locus-tag	class	description
U068_RS00010	COG0527	aspartate kinase activity
U068_RS00010	COG0460	homoserine dehydrogenase
U068_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U068_RS00040	COG1115	amino acid carrier protein
U068_RS00045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U068_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
U068_RS00055	COG1584	GPR1 FUN34 yaaH family protein
U068_RS00060	COG4735	regulation of single-species biofilm formation
U068_RS00080	COG3385	transposase activity
U068_RS00090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
U068_RS00095	COG0583	DNA-binding transcription factor activity
U068_RS00120	COG0196	riboflavin kinase activity
U068_RS00135	COG1047	Peptidyl-prolyl cis-trans
U068_RS00165	COG0505	Belongs to the CarA family
U068_RS00170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U068_RS00225	COG0644	oxidoreductase
U068_RS00230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
U068_RS00235	COG2271	Major facilitator Superfamily
U068_RS00250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U068_RS00275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U068_RS00280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U068_RS00285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
U068_RS00295	COG0564	pseudouridine synthase activity
U068_RS00305	COG0417	DNA replication proofreading
U068_RS00310	COG0235	Class ii aldolase
U068_RS00315	COG2160	L-arabinose isomerase activity
U068_RS00320	COG1069	ribulokinase activity
U068_RS00330	COG0586	Pfam SNARE associated Golgi protein
U068_RS00335	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
U068_RS00340	COG1178	ABC-type Fe3 transport system permease component
U068_RS00345	COG4143	(ABC) transporter
U068_RS00350	COG4533	DNA binding
U068_RS00360	COG2814	Major facilitator Superfamily
U068_RS00375	COG0473	3-isopropylmalate dehydrogenase activity
U068_RS00390	COG0583	DNA-binding transcription factor activity
U068_RS00395	COG0028	Belongs to the TPP enzyme family
U068_RS00400	COG0440	acetolactate synthase activity
U068_RS00410	COG1609	Transcriptional regulator
U068_RS00415	COG2001	Belongs to the MraZ family
U068_RS00425	COG3116	cell division
U068_RS00430	COG0768	penicillin binding
U068_RS00435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U068_RS00440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U068_RS00450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U068_RS00455	COG0772	Belongs to the SEDS family
U068_RS00470	COG1181	Belongs to the D-alanine--D-alanine ligase family
U068_RS00475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
U068_RS00480	COG0849	cell division
U068_RS00485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U068_RS00505	COG0494	nUDIX hydrolase
U068_RS00525	COG0237	dephospho-CoA kinase activity
U068_RS00535	COG1459	type II secretion system
U068_RS00540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U068_RS00545	COG4969	Belongs to the N-Me-Phe pilin family
U068_RS00555	COG0157	Belongs to the NadC ModD family
U068_RS00560	COG3023	N-Acetylmuramoyl-L-alanine amidase
U068_RS00565	COG3725	Membrane protein required for beta-lactamase induction
U068_RS00570	COG1113	amino acid transport
U068_RS00575	COG2186	Transcriptional regulator
U068_RS00580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
U068_RS00585	COG0508	dehydrogenase complex catalyzes the overall conversion of
U068_RS00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U068_RS00595	COG3064	Membrane
U068_RS00600	COG1049	propionate catabolic process, 2-methylcitrate cycle
U068_RS00625	COG2132	Multicopper oxidase
U068_RS00630	COG4993	Dehydrogenase
U068_RS00635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
U068_RS00640	COG0288	reversible hydration of carbon dioxide
U068_RS00645	COG1131	(ABC) transporter
U068_RS00650	COG0842	Transport permease protein
U068_RS00655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS00660	COG0726	polysaccharide deacetylase
U068_RS00670	COG5464	transposase or invertase
U068_RS00685	COG3539	Fimbrial protein
U068_RS00690	COG3539	Fimbrial protein
U068_RS00695	COG3539	Fimbrial protein
U068_RS00700	COG3539	Fimbrial protein
U068_RS00705	COG3188	usher protein
U068_RS00710	COG3121	Chaperone
U068_RS00715	COG3539	Fimbrial protein
U068_RS00720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
U068_RS00725	COG0617	tRNA 3'-terminal CCA addition
U068_RS00735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U068_RS00745	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
U068_RS00750	COG1643	Atp-dependent helicase
U068_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U068_RS00765	COG4774	siderophore transport
U068_RS00770	COG1120	ATPase activity
U068_RS00775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U068_RS00780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U068_RS00800	COG2860	membrane
U068_RS00805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U068_RS00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U068_RS00825	COG3835	regulator
U068_RS00835	COG1408	metallophosphoesterase
U068_RS00850	COG0024	Methionine aminopeptidase
U068_RS00875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
U068_RS00880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
U068_RS00885	COG0575	Belongs to the CDS family
U068_RS00890	COG0750	zinc metalloprotease
U068_RS00900	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
U068_RS00905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
U068_RS00930	COG0587	DNA-directed DNA polymerase activity
U068_RS00940	COG1982	Orn Lys Arg decarboxylase major
U068_RS00945	COG0346	lactoylglutathione lyase activity
U068_RS00950	COG0037	tRNA processing
U068_RS00955	COG4568	rho-dependent transcription termination
U068_RS00965	COG4681	YaeQ
U068_RS00970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U068_RS00975	COG3015	lipoprotein NlpE involved in copper resistance
U068_RS00980	COG0791	NLP P60 protein
U068_RS00990	COG1720	tRNA m6t6A37 methyltransferase activity
U068_RS01000	COG1464	Belongs to the NlpA lipoprotein family
U068_RS01005	COG2011	ABC-type metal ion transport system permease component
U068_RS01010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U068_RS01015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U068_RS01045	COG0656	L-ascorbic acid biosynthetic process
U068_RS01050	COG0583	DNA-binding transcription factor activity
U068_RS01060	COG2226	methyltransferase
U068_RS01065	COG0741	lytic transglycosylase activity
U068_RS01065	COG1388	LysM domain
U068_RS01075	COG2226	methyltransferase
U068_RS01085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U068_RS01105	COG4104	PAAR repeat-containing protein
U068_RS01110	COG5433	transposase activity
U068_RS01115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U068_RS01125	COG1960	acyl-CoA dehydrogenase activity
U068_RS01135	COG0121	glutamine amidotransferase
U068_RS01140	COG3034	peptidoglycan biosynthetic process
U068_RS01145	COG3041	Addiction module toxin RelE StbE family
U068_RS01150	COG3077	Addiction module antitoxin, RelB DinJ family
U068_RS01155	COG0791	NLP P60 protein
U068_RS01160	COG1943	Transposase
U068_RS01180	COG2161	toxin-antitoxin pair type II binding
U068_RS01190	COG0454	-acetyltransferase
U068_RS01195	COG1690	Belongs to the RtcB family
U068_RS01200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U068_RS01205	COG2195	Cleaves the N-terminal amino acid of tripeptides
U068_RS01225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
U068_RS01255	COG2003	Belongs to the UPF0758 family
U068_RS01275	COG2378	regulation of single-species biofilm formation
U068_RS01290	COG3596	GTP binding
U068_RS01295	COG0583	DNA-binding transcription factor activity
U068_RS01300	COG2963	transposase activity
U068_RS01305	COG2826	transposase and inactivated derivatives, IS30 family
U068_RS01310	COG2801	Transposase and inactivated derivatives
U068_RS01325	COG3344	reverse transcriptase
U068_RS01335	COG0833	amino acid
U068_RS01340	COG2040	homocysteine
U068_RS01345	COG3842	ATPase activity
U068_RS01350	COG1178	ABC-type Fe3 transport system permease component
U068_RS01355	COG1662	PFAM IS1 transposase
U068_RS01360	COG1662	PFAM IS1 transposase
U068_RS01360	COG3677	Transposase
U068_RS01365	COG2963	transposase activity
U068_RS01375	COG3415	Transposase
U068_RS01375	COG2801	Transposase and inactivated derivatives
U068_RS01380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U068_RS01385	COG0129	dihydroxy-acid dehydratase activity
U068_RS01390	COG2211	Major facilitator Superfamily
U068_RS01395	COG3507	Belongs to the glycosyl hydrolase 43 family
U068_RS01400	COG1414	Transcriptional regulator
U068_RS01405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U068_RS01410	COG1662	PFAM IS1 transposase
U068_RS01415	COG1061	Type III restriction enzyme res subunit
U068_RS01425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U068_RS01445	COG0582	viral genome integration into host DNA
U068_RS01455	COG0583	DNA-binding transcription factor activity
U068_RS01460	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U068_RS01465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U068_RS01470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U068_RS01475	COG2080	2 iron, 2 sulfur cluster binding
U068_RS01480	COG3477	response to acidic pH
U068_RS01485	COG0727	PFAM Uncharacterised protein family (UPF0153)
U068_RS01490	COG3121	Chaperone
U068_RS01500	COG3188	usher protein
U068_RS01540	COG1388	LysM domain
U068_RS01550	COG2801	Transposase and inactivated derivatives
U068_RS01555	COG2207	Transcriptional regulator
U068_RS01555	COG3708	Transcriptional regulator
U068_RS01560	COG3059	membrane
U068_RS01570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U068_RS01575	COG2207	Transcriptional regulator
U068_RS01580	COG0247	lactate metabolic process
U068_RS01585	COG1139	Iron-sulfur cluster binding protein
U068_RS01590	COG1556	Lactate utilization protein
U068_RS01620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
U068_RS01630	COG2200	EAL domain
U068_RS01630	COG2771	luxR family
U068_RS01635	COG0583	DNA-binding transcription factor activity
U068_RS01645	COG0666	response to abiotic stimulus
U068_RS01655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U068_RS01660	COG1304	FMN binding
U068_RS01670	COG0549	Belongs to the carbamate kinase family
U068_RS01675	COG0402	S-adenosylhomocysteine deaminase activity
U068_RS01680	COG1064	alcohol dehydrogenase
U068_RS01695	COG1280	lysine exporter protein (LysE YggA)
U068_RS01705	COG3829	transcription factor binding
U068_RS01710	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
U068_RS01715	COG0372	Belongs to the citrate synthase family
U068_RS01720	COG2079	MmgE PrpD family protein
U068_RS01725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U068_RS01730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
U068_RS01735	COG0402	S-adenosylhomocysteine deaminase activity
U068_RS01740	COG0583	DNA-binding transcription factor activity
U068_RS01745	COG0288	reversible hydration of carbon dioxide
U068_RS01755	COG2807	transmembrane transport
U068_RS01760	COG0110	maltose O-acetyltransferase activity
U068_RS01765	COG2223	nitrite transmembrane transporter activity
U068_RS01770	COG3250	beta-galactosidase activity
U068_RS01775	COG1609	Transcriptional regulator
U068_RS01780	COG1414	Transcriptional regulator
U068_RS01800	COG3971	2-oxopent-4-enoate hydratase activity
U068_RS01815	COG2814	Major facilitator Superfamily
U068_RS01820	COG3122	Protein conserved in bacteria
U068_RS01830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
U068_RS01865	COG1215	transferase activity, transferring glycosyl groups
U068_RS01870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U068_RS01875	COG4521	taurine ABC transporter
U068_RS01885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U068_RS01890	COG2175	clavaminate synthase activity
U068_RS01895	COG0113	porphobilinogen synthase activity
U068_RS01905	COG2801	Transposase and inactivated derivatives
U068_RS01915	COG3468	outer membrane autotransporter barrel domain protein
U068_RS01920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U068_RS01925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U068_RS01935	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
U068_RS01955	COG1181	Belongs to the D-alanine--D-alanine ligase family
U068_RS01970	COG1785	Belongs to the alkaline phosphatase family
U068_RS01980	COG3706	GGDEF domain
U068_RS01985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U068_RS02010	COG4126	flavin adenine dinucleotide binding
U068_RS02030	COG1940	carbohydrate kinase activity
U068_RS02035	COG2814	Major facilitator Superfamily
U068_RS02040	COG0419	ATPase involved in DNA repair
U068_RS02045	COG0420	3'-5' exonuclease activity
U068_RS02050	COG0745	RESPONSE REGULATOR receiver
U068_RS02055	COG5002	protein histidine kinase activity
U068_RS02060	COG1114	Component of the transport system for branched-chain amino acids
U068_RS02065	COG1113	amino acid transport
U068_RS02070	COG0366	Alpha amylase catalytic
U068_RS02090	COG1862	Preprotein translocase
U068_RS02095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U068_RS02100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U068_RS02105	COG1403	HNH endonuclease
U068_RS02115	COG3248	Nucleoside-binding outer membrane protein
U068_RS02120	COG4238	major outer membrane lipoprotein
U068_RS02130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U068_RS02130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U068_RS02145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
U068_RS02150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U068_RS02155	COG0667	Aldo Keto reductase
U068_RS02165	COG0142	geranyltranstransferase activity
U068_RS02180	COG0693	protein deglycase activity
U068_RS02185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U068_RS02195	COG2814	Major facilitator Superfamily
U068_RS02205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U068_RS02210	COG1845	cytochrome c oxidase, subunit III
U068_RS02215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U068_RS02220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U068_RS02225	COG2223	nitrite transmembrane transporter activity
U068_RS02230	COG3056	Lipoprotein
U068_RS02235	COG0271	Belongs to the BolA IbaG family
U068_RS02260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U068_RS02265	COG0776	regulation of translation
U068_RS02270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U068_RS02275	COG1555	photosystem II stabilization
U068_RS02280	COG0824	Thioesterase
U068_RS02290	COG4533	DNA binding
U068_RS02300	COG1522	sequence-specific DNA binding
U068_RS02305	COG1132	(ABC) transporter
U068_RS02310	COG1132	(ABC) transporter
U068_RS02315	COG0347	Belongs to the P(II) protein family
U068_RS02320	COG0004	ammonium transporteR
U068_RS02325	COG1946	Acyl-CoA thioesterase
U068_RS02330	COG3126	Type III secretion system lipoprotein chaperone (YscW)
U068_RS02335	COG3695	enzyme binding
U068_RS02345	COG5507	3-demethylubiquinone-9 3-methyltransferase
U068_RS02350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
U068_RS02360	COG0110	maltose O-acetyltransferase activity
U068_RS02375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U068_RS02380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS02385	COG1309	transcriptional regulator
U068_RS02390	COG1196	nuclear chromosome segregation
U068_RS02390	COG3264	Mechanosensitive ion channel
U068_RS02405	COG3923	Primosomal replication protein n
U068_RS02410	COG2832	Protein of unknown function (DUF454)
U068_RS02420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
U068_RS02455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS02460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U068_RS02460	COG4651	solute:proton antiporter activity
U068_RS02465	COG2223	nitrite transmembrane transporter activity
U068_RS02470	COG0737	Belongs to the 5'-nucleotidase family
U068_RS02475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U068_RS02480	COG3735	TraB family
U068_RS02485	COG3093	addiction module antidote protein HigA
U068_RS02490	COG2217	Heavy metal translocating P-type atpase
U068_RS02495	COG2066	Belongs to the glutaminase family
U068_RS02500	COG0531	amino acid
U068_RS02505	COG0789	Transcriptional regulator
U068_RS02510	COG1585	Membrane protein implicated in regulation of membrane protease activity
U068_RS02515	COG0330	HflC and HflK could
U068_RS02520	COG4619	ABC transporter
U068_RS02525	COG0390	transport system, permease component
U068_RS02530	COG3118	belongs to the thioredoxin family
U068_RS02535	COG0300	oxidoreductase activity
U068_RS02540	COG2755	lipolytic protein G-D-S-L family
U068_RS02545	COG4181	ATPase activity
U068_RS02550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
U068_RS02555	COG3209	COG3209 Rhs family protein
U068_RS02565	COG3209	COG3209 Rhs family protein
U068_RS02575	COG2801	Transposase and inactivated derivatives
U068_RS02585	COG0583	DNA-binding transcription factor activity
U068_RS02595	COG1414	Transcriptional regulator
U068_RS02600	COG3960	tartronate-semialdehyde synthase activity
U068_RS02605	COG3622	Belongs to the hyi family
U068_RS02610	COG2084	Dehydrogenase
U068_RS02615	COG1953	Uracil, thiamine, allantoin
U068_RS02625	COG2233	PERMEase
U068_RS02630	COG1929	Belongs to the glycerate kinase type-1 family
U068_RS02635	COG3257	ureidoglycine aminohydrolase activity
U068_RS02640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U068_RS02645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
U068_RS02650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U068_RS02655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U068_RS02665	COG0549	Belongs to the carbamate kinase family
U068_RS02670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
U068_RS02675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
U068_RS02685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U068_RS02695	COG1988	membrane-bound metal-dependent
U068_RS02700	COG2501	S4 domain
U068_RS02710	COG3539	Fimbrial protein
U068_RS02715	COG3121	Chaperone
U068_RS02720	COG3188	usher protein
U068_RS02725	COG3539	Fimbrial protein
U068_RS02730	COG3539	Fimbrial protein
U068_RS02735	COG2197	response regulator
U068_RS02745	COG0582	viral genome integration into host DNA
U068_RS02770	COG2801	Transposase and inactivated derivatives
U068_RS02780	COG2076	Multidrug Resistance protein
U068_RS02790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U068_RS02795	COG1881	PFAM PEBP family protein
U068_RS02800	COG2207	Transcriptional regulator
U068_RS02840	COG3039	Transposase
U068_RS02855	COG3772	lysozyme
U068_RS02875	COG5562	phage envelope protein
U068_RS02895	COG4220	transposase activity
U068_RS02905	COG0500	methyltransferase
U068_RS02915	COG2207	Transcriptional regulator
U068_RS02920	COG4571	Outer membrane protease
U068_RS02930	COG2207	Transcriptional regulator
U068_RS02940	COG4783	chaperone-mediated protein folding
U068_RS02945	COG1215	transferase activity, transferring glycosyl groups
U068_RS02950	COG5002	protein histidine kinase activity
U068_RS02955	COG0745	RESPONSE REGULATOR receiver
U068_RS02960	COG1538	Outer membrane efflux protein
U068_RS02965	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS02970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS02975	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U068_RS02980	COG1113	amino acid transport
U068_RS02985	COG0668	transmembrane transport
U068_RS02990	COG0778	Nitroreductase
U068_RS02995	COG2315	Protein conserved in bacteria
U068_RS03020	COG3385	transposase activity
U068_RS03025	COG2977	Belongs to the P-Pant transferase superfamily
U068_RS03030	COG4771	TonB-dependent receptor
U068_RS03035	COG2382	esterase
U068_RS03040	COG3251	PFAM MbtH domain protein
U068_RS03045	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
U068_RS03045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U068_RS03050	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
U068_RS03055	COG1120	ATPase activity
U068_RS03060	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U068_RS03065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U068_RS03075	COG4592	Periplasmic binding protein
U068_RS03080	COG1169	isochorismate synthase
U068_RS03085	COG1021	2,3-dihydroxybenzoate-AMP ligase
U068_RS03090	COG3433	isochorismatase activity
U068_RS03090	COG1535	isochorismatase
U068_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS03100	COG2050	protein possibly involved in aromatic compounds catabolism
U068_RS03105	COG1966	Carbon starvation protein
U068_RS03110	COG2879	small protein
U068_RS03115	COG0371	Dehydrogenase
U068_RS03120	COG0436	Aminotransferase
U068_RS03125	COG1475	DNA binding
U068_RS03130	COG3969	phosphoadenosine phosphosulfate
U068_RS03135	COG0583	DNA-binding transcription factor activity
U068_RS03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U068_RS03145	COG0450	alkyl hydroperoxide reductase
U068_RS03150	COG3634	alkyl hydroperoxide reductase activity
U068_RS03155	COG0589	response to stress
U068_RS03160	COG1063	alcohol dehydrogenase
U068_RS03170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U068_RS03175	COG3719	Belongs to the RNase T2 family
U068_RS03180	COG0471	metal ion transport
U068_RS03195	COG3051	citrate lyase alpha subunit
U068_RS03200	COG2301	Belongs to the HpcH HpaI aldolase family
U068_RS03210	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
U068_RS03215	COG3290	protein histidine kinase activity
U068_RS03220	COG4565	transcriptional regulatory protein
U068_RS03225	COG3069	C4-dicarboxylate transmembrane transporter activity
U068_RS03250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U068_RS03260	COG0583	DNA-binding transcription factor activity
U068_RS03280	COG1686	Belongs to the peptidase S11 family
U068_RS03285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U068_RS03290	COG0772	Belongs to the SEDS family
U068_RS03295	COG0768	penicillin binding
U068_RS03305	COG0799	negative regulation of ribosome biogenesis
U068_RS03310	COG0406	alpha-ribazole phosphatase activity
U068_RS03320	COG1466	dna polymerase III delta subunit
U068_RS03335	COG2888	peptidyl-tyrosine sulfation
U068_RS03340	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U068_RS03350	COG2214	Heat shock protein DnaJ domain protein
U068_RS03355	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U068_RS03365	COG2214	Heat shock protein DnaJ domain protein
U068_RS03370	COG0443	Heat shock 70 kDa protein
U068_RS03380	COG1126	abc transporter atp-binding protein
U068_RS03385	COG0765	amino acid transport
U068_RS03390	COG0765	amino acid transport
U068_RS03395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS03405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
U068_RS03410	COG4535	Mg2 and Co2 transporter CorC
U068_RS03420	COG1702	phosphate starvation-inducible protein PhoH
U068_RS03430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U068_RS03470	COG0367	asparagine synthase
U068_RS03475	COG0647	UMP catabolic process
U068_RS03480	COG1846	Transcriptional regulator
U068_RS03480	COG1940	carbohydrate kinase activity
U068_RS03485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U068_RS03495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS03495	COG2190	(PTS) system
U068_RS03495	COG1263	PTS System
U068_RS03515	COG0735	belongs to the Fur family
U068_RS03530	COG0716	FMN binding
U068_RS03540	COG0596	Alpha beta hydrolase
U068_RS03545	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
U068_RS03550	COG0033	Phosphoglucomutase
U068_RS03570	COG0531	amino acid
U068_RS03575	COG1982	Orn Lys Arg decarboxylase major
U068_RS03585	COG0745	RESPONSE REGULATOR receiver
U068_RS03590	COG2205	protein histidine kinase activity
U068_RS03620	COG3209	COG3209 Rhs family protein
U068_RS03630	COG3209	COG3209 Rhs family protein
U068_RS03640	COG5433	transposase activity
U068_RS03645	COG5433	transposase activity
U068_RS03655	COG5433	transposase activity
U068_RS03660	COG3272	Protein of unknown function (DUF1722)
U068_RS03665	COG0415	Belongs to the DNA photolyase family
U068_RS03670	COG3104	oligopeptide transport
U068_RS03675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U068_RS03680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
U068_RS03685	COG1984	allophanate hydrolase subunit 2
U068_RS03700	COG3180	Ammonia monooxygenase
U068_RS03705	COG3539	Fimbrial protein
U068_RS03710	COG3121	Chaperone
U068_RS03715	COG3188	usher protein
U068_RS03720	COG3539	Fimbrial protein
U068_RS03725	COG0372	Belongs to the citrate synthase family
U068_RS03735	COG2009	succinate dehydrogenase
U068_RS03740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
U068_RS03745	COG1053	succinate dehydrogenase
U068_RS03750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U068_RS03760	COG0567	Dehydrogenase, E1 component
U068_RS03765	COG0508	dehydrogenase complex catalyzes the overall conversion of
U068_RS03775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U068_RS03780	COG2188	Transcriptional regulator
U068_RS03785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS03785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS03785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS03790	COG0383	alpha-mannosidase activity
U068_RS03800	COG1271	oxidase subunit
U068_RS03805	COG1294	oxidase, subunit
U068_RS03810	COG4890	Cyd operon protein YbgT
U068_RS03815	COG3790	cyd operon protein YbgE
U068_RS03820	COG0824	Thioesterase
U068_RS03825	COG0811	peptide transport
U068_RS03830	COG0848	biopolymer transport protein
U068_RS03835	COG3064	Membrane
U068_RS03845	COG2885	chlorophyll binding
U068_RS03850	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
U068_RS03920	COG3201	nicotinamide mononucleotide transporter
U068_RS03925	COG1230	cation diffusion facilitator family transporter
U068_RS03940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U068_RS03950	COG2017	converts alpha-aldose to the beta-anomer
U068_RS03960	COG1085	galactose-1-phosphate uridylyltransferase
U068_RS03965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U068_RS03970	COG1119	ATPase activity
U068_RS03975	COG3585	molybdate ion transport
U068_RS03975	COG2005	Transcriptional regulator
U068_RS03985	COG0725	ABC transporter, periplasmic molybdate-binding protein
U068_RS03990	COG4149	molybdate abc transporter
U068_RS03995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
U068_RS04000	COG0561	phosphatase activity
U068_RS04010	COG0583	DNA-binding transcription factor activity
U068_RS04015	COG2828	Protein conserved in bacteria
U068_RS04020	COG0471	metal ion transport
U068_RS04025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
U068_RS04030	COG4677	pectinesterase activity
U068_RS04035	COG1881	PFAM PEBP family protein
U068_RS04040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U068_RS04055	COG2226	methyltransferase
U068_RS04060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U068_RS04070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
U068_RS04080	COG0521	Mo-molybdopterin cofactor biosynthetic process
U068_RS04090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
U068_RS04095	COG0314	molybdopterin synthase activity
U068_RS04100	COG0670	Belongs to the BI1 family
U068_RS04105	COG0670	Belongs to the BI1 family
U068_RS04110	COG0392	lysyltransferase activity
U068_RS04115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U068_RS04120	COG3568	Endonuclease Exonuclease Phosphatase
U068_RS04130	COG0842	Transport permease protein
U068_RS04135	COG0842	Transport permease protein
U068_RS04140	COG1131	(ABC) transporter
U068_RS04150	COG1309	transcriptional regulator
U068_RS04155	COG0513	Belongs to the DEAD box helicase family
U068_RS04160	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
U068_RS04165	COG1199	ATP-dependent helicase activity
U068_RS04170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U068_RS04175	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
U068_RS04185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U068_RS04195	COG4774	siderophore transport
U068_RS04210	COG0668	transmembrane transport
U068_RS04215	COG1126	abc transporter atp-binding protein
U068_RS04220	COG0765	amino acid transport
U068_RS04225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS04240	COG5006	permease, DMT superfamily
U068_RS04245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
U068_RS04250	COG2194	sulfuric ester hydrolase activity
U068_RS04260	COG1321	iron dependent repressor
U068_RS04265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U068_RS04270	COG1376	ErfK ybiS ycfS ynhG family protein
U068_RS04275	COG0488	(ABC) transporter
U068_RS04285	COG0561	phosphatase activity
U068_RS04290	COG1882	Formate acetyltransferase
U068_RS04295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U068_RS04300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U068_RS04305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U068_RS04310	COG0303	'Molybdopterin
U068_RS04315	COG1446	asparaginase
U068_RS04320	COG4172	Belongs to the ABC transporter superfamily
U068_RS04325	COG0747	negative chemotaxis
U068_RS04335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U068_RS04340	COG2200	EAL domain
U068_RS04345	COG2199	diguanylate cyclase activity
U068_RS04360	COG2133	pyrroloquinoline quinone binding
U068_RS04365	COG0625	glutathione transferase activity
U068_RS04370	COG1686	Belongs to the peptidase S11 family
U068_RS04375	COG1349	DNA-binding transcription factor activity
U068_RS04380	COG0671	phosphoesterase, PA-phosphatase related
U068_RS04385	COG2814	Major facilitator Superfamily
U068_RS04395	COG0561	phosphatase activity
U068_RS04400	COG0738	Major facilitator superfamily
U068_RS04405	COG3226	Transcriptional regulator
U068_RS04420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U068_RS04430	COG0778	Nitroreductase
U068_RS04450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
U068_RS04455	COG3842	ATPase activity
U068_RS04460	COG1176	ABC-type spermidine putrescine transport system, permease component I
U068_RS04465	COG1177	transmembrane transport
U068_RS04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS04485	COG4160	amino acid transport
U068_RS04490	COG4215	(ABC) transporter
U068_RS04495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS04500	COG1126	abc transporter atp-binding protein
U068_RS04515	COG3023	N-Acetylmuramoyl-L-alanine amidase
U068_RS04520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U068_RS04525	COG0702	epimerase
U068_RS04530	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
U068_RS04535	COG0028	Belongs to the TPP enzyme family
U068_RS04540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U068_RS04550	COG2431	L-lysine efflux transmembrane transporter activity
U068_RS04565	COG3593	DNA synthesis involved in DNA repair
U068_RS04570	COG2990	Protein conserved in bacteria
U068_RS04575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS04580	COG0577	efflux transmembrane transporter activity
U068_RS04580	COG1136	(ABC) transporter
U068_RS04585	COG1278	Cold shock
U068_RS04595	COG0542	response to heat
U068_RS04615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
U068_RS04620	COG4988	ABC transporter
U068_RS04625	COG0492	ferredoxin-NADP+ reductase activity
U068_RS04630	COG1522	sequence-specific DNA binding
U068_RS04635	COG1674	ftsk spoiiie
U068_RS04635	COG1178	ABC-type Fe3 transport system permease component
U068_RS04645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U068_RS04655	COG0243	molybdopterin cofactor binding
U068_RS04660	COG0437	4 iron, 4 sulfur cluster binding
U068_RS04665	COG3302	dmso reductase anchor subunit
U068_RS04670	COG1335	isochorismatase
U068_RS04680	COG0531	amino acid
U068_RS04685	COG0583	DNA-binding transcription factor activity
U068_RS04690	COG2249	NAD(P)H dehydrogenase (quinone) activity
U068_RS04695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U068_RS04700	COG1882	Formate acetyltransferase
U068_RS04705	COG2116	formate transmembrane transporter activity
U068_RS04710	COG1944	ATP diphosphatase activity
U068_RS04715	COG2323	membrane
U068_RS04730	COG0501	Belongs to the peptidase M48B family
U068_RS04740	COG0539	negative regulation of cytoplasmic translation
U068_RS04750	COG0658	competence protein
U068_RS04750	COG2333	competence protein COMEC
U068_RS04755	COG1132	(ABC) transporter
U068_RS04765	COG3214	Protein conserved in bacteria
U068_RS04780	COG3173	Aminoglycoside phosphotransferase
U068_RS04785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
U068_RS04790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U068_RS04800	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
U068_RS04810	COG2989	Protein conserved in bacteria
U068_RS04815	COG3108	Peptidase M15
U068_RS04820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U068_RS04825	COG1448	Aminotransferase
U068_RS04850	COG0308	aminopeptidase N
U068_RS04855	COG1116	anion transmembrane transporter activity
U068_RS04860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U068_RS04870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U068_RS04875	COG0431	NADPH-dependent FMN reductase
U068_RS04880	COG3539	Fimbrial protein
U068_RS04885	COG3121	Chaperone
U068_RS04890	COG3188	usher protein
U068_RS04895	COG3539	Fimbrial protein
U068_RS04900	COG3539	Fimbrial protein
U068_RS04905	COG3539	Fimbrial protein
U068_RS04910	COG3121	Chaperone
U068_RS04925	COG0633	Ferredoxin
U068_RS04925	COG3217	Mosc domain protein beta barrel domain protein
U068_RS04935	COG0488	(ABC) transporter
U068_RS04940	COG2995	paraquat-inducible protein a
U068_RS04945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U068_RS04945	COG3008	intermembrane lipid transfer
U068_RS04950	COG3009	Protein conserved in bacteria
U068_RS04955	COG3130	regulation of translation
U068_RS04965	COG1067	ATP-dependent peptidase activity
U068_RS04975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
U068_RS04975	COG2885	chlorophyll binding
U068_RS04990	COG3070	regulator of competence-specific genes
U068_RS04995	COG1289	transmembrane transporter activity
U068_RS05000	COG3304	Inner membrane component domain
U068_RS05005	COG0210	DNA helicase
U068_RS05025	COG1832	CoA-binding protein
U068_RS05040	COG1254	Belongs to the acylphosphatase family
U068_RS05045	COG2920	part of a sulfur-relay system
U068_RS05050	COG0670	Belongs to the BI1 family
U068_RS05060	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
U068_RS05065	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
U068_RS05070	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
U068_RS05075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U068_RS05080	COG1999	signal sequence binding
U068_RS05085	COG1773	rubredoxin
U068_RS05090	COG1271	oxidase subunit
U068_RS05095	COG1294	oxidase, subunit
U068_RS05110	COG0489	protein tyrosine kinase activity
U068_RS05110	COG3206	protein involved in exopolysaccharide biosynthesis
U068_RS05115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U068_RS05120	COG1596	polysaccharide export
U068_RS05125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U068_RS05150	COG1662	PFAM IS1 transposase
U068_RS05155	COG1278	Cold shock
U068_RS05160	COG1278	Cold shock
U068_RS05175	COG0348	domain, Protein
U068_RS05180	COG2205	protein histidine kinase activity
U068_RS05180	COG2198	Histidine kinase
U068_RS05180	COG0784	Response regulator, receiver
U068_RS05185	COG1879	ABC-type sugar transport system periplasmic component
U068_RS05190	COG0745	RESPONSE REGULATOR receiver
U068_RS05195	COG3005	denitrification pathway
U068_RS05200	COG0243	molybdopterin cofactor binding
U068_RS05245	COG3729	General stress protein
U068_RS05250	COG2233	PERMEase
U068_RS05285	COG1309	transcriptional regulator
U068_RS05290	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U068_RS05290	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U068_RS05290	COG0506	proline dehydrogenase activity
U068_RS05300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U068_RS05315	COG2822	iron ion transport
U068_RS05320	COG2837	iron assimilation
U068_RS05330	COG1702	phosphate starvation-inducible protein PhoH
U068_RS05335	COG3658	cytochrome
U068_RS05340	COG1215	transferase activity, transferring glycosyl groups
U068_RS05345	COG1649	PFAM Uncharacterised BCR, COG1649
U068_RS05345	COG0726	polysaccharide deacetylase
U068_RS05350	COG0457	Tetratricopeptide repeat
U068_RS05360	COG2801	Transposase and inactivated derivatives
U068_RS05400	COG3381	protein complex oligomerization
U068_RS05410	COG1462	curli production assembly transport component CsgG
U068_RS05425	COG2197	response regulator
U068_RS05455	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
U068_RS05460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U068_RS05485	COG2943	transferase activity, transferring hexosyl groups
U068_RS05490	COG5645	(Lipo)protein
U068_RS05510	COG1560	Kdo2-lipid A biosynthetic process
U068_RS05520	COG2353	YceI-like domain
U068_RS05525	COG3038	cytochrome b561
U068_RS05560	COG2999	glutathione oxidoreductase activity
U068_RS05570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U068_RS05580	COG0673	inositol 2-dehydrogenase activity
U068_RS05585	COG0728	peptidoglycan biosynthetic process
U068_RS05590	COG3418	PFAM FlgN family protein
U068_RS05595	COG2747	anti-sigma28 factor FlgM
U068_RS05600	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
U068_RS05605	COG1815	bacterial-type flagellum-dependent cell motility
U068_RS05610	COG1558	bacterial-type flagellum-dependent cell motility
U068_RS05615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
U068_RS05620	COG1749	Flagellar hook protein flgE
U068_RS05625	COG4787	bacterial-type flagellum-dependent cell motility
U068_RS05630	COG4786	Flagellar basal body rod
U068_RS05645	COG1705	Flagellar rod assembly protein muramidase FlgJ
U068_RS05645	COG3951	Flagellar rod assembly protein muramidase FlgJ
U068_RS05650	COG1256	bacterial-type flagellum assembly
U068_RS05655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U068_RS05660	COG1530	ribonuclease E activity
U068_RS05670	COG0564	pseudouridine synthase activity
U068_RS05675	COG0424	maF-like protein
U068_RS05680	COG1399	metal-binding, possibly nucleic acid-binding protein
U068_RS05700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U068_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS05715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U068_RS05720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U068_RS05725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U068_RS05735	COG0470	DNA polymerase III
U068_RS05740	COG0084	hydrolase, TatD family'
U068_RS05745	COG1263	PTS System
U068_RS05745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS05750	COG4773	Receptor
U068_RS05755	COG0537	adenosine 5'-monophosphoramidase activity
U068_RS05760	COG5633	Lipoprotein
U068_RS05765	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
U068_RS05785	COG1252	NADH dehydrogenase
U068_RS05790	COG3134	Outer membrane lipoprotein
U068_RS05795	COG1309	transcriptional regulator
U068_RS05805	COG1376	ErfK ybiS ycfS ynhG family protein
U068_RS05805	COG1388	LysM domain
U068_RS05810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U068_RS05815	COG4763	Acyl-transferase
U068_RS05820	COG4591	ABC-type transport system involved in lipoprotein release permease component
U068_RS05825	COG1136	(ABC) transporter
U068_RS05830	COG4591	ABC-type transport system involved in lipoprotein release permease component
U068_RS05840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U068_RS05845	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
U068_RS05855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
U068_RS05860	COG1177	transmembrane transport
U068_RS05870	COG3842	ATPase activity
U068_RS05885	COG2850	peptidyl-arginine hydroxylation
U068_RS05890	COG2205	protein histidine kinase activity
U068_RS05895	COG0745	RESPONSE REGULATOR receiver
U068_RS05900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U068_RS05920	COG1187	pseudouridine synthase activity
U068_RS05925	COG0538	isocitrate dehydrogenase activity
U068_RS05940	COG5562	phage envelope protein
U068_RS05945	COG0789	Transcriptional regulator
U068_RS05950	COG2200	EAL domain
U068_RS05975	COG2200	EAL domain
U068_RS06020	COG2894	cell division
U068_RS06050	COG0179	Fumarylacetoacetate (FAA) hydrolase
U068_RS06065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U068_RS06070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U068_RS06075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
U068_RS06090	COG2719	SpoVR family
U068_RS06100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U068_RS06110	COG1619	proteins homologs of microcin C7 resistance protein MccF
U068_RS06120	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
U068_RS06125	COG2261	transglycosylase associated protein
U068_RS06140	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
U068_RS06140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U068_RS06140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS06145	COG1461	Dihydroxyacetone kinase
U068_RS06150	COG2376	Dihydroxyacetone kinase
U068_RS06155	COG3284	Transcriptional regulator
U068_RS06160	COG3468	outer membrane autotransporter barrel domain protein
U068_RS06170	COG0012	GTP binding
U068_RS06185	COG0659	secondary active sulfate transmembrane transporter activity
U068_RS06190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U068_RS06215	COG2890	protein-(glutamine-N5) methyltransferase activity
U068_RS06220	COG3094	Invasion gene expression up-regulator, SirB
U068_RS06225	COG2912	Transglutaminase-like superfamily
U068_RS06245	COG0387	Pfam Sodium calcium exchanger
U068_RS06250	COG4572	Cation transport regulator
U068_RS06255	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
U068_RS06260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
U068_RS06265	COG4932	domain protein
U068_RS06270	COG2197	response regulator
U068_RS06275	COG3850	Histidine kinase
U068_RS06285	COG2223	nitrite transmembrane transporter activity
U068_RS06290	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
U068_RS06295	COG1140	nitrate reductase beta subunit
U068_RS06300	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
U068_RS06305	COG2181	nitrate reductase activity
U068_RS06340	COG0788	formyltetrahydrofolate deformylase activity
U068_RS06350	COG1752	Esterase of the alpha-beta hydrolase superfamily
U068_RS06355	COG0745	RESPONSE REGULATOR receiver
U068_RS06360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U068_RS06370	COG1435	thymidine kinase activity
U068_RS06385	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS06385	COG1454	alcohol dehydrogenase
U068_RS06390	COG2095	MarC family integral membrane protein
U068_RS06395	COG4166	transmembrane transport
U068_RS06400	COG0601	transmembrane transport
U068_RS06405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U068_RS06410	COG0444	Belongs to the ABC transporter superfamily
U068_RS06415	COG4608	Belongs to the ABC transporter superfamily
U068_RS06435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U068_RS06440	COG2350	Protein conserved in bacteria
U068_RS06445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
U068_RS06450	COG1607	acyl-coa hydrolase
U068_RS06465	COG3047	cAMP biosynthetic process
U068_RS06470	COG3685	Protein conserved in bacteria
U068_RS06475	COG3685	Protein conserved in bacteria
U068_RS06480	COG3729	General stress protein
U068_RS06495	COG0135	phosphoribosylanthranilate isomerase activity
U068_RS06495	COG0134	indole-3-glycerol-phosphate synthase activity
U068_RS06500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U068_RS06500	COG0512	Glutamine amidotransferase of anthranilate synthase
U068_RS06505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U068_RS06510	COG0613	PHP domain protein
U068_RS06515	COG0009	L-threonylcarbamoyladenylate synthase
U068_RS06520	COG4907	membrane protein (DUF2207)
U068_RS06525	COG1187	pseudouridine synthase activity
U068_RS06530	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
U068_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS06545	COG0616	signal peptide processing
U068_RS06560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U068_RS06565	COG0583	DNA-binding transcription factor activity
U068_RS06585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
U068_RS06595	COG0671	phosphoesterase, PA-phosphatase related
U068_RS06600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
U068_RS06605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
U068_RS06615	COG0023	Translation Initiation Factor
U068_RS06625	COG1349	DNA-binding transcription factor activity
U068_RS06635	COG5001	Diguanylate cyclase
U068_RS06650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U068_RS06650	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U068_RS06655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U068_RS06660	COG2852	Protein conserved in bacteria
U068_RS06665	COG4172	Belongs to the ABC transporter superfamily
U068_RS06670	COG4172	Belongs to the ABC transporter superfamily
U068_RS06675	COG4171	peptide transport system, permease
U068_RS06680	COG4168	peptide transport system, permease
U068_RS06685	COG4166	transmembrane transport
U068_RS06700	COG0531	amino acid
U068_RS06705	COG0174	glutamine synthetase
U068_RS06710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
U068_RS06715	COG1396	sequence-specific DNA binding
U068_RS06715	COG1917	Cupin 2, conserved barrel domain protein
U068_RS06720	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS06725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U068_RS06730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
U068_RS06735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U068_RS06740	COG1842	Phage shock protein A
U068_RS06750	COG1983	PspC domain protein
U068_RS06760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U068_RS06765	COG0366	Alpha amylase catalytic
U068_RS06770	COG1653	transport
U068_RS06775	COG1175	transmembrane transport
U068_RS06780	COG0395	ABC-type sugar transport system, permease component
U068_RS06785	COG1063	alcohol dehydrogenase
U068_RS06790	COG1082	Xylose isomerase domain protein TIM barrel
U068_RS06795	COG0673	inositol 2-dehydrogenase activity
U068_RS06800	COG1554	hydrolase, family 65, central catalytic
U068_RS06805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U068_RS06820	COG1609	Transcriptional regulator
U068_RS06825	COG3106	COG3106 Predicted ATPase
U068_RS06835	COG3283	Transcriptional regulator of aromatic amino acids metabolism
U068_RS06840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
U068_RS06845	COG4948	Mandelate Racemase Muconate Lactonizing
U068_RS06850	COG2866	Carboxypeptidase
U068_RS06855	COG0702	epimerase
U068_RS06860	COG1073	alpha beta
U068_RS06865	COG0583	DNA-binding transcription factor activity
U068_RS06875	COG4166	transmembrane transport
U068_RS06880	COG0668	transmembrane transport
U068_RS06890	COG3182	Iron-regulated membrane protein
U068_RS06895	COG0589	response to stress
U068_RS06900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U068_RS06905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U068_RS06910	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
U068_RS06920	COG1473	amidohydrolase
U068_RS06925	COG1473	amidohydrolase
U068_RS06930	COG0583	DNA-binding transcription factor activity
U068_RS06940	COG2840	Smr protein MutS2
U068_RS06945	COG3706	GGDEF domain
U068_RS06960	COG0513	Belongs to the DEAD box helicase family
U068_RS06970	COG0582	viral genome integration into host DNA
U068_RS06990	COG3723	Recombinational DNA repair protein, rece pathway
U068_RS06995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U068_RS07030	COG4197	protein conserved in bacteria, prophage-related
U068_RS07040	COG3756	Protein conserved in bacteria
U068_RS07045	COG1484	DNA-dependent DNA replication
U068_RS07050	COG1846	Transcriptional regulator
U068_RS07060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U068_RS07065	COG1475	DNA binding
U068_RS07080	COG1196	nuclear chromosome segregation
U068_RS07090	COG3039	Transposase
U068_RS07110	COG5301	cellulose 1,4-beta-cellobiosidase activity
U068_RS07115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
U068_RS07120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U068_RS07130	COG0589	response to stress
U068_RS07135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
U068_RS07140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U068_RS07140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
U068_RS07140	COG1013	pyruvate-flavodoxin oxidoreductase activity
U068_RS07140	COG0674	pyruvate-flavodoxin oxidoreductase activity
U068_RS07145	COG3042	response to heat
U068_RS07150	COG3187	Heat shock protein
U068_RS07155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U068_RS07160	COG2911	Protein conserved in bacteria
U068_RS07170	COG3784	Protein of unknown function (DUF1318)
U068_RS07175	COG2207	Transcriptional regulator
U068_RS07180	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS07185	COG3733	amine oxidase
U068_RS07190	COG2030	dehydratase
U068_RS07190	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS07195	COG3396	Phenylacetate-CoA oxygenase
U068_RS07200	COG3460	Phenylacetate-CoA oxygenase
U068_RS07205	COG3396	Phenylacetate-CoA oxygenase
U068_RS07210	COG2151	metal-sulfur cluster biosynthetic enzyme
U068_RS07215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U068_RS07220	COG1024	Enoyl-CoA hydratase
U068_RS07225	COG1024	Enoyl-CoA hydratase
U068_RS07230	COG1250	3-hydroxyacyl-CoA dehydrogenase
U068_RS07235	COG2050	protein possibly involved in aromatic compounds catabolism
U068_RS07240	COG0183	Belongs to the thiolase family
U068_RS07245	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
U068_RS07250	COG3327	negative regulation of DNA-templated transcription, initiation
U068_RS07255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U068_RS07275	COG2826	transposase and inactivated derivatives, IS30 family
U068_RS07285	COG0667	Aldo Keto reductase
U068_RS07295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U068_RS07300	COG4589	Belongs to the CDS family
U068_RS07305	COG2267	carboxylic ester hydrolase activity
U068_RS07310	COG0671	phosphoesterase, PA-phosphatase related
U068_RS07310	COG2453	phosphatase
U068_RS07320	COG1643	Atp-dependent helicase
U068_RS07325	COG1434	Gram-negative-bacterium-type cell wall biogenesis
U068_RS07330	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS07335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U068_RS07340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U068_RS07345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U068_RS07350	COG3038	cytochrome b561
U068_RS07365	COG0840	transmembrane signaling receptor activity
U068_RS07370	COG0583	DNA-binding transcription factor activity
U068_RS07375	COG5383	Protein conserved in bacteria
U068_RS07390	COG2841	Protein conserved in bacteria
U068_RS07395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U068_RS07400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U068_RS07405	COG1275	C4-dicarboxylate transporter malic acid transport protein
U068_RS07410	COG0500	methyltransferase
U068_RS07430	COG0675	Transposase, IS605 OrfB family
U068_RS07435	COG3135	benzoate transporter
U068_RS07440	COG1396	sequence-specific DNA binding
U068_RS07445	COG0826	peptidase U32
U068_RS07455	COG1724	mRNA binding
U068_RS07460	COG1598	PFAM Uncharacterised protein family UPF0150
U068_RS07465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U068_RS07470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
U068_RS07475	COG3842	ATPase activity
U068_RS07480	COG1176	ABC-type spermidine putrescine transport system, permease component I
U068_RS07485	COG1177	transmembrane transport
U068_RS07510	COG3238	Protein conserved in bacteria
U068_RS07515	COG1247	-acetyltransferase
U068_RS07520	COG2130	NADP-dependent
U068_RS07525	COG1802	Transcriptional regulator
U068_RS07530	COG4772	TonB-dependent receptor
U068_RS07535	COG3391	amine dehydrogenase activity
U068_RS07540	COG1113	amino acid transport
U068_RS07545	COG0625	glutathione transferase activity
U068_RS07555	COG3209	COG3209 Rhs family protein
U068_RS07565	COG5433	transposase activity
U068_RS07570	COG5433	transposase activity
U068_RS07580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
U068_RS07585	COG2162	N-hydroxyarylamine O-acetyltransferase activity
U068_RS07590	COG0384	phenazine biosynthesis protein PhzF
U068_RS07595	COG2181	nitrate reductase activity
U068_RS07600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
U068_RS07605	COG1140	nitrate reductase beta subunit
U068_RS07610	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
U068_RS07615	COG2223	nitrite transmembrane transporter activity
U068_RS07625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
U068_RS07630	COG0697	spore germination
U068_RS07635	COG0243	molybdopterin cofactor binding
U068_RS07635	COG3383	formate dehydrogenase (NAD+) activity
U068_RS07640	COG0243	molybdopterin cofactor binding
U068_RS07640	COG3383	formate dehydrogenase (NAD+) activity
U068_RS07645	COG0437	4 iron, 4 sulfur cluster binding
U068_RS07650	COG2864	formate dehydrogenase
U068_RS07655	COG3093	addiction module antidote protein HigA
U068_RS07660	COG1064	alcohol dehydrogenase
U068_RS07680	COG1764	response to oxidative stress
U068_RS07685	COG4608	Belongs to the ABC transporter superfamily
U068_RS07690	COG0444	Belongs to the ABC transporter superfamily
U068_RS07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U068_RS07700	COG0601	transmembrane transport
U068_RS07705	COG0747	negative chemotaxis
U068_RS07710	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
U068_RS07715	COG2202	Pas domain
U068_RS07715	COG2200	EAL domain
U068_RS07715	COG2199	diguanylate cyclase activity
U068_RS07720	COG3706	GGDEF domain
U068_RS07725	COG1649	PFAM Uncharacterised BCR, COG1649
U068_RS07730	COG0531	amino acid
U068_RS07735	COG0076	glutamate decarboxylase activity
U068_RS07745	COG0612	Peptidase, M16
U068_RS07750	COG4771	TonB-dependent receptor
U068_RS07755	COG4178	(ABC) transporter
U068_RS07760	COG0641	radical SAM
U068_RS07765	COG3119	arylsulfatase activity
U068_RS07770	COG2207	Transcriptional regulator
U068_RS07780	COG0243	molybdopterin cofactor binding
U068_RS07785	COG3539	Fimbrial protein
U068_RS07790	COG3539	Fimbrial protein
U068_RS07795	COG3539	Fimbrial protein
U068_RS07800	COG3188	usher protein
U068_RS07805	COG4977	sequence-specific DNA binding
U068_RS07810	COG3550	peptidyl-serine autophosphorylation
U068_RS07815	COG1396	sequence-specific DNA binding
U068_RS07825	COG3210	domain, Protein
U068_RS07825	COG2911	Protein conserved in bacteria
U068_RS07875	COG3781	membrane
U068_RS07890	COG2199	diguanylate cyclase activity
U068_RS07900	COG2066	Belongs to the glutaminase family
U068_RS07905	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS07910	COG0583	DNA-binding transcription factor activity
U068_RS07930	COG1846	Transcriptional regulator
U068_RS07935	COG4977	sequence-specific DNA binding
U068_RS07945	COG0697	spore germination
U068_RS07950	COG2814	Major facilitator Superfamily
U068_RS07960	COG3706	GGDEF domain
U068_RS07965	COG3111	PFAM Bacterial OB fold (BOF) protein
U068_RS07970	COG1546	Belongs to the CinA family
U068_RS07975	COG0339	signal peptide processing
U068_RS07980	COG4221	oxidoreductase activity
U068_RS07985	COG1802	Transcriptional regulator
U068_RS07995	COG0246	Mannitol dehydrogenase
U068_RS08000	COG0477	Major facilitator Superfamily
U068_RS08010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U068_RS08015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
U068_RS08020	COG5301	cellulose 1,4-beta-cellobiosidase activity
U068_RS08025	COG4220	transposase activity
U068_RS08035	COG5562	phage envelope protein
U068_RS08050	COG1278	Cold shock
U068_RS08060	COG3772	lysozyme
U068_RS08075	COG1278	Cold shock
U068_RS08080	COG1278	Cold shock
U068_RS08085	COG0484	heat shock protein binding
U068_RS08090	COG1403	HNH endonuclease
U068_RS08110	COG2026	Addiction module toxin, RelE StbE family
U068_RS08115	COG3077	Addiction module antitoxin, RelB DinJ family
U068_RS08140	COG1396	sequence-specific DNA binding
U068_RS08180	COG0582	viral genome integration into host DNA
U068_RS08185	COG1063	alcohol dehydrogenase
U068_RS08190	COG4948	Mandelate Racemase Muconate Lactonizing
U068_RS08205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U068_RS08220	COG0243	molybdopterin cofactor binding
U068_RS08225	COG0243	molybdopterin cofactor binding
U068_RS08230	COG0437	4 iron, 4 sulfur cluster binding
U068_RS08235	COG3302	dmso reductase anchor subunit
U068_RS08240	COG3381	protein complex oligomerization
U068_RS08250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U068_RS08255	COG1940	carbohydrate kinase activity
U068_RS08260	COG0583	DNA-binding transcription factor activity
U068_RS08265	COG2814	Major facilitator Superfamily
U068_RS08280	COG3591	Belongs to the peptidase S1B family
U068_RS08295	COG0628	permease
U068_RS08300	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
U068_RS08305	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
U068_RS08315	COG0531	amino acid
U068_RS08325	COG3136	membrane protein required for alginate biosynthesis
U068_RS08330	COG0745	RESPONSE REGULATOR receiver
U068_RS08335	COG2205	protein histidine kinase activity
U068_RS08345	COG0114	fumarate hydratase activity
U068_RS08350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
U068_RS08350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
U068_RS08355	COG1482	cell wall glycoprotein biosynthetic process
U068_RS08360	COG5339	Protein conserved in bacteria
U068_RS08370	COG2211	Major facilitator Superfamily
U068_RS08375	COG3250	beta-galactosidase activity
U068_RS08380	COG1309	transcriptional regulator
U068_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS08390	COG1609	Transcriptional regulator
U068_RS08395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS08395	COG1263	PTS System
U068_RS08400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U068_RS08410	COG0673	inositol 2-dehydrogenase activity
U068_RS08450	COG4659	FMN binding
U068_RS08460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U068_RS08470	COG3104	oligopeptide transport
U068_RS08475	COG0625	glutathione transferase activity
U068_RS08480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
U068_RS08495	COG3895	Periplasmic Protein
U068_RS08505	COG3133	Outer membrane lipoprotein
U068_RS08520	COG1566	PFAM secretion protein HlyD family protein
U068_RS08525	COG1289	transmembrane transporter activity
U068_RS08530	COG2032	superoxide dismutase activity
U068_RS08535	COG4989	oxidoreductase activity
U068_RS08540	COG3313	Fe-S protein
U068_RS08545	COG1309	transcriptional regulator
U068_RS08550	COG1902	pentaerythritol trinitrate reductase activity
U068_RS08555	COG0346	lactoylglutathione lyase activity
U068_RS08560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U068_RS08565	COG1201	RNA secondary structure unwinding
U068_RS08570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
U068_RS08575	COG0791	NLP P60 protein
U068_RS08580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U068_RS08585	COG2814	Major facilitator Superfamily
U068_RS08600	COG0583	DNA-binding transcription factor activity
U068_RS08605	COG2814	Major facilitator Superfamily
U068_RS08610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
U068_RS08615	COG0307	riboflavin synthase, alpha
U068_RS08625	COG3468	outer membrane autotransporter barrel domain protein
U068_RS08645	COG4529	Protein conserved in bacteria
U068_RS08655	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
U068_RS08660	COG0437	4 iron, 4 sulfur cluster binding
U068_RS08670	COG2414	aldehyde ferredoxin oxidoreductase
U068_RS08675	COG0437	4 iron, 4 sulfur cluster binding
U068_RS08685	COG0469	pyruvate kinase activity
U068_RS08690	COG4238	major outer membrane lipoprotein
U068_RS08695	COG1376	ErfK ybiS ycfS ynhG family protein
U068_RS08710	COG0719	Fe-S assembly protein
U068_RS08715	COG0396	ATPase activity
U068_RS08720	COG0719	Fe-S assembly protein
U068_RS08725	COG0316	Belongs to the HesB IscA family
U068_RS08735	COG2050	protein possibly involved in aromatic compounds catabolism
U068_RS08740	COG0277	FAD linked oxidase domain protein
U068_RS08740	COG0247	lactate metabolic process
U068_RS08745	COG0628	permease
U068_RS08760	COG0738	Major facilitator superfamily
U068_RS08765	COG2271	Major facilitator Superfamily
U068_RS08780	COG4670	ketone body catabolic process
U068_RS08785	COG1960	acyl-CoA dehydrogenase activity
U068_RS08790	COG1917	Cupin 2, conserved barrel domain protein
U068_RS08790	COG2207	Transcriptional regulator
U068_RS08800	COG2086	electron transfer activity
U068_RS08805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
U068_RS08810	COG0644	oxidoreductase
U068_RS08815	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
U068_RS08820	COG0318	PFAM AMP-dependent synthetase and ligase
U068_RS08825	COG0574	Belongs to the PEP-utilizing enzyme family
U068_RS08825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U068_RS08840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U068_RS08845	COG4256	Hemin uptake protein
U068_RS08855	COG2200	EAL domain
U068_RS08860	COG0791	NLP P60 protein
U068_RS08870	COG0386	Belongs to the glutathione peroxidase family
U068_RS08885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U068_RS08885	COG0072	phenylalanine-tRNA ligase activity
U068_RS08930	COG3137	Salt-induced outer membrane protein
U068_RS08935	COG1105	Belongs to the carbohydrate kinase PfkB family
U068_RS08945	COG3001	Fructosamine kinase
U068_RS08955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U068_RS08960	COG1988	membrane-bound metal-dependent
U068_RS08965	COG1823	symporter activity
U068_RS08980	COG0753	catalase activity
U068_RS08990	COG1486	melibiose metabolic process
U068_RS08995	COG2169	Transcriptional regulator
U068_RS08995	COG1917	Cupin 2, conserved barrel domain protein
U068_RS09000	COG1447	Phosphotransferase system cellobiose-specific component IIA
U068_RS09005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U068_RS09010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U068_RS09015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U068_RS09030	COG0322	excinuclease ABC activity
U068_RS09040	COG3678	ATP-independent chaperone mediated protein folding
U068_RS09070	COG0708	Exodeoxyribonuclease III
U068_RS09075	COG0398	Pfam SNARE associated Golgi protein
U068_RS09085	COG0398	Pfam SNARE associated Golgi protein
U068_RS09090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U068_RS09095	COG4134	Bacterial extracellular solute-binding protein
U068_RS09100	COG4135	transport system, permease component
U068_RS09105	COG4136	ATPase activity
U068_RS09110	COG2897	thiosulfate sulfurtransferase activity
U068_RS09115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U068_RS09120	COG0494	nUDIX hydrolase
U068_RS09130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U068_RS09140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U068_RS09155	COG0778	Nitroreductase
U068_RS09165	COG0616	signal peptide processing
U068_RS09170	COG0252	asparaginase activity
U068_RS09175	COG1335	isochorismatase
U068_RS09180	COG2814	Major facilitator Superfamily
U068_RS09185	COG1349	DNA-binding transcription factor activity
U068_RS09190	COG0667	Aldo Keto reductase
U068_RS09195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS09200	COG0191	fructose-bisphosphate aldolase activity
U068_RS09205	COG1063	alcohol dehydrogenase
U068_RS09210	COG2271	Major facilitator Superfamily
U068_RS09215	COG1063	alcohol dehydrogenase
U068_RS09220	COG3139	Protein of unknown function (DUF1315)
U068_RS09230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U068_RS09235	COG0676	glucose-6-phosphate 1-epimerase activity
U068_RS09240	COG0656	L-ascorbic acid biosynthetic process
U068_RS09245	COG3713	MltA-interacting MipA family protein
U068_RS09250	COG2766	serine protein kinase
U068_RS09260	COG2199	diguanylate cyclase activity
U068_RS09265	COG2199	diguanylate cyclase activity
U068_RS09270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U068_RS09285	COG2207	Transcriptional regulator
U068_RS09290	COG2807	transmembrane transport
U068_RS09295	COG3189	MarR family transcriptional regulator
U068_RS09300	COG3042	response to heat
U068_RS09305	COG2203	Gaf domain
U068_RS09305	COG2199	diguanylate cyclase activity
U068_RS09315	COG2261	transglycosylase associated protein
U068_RS09325	COG3615	Tellurite resistance protein tehB
U068_RS09335	COG0583	DNA-binding transcription factor activity
U068_RS09340	COG0473	3-isopropylmalate dehydrogenase activity
U068_RS09345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
U068_RS09350	COG4638	Rieske (2fe-2S)
U068_RS09355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U068_RS09360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
U068_RS09365	COG0318	PFAM AMP-dependent synthetase and ligase
U068_RS09370	COG3065	identical protein binding
U068_RS09375	COG1214	PFAM Peptidase M22, glycoprotease
U068_RS09380	COG1199	ATP-dependent helicase activity
U068_RS09385	COG0251	oxidation-reduction process
U068_RS09400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U068_RS09410	COG1760	l-serine dehydratase
U068_RS09415	COG2200	EAL domain
U068_RS09420	COG1253	flavin adenine dinucleotide binding
U068_RS09430	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS09430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS09435	COG3715	PTS system
U068_RS09440	COG3716	PTS system mannose fructose sorbose family IID component
U068_RS09460	COG2226	methyltransferase
U068_RS09495	COG1414	Transcriptional regulator
U068_RS09500	COG2814	Major facilitator Superfamily
U068_RS09510	COG0793	Belongs to the peptidase S41A family
U068_RS09520	COG1956	GAF domain-containing protein
U068_RS09525	COG2995	paraquat-inducible protein a
U068_RS09530	COG3008	intermembrane lipid transfer
U068_RS09550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U068_RS09565	COG1276	copper resistance
U068_RS09570	COG2372	response to copper ion
U068_RS09580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U068_RS09585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U068_RS09590	COG1770	oligopeptidase
U068_RS09595	COG2979	Protein of unknown function (DUF533)
U068_RS09610	COG3141	response to X-ray
U068_RS09620	COG0800	Aldolase
U068_RS09625	COG0129	dihydroxy-acid dehydratase activity
U068_RS09630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
U068_RS09640	COG1737	Transcriptional regulator
U068_RS09645	COG0469	pyruvate kinase activity
U068_RS09650	COG1560	Kdo2-lipid A biosynthetic process
U068_RS09655	COG0739	heme binding
U068_RS09660	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
U068_RS09670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U068_RS09695	COG0217	transcriptional regulatory protein
U068_RS09700	COG0494	nUDIX hydrolase
U068_RS09710	COG1335	isochorismatase
U068_RS09715	COG1801	Protein of unknown function DUF72
U068_RS09720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
U068_RS09735	COG0243	molybdopterin cofactor binding
U068_RS09740	COG3005	denitrification pathway
U068_RS09750	COG3102	Protein conserved in bacteria
U068_RS09760	COG3755	Protein conserved in bacteria
U068_RS09770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U068_RS09775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U068_RS09780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
U068_RS09785	COG0745	RESPONSE REGULATOR receiver
U068_RS09790	COG2201	protein-glutamate methylesterase activity
U068_RS09795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U068_RS09800	COG0840	transmembrane signaling receptor activity
U068_RS09805	COG0840	transmembrane signaling receptor activity
U068_RS09810	COG0835	chemotaxis
U068_RS09815	COG2198	Histidine kinase
U068_RS09815	COG0643	Histidine kinase
U068_RS09820	COG1360	Flagellar Motor Protein
U068_RS09825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U068_RS09840	COG0589	response to stress
U068_RS09850	COG1877	trehalose-phosphatase activity
U068_RS09855	COG1172	Belongs to the binding-protein-dependent transport system permease family
U068_RS09860	COG1129	ABC transporter
U068_RS09865	COG1879	ABC-type sugar transport system periplasmic component
U068_RS09870	COG1528	Iron-storage protein
U068_RS09890	COG1528	Iron-storage protein
U068_RS09900	COG0814	amino acid
U068_RS09905	COG3012	SEC-C Motif Domain Protein
U068_RS09905	COG3318	Belongs to the UPF0149 family
U068_RS09935	COG2197	response regulator
U068_RS09950	COG2197	response regulator
U068_RS09955	COG1126	abc transporter atp-binding protein
U068_RS09960	COG0765	amino acid transport
U068_RS09970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS09980	COG1191	sigma factor activity
U068_RS09985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U068_RS09990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
U068_RS09995	COG1516	flagellar protein fliS
U068_RS10005	COG0366	Alpha amylase catalytic
U068_RS10015	COG2391	methyltransferase activity
U068_RS10020	COG0425	Belongs to the sulfur carrier protein TusA family
U068_RS10025	COG2135	peptidase activity
U068_RS10030	COG0454	-acetyltransferase
U068_RS10055	COG1766	The M ring may be actively involved in energy transduction
U068_RS10060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U068_RS10065	COG1317	bacterial-type flagellum organization
U068_RS10070	COG1157	protein secretion by the type III secretion system
U068_RS10075	COG2882	bacterial-type flagellum organization
U068_RS10080	COG3144	bacterial-type flagellum assembly
U068_RS10085	COG1580	Controls the rotational direction of flagella during chemotaxis
U068_RS10090	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U068_RS10095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U068_RS10100	COG3190	flagellar
U068_RS10105	COG1338	Plays a role in the flagellum-specific transport system
U068_RS10110	COG1987	bacterial-type flagellum assembly
U068_RS10115	COG1684	flagellar biosynthetic protein fliR
U068_RS10120	COG2197	response regulator
U068_RS10140	COG3706	GGDEF domain
U068_RS10145	COG5475	Uncharacterized small protein (DUF2158)
U068_RS10150	COG2354	Protein conserved in bacteria
U068_RS10155	COG0697	spore germination
U068_RS10160	COG3727	T/G mismatch-specific endonuclease activity
U068_RS10165	COG0270	DNA (cytosine-5-)-methyltransferase activity
U068_RS10170	COG1418	mRNA catabolic process
U068_RS10195	COG2205	protein histidine kinase activity
U068_RS10200	COG0745	RESPONSE REGULATOR receiver
U068_RS10205	COG2351	hydroxyisourate hydrolase activity
U068_RS10220	COG3443	Belongs to the bacterial solute-binding protein 9 family
U068_RS10225	COG3038	cytochrome b561
U068_RS10250	COG1470	cell adhesion involved in biofilm formation
U068_RS10250	COG1388	LysM domain
U068_RS10260	COG0477	Major facilitator Superfamily
U068_RS10265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U068_RS10270	COG0217	transcriptional regulatory protein
U068_RS10280	COG0534	Mate efflux family protein
U068_RS10290	COG0583	DNA-binding transcription factor activity
U068_RS10295	COG0583	DNA-binding transcription factor activity
U068_RS10305	COG1376	ErfK ybiS ycfS ynhG family protein
U068_RS10320	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
U068_RS10325	COG3039	Transposase
U068_RS10345	COG4771	TonB-dependent receptor
U068_RS10355	COG3468	outer membrane autotransporter barrel domain protein
U068_RS10365	COG2003	Belongs to the UPF0758 family
U068_RS10405	COG1289	transmembrane transporter activity
U068_RS10415	COG1686	Belongs to the peptidase S11 family
U068_RS10420	COG2925	Exonuclease
U068_RS10425	COG0425	Belongs to the sulfur carrier protein TusA family
U068_RS10430	COG2391	methyltransferase activity
U068_RS10435	COG0531	amino acid
U068_RS10440	COG0583	DNA-binding transcription factor activity
U068_RS10445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U068_RS10450	COG4115	mRNA cleavage
U068_RS10455	COG2161	toxin-antitoxin pair type II binding
U068_RS10465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
U068_RS10475	COG0131	Imidazoleglycerol-phosphate dehydratase
U068_RS10475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
U068_RS10480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
U068_RS10495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
U068_RS10495	COG0140	phosphoribosyl-ATP diphosphatase activity
U068_RS10500	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
U068_RS10505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U068_RS10510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U068_RS10525	COG0438	transferase activity, transferring glycosyl groups
U068_RS10530	COG0110	maltose O-acetyltransferase activity
U068_RS10535	COG0438	transferase activity, transferring glycosyl groups
U068_RS10545	COG0562	UDP-galactopyranose mutase
U068_RS10550	COG2244	polysaccharide biosynthetic process
U068_RS10555	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
U068_RS10560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
U068_RS10570	COG1088	dTDP-glucose 4,6-dehydratase activity
U068_RS10575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U068_RS10585	COG0438	transferase activity, transferring glycosyl groups
U068_RS10590	COG2327	Polysaccharide pyruvyl transferase
U068_RS10595	COG2244	polysaccharide biosynthetic process
U068_RS10600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
U068_RS10605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U068_RS10610	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
U068_RS10610	COG0662	Cupin 2, conserved barrel domain protein
U068_RS10615	COG0297	glycogen (starch) synthase activity
U068_RS10620	COG1051	belongs to the nudix hydrolase family
U068_RS10625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U068_RS10630	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
U068_RS10635	COG0110	maltose O-acetyltransferase activity
U068_RS10640	COG1216	Glycosyl transferase, family 2
U068_RS10650	COG0438	transferase activity, transferring glycosyl groups
U068_RS10655	COG1045	serine acetyltransferase
U068_RS10660	COG0463	Glycosyl transferase, family 2
U068_RS10665	COG0489	protein tyrosine kinase activity
U068_RS10665	COG3206	protein involved in exopolysaccharide biosynthesis
U068_RS10670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U068_RS10675	COG1596	polysaccharide export
U068_RS10680	COG1253	flavin adenine dinucleotide binding
U068_RS10685	COG2982	Protein involved in outer membrane biogenesis
U068_RS10695	COG0572	uridine kinase
U068_RS10700	COG5002	protein histidine kinase activity
U068_RS10700	COG5001	Diguanylate cyclase
U068_RS10700	COG3447	MASE1 domain protein
U068_RS10705	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
U068_RS10715	COG0443	Heat shock 70 kDa protein
U068_RS10720	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
U068_RS10725	COG3779	Protein conserved in bacteria
U068_RS10730	COG0631	protein serine/threonine phosphatase activity
U068_RS10735	COG4245	von Willebrand factor, type A
U068_RS10760	COG2205	protein histidine kinase activity
U068_RS10765	COG0745	RESPONSE REGULATOR receiver
U068_RS10770	COG3422	double-strand break repair
U068_RS10775	COG0826	peptidase U32
U068_RS10805	COG2801	Transposase and inactivated derivatives
U068_RS10815	COG1063	alcohol dehydrogenase
U068_RS10820	COG3775	system Galactitol-specific IIC component
U068_RS10825	COG3414	Phosphotransferase system galactitol-specific IIB component
U068_RS10830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS10855	COG1830	Aldolase
U068_RS10860	COG2211	Major facilitator Superfamily
U068_RS10865	COG1397	ADP-ribosylglycohydrolase
U068_RS10870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS10875	COG2188	Transcriptional regulator
U068_RS10880	COG3757	hydrolase, family 25
U068_RS10885	COG0351	phosphomethylpyrimidine kinase
U068_RS10900	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
U068_RS10905	COG5455	response to cobalt ion
U068_RS10910	COG3539	Fimbrial protein
U068_RS10915	COG3188	usher protein
U068_RS10920	COG3121	Chaperone
U068_RS10925	COG3539	Fimbrial protein
U068_RS10940	COG0489	protein tyrosine kinase activity
U068_RS10960	COG3831	ATPase activity
U068_RS10970	COG0714	Associated with various cellular activities
U068_RS10975	COG2425	protein containing a von Willebrand factor type A (vWA) domain
U068_RS10980	COG3552	Protein containing von Willebrand factor type A (VWA) domain
U068_RS10985	COG4715	Zinc finger, swim domain protein
U068_RS10990	COG4808	Protein conserved in bacteria
U068_RS10995	COG4807	Protein conserved in bacteria
U068_RS11000	COG3279	Response regulator of the LytR AlgR family
U068_RS11005	COG3275	phosphorelay sensor kinase activity
U068_RS11010	COG0789	Transcriptional regulator
U068_RS11020	COG1174	glycine betaine transport
U068_RS11025	COG1125	glycine betaine transport
U068_RS11030	COG1174	glycine betaine transport
U068_RS11035	COG1732	Glycine betaine
U068_RS11040	COG1472	Belongs to the glycosyl hydrolase 3 family
U068_RS11045	COG0277	FAD linked oxidase domain protein
U068_RS11050	COG1686	Belongs to the peptidase S11 family
U068_RS11060	COG0586	Pfam SNARE associated Golgi protein
U068_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS11080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U068_RS11090	COG1346	cytolysis
U068_RS11100	COG2949	membrane
U068_RS11110	COG0493	'glutamate synthase
U068_RS11115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
U068_RS11115	COG0167	dihydroorotate dehydrogenase activity
U068_RS11120	COG4211	Belongs to the binding-protein-dependent transport system permease family
U068_RS11125	COG1129	ABC transporter
U068_RS11130	COG1879	ABC-type sugar transport system periplasmic component
U068_RS11135	COG1609	Transcriptional regulator
U068_RS11145	COG2311	Membrane
U068_RS11165	COG4771	TonB-dependent receptor
U068_RS11170	COG0833	amino acid
U068_RS11175	COG0583	DNA-binding transcription factor activity
U068_RS11180	COG2855	membrane
U068_RS11190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS11190	COG1522	sequence-specific DNA binding
U068_RS11195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U068_RS11205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U068_RS11210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U068_RS11215	COG2313	pseudouridylate synthase activity
U068_RS11220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS11225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
U068_RS11225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS11225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS11230	COG1105	Belongs to the carbohydrate kinase PfkB family
U068_RS11235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS11235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS11240	COG2814	Major facilitator Superfamily
U068_RS11255	COG0246	Mannitol dehydrogenase
U068_RS11260	COG0523	cobalamin synthesis protein
U068_RS11265	COG0671	phosphoesterase, PA-phosphatase related
U068_RS11270	COG0791	NLP P60 protein
U068_RS11275	COG2200	EAL domain
U068_RS11280	COG4166	transmembrane transport
U068_RS11285	COG4174	ABC transporter (Permease)
U068_RS11290	COG4239	(ABC) transporter, permease
U068_RS11295	COG4172	Belongs to the ABC transporter superfamily
U068_RS11305	COG2814	Major facilitator Superfamily
U068_RS11310	COG1187	pseudouridine synthase activity
U068_RS11315	COG1061	Type III restriction enzyme res subunit
U068_RS11335	COG3083	sulfuric ester hydrolase activity
U068_RS11345	COG3468	outer membrane autotransporter barrel domain protein
U068_RS11360	COG2197	response regulator
U068_RS11365	COG4235	cytochrome complex assembly
U068_RS11365	COG3088	subunit of a heme lyase
U068_RS11370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U068_RS11375	COG1138	Cytochrome C-type biogenesis protein
U068_RS11385	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U068_RS11390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U068_RS11395	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U068_RS11400	COG4133	protoheme IX ABC transporter activity
U068_RS11405	COG3005	denitrification pathway
U068_RS11410	COG3043	anaerobic respiration
U068_RS11415	COG0348	domain, Protein
U068_RS11420	COG0437	4 iron, 4 sulfur cluster binding
U068_RS11430	COG3062	negative regulation of establishment of protein localization
U068_RS11435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS11435	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS11455	COG4615	Cyclic peptide transporter
U068_RS11460	COG3145	DNA-N1-methyladenine dioxygenase activity
U068_RS11465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U068_RS11465	COG2169	Transcriptional regulator
U068_RS11470	COG1477	protein flavinylation
U068_RS11475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
U068_RS11490	COG2198	Histidine kinase
U068_RS11490	COG0642	Histidine kinase
U068_RS11495	COG2197	response regulator
U068_RS11500	COG0784	Response regulator, receiver
U068_RS11500	COG2205	protein histidine kinase activity
U068_RS11505	COG3852	Histidine kinase
U068_RS11510	COG2204	response regulator
U068_RS11515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
U068_RS11520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
U068_RS11525	COG2031	fatty acid transporter
U068_RS11530	COG0183	Belongs to the thiolase family
U068_RS11535	COG4676	Protein conserved in bacteria
U068_RS11540	COG5445	Predicted secreted protein (DUF2300)
U068_RS11545	COG2373	Large extracellular alpha-helical protein
U068_RS11555	COG3234	Protein of unknown function (DUF1175)
U068_RS11560	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
U068_RS11565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U068_RS11575	COG3468	outer membrane autotransporter barrel domain protein
U068_RS11585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U068_RS11590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U068_RS11595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U068_RS11600	COG3642	lipopolysaccharide core region biosynthetic process
U068_RS11605	COG0583	DNA-binding transcription factor activity
U068_RS11610	COG0584	glycerophosphoryl diester phosphodiesterase
U068_RS11615	COG2271	Major facilitator Superfamily
U068_RS11620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
U068_RS11630	COG0247	lactate metabolic process
U068_RS11635	COG5464	transposase or invertase
U068_RS11650	COG2271	Major facilitator Superfamily
U068_RS11660	COG1414	Transcriptional regulator
U068_RS11725	COG0318	PFAM AMP-dependent synthetase and ligase
U068_RS11735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
U068_RS11750	COG1169	isochorismate synthase
U068_RS11755	COG4575	ribosome binding
U068_RS11760	COG2153	protein acetylation
U068_RS11770	COG5160	protein modification by small protein removal
U068_RS11775	COG2304	oxidoreductase activity
U068_RS11780	COG2234	aminopeptidase activity
U068_RS11800	COG0457	Tetratricopeptide repeat
U068_RS11810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U068_RS11815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U068_RS11825	COG0839	Belongs to the complex I subunit 6 family
U068_RS11840	COG1034	ATP synthesis coupled electron transport
U068_RS11845	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
U068_RS11850	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
U068_RS11870	COG0583	DNA-binding transcription factor activity
U068_RS11875	COG0436	Aminotransferase
U068_RS11885	COG0471	metal ion transport
U068_RS11885	COG0490	domain, Protein
U068_RS11890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U068_RS11910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U068_RS11915	COG0280	phosphate acetyltransferase
U068_RS11915	COG0857	belongs to the CobB CobQ family
U068_RS11920	COG1288	antiporter activity
U068_RS11925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
U068_RS11930	COG0622	Phosphoesterase
U068_RS11935	COG0625	glutathione transferase activity
U068_RS11940	COG0625	glutathione transferase activity
U068_RS11945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U068_RS11950	COG1090	epimerase
U068_RS11955	COG5464	transposase or invertase
U068_RS11960	COG4598	ABC transporter
U068_RS11965	COG4160	amino acid transport
U068_RS11970	COG4215	(ABC) transporter
U068_RS11975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS11985	COG0163	prenyltransferase activity
U068_RS11990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
U068_RS11995	COG1286	toxin biosynthetic process
U068_RS12000	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
U068_RS12005	COG0285	dihydrofolate synthase activity
U068_RS12015	COG0586	Pfam SNARE associated Golgi protein
U068_RS12025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U068_RS12040	COG2814	Major facilitator Superfamily
U068_RS12045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U068_RS12060	COG3101	peptidyl-lysine hydroxylation
U068_RS12065	COG0730	response to heat
U068_RS12080	COG2890	protein-(glutamine-N5) methyltransferase activity
U068_RS12095	COG3539	Fimbrial protein
U068_RS12100	COG3539	Fimbrial protein
U068_RS12105	COG3539	Fimbrial protein
U068_RS12110	COG3121	Chaperone
U068_RS12120	COG3539	Fimbrial protein
U068_RS12125	COG2062	phosphohistidine phosphatase, SixA
U068_RS12140	COG3691	Protein conserved in bacteria
U068_RS12145	COG2067	long-chain fatty acid transport protein
U068_RS12155	COG2853	Lipoprotein
U068_RS12160	COG2116	formate transmembrane transporter activity
U068_RS12170	COG0582	viral genome integration into host DNA
U068_RS12175	COG2246	polysaccharide biosynthetic process
U068_RS12185	COG2801	Transposase and inactivated derivatives
U068_RS12190	COG0463	Glycosyl transferase, family 2
U068_RS12215	COG4725	Belongs to the MT-A70-like family
U068_RS12225	COG1846	Transcriptional regulator
U068_RS12235	COG5532	Uncharacterized conserved protein (DUF2303)
U068_RS12240	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
U068_RS12260	COG0583	DNA-binding transcription factor activity
U068_RS12265	COG2610	gluconate transmembrane transporter activity
U068_RS12275	COG0477	Major facilitator Superfamily
U068_RS12280	COG1566	PFAM secretion protein HlyD family protein
U068_RS12285	COG2197	response regulator
U068_RS12290	COG0784	Response regulator, receiver
U068_RS12290	COG2205	protein histidine kinase activity
U068_RS12290	COG2198	Histidine kinase
U068_RS12290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS12295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
U068_RS12300	COG0679	Auxin Efflux Carrier
U068_RS12305	COG0028	Belongs to the TPP enzyme family
U068_RS12335	COG1560	Kdo2-lipid A biosynthetic process
U068_RS12340	COG0436	Aminotransferase
U068_RS12345	COG3275	phosphorelay sensor kinase activity
U068_RS12350	COG3279	Response regulator of the LytR AlgR family
U068_RS12355	COG2207	Transcriptional regulator
U068_RS12360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS12360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U068_RS12360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS12365	COG1363	Peptidase, m42
U068_RS12370	COG0006	proline dipeptidase activity
U068_RS12375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS12380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS12410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U068_RS12415	COG3385	transposase activity
U068_RS12420	COG2199	diguanylate cyclase activity
U068_RS12420	COG2200	EAL domain
U068_RS12435	COG3415	Transposase
U068_RS12440	COG3415	Transposase
U068_RS12475	COG0583	DNA-binding transcription factor activity
U068_RS12485	COG2211	Major facilitator Superfamily
U068_RS12490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
U068_RS12500	COG0583	DNA-binding transcription factor activity
U068_RS12505	COG0385	Bile acid
U068_RS12510	COG3530	Putative quorum-sensing-regulated virulence factor
U068_RS12530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U068_RS12535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS12540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U068_RS12545	COG2190	(PTS) system
U068_RS12560	COG4884	unkown
U068_RS12560	COG3831	ATPase activity
U068_RS12565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U068_RS12570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
U068_RS12575	COG4208	sulfate ABC transporter
U068_RS12580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
U068_RS12585	COG4150	thiosulfate binding
U068_RS12590	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS12605	COG1263	PTS System
U068_RS12605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS12610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U068_RS12615	COG2837	iron assimilation
U068_RS12630	COG0456	acetyltransferase
U068_RS12635	COG0860	N-Acetylmuramoyl-L-alanine amidase
U068_RS12645	COG2207	Transcriptional regulator
U068_RS12650	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
U068_RS12655	COG4816	utilization protein
U068_RS12665	COG4303	Ethanolamine ammonia lyase large subunit
U068_RS12670	COG4819	ethanolamine utilization protein
U068_RS12675	COG3192	ethanolamine utilization protein
U068_RS12680	COG1454	alcohol dehydrogenase
U068_RS12685	COG4820	ethanolamine utilization protein (EutJ)
U068_RS12690	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS12695	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
U068_RS12700	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
U068_RS12705	COG0280	phosphate acetyltransferase
U068_RS12710	COG4812	Cobalamin adenosyltransferase
U068_RS12715	COG4766	ethanolamine catabolic process
U068_RS12720	COG4917	ethanolamine utilization protein
U068_RS12725	COG4810	utilization protein
U068_RS12730	COG0281	malic enzyme
U068_RS12730	COG0280	phosphate acetyltransferase
U068_RS12735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U068_RS12740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U068_RS12745	COG5342	invasion associated locus B
U068_RS12755	COG0493	'glutamate synthase
U068_RS12755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS12760	COG3850	Histidine kinase
U068_RS12765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U068_RS12775	COG1393	Belongs to the ArsC family
U068_RS12790	COG0400	carboxylic ester hydrolase activity
U068_RS12795	COG1444	tRNA N-acetyltransferase activity
U068_RS12800	COG2321	neutral zinc metallopeptidase
U068_RS12815	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
U068_RS12825	COG2716	regulation of RNA biosynthetic process
U068_RS12830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U068_RS12835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS12840	COG0651	ATP synthesis coupled electron transport
U068_RS12845	COG0650	Formate hydrogenlyase subunit 4
U068_RS12850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U068_RS12855	COG4237	Hydrogenase 4 membrane
U068_RS12860	COG0651	ATP synthesis coupled electron transport
U068_RS12865	COG3261	NADH dehydrogenase
U068_RS12865	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
U068_RS12870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U068_RS12875	COG3260	NADH ubiquinone oxidoreductase 20
U068_RS12885	COG3604	Transcriptional regulator
U068_RS12890	COG2116	formate transmembrane transporter activity
U068_RS12895	COG0628	permease
U068_RS12900	COG4783	chaperone-mediated protein folding
U068_RS12905	COG1393	Belongs to the ArsC family
U068_RS12915	COG2233	PERMEase
U068_RS12930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
U068_RS12935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
U068_RS12940	COG0248	Ppx GppA phosphatase
U068_RS12945	COG2200	EAL domain
U068_RS12960	COG3133	Outer membrane lipoprotein
U068_RS12975	COG0516	GMP reductase activity
U068_RS12975	COG0517	IMP dehydrogenase activity
U068_RS12985	COG1645	bacterial-type flagellum-dependent swarming motility
U068_RS12995	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U068_RS13000	COG2976	Protein conserved in bacteria
U068_RS13030	COG4953	penicillin-binding protein 1C
U068_RS13035	COG2373	Large extracellular alpha-helical protein
U068_RS13040	COG2897	thiosulfate sulfurtransferase activity
U068_RS13055	COG2975	iron-sulfur cluster assembly
U068_RS13060	COG0633	Ferredoxin
U068_RS13080	COG0822	iron-sulfur transferase activity
U068_RS13100	COG0483	inositol monophosphate 1-phosphatase activity
U068_RS13105	COG1073	alpha beta
U068_RS13110	COG3711	transcriptional antiterminator
U068_RS13115	COG2814	Major facilitator Superfamily
U068_RS13120	COG0583	DNA-binding transcription factor activity
U068_RS13125	COG4638	Rieske (2fe-2S)
U068_RS13150	COG2259	Doxx family
U068_RS13155	COG2017	converts alpha-aldose to the beta-anomer
U068_RS13160	COG1063	alcohol dehydrogenase
U068_RS13165	COG1172	Belongs to the binding-protein-dependent transport system permease family
U068_RS13170	COG1129	ABC transporter
U068_RS13175	COG1879	ABC-type sugar transport system periplasmic component
U068_RS13180	COG0457	Tetratricopeptide repeat
U068_RS13185	COG1940	carbohydrate kinase activity
U068_RS13195	COG1017	nitric oxide dioxygenase activity
U068_RS13195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U068_RS13200	COG0347	Belongs to the P(II) protein family
U068_RS13205	COG2204	response regulator
U068_RS13210	COG3170	Tfp pilus assembly protein FimV
U068_RS13215	COG2205	protein histidine kinase activity
U068_RS13220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U068_RS13220	COG0047	phosphoribosylformylglycinamidine synthase activity
U068_RS13235	COG0560	Phosphoserine phosphatase
U068_RS13240	COG1737	Transcriptional regulator
U068_RS13245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS13270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
U068_RS13290	COG0681	Belongs to the peptidase S26 family
U068_RS13300	COG3086	response to oxidative stress
U068_RS13305	COG3026	antisigma factor binding
U068_RS13310	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
U068_RS13315	COG1595	DNA-templated transcription, initiation
U068_RS13325	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
U068_RS13335	COG0513	Belongs to the DEAD box helicase family
U068_RS13345	COG0583	DNA-binding transcription factor activity
U068_RS13365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U068_RS13375	COG3118	belongs to the thioredoxin family
U068_RS13380	COG3148	PFAM DTW domain containing protein
U068_RS13385	COG0045	succinate-CoA ligase (ADP-forming) activity
U068_RS13385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U068_RS13385	COG1042	CoA-binding domain protein
U068_RS13390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U068_RS13395	COG5544	Lipoprotein
U068_RS13400	COG0477	Major facilitator Superfamily
U068_RS13435	COG0542	response to heat
U068_RS13440	COG1496	oxidoreductase activity
U068_RS13445	COG0564	pseudouridine synthase activity
U068_RS13450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U068_RS13460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U068_RS13465	COG0077	Prephenate dehydratase
U068_RS13465	COG1605	Chorismate mutase
U068_RS13470	COG1605	Chorismate mutase
U068_RS13470	COG0287	Prephenate dehydrogenase
U068_RS13475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
U068_RS13490	COG2199	diguanylate cyclase activity
U068_RS13495	COG2885	chlorophyll binding
U068_RS13520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U068_RS13525	COG4137	Cytochrome C assembly protein
U068_RS13530	COG4536	flavin adenine dinucleotide binding
U068_RS13550	COG0497	DNA recombination
U068_RS13555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U068_RS13565	COG2867	negative regulation of translational initiation
U068_RS13580	COG0582	viral genome integration into host DNA
U068_RS13590	COG3311	Transcriptional regulator
U068_RS13595	COG4983	Phage plasmid primase, P4 family domain protein
U068_RS13605	COG1204	response to ionizing radiation
U068_RS13615	COG1479	Protein of unknown function DUF262
U068_RS13630	COG3596	GTP binding
U068_RS13640	COG2378	regulation of single-species biofilm formation
U068_RS13680	COG2003	Belongs to the UPF0758 family
U068_RS13695	COG3468	outer membrane autotransporter barrel domain protein
U068_RS13720	COG0366	Alpha amylase catalytic
U068_RS13725	COG0366	Alpha amylase catalytic
U068_RS13730	COG0366	Alpha amylase catalytic
U068_RS13740	COG0579	oxidoreductase
U068_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS13750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
U068_RS13755	COG1113	amino acid transport
U068_RS13760	COG1802	Transcriptional regulator
U068_RS13765	COG1652	LysM domain
U068_RS13770	COG0401	homolog of Blt101
U068_RS13775	COG0640	Transcriptional regulator
U068_RS13780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U068_RS13785	COG2916	Histone family protein nucleoid-structuring protein H-NS
U068_RS13800	COG4575	ribosome binding
U068_RS13805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U068_RS13815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U068_RS13820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U068_RS13825	COG4175	Glycine betaine
U068_RS13830	COG4176	ABC-type proline glycine betaine transport system permease component
U068_RS13835	COG2113	Glycine betaine
U068_RS13845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
U068_RS13855	COG1846	Transcriptional regulator
U068_RS13860	COG1566	PFAM secretion protein HlyD family protein
U068_RS13865	COG2814	Major facilitator Superfamily
U068_RS13880	COG1238	metal cluster binding
U068_RS13885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U068_RS13915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
U068_RS13940	COG1546	Belongs to the CinA family
U068_RS13945	COG2951	lytic endotransglycosylase activity
U068_RS13950	COG3730	PTS system glucitol sorbitol-specific
U068_RS13955	COG3732	PTS system glucitol sorbitol-specific
U068_RS13960	COG3731	PTS system glucitol sorbitol-specific IIA component
U068_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS13970	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS13975	COG1349	DNA-binding transcription factor activity
U068_RS13980	COG0517	IMP dehydrogenase activity
U068_RS13980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U068_RS14000	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
U068_RS14005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS14010	COG1609	Transcriptional regulator
U068_RS14015	COG1263	PTS System
U068_RS14015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS14020	COG2723	6-phospho-beta-galactosidase activity
U068_RS14025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U068_RS14035	COG3260	NADH ubiquinone oxidoreductase 20
U068_RS14040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
U068_RS14045	COG3261	NADH dehydrogenase
U068_RS14045	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
U068_RS14050	COG0650	Formate hydrogenlyase subunit 4
U068_RS14055	COG0651	ATP synthesis coupled electron transport
U068_RS14060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS14075	COG0375	protein maturation
U068_RS14080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
U068_RS14085	COG0298	carbon dioxide binding
U068_RS14090	COG0409	Hydrogenase expression formation protein
U068_RS14095	COG0309	Hydrogenase expression formation protein (HypE)
U068_RS14100	COG3604	Transcriptional regulator
U068_RS14115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U068_RS14120	COG1349	DNA-binding transcription factor activity
U068_RS14125	COG2084	Dehydrogenase
U068_RS14130	COG3395	kinase activity
U068_RS14135	COG0235	Class ii aldolase
U068_RS14140	COG3622	Belongs to the hyi family
U068_RS14145	COG2610	gluconate transmembrane transporter activity
U068_RS14150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U068_RS14155	COG4942	peptidase
U068_RS14155	COG1388	LysM domain
U068_RS14210	COG2234	aminopeptidase activity
U068_RS14215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U068_RS14220	COG1518	maintenance of DNA repeat elements
U068_RS14235	COG1857	crispr-associated protein
U068_RS14250	COG1203	CRISPR-associated helicase, Cas3
U068_RS14265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U068_RS14270	COG0720	synthase
U068_RS14275	COG0644	oxidoreductase
U068_RS14280	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
U068_RS14285	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
U068_RS14290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
U068_RS14295	COG2086	electron transfer activity
U068_RS14300	COG0477	Major facilitator Superfamily
U068_RS14305	COG0277	FAD linked oxidase domain protein
U068_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS14315	COG2223	nitrite transmembrane transporter activity
U068_RS14320	COG1070	Carbohydrate kinase
U068_RS14325	COG0602	queuosine metabolic process
U068_RS14335	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
U068_RS14350	COG3956	TIGRFAM MazG family protein
U068_RS14355	COG2337	Toxic component of a toxin-antitoxin (TA) module
U068_RS14360	COG2336	PFAM SpoVT AbrB
U068_RS14365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U068_RS14370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U068_RS14375	COG3850	Histidine kinase
U068_RS14375	COG3437	response regulator, receiver
U068_RS14375	COG4999	Histidine kinase
U068_RS14375	COG2205	protein histidine kinase activity
U068_RS14380	COG4948	Mandelate Racemase Muconate Lactonizing
U068_RS14385	COG4948	Mandelate Racemase Muconate Lactonizing
U068_RS14390	COG2271	Major facilitator Superfamily
U068_RS14395	COG0716	FMN binding
U068_RS14400	COG0564	pseudouridine synthase activity
U068_RS14405	COG3098	single-species biofilm formation
U068_RS14425	COG1611	Belongs to the LOG family
U068_RS14430	COG0814	amino acid
U068_RS14435	COG1760	l-serine dehydratase
U068_RS14445	COG1454	alcohol dehydrogenase
U068_RS14450	COG0235	Class ii aldolase
U068_RS14455	COG0738	Major facilitator superfamily
U068_RS14465	COG1070	Carbohydrate kinase
U068_RS14475	COG1349	DNA-binding transcription factor activity
U068_RS14485	COG2363	Small membrane protein
U068_RS14490	COG0583	DNA-binding transcription factor activity
U068_RS14500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U068_RS14505	COG2166	iron-sulfur cluster assembly
U068_RS14510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
U068_RS14515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
U068_RS14535	COG0860	N-Acetylmuramoyl-L-alanine amidase
U068_RS14540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
U068_RS14540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
U068_RS14545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U068_RS14550	COG1074	ATP-dependent DNA helicase activity
U068_RS14555	COG1025	Belongs to the peptidase M16 family
U068_RS14560	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
U068_RS14565	COG4967	type IV pilus modification protein PilV
U068_RS14575	COG4795	General secretion pathway protein
U068_RS14580	COG2165	general secretion pathway protein
U068_RS14595	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
U068_RS14620	COG0861	Integral membrane protein TerC family
U068_RS14630	COG0667	Aldo Keto reductase
U068_RS14645	COG1609	Transcriptional regulator
U068_RS14655	COG0583	DNA-binding transcription factor activity
U068_RS14660	COG1794	racemase activity, acting on amino acids and derivatives
U068_RS14665	COG2814	Major facilitator Superfamily
U068_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS14680	COG0183	Belongs to the thiolase family
U068_RS14685	COG0814	amino acid
U068_RS14690	COG2771	luxR family
U068_RS14695	COG3710	Transcriptional regulator
U068_RS14715	COG0457	Tetratricopeptide repeat
U068_RS14735	COG2197	response regulator
U068_RS14740	COG2197	response regulator
U068_RS14770	COG3387	PFAM Glycoside hydrolase 15-related
U068_RS14775	COG3387	PFAM Glycoside hydrolase 15-related
U068_RS14785	COG4942	peptidase
U068_RS14790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U068_RS14795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U068_RS14800	COG2080	2 iron, 2 sulfur cluster binding
U068_RS14805	COG3829	transcription factor binding
U068_RS14810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U068_RS14815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U068_RS14820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U068_RS14830	COG0549	Belongs to the carbamate kinase family
U068_RS14835	COG3608	succinylglutamate desuccinylase aspartoacylase
U068_RS14835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U068_RS14840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U068_RS14845	COG2068	MobA-Related Protein
U068_RS14850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS14850	COG0493	'glutamate synthase
U068_RS14855	COG0402	S-adenosylhomocysteine deaminase activity
U068_RS14860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U068_RS14865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U068_RS14865	COG2080	2 iron, 2 sulfur cluster binding
U068_RS14870	COG2233	PERMEase
U068_RS14875	COG0402	S-adenosylhomocysteine deaminase activity
U068_RS14880	COG2252	PERMEase
U068_RS14885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS14890	COG0493	'glutamate synthase
U068_RS14890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS14900	COG2233	PERMEase
U068_RS14915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U068_RS14925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
U068_RS14930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U068_RS14935	COG4974	Belongs to the 'phage' integrase family
U068_RS14940	COG0716	FMN binding
U068_RS14950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
U068_RS14960	COG1272	protein, Hemolysin III
U068_RS14970	COG2723	6-phospho-beta-galactosidase activity
U068_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS14995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U068_RS15000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U068_RS15005	COG0006	proline dipeptidase activity
U068_RS15025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
U068_RS15030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U068_RS15050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
U068_RS15050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
U068_RS15055	COG1703	isobutyryl-CoA mutase activity
U068_RS15060	COG1024	Enoyl-CoA hydratase
U068_RS15065	COG0427	acetyl-CoA hydrolase
U068_RS15070	COG0583	DNA-binding transcription factor activity
U068_RS15075	COG2968	Membrane
U068_RS15080	COG1279	arginine transmembrane transporter activity
U068_RS15085	COG0668	transmembrane transport
U068_RS15090	COG0191	fructose-bisphosphate aldolase activity
U068_RS15105	COG1072	(Pantothenic acid kinase))
U068_RS15110	COG3722	fumarate hydratase activity
U068_RS15115	COG1494	fructose-1,6-bisphosphatase
U068_RS15120	COG1063	alcohol dehydrogenase
U068_RS15125	COG2213	PTS system mannitol-specific
U068_RS15130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS15135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U068_RS15140	COG0501	Belongs to the peptidase M48B family
U068_RS15150	COG1166	arginine decarboxylase activity
U068_RS15175	COG2814	Major facilitator Superfamily
U068_RS15185	COG2356	endonuclease I
U068_RS15190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U068_RS15195	COG0189	ligase activity
U068_RS15210	COG2805	Type II/IV secretion system protein
U068_RS15215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U068_RS15220	COG0762	integral membrane protein
U068_RS15230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
U068_RS15235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U068_RS15245	COG0252	asparaginase activity
U068_RS15260	COG3171	Protein conserved in bacteria
U068_RS15270	COG1194	a g-specific adenine glycosylase
U068_RS15285	COG2211	Major facilitator Superfamily
U068_RS15290	COG1982	Orn Lys Arg decarboxylase major
U068_RS15295	COG1811	Na channel or pump
U068_RS15305	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
U068_RS15315	COG3031	protein transport across the cell outer membrane
U068_RS15325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
U068_RS15330	COG3064	Membrane
U068_RS15340	COG1620	l-lactate permease
U068_RS15345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
U068_RS15350	COG3193	protein, possibly involved in utilization of glycolate and propanediol
U068_RS15355	COG0247	lactate metabolic process
U068_RS15360	COG0277	FAD linked oxidase domain protein
U068_RS15365	COG0277	FAD linked oxidase domain protein
U068_RS15370	COG2186	Transcriptional regulator
U068_RS15375	COG0456	acetyltransferase
U068_RS15385	COG2244	polysaccharide biosynthetic process
U068_RS15390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U068_RS15395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U068_RS15400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U068_RS15405	COG0306	phosphate transporter
U068_RS15410	COG0754	glutathionylspermidine amidase activity
U068_RS15415	COG0625	glutathione transferase activity
U068_RS15420	COG0298	carbon dioxide binding
U068_RS15430	COG1773	rubredoxin
U068_RS15435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U068_RS15440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
U068_RS15445	COG5557	Pfam Polysulphide reductase, NrfD
U068_RS15450	COG0437	4 iron, 4 sulfur cluster binding
U068_RS15455	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
U068_RS15475	COG0667	Aldo Keto reductase
U068_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS15490	COG0848	biopolymer transport protein
U068_RS15495	COG0811	peptide transport
U068_RS15505	COG0626	cystathionine gamma-synthase activity
U068_RS15510	COG0586	Pfam SNARE associated Golgi protein
U068_RS15515	COG2207	Transcriptional regulator
U068_RS15525	COG1979	alcohol dehydrogenase
U068_RS15530	COG0656	L-ascorbic acid biosynthetic process
U068_RS15540	COG4238	major outer membrane lipoprotein
U068_RS15545	COG1032	radical SAM domain protein
U068_RS15550	COG2132	Multicopper oxidase
U068_RS15555	COG0204	Acyl-transferase
U068_RS15560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U068_RS15565	COG4166	transmembrane transport
U068_RS15570	COG2944	sequence-specific DNA binding
U068_RS15580	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
U068_RS15585	COG3111	PFAM Bacterial OB fold (BOF) protein
U068_RS15590	COG0745	RESPONSE REGULATOR receiver
U068_RS15595	COG0642	Histidine kinase
U068_RS15605	COG2249	NAD(P)H dehydrogenase (quinone) activity
U068_RS15610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
U068_RS15615	COG0187	DNA topoisomerase II activity
U068_RS15620	COG3150	esterase
U068_RS15625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
U068_RS15630	COG3151	Protein conserved in bacteria
U068_RS15635	COG0494	nUDIX hydrolase
U068_RS15640	COG1538	Outer membrane efflux protein
U068_RS15655	COG0754	glutathionylspermidine amidase activity
U068_RS15660	COG3384	dioxygenase
U068_RS15680	COG2960	long-chain fatty acid transporting porin activity
U068_RS15685	COG3539	Fimbrial protein
U068_RS15700	COG3188	usher protein
U068_RS15705	COG3121	Chaperone
U068_RS15710	COG3539	Fimbrial protein
U068_RS15720	COG1585	Membrane protein implicated in regulation of membrane protease activity
U068_RS15725	COG2268	Band 7 protein
U068_RS15750	COG3025	triphosphatase activity
U068_RS15760	COG4991	sh3 domain protein
U068_RS15775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U068_RS15785	COG0583	DNA-binding transcription factor activity
U068_RS15790	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
U068_RS15800	COG0471	metal ion transport
U068_RS15810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
U068_RS15815	COG0358	DNA primase activity
U068_RS15820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U068_RS15835	COG2375	cellular response to nickel ion
U068_RS15840	COG1695	Transcriptional regulator
U068_RS15845	COG0840	transmembrane signaling receptor activity
U068_RS15855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U068_RS15860	COG1609	Transcriptional regulator
U068_RS15865	COG3250	beta-galactosidase activity
U068_RS15870	COG2731	YhcH YjgK YiaL family protein
U068_RS15875	COG0531	amino acid
U068_RS15885	COG3408	Glycogen debranching enzyme
U068_RS15885	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
U068_RS15890	COG0446	pyridine nucleotide-disulphide oxidoreductase
U068_RS15890	COG1902	pentaerythritol trinitrate reductase activity
U068_RS15895	COG5499	transcription regulator containing HTH domain
U068_RS15900	COG4680	protein conserved in bacteria
U068_RS15915	COG1451	nucleotide metabolic process
U068_RS15920	COG2949	membrane
U068_RS15925	COG0673	inositol 2-dehydrogenase activity
U068_RS15930	COG0861	Integral membrane protein TerC family
U068_RS15935	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
U068_RS15945	COG2721	sulfolactate sulfo-lyase activity
U068_RS15955	COG2271	Major facilitator Superfamily
U068_RS15960	COG2186	Transcriptional regulator
U068_RS15965	COG0586	Pfam SNARE associated Golgi protein
U068_RS15975	COG1422	Protein of unknown function (DUF1090)
U068_RS15980	COG4575	ribosome binding
U068_RS15985	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
U068_RS15995	COG2259	Doxx family
U068_RS16000	COG0435	Glutathione S-transferase
U068_RS16005	COG3152	Membrane
U068_RS16010	COG3152	Membrane
U068_RS16015	COG0583	DNA-binding transcription factor activity
U068_RS16020	COG1741	Belongs to the pirin family
U068_RS16035	COG0814	amino acid
U068_RS16040	COG1760	l-serine dehydratase
U068_RS16045	COG0251	oxidation-reduction process
U068_RS16050	COG1882	Formate acetyltransferase
U068_RS16055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U068_RS16065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U068_RS16070	COG0583	DNA-binding transcription factor activity
U068_RS16095	COG1929	Belongs to the glycerate kinase type-1 family
U068_RS16100	COG2084	Dehydrogenase
U068_RS16110	COG2271	Major facilitator Superfamily
U068_RS16115	COG2721	sulfolactate sulfo-lyase activity
U068_RS16120	COG2002	toxin-antitoxin pair type II binding
U068_RS16130	COG1349	DNA-binding transcription factor activity
U068_RS16140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS16150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U068_RS16155	COG2222	sugar isomerase
U068_RS16165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS16170	COG3715	PTS system
U068_RS16175	COG3716	PTS system mannose fructose sorbose family IID component
U068_RS16180	COG0363	glucosamine-6-phosphate deaminase activity
U068_RS16185	COG3539	Fimbrial protein
U068_RS16190	COG3121	Chaperone
U068_RS16195	COG3188	usher protein
U068_RS16200	COG3539	Fimbrial protein
U068_RS16205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U068_RS16210	COG3107	peptidoglycan biosynthetic process
U068_RS16225	COG2823	Periplasmic or secreted lipoprotein
U068_RS16230	COG0701	Predicted permease
U068_RS16235	COG0702	epimerase
U068_RS16240	COG0693	protein deglycase activity
U068_RS16255	COG3153	acetyltransferase
U068_RS16260	COG3154	lipid carrier protein
U068_RS16265	COG0826	peptidase U32
U068_RS16270	COG0826	peptidase U32
U068_RS16275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U068_RS16280	COG0814	amino acid
U068_RS16290	COG0513	Belongs to the DEAD box helicase family
U068_RS16325	COG0195	Participates in both transcription termination and antitermination
U068_RS16345	COG2194	sulfuric ester hydrolase activity
U068_RS16355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U068_RS16365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U068_RS16370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U068_RS16380	COG1534	Rna-binding protein
U068_RS16385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U068_RS16390	COG2027	D-alanyl-D-alanine carboxypeptidase
U068_RS16400	COG0697	spore germination
U068_RS16415	COG0142	geranyltranstransferase activity
U068_RS16420	COG3423	Transcriptional regulator
U068_RS16430	COG5007	Belongs to the BolA IbaG family
U068_RS16435	COG3113	response to antibiotic
U068_RS16440	COG2854	intermembrane phospholipid transfer
U068_RS16445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
U068_RS16450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
U068_RS16455	COG1127	ABC transporter
U068_RS16460	COG0530	calcium, potassium:sodium antiporter activity
U068_RS16465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U068_RS16465	COG0517	IMP dehydrogenase activity
U068_RS16470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
U068_RS16475	COG3117	lipopolysaccharide transmembrane transporter activity
U068_RS16480	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
U068_RS16485	COG1137	ATPase activity
U068_RS16490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U068_RS16495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U068_RS16510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS16515	COG0515	serine threonine protein kinase
U068_RS16525	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
U068_RS16535	COG0784	Response regulator, receiver
U068_RS16535	COG5002	protein histidine kinase activity
U068_RS16535	COG2198	Histidine kinase
U068_RS16540	COG1242	4 iron, 4 sulfur cluster binding
U068_RS16545	COG0069	glutamate synthase activity
U068_RS16545	COG0070	glutamate synthase
U068_RS16545	COG0067	glutamate synthase
U068_RS16550	COG0493	'glutamate synthase
U068_RS16555	COG3539	Fimbrial protein
U068_RS16560	COG3121	Chaperone
U068_RS16565	COG3188	usher protein
U068_RS16585	COG3539	Fimbrial protein
U068_RS16590	COG4804	nuclease activity
U068_RS16595	COG2731	YhcH YjgK YiaL family protein
U068_RS16625	COG3069	C4-dicarboxylate transmembrane transporter activity
U068_RS16630	COG2969	positive regulation of protein catabolic process
U068_RS16635	COG0625	glutathione transferase activity
U068_RS16650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
U068_RS16655	COG3105	Protein conserved in bacteria
U068_RS16660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U068_RS16665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U068_RS16685	COG2732	(Barnase) inhibitor
U068_RS16705	COG0583	DNA-binding transcription factor activity
U068_RS16710	COG0312	modulator of DNA gyrase
U068_RS16715	COG3164	Protein of unknown function
U068_RS16720	COG1530	ribonuclease E activity
U068_RS16725	COG0424	maF-like protein
U068_RS16730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
U068_RS16735	COG1792	Involved in formation and maintenance of cell shape
U068_RS16740	COG1077	Cell shape determining protein MreB Mrl
U068_RS16750	COG2200	EAL domain
U068_RS16750	COG2199	diguanylate cyclase activity
U068_RS16755	COG0604	alcohol dehydrogenase
U068_RS16775	COG0511	ligase activity, forming carbon-carbon bonds
U068_RS16780	COG0439	Biotin carboxylase
U068_RS16785	COG3924	membrane
U068_RS16790	COG4145	pantothenate transmembrane transporter activity
U068_RS16800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U068_RS16810	COG2189	Belongs to the N(4) N(6)-methyltransferase family
U068_RS16820	COG1309	transcriptional regulator
U068_RS16825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS16830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U068_RS16845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U068_RS16850	COG4597	amino acid ABC transporter
U068_RS16855	COG0765	amino acid transport
U068_RS16860	COG1126	abc transporter atp-binding protein
U068_RS16890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U068_RS16895	COG2801	Transposase and inactivated derivatives
U068_RS16915	COG0551	DNA topoisomerase type I activity
U068_RS16925	COG0758	DNA mediated transformation
U068_RS16945	COG0569	domain protein
U068_RS16955	COG3036	rescue of stalled ribosome
U068_RS16960	COG0789	Transcriptional regulator
U068_RS17000	COG0201	protein transport
U068_RS17090	COG0089	rRNA binding
U068_RS17115	COG3267	Type II secretory pathway component ExeA
U068_RS17115	COG3409	Peptidoglycan-binding domain 1 protein
U068_RS17120	COG3031	protein transport across the cell outer membrane
U068_RS17125	COG1450	Type ii and iii secretion system protein
U068_RS17130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U068_RS17135	COG1459	type II secretion system
U068_RS17140	COG2165	general secretion pathway protein
U068_RS17145	COG2165	general secretion pathway protein
U068_RS17150	COG2165	general secretion pathway protein
U068_RS17155	COG4795	General secretion pathway protein
U068_RS17160	COG3156	type II secretion system protein K
U068_RS17165	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
U068_RS17170	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
U068_RS17175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
U068_RS17180	COG2193	ferroxidase activity
U068_RS17185	COG2906	2 iron, 2 sulfur cluster binding
U068_RS17190	COG3979	chitinase
U068_RS17230	COG2964	Protein conserved in bacteria
U068_RS17235	COG0545	Peptidyl-prolyl cis-trans isomerase
U068_RS17245	COG1047	Peptidyl-prolyl cis-trans
U068_RS17250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
U068_RS17265	COG0488	(ABC) transporter
U068_RS17270	COG0429	hydrolase of the alpha beta-hydrolase fold
U068_RS17280	COG3954	Phosphoribulokinase
U068_RS17285	COG1765	OsmC-like protein
U068_RS17295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U068_RS17300	COG1289	transmembrane transporter activity
U068_RS17305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U068_RS17310	COG0512	Glutamine amidotransferase of anthranilate synthase
U068_RS17315	COG2184	nucleotidyltransferase activity
U068_RS17325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U068_RS17335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U068_RS17340	COG2146	nitrite reductase [NAD(P)H] activity
U068_RS17345	COG2116	formate transmembrane transporter activity
U068_RS17360	COG0531	amino acid
U068_RS17365	COG2222	sugar isomerase
U068_RS17370	COG1082	Xylose isomerase domain protein TIM barrel
U068_RS17375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS17380	COG2188	Transcriptional regulator
U068_RS17385	COG0626	cystathionine gamma-synthase activity
U068_RS17400	COG1735	metal-dependent hydrolase with the TIM-barrel fold
U068_RS17405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
U068_RS17410	COG3457	Alanine racemase
U068_RS17420	COG2188	Transcriptional regulator
U068_RS17425	COG0180	Tryptophanyl-tRNA synthetase
U068_RS17430	COG0546	phosphoglycolate phosphatase activity
U068_RS17435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U068_RS17440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U068_RS17445	COG3266	domain, Protein
U068_RS17460	COG4796	Type ii and iii secretion system protein
U068_RS17475	COG3166	PFAM Fimbrial assembly family protein
U068_RS17480	COG4972	Pilus assembly protein
U068_RS17485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
U068_RS17490	COG0494	nUDIX hydrolase
U068_RS17500	COG1011	Hydrolase
U068_RS17505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
U068_RS17515	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
U068_RS17540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U068_RS17545	COG2183	response to ionizing radiation
U068_RS17550	COG1918	ferrous iron import across plasma membrane
U068_RS17555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
U068_RS17565	COG5464	transposase or invertase
U068_RS17575	COG1040	competence protein
U068_RS17585	COG2610	gluconate transmembrane transporter activity
U068_RS17590	COG1640	4-alpha-glucanotransferase
U068_RS17595	COG0058	SHG alpha-glucan phosphorylase activity
U068_RS17610	COG1690	Belongs to the RtcB family
U068_RS17615	COG4650	regulator
U068_RS17620	COG1349	DNA-binding transcription factor activity
U068_RS17635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
U068_RS17640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
U068_RS17645	COG0058	SHG alpha-glucan phosphorylase activity
U068_RS17670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U068_RS17675	COG2095	MarC family integral membrane protein
U068_RS17680	COG2610	gluconate transmembrane transporter activity
U068_RS17685	COG3265	gluconokinase activity
U068_RS17690	COG1609	Transcriptional regulator
U068_RS17695	COG1741	Belongs to the pirin family
U068_RS17700	COG0673	inositol 2-dehydrogenase activity
U068_RS17705	COG1247	-acetyltransferase
U068_RS17710	COG3157	Type VI secretion system effector, Hcp
U068_RS17730	COG0405	Gamma-glutamyltransferase
U068_RS17740	COG0584	glycerophosphoryl diester phosphodiesterase
U068_RS17745	COG3842	ATPase activity
U068_RS17750	COG0395	ABC-type sugar transport system, permease component
U068_RS17755	COG1175	transmembrane transport
U068_RS17760	COG1653	transport
U068_RS17770	COG0410	ABC transporter
U068_RS17775	COG0411	ABC transporter
U068_RS17780	COG4177	L-phenylalanine transmembrane transporter activity
U068_RS17785	COG0559	Belongs to the binding-protein-dependent transport system permease family
U068_RS17790	COG0683	leucine binding
U068_RS17795	COG0456	acetyltransferase
U068_RS17805	COG0683	leucine binding
U068_RS17810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U068_RS17815	COG2177	Part of the ABC transporter FtsEX involved in
U068_RS17820	COG2884	Cell division ATP-binding protein ftsE
U068_RS17825	COG0552	protein localization to endoplasmic reticulum
U068_RS17830	COG0742	ribosomal rna small subunit methyltransferase
U068_RS17835	COG3776	membrane
U068_RS17845	COG3714	YhhN family
U068_RS17850	COG2217	Heavy metal translocating P-type atpase
U068_RS17860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
U068_RS17870	COG0477	Major facilitator Superfamily
U068_RS17875	COG0628	permease
U068_RS17880	COG2091	lysine biosynthetic process via aminoadipic acid
U068_RS17885	COG0747	negative chemotaxis
U068_RS17890	COG0601	transmembrane transport
U068_RS17895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U068_RS17900	COG0444	Belongs to the ABC transporter superfamily
U068_RS17905	COG1124	(ABC) transporter
U068_RS17915	COG3209	COG3209 Rhs family protein
U068_RS17930	COG5433	transposase activity
U068_RS17935	COG0842	Transport permease protein
U068_RS17940	COG1129	ABC transporter
U068_RS17940	COG0842	Transport permease protein
U068_RS17945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS17975	COG2081	HI0933 family
U068_RS17980	COG0306	phosphate transporter
U068_RS17990	COG0589	response to stress
U068_RS17995	COG3104	oligopeptide transport
U068_RS18005	COG0339	signal peptide processing
U068_RS18010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
U068_RS18015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U068_RS18030	COG0640	Transcriptional regulator
U068_RS18035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U068_RS18040	COG1393	Belongs to the ArsC family
U068_RS18060	COG3065	identical protein binding
U068_RS18065	COG2197	response regulator
U068_RS18070	COG1285	pathogenesis
U068_RS18085	COG3247	response to pH
U068_RS18090	COG2771	luxR family
U068_RS18100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U068_RS18105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U068_RS18110	COG2207	Transcriptional regulator
U068_RS18115	COG2207	Transcriptional regulator
U068_RS18120	COG0076	glutamate decarboxylase activity
U068_RS18125	COG1858	cytochrome C peroxidase
U068_RS18135	COG2197	response regulator
U068_RS18140	COG0583	DNA-binding transcription factor activity
U068_RS18145	COG1295	ribonuclease BN
U068_RS18150	COG0477	Major facilitator Superfamily
U068_RS18155	COG2982	Protein involved in outer membrane biogenesis
U068_RS18160	COG2200	EAL domain
U068_RS18170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS18175	COG0612	Peptidase, M16
U068_RS18185	COG2200	EAL domain
U068_RS18185	COG2199	diguanylate cyclase activity
U068_RS18190	COG3118	belongs to the thioredoxin family
U068_RS18190	COG0457	Tetratricopeptide repeat
U068_RS18195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
U068_RS18200	COG1215	transferase activity, transferring glycosyl groups
U068_RS18205	COG1215	transferase activity, transferring glycosyl groups
U068_RS18230	COG2194	sulfuric ester hydrolase activity
U068_RS18245	COG0814	amino acid
U068_RS18250	COG4608	Belongs to the ABC transporter superfamily
U068_RS18255	COG0444	Belongs to the ABC transporter superfamily
U068_RS18260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U068_RS18265	COG0601	transmembrane transport
U068_RS18275	COG0747	negative chemotaxis
U068_RS18295	COG2194	sulfuric ester hydrolase activity
U068_RS18300	COG2223	nitrite transmembrane transporter activity
U068_RS18305	COG5571	outer membrane autotransporter
U068_RS18310	COG2818	Glycosylase
U068_RS18315	COG0456	acetyltransferase
U068_RS18320	COG0243	molybdopterin cofactor binding
U068_RS18325	COG2885	chlorophyll binding
U068_RS18340	COG2944	sequence-specific DNA binding
U068_RS18345	COG1278	Cold shock
U068_RS18355	COG2963	transposase activity
U068_RS18360	COG2801	Transposase and inactivated derivatives
U068_RS18380	COG3274	enterobacterial common antigen metabolic process
U068_RS18385	COG4682	membrane
U068_RS18390	COG4682	membrane
U068_RS18395	COG1070	Carbohydrate kinase
U068_RS18405	COG4213	ABC transporter substrate-binding protein
U068_RS18410	COG1129	ABC transporter
U068_RS18415	COG4214	carbohydrate transport
U068_RS18420	COG2207	Transcriptional regulator
U068_RS18420	COG1609	Transcriptional regulator
U068_RS18425	COG2992	FlgJ-related protein
U068_RS18430	COG0366	Alpha amylase catalytic
U068_RS18435	COG3977	Valine--pyruvate aminotransferase
U068_RS18445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
U068_RS18450	COG1414	Transcriptional regulator
U068_RS18460	COG2731	YhcH YjgK YiaL family protein
U068_RS18465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
U068_RS18470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
U068_RS18475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
U068_RS18480	COG1070	Carbohydrate kinase
U068_RS18485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
U068_RS18490	COG3623	hexulose-6-phosphate isomerase
U068_RS18495	COG0235	Class ii aldolase
U068_RS18500	COG3713	MltA-interacting MipA family protein
U068_RS18505	COG0583	DNA-binding transcription factor activity
U068_RS18510	COG1566	PFAM secretion protein HlyD family protein
U068_RS18525	COG1012	belongs to the aldehyde dehydrogenase family
U068_RS18530	COG1454	alcohol dehydrogenase
U068_RS18535	COG3276	selenocysteine insertion sequence binding
U068_RS18545	COG0625	glutathione transferase activity
U068_RS18550	COG3209	COG3209 Rhs family protein
U068_RS18565	COG3188	usher protein
U068_RS18570	COG3209	COG3209 Rhs family protein
U068_RS18575	COG1413	lyase activity
U068_RS18580	COG3209	COG3209 Rhs family protein
U068_RS18585	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U068_RS18595	COG1566	PFAM secretion protein HlyD family protein
U068_RS18605	COG2213	PTS system mannitol-specific
U068_RS18605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS18615	COG3722	fumarate hydratase activity
U068_RS18630	COG1620	l-lactate permease
U068_RS18635	COG2186	Transcriptional regulator
U068_RS18645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U068_RS18650	COG1045	serine acetyltransferase
U068_RS18665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U068_RS18670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U068_RS18675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
U068_RS18680	COG4942	peptidase
U068_RS18685	COG2861	carbohydrate metabolic process
U068_RS18690	COG1216	Glycosyl transferase, family 2
U068_RS18700	COG0156	8-amino-7-oxononanoate synthase activity
U068_RS18715	COG0859	PFAM glycosyl transferase family 9
U068_RS18720	COG0859	PFAM glycosyl transferase family 9
U068_RS18725	COG3307	-O-antigen
U068_RS18730	COG0859	PFAM glycosyl transferase family 9
U068_RS18740	COG3642	lipopolysaccharide core region biosynthetic process
U068_RS18745	COG1442	glycosyl transferase family 8
U068_RS18750	COG1442	glycosyl transferase family 8
U068_RS18755	COG0438	transferase activity, transferring glycosyl groups
U068_RS18760	COG0438	transferase activity, transferring glycosyl groups
U068_RS18760	COG4641	Protein conserved in bacteria
U068_RS18765	COG0515	serine threonine protein kinase
U068_RS18770	COG0438	transferase activity, transferring glycosyl groups
U068_RS18775	COG0859	PFAM glycosyl transferase family 9
U068_RS18780	COG1519	Transferase
U068_RS18810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U068_RS18815	COG0756	dUTP diphosphatase activity
U068_RS18835	COG1561	YicC-like family, N-terminal region
U068_RS18840	COG3645	SOS response
U068_RS18845	COG2860	membrane
U068_RS18855	COG0194	GDP metabolic process
U068_RS18865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U068_RS18870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U068_RS18875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U068_RS18880	COG0786	glutamate:sodium symporter activity
U068_RS18885	COG2233	PERMEase
U068_RS18890	COG2982	Protein involved in outer membrane biogenesis
U068_RS18895	COG1501	Belongs to the glycosyl hydrolase 31 family
U068_RS18900	COG2211	Major facilitator Superfamily
U068_RS18915	COG2814	Major facilitator Superfamily
U068_RS18920	COG0697	spore germination
U068_RS18925	COG1464	Belongs to the NlpA lipoprotein family
U068_RS18950	COG2252	PERMEase
U068_RS18960	COG2271	Major facilitator Superfamily
U068_RS18965	COG2271	Major facilitator Superfamily
U068_RS18970	COG3851	Histidine kinase
U068_RS18975	COG2197	response regulator
U068_RS18980	COG0440	acetolactate synthase activity
U068_RS18985	COG0028	Belongs to the TPP enzyme family
U068_RS19010	COG2814	Major facilitator Superfamily
U068_RS19015	COG0641	radical SAM
U068_RS19025	COG2149	membrane
U068_RS19035	COG3119	arylsulfatase activity
U068_RS19040	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U068_RS19045	COG2207	Transcriptional regulator
U068_RS19055	COG1263	PTS System
U068_RS19055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS19060	COG1263	PTS System
U068_RS19065	COG2188	Transcriptional regulator
U068_RS19085	COG5645	(Lipo)protein
U068_RS19090	COG0823	Involved in the tonB-independent uptake of proteins
U068_RS19095	COG0644	oxidoreductase
U068_RS19100	COG2271	Major facilitator Superfamily
U068_RS19110	COG0800	Aldolase
U068_RS19115	COG3734	2-keto-3-deoxy-galactonokinase
U068_RS19120	COG2186	Transcriptional regulator
U068_RS19130	COG0561	phosphatase activity
U068_RS19135	COG3753	Protein conserved in bacteria
U068_RS19145	COG0187	DNA topoisomerase II activity
U068_RS19155	COG0592	DNA-directed DNA polymerase activity
U068_RS19205	COG0814	amino acid
U068_RS19220	COG2091	lysine biosynthetic process via aminoadipic acid
U068_RS19225	COG0431	NADPH-dependent FMN reductase
U068_RS19230	COG2252	PERMEase
U068_RS19235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U068_RS19245	COG3196	Protein conserved in bacteria
U068_RS19250	COG0363	glucosamine-6-phosphate deaminase activity
U068_RS19255	COG2382	esterase
U068_RS19265	COG2723	6-phospho-beta-galactosidase activity
U068_RS19270	COG2190	(PTS) system
U068_RS19270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS19270	COG1263	PTS System
U068_RS19275	COG3711	transcriptional antiterminator
U068_RS19280	COG0704	Plays a role in the regulation of phosphate uptake
U068_RS19285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U068_RS19290	COG0581	inorganic phosphate transmembrane transporter activity
U068_RS19295	COG0573	inorganic phosphate transmembrane transporter activity
U068_RS19300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
U068_RS19305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U068_RS19355	COG3312	ion transport
U068_RS19370	COG0716	FMN binding
U068_RS19375	COG1522	sequence-specific DNA binding
U068_RS19405	COG1129	ABC transporter
U068_RS19410	COG1172	Belongs to the binding-protein-dependent transport system permease family
U068_RS19415	COG1879	ABC-type sugar transport system periplasmic component
U068_RS19420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS19425	COG1609	Transcriptional regulator
U068_RS19430	COG0477	Major facilitator Superfamily
U068_RS19435	COG2186	Transcriptional regulator
U068_RS19480	COG0606	chelatase, subunit chli
U068_RS19495	COG3978	acetolactate synthase activity
U068_RS19500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U068_RS19510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U068_RS19515	COG0583	DNA-binding transcription factor activity
U068_RS19525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U068_RS19535	COG0210	DNA helicase
U068_RS19550	COG3118	belongs to the thioredoxin family
U068_RS19560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
U068_RS19570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U068_RS19575	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
U068_RS19580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
U068_RS19585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
U068_RS19590	COG1088	dTDP-glucose 4,6-dehydratase activity
U068_RS19595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
U068_RS19600	COG0456	acetyltransferase
U068_RS19605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U068_RS19610	COG2244	polysaccharide biosynthetic process
U068_RS19630	COG1113	amino acid transport
U068_RS19655	COG0641	radical SAM
U068_RS19660	COG3119	arylsulfatase activity
U068_RS19665	COG3071	HemY protein
U068_RS19670	COG2959	enzyme of heme biosynthesis
U068_RS19675	COG1587	Uroporphyrinogen-III synthase
U068_RS19685	COG3072	Adenylate cyclase
U068_RS19695	COG5567	small periplasmic lipoprotein
U068_RS19705	COG3159	Protein conserved in bacteria
U068_RS19715	COG1011	Hydrolase
U068_RS19720	COG0210	DNA helicase
U068_RS19725	COG3698	Phosphodiester glycosidase
U068_RS19735	COG0598	Magnesium transport protein CorA
U068_RS19750	COG2962	Rard protein
U068_RS19755	COG2050	protein possibly involved in aromatic compounds catabolism
U068_RS19760	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
U068_RS19765	COG0514	ATP-dependent DNA helicase (RecQ)
U068_RS19770	COG1280	lysine exporter protein (LysE YggA)
U068_RS19775	COG1280	lysine exporter protein (LysE YggA)
U068_RS19780	COG2267	carboxylic ester hydrolase activity
U068_RS19785	COG0561	phosphatase activity
U068_RS19790	COG0697	spore germination
U068_RS19795	COG0583	DNA-binding transcription factor activity
U068_RS19805	COG0412	Dienelactone hydrolase
U068_RS19810	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
U068_RS19815	COG1322	Protein conserved in bacteria
U068_RS19825	COG3165	ubiquinone biosynthetic process from chorismate
U068_RS19835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U068_RS19840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U068_RS19845	COG0805	protein transport
U068_RS19850	COG0084	hydrolase, TatD family'
U068_RS19855	COG0250	Participates in transcription elongation, termination and antitermination
U068_RS19860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U068_RS19865	COG0543	2 iron, 2 sulfur cluster binding
U068_RS19870	COG0183	Belongs to the thiolase family
U068_RS19885	COG1739	Uncharacterized protein family UPF0029
U068_RS19890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U068_RS19895	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
U068_RS19920	COG1763	Mo-molybdopterin cofactor biosynthetic process
U068_RS19925	COG0746	molybdenum cofactor guanylyltransferase activity
U068_RS19930	COG3084	Protein conserved in bacteria
U068_RS19935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U068_RS19940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U068_RS19945	COG5339	Protein conserved in bacteria
U068_RS19950	COG0204	Acyl-transferase
U068_RS19960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U068_RS19960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U068_RS19975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U068_RS19985	COG2204	response regulator
U068_RS19990	COG3852	Histidine kinase
U068_RS19995	COG0174	glutamine synthetase
U068_RS20005	COG1217	gtp-binding protein TYPA
U068_RS20010	COG2188	Transcriptional regulator
U068_RS20015	COG1082	Xylose isomerase domain protein TIM barrel
U068_RS20020	COG2271	Major facilitator Superfamily
U068_RS20025	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U068_RS20030	COG2211	Major facilitator Superfamily
U068_RS20035	COG2211	Major facilitator Superfamily
U068_RS20040	COG1501	Belongs to the glycosyl hydrolase 31 family
U068_RS20045	COG2017	converts alpha-aldose to the beta-anomer
U068_RS20050	COG2942	2-epimerase
U068_RS20055	COG3684	Belongs to the aldolase LacD family
U068_RS20060	COG2084	Dehydrogenase
U068_RS20065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U068_RS20070	COG1349	DNA-binding transcription factor activity
U068_RS20075	COG1011	Hydrolase
U068_RS20090	COG0456	acetyltransferase
U068_RS20095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U068_RS20100	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
U068_RS20115	COG2864	formate dehydrogenase
U068_RS20120	COG0437	4 iron, 4 sulfur cluster binding
U068_RS20125	COG0243	molybdopterin cofactor binding
U068_RS20125	COG3383	formate dehydrogenase (NAD+) activity
U068_RS20130	COG3383	formate dehydrogenase (NAD+) activity
U068_RS20130	COG0243	molybdopterin cofactor binding
U068_RS20145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS20145	COG3711	transcriptional antiterminator
U068_RS20150	COG1363	Peptidase, m42
U068_RS20155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS20155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS20160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS20205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U068_RS20220	COG2258	MOSC domain
U068_RS20225	COG2205	protein histidine kinase activity
U068_RS20230	COG0745	RESPONSE REGULATOR receiver
U068_RS20235	COG3678	ATP-independent chaperone mediated protein folding
U068_RS20250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
U068_RS20270	COG3152	Membrane
U068_RS20275	COG3691	Protein conserved in bacteria
U068_RS20280	COG0589	response to stress
U068_RS20285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U068_RS20290	COG1494	fructose-1,6-bisphosphatase
U068_RS20300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U068_RS20315	COG1575	Belongs to the MenA family. Type 1 subfamily
U068_RS20330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U068_RS20335	COG1609	Transcriptional regulator
U068_RS20340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U068_RS20350	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
U068_RS20360	COG0626	cystathionine gamma-synthase activity
U068_RS20365	COG0527	aspartate kinase activity
U068_RS20365	COG0460	homoserine dehydrogenase
U068_RS20375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
U068_RS20385	COG0697	spore germination
U068_RS20390	COG3738	Protein conserved in bacteria
U068_RS20400	COG0371	Dehydrogenase
U068_RS20405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U068_RS20410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS20410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS20410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U068_RS20415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS20420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS20425	COG1882	Formate acetyltransferase
U068_RS20430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U068_RS20435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U068_RS20440	COG2207	Transcriptional regulator
U068_RS20445	COG2194	sulfuric ester hydrolase activity
U068_RS20465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
U068_RS20480	COG0583	DNA-binding transcription factor activity
U068_RS20505	COG4206	TonB-dependent receptor
U068_RS20540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U068_RS20545	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
U068_RS20545	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
U068_RS20585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U068_RS20590	COG0250	Participates in transcription elongation, termination and antitermination
U068_RS20630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U068_RS20640	COG2104	thiamine diphosphate biosynthetic process
U068_RS20645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U068_RS20680	COG3068	Protein conserved in bacteria
U068_RS20695	COG3678	ATP-independent chaperone mediated protein folding
U068_RS20700	COG4191	Histidine kinase
U068_RS20705	COG2204	response regulator
U068_RS20710	COG0151	Belongs to the GarS family
U068_RS20755	COG0456	acetyltransferase
U068_RS20765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
U068_RS20770	COG2224	Isocitrate lyase
U068_RS20785	COG1414	Transcriptional regulator
U068_RS20790	COG0646	methionine synthase
U068_RS20790	COG1410	methionine synthase
U068_RS20795	COG1283	sodium-dependent phosphate transmembrane transporter activity
U068_RS20805	COG1187	pseudouridine synthase activity
U068_RS20815	COG0527	aspartate kinase activity
U068_RS20840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U068_RS20860	COG2814	Major facilitator Superfamily
U068_RS20860	COG0477	Major facilitator Superfamily
U068_RS20865	COG3833	ABC-type maltose transport systems, permease component
U068_RS20870	COG1175	transmembrane transport
U068_RS20875	COG2182	Extracellular solute-binding protein
U068_RS20885	COG3842	ATPase activity
U068_RS20905	COG1357	PFAM Pentapeptide repeats (8 copies)
U068_RS20925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U068_RS20935	COG0534	Mate efflux family protein
U068_RS20940	COG3237	CsbD-like
U068_RS20945	COG0735	belongs to the Fur family
U068_RS20960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U068_RS20970	COG0604	alcohol dehydrogenase
U068_RS20975	COG0305	Participates in initiation and elongation during chromosome replication
U068_RS20980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U068_RS20985	COG1448	Aminotransferase
U068_RS20995	COG3700	Belongs to the class B bacterial acid phosphatase family
U068_RS21000	COG0432	Pfam Uncharacterised protein family UPF0047
U068_RS21005	COG2315	Protein conserved in bacteria
U068_RS21010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U068_RS21015	COG0629	single-stranded DNA binding
U068_RS21025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
U068_RS21030	COG2207	Transcriptional regulator
U068_RS21035	COG0789	Transcriptional regulator
U068_RS21040	COG2252	PERMEase
U068_RS21045	COG0025	NhaP-type Na H and K H
U068_RS21050	COG1357	PFAM Pentapeptide repeats (8 copies)
U068_RS21060	COG3162	membrane
U068_RS21065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U068_RS21075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
U068_RS21080	COG0437	4 iron, 4 sulfur cluster binding
U068_RS21085	COG3301	Polysulphide reductase, NrfD
U068_RS21090	COG1138	Cytochrome C-type biogenesis protein
U068_RS21095	COG3088	subunit of a heme lyase
U068_RS21100	COG4235	cytochrome complex assembly
U068_RS21105	COG1301	dicarboxylic acid transport
U068_RS21110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
U068_RS21115	COG3383	formate dehydrogenase (NAD+) activity
U068_RS21120	COG3383	formate dehydrogenase (NAD+) activity
U068_RS21125	COG1538	Outer membrane efflux protein
U068_RS21130	COG1289	transmembrane transporter activity
U068_RS21135	COG1566	PFAM secretion protein HlyD family protein
U068_RS21145	COG2015	COG2015, Alkyl sulfatase and related hydrolases
U068_RS21150	COG1940	carbohydrate kinase activity
U068_RS21155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U068_RS21160	COG1172	Belongs to the binding-protein-dependent transport system permease family
U068_RS21165	COG1129	ABC transporter
U068_RS21170	COG1879	ABC-type sugar transport system periplasmic component
U068_RS21175	COG1737	Transcriptional regulator
U068_RS21180	COG0698	ribose 5-phosphate isomerase
U068_RS21190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
U068_RS21195	COG0456	acetyltransferase
U068_RS21200	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
U068_RS21205	COG3454	Phosphonate metabolism
U068_RS21210	COG4778	phosphonate C-P lyase system protein PhnL
U068_RS21215	COG4107	phosphonate C-P lyase system protein PhnK
U068_RS21220	COG3627	carbon phosphorus lyase activity
U068_RS21225	COG3626	phosphonate metabolism
U068_RS21230	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
U068_RS21235	COG3624	Phosphonate C-P lyase system protein PhnG
U068_RS21240	COG2188	Transcriptional regulator
U068_RS21250	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
U068_RS21255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
U068_RS21260	COG2764	glyoxalase bleomycin resistance protein dioxygenase
U068_RS21265	COG2824	Alkylphosphonate utilization operon protein PhnA
U068_RS21270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
U068_RS21280	COG0477	Major facilitator Superfamily
U068_RS21290	COG0642	Histidine kinase
U068_RS21295	COG0745	RESPONSE REGULATOR receiver
U068_RS21300	COG2194	sulfuric ester hydrolase activity
U068_RS21305	COG0531	amino acid
U068_RS21310	COG2207	Transcriptional regulator
U068_RS21315	COG1982	Orn Lys Arg decarboxylase major
U068_RS21320	COG2169	Transcriptional regulator
U068_RS21330	COG1486	melibiose metabolic process
U068_RS21335	COG2211	Major facilitator Superfamily
U068_RS21340	COG3647	Membrane
U068_RS21345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
U068_RS21345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
U068_RS21350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U068_RS21360	COG4565	transcriptional regulatory protein
U068_RS21365	COG3290	protein histidine kinase activity
U068_RS21370	COG3592	Divergent 4Fe-4S mono-cluster
U068_RS21375	COG2388	GCN5-related N-acetyl-transferase
U068_RS21390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U068_RS21395	COG3104	oligopeptide transport
U068_RS21400	COG1982	Orn Lys Arg decarboxylase major
U068_RS21405	COG0531	amino acid
U068_RS21410	COG3710	Transcriptional regulator
U068_RS21420	COG1309	transcriptional regulator
U068_RS21425	COG4232	protein-disulfide reductase activity
U068_RS21435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
U068_RS21440	COG1027	Aspartate ammonia-lyase
U068_RS21445	COG3030	protein affecting phage T7 exclusion by the F plasmid
U068_RS21450	COG0531	amino acid
U068_RS21475	COG1509	lysine 2,3-aminomutase activity
U068_RS21485	COG5510	response to toxic substance
U068_RS21490	COG5510	response to toxic substance
U068_RS21495	COG2076	Multidrug Resistance protein
U068_RS21500	COG3040	lipid binding
U068_RS21505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U068_RS21520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U068_RS21525	COG1053	succinate dehydrogenase
U068_RS21535	COG0531	amino acid
U068_RS21550	COG1511	domain protein
U068_RS21550	COG3264	Mechanosensitive ion channel
U068_RS21585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
U068_RS21590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
U068_RS21590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U068_RS21595	COG0802	atpase or kinase
U068_RS21600	COG0860	N-Acetylmuramoyl-L-alanine amidase
U068_RS21620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U068_RS21625	COG0330	HflC and HflK could
U068_RS21630	COG0330	HflC and HflK could
U068_RS21635	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
U068_RS21650	COG0557	exoribonuclease II activity
U068_RS21655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U068_RS21660	COG3789	protein conserved in bacteria
U068_RS21665	COG1842	Phage shock protein A
U068_RS21675	COG3766	membrane
U068_RS21680	COG5463	Belongs to the UPF0441 family
U068_RS21685	COG0754	glutathionylspermidine amidase activity
U068_RS21690	COG1960	acyl-CoA dehydrogenase activity
U068_RS21700	COG3650	response to hydrogen peroxide
U068_RS21705	COG1073	alpha beta
U068_RS21720	COG3037	sugar-specific permease SgaT UlaA
U068_RS21725	COG3414	Phosphotransferase system galactitol-specific IIB component
U068_RS21730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS21770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
U068_RS21785	COG1309	transcriptional regulator
U068_RS21790	COG3061	Opacity-associated protein A
U068_RS21795	COG0545	Peptidyl-prolyl cis-trans isomerase
U068_RS21800	COG1113	amino acid transport
U068_RS21810	COG0697	spore germination
U068_RS21815	COG0702	epimerase
U068_RS21820	COG1733	regulation of RNA biosynthetic process
U068_RS21825	COG0737	Belongs to the 5'-nucleotidase family
U068_RS21830	COG1218	3'(2'),5'-bisphosphate nucleotidase
U068_RS21840	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
U068_RS21850	COG1253	flavin adenine dinucleotide binding
U068_RS21865	COG0729	surface antigen
U068_RS21870	COG2911	Protein conserved in bacteria
U068_RS21875	COG2105	PFAM AIG2 family protein
U068_RS21880	COG2336	PFAM SpoVT AbrB
U068_RS21885	COG2337	Toxic component of a toxin-antitoxin (TA) module
U068_RS21890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
U068_RS21895	COG1879	ABC-type sugar transport system periplasmic component
U068_RS21900	COG1129	ABC transporter
U068_RS21905	COG1172	Belongs to the binding-protein-dependent transport system permease family
U068_RS21910	COG1172	Belongs to the binding-protein-dependent transport system permease family
U068_RS21920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U068_RS21930	COG0312	modulator of DNA gyrase
U068_RS21935	COG3783	Cytochrome b(562)
U068_RS21940	COG0602	queuosine metabolic process
U068_RS21945	COG1328	CTP reductase activity
U068_RS21950	COG0366	Alpha amylase catalytic
U068_RS21955	COG1263	PTS System
U068_RS21955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U068_RS21960	COG1609	Transcriptional regulator
U068_RS21965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U068_RS21970	COG0251	oxidation-reduction process
U068_RS21995	COG0251	oxidation-reduction process
U068_RS22000	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS22005	COG1309	transcriptional regulator
U068_RS22010	COG2731	YhcH YjgK YiaL family protein
U068_RS22020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U068_RS22025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
U068_RS22030	COG0456	acetyltransferase
U068_RS22035	COG4269	membrane
U068_RS22040	COG0525	valine-tRNA ligase activity
U068_RS22045	COG2927	DNA polymerase III (CHI subunit)
U068_RS22055	COG0795	lipopolysaccharide-transporting ATPase activity
U068_RS22060	COG0795	lipopolysaccharide-transporting ATPase activity
U068_RS22065	COG0433	COG0433 Predicted ATPase
U068_RS22070	COG1609	Transcriptional regulator
U068_RS22075	COG2610	gluconate transmembrane transporter activity
U068_RS22080	COG1028	Short-chain dehydrogenase reductase Sdr
U068_RS22085	COG1063	alcohol dehydrogenase
U068_RS22090	COG3265	gluconokinase activity
U068_RS22095	COG1064	alcohol dehydrogenase
U068_RS22105	COG0582	viral genome integration into host DNA
U068_RS22140	COG3385	transposase activity
U068_RS22145	COG2814	Major facilitator Superfamily
U068_RS22150	COG0673	inositol 2-dehydrogenase activity
U068_RS22170	COG2826	transposase and inactivated derivatives, IS30 family
U068_RS22185	COG2085	NADP oxidoreductase coenzyme F420-dependent
U068_RS22190	COG1120	ATPase activity
U068_RS22195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U068_RS22200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U068_RS22205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
U068_RS22210	COG4772	TonB-dependent receptor
U068_RS22215	COG3712	iron ion homeostasis
U068_RS22220	COG1595	DNA-templated transcription, initiation
U068_RS22240	COG2390	Transcriptional regulator
U068_RS22250	COG2610	gluconate transmembrane transporter activity
U068_RS22255	COG0129	dihydroxy-acid dehydratase activity
U068_RS22260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U068_RS22265	COG1414	Transcriptional regulator
U068_RS22270	COG1349	DNA-binding transcription factor activity
U068_RS22275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U068_RS22280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U068_RS22285	COG0434	BtpA family
U068_RS22290	COG3775	system Galactitol-specific IIC component
U068_RS22295	COG3414	Phosphotransferase system galactitol-specific IIB component
U068_RS22300	COG1363	Peptidase, m42
U068_RS22305	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
U068_RS22310	COG3153	acetyltransferase
U068_RS22330	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
U068_RS22330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U068_RS22340	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
U068_RS22345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
U068_RS22360	COG0582	viral genome integration into host DNA
U068_RS22365	COG4974	Belongs to the 'phage' integrase family
U068_RS22375	COG3539	Fimbrial protein
U068_RS22380	COG3539	Fimbrial protein
U068_RS22385	COG3121	Chaperone
U068_RS22390	COG3188	usher protein
U068_RS22395	COG3539	Fimbrial protein
U068_RS22400	COG3539	Fimbrial protein
U068_RS22405	COG3539	Fimbrial protein
U068_RS22410	COG2610	gluconate transmembrane transporter activity
U068_RS22425	COG0246	Mannitol dehydrogenase
U068_RS22435	COG2186	Transcriptional regulator
U068_RS22460	COG0583	DNA-binding transcription factor activity
U068_RS22465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U068_RS22470	COG0700	Nucleoside recognition
U068_RS22475	COG3366	ferrous iron transmembrane transporter activity
U068_RS22485	COG0477	Major facilitator Superfamily
U068_RS22490	COG3204	pilus organization
U068_RS22500	COG1924	4 iron, 4 sulfur cluster binding
U068_RS22505	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
U068_RS22510	COG2733	membrane
U068_RS22515	COG2814	Major facilitator Superfamily
U068_RS22525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U068_RS22530	COG5457	Domain of unknown function (DUF1127)
U068_RS22535	COG1196	nuclear chromosome segregation
U068_RS22545	COG4268	DNA restriction-modification system
U068_RS22550	COG1401	restriction endodeoxyribonuclease activity
U068_RS22560	COG0732	type I restriction modification DNA specificity domain
U068_RS22565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
U068_RS22570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
U068_RS22575	COG1715	Restriction endonuclease
U068_RS22580	COG0523	cobalamin synthesis protein
U068_RS22585	COG2879	small protein
U068_RS22590	COG1966	Carbon starvation protein
U068_RS22600	COG0840	transmembrane signaling receptor activity
U068_RS22605	COG2271	Major facilitator Superfamily
U068_RS22610	COG1802	Transcriptional regulator
U068_RS22615	COG1063	alcohol dehydrogenase
U068_RS22630	COG1484	DNA-dependent DNA replication
U068_RS22645	COG2966	Psort location CytoplasmicMembrane, score
U068_RS22650	COG2197	response regulator
U068_RS22655	COG2197	response regulator
U068_RS22660	COG4114	ferric iron reductase
U068_RS22690	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
U068_RS22695	COG0456	acetyltransferase
U068_RS22700	COG1011	Hydrolase
U068_RS22710	COG2823	Periplasmic or secreted lipoprotein
U068_RS22720	COG4667	esterase of the alpha-beta hydrolase superfamily
U068_RS22725	COG0084	hydrolase, TatD family'
U068_RS22730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
U068_RS22735	COG1328	CTP reductase activity
U068_RS22765	COG3550	peptidyl-serine autophosphorylation
U068_RS22775	COG3726	membrane protein affecting hemolysin expression
U068_RS22780	COG0560	Phosphoserine phosphatase
U068_RS22785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
U068_RS22790	COG3172	ATPase kinase involved in NAD metabolism
U068_RS22790	COG1056	cytidyltransferase-related domain
U068_RS22800	COG0488	(ABC) transporter
U068_RS22805	COG0741	lytic transglycosylase activity
U068_RS22825	COG2207	Transcriptional regulator
U068_RS22825	COG3708	Transcriptional regulator
U068_RS22830	COG3045	CreA protein
U068_RS22835	COG0745	RESPONSE REGULATOR receiver
U068_RS22840	COG2205	protein histidine kinase activity
U068_RS22845	COG4452	Inner membrane protein CreD
U068_RS22850	COG0745	RESPONSE REGULATOR receiver
U068_RS22860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA