locus-tag	class	description
HT750_RS00045	COG4695	Portal protein
HT750_RS00135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HT750_RS00150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT750_RS00195	COG1882	Formate acetyltransferase
HT750_RS00200	COG2116	formate transmembrane transporter activity
HT750_RS00205	COG1944	ATP diphosphatase activity
HT750_RS00210	COG2323	membrane
HT750_RS00225	COG0501	Belongs to the peptidase M48B family
HT750_RS00235	COG0539	negative regulation of cytoplasmic translation
HT750_RS00245	COG0658	competence protein
HT750_RS00245	COG2333	competence protein COMEC
HT750_RS00250	COG1132	(ABC) transporter
HT750_RS00260	COG3214	Protein conserved in bacteria
HT750_RS00275	COG3173	Aminoglycoside phosphotransferase
HT750_RS00280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HT750_RS00285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HT750_RS00295	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HT750_RS00305	COG2989	Protein conserved in bacteria
HT750_RS00310	COG3108	Peptidase M15
HT750_RS00315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT750_RS00320	COG1448	Aminotransferase
HT750_RS00325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HT750_RS00340	COG0308	aminopeptidase N
HT750_RS00345	COG1116	anion transmembrane transporter activity
HT750_RS00350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HT750_RS00360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HT750_RS00365	COG0431	NADPH-dependent FMN reductase
HT750_RS00370	COG3539	Fimbrial protein
HT750_RS00375	COG3121	Chaperone
HT750_RS00380	COG3188	usher protein
HT750_RS00385	COG3539	Fimbrial protein
HT750_RS00390	COG3539	Fimbrial protein
HT750_RS00395	COG3539	Fimbrial protein
HT750_RS00400	COG3121	Chaperone
HT750_RS00415	COG0633	Ferredoxin
HT750_RS00415	COG3217	Mosc domain protein beta barrel domain protein
HT750_RS00425	COG0488	(ABC) transporter
HT750_RS00430	COG2995	paraquat-inducible protein a
HT750_RS00435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HT750_RS00435	COG3008	intermembrane lipid transfer
HT750_RS00440	COG3009	Protein conserved in bacteria
HT750_RS00445	COG3130	regulation of translation
HT750_RS00455	COG1067	ATP-dependent peptidase activity
HT750_RS00475	COG3070	regulator of competence-specific genes
HT750_RS00480	COG1289	transmembrane transporter activity
HT750_RS00485	COG3304	Inner membrane component domain
HT750_RS00490	COG0210	DNA helicase
HT750_RS00505	COG1832	CoA-binding protein
HT750_RS00520	COG1254	Belongs to the acylphosphatase family
HT750_RS00525	COG2920	part of a sulfur-relay system
HT750_RS00530	COG0670	Belongs to the BI1 family
HT750_RS00540	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HT750_RS00545	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HT750_RS00550	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HT750_RS00555	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HT750_RS00560	COG1999	signal sequence binding
HT750_RS00565	COG1773	rubredoxin
HT750_RS00570	COG1271	oxidase subunit
HT750_RS00575	COG1294	oxidase, subunit
HT750_RS00590	COG1278	Cold shock
HT750_RS00595	COG1278	Cold shock
HT750_RS00615	COG0348	domain, Protein
HT750_RS00620	COG2198	Histidine kinase
HT750_RS00620	COG0784	Response regulator, receiver
HT750_RS00620	COG2205	protein histidine kinase activity
HT750_RS00625	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS00630	COG0745	RESPONSE REGULATOR receiver
HT750_RS00635	COG3005	denitrification pathway
HT750_RS00640	COG0243	molybdopterin cofactor binding
HT750_RS00680	COG3729	General stress protein
HT750_RS00685	COG2233	PERMEase
HT750_RS00710	COG1335	isochorismatase
HT750_RS00720	COG1309	transcriptional regulator
HT750_RS00725	COG0506	proline dehydrogenase activity
HT750_RS00725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HT750_RS00725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HT750_RS00735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT750_RS00755	COG1702	phosphate starvation-inducible protein PhoH
HT750_RS00760	COG3658	cytochrome
HT750_RS00765	COG1215	transferase activity, transferring glycosyl groups
HT750_RS00770	COG1649	PFAM Uncharacterised BCR, COG1649
HT750_RS00770	COG0726	polysaccharide deacetylase
HT750_RS00775	COG0457	Tetratricopeptide repeat
HT750_RS00780	COG3706	GGDEF domain
HT750_RS00800	COG3381	protein complex oligomerization
HT750_RS00810	COG1462	curli production assembly transport component CsgG
HT750_RS00825	COG2197	response regulator
HT750_RS00850	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HT750_RS00855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT750_RS00870	COG2943	transferase activity, transferring hexosyl groups
HT750_RS00875	COG5645	(Lipo)protein
HT750_RS00890	COG1560	Kdo2-lipid A biosynthetic process
HT750_RS00900	COG2353	YceI-like domain
HT750_RS00905	COG3038	cytochrome b561
HT750_RS00915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT750_RS00940	COG2999	glutathione oxidoreductase activity
HT750_RS00950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT750_RS00960	COG0673	inositol 2-dehydrogenase activity
HT750_RS00965	COG0728	peptidoglycan biosynthetic process
HT750_RS00970	COG3418	PFAM FlgN family protein
HT750_RS00975	COG2747	anti-sigma28 factor FlgM
HT750_RS00980	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HT750_RS00985	COG1815	bacterial-type flagellum-dependent cell motility
HT750_RS00990	COG1558	bacterial-type flagellum-dependent cell motility
HT750_RS00995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HT750_RS01000	COG1749	Flagellar hook protein flgE
HT750_RS01005	COG4787	bacterial-type flagellum-dependent cell motility
HT750_RS01010	COG4786	Flagellar basal body rod
HT750_RS01025	COG3951	Flagellar rod assembly protein muramidase FlgJ
HT750_RS01025	COG1705	Flagellar rod assembly protein muramidase FlgJ
HT750_RS01030	COG1256	bacterial-type flagellum assembly
HT750_RS01035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HT750_RS01050	COG1530	ribonuclease E activity
HT750_RS01055	COG0564	pseudouridine synthase activity
HT750_RS01060	COG0424	maF-like protein
HT750_RS01065	COG1399	metal-binding, possibly nucleic acid-binding protein
HT750_RS01085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT750_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS01100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT750_RS01105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT750_RS01110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HT750_RS01120	COG0470	DNA polymerase III
HT750_RS01125	COG0084	hydrolase, TatD family'
HT750_RS01130	COG1263	PTS System
HT750_RS01130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS01135	COG4773	Receptor
HT750_RS01140	COG0537	adenosine 5'-monophosphoramidase activity
HT750_RS01145	COG5633	Lipoprotein
HT750_RS01150	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HT750_RS01170	COG1252	NADH dehydrogenase
HT750_RS01175	COG3134	Outer membrane lipoprotein
HT750_RS01180	COG1309	transcriptional regulator
HT750_RS01190	COG1376	ErfK ybiS ycfS ynhG family protein
HT750_RS01190	COG1388	LysM domain
HT750_RS01195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HT750_RS01200	COG4763	Acyl-transferase
HT750_RS01205	COG4591	ABC-type transport system involved in lipoprotein release permease component
HT750_RS01215	COG4591	ABC-type transport system involved in lipoprotein release permease component
HT750_RS01225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HT750_RS01230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HT750_RS01240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HT750_RS01245	COG1177	transmembrane transport
HT750_RS01255	COG3842	ATPase activity
HT750_RS01265	COG2850	peptidyl-arginine hydroxylation
HT750_RS01270	COG2205	protein histidine kinase activity
HT750_RS01280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HT750_RS01300	COG1187	pseudouridine synthase activity
HT750_RS01305	COG0538	isocitrate dehydrogenase activity
HT750_RS01320	COG5562	phage envelope protein
HT750_RS01325	COG0789	Transcriptional regulator
HT750_RS01330	COG2200	EAL domain
HT750_RS01355	COG2200	EAL domain
HT750_RS01410	COG2894	cell division
HT750_RS01435	COG0179	Fumarylacetoacetate (FAA) hydrolase
HT750_RS01450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HT750_RS01455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT750_RS01460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HT750_RS01475	COG2719	SpoVR family
HT750_RS01485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HT750_RS01505	COG1619	proteins homologs of microcin C7 resistance protein MccF
HT750_RS01515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HT750_RS01530	COG0157	Belongs to the NadC ModD family
HT750_RS01535	COG0500	methyltransferase
HT750_RS01540	COG1120	ATPase activity
HT750_RS01565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS01565	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HT750_RS01565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HT750_RS01570	COG1461	Dihydroxyacetone kinase
HT750_RS01575	COG2376	Dihydroxyacetone kinase
HT750_RS01580	COG3284	Transcriptional regulator
HT750_RS01590	COG0012	GTP binding
HT750_RS01605	COG0659	secondary active sulfate transmembrane transporter activity
HT750_RS01610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HT750_RS01635	COG2890	protein-(glutamine-N5) methyltransferase activity
HT750_RS01640	COG3094	Invasion gene expression up-regulator, SirB
HT750_RS01645	COG2912	Transglutaminase-like superfamily
HT750_RS01670	COG0387	Pfam Sodium calcium exchanger
HT750_RS01675	COG4572	Cation transport regulator
HT750_RS01680	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HT750_RS01685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HT750_RS01690	COG4932	domain protein
HT750_RS01695	COG2197	response regulator
HT750_RS01700	COG3850	Histidine kinase
HT750_RS01705	COG2223	nitrite transmembrane transporter activity
HT750_RS01710	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HT750_RS01715	COG1140	nitrate reductase beta subunit
HT750_RS01720	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HT750_RS01725	COG2181	nitrate reductase activity
HT750_RS01750	COG0788	formyltetrahydrofolate deformylase activity
HT750_RS01760	COG1752	Esterase of the alpha-beta hydrolase superfamily
HT750_RS01765	COG0745	RESPONSE REGULATOR receiver
HT750_RS01770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HT750_RS01780	COG1435	thymidine kinase activity
HT750_RS01785	COG3385	transposase activity
HT750_RS01790	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS01790	COG1454	alcohol dehydrogenase
HT750_RS01795	COG2095	MarC family integral membrane protein
HT750_RS01805	COG4166	transmembrane transport
HT750_RS01810	COG0601	transmembrane transport
HT750_RS01815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT750_RS01820	COG0444	Belongs to the ABC transporter superfamily
HT750_RS01825	COG4608	Belongs to the ABC transporter superfamily
HT750_RS01845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HT750_RS01850	COG2350	Protein conserved in bacteria
HT750_RS01860	COG1607	acyl-coa hydrolase
HT750_RS01880	COG3047	cAMP biosynthetic process
HT750_RS01885	COG3685	Protein conserved in bacteria
HT750_RS01890	COG3685	Protein conserved in bacteria
HT750_RS01895	COG3729	General stress protein
HT750_RS01910	COG0135	phosphoribosylanthranilate isomerase activity
HT750_RS01910	COG0134	indole-3-glycerol-phosphate synthase activity
HT750_RS01915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HT750_RS01915	COG0512	Glutamine amidotransferase of anthranilate synthase
HT750_RS01920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HT750_RS01930	COG0613	PHP domain protein
HT750_RS01935	COG0009	L-threonylcarbamoyladenylate synthase
HT750_RS01940	COG4907	membrane protein (DUF2207)
HT750_RS01945	COG1187	pseudouridine synthase activity
HT750_RS01960	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HT750_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS01970	COG0616	signal peptide processing
HT750_RS01980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HT750_RS01985	COG0583	DNA-binding transcription factor activity
HT750_RS02005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HT750_RS02015	COG0671	phosphoesterase, PA-phosphatase related
HT750_RS02020	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HT750_RS02025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HT750_RS02035	COG0023	Translation Initiation Factor
HT750_RS02045	COG1349	DNA-binding transcription factor activity
HT750_RS02055	COG5001	Diguanylate cyclase
HT750_RS02070	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT750_RS02070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT750_RS02075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HT750_RS02085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS02090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT750_RS02100	COG2814	Major facilitator Superfamily
HT750_RS02105	COG4172	Belongs to the ABC transporter superfamily
HT750_RS02110	COG4172	Belongs to the ABC transporter superfamily
HT750_RS02115	COG4171	peptide transport system, permease
HT750_RS02120	COG4168	peptide transport system, permease
HT750_RS02125	COG4166	transmembrane transport
HT750_RS02135	COG0531	amino acid
HT750_RS02145	COG0174	glutamine synthetase
HT750_RS02150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HT750_RS02155	COG1396	sequence-specific DNA binding
HT750_RS02155	COG1917	Cupin 2, conserved barrel domain protein
HT750_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS02165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT750_RS02170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HT750_RS02175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HT750_RS02180	COG1842	Phage shock protein A
HT750_RS02190	COG1983	PspC domain protein
HT750_RS02200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT750_RS02205	COG0366	Alpha amylase catalytic
HT750_RS02210	COG1653	transport
HT750_RS02215	COG1175	transmembrane transport
HT750_RS02220	COG0395	ABC-type sugar transport system, permease component
HT750_RS02225	COG1063	alcohol dehydrogenase
HT750_RS02230	COG1082	Xylose isomerase domain protein TIM barrel
HT750_RS02235	COG0673	inositol 2-dehydrogenase activity
HT750_RS02240	COG1554	hydrolase, family 65, central catalytic
HT750_RS02245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT750_RS02250	COG3842	ATPase activity
HT750_RS02260	COG1609	Transcriptional regulator
HT750_RS02265	COG3106	COG3106 Predicted ATPase
HT750_RS02275	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HT750_RS02280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HT750_RS02285	COG4948	Mandelate Racemase Muconate Lactonizing
HT750_RS02290	COG2866	Carboxypeptidase
HT750_RS02295	COG4166	transmembrane transport
HT750_RS02300	COG0668	transmembrane transport
HT750_RS02305	COG3182	Iron-regulated membrane protein
HT750_RS02310	COG0589	response to stress
HT750_RS02315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT750_RS02320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HT750_RS02325	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HT750_RS02330	COG1473	amidohydrolase
HT750_RS02335	COG1473	amidohydrolase
HT750_RS02340	COG0583	DNA-binding transcription factor activity
HT750_RS02345	COG2840	Smr protein MutS2
HT750_RS02350	COG3706	GGDEF domain
HT750_RS02360	COG0513	Belongs to the DEAD box helicase family
HT750_RS02370	COG0589	response to stress
HT750_RS02375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HT750_RS02380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HT750_RS02380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HT750_RS02380	COG1013	pyruvate-flavodoxin oxidoreductase activity
HT750_RS02380	COG0674	pyruvate-flavodoxin oxidoreductase activity
HT750_RS02385	COG3042	response to heat
HT750_RS02390	COG3187	Heat shock protein
HT750_RS02395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HT750_RS02400	COG2911	Protein conserved in bacteria
HT750_RS02410	COG3784	Protein of unknown function (DUF1318)
HT750_RS02415	COG2207	Transcriptional regulator
HT750_RS02420	COG3327	negative regulation of DNA-templated transcription, initiation
HT750_RS02425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HT750_RS02430	COG0667	Aldo Keto reductase
HT750_RS02440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HT750_RS02445	COG4589	Belongs to the CDS family
HT750_RS02450	COG2267	carboxylic ester hydrolase activity
HT750_RS02455	COG0671	phosphoesterase, PA-phosphatase related
HT750_RS02455	COG2453	phosphatase
HT750_RS02465	COG1643	Atp-dependent helicase
HT750_RS02470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HT750_RS02475	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS02480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HT750_RS02485	COG3038	cytochrome b561
HT750_RS02505	COG0840	transmembrane signaling receptor activity
HT750_RS02510	COG0583	DNA-binding transcription factor activity
HT750_RS02515	COG5383	Protein conserved in bacteria
HT750_RS02525	COG2841	Protein conserved in bacteria
HT750_RS02530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT750_RS02535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HT750_RS02540	COG1275	C4-dicarboxylate transporter malic acid transport protein
HT750_RS02545	COG0500	methyltransferase
HT750_RS02560	COG0675	Transposase, IS605 OrfB family
HT750_RS02565	COG3135	benzoate transporter
HT750_RS02570	COG1396	sequence-specific DNA binding
HT750_RS02575	COG0826	peptidase U32
HT750_RS02590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT750_RS02595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HT750_RS02600	COG3842	ATPase activity
HT750_RS02605	COG1176	ABC-type spermidine putrescine transport system, permease component I
HT750_RS02610	COG1177	transmembrane transport
HT750_RS02635	COG3238	Protein conserved in bacteria
HT750_RS02640	COG1247	-acetyltransferase
HT750_RS02645	COG2130	NADP-dependent
HT750_RS02650	COG1802	Transcriptional regulator
HT750_RS02655	COG4772	TonB-dependent receptor
HT750_RS02665	COG1113	amino acid transport
HT750_RS02670	COG0625	glutathione transferase activity
HT750_RS02675	COG2203	Gaf domain
HT750_RS02675	COG5001	Diguanylate cyclase
HT750_RS02675	COG3706	GGDEF domain
HT750_RS02675	COG4251	negative regulation of phosphorylation
HT750_RS02680	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HT750_RS02690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HT750_RS02695	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HT750_RS02705	COG0384	phenazine biosynthesis protein PhzF
HT750_RS02710	COG2181	nitrate reductase activity
HT750_RS02715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HT750_RS02720	COG1140	nitrate reductase beta subunit
HT750_RS02725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HT750_RS02730	COG2223	nitrite transmembrane transporter activity
HT750_RS02735	COG4886	Leucine-rich repeat (LRR) protein
HT750_RS02740	COG4886	Leucine-rich repeat (LRR) protein
HT750_RS02750	COG0697	spore germination
HT750_RS02760	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS02765	COG2864	formate dehydrogenase
HT750_RS02770	COG3093	addiction module antidote protein HigA
HT750_RS02780	COG1064	alcohol dehydrogenase
HT750_RS02800	COG1764	response to oxidative stress
HT750_RS02805	COG4608	Belongs to the ABC transporter superfamily
HT750_RS02810	COG0444	Belongs to the ABC transporter superfamily
HT750_RS02815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT750_RS02820	COG0601	transmembrane transport
HT750_RS02825	COG0747	negative chemotaxis
HT750_RS02830	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HT750_RS02835	COG2202	Pas domain
HT750_RS02835	COG2200	EAL domain
HT750_RS02835	COG2199	diguanylate cyclase activity
HT750_RS02850	COG0531	amino acid
HT750_RS02855	COG0076	glutamate decarboxylase activity
HT750_RS02860	COG0612	Peptidase, M16
HT750_RS02865	COG4771	TonB-dependent receptor
HT750_RS02870	COG4178	(ABC) transporter
HT750_RS02880	COG0641	radical SAM
HT750_RS02885	COG3119	arylsulfatase activity
HT750_RS02900	COG0243	molybdopterin cofactor binding
HT750_RS02905	COG3539	Fimbrial protein
HT750_RS02910	COG3539	Fimbrial protein
HT750_RS02925	COG3539	Fimbrial protein
HT750_RS02930	COG3188	usher protein
HT750_RS02935	COG3121	Chaperone
HT750_RS02940	COG3539	Fimbrial protein
HT750_RS03005	COG3781	membrane
HT750_RS03015	COG2199	diguanylate cyclase activity
HT750_RS03025	COG2066	Belongs to the glutaminase family
HT750_RS03030	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS03035	COG0583	DNA-binding transcription factor activity
HT750_RS03055	COG1846	Transcriptional regulator
HT750_RS03060	COG4977	sequence-specific DNA binding
HT750_RS03070	COG2723	6-phospho-beta-galactosidase activity
HT750_RS03080	COG1447	Phosphotransferase system cellobiose-specific component IIA
HT750_RS03095	COG2188	Transcriptional regulator
HT750_RS03100	COG0697	spore germination
HT750_RS03105	COG2814	Major facilitator Superfamily
HT750_RS03125	COG3706	GGDEF domain
HT750_RS03130	COG3111	PFAM Bacterial OB fold (BOF) protein
HT750_RS03135	COG0339	signal peptide processing
HT750_RS03140	COG4221	oxidoreductase activity
HT750_RS03145	COG1802	Transcriptional regulator
HT750_RS03155	COG0246	Mannitol dehydrogenase
HT750_RS03160	COG0477	Major facilitator Superfamily
HT750_RS03165	COG1063	alcohol dehydrogenase
HT750_RS03170	COG4948	Mandelate Racemase Muconate Lactonizing
HT750_RS03185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT750_RS03200	COG0243	molybdopterin cofactor binding
HT750_RS03205	COG0243	molybdopterin cofactor binding
HT750_RS03210	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS03215	COG3302	dmso reductase anchor subunit
HT750_RS03220	COG3381	protein complex oligomerization
HT750_RS03230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HT750_RS03235	COG1940	carbohydrate kinase activity
HT750_RS03240	COG0583	DNA-binding transcription factor activity
HT750_RS03245	COG2814	Major facilitator Superfamily
HT750_RS03260	COG3591	Belongs to the peptidase S1B family
HT750_RS03275	COG0628	permease
HT750_RS03280	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HT750_RS03285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HT750_RS03295	COG0531	amino acid
HT750_RS03305	COG3136	membrane protein required for alginate biosynthesis
HT750_RS03310	COG0745	RESPONSE REGULATOR receiver
HT750_RS03315	COG2205	protein histidine kinase activity
HT750_RS03325	COG0114	fumarate hydratase activity
HT750_RS03330	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS03330	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS03335	COG1482	cell wall glycoprotein biosynthetic process
HT750_RS03340	COG5339	Protein conserved in bacteria
HT750_RS03355	COG3250	beta-galactosidase activity
HT750_RS03360	COG1309	transcriptional regulator
HT750_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS03370	COG1609	Transcriptional regulator
HT750_RS03375	COG1263	PTS System
HT750_RS03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS03380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HT750_RS03390	COG0673	inositol 2-dehydrogenase activity
HT750_RS03430	COG4659	FMN binding
HT750_RS03440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HT750_RS03445	COG3104	oligopeptide transport
HT750_RS03450	COG0625	glutathione transferase activity
HT750_RS03455	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HT750_RS03470	COG3895	Periplasmic Protein
HT750_RS03480	COG3133	Outer membrane lipoprotein
HT750_RS03495	COG1566	PFAM secretion protein HlyD family protein
HT750_RS03500	COG1289	transmembrane transporter activity
HT750_RS03505	COG2032	superoxide dismutase activity
HT750_RS03510	COG4989	oxidoreductase activity
HT750_RS03515	COG3313	Fe-S protein
HT750_RS03520	COG1309	transcriptional regulator
HT750_RS03525	COG1902	pentaerythritol trinitrate reductase activity
HT750_RS03530	COG0346	lactoylglutathione lyase activity
HT750_RS03540	COG1201	RNA secondary structure unwinding
HT750_RS03545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HT750_RS03550	COG0791	NLP P60 protein
HT750_RS03555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HT750_RS03560	COG2814	Major facilitator Superfamily
HT750_RS03575	COG0583	DNA-binding transcription factor activity
HT750_RS03580	COG2814	Major facilitator Superfamily
HT750_RS03585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HT750_RS03590	COG0307	riboflavin synthase, alpha
HT750_RS03600	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS03620	COG4529	Protein conserved in bacteria
HT750_RS03630	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HT750_RS03635	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS03645	COG2414	aldehyde ferredoxin oxidoreductase
HT750_RS03650	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS03660	COG0469	pyruvate kinase activity
HT750_RS03665	COG4238	major outer membrane lipoprotein
HT750_RS03670	COG1376	ErfK ybiS ycfS ynhG family protein
HT750_RS03685	COG0719	Fe-S assembly protein
HT750_RS03690	COG0396	ATPase activity
HT750_RS03695	COG0719	Fe-S assembly protein
HT750_RS03700	COG0316	Belongs to the HesB IscA family
HT750_RS03710	COG2050	protein possibly involved in aromatic compounds catabolism
HT750_RS03715	COG0277	FAD linked oxidase domain protein
HT750_RS03715	COG0247	lactate metabolic process
HT750_RS03720	COG0628	permease
HT750_RS03735	COG0738	Major facilitator superfamily
HT750_RS03740	COG2271	Major facilitator Superfamily
HT750_RS03755	COG4670	ketone body catabolic process
HT750_RS03760	COG1960	acyl-CoA dehydrogenase activity
HT750_RS03765	COG1917	Cupin 2, conserved barrel domain protein
HT750_RS03765	COG2207	Transcriptional regulator
HT750_RS03770	COG2086	electron transfer activity
HT750_RS03775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HT750_RS03780	COG0644	oxidoreductase
HT750_RS03785	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HT750_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
HT750_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS03805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HT750_RS03810	COG0471	metal ion transport
HT750_RS03815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HT750_RS03815	COG0574	Belongs to the PEP-utilizing enzyme family
HT750_RS03825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HT750_RS03830	COG4256	Hemin uptake protein
HT750_RS03840	COG2200	EAL domain
HT750_RS03845	COG0791	NLP P60 protein
HT750_RS03855	COG0386	Belongs to the glutathione peroxidase family
HT750_RS03915	COG3137	Salt-induced outer membrane protein
HT750_RS03920	COG1105	Belongs to the carbohydrate kinase PfkB family
HT750_RS03930	COG3001	Fructosamine kinase
HT750_RS03940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT750_RS03945	COG1988	membrane-bound metal-dependent
HT750_RS03965	COG0753	catalase activity
HT750_RS03970	COG3394	polysaccharide catabolic process
HT750_RS03975	COG1486	melibiose metabolic process
HT750_RS03980	COG2169	Transcriptional regulator
HT750_RS03980	COG1917	Cupin 2, conserved barrel domain protein
HT750_RS03985	COG1447	Phosphotransferase system cellobiose-specific component IIA
HT750_RS03990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT750_RS03995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT750_RS04000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HT750_RS04010	COG0322	excinuclease ABC activity
HT750_RS04020	COG3678	ATP-independent chaperone mediated protein folding
HT750_RS04050	COG0708	Exodeoxyribonuclease III
HT750_RS04055	COG0398	Pfam SNARE associated Golgi protein
HT750_RS04065	COG0398	Pfam SNARE associated Golgi protein
HT750_RS04070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT750_RS04075	COG4134	Bacterial extracellular solute-binding protein
HT750_RS04080	COG4135	transport system, permease component
HT750_RS04085	COG4136	ATPase activity
HT750_RS04090	COG2897	thiosulfate sulfurtransferase activity
HT750_RS04095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HT750_RS04100	COG0494	nUDIX hydrolase
HT750_RS04110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT750_RS04115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HT750_RS04120	COG0709	Synthesizes selenophosphate from selenide and ATP
HT750_RS04125	COG0778	Nitroreductase
HT750_RS04130	COG0616	signal peptide processing
HT750_RS04135	COG0252	asparaginase activity
HT750_RS04140	COG1335	isochorismatase
HT750_RS04145	COG2814	Major facilitator Superfamily
HT750_RS04150	COG1349	DNA-binding transcription factor activity
HT750_RS04155	COG0667	Aldo Keto reductase
HT750_RS04160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS04165	COG0191	fructose-bisphosphate aldolase activity
HT750_RS04170	COG1063	alcohol dehydrogenase
HT750_RS04175	COG2271	Major facilitator Superfamily
HT750_RS04180	COG1063	alcohol dehydrogenase
HT750_RS04185	COG3139	Protein of unknown function (DUF1315)
HT750_RS04195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HT750_RS04200	COG0676	glucose-6-phosphate 1-epimerase activity
HT750_RS04205	COG0656	L-ascorbic acid biosynthetic process
HT750_RS04210	COG3713	MltA-interacting MipA family protein
HT750_RS04215	COG2766	serine protein kinase
HT750_RS04225	COG2199	diguanylate cyclase activity
HT750_RS04230	COG2199	diguanylate cyclase activity
HT750_RS04235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HT750_RS04250	COG2207	Transcriptional regulator
HT750_RS04255	COG2807	transmembrane transport
HT750_RS04260	COG3189	MarR family transcriptional regulator
HT750_RS04265	COG3042	response to heat
HT750_RS04270	COG2203	Gaf domain
HT750_RS04270	COG2199	diguanylate cyclase activity
HT750_RS04285	COG2261	transglycosylase associated protein
HT750_RS04295	COG3615	Tellurite resistance protein tehB
HT750_RS04305	COG0583	DNA-binding transcription factor activity
HT750_RS04310	COG0473	3-isopropylmalate dehydrogenase activity
HT750_RS04315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HT750_RS04320	COG4638	Rieske (2fe-2S)
HT750_RS04325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HT750_RS04330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HT750_RS04335	COG0318	PFAM AMP-dependent synthetase and ligase
HT750_RS04340	COG3065	identical protein binding
HT750_RS04345	COG1214	PFAM Peptidase M22, glycoprotease
HT750_RS04350	COG1199	ATP-dependent helicase activity
HT750_RS04355	COG0251	oxidation-reduction process
HT750_RS04370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HT750_RS04375	COG0494	nUDIX hydrolase
HT750_RS04380	COG1760	l-serine dehydratase
HT750_RS04385	COG2200	EAL domain
HT750_RS04390	COG1253	flavin adenine dinucleotide binding
HT750_RS04395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS04395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS04400	COG3715	PTS system
HT750_RS04405	COG3716	PTS system mannose fructose sorbose family IID component
HT750_RS04420	COG2226	methyltransferase
HT750_RS04450	COG1414	Transcriptional regulator
HT750_RS04455	COG2814	Major facilitator Superfamily
HT750_RS04465	COG0793	Belongs to the peptidase S41A family
HT750_RS04475	COG1956	GAF domain-containing protein
HT750_RS04480	COG2995	paraquat-inducible protein a
HT750_RS04485	COG3008	intermembrane lipid transfer
HT750_RS04505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HT750_RS04510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT750_RS04520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HT750_RS04650	COG1783	phage Terminase large subunit
HT750_RS04655	COG5484	DNA packaging
HT750_RS04655	COG3728	DNA packaging
HT750_RS04740	COG1846	Transcriptional regulator
HT750_RS04745	COG1484	DNA-dependent DNA replication
HT750_RS04750	COG3756	Protein conserved in bacteria
HT750_RS04790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HT750_RS04815	COG0582	viral genome integration into host DNA
HT750_RS04825	COG1276	copper resistance
HT750_RS04830	COG2372	response to copper ion
HT750_RS04840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT750_RS04845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HT750_RS04850	COG1770	oligopeptidase
HT750_RS04855	COG2979	Protein of unknown function (DUF533)
HT750_RS04865	COG3141	response to X-ray
HT750_RS04875	COG0800	Aldolase
HT750_RS04880	COG0129	dihydroxy-acid dehydratase activity
HT750_RS04885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HT750_RS04890	COG1737	Transcriptional regulator
HT750_RS04895	COG0469	pyruvate kinase activity
HT750_RS04900	COG1560	Kdo2-lipid A biosynthetic process
HT750_RS04905	COG0739	heme binding
HT750_RS04910	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HT750_RS04920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT750_RS04955	COG0217	transcriptional regulatory protein
HT750_RS04960	COG0494	nUDIX hydrolase
HT750_RS04970	COG1335	isochorismatase
HT750_RS04975	COG1801	Protein of unknown function DUF72
HT750_RS04980	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HT750_RS04995	COG0243	molybdopterin cofactor binding
HT750_RS05000	COG3005	denitrification pathway
HT750_RS05010	COG3102	Protein conserved in bacteria
HT750_RS05025	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HT750_RS05030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HT750_RS05035	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HT750_RS05040	COG0745	RESPONSE REGULATOR receiver
HT750_RS05050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HT750_RS05055	COG0840	transmembrane signaling receptor activity
HT750_RS05060	COG0840	transmembrane signaling receptor activity
HT750_RS05065	COG0835	chemotaxis
HT750_RS05070	COG0643	Histidine kinase
HT750_RS05070	COG2198	Histidine kinase
HT750_RS05075	COG1360	Flagellar Motor Protein
HT750_RS05080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HT750_RS05095	COG0589	response to stress
HT750_RS05105	COG1877	trehalose-phosphatase activity
HT750_RS05110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS05115	COG1129	ABC transporter
HT750_RS05120	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS05125	COG1528	Iron-storage protein
HT750_RS05145	COG1528	Iron-storage protein
HT750_RS05155	COG0814	amino acid
HT750_RS05160	COG3012	SEC-C Motif Domain Protein
HT750_RS05160	COG3318	Belongs to the UPF0149 family
HT750_RS05190	COG2197	response regulator
HT750_RS05205	COG2197	response regulator
HT750_RS05235	COG1191	sigma factor activity
HT750_RS05245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HT750_RS05250	COG1516	flagellar protein fliS
HT750_RS05260	COG0366	Alpha amylase catalytic
HT750_RS05270	COG2391	methyltransferase activity
HT750_RS05275	COG0425	Belongs to the sulfur carrier protein TusA family
HT750_RS05280	COG2135	peptidase activity
HT750_RS05290	COG1766	The M ring may be actively involved in energy transduction
HT750_RS05295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT750_RS05300	COG1317	bacterial-type flagellum organization
HT750_RS05305	COG1157	protein secretion by the type III secretion system
HT750_RS05310	COG2882	bacterial-type flagellum organization
HT750_RS05315	COG3144	bacterial-type flagellum assembly
HT750_RS05320	COG1580	Controls the rotational direction of flagella during chemotaxis
HT750_RS05325	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT750_RS05330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT750_RS05335	COG3190	flagellar
HT750_RS05340	COG1338	Plays a role in the flagellum-specific transport system
HT750_RS05345	COG1987	bacterial-type flagellum assembly
HT750_RS05350	COG1684	flagellar biosynthetic protein fliR
HT750_RS05355	COG2197	response regulator
HT750_RS05380	COG5475	Uncharacterized small protein (DUF2158)
HT750_RS05385	COG2354	Protein conserved in bacteria
HT750_RS05390	COG0697	spore germination
HT750_RS05395	COG3727	T/G mismatch-specific endonuclease activity
HT750_RS05400	COG0270	DNA (cytosine-5-)-methyltransferase activity
HT750_RS05405	COG1418	mRNA catabolic process
HT750_RS05415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HT750_RS05425	COG2205	protein histidine kinase activity
HT750_RS05430	COG0745	RESPONSE REGULATOR receiver
HT750_RS05435	COG2351	hydroxyisourate hydrolase activity
HT750_RS05450	COG3443	Belongs to the bacterial solute-binding protein 9 family
HT750_RS05455	COG3038	cytochrome b561
HT750_RS05485	COG0477	Major facilitator Superfamily
HT750_RS05490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HT750_RS05495	COG0217	transcriptional regulatory protein
HT750_RS05505	COG0534	Mate efflux family protein
HT750_RS05515	COG0583	DNA-binding transcription factor activity
HT750_RS05520	COG0583	DNA-binding transcription factor activity
HT750_RS05530	COG1376	ErfK ybiS ycfS ynhG family protein
HT750_RS05545	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HT750_RS05555	COG4771	TonB-dependent receptor
HT750_RS05570	COG3969	phosphoadenosine phosphosulfate
HT750_RS05585	COG0165	Argininosuccinate lyase
HT750_RS05590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HT750_RS05595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HT750_RS05600	COG2186	Transcriptional regulator
HT750_RS05605	COG4565	transcriptional regulatory protein
HT750_RS05610	COG0252	asparaginase activity
HT750_RS05615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HT750_RS05625	COG2195	Cleaves the N-terminal amino acid of tripeptides
HT750_RS05630	COG3069	C4-dicarboxylate transmembrane transporter activity
HT750_RS05635	COG0675	Transposase, IS605 OrfB family
HT750_RS05645	COG1446	asparaginase
HT750_RS05660	COG0583	DNA-binding transcription factor activity
HT750_RS05670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HT750_RS05690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS05710	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HT750_RS05820	COG2003	Belongs to the UPF0758 family
HT750_RS05855	COG3547	Transposase (IS116 IS110 IS902 family)
HT750_RS05860	COG1289	transmembrane transporter activity
HT750_RS05870	COG1686	Belongs to the peptidase S11 family
HT750_RS05875	COG2925	Exonuclease
HT750_RS05880	COG0425	Belongs to the sulfur carrier protein TusA family
HT750_RS05885	COG2391	methyltransferase activity
HT750_RS05890	COG0531	amino acid
HT750_RS05900	COG0583	DNA-binding transcription factor activity
HT750_RS05905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT750_RS05910	COG4115	mRNA cleavage
HT750_RS05915	COG2161	toxin-antitoxin pair type II binding
HT750_RS05940	COG0131	Imidazoleglycerol-phosphate dehydratase
HT750_RS05940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HT750_RS05945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HT750_RS05965	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HT750_RS05970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HT750_RS05975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HT750_RS05980	COG0438	transferase activity, transferring glycosyl groups
HT750_RS05985	COG1215	transferase activity, transferring glycosyl groups
HT750_RS06000	COG1086	Polysaccharide biosynthesis protein
HT750_RS06020	COG0438	transferase activity, transferring glycosyl groups
HT750_RS06030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HT750_RS06040	COG0438	transferase activity, transferring glycosyl groups
HT750_RS06045	COG2327	Polysaccharide pyruvyl transferase
HT750_RS06050	COG2244	polysaccharide biosynthetic process
HT750_RS06055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HT750_RS06060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HT750_RS06065	COG0662	Cupin 2, conserved barrel domain protein
HT750_RS06065	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HT750_RS06070	COG0297	glycogen (starch) synthase activity
HT750_RS06075	COG1051	belongs to the nudix hydrolase family
HT750_RS06080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT750_RS06085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HT750_RS06090	COG0110	maltose O-acetyltransferase activity
HT750_RS06095	COG1216	Glycosyl transferase, family 2
HT750_RS06105	COG0438	transferase activity, transferring glycosyl groups
HT750_RS06110	COG1045	serine acetyltransferase
HT750_RS06115	COG0463	Glycosyl transferase, family 2
HT750_RS06120	COG3206	protein involved in exopolysaccharide biosynthesis
HT750_RS06120	COG0489	protein tyrosine kinase activity
HT750_RS06125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT750_RS06130	COG1596	polysaccharide export
HT750_RS06135	COG1253	flavin adenine dinucleotide binding
HT750_RS06140	COG2982	Protein involved in outer membrane biogenesis
HT750_RS06150	COG0572	uridine kinase
HT750_RS06155	COG5002	protein histidine kinase activity
HT750_RS06155	COG3447	MASE1 domain protein
HT750_RS06155	COG5001	Diguanylate cyclase
HT750_RS06160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HT750_RS06165	COG0443	Heat shock 70 kDa protein
HT750_RS06170	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HT750_RS06175	COG3779	Protein conserved in bacteria
HT750_RS06180	COG0631	protein serine/threonine phosphatase activity
HT750_RS06185	COG4245	von Willebrand factor, type A
HT750_RS06225	COG2205	protein histidine kinase activity
HT750_RS06230	COG0745	RESPONSE REGULATOR receiver
HT750_RS06240	COG3609	addiction module antidote protein, CC2985 family
HT750_RS06270	COG1063	alcohol dehydrogenase
HT750_RS06275	COG3775	system Galactitol-specific IIC component
HT750_RS06280	COG3414	Phosphotransferase system galactitol-specific IIB component
HT750_RS06285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS06300	COG1830	Aldolase
HT750_RS06305	COG2211	Major facilitator Superfamily
HT750_RS06310	COG1397	ADP-ribosylglycohydrolase
HT750_RS06315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS06320	COG2188	Transcriptional regulator
HT750_RS06325	COG3757	hydrolase, family 25
HT750_RS06330	COG0351	phosphomethylpyrimidine kinase
HT750_RS06390	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HT750_RS06395	COG5455	response to cobalt ion
HT750_RS06400	COG3539	Fimbrial protein
HT750_RS06405	COG3188	usher protein
HT750_RS06410	COG3121	Chaperone
HT750_RS06415	COG3539	Fimbrial protein
HT750_RS06425	COG0489	protein tyrosine kinase activity
HT750_RS06435	COG3831	ATPase activity
HT750_RS06440	COG3831	ATPase activity
HT750_RS06445	COG3831	ATPase activity
HT750_RS06455	COG0714	Associated with various cellular activities
HT750_RS06460	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HT750_RS06465	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HT750_RS06470	COG4715	Zinc finger, swim domain protein
HT750_RS06475	COG4808	Protein conserved in bacteria
HT750_RS06480	COG4807	Protein conserved in bacteria
HT750_RS06485	COG3279	Response regulator of the LytR AlgR family
HT750_RS06490	COG3275	phosphorelay sensor kinase activity
HT750_RS06495	COG0789	Transcriptional regulator
HT750_RS06505	COG1174	glycine betaine transport
HT750_RS06510	COG1125	glycine betaine transport
HT750_RS06515	COG1174	glycine betaine transport
HT750_RS06520	COG1732	Glycine betaine
HT750_RS06525	COG1472	Belongs to the glycosyl hydrolase 3 family
HT750_RS06530	COG0277	FAD linked oxidase domain protein
HT750_RS06535	COG1686	Belongs to the peptidase S11 family
HT750_RS06545	COG0586	Pfam SNARE associated Golgi protein
HT750_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS06575	COG2431	L-lysine efflux transmembrane transporter activity
HT750_RS06580	COG1151	hydroxylamine reductase activity
HT750_RS06585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HT750_RS06590	COG0028	Belongs to the TPP enzyme family
HT750_RS06595	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HT750_RS06600	COG0702	epimerase
HT750_RS06605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT750_RS06610	COG3023	N-Acetylmuramoyl-L-alanine amidase
HT750_RS06630	COG1126	abc transporter atp-binding protein
HT750_RS06635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS06640	COG4215	(ABC) transporter
HT750_RS06645	COG4160	amino acid transport
HT750_RS06650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS06665	COG1177	transmembrane transport
HT750_RS06670	COG1176	ABC-type spermidine putrescine transport system, permease component I
HT750_RS06675	COG3842	ATPase activity
HT750_RS06680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HT750_RS06695	COG0778	Nitroreductase
HT750_RS06705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HT750_RS06720	COG3226	Transcriptional regulator
HT750_RS06725	COG0738	Major facilitator superfamily
HT750_RS06730	COG0561	phosphatase activity
HT750_RS06740	COG2814	Major facilitator Superfamily
HT750_RS06745	COG0671	phosphoesterase, PA-phosphatase related
HT750_RS06750	COG1349	DNA-binding transcription factor activity
HT750_RS06755	COG1686	Belongs to the peptidase S11 family
HT750_RS06760	COG0625	glutathione transferase activity
HT750_RS06765	COG2133	pyrroloquinoline quinone binding
HT750_RS06795	COG2200	EAL domain
HT750_RS06810	COG0747	negative chemotaxis
HT750_RS06820	COG1446	asparaginase
HT750_RS06825	COG0303	'Molybdopterin
HT750_RS06830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HT750_RS06835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HT750_RS06840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HT750_RS06845	COG1882	Formate acetyltransferase
HT750_RS06850	COG0561	phosphatase activity
HT750_RS06865	COG0488	(ABC) transporter
HT750_RS06870	COG1376	ErfK ybiS ycfS ynhG family protein
HT750_RS06875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HT750_RS06880	COG1321	iron dependent repressor
HT750_RS06890	COG2194	sulfuric ester hydrolase activity
HT750_RS06895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HT750_RS06905	COG5006	permease, DMT superfamily
HT750_RS06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS06920	COG0765	amino acid transport
HT750_RS06925	COG1126	abc transporter atp-binding protein
HT750_RS06930	COG0668	transmembrane transport
HT750_RS06945	COG4774	siderophore transport
HT750_RS06955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT750_RS06965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HT750_RS06970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HT750_RS06975	COG1199	ATP-dependent helicase activity
HT750_RS06990	COG0513	Belongs to the DEAD box helicase family
HT750_RS06995	COG1309	transcriptional regulator
HT750_RS07005	COG1131	(ABC) transporter
HT750_RS07010	COG0842	Transport permease protein
HT750_RS07015	COG0842	Transport permease protein
HT750_RS07025	COG3568	Endonuclease Exonuclease Phosphatase
HT750_RS07030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT750_RS07035	COG0392	lysyltransferase activity
HT750_RS07040	COG0670	Belongs to the BI1 family
HT750_RS07045	COG0670	Belongs to the BI1 family
HT750_RS07050	COG0314	molybdopterin synthase activity
HT750_RS07055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HT750_RS07065	COG0521	Mo-molybdopterin cofactor biosynthetic process
HT750_RS07075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HT750_RS07085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HT750_RS07090	COG2226	methyltransferase
HT750_RS07105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT750_RS07110	COG1881	PFAM PEBP family protein
HT750_RS07115	COG4677	pectinesterase activity
HT750_RS07120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HT750_RS07125	COG0471	metal ion transport
HT750_RS07130	COG2828	Protein conserved in bacteria
HT750_RS07135	COG0583	DNA-binding transcription factor activity
HT750_RS07145	COG0561	phosphatase activity
HT750_RS07155	COG4149	molybdate abc transporter
HT750_RS07160	COG0725	ABC transporter, periplasmic molybdate-binding protein
HT750_RS07170	COG2005	Transcriptional regulator
HT750_RS07170	COG3585	molybdate ion transport
HT750_RS07175	COG1119	ATPase activity
HT750_RS07180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HT750_RS07185	COG1085	galactose-1-phosphate uridylyltransferase
HT750_RS07195	COG2017	converts alpha-aldose to the beta-anomer
HT750_RS07205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HT750_RS07215	COG1230	cation diffusion facilitator family transporter
HT750_RS07220	COG3201	nicotinamide mononucleotide transporter
HT750_RS07265	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HT750_RS07270	COG2885	chlorophyll binding
HT750_RS07280	COG3064	Membrane
HT750_RS07285	COG0848	biopolymer transport protein
HT750_RS07290	COG0811	peptide transport
HT750_RS07295	COG0824	Thioesterase
HT750_RS07300	COG3790	cyd operon protein YbgE
HT750_RS07305	COG4890	Cyd operon protein YbgT
HT750_RS07310	COG1294	oxidase, subunit
HT750_RS07315	COG1271	oxidase subunit
HT750_RS07330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HT750_RS07340	COG4865	methylaspartate mutase activity
HT750_RS07345	COG3799	methylaspartate ammonia-lyase activity
HT750_RS07360	COG1301	dicarboxylic acid transport
HT750_RS07365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS07365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS07370	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HT750_RS07375	COG0583	DNA-binding transcription factor activity
HT750_RS07380	COG2986	histidine ammonia-lyase
HT750_RS07385	COG0010	Belongs to the arginase family
HT750_RS07390	COG1228	amidohydrolase
HT750_RS07400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT750_RS07405	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HT750_RS07415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT750_RS07425	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT750_RS07430	COG0567	Dehydrogenase, E1 component
HT750_RS07435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HT750_RS07440	COG1053	succinate dehydrogenase
HT750_RS07445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HT750_RS07450	COG2009	succinate dehydrogenase
HT750_RS07460	COG0372	Belongs to the citrate synthase family
HT750_RS07465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HT750_RS07475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HT750_RS07480	COG2721	sulfolactate sulfo-lyase activity
HT750_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS07495	COG1063	alcohol dehydrogenase
HT750_RS07500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HT750_RS07500	COG0473	3-isopropylmalate dehydrogenase activity
HT750_RS07505	COG2186	Transcriptional regulator
HT750_RS07510	COG3180	Ammonia monooxygenase
HT750_RS07525	COG1984	allophanate hydrolase subunit 2
HT750_RS07530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HT750_RS07535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HT750_RS07545	COG0415	Belongs to the DNA photolyase family
HT750_RS07550	COG3272	Protein of unknown function (DUF1722)
HT750_RS07580	COG2205	protein histidine kinase activity
HT750_RS07585	COG0745	RESPONSE REGULATOR receiver
HT750_RS07595	COG1982	Orn Lys Arg decarboxylase major
HT750_RS07600	COG0531	amino acid
HT750_RS07605	COG0033	Phosphoglucomutase
HT750_RS07610	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HT750_RS07615	COG0596	Alpha beta hydrolase
HT750_RS07625	COG0716	FMN binding
HT750_RS07635	COG0735	belongs to the Fur family
HT750_RS07655	COG1263	PTS System
HT750_RS07655	COG2190	(PTS) system
HT750_RS07655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS07665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HT750_RS07670	COG1940	carbohydrate kinase activity
HT750_RS07670	COG1846	Transcriptional regulator
HT750_RS07675	COG0647	UMP catabolic process
HT750_RS07680	COG0367	asparagine synthase
HT750_RS07725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT750_RS07735	COG1702	phosphate starvation-inducible protein PhoH
HT750_RS07745	COG4535	Mg2 and Co2 transporter CorC
HT750_RS07750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HT750_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS07765	COG0765	amino acid transport
HT750_RS07770	COG0765	amino acid transport
HT750_RS07775	COG1126	abc transporter atp-binding protein
HT750_RS07785	COG0443	Heat shock 70 kDa protein
HT750_RS07790	COG2214	Heat shock protein DnaJ domain protein
HT750_RS07800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HT750_RS07805	COG2214	Heat shock protein DnaJ domain protein
HT750_RS07815	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HT750_RS07820	COG2888	peptidyl-tyrosine sulfation
HT750_RS07835	COG1466	dna polymerase III delta subunit
HT750_RS07845	COG0406	alpha-ribazole phosphatase activity
HT750_RS07850	COG0799	negative regulation of ribosome biogenesis
HT750_RS07860	COG0768	penicillin binding
HT750_RS07865	COG0772	Belongs to the SEDS family
HT750_RS07870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HT750_RS07875	COG1686	Belongs to the peptidase S11 family
HT750_RS07890	COG0583	DNA-binding transcription factor activity
HT750_RS07900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT750_RS07905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT750_RS07925	COG3069	C4-dicarboxylate transmembrane transporter activity
HT750_RS07930	COG4565	transcriptional regulatory protein
HT750_RS07935	COG3290	protein histidine kinase activity
HT750_RS07940	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HT750_RS07950	COG2301	Belongs to the HpcH HpaI aldolase family
HT750_RS07955	COG3051	citrate lyase alpha subunit
HT750_RS07970	COG0471	metal ion transport
HT750_RS07975	COG3719	Belongs to the RNase T2 family
HT750_RS07980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HT750_RS07985	COG0589	response to stress
HT750_RS07990	COG3634	alkyl hydroperoxide reductase activity
HT750_RS07995	COG0450	alkyl hydroperoxide reductase
HT750_RS08000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HT750_RS08005	COG0583	DNA-binding transcription factor activity
HT750_RS08010	COG3969	phosphoadenosine phosphosulfate
HT750_RS08015	COG1475	DNA binding
HT750_RS08020	COG0436	Aminotransferase
HT750_RS08025	COG0371	Dehydrogenase
HT750_RS08030	COG2879	small protein
HT750_RS08035	COG1966	Carbon starvation protein
HT750_RS08040	COG2050	protein possibly involved in aromatic compounds catabolism
HT750_RS08045	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS08050	COG3433	isochorismatase activity
HT750_RS08050	COG1535	isochorismatase
HT750_RS08055	COG1021	2,3-dihydroxybenzoate-AMP ligase
HT750_RS08060	COG1169	isochorismate synthase
HT750_RS08065	COG4592	Periplasmic binding protein
HT750_RS08075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT750_RS08080	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT750_RS08085	COG1120	ATPase activity
HT750_RS08090	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HT750_RS08095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT750_RS08095	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HT750_RS08100	COG3251	PFAM MbtH domain protein
HT750_RS08105	COG2382	esterase
HT750_RS08110	COG4771	TonB-dependent receptor
HT750_RS08115	COG2977	Belongs to the P-Pant transferase superfamily
HT750_RS08135	COG2315	Protein conserved in bacteria
HT750_RS08140	COG0778	Nitroreductase
HT750_RS08145	COG0668	transmembrane transport
HT750_RS08150	COG1113	amino acid transport
HT750_RS08155	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT750_RS08160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS08165	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS08170	COG1538	Outer membrane efflux protein
HT750_RS08175	COG0745	RESPONSE REGULATOR receiver
HT750_RS08180	COG5002	protein histidine kinase activity
HT750_RS08185	COG1215	transferase activity, transferring glycosyl groups
HT750_RS08190	COG4783	chaperone-mediated protein folding
HT750_RS08200	COG2207	Transcriptional regulator
HT750_RS08205	COG4571	Outer membrane protease
HT750_RS08220	COG0500	methyltransferase
HT750_RS08245	COG5301	cellulose 1,4-beta-cellobiosidase activity
HT750_RS08280	COG1196	nuclear chromosome segregation
HT750_RS08330	COG1030	water channel activity
HT750_RS08350	COG4220	transposase activity
HT750_RS08455	COG2076	Multidrug Resistance protein
HT750_RS08545	COG0582	viral genome integration into host DNA
HT750_RS08555	COG2197	response regulator
HT750_RS08560	COG3539	Fimbrial protein
HT750_RS08565	COG3539	Fimbrial protein
HT750_RS08570	COG3188	usher protein
HT750_RS08575	COG3121	Chaperone
HT750_RS08580	COG3539	Fimbrial protein
HT750_RS08590	COG2501	S4 domain
HT750_RS08595	COG1988	membrane-bound metal-dependent
HT750_RS08605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HT750_RS08615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HT750_RS08620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HT750_RS08625	COG0549	Belongs to the carbamate kinase family
HT750_RS08635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT750_RS08640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT750_RS08645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HT750_RS08650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT750_RS08655	COG3257	ureidoglycine aminohydrolase activity
HT750_RS08660	COG1929	Belongs to the glycerate kinase type-1 family
HT750_RS08665	COG2233	PERMEase
HT750_RS08675	COG1953	Uracil, thiamine, allantoin
HT750_RS08680	COG2084	Dehydrogenase
HT750_RS08685	COG3622	Belongs to the hyi family
HT750_RS08690	COG3960	tartronate-semialdehyde synthase activity
HT750_RS08695	COG1414	Transcriptional regulator
HT750_RS08705	COG0583	DNA-binding transcription factor activity
HT750_RS08715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HT750_RS08720	COG4181	ATPase activity
HT750_RS08725	COG2755	lipolytic protein G-D-S-L family
HT750_RS08730	COG0300	oxidoreductase activity
HT750_RS08735	COG3118	belongs to the thioredoxin family
HT750_RS08740	COG0390	transport system, permease component
HT750_RS08745	COG4619	ABC transporter
HT750_RS08750	COG0330	HflC and HflK could
HT750_RS08755	COG1585	Membrane protein implicated in regulation of membrane protease activity
HT750_RS08780	COG0789	Transcriptional regulator
HT750_RS08785	COG0531	amino acid
HT750_RS08795	COG2217	Heavy metal translocating P-type atpase
HT750_RS08800	COG3093	addiction module antidote protein HigA
HT750_RS08805	COG3549	Plasmid maintenance system killer
HT750_RS08810	COG3735	TraB family
HT750_RS08815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HT750_RS08820	COG0737	Belongs to the 5'-nucleotidase family
HT750_RS08825	COG2223	nitrite transmembrane transporter activity
HT750_RS08830	COG4651	solute:proton antiporter activity
HT750_RS08830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HT750_RS08835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS08870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HT750_RS08880	COG2832	Protein of unknown function (DUF454)
HT750_RS08885	COG3923	Primosomal replication protein n
HT750_RS08895	COG3264	Mechanosensitive ion channel
HT750_RS08895	COG1196	nuclear chromosome segregation
HT750_RS08900	COG1309	transcriptional regulator
HT750_RS08905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS08910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT750_RS08925	COG0110	maltose O-acetyltransferase activity
HT750_RS08935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HT750_RS08940	COG5507	3-demethylubiquinone-9 3-methyltransferase
HT750_RS08950	COG3695	enzyme binding
HT750_RS08955	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HT750_RS08960	COG1946	Acyl-CoA thioesterase
HT750_RS08965	COG0004	ammonium transporteR
HT750_RS08970	COG0347	Belongs to the P(II) protein family
HT750_RS08975	COG1132	(ABC) transporter
HT750_RS08980	COG1132	(ABC) transporter
HT750_RS08985	COG1522	sequence-specific DNA binding
HT750_RS08995	COG4533	DNA binding
HT750_RS09005	COG0824	Thioesterase
HT750_RS09010	COG1555	photosystem II stabilization
HT750_RS09015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT750_RS09020	COG0776	regulation of translation
HT750_RS09025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HT750_RS09045	COG0271	Belongs to the BolA IbaG family
HT750_RS09050	COG3056	Lipoprotein
HT750_RS09055	COG2223	nitrite transmembrane transporter activity
HT750_RS09060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HT750_RS09065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HT750_RS09070	COG1845	cytochrome c oxidase, subunit III
HT750_RS09075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HT750_RS09100	COG2814	Major facilitator Superfamily
HT750_RS09110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HT750_RS09115	COG0693	protein deglycase activity
HT750_RS09130	COG0142	geranyltranstransferase activity
HT750_RS09140	COG0667	Aldo Keto reductase
HT750_RS09145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HT750_RS09150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HT750_RS09165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HT750_RS09165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HT750_RS09180	COG0675	Transposase, IS605 OrfB family
HT750_RS09195	COG3248	Nucleoside-binding outer membrane protein
HT750_RS09200	COG1403	HNH endonuclease
HT750_RS09210	COG3609	addiction module antidote protein, CC2985 family
HT750_RS09215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HT750_RS09220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HT750_RS09225	COG1862	Preprotein translocase
HT750_RS09250	COG0366	Alpha amylase catalytic
HT750_RS09255	COG1113	amino acid transport
HT750_RS09260	COG1114	Component of the transport system for branched-chain amino acids
HT750_RS09265	COG5002	protein histidine kinase activity
HT750_RS09270	COG0745	RESPONSE REGULATOR receiver
HT750_RS09275	COG0420	3'-5' exonuclease activity
HT750_RS09280	COG0419	ATPase involved in DNA repair
HT750_RS09285	COG2814	Major facilitator Superfamily
HT750_RS09290	COG1940	carbohydrate kinase activity
HT750_RS09315	COG4126	flavin adenine dinucleotide binding
HT750_RS09335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT750_RS09340	COG3706	GGDEF domain
HT750_RS09350	COG1785	Belongs to the alkaline phosphatase family
HT750_RS09365	COG1181	Belongs to the D-alanine--D-alanine ligase family
HT750_RS09385	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HT750_RS09390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT750_RS09395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT750_RS09400	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS09405	COG0113	porphobilinogen synthase activity
HT750_RS09410	COG2175	clavaminate synthase activity
HT750_RS09415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HT750_RS09425	COG4521	taurine ABC transporter
HT750_RS09430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT750_RS09435	COG1215	transferase activity, transferring glycosyl groups
HT750_RS09465	COG3122	Protein conserved in bacteria
HT750_RS09470	COG2814	Major facilitator Superfamily
HT750_RS09505	COG1414	Transcriptional regulator
HT750_RS09510	COG1609	Transcriptional regulator
HT750_RS09520	COG2223	nitrite transmembrane transporter activity
HT750_RS09525	COG0110	maltose O-acetyltransferase activity
HT750_RS09530	COG2807	transmembrane transport
HT750_RS09540	COG0288	reversible hydration of carbon dioxide
HT750_RS09545	COG0583	DNA-binding transcription factor activity
HT750_RS09550	COG0402	S-adenosylhomocysteine deaminase activity
HT750_RS09555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT750_RS09560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HT750_RS09565	COG2079	MmgE PrpD family protein
HT750_RS09570	COG0372	Belongs to the citrate synthase family
HT750_RS09575	COG1902	pentaerythritol trinitrate reductase activity
HT750_RS09580	COG1073	alpha beta
HT750_RS09585	COG0583	DNA-binding transcription factor activity
HT750_RS09595	COG0667	Aldo Keto reductase
HT750_RS09600	COG0656	L-ascorbic acid biosynthetic process
HT750_RS09605	COG1388	LysM domain
HT750_RS09610	COG2207	Transcriptional regulator
HT750_RS09610	COG3708	Transcriptional regulator
HT750_RS09615	COG0656	L-ascorbic acid biosynthetic process
HT750_RS09620	COG3059	membrane
HT750_RS09630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT750_RS09635	COG2207	Transcriptional regulator
HT750_RS09640	COG0247	lactate metabolic process
HT750_RS09645	COG1139	Iron-sulfur cluster binding protein
HT750_RS09650	COG1556	Lactate utilization protein
HT750_RS09670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HT750_RS09675	COG2200	EAL domain
HT750_RS09675	COG2771	luxR family
HT750_RS09680	COG0583	DNA-binding transcription factor activity
HT750_RS09690	COG0666	response to abiotic stimulus
HT750_RS09700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT750_RS09705	COG1304	FMN binding
HT750_RS09710	COG0549	Belongs to the carbamate kinase family
HT750_RS09715	COG0402	S-adenosylhomocysteine deaminase activity
HT750_RS09720	COG1064	alcohol dehydrogenase
HT750_RS09735	COG1280	lysine exporter protein (LysE YggA)
HT750_RS09745	COG3829	transcription factor binding
HT750_RS09750	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HT750_RS09805	COG0727	PFAM Uncharacterised protein family (UPF0153)
HT750_RS09810	COG3477	response to acidic pH
HT750_RS09915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HT750_RS09935	COG2195	Cleaves the N-terminal amino acid of tripeptides
HT750_RS09950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HT750_RS09955	COG1690	Belongs to the RtcB family
HT750_RS09960	COG0454	-acetyltransferase
HT750_RS09980	COG1943	Transposase
HT750_RS09985	COG0791	NLP P60 protein
HT750_RS09990	COG3077	Addiction module antitoxin, RelB DinJ family
HT750_RS10000	COG3034	peptidoglycan biosynthetic process
HT750_RS10005	COG0121	glutamine amidotransferase
HT750_RS10015	COG1960	acyl-CoA dehydrogenase activity
HT750_RS10025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT750_RS10035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HT750_RS10045	COG2226	methyltransferase
HT750_RS10055	COG0741	lytic transglycosylase activity
HT750_RS10055	COG1388	LysM domain
HT750_RS10060	COG2226	methyltransferase
HT750_RS10070	COG0583	DNA-binding transcription factor activity
HT750_RS10075	COG0656	L-ascorbic acid biosynthetic process
HT750_RS10110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HT750_RS10120	COG2011	ABC-type metal ion transport system permease component
HT750_RS10125	COG1464	Belongs to the NlpA lipoprotein family
HT750_RS10135	COG1720	tRNA m6t6A37 methyltransferase activity
HT750_RS10145	COG0791	NLP P60 protein
HT750_RS10150	COG3015	lipoprotein NlpE involved in copper resistance
HT750_RS10155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HT750_RS10160	COG4681	YaeQ
HT750_RS10170	COG4568	rho-dependent transcription termination
HT750_RS10175	COG0037	tRNA processing
HT750_RS10180	COG0346	lactoylglutathione lyase activity
HT750_RS10195	COG0587	DNA-directed DNA polymerase activity
HT750_RS10200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HT750_RS10220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HT750_RS10225	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HT750_RS10235	COG0750	zinc metalloprotease
HT750_RS10240	COG0575	Belongs to the CDS family
HT750_RS10245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HT750_RS10250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HT750_RS10275	COG0024	Methionine aminopeptidase
HT750_RS10295	COG3835	regulator
HT750_RS10300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT750_RS10315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT750_RS10320	COG2860	membrane
HT750_RS10345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT750_RS10350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT750_RS10355	COG1120	ATPase activity
HT750_RS10360	COG4774	siderophore transport
HT750_RS10365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT750_RS10370	COG1643	Atp-dependent helicase
HT750_RS10375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HT750_RS10385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT750_RS10390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HT750_RS10395	COG0617	tRNA 3'-terminal CCA addition
HT750_RS10400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HT750_RS10405	COG3539	Fimbrial protein
HT750_RS10410	COG3121	Chaperone
HT750_RS10415	COG3188	usher protein
HT750_RS10420	COG3539	Fimbrial protein
HT750_RS10425	COG3539	Fimbrial protein
HT750_RS10430	COG3539	Fimbrial protein
HT750_RS10435	COG3539	Fimbrial protein
HT750_RS10450	COG5464	transposase or invertase
HT750_RS10460	COG0726	polysaccharide deacetylase
HT750_RS10465	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS10470	COG0842	Transport permease protein
HT750_RS10475	COG1131	(ABC) transporter
HT750_RS10480	COG0288	reversible hydration of carbon dioxide
HT750_RS10485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HT750_RS10490	COG4993	Dehydrogenase
HT750_RS10495	COG2132	Multicopper oxidase
HT750_RS10520	COG1049	propionate catabolic process, 2-methylcitrate cycle
HT750_RS10525	COG3064	Membrane
HT750_RS10530	COG3547	Transposase (IS116 IS110 IS902 family)
HT750_RS10535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT750_RS10540	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT750_RS10545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HT750_RS10550	COG2186	Transcriptional regulator
HT750_RS10555	COG1113	amino acid transport
HT750_RS10560	COG3725	Membrane protein required for beta-lactamase induction
HT750_RS10565	COG3023	N-Acetylmuramoyl-L-alanine amidase
HT750_RS10570	COG0157	Belongs to the NadC ModD family
HT750_RS10575	COG4969	Belongs to the N-Me-Phe pilin family
HT750_RS10580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HT750_RS10585	COG1459	type II secretion system
HT750_RS10595	COG0237	dephospho-CoA kinase activity
HT750_RS10610	COG0494	nUDIX hydrolase
HT750_RS10630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HT750_RS10635	COG0849	cell division
HT750_RS10640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HT750_RS10645	COG1181	Belongs to the D-alanine--D-alanine ligase family
HT750_RS10660	COG0772	Belongs to the SEDS family
HT750_RS10675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HT750_RS10680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HT750_RS10685	COG0768	penicillin binding
HT750_RS10690	COG3116	cell division
HT750_RS10705	COG1609	Transcriptional regulator
HT750_RS10715	COG0440	acetolactate synthase activity
HT750_RS10720	COG0028	Belongs to the TPP enzyme family
HT750_RS10730	COG0583	DNA-binding transcription factor activity
HT750_RS10775	COG4143	(ABC) transporter
HT750_RS10780	COG1178	ABC-type Fe3 transport system permease component
HT750_RS10790	COG0586	Pfam SNARE associated Golgi protein
HT750_RS10805	COG4977	sequence-specific DNA binding
HT750_RS10820	COG0235	Class ii aldolase
HT750_RS10825	COG0417	DNA replication proofreading
HT750_RS10835	COG0564	pseudouridine synthase activity
HT750_RS10840	COG3547	Transposase (IS116 IS110 IS902 family)
HT750_RS10845	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HT750_RS10855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT750_RS10895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT750_RS10900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HT750_RS10900	COG0475	glutathione-regulated potassium exporter activity
HT750_RS10910	COG2271	Major facilitator Superfamily
HT750_RS10915	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HT750_RS10920	COG0644	oxidoreductase
HT750_RS10970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HT750_RS10975	COG0505	Belongs to the CarA family
HT750_RS10995	COG1047	Peptidyl-prolyl cis-trans
HT750_RS11010	COG0196	riboflavin kinase activity
HT750_RS11035	COG0583	DNA-binding transcription factor activity
HT750_RS11040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HT750_RS11050	COG3119	arylsulfatase activity
HT750_RS11080	COG4735	regulation of single-species biofilm formation
HT750_RS11085	COG1584	GPR1 FUN34 yaaH family protein
HT750_RS11090	COG0521	Mo-molybdopterin cofactor biosynthetic process
HT750_RS11100	COG1115	amino acid carrier protein
HT750_RS11115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HT750_RS11125	COG0527	aspartate kinase activity
HT750_RS11125	COG0460	homoserine dehydrogenase
HT750_RS11135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HT750_RS11145	COG0745	RESPONSE REGULATOR receiver
HT750_RS11150	COG4452	Inner membrane protein CreD
HT750_RS11155	COG2205	protein histidine kinase activity
HT750_RS11160	COG0745	RESPONSE REGULATOR receiver
HT750_RS11165	COG3045	CreA protein
HT750_RS11170	COG2207	Transcriptional regulator
HT750_RS11170	COG3708	Transcriptional regulator
HT750_RS11190	COG0741	lytic transglycosylase activity
HT750_RS11195	COG0488	(ABC) transporter
HT750_RS11205	COG1056	cytidyltransferase-related domain
HT750_RS11205	COG3172	ATPase kinase involved in NAD metabolism
HT750_RS11210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HT750_RS11215	COG0560	Phosphoserine phosphatase
HT750_RS11220	COG3726	membrane protein affecting hemolysin expression
HT750_RS11255	COG1328	CTP reductase activity
HT750_RS11260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HT750_RS11265	COG0084	hydrolase, TatD family'
HT750_RS11270	COG4667	esterase of the alpha-beta hydrolase superfamily
HT750_RS11280	COG2823	Periplasmic or secreted lipoprotein
HT750_RS11290	COG1011	Hydrolase
HT750_RS11295	COG0456	acetyltransferase
HT750_RS11300	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HT750_RS11330	COG4114	ferric iron reductase
HT750_RS11335	COG2197	response regulator
HT750_RS11340	COG2197	response regulator
HT750_RS11345	COG2966	Psort location CytoplasmicMembrane, score
HT750_RS11360	COG1484	DNA-dependent DNA replication
HT750_RS11375	COG1063	alcohol dehydrogenase
HT750_RS11380	COG1802	Transcriptional regulator
HT750_RS11385	COG2271	Major facilitator Superfamily
HT750_RS11390	COG0840	transmembrane signaling receptor activity
HT750_RS11400	COG4145	pantothenate transmembrane transporter activity
HT750_RS11410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HT750_RS11420	COG1966	Carbon starvation protein
HT750_RS11425	COG2879	small protein
HT750_RS11430	COG0523	cobalamin synthesis protein
HT750_RS11445	COG1715	Restriction endonuclease
HT750_RS11465	COG5457	Domain of unknown function (DUF1127)
HT750_RS11470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT750_RS11485	COG2814	Major facilitator Superfamily
HT750_RS11490	COG2733	membrane
HT750_RS11495	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HT750_RS11500	COG1924	4 iron, 4 sulfur cluster binding
HT750_RS11515	COG0477	Major facilitator Superfamily
HT750_RS11525	COG3366	ferrous iron transmembrane transporter activity
HT750_RS11530	COG0700	Nucleoside recognition
HT750_RS11535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HT750_RS11540	COG0583	DNA-binding transcription factor activity
HT750_RS11560	COG2186	Transcriptional regulator
HT750_RS11565	COG0246	Mannitol dehydrogenase
HT750_RS11575	COG2610	gluconate transmembrane transporter activity
HT750_RS11580	COG3539	Fimbrial protein
HT750_RS11585	COG3539	Fimbrial protein
HT750_RS11590	COG3539	Fimbrial protein
HT750_RS11595	COG3188	usher protein
HT750_RS11600	COG3121	Chaperone
HT750_RS11605	COG3539	Fimbrial protein
HT750_RS11610	COG3539	Fimbrial protein
HT750_RS11615	COG4974	Belongs to the 'phage' integrase family
HT750_RS11620	COG0582	viral genome integration into host DNA
HT750_RS11625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HT750_RS11630	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HT750_RS11650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HT750_RS11665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HT750_RS11670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HT750_RS11680	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HT750_RS11680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT750_RS11685	COG0328	RNA-DNA hybrid ribonuclease activity
HT750_RS11700	COG1064	alcohol dehydrogenase
HT750_RS11705	COG3265	gluconokinase activity
HT750_RS11710	COG1063	alcohol dehydrogenase
HT750_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS11720	COG2610	gluconate transmembrane transporter activity
HT750_RS11725	COG1609	Transcriptional regulator
HT750_RS11730	COG0433	COG0433 Predicted ATPase
HT750_RS11735	COG0795	lipopolysaccharide-transporting ATPase activity
HT750_RS11740	COG0795	lipopolysaccharide-transporting ATPase activity
HT750_RS11750	COG2927	DNA polymerase III (CHI subunit)
HT750_RS11755	COG0525	valine-tRNA ligase activity
HT750_RS11760	COG4269	membrane
HT750_RS11765	COG0456	acetyltransferase
HT750_RS11770	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HT750_RS11785	COG2731	YhcH YjgK YiaL family protein
HT750_RS11790	COG1309	transcriptional regulator
HT750_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS11800	COG0251	oxidation-reduction process
HT750_RS11820	COG0251	oxidation-reduction process
HT750_RS11825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HT750_RS11835	COG1609	Transcriptional regulator
HT750_RS11840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS11840	COG1263	PTS System
HT750_RS11845	COG0366	Alpha amylase catalytic
HT750_RS11850	COG1328	CTP reductase activity
HT750_RS11855	COG0602	queuosine metabolic process
HT750_RS11860	COG2026	Addiction module toxin, RelE StbE family
HT750_RS11865	COG3077	Addiction module antitoxin, RelB DinJ family
HT750_RS11870	COG3783	Cytochrome b(562)
HT750_RS11875	COG0312	modulator of DNA gyrase
HT750_RS11885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HT750_RS11895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS11900	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS11905	COG1129	ABC transporter
HT750_RS11910	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS11915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HT750_RS11920	COG2337	Toxic component of a toxin-antitoxin (TA) module
HT750_RS11925	COG2336	PFAM SpoVT AbrB
HT750_RS11930	COG2105	PFAM AIG2 family protein
HT750_RS11935	COG2911	Protein conserved in bacteria
HT750_RS11940	COG0729	surface antigen
HT750_RS11950	COG1253	flavin adenine dinucleotide binding
HT750_RS11960	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HT750_RS11965	COG1218	3'(2'),5'-bisphosphate nucleotidase
HT750_RS11970	COG0737	Belongs to the 5'-nucleotidase family
HT750_RS11975	COG1733	regulation of RNA biosynthetic process
HT750_RS11980	COG0702	epimerase
HT750_RS11985	COG0697	spore germination
HT750_RS11995	COG1113	amino acid transport
HT750_RS12000	COG0545	Peptidyl-prolyl cis-trans isomerase
HT750_RS12005	COG3061	Opacity-associated protein A
HT750_RS12010	COG1309	transcriptional regulator
HT750_RS12025	COG1024	Enoyl-CoA hydratase
HT750_RS12030	COG4670	ketone body catabolic process
HT750_RS12035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HT750_RS12040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HT750_RS12050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HT750_RS12060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HT750_RS12105	COG3037	sugar-specific permease SgaT UlaA
HT750_RS12120	COG1073	alpha beta
HT750_RS12125	COG3650	response to hydrogen peroxide
HT750_RS12135	COG1960	acyl-CoA dehydrogenase activity
HT750_RS12140	COG0754	glutathionylspermidine amidase activity
HT750_RS12145	COG5463	Belongs to the UPF0441 family
HT750_RS12150	COG3766	membrane
HT750_RS12160	COG1842	Phage shock protein A
HT750_RS12165	COG3789	protein conserved in bacteria
HT750_RS12170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT750_RS12175	COG0557	exoribonuclease II activity
HT750_RS12190	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HT750_RS12195	COG0330	HflC and HflK could
HT750_RS12200	COG0330	HflC and HflK could
HT750_RS12205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HT750_RS12225	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT750_RS12230	COG0802	atpase or kinase
HT750_RS12235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HT750_RS12235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HT750_RS12280	COG1511	domain protein
HT750_RS12280	COG3264	Mechanosensitive ion channel
HT750_RS12305	COG0531	amino acid
HT750_RS12315	COG1053	succinate dehydrogenase
HT750_RS12320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HT750_RS12340	COG3040	lipid binding
HT750_RS12345	COG2076	Multidrug Resistance protein
HT750_RS12350	COG5510	response to toxic substance
HT750_RS12355	COG5510	response to toxic substance
HT750_RS12365	COG1509	lysine 2,3-aminomutase activity
HT750_RS12390	COG0531	amino acid
HT750_RS12395	COG3030	protein affecting phage T7 exclusion by the F plasmid
HT750_RS12400	COG1027	Aspartate ammonia-lyase
HT750_RS12405	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HT750_RS12420	COG1309	transcriptional regulator
HT750_RS12430	COG3710	Transcriptional regulator
HT750_RS12435	COG0531	amino acid
HT750_RS12440	COG1982	Orn Lys Arg decarboxylase major
HT750_RS12445	COG3104	oligopeptide transport
HT750_RS12450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HT750_RS12465	COG2388	GCN5-related N-acetyl-transferase
HT750_RS12470	COG3592	Divergent 4Fe-4S mono-cluster
HT750_RS12475	COG3290	protein histidine kinase activity
HT750_RS12480	COG4565	transcriptional regulatory protein
HT750_RS12485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HT750_RS12490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS12490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS12495	COG3647	Membrane
HT750_RS12500	COG1486	melibiose metabolic process
HT750_RS12505	COG2169	Transcriptional regulator
HT750_RS12510	COG1982	Orn Lys Arg decarboxylase major
HT750_RS12515	COG2207	Transcriptional regulator
HT750_RS12520	COG0531	amino acid
HT750_RS12525	COG2194	sulfuric ester hydrolase activity
HT750_RS12530	COG0745	RESPONSE REGULATOR receiver
HT750_RS12535	COG0642	Histidine kinase
HT750_RS12545	COG0477	Major facilitator Superfamily
HT750_RS12555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HT750_RS12560	COG2824	Alkylphosphonate utilization operon protein PhnA
HT750_RS12565	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HT750_RS12575	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HT750_RS12580	COG3639	organic phosphonate transmembrane transporter activity
HT750_RS12585	COG2188	Transcriptional regulator
HT750_RS12590	COG3624	Phosphonate C-P lyase system protein PhnG
HT750_RS12595	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HT750_RS12600	COG3626	phosphonate metabolism
HT750_RS12605	COG3627	carbon phosphorus lyase activity
HT750_RS12610	COG4107	phosphonate C-P lyase system protein PhnK
HT750_RS12615	COG4778	phosphonate C-P lyase system protein PhnL
HT750_RS12620	COG3454	Phosphonate metabolism
HT750_RS12630	COG0456	acetyltransferase
HT750_RS12635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HT750_RS12645	COG0698	ribose 5-phosphate isomerase
HT750_RS12650	COG1737	Transcriptional regulator
HT750_RS12655	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS12660	COG1129	ABC transporter
HT750_RS12665	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS12670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HT750_RS12675	COG1940	carbohydrate kinase activity
HT750_RS12680	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HT750_RS12690	COG1566	PFAM secretion protein HlyD family protein
HT750_RS12695	COG1289	transmembrane transporter activity
HT750_RS12710	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HT750_RS12715	COG1301	dicarboxylic acid transport
HT750_RS12720	COG4235	cytochrome complex assembly
HT750_RS12725	COG3088	subunit of a heme lyase
HT750_RS12730	COG1138	Cytochrome C-type biogenesis protein
HT750_RS12735	COG3301	Polysulphide reductase, NrfD
HT750_RS12740	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS12745	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HT750_RS12755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HT750_RS12760	COG3162	membrane
HT750_RS12770	COG0025	NhaP-type Na H and K H
HT750_RS12775	COG2252	PERMEase
HT750_RS12780	COG0789	Transcriptional regulator
HT750_RS12785	COG2207	Transcriptional regulator
HT750_RS12790	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HT750_RS12800	COG0629	single-stranded DNA binding
HT750_RS12805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HT750_RS12810	COG2315	Protein conserved in bacteria
HT750_RS12815	COG0432	Pfam Uncharacterised protein family UPF0047
HT750_RS12820	COG3700	Belongs to the class B bacterial acid phosphatase family
HT750_RS12830	COG1448	Aminotransferase
HT750_RS12835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HT750_RS12840	COG0305	Participates in initiation and elongation during chromosome replication
HT750_RS12845	COG0604	alcohol dehydrogenase
HT750_RS12855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT750_RS12865	COG0735	belongs to the Fur family
HT750_RS12870	COG3237	CsbD-like
HT750_RS12875	COG0534	Mate efflux family protein
HT750_RS12885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HT750_RS12905	COG1357	PFAM Pentapeptide repeats (8 copies)
HT750_RS12920	COG3842	ATPase activity
HT750_RS12925	COG2182	Extracellular solute-binding protein
HT750_RS12930	COG1175	transmembrane transport
HT750_RS12935	COG3833	ABC-type maltose transport systems, permease component
HT750_RS12950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HT750_RS12975	COG0527	aspartate kinase activity
HT750_RS12990	COG0741	lytic transglycosylase activity
HT750_RS13070	COG5301	cellulose 1,4-beta-cellobiosidase activity
HT750_RS13085	COG3541	Predicted nucleotidyltransferase
HT750_RS13100	COG1187	pseudouridine synthase activity
HT750_RS13140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HT750_RS13150	COG1283	sodium-dependent phosphate transmembrane transporter activity
HT750_RS13165	COG1410	methionine synthase
HT750_RS13165	COG0646	methionine synthase
HT750_RS13170	COG1414	Transcriptional regulator
HT750_RS13180	COG2224	Isocitrate lyase
HT750_RS13185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HT750_RS13195	COG0456	acetyltransferase
HT750_RS13225	COG0151	Belongs to the GarS family
HT750_RS13230	COG2204	response regulator
HT750_RS13235	COG4191	Histidine kinase
HT750_RS13240	COG3678	ATP-independent chaperone mediated protein folding
HT750_RS13255	COG3068	Protein conserved in bacteria
HT750_RS13290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HT750_RS13295	COG2104	thiamine diphosphate biosynthetic process
HT750_RS13305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HT750_RS13325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS13360	COG0250	Participates in transcription elongation, termination and antitermination
HT750_RS13365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HT750_RS13400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HT750_RS13400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HT750_RS13430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HT750_RS13435	COG4206	TonB-dependent receptor
HT750_RS13450	COG1309	transcriptional regulator
HT750_RS13460	COG0583	DNA-binding transcription factor activity
HT750_RS13465	COG2271	Major facilitator Superfamily
HT750_RS13470	COG4948	Mandelate Racemase Muconate Lactonizing
HT750_RS13485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HT750_RS13500	COG2194	sulfuric ester hydrolase activity
HT750_RS13505	COG2207	Transcriptional regulator
HT750_RS13510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS13515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HT750_RS13520	COG1882	Formate acetyltransferase
HT750_RS13525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS13530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS13535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS13535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS13535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HT750_RS13540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HT750_RS13545	COG0371	Dehydrogenase
HT750_RS13550	COG3738	Protein conserved in bacteria
HT750_RS13555	COG0697	spore germination
HT750_RS13565	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HT750_RS13570	COG0737	Belongs to the 5'-nucleotidase family
HT750_RS13580	COG0737	Belongs to the 5'-nucleotidase family
HT750_RS13585	COG0737	Belongs to the 5'-nucleotidase family
HT750_RS13595	COG0460	homoserine dehydrogenase
HT750_RS13595	COG0527	aspartate kinase activity
HT750_RS13600	COG0626	cystathionine gamma-synthase activity
HT750_RS13610	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HT750_RS13620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HT750_RS13625	COG1609	Transcriptional regulator
HT750_RS13630	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HT750_RS13645	COG1575	Belongs to the MenA family. Type 1 subfamily
HT750_RS13670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HT750_RS13680	COG1494	fructose-1,6-bisphosphatase
HT750_RS13690	COG0589	response to stress
HT750_RS13695	COG3691	Protein conserved in bacteria
HT750_RS13700	COG3152	Membrane
HT750_RS13720	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HT750_RS13735	COG3678	ATP-independent chaperone mediated protein folding
HT750_RS13740	COG0745	RESPONSE REGULATOR receiver
HT750_RS13745	COG2205	protein histidine kinase activity
HT750_RS13750	COG3547	Transposase (IS116 IS110 IS902 family)
HT750_RS13755	COG2258	MOSC domain
HT750_RS13765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HT750_RS13775	COG1917	Cupin 2, conserved barrel domain protein
HT750_RS13775	COG4977	sequence-specific DNA binding
HT750_RS13790	COG4806	L-rhamnose isomerase
HT750_RS13810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS13815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS13815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS13820	COG1363	Peptidase, m42
HT750_RS13825	COG3711	transcriptional antiterminator
HT750_RS13825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS13840	COG0326	Molecular chaperone. Has ATPase activity
HT750_RS13855	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS13860	COG2864	formate dehydrogenase
HT750_RS13875	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HT750_RS13880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HT750_RS13890	COG0456	acetyltransferase
HT750_RS13905	COG1011	Hydrolase
HT750_RS13910	COG1349	DNA-binding transcription factor activity
HT750_RS13915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS13920	COG2084	Dehydrogenase
HT750_RS13925	COG3684	Belongs to the aldolase LacD family
HT750_RS13930	COG2942	2-epimerase
HT750_RS13935	COG2017	converts alpha-aldose to the beta-anomer
HT750_RS13940	COG1501	Belongs to the glycosyl hydrolase 31 family
HT750_RS13945	COG2211	Major facilitator Superfamily
HT750_RS13950	COG2211	Major facilitator Superfamily
HT750_RS13955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HT750_RS13960	COG2271	Major facilitator Superfamily
HT750_RS13965	COG1082	Xylose isomerase domain protein TIM barrel
HT750_RS13970	COG2188	Transcriptional regulator
HT750_RS13975	COG3385	transposase activity
HT750_RS13985	COG0174	glutamine synthetase
HT750_RS13990	COG3852	Histidine kinase
HT750_RS13995	COG2204	response regulator
HT750_RS14005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HT750_RS14020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT750_RS14020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT750_RS14025	COG0204	Acyl-transferase
HT750_RS14030	COG5339	Protein conserved in bacteria
HT750_RS14035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HT750_RS14040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT750_RS14045	COG3084	Protein conserved in bacteria
HT750_RS14050	COG0746	molybdenum cofactor guanylyltransferase activity
HT750_RS14055	COG1763	Mo-molybdopterin cofactor biosynthetic process
HT750_RS14085	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HT750_RS14090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HT750_RS14095	COG1739	Uncharacterized protein family UPF0029
HT750_RS14115	COG0543	2 iron, 2 sulfur cluster binding
HT750_RS14120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HT750_RS14125	COG0250	Participates in transcription elongation, termination and antitermination
HT750_RS14135	COG0805	protein transport
HT750_RS14140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT750_RS14145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT750_RS14155	COG3165	ubiquinone biosynthetic process from chorismate
HT750_RS14165	COG1322	Protein conserved in bacteria
HT750_RS14170	COG1414	Transcriptional regulator
HT750_RS14175	COG3734	2-keto-3-deoxy-galactonokinase
HT750_RS14180	COG0800	Aldolase
HT750_RS14200	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HT750_RS14205	COG0412	Dienelactone hydrolase
HT750_RS14210	COG1335	isochorismatase
HT750_RS14220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT750_RS14225	COG1304	FMN binding
HT750_RS14230	COG0549	Belongs to the carbamate kinase family
HT750_RS14240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT750_RS14245	COG0583	DNA-binding transcription factor activity
HT750_RS14255	COG0583	DNA-binding transcription factor activity
HT750_RS14260	COG0697	spore germination
HT750_RS14265	COG0561	phosphatase activity
HT750_RS14270	COG2267	carboxylic ester hydrolase activity
HT750_RS14275	COG1280	lysine exporter protein (LysE YggA)
HT750_RS14280	COG1280	lysine exporter protein (LysE YggA)
HT750_RS14285	COG0514	ATP-dependent DNA helicase (RecQ)
HT750_RS14290	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HT750_RS14295	COG2050	protein possibly involved in aromatic compounds catabolism
HT750_RS14300	COG2962	Rard protein
HT750_RS14315	COG0598	Magnesium transport protein CorA
HT750_RS14320	COG3698	Phosphodiester glycosidase
HT750_RS14325	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HT750_RS14330	COG0210	DNA helicase
HT750_RS14335	COG1011	Hydrolase
HT750_RS14345	COG3159	Protein conserved in bacteria
HT750_RS14355	COG5567	small periplasmic lipoprotein
HT750_RS14375	COG3072	Adenylate cyclase
HT750_RS14385	COG1587	Uroporphyrinogen-III synthase
HT750_RS14390	COG2959	enzyme of heme biosynthesis
HT750_RS14395	COG3071	HemY protein
HT750_RS14400	COG3119	arylsulfatase activity
HT750_RS14405	COG0641	radical SAM
HT750_RS14430	COG1113	amino acid transport
HT750_RS14450	COG2244	polysaccharide biosynthetic process
HT750_RS14455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT750_RS14460	COG0456	acetyltransferase
HT750_RS14465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HT750_RS14470	COG1088	dTDP-glucose 4,6-dehydratase activity
HT750_RS14475	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HT750_RS14480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HT750_RS14485	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HT750_RS14490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HT750_RS14495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HT750_RS14505	COG3118	belongs to the thioredoxin family
HT750_RS14520	COG0210	DNA helicase
HT750_RS14525	COG3692	DNA binding
HT750_RS14530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT750_RS14540	COG0583	DNA-binding transcription factor activity
HT750_RS14545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HT750_RS14555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT750_RS14560	COG3978	acetolactate synthase activity
HT750_RS14580	COG0606	chelatase, subunit chli
HT750_RS14585	COG3085	chromosome segregation
HT750_RS14625	COG2186	Transcriptional regulator
HT750_RS14630	COG0477	Major facilitator Superfamily
HT750_RS14635	COG1609	Transcriptional regulator
HT750_RS14640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS14645	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS14650	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS14655	COG1129	ABC transporter
HT750_RS14685	COG1522	sequence-specific DNA binding
HT750_RS14690	COG0716	FMN binding
HT750_RS14705	COG3312	ion transport
HT750_RS14780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HT750_RS14785	COG0573	inorganic phosphate transmembrane transporter activity
HT750_RS14790	COG0581	inorganic phosphate transmembrane transporter activity
HT750_RS14795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT750_RS14800	COG0704	Plays a role in the regulation of phosphate uptake
HT750_RS14830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT750_RS14835	COG2252	PERMEase
HT750_RS14840	COG0431	NADPH-dependent FMN reductase
HT750_RS14845	COG2091	lysine biosynthetic process via aminoadipic acid
HT750_RS14850	COG0583	DNA-binding transcription factor activity
HT750_RS14860	COG0814	amino acid
HT750_RS14910	COG0592	DNA-directed DNA polymerase activity
HT750_RS14920	COG0187	DNA topoisomerase II activity
HT750_RS14925	COG3753	Protein conserved in bacteria
HT750_RS14930	COG0561	phosphatase activity
HT750_RS14940	COG2186	Transcriptional regulator
HT750_RS14945	COG3734	2-keto-3-deoxy-galactonokinase
HT750_RS14950	COG0800	Aldolase
HT750_RS14960	COG2271	Major facilitator Superfamily
HT750_RS14970	COG0823	Involved in the tonB-independent uptake of proteins
HT750_RS14975	COG5645	(Lipo)protein
HT750_RS14995	COG2188	Transcriptional regulator
HT750_RS15010	COG2207	Transcriptional regulator
HT750_RS15015	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT750_RS15020	COG3119	arylsulfatase activity
HT750_RS15025	COG2149	membrane
HT750_RS15035	COG0641	radical SAM
HT750_RS15040	COG2814	Major facilitator Superfamily
HT750_RS15055	COG0028	Belongs to the TPP enzyme family
HT750_RS15060	COG0440	acetolactate synthase activity
HT750_RS15075	COG2197	response regulator
HT750_RS15080	COG3851	Histidine kinase
HT750_RS15085	COG2271	Major facilitator Superfamily
HT750_RS15090	COG2271	Major facilitator Superfamily
HT750_RS15100	COG2252	PERMEase
HT750_RS15155	COG0457	Tetratricopeptide repeat
HT750_RS15165	COG1464	Belongs to the NlpA lipoprotein family
HT750_RS15170	COG0697	spore germination
HT750_RS15175	COG2814	Major facilitator Superfamily
HT750_RS15190	COG2211	Major facilitator Superfamily
HT750_RS15195	COG1501	Belongs to the glycosyl hydrolase 31 family
HT750_RS15200	COG3711	transcriptional antiterminator
HT750_RS15205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS15205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS15205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS15210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS15215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS15215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS15230	COG1940	carbohydrate kinase activity
HT750_RS15240	COG2982	Protein involved in outer membrane biogenesis
HT750_RS15245	COG2233	PERMEase
HT750_RS15250	COG0786	glutamate:sodium symporter activity
HT750_RS15255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HT750_RS15260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT750_RS15265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HT750_RS15275	COG0194	GDP metabolic process
HT750_RS15285	COG2860	membrane
HT750_RS15290	COG3645	SOS response
HT750_RS15400	COG1561	YicC-like family, N-terminal region
HT750_RS15425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HT750_RS15455	COG1519	Transferase
HT750_RS15460	COG0859	PFAM glycosyl transferase family 9
HT750_RS15465	COG0438	transferase activity, transferring glycosyl groups
HT750_RS15470	COG0515	serine threonine protein kinase
HT750_RS15485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HT750_RS15490	COG1442	glycosyl transferase family 8
HT750_RS15495	COG1216	Glycosyl transferase, family 2
HT750_RS15500	COG3307	-O-antigen
HT750_RS15505	COG0859	PFAM glycosyl transferase family 9
HT750_RS15510	COG0859	PFAM glycosyl transferase family 9
HT750_RS15520	COG0156	8-amino-7-oxononanoate synthase activity
HT750_RS15530	COG1216	Glycosyl transferase, family 2
HT750_RS15535	COG2861	carbohydrate metabolic process
HT750_RS15540	COG4942	peptidase
HT750_RS15550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT750_RS15555	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HT750_RS15570	COG1045	serine acetyltransferase
HT750_RS15575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HT750_RS15585	COG2186	Transcriptional regulator
HT750_RS15590	COG1620	l-lactate permease
HT750_RS15595	COG5295	Hep Hag repeat protein
HT750_RS15615	COG3722	fumarate hydratase activity
HT750_RS15625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS15625	COG2213	PTS system mannitol-specific
HT750_RS15635	COG1566	PFAM secretion protein HlyD family protein
HT750_RS15680	COG3210	domain, Protein
HT750_RS15680	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS15685	COG0625	glutathione transferase activity
HT750_RS15695	COG3276	selenocysteine insertion sequence binding
HT750_RS15700	COG1454	alcohol dehydrogenase
HT750_RS15710	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS15725	COG1598	PFAM Uncharacterised protein family UPF0150
HT750_RS15735	COG2211	Major facilitator Superfamily
HT750_RS15745	COG0235	Class ii aldolase
HT750_RS15750	COG3623	hexulose-6-phosphate isomerase
HT750_RS15755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HT750_RS15760	COG1070	Carbohydrate kinase
HT750_RS15765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HT750_RS15770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HT750_RS15775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HT750_RS15780	COG2731	YhcH YjgK YiaL family protein
HT750_RS15790	COG1414	Transcriptional regulator
HT750_RS15795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS15800	COG3977	Valine--pyruvate aminotransferase
HT750_RS15805	COG0366	Alpha amylase catalytic
HT750_RS15810	COG2992	FlgJ-related protein
HT750_RS15815	COG1609	Transcriptional regulator
HT750_RS15815	COG2207	Transcriptional regulator
HT750_RS15820	COG4214	carbohydrate transport
HT750_RS15825	COG1129	ABC transporter
HT750_RS15830	COG4213	ABC transporter substrate-binding protein
HT750_RS15840	COG1070	Carbohydrate kinase
HT750_RS15845	COG4682	membrane
HT750_RS15850	COG4682	membrane
HT750_RS15855	COG3274	enterobacterial common antigen metabolic process
HT750_RS15885	COG1278	Cold shock
HT750_RS15890	COG2944	sequence-specific DNA binding
HT750_RS15905	COG2885	chlorophyll binding
HT750_RS15910	COG0243	molybdopterin cofactor binding
HT750_RS15915	COG0456	acetyltransferase
HT750_RS15920	COG2818	Glycosylase
HT750_RS15925	COG5571	outer membrane autotransporter
HT750_RS15930	COG2223	nitrite transmembrane transporter activity
HT750_RS15935	COG2194	sulfuric ester hydrolase activity
HT750_RS15945	COG0747	negative chemotaxis
HT750_RS15950	COG0601	transmembrane transport
HT750_RS15955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT750_RS15960	COG0444	Belongs to the ABC transporter superfamily
HT750_RS15965	COG4608	Belongs to the ABC transporter superfamily
HT750_RS15970	COG0814	amino acid
HT750_RS15985	COG2194	sulfuric ester hydrolase activity
HT750_RS16010	COG1215	transferase activity, transferring glycosyl groups
HT750_RS16015	COG1215	transferase activity, transferring glycosyl groups
HT750_RS16020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HT750_RS16025	COG0457	Tetratricopeptide repeat
HT750_RS16025	COG3118	belongs to the thioredoxin family
HT750_RS16030	COG2199	diguanylate cyclase activity
HT750_RS16030	COG2200	EAL domain
HT750_RS16040	COG0612	Peptidase, M16
HT750_RS16045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS16050	COG2200	EAL domain
HT750_RS16055	COG2982	Protein involved in outer membrane biogenesis
HT750_RS16060	COG0477	Major facilitator Superfamily
HT750_RS16065	COG1295	ribonuclease BN
HT750_RS16070	COG0583	DNA-binding transcription factor activity
HT750_RS16075	COG2197	response regulator
HT750_RS16085	COG1858	cytochrome C peroxidase
HT750_RS16090	COG0076	glutamate decarboxylase activity
HT750_RS16110	COG2207	Transcriptional regulator
HT750_RS16115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT750_RS16120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS16130	COG2771	luxR family
HT750_RS16135	COG3247	response to pH
HT750_RS16150	COG1285	pathogenesis
HT750_RS16160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT750_RS16170	COG3721	Heme iron utilization protein
HT750_RS16185	COG4771	TonB-dependent receptor
HT750_RS16190	COG3720	iron ion transport
HT750_RS16195	COG2197	response regulator
HT750_RS16200	COG3065	identical protein binding
HT750_RS16220	COG1393	Belongs to the ArsC family
HT750_RS16225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HT750_RS16230	COG0640	Transcriptional regulator
HT750_RS16240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT750_RS16245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HT750_RS16250	COG0339	signal peptide processing
HT750_RS16260	COG3104	oligopeptide transport
HT750_RS16265	COG0589	response to stress
HT750_RS16275	COG0306	phosphate transporter
HT750_RS16280	COG2081	HI0933 family
HT750_RS16300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS16305	COG0842	Transport permease protein
HT750_RS16305	COG1129	ABC transporter
HT750_RS16310	COG0842	Transport permease protein
HT750_RS16340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT750_RS16345	COG0601	transmembrane transport
HT750_RS16350	COG0747	negative chemotaxis
HT750_RS16355	COG2091	lysine biosynthetic process via aminoadipic acid
HT750_RS16360	COG0628	permease
HT750_RS16365	COG0477	Major facilitator Superfamily
HT750_RS16375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HT750_RS16395	COG3714	YhhN family
HT750_RS16405	COG3776	membrane
HT750_RS16410	COG0742	ribosomal rna small subunit methyltransferase
HT750_RS16415	COG0552	protein localization to endoplasmic reticulum
HT750_RS16420	COG2884	Cell division ATP-binding protein ftsE
HT750_RS16425	COG2177	Part of the ABC transporter FtsEX involved in
HT750_RS16430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HT750_RS16435	COG0683	leucine binding
HT750_RS16440	COG0456	acetyltransferase
HT750_RS16445	COG0683	leucine binding
HT750_RS16450	COG0559	Belongs to the binding-protein-dependent transport system permease family
HT750_RS16455	COG4177	L-phenylalanine transmembrane transporter activity
HT750_RS16460	COG0411	ABC transporter
HT750_RS16465	COG0410	ABC transporter
HT750_RS16470	COG1653	transport
HT750_RS16475	COG1175	transmembrane transport
HT750_RS16480	COG0395	ABC-type sugar transport system, permease component
HT750_RS16485	COG3842	ATPase activity
HT750_RS16490	COG0584	glycerophosphoryl diester phosphodiesterase
HT750_RS16500	COG0405	Gamma-glutamyltransferase
HT750_RS16520	COG3157	Type VI secretion system effector, Hcp
HT750_RS16525	COG1247	-acetyltransferase
HT750_RS16530	COG0673	inositol 2-dehydrogenase activity
HT750_RS16535	COG1741	Belongs to the pirin family
HT750_RS16540	COG1609	Transcriptional regulator
HT750_RS16545	COG3265	gluconokinase activity
HT750_RS16550	COG2610	gluconate transmembrane transporter activity
HT750_RS16555	COG0514	ATP-dependent DNA helicase (RecQ)
HT750_RS16565	COG2095	MarC family integral membrane protein
HT750_RS16570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HT750_RS16575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HT750_RS16595	COG0058	SHG alpha-glucan phosphorylase activity
HT750_RS16600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HT750_RS16615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HT750_RS16630	COG1349	DNA-binding transcription factor activity
HT750_RS16635	COG4650	regulator
HT750_RS16640	COG1690	Belongs to the RtcB family
HT750_RS16655	COG0058	SHG alpha-glucan phosphorylase activity
HT750_RS16660	COG1640	4-alpha-glucanotransferase
HT750_RS16665	COG2610	gluconate transmembrane transporter activity
HT750_RS16675	COG1040	competence protein
HT750_RS16685	COG5464	transposase or invertase
HT750_RS16695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HT750_RS16700	COG1918	ferrous iron import across plasma membrane
HT750_RS16705	COG2183	response to ionizing radiation
HT750_RS16710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HT750_RS16715	COG0745	RESPONSE REGULATOR receiver
HT750_RS16720	COG2205	protein histidine kinase activity
HT750_RS16740	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HT750_RS16750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HT750_RS16755	COG1011	Hydrolase
HT750_RS16765	COG0494	nUDIX hydrolase
HT750_RS16770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HT750_RS16775	COG4972	Pilus assembly protein
HT750_RS16780	COG3166	PFAM Fimbrial assembly family protein
HT750_RS16795	COG4796	Type ii and iii secretion system protein
HT750_RS16810	COG3266	domain, Protein
HT750_RS16815	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HT750_RS16820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HT750_RS16830	COG0180	Tryptophanyl-tRNA synthetase
HT750_RS16835	COG2188	Transcriptional regulator
HT750_RS16845	COG3457	Alanine racemase
HT750_RS16850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HT750_RS16855	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HT750_RS16870	COG0626	cystathionine gamma-synthase activity
HT750_RS16885	COG2116	formate transmembrane transporter activity
HT750_RS16890	COG2146	nitrite reductase [NAD(P)H] activity
HT750_RS16895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT750_RS16905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HT750_RS16915	COG2184	nucleotidyltransferase activity
HT750_RS16920	COG0512	Glutamine amidotransferase of anthranilate synthase
HT750_RS16925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HT750_RS16930	COG1289	transmembrane transporter activity
HT750_RS16935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT750_RS16940	COG1765	OsmC-like protein
HT750_RS16945	COG3954	Phosphoribulokinase
HT750_RS16955	COG0429	hydrolase of the alpha beta-hydrolase fold
HT750_RS16960	COG0488	(ABC) transporter
HT750_RS16975	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HT750_RS16980	COG1047	Peptidyl-prolyl cis-trans
HT750_RS16990	COG0545	Peptidyl-prolyl cis-trans isomerase
HT750_RS16995	COG2964	Protein conserved in bacteria
HT750_RS17065	COG0089	rRNA binding
HT750_RS17155	COG0201	protein transport
HT750_RS17195	COG0789	Transcriptional regulator
HT750_RS17200	COG3036	rescue of stalled ribosome
HT750_RS17210	COG0569	domain protein
HT750_RS17230	COG0758	DNA mediated transformation
HT750_RS17240	COG0551	DNA topoisomerase type I activity
HT750_RS17260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HT750_RS17300	COG1126	abc transporter atp-binding protein
HT750_RS17305	COG0765	amino acid transport
HT750_RS17310	COG4597	amino acid ABC transporter
HT750_RS17315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS17325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT750_RS17330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS17335	COG1309	transcriptional regulator
HT750_RS17345	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HT750_RS17355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT750_RS17365	COG4145	pantothenate transmembrane transporter activity
HT750_RS17370	COG3924	membrane
HT750_RS17375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS17380	COG1349	DNA-binding transcription factor activity
HT750_RS17390	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS17395	COG1129	ABC transporter
HT750_RS17400	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS17405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS17415	COG0439	Biotin carboxylase
HT750_RS17420	COG0511	ligase activity, forming carbon-carbon bonds
HT750_RS17425	COG0604	alcohol dehydrogenase
HT750_RS17430	COG2200	EAL domain
HT750_RS17430	COG2199	diguanylate cyclase activity
HT750_RS17435	COG1077	Cell shape determining protein MreB Mrl
HT750_RS17440	COG1792	Involved in formation and maintenance of cell shape
HT750_RS17445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HT750_RS17455	COG1530	ribonuclease E activity
HT750_RS17460	COG3164	Protein of unknown function
HT750_RS17465	COG0312	modulator of DNA gyrase
HT750_RS17470	COG0583	DNA-binding transcription factor activity
HT750_RS17490	COG2732	(Barnase) inhibitor
HT750_RS17510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT750_RS17515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT750_RS17520	COG3105	Protein conserved in bacteria
HT750_RS17525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HT750_RS17545	COG0625	glutathione transferase activity
HT750_RS17550	COG2969	positive regulation of protein catabolic process
HT750_RS17555	COG3069	C4-dicarboxylate transmembrane transporter activity
HT750_RS17585	COG2731	YhcH YjgK YiaL family protein
HT750_RS17590	COG4804	nuclease activity
HT750_RS17595	COG0493	'glutamate synthase
HT750_RS17600	COG0067	glutamate synthase
HT750_RS17600	COG0069	glutamate synthase activity
HT750_RS17600	COG0070	glutamate synthase
HT750_RS17605	COG1242	4 iron, 4 sulfur cluster binding
HT750_RS17610	COG5002	protein histidine kinase activity
HT750_RS17610	COG2198	Histidine kinase
HT750_RS17610	COG0784	Response regulator, receiver
HT750_RS17615	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HT750_RS17625	COG0515	serine threonine protein kinase
HT750_RS17630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS17645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HT750_RS17650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HT750_RS17655	COG1137	ATPase activity
HT750_RS17660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HT750_RS17665	COG3117	lipopolysaccharide transmembrane transporter activity
HT750_RS17670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HT750_RS17675	COG0517	IMP dehydrogenase activity
HT750_RS17675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HT750_RS17680	COG0530	calcium, potassium:sodium antiporter activity
HT750_RS17685	COG1127	ABC transporter
HT750_RS17690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HT750_RS17695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HT750_RS17700	COG2854	intermembrane phospholipid transfer
HT750_RS17705	COG3113	response to antibiotic
HT750_RS17710	COG5007	Belongs to the BolA IbaG family
HT750_RS17720	COG3423	Transcriptional regulator
HT750_RS17725	COG0142	geranyltranstransferase activity
HT750_RS17740	COG0697	spore germination
HT750_RS17750	COG2027	D-alanyl-D-alanine carboxypeptidase
HT750_RS17755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HT750_RS17760	COG1534	Rna-binding protein
HT750_RS17770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HT750_RS17775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HT750_RS17785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HT750_RS17795	COG2194	sulfuric ester hydrolase activity
HT750_RS17815	COG0195	Participates in both transcription termination and antitermination
HT750_RS17855	COG0513	Belongs to the DEAD box helicase family
HT750_RS17860	COG0814	amino acid
HT750_RS17865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT750_RS17870	COG0826	peptidase U32
HT750_RS17875	COG0826	peptidase U32
HT750_RS17880	COG3154	lipid carrier protein
HT750_RS17885	COG3153	acetyltransferase
HT750_RS17900	COG0693	protein deglycase activity
HT750_RS17905	COG0702	epimerase
HT750_RS17910	COG0701	Predicted permease
HT750_RS17915	COG2823	Periplasmic or secreted lipoprotein
HT750_RS17935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HT750_RS17940	COG0363	glucosamine-6-phosphate deaminase activity
HT750_RS17945	COG3716	PTS system mannose fructose sorbose family IID component
HT750_RS17950	COG3715	PTS system
HT750_RS17955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS17965	COG2222	sugar isomerase
HT750_RS17970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HT750_RS17975	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS17980	COG3716	PTS system mannose fructose sorbose family IID component
HT750_RS17990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS18000	COG1349	DNA-binding transcription factor activity
HT750_RS18010	COG2002	toxin-antitoxin pair type II binding
HT750_RS18015	COG2721	sulfolactate sulfo-lyase activity
HT750_RS18020	COG2271	Major facilitator Superfamily
HT750_RS18030	COG2084	Dehydrogenase
HT750_RS18035	COG1929	Belongs to the glycerate kinase type-1 family
HT750_RS18060	COG0583	DNA-binding transcription factor activity
HT750_RS18065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HT750_RS18075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HT750_RS18080	COG1882	Formate acetyltransferase
HT750_RS18085	COG0251	oxidation-reduction process
HT750_RS18090	COG1760	l-serine dehydratase
HT750_RS18095	COG0814	amino acid
HT750_RS18110	COG1741	Belongs to the pirin family
HT750_RS18115	COG0583	DNA-binding transcription factor activity
HT750_RS18120	COG3152	Membrane
HT750_RS18125	COG3152	Membrane
HT750_RS18130	COG0435	Glutathione S-transferase
HT750_RS18135	COG2259	Doxx family
HT750_RS18145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HT750_RS18150	COG4575	ribosome binding
HT750_RS18155	COG1422	Protein of unknown function (DUF1090)
HT750_RS18165	COG0586	Pfam SNARE associated Golgi protein
HT750_RS18170	COG2186	Transcriptional regulator
HT750_RS18195	COG2271	Major facilitator Superfamily
HT750_RS18205	COG2721	sulfolactate sulfo-lyase activity
HT750_RS18215	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HT750_RS18220	COG0861	Integral membrane protein TerC family
HT750_RS18225	COG0673	inositol 2-dehydrogenase activity
HT750_RS18230	COG2949	membrane
HT750_RS18235	COG1451	nucleotide metabolic process
HT750_RS18245	COG0446	pyridine nucleotide-disulphide oxidoreductase
HT750_RS18245	COG1902	pentaerythritol trinitrate reductase activity
HT750_RS18250	COG3408	Glycogen debranching enzyme
HT750_RS18250	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HT750_RS18260	COG0531	amino acid
HT750_RS18265	COG2731	YhcH YjgK YiaL family protein
HT750_RS18270	COG3250	beta-galactosidase activity
HT750_RS18275	COG1609	Transcriptional regulator
HT750_RS18280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT750_RS18290	COG0840	transmembrane signaling receptor activity
HT750_RS18295	COG1695	Transcriptional regulator
HT750_RS18300	COG2375	cellular response to nickel ion
HT750_RS18330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT750_RS18370	COG0243	molybdopterin cofactor binding
HT750_RS18375	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS18380	COG3302	dmso reductase anchor subunit
HT750_RS18385	COG3381	protein complex oligomerization
HT750_RS18395	COG3039	Transposase
HT750_RS18420	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS18435	COG2003	Belongs to the UPF0758 family
HT750_RS18480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HT750_RS18485	COG0358	DNA primase activity
HT750_RS18490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HT750_RS18505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS18510	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HT750_RS18525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HT750_RS18540	COG4991	sh3 domain protein
HT750_RS18545	COG3025	triphosphatase activity
HT750_RS18565	COG2268	Band 7 protein
HT750_RS18570	COG1585	Membrane protein implicated in regulation of membrane protease activity
HT750_RS18580	COG3539	Fimbrial protein
HT750_RS18585	COG3121	Chaperone
HT750_RS18590	COG3188	usher protein
HT750_RS18595	COG3539	Fimbrial protein
HT750_RS18600	COG2960	long-chain fatty acid transporting porin activity
HT750_RS18620	COG3384	dioxygenase
HT750_RS18625	COG0754	glutathionylspermidine amidase activity
HT750_RS18635	COG1538	Outer membrane efflux protein
HT750_RS18640	COG0494	nUDIX hydrolase
HT750_RS18645	COG3151	Protein conserved in bacteria
HT750_RS18650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HT750_RS18655	COG3150	esterase
HT750_RS18660	COG0187	DNA topoisomerase II activity
HT750_RS18665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HT750_RS18670	COG2249	NAD(P)H dehydrogenase (quinone) activity
HT750_RS18680	COG0642	Histidine kinase
HT750_RS18685	COG0745	RESPONSE REGULATOR receiver
HT750_RS18690	COG3111	PFAM Bacterial OB fold (BOF) protein
HT750_RS18695	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HT750_RS18705	COG2944	sequence-specific DNA binding
HT750_RS18710	COG4166	transmembrane transport
HT750_RS18715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HT750_RS18720	COG0204	Acyl-transferase
HT750_RS18725	COG2132	Multicopper oxidase
HT750_RS18730	COG1032	radical SAM domain protein
HT750_RS18735	COG4238	major outer membrane lipoprotein
HT750_RS18745	COG0656	L-ascorbic acid biosynthetic process
HT750_RS18750	COG1979	alcohol dehydrogenase
HT750_RS18755	COG2207	Transcriptional regulator
HT750_RS18760	COG0586	Pfam SNARE associated Golgi protein
HT750_RS18765	COG0626	cystathionine gamma-synthase activity
HT750_RS18770	COG0811	peptide transport
HT750_RS18775	COG0848	biopolymer transport protein
HT750_RS18780	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS18790	COG0667	Aldo Keto reductase
HT750_RS18805	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HT750_RS18810	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS18815	COG5557	Pfam Polysulphide reductase, NrfD
HT750_RS18820	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HT750_RS18825	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HT750_RS18830	COG1773	rubredoxin
HT750_RS18840	COG0298	carbon dioxide binding
HT750_RS18845	COG0625	glutathione transferase activity
HT750_RS18850	COG0754	glutathionylspermidine amidase activity
HT750_RS18855	COG0306	phosphate transporter
HT750_RS18860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT750_RS18865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT750_RS18870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT750_RS18875	COG2244	polysaccharide biosynthetic process
HT750_RS18885	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HT750_RS18890	COG0795	lipopolysaccharide-transporting ATPase activity
HT750_RS18900	COG0156	8-amino-7-oxononanoate synthase activity
HT750_RS18905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT750_RS18920	COG0456	acetyltransferase
HT750_RS18925	COG2186	Transcriptional regulator
HT750_RS18930	COG0277	FAD linked oxidase domain protein
HT750_RS18935	COG0277	FAD linked oxidase domain protein
HT750_RS18940	COG0247	lactate metabolic process
HT750_RS18945	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HT750_RS18950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HT750_RS18955	COG1620	l-lactate permease
HT750_RS18970	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HT750_RS19005	COG2003	Belongs to the UPF0758 family
HT750_RS19030	COG3596	GTP binding
HT750_RS19185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HT750_RS19220	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HT750_RS19235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HT750_RS19315	COG3069	C4-dicarboxylate transmembrane transporter activity
HT750_RS19325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HT750_RS19350	COG1653	transport
HT750_RS19400	COG0582	viral genome integration into host DNA
HT750_RS19410	COG1811	Na channel or pump
HT750_RS19415	COG1982	Orn Lys Arg decarboxylase major
HT750_RS19420	COG2211	Major facilitator Superfamily
HT750_RS19435	COG1194	a g-specific adenine glycosylase
HT750_RS19445	COG3171	Protein conserved in bacteria
HT750_RS19455	COG0252	asparaginase activity
HT750_RS19465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HT750_RS19480	COG0762	integral membrane protein
HT750_RS19485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HT750_RS19490	COG2805	Type II/IV secretion system protein
HT750_RS19505	COG0189	ligase activity
HT750_RS19510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HT750_RS19515	COG2356	endonuclease I
HT750_RS19525	COG2814	Major facilitator Superfamily
HT750_RS19545	COG1166	arginine decarboxylase activity
HT750_RS19555	COG0501	Belongs to the peptidase M48B family
HT750_RS19560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HT750_RS19570	COG2213	PTS system mannitol-specific
HT750_RS19575	COG1063	alcohol dehydrogenase
HT750_RS19580	COG1494	fructose-1,6-bisphosphatase
HT750_RS19585	COG3722	fumarate hydratase activity
HT750_RS19590	COG1072	(Pantothenic acid kinase))
HT750_RS19605	COG0191	fructose-bisphosphate aldolase activity
HT750_RS19610	COG0668	transmembrane transport
HT750_RS19615	COG1279	arginine transmembrane transporter activity
HT750_RS19620	COG2968	Membrane
HT750_RS19625	COG0583	DNA-binding transcription factor activity
HT750_RS19630	COG0427	acetyl-CoA hydrolase
HT750_RS19635	COG1024	Enoyl-CoA hydratase
HT750_RS19640	COG1703	isobutyryl-CoA mutase activity
HT750_RS19645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HT750_RS19645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HT750_RS19665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HT750_RS19675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HT750_RS19695	COG0006	proline dipeptidase activity
HT750_RS19700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT750_RS19705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT750_RS19730	COG2723	6-phospho-beta-galactosidase activity
HT750_RS19740	COG1272	protein, Hemolysin III
HT750_RS19750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HT750_RS19760	COG0716	FMN binding
HT750_RS19765	COG4974	Belongs to the 'phage' integrase family
HT750_RS19770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HT750_RS19775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HT750_RS19785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HT750_RS19800	COG2233	PERMEase
HT750_RS19810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS19815	COG2252	PERMEase
HT750_RS19820	COG0402	S-adenosylhomocysteine deaminase activity
HT750_RS19825	COG2233	PERMEase
HT750_RS19830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HT750_RS19830	COG2080	2 iron, 2 sulfur cluster binding
HT750_RS19835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HT750_RS19840	COG0402	S-adenosylhomocysteine deaminase activity
HT750_RS19845	COG0493	'glutamate synthase
HT750_RS19845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS19850	COG2068	MobA-Related Protein
HT750_RS19855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HT750_RS19860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HT750_RS19860	COG3608	succinylglutamate desuccinylase aspartoacylase
HT750_RS19865	COG0549	Belongs to the carbamate kinase family
HT750_RS19875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT750_RS19880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HT750_RS19885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HT750_RS19895	COG2080	2 iron, 2 sulfur cluster binding
HT750_RS19900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HT750_RS19905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HT750_RS19910	COG4942	peptidase
HT750_RS19920	COG0814	amino acid
HT750_RS19925	COG0183	Belongs to the thiolase family
HT750_RS19935	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS19940	COG2814	Major facilitator Superfamily
HT750_RS19945	COG1794	racemase activity, acting on amino acids and derivatives
HT750_RS19950	COG0583	DNA-binding transcription factor activity
HT750_RS19960	COG1609	Transcriptional regulator
HT750_RS19975	COG0667	Aldo Keto reductase
HT750_RS19985	COG0861	Integral membrane protein TerC family
HT750_RS20000	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HT750_RS20015	COG2165	general secretion pathway protein
HT750_RS20020	COG4795	General secretion pathway protein
HT750_RS20030	COG4967	type IV pilus modification protein PilV
HT750_RS20035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HT750_RS20040	COG1025	Belongs to the peptidase M16 family
HT750_RS20045	COG1074	ATP-dependent DNA helicase activity
HT750_RS20050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HT750_RS20055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HT750_RS20055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HT750_RS20060	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT750_RS20065	COG3711	transcriptional antiterminator
HT750_RS20070	COG1263	PTS System
HT750_RS20070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS20075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HT750_RS20105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HT750_RS20110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HT750_RS20115	COG2166	iron-sulfur cluster assembly
HT750_RS20120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HT750_RS20130	COG0583	DNA-binding transcription factor activity
HT750_RS20135	COG2363	Small membrane protein
HT750_RS20145	COG1349	DNA-binding transcription factor activity
HT750_RS20155	COG1070	Carbohydrate kinase
HT750_RS20165	COG0738	Major facilitator superfamily
HT750_RS20170	COG0235	Class ii aldolase
HT750_RS20175	COG1454	alcohol dehydrogenase
HT750_RS20185	COG1760	l-serine dehydratase
HT750_RS20190	COG0814	amino acid
HT750_RS20195	COG1611	Belongs to the LOG family
HT750_RS20210	COG3098	single-species biofilm formation
HT750_RS20215	COG0564	pseudouridine synthase activity
HT750_RS20220	COG0716	FMN binding
HT750_RS20225	COG2271	Major facilitator Superfamily
HT750_RS20230	COG4948	Mandelate Racemase Muconate Lactonizing
HT750_RS20235	COG4948	Mandelate Racemase Muconate Lactonizing
HT750_RS20240	COG2205	protein histidine kinase activity
HT750_RS20240	COG3437	response regulator, receiver
HT750_RS20240	COG3850	Histidine kinase
HT750_RS20240	COG4999	Histidine kinase
HT750_RS20250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HT750_RS20255	COG2336	PFAM SpoVT AbrB
HT750_RS20260	COG2337	Toxic component of a toxin-antitoxin (TA) module
HT750_RS20265	COG3956	TIGRFAM MazG family protein
HT750_RS20280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HT750_RS20290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HT750_RS20300	COG0602	queuosine metabolic process
HT750_RS20330	COG1070	Carbohydrate kinase
HT750_RS20335	COG2223	nitrite transmembrane transporter activity
HT750_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS20345	COG0277	FAD linked oxidase domain protein
HT750_RS20350	COG0477	Major facilitator Superfamily
HT750_RS20355	COG2086	electron transfer activity
HT750_RS20360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HT750_RS20365	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HT750_RS20370	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HT750_RS20375	COG0644	oxidoreductase
HT750_RS20380	COG0720	synthase
HT750_RS20405	COG2234	aminopeptidase activity
HT750_RS20460	COG1388	LysM domain
HT750_RS20460	COG4942	peptidase
HT750_RS20465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HT750_RS20475	COG0163	prenyltransferase activity
HT750_RS20480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HT750_RS20490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HT750_RS20515	COG3604	Transcriptional regulator
HT750_RS20520	COG0309	Hydrogenase expression formation protein (HypE)
HT750_RS20525	COG0409	Hydrogenase expression formation protein
HT750_RS20530	COG0298	carbon dioxide binding
HT750_RS20535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HT750_RS20540	COG0375	protein maturation
HT750_RS20550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS20555	COG0651	ATP synthesis coupled electron transport
HT750_RS20560	COG0650	Formate hydrogenlyase subunit 4
HT750_RS20565	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HT750_RS20565	COG3261	NADH dehydrogenase
HT750_RS20570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HT750_RS20575	COG3260	NADH ubiquinone oxidoreductase 20
HT750_RS20585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HT750_RS20595	COG2723	6-phospho-beta-galactosidase activity
HT750_RS20600	COG1263	PTS System
HT750_RS20600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS20605	COG1609	Transcriptional regulator
HT750_RS20610	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS20615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HT750_RS20640	COG1349	DNA-binding transcription factor activity
HT750_RS20645	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS20650	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS20660	COG3732	PTS system glucitol sorbitol-specific
HT750_RS20665	COG3730	PTS system glucitol sorbitol-specific
HT750_RS20670	COG2951	lytic endotransglycosylase activity
HT750_RS20675	COG1546	Belongs to the CinA family
HT750_RS20695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HT750_RS20725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT750_RS20730	COG1238	metal cluster binding
HT750_RS20745	COG2814	Major facilitator Superfamily
HT750_RS20750	COG1566	PFAM secretion protein HlyD family protein
HT750_RS20755	COG1846	Transcriptional regulator
HT750_RS20765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HT750_RS20770	COG2814	Major facilitator Superfamily
HT750_RS20775	COG2113	Glycine betaine
HT750_RS20780	COG4176	ABC-type proline glycine betaine transport system permease component
HT750_RS20785	COG4175	Glycine betaine
HT750_RS20790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT750_RS20795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT750_RS20805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HT750_RS20810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT750_RS20815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT750_RS20820	COG4575	ribosome binding
HT750_RS20835	COG2916	Histone family protein nucleoid-structuring protein H-NS
HT750_RS20840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT750_RS20845	COG0640	Transcriptional regulator
HT750_RS20850	COG0401	homolog of Blt101
HT750_RS20855	COG1652	LysM domain
HT750_RS20860	COG1802	Transcriptional regulator
HT750_RS20865	COG1113	amino acid transport
HT750_RS20870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HT750_RS20875	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS20880	COG0579	oxidoreductase
HT750_RS20915	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS20930	COG2867	negative regulation of translational initiation
HT750_RS20940	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HT750_RS20945	COG0497	DNA recombination
HT750_RS20960	COG4536	flavin adenine dinucleotide binding
HT750_RS20965	COG4137	Cytochrome C assembly protein
HT750_RS20970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HT750_RS20995	COG2885	chlorophyll binding
HT750_RS21000	COG2199	diguanylate cyclase activity
HT750_RS21015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HT750_RS21020	COG1605	Chorismate mutase
HT750_RS21020	COG0287	Prephenate dehydrogenase
HT750_RS21025	COG1605	Chorismate mutase
HT750_RS21025	COG0077	Prephenate dehydratase
HT750_RS21035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HT750_RS21040	COG3385	transposase activity
HT750_RS21045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HT750_RS21050	COG0564	pseudouridine synthase activity
HT750_RS21060	COG0542	response to heat
HT750_RS21085	COG0477	Major facilitator Superfamily
HT750_RS21090	COG5544	Lipoprotein
HT750_RS21095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT750_RS21100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT750_RS21100	COG0045	succinate-CoA ligase (ADP-forming) activity
HT750_RS21100	COG1042	CoA-binding domain protein
HT750_RS21110	COG3118	belongs to the thioredoxin family
HT750_RS21115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT750_RS21135	COG0583	DNA-binding transcription factor activity
HT750_RS21140	COG0513	Belongs to the DEAD box helicase family
HT750_RS21150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HT750_RS21160	COG1595	DNA-templated transcription, initiation
HT750_RS21165	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HT750_RS21170	COG3026	antisigma factor binding
HT750_RS21175	COG3086	response to oxidative stress
HT750_RS21185	COG0681	Belongs to the peptidase S26 family
HT750_RS21205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HT750_RS21220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS21225	COG1737	Transcriptional regulator
HT750_RS21230	COG0560	Phosphoserine phosphatase
HT750_RS21235	COG0590	tRNA wobble adenosine to inosine editing
HT750_RS21245	COG0047	phosphoribosylformylglycinamidine synthase activity
HT750_RS21245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HT750_RS21250	COG2205	protein histidine kinase activity
HT750_RS21255	COG3170	Tfp pilus assembly protein FimV
HT750_RS21260	COG2204	response regulator
HT750_RS21265	COG0347	Belongs to the P(II) protein family
HT750_RS21270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HT750_RS21270	COG1017	nitric oxide dioxygenase activity
HT750_RS21280	COG1940	carbohydrate kinase activity
HT750_RS21285	COG0457	Tetratricopeptide repeat
HT750_RS21290	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS21295	COG1129	ABC transporter
HT750_RS21300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT750_RS21305	COG1063	alcohol dehydrogenase
HT750_RS21310	COG2017	converts alpha-aldose to the beta-anomer
HT750_RS21315	COG2259	Doxx family
HT750_RS21340	COG4638	Rieske (2fe-2S)
HT750_RS21345	COG0583	DNA-binding transcription factor activity
HT750_RS21350	COG2814	Major facilitator Superfamily
HT750_RS21355	COG3711	transcriptional antiterminator
HT750_RS21360	COG1073	alpha beta
HT750_RS21365	COG0483	inositol monophosphate 1-phosphatase activity
HT750_RS21385	COG0822	iron-sulfur transferase activity
HT750_RS21405	COG0633	Ferredoxin
HT750_RS21410	COG2975	iron-sulfur cluster assembly
HT750_RS21425	COG2897	thiosulfate sulfurtransferase activity
HT750_RS21430	COG2373	Large extracellular alpha-helical protein
HT750_RS21435	COG4953	penicillin-binding protein 1C
HT750_RS21465	COG2976	Protein conserved in bacteria
HT750_RS21480	COG1645	bacterial-type flagellum-dependent swarming motility
HT750_RS21505	COG0516	GMP reductase activity
HT750_RS21505	COG0517	IMP dehydrogenase activity
HT750_RS21520	COG3133	Outer membrane lipoprotein
HT750_RS21535	COG2200	EAL domain
HT750_RS21540	COG0248	Ppx GppA phosphatase
HT750_RS21545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HT750_RS21550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HT750_RS21565	COG2233	PERMEase
HT750_RS21575	COG1393	Belongs to the ArsC family
HT750_RS21580	COG4783	chaperone-mediated protein folding
HT750_RS21585	COG0628	permease
HT750_RS21590	COG2116	formate transmembrane transporter activity
HT750_RS21595	COG3604	Transcriptional regulator
HT750_RS21605	COG3260	NADH ubiquinone oxidoreductase 20
HT750_RS21610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HT750_RS21615	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HT750_RS21615	COG3261	NADH dehydrogenase
HT750_RS21620	COG0651	ATP synthesis coupled electron transport
HT750_RS21625	COG4237	Hydrogenase 4 membrane
HT750_RS21630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HT750_RS21635	COG0650	Formate hydrogenlyase subunit 4
HT750_RS21640	COG0651	ATP synthesis coupled electron transport
HT750_RS21645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS21650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HT750_RS21655	COG2716	regulation of RNA biosynthetic process
HT750_RS21665	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HT750_RS21675	COG2321	neutral zinc metallopeptidase
HT750_RS21685	COG0400	carboxylic ester hydrolase activity
HT750_RS21700	COG1393	Belongs to the ArsC family
HT750_RS21710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT750_RS21715	COG3850	Histidine kinase
HT750_RS21720	COG0493	'glutamate synthase
HT750_RS21720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS21730	COG5342	invasion associated locus B
HT750_RS21735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HT750_RS21740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HT750_RS21745	COG0280	phosphate acetyltransferase
HT750_RS21745	COG0281	malic enzyme
HT750_RS21750	COG4810	utilization protein
HT750_RS21755	COG4917	ethanolamine utilization protein
HT750_RS21760	COG4766	ethanolamine catabolic process
HT750_RS21765	COG4812	Cobalamin adenosyltransferase
HT750_RS21770	COG0280	phosphate acetyltransferase
HT750_RS21775	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HT750_RS21780	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HT750_RS21785	COG1012	belongs to the aldehyde dehydrogenase family
HT750_RS21790	COG4820	ethanolamine utilization protein (EutJ)
HT750_RS21795	COG1454	alcohol dehydrogenase
HT750_RS21800	COG3192	ethanolamine utilization protein
HT750_RS21805	COG4819	ethanolamine utilization protein
HT750_RS21810	COG4303	Ethanolamine ammonia lyase large subunit
HT750_RS21820	COG4816	utilization protein
HT750_RS21825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HT750_RS21830	COG2207	Transcriptional regulator
HT750_RS21840	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT750_RS21860	COG2837	iron assimilation
HT750_RS21865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT750_RS21870	COG1263	PTS System
HT750_RS21870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT750_RS21885	COG1028	Short-chain dehydrogenase reductase Sdr
HT750_RS21890	COG4150	thiosulfate binding
HT750_RS21895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HT750_RS21900	COG4208	sulfate ABC transporter
HT750_RS21905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HT750_RS21910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT750_RS21925	COG2190	(PTS) system
HT750_RS21930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HT750_RS21935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS21940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT750_RS21960	COG3530	Putative quorum-sensing-regulated virulence factor
HT750_RS21965	COG0385	Bile acid
HT750_RS21970	COG0583	DNA-binding transcription factor activity
HT750_RS21980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HT750_RS21985	COG2211	Major facilitator Superfamily
HT750_RS21995	COG0583	DNA-binding transcription factor activity
HT750_RS22035	COG3415	Transposase
HT750_RS22040	COG3415	Transposase
HT750_RS22055	COG2200	EAL domain
HT750_RS22055	COG2199	diguanylate cyclase activity
HT750_RS22060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT750_RS22085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS22090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS22095	COG0006	proline dipeptidase activity
HT750_RS22100	COG1363	Peptidase, m42
HT750_RS22110	COG2207	Transcriptional regulator
HT750_RS22115	COG3279	Response regulator of the LytR AlgR family
HT750_RS22120	COG3275	phosphorelay sensor kinase activity
HT750_RS22125	COG0436	Aminotransferase
HT750_RS22135	COG1560	Kdo2-lipid A biosynthetic process
HT750_RS22160	COG0028	Belongs to the TPP enzyme family
HT750_RS22165	COG0679	Auxin Efflux Carrier
HT750_RS22170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HT750_RS22175	COG2198	Histidine kinase
HT750_RS22175	COG2205	protein histidine kinase activity
HT750_RS22175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS22175	COG0784	Response regulator, receiver
HT750_RS22180	COG2197	response regulator
HT750_RS22185	COG1566	PFAM secretion protein HlyD family protein
HT750_RS22190	COG0477	Major facilitator Superfamily
HT750_RS22200	COG2610	gluconate transmembrane transporter activity
HT750_RS22205	COG0583	DNA-binding transcription factor activity
HT750_RS22210	COG0582	viral genome integration into host DNA
HT750_RS22215	COG0582	viral genome integration into host DNA
HT750_RS22400	COG3772	lysozyme
HT750_RS22425	COG5484	DNA packaging
HT750_RS22425	COG3728	DNA packaging
HT750_RS22430	COG1783	phage Terminase large subunit
HT750_RS22525	COG1185	polyribonucleotide nucleotidyltransferase activity
HT750_RS22570	COG0582	viral genome integration into host DNA
HT750_RS22580	COG2116	formate transmembrane transporter activity
HT750_RS22585	COG2853	Lipoprotein
HT750_RS22595	COG2067	long-chain fatty acid transport protein
HT750_RS22600	COG3691	Protein conserved in bacteria
HT750_RS22615	COG2062	phosphohistidine phosphatase, SixA
HT750_RS22620	COG3539	Fimbrial protein
HT750_RS22625	COG3188	usher protein
HT750_RS22630	COG3121	Chaperone
HT750_RS22635	COG3539	Fimbrial protein
HT750_RS22640	COG3539	Fimbrial protein
HT750_RS22645	COG3539	Fimbrial protein
HT750_RS22670	COG2890	protein-(glutamine-N5) methyltransferase activity
HT750_RS22685	COG0730	response to heat
HT750_RS22690	COG3101	peptidyl-lysine hydroxylation
HT750_RS22705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT750_RS22710	COG2814	Major facilitator Superfamily
HT750_RS22725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HT750_RS22735	COG0586	Pfam SNARE associated Golgi protein
HT750_RS22745	COG0285	dihydrofolate synthase activity
HT750_RS22750	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HT750_RS22755	COG1286	toxin biosynthetic process
HT750_RS22760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HT750_RS22765	COG0163	prenyltransferase activity
HT750_RS22770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS22775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT750_RS22780	COG4215	(ABC) transporter
HT750_RS22785	COG4160	amino acid transport
HT750_RS22790	COG4598	ABC transporter
HT750_RS22795	COG5464	transposase or invertase
HT750_RS22800	COG0626	cystathionine gamma-synthase activity
HT750_RS22805	COG1757	Na H antiporter
HT750_RS22810	COG1090	epimerase
HT750_RS22815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HT750_RS22820	COG0625	glutathione transferase activity
HT750_RS22825	COG0625	glutathione transferase activity
HT750_RS22830	COG0622	Phosphoesterase
HT750_RS22835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HT750_RS22840	COG1288	antiporter activity
HT750_RS22845	COG0857	belongs to the CobB CobQ family
HT750_RS22845	COG0280	phosphate acetyltransferase
HT750_RS22850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HT750_RS22865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT750_RS22870	COG0490	domain, Protein
HT750_RS22870	COG0471	metal ion transport
HT750_RS22880	COG0436	Aminotransferase
HT750_RS22885	COG0583	DNA-binding transcription factor activity
HT750_RS22905	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HT750_RS22910	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HT750_RS22915	COG1034	ATP synthesis coupled electron transport
HT750_RS22930	COG0839	Belongs to the complex I subunit 6 family
HT750_RS22940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HT750_RS22945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HT750_RS22975	COG2153	protein acetylation
HT750_RS22980	COG4575	ribosome binding
HT750_RS22985	COG1169	isochorismate synthase
HT750_RS23000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HT750_RS23010	COG0318	PFAM AMP-dependent synthetase and ligase
HT750_RS23075	COG1414	Transcriptional regulator
HT750_RS23085	COG2271	Major facilitator Superfamily
HT750_RS23100	COG5464	transposase or invertase
HT750_RS23105	COG0247	lactate metabolic process
HT750_RS23115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HT750_RS23120	COG2271	Major facilitator Superfamily
HT750_RS23125	COG0584	glycerophosphoryl diester phosphodiesterase
HT750_RS23130	COG0583	DNA-binding transcription factor activity
HT750_RS23135	COG2814	Major facilitator Superfamily
HT750_RS23140	COG3642	lipopolysaccharide core region biosynthetic process
HT750_RS23145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HT750_RS23150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT750_RS23155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT750_RS23160	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS23170	COG1802	Transcriptional regulator
HT750_RS23180	COG4948	Mandelate Racemase Muconate Lactonizing
HT750_RS23185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HT750_RS23190	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HT750_RS23195	COG3234	Protein of unknown function (DUF1175)
HT750_RS23200	COG2373	Large extracellular alpha-helical protein
HT750_RS23205	COG5445	Predicted secreted protein (DUF2300)
HT750_RS23210	COG4676	Protein conserved in bacteria
HT750_RS23215	COG0183	Belongs to the thiolase family
HT750_RS23220	COG2031	fatty acid transporter
HT750_RS23225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HT750_RS23230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HT750_RS23235	COG2204	response regulator
HT750_RS23240	COG3852	Histidine kinase
HT750_RS23245	COG0784	Response regulator, receiver
HT750_RS23245	COG2205	protein histidine kinase activity
HT750_RS23250	COG2197	response regulator
HT750_RS23255	COG0642	Histidine kinase
HT750_RS23255	COG2198	Histidine kinase
HT750_RS23260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HT750_RS23265	COG1477	protein flavinylation
HT750_RS23270	COG2169	Transcriptional regulator
HT750_RS23270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HT750_RS23275	COG3145	DNA-N1-methyladenine dioxygenase activity
HT750_RS23280	COG4615	Cyclic peptide transporter
HT750_RS23295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS23295	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HT750_RS23300	COG3062	negative regulation of establishment of protein localization
HT750_RS23310	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS23315	COG0348	domain, Protein
HT750_RS23320	COG3043	anaerobic respiration
HT750_RS23325	COG3005	denitrification pathway
HT750_RS23330	COG4133	protoheme IX ABC transporter activity
HT750_RS23335	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT750_RS23340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT750_RS23345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT750_RS23355	COG1138	Cytochrome C-type biogenesis protein
HT750_RS23360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT750_RS23365	COG3088	subunit of a heme lyase
HT750_RS23365	COG4235	cytochrome complex assembly
HT750_RS23370	COG2197	response regulator
HT750_RS23375	COG3468	outer membrane autotransporter barrel domain protein
HT750_RS23385	COG3083	sulfuric ester hydrolase activity
HT750_RS23405	COG1061	Type III restriction enzyme res subunit
HT750_RS23410	COG1187	pseudouridine synthase activity
HT750_RS23415	COG2814	Major facilitator Superfamily
HT750_RS23425	COG4172	Belongs to the ABC transporter superfamily
HT750_RS23430	COG4239	(ABC) transporter, permease
HT750_RS23435	COG4174	ABC transporter (Permease)
HT750_RS23440	COG4166	transmembrane transport
HT750_RS23445	COG2200	EAL domain
HT750_RS23450	COG0791	NLP P60 protein
HT750_RS23455	COG0671	phosphoesterase, PA-phosphatase related
HT750_RS23460	COG0523	cobalamin synthesis protein
HT750_RS23465	COG0246	Mannitol dehydrogenase
HT750_RS23480	COG2814	Major facilitator Superfamily
HT750_RS23485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS23485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT750_RS23490	COG1105	Belongs to the carbohydrate kinase PfkB family
HT750_RS23495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HT750_RS23495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS23495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT750_RS23500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS23505	COG2313	pseudouridylate synthase activity
HT750_RS23510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT750_RS23515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT750_RS23525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT750_RS23530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT750_RS23530	COG1522	sequence-specific DNA binding
HT750_RS23540	COG2855	membrane
HT750_RS23545	COG0583	DNA-binding transcription factor activity
HT750_RS23550	COG0833	amino acid
HT750_RS23555	COG4771	TonB-dependent receptor
HT750_RS23565	COG0560	Phosphoserine phosphatase
HT750_RS23570	COG1760	l-serine dehydratase
HT750_RS23590	COG2311	Membrane
HT750_RS23595	COG1609	Transcriptional regulator
HT750_RS23600	COG1879	ABC-type sugar transport system periplasmic component
HT750_RS23610	COG4211	Belongs to the binding-protein-dependent transport system permease family
HT750_RS23615	COG0167	dihydroorotate dehydrogenase activity
HT750_RS23615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HT750_RS23620	COG0493	'glutamate synthase
HT750_RS23630	COG2949	membrane
HT750_RS23640	COG1346	cytolysis
HT750_RS23650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT750_RS23660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HT750_RS23665	COG3593	DNA synthesis involved in DNA repair
HT750_RS23670	COG2990	Protein conserved in bacteria
HT750_RS23675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT750_RS23680	COG0577	efflux transmembrane transporter activity
HT750_RS23680	COG1136	(ABC) transporter
HT750_RS23685	COG1278	Cold shock
HT750_RS23695	COG0542	response to heat
HT750_RS23715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HT750_RS23720	COG4988	ABC transporter
HT750_RS23725	COG0492	ferredoxin-NADP+ reductase activity
HT750_RS23730	COG1522	sequence-specific DNA binding
HT750_RS23745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HT750_RS23755	COG0243	molybdopterin cofactor binding
HT750_RS23760	COG0437	4 iron, 4 sulfur cluster binding
HT750_RS23765	COG3302	dmso reductase anchor subunit
HT750_RS23770	COG1335	isochorismatase
HT750_RS23780	COG0531	amino acid
HT750_RS23785	COG0583	DNA-binding transcription factor activity
HT750_RS23790	COG2249	NAD(P)H dehydrogenase (quinone) activity
HT750_RS23795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HT750_RS23800	COG4974	Belongs to the 'phage' integrase family