locus-tag	class	description
NEB5A_RS00010	COG0527	aspartate kinase activity
NEB5A_RS00010	COG0460	homoserine dehydrogenase
NEB5A_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NEB5A_RS00040	COG1115	amino acid carrier protein
NEB5A_RS00045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NEB5A_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
NEB5A_RS00055	COG1584	GPR1 FUN34 yaaH family protein
NEB5A_RS00060	COG4735	regulation of single-species biofilm formation
NEB5A_RS00080	COG3385	transposase activity
NEB5A_RS00090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NEB5A_RS00095	COG0583	DNA-binding transcription factor activity
NEB5A_RS00120	COG0196	riboflavin kinase activity
NEB5A_RS00135	COG1047	Peptidyl-prolyl cis-trans
NEB5A_RS00165	COG0505	Belongs to the CarA family
NEB5A_RS00170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NEB5A_RS00225	COG0644	oxidoreductase
NEB5A_RS00230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NEB5A_RS00235	COG2271	Major facilitator Superfamily
NEB5A_RS00250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NEB5A_RS00275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NEB5A_RS00280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NEB5A_RS00285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NEB5A_RS00295	COG0564	pseudouridine synthase activity
NEB5A_RS00305	COG0417	DNA replication proofreading
NEB5A_RS00310	COG0235	Class ii aldolase
NEB5A_RS00315	COG2160	L-arabinose isomerase activity
NEB5A_RS00320	COG1069	ribulokinase activity
NEB5A_RS00325	COG4977	sequence-specific DNA binding
NEB5A_RS00330	COG0586	Pfam SNARE associated Golgi protein
NEB5A_RS00335	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NEB5A_RS00340	COG1178	ABC-type Fe3 transport system permease component
NEB5A_RS00345	COG4143	(ABC) transporter
NEB5A_RS00360	COG2814	Major facilitator Superfamily
NEB5A_RS00375	COG0473	3-isopropylmalate dehydrogenase activity
NEB5A_RS00390	COG0583	DNA-binding transcription factor activity
NEB5A_RS00395	COG0028	Belongs to the TPP enzyme family
NEB5A_RS00400	COG0440	acetolactate synthase activity
NEB5A_RS00410	COG1609	Transcriptional regulator
NEB5A_RS00415	COG2001	Belongs to the MraZ family
NEB5A_RS00425	COG3116	cell division
NEB5A_RS00430	COG0768	penicillin binding
NEB5A_RS00435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NEB5A_RS00440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NEB5A_RS00450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NEB5A_RS00455	COG0772	Belongs to the SEDS family
NEB5A_RS00470	COG1181	Belongs to the D-alanine--D-alanine ligase family
NEB5A_RS00475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NEB5A_RS00480	COG0849	cell division
NEB5A_RS00485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NEB5A_RS00505	COG0494	nUDIX hydrolase
NEB5A_RS00525	COG0237	dephospho-CoA kinase activity
NEB5A_RS00535	COG1459	type II secretion system
NEB5A_RS00540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NEB5A_RS00545	COG4969	Belongs to the N-Me-Phe pilin family
NEB5A_RS00555	COG0157	Belongs to the NadC ModD family
NEB5A_RS00560	COG3023	N-Acetylmuramoyl-L-alanine amidase
NEB5A_RS00565	COG3725	Membrane protein required for beta-lactamase induction
NEB5A_RS00570	COG1113	amino acid transport
NEB5A_RS00575	COG2186	Transcriptional regulator
NEB5A_RS00580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NEB5A_RS00585	COG0508	dehydrogenase complex catalyzes the overall conversion of
NEB5A_RS00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEB5A_RS00595	COG3064	Membrane
NEB5A_RS00600	COG1049	propionate catabolic process, 2-methylcitrate cycle
NEB5A_RS00625	COG2132	Multicopper oxidase
NEB5A_RS00630	COG4993	Dehydrogenase
NEB5A_RS00635	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NEB5A_RS00640	COG0288	reversible hydration of carbon dioxide
NEB5A_RS00645	COG1131	(ABC) transporter
NEB5A_RS00650	COG0842	Transport permease protein
NEB5A_RS00655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS00660	COG0726	polysaccharide deacetylase
NEB5A_RS00670	COG5464	transposase or invertase
NEB5A_RS00685	COG3539	Fimbrial protein
NEB5A_RS00690	COG3539	Fimbrial protein
NEB5A_RS00695	COG3539	Fimbrial protein
NEB5A_RS00700	COG3539	Fimbrial protein
NEB5A_RS00705	COG3188	usher protein
NEB5A_RS00710	COG3121	Chaperone
NEB5A_RS00715	COG3539	Fimbrial protein
NEB5A_RS00720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NEB5A_RS00725	COG0617	tRNA 3'-terminal CCA addition
NEB5A_RS00735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NEB5A_RS00745	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NEB5A_RS00750	COG1643	Atp-dependent helicase
NEB5A_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NEB5A_RS00765	COG4774	siderophore transport
NEB5A_RS00775	COG4774	siderophore transport
NEB5A_RS00780	COG1120	ATPase activity
NEB5A_RS00785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NEB5A_RS00790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEB5A_RS00810	COG2860	membrane
NEB5A_RS00815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NEB5A_RS00830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEB5A_RS00835	COG3835	regulator
NEB5A_RS00845	COG1408	metallophosphoesterase
NEB5A_RS00860	COG0024	Methionine aminopeptidase
NEB5A_RS00885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NEB5A_RS00890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NEB5A_RS00895	COG0575	Belongs to the CDS family
NEB5A_RS00900	COG0750	zinc metalloprotease
NEB5A_RS00910	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NEB5A_RS00915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NEB5A_RS00940	COG0587	DNA-directed DNA polymerase activity
NEB5A_RS00950	COG1982	Orn Lys Arg decarboxylase major
NEB5A_RS00955	COG0346	lactoylglutathione lyase activity
NEB5A_RS00960	COG0037	tRNA processing
NEB5A_RS00965	COG4568	rho-dependent transcription termination
NEB5A_RS00975	COG4681	YaeQ
NEB5A_RS00980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NEB5A_RS00985	COG3015	lipoprotein NlpE involved in copper resistance
NEB5A_RS00990	COG0791	NLP P60 protein
NEB5A_RS01000	COG1720	tRNA m6t6A37 methyltransferase activity
NEB5A_RS01010	COG1464	Belongs to the NlpA lipoprotein family
NEB5A_RS01015	COG2011	ABC-type metal ion transport system permease component
NEB5A_RS01020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NEB5A_RS01025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NEB5A_RS01060	COG0656	L-ascorbic acid biosynthetic process
NEB5A_RS01065	COG0583	DNA-binding transcription factor activity
NEB5A_RS01075	COG2226	methyltransferase
NEB5A_RS01080	COG0741	lytic transglycosylase activity
NEB5A_RS01080	COG1388	LysM domain
NEB5A_RS01090	COG2226	methyltransferase
NEB5A_RS01100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEB5A_RS01120	COG4104	PAAR repeat-containing protein
NEB5A_RS01125	COG5433	transposase activity
NEB5A_RS01130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NEB5A_RS01140	COG1960	acyl-CoA dehydrogenase activity
NEB5A_RS01150	COG0121	glutamine amidotransferase
NEB5A_RS01155	COG3034	peptidoglycan biosynthetic process
NEB5A_RS01160	COG3041	Addiction module toxin RelE StbE family
NEB5A_RS01165	COG3077	Addiction module antitoxin, RelB DinJ family
NEB5A_RS01170	COG0791	NLP P60 protein
NEB5A_RS01175	COG1943	Transposase
NEB5A_RS01195	COG2161	toxin-antitoxin pair type II binding
NEB5A_RS01205	COG0454	-acetyltransferase
NEB5A_RS01210	COG1690	Belongs to the RtcB family
NEB5A_RS01215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NEB5A_RS01220	COG2195	Cleaves the N-terminal amino acid of tripeptides
NEB5A_RS01245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NEB5A_RS01260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NEB5A_RS01290	COG2003	Belongs to the UPF0758 family
NEB5A_RS01310	COG2378	regulation of single-species biofilm formation
NEB5A_RS01325	COG3596	GTP binding
NEB5A_RS01330	COG0583	DNA-binding transcription factor activity
NEB5A_RS01335	COG2963	transposase activity
NEB5A_RS01340	COG2826	transposase and inactivated derivatives, IS30 family
NEB5A_RS01345	COG2801	Transposase and inactivated derivatives
NEB5A_RS01360	COG3344	reverse transcriptase
NEB5A_RS01370	COG3971	2-oxopent-4-enoate hydratase activity
NEB5A_RS01385	COG2814	Major facilitator Superfamily
NEB5A_RS01390	COG3122	Protein conserved in bacteria
NEB5A_RS01400	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NEB5A_RS01435	COG1215	transferase activity, transferring glycosyl groups
NEB5A_RS01440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NEB5A_RS01445	COG4521	taurine ABC transporter
NEB5A_RS01455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NEB5A_RS01460	COG2175	clavaminate synthase activity
NEB5A_RS01465	COG0113	porphobilinogen synthase activity
NEB5A_RS01475	COG2801	Transposase and inactivated derivatives
NEB5A_RS01485	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS01490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEB5A_RS01495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEB5A_RS01505	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NEB5A_RS01525	COG1181	Belongs to the D-alanine--D-alanine ligase family
NEB5A_RS01540	COG1785	Belongs to the alkaline phosphatase family
NEB5A_RS01550	COG3706	GGDEF domain
NEB5A_RS01555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NEB5A_RS01580	COG4126	flavin adenine dinucleotide binding
NEB5A_RS01600	COG1940	carbohydrate kinase activity
NEB5A_RS01605	COG2814	Major facilitator Superfamily
NEB5A_RS01610	COG0419	ATPase involved in DNA repair
NEB5A_RS01615	COG0420	3'-5' exonuclease activity
NEB5A_RS01620	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS01625	COG5002	protein histidine kinase activity
NEB5A_RS01630	COG1114	Component of the transport system for branched-chain amino acids
NEB5A_RS01635	COG1113	amino acid transport
NEB5A_RS01640	COG0366	Alpha amylase catalytic
NEB5A_RS01660	COG1862	Preprotein translocase
NEB5A_RS01665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NEB5A_RS01670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NEB5A_RS01675	COG1403	HNH endonuclease
NEB5A_RS01685	COG3248	Nucleoside-binding outer membrane protein
NEB5A_RS01690	COG4238	major outer membrane lipoprotein
NEB5A_RS01700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NEB5A_RS01700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NEB5A_RS01715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NEB5A_RS01720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NEB5A_RS01725	COG0667	Aldo Keto reductase
NEB5A_RS01735	COG0142	geranyltranstransferase activity
NEB5A_RS01750	COG0693	protein deglycase activity
NEB5A_RS01755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NEB5A_RS01765	COG2814	Major facilitator Superfamily
NEB5A_RS01775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NEB5A_RS01780	COG1845	cytochrome c oxidase, subunit III
NEB5A_RS01785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NEB5A_RS01790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NEB5A_RS01795	COG2223	nitrite transmembrane transporter activity
NEB5A_RS01800	COG3056	Lipoprotein
NEB5A_RS01805	COG0271	Belongs to the BolA IbaG family
NEB5A_RS01830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NEB5A_RS01835	COG0776	regulation of translation
NEB5A_RS01840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NEB5A_RS01845	COG1555	photosystem II stabilization
NEB5A_RS01850	COG0824	Thioesterase
NEB5A_RS01860	COG4533	DNA binding
NEB5A_RS01870	COG1522	sequence-specific DNA binding
NEB5A_RS01875	COG1132	(ABC) transporter
NEB5A_RS01880	COG1132	(ABC) transporter
NEB5A_RS01885	COG0347	Belongs to the P(II) protein family
NEB5A_RS01890	COG0004	ammonium transporteR
NEB5A_RS01895	COG1946	Acyl-CoA thioesterase
NEB5A_RS01900	COG3126	Type III secretion system lipoprotein chaperone (YscW)
NEB5A_RS01905	COG3695	enzyme binding
NEB5A_RS01915	COG5507	3-demethylubiquinone-9 3-methyltransferase
NEB5A_RS01920	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NEB5A_RS01930	COG0110	maltose O-acetyltransferase activity
NEB5A_RS01945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEB5A_RS01950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS01955	COG1309	transcriptional regulator
NEB5A_RS01960	COG1196	nuclear chromosome segregation
NEB5A_RS01960	COG3264	Mechanosensitive ion channel
NEB5A_RS01975	COG3923	Primosomal replication protein n
NEB5A_RS01980	COG2832	Protein of unknown function (DUF454)
NEB5A_RS01990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NEB5A_RS02025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS02030	COG4651	solute:proton antiporter activity
NEB5A_RS02030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NEB5A_RS02035	COG2223	nitrite transmembrane transporter activity
NEB5A_RS02040	COG0737	Belongs to the 5'-nucleotidase family
NEB5A_RS02045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NEB5A_RS02050	COG3735	TraB family
NEB5A_RS02055	COG3093	addiction module antidote protein HigA
NEB5A_RS02060	COG2217	Heavy metal translocating P-type atpase
NEB5A_RS02065	COG2066	Belongs to the glutaminase family
NEB5A_RS02070	COG0531	amino acid
NEB5A_RS02075	COG0789	Transcriptional regulator
NEB5A_RS02080	COG1585	Membrane protein implicated in regulation of membrane protease activity
NEB5A_RS02085	COG0330	HflC and HflK could
NEB5A_RS02090	COG4619	ABC transporter
NEB5A_RS02095	COG0390	transport system, permease component
NEB5A_RS02100	COG3118	belongs to the thioredoxin family
NEB5A_RS02105	COG0300	oxidoreductase activity
NEB5A_RS02110	COG2755	lipolytic protein G-D-S-L family
NEB5A_RS02115	COG4181	ATPase activity
NEB5A_RS02120	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NEB5A_RS02125	COG3209	COG3209 Rhs family protein
NEB5A_RS02135	COG3209	COG3209 Rhs family protein
NEB5A_RS02145	COG2801	Transposase and inactivated derivatives
NEB5A_RS02155	COG0583	DNA-binding transcription factor activity
NEB5A_RS02165	COG1414	Transcriptional regulator
NEB5A_RS02170	COG3960	tartronate-semialdehyde synthase activity
NEB5A_RS02175	COG3622	Belongs to the hyi family
NEB5A_RS02180	COG2084	Dehydrogenase
NEB5A_RS02185	COG1953	Uracil, thiamine, allantoin
NEB5A_RS02195	COG2233	PERMEase
NEB5A_RS02200	COG1929	Belongs to the glycerate kinase type-1 family
NEB5A_RS02205	COG3257	ureidoglycine aminohydrolase activity
NEB5A_RS02210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEB5A_RS02215	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NEB5A_RS02220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NEB5A_RS02225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NEB5A_RS02235	COG0549	Belongs to the carbamate kinase family
NEB5A_RS02240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NEB5A_RS02245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NEB5A_RS02255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NEB5A_RS02265	COG1988	membrane-bound metal-dependent
NEB5A_RS02270	COG2501	S4 domain
NEB5A_RS02280	COG3539	Fimbrial protein
NEB5A_RS02285	COG3121	Chaperone
NEB5A_RS02290	COG3188	usher protein
NEB5A_RS02295	COG3539	Fimbrial protein
NEB5A_RS02300	COG3539	Fimbrial protein
NEB5A_RS02305	COG2197	response regulator
NEB5A_RS02315	COG0582	viral genome integration into host DNA
NEB5A_RS02335	COG3772	lysozyme
NEB5A_RS02350	COG5562	phage envelope protein
NEB5A_RS02365	COG4220	transposase activity
NEB5A_RS02375	COG0500	methyltransferase
NEB5A_RS02385	COG2207	Transcriptional regulator
NEB5A_RS02390	COG4571	Outer membrane protease
NEB5A_RS02400	COG2207	Transcriptional regulator
NEB5A_RS02410	COG4783	chaperone-mediated protein folding
NEB5A_RS02415	COG1215	transferase activity, transferring glycosyl groups
NEB5A_RS02420	COG5002	protein histidine kinase activity
NEB5A_RS02425	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS02430	COG1538	Outer membrane efflux protein
NEB5A_RS02435	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS02445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEB5A_RS02450	COG1113	amino acid transport
NEB5A_RS02455	COG0668	transmembrane transport
NEB5A_RS02460	COG0778	Nitroreductase
NEB5A_RS02465	COG2315	Protein conserved in bacteria
NEB5A_RS02490	COG3385	transposase activity
NEB5A_RS02495	COG2977	Belongs to the P-Pant transferase superfamily
NEB5A_RS02500	COG4771	TonB-dependent receptor
NEB5A_RS02505	COG2382	esterase
NEB5A_RS02510	COG3251	PFAM MbtH domain protein
NEB5A_RS02515	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NEB5A_RS02515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NEB5A_RS02520	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
NEB5A_RS02525	COG1120	ATPase activity
NEB5A_RS02530	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEB5A_RS02535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEB5A_RS02545	COG4592	Periplasmic binding protein
NEB5A_RS02550	COG1169	isochorismate synthase
NEB5A_RS02555	COG1021	2,3-dihydroxybenzoate-AMP ligase
NEB5A_RS02560	COG3433	isochorismatase activity
NEB5A_RS02560	COG1535	isochorismatase
NEB5A_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS02570	COG2050	protein possibly involved in aromatic compounds catabolism
NEB5A_RS02575	COG1966	Carbon starvation protein
NEB5A_RS02580	COG2879	small protein
NEB5A_RS02585	COG0371	Dehydrogenase
NEB5A_RS02590	COG0436	Aminotransferase
NEB5A_RS02595	COG1475	DNA binding
NEB5A_RS02600	COG3969	phosphoadenosine phosphosulfate
NEB5A_RS02605	COG0583	DNA-binding transcription factor activity
NEB5A_RS02610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NEB5A_RS02615	COG0450	alkyl hydroperoxide reductase
NEB5A_RS02620	COG3634	alkyl hydroperoxide reductase activity
NEB5A_RS02625	COG0589	response to stress
NEB5A_RS02630	COG1063	alcohol dehydrogenase
NEB5A_RS02640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NEB5A_RS02645	COG3719	Belongs to the RNase T2 family
NEB5A_RS02650	COG0471	metal ion transport
NEB5A_RS02665	COG3051	citrate lyase alpha subunit
NEB5A_RS02670	COG2301	Belongs to the HpcH HpaI aldolase family
NEB5A_RS02680	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NEB5A_RS02685	COG3290	protein histidine kinase activity
NEB5A_RS02690	COG4565	transcriptional regulatory protein
NEB5A_RS02695	COG3069	C4-dicarboxylate transmembrane transporter activity
NEB5A_RS02720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEB5A_RS02730	COG0583	DNA-binding transcription factor activity
NEB5A_RS02750	COG1686	Belongs to the peptidase S11 family
NEB5A_RS02755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NEB5A_RS02760	COG0772	Belongs to the SEDS family
NEB5A_RS02765	COG0768	penicillin binding
NEB5A_RS02775	COG0799	negative regulation of ribosome biogenesis
NEB5A_RS02780	COG0406	alpha-ribazole phosphatase activity
NEB5A_RS02790	COG1466	dna polymerase III delta subunit
NEB5A_RS02805	COG2888	peptidyl-tyrosine sulfation
NEB5A_RS02810	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NEB5A_RS02820	COG2214	Heat shock protein DnaJ domain protein
NEB5A_RS02825	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NEB5A_RS02835	COG2214	Heat shock protein DnaJ domain protein
NEB5A_RS02840	COG0443	Heat shock 70 kDa protein
NEB5A_RS02850	COG1126	abc transporter atp-binding protein
NEB5A_RS02855	COG0765	amino acid transport
NEB5A_RS02860	COG0765	amino acid transport
NEB5A_RS02865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS02875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NEB5A_RS02880	COG4535	Mg2 and Co2 transporter CorC
NEB5A_RS02890	COG1702	phosphate starvation-inducible protein PhoH
NEB5A_RS02900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEB5A_RS02935	COG0367	asparagine synthase
NEB5A_RS02940	COG0647	UMP catabolic process
NEB5A_RS02945	COG1846	Transcriptional regulator
NEB5A_RS02945	COG1940	carbohydrate kinase activity
NEB5A_RS02950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NEB5A_RS02960	COG1263	PTS System
NEB5A_RS02960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS02960	COG2190	(PTS) system
NEB5A_RS02980	COG0735	belongs to the Fur family
NEB5A_RS02995	COG0716	FMN binding
NEB5A_RS03005	COG0596	Alpha beta hydrolase
NEB5A_RS03010	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NEB5A_RS03015	COG0033	Phosphoglucomutase
NEB5A_RS03035	COG0531	amino acid
NEB5A_RS03040	COG1982	Orn Lys Arg decarboxylase major
NEB5A_RS03050	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS03055	COG2205	protein histidine kinase activity
NEB5A_RS03085	COG3209	COG3209 Rhs family protein
NEB5A_RS03095	COG3209	COG3209 Rhs family protein
NEB5A_RS03105	COG5433	transposase activity
NEB5A_RS03115	COG5433	transposase activity
NEB5A_RS03120	COG3272	Protein of unknown function (DUF1722)
NEB5A_RS03125	COG0415	Belongs to the DNA photolyase family
NEB5A_RS03130	COG3104	oligopeptide transport
NEB5A_RS03135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NEB5A_RS03140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NEB5A_RS03145	COG1984	allophanate hydrolase subunit 2
NEB5A_RS03160	COG3180	Ammonia monooxygenase
NEB5A_RS03165	COG3539	Fimbrial protein
NEB5A_RS03170	COG3121	Chaperone
NEB5A_RS03175	COG3188	usher protein
NEB5A_RS03180	COG3539	Fimbrial protein
NEB5A_RS03185	COG0372	Belongs to the citrate synthase family
NEB5A_RS03195	COG2009	succinate dehydrogenase
NEB5A_RS03200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NEB5A_RS03205	COG1053	succinate dehydrogenase
NEB5A_RS03210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NEB5A_RS03220	COG0567	Dehydrogenase, E1 component
NEB5A_RS03225	COG0508	dehydrogenase complex catalyzes the overall conversion of
NEB5A_RS03235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NEB5A_RS03240	COG2188	Transcriptional regulator
NEB5A_RS03245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS03245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS03245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS03250	COG0383	alpha-mannosidase activity
NEB5A_RS03260	COG1271	oxidase subunit
NEB5A_RS03265	COG1294	oxidase, subunit
NEB5A_RS03270	COG4890	Cyd operon protein YbgT
NEB5A_RS03275	COG3790	cyd operon protein YbgE
NEB5A_RS03280	COG0824	Thioesterase
NEB5A_RS03285	COG0811	peptide transport
NEB5A_RS03290	COG0848	biopolymer transport protein
NEB5A_RS03295	COG3064	Membrane
NEB5A_RS03305	COG2885	chlorophyll binding
NEB5A_RS03310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NEB5A_RS03380	COG3201	nicotinamide mononucleotide transporter
NEB5A_RS03385	COG1230	cation diffusion facilitator family transporter
NEB5A_RS03400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NEB5A_RS03410	COG2017	converts alpha-aldose to the beta-anomer
NEB5A_RS03420	COG1085	galactose-1-phosphate uridylyltransferase
NEB5A_RS03425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NEB5A_RS03430	COG1119	ATPase activity
NEB5A_RS03435	COG3585	molybdate ion transport
NEB5A_RS03435	COG2005	Transcriptional regulator
NEB5A_RS03445	COG0725	ABC transporter, periplasmic molybdate-binding protein
NEB5A_RS03450	COG4149	molybdate abc transporter
NEB5A_RS03455	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NEB5A_RS03460	COG0561	phosphatase activity
NEB5A_RS03470	COG0583	DNA-binding transcription factor activity
NEB5A_RS03475	COG2828	Protein conserved in bacteria
NEB5A_RS03480	COG0471	metal ion transport
NEB5A_RS03485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NEB5A_RS03490	COG4677	pectinesterase activity
NEB5A_RS03495	COG1881	PFAM PEBP family protein
NEB5A_RS03500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NEB5A_RS03515	COG2226	methyltransferase
NEB5A_RS03520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NEB5A_RS03530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NEB5A_RS03540	COG0521	Mo-molybdopterin cofactor biosynthetic process
NEB5A_RS03550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NEB5A_RS03555	COG0314	molybdopterin synthase activity
NEB5A_RS03560	COG0670	Belongs to the BI1 family
NEB5A_RS03565	COG0670	Belongs to the BI1 family
NEB5A_RS03570	COG0392	lysyltransferase activity
NEB5A_RS03575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NEB5A_RS03580	COG3568	Endonuclease Exonuclease Phosphatase
NEB5A_RS03590	COG0842	Transport permease protein
NEB5A_RS03595	COG0842	Transport permease protein
NEB5A_RS03600	COG1131	(ABC) transporter
NEB5A_RS03610	COG1309	transcriptional regulator
NEB5A_RS03615	COG0513	Belongs to the DEAD box helicase family
NEB5A_RS03620	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
NEB5A_RS03625	COG1199	ATP-dependent helicase activity
NEB5A_RS03630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NEB5A_RS03635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NEB5A_RS03645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NEB5A_RS03655	COG4774	siderophore transport
NEB5A_RS03670	COG0668	transmembrane transport
NEB5A_RS03675	COG1126	abc transporter atp-binding protein
NEB5A_RS03680	COG0765	amino acid transport
NEB5A_RS03685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS03700	COG5006	permease, DMT superfamily
NEB5A_RS03705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NEB5A_RS03710	COG2194	sulfuric ester hydrolase activity
NEB5A_RS03720	COG1321	iron dependent repressor
NEB5A_RS03725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NEB5A_RS03730	COG1376	ErfK ybiS ycfS ynhG family protein
NEB5A_RS03735	COG0488	(ABC) transporter
NEB5A_RS03745	COG0561	phosphatase activity
NEB5A_RS03750	COG1882	Formate acetyltransferase
NEB5A_RS03755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NEB5A_RS03760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NEB5A_RS03765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NEB5A_RS03770	COG0303	'Molybdopterin
NEB5A_RS03775	COG1446	asparaginase
NEB5A_RS03780	COG4172	Belongs to the ABC transporter superfamily
NEB5A_RS03785	COG0747	negative chemotaxis
NEB5A_RS03795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEB5A_RS03800	COG2200	EAL domain
NEB5A_RS03805	COG2199	diguanylate cyclase activity
NEB5A_RS03820	COG2133	pyrroloquinoline quinone binding
NEB5A_RS03825	COG0625	glutathione transferase activity
NEB5A_RS03830	COG1686	Belongs to the peptidase S11 family
NEB5A_RS03835	COG1349	DNA-binding transcription factor activity
NEB5A_RS03840	COG0671	phosphoesterase, PA-phosphatase related
NEB5A_RS03845	COG2814	Major facilitator Superfamily
NEB5A_RS03855	COG0561	phosphatase activity
NEB5A_RS03860	COG0738	Major facilitator superfamily
NEB5A_RS03865	COG3226	Transcriptional regulator
NEB5A_RS03880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NEB5A_RS03890	COG0778	Nitroreductase
NEB5A_RS03910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NEB5A_RS03915	COG3842	ATPase activity
NEB5A_RS03920	COG1176	ABC-type spermidine putrescine transport system, permease component I
NEB5A_RS03925	COG1177	transmembrane transport
NEB5A_RS03940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS03945	COG4160	amino acid transport
NEB5A_RS03950	COG4215	(ABC) transporter
NEB5A_RS03955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS03960	COG1126	abc transporter atp-binding protein
NEB5A_RS03975	COG3023	N-Acetylmuramoyl-L-alanine amidase
NEB5A_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEB5A_RS03985	COG0702	epimerase
NEB5A_RS03990	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
NEB5A_RS03995	COG0028	Belongs to the TPP enzyme family
NEB5A_RS04000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEB5A_RS04010	COG2431	L-lysine efflux transmembrane transporter activity
NEB5A_RS04025	COG3593	DNA synthesis involved in DNA repair
NEB5A_RS04030	COG2990	Protein conserved in bacteria
NEB5A_RS04035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS04040	COG1136	(ABC) transporter
NEB5A_RS04040	COG0577	efflux transmembrane transporter activity
NEB5A_RS04045	COG1278	Cold shock
NEB5A_RS04055	COG0542	response to heat
NEB5A_RS04075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NEB5A_RS04080	COG4988	ABC transporter
NEB5A_RS04085	COG0492	ferredoxin-NADP+ reductase activity
NEB5A_RS04090	COG1522	sequence-specific DNA binding
NEB5A_RS04095	COG1674	ftsk spoiiie
NEB5A_RS04095	COG1178	ABC-type Fe3 transport system permease component
NEB5A_RS04105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NEB5A_RS04115	COG0243	molybdopterin cofactor binding
NEB5A_RS04120	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS04125	COG3302	dmso reductase anchor subunit
NEB5A_RS04130	COG1335	isochorismatase
NEB5A_RS04140	COG0531	amino acid
NEB5A_RS04145	COG0583	DNA-binding transcription factor activity
NEB5A_RS04150	COG2249	NAD(P)H dehydrogenase (quinone) activity
NEB5A_RS04155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NEB5A_RS04160	COG1882	Formate acetyltransferase
NEB5A_RS04165	COG2116	formate transmembrane transporter activity
NEB5A_RS04170	COG1944	ATP diphosphatase activity
NEB5A_RS04175	COG2323	membrane
NEB5A_RS04190	COG0501	Belongs to the peptidase M48B family
NEB5A_RS04200	COG0539	negative regulation of cytoplasmic translation
NEB5A_RS04210	COG0658	competence protein
NEB5A_RS04210	COG2333	competence protein COMEC
NEB5A_RS04215	COG1132	(ABC) transporter
NEB5A_RS04220	COG1663	tetraacyldisaccharide 4'-kinase activity
NEB5A_RS04225	COG3214	Protein conserved in bacteria
NEB5A_RS04240	COG3173	Aminoglycoside phosphotransferase
NEB5A_RS04245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NEB5A_RS04250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NEB5A_RS04260	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NEB5A_RS04270	COG2989	Protein conserved in bacteria
NEB5A_RS04275	COG3108	Peptidase M15
NEB5A_RS04280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NEB5A_RS04285	COG1448	Aminotransferase
NEB5A_RS04310	COG0308	aminopeptidase N
NEB5A_RS04315	COG1116	anion transmembrane transporter activity
NEB5A_RS04320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NEB5A_RS04330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NEB5A_RS04335	COG0431	NADPH-dependent FMN reductase
NEB5A_RS04340	COG3539	Fimbrial protein
NEB5A_RS04345	COG3121	Chaperone
NEB5A_RS04350	COG3188	usher protein
NEB5A_RS04355	COG3539	Fimbrial protein
NEB5A_RS04360	COG3539	Fimbrial protein
NEB5A_RS04365	COG3539	Fimbrial protein
NEB5A_RS04370	COG3121	Chaperone
NEB5A_RS04385	COG3217	Mosc domain protein beta barrel domain protein
NEB5A_RS04385	COG0633	Ferredoxin
NEB5A_RS04395	COG0488	(ABC) transporter
NEB5A_RS04400	COG2995	paraquat-inducible protein a
NEB5A_RS04405	COG3008	intermembrane lipid transfer
NEB5A_RS04405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NEB5A_RS04410	COG3009	Protein conserved in bacteria
NEB5A_RS04415	COG3130	regulation of translation
NEB5A_RS04425	COG1067	ATP-dependent peptidase activity
NEB5A_RS04435	COG2885	chlorophyll binding
NEB5A_RS04435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NEB5A_RS04450	COG3070	regulator of competence-specific genes
NEB5A_RS04455	COG1289	transmembrane transporter activity
NEB5A_RS04460	COG3304	Inner membrane component domain
NEB5A_RS04465	COG0210	DNA helicase
NEB5A_RS04485	COG1832	CoA-binding protein
NEB5A_RS04500	COG1254	Belongs to the acylphosphatase family
NEB5A_RS04505	COG2920	part of a sulfur-relay system
NEB5A_RS04510	COG0670	Belongs to the BI1 family
NEB5A_RS04520	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NEB5A_RS04525	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NEB5A_RS04530	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
NEB5A_RS04535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NEB5A_RS04540	COG1999	signal sequence binding
NEB5A_RS04545	COG1773	rubredoxin
NEB5A_RS04550	COG1271	oxidase subunit
NEB5A_RS04555	COG1294	oxidase, subunit
NEB5A_RS04570	COG0489	protein tyrosine kinase activity
NEB5A_RS04570	COG3206	protein involved in exopolysaccharide biosynthesis
NEB5A_RS04575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NEB5A_RS04580	COG1596	polysaccharide export
NEB5A_RS04585	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEB5A_RS04605	COG3677	Transposase
NEB5A_RS04605	COG1662	PFAM IS1 transposase
NEB5A_RS04610	COG1662	PFAM IS1 transposase
NEB5A_RS04615	COG1278	Cold shock
NEB5A_RS04620	COG1278	Cold shock
NEB5A_RS04635	COG0348	domain, Protein
NEB5A_RS04640	COG0784	Response regulator, receiver
NEB5A_RS04640	COG2205	protein histidine kinase activity
NEB5A_RS04640	COG2198	Histidine kinase
NEB5A_RS04645	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS04650	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS04655	COG3005	denitrification pathway
NEB5A_RS04660	COG0243	molybdopterin cofactor binding
NEB5A_RS04665	COG3381	protein complex oligomerization
NEB5A_RS04705	COG3729	General stress protein
NEB5A_RS04710	COG2233	PERMEase
NEB5A_RS04745	COG1309	transcriptional regulator
NEB5A_RS04750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NEB5A_RS04750	COG0506	proline dehydrogenase activity
NEB5A_RS04750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NEB5A_RS04760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEB5A_RS04775	COG2822	iron ion transport
NEB5A_RS04780	COG2837	iron assimilation
NEB5A_RS04790	COG1702	phosphate starvation-inducible protein PhoH
NEB5A_RS04795	COG3658	cytochrome
NEB5A_RS04800	COG1215	transferase activity, transferring glycosyl groups
NEB5A_RS04805	COG1649	PFAM Uncharacterised BCR, COG1649
NEB5A_RS04805	COG0726	polysaccharide deacetylase
NEB5A_RS04810	COG0457	Tetratricopeptide repeat
NEB5A_RS04820	COG0457	Tetratricopeptide repeat
NEB5A_RS04825	COG3706	GGDEF domain
NEB5A_RS04830	COG2801	Transposase and inactivated derivatives
NEB5A_RS04885	COG3381	protein complex oligomerization
NEB5A_RS04895	COG1462	curli production assembly transport component CsgG
NEB5A_RS04910	COG2197	response regulator
NEB5A_RS04940	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NEB5A_RS04945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NEB5A_RS04970	COG2943	transferase activity, transferring hexosyl groups
NEB5A_RS04975	COG5645	(Lipo)protein
NEB5A_RS04995	COG1560	Kdo2-lipid A biosynthetic process
NEB5A_RS05005	COG2353	YceI-like domain
NEB5A_RS05010	COG3038	cytochrome b561
NEB5A_RS05045	COG2999	glutathione oxidoreductase activity
NEB5A_RS05055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEB5A_RS05065	COG0673	inositol 2-dehydrogenase activity
NEB5A_RS05070	COG0728	peptidoglycan biosynthetic process
NEB5A_RS05075	COG3418	PFAM FlgN family protein
NEB5A_RS05080	COG2747	anti-sigma28 factor FlgM
NEB5A_RS05085	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
NEB5A_RS05090	COG1815	bacterial-type flagellum-dependent cell motility
NEB5A_RS05095	COG1558	bacterial-type flagellum-dependent cell motility
NEB5A_RS05100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NEB5A_RS05105	COG1749	Flagellar hook protein flgE
NEB5A_RS05110	COG4787	bacterial-type flagellum-dependent cell motility
NEB5A_RS05115	COG4786	Flagellar basal body rod
NEB5A_RS05130	COG3951	Flagellar rod assembly protein muramidase FlgJ
NEB5A_RS05130	COG1705	Flagellar rod assembly protein muramidase FlgJ
NEB5A_RS05135	COG1256	bacterial-type flagellum assembly
NEB5A_RS05140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NEB5A_RS05145	COG1530	ribonuclease E activity
NEB5A_RS05155	COG0564	pseudouridine synthase activity
NEB5A_RS05160	COG0424	maF-like protein
NEB5A_RS05165	COG1399	metal-binding, possibly nucleic acid-binding protein
NEB5A_RS05185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NEB5A_RS05190	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS05200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEB5A_RS05205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NEB5A_RS05210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NEB5A_RS05220	COG0470	DNA polymerase III
NEB5A_RS05225	COG0084	hydrolase, TatD family'
NEB5A_RS05230	COG1263	PTS System
NEB5A_RS05230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS05235	COG4773	Receptor
NEB5A_RS05240	COG0537	adenosine 5'-monophosphoramidase activity
NEB5A_RS05245	COG5633	Lipoprotein
NEB5A_RS05250	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
NEB5A_RS05270	COG1252	NADH dehydrogenase
NEB5A_RS05275	COG3134	Outer membrane lipoprotein
NEB5A_RS05280	COG1309	transcriptional regulator
NEB5A_RS05290	COG1376	ErfK ybiS ycfS ynhG family protein
NEB5A_RS05290	COG1388	LysM domain
NEB5A_RS05295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NEB5A_RS05300	COG4763	Acyl-transferase
NEB5A_RS05305	COG4591	ABC-type transport system involved in lipoprotein release permease component
NEB5A_RS05310	COG1136	(ABC) transporter
NEB5A_RS05315	COG4591	ABC-type transport system involved in lipoprotein release permease component
NEB5A_RS05325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NEB5A_RS05330	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NEB5A_RS05340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NEB5A_RS05345	COG1177	transmembrane transport
NEB5A_RS05355	COG3842	ATPase activity
NEB5A_RS05370	COG2850	peptidyl-arginine hydroxylation
NEB5A_RS05375	COG2205	protein histidine kinase activity
NEB5A_RS05380	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS05385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NEB5A_RS05405	COG1187	pseudouridine synthase activity
NEB5A_RS05410	COG0538	isocitrate dehydrogenase activity
NEB5A_RS05415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NEB5A_RS05435	COG2801	Transposase and inactivated derivatives
NEB5A_RS05440	COG0582	viral genome integration into host DNA
NEB5A_RS05455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NEB5A_RS05460	COG4197	protein conserved in bacteria, prophage-related
NEB5A_RS05475	COG4626	Terminase
NEB5A_RS05475	COG1802	Transcriptional regulator
NEB5A_RS05485	COG4695	Portal protein
NEB5A_RS05490	COG3299	homolog of phage Mu protein gp47
NEB5A_RS05495	COG3778	Protein conserved in bacteria
NEB5A_RS05520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NEB5A_RS05525	COG1403	HNH endonuclease
NEB5A_RS05540	COG5562	phage envelope protein
NEB5A_RS05545	COG0789	Transcriptional regulator
NEB5A_RS05550	COG2200	EAL domain
NEB5A_RS05575	COG2200	EAL domain
NEB5A_RS05625	COG2894	cell division
NEB5A_RS05655	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEB5A_RS05670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NEB5A_RS05675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEB5A_RS05680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NEB5A_RS05695	COG2719	SpoVR family
NEB5A_RS05705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NEB5A_RS05715	COG1619	proteins homologs of microcin C7 resistance protein MccF
NEB5A_RS05725	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NEB5A_RS05730	COG2261	transglycosylase associated protein
NEB5A_RS05745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS05745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEB5A_RS05745	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
NEB5A_RS05750	COG1461	Dihydroxyacetone kinase
NEB5A_RS05755	COG2376	Dihydroxyacetone kinase
NEB5A_RS05760	COG3284	Transcriptional regulator
NEB5A_RS05765	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS05775	COG0012	GTP binding
NEB5A_RS05790	COG0659	secondary active sulfate transmembrane transporter activity
NEB5A_RS05795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NEB5A_RS05820	COG2890	protein-(glutamine-N5) methyltransferase activity
NEB5A_RS05825	COG3094	Invasion gene expression up-regulator, SirB
NEB5A_RS05830	COG2912	Transglutaminase-like superfamily
NEB5A_RS05855	COG0387	Pfam Sodium calcium exchanger
NEB5A_RS05860	COG4572	Cation transport regulator
NEB5A_RS05865	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NEB5A_RS05870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NEB5A_RS05875	COG4932	domain protein
NEB5A_RS05880	COG2197	response regulator
NEB5A_RS05885	COG3850	Histidine kinase
NEB5A_RS05895	COG2223	nitrite transmembrane transporter activity
NEB5A_RS05905	COG1140	nitrate reductase beta subunit
NEB5A_RS05910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NEB5A_RS05915	COG2181	nitrate reductase activity
NEB5A_RS05950	COG0788	formyltetrahydrofolate deformylase activity
NEB5A_RS05960	COG1752	Esterase of the alpha-beta hydrolase superfamily
NEB5A_RS05970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NEB5A_RS05980	COG1435	thymidine kinase activity
NEB5A_RS05985	COG1454	alcohol dehydrogenase
NEB5A_RS05985	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS05990	COG2095	MarC family integral membrane protein
NEB5A_RS06000	COG4166	transmembrane transport
NEB5A_RS06005	COG0601	transmembrane transport
NEB5A_RS06010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEB5A_RS06015	COG0444	Belongs to the ABC transporter superfamily
NEB5A_RS06020	COG4608	Belongs to the ABC transporter superfamily
NEB5A_RS06040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NEB5A_RS06185	COG3772	lysozyme
NEB5A_RS06195	COG3646	Phage regulatory protein
NEB5A_RS06215	COG4220	transposase activity
NEB5A_RS06235	COG1030	water channel activity
NEB5A_RS06255	COG2807	transmembrane transport
NEB5A_RS06260	COG0110	maltose O-acetyltransferase activity
NEB5A_RS06265	COG2223	nitrite transmembrane transporter activity
NEB5A_RS06270	COG3250	beta-galactosidase activity
NEB5A_RS06275	COG1609	Transcriptional regulator
NEB5A_RS06280	COG1414	Transcriptional regulator
NEB5A_RS06320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NEB5A_RS06325	COG2350	Protein conserved in bacteria
NEB5A_RS06330	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NEB5A_RS06335	COG1607	acyl-coa hydrolase
NEB5A_RS06350	COG3047	cAMP biosynthetic process
NEB5A_RS06355	COG3685	Protein conserved in bacteria
NEB5A_RS06360	COG3685	Protein conserved in bacteria
NEB5A_RS06365	COG3729	General stress protein
NEB5A_RS06380	COG0135	phosphoribosylanthranilate isomerase activity
NEB5A_RS06380	COG0134	indole-3-glycerol-phosphate synthase activity
NEB5A_RS06385	COG0512	Glutamine amidotransferase of anthranilate synthase
NEB5A_RS06385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NEB5A_RS06390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NEB5A_RS06395	COG0613	PHP domain protein
NEB5A_RS06400	COG0009	L-threonylcarbamoyladenylate synthase
NEB5A_RS06405	COG4907	membrane protein (DUF2207)
NEB5A_RS06410	COG1187	pseudouridine synthase activity
NEB5A_RS06415	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NEB5A_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS06430	COG0616	signal peptide processing
NEB5A_RS06445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NEB5A_RS06450	COG0583	DNA-binding transcription factor activity
NEB5A_RS06470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NEB5A_RS06480	COG0671	phosphoesterase, PA-phosphatase related
NEB5A_RS06485	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NEB5A_RS06490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NEB5A_RS06500	COG0023	Translation Initiation Factor
NEB5A_RS06510	COG1349	DNA-binding transcription factor activity
NEB5A_RS06520	COG5001	Diguanylate cyclase
NEB5A_RS06535	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEB5A_RS06535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEB5A_RS06540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NEB5A_RS06545	COG2852	Protein conserved in bacteria
NEB5A_RS06550	COG4172	Belongs to the ABC transporter superfamily
NEB5A_RS06555	COG4172	Belongs to the ABC transporter superfamily
NEB5A_RS06560	COG4171	peptide transport system, permease
NEB5A_RS06565	COG4168	peptide transport system, permease
NEB5A_RS06570	COG4166	transmembrane transport
NEB5A_RS06585	COG0531	amino acid
NEB5A_RS06590	COG0174	glutamine synthetase
NEB5A_RS06595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NEB5A_RS06600	COG1917	Cupin 2, conserved barrel domain protein
NEB5A_RS06600	COG1396	sequence-specific DNA binding
NEB5A_RS06605	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS06610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEB5A_RS06615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NEB5A_RS06620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NEB5A_RS06625	COG1842	Phage shock protein A
NEB5A_RS06635	COG1983	PspC domain protein
NEB5A_RS06645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEB5A_RS06650	COG0366	Alpha amylase catalytic
NEB5A_RS06655	COG1653	transport
NEB5A_RS06660	COG1175	transmembrane transport
NEB5A_RS06665	COG0395	ABC-type sugar transport system, permease component
NEB5A_RS06670	COG1063	alcohol dehydrogenase
NEB5A_RS06675	COG1082	Xylose isomerase domain protein TIM barrel
NEB5A_RS06680	COG0673	inositol 2-dehydrogenase activity
NEB5A_RS06685	COG1554	hydrolase, family 65, central catalytic
NEB5A_RS06690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEB5A_RS06705	COG1609	Transcriptional regulator
NEB5A_RS06710	COG3106	COG3106 Predicted ATPase
NEB5A_RS06720	COG3283	Transcriptional regulator of aromatic amino acids metabolism
NEB5A_RS06725	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NEB5A_RS06730	COG4948	Mandelate Racemase Muconate Lactonizing
NEB5A_RS06735	COG2866	Carboxypeptidase
NEB5A_RS06740	COG0702	epimerase
NEB5A_RS06745	COG1073	alpha beta
NEB5A_RS06750	COG0583	DNA-binding transcription factor activity
NEB5A_RS06760	COG4166	transmembrane transport
NEB5A_RS06765	COG0668	transmembrane transport
NEB5A_RS06775	COG3182	Iron-regulated membrane protein
NEB5A_RS06780	COG0589	response to stress
NEB5A_RS06785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEB5A_RS06795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NEB5A_RS06800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NEB5A_RS06810	COG1473	amidohydrolase
NEB5A_RS06815	COG0583	DNA-binding transcription factor activity
NEB5A_RS06825	COG2840	Smr protein MutS2
NEB5A_RS06830	COG3706	GGDEF domain
NEB5A_RS06845	COG0513	Belongs to the DEAD box helicase family
NEB5A_RS06855	COG0582	viral genome integration into host DNA
NEB5A_RS06875	COG3723	Recombinational DNA repair protein, rece pathway
NEB5A_RS06880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEB5A_RS06915	COG4197	protein conserved in bacteria, prophage-related
NEB5A_RS06925	COG3756	Protein conserved in bacteria
NEB5A_RS06930	COG1484	DNA-dependent DNA replication
NEB5A_RS06935	COG1846	Transcriptional regulator
NEB5A_RS06945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NEB5A_RS06950	COG1475	DNA binding
NEB5A_RS06965	COG1196	nuclear chromosome segregation
NEB5A_RS06975	COG3039	Transposase
NEB5A_RS06995	COG5301	cellulose 1,4-beta-cellobiosidase activity
NEB5A_RS07000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NEB5A_RS07005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NEB5A_RS07015	COG0589	response to stress
NEB5A_RS07020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NEB5A_RS07025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NEB5A_RS07025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEB5A_RS07025	COG0674	pyruvate-flavodoxin oxidoreductase activity
NEB5A_RS07025	COG1013	pyruvate-flavodoxin oxidoreductase activity
NEB5A_RS07030	COG3042	response to heat
NEB5A_RS07035	COG3187	Heat shock protein
NEB5A_RS07040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NEB5A_RS07045	COG2911	Protein conserved in bacteria
NEB5A_RS07055	COG3784	Protein of unknown function (DUF1318)
NEB5A_RS07060	COG2207	Transcriptional regulator
NEB5A_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS07070	COG3733	amine oxidase
NEB5A_RS07075	COG2030	dehydratase
NEB5A_RS07075	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS07085	COG3460	Phenylacetate-CoA oxygenase
NEB5A_RS07090	COG3396	Phenylacetate-CoA oxygenase
NEB5A_RS07095	COG2151	metal-sulfur cluster biosynthetic enzyme
NEB5A_RS07100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEB5A_RS07105	COG1024	Enoyl-CoA hydratase
NEB5A_RS07110	COG1024	Enoyl-CoA hydratase
NEB5A_RS07115	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEB5A_RS07120	COG2050	protein possibly involved in aromatic compounds catabolism
NEB5A_RS07125	COG0183	Belongs to the thiolase family
NEB5A_RS07130	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NEB5A_RS07135	COG3327	negative regulation of DNA-templated transcription, initiation
NEB5A_RS07140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NEB5A_RS07160	COG2826	transposase and inactivated derivatives, IS30 family
NEB5A_RS07170	COG0667	Aldo Keto reductase
NEB5A_RS07180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NEB5A_RS07185	COG4589	Belongs to the CDS family
NEB5A_RS07190	COG2267	carboxylic ester hydrolase activity
NEB5A_RS07195	COG0671	phosphoesterase, PA-phosphatase related
NEB5A_RS07195	COG2453	phosphatase
NEB5A_RS07205	COG1643	Atp-dependent helicase
NEB5A_RS07210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NEB5A_RS07215	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS07220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEB5A_RS07225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEB5A_RS07230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEB5A_RS07235	COG3038	cytochrome b561
NEB5A_RS07250	COG0840	transmembrane signaling receptor activity
NEB5A_RS07255	COG0583	DNA-binding transcription factor activity
NEB5A_RS07260	COG5383	Protein conserved in bacteria
NEB5A_RS07275	COG2841	Protein conserved in bacteria
NEB5A_RS07280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEB5A_RS07285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NEB5A_RS07290	COG1275	C4-dicarboxylate transporter malic acid transport protein
NEB5A_RS07295	COG0500	methyltransferase
NEB5A_RS07315	COG0675	Transposase, IS605 OrfB family
NEB5A_RS07320	COG3135	benzoate transporter
NEB5A_RS07325	COG1396	sequence-specific DNA binding
NEB5A_RS07330	COG0826	peptidase U32
NEB5A_RS07340	COG1724	mRNA binding
NEB5A_RS07345	COG1598	PFAM Uncharacterised protein family UPF0150
NEB5A_RS07350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEB5A_RS07355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NEB5A_RS07360	COG3842	ATPase activity
NEB5A_RS07365	COG1176	ABC-type spermidine putrescine transport system, permease component I
NEB5A_RS07370	COG1177	transmembrane transport
NEB5A_RS07395	COG3238	Protein conserved in bacteria
NEB5A_RS07400	COG1247	-acetyltransferase
NEB5A_RS07405	COG2130	NADP-dependent
NEB5A_RS07410	COG1802	Transcriptional regulator
NEB5A_RS07415	COG4772	TonB-dependent receptor
NEB5A_RS07420	COG3391	amine dehydrogenase activity
NEB5A_RS07425	COG1113	amino acid transport
NEB5A_RS07430	COG0625	glutathione transferase activity
NEB5A_RS07440	COG3209	COG3209 Rhs family protein
NEB5A_RS07450	COG5433	transposase activity
NEB5A_RS07455	COG5433	transposase activity
NEB5A_RS07465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NEB5A_RS07470	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NEB5A_RS07475	COG0384	phenazine biosynthesis protein PhzF
NEB5A_RS07480	COG2181	nitrate reductase activity
NEB5A_RS07485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NEB5A_RS07490	COG1140	nitrate reductase beta subunit
NEB5A_RS07495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NEB5A_RS07500	COG2223	nitrite transmembrane transporter activity
NEB5A_RS07510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NEB5A_RS07515	COG0697	spore germination
NEB5A_RS07520	COG0243	molybdopterin cofactor binding
NEB5A_RS07520	COG3383	formate dehydrogenase (NAD+) activity
NEB5A_RS07525	COG3383	formate dehydrogenase (NAD+) activity
NEB5A_RS07525	COG0243	molybdopterin cofactor binding
NEB5A_RS07530	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS07535	COG2864	formate dehydrogenase
NEB5A_RS07540	COG3093	addiction module antidote protein HigA
NEB5A_RS07545	COG1064	alcohol dehydrogenase
NEB5A_RS07565	COG1764	response to oxidative stress
NEB5A_RS07570	COG4608	Belongs to the ABC transporter superfamily
NEB5A_RS07575	COG0444	Belongs to the ABC transporter superfamily
NEB5A_RS07580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEB5A_RS07585	COG0601	transmembrane transport
NEB5A_RS07590	COG0747	negative chemotaxis
NEB5A_RS07595	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NEB5A_RS07600	COG2199	diguanylate cyclase activity
NEB5A_RS07600	COG2200	EAL domain
NEB5A_RS07600	COG2202	Pas domain
NEB5A_RS07605	COG3706	GGDEF domain
NEB5A_RS07610	COG1649	PFAM Uncharacterised BCR, COG1649
NEB5A_RS07615	COG0531	amino acid
NEB5A_RS07620	COG0076	glutamate decarboxylase activity
NEB5A_RS07630	COG0612	Peptidase, M16
NEB5A_RS07635	COG4771	TonB-dependent receptor
NEB5A_RS07640	COG4178	(ABC) transporter
NEB5A_RS07645	COG0641	radical SAM
NEB5A_RS07650	COG3119	arylsulfatase activity
NEB5A_RS07655	COG2207	Transcriptional regulator
NEB5A_RS07665	COG0243	molybdopterin cofactor binding
NEB5A_RS07670	COG3539	Fimbrial protein
NEB5A_RS07675	COG3539	Fimbrial protein
NEB5A_RS07680	COG3539	Fimbrial protein
NEB5A_RS07685	COG3188	usher protein
NEB5A_RS07690	COG4977	sequence-specific DNA binding
NEB5A_RS07695	COG3550	peptidyl-serine autophosphorylation
NEB5A_RS07700	COG1396	sequence-specific DNA binding
NEB5A_RS07710	COG3210	domain, Protein
NEB5A_RS07710	COG2911	Protein conserved in bacteria
NEB5A_RS07760	COG3781	membrane
NEB5A_RS07775	COG2199	diguanylate cyclase activity
NEB5A_RS07785	COG2066	Belongs to the glutaminase family
NEB5A_RS07790	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS07795	COG0583	DNA-binding transcription factor activity
NEB5A_RS07815	COG1846	Transcriptional regulator
NEB5A_RS07820	COG4977	sequence-specific DNA binding
NEB5A_RS07830	COG0697	spore germination
NEB5A_RS07835	COG2814	Major facilitator Superfamily
NEB5A_RS07845	COG3706	GGDEF domain
NEB5A_RS07850	COG3111	PFAM Bacterial OB fold (BOF) protein
NEB5A_RS07855	COG1546	Belongs to the CinA family
NEB5A_RS07860	COG0339	signal peptide processing
NEB5A_RS07865	COG4221	oxidoreductase activity
NEB5A_RS07870	COG1802	Transcriptional regulator
NEB5A_RS07880	COG0246	Mannitol dehydrogenase
NEB5A_RS07885	COG0477	Major facilitator Superfamily
NEB5A_RS07895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NEB5A_RS07900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NEB5A_RS07905	COG5301	cellulose 1,4-beta-cellobiosidase activity
NEB5A_RS07910	COG4220	transposase activity
NEB5A_RS07920	COG5562	phage envelope protein
NEB5A_RS07935	COG1278	Cold shock
NEB5A_RS07945	COG3772	lysozyme
NEB5A_RS07960	COG1278	Cold shock
NEB5A_RS07965	COG1278	Cold shock
NEB5A_RS07970	COG0484	heat shock protein binding
NEB5A_RS07975	COG1403	HNH endonuclease
NEB5A_RS07995	COG2026	Addiction module toxin, RelE StbE family
NEB5A_RS08000	COG3077	Addiction module antitoxin, RelB DinJ family
NEB5A_RS08025	COG1396	sequence-specific DNA binding
NEB5A_RS08065	COG0582	viral genome integration into host DNA
NEB5A_RS08070	COG1063	alcohol dehydrogenase
NEB5A_RS08075	COG4948	Mandelate Racemase Muconate Lactonizing
NEB5A_RS08090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEB5A_RS08105	COG0243	molybdopterin cofactor binding
NEB5A_RS08110	COG0243	molybdopterin cofactor binding
NEB5A_RS08115	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS08120	COG3302	dmso reductase anchor subunit
NEB5A_RS08125	COG3381	protein complex oligomerization
NEB5A_RS08135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NEB5A_RS08140	COG1940	carbohydrate kinase activity
NEB5A_RS08145	COG0583	DNA-binding transcription factor activity
NEB5A_RS08150	COG2814	Major facilitator Superfamily
NEB5A_RS08165	COG3591	Belongs to the peptidase S1B family
NEB5A_RS08180	COG0628	permease
NEB5A_RS08185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NEB5A_RS08190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NEB5A_RS08200	COG0531	amino acid
NEB5A_RS08210	COG3136	membrane protein required for alginate biosynthesis
NEB5A_RS08215	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS08220	COG2205	protein histidine kinase activity
NEB5A_RS08230	COG0114	fumarate hydratase activity
NEB5A_RS08235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NEB5A_RS08235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NEB5A_RS08240	COG1482	cell wall glycoprotein biosynthetic process
NEB5A_RS08245	COG5339	Protein conserved in bacteria
NEB5A_RS08255	COG2211	Major facilitator Superfamily
NEB5A_RS08260	COG3250	beta-galactosidase activity
NEB5A_RS08265	COG1309	transcriptional regulator
NEB5A_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS08275	COG1609	Transcriptional regulator
NEB5A_RS08280	COG1263	PTS System
NEB5A_RS08280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS08285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NEB5A_RS08295	COG0673	inositol 2-dehydrogenase activity
NEB5A_RS08335	COG4659	FMN binding
NEB5A_RS08345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NEB5A_RS08355	COG3104	oligopeptide transport
NEB5A_RS08360	COG0625	glutathione transferase activity
NEB5A_RS08365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NEB5A_RS08380	COG3895	Periplasmic Protein
NEB5A_RS08390	COG3133	Outer membrane lipoprotein
NEB5A_RS08405	COG1566	PFAM secretion protein HlyD family protein
NEB5A_RS08410	COG1289	transmembrane transporter activity
NEB5A_RS08415	COG2032	superoxide dismutase activity
NEB5A_RS08420	COG4989	oxidoreductase activity
NEB5A_RS08425	COG3313	Fe-S protein
NEB5A_RS08430	COG1309	transcriptional regulator
NEB5A_RS08435	COG1902	pentaerythritol trinitrate reductase activity
NEB5A_RS08440	COG0346	lactoylglutathione lyase activity
NEB5A_RS08445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEB5A_RS08450	COG1201	RNA secondary structure unwinding
NEB5A_RS08455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NEB5A_RS08460	COG0791	NLP P60 protein
NEB5A_RS08465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NEB5A_RS08470	COG2814	Major facilitator Superfamily
NEB5A_RS08485	COG0583	DNA-binding transcription factor activity
NEB5A_RS08490	COG2814	Major facilitator Superfamily
NEB5A_RS08495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NEB5A_RS08500	COG0307	riboflavin synthase, alpha
NEB5A_RS08510	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS08530	COG4529	Protein conserved in bacteria
NEB5A_RS08540	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
NEB5A_RS08545	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS08555	COG2414	aldehyde ferredoxin oxidoreductase
NEB5A_RS08560	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS08570	COG0469	pyruvate kinase activity
NEB5A_RS08575	COG4238	major outer membrane lipoprotein
NEB5A_RS08580	COG1376	ErfK ybiS ycfS ynhG family protein
NEB5A_RS08595	COG0719	Fe-S assembly protein
NEB5A_RS08600	COG0396	ATPase activity
NEB5A_RS08605	COG0719	Fe-S assembly protein
NEB5A_RS08610	COG0316	Belongs to the HesB IscA family
NEB5A_RS08620	COG2050	protein possibly involved in aromatic compounds catabolism
NEB5A_RS08625	COG0247	lactate metabolic process
NEB5A_RS08625	COG0277	FAD linked oxidase domain protein
NEB5A_RS08630	COG0628	permease
NEB5A_RS08645	COG0738	Major facilitator superfamily
NEB5A_RS08650	COG2271	Major facilitator Superfamily
NEB5A_RS08665	COG4670	ketone body catabolic process
NEB5A_RS08670	COG1960	acyl-CoA dehydrogenase activity
NEB5A_RS08675	COG1917	Cupin 2, conserved barrel domain protein
NEB5A_RS08675	COG2207	Transcriptional regulator
NEB5A_RS08685	COG2086	electron transfer activity
NEB5A_RS08690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NEB5A_RS08695	COG0644	oxidoreductase
NEB5A_RS08700	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NEB5A_RS08705	COG0318	PFAM AMP-dependent synthetase and ligase
NEB5A_RS08710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEB5A_RS08710	COG0574	Belongs to the PEP-utilizing enzyme family
NEB5A_RS08725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NEB5A_RS08730	COG4256	Hemin uptake protein
NEB5A_RS08740	COG2200	EAL domain
NEB5A_RS08745	COG0791	NLP P60 protein
NEB5A_RS08755	COG0386	Belongs to the glutathione peroxidase family
NEB5A_RS08770	COG0072	phenylalanine-tRNA ligase activity
NEB5A_RS08770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEB5A_RS08815	COG3137	Salt-induced outer membrane protein
NEB5A_RS08820	COG1105	Belongs to the carbohydrate kinase PfkB family
NEB5A_RS08830	COG3001	Fructosamine kinase
NEB5A_RS08840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEB5A_RS08845	COG1988	membrane-bound metal-dependent
NEB5A_RS08850	COG1823	symporter activity
NEB5A_RS08865	COG0753	catalase activity
NEB5A_RS08875	COG1486	melibiose metabolic process
NEB5A_RS08880	COG1917	Cupin 2, conserved barrel domain protein
NEB5A_RS08880	COG2169	Transcriptional regulator
NEB5A_RS08885	COG1447	Phosphotransferase system cellobiose-specific component IIA
NEB5A_RS08890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NEB5A_RS08895	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NEB5A_RS08900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEB5A_RS08915	COG0322	excinuclease ABC activity
NEB5A_RS08925	COG3678	ATP-independent chaperone mediated protein folding
NEB5A_RS08955	COG0708	Exodeoxyribonuclease III
NEB5A_RS08960	COG0398	Pfam SNARE associated Golgi protein
NEB5A_RS08970	COG0398	Pfam SNARE associated Golgi protein
NEB5A_RS08975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEB5A_RS08980	COG4134	Bacterial extracellular solute-binding protein
NEB5A_RS08985	COG4135	transport system, permease component
NEB5A_RS08990	COG4136	ATPase activity
NEB5A_RS08995	COG2897	thiosulfate sulfurtransferase activity
NEB5A_RS09000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NEB5A_RS09005	COG0494	nUDIX hydrolase
NEB5A_RS09015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NEB5A_RS09025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NEB5A_RS09040	COG0778	Nitroreductase
NEB5A_RS09050	COG0616	signal peptide processing
NEB5A_RS09055	COG0252	asparaginase activity
NEB5A_RS09060	COG1335	isochorismatase
NEB5A_RS09065	COG2814	Major facilitator Superfamily
NEB5A_RS09070	COG1349	DNA-binding transcription factor activity
NEB5A_RS09075	COG0667	Aldo Keto reductase
NEB5A_RS09080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS09085	COG0191	fructose-bisphosphate aldolase activity
NEB5A_RS09090	COG1063	alcohol dehydrogenase
NEB5A_RS09095	COG2271	Major facilitator Superfamily
NEB5A_RS09100	COG1063	alcohol dehydrogenase
NEB5A_RS09105	COG3139	Protein of unknown function (DUF1315)
NEB5A_RS09115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEB5A_RS09120	COG0676	glucose-6-phosphate 1-epimerase activity
NEB5A_RS09125	COG0656	L-ascorbic acid biosynthetic process
NEB5A_RS09130	COG3713	MltA-interacting MipA family protein
NEB5A_RS09135	COG2766	serine protein kinase
NEB5A_RS09145	COG2199	diguanylate cyclase activity
NEB5A_RS09150	COG2199	diguanylate cyclase activity
NEB5A_RS09155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NEB5A_RS09170	COG2207	Transcriptional regulator
NEB5A_RS09175	COG2807	transmembrane transport
NEB5A_RS09180	COG3189	MarR family transcriptional regulator
NEB5A_RS09185	COG3042	response to heat
NEB5A_RS09190	COG2199	diguanylate cyclase activity
NEB5A_RS09190	COG2203	Gaf domain
NEB5A_RS09200	COG2261	transglycosylase associated protein
NEB5A_RS09210	COG3615	Tellurite resistance protein tehB
NEB5A_RS09220	COG0583	DNA-binding transcription factor activity
NEB5A_RS09225	COG0473	3-isopropylmalate dehydrogenase activity
NEB5A_RS09230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NEB5A_RS09235	COG4638	Rieske (2fe-2S)
NEB5A_RS09240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEB5A_RS09245	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NEB5A_RS09250	COG0318	PFAM AMP-dependent synthetase and ligase
NEB5A_RS09255	COG3065	identical protein binding
NEB5A_RS09260	COG1214	PFAM Peptidase M22, glycoprotease
NEB5A_RS09265	COG1199	ATP-dependent helicase activity
NEB5A_RS09270	COG0251	oxidation-reduction process
NEB5A_RS09285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NEB5A_RS09295	COG1760	l-serine dehydratase
NEB5A_RS09300	COG2200	EAL domain
NEB5A_RS09305	COG1253	flavin adenine dinucleotide binding
NEB5A_RS09315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS09315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS09320	COG3715	PTS system
NEB5A_RS09325	COG3716	PTS system mannose fructose sorbose family IID component
NEB5A_RS09345	COG2226	methyltransferase
NEB5A_RS09380	COG1414	Transcriptional regulator
NEB5A_RS09390	COG1414	Transcriptional regulator
NEB5A_RS09395	COG2814	Major facilitator Superfamily
NEB5A_RS09405	COG0793	Belongs to the peptidase S41A family
NEB5A_RS09415	COG1956	GAF domain-containing protein
NEB5A_RS09420	COG2995	paraquat-inducible protein a
NEB5A_RS09425	COG3008	intermembrane lipid transfer
NEB5A_RS09445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NEB5A_RS09460	COG1276	copper resistance
NEB5A_RS09465	COG2372	response to copper ion
NEB5A_RS09475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NEB5A_RS09480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEB5A_RS09485	COG1770	oligopeptidase
NEB5A_RS09490	COG2979	Protein of unknown function (DUF533)
NEB5A_RS09505	COG3141	response to X-ray
NEB5A_RS09515	COG0800	Aldolase
NEB5A_RS09520	COG0129	dihydroxy-acid dehydratase activity
NEB5A_RS09525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NEB5A_RS09535	COG1737	Transcriptional regulator
NEB5A_RS09540	COG0469	pyruvate kinase activity
NEB5A_RS09545	COG1560	Kdo2-lipid A biosynthetic process
NEB5A_RS09550	COG0739	heme binding
NEB5A_RS09555	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NEB5A_RS09565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NEB5A_RS09590	COG0217	transcriptional regulatory protein
NEB5A_RS09595	COG0494	nUDIX hydrolase
NEB5A_RS09605	COG1335	isochorismatase
NEB5A_RS09610	COG1801	Protein of unknown function DUF72
NEB5A_RS09615	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NEB5A_RS09630	COG0243	molybdopterin cofactor binding
NEB5A_RS09635	COG3005	denitrification pathway
NEB5A_RS09645	COG3102	Protein conserved in bacteria
NEB5A_RS09655	COG3755	Protein conserved in bacteria
NEB5A_RS09665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NEB5A_RS09670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NEB5A_RS09675	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NEB5A_RS09680	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS09685	COG2201	protein-glutamate methylesterase activity
NEB5A_RS09690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NEB5A_RS09695	COG0840	transmembrane signaling receptor activity
NEB5A_RS09700	COG0840	transmembrane signaling receptor activity
NEB5A_RS09705	COG0835	chemotaxis
NEB5A_RS09710	COG0643	Histidine kinase
NEB5A_RS09710	COG2198	Histidine kinase
NEB5A_RS09715	COG1360	Flagellar Motor Protein
NEB5A_RS09720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NEB5A_RS09735	COG0589	response to stress
NEB5A_RS09745	COG1877	trehalose-phosphatase activity
NEB5A_RS09750	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS09755	COG1129	ABC transporter
NEB5A_RS09760	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS09765	COG1528	Iron-storage protein
NEB5A_RS09785	COG1528	Iron-storage protein
NEB5A_RS09795	COG0814	amino acid
NEB5A_RS09800	COG3318	Belongs to the UPF0149 family
NEB5A_RS09800	COG3012	SEC-C Motif Domain Protein
NEB5A_RS09830	COG2197	response regulator
NEB5A_RS09845	COG2197	response regulator
NEB5A_RS09850	COG1126	abc transporter atp-binding protein
NEB5A_RS09855	COG0765	amino acid transport
NEB5A_RS09865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS09875	COG1191	sigma factor activity
NEB5A_RS09880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NEB5A_RS09885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NEB5A_RS09890	COG1516	flagellar protein fliS
NEB5A_RS09900	COG0366	Alpha amylase catalytic
NEB5A_RS09910	COG2391	methyltransferase activity
NEB5A_RS09915	COG0425	Belongs to the sulfur carrier protein TusA family
NEB5A_RS09920	COG2135	peptidase activity
NEB5A_RS09925	COG0454	-acetyltransferase
NEB5A_RS09950	COG1766	The M ring may be actively involved in energy transduction
NEB5A_RS09955	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NEB5A_RS09960	COG1317	bacterial-type flagellum organization
NEB5A_RS09965	COG1157	protein secretion by the type III secretion system
NEB5A_RS09970	COG2882	bacterial-type flagellum organization
NEB5A_RS09975	COG3144	bacterial-type flagellum assembly
NEB5A_RS09980	COG1580	Controls the rotational direction of flagella during chemotaxis
NEB5A_RS09985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NEB5A_RS09990	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NEB5A_RS09995	COG3190	flagellar
NEB5A_RS10000	COG1338	Plays a role in the flagellum-specific transport system
NEB5A_RS10005	COG1987	bacterial-type flagellum assembly
NEB5A_RS10010	COG1684	flagellar biosynthetic protein fliR
NEB5A_RS10015	COG2197	response regulator
NEB5A_RS10035	COG3706	GGDEF domain
NEB5A_RS10040	COG5475	Uncharacterized small protein (DUF2158)
NEB5A_RS10045	COG2354	Protein conserved in bacteria
NEB5A_RS10050	COG0697	spore germination
NEB5A_RS10055	COG3727	T/G mismatch-specific endonuclease activity
NEB5A_RS10060	COG0270	DNA (cytosine-5-)-methyltransferase activity
NEB5A_RS10065	COG1418	mRNA catabolic process
NEB5A_RS10090	COG2205	protein histidine kinase activity
NEB5A_RS10095	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS10100	COG2351	hydroxyisourate hydrolase activity
NEB5A_RS10115	COG3443	Belongs to the bacterial solute-binding protein 9 family
NEB5A_RS10120	COG3038	cytochrome b561
NEB5A_RS10145	COG1470	cell adhesion involved in biofilm formation
NEB5A_RS10145	COG1388	LysM domain
NEB5A_RS10155	COG0477	Major facilitator Superfamily
NEB5A_RS10160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NEB5A_RS10165	COG0217	transcriptional regulatory protein
NEB5A_RS10175	COG0534	Mate efflux family protein
NEB5A_RS10185	COG0583	DNA-binding transcription factor activity
NEB5A_RS10190	COG0583	DNA-binding transcription factor activity
NEB5A_RS10200	COG1376	ErfK ybiS ycfS ynhG family protein
NEB5A_RS10215	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
NEB5A_RS10220	COG3039	Transposase
NEB5A_RS10240	COG4771	TonB-dependent receptor
NEB5A_RS10250	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS10260	COG2003	Belongs to the UPF0758 family
NEB5A_RS10300	COG1289	transmembrane transporter activity
NEB5A_RS10310	COG1686	Belongs to the peptidase S11 family
NEB5A_RS10315	COG2925	Exonuclease
NEB5A_RS10320	COG0425	Belongs to the sulfur carrier protein TusA family
NEB5A_RS10325	COG2391	methyltransferase activity
NEB5A_RS10330	COG0531	amino acid
NEB5A_RS10335	COG0583	DNA-binding transcription factor activity
NEB5A_RS10340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEB5A_RS10345	COG4115	mRNA cleavage
NEB5A_RS10350	COG2161	toxin-antitoxin pair type II binding
NEB5A_RS10360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NEB5A_RS10370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NEB5A_RS10370	COG0131	Imidazoleglycerol-phosphate dehydratase
NEB5A_RS10375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NEB5A_RS10390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NEB5A_RS10390	COG0140	phosphoribosyl-ATP diphosphatase activity
NEB5A_RS10395	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
NEB5A_RS10400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NEB5A_RS10405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NEB5A_RS10420	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS10425	COG0110	maltose O-acetyltransferase activity
NEB5A_RS10430	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS10440	COG0562	UDP-galactopyranose mutase
NEB5A_RS10445	COG2244	polysaccharide biosynthetic process
NEB5A_RS10450	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NEB5A_RS10455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NEB5A_RS10465	COG1088	dTDP-glucose 4,6-dehydratase activity
NEB5A_RS10470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NEB5A_RS10480	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS10485	COG2327	Polysaccharide pyruvyl transferase
NEB5A_RS10490	COG2244	polysaccharide biosynthetic process
NEB5A_RS10495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NEB5A_RS10500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NEB5A_RS10505	COG0662	Cupin 2, conserved barrel domain protein
NEB5A_RS10505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NEB5A_RS10510	COG0297	glycogen (starch) synthase activity
NEB5A_RS10515	COG1051	belongs to the nudix hydrolase family
NEB5A_RS10520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NEB5A_RS10525	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NEB5A_RS10530	COG0110	maltose O-acetyltransferase activity
NEB5A_RS10535	COG1216	Glycosyl transferase, family 2
NEB5A_RS10545	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS10550	COG1045	serine acetyltransferase
NEB5A_RS10555	COG0463	Glycosyl transferase, family 2
NEB5A_RS10560	COG3206	protein involved in exopolysaccharide biosynthesis
NEB5A_RS10560	COG0489	protein tyrosine kinase activity
NEB5A_RS10565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NEB5A_RS10570	COG1596	polysaccharide export
NEB5A_RS10575	COG1253	flavin adenine dinucleotide binding
NEB5A_RS10580	COG2982	Protein involved in outer membrane biogenesis
NEB5A_RS10590	COG0572	uridine kinase
NEB5A_RS10595	COG5001	Diguanylate cyclase
NEB5A_RS10595	COG3447	MASE1 domain protein
NEB5A_RS10595	COG5002	protein histidine kinase activity
NEB5A_RS10600	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NEB5A_RS10610	COG0443	Heat shock 70 kDa protein
NEB5A_RS10615	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
NEB5A_RS10620	COG3779	Protein conserved in bacteria
NEB5A_RS10625	COG0631	protein serine/threonine phosphatase activity
NEB5A_RS10630	COG4245	von Willebrand factor, type A
NEB5A_RS10655	COG2205	protein histidine kinase activity
NEB5A_RS10660	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS10665	COG3422	double-strand break repair
NEB5A_RS10670	COG0826	peptidase U32
NEB5A_RS10700	COG2801	Transposase and inactivated derivatives
NEB5A_RS10710	COG1063	alcohol dehydrogenase
NEB5A_RS10715	COG3775	system Galactitol-specific IIC component
NEB5A_RS10725	COG3414	Phosphotransferase system galactitol-specific IIB component
NEB5A_RS10730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS10745	COG1830	Aldolase
NEB5A_RS10750	COG2211	Major facilitator Superfamily
NEB5A_RS10755	COG1397	ADP-ribosylglycohydrolase
NEB5A_RS10760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS10765	COG2188	Transcriptional regulator
NEB5A_RS10770	COG3757	hydrolase, family 25
NEB5A_RS10775	COG0351	phosphomethylpyrimidine kinase
NEB5A_RS10790	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
NEB5A_RS10795	COG5455	response to cobalt ion
NEB5A_RS10800	COG3539	Fimbrial protein
NEB5A_RS10805	COG3188	usher protein
NEB5A_RS10810	COG3121	Chaperone
NEB5A_RS10815	COG3539	Fimbrial protein
NEB5A_RS10830	COG0489	protein tyrosine kinase activity
NEB5A_RS10850	COG3831	ATPase activity
NEB5A_RS10860	COG0714	Associated with various cellular activities
NEB5A_RS10865	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NEB5A_RS10870	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NEB5A_RS10875	COG4715	Zinc finger, swim domain protein
NEB5A_RS10880	COG4808	Protein conserved in bacteria
NEB5A_RS10885	COG4807	Protein conserved in bacteria
NEB5A_RS10890	COG3279	Response regulator of the LytR AlgR family
NEB5A_RS10895	COG3275	phosphorelay sensor kinase activity
NEB5A_RS10900	COG0789	Transcriptional regulator
NEB5A_RS10910	COG1174	glycine betaine transport
NEB5A_RS10915	COG1125	glycine betaine transport
NEB5A_RS10920	COG1174	glycine betaine transport
NEB5A_RS10925	COG1732	Glycine betaine
NEB5A_RS10930	COG1472	Belongs to the glycosyl hydrolase 3 family
NEB5A_RS10935	COG0277	FAD linked oxidase domain protein
NEB5A_RS10940	COG1686	Belongs to the peptidase S11 family
NEB5A_RS10950	COG0586	Pfam SNARE associated Golgi protein
NEB5A_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS10970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NEB5A_RS10980	COG1346	cytolysis
NEB5A_RS10990	COG2949	membrane
NEB5A_RS11000	COG0493	'glutamate synthase
NEB5A_RS11005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NEB5A_RS11005	COG0167	dihydroorotate dehydrogenase activity
NEB5A_RS11010	COG4211	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS11015	COG1129	ABC transporter
NEB5A_RS11020	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS11025	COG1609	Transcriptional regulator
NEB5A_RS11035	COG2311	Membrane
NEB5A_RS11055	COG4771	TonB-dependent receptor
NEB5A_RS11060	COG0833	amino acid
NEB5A_RS11065	COG0583	DNA-binding transcription factor activity
NEB5A_RS11070	COG2855	membrane
NEB5A_RS11080	COG1522	sequence-specific DNA binding
NEB5A_RS11080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS11085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NEB5A_RS11095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEB5A_RS11100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NEB5A_RS11105	COG2313	pseudouridylate synthase activity
NEB5A_RS11110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS11115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NEB5A_RS11115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS11115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS11120	COG1105	Belongs to the carbohydrate kinase PfkB family
NEB5A_RS11125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS11125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS11130	COG2814	Major facilitator Superfamily
NEB5A_RS11145	COG0246	Mannitol dehydrogenase
NEB5A_RS11150	COG0523	cobalamin synthesis protein
NEB5A_RS11155	COG0671	phosphoesterase, PA-phosphatase related
NEB5A_RS11160	COG0791	NLP P60 protein
NEB5A_RS11165	COG2200	EAL domain
NEB5A_RS11170	COG4166	transmembrane transport
NEB5A_RS11175	COG4174	ABC transporter (Permease)
NEB5A_RS11180	COG4239	(ABC) transporter, permease
NEB5A_RS11185	COG4172	Belongs to the ABC transporter superfamily
NEB5A_RS11195	COG2814	Major facilitator Superfamily
NEB5A_RS11200	COG1187	pseudouridine synthase activity
NEB5A_RS11205	COG1061	Type III restriction enzyme res subunit
NEB5A_RS11225	COG3083	sulfuric ester hydrolase activity
NEB5A_RS11235	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS11250	COG2197	response regulator
NEB5A_RS11255	COG3088	subunit of a heme lyase
NEB5A_RS11255	COG4235	cytochrome complex assembly
NEB5A_RS11260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NEB5A_RS11265	COG1138	Cytochrome C-type biogenesis protein
NEB5A_RS11275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NEB5A_RS11280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NEB5A_RS11285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NEB5A_RS11290	COG4133	protoheme IX ABC transporter activity
NEB5A_RS11295	COG3005	denitrification pathway
NEB5A_RS11300	COG3043	anaerobic respiration
NEB5A_RS11305	COG0348	domain, Protein
NEB5A_RS11310	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS11320	COG3062	negative regulation of establishment of protein localization
NEB5A_RS11325	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS11325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS11345	COG4615	Cyclic peptide transporter
NEB5A_RS11350	COG3145	DNA-N1-methyladenine dioxygenase activity
NEB5A_RS11355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NEB5A_RS11355	COG2169	Transcriptional regulator
NEB5A_RS11360	COG1477	protein flavinylation
NEB5A_RS11365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NEB5A_RS11380	COG2198	Histidine kinase
NEB5A_RS11380	COG0642	Histidine kinase
NEB5A_RS11385	COG2197	response regulator
NEB5A_RS11390	COG2205	protein histidine kinase activity
NEB5A_RS11390	COG0784	Response regulator, receiver
NEB5A_RS11395	COG3852	Histidine kinase
NEB5A_RS11400	COG2204	response regulator
NEB5A_RS11405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NEB5A_RS11410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NEB5A_RS11415	COG2031	fatty acid transporter
NEB5A_RS11420	COG0183	Belongs to the thiolase family
NEB5A_RS11425	COG4676	Protein conserved in bacteria
NEB5A_RS11430	COG5445	Predicted secreted protein (DUF2300)
NEB5A_RS11435	COG2373	Large extracellular alpha-helical protein
NEB5A_RS11445	COG3234	Protein of unknown function (DUF1175)
NEB5A_RS11450	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
NEB5A_RS11455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NEB5A_RS11465	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS11475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEB5A_RS11480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEB5A_RS11485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEB5A_RS11490	COG3642	lipopolysaccharide core region biosynthetic process
NEB5A_RS11495	COG0583	DNA-binding transcription factor activity
NEB5A_RS11500	COG0584	glycerophosphoryl diester phosphodiesterase
NEB5A_RS11505	COG2271	Major facilitator Superfamily
NEB5A_RS11510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NEB5A_RS11520	COG0247	lactate metabolic process
NEB5A_RS11525	COG5464	transposase or invertase
NEB5A_RS11540	COG2271	Major facilitator Superfamily
NEB5A_RS11550	COG1414	Transcriptional regulator
NEB5A_RS11615	COG0318	PFAM AMP-dependent synthetase and ligase
NEB5A_RS11625	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NEB5A_RS11640	COG1169	isochorismate synthase
NEB5A_RS11645	COG4575	ribosome binding
NEB5A_RS11650	COG2153	protein acetylation
NEB5A_RS11660	COG5160	protein modification by small protein removal
NEB5A_RS11665	COG2304	oxidoreductase activity
NEB5A_RS11670	COG2234	aminopeptidase activity
NEB5A_RS11690	COG0457	Tetratricopeptide repeat
NEB5A_RS11700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEB5A_RS11705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NEB5A_RS11715	COG0839	Belongs to the complex I subunit 6 family
NEB5A_RS11730	COG1034	ATP synthesis coupled electron transport
NEB5A_RS11735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NEB5A_RS11740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NEB5A_RS11760	COG0583	DNA-binding transcription factor activity
NEB5A_RS11765	COG0436	Aminotransferase
NEB5A_RS11775	COG0490	domain, Protein
NEB5A_RS11775	COG0471	metal ion transport
NEB5A_RS11780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEB5A_RS11800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NEB5A_RS11805	COG0280	phosphate acetyltransferase
NEB5A_RS11805	COG0857	belongs to the CobB CobQ family
NEB5A_RS11810	COG1288	antiporter activity
NEB5A_RS11815	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NEB5A_RS11820	COG0622	Phosphoesterase
NEB5A_RS11825	COG0625	glutathione transferase activity
NEB5A_RS11830	COG0625	glutathione transferase activity
NEB5A_RS11835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NEB5A_RS11840	COG1090	epimerase
NEB5A_RS11845	COG5464	transposase or invertase
NEB5A_RS11850	COG4598	ABC transporter
NEB5A_RS11855	COG4160	amino acid transport
NEB5A_RS11860	COG4215	(ABC) transporter
NEB5A_RS11865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS11875	COG0163	prenyltransferase activity
NEB5A_RS11880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NEB5A_RS11885	COG1286	toxin biosynthetic process
NEB5A_RS11890	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
NEB5A_RS11895	COG0285	dihydrofolate synthase activity
NEB5A_RS11905	COG0586	Pfam SNARE associated Golgi protein
NEB5A_RS11915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NEB5A_RS11930	COG2814	Major facilitator Superfamily
NEB5A_RS11935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEB5A_RS11950	COG3101	peptidyl-lysine hydroxylation
NEB5A_RS11955	COG0730	response to heat
NEB5A_RS11970	COG2890	protein-(glutamine-N5) methyltransferase activity
NEB5A_RS11985	COG3539	Fimbrial protein
NEB5A_RS11990	COG3539	Fimbrial protein
NEB5A_RS11995	COG3539	Fimbrial protein
NEB5A_RS12000	COG3121	Chaperone
NEB5A_RS12010	COG3539	Fimbrial protein
NEB5A_RS12015	COG2062	phosphohistidine phosphatase, SixA
NEB5A_RS12030	COG3691	Protein conserved in bacteria
NEB5A_RS12035	COG2067	long-chain fatty acid transport protein
NEB5A_RS12045	COG2853	Lipoprotein
NEB5A_RS12050	COG2116	formate transmembrane transporter activity
NEB5A_RS12060	COG0582	viral genome integration into host DNA
NEB5A_RS12065	COG2246	polysaccharide biosynthetic process
NEB5A_RS12070	COG0463	Glycosyl transferase, family 2
NEB5A_RS12095	COG4725	Belongs to the MT-A70-like family
NEB5A_RS12105	COG1846	Transcriptional regulator
NEB5A_RS12115	COG5532	Uncharacterized conserved protein (DUF2303)
NEB5A_RS12120	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NEB5A_RS12140	COG0583	DNA-binding transcription factor activity
NEB5A_RS12145	COG2610	gluconate transmembrane transporter activity
NEB5A_RS12155	COG0477	Major facilitator Superfamily
NEB5A_RS12160	COG1566	PFAM secretion protein HlyD family protein
NEB5A_RS12165	COG2197	response regulator
NEB5A_RS12170	COG0784	Response regulator, receiver
NEB5A_RS12170	COG2198	Histidine kinase
NEB5A_RS12170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS12170	COG2205	protein histidine kinase activity
NEB5A_RS12175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NEB5A_RS12180	COG0679	Auxin Efflux Carrier
NEB5A_RS12185	COG0028	Belongs to the TPP enzyme family
NEB5A_RS12215	COG1560	Kdo2-lipid A biosynthetic process
NEB5A_RS12220	COG0436	Aminotransferase
NEB5A_RS12225	COG3275	phosphorelay sensor kinase activity
NEB5A_RS12230	COG3279	Response regulator of the LytR AlgR family
NEB5A_RS12235	COG2207	Transcriptional regulator
NEB5A_RS12240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS12240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS12240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEB5A_RS12245	COG1363	Peptidase, m42
NEB5A_RS12250	COG0006	proline dipeptidase activity
NEB5A_RS12255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS12260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS12290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NEB5A_RS12295	COG3385	transposase activity
NEB5A_RS12300	COG2199	diguanylate cyclase activity
NEB5A_RS12300	COG2200	EAL domain
NEB5A_RS12315	COG3415	Transposase
NEB5A_RS12320	COG3415	Transposase
NEB5A_RS12355	COG0583	DNA-binding transcription factor activity
NEB5A_RS12365	COG2211	Major facilitator Superfamily
NEB5A_RS12370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NEB5A_RS12380	COG0583	DNA-binding transcription factor activity
NEB5A_RS12385	COG0385	Bile acid
NEB5A_RS12390	COG3530	Putative quorum-sensing-regulated virulence factor
NEB5A_RS12410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NEB5A_RS12415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS12420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEB5A_RS12425	COG2190	(PTS) system
NEB5A_RS12440	COG4884	unkown
NEB5A_RS12440	COG3831	ATPase activity
NEB5A_RS12445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NEB5A_RS12450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NEB5A_RS12455	COG4208	sulfate ABC transporter
NEB5A_RS12460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NEB5A_RS12465	COG4150	thiosulfate binding
NEB5A_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS12485	COG1263	PTS System
NEB5A_RS12485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS12490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEB5A_RS12495	COG2837	iron assimilation
NEB5A_RS12510	COG0456	acetyltransferase
NEB5A_RS12515	COG0860	N-Acetylmuramoyl-L-alanine amidase
NEB5A_RS12525	COG2207	Transcriptional regulator
NEB5A_RS12530	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NEB5A_RS12535	COG4816	utilization protein
NEB5A_RS12545	COG4303	Ethanolamine ammonia lyase large subunit
NEB5A_RS12550	COG4819	ethanolamine utilization protein
NEB5A_RS12555	COG3192	ethanolamine utilization protein
NEB5A_RS12560	COG1454	alcohol dehydrogenase
NEB5A_RS12565	COG4820	ethanolamine utilization protein (EutJ)
NEB5A_RS12570	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS12575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NEB5A_RS12580	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NEB5A_RS12585	COG0280	phosphate acetyltransferase
NEB5A_RS12590	COG4812	Cobalamin adenosyltransferase
NEB5A_RS12595	COG4766	ethanolamine catabolic process
NEB5A_RS12600	COG4917	ethanolamine utilization protein
NEB5A_RS12605	COG4810	utilization protein
NEB5A_RS12610	COG0280	phosphate acetyltransferase
NEB5A_RS12610	COG0281	malic enzyme
NEB5A_RS12615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NEB5A_RS12620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NEB5A_RS12625	COG5342	invasion associated locus B
NEB5A_RS12635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS12635	COG0493	'glutamate synthase
NEB5A_RS12640	COG3850	Histidine kinase
NEB5A_RS12645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEB5A_RS12655	COG1393	Belongs to the ArsC family
NEB5A_RS12670	COG0400	carboxylic ester hydrolase activity
NEB5A_RS12675	COG1444	tRNA N-acetyltransferase activity
NEB5A_RS12680	COG2321	neutral zinc metallopeptidase
NEB5A_RS12695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NEB5A_RS12705	COG2716	regulation of RNA biosynthetic process
NEB5A_RS12710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NEB5A_RS12715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS12720	COG0651	ATP synthesis coupled electron transport
NEB5A_RS12725	COG0650	Formate hydrogenlyase subunit 4
NEB5A_RS12730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NEB5A_RS12735	COG4237	Hydrogenase 4 membrane
NEB5A_RS12740	COG0651	ATP synthesis coupled electron transport
NEB5A_RS12745	COG3261	NADH dehydrogenase
NEB5A_RS12745	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NEB5A_RS12750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEB5A_RS12755	COG3260	NADH ubiquinone oxidoreductase 20
NEB5A_RS12765	COG3604	Transcriptional regulator
NEB5A_RS12770	COG2116	formate transmembrane transporter activity
NEB5A_RS12775	COG0628	permease
NEB5A_RS12780	COG4783	chaperone-mediated protein folding
NEB5A_RS12785	COG1393	Belongs to the ArsC family
NEB5A_RS12795	COG2233	PERMEase
NEB5A_RS12810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NEB5A_RS12815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NEB5A_RS12820	COG0248	Ppx GppA phosphatase
NEB5A_RS12825	COG2200	EAL domain
NEB5A_RS12840	COG3133	Outer membrane lipoprotein
NEB5A_RS12855	COG0517	IMP dehydrogenase activity
NEB5A_RS12855	COG0516	GMP reductase activity
NEB5A_RS12865	COG1645	bacterial-type flagellum-dependent swarming motility
NEB5A_RS12875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEB5A_RS12880	COG2976	Protein conserved in bacteria
NEB5A_RS12910	COG4953	penicillin-binding protein 1C
NEB5A_RS12915	COG2373	Large extracellular alpha-helical protein
NEB5A_RS12920	COG2897	thiosulfate sulfurtransferase activity
NEB5A_RS12935	COG2975	iron-sulfur cluster assembly
NEB5A_RS12940	COG0633	Ferredoxin
NEB5A_RS12960	COG0822	iron-sulfur transferase activity
NEB5A_RS12980	COG0483	inositol monophosphate 1-phosphatase activity
NEB5A_RS12985	COG1073	alpha beta
NEB5A_RS12990	COG3711	transcriptional antiterminator
NEB5A_RS12995	COG2814	Major facilitator Superfamily
NEB5A_RS13000	COG0583	DNA-binding transcription factor activity
NEB5A_RS13005	COG4638	Rieske (2fe-2S)
NEB5A_RS13030	COG2259	Doxx family
NEB5A_RS13035	COG2017	converts alpha-aldose to the beta-anomer
NEB5A_RS13040	COG1063	alcohol dehydrogenase
NEB5A_RS13045	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS13050	COG1129	ABC transporter
NEB5A_RS13055	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS13060	COG0457	Tetratricopeptide repeat
NEB5A_RS13065	COG1940	carbohydrate kinase activity
NEB5A_RS13075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEB5A_RS13075	COG1017	nitric oxide dioxygenase activity
NEB5A_RS13080	COG0347	Belongs to the P(II) protein family
NEB5A_RS13085	COG2204	response regulator
NEB5A_RS13090	COG3170	Tfp pilus assembly protein FimV
NEB5A_RS13095	COG2205	protein histidine kinase activity
NEB5A_RS13100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NEB5A_RS13100	COG0047	phosphoribosylformylglycinamidine synthase activity
NEB5A_RS13115	COG0560	Phosphoserine phosphatase
NEB5A_RS13120	COG1737	Transcriptional regulator
NEB5A_RS13125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS13150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NEB5A_RS13170	COG0681	Belongs to the peptidase S26 family
NEB5A_RS13180	COG3086	response to oxidative stress
NEB5A_RS13185	COG3026	antisigma factor binding
NEB5A_RS13190	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NEB5A_RS13195	COG1595	DNA-templated transcription, initiation
NEB5A_RS13205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NEB5A_RS13215	COG0513	Belongs to the DEAD box helicase family
NEB5A_RS13225	COG0583	DNA-binding transcription factor activity
NEB5A_RS13245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEB5A_RS13255	COG3118	belongs to the thioredoxin family
NEB5A_RS13260	COG3148	PFAM DTW domain containing protein
NEB5A_RS13265	COG0045	succinate-CoA ligase (ADP-forming) activity
NEB5A_RS13265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEB5A_RS13265	COG1042	CoA-binding domain protein
NEB5A_RS13270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NEB5A_RS13275	COG5544	Lipoprotein
NEB5A_RS13280	COG0477	Major facilitator Superfamily
NEB5A_RS13310	COG0542	response to heat
NEB5A_RS13315	COG1496	oxidoreductase activity
NEB5A_RS13320	COG0564	pseudouridine synthase activity
NEB5A_RS13325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEB5A_RS13335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NEB5A_RS13340	COG1605	Chorismate mutase
NEB5A_RS13340	COG0077	Prephenate dehydratase
NEB5A_RS13345	COG1605	Chorismate mutase
NEB5A_RS13345	COG0287	Prephenate dehydrogenase
NEB5A_RS13350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NEB5A_RS13365	COG2199	diguanylate cyclase activity
NEB5A_RS13370	COG2885	chlorophyll binding
NEB5A_RS13395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NEB5A_RS13400	COG4137	Cytochrome C assembly protein
NEB5A_RS13405	COG4536	flavin adenine dinucleotide binding
NEB5A_RS13425	COG0497	DNA recombination
NEB5A_RS13430	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEB5A_RS13440	COG2867	negative regulation of translational initiation
NEB5A_RS13455	COG0582	viral genome integration into host DNA
NEB5A_RS13465	COG3311	Transcriptional regulator
NEB5A_RS13470	COG4983	Phage plasmid primase, P4 family domain protein
NEB5A_RS13480	COG1204	response to ionizing radiation
NEB5A_RS13490	COG1479	Protein of unknown function DUF262
NEB5A_RS13505	COG3596	GTP binding
NEB5A_RS13515	COG2378	regulation of single-species biofilm formation
NEB5A_RS13555	COG2003	Belongs to the UPF0758 family
NEB5A_RS13570	COG3468	outer membrane autotransporter barrel domain protein
NEB5A_RS13590	COG0366	Alpha amylase catalytic
NEB5A_RS13595	COG0366	Alpha amylase catalytic
NEB5A_RS13600	COG0366	Alpha amylase catalytic
NEB5A_RS13610	COG0579	oxidoreductase
NEB5A_RS13615	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS13620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NEB5A_RS13625	COG1113	amino acid transport
NEB5A_RS13630	COG1802	Transcriptional regulator
NEB5A_RS13635	COG1652	LysM domain
NEB5A_RS13640	COG0401	homolog of Blt101
NEB5A_RS13645	COG0640	Transcriptional regulator
NEB5A_RS13650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEB5A_RS13655	COG2916	Histone family protein nucleoid-structuring protein H-NS
NEB5A_RS13670	COG4575	ribosome binding
NEB5A_RS13675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NEB5A_RS13685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEB5A_RS13690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEB5A_RS13695	COG4175	Glycine betaine
NEB5A_RS13700	COG4176	ABC-type proline glycine betaine transport system permease component
NEB5A_RS13705	COG2113	Glycine betaine
NEB5A_RS13715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NEB5A_RS13725	COG1846	Transcriptional regulator
NEB5A_RS13730	COG1566	PFAM secretion protein HlyD family protein
NEB5A_RS13735	COG2814	Major facilitator Superfamily
NEB5A_RS13750	COG1238	metal cluster binding
NEB5A_RS13755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEB5A_RS13785	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NEB5A_RS13810	COG1546	Belongs to the CinA family
NEB5A_RS13815	COG2951	lytic endotransglycosylase activity
NEB5A_RS13820	COG3730	PTS system glucitol sorbitol-specific
NEB5A_RS13825	COG3732	PTS system glucitol sorbitol-specific
NEB5A_RS13830	COG3731	PTS system glucitol sorbitol-specific IIA component
NEB5A_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS13840	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS13845	COG1349	DNA-binding transcription factor activity
NEB5A_RS13850	COG0517	IMP dehydrogenase activity
NEB5A_RS13850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NEB5A_RS13870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NEB5A_RS13875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS13880	COG1609	Transcriptional regulator
NEB5A_RS13885	COG1263	PTS System
NEB5A_RS13885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS13890	COG2723	6-phospho-beta-galactosidase activity
NEB5A_RS13895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NEB5A_RS13905	COG3260	NADH ubiquinone oxidoreductase 20
NEB5A_RS13910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NEB5A_RS13915	COG3261	NADH dehydrogenase
NEB5A_RS13915	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NEB5A_RS13920	COG0650	Formate hydrogenlyase subunit 4
NEB5A_RS13925	COG0651	ATP synthesis coupled electron transport
NEB5A_RS13930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS13945	COG0375	protein maturation
NEB5A_RS13950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NEB5A_RS13955	COG0298	carbon dioxide binding
NEB5A_RS13960	COG0409	Hydrogenase expression formation protein
NEB5A_RS13965	COG0309	Hydrogenase expression formation protein (HypE)
NEB5A_RS13970	COG3604	Transcriptional regulator
NEB5A_RS13985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NEB5A_RS13990	COG1349	DNA-binding transcription factor activity
NEB5A_RS13995	COG2084	Dehydrogenase
NEB5A_RS14000	COG3395	kinase activity
NEB5A_RS14005	COG0235	Class ii aldolase
NEB5A_RS14010	COG3622	Belongs to the hyi family
NEB5A_RS14015	COG2610	gluconate transmembrane transporter activity
NEB5A_RS14020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NEB5A_RS14025	COG1388	LysM domain
NEB5A_RS14025	COG4942	peptidase
NEB5A_RS14080	COG2234	aminopeptidase activity
NEB5A_RS14085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEB5A_RS14090	COG1518	maintenance of DNA repeat elements
NEB5A_RS14105	COG1857	crispr-associated protein
NEB5A_RS14120	COG1203	CRISPR-associated helicase, Cas3
NEB5A_RS14135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NEB5A_RS14140	COG0720	synthase
NEB5A_RS14145	COG0644	oxidoreductase
NEB5A_RS14150	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NEB5A_RS14155	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NEB5A_RS14160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NEB5A_RS14165	COG2086	electron transfer activity
NEB5A_RS14170	COG0477	Major facilitator Superfamily
NEB5A_RS14175	COG0277	FAD linked oxidase domain protein
NEB5A_RS14180	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS14185	COG2223	nitrite transmembrane transporter activity
NEB5A_RS14190	COG1070	Carbohydrate kinase
NEB5A_RS14195	COG0602	queuosine metabolic process
NEB5A_RS14205	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NEB5A_RS14220	COG3956	TIGRFAM MazG family protein
NEB5A_RS14225	COG2337	Toxic component of a toxin-antitoxin (TA) module
NEB5A_RS14230	COG2336	PFAM SpoVT AbrB
NEB5A_RS14235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NEB5A_RS14240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NEB5A_RS14245	COG3850	Histidine kinase
NEB5A_RS14245	COG2205	protein histidine kinase activity
NEB5A_RS14245	COG4999	Histidine kinase
NEB5A_RS14245	COG3437	response regulator, receiver
NEB5A_RS14250	COG4948	Mandelate Racemase Muconate Lactonizing
NEB5A_RS14255	COG4948	Mandelate Racemase Muconate Lactonizing
NEB5A_RS14260	COG2271	Major facilitator Superfamily
NEB5A_RS14265	COG0716	FMN binding
NEB5A_RS14270	COG0564	pseudouridine synthase activity
NEB5A_RS14275	COG3098	single-species biofilm formation
NEB5A_RS14295	COG1611	Belongs to the LOG family
NEB5A_RS14300	COG0814	amino acid
NEB5A_RS14305	COG1760	l-serine dehydratase
NEB5A_RS14315	COG1454	alcohol dehydrogenase
NEB5A_RS14320	COG0235	Class ii aldolase
NEB5A_RS14325	COG0738	Major facilitator superfamily
NEB5A_RS14335	COG1070	Carbohydrate kinase
NEB5A_RS14345	COG1349	DNA-binding transcription factor activity
NEB5A_RS14355	COG2363	Small membrane protein
NEB5A_RS14360	COG0583	DNA-binding transcription factor activity
NEB5A_RS14370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NEB5A_RS14375	COG2166	iron-sulfur cluster assembly
NEB5A_RS14380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NEB5A_RS14385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NEB5A_RS14405	COG0860	N-Acetylmuramoyl-L-alanine amidase
NEB5A_RS14410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NEB5A_RS14410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NEB5A_RS14415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NEB5A_RS14420	COG1074	ATP-dependent DNA helicase activity
NEB5A_RS14425	COG1025	Belongs to the peptidase M16 family
NEB5A_RS14430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NEB5A_RS14435	COG4967	type IV pilus modification protein PilV
NEB5A_RS14445	COG4795	General secretion pathway protein
NEB5A_RS14450	COG2165	general secretion pathway protein
NEB5A_RS14465	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
NEB5A_RS14490	COG0861	Integral membrane protein TerC family
NEB5A_RS14500	COG0667	Aldo Keto reductase
NEB5A_RS14515	COG1609	Transcriptional regulator
NEB5A_RS14525	COG0583	DNA-binding transcription factor activity
NEB5A_RS14530	COG1794	racemase activity, acting on amino acids and derivatives
NEB5A_RS14535	COG2814	Major facilitator Superfamily
NEB5A_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS14550	COG0183	Belongs to the thiolase family
NEB5A_RS14555	COG0814	amino acid
NEB5A_RS14560	COG2771	luxR family
NEB5A_RS14565	COG3710	Transcriptional regulator
NEB5A_RS14585	COG0457	Tetratricopeptide repeat
NEB5A_RS14590	COG0457	Tetratricopeptide repeat
NEB5A_RS14590	COG3710	Transcriptional regulator
NEB5A_RS14605	COG2197	response regulator
NEB5A_RS14610	COG2197	response regulator
NEB5A_RS14640	COG3387	PFAM Glycoside hydrolase 15-related
NEB5A_RS14645	COG3387	PFAM Glycoside hydrolase 15-related
NEB5A_RS14655	COG4942	peptidase
NEB5A_RS14660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NEB5A_RS14665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NEB5A_RS14670	COG2080	2 iron, 2 sulfur cluster binding
NEB5A_RS14675	COG3829	transcription factor binding
NEB5A_RS14680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NEB5A_RS14685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEB5A_RS14690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEB5A_RS14700	COG0549	Belongs to the carbamate kinase family
NEB5A_RS14705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NEB5A_RS14705	COG3608	succinylglutamate desuccinylase aspartoacylase
NEB5A_RS14710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NEB5A_RS14715	COG2068	MobA-Related Protein
NEB5A_RS14720	COG0493	'glutamate synthase
NEB5A_RS14720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS14725	COG0402	S-adenosylhomocysteine deaminase activity
NEB5A_RS14730	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NEB5A_RS14735	COG2080	2 iron, 2 sulfur cluster binding
NEB5A_RS14735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NEB5A_RS14740	COG2233	PERMEase
NEB5A_RS14745	COG0402	S-adenosylhomocysteine deaminase activity
NEB5A_RS14750	COG2252	PERMEase
NEB5A_RS14755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS14760	COG0493	'glutamate synthase
NEB5A_RS14760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS14770	COG2233	PERMEase
NEB5A_RS14785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NEB5A_RS14795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NEB5A_RS14800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NEB5A_RS14805	COG4974	Belongs to the 'phage' integrase family
NEB5A_RS14810	COG0716	FMN binding
NEB5A_RS14820	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NEB5A_RS14830	COG1272	protein, Hemolysin III
NEB5A_RS14840	COG2723	6-phospho-beta-galactosidase activity
NEB5A_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS14865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEB5A_RS14870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEB5A_RS14875	COG0006	proline dipeptidase activity
NEB5A_RS14895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NEB5A_RS14900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NEB5A_RS14920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEB5A_RS14920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NEB5A_RS14925	COG1703	isobutyryl-CoA mutase activity
NEB5A_RS14930	COG1024	Enoyl-CoA hydratase
NEB5A_RS14935	COG0427	acetyl-CoA hydrolase
NEB5A_RS14940	COG0583	DNA-binding transcription factor activity
NEB5A_RS14945	COG2968	Membrane
NEB5A_RS14950	COG1279	arginine transmembrane transporter activity
NEB5A_RS14955	COG0668	transmembrane transport
NEB5A_RS14960	COG0191	fructose-bisphosphate aldolase activity
NEB5A_RS14975	COG1072	(Pantothenic acid kinase))
NEB5A_RS14980	COG3722	fumarate hydratase activity
NEB5A_RS14985	COG1494	fructose-1,6-bisphosphatase
NEB5A_RS14990	COG1063	alcohol dehydrogenase
NEB5A_RS14995	COG2213	PTS system mannitol-specific
NEB5A_RS15000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS15005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NEB5A_RS15010	COG0501	Belongs to the peptidase M48B family
NEB5A_RS15020	COG1166	arginine decarboxylase activity
NEB5A_RS15045	COG2814	Major facilitator Superfamily
NEB5A_RS15055	COG2356	endonuclease I
NEB5A_RS15060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NEB5A_RS15065	COG0189	ligase activity
NEB5A_RS15080	COG2805	Type II/IV secretion system protein
NEB5A_RS15085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NEB5A_RS15090	COG0762	integral membrane protein
NEB5A_RS15100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NEB5A_RS15105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NEB5A_RS15115	COG0252	asparaginase activity
NEB5A_RS15130	COG3171	Protein conserved in bacteria
NEB5A_RS15140	COG1194	a g-specific adenine glycosylase
NEB5A_RS15155	COG2211	Major facilitator Superfamily
NEB5A_RS15160	COG1982	Orn Lys Arg decarboxylase major
NEB5A_RS15165	COG1811	Na channel or pump
NEB5A_RS15175	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NEB5A_RS15185	COG3031	protein transport across the cell outer membrane
NEB5A_RS15195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NEB5A_RS15200	COG3064	Membrane
NEB5A_RS15210	COG1620	l-lactate permease
NEB5A_RS15215	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NEB5A_RS15220	COG3193	protein, possibly involved in utilization of glycolate and propanediol
NEB5A_RS15225	COG0247	lactate metabolic process
NEB5A_RS15230	COG0277	FAD linked oxidase domain protein
NEB5A_RS15235	COG0277	FAD linked oxidase domain protein
NEB5A_RS15240	COG2186	Transcriptional regulator
NEB5A_RS15245	COG0456	acetyltransferase
NEB5A_RS15255	COG2244	polysaccharide biosynthetic process
NEB5A_RS15260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NEB5A_RS15265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NEB5A_RS15270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NEB5A_RS15275	COG0306	phosphate transporter
NEB5A_RS15280	COG0754	glutathionylspermidine amidase activity
NEB5A_RS15285	COG0625	glutathione transferase activity
NEB5A_RS15290	COG0298	carbon dioxide binding
NEB5A_RS15300	COG1773	rubredoxin
NEB5A_RS15305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NEB5A_RS15310	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NEB5A_RS15315	COG5557	Pfam Polysulphide reductase, NrfD
NEB5A_RS15320	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS15325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NEB5A_RS15345	COG0667	Aldo Keto reductase
NEB5A_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS15360	COG0848	biopolymer transport protein
NEB5A_RS15365	COG0811	peptide transport
NEB5A_RS15375	COG0626	cystathionine gamma-synthase activity
NEB5A_RS15380	COG0586	Pfam SNARE associated Golgi protein
NEB5A_RS15385	COG2207	Transcriptional regulator
NEB5A_RS15395	COG1979	alcohol dehydrogenase
NEB5A_RS15400	COG0656	L-ascorbic acid biosynthetic process
NEB5A_RS15410	COG4238	major outer membrane lipoprotein
NEB5A_RS15415	COG1032	radical SAM domain protein
NEB5A_RS15425	COG0204	Acyl-transferase
NEB5A_RS15430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NEB5A_RS15435	COG4166	transmembrane transport
NEB5A_RS15440	COG2944	sequence-specific DNA binding
NEB5A_RS15450	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NEB5A_RS15455	COG3111	PFAM Bacterial OB fold (BOF) protein
NEB5A_RS15460	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS15465	COG0642	Histidine kinase
NEB5A_RS15475	COG2249	NAD(P)H dehydrogenase (quinone) activity
NEB5A_RS15480	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NEB5A_RS15485	COG0187	DNA topoisomerase II activity
NEB5A_RS15490	COG3150	esterase
NEB5A_RS15495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NEB5A_RS15500	COG3151	Protein conserved in bacteria
NEB5A_RS15505	COG0494	nUDIX hydrolase
NEB5A_RS15510	COG1538	Outer membrane efflux protein
NEB5A_RS15525	COG0754	glutathionylspermidine amidase activity
NEB5A_RS15530	COG3384	dioxygenase
NEB5A_RS15550	COG2960	long-chain fatty acid transporting porin activity
NEB5A_RS15555	COG3539	Fimbrial protein
NEB5A_RS15570	COG3188	usher protein
NEB5A_RS15575	COG3121	Chaperone
NEB5A_RS15580	COG3539	Fimbrial protein
NEB5A_RS15590	COG1585	Membrane protein implicated in regulation of membrane protease activity
NEB5A_RS15595	COG2268	Band 7 protein
NEB5A_RS15620	COG3025	triphosphatase activity
NEB5A_RS15630	COG4991	sh3 domain protein
NEB5A_RS15645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NEB5A_RS15655	COG0583	DNA-binding transcription factor activity
NEB5A_RS15660	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NEB5A_RS15670	COG0471	metal ion transport
NEB5A_RS15680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NEB5A_RS15685	COG0358	DNA primase activity
NEB5A_RS15690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NEB5A_RS15705	COG2375	cellular response to nickel ion
NEB5A_RS15710	COG1695	Transcriptional regulator
NEB5A_RS15715	COG0840	transmembrane signaling receptor activity
NEB5A_RS15725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEB5A_RS15730	COG1609	Transcriptional regulator
NEB5A_RS15735	COG3250	beta-galactosidase activity
NEB5A_RS15740	COG2731	YhcH YjgK YiaL family protein
NEB5A_RS15745	COG0531	amino acid
NEB5A_RS15755	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
NEB5A_RS15755	COG3408	Glycogen debranching enzyme
NEB5A_RS15760	COG1902	pentaerythritol trinitrate reductase activity
NEB5A_RS15760	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEB5A_RS15765	COG5499	transcription regulator containing HTH domain
NEB5A_RS15770	COG4680	protein conserved in bacteria
NEB5A_RS15785	COG1451	nucleotide metabolic process
NEB5A_RS15790	COG2949	membrane
NEB5A_RS15795	COG0673	inositol 2-dehydrogenase activity
NEB5A_RS15800	COG0861	Integral membrane protein TerC family
NEB5A_RS15805	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
NEB5A_RS15815	COG2721	sulfolactate sulfo-lyase activity
NEB5A_RS15825	COG2271	Major facilitator Superfamily
NEB5A_RS15830	COG2186	Transcriptional regulator
NEB5A_RS15835	COG0586	Pfam SNARE associated Golgi protein
NEB5A_RS15845	COG1422	Protein of unknown function (DUF1090)
NEB5A_RS15850	COG4575	ribosome binding
NEB5A_RS15855	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
NEB5A_RS15865	COG2259	Doxx family
NEB5A_RS15870	COG0435	Glutathione S-transferase
NEB5A_RS15875	COG3152	Membrane
NEB5A_RS15880	COG3152	Membrane
NEB5A_RS15885	COG0583	DNA-binding transcription factor activity
NEB5A_RS15890	COG1741	Belongs to the pirin family
NEB5A_RS15905	COG0814	amino acid
NEB5A_RS15910	COG1760	l-serine dehydratase
NEB5A_RS15915	COG0251	oxidation-reduction process
NEB5A_RS15920	COG1882	Formate acetyltransferase
NEB5A_RS15925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NEB5A_RS15935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEB5A_RS15940	COG0583	DNA-binding transcription factor activity
NEB5A_RS15965	COG1929	Belongs to the glycerate kinase type-1 family
NEB5A_RS15970	COG2084	Dehydrogenase
NEB5A_RS15980	COG2271	Major facilitator Superfamily
NEB5A_RS15985	COG2721	sulfolactate sulfo-lyase activity
NEB5A_RS15990	COG2002	toxin-antitoxin pair type II binding
NEB5A_RS16000	COG1349	DNA-binding transcription factor activity
NEB5A_RS16010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS16020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NEB5A_RS16025	COG2222	sugar isomerase
NEB5A_RS16035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS16040	COG3715	PTS system
NEB5A_RS16045	COG3716	PTS system mannose fructose sorbose family IID component
NEB5A_RS16050	COG0363	glucosamine-6-phosphate deaminase activity
NEB5A_RS16055	COG3539	Fimbrial protein
NEB5A_RS16060	COG3121	Chaperone
NEB5A_RS16065	COG3188	usher protein
NEB5A_RS16070	COG3539	Fimbrial protein
NEB5A_RS16075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NEB5A_RS16080	COG3107	peptidoglycan biosynthetic process
NEB5A_RS16095	COG2823	Periplasmic or secreted lipoprotein
NEB5A_RS16100	COG0701	Predicted permease
NEB5A_RS16105	COG0702	epimerase
NEB5A_RS16110	COG0693	protein deglycase activity
NEB5A_RS16125	COG3153	acetyltransferase
NEB5A_RS16130	COG3154	lipid carrier protein
NEB5A_RS16135	COG0826	peptidase U32
NEB5A_RS16140	COG0826	peptidase U32
NEB5A_RS16145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEB5A_RS16150	COG0814	amino acid
NEB5A_RS16160	COG0513	Belongs to the DEAD box helicase family
NEB5A_RS16195	COG0195	Participates in both transcription termination and antitermination
NEB5A_RS16215	COG2194	sulfuric ester hydrolase activity
NEB5A_RS16225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NEB5A_RS16235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NEB5A_RS16240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NEB5A_RS16250	COG1534	Rna-binding protein
NEB5A_RS16255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NEB5A_RS16260	COG2027	D-alanyl-D-alanine carboxypeptidase
NEB5A_RS16270	COG0697	spore germination
NEB5A_RS16285	COG0142	geranyltranstransferase activity
NEB5A_RS16290	COG3423	Transcriptional regulator
NEB5A_RS16300	COG5007	Belongs to the BolA IbaG family
NEB5A_RS16305	COG3113	response to antibiotic
NEB5A_RS16310	COG2854	intermembrane phospholipid transfer
NEB5A_RS16315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NEB5A_RS16320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NEB5A_RS16325	COG1127	ABC transporter
NEB5A_RS16330	COG0530	calcium, potassium:sodium antiporter activity
NEB5A_RS16335	COG0517	IMP dehydrogenase activity
NEB5A_RS16335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NEB5A_RS16340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NEB5A_RS16345	COG3117	lipopolysaccharide transmembrane transporter activity
NEB5A_RS16350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NEB5A_RS16355	COG1137	ATPase activity
NEB5A_RS16360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NEB5A_RS16365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NEB5A_RS16380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS16385	COG0515	serine threonine protein kinase
NEB5A_RS16395	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NEB5A_RS16400	COG0784	Response regulator, receiver
NEB5A_RS16400	COG2198	Histidine kinase
NEB5A_RS16400	COG5002	protein histidine kinase activity
NEB5A_RS16405	COG1242	4 iron, 4 sulfur cluster binding
NEB5A_RS16410	COG0067	glutamate synthase
NEB5A_RS16410	COG0069	glutamate synthase activity
NEB5A_RS16410	COG0070	glutamate synthase
NEB5A_RS16415	COG0493	'glutamate synthase
NEB5A_RS16420	COG3539	Fimbrial protein
NEB5A_RS16425	COG3121	Chaperone
NEB5A_RS16430	COG3188	usher protein
NEB5A_RS16450	COG3539	Fimbrial protein
NEB5A_RS16455	COG4804	nuclease activity
NEB5A_RS16460	COG2731	YhcH YjgK YiaL family protein
NEB5A_RS16490	COG3069	C4-dicarboxylate transmembrane transporter activity
NEB5A_RS16495	COG2969	positive regulation of protein catabolic process
NEB5A_RS16500	COG0625	glutathione transferase activity
NEB5A_RS16515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NEB5A_RS16520	COG3105	Protein conserved in bacteria
NEB5A_RS16525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEB5A_RS16530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEB5A_RS16550	COG2732	(Barnase) inhibitor
NEB5A_RS16570	COG0583	DNA-binding transcription factor activity
NEB5A_RS16575	COG0312	modulator of DNA gyrase
NEB5A_RS16580	COG3164	Protein of unknown function
NEB5A_RS16585	COG1530	ribonuclease E activity
NEB5A_RS16590	COG0424	maF-like protein
NEB5A_RS16595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NEB5A_RS16600	COG1792	Involved in formation and maintenance of cell shape
NEB5A_RS16605	COG1077	Cell shape determining protein MreB Mrl
NEB5A_RS16615	COG2199	diguanylate cyclase activity
NEB5A_RS16615	COG2200	EAL domain
NEB5A_RS16620	COG0604	alcohol dehydrogenase
NEB5A_RS16640	COG0511	ligase activity, forming carbon-carbon bonds
NEB5A_RS16645	COG0439	Biotin carboxylase
NEB5A_RS16650	COG3924	membrane
NEB5A_RS16655	COG4145	pantothenate transmembrane transporter activity
NEB5A_RS16665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NEB5A_RS16675	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NEB5A_RS16685	COG1309	transcriptional regulator
NEB5A_RS16690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS16695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEB5A_RS16710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEB5A_RS16715	COG4597	amino acid ABC transporter
NEB5A_RS16720	COG0765	amino acid transport
NEB5A_RS16725	COG1126	abc transporter atp-binding protein
NEB5A_RS16765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NEB5A_RS16785	COG0551	DNA topoisomerase type I activity
NEB5A_RS16795	COG0758	DNA mediated transformation
NEB5A_RS16815	COG0569	domain protein
NEB5A_RS16825	COG3036	rescue of stalled ribosome
NEB5A_RS16830	COG0789	Transcriptional regulator
NEB5A_RS16870	COG0201	protein transport
NEB5A_RS16960	COG0089	rRNA binding
NEB5A_RS16985	COG3267	Type II secretory pathway component ExeA
NEB5A_RS16985	COG3409	Peptidoglycan-binding domain 1 protein
NEB5A_RS16990	COG3031	protein transport across the cell outer membrane
NEB5A_RS16995	COG1450	Type ii and iii secretion system protein
NEB5A_RS17000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NEB5A_RS17005	COG1459	type II secretion system
NEB5A_RS17010	COG2165	general secretion pathway protein
NEB5A_RS17015	COG2165	general secretion pathway protein
NEB5A_RS17020	COG2165	general secretion pathway protein
NEB5A_RS17025	COG4795	General secretion pathway protein
NEB5A_RS17030	COG3156	type II secretion system protein K
NEB5A_RS17035	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NEB5A_RS17040	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
NEB5A_RS17045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NEB5A_RS17050	COG2193	ferroxidase activity
NEB5A_RS17055	COG2906	2 iron, 2 sulfur cluster binding
NEB5A_RS17060	COG3979	chitinase
NEB5A_RS17100	COG2964	Protein conserved in bacteria
NEB5A_RS17105	COG0545	Peptidyl-prolyl cis-trans isomerase
NEB5A_RS17115	COG1047	Peptidyl-prolyl cis-trans
NEB5A_RS17120	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NEB5A_RS17135	COG0488	(ABC) transporter
NEB5A_RS17140	COG0429	hydrolase of the alpha beta-hydrolase fold
NEB5A_RS17150	COG3954	Phosphoribulokinase
NEB5A_RS17155	COG1765	OsmC-like protein
NEB5A_RS17165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEB5A_RS17170	COG1289	transmembrane transporter activity
NEB5A_RS17175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NEB5A_RS17180	COG0512	Glutamine amidotransferase of anthranilate synthase
NEB5A_RS17185	COG2184	nucleotidyltransferase activity
NEB5A_RS17195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NEB5A_RS17205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NEB5A_RS17210	COG2146	nitrite reductase [NAD(P)H] activity
NEB5A_RS17215	COG2116	formate transmembrane transporter activity
NEB5A_RS17230	COG0531	amino acid
NEB5A_RS17235	COG2222	sugar isomerase
NEB5A_RS17240	COG1082	Xylose isomerase domain protein TIM barrel
NEB5A_RS17245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS17250	COG2188	Transcriptional regulator
NEB5A_RS17255	COG0626	cystathionine gamma-synthase activity
NEB5A_RS17270	COG1735	metal-dependent hydrolase with the TIM-barrel fold
NEB5A_RS17275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NEB5A_RS17280	COG3457	Alanine racemase
NEB5A_RS17290	COG2188	Transcriptional regulator
NEB5A_RS17295	COG0180	Tryptophanyl-tRNA synthetase
NEB5A_RS17300	COG0546	phosphoglycolate phosphatase activity
NEB5A_RS17305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NEB5A_RS17310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NEB5A_RS17315	COG3266	domain, Protein
NEB5A_RS17330	COG4796	Type ii and iii secretion system protein
NEB5A_RS17345	COG3166	PFAM Fimbrial assembly family protein
NEB5A_RS17350	COG4972	Pilus assembly protein
NEB5A_RS17355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NEB5A_RS17360	COG0494	nUDIX hydrolase
NEB5A_RS17370	COG1011	Hydrolase
NEB5A_RS17375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NEB5A_RS17385	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NEB5A_RS17410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NEB5A_RS17415	COG2183	response to ionizing radiation
NEB5A_RS17420	COG1918	ferrous iron import across plasma membrane
NEB5A_RS17425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NEB5A_RS17435	COG5464	transposase or invertase
NEB5A_RS17445	COG1040	competence protein
NEB5A_RS17455	COG2610	gluconate transmembrane transporter activity
NEB5A_RS17460	COG1640	4-alpha-glucanotransferase
NEB5A_RS17465	COG0058	SHG alpha-glucan phosphorylase activity
NEB5A_RS17480	COG1690	Belongs to the RtcB family
NEB5A_RS17485	COG4650	regulator
NEB5A_RS17490	COG1349	DNA-binding transcription factor activity
NEB5A_RS17505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NEB5A_RS17510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NEB5A_RS17515	COG0058	SHG alpha-glucan phosphorylase activity
NEB5A_RS17540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NEB5A_RS17545	COG2095	MarC family integral membrane protein
NEB5A_RS17550	COG2610	gluconate transmembrane transporter activity
NEB5A_RS17555	COG3265	gluconokinase activity
NEB5A_RS17560	COG1609	Transcriptional regulator
NEB5A_RS17565	COG1741	Belongs to the pirin family
NEB5A_RS17570	COG0673	inositol 2-dehydrogenase activity
NEB5A_RS17575	COG1247	-acetyltransferase
NEB5A_RS17580	COG3157	Type VI secretion system effector, Hcp
NEB5A_RS17600	COG0405	Gamma-glutamyltransferase
NEB5A_RS17610	COG0584	glycerophosphoryl diester phosphodiesterase
NEB5A_RS17615	COG3842	ATPase activity
NEB5A_RS17620	COG0395	ABC-type sugar transport system, permease component
NEB5A_RS17625	COG1175	transmembrane transport
NEB5A_RS17630	COG1653	transport
NEB5A_RS17640	COG0410	ABC transporter
NEB5A_RS17645	COG0411	ABC transporter
NEB5A_RS17650	COG4177	L-phenylalanine transmembrane transporter activity
NEB5A_RS17655	COG0559	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS17660	COG0683	leucine binding
NEB5A_RS17665	COG0456	acetyltransferase
NEB5A_RS17675	COG0683	leucine binding
NEB5A_RS17680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NEB5A_RS17685	COG2177	Part of the ABC transporter FtsEX involved in
NEB5A_RS17690	COG2884	Cell division ATP-binding protein ftsE
NEB5A_RS17695	COG0552	protein localization to endoplasmic reticulum
NEB5A_RS17700	COG0742	ribosomal rna small subunit methyltransferase
NEB5A_RS17705	COG3776	membrane
NEB5A_RS17715	COG3714	YhhN family
NEB5A_RS17720	COG2217	Heavy metal translocating P-type atpase
NEB5A_RS17730	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NEB5A_RS17740	COG0477	Major facilitator Superfamily
NEB5A_RS17745	COG0628	permease
NEB5A_RS17750	COG2091	lysine biosynthetic process via aminoadipic acid
NEB5A_RS17755	COG0747	negative chemotaxis
NEB5A_RS17760	COG0601	transmembrane transport
NEB5A_RS17765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEB5A_RS17770	COG0444	Belongs to the ABC transporter superfamily
NEB5A_RS17775	COG1124	(ABC) transporter
NEB5A_RS17785	COG3209	COG3209 Rhs family protein
NEB5A_RS17800	COG5433	transposase activity
NEB5A_RS17805	COG0842	Transport permease protein
NEB5A_RS17810	COG0842	Transport permease protein
NEB5A_RS17810	COG1129	ABC transporter
NEB5A_RS17815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS17845	COG2081	HI0933 family
NEB5A_RS17850	COG0306	phosphate transporter
NEB5A_RS17860	COG0589	response to stress
NEB5A_RS17865	COG3104	oligopeptide transport
NEB5A_RS17875	COG0339	signal peptide processing
NEB5A_RS17880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NEB5A_RS17885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEB5A_RS17900	COG0640	Transcriptional regulator
NEB5A_RS17905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NEB5A_RS17910	COG1393	Belongs to the ArsC family
NEB5A_RS17930	COG3065	identical protein binding
NEB5A_RS17935	COG2197	response regulator
NEB5A_RS17940	COG1285	pathogenesis
NEB5A_RS17955	COG3247	response to pH
NEB5A_RS17960	COG2771	luxR family
NEB5A_RS17970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEB5A_RS17975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEB5A_RS17980	COG2207	Transcriptional regulator
NEB5A_RS17985	COG2207	Transcriptional regulator
NEB5A_RS17990	COG0076	glutamate decarboxylase activity
NEB5A_RS17995	COG1858	cytochrome C peroxidase
NEB5A_RS18005	COG2197	response regulator
NEB5A_RS18010	COG0583	DNA-binding transcription factor activity
NEB5A_RS18015	COG1295	ribonuclease BN
NEB5A_RS18020	COG0477	Major facilitator Superfamily
NEB5A_RS18025	COG2982	Protein involved in outer membrane biogenesis
NEB5A_RS18030	COG2200	EAL domain
NEB5A_RS18040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS18045	COG0612	Peptidase, M16
NEB5A_RS18055	COG2199	diguanylate cyclase activity
NEB5A_RS18055	COG2200	EAL domain
NEB5A_RS18060	COG0457	Tetratricopeptide repeat
NEB5A_RS18060	COG3118	belongs to the thioredoxin family
NEB5A_RS18065	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NEB5A_RS18070	COG1215	transferase activity, transferring glycosyl groups
NEB5A_RS18075	COG1215	transferase activity, transferring glycosyl groups
NEB5A_RS18100	COG2194	sulfuric ester hydrolase activity
NEB5A_RS18115	COG0814	amino acid
NEB5A_RS18120	COG4608	Belongs to the ABC transporter superfamily
NEB5A_RS18125	COG0444	Belongs to the ABC transporter superfamily
NEB5A_RS18130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEB5A_RS18135	COG0601	transmembrane transport
NEB5A_RS18145	COG0747	negative chemotaxis
NEB5A_RS18165	COG2194	sulfuric ester hydrolase activity
NEB5A_RS18170	COG2223	nitrite transmembrane transporter activity
NEB5A_RS18175	COG5571	outer membrane autotransporter
NEB5A_RS18180	COG2818	Glycosylase
NEB5A_RS18185	COG0456	acetyltransferase
NEB5A_RS18190	COG0243	molybdopterin cofactor binding
NEB5A_RS18195	COG2885	chlorophyll binding
NEB5A_RS18210	COG2944	sequence-specific DNA binding
NEB5A_RS18215	COG1278	Cold shock
NEB5A_RS18225	COG2963	transposase activity
NEB5A_RS18230	COG2801	Transposase and inactivated derivatives
NEB5A_RS18250	COG3274	enterobacterial common antigen metabolic process
NEB5A_RS18255	COG4682	membrane
NEB5A_RS18260	COG4682	membrane
NEB5A_RS18265	COG1070	Carbohydrate kinase
NEB5A_RS18275	COG4213	ABC transporter substrate-binding protein
NEB5A_RS18280	COG1129	ABC transporter
NEB5A_RS18285	COG4214	carbohydrate transport
NEB5A_RS18290	COG1609	Transcriptional regulator
NEB5A_RS18290	COG2207	Transcriptional regulator
NEB5A_RS18295	COG2992	FlgJ-related protein
NEB5A_RS18300	COG0366	Alpha amylase catalytic
NEB5A_RS18305	COG3977	Valine--pyruvate aminotransferase
NEB5A_RS18315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEB5A_RS18320	COG1414	Transcriptional regulator
NEB5A_RS18330	COG2731	YhcH YjgK YiaL family protein
NEB5A_RS18335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEB5A_RS18340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEB5A_RS18345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NEB5A_RS18350	COG1070	Carbohydrate kinase
NEB5A_RS18355	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NEB5A_RS18360	COG3623	hexulose-6-phosphate isomerase
NEB5A_RS18365	COG0235	Class ii aldolase
NEB5A_RS18370	COG3713	MltA-interacting MipA family protein
NEB5A_RS18375	COG0583	DNA-binding transcription factor activity
NEB5A_RS18380	COG1566	PFAM secretion protein HlyD family protein
NEB5A_RS18395	COG1012	belongs to the aldehyde dehydrogenase family
NEB5A_RS18400	COG1454	alcohol dehydrogenase
NEB5A_RS18405	COG3276	selenocysteine insertion sequence binding
NEB5A_RS18415	COG0625	glutathione transferase activity
NEB5A_RS18420	COG3209	COG3209 Rhs family protein
NEB5A_RS18425	COG1413	lyase activity
NEB5A_RS18430	COG3209	COG3209 Rhs family protein
NEB5A_RS18435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NEB5A_RS18445	COG1566	PFAM secretion protein HlyD family protein
NEB5A_RS18455	COG2213	PTS system mannitol-specific
NEB5A_RS18455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS18465	COG3722	fumarate hydratase activity
NEB5A_RS18480	COG1620	l-lactate permease
NEB5A_RS18485	COG2186	Transcriptional regulator
NEB5A_RS18495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NEB5A_RS18500	COG1045	serine acetyltransferase
NEB5A_RS18515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NEB5A_RS18520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEB5A_RS18525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NEB5A_RS18530	COG4942	peptidase
NEB5A_RS18535	COG2861	carbohydrate metabolic process
NEB5A_RS18540	COG1216	Glycosyl transferase, family 2
NEB5A_RS18550	COG0156	8-amino-7-oxononanoate synthase activity
NEB5A_RS18565	COG0859	PFAM glycosyl transferase family 9
NEB5A_RS18570	COG0859	PFAM glycosyl transferase family 9
NEB5A_RS18575	COG3307	-O-antigen
NEB5A_RS18580	COG0859	PFAM glycosyl transferase family 9
NEB5A_RS18590	COG3642	lipopolysaccharide core region biosynthetic process
NEB5A_RS18595	COG1442	glycosyl transferase family 8
NEB5A_RS18600	COG1442	glycosyl transferase family 8
NEB5A_RS18605	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS18610	COG4641	Protein conserved in bacteria
NEB5A_RS18610	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS18615	COG0515	serine threonine protein kinase
NEB5A_RS18620	COG0438	transferase activity, transferring glycosyl groups
NEB5A_RS18625	COG0859	PFAM glycosyl transferase family 9
NEB5A_RS18630	COG1519	Transferase
NEB5A_RS18660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NEB5A_RS18665	COG0756	dUTP diphosphatase activity
NEB5A_RS18685	COG1561	YicC-like family, N-terminal region
NEB5A_RS18690	COG3645	SOS response
NEB5A_RS18695	COG2860	membrane
NEB5A_RS18705	COG0194	GDP metabolic process
NEB5A_RS18715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NEB5A_RS18720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEB5A_RS18725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NEB5A_RS18730	COG0786	glutamate:sodium symporter activity
NEB5A_RS18735	COG2233	PERMEase
NEB5A_RS18740	COG2982	Protein involved in outer membrane biogenesis
NEB5A_RS18745	COG1501	Belongs to the glycosyl hydrolase 31 family
NEB5A_RS18750	COG2211	Major facilitator Superfamily
NEB5A_RS18765	COG2814	Major facilitator Superfamily
NEB5A_RS18770	COG0697	spore germination
NEB5A_RS18775	COG1464	Belongs to the NlpA lipoprotein family
NEB5A_RS18800	COG2252	PERMEase
NEB5A_RS18810	COG2271	Major facilitator Superfamily
NEB5A_RS18815	COG2271	Major facilitator Superfamily
NEB5A_RS18820	COG3851	Histidine kinase
NEB5A_RS18825	COG2197	response regulator
NEB5A_RS18830	COG0440	acetolactate synthase activity
NEB5A_RS18835	COG0028	Belongs to the TPP enzyme family
NEB5A_RS18860	COG2814	Major facilitator Superfamily
NEB5A_RS18865	COG0641	radical SAM
NEB5A_RS18875	COG2149	membrane
NEB5A_RS18885	COG3119	arylsulfatase activity
NEB5A_RS18890	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEB5A_RS18895	COG2207	Transcriptional regulator
NEB5A_RS18905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS18905	COG1263	PTS System
NEB5A_RS18910	COG1263	PTS System
NEB5A_RS18915	COG2188	Transcriptional regulator
NEB5A_RS18935	COG5645	(Lipo)protein
NEB5A_RS18940	COG0823	Involved in the tonB-independent uptake of proteins
NEB5A_RS18945	COG0644	oxidoreductase
NEB5A_RS18950	COG2271	Major facilitator Superfamily
NEB5A_RS18960	COG0800	Aldolase
NEB5A_RS18965	COG3734	2-keto-3-deoxy-galactonokinase
NEB5A_RS18970	COG2186	Transcriptional regulator
NEB5A_RS18980	COG0561	phosphatase activity
NEB5A_RS18985	COG3753	Protein conserved in bacteria
NEB5A_RS18995	COG0187	DNA topoisomerase II activity
NEB5A_RS19005	COG0592	DNA-directed DNA polymerase activity
NEB5A_RS19050	COG0814	amino acid
NEB5A_RS19065	COG2091	lysine biosynthetic process via aminoadipic acid
NEB5A_RS19070	COG0431	NADPH-dependent FMN reductase
NEB5A_RS19075	COG2252	PERMEase
NEB5A_RS19080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEB5A_RS19090	COG3196	Protein conserved in bacteria
NEB5A_RS19095	COG0363	glucosamine-6-phosphate deaminase activity
NEB5A_RS19100	COG2382	esterase
NEB5A_RS19110	COG2723	6-phospho-beta-galactosidase activity
NEB5A_RS19115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS19115	COG1263	PTS System
NEB5A_RS19115	COG2190	(PTS) system
NEB5A_RS19120	COG3711	transcriptional antiterminator
NEB5A_RS19125	COG0704	Plays a role in the regulation of phosphate uptake
NEB5A_RS19130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NEB5A_RS19135	COG0581	inorganic phosphate transmembrane transporter activity
NEB5A_RS19140	COG0573	inorganic phosphate transmembrane transporter activity
NEB5A_RS19145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NEB5A_RS19150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NEB5A_RS19200	COG3312	ion transport
NEB5A_RS19215	COG0716	FMN binding
NEB5A_RS19220	COG1522	sequence-specific DNA binding
NEB5A_RS19250	COG1129	ABC transporter
NEB5A_RS19255	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS19260	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS19265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS19275	COG0477	Major facilitator Superfamily
NEB5A_RS19280	COG2186	Transcriptional regulator
NEB5A_RS19320	COG3085	chromosome segregation
NEB5A_RS19325	COG0606	chelatase, subunit chli
NEB5A_RS19340	COG3978	acetolactate synthase activity
NEB5A_RS19345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NEB5A_RS19355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEB5A_RS19360	COG0583	DNA-binding transcription factor activity
NEB5A_RS19370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NEB5A_RS19380	COG0210	DNA helicase
NEB5A_RS19395	COG3118	belongs to the thioredoxin family
NEB5A_RS19405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NEB5A_RS19415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NEB5A_RS19420	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
NEB5A_RS19425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NEB5A_RS19430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NEB5A_RS19435	COG1088	dTDP-glucose 4,6-dehydratase activity
NEB5A_RS19440	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NEB5A_RS19445	COG0456	acetyltransferase
NEB5A_RS19450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NEB5A_RS19455	COG2244	polysaccharide biosynthetic process
NEB5A_RS19475	COG1113	amino acid transport
NEB5A_RS19500	COG0641	radical SAM
NEB5A_RS19505	COG3119	arylsulfatase activity
NEB5A_RS19510	COG3071	HemY protein
NEB5A_RS19515	COG2959	enzyme of heme biosynthesis
NEB5A_RS19520	COG1587	Uroporphyrinogen-III synthase
NEB5A_RS19530	COG3072	Adenylate cyclase
NEB5A_RS19540	COG5567	small periplasmic lipoprotein
NEB5A_RS19550	COG3159	Protein conserved in bacteria
NEB5A_RS19560	COG1011	Hydrolase
NEB5A_RS19565	COG0210	DNA helicase
NEB5A_RS19570	COG3698	Phosphodiester glycosidase
NEB5A_RS19580	COG0598	Magnesium transport protein CorA
NEB5A_RS19595	COG2962	Rard protein
NEB5A_RS19600	COG2050	protein possibly involved in aromatic compounds catabolism
NEB5A_RS19605	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
NEB5A_RS19610	COG0514	ATP-dependent DNA helicase (RecQ)
NEB5A_RS19615	COG1280	lysine exporter protein (LysE YggA)
NEB5A_RS19620	COG1280	lysine exporter protein (LysE YggA)
NEB5A_RS19625	COG2267	carboxylic ester hydrolase activity
NEB5A_RS19630	COG0561	phosphatase activity
NEB5A_RS19635	COG0697	spore germination
NEB5A_RS19640	COG0583	DNA-binding transcription factor activity
NEB5A_RS19650	COG0412	Dienelactone hydrolase
NEB5A_RS19655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NEB5A_RS19660	COG1322	Protein conserved in bacteria
NEB5A_RS19670	COG3165	ubiquinone biosynthetic process from chorismate
NEB5A_RS19680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEB5A_RS19685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEB5A_RS19690	COG0805	protein transport
NEB5A_RS19695	COG0084	hydrolase, TatD family'
NEB5A_RS19700	COG0250	Participates in transcription elongation, termination and antitermination
NEB5A_RS19705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NEB5A_RS19710	COG0543	2 iron, 2 sulfur cluster binding
NEB5A_RS19715	COG0183	Belongs to the thiolase family
NEB5A_RS19730	COG1739	Uncharacterized protein family UPF0029
NEB5A_RS19735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NEB5A_RS19740	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NEB5A_RS19770	COG1763	Mo-molybdopterin cofactor biosynthetic process
NEB5A_RS19775	COG0746	molybdenum cofactor guanylyltransferase activity
NEB5A_RS19780	COG3084	Protein conserved in bacteria
NEB5A_RS19785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NEB5A_RS19790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NEB5A_RS19795	COG5339	Protein conserved in bacteria
NEB5A_RS19800	COG0204	Acyl-transferase
NEB5A_RS19815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEB5A_RS19815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEB5A_RS19830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NEB5A_RS19840	COG2204	response regulator
NEB5A_RS19845	COG3852	Histidine kinase
NEB5A_RS19850	COG0174	glutamine synthetase
NEB5A_RS19860	COG1217	gtp-binding protein TYPA
NEB5A_RS19865	COG2188	Transcriptional regulator
NEB5A_RS19870	COG1082	Xylose isomerase domain protein TIM barrel
NEB5A_RS19875	COG2271	Major facilitator Superfamily
NEB5A_RS19880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NEB5A_RS19885	COG2211	Major facilitator Superfamily
NEB5A_RS19890	COG2211	Major facilitator Superfamily
NEB5A_RS19895	COG1501	Belongs to the glycosyl hydrolase 31 family
NEB5A_RS19900	COG2017	converts alpha-aldose to the beta-anomer
NEB5A_RS19905	COG2942	2-epimerase
NEB5A_RS19910	COG3684	Belongs to the aldolase LacD family
NEB5A_RS19915	COG2084	Dehydrogenase
NEB5A_RS19920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NEB5A_RS19925	COG1349	DNA-binding transcription factor activity
NEB5A_RS19930	COG1011	Hydrolase
NEB5A_RS19945	COG0456	acetyltransferase
NEB5A_RS19950	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NEB5A_RS19955	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NEB5A_RS19970	COG2864	formate dehydrogenase
NEB5A_RS19975	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS19980	COG3383	formate dehydrogenase (NAD+) activity
NEB5A_RS19980	COG0243	molybdopterin cofactor binding
NEB5A_RS19985	COG0243	molybdopterin cofactor binding
NEB5A_RS19985	COG3383	formate dehydrogenase (NAD+) activity
NEB5A_RS20000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS20000	COG3711	transcriptional antiterminator
NEB5A_RS20005	COG1363	Peptidase, m42
NEB5A_RS20010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS20010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS20015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS20060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NEB5A_RS20075	COG2258	MOSC domain
NEB5A_RS20080	COG2205	protein histidine kinase activity
NEB5A_RS20085	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS20090	COG3678	ATP-independent chaperone mediated protein folding
NEB5A_RS20105	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NEB5A_RS20125	COG3152	Membrane
NEB5A_RS20130	COG3691	Protein conserved in bacteria
NEB5A_RS20135	COG0589	response to stress
NEB5A_RS20140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEB5A_RS20145	COG1494	fructose-1,6-bisphosphatase
NEB5A_RS20155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NEB5A_RS20170	COG1575	Belongs to the MenA family. Type 1 subfamily
NEB5A_RS20185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NEB5A_RS20190	COG1609	Transcriptional regulator
NEB5A_RS20195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NEB5A_RS20205	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NEB5A_RS20215	COG0626	cystathionine gamma-synthase activity
NEB5A_RS20220	COG0527	aspartate kinase activity
NEB5A_RS20220	COG0460	homoserine dehydrogenase
NEB5A_RS20230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NEB5A_RS20240	COG0697	spore germination
NEB5A_RS20245	COG3738	Protein conserved in bacteria
NEB5A_RS20255	COG0371	Dehydrogenase
NEB5A_RS20260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NEB5A_RS20265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS20265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS20265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NEB5A_RS20270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS20275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS20280	COG1882	Formate acetyltransferase
NEB5A_RS20285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NEB5A_RS20290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NEB5A_RS20295	COG2207	Transcriptional regulator
NEB5A_RS20300	COG2194	sulfuric ester hydrolase activity
NEB5A_RS20320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NEB5A_RS20335	COG0583	DNA-binding transcription factor activity
NEB5A_RS20360	COG4206	TonB-dependent receptor
NEB5A_RS20390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NEB5A_RS20395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NEB5A_RS20395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NEB5A_RS20435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NEB5A_RS20440	COG0250	Participates in transcription elongation, termination and antitermination
NEB5A_RS20480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NEB5A_RS20490	COG2104	thiamine diphosphate biosynthetic process
NEB5A_RS20495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NEB5A_RS20530	COG3068	Protein conserved in bacteria
NEB5A_RS20545	COG3678	ATP-independent chaperone mediated protein folding
NEB5A_RS20550	COG4191	Histidine kinase
NEB5A_RS20555	COG2204	response regulator
NEB5A_RS20560	COG0151	Belongs to the GarS family
NEB5A_RS20605	COG0456	acetyltransferase
NEB5A_RS20615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NEB5A_RS20620	COG2224	Isocitrate lyase
NEB5A_RS20635	COG1414	Transcriptional regulator
NEB5A_RS20640	COG1410	methionine synthase
NEB5A_RS20640	COG0646	methionine synthase
NEB5A_RS20645	COG1283	sodium-dependent phosphate transmembrane transporter activity
NEB5A_RS20655	COG1187	pseudouridine synthase activity
NEB5A_RS20665	COG0527	aspartate kinase activity
NEB5A_RS20690	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NEB5A_RS20710	COG0477	Major facilitator Superfamily
NEB5A_RS20710	COG2814	Major facilitator Superfamily
NEB5A_RS20715	COG3833	ABC-type maltose transport systems, permease component
NEB5A_RS20720	COG1175	transmembrane transport
NEB5A_RS20725	COG2182	Extracellular solute-binding protein
NEB5A_RS20735	COG3842	ATPase activity
NEB5A_RS20755	COG1357	PFAM Pentapeptide repeats (8 copies)
NEB5A_RS20775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NEB5A_RS20785	COG0534	Mate efflux family protein
NEB5A_RS20790	COG3237	CsbD-like
NEB5A_RS20795	COG0735	belongs to the Fur family
NEB5A_RS20810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NEB5A_RS20820	COG0604	alcohol dehydrogenase
NEB5A_RS20825	COG0305	Participates in initiation and elongation during chromosome replication
NEB5A_RS20830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NEB5A_RS20835	COG1448	Aminotransferase
NEB5A_RS20845	COG3700	Belongs to the class B bacterial acid phosphatase family
NEB5A_RS20850	COG0432	Pfam Uncharacterised protein family UPF0047
NEB5A_RS20855	COG2315	Protein conserved in bacteria
NEB5A_RS20860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NEB5A_RS20865	COG0629	single-stranded DNA binding
NEB5A_RS20875	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NEB5A_RS20880	COG2207	Transcriptional regulator
NEB5A_RS20885	COG0789	Transcriptional regulator
NEB5A_RS20890	COG2252	PERMEase
NEB5A_RS20895	COG0025	NhaP-type Na H and K H
NEB5A_RS20900	COG1357	PFAM Pentapeptide repeats (8 copies)
NEB5A_RS20910	COG3162	membrane
NEB5A_RS20915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEB5A_RS20925	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NEB5A_RS20930	COG0437	4 iron, 4 sulfur cluster binding
NEB5A_RS20935	COG3301	Polysulphide reductase, NrfD
NEB5A_RS20940	COG1138	Cytochrome C-type biogenesis protein
NEB5A_RS20945	COG3088	subunit of a heme lyase
NEB5A_RS20950	COG4235	cytochrome complex assembly
NEB5A_RS20955	COG1301	dicarboxylic acid transport
NEB5A_RS20960	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NEB5A_RS20965	COG3383	formate dehydrogenase (NAD+) activity
NEB5A_RS20970	COG3383	formate dehydrogenase (NAD+) activity
NEB5A_RS20975	COG1538	Outer membrane efflux protein
NEB5A_RS20980	COG1289	transmembrane transporter activity
NEB5A_RS20985	COG1566	PFAM secretion protein HlyD family protein
NEB5A_RS20995	COG2015	COG2015, Alkyl sulfatase and related hydrolases
NEB5A_RS21000	COG1940	carbohydrate kinase activity
NEB5A_RS21005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NEB5A_RS21010	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS21015	COG1129	ABC transporter
NEB5A_RS21020	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS21025	COG1737	Transcriptional regulator
NEB5A_RS21030	COG0698	ribose 5-phosphate isomerase
NEB5A_RS21040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NEB5A_RS21045	COG0456	acetyltransferase
NEB5A_RS21050	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NEB5A_RS21055	COG3454	Phosphonate metabolism
NEB5A_RS21060	COG4778	phosphonate C-P lyase system protein PhnL
NEB5A_RS21065	COG4107	phosphonate C-P lyase system protein PhnK
NEB5A_RS21070	COG3627	carbon phosphorus lyase activity
NEB5A_RS21075	COG3626	phosphonate metabolism
NEB5A_RS21080	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
NEB5A_RS21085	COG3624	Phosphonate C-P lyase system protein PhnG
NEB5A_RS21090	COG2188	Transcriptional regulator
NEB5A_RS21100	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NEB5A_RS21105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NEB5A_RS21110	COG2764	glyoxalase bleomycin resistance protein dioxygenase
NEB5A_RS21115	COG2824	Alkylphosphonate utilization operon protein PhnA
NEB5A_RS21120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NEB5A_RS21130	COG0477	Major facilitator Superfamily
NEB5A_RS21140	COG0642	Histidine kinase
NEB5A_RS21145	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS21150	COG2194	sulfuric ester hydrolase activity
NEB5A_RS21155	COG0531	amino acid
NEB5A_RS21160	COG2207	Transcriptional regulator
NEB5A_RS21165	COG1982	Orn Lys Arg decarboxylase major
NEB5A_RS21170	COG2169	Transcriptional regulator
NEB5A_RS21180	COG1486	melibiose metabolic process
NEB5A_RS21185	COG2211	Major facilitator Superfamily
NEB5A_RS21190	COG3647	Membrane
NEB5A_RS21195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NEB5A_RS21195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NEB5A_RS21200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NEB5A_RS21210	COG4565	transcriptional regulatory protein
NEB5A_RS21215	COG3290	protein histidine kinase activity
NEB5A_RS21220	COG3592	Divergent 4Fe-4S mono-cluster
NEB5A_RS21225	COG2388	GCN5-related N-acetyl-transferase
NEB5A_RS21240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NEB5A_RS21245	COG3104	oligopeptide transport
NEB5A_RS21250	COG1982	Orn Lys Arg decarboxylase major
NEB5A_RS21260	COG3710	Transcriptional regulator
NEB5A_RS21270	COG1309	transcriptional regulator
NEB5A_RS21275	COG4232	protein-disulfide reductase activity
NEB5A_RS21285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NEB5A_RS21290	COG1027	Aspartate ammonia-lyase
NEB5A_RS21295	COG3030	protein affecting phage T7 exclusion by the F plasmid
NEB5A_RS21300	COG0531	amino acid
NEB5A_RS21325	COG1509	lysine 2,3-aminomutase activity
NEB5A_RS21335	COG5510	response to toxic substance
NEB5A_RS21340	COG5510	response to toxic substance
NEB5A_RS21345	COG2076	Multidrug Resistance protein
NEB5A_RS21350	COG3040	lipid binding
NEB5A_RS21355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NEB5A_RS21370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NEB5A_RS21375	COG1053	succinate dehydrogenase
NEB5A_RS21385	COG0531	amino acid
NEB5A_RS21400	COG3264	Mechanosensitive ion channel
NEB5A_RS21400	COG1511	domain protein
NEB5A_RS21435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NEB5A_RS21440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NEB5A_RS21440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NEB5A_RS21445	COG0802	atpase or kinase
NEB5A_RS21450	COG0860	N-Acetylmuramoyl-L-alanine amidase
NEB5A_RS21470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NEB5A_RS21475	COG0330	HflC and HflK could
NEB5A_RS21480	COG0330	HflC and HflK could
NEB5A_RS21485	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
NEB5A_RS21500	COG0557	exoribonuclease II activity
NEB5A_RS21505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEB5A_RS21510	COG3789	protein conserved in bacteria
NEB5A_RS21515	COG1842	Phage shock protein A
NEB5A_RS21525	COG3766	membrane
NEB5A_RS21530	COG5463	Belongs to the UPF0441 family
NEB5A_RS21535	COG0754	glutathionylspermidine amidase activity
NEB5A_RS21540	COG1960	acyl-CoA dehydrogenase activity
NEB5A_RS21550	COG3650	response to hydrogen peroxide
NEB5A_RS21555	COG1073	alpha beta
NEB5A_RS21570	COG3037	sugar-specific permease SgaT UlaA
NEB5A_RS21575	COG3414	Phosphotransferase system galactitol-specific IIB component
NEB5A_RS21580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS21620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NEB5A_RS21635	COG1309	transcriptional regulator
NEB5A_RS21640	COG3061	Opacity-associated protein A
NEB5A_RS21645	COG0545	Peptidyl-prolyl cis-trans isomerase
NEB5A_RS21650	COG1113	amino acid transport
NEB5A_RS21660	COG0697	spore germination
NEB5A_RS21665	COG0702	epimerase
NEB5A_RS21670	COG1733	regulation of RNA biosynthetic process
NEB5A_RS21685	COG1218	3'(2'),5'-bisphosphate nucleotidase
NEB5A_RS21695	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
NEB5A_RS21705	COG1253	flavin adenine dinucleotide binding
NEB5A_RS21720	COG0729	surface antigen
NEB5A_RS21725	COG2911	Protein conserved in bacteria
NEB5A_RS21730	COG2105	PFAM AIG2 family protein
NEB5A_RS21735	COG2336	PFAM SpoVT AbrB
NEB5A_RS21740	COG2337	Toxic component of a toxin-antitoxin (TA) module
NEB5A_RS21745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NEB5A_RS21750	COG1879	ABC-type sugar transport system periplasmic component
NEB5A_RS21755	COG1129	ABC transporter
NEB5A_RS21760	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS21765	COG1172	Belongs to the binding-protein-dependent transport system permease family
NEB5A_RS21775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NEB5A_RS21785	COG0312	modulator of DNA gyrase
NEB5A_RS21790	COG3783	Cytochrome b(562)
NEB5A_RS21795	COG0602	queuosine metabolic process
NEB5A_RS21800	COG1328	CTP reductase activity
NEB5A_RS21805	COG0366	Alpha amylase catalytic
NEB5A_RS21810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NEB5A_RS21810	COG1263	PTS System
NEB5A_RS21815	COG1609	Transcriptional regulator
NEB5A_RS21820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NEB5A_RS21825	COG0251	oxidation-reduction process
NEB5A_RS21850	COG0251	oxidation-reduction process
NEB5A_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS21860	COG1309	transcriptional regulator
NEB5A_RS21865	COG2731	YhcH YjgK YiaL family protein
NEB5A_RS21875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NEB5A_RS21880	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NEB5A_RS21885	COG0456	acetyltransferase
NEB5A_RS21890	COG4269	membrane
NEB5A_RS21895	COG0525	valine-tRNA ligase activity
NEB5A_RS21900	COG2927	DNA polymerase III (CHI subunit)
NEB5A_RS21910	COG0795	lipopolysaccharide-transporting ATPase activity
NEB5A_RS21915	COG0795	lipopolysaccharide-transporting ATPase activity
NEB5A_RS21920	COG0433	COG0433 Predicted ATPase
NEB5A_RS21925	COG1609	Transcriptional regulator
NEB5A_RS21930	COG2610	gluconate transmembrane transporter activity
NEB5A_RS21935	COG1028	Short-chain dehydrogenase reductase Sdr
NEB5A_RS21940	COG1063	alcohol dehydrogenase
NEB5A_RS21945	COG3265	gluconokinase activity
NEB5A_RS21950	COG1064	alcohol dehydrogenase
NEB5A_RS21960	COG0582	viral genome integration into host DNA
NEB5A_RS21995	COG3385	transposase activity
NEB5A_RS22000	COG2814	Major facilitator Superfamily
NEB5A_RS22005	COG0673	inositol 2-dehydrogenase activity
NEB5A_RS22025	COG2826	transposase and inactivated derivatives, IS30 family
NEB5A_RS22040	COG2085	NADP oxidoreductase coenzyme F420-dependent
NEB5A_RS22045	COG1120	ATPase activity
NEB5A_RS22050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEB5A_RS22055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEB5A_RS22060	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NEB5A_RS22065	COG4772	TonB-dependent receptor
NEB5A_RS22070	COG3712	iron ion homeostasis
NEB5A_RS22075	COG1595	DNA-templated transcription, initiation
NEB5A_RS22095	COG2390	Transcriptional regulator
NEB5A_RS22105	COG2610	gluconate transmembrane transporter activity
NEB5A_RS22110	COG0129	dihydroxy-acid dehydratase activity
NEB5A_RS22115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NEB5A_RS22120	COG1414	Transcriptional regulator
NEB5A_RS22125	COG1349	DNA-binding transcription factor activity
NEB5A_RS22130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NEB5A_RS22135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NEB5A_RS22140	COG0434	BtpA family
NEB5A_RS22145	COG3775	system Galactitol-specific IIC component
NEB5A_RS22150	COG3414	Phosphotransferase system galactitol-specific IIB component
NEB5A_RS22155	COG1363	Peptidase, m42
NEB5A_RS22160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NEB5A_RS22165	COG3153	acetyltransferase
NEB5A_RS22185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NEB5A_RS22185	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NEB5A_RS22195	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
NEB5A_RS22200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NEB5A_RS22215	COG0582	viral genome integration into host DNA
NEB5A_RS22225	COG4974	Belongs to the 'phage' integrase family
NEB5A_RS22235	COG3539	Fimbrial protein
NEB5A_RS22240	COG3539	Fimbrial protein
NEB5A_RS22245	COG3121	Chaperone
NEB5A_RS22250	COG3188	usher protein
NEB5A_RS22255	COG3539	Fimbrial protein
NEB5A_RS22260	COG3539	Fimbrial protein
NEB5A_RS22265	COG3539	Fimbrial protein
NEB5A_RS22270	COG2610	gluconate transmembrane transporter activity
NEB5A_RS22285	COG0246	Mannitol dehydrogenase
NEB5A_RS22295	COG2186	Transcriptional regulator
NEB5A_RS22320	COG0583	DNA-binding transcription factor activity
NEB5A_RS22325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NEB5A_RS22330	COG0700	Nucleoside recognition
NEB5A_RS22335	COG3366	ferrous iron transmembrane transporter activity
NEB5A_RS22345	COG0477	Major facilitator Superfamily
NEB5A_RS22350	COG3204	pilus organization
NEB5A_RS22360	COG1924	4 iron, 4 sulfur cluster binding
NEB5A_RS22365	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NEB5A_RS22370	COG2733	membrane
NEB5A_RS22375	COG2814	Major facilitator Superfamily
NEB5A_RS22385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEB5A_RS22390	COG5457	Domain of unknown function (DUF1127)
NEB5A_RS22395	COG1196	nuclear chromosome segregation
NEB5A_RS22405	COG4268	DNA restriction-modification system
NEB5A_RS22410	COG1401	restriction endodeoxyribonuclease activity
NEB5A_RS22420	COG0732	type I restriction modification DNA specificity domain
NEB5A_RS22425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NEB5A_RS22435	COG1715	Restriction endonuclease
NEB5A_RS22440	COG0523	cobalamin synthesis protein
NEB5A_RS22445	COG2879	small protein
NEB5A_RS22450	COG1966	Carbon starvation protein
NEB5A_RS22460	COG0840	transmembrane signaling receptor activity
NEB5A_RS22465	COG2271	Major facilitator Superfamily
NEB5A_RS22470	COG1802	Transcriptional regulator
NEB5A_RS22475	COG1063	alcohol dehydrogenase
NEB5A_RS22490	COG1484	DNA-dependent DNA replication
NEB5A_RS22505	COG2966	Psort location CytoplasmicMembrane, score
NEB5A_RS22510	COG2197	response regulator
NEB5A_RS22515	COG2197	response regulator
NEB5A_RS22520	COG4114	ferric iron reductase
NEB5A_RS22550	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
NEB5A_RS22555	COG0456	acetyltransferase
NEB5A_RS22560	COG1011	Hydrolase
NEB5A_RS22570	COG2823	Periplasmic or secreted lipoprotein
NEB5A_RS22580	COG4667	esterase of the alpha-beta hydrolase superfamily
NEB5A_RS22585	COG0084	hydrolase, TatD family'
NEB5A_RS22590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NEB5A_RS22595	COG1328	CTP reductase activity
NEB5A_RS22625	COG3550	peptidyl-serine autophosphorylation
NEB5A_RS22635	COG3726	membrane protein affecting hemolysin expression
NEB5A_RS22640	COG0560	Phosphoserine phosphatase
NEB5A_RS22645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NEB5A_RS22650	COG3172	ATPase kinase involved in NAD metabolism
NEB5A_RS22650	COG1056	cytidyltransferase-related domain
NEB5A_RS22660	COG0488	(ABC) transporter
NEB5A_RS22665	COG0741	lytic transglycosylase activity
NEB5A_RS22685	COG3708	Transcriptional regulator
NEB5A_RS22685	COG2207	Transcriptional regulator
NEB5A_RS22690	COG3045	CreA protein
NEB5A_RS22695	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS22700	COG2205	protein histidine kinase activity
NEB5A_RS22705	COG4452	Inner membrane protein CreD
NEB5A_RS22710	COG0745	RESPONSE REGULATOR receiver
NEB5A_RS22720	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA