Belongs to the 5'-nucleotidase family
HKW69_RS18295	COG2223	nitrite transmembrane transporter activity
HKW69_RS18300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKW69_RS18300	COG4651	solute:proton antiporter activity
HKW69_RS18305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS18340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKW69_RS18350	COG2832	Protein of unknown function (DUF454)
HKW69_RS18355	COG3923	Primosomal replication protein n
HKW69_RS18365	COG3264	Mechanosensitive ion channel
HKW69_RS18365	COG1196	nuclear chromosome segregation
HKW69_RS18370	COG1309	transcriptional regulator
HKW69_RS18375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKW69_RS18380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKW69_RS18400	COG0110	maltose O-acetyltransferase activity
HKW69_RS18410	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HKW69_RS18415	COG5507	3-demethylubiquinone-9 3-methyltransferase
HKW69_RS18425	COG3695	enzyme binding
HKW69_RS18430	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HKW69_RS18435	COG1946	Acyl-CoA thioesterase
HKW69_RS18440	COG0004	ammonium transporteR
HKW69_RS18445	COG0347	Belongs to the P(II) protein family
HKW69_RS18450	COG1132	(ABC) transporter
HKW69_RS18455	COG1132	(ABC) transporter
HKW69_RS18460	COG1522	sequence-specific DNA binding
HKW69_RS18470	COG4533	DNA binding
HKW69_RS18480	COG0824	Thioesterase
HKW69_RS18485	COG1555	photosystem II stabilization
HKW69_RS18490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKW69_RS18495	COG0776	regulation of translation
HKW69_RS18500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKW69_RS18520	COG0271	Belongs to the BolA IbaG family
HKW69_RS18525	COG3056	Lipoprotein
HKW69_RS18530	COG2223	nitrite transmembrane transporter activity
HKW69_RS18535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKW69_RS18540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKW69_RS18545	COG1845	cytochrome c oxidase, subunit III
HKW69_RS18550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HKW69_RS18560	COG2814	Major facilitator Superfamily
HKW69_RS18570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKW69_RS18575	COG0693	protein deglycase activity
HKW69_RS18590	COG0142	geranyltranstransferase activity
HKW69_RS18600	COG0667	Aldo Keto reductase
HKW69_RS18605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HKW69_RS18610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HKW69_RS18625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKW69_RS18625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKW69_RS18635	COG4238	major outer membrane lipoprotein
HKW69_RS18640	COG3248	Nucleoside-binding outer membrane protein
HKW69_RS18645	COG1403	HNH endonuclease
HKW69_RS18650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKW69_RS18655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKW69_RS18660	COG1862	Preprotein translocase
HKW69_RS18680	COG0366	Alpha amylase catalytic
HKW69_RS18685	COG1113	amino acid transport
HKW69_RS18690	COG1114	Component of the transport system for branched-chain amino acids
HKW69_RS18695	COG5002	protein histidine kinase activity
HKW69_RS18700	COG0745	RESPONSE REGULATOR receiver
HKW69_RS18705	COG0420	3'-5' exonuclease activity
HKW69_RS18710	COG0419	ATPase involved in DNA repair
HKW69_RS18715	COG2814	Major facilitator Superfamily
HKW69_RS18720	COG1940	carbohydrate kinase activity
HKW69_RS18745	COG4126	flavin adenine dinucleotide binding
HKW69_RS18765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKW69_RS18780	COG1785	Belongs to the alkaline phosphatase family
HKW69_RS18795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKW69_RS18815	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HKW69_RS18820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKW69_RS18825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKW69_RS18830	COG3468	outer membrane autotransporter barrel domain protein
HKW69_RS18835	COG0113	porphobilinogen synthase activity
HKW69_RS18840	COG2175	clavaminate synthase activity
HKW69_RS18845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKW69_RS18855	COG4521	taurine ABC transporter
HKW69_RS18860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKW69_RS18865	COG1215	transferase activity, transferring glycosyl groups
HKW69_RS18895	COG3122	Protein conserved in bacteria
HKW69_RS18905	COG1609	Transcriptional regulator
HKW69_RS18915	COG2223	nitrite transmembrane transporter activity
HKW69_RS18920	COG0110	maltose O-acetyltransferase activity
HKW69_RS18930	COG0402	S-adenosylhomocysteine deaminase activity
HKW69_RS18935	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKW69_RS18940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKW69_RS18945	COG2079	MmgE PrpD family protein
HKW69_RS18950	COG0372	Belongs to the citrate synthase family
HKW69_RS18955	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HKW69_RS18960	COG3829	transcription factor binding
HKW69_RS18970	COG1280	lysine exporter protein (LysE YggA)
HKW69_RS18980	COG1064	alcohol dehydrogenase
HKW69_RS18985	COG0402	S-adenosylhomocysteine deaminase activity
HKW69_RS18990	COG0549	Belongs to the carbamate kinase family
HKW69_RS18995	COG1304	FMN binding
HKW69_RS19000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKW69_RS19020	COG3468	outer membrane autotransporter barrel domain protein
HKW69_RS19035	COG1556	Lactate utilization protein
HKW69_RS19040	COG1139	Iron-sulfur cluster binding protein
HKW69_RS19045	COG0247	lactate metabolic process
HKW69_RS19050	COG2207	Transcriptional regulator
HKW69_RS19055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKW69_RS19065	COG3059	membrane
HKW69_RS19070	COG0656	L-ascorbic acid biosynthetic process
HKW69_RS19075	COG3708	Transcriptional regulator
HKW69_RS19075	COG2207	Transcriptional regulator
HKW69_RS19080	COG4932	domain protein
HKW69_RS19080	COG2373	Large extracellular alpha-helical protein
HKW69_RS19080	COG1388	LysM domain
HKW69_RS19085	COG0656	L-ascorbic acid biosynthetic process
HKW69_RS19090	COG0667	Aldo Keto reductase
HKW69_RS19100	COG0583	DNA-binding transcription factor activity
HKW69_RS19105	COG1073	alpha beta
HKW69_RS19110	COG1902	pentaerythritol trinitrate reductase activity
HKW69_RS19150	COG3188	usher protein
HKW69_RS19165	COG0727	PFAM Uncharacterised protein family (UPF0153)
HKW69_RS19175	COG3477	response to acidic pH
HKW69_RS19205	COG0582	viral genome integration into host DNA
HKW69_RS19245	COG2003	Belongs to the UPF0758 family
HKW69_RS19260	COG3468	outer membrane autotransporter barrel domain protein
HKW69_RS19285	COG0531	amino acid
HKW69_RS19300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKW69_RS19305	COG0583	DNA-binding transcription factor activity
HKW69_RS19315	COG3436	PFAM IS66 Orf2 family protein
HKW69_RS19345	COG0523	cobalamin synthesis protein
HKW69_RS19355	COG4771	TonB-dependent receptor
HKW69_RS19395	COG2819	hydrolase of the alpha beta superfamily
HKW69_RS19440	COG3539	Fimbrial protein
HKW69_RS19495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKW69_RS19500	COG4644	lycopene metabolic process
HKW69_RS19585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HKW69_RS19605	COG2195	Cleaves the N-terminal amino acid of tripeptides
HKW69_RS19610	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKW69_RS19615	COG1690	Belongs to the RtcB family
HKW69_RS19620	COG0454	-acetyltransferase
HKW69_RS19630	COG2161	toxin-antitoxin pair type II binding
HKW69_RS19655	COG1943	Transposase
HKW69_RS19660	COG0791	NLP P60 protein
HKW69_RS19665	COG3034	peptidoglycan biosynthetic process
HKW69_RS19670	COG0121	glutamine amidotransferase
HKW69_RS19680	COG1960	acyl-CoA dehydrogenase activity
HKW69_RS19690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKW69_RS19730	COG3501	Rhs element vgr protein
HKW69_RS19825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKW69_RS19835	COG2226	methyltransferase
HKW69_RS19845	COG1388	LysM domain
HKW69_RS19845	COG0741	lytic transglycosylase activity
HKW69_RS19850	COG2226	methyltransferase
HKW69_RS19860	COG0583	DNA-binding transcription factor activity
HKW69_RS19865	COG0656	L-ascorbic acid biosynthetic process
HKW69_RS19900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HKW69_RS19910	COG2011	ABC-type metal ion transport system permease component
HKW69_RS19915	COG1464	Belongs to the NlpA lipoprotein family
HKW69_RS19925	COG1720	tRNA m6t6A37 methyltransferase activity
HKW69_RS19935	COG0791	NLP P60 protein
HKW69_RS19940	COG3015	lipoprotein NlpE involved in copper resistance
HKW69_RS19945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKW69_RS19950	COG4681	YaeQ
HKW69_RS19960	COG4568	rho-dependent transcription termination
HKW69_RS19965	COG0037	tRNA processing
HKW69_RS19970	COG0346	lactoylglutathione lyase activity
HKW69_RS19985	COG0587	DNA-directed DNA polymerase activity
HKW69_RS20010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKW69_RS20015	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HKW69_RS20025	COG0750	zinc metalloprotease
HKW69_RS20030	COG0575	Belongs to the CDS family
HKW69_RS20035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKW69_RS20040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HKW69_RS20065	COG0024	Methionine aminopeptidase
HKW69_RS20085	COG3835	regulator
HKW69_RS20090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKW69_RS20105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKW69_RS20110	COG2860	membrane
HKW69_RS20135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKW69_RS20140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKW69_RS20145	COG1120	ATPase activity
HKW69_RS20150	COG4774	siderophore transport
HKW69_RS20155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKW69_RS20160	COG1643	Atp-dependent helicase
HKW69_RS20165	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HKW69_RS20175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HKW69_RS20180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKW69_RS20185	COG0617	tRNA 3'-terminal CCA addition
HKW69_RS20190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKW69_RS20195	COG3539	Fimbrial protein
HKW69_RS20200	COG3121	Chaperone
HKW69_RS20220	COG3539	Fimbrial protein
HKW69_RS20225	COG3539	Fimbrial protein
HKW69_RS20230	COG3539	Fimbrial protein
HKW69_RS20235	COG3539	Fimbrial protein
HKW69_RS20250	COG5464	transposase or invertase
HKW69_RS20260	COG0726	polysaccharide deacetylase
HKW69_RS20265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS20270	COG0842	Transport permease protein
HKW69_RS20275	COG1131	(ABC) transporter
HKW69_RS20280	COG0288	reversible hydration of carbon dioxide
HKW69_RS20285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HKW69_RS20290	COG4993	Dehydrogenase
HKW69_RS20295	COG2132	Multicopper oxidase
HKW69_RS20320	COG1049	propionate catabolic process, 2-methylcitrate cycle
HKW69_RS20325	COG3064	Membrane
HKW69_RS20330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKW69_RS20335	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKW69_RS20340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HKW69_RS20345	COG2186	Transcriptional regulator
HKW69_RS20375	COG3157	Type VI secretion system effector, Hcp
HKW69_RS20380	COG1113	amino acid transport
HKW69_RS20385	COG3725	Membrane protein required for beta-lactamase induction
HKW69_RS20390	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKW69_RS20395	COG0157	Belongs to the NadC ModD family
HKW69_RS20400	COG4969	Belongs to the N-Me-Phe pilin family
HKW69_RS20405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKW69_RS20410	COG1459	type II secretion system
HKW69_RS20420	COG0237	dephospho-CoA kinase activity
HKW69_RS20435	COG0494	nUDIX hydrolase
HKW69_RS20455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKW69_RS20460	COG0849	cell division
HKW69_RS20465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HKW69_RS20470	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKW69_RS20485	COG0772	Belongs to the SEDS family
HKW69_RS20500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKW69_RS20505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKW69_RS20510	COG0768	penicillin binding
HKW69_RS20515	COG3116	cell division
HKW69_RS20530	COG1609	Transcriptional regulator
HKW69_RS20540	COG0440	acetolactate synthase activity
HKW69_RS20545	COG0028	Belongs to the TPP enzyme family
HKW69_RS20550	COG0583	DNA-binding transcription factor activity
HKW69_RS20565	COG0473	3-isopropylmalate dehydrogenase activity
HKW69_RS20590	COG4143	(ABC) transporter
HKW69_RS20595	COG1178	ABC-type Fe3 transport system permease component
HKW69_RS20605	COG0586	Pfam SNARE associated Golgi protein
HKW69_RS20620	COG4977	sequence-specific DNA binding
HKW69_RS20635	COG0235	Class ii aldolase
HKW69_RS20640	COG0417	DNA replication proofreading
HKW69_RS20650	COG0564	pseudouridine synthase activity
HKW69_RS20655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HKW69_RS20665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKW69_RS20700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKW69_RS20715	COG2271	Major facilitator Superfamily
HKW69_RS20720	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HKW69_RS20725	COG0644	oxidoreductase
HKW69_RS20775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HKW69_RS20780	COG0505	Belongs to the CarA family
HKW69_RS20800	COG1047	Peptidyl-prolyl cis-trans
HKW69_RS20815	COG0196	riboflavin kinase activity
HKW69_RS20830	COG0583	DNA-binding transcription factor activity
HKW69_RS20845	COG3119	arylsulfatase activity
HKW69_RS20875	COG4735	regulation of single-species biofilm formation
HKW69_RS20880	COG1584	GPR1 FUN34 yaaH family protein
HKW69_RS20885	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKW69_RS20895	COG1115	amino acid carrier protein
HKW69_RS20910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HKW69_RS20920	COG0527	aspartate kinase activity
HKW69_RS20920	COG0460	homoserine dehydrogenase
HKW69_RS20930	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HKW69_RS20940	COG0745	RESPONSE REGULATOR receiver
HKW69_RS20945	COG4452	Inner membrane protein CreD
HKW69_RS20950	COG2205	protein histidine kinase activity
HKW69_RS20955	COG0745	RESPONSE REGULATOR receiver
HKW69_RS20960	COG3045	CreA protein
HKW69_RS20965	COG3708	Transcriptional regulator
HKW69_RS20965	COG2207	Transcriptional regulator
HKW69_RS20985	COG0741	lytic transglycosylase activity
HKW69_RS20990	COG0488	(ABC) transporter
HKW69_RS21000	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HKW69_RS21005	COG3172	ATPase kinase involved in NAD metabolism
HKW69_RS21005	COG1056	cytidyltransferase-related domain
HKW69_RS21010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HKW69_RS21015	COG0560	Phosphoserine phosphatase
HKW69_RS21055	COG1328	CTP reductase activity
HKW69_RS21060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKW69_RS21065	COG0084	hydrolase, TatD family'
HKW69_RS21070	COG4667	esterase of the alpha-beta hydrolase superfamily
HKW69_RS21080	COG2823	Periplasmic or secreted lipoprotein
HKW69_RS21110	COG5301	cellulose 1,4-beta-cellobiosidase activity
HKW69_RS21180	COG0740	serine-type endopeptidase activity
HKW69_RS21255	COG1403	HNH endonuclease
HKW69_RS21265	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HKW69_RS21275	COG4725	Belongs to the MT-A70-like family
HKW69_RS21285	COG1846	Transcriptional regulator
HKW69_RS21330	COG5532	Uncharacterized conserved protein (DUF2303)
HKW69_RS21335	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HKW69_RS21360	COG1011	Hydrolase
HKW69_RS21365	COG0456	acetyltransferase
HKW69_RS21370	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HKW69_RS21400	COG4114	ferric iron reductase
HKW69_RS21405	COG2197	response regulator
HKW69_RS21410	COG2197	response regulator
HKW69_RS21415	COG2966	Psort location CytoplasmicMembrane, score
HKW69_RS21430	COG1484	DNA-dependent DNA replication
HKW69_RS21445	COG1063	alcohol dehydrogenase
HKW69_RS21450	COG1802	Transcriptional regulator
HKW69_RS21455	COG0025	NhaP-type Na H and K H
HKW69_RS21470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HKW69_RS21475	COG0840	transmembrane signaling receptor activity
HKW69_RS21480	COG1966	Carbon starvation protein
HKW69_RS21485	COG2879	small protein
HKW69_RS21490	COG0523	cobalamin synthesis protein
HKW69_RS21525	COG5457	Domain of unknown function (DUF1127)
HKW69_RS21535	COG2733	membrane
HKW69_RS21540	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HKW69_RS21545	COG1924	4 iron, 4 sulfur cluster binding
HKW69_RS21560	COG0477	Major facilitator Superfamily
HKW69_RS21570	COG3366	ferrous iron transmembrane transporter activity
HKW69_RS21575	COG0700	Nucleoside recognition
HKW69_RS21580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKW69_RS21585	COG0583	DNA-binding transcription factor activity
HKW69_RS21600	COG2186	Transcriptional regulator
HKW69_RS21605	COG0246	Mannitol dehydrogenase
HKW69_RS21620	COG3539	Fimbrial protein
HKW69_RS21625	COG3539	Fimbrial protein
HKW69_RS21630	COG3539	Fimbrial protein
HKW69_RS21635	COG3188	usher protein
HKW69_RS21640	COG3121	Chaperone
HKW69_RS21645	COG3539	Fimbrial protein
HKW69_RS21650	COG3539	Fimbrial protein
HKW69_RS21655	COG4974	Belongs to the 'phage' integrase family
HKW69_RS21660	COG0582	viral genome integration into host DNA
HKW69_RS21665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HKW69_RS21730	COG2003	Belongs to the UPF0758 family
HKW69_RS21755	COG2378	regulation of single-species biofilm formation
HKW69_RS21760	COG3596	GTP binding
HKW69_RS21815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKW69_RS21855	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS21855	COG1454	alcohol dehydrogenase
HKW69_RS21865	COG1012	belongs to the aldehyde dehydrogenase family
HKW69_RS21865	COG1454	alcohol dehydrogenase
HKW69_RS21870	COG1882	Formate acetyltransferase
HKW69_RS21875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKW69_RS21885	COG4869	propanediol catabolic process
HKW69_RS21900	COG2076	Multidrug Resistance protein
HKW69_RS21910	COG0583	DNA-binding transcription factor activity
HKW69_RS21915	COG2610	gluconate transmembrane transporter activity
HKW69_RS22010	COG5002	protein histidine kinase activity
HKW69_RS22015	COG0745	RESPONSE REGULATOR receiver
HKW69_RS22020	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HKW69_RS22025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKW69_RS22080	COG3436	PFAM IS66 Orf2 family protein
HKW69_RS22085	COG4372	Transposase
HKW69_RS22090	COG1309	transcriptional regulator
HKW69_RS22100	COG1304	FMN binding
HKW69_RS22105	COG2259	Doxx family
HKW69_RS22235	COG2194	sulfuric ester hydrolase activity
HKW69_RS22240	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HKW69_RS22240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKW69_RS22245	COG0582	viral genome integration into host DNA
HKW69_RS22255	COG1064	alcohol dehydrogenase
HKW69_RS22260	COG3265	gluconokinase activity
HKW69_RS22265	COG1063	alcohol dehydrogenase
HKW69_RS22270	COG1028	Short-chain dehydrogenase reductase Sdr
HKW69_RS22275	COG2610	gluconate transmembrane transporter activity
HKW69_RS22280	COG1609	Transcriptional regulator
HKW69_RS22285	COG0433	COG0433 Predicted ATPase
HKW69_RS22290	COG0795	lipopolysaccharide-transporting ATPase activity
HKW69_RS22295	COG0795	lipopolysaccharide-transporting ATPase activity
HKW69_RS22305	COG2927	DNA polymerase III (CHI subunit)
HKW69_RS22310	COG0525	valine-tRNA ligase activity
HKW69_RS22320	COG0456	acetyltransferase
HKW69_RS22325	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HKW69_RS22330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKW69_RS22335	COG2731	YhcH YjgK YiaL family protein
HKW69_RS22345	COG0549	Belongs to the carbamate kinase family
HKW69_RS22350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKW69_RS22355	COG1288	antiporter activity
HKW69_RS22360	COG1438	arginine binding
HKW69_RS22380	COG0251	oxidation-reduction process
HKW69_RS22385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKW69_RS22395	COG1609	Transcriptional regulator
HKW69_RS22405	COG0366	Alpha amylase catalytic
HKW69_RS22410	COG1328	CTP reductase activity
HKW69_RS22415	COG0602	queuosine metabolic process
HKW69_RS22420	COG3783	Cytochrome b(562)
HKW69_RS22425	COG0312	modulator of DNA gyrase
HKW69_RS22435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKW69_RS22445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS22450	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS22455	COG1129	ABC transporter
HKW69_RS22460	COG1879	ABC-type sugar transport system periplasmic component
HKW69_RS22465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKW69_RS22470	COG2105	PFAM AIG2 family protein
HKW69_RS22475	COG2911	Protein conserved in bacteria
HKW69_RS22480	COG0729	surface antigen
HKW69_RS22490	COG1253	flavin adenine dinucleotide binding
HKW69_RS22500	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HKW69_RS22505	COG1218	3'(2'),5'-bisphosphate nucleotidase
HKW69_RS22510	COG0737	Belongs to the 5'-nucleotidase family
HKW69_RS22515	COG1733	regulation of RNA biosynthetic process
HKW69_RS22520	COG0702	epimerase
HKW69_RS22525	COG0697	spore germination
HKW69_RS22535	COG1113	amino acid transport
HKW69_RS22540	COG0545	Peptidyl-prolyl cis-trans isomerase
HKW69_RS22545	COG3061	Opacity-associated protein A
HKW69_RS22550	COG1309	transcriptional regulator
HKW69_RS22565	COG1024	Enoyl-CoA hydratase
HKW69_RS22570	COG4670	ketone body catabolic process
HKW69_RS22575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HKW69_RS22580	COG2271	Major facilitator Superfamily
HKW69_RS22605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKW69_RS22645	COG3414	Phosphotransferase system galactitol-specific IIB component
HKW69_RS22650	COG3037	sugar-specific permease SgaT UlaA
HKW69_RS22665	COG1073	alpha beta
HKW69_RS22670	COG3650	response to hydrogen peroxide
HKW69_RS22680	COG1960	acyl-CoA dehydrogenase activity
HKW69_RS22685	COG0754	glutathionylspermidine amidase activity
HKW69_RS22690	COG5463	Belongs to the UPF0441 family
HKW69_RS22695	COG3766	membrane
HKW69_RS22705	COG1842	Phage shock protein A
HKW69_RS22710	COG3789	protein conserved in bacteria
HKW69_RS22715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKW69_RS22720	COG0557	exoribonuclease II activity
HKW69_RS22735	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HKW69_RS22740	COG0330	HflC and HflK could
HKW69_RS22745	COG0330	HflC and HflK could
HKW69_RS22750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKW69_RS22770	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKW69_RS22775	COG0802	atpase or kinase
HKW69_RS22780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKW69_RS22780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKW69_RS22785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKW69_RS22825	COG3264	Mechanosensitive ion channel
HKW69_RS22825	COG1511	domain protein
HKW69_RS22830	COG0531	amino acid
HKW69_RS22840	COG1053	succinate dehydrogenase
HKW69_RS22845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKW69_RS22860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKW69_RS22865	COG3040	lipid binding
HKW69_RS22870	COG2076	Multidrug Resistance protein
HKW69_RS22875	COG5510	response to toxic substance
HKW69_RS22880	COG5510	response to toxic substance
HKW69_RS22890	COG1509	lysine 2,3-aminomutase activity
HKW69_RS22915	COG0531	amino acid
HKW69_RS22920	COG3030	protein affecting phage T7 exclusion by the F plasmid
HKW69_RS22925	COG1027	Aspartate ammonia-lyase
HKW69_RS22930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HKW69_RS22945	COG1309	transcriptional regulator
HKW69_RS22955	COG3710	Transcriptional regulator
HKW69_RS22960	COG0531	amino acid
HKW69_RS22965	COG1982	Orn Lys Arg decarboxylase major
HKW69_RS22970	COG3104	oligopeptide transport
HKW69_RS22975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKW69_RS22990	COG2388	GCN5-related N-acetyl-transferase
HKW69_RS22995	COG3592	Divergent 4Fe-4S mono-cluster
HKW69_RS23000	COG3290	protein histidine kinase activity
HKW69_RS23005	COG4565	transcriptional regulatory protein
HKW69_RS23010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HKW69_RS23015	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HKW69_RS23015	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HKW69_RS23020	COG3647	Membrane
HKW69_RS23025	COG1486	melibiose metabolic process
HKW69_RS23030	COG2169	Transcriptional regulator
HKW69_RS23035	COG1982	Orn Lys Arg decarboxylase major
HKW69_RS23040	COG2207	Transcriptional regulator
HKW69_RS23045	COG0531	amino acid
HKW69_RS23050	COG2194	sulfuric ester hydrolase activity
HKW69_RS23055	COG0745	RESPONSE REGULATOR receiver
HKW69_RS23060	COG0642	Histidine kinase
HKW69_RS23070	COG0477	Major facilitator Superfamily
HKW69_RS23085	COG2824	Alkylphosphonate utilization operon protein PhnA
HKW69_RS23090	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HKW69_RS23100	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HKW69_RS23105	COG3639	organic phosphonate transmembrane transporter activity
HKW69_RS23110	COG2188	Transcriptional regulator
HKW69_RS23115	COG3624	Phosphonate C-P lyase system protein PhnG
HKW69_RS23120	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HKW69_RS23125	COG3626	phosphonate metabolism
HKW69_RS23130	COG3627	carbon phosphorus lyase activity
HKW69_RS23135	COG4107	phosphonate C-P lyase system protein PhnK
HKW69_RS23140	COG4778	phosphonate C-P lyase system protein PhnL
HKW69_RS23145	COG3454	Phosphonate metabolism
HKW69_RS23155	COG0456	acetyltransferase
HKW69_RS23160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKW69_RS23170	COG0698	ribose 5-phosphate isomerase
HKW69_RS23175	COG1737	Transcriptional regulator
HKW69_RS23185	COG1129	ABC transporter
HKW69_RS23190	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS23195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKW69_RS23200	COG1940	carbohydrate kinase activity
HKW69_RS23205	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HKW69_RS23215	COG1566	PFAM secretion protein HlyD family protein
HKW69_RS23220	COG1289	transmembrane transporter activity
HKW69_RS23240	COG0601	transmembrane transport
HKW69_RS23250	COG0444	Belongs to the ABC transporter superfamily
HKW69_RS23255	COG4608	Belongs to the ABC transporter superfamily
HKW69_RS23260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HKW69_RS23270	COG1301	dicarboxylic acid transport
HKW69_RS23275	COG4235	cytochrome complex assembly
HKW69_RS23280	COG3088	subunit of a heme lyase
HKW69_RS23285	COG1138	Cytochrome C-type biogenesis protein
HKW69_RS23290	COG3301	Polysulphide reductase, NrfD
HKW69_RS23295	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS23300	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HKW69_RS23310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKW69_RS23315	COG3162	membrane
HKW69_RS23325	COG1346	cytolysis
HKW69_RS23330	COG1380	Effector of murein hydrolase LrgA
HKW69_RS23340	COG0025	NhaP-type Na H and K H
HKW69_RS23345	COG2252	PERMEase
HKW69_RS23350	COG0789	Transcriptional regulator
HKW69_RS23355	COG2207	Transcriptional regulator
HKW69_RS23360	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HKW69_RS23370	COG0629	single-stranded DNA binding
HKW69_RS23375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKW69_RS23380	COG2315	Protein conserved in bacteria
HKW69_RS23385	COG0432	Pfam Uncharacterised protein family UPF0047
HKW69_RS23390	COG3700	Belongs to the class B bacterial acid phosphatase family
HKW69_RS23400	COG2204	response regulator
HKW69_RS23405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HKW69_RS23410	COG0471	metal ion transport
HKW69_RS23415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKW69_RS23420	COG0045	succinate-CoA ligase (ADP-forming) activity
HKW69_RS23425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKW69_RS23435	COG0567	Dehydrogenase, E1 component
HKW69_RS23440	COG1448	Aminotransferase
HKW69_RS23450	COG3201	nicotinamide mononucleotide transporter
HKW69_RS23455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKW69_RS23465	COG0305	Participates in initiation and elongation during chromosome replication
HKW69_RS23470	COG0604	alcohol dehydrogenase
HKW69_RS23480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKW69_RS23485	COG0735	belongs to the Fur family
HKW69_RS23490	COG3237	CsbD-like
HKW69_RS23495	COG0534	Mate efflux family protein
HKW69_RS23505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HKW69_RS23540	COG2182	Extracellular solute-binding protein
HKW69_RS23545	COG1175	transmembrane transport
HKW69_RS23550	COG3833	ABC-type maltose transport systems, permease component
HKW69_RS23565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKW69_RS23590	COG0527	aspartate kinase activity
HKW69_RS23600	COG1187	pseudouridine synthase activity
HKW69_RS23645	COG1283	sodium-dependent phosphate transmembrane transporter activity
HKW69_RS23660	COG0646	methionine synthase
HKW69_RS23660	COG1410	methionine synthase
HKW69_RS23665	COG1414	Transcriptional regulator
HKW69_RS23675	COG2224	Isocitrate lyase
HKW69_RS23680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HKW69_RS23690	COG0456	acetyltransferase
HKW69_RS23725	COG0151	Belongs to the GarS family
HKW69_RS23730	COG2204	response regulator
HKW69_RS23735	COG4191	Histidine kinase
HKW69_RS23740	COG3678	ATP-independent chaperone mediated protein folding
HKW69_RS23755	COG3068	Protein conserved in bacteria
HKW69_RS23790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HKW69_RS23795	COG2104	thiamine diphosphate biosynthetic process
HKW69_RS23805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HKW69_RS23840	COG0250	Participates in transcription elongation, termination and antitermination
HKW69_RS23845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKW69_RS23880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HKW69_RS23880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HKW69_RS23885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HKW69_RS23935	COG0477	Major facilitator Superfamily
HKW69_RS23940	COG1473	amidohydrolase
HKW69_RS23950	COG0583	DNA-binding transcription factor activity
HKW69_RS23955	COG2271	Major facilitator Superfamily
HKW69_RS23960	COG4948	Mandelate Racemase Muconate Lactonizing
HKW69_RS23970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKW69_RS23975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKW69_RS23990	COG2194	sulfuric ester hydrolase activity
HKW69_RS23995	COG2207	Transcriptional regulator
HKW69_RS24000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS24005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKW69_RS24010	COG1882	Formate acetyltransferase
HKW69_RS24015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS24020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKW69_RS24025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKW69_RS24025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS24025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKW69_RS24030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKW69_RS24035	COG0371	Dehydrogenase
HKW69_RS24040	COG3738	Protein conserved in bacteria
HKW69_RS24045	COG0697	spore germination
HKW69_RS24055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKW69_RS24060	COG0737	Belongs to the 5'-nucleotidase family
HKW69_RS24070	COG0737	Belongs to the 5'-nucleotidase family
HKW69_RS24085	COG0460	homoserine dehydrogenase
HKW69_RS24085	COG0527	aspartate kinase activity
HKW69_RS24090	COG0626	cystathionine gamma-synthase activity
HKW69_RS24100	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HKW69_RS24110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKW69_RS24115	COG1609	Transcriptional regulator
HKW69_RS24120	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKW69_RS24135	COG1575	Belongs to the MenA family. Type 1 subfamily
HKW69_RS24150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKW69_RS24160	COG1494	fructose-1,6-bisphosphatase
HKW69_RS24185	COG3691	Protein conserved in bacteria
HKW69_RS24190	COG3152	Membrane
HKW69_RS24210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKW69_RS24225	COG3678	ATP-independent chaperone mediated protein folding
HKW69_RS24230	COG0745	RESPONSE REGULATOR receiver
HKW69_RS24235	COG2205	protein histidine kinase activity
HKW69_RS24240	COG2258	MOSC domain
HKW69_RS24250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKW69_RS24310	COG0437	4 iron, 4 sulfur cluster binding
HKW69_RS24315	COG2864	formate dehydrogenase
HKW69_RS24335	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HKW69_RS24345	COG0456	acetyltransferase
HKW69_RS24360	COG1011	Hydrolase
HKW69_RS24370	COG0477	Major facilitator Superfamily
HKW69_RS24380	COG1063	alcohol dehydrogenase
HKW69_RS24385	COG3684	Belongs to the aldolase LacD family
HKW69_RS24390	COG2084	Dehydrogenase
HKW69_RS24395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS24400	COG1349	DNA-binding transcription factor activity
HKW69_RS24405	COG2271	Major facilitator Superfamily
HKW69_RS24430	COG0697	spore germination
HKW69_RS24485	COG3300	MHYT domain
HKW69_RS24485	COG5001	Diguanylate cyclase
HKW69_RS24550	COG2188	Transcriptional regulator
HKW69_RS24560	COG0174	glutamine synthetase
HKW69_RS24565	COG3852	Histidine kinase
HKW69_RS24570	COG2204	response regulator
HKW69_RS24580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKW69_RS24595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKW69_RS24595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKW69_RS24600	COG0204	Acyl-transferase
HKW69_RS24605	COG5339	Protein conserved in bacteria
HKW69_RS24610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKW69_RS24615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKW69_RS24620	COG3084	Protein conserved in bacteria
HKW69_RS24625	COG0746	molybdenum cofactor guanylyltransferase activity
HKW69_RS24630	COG1763	Mo-molybdopterin cofactor biosynthetic process
HKW69_RS24660	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HKW69_RS24665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKW69_RS24670	COG1739	Uncharacterized protein family UPF0029
HKW69_RS24690	COG0543	2 iron, 2 sulfur cluster binding
HKW69_RS24695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HKW69_RS24710	COG0805	protein transport
HKW69_RS24720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKW69_RS24730	COG3165	ubiquinone biosynthetic process from chorismate
HKW69_RS24740	COG1322	Protein conserved in bacteria
HKW69_RS24745	COG1414	Transcriptional regulator
HKW69_RS24750	COG3734	2-keto-3-deoxy-galactonokinase
HKW69_RS24755	COG0800	Aldolase
HKW69_RS24775	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HKW69_RS24780	COG0412	Dienelactone hydrolase
HKW69_RS24785	COG1335	isochorismatase
HKW69_RS24795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HKW69_RS24800	COG1304	FMN binding
HKW69_RS24805	COG0549	Belongs to the carbamate kinase family
HKW69_RS24815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKW69_RS24820	COG0583	DNA-binding transcription factor activity
HKW69_RS24825	COG1737	Transcriptional regulator
HKW69_RS24830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKW69_RS24835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS24835	COG2190	(PTS) system
HKW69_RS24835	COG1263	PTS System
HKW69_RS24845	COG3157	Type VI secretion system effector, Hcp
HKW69_RS24860	COG0583	DNA-binding transcription factor activity
HKW69_RS24865	COG0697	spore germination
HKW69_RS24870	COG0561	phosphatase activity
HKW69_RS24875	COG2267	carboxylic ester hydrolase activity
HKW69_RS24880	COG1280	lysine exporter protein (LysE YggA)
HKW69_RS24885	COG1280	lysine exporter protein (LysE YggA)
HKW69_RS24890	COG0514	ATP-dependent DNA helicase (RecQ)
HKW69_RS24895	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HKW69_RS24900	COG2050	protein possibly involved in aromatic compounds catabolism
HKW69_RS24905	COG2962	Rard protein
HKW69_RS24920	COG0598	Magnesium transport protein CorA
HKW69_RS24925	COG3698	Phosphodiester glycosidase
HKW69_RS24930	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HKW69_RS24935	COG0210	DNA helicase
HKW69_RS24940	COG1011	Hydrolase
HKW69_RS24950	COG3159	Protein conserved in bacteria
HKW69_RS24960	COG5567	small periplasmic lipoprotein
HKW69_RS24975	COG3072	Adenylate cyclase
HKW69_RS24980	COG0181	hydroxymethylbilane synthase activity
HKW69_RS24985	COG1587	Uroporphyrinogen-III synthase
HKW69_RS24990	COG2959	enzyme of heme biosynthesis
HKW69_RS24995	COG3071	HemY protein
HKW69_RS25000	COG3119	arylsulfatase activity
HKW69_RS25005	COG0641	radical SAM
HKW69_RS25030	COG1113	amino acid transport
HKW69_RS25050	COG2244	polysaccharide biosynthetic process
HKW69_RS25055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HKW69_RS25060	COG0456	acetyltransferase
HKW69_RS25065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HKW69_RS25070	COG1088	dTDP-glucose 4,6-dehydratase activity
HKW69_RS25075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HKW69_RS25080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HKW69_RS25085	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HKW69_RS25090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKW69_RS25095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HKW69_RS25105	COG3118	belongs to the thioredoxin family
HKW69_RS25120	COG0210	DNA helicase
HKW69_RS25125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKW69_RS25135	COG0583	DNA-binding transcription factor activity
HKW69_RS25140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKW69_RS25150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKW69_RS25155	COG3978	acetolactate synthase activity
HKW69_RS25175	COG0606	chelatase, subunit chli
HKW69_RS25180	COG3085	chromosome segregation
HKW69_RS25220	COG2186	Transcriptional regulator
HKW69_RS25225	COG0477	Major facilitator Superfamily
HKW69_RS25230	COG1609	Transcriptional regulator
HKW69_RS25235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKW69_RS25240	COG1879	ABC-type sugar transport system periplasmic component
HKW69_RS25245	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKW69_RS25250	COG1129	ABC transporter
HKW69_RS25280	COG1522	sequence-specific DNA binding
HKW69_RS25285	COG0716	FMN binding
HKW69_RS25300	COG3312	ion transport
HKW69_RS25355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HKW69_RS25360	COG0573	inorganic phosphate transmembrane transporter activity
HKW69_RS25365	COG0581	inorganic phosphate transmembrane transporter activity
HKW69_RS25370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKW69_RS25375	COG0704	Plays a role in the regulation of phosphate uptake
HKW69_RS25380	COG3711	transcriptional antiterminator
HKW69_RS25385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKW69_RS25385	COG2190	(PTS) system
HKW69_RS25385	COG1263	PTS System
HKW69_RS25390	COG2723	6-phospho-beta-galactosidase activity
HKW69_RS25405	COG0363	glucosamine-6-phosphate deaminase activity
HKW69_RS25415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKW69_RS25420	COG2252	PERMEase
HKW69_RS25425	COG0431	NADPH-dependent FMN reductase
HKW69_RS25430	COG2091	lysine biosynthetic process via aminoadipic acid
HKW69_RS25435	COG0583	DNA-binding transcription factor activity
HKW69_RS25445	COG0814	amino acid
HKW69_RS25735	COG3344	reverse transcriptase
HKW69_RS25955	COG2805	Type II/IV secretion system protein
HKW69_RS26010	COG0741	lytic transglycosylase activity
HKW69_RS26025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKW69_RS26245	COG3344	reverse transcriptase
HKW69_RS26515	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HKW69_RS26695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKW69_RS26760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKW69_RS26805	COG3451	type IV secretory pathway VirB4
HKW69_RS26880	COG0330	HflC and HflK could