locus-tag	class	description
RG60_RS00025	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS00120	COG2831	hemolysin activation secretion protein
RG60_RS00125	COG2994	toxin metabolic process
RG60_RS00130	COG3210	domain, Protein
RG60_RS00175	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
RG60_RS00180	COG3969	phosphoadenosine phosphosulfate
RG60_RS00185	COG1475	DNA binding
RG60_RS00205	COG1201	RNA secondary structure unwinding
RG60_RS00230	COG2194	sulfuric ester hydrolase activity
RG60_RS00235	COG0582	viral genome integration into host DNA
RG60_RS00250	COG0305	Participates in initiation and elongation during chromosome replication
RG60_RS00290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG60_RS00440	COG2207	Transcriptional regulator
RG60_RS00440	COG3708	Transcriptional regulator
RG60_RS00445	COG2831	hemolysin activation secretion protein
RG60_RS00450	COG3210	domain, Protein
RG60_RS00490	COG3210	domain, Protein
RG60_RS00510	COG3328	transposase activity
RG60_RS00540	COG4221	oxidoreductase activity
RG60_RS00590	COG0318	PFAM AMP-dependent synthetase and ligase
RG60_RS00590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG60_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS00590	COG3321	synthase
RG60_RS00590	COG0300	oxidoreductase activity
RG60_RS00595	COG3787	Belongs to the UPF0306 family
RG60_RS00690	COG1811	Na channel or pump
RG60_RS00700	COG1982	Orn Lys Arg decarboxylase major
RG60_RS00705	COG2211	Major facilitator Superfamily
RG60_RS00720	COG1194	a g-specific adenine glycosylase
RG60_RS00735	COG3171	Protein conserved in bacteria
RG60_RS00745	COG0252	asparaginase activity
RG60_RS00760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG60_RS00765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG60_RS00770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG60_RS00785	COG0762	integral membrane protein
RG60_RS00790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RG60_RS00795	COG2805	Type II/IV secretion system protein
RG60_RS00810	COG0189	ligase activity
RG60_RS00815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RG60_RS00820	COG2356	endonuclease I
RG60_RS00830	COG2814	Major facilitator Superfamily
RG60_RS00860	COG1166	arginine decarboxylase activity
RG60_RS00875	COG0501	Belongs to the peptidase M48B family
RG60_RS00880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG60_RS00885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS00890	COG2213	PTS system mannitol-specific
RG60_RS00895	COG1063	alcohol dehydrogenase
RG60_RS00900	COG1494	fructose-1,6-bisphosphatase
RG60_RS00910	COG1072	(Pantothenic acid kinase))
RG60_RS00915	COG1122	ATPase activity
RG60_RS00920	COG1122	ATPase activity
RG60_RS00955	COG0191	fructose-bisphosphate aldolase activity
RG60_RS00970	COG0668	transmembrane transport
RG60_RS00980	COG2968	Membrane
RG60_RS00985	COG0583	DNA-binding transcription factor activity
RG60_RS00990	COG0427	acetyl-CoA hydrolase
RG60_RS00995	COG1024	Enoyl-CoA hydratase
RG60_RS01000	COG1703	isobutyryl-CoA mutase activity
RG60_RS01005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG60_RS01005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG60_RS01030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RG60_RS01055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RG60_RS01080	COG0006	proline dipeptidase activity
RG60_RS01085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG60_RS01090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG60_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS01115	COG2723	6-phospho-beta-galactosidase activity
RG60_RS01125	COG1272	protein, Hemolysin III
RG60_RS01135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RG60_RS01145	COG0716	FMN binding
RG60_RS01150	COG4974	Belongs to the 'phage' integrase family
RG60_RS01155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG60_RS01160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RG60_RS01185	COG2233	PERMEase
RG60_RS01195	COG0493	'glutamate synthase
RG60_RS01195	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS01200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS01205	COG2252	PERMEase
RG60_RS01210	COG0402	S-adenosylhomocysteine deaminase activity
RG60_RS01215	COG2233	PERMEase
RG60_RS01220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG60_RS01220	COG2080	2 iron, 2 sulfur cluster binding
RG60_RS01225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG60_RS01230	COG0402	S-adenosylhomocysteine deaminase activity
RG60_RS01235	COG0493	'glutamate synthase
RG60_RS01235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS01240	COG2068	MobA-Related Protein
RG60_RS01245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG60_RS01250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG60_RS01250	COG3608	succinylglutamate desuccinylase aspartoacylase
RG60_RS01255	COG0549	Belongs to the carbamate kinase family
RG60_RS01265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG60_RS01270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG60_RS01275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RG60_RS01280	COG3829	transcription factor binding
RG60_RS01285	COG2080	2 iron, 2 sulfur cluster binding
RG60_RS01290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG60_RS01295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG60_RS01305	COG4942	peptidase
RG60_RS01390	COG3387	PFAM Glycoside hydrolase 15-related
RG60_RS01475	COG2197	response regulator
RG60_RS01480	COG2197	response regulator
RG60_RS01495	COG3710	Transcriptional regulator
RG60_RS01495	COG0457	Tetratricopeptide repeat
RG60_RS01505	COG0457	Tetratricopeptide repeat
RG60_RS01530	COG3710	Transcriptional regulator
RG60_RS01535	COG2771	luxR family
RG60_RS01540	COG0814	amino acid
RG60_RS01545	COG0183	Belongs to the thiolase family
RG60_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS01560	COG2814	Major facilitator Superfamily
RG60_RS01565	COG1794	racemase activity, acting on amino acids and derivatives
RG60_RS01570	COG0583	DNA-binding transcription factor activity
RG60_RS01580	COG1609	Transcriptional regulator
RG60_RS01600	COG0667	Aldo Keto reductase
RG60_RS01610	COG0861	Integral membrane protein TerC family
RG60_RS01635	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
RG60_RS01650	COG2165	general secretion pathway protein
RG60_RS01655	COG4795	General secretion pathway protein
RG60_RS01665	COG4967	type IV pilus modification protein PilV
RG60_RS01670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RG60_RS01675	COG1025	Belongs to the peptidase M16 family
RG60_RS01680	COG1074	ATP-dependent DNA helicase activity
RG60_RS01685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RG60_RS01690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RG60_RS01690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RG60_RS01695	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG60_RS01720	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RG60_RS01725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RG60_RS01730	COG2166	iron-sulfur cluster assembly
RG60_RS01735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RG60_RS01745	COG0583	DNA-binding transcription factor activity
RG60_RS01750	COG2363	Small membrane protein
RG60_RS01760	COG1349	DNA-binding transcription factor activity
RG60_RS01770	COG1070	Carbohydrate kinase
RG60_RS01780	COG0738	Major facilitator superfamily
RG60_RS01785	COG0235	Class ii aldolase
RG60_RS01790	COG1454	alcohol dehydrogenase
RG60_RS01800	COG1760	l-serine dehydratase
RG60_RS01805	COG0814	amino acid
RG60_RS01810	COG1611	Belongs to the LOG family
RG60_RS01830	COG3098	single-species biofilm formation
RG60_RS01835	COG0564	pseudouridine synthase activity
RG60_RS01840	COG0716	FMN binding
RG60_RS01845	COG2271	Major facilitator Superfamily
RG60_RS01850	COG4948	Mandelate Racemase Muconate Lactonizing
RG60_RS01855	COG4948	Mandelate Racemase Muconate Lactonizing
RG60_RS01860	COG4999	Histidine kinase
RG60_RS01860	COG3850	Histidine kinase
RG60_RS01860	COG3437	response regulator, receiver
RG60_RS01860	COG2205	protein histidine kinase activity
RG60_RS01870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG60_RS01875	COG2336	PFAM SpoVT AbrB
RG60_RS01880	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG60_RS01885	COG3956	TIGRFAM MazG family protein
RG60_RS01905	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG60_RS01915	COG0602	queuosine metabolic process
RG60_RS01920	COG1070	Carbohydrate kinase
RG60_RS01925	COG0720	synthase
RG60_RS01950	COG1203	CRISPR-associated helicase, Cas3
RG60_RS01970	COG1857	crispr-associated protein
RG60_RS01985	COG1518	maintenance of DNA repeat elements
RG60_RS01990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG60_RS01995	COG2234	aminopeptidase activity
RG60_RS02050	COG1388	LysM domain
RG60_RS02050	COG4942	peptidase
RG60_RS02055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG60_RS02080	COG2610	gluconate transmembrane transporter activity
RG60_RS02085	COG3622	Belongs to the hyi family
RG60_RS02090	COG0235	Class ii aldolase
RG60_RS02095	COG3395	kinase activity
RG60_RS02100	COG2084	Dehydrogenase
RG60_RS02105	COG1349	DNA-binding transcription factor activity
RG60_RS02110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG60_RS02125	COG3604	Transcriptional regulator
RG60_RS02130	COG0309	Hydrogenase expression formation protein (HypE)
RG60_RS02135	COG0409	Hydrogenase expression formation protein
RG60_RS02140	COG0298	carbon dioxide binding
RG60_RS02145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RG60_RS02150	COG0375	protein maturation
RG60_RS02165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS02170	COG0651	ATP synthesis coupled electron transport
RG60_RS02175	COG0650	Formate hydrogenlyase subunit 4
RG60_RS02180	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG60_RS02180	COG3261	NADH dehydrogenase
RG60_RS02185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG60_RS02190	COG3260	NADH ubiquinone oxidoreductase 20
RG60_RS02200	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG60_RS02210	COG5499	transcription regulator containing HTH domain
RG60_RS02215	COG2723	6-phospho-beta-galactosidase activity
RG60_RS02220	COG1263	PTS System
RG60_RS02220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS02225	COG1609	Transcriptional regulator
RG60_RS02230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS02235	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RG60_RS02260	COG1349	DNA-binding transcription factor activity
RG60_RS02265	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS02275	COG3731	PTS system glucitol sorbitol-specific IIA component
RG60_RS02280	COG3732	PTS system glucitol sorbitol-specific
RG60_RS02285	COG3730	PTS system glucitol sorbitol-specific
RG60_RS02290	COG2951	lytic endotransglycosylase activity
RG60_RS02295	COG1546	Belongs to the CinA family
RG60_RS02320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RG60_RS02345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG60_RS02350	COG1238	metal cluster binding
RG60_RS02365	COG2814	Major facilitator Superfamily
RG60_RS02370	COG1566	PFAM secretion protein HlyD family protein
RG60_RS02375	COG1846	Transcriptional regulator
RG60_RS02385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RG60_RS02390	COG2814	Major facilitator Superfamily
RG60_RS02400	COG2113	Glycine betaine
RG60_RS02405	COG4176	ABC-type proline glycine betaine transport system permease component
RG60_RS02410	COG4175	Glycine betaine
RG60_RS02415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG60_RS02420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG60_RS02430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG60_RS02435	COG4575	ribosome binding
RG60_RS02450	COG2916	Histone family protein nucleoid-structuring protein H-NS
RG60_RS02455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG60_RS02460	COG0640	Transcriptional regulator
RG60_RS02465	COG0401	homolog of Blt101
RG60_RS02470	COG1652	LysM domain
RG60_RS02475	COG1802	Transcriptional regulator
RG60_RS02480	COG1113	amino acid transport
RG60_RS02485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG60_RS02490	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS02495	COG0579	oxidoreductase
RG60_RS02505	COG0366	Alpha amylase catalytic
RG60_RS02540	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS02555	COG3596	GTP binding
RG60_RS02560	COG3311	Transcriptional regulator
RG60_RS02590	COG0582	viral genome integration into host DNA
RG60_RS02605	COG2867	negative regulation of translational initiation
RG60_RS02615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG60_RS02620	COG0497	DNA recombination
RG60_RS02640	COG4536	flavin adenine dinucleotide binding
RG60_RS02645	COG4137	Cytochrome C assembly protein
RG60_RS02650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RG60_RS02675	COG2885	chlorophyll binding
RG60_RS02680	COG2199	diguanylate cyclase activity
RG60_RS02695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG60_RS02700	COG0287	Prephenate dehydrogenase
RG60_RS02700	COG1605	Chorismate mutase
RG60_RS02705	COG0077	Prephenate dehydratase
RG60_RS02705	COG1605	Chorismate mutase
RG60_RS02710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG60_RS02720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG60_RS02725	COG0564	pseudouridine synthase activity
RG60_RS02730	COG1496	oxidoreductase activity
RG60_RS02735	COG0542	response to heat
RG60_RS02770	COG0477	Major facilitator Superfamily
RG60_RS02775	COG5544	Lipoprotein
RG60_RS02780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG60_RS02785	COG1042	CoA-binding domain protein
RG60_RS02785	COG0045	succinate-CoA ligase (ADP-forming) activity
RG60_RS02785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG60_RS02790	COG3148	PFAM DTW domain containing protein
RG60_RS02795	COG3118	belongs to the thioredoxin family
RG60_RS02800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG60_RS02820	COG0583	DNA-binding transcription factor activity
RG60_RS02825	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS02830	COG0513	Belongs to the DEAD box helicase family
RG60_RS02840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG60_RS02850	COG1595	DNA-templated transcription, initiation
RG60_RS02855	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RG60_RS02860	COG3026	antisigma factor binding
RG60_RS02865	COG3086	response to oxidative stress
RG60_RS02875	COG0681	Belongs to the peptidase S26 family
RG60_RS02900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RG60_RS02925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS02930	COG1737	Transcriptional regulator
RG60_RS02935	COG0560	Phosphoserine phosphatase
RG60_RS02960	COG2205	protein histidine kinase activity
RG60_RS02965	COG3170	Tfp pilus assembly protein FimV
RG60_RS02970	COG2204	response regulator
RG60_RS02975	COG0347	Belongs to the P(II) protein family
RG60_RS02980	COG1017	nitric oxide dioxygenase activity
RG60_RS02980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG60_RS02995	COG1940	carbohydrate kinase activity
RG60_RS03000	COG0457	Tetratricopeptide repeat
RG60_RS03005	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS03010	COG1129	ABC transporter
RG60_RS03015	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG60_RS03020	COG1063	alcohol dehydrogenase
RG60_RS03025	COG2017	converts alpha-aldose to the beta-anomer
RG60_RS03030	COG2259	Doxx family
RG60_RS03055	COG4638	Rieske (2fe-2S)
RG60_RS03060	COG0583	DNA-binding transcription factor activity
RG60_RS03065	COG2814	Major facilitator Superfamily
RG60_RS03070	COG3711	transcriptional antiterminator
RG60_RS03075	COG1073	alpha beta
RG60_RS03080	COG0483	inositol monophosphate 1-phosphatase activity
RG60_RS03100	COG0822	iron-sulfur transferase activity
RG60_RS03120	COG0633	Ferredoxin
RG60_RS03125	COG2975	iron-sulfur cluster assembly
RG60_RS03140	COG2897	thiosulfate sulfurtransferase activity
RG60_RS03145	COG2373	Large extracellular alpha-helical protein
RG60_RS03150	COG4953	penicillin-binding protein 1C
RG60_RS03180	COG2976	Protein conserved in bacteria
RG60_RS03195	COG1645	bacterial-type flagellum-dependent swarming motility
RG60_RS03205	COG0517	IMP dehydrogenase activity
RG60_RS03205	COG0516	GMP reductase activity
RG60_RS03220	COG3133	Outer membrane lipoprotein
RG60_RS03240	COG2200	EAL domain
RG60_RS03245	COG0248	Ppx GppA phosphatase
RG60_RS03250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RG60_RS03255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RG60_RS03275	COG2233	PERMEase
RG60_RS03285	COG1393	Belongs to the ArsC family
RG60_RS03290	COG4783	chaperone-mediated protein folding
RG60_RS03295	COG0628	permease
RG60_RS03300	COG2116	formate transmembrane transporter activity
RG60_RS03305	COG2116	formate transmembrane transporter activity
RG60_RS03310	COG3604	Transcriptional regulator
RG60_RS03320	COG3260	NADH ubiquinone oxidoreductase 20
RG60_RS03325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG60_RS03330	COG3261	NADH dehydrogenase
RG60_RS03330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG60_RS03335	COG0651	ATP synthesis coupled electron transport
RG60_RS03340	COG4237	Hydrogenase 4 membrane
RG60_RS03350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG60_RS03355	COG0650	Formate hydrogenlyase subunit 4
RG60_RS03360	COG0651	ATP synthesis coupled electron transport
RG60_RS03365	COG0651	ATP synthesis coupled electron transport
RG60_RS03370	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS03375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RG60_RS03380	COG2716	regulation of RNA biosynthetic process
RG60_RS03390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RG60_RS03425	COG0400	carboxylic ester hydrolase activity
RG60_RS03440	COG1393	Belongs to the ArsC family
RG60_RS03450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG60_RS03455	COG3850	Histidine kinase
RG60_RS03460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS03460	COG0493	'glutamate synthase
RG60_RS03470	COG5342	invasion associated locus B
RG60_RS03475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG60_RS03480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG60_RS03485	COG0281	malic enzyme
RG60_RS03485	COG0280	phosphate acetyltransferase
RG60_RS03490	COG4810	utilization protein
RG60_RS03495	COG4917	ethanolamine utilization protein
RG60_RS03500	COG4766	ethanolamine catabolic process
RG60_RS03505	COG4812	Cobalamin adenosyltransferase
RG60_RS03510	COG0280	phosphate acetyltransferase
RG60_RS03515	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG60_RS03520	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RG60_RS03525	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS03530	COG4820	ethanolamine utilization protein (EutJ)
RG60_RS03535	COG1454	alcohol dehydrogenase
RG60_RS03540	COG3192	ethanolamine utilization protein
RG60_RS03545	COG4819	ethanolamine utilization protein
RG60_RS03550	COG4303	Ethanolamine ammonia lyase large subunit
RG60_RS03560	COG4816	utilization protein
RG60_RS03565	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG60_RS03570	COG2207	Transcriptional regulator
RG60_RS03580	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG60_RS03600	COG2837	iron assimilation
RG60_RS03605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG60_RS03610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS03610	COG1263	PTS System
RG60_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS03630	COG4150	thiosulfate binding
RG60_RS03635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RG60_RS03640	COG4208	sulfate ABC transporter
RG60_RS03645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RG60_RS03650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG60_RS03665	COG2190	(PTS) system
RG60_RS03670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG60_RS03675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS03680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG60_RS03705	COG3530	Putative quorum-sensing-regulated virulence factor
RG60_RS03710	COG0385	Bile acid
RG60_RS03715	COG0583	DNA-binding transcription factor activity
RG60_RS03750	COG3415	Transposase
RG60_RS03755	COG3415	Transposase
RG60_RS03770	COG2199	diguanylate cyclase activity
RG60_RS03770	COG2200	EAL domain
RG60_RS03775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG60_RS03805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS03810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS03815	COG0006	proline dipeptidase activity
RG60_RS03820	COG1363	Peptidase, m42
RG60_RS03830	COG2207	Transcriptional regulator
RG60_RS03835	COG3279	Response regulator of the LytR AlgR family
RG60_RS03840	COG3275	phosphorelay sensor kinase activity
RG60_RS03845	COG0436	Aminotransferase
RG60_RS03855	COG1560	Kdo2-lipid A biosynthetic process
RG60_RS03885	COG0028	Belongs to the TPP enzyme family
RG60_RS03890	COG0679	Auxin Efflux Carrier
RG60_RS03895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RG60_RS03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS03900	COG2198	Histidine kinase
RG60_RS03900	COG2205	protein histidine kinase activity
RG60_RS03900	COG0784	Response regulator, receiver
RG60_RS03905	COG2197	response regulator
RG60_RS03910	COG1566	PFAM secretion protein HlyD family protein
RG60_RS03915	COG0477	Major facilitator Superfamily
RG60_RS03925	COG2610	gluconate transmembrane transporter activity
RG60_RS03960	COG2116	formate transmembrane transporter activity
RG60_RS03965	COG2853	Lipoprotein
RG60_RS03980	COG2067	long-chain fatty acid transport protein
RG60_RS03990	COG3691	Protein conserved in bacteria
RG60_RS04005	COG2062	phosphohistidine phosphatase, SixA
RG60_RS04010	COG3539	Fimbrial protein
RG60_RS04015	COG3188	usher protein
RG60_RS04020	COG3121	Chaperone
RG60_RS04025	COG3539	Fimbrial protein
RG60_RS04030	COG3539	Fimbrial protein
RG60_RS04035	COG3539	Fimbrial protein
RG60_RS04065	COG0730	response to heat
RG60_RS04070	COG3101	peptidyl-lysine hydroxylation
RG60_RS04085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG60_RS04095	COG2814	Major facilitator Superfamily
RG60_RS04165	COG0859	PFAM glycosyl transferase family 9
RG60_RS04170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG60_RS04175	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG60_RS04175	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG60_RS04260	COG4695	Portal protein
RG60_RS04350	COG4974	Belongs to the 'phage' integrase family
RG60_RS04360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG60_RS04370	COG0586	Pfam SNARE associated Golgi protein
RG60_RS04380	COG0285	dihydrofolate synthase activity
RG60_RS04385	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RG60_RS04395	COG1286	toxin biosynthetic process
RG60_RS04400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RG60_RS04405	COG0163	prenyltransferase activity
RG60_RS04410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS04415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS04420	COG4215	(ABC) transporter
RG60_RS04425	COG4160	amino acid transport
RG60_RS04430	COG4598	ABC transporter
RG60_RS04435	COG5464	transposase or invertase
RG60_RS04440	COG1090	epimerase
RG60_RS04445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG60_RS04450	COG0625	glutathione transferase activity
RG60_RS04455	COG0625	glutathione transferase activity
RG60_RS04460	COG0622	Phosphoesterase
RG60_RS04465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RG60_RS04470	COG1288	antiporter activity
RG60_RS04475	COG0857	belongs to the CobB CobQ family
RG60_RS04475	COG0280	phosphate acetyltransferase
RG60_RS04480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG60_RS04500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG60_RS04505	COG0471	metal ion transport
RG60_RS04505	COG0490	domain, Protein
RG60_RS04515	COG0436	Aminotransferase
RG60_RS04525	COG0583	DNA-binding transcription factor activity
RG60_RS04545	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RG60_RS04550	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RG60_RS04555	COG1034	ATP synthesis coupled electron transport
RG60_RS04570	COG0839	Belongs to the complex I subunit 6 family
RG60_RS04580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG60_RS04585	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG60_RS04615	COG2153	protein acetylation
RG60_RS04620	COG4575	ribosome binding
RG60_RS04625	COG1169	isochorismate synthase
RG60_RS04640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RG60_RS04650	COG0318	PFAM AMP-dependent synthetase and ligase
RG60_RS04720	COG5464	transposase or invertase
RG60_RS04725	COG0247	lactate metabolic process
RG60_RS04735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG60_RS04740	COG2271	Major facilitator Superfamily
RG60_RS04745	COG0584	glycerophosphoryl diester phosphodiesterase
RG60_RS04750	COG0583	DNA-binding transcription factor activity
RG60_RS04760	COG3642	lipopolysaccharide core region biosynthetic process
RG60_RS04765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG60_RS04770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG60_RS04775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG60_RS04785	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS04795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG60_RS04800	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RG60_RS04805	COG3234	Protein of unknown function (DUF1175)
RG60_RS04810	COG2373	Large extracellular alpha-helical protein
RG60_RS04815	COG5445	Predicted secreted protein (DUF2300)
RG60_RS04820	COG4676	Protein conserved in bacteria
RG60_RS04825	COG0183	Belongs to the thiolase family
RG60_RS04830	COG2031	fatty acid transporter
RG60_RS04835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RG60_RS04840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RG60_RS04845	COG2204	response regulator
RG60_RS04850	COG3852	Histidine kinase
RG60_RS04855	COG0784	Response regulator, receiver
RG60_RS04855	COG2205	protein histidine kinase activity
RG60_RS04865	COG2197	response regulator
RG60_RS04870	COG2198	Histidine kinase
RG60_RS04870	COG0642	Histidine kinase
RG60_RS04890	COG1477	protein flavinylation
RG60_RS04895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG60_RS04895	COG2169	Transcriptional regulator
RG60_RS04900	COG3145	DNA-N1-methyladenine dioxygenase activity
RG60_RS04905	COG4615	Cyclic peptide transporter
RG60_RS04925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS04925	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS04930	COG3062	negative regulation of establishment of protein localization
RG60_RS04940	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS04945	COG0348	domain, Protein
RG60_RS04950	COG3043	anaerobic respiration
RG60_RS04955	COG3005	denitrification pathway
RG60_RS04965	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG60_RS04970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG60_RS04975	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG60_RS04985	COG1138	Cytochrome C-type biogenesis protein
RG60_RS04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RG60_RS04995	COG4235	cytochrome complex assembly
RG60_RS04995	COG3088	subunit of a heme lyase
RG60_RS05000	COG2197	response regulator
RG60_RS05010	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS05015	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS05025	COG3083	sulfuric ester hydrolase activity
RG60_RS05045	COG1061	Type III restriction enzyme res subunit
RG60_RS05055	COG1187	pseudouridine synthase activity
RG60_RS05060	COG2814	Major facilitator Superfamily
RG60_RS05075	COG4172	Belongs to the ABC transporter superfamily
RG60_RS05080	COG4239	(ABC) transporter, permease
RG60_RS05085	COG4174	ABC transporter (Permease)
RG60_RS05090	COG4166	transmembrane transport
RG60_RS05095	COG2200	EAL domain
RG60_RS05100	COG0791	NLP P60 protein
RG60_RS05105	COG0671	phosphoesterase, PA-phosphatase related
RG60_RS05110	COG0523	cobalamin synthesis protein
RG60_RS05115	COG0246	Mannitol dehydrogenase
RG60_RS05130	COG2814	Major facilitator Superfamily
RG60_RS05135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS05135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS05140	COG1105	Belongs to the carbohydrate kinase PfkB family
RG60_RS05145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RG60_RS05145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS05145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS05150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG60_RS05155	COG2313	pseudouridylate synthase activity
RG60_RS05160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG60_RS05165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG60_RS05175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG60_RS05180	COG1522	sequence-specific DNA binding
RG60_RS05180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG60_RS05190	COG2855	membrane
RG60_RS05195	COG0583	DNA-binding transcription factor activity
RG60_RS05205	COG0833	amino acid
RG60_RS05215	COG4771	TonB-dependent receptor
RG60_RS05235	COG2311	Membrane
RG60_RS05245	COG1609	Transcriptional regulator
RG60_RS05250	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS05255	COG1129	ABC transporter
RG60_RS05260	COG4211	Belongs to the binding-protein-dependent transport system permease family
RG60_RS05265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RG60_RS05265	COG0167	dihydroorotate dehydrogenase activity
RG60_RS05270	COG0493	'glutamate synthase
RG60_RS05280	COG2949	membrane
RG60_RS05290	COG1346	cytolysis
RG60_RS05300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG60_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS05330	COG0586	Pfam SNARE associated Golgi protein
RG60_RS05340	COG1686	Belongs to the peptidase S11 family
RG60_RS05345	COG0277	FAD linked oxidase domain protein
RG60_RS05350	COG1472	Belongs to the glycosyl hydrolase 3 family
RG60_RS05355	COG1732	Glycine betaine
RG60_RS05360	COG1174	glycine betaine transport
RG60_RS05365	COG1125	glycine betaine transport
RG60_RS05370	COG1174	glycine betaine transport
RG60_RS05380	COG0789	Transcriptional regulator
RG60_RS05385	COG3275	phosphorelay sensor kinase activity
RG60_RS05390	COG3279	Response regulator of the LytR AlgR family
RG60_RS05395	COG4807	Protein conserved in bacteria
RG60_RS05400	COG4808	Protein conserved in bacteria
RG60_RS05405	COG4715	Zinc finger, swim domain protein
RG60_RS05410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RG60_RS05415	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RG60_RS05420	COG0714	Associated with various cellular activities
RG60_RS05445	COG3831	ATPase activity
RG60_RS05455	COG0489	protein tyrosine kinase activity
RG60_RS05470	COG3539	Fimbrial protein
RG60_RS05475	COG3121	Chaperone
RG60_RS05480	COG3188	usher protein
RG60_RS05485	COG3539	Fimbrial protein
RG60_RS05490	COG5455	response to cobalt ion
RG60_RS05510	COG0351	phosphomethylpyrimidine kinase
RG60_RS05515	COG3757	hydrolase, family 25
RG60_RS05520	COG2188	Transcriptional regulator
RG60_RS05525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG60_RS05530	COG1397	ADP-ribosylglycohydrolase
RG60_RS05535	COG2211	Major facilitator Superfamily
RG60_RS05540	COG1830	Aldolase
RG60_RS05545	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS05565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS05570	COG3414	Phosphotransferase system galactitol-specific IIB component
RG60_RS05575	COG3775	system Galactitol-specific IIC component
RG60_RS05580	COG1063	alcohol dehydrogenase
RG60_RS05605	COG0826	peptidase U32
RG60_RS05615	COG3609	addiction module antidote protein, CC2985 family
RG60_RS05630	COG0745	RESPONSE REGULATOR receiver
RG60_RS05635	COG2205	protein histidine kinase activity
RG60_RS05670	COG4245	von Willebrand factor, type A
RG60_RS05675	COG0631	protein serine/threonine phosphatase activity
RG60_RS05680	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
RG60_RS05685	COG0443	Heat shock 70 kDa protein
RG60_RS05690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RG60_RS05695	COG3447	MASE1 domain protein
RG60_RS05695	COG5001	Diguanylate cyclase
RG60_RS05695	COG5002	protein histidine kinase activity
RG60_RS05700	COG0572	uridine kinase
RG60_RS05710	COG2982	Protein involved in outer membrane biogenesis
RG60_RS05720	COG1253	flavin adenine dinucleotide binding
RG60_RS05725	COG1596	polysaccharide export
RG60_RS05730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG60_RS05735	COG3206	protein involved in exopolysaccharide biosynthesis
RG60_RS05735	COG0489	protein tyrosine kinase activity
RG60_RS05740	COG0463	Glycosyl transferase, family 2
RG60_RS05745	COG1045	serine acetyltransferase
RG60_RS05750	COG0438	transferase activity, transferring glycosyl groups
RG60_RS05760	COG1216	Glycosyl transferase, family 2
RG60_RS05765	COG0110	maltose O-acetyltransferase activity
RG60_RS05770	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RG60_RS05775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG60_RS05780	COG1051	belongs to the nudix hydrolase family
RG60_RS05785	COG0297	glycogen (starch) synthase activity
RG60_RS05790	COG0662	Cupin 2, conserved barrel domain protein
RG60_RS05790	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RG60_RS05795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RG60_RS05800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RG60_RS05805	COG2244	polysaccharide biosynthetic process
RG60_RS05810	COG2327	Polysaccharide pyruvyl transferase
RG60_RS05815	COG0438	transferase activity, transferring glycosyl groups
RG60_RS05825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG60_RS05830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG60_RS05850	COG0297	glycogen (starch) synthase activity
RG60_RS05865	COG0438	transferase activity, transferring glycosyl groups
RG60_RS05915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RG60_RS05920	COG0131	Imidazoleglycerol-phosphate dehydratase
RG60_RS05920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG60_RS05930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RG60_RS05950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG60_RS05955	COG0583	DNA-binding transcription factor activity
RG60_RS05960	COG0531	amino acid
RG60_RS05965	COG2391	methyltransferase activity
RG60_RS05970	COG0425	Belongs to the sulfur carrier protein TusA family
RG60_RS05975	COG2925	Exonuclease
RG60_RS05980	COG1686	Belongs to the peptidase S11 family
RG60_RS05990	COG1289	transmembrane transporter activity
RG60_RS05995	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS06000	COG1289	transmembrane transporter activity
RG60_RS06010	COG4917	ethanolamine utilization protein
RG60_RS06015	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RG60_RS06030	COG1376	ErfK ybiS ycfS ynhG family protein
RG60_RS06040	COG0583	DNA-binding transcription factor activity
RG60_RS06045	COG0583	DNA-binding transcription factor activity
RG60_RS06055	COG0534	Mate efflux family protein
RG60_RS06065	COG0217	transcriptional regulatory protein
RG60_RS06070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RG60_RS06075	COG0477	Major facilitator Superfamily
RG60_RS06090	COG2801	Transposase and inactivated derivatives
RG60_RS06095	COG1470	cell adhesion involved in biofilm formation
RG60_RS06095	COG1388	LysM domain
RG60_RS06120	COG3038	cytochrome b561
RG60_RS06125	COG3443	Belongs to the bacterial solute-binding protein 9 family
RG60_RS06140	COG2351	hydroxyisourate hydrolase activity
RG60_RS06145	COG0745	RESPONSE REGULATOR receiver
RG60_RS06150	COG2205	protein histidine kinase activity
RG60_RS06165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG60_RS06180	COG1418	mRNA catabolic process
RG60_RS06185	COG0270	DNA (cytosine-5-)-methyltransferase activity
RG60_RS06190	COG3727	T/G mismatch-specific endonuclease activity
RG60_RS06195	COG0697	spore germination
RG60_RS06200	COG2354	Protein conserved in bacteria
RG60_RS06205	COG5475	Uncharacterized small protein (DUF2158)
RG60_RS06240	COG2197	response regulator
RG60_RS06245	COG1684	flagellar biosynthetic protein fliR
RG60_RS06250	COG1987	bacterial-type flagellum assembly
RG60_RS06255	COG1338	Plays a role in the flagellum-specific transport system
RG60_RS06260	COG3190	flagellar
RG60_RS06265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG60_RS06270	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG60_RS06275	COG1580	Controls the rotational direction of flagella during chemotaxis
RG60_RS06280	COG3144	bacterial-type flagellum assembly
RG60_RS06285	COG2882	bacterial-type flagellum organization
RG60_RS06290	COG1157	protein secretion by the type III secretion system
RG60_RS06295	COG1317	bacterial-type flagellum organization
RG60_RS06300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG60_RS06305	COG1766	The M ring may be actively involved in energy transduction
RG60_RS06320	COG2135	peptidase activity
RG60_RS06325	COG0425	Belongs to the sulfur carrier protein TusA family
RG60_RS06330	COG2391	methyltransferase activity
RG60_RS06345	COG0366	Alpha amylase catalytic
RG60_RS06355	COG1516	flagellar protein fliS
RG60_RS06360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RG60_RS06370	COG1191	sigma factor activity
RG60_RS06380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS06390	COG0765	amino acid transport
RG60_RS06395	COG1126	abc transporter atp-binding protein
RG60_RS06400	COG2197	response regulator
RG60_RS06415	COG2197	response regulator
RG60_RS06540	COG3012	SEC-C Motif Domain Protein
RG60_RS06540	COG3318	Belongs to the UPF0149 family
RG60_RS06545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RG60_RS06570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG60_RS06575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RG60_RS06595	COG3318	Belongs to the UPF0149 family
RG60_RS06595	COG3012	SEC-C Motif Domain Protein
RG60_RS06600	COG0814	amino acid
RG60_RS06610	COG1528	Iron-storage protein
RG60_RS06630	COG1528	Iron-storage protein
RG60_RS06640	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS06645	COG1129	ABC transporter
RG60_RS06650	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG60_RS06655	COG1877	trehalose-phosphatase activity
RG60_RS06665	COG0589	response to stress
RG60_RS06680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RG60_RS06685	COG1360	Flagellar Motor Protein
RG60_RS06690	COG2198	Histidine kinase
RG60_RS06690	COG0643	Histidine kinase
RG60_RS06695	COG0835	chemotaxis
RG60_RS06700	COG0840	transmembrane signaling receptor activity
RG60_RS06705	COG0840	transmembrane signaling receptor activity
RG60_RS06710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RG60_RS06715	COG2201	protein-glutamate methylesterase activity
RG60_RS06720	COG0745	RESPONSE REGULATOR receiver
RG60_RS06725	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RG60_RS06730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG60_RS06735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG60_RS06745	COG3755	Protein conserved in bacteria
RG60_RS06760	COG3102	Protein conserved in bacteria
RG60_RS06770	COG3005	denitrification pathway
RG60_RS06775	COG0243	molybdopterin cofactor binding
RG60_RS06790	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RG60_RS06795	COG1801	Protein of unknown function DUF72
RG60_RS06800	COG1335	isochorismatase
RG60_RS06810	COG0494	nUDIX hydrolase
RG60_RS06815	COG0217	transcriptional regulatory protein
RG60_RS06845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG60_RS06855	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RG60_RS06860	COG0739	heme binding
RG60_RS06865	COG1560	Kdo2-lipid A biosynthetic process
RG60_RS06885	COG3842	ATPase activity
RG60_RS06895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RG60_RS06905	COG2182	Extracellular solute-binding protein
RG60_RS06910	COG1175	transmembrane transport
RG60_RS06915	COG3833	ABC-type maltose transport systems, permease component
RG60_RS06940	COG0469	pyruvate kinase activity
RG60_RS06945	COG1737	Transcriptional regulator
RG60_RS06960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RG60_RS06965	COG0129	dihydroxy-acid dehydratase activity
RG60_RS06970	COG0800	Aldolase
RG60_RS06980	COG3141	response to X-ray
RG60_RS07000	COG2979	Protein of unknown function (DUF533)
RG60_RS07010	COG1770	oligopeptidase
RG60_RS07015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG60_RS07020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG60_RS07030	COG2372	response to copper ion
RG60_RS07035	COG1276	copper resistance
RG60_RS07050	COG0582	viral genome integration into host DNA
RG60_RS07070	COG3723	Recombinational DNA repair protein, rece pathway
RG60_RS07075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG60_RS07125	COG3756	Protein conserved in bacteria
RG60_RS07130	COG1484	DNA-dependent DNA replication
RG60_RS07135	COG1846	Transcriptional regulator
RG60_RS07265	COG3772	lysozyme
RG60_RS07290	COG4220	transposase activity
RG60_RS07360	COG1196	nuclear chromosome segregation
RG60_RS07395	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG60_RS07425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG60_RS07445	COG3008	intermembrane lipid transfer
RG60_RS07450	COG2995	paraquat-inducible protein a
RG60_RS07455	COG1956	GAF domain-containing protein
RG60_RS07465	COG0793	Belongs to the peptidase S41A family
RG60_RS07475	COG2814	Major facilitator Superfamily
RG60_RS07480	COG1414	Transcriptional regulator
RG60_RS07515	COG2226	methyltransferase
RG60_RS07535	COG3716	PTS system mannose fructose sorbose family IID component
RG60_RS07540	COG3715	PTS system
RG60_RS07545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS07545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS07560	COG1253	flavin adenine dinucleotide binding
RG60_RS07565	COG2200	EAL domain
RG60_RS07570	COG1760	l-serine dehydratase
RG60_RS07580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG60_RS07595	COG0251	oxidation-reduction process
RG60_RS07600	COG1199	ATP-dependent helicase activity
RG60_RS07605	COG1214	PFAM Peptidase M22, glycoprotease
RG60_RS07610	COG3065	identical protein binding
RG60_RS07615	COG0318	PFAM AMP-dependent synthetase and ligase
RG60_RS07620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RG60_RS07625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG60_RS07630	COG4638	Rieske (2fe-2S)
RG60_RS07635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG60_RS07640	COG0473	3-isopropylmalate dehydrogenase activity
RG60_RS07645	COG0583	DNA-binding transcription factor activity
RG60_RS07655	COG3615	Tellurite resistance protein tehB
RG60_RS07675	COG0675	Transposase, IS605 OrfB family
RG60_RS07680	COG2261	transglycosylase associated protein
RG60_RS07695	COG2203	Gaf domain
RG60_RS07695	COG2199	diguanylate cyclase activity
RG60_RS07700	COG3042	response to heat
RG60_RS07705	COG3189	MarR family transcriptional regulator
RG60_RS07710	COG2807	transmembrane transport
RG60_RS07715	COG2207	Transcriptional regulator
RG60_RS07730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG60_RS07735	COG2199	diguanylate cyclase activity
RG60_RS07740	COG2199	diguanylate cyclase activity
RG60_RS07750	COG2766	serine protein kinase
RG60_RS07755	COG3713	MltA-interacting MipA family protein
RG60_RS07760	COG0656	L-ascorbic acid biosynthetic process
RG60_RS07765	COG0676	glucose-6-phosphate 1-epimerase activity
RG60_RS07770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG60_RS07780	COG3139	Protein of unknown function (DUF1315)
RG60_RS07785	COG1335	isochorismatase
RG60_RS07790	COG0252	asparaginase activity
RG60_RS07795	COG0616	signal peptide processing
RG60_RS07800	COG0778	Nitroreductase
RG60_RS07815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG60_RS07825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RG60_RS07835	COG0494	nUDIX hydrolase
RG60_RS07840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG60_RS07845	COG2897	thiosulfate sulfurtransferase activity
RG60_RS07850	COG4136	ATPase activity
RG60_RS07855	COG4135	transport system, permease component
RG60_RS07860	COG4134	Bacterial extracellular solute-binding protein
RG60_RS07865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG60_RS07870	COG0398	Pfam SNARE associated Golgi protein
RG60_RS07880	COG0398	Pfam SNARE associated Golgi protein
RG60_RS07885	COG0708	Exodeoxyribonuclease III
RG60_RS07920	COG3678	ATP-independent chaperone mediated protein folding
RG60_RS07930	COG0322	excinuclease ABC activity
RG60_RS07940	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG60_RS07950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG60_RS07955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG60_RS07960	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG60_RS07965	COG1917	Cupin 2, conserved barrel domain protein
RG60_RS07965	COG2169	Transcriptional regulator
RG60_RS07970	COG1486	melibiose metabolic process
RG60_RS08000	COG1823	symporter activity
RG60_RS08005	COG1988	membrane-bound metal-dependent
RG60_RS08010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG60_RS08020	COG3001	Fructosamine kinase
RG60_RS08030	COG1105	Belongs to the carbohydrate kinase PfkB family
RG60_RS08035	COG3137	Salt-induced outer membrane protein
RG60_RS08105	COG0386	Belongs to the glutathione peroxidase family
RG60_RS08115	COG0791	NLP P60 protein
RG60_RS08120	COG2200	EAL domain
RG60_RS08130	COG4256	Hemin uptake protein
RG60_RS08135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG60_RS08145	COG0574	Belongs to the PEP-utilizing enzyme family
RG60_RS08145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG60_RS08150	COG0318	PFAM AMP-dependent synthetase and ligase
RG60_RS08155	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG60_RS08160	COG0644	oxidoreductase
RG60_RS08165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG60_RS08170	COG2086	electron transfer activity
RG60_RS08180	COG1917	Cupin 2, conserved barrel domain protein
RG60_RS08180	COG2207	Transcriptional regulator
RG60_RS08185	COG1960	acyl-CoA dehydrogenase activity
RG60_RS08190	COG4670	ketone body catabolic process
RG60_RS08205	COG2271	Major facilitator Superfamily
RG60_RS08210	COG0738	Major facilitator superfamily
RG60_RS08225	COG0628	permease
RG60_RS08235	COG0247	lactate metabolic process
RG60_RS08235	COG0277	FAD linked oxidase domain protein
RG60_RS08240	COG2050	protein possibly involved in aromatic compounds catabolism
RG60_RS08250	COG0316	Belongs to the HesB IscA family
RG60_RS08255	COG0719	Fe-S assembly protein
RG60_RS08260	COG0396	ATPase activity
RG60_RS08265	COG0719	Fe-S assembly protein
RG60_RS08280	COG1376	ErfK ybiS ycfS ynhG family protein
RG60_RS08285	COG4238	major outer membrane lipoprotein
RG60_RS08290	COG0469	pyruvate kinase activity
RG60_RS08300	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS08305	COG2414	aldehyde ferredoxin oxidoreductase
RG60_RS08315	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS08320	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RG60_RS08330	COG4529	Protein conserved in bacteria
RG60_RS08350	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS08360	COG0307	riboflavin synthase, alpha
RG60_RS08365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RG60_RS08370	COG2814	Major facilitator Superfamily
RG60_RS08375	COG0583	DNA-binding transcription factor activity
RG60_RS08395	COG2814	Major facilitator Superfamily
RG60_RS08400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG60_RS08405	COG0791	NLP P60 protein
RG60_RS08410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RG60_RS08415	COG1201	RNA secondary structure unwinding
RG60_RS08425	COG0346	lactoylglutathione lyase activity
RG60_RS08430	COG1902	pentaerythritol trinitrate reductase activity
RG60_RS08435	COG1309	transcriptional regulator
RG60_RS08440	COG3313	Fe-S protein
RG60_RS08445	COG4989	oxidoreductase activity
RG60_RS08450	COG2032	superoxide dismutase activity
RG60_RS08455	COG1289	transmembrane transporter activity
RG60_RS08460	COG1566	PFAM secretion protein HlyD family protein
RG60_RS08475	COG3133	Outer membrane lipoprotein
RG60_RS08485	COG3895	Periplasmic Protein
RG60_RS08500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RG60_RS08505	COG0625	glutathione transferase activity
RG60_RS08510	COG3104	oligopeptide transport
RG60_RS08520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RG60_RS08530	COG4659	FMN binding
RG60_RS08575	COG0673	inositol 2-dehydrogenase activity
RG60_RS08585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RG60_RS08590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS08590	COG1263	PTS System
RG60_RS08595	COG1609	Transcriptional regulator
RG60_RS08600	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS08605	COG1309	transcriptional regulator
RG60_RS08610	COG3250	beta-galactosidase activity
RG60_RS08625	COG5339	Protein conserved in bacteria
RG60_RS08630	COG1482	cell wall glycoprotein biosynthetic process
RG60_RS08635	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG60_RS08635	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG60_RS08640	COG0114	fumarate hydratase activity
RG60_RS08650	COG2205	protein histidine kinase activity
RG60_RS08655	COG0745	RESPONSE REGULATOR receiver
RG60_RS08660	COG3136	membrane protein required for alginate biosynthesis
RG60_RS08670	COG0531	amino acid
RG60_RS08685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RG60_RS08690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RG60_RS08695	COG0628	permease
RG60_RS08710	COG3591	Belongs to the peptidase S1B family
RG60_RS08730	COG2814	Major facilitator Superfamily
RG60_RS08735	COG0583	DNA-binding transcription factor activity
RG60_RS08740	COG1940	carbohydrate kinase activity
RG60_RS08745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG60_RS08755	COG3381	protein complex oligomerization
RG60_RS08760	COG3302	dmso reductase anchor subunit
RG60_RS08765	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS08770	COG0243	molybdopterin cofactor binding
RG60_RS08775	COG0243	molybdopterin cofactor binding
RG60_RS08790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG60_RS08810	COG4948	Mandelate Racemase Muconate Lactonizing
RG60_RS08815	COG1063	alcohol dehydrogenase
RG60_RS08820	COG0477	Major facilitator Superfamily
RG60_RS08825	COG0246	Mannitol dehydrogenase
RG60_RS08835	COG1802	Transcriptional regulator
RG60_RS08840	COG4221	oxidoreductase activity
RG60_RS08850	COG0339	signal peptide processing
RG60_RS08860	COG1546	Belongs to the CinA family
RG60_RS08865	COG3111	PFAM Bacterial OB fold (BOF) protein
RG60_RS08870	COG3706	GGDEF domain
RG60_RS08880	COG2814	Major facilitator Superfamily
RG60_RS08885	COG0697	spore germination
RG60_RS08890	COG2188	Transcriptional regulator
RG60_RS08900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG60_RS08905	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG60_RS08915	COG2723	6-phospho-beta-galactosidase activity
RG60_RS08925	COG4977	sequence-specific DNA binding
RG60_RS08930	COG1846	Transcriptional regulator
RG60_RS08960	COG0583	DNA-binding transcription factor activity
RG60_RS08965	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS08970	COG2066	Belongs to the glutaminase family
RG60_RS08980	COG2199	diguanylate cyclase activity
RG60_RS09000	COG3781	membrane
RG60_RS09050	COG3210	domain, Protein
RG60_RS09050	COG2911	Protein conserved in bacteria
RG60_RS09060	COG3550	peptidyl-serine autophosphorylation
RG60_RS09060	COG3550	peptidyl-serine autophosphorylation
RG60_RS09115	COG4128	Pfam Zonular occludens toxin
RG60_RS09135	COG4977	sequence-specific DNA binding
RG60_RS09140	COG3188	usher protein
RG60_RS09145	COG3539	Fimbrial protein
RG60_RS09150	COG3539	Fimbrial protein
RG60_RS09155	COG3539	Fimbrial protein
RG60_RS09160	COG0243	molybdopterin cofactor binding
RG60_RS09175	COG3119	arylsulfatase activity
RG60_RS09180	COG0641	radical SAM
RG60_RS09185	COG4178	(ABC) transporter
RG60_RS09190	COG4771	TonB-dependent receptor
RG60_RS09195	COG0612	Peptidase, M16
RG60_RS09205	COG0076	glutamate decarboxylase activity
RG60_RS09210	COG0531	amino acid
RG60_RS09215	COG1649	PFAM Uncharacterised BCR, COG1649
RG60_RS09225	COG2199	diguanylate cyclase activity
RG60_RS09225	COG2200	EAL domain
RG60_RS09225	COG2202	Pas domain
RG60_RS09230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RG60_RS09235	COG0747	negative chemotaxis
RG60_RS09240	COG0601	transmembrane transport
RG60_RS09245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG60_RS09250	COG0444	Belongs to the ABC transporter superfamily
RG60_RS09255	COG4608	Belongs to the ABC transporter superfamily
RG60_RS09260	COG1764	response to oxidative stress
RG60_RS09285	COG1064	alcohol dehydrogenase
RG60_RS09290	COG3093	addiction module antidote protein HigA
RG60_RS09295	COG2864	formate dehydrogenase
RG60_RS09300	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS09310	COG0697	spore germination
RG60_RS09315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG60_RS09320	COG4886	Leucine-rich repeat (LRR) protein
RG60_RS09325	COG2223	nitrite transmembrane transporter activity
RG60_RS09330	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG60_RS09335	COG1140	nitrate reductase beta subunit
RG60_RS09340	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG60_RS09345	COG2181	nitrate reductase activity
RG60_RS09350	COG0384	phenazine biosynthesis protein PhzF
RG60_RS09355	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RG60_RS09360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG60_RS09390	COG3209	COG3209 Rhs family protein
RG60_RS09405	COG0625	glutathione transferase activity
RG60_RS09410	COG1113	amino acid transport
RG60_RS09415	COG3391	amine dehydrogenase activity
RG60_RS09430	COG4772	TonB-dependent receptor
RG60_RS09435	COG1802	Transcriptional regulator
RG60_RS09440	COG2130	NADP-dependent
RG60_RS09450	COG1247	-acetyltransferase
RG60_RS09455	COG3238	Protein conserved in bacteria
RG60_RS09460	COG2963	transposase activity
RG60_RS09465	COG2801	Transposase and inactivated derivatives
RG60_RS09470	COG3238	Protein conserved in bacteria
RG60_RS09505	COG1177	transmembrane transport
RG60_RS09510	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG60_RS09515	COG3842	ATPase activity
RG60_RS09520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG60_RS09525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG60_RS09530	COG1598	PFAM Uncharacterised protein family UPF0150
RG60_RS09545	COG0826	peptidase U32
RG60_RS09550	COG1396	sequence-specific DNA binding
RG60_RS09555	COG3135	benzoate transporter
RG60_RS09560	COG0675	Transposase, IS605 OrfB family
RG60_RS09585	COG0500	methyltransferase
RG60_RS09590	COG1275	C4-dicarboxylate transporter malic acid transport protein
RG60_RS09595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG60_RS09600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG60_RS09605	COG2841	Protein conserved in bacteria
RG60_RS09625	COG5383	Protein conserved in bacteria
RG60_RS09630	COG0583	DNA-binding transcription factor activity
RG60_RS09635	COG0840	transmembrane signaling receptor activity
RG60_RS09650	COG3038	cytochrome b561
RG60_RS09660	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS09665	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG60_RS09670	COG1643	Atp-dependent helicase
RG60_RS09680	COG2453	phosphatase
RG60_RS09680	COG0671	phosphoesterase, PA-phosphatase related
RG60_RS09685	COG2267	carboxylic ester hydrolase activity
RG60_RS09690	COG4589	Belongs to the CDS family
RG60_RS09695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG60_RS09705	COG0667	Aldo Keto reductase
RG60_RS09710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG60_RS09715	COG3327	negative regulation of DNA-templated transcription, initiation
RG60_RS09720	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RG60_RS09725	COG0183	Belongs to the thiolase family
RG60_RS09730	COG2050	protein possibly involved in aromatic compounds catabolism
RG60_RS09735	COG1250	3-hydroxyacyl-CoA dehydrogenase
RG60_RS09740	COG1024	Enoyl-CoA hydratase
RG60_RS09745	COG1024	Enoyl-CoA hydratase
RG60_RS09750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG60_RS09755	COG2151	metal-sulfur cluster biosynthetic enzyme
RG60_RS09760	COG3396	Phenylacetate-CoA oxygenase
RG60_RS09765	COG3460	Phenylacetate-CoA oxygenase
RG60_RS09770	COG3396	Phenylacetate-CoA oxygenase
RG60_RS09775	COG2030	dehydratase
RG60_RS09775	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS09780	COG3733	amine oxidase
RG60_RS09785	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS09790	COG2207	Transcriptional regulator
RG60_RS09795	COG3784	Protein of unknown function (DUF1318)
RG60_RS09805	COG2911	Protein conserved in bacteria
RG60_RS09810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RG60_RS09815	COG3187	Heat shock protein
RG60_RS09820	COG3042	response to heat
RG60_RS09825	COG0674	pyruvate-flavodoxin oxidoreductase activity
RG60_RS09825	COG1013	pyruvate-flavodoxin oxidoreductase activity
RG60_RS09825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG60_RS09825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RG60_RS09830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG60_RS09835	COG0589	response to stress
RG60_RS09845	COG0513	Belongs to the DEAD box helicase family
RG60_RS09860	COG3706	GGDEF domain
RG60_RS09865	COG2840	Smr protein MutS2
RG60_RS09870	COG0583	DNA-binding transcription factor activity
RG60_RS09875	COG1473	amidohydrolase
RG60_RS09880	COG1473	amidohydrolase
RG60_RS09890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RG60_RS09895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG60_RS09900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG60_RS09905	COG0589	response to stress
RG60_RS09910	COG3182	Iron-regulated membrane protein
RG60_RS09915	COG0668	transmembrane transport
RG60_RS09920	COG4166	transmembrane transport
RG60_RS09925	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG60_RS09930	COG0583	DNA-binding transcription factor activity
RG60_RS09935	COG1073	alpha beta
RG60_RS09940	COG1073	alpha beta
RG60_RS09945	COG0702	epimerase
RG60_RS09950	COG2866	Carboxypeptidase
RG60_RS09955	COG4948	Mandelate Racemase Muconate Lactonizing
RG60_RS09960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RG60_RS09965	COG3283	Transcriptional regulator of aromatic amino acids metabolism
RG60_RS09975	COG3106	COG3106 Predicted ATPase
RG60_RS09980	COG1609	Transcriptional regulator
RG60_RS09990	COG3842	ATPase activity
RG60_RS09995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG60_RS10000	COG1554	hydrolase, family 65, central catalytic
RG60_RS10005	COG0673	inositol 2-dehydrogenase activity
RG60_RS10010	COG1082	Xylose isomerase domain protein TIM barrel
RG60_RS10015	COG1063	alcohol dehydrogenase
RG60_RS10020	COG0395	ABC-type sugar transport system, permease component
RG60_RS10025	COG1175	transmembrane transport
RG60_RS10030	COG1653	transport
RG60_RS10035	COG0366	Alpha amylase catalytic
RG60_RS10040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG60_RS10050	COG1983	PspC domain protein
RG60_RS10060	COG1842	Phage shock protein A
RG60_RS10065	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RG60_RS10070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG60_RS10075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RG60_RS10080	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS10090	COG1917	Cupin 2, conserved barrel domain protein
RG60_RS10090	COG1396	sequence-specific DNA binding
RG60_RS10095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RG60_RS10100	COG0174	glutamine synthetase
RG60_RS10105	COG0531	amino acid
RG60_RS10120	COG4166	transmembrane transport
RG60_RS10125	COG4168	peptide transport system, permease
RG60_RS10130	COG4171	peptide transport system, permease
RG60_RS10135	COG4172	Belongs to the ABC transporter superfamily
RG60_RS10140	COG4172	Belongs to the ABC transporter superfamily
RG60_RS10145	COG2852	Protein conserved in bacteria
RG60_RS10150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RG60_RS10155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG60_RS10155	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG60_RS10180	COG1349	DNA-binding transcription factor activity
RG60_RS10190	COG0023	Translation Initiation Factor
RG60_RS10200	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RG60_RS10205	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RG60_RS10210	COG0671	phosphoesterase, PA-phosphatase related
RG60_RS10220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG60_RS10240	COG0583	DNA-binding transcription factor activity
RG60_RS10250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG60_RS10260	COG0616	signal peptide processing
RG60_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS10275	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RG60_RS10280	COG1187	pseudouridine synthase activity
RG60_RS10285	COG0009	L-threonylcarbamoyladenylate synthase
RG60_RS10290	COG0613	PHP domain protein
RG60_RS10300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG60_RS10305	COG0512	Glutamine amidotransferase of anthranilate synthase
RG60_RS10305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG60_RS10310	COG0134	indole-3-glycerol-phosphate synthase activity
RG60_RS10310	COG0135	phosphoribosylanthranilate isomerase activity
RG60_RS10325	COG3729	General stress protein
RG60_RS10330	COG3685	Protein conserved in bacteria
RG60_RS10335	COG3685	Protein conserved in bacteria
RG60_RS10340	COG3047	cAMP biosynthetic process
RG60_RS10355	COG1607	acyl-coa hydrolase
RG60_RS10360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RG60_RS10365	COG2350	Protein conserved in bacteria
RG60_RS10370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG60_RS10390	COG4608	Belongs to the ABC transporter superfamily
RG60_RS10395	COG0444	Belongs to the ABC transporter superfamily
RG60_RS10400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG60_RS10405	COG0601	transmembrane transport
RG60_RS10410	COG4166	transmembrane transport
RG60_RS10420	COG2095	MarC family integral membrane protein
RG60_RS10425	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS10425	COG1454	alcohol dehydrogenase
RG60_RS10430	COG1435	thymidine kinase activity
RG60_RS10440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG60_RS10445	COG0745	RESPONSE REGULATOR receiver
RG60_RS10450	COG1752	Esterase of the alpha-beta hydrolase superfamily
RG60_RS10460	COG0788	formyltetrahydrofolate deformylase activity
RG60_RS10485	COG2181	nitrate reductase activity
RG60_RS10490	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG60_RS10495	COG1140	nitrate reductase beta subunit
RG60_RS10500	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG60_RS10505	COG2223	nitrite transmembrane transporter activity
RG60_RS10515	COG3850	Histidine kinase
RG60_RS10520	COG2197	response regulator
RG60_RS10525	COG4932	domain protein
RG60_RS10530	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RG60_RS10535	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RG60_RS10540	COG4572	Cation transport regulator
RG60_RS10545	COG0387	Pfam Sodium calcium exchanger
RG60_RS10580	COG2912	Transglutaminase-like superfamily
RG60_RS10585	COG3094	Invasion gene expression up-regulator, SirB
RG60_RS10590	COG2890	protein-(glutamine-N5) methyltransferase activity
RG60_RS10615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RG60_RS10620	COG0659	secondary active sulfate transmembrane transporter activity
RG60_RS10635	COG0012	GTP binding
RG60_RS10650	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS10655	COG3284	Transcriptional regulator
RG60_RS10660	COG2376	Dihydroxyacetone kinase
RG60_RS10665	COG1461	Dihydroxyacetone kinase
RG60_RS10670	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RG60_RS10670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS10670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG60_RS10695	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RG60_RS10710	COG1619	proteins homologs of microcin C7 resistance protein MccF
RG60_RS10725	COG2963	transposase activity
RG60_RS10730	COG2801	Transposase and inactivated derivatives
RG60_RS10735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG60_RS10745	COG2719	SpoVR family
RG60_RS10765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RG60_RS10770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RG60_RS10790	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG60_RS10820	COG2894	cell division
RG60_RS10880	COG2200	EAL domain
RG60_RS10905	COG2200	EAL domain
RG60_RS10910	COG0789	Transcriptional regulator
RG60_RS10915	COG5562	phage envelope protein
RG60_RS10930	COG0538	isocitrate dehydrogenase activity
RG60_RS10935	COG1187	pseudouridine synthase activity
RG60_RS10955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RG60_RS10965	COG2205	protein histidine kinase activity
RG60_RS10970	COG2850	peptidyl-arginine hydroxylation
RG60_RS10985	COG3842	ATPase activity
RG60_RS10995	COG1177	transmembrane transport
RG60_RS11000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG60_RS11010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG60_RS11015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RG60_RS11025	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG60_RS11030	COG1136	(ABC) transporter
RG60_RS11035	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG60_RS11040	COG4763	Acyl-transferase
RG60_RS11045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RG60_RS11050	COG1376	ErfK ybiS ycfS ynhG family protein
RG60_RS11050	COG1388	LysM domain
RG60_RS11060	COG1309	transcriptional regulator
RG60_RS11065	COG3134	Outer membrane lipoprotein
RG60_RS11075	COG1252	NADH dehydrogenase
RG60_RS11095	COG0510	thiamine kinase activity
RG60_RS11100	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
RG60_RS11105	COG5633	Lipoprotein
RG60_RS11110	COG0537	adenosine 5'-monophosphoramidase activity
RG60_RS11115	COG4773	Receptor
RG60_RS11120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS11120	COG1263	PTS System
RG60_RS11125	COG0084	hydrolase, TatD family'
RG60_RS11130	COG0470	DNA polymerase III
RG60_RS11140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RG60_RS11145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG60_RS11150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG60_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS11165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RG60_RS11185	COG1399	metal-binding, possibly nucleic acid-binding protein
RG60_RS11190	COG0424	maF-like protein
RG60_RS11195	COG0564	pseudouridine synthase activity
RG60_RS11205	COG1530	ribonuclease E activity
RG60_RS11210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG60_RS11215	COG1256	bacterial-type flagellum assembly
RG60_RS11220	COG1705	Flagellar rod assembly protein muramidase FlgJ
RG60_RS11220	COG3951	Flagellar rod assembly protein muramidase FlgJ
RG60_RS11235	COG4786	Flagellar basal body rod
RG60_RS11240	COG4787	bacterial-type flagellum-dependent cell motility
RG60_RS11245	COG1749	Flagellar hook protein flgE
RG60_RS11250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RG60_RS11255	COG1558	bacterial-type flagellum-dependent cell motility
RG60_RS11260	COG1815	bacterial-type flagellum-dependent cell motility
RG60_RS11265	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RG60_RS11270	COG2747	anti-sigma28 factor FlgM
RG60_RS11275	COG3418	PFAM FlgN family protein
RG60_RS11280	COG0728	peptidoglycan biosynthetic process
RG60_RS11285	COG0673	inositol 2-dehydrogenase activity
RG60_RS11295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG60_RS11305	COG2999	glutathione oxidoreductase activity
RG60_RS11345	COG3038	cytochrome b561
RG60_RS11350	COG2353	YceI-like domain
RG60_RS11360	COG1560	Kdo2-lipid A biosynthetic process
RG60_RS11380	COG5645	(Lipo)protein
RG60_RS11385	COG2943	transferase activity, transferring hexosyl groups
RG60_RS11400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG60_RS11405	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG60_RS11440	COG2197	response regulator
RG60_RS11455	COG1462	curli production assembly transport component CsgG
RG60_RS11465	COG3381	protein complex oligomerization
RG60_RS11505	COG2801	Transposase and inactivated derivatives
RG60_RS11510	COG3706	GGDEF domain
RG60_RS11515	COG0457	Tetratricopeptide repeat
RG60_RS11520	COG0726	polysaccharide deacetylase
RG60_RS11520	COG1649	PFAM Uncharacterised BCR, COG1649
RG60_RS11525	COG1215	transferase activity, transferring glycosyl groups
RG60_RS11530	COG3658	cytochrome
RG60_RS11535	COG1702	phosphate starvation-inducible protein PhoH
RG60_RS11550	COG2822	iron ion transport
RG60_RS11565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG60_RS11580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG60_RS11580	COG0506	proline dehydrogenase activity
RG60_RS11580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG60_RS11585	COG1309	transcriptional regulator
RG60_RS11620	COG2233	PERMEase
RG60_RS11625	COG3729	General stress protein
RG60_RS11635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG60_RS11685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG60_RS11725	COG0243	molybdopterin cofactor binding
RG60_RS11730	COG3005	denitrification pathway
RG60_RS11735	COG0745	RESPONSE REGULATOR receiver
RG60_RS11740	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS11750	COG0348	domain, Protein
RG60_RS11770	COG1278	Cold shock
RG60_RS11775	COG1278	Cold shock
RG60_RS11795	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG60_RS11805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG60_RS11810	COG0489	protein tyrosine kinase activity
RG60_RS11810	COG3206	protein involved in exopolysaccharide biosynthesis
RG60_RS11825	COG1294	oxidase, subunit
RG60_RS11830	COG1271	oxidase subunit
RG60_RS11835	COG1773	rubredoxin
RG60_RS11840	COG1999	signal sequence binding
RG60_RS11845	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG60_RS11850	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RG60_RS11855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG60_RS11860	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG60_RS11885	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG60_RS11970	COG4695	Portal protein
RG60_RS12045	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
RG60_RS12050	COG1403	HNH endonuclease
RG60_RS12125	COG1396	sequence-specific DNA binding
RG60_RS12170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG60_RS12185	COG0670	Belongs to the BI1 family
RG60_RS12190	COG2920	part of a sulfur-relay system
RG60_RS12195	COG1254	Belongs to the acylphosphatase family
RG60_RS12210	COG1832	CoA-binding protein
RG60_RS12230	COG0210	DNA helicase
RG60_RS12235	COG3304	Inner membrane component domain
RG60_RS12240	COG1289	transmembrane transporter activity
RG60_RS12245	COG3070	regulator of competence-specific genes
RG60_RS12260	COG2885	chlorophyll binding
RG60_RS12260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG60_RS12270	COG1067	ATP-dependent peptidase activity
RG60_RS12280	COG3130	regulation of translation
RG60_RS12285	COG3009	Protein conserved in bacteria
RG60_RS12290	COG3008	intermembrane lipid transfer
RG60_RS12290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG60_RS12295	COG2995	paraquat-inducible protein a
RG60_RS12300	COG0488	(ABC) transporter
RG60_RS12310	COG3217	Mosc domain protein beta barrel domain protein
RG60_RS12310	COG0633	Ferredoxin
RG60_RS12325	COG3121	Chaperone
RG60_RS12330	COG3539	Fimbrial protein
RG60_RS12335	COG3539	Fimbrial protein
RG60_RS12340	COG3539	Fimbrial protein
RG60_RS12345	COG3188	usher protein
RG60_RS12350	COG3121	Chaperone
RG60_RS12355	COG3539	Fimbrial protein
RG60_RS12365	COG0431	NADPH-dependent FMN reductase
RG60_RS12370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RG60_RS12380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG60_RS12395	COG0308	aminopeptidase N
RG60_RS12420	COG1448	Aminotransferase
RG60_RS12425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RG60_RS12430	COG3108	Peptidase M15
RG60_RS12440	COG2989	Protein conserved in bacteria
RG60_RS12450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RG60_RS12460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RG60_RS12465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG60_RS12470	COG3173	Aminoglycoside phosphotransferase
RG60_RS12485	COG3214	Protein conserved in bacteria
RG60_RS12495	COG1132	(ABC) transporter
RG60_RS12500	COG0658	competence protein
RG60_RS12500	COG2333	competence protein COMEC
RG60_RS12510	COG0539	negative regulation of cytoplasmic translation
RG60_RS12520	COG0501	Belongs to the peptidase M48B family
RG60_RS12535	COG2323	membrane
RG60_RS12540	COG1944	ATP diphosphatase activity
RG60_RS12545	COG2116	formate transmembrane transporter activity
RG60_RS12550	COG1882	Formate acetyltransferase
RG60_RS12555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG60_RS12560	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG60_RS12565	COG0583	DNA-binding transcription factor activity
RG60_RS12570	COG0531	amino acid
RG60_RS12580	COG1335	isochorismatase
RG60_RS12585	COG3302	dmso reductase anchor subunit
RG60_RS12590	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS12595	COG0243	molybdopterin cofactor binding
RG60_RS12605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RG60_RS12620	COG1522	sequence-specific DNA binding
RG60_RS12630	COG0492	ferredoxin-NADP+ reductase activity
RG60_RS12635	COG4988	ABC transporter
RG60_RS12640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RG60_RS12670	COG0542	response to heat
RG60_RS12680	COG1278	Cold shock
RG60_RS12685	COG1136	(ABC) transporter
RG60_RS12685	COG0577	efflux transmembrane transporter activity
RG60_RS12690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS12695	COG2990	Protein conserved in bacteria
RG60_RS12700	COG3593	DNA synthesis involved in DNA repair
RG60_RS12720	COG2431	L-lysine efflux transmembrane transporter activity
RG60_RS12730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG60_RS12735	COG0028	Belongs to the TPP enzyme family
RG60_RS12740	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RG60_RS12745	COG0702	epimerase
RG60_RS12750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG60_RS12755	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG60_RS12770	COG1126	abc transporter atp-binding protein
RG60_RS12775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS12780	COG4215	(ABC) transporter
RG60_RS12785	COG4160	amino acid transport
RG60_RS12790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS12810	COG1177	transmembrane transport
RG60_RS12815	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG60_RS12820	COG3842	ATPase activity
RG60_RS12825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG60_RS12845	COG0778	Nitroreductase
RG60_RS12855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG60_RS12870	COG3226	Transcriptional regulator
RG60_RS12875	COG0738	Major facilitator superfamily
RG60_RS12880	COG0561	phosphatase activity
RG60_RS12890	COG2814	Major facilitator Superfamily
RG60_RS12895	COG0671	phosphoesterase, PA-phosphatase related
RG60_RS12900	COG1349	DNA-binding transcription factor activity
RG60_RS12905	COG1686	Belongs to the peptidase S11 family
RG60_RS12910	COG0625	glutathione transferase activity
RG60_RS12915	COG2133	pyrroloquinoline quinone binding
RG60_RS12930	COG2199	diguanylate cyclase activity
RG60_RS12935	COG2200	EAL domain
RG60_RS12960	COG1446	asparaginase
RG60_RS12965	COG0303	'Molybdopterin
RG60_RS12970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG60_RS12975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG60_RS12980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG60_RS12985	COG1882	Formate acetyltransferase
RG60_RS12990	COG0561	phosphatase activity
RG60_RS13000	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS13005	COG0488	(ABC) transporter
RG60_RS13010	COG1376	ErfK ybiS ycfS ynhG family protein
RG60_RS13015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG60_RS13020	COG1321	iron dependent repressor
RG60_RS13030	COG2194	sulfuric ester hydrolase activity
RG60_RS13035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG60_RS13065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS13070	COG0765	amino acid transport
RG60_RS13075	COG1126	abc transporter atp-binding protein
RG60_RS13085	COG0668	transmembrane transport
RG60_RS13100	COG4774	siderophore transport
RG60_RS13110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG60_RS13120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG60_RS13125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG60_RS13130	COG1199	ATP-dependent helicase activity
RG60_RS13140	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RG60_RS13145	COG0513	Belongs to the DEAD box helicase family
RG60_RS13150	COG1309	transcriptional regulator
RG60_RS13160	COG1131	(ABC) transporter
RG60_RS13165	COG0842	Transport permease protein
RG60_RS13170	COG0842	Transport permease protein
RG60_RS13180	COG3568	Endonuclease Exonuclease Phosphatase
RG60_RS13185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG60_RS13190	COG0392	lysyltransferase activity
RG60_RS13195	COG0670	Belongs to the BI1 family
RG60_RS13200	COG0670	Belongs to the BI1 family
RG60_RS13205	COG0314	molybdopterin synthase activity
RG60_RS13210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RG60_RS13220	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG60_RS13230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RG60_RS13240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG60_RS13245	COG2226	methyltransferase
RG60_RS13260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RG60_RS13265	COG1881	PFAM PEBP family protein
RG60_RS13275	COG4677	pectinesterase activity
RG60_RS13280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG60_RS13285	COG0471	metal ion transport
RG60_RS13290	COG2828	Protein conserved in bacteria
RG60_RS13295	COG0583	DNA-binding transcription factor activity
RG60_RS13305	COG0561	phosphatase activity
RG60_RS13315	COG4149	molybdate abc transporter
RG60_RS13320	COG0725	ABC transporter, periplasmic molybdate-binding protein
RG60_RS13335	COG2005	Transcriptional regulator
RG60_RS13335	COG3585	molybdate ion transport
RG60_RS13340	COG1119	ATPase activity
RG60_RS13345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RG60_RS13350	COG1085	galactose-1-phosphate uridylyltransferase
RG60_RS13360	COG2017	converts alpha-aldose to the beta-anomer
RG60_RS13370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG60_RS13385	COG1230	cation diffusion facilitator family transporter
RG60_RS13390	COG3201	nicotinamide mononucleotide transporter
RG60_RS13440	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RG60_RS13445	COG2885	chlorophyll binding
RG60_RS13455	COG3064	Membrane
RG60_RS13460	COG0848	biopolymer transport protein
RG60_RS13465	COG0811	peptide transport
RG60_RS13470	COG0824	Thioesterase
RG60_RS13475	COG3790	cyd operon protein YbgE
RG60_RS13480	COG4890	Cyd operon protein YbgT
RG60_RS13485	COG1294	oxidase, subunit
RG60_RS13490	COG1271	oxidase subunit
RG60_RS13500	COG0383	alpha-mannosidase activity
RG60_RS13505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS13505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS13505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS13510	COG2188	Transcriptional regulator
RG60_RS13515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG60_RS13525	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG60_RS13530	COG0567	Dehydrogenase, E1 component
RG60_RS13540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG60_RS13545	COG1053	succinate dehydrogenase
RG60_RS13550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RG60_RS13555	COG2009	succinate dehydrogenase
RG60_RS13575	COG0372	Belongs to the citrate synthase family
RG60_RS13580	COG3539	Fimbrial protein
RG60_RS13585	COG3188	usher protein
RG60_RS13590	COG3121	Chaperone
RG60_RS13595	COG3539	Fimbrial protein
RG60_RS13600	COG3180	Ammonia monooxygenase
RG60_RS13615	COG1984	allophanate hydrolase subunit 2
RG60_RS13620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RG60_RS13625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RG60_RS13635	COG0415	Belongs to the DNA photolyase family
RG60_RS13640	COG3272	Protein of unknown function (DUF1722)
RG60_RS13650	COG5433	transposase activity
RG60_RS13660	COG3209	COG3209 Rhs family protein
RG60_RS13670	COG3209	COG3209 Rhs family protein
RG60_RS13700	COG2205	protein histidine kinase activity
RG60_RS13705	COG0745	RESPONSE REGULATOR receiver
RG60_RS13720	COG1982	Orn Lys Arg decarboxylase major
RG60_RS13725	COG0531	amino acid
RG60_RS13730	COG0033	Phosphoglucomutase
RG60_RS13735	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RG60_RS13740	COG0596	Alpha beta hydrolase
RG60_RS13750	COG0716	FMN binding
RG60_RS13765	COG0735	belongs to the Fur family
RG60_RS13790	COG2190	(PTS) system
RG60_RS13790	COG1263	PTS System
RG60_RS13790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS13800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG60_RS13805	COG1940	carbohydrate kinase activity
RG60_RS13805	COG1846	Transcriptional regulator
RG60_RS13810	COG0647	UMP catabolic process
RG60_RS13820	COG0367	asparagine synthase
RG60_RS13865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG60_RS13875	COG1702	phosphate starvation-inducible protein PhoH
RG60_RS13885	COG4535	Mg2 and Co2 transporter CorC
RG60_RS13890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RG60_RS13905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS13910	COG0765	amino acid transport
RG60_RS13915	COG0765	amino acid transport
RG60_RS13920	COG1126	abc transporter atp-binding protein
RG60_RS13940	COG2214	Heat shock protein DnaJ domain protein
RG60_RS13950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG60_RS13955	COG2214	Heat shock protein DnaJ domain protein
RG60_RS13965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG60_RS13970	COG2888	peptidyl-tyrosine sulfation
RG60_RS13985	COG1466	dna polymerase III delta subunit
RG60_RS13995	COG0406	alpha-ribazole phosphatase activity
RG60_RS14000	COG0799	negative regulation of ribosome biogenesis
RG60_RS14010	COG0768	penicillin binding
RG60_RS14015	COG0772	Belongs to the SEDS family
RG60_RS14020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG60_RS14025	COG1686	Belongs to the peptidase S11 family
RG60_RS14045	COG0583	DNA-binding transcription factor activity
RG60_RS14060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG60_RS14065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG60_RS14090	COG3069	C4-dicarboxylate transmembrane transporter activity
RG60_RS14095	COG4565	transcriptional regulatory protein
RG60_RS14100	COG3290	protein histidine kinase activity
RG60_RS14105	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RG60_RS14115	COG2301	Belongs to the HpcH HpaI aldolase family
RG60_RS14120	COG3051	citrate lyase alpha subunit
RG60_RS14135	COG0471	metal ion transport
RG60_RS14140	COG3719	Belongs to the RNase T2 family
RG60_RS14150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG60_RS14160	COG1063	alcohol dehydrogenase
RG60_RS14165	COG0589	response to stress
RG60_RS14170	COG3634	alkyl hydroperoxide reductase activity
RG60_RS14175	COG0450	alkyl hydroperoxide reductase
RG60_RS14180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG60_RS14185	COG0583	DNA-binding transcription factor activity
RG60_RS14190	COG3969	phosphoadenosine phosphosulfate
RG60_RS14195	COG1475	DNA binding
RG60_RS14200	COG0436	Aminotransferase
RG60_RS14205	COG0371	Dehydrogenase
RG60_RS14210	COG2879	small protein
RG60_RS14215	COG1966	Carbon starvation protein
RG60_RS14220	COG2050	protein possibly involved in aromatic compounds catabolism
RG60_RS14225	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS14230	COG1535	isochorismatase
RG60_RS14230	COG3433	isochorismatase activity
RG60_RS14235	COG1021	2,3-dihydroxybenzoate-AMP ligase
RG60_RS14240	COG1169	isochorismate synthase
RG60_RS14250	COG4592	Periplasmic binding protein
RG60_RS14260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG60_RS14265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG60_RS14270	COG1120	ATPase activity
RG60_RS14275	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG60_RS14280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG60_RS14280	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RG60_RS14285	COG3251	PFAM MbtH domain protein
RG60_RS14290	COG2382	esterase
RG60_RS14300	COG4771	TonB-dependent receptor
RG60_RS14305	COG2977	Belongs to the P-Pant transferase superfamily
RG60_RS14345	COG2315	Protein conserved in bacteria
RG60_RS14350	COG0778	Nitroreductase
RG60_RS14355	COG0668	transmembrane transport
RG60_RS14360	COG1113	amino acid transport
RG60_RS14365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG60_RS14370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS14375	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS14380	COG1538	Outer membrane efflux protein
RG60_RS14390	COG0745	RESPONSE REGULATOR receiver
RG60_RS14395	COG5002	protein histidine kinase activity
RG60_RS14405	COG3501	Rhs element vgr protein
RG60_RS14415	COG4104	PAAR repeat-containing protein
RG60_RS14415	COG3209	COG3209 Rhs family protein
RG60_RS14430	COG5433	transposase activity
RG60_RS14435	COG1215	transferase activity, transferring glycosyl groups
RG60_RS14440	COG4783	chaperone-mediated protein folding
RG60_RS14455	COG2207	Transcriptional regulator
RG60_RS14465	COG2197	response regulator
RG60_RS14470	COG3539	Fimbrial protein
RG60_RS14475	COG3539	Fimbrial protein
RG60_RS14485	COG3121	Chaperone
RG60_RS14490	COG3539	Fimbrial protein
RG60_RS14500	COG2501	S4 domain
RG60_RS14505	COG1988	membrane-bound metal-dependent
RG60_RS14515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG60_RS14530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RG60_RS14535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RG60_RS14540	COG0549	Belongs to the carbamate kinase family
RG60_RS14555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG60_RS14560	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG60_RS14565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG60_RS14570	COG3257	ureidoglycine aminohydrolase activity
RG60_RS14575	COG1929	Belongs to the glycerate kinase type-1 family
RG60_RS14580	COG2233	PERMEase
RG60_RS14600	COG2084	Dehydrogenase
RG60_RS14605	COG3622	Belongs to the hyi family
RG60_RS14610	COG3960	tartronate-semialdehyde synthase activity
RG60_RS14615	COG1414	Transcriptional regulator
RG60_RS14625	COG0583	DNA-binding transcription factor activity
RG60_RS14635	COG2801	Transposase and inactivated derivatives
RG60_RS14645	COG3209	COG3209 Rhs family protein
RG60_RS14650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RG60_RS14655	COG4181	ATPase activity
RG60_RS14660	COG2755	lipolytic protein G-D-S-L family
RG60_RS14665	COG0300	oxidoreductase activity
RG60_RS14670	COG3118	belongs to the thioredoxin family
RG60_RS14675	COG0390	transport system, permease component
RG60_RS14680	COG4619	ABC transporter
RG60_RS14685	COG0330	HflC and HflK could
RG60_RS14690	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG60_RS14695	COG0789	Transcriptional regulator
RG60_RS14705	COG0531	amino acid
RG60_RS14710	COG2066	Belongs to the glutaminase family
RG60_RS14715	COG2217	Heavy metal translocating P-type atpase
RG60_RS14730	COG3093	addiction module antidote protein HigA
RG60_RS14735	COG3735	TraB family
RG60_RS14740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG60_RS14745	COG0737	Belongs to the 5'-nucleotidase family
RG60_RS14755	COG2223	nitrite transmembrane transporter activity
RG60_RS14760	COG4651	solute:proton antiporter activity
RG60_RS14760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG60_RS14765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG60_RS14800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RG60_RS14815	COG2832	Protein of unknown function (DUF454)
RG60_RS14820	COG3923	Primosomal replication protein n
RG60_RS14835	COG1196	nuclear chromosome segregation
RG60_RS14835	COG3264	Mechanosensitive ion channel
RG60_RS14845	COG1309	transcriptional regulator
RG60_RS14850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS14855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG60_RS14870	COG0110	maltose O-acetyltransferase activity
RG60_RS14880	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG60_RS14885	COG5507	3-demethylubiquinone-9 3-methyltransferase
RG60_RS14895	COG3695	enzyme binding
RG60_RS14900	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RG60_RS14905	COG1946	Acyl-CoA thioesterase
RG60_RS14910	COG0004	ammonium transporteR
RG60_RS14915	COG0347	Belongs to the P(II) protein family
RG60_RS14920	COG1132	(ABC) transporter
RG60_RS14925	COG1132	(ABC) transporter
RG60_RS14930	COG1522	sequence-specific DNA binding
RG60_RS14940	COG4533	DNA binding
RG60_RS14950	COG0824	Thioesterase
RG60_RS14955	COG1555	photosystem II stabilization
RG60_RS14960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG60_RS14965	COG0776	regulation of translation
RG60_RS14970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RG60_RS14995	COG0271	Belongs to the BolA IbaG family
RG60_RS15000	COG3056	Lipoprotein
RG60_RS15005	COG2223	nitrite transmembrane transporter activity
RG60_RS15010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RG60_RS15015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RG60_RS15020	COG1845	cytochrome c oxidase, subunit III
RG60_RS15025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RG60_RS15050	COG2814	Major facilitator Superfamily
RG60_RS15060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RG60_RS15065	COG0693	protein deglycase activity
RG60_RS15080	COG0142	geranyltranstransferase activity
RG60_RS15090	COG0667	Aldo Keto reductase
RG60_RS15095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RG60_RS15100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RG60_RS15115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG60_RS15115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG60_RS15125	COG4238	major outer membrane lipoprotein
RG60_RS15130	COG3248	Nucleoside-binding outer membrane protein
RG60_RS15135	COG1403	HNH endonuclease
RG60_RS15140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG60_RS15145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG60_RS15150	COG1862	Preprotein translocase
RG60_RS15170	COG0366	Alpha amylase catalytic
RG60_RS15175	COG1113	amino acid transport
RG60_RS15180	COG1114	Component of the transport system for branched-chain amino acids
RG60_RS15185	COG5002	protein histidine kinase activity
RG60_RS15190	COG0745	RESPONSE REGULATOR receiver
RG60_RS15195	COG0420	3'-5' exonuclease activity
RG60_RS15200	COG0419	ATPase involved in DNA repair
RG60_RS15205	COG2814	Major facilitator Superfamily
RG60_RS15210	COG1940	carbohydrate kinase activity
RG60_RS15235	COG4126	flavin adenine dinucleotide binding
RG60_RS15260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RG60_RS15265	COG3706	GGDEF domain
RG60_RS15275	COG1785	Belongs to the alkaline phosphatase family
RG60_RS15290	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG60_RS15310	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RG60_RS15320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG60_RS15325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG60_RS15330	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS15340	COG0113	porphobilinogen synthase activity
RG60_RS15345	COG2175	clavaminate synthase activity
RG60_RS15350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG60_RS15360	COG4521	taurine ABC transporter
RG60_RS15370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RG60_RS15375	COG1215	transferase activity, transferring glycosyl groups
RG60_RS15405	COG3122	Protein conserved in bacteria
RG60_RS15410	COG2814	Major facilitator Superfamily
RG60_RS15450	COG1414	Transcriptional regulator
RG60_RS15455	COG1609	Transcriptional regulator
RG60_RS15465	COG3250	beta-galactosidase activity
RG60_RS15470	COG2223	nitrite transmembrane transporter activity
RG60_RS15475	COG0110	maltose O-acetyltransferase activity
RG60_RS15480	COG2807	transmembrane transport
RG60_RS15490	COG0288	reversible hydration of carbon dioxide
RG60_RS15495	COG0583	DNA-binding transcription factor activity
RG60_RS15500	COG0402	S-adenosylhomocysteine deaminase activity
RG60_RS15505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RG60_RS15510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG60_RS15515	COG2079	MmgE PrpD family protein
RG60_RS15520	COG0372	Belongs to the citrate synthase family
RG60_RS15525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RG60_RS15530	COG3829	transcription factor binding
RG60_RS15540	COG1280	lysine exporter protein (LysE YggA)
RG60_RS15555	COG1064	alcohol dehydrogenase
RG60_RS15565	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG60_RS15570	COG1129	ABC transporter
RG60_RS15575	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS15585	COG0402	S-adenosylhomocysteine deaminase activity
RG60_RS15590	COG0549	Belongs to the carbamate kinase family
RG60_RS15595	COG1304	FMN binding
RG60_RS15600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG60_RS15610	COG0666	response to abiotic stimulus
RG60_RS15625	COG0583	DNA-binding transcription factor activity
RG60_RS15630	COG2200	EAL domain
RG60_RS15630	COG2771	luxR family
RG60_RS15640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG60_RS15695	COG1556	Lactate utilization protein
RG60_RS15700	COG1139	Iron-sulfur cluster binding protein
RG60_RS15705	COG0247	lactate metabolic process
RG60_RS15710	COG2207	Transcriptional regulator
RG60_RS15715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG60_RS15725	COG3059	membrane
RG60_RS15730	COG0656	L-ascorbic acid biosynthetic process
RG60_RS15735	COG2207	Transcriptional regulator
RG60_RS15735	COG3708	Transcriptional regulator
RG60_RS15740	COG1388	LysM domain
RG60_RS15800	COG3121	Chaperone
RG60_RS15805	COG0727	PFAM Uncharacterised protein family (UPF0153)
RG60_RS15815	COG3477	response to acidic pH
RG60_RS15825	COG2080	2 iron, 2 sulfur cluster binding
RG60_RS15830	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG60_RS15835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG60_RS15840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG60_RS15845	COG0583	DNA-binding transcription factor activity
RG60_RS15890	COG2003	Belongs to the UPF0758 family
RG60_RS15925	COG2020	methyltransferase activity
RG60_RS15930	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS16015	COG1358	cellular component organization or biogenesis
RG60_RS16050	COG4245	von Willebrand factor, type A
RG60_RS16055	COG4245	von Willebrand factor, type A
RG60_RS16070	COG4372	Transposase
RG60_RS16075	COG3436	PFAM IS66 Orf2 family protein
RG60_RS16085	COG2963	transposase activity
RG60_RS16090	COG2801	Transposase and inactivated derivatives
RG60_RS16120	COG2433	Pfam Transposase IS66
RG60_RS16130	COG2814	Major facilitator Superfamily
RG60_RS16135	COG0673	inositol 2-dehydrogenase activity
RG60_RS16245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS16255	COG3037	sugar-specific permease SgaT UlaA
RG60_RS16275	COG0738	Major facilitator superfamily
RG60_RS16285	COG1349	DNA-binding transcription factor activity
RG60_RS16290	COG0440	acetolactate synthase activity
RG60_RS16295	COG0440	acetolactate synthase activity
RG60_RS16335	COG2211	Major facilitator Superfamily
RG60_RS16340	COG1917	Cupin 2, conserved barrel domain protein
RG60_RS16345	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS16350	COG0823	Involved in the tonB-independent uptake of proteins
RG60_RS16460	COG1120	ATPase activity
RG60_RS16465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG60_RS16480	COG0456	acetyltransferase
RG60_RS16485	COG1396	sequence-specific DNA binding
RG60_RS16555	COG2003	Belongs to the UPF0758 family
RG60_RS16605	COG3436	PFAM IS66 Orf2 family protein
RG60_RS16640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG60_RS16650	COG2226	methyltransferase
RG60_RS16660	COG1388	LysM domain
RG60_RS16660	COG0741	lytic transglycosylase activity
RG60_RS16665	COG2226	methyltransferase
RG60_RS16675	COG0583	DNA-binding transcription factor activity
RG60_RS16680	COG0656	L-ascorbic acid biosynthetic process
RG60_RS16715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG60_RS16720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RG60_RS16725	COG2011	ABC-type metal ion transport system permease component
RG60_RS16730	COG1464	Belongs to the NlpA lipoprotein family
RG60_RS16740	COG1720	tRNA m6t6A37 methyltransferase activity
RG60_RS16750	COG0791	NLP P60 protein
RG60_RS16760	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS16765	COG3015	lipoprotein NlpE involved in copper resistance
RG60_RS16770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG60_RS16775	COG4681	YaeQ
RG60_RS16785	COG4568	rho-dependent transcription termination
RG60_RS16795	COG0346	lactoylglutathione lyase activity
RG60_RS16800	COG1982	Orn Lys Arg decarboxylase major
RG60_RS16810	COG0587	DNA-directed DNA polymerase activity
RG60_RS16835	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RG60_RS16840	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RG60_RS16850	COG0750	zinc metalloprotease
RG60_RS16855	COG0575	Belongs to the CDS family
RG60_RS16860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RG60_RS16865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RG60_RS16900	COG0024	Methionine aminopeptidase
RG60_RS16920	COG3835	regulator
RG60_RS16925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG60_RS16945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG60_RS16950	COG2860	membrane
RG60_RS16970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG60_RS16975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG60_RS16980	COG1120	ATPase activity
RG60_RS16985	COG4774	siderophore transport
RG60_RS16990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RG60_RS17000	COG1643	Atp-dependent helicase
RG60_RS17005	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RG60_RS17015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG60_RS17025	COG0617	tRNA 3'-terminal CCA addition
RG60_RS17030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RG60_RS17035	COG3539	Fimbrial protein
RG60_RS17040	COG3121	Chaperone
RG60_RS17045	COG3188	usher protein
RG60_RS17050	COG3539	Fimbrial protein
RG60_RS17055	COG3539	Fimbrial protein
RG60_RS17060	COG3539	Fimbrial protein
RG60_RS17065	COG3539	Fimbrial protein
RG60_RS17080	COG5464	transposase or invertase
RG60_RS17100	COG0726	polysaccharide deacetylase
RG60_RS17105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS17110	COG0842	Transport permease protein
RG60_RS17115	COG1131	(ABC) transporter
RG60_RS17120	COG0288	reversible hydration of carbon dioxide
RG60_RS17125	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RG60_RS17130	COG4993	Dehydrogenase
RG60_RS17135	COG2132	Multicopper oxidase
RG60_RS17160	COG1049	propionate catabolic process, 2-methylcitrate cycle
RG60_RS17170	COG3064	Membrane
RG60_RS17175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG60_RS17180	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG60_RS17185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RG60_RS17195	COG2186	Transcriptional regulator
RG60_RS17200	COG1113	amino acid transport
RG60_RS17205	COG3725	Membrane protein required for beta-lactamase induction
RG60_RS17210	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG60_RS17215	COG0157	Belongs to the NadC ModD family
RG60_RS17225	COG4969	Belongs to the N-Me-Phe pilin family
RG60_RS17230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG60_RS17235	COG1459	type II secretion system
RG60_RS17260	COG0494	nUDIX hydrolase
RG60_RS17280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RG60_RS17285	COG0849	cell division
RG60_RS17290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RG60_RS17295	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG60_RS17310	COG0772	Belongs to the SEDS family
RG60_RS17325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RG60_RS17330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG60_RS17335	COG0768	penicillin binding
RG60_RS17340	COG3116	cell division
RG60_RS17360	COG1609	Transcriptional regulator
RG60_RS17370	COG0440	acetolactate synthase activity
RG60_RS17375	COG0028	Belongs to the TPP enzyme family
RG60_RS17380	COG0583	DNA-binding transcription factor activity
RG60_RS17395	COG0473	3-isopropylmalate dehydrogenase activity
RG60_RS17410	COG2814	Major facilitator Superfamily
RG60_RS17425	COG4143	(ABC) transporter
RG60_RS17430	COG1178	ABC-type Fe3 transport system permease component
RG60_RS17440	COG0586	Pfam SNARE associated Golgi protein
RG60_RS17445	COG4977	sequence-specific DNA binding
RG60_RS17465	COG0235	Class ii aldolase
RG60_RS17470	COG0417	DNA replication proofreading
RG60_RS17480	COG0564	pseudouridine synthase activity
RG60_RS17485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RG60_RS17490	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG60_RS17495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG60_RS17535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RG60_RS17550	COG2271	Major facilitator Superfamily
RG60_RS17555	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG60_RS17560	COG0644	oxidoreductase
RG60_RS17615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RG60_RS17620	COG0505	Belongs to the CarA family
RG60_RS17640	COG1047	Peptidyl-prolyl cis-trans
RG60_RS17655	COG0196	riboflavin kinase activity
RG60_RS17675	COG3188	usher protein
RG60_RS17685	COG0583	DNA-binding transcription factor activity
RG60_RS17715	COG4735	regulation of single-species biofilm formation
RG60_RS17720	COG1584	GPR1 FUN34 yaaH family protein
RG60_RS17725	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG60_RS17745	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS17760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RG60_RS17770	COG0460	homoserine dehydrogenase
RG60_RS17770	COG0527	aspartate kinase activity
RG60_RS17780	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RG60_RS17795	COG0745	RESPONSE REGULATOR receiver
RG60_RS17800	COG4452	Inner membrane protein CreD
RG60_RS17805	COG2205	protein histidine kinase activity
RG60_RS17810	COG0745	RESPONSE REGULATOR receiver
RG60_RS17815	COG3045	CreA protein
RG60_RS17820	COG3708	Transcriptional regulator
RG60_RS17820	COG2207	Transcriptional regulator
RG60_RS17840	COG0741	lytic transglycosylase activity
RG60_RS17850	COG0488	(ABC) transporter
RG60_RS17860	COG1056	cytidyltransferase-related domain
RG60_RS17860	COG3172	ATPase kinase involved in NAD metabolism
RG60_RS17865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RG60_RS17870	COG0560	Phosphoserine phosphatase
RG60_RS17875	COG3726	membrane protein affecting hemolysin expression
RG60_RS17915	COG1328	CTP reductase activity
RG60_RS17920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG60_RS17925	COG0084	hydrolase, TatD family'
RG60_RS17930	COG4667	esterase of the alpha-beta hydrolase superfamily
RG60_RS17940	COG2823	Periplasmic or secreted lipoprotein
RG60_RS17950	COG1011	Hydrolase
RG60_RS17955	COG0456	acetyltransferase
RG60_RS17960	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
RG60_RS17995	COG4114	ferric iron reductase
RG60_RS18000	COG2197	response regulator
RG60_RS18005	COG2197	response regulator
RG60_RS18010	COG2966	Psort location CytoplasmicMembrane, score
RG60_RS18025	COG1484	DNA-dependent DNA replication
RG60_RS18040	COG1063	alcohol dehydrogenase
RG60_RS18045	COG1802	Transcriptional regulator
RG60_RS18050	COG1802	Transcriptional regulator
RG60_RS18055	COG2271	Major facilitator Superfamily
RG60_RS18060	COG0840	transmembrane signaling receptor activity
RG60_RS18065	COG1846	Transcriptional regulator
RG60_RS18070	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG60_RS18075	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS18080	COG3384	dioxygenase
RG60_RS18090	COG3971	2-oxopent-4-enoate hydratase activity
RG60_RS18110	COG2368	4-hydroxyphenylacetate
RG60_RS18115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG60_RS18120	COG1966	Carbon starvation protein
RG60_RS18125	COG2879	small protein
RG60_RS18130	COG0523	cobalamin synthesis protein
RG60_RS18140	COG5457	Domain of unknown function (DUF1127)
RG60_RS18145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG60_RS18155	COG2814	Major facilitator Superfamily
RG60_RS18160	COG2733	membrane
RG60_RS18165	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RG60_RS18170	COG1924	4 iron, 4 sulfur cluster binding
RG60_RS18185	COG0477	Major facilitator Superfamily
RG60_RS18200	COG3366	ferrous iron transmembrane transporter activity
RG60_RS18205	COG0700	Nucleoside recognition
RG60_RS18210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG60_RS18215	COG0583	DNA-binding transcription factor activity
RG60_RS18235	COG2186	Transcriptional regulator
RG60_RS18245	COG0246	Mannitol dehydrogenase
RG60_RS18260	COG2610	gluconate transmembrane transporter activity
RG60_RS18265	COG3539	Fimbrial protein
RG60_RS18270	COG3539	Fimbrial protein
RG60_RS18275	COG3539	Fimbrial protein
RG60_RS18280	COG3188	usher protein
RG60_RS18285	COG3121	Chaperone
RG60_RS18290	COG3539	Fimbrial protein
RG60_RS18310	COG4974	Belongs to the 'phage' integrase family
RG60_RS18315	COG0582	viral genome integration into host DNA
RG60_RS18330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG60_RS18335	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
RG60_RS18350	COG1401	restriction endodeoxyribonuclease activity
RG60_RS18380	COG2801	Transposase and inactivated derivatives
RG60_RS18420	COG0515	serine threonine protein kinase
RG60_RS18420	COG2815	serine threonine protein kinase
RG60_RS18425	COG0582	viral genome integration into host DNA
RG60_RS18495	COG0582	viral genome integration into host DNA
RG60_RS18505	COG1064	alcohol dehydrogenase
RG60_RS18510	COG3265	gluconokinase activity
RG60_RS18520	COG1063	alcohol dehydrogenase
RG60_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS18530	COG2610	gluconate transmembrane transporter activity
RG60_RS18535	COG1609	Transcriptional regulator
RG60_RS18540	COG0433	COG0433 Predicted ATPase
RG60_RS18545	COG0795	lipopolysaccharide-transporting ATPase activity
RG60_RS18550	COG0795	lipopolysaccharide-transporting ATPase activity
RG60_RS18560	COG2927	DNA polymerase III (CHI subunit)
RG60_RS18565	COG0525	valine-tRNA ligase activity
RG60_RS18570	COG4269	membrane
RG60_RS18575	COG0456	acetyltransferase
RG60_RS18580	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
RG60_RS18595	COG2731	YhcH YjgK YiaL family protein
RG60_RS18600	COG1309	transcriptional regulator
RG60_RS18605	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS18610	COG0251	oxidation-reduction process
RG60_RS18635	COG0251	oxidation-reduction process
RG60_RS18640	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS18645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RG60_RS18650	COG1609	Transcriptional regulator
RG60_RS18655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS18655	COG1263	PTS System
RG60_RS18660	COG0366	Alpha amylase catalytic
RG60_RS18665	COG1328	CTP reductase activity
RG60_RS18670	COG0602	queuosine metabolic process
RG60_RS18675	COG3783	Cytochrome b(562)
RG60_RS18680	COG0312	modulator of DNA gyrase
RG60_RS18690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RG60_RS18700	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG60_RS18705	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG60_RS18710	COG1129	ABC transporter
RG60_RS18715	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS18720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RG60_RS18725	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG60_RS18730	COG2336	PFAM SpoVT AbrB
RG60_RS18735	COG2105	PFAM AIG2 family protein
RG60_RS18740	COG2911	Protein conserved in bacteria
RG60_RS18745	COG0729	surface antigen
RG60_RS18760	COG1253	flavin adenine dinucleotide binding
RG60_RS18770	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG60_RS18775	COG1218	3'(2'),5'-bisphosphate nucleotidase
RG60_RS18785	COG1733	regulation of RNA biosynthetic process
RG60_RS18790	COG0702	epimerase
RG60_RS18795	COG0697	spore germination
RG60_RS18805	COG1113	amino acid transport
RG60_RS18810	COG0545	Peptidyl-prolyl cis-trans isomerase
RG60_RS18820	COG3061	Opacity-associated protein A
RG60_RS18825	COG1309	transcriptional regulator
RG60_RS18830	COG0675	Transposase, IS605 OrfB family
RG60_RS18840	COG1309	transcriptional regulator
RG60_RS18855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RG60_RS18880	COG3477	response to acidic pH
RG60_RS18910	COG3037	sugar-specific permease SgaT UlaA
RG60_RS18925	COG1073	alpha beta
RG60_RS18930	COG3650	response to hydrogen peroxide
RG60_RS18945	COG1960	acyl-CoA dehydrogenase activity
RG60_RS18950	COG0754	glutathionylspermidine amidase activity
RG60_RS18955	COG5463	Belongs to the UPF0441 family
RG60_RS18960	COG3766	membrane
RG60_RS18970	COG1842	Phage shock protein A
RG60_RS18975	COG3789	protein conserved in bacteria
RG60_RS18980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG60_RS18985	COG0557	exoribonuclease II activity
RG60_RS19000	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RG60_RS19005	COG0330	HflC and HflK could
RG60_RS19010	COG0330	HflC and HflK could
RG60_RS19015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RG60_RS19035	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG60_RS19040	COG0802	atpase or kinase
RG60_RS19045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RG60_RS19045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RG60_RS19085	COG3264	Mechanosensitive ion channel
RG60_RS19085	COG1511	domain protein
RG60_RS19090	COG0531	amino acid
RG60_RS19100	COG1053	succinate dehydrogenase
RG60_RS19105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG60_RS19120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG60_RS19125	COG3040	lipid binding
RG60_RS19130	COG2076	Multidrug Resistance protein
RG60_RS19135	COG5510	response to toxic substance
RG60_RS19140	COG5510	response to toxic substance
RG60_RS19150	COG1509	lysine 2,3-aminomutase activity
RG60_RS19160	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS19180	COG0531	amino acid
RG60_RS19185	COG3030	protein affecting phage T7 exclusion by the F plasmid
RG60_RS19195	COG1027	Aspartate ammonia-lyase
RG60_RS19200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG60_RS19215	COG1309	transcriptional regulator
RG60_RS19230	COG3710	Transcriptional regulator
RG60_RS19235	COG0531	amino acid
RG60_RS19240	COG1982	Orn Lys Arg decarboxylase major
RG60_RS19245	COG3104	oligopeptide transport
RG60_RS19250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG60_RS19270	COG2388	GCN5-related N-acetyl-transferase
RG60_RS19275	COG3592	Divergent 4Fe-4S mono-cluster
RG60_RS19280	COG3290	protein histidine kinase activity
RG60_RS19285	COG4565	transcriptional regulatory protein
RG60_RS19295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG60_RS19300	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG60_RS19300	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG60_RS19305	COG3647	Membrane
RG60_RS19310	COG2211	Major facilitator Superfamily
RG60_RS19315	COG1486	melibiose metabolic process
RG60_RS19325	COG2169	Transcriptional regulator
RG60_RS19330	COG1982	Orn Lys Arg decarboxylase major
RG60_RS19335	COG2207	Transcriptional regulator
RG60_RS19340	COG0531	amino acid
RG60_RS19345	COG2194	sulfuric ester hydrolase activity
RG60_RS19350	COG0745	RESPONSE REGULATOR receiver
RG60_RS19355	COG0642	Histidine kinase
RG60_RS19365	COG0477	Major facilitator Superfamily
RG60_RS19385	COG2824	Alkylphosphonate utilization operon protein PhnA
RG60_RS19390	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RG60_RS19400	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RG60_RS19405	COG3639	organic phosphonate transmembrane transporter activity
RG60_RS19410	COG2188	Transcriptional regulator
RG60_RS19415	COG3624	Phosphonate C-P lyase system protein PhnG
RG60_RS19420	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RG60_RS19425	COG3626	phosphonate metabolism
RG60_RS19430	COG3627	carbon phosphorus lyase activity
RG60_RS19435	COG4107	phosphonate C-P lyase system protein PhnK
RG60_RS19445	COG4778	phosphonate C-P lyase system protein PhnL
RG60_RS19450	COG3454	Phosphonate metabolism
RG60_RS19455	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RG60_RS19460	COG0456	acetyltransferase
RG60_RS19465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RG60_RS19475	COG0698	ribose 5-phosphate isomerase
RG60_RS19480	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RG60_RS19490	COG1566	PFAM secretion protein HlyD family protein
RG60_RS19495	COG1289	transmembrane transporter activity
RG60_RS19505	COG3383	formate dehydrogenase (NAD+) activity
RG60_RS19510	COG3383	formate dehydrogenase (NAD+) activity
RG60_RS19515	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG60_RS19520	COG1301	dicarboxylic acid transport
RG60_RS19530	COG4235	cytochrome complex assembly
RG60_RS19535	COG3088	subunit of a heme lyase
RG60_RS19540	COG1138	Cytochrome C-type biogenesis protein
RG60_RS19545	COG3301	Polysulphide reductase, NrfD
RG60_RS19550	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS19555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RG60_RS19570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG60_RS19575	COG3162	membrane
RG60_RS19585	COG1357	PFAM Pentapeptide repeats (8 copies)
RG60_RS19590	COG0025	NhaP-type Na H and K H
RG60_RS19595	COG2252	PERMEase
RG60_RS19615	COG0789	Transcriptional regulator
RG60_RS19620	COG2207	Transcriptional regulator
RG60_RS19625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG60_RS19640	COG0629	single-stranded DNA binding
RG60_RS19645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RG60_RS19650	COG2315	Protein conserved in bacteria
RG60_RS19655	COG0432	Pfam Uncharacterised protein family UPF0047
RG60_RS19660	COG3700	Belongs to the class B bacterial acid phosphatase family
RG60_RS19670	COG1448	Aminotransferase
RG60_RS19675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG60_RS19680	COG0305	Participates in initiation and elongation during chromosome replication
RG60_RS19685	COG0604	alcohol dehydrogenase
RG60_RS19695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG60_RS19710	COG0735	belongs to the Fur family
RG60_RS19715	COG3237	CsbD-like
RG60_RS19720	COG0534	Mate efflux family protein
RG60_RS19730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RG60_RS19755	COG1357	PFAM Pentapeptide repeats (8 copies)
RG60_RS19775	COG3842	ATPase activity
RG60_RS19785	COG2182	Extracellular solute-binding protein
RG60_RS19790	COG1175	transmembrane transport
RG60_RS19795	COG3833	ABC-type maltose transport systems, permease component
RG60_RS19800	COG0477	Major facilitator Superfamily
RG60_RS19800	COG2814	Major facilitator Superfamily
RG60_RS19815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG60_RS19845	COG0527	aspartate kinase activity
RG60_RS19850	COG0542	response to heat
RG60_RS19855	COG3541	Predicted nucleotidyltransferase
RG60_RS19870	COG1187	pseudouridine synthase activity
RG60_RS19880	COG1283	sodium-dependent phosphate transmembrane transporter activity
RG60_RS19885	COG1410	methionine synthase
RG60_RS19885	COG0646	methionine synthase
RG60_RS19890	COG1414	Transcriptional regulator
RG60_RS19915	COG2224	Isocitrate lyase
RG60_RS19920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG60_RS19930	COG0456	acetyltransferase
RG60_RS19970	COG0151	Belongs to the GarS family
RG60_RS19975	COG2204	response regulator
RG60_RS19980	COG4191	Histidine kinase
RG60_RS19990	COG3678	ATP-independent chaperone mediated protein folding
RG60_RS20005	COG3068	Protein conserved in bacteria
RG60_RS20040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG60_RS20045	COG2104	thiamine diphosphate biosynthetic process
RG60_RS20055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RG60_RS20100	COG0250	Participates in transcription elongation, termination and antitermination
RG60_RS20105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG60_RS20150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RG60_RS20150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RG60_RS20205	COG1309	transcriptional regulator
RG60_RS20220	COG0583	DNA-binding transcription factor activity
RG60_RS20235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RG60_RS20250	COG2194	sulfuric ester hydrolase activity
RG60_RS20255	COG2207	Transcriptional regulator
RG60_RS20260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS20265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG60_RS20270	COG1882	Formate acetyltransferase
RG60_RS20275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS20280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS20285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG60_RS20285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS20285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS20290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG60_RS20295	COG0371	Dehydrogenase
RG60_RS20305	COG3738	Protein conserved in bacteria
RG60_RS20310	COG0697	spore germination
RG60_RS20320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RG60_RS20330	COG0460	homoserine dehydrogenase
RG60_RS20330	COG0527	aspartate kinase activity
RG60_RS20335	COG0626	cystathionine gamma-synthase activity
RG60_RS20350	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RG60_RS20380	COG3209	COG3209 Rhs family protein
RG60_RS20390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RG60_RS20395	COG1609	Transcriptional regulator
RG60_RS20400	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG60_RS20415	COG1575	Belongs to the MenA family. Type 1 subfamily
RG60_RS20430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RG60_RS20440	COG1494	fructose-1,6-bisphosphatase
RG60_RS20450	COG0589	response to stress
RG60_RS20455	COG3691	Protein conserved in bacteria
RG60_RS20460	COG3152	Membrane
RG60_RS20485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RG60_RS20490	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS20505	COG3678	ATP-independent chaperone mediated protein folding
RG60_RS20510	COG0745	RESPONSE REGULATOR receiver
RG60_RS20515	COG2205	protein histidine kinase activity
RG60_RS20520	COG2258	MOSC domain
RG60_RS20540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG60_RS20585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS20590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS20590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG60_RS20595	COG1363	Peptidase, m42
RG60_RS20600	COG3711	transcriptional antiterminator
RG60_RS20600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS20620	COG0243	molybdopterin cofactor binding
RG60_RS20620	COG3383	formate dehydrogenase (NAD+) activity
RG60_RS20625	COG3383	formate dehydrogenase (NAD+) activity
RG60_RS20625	COG0243	molybdopterin cofactor binding
RG60_RS20630	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS20635	COG2864	formate dehydrogenase
RG60_RS20645	COG3547	Transposase (IS116 IS110 IS902 family)
RG60_RS20655	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG60_RS20660	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG60_RS20675	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RG60_RS20685	COG0456	acetyltransferase
RG60_RS20700	COG1011	Hydrolase
RG60_RS20710	COG0477	Major facilitator Superfamily
RG60_RS20720	COG1063	alcohol dehydrogenase
RG60_RS20725	COG3684	Belongs to the aldolase LacD family
RG60_RS20730	COG2084	Dehydrogenase
RG60_RS20735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG60_RS20740	COG1349	DNA-binding transcription factor activity
RG60_RS20745	COG2271	Major facilitator Superfamily
RG60_RS20750	COG1082	Xylose isomerase domain protein TIM barrel
RG60_RS20755	COG2188	Transcriptional regulator
RG60_RS20760	COG1217	gtp-binding protein TYPA
RG60_RS20770	COG0174	glutamine synthetase
RG60_RS20775	COG3852	Histidine kinase
RG60_RS20780	COG2204	response regulator
RG60_RS20790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG60_RS20810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG60_RS20810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG60_RS20820	COG0204	Acyl-transferase
RG60_RS20825	COG5339	Protein conserved in bacteria
RG60_RS20830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG60_RS20835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RG60_RS20840	COG3084	Protein conserved in bacteria
RG60_RS20845	COG0746	molybdenum cofactor guanylyltransferase activity
RG60_RS20850	COG1763	Mo-molybdopterin cofactor biosynthetic process
RG60_RS20880	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
RG60_RS20885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG60_RS20890	COG1739	Uncharacterized protein family UPF0029
RG60_RS20910	COG0543	2 iron, 2 sulfur cluster binding
RG60_RS20915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RG60_RS20920	COG0250	Participates in transcription elongation, termination and antitermination
RG60_RS20930	COG0805	protein transport
RG60_RS20935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG60_RS20940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG60_RS20950	COG3165	ubiquinone biosynthetic process from chorismate
RG60_RS20960	COG1322	Protein conserved in bacteria
RG60_RS20970	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RG60_RS20975	COG0412	Dienelactone hydrolase
RG60_RS20985	COG0583	DNA-binding transcription factor activity
RG60_RS20990	COG0697	spore germination
RG60_RS20995	COG0561	phosphatase activity
RG60_RS21000	COG2267	carboxylic ester hydrolase activity
RG60_RS21005	COG1280	lysine exporter protein (LysE YggA)
RG60_RS21010	COG1280	lysine exporter protein (LysE YggA)
RG60_RS21015	COG0514	ATP-dependent DNA helicase (RecQ)
RG60_RS21020	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RG60_RS21025	COG2050	protein possibly involved in aromatic compounds catabolism
RG60_RS21030	COG2962	Rard protein
RG60_RS21060	COG0598	Magnesium transport protein CorA
RG60_RS21070	COG3698	Phosphodiester glycosidase
RG60_RS21075	COG0210	DNA helicase
RG60_RS21080	COG1011	Hydrolase
RG60_RS21090	COG3159	Protein conserved in bacteria
RG60_RS21100	COG5567	small periplasmic lipoprotein
RG60_RS21115	COG3072	Adenylate cyclase
RG60_RS21130	COG1587	Uroporphyrinogen-III synthase
RG60_RS21135	COG2959	enzyme of heme biosynthesis
RG60_RS21140	COG3071	HemY protein
RG60_RS21145	COG3119	arylsulfatase activity
RG60_RS21150	COG0641	radical SAM
RG60_RS21175	COG1113	amino acid transport
RG60_RS21195	COG2244	polysaccharide biosynthetic process
RG60_RS21200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RG60_RS21205	COG0456	acetyltransferase
RG60_RS21210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG60_RS21215	COG1088	dTDP-glucose 4,6-dehydratase activity
RG60_RS21220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RG60_RS21225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RG60_RS21230	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG60_RS21235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RG60_RS21245	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RG60_RS21255	COG3118	belongs to the thioredoxin family
RG60_RS21275	COG0210	DNA helicase
RG60_RS21280	COG3692	DNA binding
RG60_RS21285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG60_RS21295	COG0583	DNA-binding transcription factor activity
RG60_RS21300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG60_RS21310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG60_RS21315	COG3978	acetolactate synthase activity
RG60_RS21330	COG0606	chelatase, subunit chli
RG60_RS21335	COG3085	chromosome segregation
RG60_RS21380	COG2186	Transcriptional regulator
RG60_RS21385	COG0477	Major facilitator Superfamily
RG60_RS21390	COG1609	Transcriptional regulator
RG60_RS21395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG60_RS21400	COG1879	ABC-type sugar transport system periplasmic component
RG60_RS21405	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG60_RS21410	COG1129	ABC transporter
RG60_RS21440	COG1522	sequence-specific DNA binding
RG60_RS21445	COG0716	FMN binding
RG60_RS21460	COG3312	ion transport
RG60_RS21515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RG60_RS21530	COG3188	usher protein
RG60_RS21540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG60_RS21545	COG0573	inorganic phosphate transmembrane transporter activity
RG60_RS21550	COG0581	inorganic phosphate transmembrane transporter activity
RG60_RS21555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RG60_RS21560	COG0704	Plays a role in the regulation of phosphate uptake
RG60_RS21565	COG3711	transcriptional antiterminator
RG60_RS21570	COG2190	(PTS) system
RG60_RS21570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS21570	COG1263	PTS System
RG60_RS21575	COG2723	6-phospho-beta-galactosidase activity
RG60_RS21585	COG2382	esterase
RG60_RS21590	COG0363	glucosamine-6-phosphate deaminase activity
RG60_RS21595	COG3196	Protein conserved in bacteria
RG60_RS21605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG60_RS21610	COG2252	PERMEase
RG60_RS21615	COG0431	NADPH-dependent FMN reductase
RG60_RS21620	COG2091	lysine biosynthetic process via aminoadipic acid
RG60_RS21635	COG0814	amino acid
RG60_RS21685	COG0592	DNA-directed DNA polymerase activity
RG60_RS21695	COG0187	DNA topoisomerase II activity
RG60_RS21700	COG3753	Protein conserved in bacteria
RG60_RS21705	COG0561	phosphatase activity
RG60_RS21715	COG2186	Transcriptional regulator
RG60_RS21720	COG3734	2-keto-3-deoxy-galactonokinase
RG60_RS21725	COG0800	Aldolase
RG60_RS21735	COG2271	Major facilitator Superfamily
RG60_RS21745	COG0823	Involved in the tonB-independent uptake of proteins
RG60_RS21750	COG5645	(Lipo)protein
RG60_RS21770	COG2188	Transcriptional regulator
RG60_RS21790	COG2207	Transcriptional regulator
RG60_RS21795	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG60_RS21800	COG3119	arylsulfatase activity
RG60_RS21810	COG2149	membrane
RG60_RS21820	COG0641	radical SAM
RG60_RS21860	COG0028	Belongs to the TPP enzyme family
RG60_RS21865	COG0440	acetolactate synthase activity
RG60_RS21870	COG2197	response regulator
RG60_RS21875	COG3851	Histidine kinase
RG60_RS21880	COG2271	Major facilitator Superfamily
RG60_RS21885	COG2271	Major facilitator Superfamily
RG60_RS21895	COG2252	PERMEase
RG60_RS21930	COG1464	Belongs to the NlpA lipoprotein family
RG60_RS21940	COG2814	Major facilitator Superfamily
RG60_RS21975	COG2003	Belongs to the UPF0758 family
RG60_RS21995	COG3468	outer membrane autotransporter barrel domain protein
RG60_RS22025	COG3436	PFAM IS66 Orf2 family protein
RG60_RS22035	COG4372	Transposase
RG60_RS22145	COG4372	Transposase
RG60_RS22150	COG3436	PFAM IS66 Orf2 family protein
RG60_RS22160	COG2963	transposase activity
RG60_RS22165	COG2801	Transposase and inactivated derivatives
RG60_RS22175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG60_RS22185	COG0583	DNA-binding transcription factor activity
RG60_RS22200	COG2801	Transposase and inactivated derivatives
RG60_RS22270	COG4372	Transposase
RG60_RS22275	COG3436	PFAM IS66 Orf2 family protein
RG60_RS22290	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RG60_RS22290	COG5295	Hep Hag repeat protein
RG60_RS22330	COG2207	Transcriptional regulator
RG60_RS22380	COG0582	viral genome integration into host DNA
RG60_RS22385	COG0582	viral genome integration into host DNA
RG60_RS22395	COG2211	Major facilitator Superfamily
RG60_RS22400	COG1501	Belongs to the glycosyl hydrolase 31 family
RG60_RS22405	COG2982	Protein involved in outer membrane biogenesis
RG60_RS22410	COG2233	PERMEase
RG60_RS22415	COG0786	glutamate:sodium symporter activity
RG60_RS22425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RG60_RS22430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG60_RS22435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG60_RS22445	COG0194	GDP metabolic process
RG60_RS22455	COG2860	membrane
RG60_RS22460	COG3645	SOS response
RG60_RS22465	COG1561	YicC-like family, N-terminal region
RG60_RS22495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RG60_RS22525	COG1519	Transferase
RG60_RS22530	COG0859	PFAM glycosyl transferase family 9
RG60_RS22535	COG0438	transferase activity, transferring glycosyl groups
RG60_RS22540	COG0515	serine threonine protein kinase
RG60_RS22550	COG3642	lipopolysaccharide core region biosynthetic process
RG60_RS22570	COG0859	PFAM glycosyl transferase family 9
RG60_RS22575	COG0859	PFAM glycosyl transferase family 9
RG60_RS22590	COG0156	8-amino-7-oxononanoate synthase activity
RG60_RS22600	COG1216	Glycosyl transferase, family 2
RG60_RS22605	COG2861	carbohydrate metabolic process
RG60_RS22610	COG4942	peptidase
RG60_RS22625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG60_RS22630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG60_RS22645	COG1045	serine acetyltransferase
RG60_RS22650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RG60_RS22660	COG2186	Transcriptional regulator
RG60_RS22665	COG1620	l-lactate permease
RG60_RS22700	COG3722	fumarate hydratase activity
RG60_RS22710	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS22710	COG2213	PTS system mannitol-specific
RG60_RS22720	COG1566	PFAM secretion protein HlyD family protein
RG60_RS22745	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG60_RS22750	COG3209	COG3209 Rhs family protein
RG60_RS22755	COG1413	lyase activity
RG60_RS22765	COG3209	COG3209 Rhs family protein
RG60_RS22770	COG0625	glutathione transferase activity
RG60_RS22780	COG3276	selenocysteine insertion sequence binding
RG60_RS22785	COG1454	alcohol dehydrogenase
RG60_RS22790	COG1012	belongs to the aldehyde dehydrogenase family
RG60_RS22805	COG1566	PFAM secretion protein HlyD family protein
RG60_RS22810	COG0583	DNA-binding transcription factor activity
RG60_RS22815	COG3713	MltA-interacting MipA family protein
RG60_RS22825	COG2211	Major facilitator Superfamily
RG60_RS22835	COG0235	Class ii aldolase
RG60_RS22840	COG3623	hexulose-6-phosphate isomerase
RG60_RS22845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RG60_RS22850	COG1070	Carbohydrate kinase
RG60_RS22855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG60_RS22860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RG60_RS22865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG60_RS22870	COG2731	YhcH YjgK YiaL family protein
RG60_RS22880	COG1414	Transcriptional regulator
RG60_RS22885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG60_RS22890	COG3977	Valine--pyruvate aminotransferase
RG60_RS22895	COG0366	Alpha amylase catalytic
RG60_RS22900	COG2992	FlgJ-related protein
RG60_RS22905	COG1609	Transcriptional regulator
RG60_RS22905	COG2207	Transcriptional regulator
RG60_RS22910	COG4214	carbohydrate transport
RG60_RS22915	COG1129	ABC transporter
RG60_RS22920	COG4213	ABC transporter substrate-binding protein
RG60_RS22930	COG1070	Carbohydrate kinase
RG60_RS22935	COG4682	membrane
RG60_RS22940	COG4682	membrane
RG60_RS22945	COG3274	enterobacterial common antigen metabolic process
RG60_RS22970	COG1278	Cold shock
RG60_RS22975	COG2944	sequence-specific DNA binding
RG60_RS22990	COG2885	chlorophyll binding
RG60_RS22995	COG0243	molybdopterin cofactor binding
RG60_RS23000	COG0456	acetyltransferase
RG60_RS23005	COG2818	Glycosylase
RG60_RS23010	COG5571	outer membrane autotransporter
RG60_RS23020	COG2223	nitrite transmembrane transporter activity
RG60_RS23050	COG2194	sulfuric ester hydrolase activity
RG60_RS23070	COG0747	negative chemotaxis
RG60_RS23080	COG0601	transmembrane transport
RG60_RS23085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG60_RS23090	COG0444	Belongs to the ABC transporter superfamily
RG60_RS23095	COG4608	Belongs to the ABC transporter superfamily
RG60_RS23100	COG0814	amino acid
RG60_RS23135	COG2194	sulfuric ester hydrolase activity
RG60_RS23160	COG1215	transferase activity, transferring glycosyl groups
RG60_RS23165	COG1215	transferase activity, transferring glycosyl groups
RG60_RS23170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RG60_RS23175	COG3118	belongs to the thioredoxin family
RG60_RS23175	COG0457	Tetratricopeptide repeat
RG60_RS23180	COG2200	EAL domain
RG60_RS23180	COG2199	diguanylate cyclase activity
RG60_RS23200	COG0612	Peptidase, M16
RG60_RS23215	COG2200	EAL domain
RG60_RS23220	COG2982	Protein involved in outer membrane biogenesis
RG60_RS23225	COG0477	Major facilitator Superfamily
RG60_RS23230	COG1295	ribonuclease BN
RG60_RS23235	COG0583	DNA-binding transcription factor activity
RG60_RS23240	COG2197	response regulator
RG60_RS23250	COG1858	cytochrome C peroxidase
RG60_RS23255	COG0076	glutamate decarboxylase activity
RG60_RS23265	COG2207	Transcriptional regulator
RG60_RS23275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG60_RS23280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS23290	COG2771	luxR family
RG60_RS23295	COG3247	response to pH
RG60_RS23310	COG1285	pathogenesis
RG60_RS23315	COG2197	response regulator
RG60_RS23325	COG3065	identical protein binding
RG60_RS23345	COG1393	Belongs to the ArsC family
RG60_RS23350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG60_RS23355	COG0640	Transcriptional regulator
RG60_RS23370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG60_RS23375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RG60_RS23380	COG0339	signal peptide processing
RG60_RS23390	COG3104	oligopeptide transport
RG60_RS23400	COG0589	response to stress
RG60_RS23410	COG0306	phosphate transporter
RG60_RS23415	COG2081	HI0933 family
RG60_RS23445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS23450	COG1129	ABC transporter
RG60_RS23450	COG0842	Transport permease protein
RG60_RS23455	COG0842	Transport permease protein
RG60_RS23480	COG0444	Belongs to the ABC transporter superfamily
RG60_RS23485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG60_RS23490	COG0601	transmembrane transport
RG60_RS23495	COG0747	negative chemotaxis
RG60_RS23500	COG2091	lysine biosynthetic process via aminoadipic acid
RG60_RS23505	COG0628	permease
RG60_RS23520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RG60_RS23535	COG3714	YhhN family
RG60_RS23545	COG3776	membrane
RG60_RS23550	COG0742	ribosomal rna small subunit methyltransferase
RG60_RS23555	COG0552	protein localization to endoplasmic reticulum
RG60_RS23560	COG2884	Cell division ATP-binding protein ftsE
RG60_RS23565	COG2177	Part of the ABC transporter FtsEX involved in
RG60_RS23570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG60_RS23575	COG0683	leucine binding
RG60_RS23580	COG0456	acetyltransferase
RG60_RS23590	COG0683	leucine binding
RG60_RS23595	COG0559	Belongs to the binding-protein-dependent transport system permease family
RG60_RS23600	COG4177	L-phenylalanine transmembrane transporter activity
RG60_RS23605	COG0411	ABC transporter
RG60_RS23610	COG0410	ABC transporter
RG60_RS23620	COG1653	transport
RG60_RS23625	COG1175	transmembrane transport
RG60_RS23630	COG0395	ABC-type sugar transport system, permease component
RG60_RS23635	COG3842	ATPase activity
RG60_RS23640	COG0584	glycerophosphoryl diester phosphodiesterase
RG60_RS23650	COG0405	Gamma-glutamyltransferase
RG60_RS23660	COG2801	Transposase and inactivated derivatives
RG60_RS23680	COG3157	Type VI secretion system effector, Hcp
RG60_RS23685	COG1247	-acetyltransferase
RG60_RS23690	COG0673	inositol 2-dehydrogenase activity
RG60_RS23695	COG1741	Belongs to the pirin family
RG60_RS23700	COG1609	Transcriptional regulator
RG60_RS23705	COG3265	gluconokinase activity
RG60_RS23710	COG2610	gluconate transmembrane transporter activity
RG60_RS23715	COG2095	MarC family integral membrane protein
RG60_RS23720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG60_RS23745	COG0058	SHG alpha-glucan phosphorylase activity
RG60_RS23750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG60_RS23770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG60_RS23785	COG1349	DNA-binding transcription factor activity
RG60_RS23790	COG4650	regulator
RG60_RS23795	COG1690	Belongs to the RtcB family
RG60_RS23810	COG0058	SHG alpha-glucan phosphorylase activity
RG60_RS23815	COG1640	4-alpha-glucanotransferase
RG60_RS23820	COG2610	gluconate transmembrane transporter activity
RG60_RS23855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RG60_RS23860	COG1918	ferrous iron import across plasma membrane
RG60_RS23870	COG2183	response to ionizing radiation
RG60_RS23875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG60_RS23905	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG60_RS23915	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RG60_RS23920	COG1011	Hydrolase
RG60_RS23930	COG0494	nUDIX hydrolase
RG60_RS23935	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RG60_RS23940	COG4972	Pilus assembly protein
RG60_RS23945	COG3166	PFAM Fimbrial assembly family protein
RG60_RS23960	COG4796	Type ii and iii secretion system protein
RG60_RS23980	COG3266	domain, Protein
RG60_RS23985	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RG60_RS23990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG60_RS23995	COG0546	phosphoglycolate phosphatase activity
RG60_RS24000	COG0180	Tryptophanyl-tRNA synthetase
RG60_RS24005	COG2188	Transcriptional regulator
RG60_RS24015	COG3457	Alanine racemase
RG60_RS24020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RG60_RS24025	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RG60_RS24040	COG0626	cystathionine gamma-synthase activity
RG60_RS24045	COG2188	Transcriptional regulator
RG60_RS24055	COG1082	Xylose isomerase domain protein TIM barrel
RG60_RS24060	COG1082	Xylose isomerase domain protein TIM barrel
RG60_RS24065	COG2222	sugar isomerase
RG60_RS24070	COG0531	amino acid
RG60_RS24085	COG2116	formate transmembrane transporter activity
RG60_RS24090	COG2146	nitrite reductase [NAD(P)H] activity
RG60_RS24095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG60_RS24105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG60_RS24115	COG2184	nucleotidyltransferase activity
RG60_RS24120	COG0512	Glutamine amidotransferase of anthranilate synthase
RG60_RS24125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RG60_RS24130	COG1289	transmembrane transporter activity
RG60_RS24135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG60_RS24145	COG1765	OsmC-like protein
RG60_RS24150	COG3954	Phosphoribulokinase
RG60_RS24160	COG0429	hydrolase of the alpha beta-hydrolase fold
RG60_RS24165	COG0488	(ABC) transporter
RG60_RS24185	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RG60_RS24190	COG1047	Peptidyl-prolyl cis-trans
RG60_RS24200	COG0545	Peptidyl-prolyl cis-trans isomerase
RG60_RS24205	COG2964	Protein conserved in bacteria
RG60_RS24285	COG0089	rRNA binding
RG60_RS24375	COG0201	protein transport
RG60_RS24415	COG0789	Transcriptional regulator
RG60_RS24420	COG3036	rescue of stalled ribosome
RG60_RS24430	COG0569	domain protein
RG60_RS24450	COG0758	DNA mediated transformation
RG60_RS24460	COG0551	DNA topoisomerase type I activity
RG60_RS24480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG60_RS24520	COG1126	abc transporter atp-binding protein
RG60_RS24525	COG0765	amino acid transport
RG60_RS24530	COG4597	amino acid ABC transporter
RG60_RS24535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG60_RS24550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG60_RS24555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG60_RS24565	COG1309	transcriptional regulator
RG60_RS24575	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RG60_RS24585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG60_RS24595	COG4145	pantothenate transmembrane transporter activity
RG60_RS24600	COG3924	membrane
RG60_RS24605	COG0439	Biotin carboxylase
RG60_RS24610	COG0511	ligase activity, forming carbon-carbon bonds
RG60_RS24625	COG0604	alcohol dehydrogenase
RG60_RS24630	COG2200	EAL domain
RG60_RS24630	COG2199	diguanylate cyclase activity
RG60_RS24645	COG1077	Cell shape determining protein MreB Mrl
RG60_RS24650	COG1792	Involved in formation and maintenance of cell shape
RG60_RS24655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RG60_RS24665	COG1530	ribonuclease E activity
RG60_RS24670	COG3164	Protein of unknown function
RG60_RS24680	COG0312	modulator of DNA gyrase
RG60_RS24685	COG0583	DNA-binding transcription factor activity
RG60_RS24705	COG2732	(Barnase) inhibitor
RG60_RS24725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG60_RS24730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG60_RS24735	COG3105	Protein conserved in bacteria
RG60_RS24740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RG60_RS24755	COG0625	glutathione transferase activity
RG60_RS24760	COG2969	positive regulation of protein catabolic process
RG60_RS24765	COG3069	C4-dicarboxylate transmembrane transporter activity
RG60_RS24800	COG2731	YhcH YjgK YiaL family protein
RG60_RS24810	COG4804	nuclease activity
RG60_RS24815	COG0493	'glutamate synthase
RG60_RS24820	COG0067	glutamate synthase
RG60_RS24820	COG0069	glutamate synthase activity
RG60_RS24820	COG0070	glutamate synthase
RG60_RS24830	COG1242	4 iron, 4 sulfur cluster binding
RG60_RS24835	COG2198	Histidine kinase
RG60_RS24835	COG5002	protein histidine kinase activity
RG60_RS24835	COG0784	Response regulator, receiver
RG60_RS24840	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RG60_RS24850	COG0515	serine threonine protein kinase
RG60_RS24855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS24870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG60_RS24875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RG60_RS24880	COG1137	ATPase activity
RG60_RS24885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RG60_RS24890	COG3117	lipopolysaccharide transmembrane transporter activity
RG60_RS24895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RG60_RS24900	COG0517	IMP dehydrogenase activity
RG60_RS24900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG60_RS24905	COG0530	calcium, potassium:sodium antiporter activity
RG60_RS24910	COG1127	ABC transporter
RG60_RS24915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RG60_RS24920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG60_RS24925	COG2854	intermembrane phospholipid transfer
RG60_RS24930	COG3113	response to antibiotic
RG60_RS24935	COG5007	Belongs to the BolA IbaG family
RG60_RS24945	COG3423	Transcriptional regulator
RG60_RS24950	COG0142	geranyltranstransferase activity
RG60_RS24965	COG0697	spore germination
RG60_RS24975	COG2027	D-alanyl-D-alanine carboxypeptidase
RG60_RS24980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG60_RS24985	COG1534	Rna-binding protein
RG60_RS24995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG60_RS25000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RG60_RS25010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG60_RS25025	COG2194	sulfuric ester hydrolase activity
RG60_RS25045	COG0195	Participates in both transcription termination and antitermination
RG60_RS25085	COG0513	Belongs to the DEAD box helicase family
RG60_RS25095	COG0814	amino acid
RG60_RS25100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RG60_RS25110	COG0826	peptidase U32
RG60_RS25115	COG0826	peptidase U32
RG60_RS25120	COG3154	lipid carrier protein
RG60_RS25125	COG3153	acetyltransferase
RG60_RS25140	COG0693	protein deglycase activity
RG60_RS25145	COG0702	epimerase
RG60_RS25150	COG0701	Predicted permease
RG60_RS25155	COG2823	Periplasmic or secreted lipoprotein
RG60_RS25175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RG60_RS25180	COG3539	Fimbrial protein
RG60_RS25185	COG3188	usher protein
RG60_RS25190	COG3121	Chaperone
RG60_RS25195	COG3539	Fimbrial protein
RG60_RS25200	COG0363	glucosamine-6-phosphate deaminase activity
RG60_RS25205	COG3716	PTS system mannose fructose sorbose family IID component
RG60_RS25210	COG3715	PTS system
RG60_RS25215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS25225	COG2222	sugar isomerase
RG60_RS25230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG60_RS25235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG60_RS25240	COG3716	PTS system mannose fructose sorbose family IID component
RG60_RS25250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG60_RS25265	COG1349	DNA-binding transcription factor activity
RG60_RS25275	COG2002	toxin-antitoxin pair type II binding
RG60_RS25280	COG2721	sulfolactate sulfo-lyase activity
RG60_RS25285	COG2271	Major facilitator Superfamily
RG60_RS25295	COG2084	Dehydrogenase
RG60_RS25300	COG1929	Belongs to the glycerate kinase type-1 family
RG60_RS25330	COG0583	DNA-binding transcription factor activity
RG60_RS25335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG60_RS25345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG60_RS25350	COG1882	Formate acetyltransferase
RG60_RS25355	COG0251	oxidation-reduction process
RG60_RS25360	COG1760	l-serine dehydratase
RG60_RS25365	COG0814	amino acid
RG60_RS25380	COG1741	Belongs to the pirin family
RG60_RS25385	COG0583	DNA-binding transcription factor activity
RG60_RS25395	COG3152	Membrane
RG60_RS25400	COG3152	Membrane
RG60_RS25405	COG0435	Glutathione S-transferase
RG60_RS25410	COG2259	Doxx family
RG60_RS25420	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
RG60_RS25425	COG4575	ribosome binding
RG60_RS25430	COG1422	Protein of unknown function (DUF1090)
RG60_RS25440	COG0586	Pfam SNARE associated Golgi protein
RG60_RS25445	COG2186	Transcriptional regulator
RG60_RS25470	COG2271	Major facilitator Superfamily
RG60_RS25480	COG2721	sulfolactate sulfo-lyase activity
RG60_RS25490	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RG60_RS25495	COG0861	Integral membrane protein TerC family
RG60_RS25500	COG0673	inositol 2-dehydrogenase activity
RG60_RS25505	COG2949	membrane
RG60_RS25510	COG1451	nucleotide metabolic process
RG60_RS25520	COG4680	protein conserved in bacteria
RG60_RS25525	COG5499	transcription regulator containing HTH domain
RG60_RS25530	COG0446	pyridine nucleotide-disulphide oxidoreductase
RG60_RS25530	COG1902	pentaerythritol trinitrate reductase activity
RG60_RS25535	COG3408	Glycogen debranching enzyme
RG60_RS25535	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RG60_RS25545	COG0531	amino acid
RG60_RS25550	COG2731	YhcH YjgK YiaL family protein
RG60_RS25555	COG3250	beta-galactosidase activity
RG60_RS25560	COG1609	Transcriptional regulator
RG60_RS25570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG60_RS25585	COG0840	transmembrane signaling receptor activity
RG60_RS25590	COG1695	Transcriptional regulator
RG60_RS25595	COG2375	cellular response to nickel ion
RG60_RS25610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG60_RS25620	COG0358	DNA primase activity
RG60_RS25625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RG60_RS25645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG60_RS25655	COG0583	DNA-binding transcription factor activity
RG60_RS25665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG60_RS25680	COG4991	sh3 domain protein
RG60_RS25690	COG3025	triphosphatase activity
RG60_RS25715	COG2268	Band 7 protein
RG60_RS25720	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG60_RS25730	COG3539	Fimbrial protein
RG60_RS25735	COG3121	Chaperone
RG60_RS25740	COG3188	usher protein
RG60_RS25745	COG3539	Fimbrial protein
RG60_RS25750	COG2960	long-chain fatty acid transporting porin activity
RG60_RS25770	COG3384	dioxygenase
RG60_RS25775	COG0754	glutathionylspermidine amidase activity
RG60_RS25790	COG1538	Outer membrane efflux protein
RG60_RS25795	COG0494	nUDIX hydrolase
RG60_RS25800	COG3151	Protein conserved in bacteria
RG60_RS25805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RG60_RS25810	COG3150	esterase
RG60_RS25815	COG0187	DNA topoisomerase II activity
RG60_RS25820	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RG60_RS25825	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG60_RS25835	COG0642	Histidine kinase
RG60_RS25840	COG0745	RESPONSE REGULATOR receiver
RG60_RS25845	COG3111	PFAM Bacterial OB fold (BOF) protein
RG60_RS25850	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG60_RS25860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG60_RS25870	COG0204	Acyl-transferase
RG60_RS25875	COG2132	Multicopper oxidase
RG60_RS25880	COG1032	radical SAM domain protein
RG60_RS25885	COG4238	major outer membrane lipoprotein
RG60_RS25895	COG0656	L-ascorbic acid biosynthetic process
RG60_RS25900	COG1979	alcohol dehydrogenase
RG60_RS25910	COG2207	Transcriptional regulator
RG60_RS25915	COG0586	Pfam SNARE associated Golgi protein
RG60_RS25920	COG0626	cystathionine gamma-synthase activity
RG60_RS25930	COG0811	peptide transport
RG60_RS25935	COG0848	biopolymer transport protein
RG60_RS25945	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS25955	COG0667	Aldo Keto reductase
RG60_RS25975	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG60_RS25980	COG0437	4 iron, 4 sulfur cluster binding
RG60_RS25985	COG5557	Pfam Polysulphide reductase, NrfD
RG60_RS25990	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG60_RS25995	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG60_RS26000	COG1773	rubredoxin
RG60_RS26010	COG0298	carbon dioxide binding
RG60_RS26015	COG0625	glutathione transferase activity
RG60_RS26020	COG0754	glutathionylspermidine amidase activity
RG60_RS26025	COG0306	phosphate transporter
RG60_RS26030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG60_RS26035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG60_RS26040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG60_RS26045	COG2244	polysaccharide biosynthetic process
RG60_RS26055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG60_RS26060	COG0795	lipopolysaccharide-transporting ATPase activity
RG60_RS26070	COG0156	8-amino-7-oxononanoate synthase activity
RG60_RS26075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RG60_RS26085	COG0318	PFAM AMP-dependent synthetase and ligase
RG60_RS26095	COG0456	acetyltransferase
RG60_RS26100	COG2186	Transcriptional regulator
RG60_RS26105	COG0277	FAD linked oxidase domain protein
RG60_RS26110	COG0277	FAD linked oxidase domain protein
RG60_RS26115	COG0247	lactate metabolic process
RG60_RS26120	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RG60_RS26125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG60_RS26130	COG1620	l-lactate permease
RG60_RS26145	COG3064	Membrane
RG60_RS26170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG60_RS26175	COG1459	type II secretion system
RG60_RS26180	COG2165	general secretion pathway protein
RG60_RS26210	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG60_RS26325	COG2831	hemolysin activation secretion protein
RG60_RS26330	COG2831	hemolysin activation secretion protein
RG60_RS26350	COG3210	domain, Protein
RG60_RS26480	COG3969	phosphoadenosine phosphosulfate
RG60_RS26760	COG5295	Hep Hag repeat protein
RG60_RS26760	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RG60_RS26990	COG3321	synthase
RG60_RS26990	COG1028	Short-chain dehydrogenase reductase Sdr
RG60_RS26990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG60_RS26990	COG0318	PFAM AMP-dependent synthetase and ligase
RG60_RS26990	COG0300	oxidoreductase activity
RG60_RS27105	COG1982	Orn Lys Arg decarboxylase major
RG60_RS27335	COG0582	viral genome integration into host DNA
RG60_RS27685	COG1201	RNA secondary structure unwinding
RG60_RS27920	COG3468	outer membrane autotransporter barrel domain protein