locus-tag	class	description
SH04_RS00040	COG0814	amino acid
SH04_RS00055	COG2091	lysine biosynthetic process via aminoadipic acid
SH04_RS00060	COG0431	NADPH-dependent FMN reductase
SH04_RS00065	COG2252	PERMEase
SH04_RS00070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH04_RS00080	COG3196	Protein conserved in bacteria
SH04_RS00085	COG0363	glucosamine-6-phosphate deaminase activity
SH04_RS00090	COG2382	esterase
SH04_RS00100	COG2723	6-phospho-beta-galactosidase activity
SH04_RS00105	COG1263	PTS System
SH04_RS00105	COG2190	(PTS) system
SH04_RS00105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS00110	COG3711	transcriptional antiterminator
SH04_RS00115	COG0704	Plays a role in the regulation of phosphate uptake
SH04_RS00120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SH04_RS00125	COG0581	inorganic phosphate transmembrane transporter activity
SH04_RS00130	COG0573	inorganic phosphate transmembrane transporter activity
SH04_RS00135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SH04_RS00140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SH04_RS00190	COG3312	ion transport
SH04_RS00205	COG0716	FMN binding
SH04_RS00210	COG1522	sequence-specific DNA binding
SH04_RS00240	COG1129	ABC transporter
SH04_RS00245	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH04_RS00250	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS00255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS00260	COG1609	Transcriptional regulator
SH04_RS00265	COG0477	Major facilitator Superfamily
SH04_RS00270	COG2186	Transcriptional regulator
SH04_RS00310	COG3085	chromosome segregation
SH04_RS00315	COG0606	chelatase, subunit chli
SH04_RS00330	COG3978	acetolactate synthase activity
SH04_RS00335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SH04_RS00345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SH04_RS00350	COG0583	DNA-binding transcription factor activity
SH04_RS00360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SH04_RS00370	COG0210	DNA helicase
SH04_RS00385	COG3118	belongs to the thioredoxin family
SH04_RS00395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SH04_RS00405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SH04_RS00410	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
SH04_RS00415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SH04_RS00420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SH04_RS00425	COG1088	dTDP-glucose 4,6-dehydratase activity
SH04_RS00430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SH04_RS00435	COG0456	acetyltransferase
SH04_RS00440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SH04_RS00445	COG2244	polysaccharide biosynthetic process
SH04_RS00465	COG1113	amino acid transport
SH04_RS00490	COG0641	radical SAM
SH04_RS00495	COG3119	arylsulfatase activity
SH04_RS00500	COG3071	HemY protein
SH04_RS00505	COG2959	enzyme of heme biosynthesis
SH04_RS00510	COG1587	Uroporphyrinogen-III synthase
SH04_RS00520	COG3072	Adenylate cyclase
SH04_RS00530	COG5567	small periplasmic lipoprotein
SH04_RS00540	COG3159	Protein conserved in bacteria
SH04_RS00550	COG1011	Hydrolase
SH04_RS00555	COG0210	DNA helicase
SH04_RS00560	COG3698	Phosphodiester glycosidase
SH04_RS00570	COG0598	Magnesium transport protein CorA
SH04_RS00585	COG2962	Rard protein
SH04_RS00590	COG2050	protein possibly involved in aromatic compounds catabolism
SH04_RS00595	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
SH04_RS00600	COG0514	ATP-dependent DNA helicase (RecQ)
SH04_RS00605	COG1280	lysine exporter protein (LysE YggA)
SH04_RS00610	COG1280	lysine exporter protein (LysE YggA)
SH04_RS00615	COG2267	carboxylic ester hydrolase activity
SH04_RS00620	COG0561	phosphatase activity
SH04_RS00625	COG0697	spore germination
SH04_RS00630	COG0583	DNA-binding transcription factor activity
SH04_RS00640	COG0412	Dienelactone hydrolase
SH04_RS00645	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SH04_RS00650	COG1322	Protein conserved in bacteria
SH04_RS00660	COG3165	ubiquinone biosynthetic process from chorismate
SH04_RS00670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SH04_RS00675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SH04_RS00680	COG0805	protein transport
SH04_RS00685	COG0084	hydrolase, TatD family'
SH04_RS00690	COG0250	Participates in transcription elongation, termination and antitermination
SH04_RS00695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SH04_RS00700	COG0543	2 iron, 2 sulfur cluster binding
SH04_RS00705	COG0183	Belongs to the thiolase family
SH04_RS00720	COG1739	Uncharacterized protein family UPF0029
SH04_RS00725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SH04_RS00730	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
SH04_RS00760	COG1763	Mo-molybdopterin cofactor biosynthetic process
SH04_RS00765	COG0746	molybdenum cofactor guanylyltransferase activity
SH04_RS00770	COG3084	Protein conserved in bacteria
SH04_RS00775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SH04_RS00780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SH04_RS00785	COG5339	Protein conserved in bacteria
SH04_RS00790	COG0204	Acyl-transferase
SH04_RS00800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH04_RS00800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SH04_RS00815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SH04_RS00825	COG2204	response regulator
SH04_RS00830	COG3852	Histidine kinase
SH04_RS00835	COG0174	glutamine synthetase
SH04_RS00845	COG1217	gtp-binding protein TYPA
SH04_RS00850	COG2188	Transcriptional regulator
SH04_RS00855	COG1082	Xylose isomerase domain protein TIM barrel
SH04_RS00860	COG2271	Major facilitator Superfamily
SH04_RS00865	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SH04_RS00870	COG2211	Major facilitator Superfamily
SH04_RS00875	COG2211	Major facilitator Superfamily
SH04_RS00880	COG1501	Belongs to the glycosyl hydrolase 31 family
SH04_RS00885	COG2017	converts alpha-aldose to the beta-anomer
SH04_RS00890	COG2942	2-epimerase
SH04_RS00895	COG3684	Belongs to the aldolase LacD family
SH04_RS00900	COG2084	Dehydrogenase
SH04_RS00905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS00910	COG1349	DNA-binding transcription factor activity
SH04_RS00915	COG1011	Hydrolase
SH04_RS00930	COG0456	acetyltransferase
SH04_RS00935	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SH04_RS00940	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SH04_RS00955	COG2864	formate dehydrogenase
SH04_RS00960	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS00965	COG3383	formate dehydrogenase (NAD+) activity
SH04_RS00965	COG0243	molybdopterin cofactor binding
SH04_RS00970	COG0243	molybdopterin cofactor binding
SH04_RS00970	COG3383	formate dehydrogenase (NAD+) activity
SH04_RS00985	COG3711	transcriptional antiterminator
SH04_RS00985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS00990	COG1363	Peptidase, m42
SH04_RS00995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS00995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS01000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS01045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SH04_RS01060	COG2258	MOSC domain
SH04_RS01065	COG2205	protein histidine kinase activity
SH04_RS01070	COG0745	RESPONSE REGULATOR receiver
SH04_RS01075	COG3678	ATP-independent chaperone mediated protein folding
SH04_RS01090	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SH04_RS01110	COG3152	Membrane
SH04_RS01115	COG3691	Protein conserved in bacteria
SH04_RS01120	COG0589	response to stress
SH04_RS01125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SH04_RS01130	COG1494	fructose-1,6-bisphosphatase
SH04_RS01140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SH04_RS01155	COG1575	Belongs to the MenA family. Type 1 subfamily
SH04_RS01170	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SH04_RS01175	COG1609	Transcriptional regulator
SH04_RS01180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SH04_RS01190	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
SH04_RS01205	COG0460	homoserine dehydrogenase
SH04_RS01205	COG0527	aspartate kinase activity
SH04_RS01215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SH04_RS01225	COG0697	spore germination
SH04_RS01230	COG3738	Protein conserved in bacteria
SH04_RS01240	COG0371	Dehydrogenase
SH04_RS01245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SH04_RS01250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS01250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS01250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH04_RS01255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS01260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS01265	COG1882	Formate acetyltransferase
SH04_RS01270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SH04_RS01275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS01280	COG2207	Transcriptional regulator
SH04_RS01285	COG2194	sulfuric ester hydrolase activity
SH04_RS01305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SH04_RS01320	COG0583	DNA-binding transcription factor activity
SH04_RS01345	COG4206	TonB-dependent receptor
SH04_RS01375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SH04_RS01380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SH04_RS01380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SH04_RS01420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SH04_RS01425	COG0250	Participates in transcription elongation, termination and antitermination
SH04_RS01465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SH04_RS01475	COG2104	thiamine diphosphate biosynthetic process
SH04_RS01480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SH04_RS01515	COG3068	Protein conserved in bacteria
SH04_RS01530	COG3678	ATP-independent chaperone mediated protein folding
SH04_RS01535	COG4191	Histidine kinase
SH04_RS01540	COG2204	response regulator
SH04_RS01545	COG0151	Belongs to the GarS family
SH04_RS01590	COG0456	acetyltransferase
SH04_RS01600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SH04_RS01605	COG2224	Isocitrate lyase
SH04_RS01620	COG1414	Transcriptional regulator
SH04_RS01625	COG0646	methionine synthase
SH04_RS01625	COG1410	methionine synthase
SH04_RS01630	COG1283	sodium-dependent phosphate transmembrane transporter activity
SH04_RS01640	COG1187	pseudouridine synthase activity
SH04_RS01650	COG0527	aspartate kinase activity
SH04_RS01685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SH04_RS01705	COG0477	Major facilitator Superfamily
SH04_RS01705	COG2814	Major facilitator Superfamily
SH04_RS01710	COG3833	ABC-type maltose transport systems, permease component
SH04_RS01715	COG1175	transmembrane transport
SH04_RS01720	COG2182	Extracellular solute-binding protein
SH04_RS01730	COG3842	ATPase activity
SH04_RS01750	COG1357	PFAM Pentapeptide repeats (8 copies)
SH04_RS01770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SH04_RS01780	COG0534	Mate efflux family protein
SH04_RS01785	COG3237	CsbD-like
SH04_RS01790	COG0735	belongs to the Fur family
SH04_RS01805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SH04_RS01815	COG0604	alcohol dehydrogenase
SH04_RS01820	COG0305	Participates in initiation and elongation during chromosome replication
SH04_RS01825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SH04_RS01830	COG1448	Aminotransferase
SH04_RS01840	COG3700	Belongs to the class B bacterial acid phosphatase family
SH04_RS01845	COG0432	Pfam Uncharacterised protein family UPF0047
SH04_RS01850	COG2315	Protein conserved in bacteria
SH04_RS01855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SH04_RS01860	COG0629	single-stranded DNA binding
SH04_RS01870	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SH04_RS01875	COG2207	Transcriptional regulator
SH04_RS01880	COG0789	Transcriptional regulator
SH04_RS01885	COG2252	PERMEase
SH04_RS01890	COG0025	NhaP-type Na H and K H
SH04_RS01895	COG1357	PFAM Pentapeptide repeats (8 copies)
SH04_RS01905	COG3162	membrane
SH04_RS01910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SH04_RS01920	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SH04_RS01925	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS01930	COG3301	Polysulphide reductase, NrfD
SH04_RS01935	COG1138	Cytochrome C-type biogenesis protein
SH04_RS01940	COG3088	subunit of a heme lyase
SH04_RS01945	COG4235	cytochrome complex assembly
SH04_RS01950	COG1301	dicarboxylic acid transport
SH04_RS01955	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SH04_RS01960	COG3383	formate dehydrogenase (NAD+) activity
SH04_RS01965	COG3383	formate dehydrogenase (NAD+) activity
SH04_RS01970	COG1538	Outer membrane efflux protein
SH04_RS01975	COG1289	transmembrane transporter activity
SH04_RS01980	COG1566	PFAM secretion protein HlyD family protein
SH04_RS01990	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SH04_RS01995	COG1940	carbohydrate kinase activity
SH04_RS02000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SH04_RS02005	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH04_RS02010	COG1129	ABC transporter
SH04_RS02015	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS02020	COG1737	Transcriptional regulator
SH04_RS02025	COG0698	ribose 5-phosphate isomerase
SH04_RS02035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SH04_RS02040	COG0456	acetyltransferase
SH04_RS02045	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SH04_RS02050	COG3454	Phosphonate metabolism
SH04_RS02055	COG4778	phosphonate C-P lyase system protein PhnL
SH04_RS02060	COG4107	phosphonate C-P lyase system protein PhnK
SH04_RS02065	COG3627	carbon phosphorus lyase activity
SH04_RS02070	COG3626	phosphonate metabolism
SH04_RS02075	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
SH04_RS02080	COG3624	Phosphonate C-P lyase system protein PhnG
SH04_RS02085	COG2188	Transcriptional regulator
SH04_RS02095	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SH04_RS02100	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SH04_RS02105	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SH04_RS02110	COG2824	Alkylphosphonate utilization operon protein PhnA
SH04_RS02115	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SH04_RS02125	COG0477	Major facilitator Superfamily
SH04_RS02135	COG0642	Histidine kinase
SH04_RS02140	COG0745	RESPONSE REGULATOR receiver
SH04_RS02145	COG2194	sulfuric ester hydrolase activity
SH04_RS02150	COG0531	amino acid
SH04_RS02155	COG2207	Transcriptional regulator
SH04_RS02160	COG1982	Orn Lys Arg decarboxylase major
SH04_RS02165	COG2169	Transcriptional regulator
SH04_RS02175	COG1486	melibiose metabolic process
SH04_RS02180	COG2211	Major facilitator Superfamily
SH04_RS02185	COG3647	Membrane
SH04_RS02190	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SH04_RS02190	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SH04_RS02195	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SH04_RS02205	COG4565	transcriptional regulatory protein
SH04_RS02210	COG3290	protein histidine kinase activity
SH04_RS02215	COG3592	Divergent 4Fe-4S mono-cluster
SH04_RS02220	COG2388	GCN5-related N-acetyl-transferase
SH04_RS02235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SH04_RS02240	COG3104	oligopeptide transport
SH04_RS02245	COG1982	Orn Lys Arg decarboxylase major
SH04_RS02250	COG0531	amino acid
SH04_RS02255	COG3710	Transcriptional regulator
SH04_RS02265	COG1309	transcriptional regulator
SH04_RS02270	COG4232	protein-disulfide reductase activity
SH04_RS02280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SH04_RS02285	COG1027	Aspartate ammonia-lyase
SH04_RS02290	COG3030	protein affecting phage T7 exclusion by the F plasmid
SH04_RS02295	COG0531	amino acid
SH04_RS02320	COG1509	lysine 2,3-aminomutase activity
SH04_RS02330	COG5510	response to toxic substance
SH04_RS02335	COG5510	response to toxic substance
SH04_RS02340	COG2076	Multidrug Resistance protein
SH04_RS02345	COG3040	lipid binding
SH04_RS02350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH04_RS02365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SH04_RS02370	COG1053	succinate dehydrogenase
SH04_RS02380	COG0531	amino acid
SH04_RS02395	COG3264	Mechanosensitive ion channel
SH04_RS02395	COG1511	domain protein
SH04_RS02430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SH04_RS02435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SH04_RS02435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SH04_RS02440	COG0802	atpase or kinase
SH04_RS02445	COG0860	N-Acetylmuramoyl-L-alanine amidase
SH04_RS02465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SH04_RS02470	COG0330	HflC and HflK could
SH04_RS02475	COG0330	HflC and HflK could
SH04_RS02480	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
SH04_RS02495	COG0557	exoribonuclease II activity
SH04_RS02500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH04_RS02505	COG3789	protein conserved in bacteria
SH04_RS02510	COG1842	Phage shock protein A
SH04_RS02520	COG3766	membrane
SH04_RS02525	COG5463	Belongs to the UPF0441 family
SH04_RS02530	COG0754	glutathionylspermidine amidase activity
SH04_RS02535	COG1960	acyl-CoA dehydrogenase activity
SH04_RS02545	COG3650	response to hydrogen peroxide
SH04_RS02550	COG1073	alpha beta
SH04_RS02565	COG3037	sugar-specific permease SgaT UlaA
SH04_RS02570	COG3414	Phosphotransferase system galactitol-specific IIB component
SH04_RS02575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS02615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SH04_RS02630	COG1309	transcriptional regulator
SH04_RS02635	COG3061	Opacity-associated protein A
SH04_RS02640	COG0545	Peptidyl-prolyl cis-trans isomerase
SH04_RS02645	COG1113	amino acid transport
SH04_RS02655	COG0697	spore germination
SH04_RS02660	COG0702	epimerase
SH04_RS02665	COG1733	regulation of RNA biosynthetic process
SH04_RS02670	COG0737	Belongs to the 5'-nucleotidase family
SH04_RS02675	COG1218	3'(2'),5'-bisphosphate nucleotidase
SH04_RS02685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
SH04_RS02695	COG1253	flavin adenine dinucleotide binding
SH04_RS02710	COG0729	surface antigen
SH04_RS02715	COG2911	Protein conserved in bacteria
SH04_RS02720	COG2105	PFAM AIG2 family protein
SH04_RS02725	COG2336	PFAM SpoVT AbrB
SH04_RS02730	COG2337	Toxic component of a toxin-antitoxin (TA) module
SH04_RS02735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SH04_RS02740	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS02745	COG1129	ABC transporter
SH04_RS02750	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH04_RS02755	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH04_RS02765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SH04_RS02775	COG0312	modulator of DNA gyrase
SH04_RS02780	COG3783	Cytochrome b(562)
SH04_RS02785	COG0602	queuosine metabolic process
SH04_RS02790	COG1328	CTP reductase activity
SH04_RS02795	COG0366	Alpha amylase catalytic
SH04_RS02800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS02800	COG1263	PTS System
SH04_RS02805	COG1609	Transcriptional regulator
SH04_RS02810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SH04_RS02815	COG0251	oxidation-reduction process
SH04_RS02840	COG0251	oxidation-reduction process
SH04_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS02850	COG1309	transcriptional regulator
SH04_RS02855	COG2731	YhcH YjgK YiaL family protein
SH04_RS02865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SH04_RS02870	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
SH04_RS02875	COG0456	acetyltransferase
SH04_RS02880	COG4269	membrane
SH04_RS02885	COG0525	valine-tRNA ligase activity
SH04_RS02890	COG2927	DNA polymerase III (CHI subunit)
SH04_RS02900	COG0795	lipopolysaccharide-transporting ATPase activity
SH04_RS02905	COG0795	lipopolysaccharide-transporting ATPase activity
SH04_RS02910	COG0433	COG0433 Predicted ATPase
SH04_RS02915	COG1609	Transcriptional regulator
SH04_RS02920	COG2610	gluconate transmembrane transporter activity
SH04_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS02930	COG1063	alcohol dehydrogenase
SH04_RS02935	COG3265	gluconokinase activity
SH04_RS02940	COG1064	alcohol dehydrogenase
SH04_RS02950	COG0582	viral genome integration into host DNA
SH04_RS02995	COG3385	transposase activity
SH04_RS03000	COG2814	Major facilitator Superfamily
SH04_RS03005	COG0673	inositol 2-dehydrogenase activity
SH04_RS03025	COG2826	transposase and inactivated derivatives, IS30 family
SH04_RS03040	COG2085	NADP oxidoreductase coenzyme F420-dependent
SH04_RS03045	COG1120	ATPase activity
SH04_RS03050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH04_RS03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH04_RS03060	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SH04_RS03065	COG4772	TonB-dependent receptor
SH04_RS03070	COG3712	iron ion homeostasis
SH04_RS03075	COG1595	DNA-templated transcription, initiation
SH04_RS03095	COG2390	Transcriptional regulator
SH04_RS03105	COG2610	gluconate transmembrane transporter activity
SH04_RS03110	COG0129	dihydroxy-acid dehydratase activity
SH04_RS03115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SH04_RS03120	COG1414	Transcriptional regulator
SH04_RS03125	COG1349	DNA-binding transcription factor activity
SH04_RS03130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SH04_RS03135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS03140	COG0434	BtpA family
SH04_RS03145	COG3775	system Galactitol-specific IIC component
SH04_RS03150	COG3414	Phosphotransferase system galactitol-specific IIB component
SH04_RS03155	COG1363	Peptidase, m42
SH04_RS03160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SH04_RS03165	COG3153	acetyltransferase
SH04_RS03185	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SH04_RS03185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH04_RS03195	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
SH04_RS03200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SH04_RS03215	COG0582	viral genome integration into host DNA
SH04_RS03220	COG4974	Belongs to the 'phage' integrase family
SH04_RS03230	COG3539	Fimbrial protein
SH04_RS03235	COG3539	Fimbrial protein
SH04_RS03240	COG3121	Chaperone
SH04_RS03245	COG3188	usher protein
SH04_RS03250	COG3539	Fimbrial protein
SH04_RS03255	COG3539	Fimbrial protein
SH04_RS03260	COG3539	Fimbrial protein
SH04_RS03265	COG2610	gluconate transmembrane transporter activity
SH04_RS03280	COG0246	Mannitol dehydrogenase
SH04_RS03290	COG2186	Transcriptional regulator
SH04_RS03320	COG0583	DNA-binding transcription factor activity
SH04_RS03325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SH04_RS03330	COG0700	Nucleoside recognition
SH04_RS03335	COG3366	ferrous iron transmembrane transporter activity
SH04_RS03345	COG0477	Major facilitator Superfamily
SH04_RS03350	COG3204	pilus organization
SH04_RS03360	COG1924	4 iron, 4 sulfur cluster binding
SH04_RS03365	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SH04_RS03370	COG2733	membrane
SH04_RS03375	COG2814	Major facilitator Superfamily
SH04_RS03385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SH04_RS03390	COG5457	Domain of unknown function (DUF1127)
SH04_RS03395	COG1196	nuclear chromosome segregation
SH04_RS03405	COG4268	DNA restriction-modification system
SH04_RS03410	COG1401	restriction endodeoxyribonuclease activity
SH04_RS03420	COG0732	type I restriction modification DNA specificity domain
SH04_RS03425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SH04_RS03430	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SH04_RS03445	COG1715	Restriction endonuclease
SH04_RS03450	COG0523	cobalamin synthesis protein
SH04_RS03455	COG2879	small protein
SH04_RS03460	COG1966	Carbon starvation protein
SH04_RS03470	COG0840	transmembrane signaling receptor activity
SH04_RS03475	COG2271	Major facilitator Superfamily
SH04_RS03480	COG1802	Transcriptional regulator
SH04_RS03485	COG1063	alcohol dehydrogenase
SH04_RS03500	COG1484	DNA-dependent DNA replication
SH04_RS03515	COG2966	Psort location CytoplasmicMembrane, score
SH04_RS03520	COG2197	response regulator
SH04_RS03525	COG2197	response regulator
SH04_RS03530	COG4114	ferric iron reductase
SH04_RS03560	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
SH04_RS03565	COG0456	acetyltransferase
SH04_RS03570	COG1011	Hydrolase
SH04_RS03580	COG2823	Periplasmic or secreted lipoprotein
SH04_RS03590	COG4667	esterase of the alpha-beta hydrolase superfamily
SH04_RS03595	COG0084	hydrolase, TatD family'
SH04_RS03600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SH04_RS03605	COG1328	CTP reductase activity
SH04_RS03635	COG3550	peptidyl-serine autophosphorylation
SH04_RS03645	COG3726	membrane protein affecting hemolysin expression
SH04_RS03650	COG0560	Phosphoserine phosphatase
SH04_RS03655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SH04_RS03660	COG3172	ATPase kinase involved in NAD metabolism
SH04_RS03660	COG1056	cytidyltransferase-related domain
SH04_RS03670	COG0488	(ABC) transporter
SH04_RS03675	COG0741	lytic transglycosylase activity
SH04_RS03695	COG2207	Transcriptional regulator
SH04_RS03695	COG3708	Transcriptional regulator
SH04_RS03700	COG3045	CreA protein
SH04_RS03705	COG0745	RESPONSE REGULATOR receiver
SH04_RS03710	COG2205	protein histidine kinase activity
SH04_RS03715	COG4452	Inner membrane protein CreD
SH04_RS03720	COG0745	RESPONSE REGULATOR receiver
SH04_RS03730	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SH04_RS03740	COG0460	homoserine dehydrogenase
SH04_RS03740	COG0527	aspartate kinase activity
SH04_RS03750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SH04_RS03770	COG1115	amino acid carrier protein
SH04_RS03775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SH04_RS03780	COG0521	Mo-molybdopterin cofactor biosynthetic process
SH04_RS03785	COG1584	GPR1 FUN34 yaaH family protein
SH04_RS03790	COG4735	regulation of single-species biofilm formation
SH04_RS03810	COG3385	transposase activity
SH04_RS03820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SH04_RS03825	COG0583	DNA-binding transcription factor activity
SH04_RS03845	COG0196	riboflavin kinase activity
SH04_RS03860	COG1047	Peptidyl-prolyl cis-trans
SH04_RS03890	COG0505	Belongs to the CarA family
SH04_RS03895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SH04_RS03950	COG0644	oxidoreductase
SH04_RS03955	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SH04_RS03960	COG2271	Major facilitator Superfamily
SH04_RS03975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SH04_RS04000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SH04_RS04005	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SH04_RS04010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SH04_RS04020	COG0564	pseudouridine synthase activity
SH04_RS04030	COG0417	DNA replication proofreading
SH04_RS04035	COG0235	Class ii aldolase
SH04_RS04040	COG2160	L-arabinose isomerase activity
SH04_RS04045	COG1069	ribulokinase activity
SH04_RS04050	COG4977	sequence-specific DNA binding
SH04_RS04055	COG0586	Pfam SNARE associated Golgi protein
SH04_RS04060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SH04_RS04065	COG1178	ABC-type Fe3 transport system permease component
SH04_RS04070	COG4143	(ABC) transporter
SH04_RS04075	COG4533	DNA binding
SH04_RS04085	COG2814	Major facilitator Superfamily
SH04_RS04100	COG0473	3-isopropylmalate dehydrogenase activity
SH04_RS04115	COG0583	DNA-binding transcription factor activity
SH04_RS04120	COG0028	Belongs to the TPP enzyme family
SH04_RS04125	COG0440	acetolactate synthase activity
SH04_RS04135	COG1609	Transcriptional regulator
SH04_RS04140	COG2001	Belongs to the MraZ family
SH04_RS04150	COG3116	cell division
SH04_RS04155	COG0768	penicillin binding
SH04_RS04160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SH04_RS04165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SH04_RS04175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SH04_RS04180	COG0772	Belongs to the SEDS family
SH04_RS04195	COG1181	Belongs to the D-alanine--D-alanine ligase family
SH04_RS04200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SH04_RS04205	COG0849	cell division
SH04_RS04210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SH04_RS04230	COG0494	nUDIX hydrolase
SH04_RS04250	COG0237	dephospho-CoA kinase activity
SH04_RS04260	COG1459	type II secretion system
SH04_RS04265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SH04_RS04270	COG4969	Belongs to the N-Me-Phe pilin family
SH04_RS04280	COG0157	Belongs to the NadC ModD family
SH04_RS04285	COG3023	N-Acetylmuramoyl-L-alanine amidase
SH04_RS04290	COG3725	Membrane protein required for beta-lactamase induction
SH04_RS04295	COG1113	amino acid transport
SH04_RS04300	COG2186	Transcriptional regulator
SH04_RS04305	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SH04_RS04310	COG0508	dehydrogenase complex catalyzes the overall conversion of
SH04_RS04315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH04_RS04320	COG3064	Membrane
SH04_RS04325	COG1049	propionate catabolic process, 2-methylcitrate cycle
SH04_RS04350	COG2132	Multicopper oxidase
SH04_RS04355	COG4993	Dehydrogenase
SH04_RS04360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SH04_RS04365	COG0288	reversible hydration of carbon dioxide
SH04_RS04370	COG1131	(ABC) transporter
SH04_RS04375	COG0842	Transport permease protein
SH04_RS04380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS04385	COG0726	polysaccharide deacetylase
SH04_RS04395	COG5464	transposase or invertase
SH04_RS04410	COG3539	Fimbrial protein
SH04_RS04415	COG3539	Fimbrial protein
SH04_RS04420	COG3539	Fimbrial protein
SH04_RS04425	COG3539	Fimbrial protein
SH04_RS04430	COG3188	usher protein
SH04_RS04435	COG3121	Chaperone
SH04_RS04440	COG3539	Fimbrial protein
SH04_RS04445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SH04_RS04450	COG0617	tRNA 3'-terminal CCA addition
SH04_RS04460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SH04_RS04470	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SH04_RS04475	COG1643	Atp-dependent helicase
SH04_RS04485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SH04_RS04490	COG4774	siderophore transport
SH04_RS04495	COG1120	ATPase activity
SH04_RS04500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SH04_RS04505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH04_RS04525	COG2860	membrane
SH04_RS04530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SH04_RS04545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH04_RS04550	COG3835	regulator
SH04_RS04560	COG1408	metallophosphoesterase
SH04_RS04575	COG0024	Methionine aminopeptidase
SH04_RS04600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SH04_RS04605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SH04_RS04610	COG0575	Belongs to the CDS family
SH04_RS04615	COG0750	zinc metalloprotease
SH04_RS04625	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
SH04_RS04630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SH04_RS04655	COG0587	DNA-directed DNA polymerase activity
SH04_RS04665	COG1982	Orn Lys Arg decarboxylase major
SH04_RS04670	COG0346	lactoylglutathione lyase activity
SH04_RS04675	COG0037	tRNA processing
SH04_RS04680	COG4568	rho-dependent transcription termination
SH04_RS04690	COG4681	YaeQ
SH04_RS04695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SH04_RS04700	COG3015	lipoprotein NlpE involved in copper resistance
SH04_RS04705	COG0791	NLP P60 protein
SH04_RS04715	COG1720	tRNA m6t6A37 methyltransferase activity
SH04_RS04725	COG1464	Belongs to the NlpA lipoprotein family
SH04_RS04730	COG2011	ABC-type metal ion transport system permease component
SH04_RS04735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SH04_RS04740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SH04_RS04775	COG0656	L-ascorbic acid biosynthetic process
SH04_RS04780	COG0583	DNA-binding transcription factor activity
SH04_RS04790	COG2226	methyltransferase
SH04_RS04795	COG0741	lytic transglycosylase activity
SH04_RS04795	COG1388	LysM domain
SH04_RS04805	COG2226	methyltransferase
SH04_RS04815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH04_RS04835	COG4104	PAAR repeat-containing protein
SH04_RS04840	COG5433	transposase activity
SH04_RS04845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SH04_RS04855	COG1960	acyl-CoA dehydrogenase activity
SH04_RS04865	COG0121	glutamine amidotransferase
SH04_RS04870	COG3034	peptidoglycan biosynthetic process
SH04_RS04875	COG3041	Addiction module toxin RelE StbE family
SH04_RS04880	COG3077	Addiction module antitoxin, RelB DinJ family
SH04_RS04885	COG0791	NLP P60 protein
SH04_RS04890	COG1943	Transposase
SH04_RS04910	COG2161	toxin-antitoxin pair type II binding
SH04_RS04920	COG0454	-acetyltransferase
SH04_RS04925	COG1690	Belongs to the RtcB family
SH04_RS04930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SH04_RS04935	COG2195	Cleaves the N-terminal amino acid of tripeptides
SH04_RS04955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SH04_RS04985	COG2003	Belongs to the UPF0758 family
SH04_RS05005	COG2378	regulation of single-species biofilm formation
SH04_RS05020	COG3596	GTP binding
SH04_RS05025	COG0583	DNA-binding transcription factor activity
SH04_RS05030	COG2963	transposase activity
SH04_RS05035	COG2826	transposase and inactivated derivatives, IS30 family
SH04_RS05040	COG2801	Transposase and inactivated derivatives
SH04_RS05055	COG3344	reverse transcriptase
SH04_RS05065	COG0833	amino acid
SH04_RS05070	COG2040	homocysteine
SH04_RS05075	COG3842	ATPase activity
SH04_RS05080	COG1178	ABC-type Fe3 transport system permease component
SH04_RS05085	COG1662	PFAM IS1 transposase
SH04_RS05090	COG1662	PFAM IS1 transposase
SH04_RS05090	COG3677	Transposase
SH04_RS05095	COG2963	transposase activity
SH04_RS05105	COG3415	Transposase
SH04_RS05105	COG2801	Transposase and inactivated derivatives
SH04_RS05110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SH04_RS05115	COG0129	dihydroxy-acid dehydratase activity
SH04_RS05120	COG2211	Major facilitator Superfamily
SH04_RS05125	COG3507	Belongs to the glycosyl hydrolase 43 family
SH04_RS05130	COG1414	Transcriptional regulator
SH04_RS05135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SH04_RS05140	COG1662	PFAM IS1 transposase
SH04_RS05145	COG1061	Type III restriction enzyme res subunit
SH04_RS05155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SH04_RS05175	COG0582	viral genome integration into host DNA
SH04_RS05185	COG0583	DNA-binding transcription factor activity
SH04_RS05190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SH04_RS05195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SH04_RS05200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SH04_RS05205	COG2080	2 iron, 2 sulfur cluster binding
SH04_RS05210	COG3477	response to acidic pH
SH04_RS05215	COG0727	PFAM Uncharacterised protein family (UPF0153)
SH04_RS05220	COG3121	Chaperone
SH04_RS05230	COG3188	usher protein
SH04_RS05270	COG1388	LysM domain
SH04_RS05280	COG2801	Transposase and inactivated derivatives
SH04_RS05285	COG3708	Transcriptional regulator
SH04_RS05285	COG2207	Transcriptional regulator
SH04_RS05290	COG3059	membrane
SH04_RS05300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH04_RS05305	COG2207	Transcriptional regulator
SH04_RS05310	COG0247	lactate metabolic process
SH04_RS05315	COG1139	Iron-sulfur cluster binding protein
SH04_RS05320	COG1556	Lactate utilization protein
SH04_RS05350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SH04_RS05360	COG2771	luxR family
SH04_RS05360	COG2200	EAL domain
SH04_RS05365	COG0583	DNA-binding transcription factor activity
SH04_RS05375	COG0666	response to abiotic stimulus
SH04_RS05385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SH04_RS05390	COG1304	FMN binding
SH04_RS05400	COG0549	Belongs to the carbamate kinase family
SH04_RS05405	COG0402	S-adenosylhomocysteine deaminase activity
SH04_RS05410	COG1064	alcohol dehydrogenase
SH04_RS05425	COG1280	lysine exporter protein (LysE YggA)
SH04_RS05435	COG3829	transcription factor binding
SH04_RS05440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SH04_RS05445	COG0372	Belongs to the citrate synthase family
SH04_RS05455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SH04_RS05460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SH04_RS05465	COG0402	S-adenosylhomocysteine deaminase activity
SH04_RS05470	COG0583	DNA-binding transcription factor activity
SH04_RS05475	COG0288	reversible hydration of carbon dioxide
SH04_RS05485	COG2807	transmembrane transport
SH04_RS05490	COG0110	maltose O-acetyltransferase activity
SH04_RS05495	COG2223	nitrite transmembrane transporter activity
SH04_RS05500	COG3250	beta-galactosidase activity
SH04_RS05505	COG1609	Transcriptional regulator
SH04_RS05510	COG1414	Transcriptional regulator
SH04_RS05530	COG3971	2-oxopent-4-enoate hydratase activity
SH04_RS05545	COG2814	Major facilitator Superfamily
SH04_RS05550	COG3122	Protein conserved in bacteria
SH04_RS05560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SH04_RS05590	COG1215	transferase activity, transferring glycosyl groups
SH04_RS05595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SH04_RS05600	COG4521	taurine ABC transporter
SH04_RS05610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SH04_RS05615	COG2175	clavaminate synthase activity
SH04_RS05620	COG0113	porphobilinogen synthase activity
SH04_RS05635	COG2801	Transposase and inactivated derivatives
SH04_RS05645	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS05650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH04_RS05655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH04_RS05665	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
SH04_RS05685	COG1181	Belongs to the D-alanine--D-alanine ligase family
SH04_RS05700	COG1785	Belongs to the alkaline phosphatase family
SH04_RS05710	COG3706	GGDEF domain
SH04_RS05715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SH04_RS05740	COG4126	flavin adenine dinucleotide binding
SH04_RS05760	COG1940	carbohydrate kinase activity
SH04_RS05765	COG2814	Major facilitator Superfamily
SH04_RS05770	COG0419	ATPase involved in DNA repair
SH04_RS05775	COG0420	3'-5' exonuclease activity
SH04_RS05780	COG0745	RESPONSE REGULATOR receiver
SH04_RS05785	COG5002	protein histidine kinase activity
SH04_RS05790	COG1114	Component of the transport system for branched-chain amino acids
SH04_RS05795	COG1113	amino acid transport
SH04_RS05800	COG0366	Alpha amylase catalytic
SH04_RS05820	COG1862	Preprotein translocase
SH04_RS05825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SH04_RS05830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SH04_RS05835	COG1403	HNH endonuclease
SH04_RS05845	COG3248	Nucleoside-binding outer membrane protein
SH04_RS05850	COG4238	major outer membrane lipoprotein
SH04_RS05860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SH04_RS05860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SH04_RS05875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SH04_RS05880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SH04_RS05885	COG0667	Aldo Keto reductase
SH04_RS05895	COG0142	geranyltranstransferase activity
SH04_RS05910	COG0693	protein deglycase activity
SH04_RS05915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SH04_RS05925	COG2814	Major facilitator Superfamily
SH04_RS05935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SH04_RS05940	COG1845	cytochrome c oxidase, subunit III
SH04_RS05945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SH04_RS05950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SH04_RS05955	COG2223	nitrite transmembrane transporter activity
SH04_RS05960	COG3056	Lipoprotein
SH04_RS05965	COG0271	Belongs to the BolA IbaG family
SH04_RS05990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SH04_RS05995	COG0776	regulation of translation
SH04_RS06000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SH04_RS06005	COG1555	photosystem II stabilization
SH04_RS06010	COG0824	Thioesterase
SH04_RS06020	COG4533	DNA binding
SH04_RS06030	COG1522	sequence-specific DNA binding
SH04_RS06035	COG1132	(ABC) transporter
SH04_RS06040	COG1132	(ABC) transporter
SH04_RS06045	COG0347	Belongs to the P(II) protein family
SH04_RS06050	COG0004	ammonium transporteR
SH04_RS06055	COG1946	Acyl-CoA thioesterase
SH04_RS06060	COG3126	Type III secretion system lipoprotein chaperone (YscW)
SH04_RS06065	COG3695	enzyme binding
SH04_RS06070	COG5507	3-demethylubiquinone-9 3-methyltransferase
SH04_RS06075	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SH04_RS06085	COG0110	maltose O-acetyltransferase activity
SH04_RS06100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SH04_RS06105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS06110	COG1309	transcriptional regulator
SH04_RS06115	COG3264	Mechanosensitive ion channel
SH04_RS06115	COG1196	nuclear chromosome segregation
SH04_RS06130	COG3923	Primosomal replication protein n
SH04_RS06135	COG2832	Protein of unknown function (DUF454)
SH04_RS06145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SH04_RS06180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS06185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SH04_RS06185	COG4651	solute:proton antiporter activity
SH04_RS06190	COG2223	nitrite transmembrane transporter activity
SH04_RS06195	COG0737	Belongs to the 5'-nucleotidase family
SH04_RS06200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SH04_RS06205	COG3735	TraB family
SH04_RS06210	COG3093	addiction module antidote protein HigA
SH04_RS06215	COG2217	Heavy metal translocating P-type atpase
SH04_RS06220	COG2066	Belongs to the glutaminase family
SH04_RS06225	COG0531	amino acid
SH04_RS06230	COG0789	Transcriptional regulator
SH04_RS06235	COG1585	Membrane protein implicated in regulation of membrane protease activity
SH04_RS06240	COG0330	HflC and HflK could
SH04_RS06245	COG4619	ABC transporter
SH04_RS06250	COG0390	transport system, permease component
SH04_RS06255	COG3118	belongs to the thioredoxin family
SH04_RS06260	COG0300	oxidoreductase activity
SH04_RS06265	COG2755	lipolytic protein G-D-S-L family
SH04_RS06270	COG4181	ATPase activity
SH04_RS06275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SH04_RS06280	COG3209	COG3209 Rhs family protein
SH04_RS06290	COG3209	COG3209 Rhs family protein
SH04_RS06300	COG2801	Transposase and inactivated derivatives
SH04_RS06310	COG0583	DNA-binding transcription factor activity
SH04_RS06320	COG1414	Transcriptional regulator
SH04_RS06325	COG3960	tartronate-semialdehyde synthase activity
SH04_RS06330	COG3622	Belongs to the hyi family
SH04_RS06335	COG2084	Dehydrogenase
SH04_RS06340	COG1953	Uracil, thiamine, allantoin
SH04_RS06350	COG2233	PERMEase
SH04_RS06355	COG1929	Belongs to the glycerate kinase type-1 family
SH04_RS06360	COG3257	ureidoglycine aminohydrolase activity
SH04_RS06365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SH04_RS06370	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SH04_RS06375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SH04_RS06380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SH04_RS06390	COG0549	Belongs to the carbamate kinase family
SH04_RS06395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SH04_RS06400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SH04_RS06410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SH04_RS06420	COG1988	membrane-bound metal-dependent
SH04_RS06425	COG2501	S4 domain
SH04_RS06435	COG3539	Fimbrial protein
SH04_RS06440	COG3121	Chaperone
SH04_RS06445	COG3188	usher protein
SH04_RS06450	COG3539	Fimbrial protein
SH04_RS06455	COG3539	Fimbrial protein
SH04_RS06460	COG2197	response regulator
SH04_RS06470	COG0582	viral genome integration into host DNA
SH04_RS06495	COG2801	Transposase and inactivated derivatives
SH04_RS06505	COG2076	Multidrug Resistance protein
SH04_RS06515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SH04_RS06520	COG1881	PFAM PEBP family protein
SH04_RS06525	COG2207	Transcriptional regulator
SH04_RS06580	COG3772	lysozyme
SH04_RS06600	COG5562	phage envelope protein
SH04_RS06620	COG4220	transposase activity
SH04_RS06630	COG0500	methyltransferase
SH04_RS06640	COG2207	Transcriptional regulator
SH04_RS06645	COG4571	Outer membrane protease
SH04_RS06655	COG2207	Transcriptional regulator
SH04_RS06665	COG4783	chaperone-mediated protein folding
SH04_RS06670	COG1215	transferase activity, transferring glycosyl groups
SH04_RS06675	COG5002	protein histidine kinase activity
SH04_RS06680	COG0745	RESPONSE REGULATOR receiver
SH04_RS06685	COG1538	Outer membrane efflux protein
SH04_RS06690	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS06695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS06700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SH04_RS06705	COG1113	amino acid transport
SH04_RS06710	COG0668	transmembrane transport
SH04_RS06715	COG0778	Nitroreductase
SH04_RS06720	COG2315	Protein conserved in bacteria
SH04_RS06745	COG3385	transposase activity
SH04_RS06750	COG2977	Belongs to the P-Pant transferase superfamily
SH04_RS06755	COG4771	TonB-dependent receptor
SH04_RS06760	COG2382	esterase
SH04_RS06765	COG3251	PFAM MbtH domain protein
SH04_RS06770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SH04_RS06770	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SH04_RS06775	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
SH04_RS06780	COG1120	ATPase activity
SH04_RS06785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH04_RS06790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SH04_RS06800	COG4592	Periplasmic binding protein
SH04_RS06805	COG1169	isochorismate synthase
SH04_RS06810	COG1021	2,3-dihydroxybenzoate-AMP ligase
SH04_RS06815	COG3433	isochorismatase activity
SH04_RS06815	COG1535	isochorismatase
SH04_RS06820	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS06825	COG2050	protein possibly involved in aromatic compounds catabolism
SH04_RS06830	COG1966	Carbon starvation protein
SH04_RS06835	COG2879	small protein
SH04_RS06840	COG0371	Dehydrogenase
SH04_RS06845	COG0436	Aminotransferase
SH04_RS06850	COG1475	DNA binding
SH04_RS06855	COG3969	phosphoadenosine phosphosulfate
SH04_RS06860	COG0583	DNA-binding transcription factor activity
SH04_RS06865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SH04_RS06870	COG0450	alkyl hydroperoxide reductase
SH04_RS06875	COG3634	alkyl hydroperoxide reductase activity
SH04_RS06880	COG0589	response to stress
SH04_RS06885	COG1063	alcohol dehydrogenase
SH04_RS06895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SH04_RS06900	COG3719	Belongs to the RNase T2 family
SH04_RS06905	COG0471	metal ion transport
SH04_RS06920	COG3051	citrate lyase alpha subunit
SH04_RS06925	COG2301	Belongs to the HpcH HpaI aldolase family
SH04_RS06935	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SH04_RS06940	COG3290	protein histidine kinase activity
SH04_RS06945	COG4565	transcriptional regulatory protein
SH04_RS06950	COG3069	C4-dicarboxylate transmembrane transporter activity
SH04_RS06975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SH04_RS06985	COG0583	DNA-binding transcription factor activity
SH04_RS07005	COG1686	Belongs to the peptidase S11 family
SH04_RS07010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SH04_RS07015	COG0772	Belongs to the SEDS family
SH04_RS07020	COG0768	penicillin binding
SH04_RS07030	COG0799	negative regulation of ribosome biogenesis
SH04_RS07035	COG0406	alpha-ribazole phosphatase activity
SH04_RS07045	COG1466	dna polymerase III delta subunit
SH04_RS07060	COG2888	peptidyl-tyrosine sulfation
SH04_RS07065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SH04_RS07075	COG2214	Heat shock protein DnaJ domain protein
SH04_RS07080	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SH04_RS07090	COG2214	Heat shock protein DnaJ domain protein
SH04_RS07095	COG0443	Heat shock 70 kDa protein
SH04_RS07105	COG1126	abc transporter atp-binding protein
SH04_RS07110	COG0765	amino acid transport
SH04_RS07115	COG0765	amino acid transport
SH04_RS07120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS07130	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SH04_RS07135	COG4535	Mg2 and Co2 transporter CorC
SH04_RS07145	COG1702	phosphate starvation-inducible protein PhoH
SH04_RS07155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SH04_RS07195	COG0367	asparagine synthase
SH04_RS07200	COG0647	UMP catabolic process
SH04_RS07205	COG1940	carbohydrate kinase activity
SH04_RS07205	COG1846	Transcriptional regulator
SH04_RS07210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SH04_RS07220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS07220	COG1263	PTS System
SH04_RS07220	COG2190	(PTS) system
SH04_RS07240	COG0735	belongs to the Fur family
SH04_RS07255	COG0716	FMN binding
SH04_RS07265	COG0596	Alpha beta hydrolase
SH04_RS07270	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
SH04_RS07275	COG0033	Phosphoglucomutase
SH04_RS07295	COG0531	amino acid
SH04_RS07300	COG1982	Orn Lys Arg decarboxylase major
SH04_RS07310	COG0745	RESPONSE REGULATOR receiver
SH04_RS07315	COG2205	protein histidine kinase activity
SH04_RS07345	COG3209	COG3209 Rhs family protein
SH04_RS07355	COG3209	COG3209 Rhs family protein
SH04_RS07365	COG5433	transposase activity
SH04_RS07375	COG5433	transposase activity
SH04_RS07380	COG3272	Protein of unknown function (DUF1722)
SH04_RS07385	COG0415	Belongs to the DNA photolyase family
SH04_RS07390	COG3104	oligopeptide transport
SH04_RS07395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SH04_RS07400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SH04_RS07405	COG1984	allophanate hydrolase subunit 2
SH04_RS07420	COG3180	Ammonia monooxygenase
SH04_RS07425	COG3539	Fimbrial protein
SH04_RS07430	COG3121	Chaperone
SH04_RS07435	COG3188	usher protein
SH04_RS07440	COG3539	Fimbrial protein
SH04_RS07445	COG0372	Belongs to the citrate synthase family
SH04_RS07455	COG2009	succinate dehydrogenase
SH04_RS07460	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SH04_RS07465	COG1053	succinate dehydrogenase
SH04_RS07470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SH04_RS07480	COG0567	Dehydrogenase, E1 component
SH04_RS07485	COG0508	dehydrogenase complex catalyzes the overall conversion of
SH04_RS07495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SH04_RS07500	COG2188	Transcriptional regulator
SH04_RS07505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS07505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS07505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS07510	COG0383	alpha-mannosidase activity
SH04_RS07520	COG1271	oxidase subunit
SH04_RS07525	COG1294	oxidase, subunit
SH04_RS07530	COG4890	Cyd operon protein YbgT
SH04_RS07535	COG3790	cyd operon protein YbgE
SH04_RS07540	COG0824	Thioesterase
SH04_RS07545	COG0811	peptide transport
SH04_RS07550	COG0848	biopolymer transport protein
SH04_RS07555	COG3064	Membrane
SH04_RS07565	COG2885	chlorophyll binding
SH04_RS07570	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
SH04_RS07615	COG3201	nicotinamide mononucleotide transporter
SH04_RS07620	COG1230	cation diffusion facilitator family transporter
SH04_RS07635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SH04_RS07645	COG2017	converts alpha-aldose to the beta-anomer
SH04_RS07655	COG1085	galactose-1-phosphate uridylyltransferase
SH04_RS07660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SH04_RS07665	COG1119	ATPase activity
SH04_RS07670	COG3585	molybdate ion transport
SH04_RS07670	COG2005	Transcriptional regulator
SH04_RS07680	COG0725	ABC transporter, periplasmic molybdate-binding protein
SH04_RS07685	COG4149	molybdate abc transporter
SH04_RS07690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SH04_RS07695	COG0561	phosphatase activity
SH04_RS07705	COG0583	DNA-binding transcription factor activity
SH04_RS07710	COG2828	Protein conserved in bacteria
SH04_RS07715	COG0471	metal ion transport
SH04_RS07720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SH04_RS07725	COG4677	pectinesterase activity
SH04_RS07730	COG1881	PFAM PEBP family protein
SH04_RS07735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SH04_RS07750	COG2226	methyltransferase
SH04_RS07755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SH04_RS07765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SH04_RS07780	COG0521	Mo-molybdopterin cofactor biosynthetic process
SH04_RS07790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SH04_RS07795	COG0314	molybdopterin synthase activity
SH04_RS07800	COG0670	Belongs to the BI1 family
SH04_RS07805	COG0670	Belongs to the BI1 family
SH04_RS07810	COG0392	lysyltransferase activity
SH04_RS07815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH04_RS07820	COG3568	Endonuclease Exonuclease Phosphatase
SH04_RS07830	COG0842	Transport permease protein
SH04_RS07835	COG0842	Transport permease protein
SH04_RS07840	COG1131	(ABC) transporter
SH04_RS07850	COG1309	transcriptional regulator
SH04_RS07855	COG0513	Belongs to the DEAD box helicase family
SH04_RS07860	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
SH04_RS07865	COG1199	ATP-dependent helicase activity
SH04_RS07870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SH04_RS07875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SH04_RS07885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SH04_RS07895	COG4774	siderophore transport
SH04_RS07910	COG0668	transmembrane transport
SH04_RS07915	COG1126	abc transporter atp-binding protein
SH04_RS07920	COG0765	amino acid transport
SH04_RS07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS07940	COG5006	permease, DMT superfamily
SH04_RS07945	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SH04_RS07950	COG2194	sulfuric ester hydrolase activity
SH04_RS07960	COG1321	iron dependent repressor
SH04_RS07965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SH04_RS07970	COG1376	ErfK ybiS ycfS ynhG family protein
SH04_RS07975	COG0488	(ABC) transporter
SH04_RS07985	COG0561	phosphatase activity
SH04_RS07990	COG1882	Formate acetyltransferase
SH04_RS07995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SH04_RS08000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SH04_RS08005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SH04_RS08010	COG0303	'Molybdopterin
SH04_RS08015	COG1446	asparaginase
SH04_RS08020	COG4172	Belongs to the ABC transporter superfamily
SH04_RS08025	COG0747	negative chemotaxis
SH04_RS08035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH04_RS08040	COG2200	EAL domain
SH04_RS08045	COG2199	diguanylate cyclase activity
SH04_RS08060	COG2133	pyrroloquinoline quinone binding
SH04_RS08065	COG0625	glutathione transferase activity
SH04_RS08070	COG1686	Belongs to the peptidase S11 family
SH04_RS08075	COG1349	DNA-binding transcription factor activity
SH04_RS08080	COG0671	phosphoesterase, PA-phosphatase related
SH04_RS08085	COG2814	Major facilitator Superfamily
SH04_RS08095	COG0561	phosphatase activity
SH04_RS08100	COG0738	Major facilitator superfamily
SH04_RS08105	COG3226	Transcriptional regulator
SH04_RS08120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SH04_RS08130	COG0778	Nitroreductase
SH04_RS08150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SH04_RS08155	COG3842	ATPase activity
SH04_RS08160	COG1176	ABC-type spermidine putrescine transport system, permease component I
SH04_RS08165	COG1177	transmembrane transport
SH04_RS08180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS08185	COG4160	amino acid transport
SH04_RS08190	COG4215	(ABC) transporter
SH04_RS08195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS08200	COG1126	abc transporter atp-binding protein
SH04_RS08215	COG3023	N-Acetylmuramoyl-L-alanine amidase
SH04_RS08220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SH04_RS08225	COG0702	epimerase
SH04_RS08230	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SH04_RS08235	COG0028	Belongs to the TPP enzyme family
SH04_RS08240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SH04_RS08250	COG2431	L-lysine efflux transmembrane transporter activity
SH04_RS08265	COG3593	DNA synthesis involved in DNA repair
SH04_RS08270	COG2990	Protein conserved in bacteria
SH04_RS08275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS08280	COG0577	efflux transmembrane transporter activity
SH04_RS08280	COG1136	(ABC) transporter
SH04_RS08285	COG1278	Cold shock
SH04_RS08295	COG0542	response to heat
SH04_RS08315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SH04_RS08320	COG4988	ABC transporter
SH04_RS08325	COG0492	ferredoxin-NADP+ reductase activity
SH04_RS08330	COG1522	sequence-specific DNA binding
SH04_RS08335	COG1178	ABC-type Fe3 transport system permease component
SH04_RS08335	COG1674	ftsk spoiiie
SH04_RS08345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SH04_RS08355	COG0243	molybdopterin cofactor binding
SH04_RS08360	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS08365	COG3302	dmso reductase anchor subunit
SH04_RS08370	COG1335	isochorismatase
SH04_RS08380	COG0531	amino acid
SH04_RS08385	COG0583	DNA-binding transcription factor activity
SH04_RS08390	COG2249	NAD(P)H dehydrogenase (quinone) activity
SH04_RS08395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SH04_RS08400	COG1882	Formate acetyltransferase
SH04_RS08405	COG2116	formate transmembrane transporter activity
SH04_RS08410	COG1944	ATP diphosphatase activity
SH04_RS08415	COG2323	membrane
SH04_RS08430	COG0501	Belongs to the peptidase M48B family
SH04_RS08440	COG0539	negative regulation of cytoplasmic translation
SH04_RS08450	COG2333	competence protein COMEC
SH04_RS08450	COG0658	competence protein
SH04_RS08455	COG1132	(ABC) transporter
SH04_RS08465	COG3214	Protein conserved in bacteria
SH04_RS08480	COG3173	Aminoglycoside phosphotransferase
SH04_RS08485	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SH04_RS08490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SH04_RS08500	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
SH04_RS08510	COG2989	Protein conserved in bacteria
SH04_RS08515	COG3108	Peptidase M15
SH04_RS08520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SH04_RS08525	COG1448	Aminotransferase
SH04_RS08550	COG0308	aminopeptidase N
SH04_RS08555	COG1116	anion transmembrane transporter activity
SH04_RS08560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SH04_RS08570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SH04_RS08575	COG0431	NADPH-dependent FMN reductase
SH04_RS08580	COG3539	Fimbrial protein
SH04_RS08585	COG3121	Chaperone
SH04_RS08590	COG3188	usher protein
SH04_RS08595	COG3539	Fimbrial protein
SH04_RS08600	COG3539	Fimbrial protein
SH04_RS08605	COG3539	Fimbrial protein
SH04_RS08610	COG3121	Chaperone
SH04_RS08625	COG3217	Mosc domain protein beta barrel domain protein
SH04_RS08625	COG0633	Ferredoxin
SH04_RS08635	COG0488	(ABC) transporter
SH04_RS08640	COG2995	paraquat-inducible protein a
SH04_RS08645	COG3008	intermembrane lipid transfer
SH04_RS08645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SH04_RS08650	COG3009	Protein conserved in bacteria
SH04_RS08655	COG3130	regulation of translation
SH04_RS08665	COG1067	ATP-dependent peptidase activity
SH04_RS08675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SH04_RS08675	COG2885	chlorophyll binding
SH04_RS08690	COG3070	regulator of competence-specific genes
SH04_RS08695	COG1289	transmembrane transporter activity
SH04_RS08700	COG3304	Inner membrane component domain
SH04_RS08705	COG0210	DNA helicase
SH04_RS08725	COG1832	CoA-binding protein
SH04_RS08740	COG1254	Belongs to the acylphosphatase family
SH04_RS08745	COG2920	part of a sulfur-relay system
SH04_RS08750	COG0670	Belongs to the BI1 family
SH04_RS08760	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SH04_RS08765	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SH04_RS08770	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SH04_RS08775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SH04_RS08780	COG1999	signal sequence binding
SH04_RS08785	COG1773	rubredoxin
SH04_RS08790	COG1271	oxidase subunit
SH04_RS08795	COG1294	oxidase, subunit
SH04_RS08810	COG0489	protein tyrosine kinase activity
SH04_RS08810	COG3206	protein involved in exopolysaccharide biosynthesis
SH04_RS08815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH04_RS08820	COG1596	polysaccharide export
SH04_RS08825	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SH04_RS08850	COG1662	PFAM IS1 transposase
SH04_RS08855	COG1278	Cold shock
SH04_RS08860	COG1278	Cold shock
SH04_RS08875	COG0348	domain, Protein
SH04_RS08880	COG2198	Histidine kinase
SH04_RS08880	COG0784	Response regulator, receiver
SH04_RS08880	COG2205	protein histidine kinase activity
SH04_RS08885	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS08890	COG0745	RESPONSE REGULATOR receiver
SH04_RS08895	COG3005	denitrification pathway
SH04_RS08900	COG0243	molybdopterin cofactor binding
SH04_RS08945	COG3729	General stress protein
SH04_RS08950	COG2233	PERMEase
SH04_RS08985	COG1309	transcriptional regulator
SH04_RS08990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SH04_RS08990	COG0506	proline dehydrogenase activity
SH04_RS08990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SH04_RS09000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SH04_RS09015	COG2822	iron ion transport
SH04_RS09020	COG2837	iron assimilation
SH04_RS09030	COG1702	phosphate starvation-inducible protein PhoH
SH04_RS09035	COG3658	cytochrome
SH04_RS09040	COG1215	transferase activity, transferring glycosyl groups
SH04_RS09045	COG1649	PFAM Uncharacterised BCR, COG1649
SH04_RS09045	COG0726	polysaccharide deacetylase
SH04_RS09050	COG0457	Tetratricopeptide repeat
SH04_RS09055	COG3706	GGDEF domain
SH04_RS09060	COG2801	Transposase and inactivated derivatives
SH04_RS09100	COG3381	protein complex oligomerization
SH04_RS09110	COG1462	curli production assembly transport component CsgG
SH04_RS09125	COG2197	response regulator
SH04_RS09155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SH04_RS09160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH04_RS09185	COG2943	transferase activity, transferring hexosyl groups
SH04_RS09190	COG5645	(Lipo)protein
SH04_RS09210	COG1560	Kdo2-lipid A biosynthetic process
SH04_RS09220	COG2353	YceI-like domain
SH04_RS09225	COG3038	cytochrome b561
SH04_RS09260	COG2999	glutathione oxidoreductase activity
SH04_RS09270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH04_RS09280	COG0673	inositol 2-dehydrogenase activity
SH04_RS09285	COG0728	peptidoglycan biosynthetic process
SH04_RS09290	COG3418	PFAM FlgN family protein
SH04_RS09295	COG2747	anti-sigma28 factor FlgM
SH04_RS09300	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SH04_RS09305	COG1815	bacterial-type flagellum-dependent cell motility
SH04_RS09310	COG1558	bacterial-type flagellum-dependent cell motility
SH04_RS09315	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SH04_RS09320	COG1749	Flagellar hook protein flgE
SH04_RS09325	COG4787	bacterial-type flagellum-dependent cell motility
SH04_RS09330	COG4786	Flagellar basal body rod
SH04_RS09345	COG1705	Flagellar rod assembly protein muramidase FlgJ
SH04_RS09345	COG3951	Flagellar rod assembly protein muramidase FlgJ
SH04_RS09350	COG1256	bacterial-type flagellum assembly
SH04_RS09355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SH04_RS09360	COG1530	ribonuclease E activity
SH04_RS09370	COG0564	pseudouridine synthase activity
SH04_RS09375	COG0424	maF-like protein
SH04_RS09380	COG1399	metal-binding, possibly nucleic acid-binding protein
SH04_RS09400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SH04_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS09415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SH04_RS09420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SH04_RS09425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SH04_RS09435	COG0470	DNA polymerase III
SH04_RS09440	COG0084	hydrolase, TatD family'
SH04_RS09445	COG1263	PTS System
SH04_RS09445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS09450	COG4773	Receptor
SH04_RS09455	COG0537	adenosine 5'-monophosphoramidase activity
SH04_RS09460	COG5633	Lipoprotein
SH04_RS09465	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
SH04_RS09485	COG1252	NADH dehydrogenase
SH04_RS09490	COG3134	Outer membrane lipoprotein
SH04_RS09495	COG1309	transcriptional regulator
SH04_RS09505	COG1376	ErfK ybiS ycfS ynhG family protein
SH04_RS09505	COG1388	LysM domain
SH04_RS09510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SH04_RS09515	COG4763	Acyl-transferase
SH04_RS09520	COG4591	ABC-type transport system involved in lipoprotein release permease component
SH04_RS09525	COG1136	(ABC) transporter
SH04_RS09530	COG4591	ABC-type transport system involved in lipoprotein release permease component
SH04_RS09540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SH04_RS09545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SH04_RS09555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SH04_RS09560	COG1177	transmembrane transport
SH04_RS09570	COG3842	ATPase activity
SH04_RS09585	COG2850	peptidyl-arginine hydroxylation
SH04_RS09590	COG2205	protein histidine kinase activity
SH04_RS09595	COG0745	RESPONSE REGULATOR receiver
SH04_RS09600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SH04_RS09620	COG1187	pseudouridine synthase activity
SH04_RS09625	COG0538	isocitrate dehydrogenase activity
SH04_RS09640	COG5562	phage envelope protein
SH04_RS09645	COG0789	Transcriptional regulator
SH04_RS09650	COG2200	EAL domain
SH04_RS09675	COG2200	EAL domain
SH04_RS09725	COG2894	cell division
SH04_RS09755	COG0179	Fumarylacetoacetate (FAA) hydrolase
SH04_RS09770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SH04_RS09775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SH04_RS09780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SH04_RS09795	COG2719	SpoVR family
SH04_RS09805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SH04_RS09815	COG1619	proteins homologs of microcin C7 resistance protein MccF
SH04_RS09825	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SH04_RS09830	COG2261	transglycosylase associated protein
SH04_RS09845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH04_RS09845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS09845	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SH04_RS09850	COG1461	Dihydroxyacetone kinase
SH04_RS09855	COG2376	Dihydroxyacetone kinase
SH04_RS09860	COG3284	Transcriptional regulator
SH04_RS09865	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS09875	COG0012	GTP binding
SH04_RS09890	COG0659	secondary active sulfate transmembrane transporter activity
SH04_RS09895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SH04_RS09920	COG2890	protein-(glutamine-N5) methyltransferase activity
SH04_RS09925	COG3094	Invasion gene expression up-regulator, SirB
SH04_RS09930	COG2912	Transglutaminase-like superfamily
SH04_RS09950	COG0387	Pfam Sodium calcium exchanger
SH04_RS09955	COG4572	Cation transport regulator
SH04_RS09960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SH04_RS09965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SH04_RS09970	COG4932	domain protein
SH04_RS09975	COG2197	response regulator
SH04_RS09980	COG3850	Histidine kinase
SH04_RS09990	COG2223	nitrite transmembrane transporter activity
SH04_RS09995	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SH04_RS10000	COG1140	nitrate reductase beta subunit
SH04_RS10005	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SH04_RS10010	COG2181	nitrate reductase activity
SH04_RS10030	COG0788	formyltetrahydrofolate deformylase activity
SH04_RS10040	COG1752	Esterase of the alpha-beta hydrolase superfamily
SH04_RS10045	COG0745	RESPONSE REGULATOR receiver
SH04_RS10050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SH04_RS10060	COG1435	thymidine kinase activity
SH04_RS10075	COG1454	alcohol dehydrogenase
SH04_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS10080	COG2095	MarC family integral membrane protein
SH04_RS10085	COG4166	transmembrane transport
SH04_RS10090	COG0601	transmembrane transport
SH04_RS10095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH04_RS10100	COG0444	Belongs to the ABC transporter superfamily
SH04_RS10105	COG4608	Belongs to the ABC transporter superfamily
SH04_RS10125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SH04_RS10130	COG2350	Protein conserved in bacteria
SH04_RS10135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SH04_RS10140	COG1607	acyl-coa hydrolase
SH04_RS10155	COG3047	cAMP biosynthetic process
SH04_RS10160	COG3685	Protein conserved in bacteria
SH04_RS10165	COG3685	Protein conserved in bacteria
SH04_RS10170	COG3729	General stress protein
SH04_RS10185	COG0134	indole-3-glycerol-phosphate synthase activity
SH04_RS10185	COG0135	phosphoribosylanthranilate isomerase activity
SH04_RS10190	COG0512	Glutamine amidotransferase of anthranilate synthase
SH04_RS10190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SH04_RS10195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SH04_RS10200	COG0613	PHP domain protein
SH04_RS10205	COG0009	L-threonylcarbamoyladenylate synthase
SH04_RS10210	COG4907	membrane protein (DUF2207)
SH04_RS10215	COG1187	pseudouridine synthase activity
SH04_RS10220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SH04_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS10235	COG0616	signal peptide processing
SH04_RS10250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SH04_RS10255	COG0583	DNA-binding transcription factor activity
SH04_RS10275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SH04_RS10285	COG0671	phosphoesterase, PA-phosphatase related
SH04_RS10290	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
SH04_RS10295	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SH04_RS10305	COG0023	Translation Initiation Factor
SH04_RS10315	COG1349	DNA-binding transcription factor activity
SH04_RS10325	COG5001	Diguanylate cyclase
SH04_RS10340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SH04_RS10340	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SH04_RS10345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SH04_RS10350	COG2852	Protein conserved in bacteria
SH04_RS10355	COG4172	Belongs to the ABC transporter superfamily
SH04_RS10360	COG4172	Belongs to the ABC transporter superfamily
SH04_RS10365	COG4171	peptide transport system, permease
SH04_RS10370	COG4168	peptide transport system, permease
SH04_RS10375	COG4166	transmembrane transport
SH04_RS10390	COG0531	amino acid
SH04_RS10395	COG0174	glutamine synthetase
SH04_RS10400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SH04_RS10405	COG1917	Cupin 2, conserved barrel domain protein
SH04_RS10405	COG1396	sequence-specific DNA binding
SH04_RS10410	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS10415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SH04_RS10420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SH04_RS10425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SH04_RS10430	COG1842	Phage shock protein A
SH04_RS10440	COG1983	PspC domain protein
SH04_RS10450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SH04_RS10455	COG0366	Alpha amylase catalytic
SH04_RS10460	COG1653	transport
SH04_RS10465	COG1175	transmembrane transport
SH04_RS10470	COG0395	ABC-type sugar transport system, permease component
SH04_RS10475	COG1063	alcohol dehydrogenase
SH04_RS10480	COG1082	Xylose isomerase domain protein TIM barrel
SH04_RS10485	COG0673	inositol 2-dehydrogenase activity
SH04_RS10490	COG1554	hydrolase, family 65, central catalytic
SH04_RS10495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH04_RS10510	COG1609	Transcriptional regulator
SH04_RS10515	COG3106	COG3106 Predicted ATPase
SH04_RS10525	COG3283	Transcriptional regulator of aromatic amino acids metabolism
SH04_RS10530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SH04_RS10535	COG4948	Mandelate Racemase Muconate Lactonizing
SH04_RS10540	COG2866	Carboxypeptidase
SH04_RS10545	COG0702	epimerase
SH04_RS10550	COG1073	alpha beta
SH04_RS10555	COG0583	DNA-binding transcription factor activity
SH04_RS10565	COG4166	transmembrane transport
SH04_RS10570	COG0668	transmembrane transport
SH04_RS10580	COG3182	Iron-regulated membrane protein
SH04_RS10585	COG0589	response to stress
SH04_RS10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH04_RS10595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SH04_RS10600	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SH04_RS10610	COG1473	amidohydrolase
SH04_RS10615	COG1473	amidohydrolase
SH04_RS10620	COG0583	DNA-binding transcription factor activity
SH04_RS10630	COG2840	Smr protein MutS2
SH04_RS10635	COG3706	GGDEF domain
SH04_RS10650	COG0513	Belongs to the DEAD box helicase family
SH04_RS10660	COG0582	viral genome integration into host DNA
SH04_RS10680	COG3723	Recombinational DNA repair protein, rece pathway
SH04_RS10685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH04_RS10715	COG4197	protein conserved in bacteria, prophage-related
SH04_RS10725	COG3756	Protein conserved in bacteria
SH04_RS10730	COG1484	DNA-dependent DNA replication
SH04_RS10735	COG1846	Transcriptional regulator
SH04_RS10745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SH04_RS10750	COG1475	DNA binding
SH04_RS10765	COG1196	nuclear chromosome segregation
SH04_RS10775	COG3039	Transposase
SH04_RS10795	COG5301	cellulose 1,4-beta-cellobiosidase activity
SH04_RS10800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SH04_RS10805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SH04_RS10815	COG0589	response to stress
SH04_RS10820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SH04_RS10825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SH04_RS10825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SH04_RS10825	COG0674	pyruvate-flavodoxin oxidoreductase activity
SH04_RS10825	COG1013	pyruvate-flavodoxin oxidoreductase activity
SH04_RS10830	COG3042	response to heat
SH04_RS10835	COG3187	Heat shock protein
SH04_RS10840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SH04_RS10845	COG2911	Protein conserved in bacteria
SH04_RS10855	COG3784	Protein of unknown function (DUF1318)
SH04_RS10860	COG2207	Transcriptional regulator
SH04_RS10865	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS10870	COG3733	amine oxidase
SH04_RS10875	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS10875	COG2030	dehydratase
SH04_RS10880	COG3396	Phenylacetate-CoA oxygenase
SH04_RS10885	COG3460	Phenylacetate-CoA oxygenase
SH04_RS10890	COG3396	Phenylacetate-CoA oxygenase
SH04_RS10895	COG2151	metal-sulfur cluster biosynthetic enzyme
SH04_RS10900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SH04_RS10905	COG1024	Enoyl-CoA hydratase
SH04_RS10910	COG1024	Enoyl-CoA hydratase
SH04_RS10915	COG1250	3-hydroxyacyl-CoA dehydrogenase
SH04_RS10920	COG2050	protein possibly involved in aromatic compounds catabolism
SH04_RS10925	COG0183	Belongs to the thiolase family
SH04_RS10930	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SH04_RS10935	COG3327	negative regulation of DNA-templated transcription, initiation
SH04_RS10940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SH04_RS10960	COG2826	transposase and inactivated derivatives, IS30 family
SH04_RS10970	COG0667	Aldo Keto reductase
SH04_RS10980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SH04_RS10985	COG4589	Belongs to the CDS family
SH04_RS10990	COG2267	carboxylic ester hydrolase activity
SH04_RS10995	COG2453	phosphatase
SH04_RS10995	COG0671	phosphoesterase, PA-phosphatase related
SH04_RS11005	COG1643	Atp-dependent helicase
SH04_RS11010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SH04_RS11015	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS11020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SH04_RS11025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SH04_RS11030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SH04_RS11035	COG3038	cytochrome b561
SH04_RS11050	COG0840	transmembrane signaling receptor activity
SH04_RS11055	COG0583	DNA-binding transcription factor activity
SH04_RS11060	COG5383	Protein conserved in bacteria
SH04_RS11075	COG2841	Protein conserved in bacteria
SH04_RS11080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH04_RS11085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SH04_RS11090	COG1275	C4-dicarboxylate transporter malic acid transport protein
SH04_RS11095	COG0500	methyltransferase
SH04_RS11115	COG0675	Transposase, IS605 OrfB family
SH04_RS11120	COG3135	benzoate transporter
SH04_RS11125	COG1396	sequence-specific DNA binding
SH04_RS11130	COG0826	peptidase U32
SH04_RS11140	COG1724	mRNA binding
SH04_RS11145	COG1598	PFAM Uncharacterised protein family UPF0150
SH04_RS11150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SH04_RS11155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SH04_RS11160	COG3842	ATPase activity
SH04_RS11165	COG1176	ABC-type spermidine putrescine transport system, permease component I
SH04_RS11170	COG1177	transmembrane transport
SH04_RS11195	COG3238	Protein conserved in bacteria
SH04_RS11200	COG1247	-acetyltransferase
SH04_RS11205	COG2130	NADP-dependent
SH04_RS11210	COG1802	Transcriptional regulator
SH04_RS11215	COG4772	TonB-dependent receptor
SH04_RS11220	COG3391	amine dehydrogenase activity
SH04_RS11225	COG1113	amino acid transport
SH04_RS11230	COG0625	glutathione transferase activity
SH04_RS11240	COG3209	COG3209 Rhs family protein
SH04_RS11250	COG5433	transposase activity
SH04_RS11255	COG5433	transposase activity
SH04_RS11265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SH04_RS11270	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SH04_RS11275	COG0384	phenazine biosynthesis protein PhzF
SH04_RS11280	COG2181	nitrate reductase activity
SH04_RS11285	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SH04_RS11290	COG1140	nitrate reductase beta subunit
SH04_RS11295	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SH04_RS11300	COG2223	nitrite transmembrane transporter activity
SH04_RS11310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SH04_RS11315	COG0697	spore germination
SH04_RS11320	COG3383	formate dehydrogenase (NAD+) activity
SH04_RS11320	COG0243	molybdopterin cofactor binding
SH04_RS11325	COG0243	molybdopterin cofactor binding
SH04_RS11325	COG3383	formate dehydrogenase (NAD+) activity
SH04_RS11330	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS11335	COG2864	formate dehydrogenase
SH04_RS11340	COG3093	addiction module antidote protein HigA
SH04_RS11345	COG1064	alcohol dehydrogenase
SH04_RS11365	COG1764	response to oxidative stress
SH04_RS11370	COG4608	Belongs to the ABC transporter superfamily
SH04_RS11375	COG0444	Belongs to the ABC transporter superfamily
SH04_RS11380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH04_RS11385	COG0601	transmembrane transport
SH04_RS11390	COG0747	negative chemotaxis
SH04_RS11395	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SH04_RS11400	COG2202	Pas domain
SH04_RS11400	COG2199	diguanylate cyclase activity
SH04_RS11400	COG2200	EAL domain
SH04_RS11405	COG3706	GGDEF domain
SH04_RS11410	COG1649	PFAM Uncharacterised BCR, COG1649
SH04_RS11415	COG0531	amino acid
SH04_RS11420	COG0076	glutamate decarboxylase activity
SH04_RS11430	COG0612	Peptidase, M16
SH04_RS11435	COG4771	TonB-dependent receptor
SH04_RS11440	COG4178	(ABC) transporter
SH04_RS11445	COG0641	radical SAM
SH04_RS11450	COG3119	arylsulfatase activity
SH04_RS11455	COG2207	Transcriptional regulator
SH04_RS11465	COG0243	molybdopterin cofactor binding
SH04_RS11470	COG3539	Fimbrial protein
SH04_RS11475	COG3539	Fimbrial protein
SH04_RS11480	COG3539	Fimbrial protein
SH04_RS11485	COG3188	usher protein
SH04_RS11490	COG4977	sequence-specific DNA binding
SH04_RS11495	COG3550	peptidyl-serine autophosphorylation
SH04_RS11500	COG1396	sequence-specific DNA binding
SH04_RS11510	COG2911	Protein conserved in bacteria
SH04_RS11510	COG3210	domain, Protein
SH04_RS11560	COG3781	membrane
SH04_RS11575	COG2199	diguanylate cyclase activity
SH04_RS11585	COG2066	Belongs to the glutaminase family
SH04_RS11590	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS11595	COG0583	DNA-binding transcription factor activity
SH04_RS11615	COG1846	Transcriptional regulator
SH04_RS11620	COG4977	sequence-specific DNA binding
SH04_RS11630	COG0697	spore germination
SH04_RS11635	COG2814	Major facilitator Superfamily
SH04_RS11645	COG3706	GGDEF domain
SH04_RS11650	COG3111	PFAM Bacterial OB fold (BOF) protein
SH04_RS11655	COG1546	Belongs to the CinA family
SH04_RS11660	COG0339	signal peptide processing
SH04_RS11665	COG4221	oxidoreductase activity
SH04_RS11670	COG1802	Transcriptional regulator
SH04_RS11680	COG0246	Mannitol dehydrogenase
SH04_RS11685	COG0477	Major facilitator Superfamily
SH04_RS11695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SH04_RS11700	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SH04_RS11705	COG5301	cellulose 1,4-beta-cellobiosidase activity
SH04_RS11710	COG4220	transposase activity
SH04_RS11720	COG5562	phage envelope protein
SH04_RS11735	COG1278	Cold shock
SH04_RS11745	COG3772	lysozyme
SH04_RS11760	COG1278	Cold shock
SH04_RS11765	COG1278	Cold shock
SH04_RS11770	COG0484	heat shock protein binding
SH04_RS11775	COG1403	HNH endonuclease
SH04_RS11795	COG2026	Addiction module toxin, RelE StbE family
SH04_RS11800	COG3077	Addiction module antitoxin, RelB DinJ family
SH04_RS11820	COG1396	sequence-specific DNA binding
SH04_RS11860	COG0582	viral genome integration into host DNA
SH04_RS11865	COG1063	alcohol dehydrogenase
SH04_RS11870	COG4948	Mandelate Racemase Muconate Lactonizing
SH04_RS11885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH04_RS11900	COG0243	molybdopterin cofactor binding
SH04_RS11905	COG0243	molybdopterin cofactor binding
SH04_RS11910	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS11915	COG3302	dmso reductase anchor subunit
SH04_RS11920	COG3381	protein complex oligomerization
SH04_RS11930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SH04_RS11935	COG1940	carbohydrate kinase activity
SH04_RS11940	COG0583	DNA-binding transcription factor activity
SH04_RS11945	COG2814	Major facilitator Superfamily
SH04_RS11960	COG3591	Belongs to the peptidase S1B family
SH04_RS11975	COG0628	permease
SH04_RS11980	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SH04_RS11985	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SH04_RS11995	COG0531	amino acid
SH04_RS12005	COG3136	membrane protein required for alginate biosynthesis
SH04_RS12010	COG0745	RESPONSE REGULATOR receiver
SH04_RS12015	COG2205	protein histidine kinase activity
SH04_RS12025	COG0114	fumarate hydratase activity
SH04_RS12030	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SH04_RS12030	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SH04_RS12035	COG1482	cell wall glycoprotein biosynthetic process
SH04_RS12040	COG5339	Protein conserved in bacteria
SH04_RS12050	COG2211	Major facilitator Superfamily
SH04_RS12055	COG3250	beta-galactosidase activity
SH04_RS12060	COG1309	transcriptional regulator
SH04_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS12070	COG1609	Transcriptional regulator
SH04_RS12075	COG1263	PTS System
SH04_RS12075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS12080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SH04_RS12090	COG0673	inositol 2-dehydrogenase activity
SH04_RS12130	COG4659	FMN binding
SH04_RS12140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SH04_RS12150	COG3104	oligopeptide transport
SH04_RS12155	COG0625	glutathione transferase activity
SH04_RS12160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SH04_RS12175	COG3895	Periplasmic Protein
SH04_RS12185	COG3133	Outer membrane lipoprotein
SH04_RS12200	COG1566	PFAM secretion protein HlyD family protein
SH04_RS12205	COG1289	transmembrane transporter activity
SH04_RS12210	COG2032	superoxide dismutase activity
SH04_RS12215	COG4989	oxidoreductase activity
SH04_RS12220	COG3313	Fe-S protein
SH04_RS12225	COG1309	transcriptional regulator
SH04_RS12230	COG1902	pentaerythritol trinitrate reductase activity
SH04_RS12235	COG0346	lactoylglutathione lyase activity
SH04_RS12240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH04_RS12245	COG1201	RNA secondary structure unwinding
SH04_RS12250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SH04_RS12255	COG0791	NLP P60 protein
SH04_RS12260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SH04_RS12265	COG2814	Major facilitator Superfamily
SH04_RS12280	COG0583	DNA-binding transcription factor activity
SH04_RS12285	COG2814	Major facilitator Superfamily
SH04_RS12290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SH04_RS12295	COG0307	riboflavin synthase, alpha
SH04_RS12305	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS12325	COG4529	Protein conserved in bacteria
SH04_RS12335	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SH04_RS12340	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS12350	COG2414	aldehyde ferredoxin oxidoreductase
SH04_RS12355	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS12365	COG0469	pyruvate kinase activity
SH04_RS12370	COG4238	major outer membrane lipoprotein
SH04_RS12375	COG1376	ErfK ybiS ycfS ynhG family protein
SH04_RS12390	COG0719	Fe-S assembly protein
SH04_RS12395	COG0396	ATPase activity
SH04_RS12400	COG0719	Fe-S assembly protein
SH04_RS12405	COG0316	Belongs to the HesB IscA family
SH04_RS12415	COG2050	protein possibly involved in aromatic compounds catabolism
SH04_RS12420	COG0277	FAD linked oxidase domain protein
SH04_RS12420	COG0247	lactate metabolic process
SH04_RS12425	COG0628	permease
SH04_RS12435	COG0738	Major facilitator superfamily
SH04_RS12440	COG2271	Major facilitator Superfamily
SH04_RS12455	COG4670	ketone body catabolic process
SH04_RS12460	COG1960	acyl-CoA dehydrogenase activity
SH04_RS12465	COG1917	Cupin 2, conserved barrel domain protein
SH04_RS12465	COG2207	Transcriptional regulator
SH04_RS12475	COG2086	electron transfer activity
SH04_RS12480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SH04_RS12485	COG0644	oxidoreductase
SH04_RS12490	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SH04_RS12495	COG0318	PFAM AMP-dependent synthetase and ligase
SH04_RS12500	COG0574	Belongs to the PEP-utilizing enzyme family
SH04_RS12500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH04_RS12515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SH04_RS12520	COG4256	Hemin uptake protein
SH04_RS12530	COG2200	EAL domain
SH04_RS12535	COG0791	NLP P60 protein
SH04_RS12545	COG0386	Belongs to the glutathione peroxidase family
SH04_RS12560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH04_RS12560	COG0072	phenylalanine-tRNA ligase activity
SH04_RS12605	COG3137	Salt-induced outer membrane protein
SH04_RS12610	COG1105	Belongs to the carbohydrate kinase PfkB family
SH04_RS12620	COG3001	Fructosamine kinase
SH04_RS12630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH04_RS12635	COG1988	membrane-bound metal-dependent
SH04_RS12640	COG1823	symporter activity
SH04_RS12655	COG0753	catalase activity
SH04_RS12665	COG1486	melibiose metabolic process
SH04_RS12670	COG2169	Transcriptional regulator
SH04_RS12670	COG1917	Cupin 2, conserved barrel domain protein
SH04_RS12675	COG1447	Phosphotransferase system cellobiose-specific component IIA
SH04_RS12680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH04_RS12685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SH04_RS12690	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SH04_RS12705	COG0322	excinuclease ABC activity
SH04_RS12715	COG3678	ATP-independent chaperone mediated protein folding
SH04_RS12745	COG0708	Exodeoxyribonuclease III
SH04_RS12750	COG0398	Pfam SNARE associated Golgi protein
SH04_RS12760	COG0398	Pfam SNARE associated Golgi protein
SH04_RS12765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SH04_RS12770	COG4134	Bacterial extracellular solute-binding protein
SH04_RS12775	COG4135	transport system, permease component
SH04_RS12780	COG4136	ATPase activity
SH04_RS12785	COG2897	thiosulfate sulfurtransferase activity
SH04_RS12790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SH04_RS12795	COG0494	nUDIX hydrolase
SH04_RS12805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SH04_RS12815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SH04_RS12830	COG0778	Nitroreductase
SH04_RS12840	COG0616	signal peptide processing
SH04_RS12845	COG0252	asparaginase activity
SH04_RS12850	COG1335	isochorismatase
SH04_RS12855	COG2814	Major facilitator Superfamily
SH04_RS12860	COG1349	DNA-binding transcription factor activity
SH04_RS12865	COG0667	Aldo Keto reductase
SH04_RS12870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS12875	COG0191	fructose-bisphosphate aldolase activity
SH04_RS12880	COG1063	alcohol dehydrogenase
SH04_RS12885	COG2271	Major facilitator Superfamily
SH04_RS12890	COG1063	alcohol dehydrogenase
SH04_RS12895	COG3139	Protein of unknown function (DUF1315)
SH04_RS12905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SH04_RS12910	COG0676	glucose-6-phosphate 1-epimerase activity
SH04_RS12915	COG0656	L-ascorbic acid biosynthetic process
SH04_RS12920	COG3713	MltA-interacting MipA family protein
SH04_RS12925	COG2766	serine protein kinase
SH04_RS12935	COG2199	diguanylate cyclase activity
SH04_RS12940	COG2199	diguanylate cyclase activity
SH04_RS12945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SH04_RS12960	COG2207	Transcriptional regulator
SH04_RS12965	COG2807	transmembrane transport
SH04_RS12970	COG3189	MarR family transcriptional regulator
SH04_RS12975	COG3042	response to heat
SH04_RS12980	COG2199	diguanylate cyclase activity
SH04_RS12980	COG2203	Gaf domain
SH04_RS12990	COG2261	transglycosylase associated protein
SH04_RS13000	COG3615	Tellurite resistance protein tehB
SH04_RS13010	COG0583	DNA-binding transcription factor activity
SH04_RS13015	COG0473	3-isopropylmalate dehydrogenase activity
SH04_RS13020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SH04_RS13025	COG4638	Rieske (2fe-2S)
SH04_RS13030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SH04_RS13035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SH04_RS13040	COG0318	PFAM AMP-dependent synthetase and ligase
SH04_RS13045	COG3065	identical protein binding
SH04_RS13050	COG1214	PFAM Peptidase M22, glycoprotease
SH04_RS13055	COG1199	ATP-dependent helicase activity
SH04_RS13060	COG0251	oxidation-reduction process
SH04_RS13075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SH04_RS13085	COG1760	l-serine dehydratase
SH04_RS13090	COG2200	EAL domain
SH04_RS13095	COG1253	flavin adenine dinucleotide binding
SH04_RS13105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS13105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS13110	COG3715	PTS system
SH04_RS13115	COG3716	PTS system mannose fructose sorbose family IID component
SH04_RS13135	COG2226	methyltransferase
SH04_RS13170	COG1414	Transcriptional regulator
SH04_RS13175	COG2814	Major facilitator Superfamily
SH04_RS13185	COG0793	Belongs to the peptidase S41A family
SH04_RS13195	COG1956	GAF domain-containing protein
SH04_RS13200	COG2995	paraquat-inducible protein a
SH04_RS13205	COG3008	intermembrane lipid transfer
SH04_RS13225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SH04_RS13240	COG1276	copper resistance
SH04_RS13245	COG2372	response to copper ion
SH04_RS13255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SH04_RS13260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH04_RS13265	COG1770	oligopeptidase
SH04_RS13270	COG2979	Protein of unknown function (DUF533)
SH04_RS13285	COG3141	response to X-ray
SH04_RS13295	COG0800	Aldolase
SH04_RS13300	COG0129	dihydroxy-acid dehydratase activity
SH04_RS13305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SH04_RS13315	COG1737	Transcriptional regulator
SH04_RS13320	COG0469	pyruvate kinase activity
SH04_RS13325	COG1560	Kdo2-lipid A biosynthetic process
SH04_RS13330	COG0739	heme binding
SH04_RS13335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
SH04_RS13345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SH04_RS13370	COG0217	transcriptional regulatory protein
SH04_RS13375	COG0494	nUDIX hydrolase
SH04_RS13385	COG1335	isochorismatase
SH04_RS13390	COG1801	Protein of unknown function DUF72
SH04_RS13395	COG3788	relative of glutathione S-transferase, MAPEG superfamily
SH04_RS13410	COG0243	molybdopterin cofactor binding
SH04_RS13415	COG3005	denitrification pathway
SH04_RS13425	COG3102	Protein conserved in bacteria
SH04_RS13435	COG3755	Protein conserved in bacteria
SH04_RS13445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SH04_RS13450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SH04_RS13455	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SH04_RS13460	COG0745	RESPONSE REGULATOR receiver
SH04_RS13465	COG2201	protein-glutamate methylesterase activity
SH04_RS13470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SH04_RS13475	COG0840	transmembrane signaling receptor activity
SH04_RS13480	COG0840	transmembrane signaling receptor activity
SH04_RS13485	COG0835	chemotaxis
SH04_RS13490	COG2198	Histidine kinase
SH04_RS13490	COG0643	Histidine kinase
SH04_RS13495	COG1360	Flagellar Motor Protein
SH04_RS13500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SH04_RS13515	COG0589	response to stress
SH04_RS13525	COG1877	trehalose-phosphatase activity
SH04_RS13530	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH04_RS13535	COG1129	ABC transporter
SH04_RS13540	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS13545	COG1528	Iron-storage protein
SH04_RS13565	COG1528	Iron-storage protein
SH04_RS13575	COG0814	amino acid
SH04_RS13580	COG3012	SEC-C Motif Domain Protein
SH04_RS13580	COG3318	Belongs to the UPF0149 family
SH04_RS13610	COG2197	response regulator
SH04_RS13625	COG2197	response regulator
SH04_RS13630	COG1126	abc transporter atp-binding protein
SH04_RS13635	COG0765	amino acid transport
SH04_RS13645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS13655	COG1191	sigma factor activity
SH04_RS13660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SH04_RS13665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SH04_RS13670	COG1516	flagellar protein fliS
SH04_RS13680	COG0366	Alpha amylase catalytic
SH04_RS13690	COG2391	methyltransferase activity
SH04_RS13695	COG0425	Belongs to the sulfur carrier protein TusA family
SH04_RS13700	COG2135	peptidase activity
SH04_RS13705	COG0454	-acetyltransferase
SH04_RS13730	COG1766	The M ring may be actively involved in energy transduction
SH04_RS13735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SH04_RS13740	COG1317	bacterial-type flagellum organization
SH04_RS13745	COG1157	protein secretion by the type III secretion system
SH04_RS13750	COG2882	bacterial-type flagellum organization
SH04_RS13755	COG3144	bacterial-type flagellum assembly
SH04_RS13760	COG1580	Controls the rotational direction of flagella during chemotaxis
SH04_RS13765	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SH04_RS13770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SH04_RS13775	COG3190	flagellar
SH04_RS13780	COG1338	Plays a role in the flagellum-specific transport system
SH04_RS13785	COG1987	bacterial-type flagellum assembly
SH04_RS13790	COG1684	flagellar biosynthetic protein fliR
SH04_RS13795	COG2197	response regulator
SH04_RS13815	COG3706	GGDEF domain
SH04_RS13820	COG5475	Uncharacterized small protein (DUF2158)
SH04_RS13825	COG2354	Protein conserved in bacteria
SH04_RS13830	COG0697	spore germination
SH04_RS13835	COG3727	T/G mismatch-specific endonuclease activity
SH04_RS13840	COG0270	DNA (cytosine-5-)-methyltransferase activity
SH04_RS13845	COG1418	mRNA catabolic process
SH04_RS13875	COG2205	protein histidine kinase activity
SH04_RS13880	COG0745	RESPONSE REGULATOR receiver
SH04_RS13885	COG2351	hydroxyisourate hydrolase activity
SH04_RS13900	COG3443	Belongs to the bacterial solute-binding protein 9 family
SH04_RS13905	COG3038	cytochrome b561
SH04_RS13930	COG1388	LysM domain
SH04_RS13930	COG1470	cell adhesion involved in biofilm formation
SH04_RS13940	COG0477	Major facilitator Superfamily
SH04_RS13945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SH04_RS13950	COG0217	transcriptional regulatory protein
SH04_RS13960	COG0534	Mate efflux family protein
SH04_RS13970	COG0583	DNA-binding transcription factor activity
SH04_RS13975	COG0583	DNA-binding transcription factor activity
SH04_RS13985	COG1376	ErfK ybiS ycfS ynhG family protein
SH04_RS14000	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SH04_RS14010	COG3039	Transposase
SH04_RS14030	COG4771	TonB-dependent receptor
SH04_RS14040	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS14050	COG2003	Belongs to the UPF0758 family
SH04_RS14090	COG1289	transmembrane transporter activity
SH04_RS14100	COG1686	Belongs to the peptidase S11 family
SH04_RS14105	COG2925	Exonuclease
SH04_RS14110	COG0425	Belongs to the sulfur carrier protein TusA family
SH04_RS14115	COG2391	methyltransferase activity
SH04_RS14120	COG0531	amino acid
SH04_RS14125	COG0583	DNA-binding transcription factor activity
SH04_RS14130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SH04_RS14135	COG4115	mRNA cleavage
SH04_RS14140	COG2161	toxin-antitoxin pair type II binding
SH04_RS14150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SH04_RS14160	COG0131	Imidazoleglycerol-phosphate dehydratase
SH04_RS14160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SH04_RS14165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SH04_RS14180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SH04_RS14180	COG0140	phosphoribosyl-ATP diphosphatase activity
SH04_RS14185	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
SH04_RS14190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SH04_RS14195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SH04_RS14210	COG0438	transferase activity, transferring glycosyl groups
SH04_RS14215	COG0110	maltose O-acetyltransferase activity
SH04_RS14220	COG0438	transferase activity, transferring glycosyl groups
SH04_RS14230	COG0562	UDP-galactopyranose mutase
SH04_RS14235	COG2244	polysaccharide biosynthetic process
SH04_RS14240	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SH04_RS14245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SH04_RS14255	COG1088	dTDP-glucose 4,6-dehydratase activity
SH04_RS14260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SH04_RS14270	COG0438	transferase activity, transferring glycosyl groups
SH04_RS14275	COG2327	Polysaccharide pyruvyl transferase
SH04_RS14280	COG2244	polysaccharide biosynthetic process
SH04_RS14285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SH04_RS14290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SH04_RS14295	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SH04_RS14295	COG0662	Cupin 2, conserved barrel domain protein
SH04_RS14300	COG0297	glycogen (starch) synthase activity
SH04_RS14305	COG1051	belongs to the nudix hydrolase family
SH04_RS14310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SH04_RS14315	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SH04_RS14320	COG0110	maltose O-acetyltransferase activity
SH04_RS14325	COG1216	Glycosyl transferase, family 2
SH04_RS14335	COG0438	transferase activity, transferring glycosyl groups
SH04_RS14340	COG1045	serine acetyltransferase
SH04_RS14345	COG0463	Glycosyl transferase, family 2
SH04_RS14350	COG3206	protein involved in exopolysaccharide biosynthesis
SH04_RS14350	COG0489	protein tyrosine kinase activity
SH04_RS14355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SH04_RS14360	COG1596	polysaccharide export
SH04_RS14365	COG1253	flavin adenine dinucleotide binding
SH04_RS14370	COG2982	Protein involved in outer membrane biogenesis
SH04_RS14380	COG0572	uridine kinase
SH04_RS14385	COG3447	MASE1 domain protein
SH04_RS14385	COG5001	Diguanylate cyclase
SH04_RS14385	COG5002	protein histidine kinase activity
SH04_RS14390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SH04_RS14400	COG0443	Heat shock 70 kDa protein
SH04_RS14405	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
SH04_RS14410	COG3779	Protein conserved in bacteria
SH04_RS14415	COG0631	protein serine/threonine phosphatase activity
SH04_RS14420	COG4245	von Willebrand factor, type A
SH04_RS14445	COG2205	protein histidine kinase activity
SH04_RS14450	COG0745	RESPONSE REGULATOR receiver
SH04_RS14455	COG3422	double-strand break repair
SH04_RS14460	COG0826	peptidase U32
SH04_RS14495	COG2801	Transposase and inactivated derivatives
SH04_RS14505	COG1063	alcohol dehydrogenase
SH04_RS14510	COG3775	system Galactitol-specific IIC component
SH04_RS14515	COG3414	Phosphotransferase system galactitol-specific IIB component
SH04_RS14520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS14535	COG1830	Aldolase
SH04_RS14540	COG2211	Major facilitator Superfamily
SH04_RS14545	COG1397	ADP-ribosylglycohydrolase
SH04_RS14550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS14555	COG2188	Transcriptional regulator
SH04_RS14560	COG3757	hydrolase, family 25
SH04_RS14565	COG0351	phosphomethylpyrimidine kinase
SH04_RS14580	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SH04_RS14585	COG5455	response to cobalt ion
SH04_RS14590	COG3539	Fimbrial protein
SH04_RS14595	COG3188	usher protein
SH04_RS14600	COG3121	Chaperone
SH04_RS14605	COG3539	Fimbrial protein
SH04_RS14620	COG0489	protein tyrosine kinase activity
SH04_RS14640	COG3831	ATPase activity
SH04_RS14650	COG0714	Associated with various cellular activities
SH04_RS14655	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SH04_RS14660	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SH04_RS14665	COG4715	Zinc finger, swim domain protein
SH04_RS14670	COG4808	Protein conserved in bacteria
SH04_RS14675	COG4807	Protein conserved in bacteria
SH04_RS14680	COG3279	Response regulator of the LytR AlgR family
SH04_RS14685	COG3275	phosphorelay sensor kinase activity
SH04_RS14690	COG0789	Transcriptional regulator
SH04_RS14700	COG1174	glycine betaine transport
SH04_RS14705	COG1125	glycine betaine transport
SH04_RS14710	COG1174	glycine betaine transport
SH04_RS14715	COG1732	Glycine betaine
SH04_RS14720	COG1472	Belongs to the glycosyl hydrolase 3 family
SH04_RS14725	COG0277	FAD linked oxidase domain protein
SH04_RS14730	COG1686	Belongs to the peptidase S11 family
SH04_RS14740	COG0586	Pfam SNARE associated Golgi protein
SH04_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS14760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SH04_RS14770	COG1346	cytolysis
SH04_RS14780	COG2949	membrane
SH04_RS14790	COG0493	'glutamate synthase
SH04_RS14795	COG0167	dihydroorotate dehydrogenase activity
SH04_RS14795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SH04_RS14800	COG4211	Belongs to the binding-protein-dependent transport system permease family
SH04_RS14815	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS14820	COG1609	Transcriptional regulator
SH04_RS14830	COG2311	Membrane
SH04_RS14850	COG4771	TonB-dependent receptor
SH04_RS14855	COG0833	amino acid
SH04_RS14860	COG0583	DNA-binding transcription factor activity
SH04_RS14865	COG2855	membrane
SH04_RS14875	COG1522	sequence-specific DNA binding
SH04_RS14875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS14880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SH04_RS14890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH04_RS14895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SH04_RS14900	COG2313	pseudouridylate synthase activity
SH04_RS14905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS14910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS14910	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SH04_RS14910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS14915	COG1105	Belongs to the carbohydrate kinase PfkB family
SH04_RS14920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS14920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS14925	COG2814	Major facilitator Superfamily
SH04_RS14940	COG0246	Mannitol dehydrogenase
SH04_RS14945	COG0523	cobalamin synthesis protein
SH04_RS14950	COG0671	phosphoesterase, PA-phosphatase related
SH04_RS14955	COG0791	NLP P60 protein
SH04_RS14960	COG2200	EAL domain
SH04_RS14965	COG4166	transmembrane transport
SH04_RS14970	COG4174	ABC transporter (Permease)
SH04_RS14975	COG4239	(ABC) transporter, permease
SH04_RS14980	COG4172	Belongs to the ABC transporter superfamily
SH04_RS14990	COG2814	Major facilitator Superfamily
SH04_RS14995	COG1187	pseudouridine synthase activity
SH04_RS15000	COG1061	Type III restriction enzyme res subunit
SH04_RS15020	COG3083	sulfuric ester hydrolase activity
SH04_RS15030	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS15045	COG2197	response regulator
SH04_RS15050	COG4235	cytochrome complex assembly
SH04_RS15050	COG3088	subunit of a heme lyase
SH04_RS15055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SH04_RS15060	COG1138	Cytochrome C-type biogenesis protein
SH04_RS15070	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SH04_RS15075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SH04_RS15080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SH04_RS15085	COG4133	protoheme IX ABC transporter activity
SH04_RS15090	COG3005	denitrification pathway
SH04_RS15095	COG3043	anaerobic respiration
SH04_RS15100	COG0348	domain, Protein
SH04_RS15105	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS15115	COG3062	negative regulation of establishment of protein localization
SH04_RS15120	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS15120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS15140	COG4615	Cyclic peptide transporter
SH04_RS15145	COG3145	DNA-N1-methyladenine dioxygenase activity
SH04_RS15150	COG2169	Transcriptional regulator
SH04_RS15150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SH04_RS15155	COG1477	protein flavinylation
SH04_RS15160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SH04_RS15175	COG0642	Histidine kinase
SH04_RS15175	COG2198	Histidine kinase
SH04_RS15180	COG2197	response regulator
SH04_RS15185	COG2205	protein histidine kinase activity
SH04_RS15185	COG0784	Response regulator, receiver
SH04_RS15190	COG3852	Histidine kinase
SH04_RS15195	COG2204	response regulator
SH04_RS15200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SH04_RS15205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SH04_RS15210	COG2031	fatty acid transporter
SH04_RS15215	COG0183	Belongs to the thiolase family
SH04_RS15220	COG4676	Protein conserved in bacteria
SH04_RS15225	COG5445	Predicted secreted protein (DUF2300)
SH04_RS15240	COG3234	Protein of unknown function (DUF1175)
SH04_RS15245	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
SH04_RS15250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SH04_RS15260	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS15270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH04_RS15275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH04_RS15280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SH04_RS15285	COG3642	lipopolysaccharide core region biosynthetic process
SH04_RS15290	COG0583	DNA-binding transcription factor activity
SH04_RS15295	COG0584	glycerophosphoryl diester phosphodiesterase
SH04_RS15300	COG2271	Major facilitator Superfamily
SH04_RS15305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SH04_RS15315	COG0247	lactate metabolic process
SH04_RS15320	COG5464	transposase or invertase
SH04_RS15335	COG2271	Major facilitator Superfamily
SH04_RS15345	COG1414	Transcriptional regulator
SH04_RS15410	COG0318	PFAM AMP-dependent synthetase and ligase
SH04_RS15420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SH04_RS15435	COG1169	isochorismate synthase
SH04_RS15440	COG4575	ribosome binding
SH04_RS15445	COG2153	protein acetylation
SH04_RS15455	COG5160	protein modification by small protein removal
SH04_RS15460	COG2304	oxidoreductase activity
SH04_RS15465	COG2234	aminopeptidase activity
SH04_RS15485	COG0457	Tetratricopeptide repeat
SH04_RS15495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SH04_RS15500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SH04_RS15510	COG0839	Belongs to the complex I subunit 6 family
SH04_RS15525	COG1034	ATP synthesis coupled electron transport
SH04_RS15530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SH04_RS15535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SH04_RS15555	COG0583	DNA-binding transcription factor activity
SH04_RS15560	COG0436	Aminotransferase
SH04_RS15570	COG0471	metal ion transport
SH04_RS15570	COG0490	domain, Protein
SH04_RS15575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH04_RS15595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SH04_RS15600	COG0857	belongs to the CobB CobQ family
SH04_RS15600	COG0280	phosphate acetyltransferase
SH04_RS15605	COG1288	antiporter activity
SH04_RS15610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SH04_RS15615	COG0622	Phosphoesterase
SH04_RS15620	COG0625	glutathione transferase activity
SH04_RS15625	COG0625	glutathione transferase activity
SH04_RS15630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SH04_RS15635	COG1090	epimerase
SH04_RS15640	COG5464	transposase or invertase
SH04_RS15645	COG4598	ABC transporter
SH04_RS15650	COG4160	amino acid transport
SH04_RS15655	COG4215	(ABC) transporter
SH04_RS15660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS15665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS15670	COG0163	prenyltransferase activity
SH04_RS15675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SH04_RS15680	COG1286	toxin biosynthetic process
SH04_RS15685	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
SH04_RS15690	COG0285	dihydrofolate synthase activity
SH04_RS15700	COG0586	Pfam SNARE associated Golgi protein
SH04_RS15710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SH04_RS15725	COG2814	Major facilitator Superfamily
SH04_RS15730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SH04_RS15745	COG3101	peptidyl-lysine hydroxylation
SH04_RS15750	COG0730	response to heat
SH04_RS15765	COG2890	protein-(glutamine-N5) methyltransferase activity
SH04_RS15780	COG3539	Fimbrial protein
SH04_RS15785	COG3539	Fimbrial protein
SH04_RS15790	COG3539	Fimbrial protein
SH04_RS15795	COG3121	Chaperone
SH04_RS15805	COG3539	Fimbrial protein
SH04_RS15810	COG2062	phosphohistidine phosphatase, SixA
SH04_RS15825	COG3691	Protein conserved in bacteria
SH04_RS15830	COG2067	long-chain fatty acid transport protein
SH04_RS15840	COG2853	Lipoprotein
SH04_RS15845	COG2116	formate transmembrane transporter activity
SH04_RS15855	COG0582	viral genome integration into host DNA
SH04_RS15860	COG2246	polysaccharide biosynthetic process
SH04_RS15865	COG0463	Glycosyl transferase, family 2
SH04_RS15890	COG4725	Belongs to the MT-A70-like family
SH04_RS15915	COG5532	Uncharacterized conserved protein (DUF2303)
SH04_RS15920	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SH04_RS15940	COG0583	DNA-binding transcription factor activity
SH04_RS15945	COG2610	gluconate transmembrane transporter activity
SH04_RS15955	COG0477	Major facilitator Superfamily
SH04_RS15960	COG1566	PFAM secretion protein HlyD family protein
SH04_RS15965	COG2197	response regulator
SH04_RS15970	COG0784	Response regulator, receiver
SH04_RS15970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS15970	COG2198	Histidine kinase
SH04_RS15970	COG2205	protein histidine kinase activity
SH04_RS15975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SH04_RS15980	COG0679	Auxin Efflux Carrier
SH04_RS15985	COG0028	Belongs to the TPP enzyme family
SH04_RS16015	COG1560	Kdo2-lipid A biosynthetic process
SH04_RS16020	COG0436	Aminotransferase
SH04_RS16025	COG3275	phosphorelay sensor kinase activity
SH04_RS16030	COG3279	Response regulator of the LytR AlgR family
SH04_RS16035	COG2207	Transcriptional regulator
SH04_RS16040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS16040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS16040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH04_RS16045	COG1363	Peptidase, m42
SH04_RS16050	COG0006	proline dipeptidase activity
SH04_RS16055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS16060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SH04_RS16090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SH04_RS16095	COG3385	transposase activity
SH04_RS16100	COG2199	diguanylate cyclase activity
SH04_RS16100	COG2200	EAL domain
SH04_RS16115	COG3415	Transposase
SH04_RS16120	COG3415	Transposase
SH04_RS16150	COG0583	DNA-binding transcription factor activity
SH04_RS16160	COG2211	Major facilitator Superfamily
SH04_RS16165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SH04_RS16175	COG0583	DNA-binding transcription factor activity
SH04_RS16180	COG0385	Bile acid
SH04_RS16185	COG3530	Putative quorum-sensing-regulated virulence factor
SH04_RS16205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SH04_RS16210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS16215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SH04_RS16220	COG2190	(PTS) system
SH04_RS16235	COG3831	ATPase activity
SH04_RS16235	COG4884	unkown
SH04_RS16240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SH04_RS16245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SH04_RS16250	COG4208	sulfate ABC transporter
SH04_RS16255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SH04_RS16260	COG4150	thiosulfate binding
SH04_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS16280	COG1263	PTS System
SH04_RS16280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS16285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SH04_RS16290	COG2837	iron assimilation
SH04_RS16305	COG0456	acetyltransferase
SH04_RS16310	COG0860	N-Acetylmuramoyl-L-alanine amidase
SH04_RS16320	COG2207	Transcriptional regulator
SH04_RS16325	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SH04_RS16330	COG4816	utilization protein
SH04_RS16340	COG4303	Ethanolamine ammonia lyase large subunit
SH04_RS16345	COG4819	ethanolamine utilization protein
SH04_RS16350	COG3192	ethanolamine utilization protein
SH04_RS16355	COG1454	alcohol dehydrogenase
SH04_RS16360	COG4820	ethanolamine utilization protein (EutJ)
SH04_RS16365	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS16370	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SH04_RS16375	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SH04_RS16380	COG0280	phosphate acetyltransferase
SH04_RS16385	COG4812	Cobalamin adenosyltransferase
SH04_RS16390	COG4766	ethanolamine catabolic process
SH04_RS16395	COG4917	ethanolamine utilization protein
SH04_RS16400	COG4810	utilization protein
SH04_RS16405	COG0280	phosphate acetyltransferase
SH04_RS16405	COG0281	malic enzyme
SH04_RS16410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SH04_RS16415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SH04_RS16420	COG5342	invasion associated locus B
SH04_RS16430	COG0493	'glutamate synthase
SH04_RS16430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS16435	COG3850	Histidine kinase
SH04_RS16440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SH04_RS16450	COG1393	Belongs to the ArsC family
SH04_RS16465	COG0400	carboxylic ester hydrolase activity
SH04_RS16470	COG1444	tRNA N-acetyltransferase activity
SH04_RS16475	COG2321	neutral zinc metallopeptidase
SH04_RS16490	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SH04_RS16500	COG2716	regulation of RNA biosynthetic process
SH04_RS16505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SH04_RS16510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS16515	COG0651	ATP synthesis coupled electron transport
SH04_RS16520	COG0650	Formate hydrogenlyase subunit 4
SH04_RS16525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SH04_RS16530	COG4237	Hydrogenase 4 membrane
SH04_RS16535	COG0651	ATP synthesis coupled electron transport
SH04_RS16540	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SH04_RS16540	COG3261	NADH dehydrogenase
SH04_RS16545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SH04_RS16550	COG3260	NADH ubiquinone oxidoreductase 20
SH04_RS16560	COG3604	Transcriptional regulator
SH04_RS16565	COG2116	formate transmembrane transporter activity
SH04_RS16570	COG0628	permease
SH04_RS16575	COG4783	chaperone-mediated protein folding
SH04_RS16580	COG1393	Belongs to the ArsC family
SH04_RS16590	COG2233	PERMEase
SH04_RS16605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SH04_RS16610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SH04_RS16615	COG0248	Ppx GppA phosphatase
SH04_RS16620	COG2200	EAL domain
SH04_RS16635	COG3133	Outer membrane lipoprotein
SH04_RS16650	COG0517	IMP dehydrogenase activity
SH04_RS16650	COG0516	GMP reductase activity
SH04_RS16660	COG1645	bacterial-type flagellum-dependent swarming motility
SH04_RS16670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SH04_RS16675	COG2976	Protein conserved in bacteria
SH04_RS16705	COG4953	penicillin-binding protein 1C
SH04_RS16710	COG2373	Large extracellular alpha-helical protein
SH04_RS16715	COG2897	thiosulfate sulfurtransferase activity
SH04_RS16730	COG2975	iron-sulfur cluster assembly
SH04_RS16735	COG0633	Ferredoxin
SH04_RS16755	COG0822	iron-sulfur transferase activity
SH04_RS16775	COG0483	inositol monophosphate 1-phosphatase activity
SH04_RS16780	COG1073	alpha beta
SH04_RS16785	COG3711	transcriptional antiterminator
SH04_RS16790	COG2814	Major facilitator Superfamily
SH04_RS16795	COG0583	DNA-binding transcription factor activity
SH04_RS16800	COG4638	Rieske (2fe-2S)
SH04_RS16825	COG2259	Doxx family
SH04_RS16830	COG2017	converts alpha-aldose to the beta-anomer
SH04_RS16835	COG1063	alcohol dehydrogenase
SH04_RS16840	COG1172	Belongs to the binding-protein-dependent transport system permease family
SH04_RS16845	COG1129	ABC transporter
SH04_RS16850	COG1879	ABC-type sugar transport system periplasmic component
SH04_RS16855	COG0457	Tetratricopeptide repeat
SH04_RS16860	COG1940	carbohydrate kinase activity
SH04_RS16870	COG1017	nitric oxide dioxygenase activity
SH04_RS16870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SH04_RS16875	COG0347	Belongs to the P(II) protein family
SH04_RS16880	COG2204	response regulator
SH04_RS16885	COG3170	Tfp pilus assembly protein FimV
SH04_RS16890	COG2205	protein histidine kinase activity
SH04_RS16895	COG0047	phosphoribosylformylglycinamidine synthase activity
SH04_RS16895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SH04_RS16910	COG0560	Phosphoserine phosphatase
SH04_RS16915	COG1737	Transcriptional regulator
SH04_RS16920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS16945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SH04_RS16965	COG0681	Belongs to the peptidase S26 family
SH04_RS16975	COG3086	response to oxidative stress
SH04_RS16980	COG3026	antisigma factor binding
SH04_RS16985	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
SH04_RS16990	COG1595	DNA-templated transcription, initiation
SH04_RS17000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SH04_RS17010	COG0513	Belongs to the DEAD box helicase family
SH04_RS17020	COG0583	DNA-binding transcription factor activity
SH04_RS17040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH04_RS17050	COG3118	belongs to the thioredoxin family
SH04_RS17055	COG3148	PFAM DTW domain containing protein
SH04_RS17060	COG1042	CoA-binding domain protein
SH04_RS17060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SH04_RS17060	COG0045	succinate-CoA ligase (ADP-forming) activity
SH04_RS17065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SH04_RS17070	COG5544	Lipoprotein
SH04_RS17075	COG0477	Major facilitator Superfamily
SH04_RS17105	COG0542	response to heat
SH04_RS17110	COG1496	oxidoreductase activity
SH04_RS17115	COG0564	pseudouridine synthase activity
SH04_RS17120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SH04_RS17130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SH04_RS17135	COG0077	Prephenate dehydratase
SH04_RS17135	COG1605	Chorismate mutase
SH04_RS17140	COG0287	Prephenate dehydrogenase
SH04_RS17140	COG1605	Chorismate mutase
SH04_RS17145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SH04_RS17160	COG2199	diguanylate cyclase activity
SH04_RS17165	COG2885	chlorophyll binding
SH04_RS17190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SH04_RS17195	COG4137	Cytochrome C assembly protein
SH04_RS17200	COG4536	flavin adenine dinucleotide binding
SH04_RS17220	COG0497	DNA recombination
SH04_RS17225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SH04_RS17235	COG2867	negative regulation of translational initiation
SH04_RS17245	COG0582	viral genome integration into host DNA
SH04_RS17255	COG3311	Transcriptional regulator
SH04_RS17260	COG4983	Phage plasmid primase, P4 family domain protein
SH04_RS17270	COG1204	response to ionizing radiation
SH04_RS17280	COG1479	Protein of unknown function DUF262
SH04_RS17295	COG3596	GTP binding
SH04_RS17305	COG2378	regulation of single-species biofilm formation
SH04_RS17345	COG2003	Belongs to the UPF0758 family
SH04_RS17360	COG3468	outer membrane autotransporter barrel domain protein
SH04_RS17395	COG0366	Alpha amylase catalytic
SH04_RS17400	COG0366	Alpha amylase catalytic
SH04_RS17405	COG0366	Alpha amylase catalytic
SH04_RS17415	COG0579	oxidoreductase
SH04_RS17420	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS17425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SH04_RS17430	COG1113	amino acid transport
SH04_RS17435	COG1802	Transcriptional regulator
SH04_RS17440	COG1652	LysM domain
SH04_RS17445	COG0401	homolog of Blt101
SH04_RS17450	COG0640	Transcriptional regulator
SH04_RS17455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SH04_RS17460	COG2916	Histone family protein nucleoid-structuring protein H-NS
SH04_RS17475	COG4575	ribosome binding
SH04_RS17480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SH04_RS17490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH04_RS17495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SH04_RS17500	COG4175	Glycine betaine
SH04_RS17505	COG4176	ABC-type proline glycine betaine transport system permease component
SH04_RS17510	COG2113	Glycine betaine
SH04_RS17520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SH04_RS17530	COG1846	Transcriptional regulator
SH04_RS17535	COG1566	PFAM secretion protein HlyD family protein
SH04_RS17540	COG2814	Major facilitator Superfamily
SH04_RS17555	COG1238	metal cluster binding
SH04_RS17560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SH04_RS17595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SH04_RS17630	COG1546	Belongs to the CinA family
SH04_RS17635	COG2951	lytic endotransglycosylase activity
SH04_RS17640	COG3730	PTS system glucitol sorbitol-specific
SH04_RS17645	COG3732	PTS system glucitol sorbitol-specific
SH04_RS17650	COG3731	PTS system glucitol sorbitol-specific IIA component
SH04_RS17655	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS17660	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS17665	COG1349	DNA-binding transcription factor activity
SH04_RS17670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SH04_RS17670	COG0517	IMP dehydrogenase activity
SH04_RS17690	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SH04_RS17695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS17700	COG1609	Transcriptional regulator
SH04_RS17705	COG1263	PTS System
SH04_RS17705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS17710	COG2723	6-phospho-beta-galactosidase activity
SH04_RS17715	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SH04_RS17725	COG3260	NADH ubiquinone oxidoreductase 20
SH04_RS17730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SH04_RS17735	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SH04_RS17735	COG3261	NADH dehydrogenase
SH04_RS17740	COG0650	Formate hydrogenlyase subunit 4
SH04_RS17745	COG0651	ATP synthesis coupled electron transport
SH04_RS17750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS17765	COG0375	protein maturation
SH04_RS17770	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SH04_RS17775	COG0298	carbon dioxide binding
SH04_RS17780	COG0409	Hydrogenase expression formation protein
SH04_RS17785	COG0309	Hydrogenase expression formation protein (HypE)
SH04_RS17790	COG3604	Transcriptional regulator
SH04_RS17805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SH04_RS17810	COG1349	DNA-binding transcription factor activity
SH04_RS17815	COG2084	Dehydrogenase
SH04_RS17820	COG3395	kinase activity
SH04_RS17825	COG0235	Class ii aldolase
SH04_RS17830	COG3622	Belongs to the hyi family
SH04_RS17835	COG2610	gluconate transmembrane transporter activity
SH04_RS17840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SH04_RS17845	COG1388	LysM domain
SH04_RS17845	COG4942	peptidase
SH04_RS17900	COG2234	aminopeptidase activity
SH04_RS17905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SH04_RS17910	COG1518	maintenance of DNA repeat elements
SH04_RS17925	COG1857	crispr-associated protein
SH04_RS17940	COG1203	CRISPR-associated helicase, Cas3
SH04_RS17955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SH04_RS17960	COG0720	synthase
SH04_RS17965	COG0644	oxidoreductase
SH04_RS17970	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SH04_RS17975	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SH04_RS17980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SH04_RS17985	COG2086	electron transfer activity
SH04_RS17990	COG0477	Major facilitator Superfamily
SH04_RS17995	COG0277	FAD linked oxidase domain protein
SH04_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS18005	COG2223	nitrite transmembrane transporter activity
SH04_RS18010	COG1070	Carbohydrate kinase
SH04_RS18015	COG0602	queuosine metabolic process
SH04_RS18025	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SH04_RS18040	COG3956	TIGRFAM MazG family protein
SH04_RS18045	COG2337	Toxic component of a toxin-antitoxin (TA) module
SH04_RS18050	COG2336	PFAM SpoVT AbrB
SH04_RS18055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SH04_RS18060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SH04_RS18065	COG2205	protein histidine kinase activity
SH04_RS18065	COG3437	response regulator, receiver
SH04_RS18065	COG3850	Histidine kinase
SH04_RS18065	COG4999	Histidine kinase
SH04_RS18070	COG4948	Mandelate Racemase Muconate Lactonizing
SH04_RS18075	COG4948	Mandelate Racemase Muconate Lactonizing
SH04_RS18080	COG2271	Major facilitator Superfamily
SH04_RS18085	COG0716	FMN binding
SH04_RS18090	COG0564	pseudouridine synthase activity
SH04_RS18095	COG3098	single-species biofilm formation
SH04_RS18115	COG1611	Belongs to the LOG family
SH04_RS18120	COG0814	amino acid
SH04_RS18125	COG1760	l-serine dehydratase
SH04_RS18135	COG1454	alcohol dehydrogenase
SH04_RS18140	COG0235	Class ii aldolase
SH04_RS18145	COG0738	Major facilitator superfamily
SH04_RS18155	COG1070	Carbohydrate kinase
SH04_RS18165	COG1349	DNA-binding transcription factor activity
SH04_RS18175	COG2363	Small membrane protein
SH04_RS18180	COG0583	DNA-binding transcription factor activity
SH04_RS18190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SH04_RS18195	COG2166	iron-sulfur cluster assembly
SH04_RS18200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SH04_RS18205	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SH04_RS18225	COG0860	N-Acetylmuramoyl-L-alanine amidase
SH04_RS18230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SH04_RS18230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SH04_RS18240	COG1074	ATP-dependent DNA helicase activity
SH04_RS18245	COG1025	Belongs to the peptidase M16 family
SH04_RS18250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SH04_RS18255	COG4967	type IV pilus modification protein PilV
SH04_RS18265	COG4795	General secretion pathway protein
SH04_RS18270	COG2165	general secretion pathway protein
SH04_RS18285	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
SH04_RS18310	COG0861	Integral membrane protein TerC family
SH04_RS18320	COG0667	Aldo Keto reductase
SH04_RS18335	COG1609	Transcriptional regulator
SH04_RS18345	COG0583	DNA-binding transcription factor activity
SH04_RS18350	COG1794	racemase activity, acting on amino acids and derivatives
SH04_RS18355	COG2814	Major facilitator Superfamily
SH04_RS18360	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS18370	COG0183	Belongs to the thiolase family
SH04_RS18375	COG0814	amino acid
SH04_RS18380	COG2771	luxR family
SH04_RS18385	COG3710	Transcriptional regulator
SH04_RS18405	COG0457	Tetratricopeptide repeat
SH04_RS18410	COG0457	Tetratricopeptide repeat
SH04_RS18410	COG3710	Transcriptional regulator
SH04_RS18425	COG2197	response regulator
SH04_RS18430	COG2197	response regulator
SH04_RS18460	COG3387	PFAM Glycoside hydrolase 15-related
SH04_RS18465	COG3387	PFAM Glycoside hydrolase 15-related
SH04_RS18475	COG4942	peptidase
SH04_RS18480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SH04_RS18485	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SH04_RS18490	COG2080	2 iron, 2 sulfur cluster binding
SH04_RS18495	COG3829	transcription factor binding
SH04_RS18500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SH04_RS18505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SH04_RS18510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SH04_RS18520	COG0549	Belongs to the carbamate kinase family
SH04_RS18525	COG3608	succinylglutamate desuccinylase aspartoacylase
SH04_RS18525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SH04_RS18530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SH04_RS18535	COG2068	MobA-Related Protein
SH04_RS18540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS18540	COG0493	'glutamate synthase
SH04_RS18545	COG0402	S-adenosylhomocysteine deaminase activity
SH04_RS18550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SH04_RS18555	COG2080	2 iron, 2 sulfur cluster binding
SH04_RS18555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SH04_RS18560	COG2233	PERMEase
SH04_RS18565	COG0402	S-adenosylhomocysteine deaminase activity
SH04_RS18570	COG2252	PERMEase
SH04_RS18575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS18580	COG0493	'glutamate synthase
SH04_RS18580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS18590	COG2233	PERMEase
SH04_RS18605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SH04_RS18615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SH04_RS18620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SH04_RS18625	COG4974	Belongs to the 'phage' integrase family
SH04_RS18630	COG0716	FMN binding
SH04_RS18640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SH04_RS18650	COG1272	protein, Hemolysin III
SH04_RS18660	COG2723	6-phospho-beta-galactosidase activity
SH04_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS18685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SH04_RS18690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SH04_RS18695	COG0006	proline dipeptidase activity
SH04_RS18710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SH04_RS18715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SH04_RS18735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SH04_RS18735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SH04_RS18740	COG1703	isobutyryl-CoA mutase activity
SH04_RS18745	COG1024	Enoyl-CoA hydratase
SH04_RS18750	COG0427	acetyl-CoA hydrolase
SH04_RS18755	COG0583	DNA-binding transcription factor activity
SH04_RS18760	COG2968	Membrane
SH04_RS18765	COG1279	arginine transmembrane transporter activity
SH04_RS18770	COG0668	transmembrane transport
SH04_RS18775	COG0191	fructose-bisphosphate aldolase activity
SH04_RS18790	COG1072	(Pantothenic acid kinase))
SH04_RS18795	COG3722	fumarate hydratase activity
SH04_RS18800	COG1494	fructose-1,6-bisphosphatase
SH04_RS18805	COG1063	alcohol dehydrogenase
SH04_RS18810	COG2213	PTS system mannitol-specific
SH04_RS18815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS18820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SH04_RS18825	COG0501	Belongs to the peptidase M48B family
SH04_RS18835	COG1166	arginine decarboxylase activity
SH04_RS18870	COG2356	endonuclease I
SH04_RS18875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SH04_RS18880	COG0189	ligase activity
SH04_RS18895	COG2805	Type II/IV secretion system protein
SH04_RS18900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SH04_RS18905	COG0762	integral membrane protein
SH04_RS18915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SH04_RS18920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SH04_RS18930	COG0252	asparaginase activity
SH04_RS18945	COG3171	Protein conserved in bacteria
SH04_RS18955	COG1194	a g-specific adenine glycosylase
SH04_RS18970	COG2211	Major facilitator Superfamily
SH04_RS18975	COG1982	Orn Lys Arg decarboxylase major
SH04_RS18980	COG1811	Na channel or pump
SH04_RS18990	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
SH04_RS19000	COG3031	protein transport across the cell outer membrane
SH04_RS19010	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SH04_RS19015	COG3064	Membrane
SH04_RS19025	COG1620	l-lactate permease
SH04_RS19030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SH04_RS19035	COG3193	protein, possibly involved in utilization of glycolate and propanediol
SH04_RS19040	COG0247	lactate metabolic process
SH04_RS19045	COG0277	FAD linked oxidase domain protein
SH04_RS19050	COG0277	FAD linked oxidase domain protein
SH04_RS19055	COG2186	Transcriptional regulator
SH04_RS19060	COG0456	acetyltransferase
SH04_RS19070	COG2244	polysaccharide biosynthetic process
SH04_RS19075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SH04_RS19080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SH04_RS19085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SH04_RS19090	COG0306	phosphate transporter
SH04_RS19095	COG0754	glutathionylspermidine amidase activity
SH04_RS19100	COG0625	glutathione transferase activity
SH04_RS19105	COG0298	carbon dioxide binding
SH04_RS19115	COG1773	rubredoxin
SH04_RS19120	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SH04_RS19125	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SH04_RS19130	COG5557	Pfam Polysulphide reductase, NrfD
SH04_RS19135	COG0437	4 iron, 4 sulfur cluster binding
SH04_RS19140	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SH04_RS19160	COG0667	Aldo Keto reductase
SH04_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
SH04_RS19175	COG0848	biopolymer transport protein
SH04_RS19180	COG0811	peptide transport
SH04_RS19190	COG0626	cystathionine gamma-synthase activity
SH04_RS19195	COG0586	Pfam SNARE associated Golgi protein
SH04_RS19200	COG2207	Transcriptional regulator
SH04_RS19210	COG1979	alcohol dehydrogenase
SH04_RS19215	COG0656	L-ascorbic acid biosynthetic process
SH04_RS19225	COG4238	major outer membrane lipoprotein
SH04_RS19230	COG1032	radical SAM domain protein
SH04_RS19235	COG2132	Multicopper oxidase
SH04_RS19240	COG0204	Acyl-transferase
SH04_RS19245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SH04_RS19250	COG4166	transmembrane transport
SH04_RS19255	COG2944	sequence-specific DNA binding
SH04_RS19265	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SH04_RS19270	COG3111	PFAM Bacterial OB fold (BOF) protein
SH04_RS19275	COG0745	RESPONSE REGULATOR receiver
SH04_RS19280	COG0642	Histidine kinase
SH04_RS19290	COG2249	NAD(P)H dehydrogenase (quinone) activity
SH04_RS19295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SH04_RS19300	COG0187	DNA topoisomerase II activity
SH04_RS19305	COG3150	esterase
SH04_RS19310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SH04_RS19315	COG3151	Protein conserved in bacteria
SH04_RS19320	COG0494	nUDIX hydrolase
SH04_RS19325	COG1538	Outer membrane efflux protein
SH04_RS19340	COG0754	glutathionylspermidine amidase activity
SH04_RS19345	COG3384	dioxygenase
SH04_RS19365	COG2960	long-chain fatty acid transporting porin activity
SH04_RS19370	COG3539	Fimbrial protein
SH04_RS19385	COG3188	usher protein
SH04_RS19390	COG3121	Chaperone
SH04_RS19395	COG3539	Fimbrial protein
SH04_RS19405	COG1585	Membrane protein implicated in regulation of membrane protease activity
SH04_RS19410	COG2268	Band 7 protein
SH04_RS19435	COG3025	triphosphatase activity
SH04_RS19445	COG4991	sh3 domain protein
SH04_RS19460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SH04_RS19470	COG0583	DNA-binding transcription factor activity
SH04_RS19475	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SH04_RS19485	COG0471	metal ion transport
SH04_RS19495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SH04_RS19500	COG0358	DNA primase activity
SH04_RS19505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SH04_RS19520	COG2375	cellular response to nickel ion
SH04_RS19525	COG1695	Transcriptional regulator
SH04_RS19530	COG0840	transmembrane signaling receptor activity
SH04_RS19540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SH04_RS19545	COG1609	Transcriptional regulator
SH04_RS19550	COG3250	beta-galactosidase activity
SH04_RS19555	COG2731	YhcH YjgK YiaL family protein
SH04_RS19560	COG0531	amino acid
SH04_RS19570	COG3408	Glycogen debranching enzyme
SH04_RS19570	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SH04_RS19575	COG1902	pentaerythritol trinitrate reductase activity
SH04_RS19575	COG0446	pyridine nucleotide-disulphide oxidoreductase
SH04_RS19580	COG5499	transcription regulator containing HTH domain
SH04_RS19585	COG4680	protein conserved in bacteria
SH04_RS19600	COG1451	nucleotide metabolic process
SH04_RS19605	COG2949	membrane
SH04_RS19610	COG0673	inositol 2-dehydrogenase activity
SH04_RS19615	COG0861	Integral membrane protein TerC family
SH04_RS19620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SH04_RS19630	COG2721	sulfolactate sulfo-lyase activity
SH04_RS19640	COG2271	Major facilitator Superfamily
SH04_RS19645	COG2186	Transcriptional regulator
SH04_RS19650	COG0586	Pfam SNARE associated Golgi protein
SH04_RS19660	COG1422	Protein of unknown function (DUF1090)
SH04_RS19665	COG4575	ribosome binding
SH04_RS19670	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
SH04_RS19680	COG2259	Doxx family
SH04_RS19685	COG0435	Glutathione S-transferase
SH04_RS19690	COG3152	Membrane
SH04_RS19695	COG3152	Membrane
SH04_RS19700	COG0583	DNA-binding transcription factor activity
SH04_RS19705	COG1741	Belongs to the pirin family
SH04_RS19720	COG0814	amino acid
SH04_RS19725	COG1760	l-serine dehydratase
SH04_RS19730	COG0251	oxidation-reduction process
SH04_RS19735	COG1882	Formate acetyltransferase
SH04_RS19750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SH04_RS19760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SH04_RS19765	COG0583	DNA-binding transcription factor activity
SH04_RS19785	COG1929	Belongs to the glycerate kinase type-1 family
SH04_RS19790	COG2084	Dehydrogenase
SH04_RS19800	COG2271	Major facilitator Superfamily
SH04_RS19805	COG2721	sulfolactate sulfo-lyase activity
SH04_RS19810	COG2002	toxin-antitoxin pair type II binding
SH04_RS19820	COG1349	DNA-binding transcription factor activity
SH04_RS19830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS19840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SH04_RS19845	COG2222	sugar isomerase
SH04_RS19855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS19860	COG3715	PTS system
SH04_RS19865	COG3716	PTS system mannose fructose sorbose family IID component
SH04_RS19870	COG0363	glucosamine-6-phosphate deaminase activity
SH04_RS19875	COG3539	Fimbrial protein
SH04_RS19880	COG3121	Chaperone
SH04_RS19885	COG3188	usher protein
SH04_RS19890	COG3539	Fimbrial protein
SH04_RS19895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SH04_RS19900	COG3107	peptidoglycan biosynthetic process
SH04_RS19915	COG2823	Periplasmic or secreted lipoprotein
SH04_RS19920	COG0701	Predicted permease
SH04_RS19925	COG0702	epimerase
SH04_RS19930	COG0693	protein deglycase activity
SH04_RS19945	COG3153	acetyltransferase
SH04_RS19950	COG3154	lipid carrier protein
SH04_RS19955	COG0826	peptidase U32
SH04_RS19960	COG0826	peptidase U32
SH04_RS19965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SH04_RS19970	COG0814	amino acid
SH04_RS19980	COG0513	Belongs to the DEAD box helicase family
SH04_RS20015	COG0195	Participates in both transcription termination and antitermination
SH04_RS20035	COG2194	sulfuric ester hydrolase activity
SH04_RS20045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SH04_RS20055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SH04_RS20060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SH04_RS20070	COG1534	Rna-binding protein
SH04_RS20075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SH04_RS20080	COG2027	D-alanyl-D-alanine carboxypeptidase
SH04_RS20090	COG0697	spore germination
SH04_RS20105	COG0142	geranyltranstransferase activity
SH04_RS20110	COG3423	Transcriptional regulator
SH04_RS20120	COG5007	Belongs to the BolA IbaG family
SH04_RS20125	COG3113	response to antibiotic
SH04_RS20130	COG2854	intermembrane phospholipid transfer
SH04_RS20135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SH04_RS20140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SH04_RS20145	COG1127	ABC transporter
SH04_RS20150	COG0530	calcium, potassium:sodium antiporter activity
SH04_RS20155	COG0517	IMP dehydrogenase activity
SH04_RS20155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SH04_RS20160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SH04_RS20165	COG3117	lipopolysaccharide transmembrane transporter activity
SH04_RS20170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SH04_RS20175	COG1137	ATPase activity
SH04_RS20180	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SH04_RS20185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SH04_RS20200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SH04_RS20205	COG0515	serine threonine protein kinase
SH04_RS20220	COG3539	Fimbrial protein
SH04_RS20225	COG4804	nuclease activity
SH04_RS20230	COG2731	YhcH YjgK YiaL family protein
SH04_RS20260	COG3069	C4-dicarboxylate transmembrane transporter activity
SH04_RS20265	COG2969	positive regulation of protein catabolic process
SH04_RS20270	COG0625	glutathione transferase activity
SH04_RS20285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SH04_RS20290	COG3105	Protein conserved in bacteria
SH04_RS20295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH04_RS20300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SH04_RS20320	COG2732	(Barnase) inhibitor
SH04_RS20340	COG0583	DNA-binding transcription factor activity
SH04_RS20345	COG0312	modulator of DNA gyrase
SH04_RS20350	COG3164	Protein of unknown function
SH04_RS20355	COG1530	ribonuclease E activity
SH04_RS20360	COG0424	maF-like protein
SH04_RS20365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SH04_RS20370	COG1792	Involved in formation and maintenance of cell shape
SH04_RS20375	COG1077	Cell shape determining protein MreB Mrl
SH04_RS20385	COG2200	EAL domain
SH04_RS20385	COG2199	diguanylate cyclase activity
SH04_RS20390	COG0604	alcohol dehydrogenase
SH04_RS20410	COG0511	ligase activity, forming carbon-carbon bonds
SH04_RS20415	COG0439	Biotin carboxylase
SH04_RS20420	COG3924	membrane
SH04_RS20425	COG4145	pantothenate transmembrane transporter activity
SH04_RS20435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SH04_RS20445	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SH04_RS20455	COG1309	transcriptional regulator
SH04_RS20460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS20465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SH04_RS20480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SH04_RS20485	COG4597	amino acid ABC transporter
SH04_RS20490	COG0765	amino acid transport
SH04_RS20495	COG1126	abc transporter atp-binding protein
SH04_RS20535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SH04_RS20555	COG0551	DNA topoisomerase type I activity
SH04_RS20565	COG0758	DNA mediated transformation
SH04_RS20585	COG0569	domain protein
SH04_RS20595	COG3036	rescue of stalled ribosome
SH04_RS20600	COG0789	Transcriptional regulator
SH04_RS20640	COG0201	protein transport
SH04_RS20730	COG0089	rRNA binding
SH04_RS20755	COG3409	Peptidoglycan-binding domain 1 protein
SH04_RS20755	COG3267	Type II secretory pathway component ExeA
SH04_RS20760	COG3031	protein transport across the cell outer membrane
SH04_RS20765	COG1450	Type ii and iii secretion system protein
SH04_RS20770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SH04_RS20775	COG1459	type II secretion system
SH04_RS20780	COG2165	general secretion pathway protein
SH04_RS20785	COG2165	general secretion pathway protein
SH04_RS20790	COG2165	general secretion pathway protein
SH04_RS20795	COG4795	General secretion pathway protein
SH04_RS20800	COG3156	type II secretion system protein K
SH04_RS20805	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
SH04_RS20810	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
SH04_RS20815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SH04_RS20820	COG2193	ferroxidase activity
SH04_RS20825	COG2906	2 iron, 2 sulfur cluster binding
SH04_RS20830	COG3979	chitinase
SH04_RS20870	COG2964	Protein conserved in bacteria
SH04_RS20875	COG0545	Peptidyl-prolyl cis-trans isomerase
SH04_RS20885	COG1047	Peptidyl-prolyl cis-trans
SH04_RS20890	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
SH04_RS20905	COG0488	(ABC) transporter
SH04_RS20910	COG0429	hydrolase of the alpha beta-hydrolase fold
SH04_RS20920	COG3954	Phosphoribulokinase
SH04_RS20925	COG1765	OsmC-like protein
SH04_RS20935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SH04_RS20940	COG1289	transmembrane transporter activity
SH04_RS20945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SH04_RS20950	COG0512	Glutamine amidotransferase of anthranilate synthase
SH04_RS20955	COG2184	nucleotidyltransferase activity
SH04_RS20965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SH04_RS20975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SH04_RS20980	COG2146	nitrite reductase [NAD(P)H] activity
SH04_RS20985	COG2116	formate transmembrane transporter activity
SH04_RS21000	COG0531	amino acid
SH04_RS21005	COG2222	sugar isomerase
SH04_RS21010	COG1082	Xylose isomerase domain protein TIM barrel
SH04_RS21015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS21020	COG2188	Transcriptional regulator
SH04_RS21025	COG0626	cystathionine gamma-synthase activity
SH04_RS21040	COG1735	metal-dependent hydrolase with the TIM-barrel fold
SH04_RS21045	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SH04_RS21050	COG3457	Alanine racemase
SH04_RS21060	COG2188	Transcriptional regulator
SH04_RS21065	COG0180	Tryptophanyl-tRNA synthetase
SH04_RS21070	COG0546	phosphoglycolate phosphatase activity
SH04_RS21075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SH04_RS21080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SH04_RS21085	COG3266	domain, Protein
SH04_RS21100	COG4796	Type ii and iii secretion system protein
SH04_RS21115	COG3166	PFAM Fimbrial assembly family protein
SH04_RS21120	COG4972	Pilus assembly protein
SH04_RS21125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SH04_RS21130	COG0494	nUDIX hydrolase
SH04_RS21140	COG1011	Hydrolase
SH04_RS21145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SH04_RS21155	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SH04_RS21180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SH04_RS21185	COG2183	response to ionizing radiation
SH04_RS21190	COG1918	ferrous iron import across plasma membrane
SH04_RS21195	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SH04_RS21205	COG5464	transposase or invertase
SH04_RS21215	COG1040	competence protein
SH04_RS21225	COG2610	gluconate transmembrane transporter activity
SH04_RS21230	COG1640	4-alpha-glucanotransferase
SH04_RS21235	COG0058	SHG alpha-glucan phosphorylase activity
SH04_RS21250	COG1690	Belongs to the RtcB family
SH04_RS21255	COG4650	regulator
SH04_RS21260	COG1349	DNA-binding transcription factor activity
SH04_RS21275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SH04_RS21280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SH04_RS21285	COG0058	SHG alpha-glucan phosphorylase activity
SH04_RS21310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SH04_RS21315	COG2095	MarC family integral membrane protein
SH04_RS21320	COG2610	gluconate transmembrane transporter activity
SH04_RS21325	COG3265	gluconokinase activity
SH04_RS21330	COG1609	Transcriptional regulator
SH04_RS21335	COG1741	Belongs to the pirin family
SH04_RS21340	COG0673	inositol 2-dehydrogenase activity
SH04_RS21345	COG1247	-acetyltransferase
SH04_RS21350	COG3157	Type VI secretion system effector, Hcp
SH04_RS21370	COG0405	Gamma-glutamyltransferase
SH04_RS21380	COG0584	glycerophosphoryl diester phosphodiesterase
SH04_RS21385	COG3842	ATPase activity
SH04_RS21390	COG0395	ABC-type sugar transport system, permease component
SH04_RS21395	COG1175	transmembrane transport
SH04_RS21400	COG1653	transport
SH04_RS21410	COG0410	ABC transporter
SH04_RS21415	COG0411	ABC transporter
SH04_RS21420	COG4177	L-phenylalanine transmembrane transporter activity
SH04_RS21425	COG0559	Belongs to the binding-protein-dependent transport system permease family
SH04_RS21430	COG0683	leucine binding
SH04_RS21435	COG0456	acetyltransferase
SH04_RS21445	COG0683	leucine binding
SH04_RS21450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SH04_RS21455	COG2177	Part of the ABC transporter FtsEX involved in
SH04_RS21460	COG2884	Cell division ATP-binding protein ftsE
SH04_RS21465	COG0552	protein localization to endoplasmic reticulum
SH04_RS21470	COG0742	ribosomal rna small subunit methyltransferase
SH04_RS21475	COG3776	membrane
SH04_RS21485	COG3714	YhhN family
SH04_RS21490	COG2217	Heavy metal translocating P-type atpase
SH04_RS21500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SH04_RS21510	COG0477	Major facilitator Superfamily
SH04_RS21515	COG0628	permease
SH04_RS21520	COG2091	lysine biosynthetic process via aminoadipic acid
SH04_RS21525	COG0747	negative chemotaxis
SH04_RS21530	COG0601	transmembrane transport
SH04_RS21535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH04_RS21540	COG0444	Belongs to the ABC transporter superfamily
SH04_RS21545	COG1124	(ABC) transporter
SH04_RS21555	COG3209	COG3209 Rhs family protein
SH04_RS21570	COG5433	transposase activity
SH04_RS21575	COG0842	Transport permease protein
SH04_RS21580	COG0842	Transport permease protein
SH04_RS21580	COG1129	ABC transporter
SH04_RS21585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS21615	COG2081	HI0933 family
SH04_RS21620	COG0306	phosphate transporter
SH04_RS21630	COG0589	response to stress
SH04_RS21635	COG3104	oligopeptide transport
SH04_RS21645	COG0339	signal peptide processing
SH04_RS21650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SH04_RS21655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SH04_RS21670	COG0640	Transcriptional regulator
SH04_RS21675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SH04_RS21680	COG1393	Belongs to the ArsC family
SH04_RS21700	COG3065	identical protein binding
SH04_RS21705	COG2197	response regulator
SH04_RS21710	COG1285	pathogenesis
SH04_RS21725	COG3247	response to pH
SH04_RS21730	COG2771	luxR family
SH04_RS21740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SH04_RS21745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SH04_RS21750	COG2207	Transcriptional regulator
SH04_RS21755	COG2207	Transcriptional regulator
SH04_RS21760	COG0076	glutamate decarboxylase activity
SH04_RS21765	COG1858	cytochrome C peroxidase
SH04_RS21775	COG2197	response regulator
SH04_RS21780	COG0583	DNA-binding transcription factor activity
SH04_RS21785	COG1295	ribonuclease BN
SH04_RS21790	COG0477	Major facilitator Superfamily
SH04_RS21795	COG2982	Protein involved in outer membrane biogenesis
SH04_RS21800	COG2200	EAL domain
SH04_RS21810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SH04_RS21815	COG0612	Peptidase, M16
SH04_RS21825	COG2199	diguanylate cyclase activity
SH04_RS21825	COG2200	EAL domain
SH04_RS21830	COG0457	Tetratricopeptide repeat
SH04_RS21830	COG3118	belongs to the thioredoxin family
SH04_RS21835	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SH04_RS21840	COG1215	transferase activity, transferring glycosyl groups
SH04_RS21845	COG1215	transferase activity, transferring glycosyl groups
SH04_RS21875	COG2194	sulfuric ester hydrolase activity
SH04_RS21890	COG0814	amino acid
SH04_RS21895	COG4608	Belongs to the ABC transporter superfamily
SH04_RS21900	COG0444	Belongs to the ABC transporter superfamily
SH04_RS21905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SH04_RS21910	COG0601	transmembrane transport
SH04_RS21920	COG0747	negative chemotaxis
SH04_RS21935	COG2194	sulfuric ester hydrolase activity
SH04_RS21940	COG2223	nitrite transmembrane transporter activity
SH04_RS21945	COG5571	outer membrane autotransporter
SH04_RS21950	COG2818	Glycosylase
SH04_RS21955	COG0456	acetyltransferase
SH04_RS21960	COG0243	molybdopterin cofactor binding
SH04_RS21965	COG2885	chlorophyll binding
SH04_RS21980	COG2944	sequence-specific DNA binding
SH04_RS21985	COG1278	Cold shock
SH04_RS21995	COG2963	transposase activity
SH04_RS22000	COG2801	Transposase and inactivated derivatives
SH04_RS22020	COG3274	enterobacterial common antigen metabolic process
SH04_RS22025	COG4682	membrane
SH04_RS22030	COG4682	membrane
SH04_RS22035	COG1070	Carbohydrate kinase
SH04_RS22045	COG4213	ABC transporter substrate-binding protein
SH04_RS22055	COG4213	ABC transporter substrate-binding protein
SH04_RS22060	COG1129	ABC transporter
SH04_RS22065	COG4214	carbohydrate transport
SH04_RS22070	COG1609	Transcriptional regulator
SH04_RS22070	COG2207	Transcriptional regulator
SH04_RS22075	COG2992	FlgJ-related protein
SH04_RS22080	COG0366	Alpha amylase catalytic
SH04_RS22085	COG3977	Valine--pyruvate aminotransferase
SH04_RS22095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SH04_RS22100	COG1414	Transcriptional regulator
SH04_RS22110	COG2731	YhcH YjgK YiaL family protein
SH04_RS22115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SH04_RS22120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SH04_RS22125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SH04_RS22130	COG1070	Carbohydrate kinase
SH04_RS22135	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SH04_RS22140	COG3623	hexulose-6-phosphate isomerase
SH04_RS22145	COG0235	Class ii aldolase
SH04_RS22150	COG3713	MltA-interacting MipA family protein
SH04_RS22155	COG0583	DNA-binding transcription factor activity
SH04_RS22160	COG1566	PFAM secretion protein HlyD family protein
SH04_RS22175	COG1012	belongs to the aldehyde dehydrogenase family
SH04_RS22180	COG1454	alcohol dehydrogenase
SH04_RS22185	COG3276	selenocysteine insertion sequence binding
SH04_RS22195	COG0625	glutathione transferase activity
SH04_RS22200	COG3209	COG3209 Rhs family protein
SH04_RS22205	COG1413	lyase activity
SH04_RS22210	COG3209	COG3209 Rhs family protein
SH04_RS22215	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SH04_RS22225	COG1566	PFAM secretion protein HlyD family protein
SH04_RS22245	COG3722	fumarate hydratase activity
SH04_RS22260	COG1620	l-lactate permease
SH04_RS22265	COG2186	Transcriptional regulator
SH04_RS22275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SH04_RS22280	COG1045	serine acetyltransferase
SH04_RS22295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SH04_RS22300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SH04_RS22310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SH04_RS22315	COG4942	peptidase
SH04_RS22320	COG2861	carbohydrate metabolic process
SH04_RS22325	COG1216	Glycosyl transferase, family 2
SH04_RS22335	COG0156	8-amino-7-oxononanoate synthase activity
SH04_RS22350	COG0859	PFAM glycosyl transferase family 9
SH04_RS22355	COG0859	PFAM glycosyl transferase family 9
SH04_RS22360	COG3307	-O-antigen
SH04_RS22365	COG0859	PFAM glycosyl transferase family 9
SH04_RS22375	COG3642	lipopolysaccharide core region biosynthetic process
SH04_RS22380	COG1442	glycosyl transferase family 8
SH04_RS22385	COG1442	glycosyl transferase family 8
SH04_RS22390	COG0438	transferase activity, transferring glycosyl groups
SH04_RS22395	COG4641	Protein conserved in bacteria
SH04_RS22395	COG0438	transferase activity, transferring glycosyl groups
SH04_RS22400	COG0515	serine threonine protein kinase
SH04_RS22405	COG0438	transferase activity, transferring glycosyl groups
SH04_RS22410	COG0859	PFAM glycosyl transferase family 9
SH04_RS22415	COG1519	Transferase
SH04_RS22445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SH04_RS22450	COG0756	dUTP diphosphatase activity
SH04_RS22470	COG1561	YicC-like family, N-terminal region
SH04_RS22475	COG3645	SOS response
SH04_RS22480	COG2860	membrane
SH04_RS22490	COG0194	GDP metabolic process
SH04_RS22500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SH04_RS22505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SH04_RS22510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SH04_RS22515	COG0786	glutamate:sodium symporter activity
SH04_RS22520	COG2233	PERMEase
SH04_RS22525	COG2982	Protein involved in outer membrane biogenesis
SH04_RS22530	COG1501	Belongs to the glycosyl hydrolase 31 family
SH04_RS22535	COG2211	Major facilitator Superfamily
SH04_RS22550	COG2814	Major facilitator Superfamily
SH04_RS22555	COG0697	spore germination
SH04_RS22560	COG1464	Belongs to the NlpA lipoprotein family
SH04_RS22585	COG2252	PERMEase
SH04_RS22595	COG2271	Major facilitator Superfamily
SH04_RS22600	COG2271	Major facilitator Superfamily
SH04_RS22605	COG3851	Histidine kinase
SH04_RS22610	COG2197	response regulator
SH04_RS22615	COG0440	acetolactate synthase activity
SH04_RS22620	COG0028	Belongs to the TPP enzyme family
SH04_RS22645	COG2814	Major facilitator Superfamily
SH04_RS22650	COG0641	radical SAM
SH04_RS22660	COG2149	membrane
SH04_RS22670	COG3119	arylsulfatase activity
SH04_RS22675	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SH04_RS22680	COG2207	Transcriptional regulator
SH04_RS22690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SH04_RS22690	COG1263	PTS System
SH04_RS22695	COG1263	PTS System
SH04_RS22700	COG2188	Transcriptional regulator
SH04_RS22720	COG5645	(Lipo)protein
SH04_RS22725	COG0823	Involved in the tonB-independent uptake of proteins
SH04_RS22730	COG0644	oxidoreductase
SH04_RS22735	COG2271	Major facilitator Superfamily
SH04_RS22745	COG0800	Aldolase
SH04_RS22750	COG3734	2-keto-3-deoxy-galactonokinase
SH04_RS22755	COG2186	Transcriptional regulator
SH04_RS22765	COG0561	phosphatase activity
SH04_RS22770	COG3753	Protein conserved in bacteria
SH04_RS22780	COG0187	DNA topoisomerase II activity
SH04_RS22790	COG0592	DNA-directed DNA polymerase activity
SH04_RS22875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction