locus-tag class description EPG46_RS00035 ENOG4105CV8 reductase EPG46_RS00040 ENOG4105HEI LysR family (Transcriptional regulator EPG46_RS00055 ENOG4105E9H Lytic Murein transglycosylase EPG46_RS00060 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EPG46_RS00065 ENOG4105D1A Methyltransferase EPG46_RS00075 ENOG4107RZZ dna polymerase iii epsilon subunit EPG46_RS00085 ENOG410600K aminopeptidase EPG46_RS00100 ENOG4105GMB type VI secretion system effector, hcp1 family EPG46_RS00125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EPG46_RS00180 ENOG4108WC9 type VI secretion system effector, hcp1 family EPG46_RS00185 ENOG4105CS6 Rhs element vgr protein EPG46_RS00220 ENOG410600T transposase EPG46_RS00225 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EPG46_RS00230 ENOG4108WN0 inhibitor of vertebrate lysozyme EPG46_RS00235 ENOG4107QPN acyl-Coa dehydrogenase EPG46_RS00245 ENOG4105E7A Glutamine amidotransferase EPG46_RS00250 ENOG4105F7V ErfK ybiS ycfS ynhG family protein EPG46_RS00255 ENOG4105VXN addiction module toxin, RelE StbE family EPG46_RS00260 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression EPG46_RS00265 ENOG4108YS0 lipoprotein YafL EPG46_RS00270 ENOG4108UK5 Transposase EPG46_RS00285 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EPG46_RS00290 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system EPG46_RS00295 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome EPG46_RS00300 ENOG4108HYG acetyltransferase EPG46_RS00310 ENOG4108S2Y peptide Chain Release factor EPG46_RS00315 ENOG4105CIN aminoacyl-histidine dipeptidase EPG46_RS00325 ENOG4105V1F Fermentation respiration switch protein EPG46_RS00335 ENOG4105FCK Membrane EPG46_RS00345 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EPG46_RS00370 ENOG4108P8R EPG46_RS00375 ENOG4108P8R EPG46_RS00430 ENOG4105C57 major facilitator superfamily EPG46_RS00435 ENOG4105D64 Mechanosensitive ion channel EPG46_RS00515 ENOG4105C5Y PTS System EPG46_RS00530 ENOG4105EKQ RNA-directed DNA polymerase EPG46_RS00605 ENOG4105F4K antigen 43 EPG46_RS00610 ENOG4106H6R UPF0380 protein EPG46_RS00620 ENOG4106549 Antirestriction protein EPG46_RS00625 ENOG4108YGG dna repair protein EPG46_RS00640 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles EPG46_RS00685 ENOG4107XAN XdhC and CoxI family EPG46_RS00690 ENOG4105C7W Xanthine dehydrogenase EPG46_RS00695 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding EPG46_RS00700 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit EPG46_RS00705 ENOG4105R3P Inner membrane protein yagU EPG46_RS00710 ENOG4105PI0 Ferredoxin EPG46_RS00715 ENOG4108UD7 cell wall organization EPG46_RS00720 ENOG4106PYX Receptor EPG46_RS00725 ENOG4108N3D putative enzyme EPG46_RS00735 ENOG4108GWT fimbrillin MatB EPG46_RS00745 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon EPG46_RS00785 ENOG4108KBJ Inner membrane protein YkgB EPG46_RS00790 ENOG41066GK UPF0379 protein ykgI EPG46_RS00795 ENOG4107QN2 dihydrolipoyl dehydrogenase EPG46_RS00800 ENOG4108K01 transcriptional regulator EPG46_RS00805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EPG46_RS00810 ENOG4107QR9 Iron-sulfur cluster binding protein EPG46_RS00815 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) EPG46_RS00825 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EPG46_RS00830 ENOG4105C26 Dehydrogenase EPG46_RS00835 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EPG46_RS00840 ENOG4105C94 Transporter EPG46_RS00850 ENOG4105BZU Histidine kinase EPG46_RS00855 ENOG4108NUU Transcriptional regulator EPG46_RS00860 ENOG4105SZ2 membrAne EPG46_RS00865 ENOG4107SNB ankyrin repeat protein YahD EPG46_RS00870 ENOG4105N16 Protein of unknown function (DUF2877) EPG46_RS00875 ENOG4107R1Q Membrane protein FdrA EPG46_RS00880 ENOG4107REC cytoplasmic protein EPG46_RS00890 ENOG4105C5B carbamate kinase EPG46_RS00895 ENOG4105DZC cytosine deaminase EPG46_RS00900 ENOG4105DQ4 alcohol dehydrogenase EPG46_RS00915 ENOG4105E82 cytochrome subunit of dehydrogenase EPG46_RS00920 ENOG4105TDT uncharacterized protein yahO EPG46_RS00925 ENOG4108JU7 Transcriptional regulator EPG46_RS00930 ENOG4105CR4 methylisocitrate lyase EPG46_RS00935 ENOG4105BZN citrate synthase EPG46_RS00940 ENOG4105DXD 2-methylcitrate dehydratase EPG46_RS00945 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EPG46_RS00950 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin EPG46_RS00955 ENOG4105DZC cytosine deaminase EPG46_RS00960 ENOG4105DND Transcriptional regulator EPG46_RS00965 ENOG4107B2H carbonic anhydrase EPG46_RS00970 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) EPG46_RS00975 ENOG4105DJ2 Major Facilitator Superfamily EPG46_RS00980 ENOG4108UW5 maltose o-acetyltransferase EPG46_RS00985 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EPG46_RS00990 ENOG4105CNT hydrolase family 2 EPG46_RS00995 ENOG4105ETE Transcriptional regulator (LacI family EPG46_RS01000 ENOG4108K2P TRANSCRIPTIONal EPG46_RS01005 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EPG46_RS01015 ENOG4106HB6 Alpha beta hydrolase EPG46_RS01020 ENOG4105IKQ hydratase EPG46_RS01035 ENOG4108SC4 )-transporter EPG46_RS01040 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme EPG46_RS01045 ENOG4105C4W S-formylglutathione hydrolase EPG46_RS01060 ENOG4105SRB Uncharacterized protein yaiO EPG46_RS01070 ENOG4108PBI Polysaccharide metabolism EPG46_RS01075 ENOG4107W19 lmbE family EPG46_RS01080 ENOG4106FTQ Taurine ABC transporter, periplasmic EPG46_RS01090 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EPG46_RS01095 ENOG4105E2B Taurine dioxygenase EPG46_RS01100 ENOG4105D52 delta-aminolevulinic acid dehydratase EPG46_RS01110 ENOG4108PNB DNA-binding transcriptional regulator EPG46_RS01115 ENOG4107R6D beta-lactam binding protein AmpH EPG46_RS01120 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 EPG46_RS01125 ENOG4107QS8 (LipO)protein EPG46_RS01130 ENOG4105FR5 inner membrane protein YaiY EPG46_RS01135 ENOG4105UNH Membrane EPG46_RS01140 ENOG4105CPF Cell wall formation (By similarity) EPG46_RS01155 ENOG4105G6Z alkaline phosphatase EPG46_RS01160 ENOG4105VIF phosphate starvation-inducible protein EPG46_RS01165 ENOG4105BZU Histidine kinase EPG46_RS01170 ENOG4105II7 pyrroline-5-carboxylate reductase EPG46_RS01185 ENOG4105SS3 EPG46_RS01190 ENOG4105HBA AroM protein EPG46_RS01215 ENOG4105DKQ ROK family EPG46_RS01220 ENOG4105F27 Major Facilitator EPG46_RS01225 ENOG4105EYH Exonuclease EPG46_RS01230 ENOG4107RH8 nuclease SbcCD subunit D EPG46_RS01235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EPG46_RS01240 ENOG4105BZU Histidine kinase EPG46_RS01245 ENOG4105CWM branched-chain amino acid transport system II carrier protein EPG46_RS01250 ENOG4105C85 amino acid EPG46_RS01255 ENOG4107R28 alpha amylase, catalytic region EPG46_RS01260 ENOG4108ZYK Acyl carrier protein phosphodiesterase EPG46_RS01275 ENOG4105VIE preprotein translocase, subunit YajC EPG46_RS01280 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EPG46_RS01285 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EPG46_RS01290 ENOG4105N1F Hnh endonuclease EPG46_RS01295 ENOG4105DRB nucleoside-specific channel-forming protein EPG46_RS01300 ENOG4108KIC (LipO)protein EPG46_RS01310 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EPG46_RS01315 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EPG46_RS01325 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EPG46_RS01330 ENOG4108ZAI phosphatidylglycerophosphatase a EPG46_RS01335 ENOG4105CPC Aldo Keto reductase EPG46_RS01340 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EPG46_RS01345 ENOG4105CTB Polyprenyl synthetase EPG46_RS01355 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EPG46_RS01360 ENOG4107S0N DJ-1 family EPG46_RS01365 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EPG46_RS01375 ENOG4107RDB Major Facilitator EPG46_RS01385 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EPG46_RS01390 ENOG4105CCU oxidase (Subunit III) EPG46_RS01395 ENOG4105BZ9 Cytochrome C oxidase, subunit I EPG46_RS01400 ENOG4105E2S oxidase) subunit II EPG46_RS01405 ENOG4105EYM Major Facilitator superfamily EPG46_RS01410 ENOG4105IEY (LipO)protein EPG46_RS01415 ENOG4105M85 Bola protein EPG46_RS01435 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EPG46_RS01440 ENOG4105K70 DNA-binding protein EPG46_RS01445 ENOG4105EIN peptidylprolyl cis-trans isomerase EPG46_RS01450 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EPG46_RS01455 ENOG4108TGP Thioesterase superfamily protein EPG46_RS01460 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EPG46_RS01465 ENOG4108NFA extracellular solute-binding protein EPG46_RS01470 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) EPG46_RS01475 ENOG4108XM1 transcriptional regulator AsnC family EPG46_RS01480 ENOG4105BZ1 (ABC) transporter EPG46_RS01485 ENOG4105BZ1 (ABC) transporter EPG46_RS01490 ENOG4108YZA Nitrogen regulatory protein pii EPG46_RS01495 ENOG4105BZU Histidine kinase EPG46_RS01500 ENOG4105C29 acyl-CoA thioesterase EPG46_RS01505 ENOG4108MNP Glycoprotein polysaccharide metabolism EPG46_RS01510 ENOG41080UX Methyltransferase EPG46_RS01520 ENOG4105KCV RNA signal recognition particle 4.5S RNA EPG46_RS01525 ENOG41066DG (EAL) domain protein EPG46_RS01530 ENOG4105GSJ Inner membrane protein ylaC EPG46_RS01535 ENOG4108UW5 maltose o-acetyltransferase EPG46_RS01540 ENOG4105KF5 hemolysin expression-modulating protein EPG46_RS01545 ENOG4108UKR Biofilm formation regulator YbaJ EPG46_RS01550 ENOG4105BZS acriflavin resistance protein EPG46_RS01555 ENOG4105C1P efflux transporter, rnd family, mfp subunit EPG46_RS01565 ENOG4105EGS Mechanosensitive ion channel EPG46_RS01570 ENOG4106428 Protein of unknown function (DUF2496) EPG46_RS01575 ENOG4108URS primosomal replication protein n'' EPG46_RS01580 ENOG4105WD1 Membrane EPG46_RS01590 ENOG4107QMP dna polymerase iii subunits gamma and tau EPG46_RS01615 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EPG46_RS01625 ENOG4107RE1 Inosine-guanosine kinase EPG46_RS01630 ENOG4105CKD glutathione-regulated potassium-efflux system protein EPG46_RS01635 ENOG4105EU0 Major facilitator Superfamily EPG46_RS01640 ENOG4105CGH 5'-nucleotidase EPG46_RS01645 ENOG4108Z66 YbaK ebsC protein EPG46_RS01650 ENOG4105MBR gumn family EPG46_RS01655 ENOG41081XE plasmid maintenance system antidote protein, xre family EPG46_RS01660 ENOG4105C59 p-type ATPase EPG46_RS01665 ENOG4105CSV Glutaminase EPG46_RS01670 ENOG4107RY6 amino acid EPG46_RS01675 ENOG4108Z6Z Transcriptional regulator EPG46_RS01680 ENOG4105G5H Membrane EPG46_RS01685 ENOG4107QX8 SPFH domain, Band 7 family protein EPG46_RS01690 ENOG41083J0 (ABC) transporter EPG46_RS01695 ENOG4105C4B ABC transporter, permease EPG46_RS01700 ENOG4107QR8 Thioredoxin EPG46_RS01705 ENOG4105E1F short-chain dehydrogenase reductase EPG46_RS01710 ENOG4108UJV acyl-CoA thioesterase i EPG46_RS01715 ENOG4108I0Y (ABC) transporter EPG46_RS01720 ENOG4105CV6 ABC transporter, permease EPG46_RS01730 ENOG4108YXQ IS66 Orf2 family protein EPG46_RS01770 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) EPG46_RS01775 ENOG4107653 Transcriptional regulator EPG46_RS01785 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region EPG46_RS01790 ENOG41060W2 glyoxylate carboligase EPG46_RS01795 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EPG46_RS01800 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EPG46_RS01805 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EPG46_RS01810 ENOG4105CD3 dihydroorotase EPG46_RS01815 ENOG4105DTE Xanthine uracil vitamin C permease EPG46_RS01820 ENOG4105BZW Glycerate kinase EPG46_RS01835 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EPG46_RS01840 ENOG4105DG4 malate L-lactate dehydrogenase EPG46_RS01845 ENOG4107R1Q Membrane protein FdrA EPG46_RS01850 ENOG4107REC cytoplasmic protein EPG46_RS01855 ENOG4105G5A Protein of unknown function (DUF2877) EPG46_RS01860 ENOG4105C5B carbamate kinase EPG46_RS01865 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EPG46_RS01870 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EPG46_RS01880 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EPG46_RS01885 ENOG4105C8N cysteinyl-tRNA synthetase EPG46_RS01890 ENOG4105S2T inner membrane protein YbcI EPG46_RS01895 ENOG4105WQ3 Rna-binding protein EPG46_RS01900 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EPG46_RS01905 ENOG4108WDE Fimbrial protein EPG46_RS01910 ENOG4108AF8 Chaperone EPG46_RS01915 ENOG4105CW0 outer membrane usher protein EPG46_RS01920 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) EPG46_RS01925 ENOG4108ZI2 Fimbrial protein EPG46_RS01930 ENOG4108Q9V regulatoR EPG46_RS01945 ENOG4105QUW EPG46_RS01950 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit EPG46_RS01955 ENOG410802X bacteriophage n4 adsorption protein b EPG46_RS01960 ENOG4105GR3 Histidine kinase EPG46_RS01965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EPG46_RS01970 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EPG46_RS01975 ENOG410624V efflux system protein EPG46_RS01980 ENOG4105EP1 Efflux transporter rnd family, mfp subunit EPG46_RS01985 ENOG4108IJF Heavy metal efflux pump, CzcA EPG46_RS01990 ENOG4105C85 amino acid EPG46_RS01995 ENOG4105CUY Mechanosensitive ion channel EPG46_RS02000 ENOG4108RCM Nitroreductase EPG46_RS02015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EPG46_RS02020 ENOG4105CMR udp-glucose 4-epimerase EPG46_RS02040 ENOG4105CPK Glycosyl transferase (Group 1 EPG46_RS02045 ENOG4105CGN Glycosyl transferase (Group 1 EPG46_RS02050 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EPG46_RS02055 ENOG4107T8Q Glycosyl transferase (Group 1 EPG46_RS02070 ENOG4105HVQ Regulatory factor of maltose metabolism EPG46_RS02085 ENOG4108BUD transposase EPG46_RS02090 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) EPG46_RS02095 ENOG4107635 Hok Gef family protein EPG46_RS02105 ENOG4108TSE Transferase EPG46_RS02110 ENOG4107RNH Outer membrane receptor FepA EPG46_RS02120 ENOG4105E93 esterase EPG46_RS02125 ENOG41085A6 mbth domain-containing protein EPG46_RS02130 ENOG4105C0W non-ribosomal peptide synthetase EPG46_RS02135 ENOG4108QY5 Ferric enterobactin transport protein EPG46_RS02140 ENOG4105E0A ABC, transporter EPG46_RS02145 ENOG4105TVJ transport system, permease EPG46_RS02150 ENOG4105DQ5 transport system permease protein EPG46_RS02160 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein EPG46_RS02165 ENOG4105E4F Isochorismate synthase EPG46_RS02170 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EPG46_RS02175 ENOG4105WQI isochorismatase EPG46_RS02180 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EPG46_RS02185 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) EPG46_RS02190 ENOG4105D22 carbon starvation protein EPG46_RS02195 ENOG4105VCD cytoplasmic protein EPG46_RS02200 ENOG4107SCQ Iron-containing alcohol dehydrogenase EPG46_RS02205 ENOG4105CHM Aminotransferase EPG46_RS02210 ENOG4105GTN ParB Domain Protein Nuclease EPG46_RS02215 ENOG4105BZV Phosphoadenosine phosphosulfate reductase EPG46_RS02220 ENOG4105DQS Transcriptional regulator EPG46_RS02225 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase EPG46_RS02230 ENOG4105D3R alkyl hydroperoxide reductase EPG46_RS02235 ENOG4108JU3 Alkyl hydroperoxide reductase EPG46_RS02240 ENOG4108U51 Universal stress protein EPG46_RS02245 ENOG4105E2A Dehydrogenase EPG46_RS02250 ENOG4105NXH GreA GreB family elongation factor EPG46_RS02255 ENOG4105KTS ribonuclease EPG46_RS02260 ENOG4107QPK )-transporter EPG46_RS02275 ENOG4105CHY citrate lyase, alpha EPG46_RS02280 ENOG4105CI0 Citrate lyase EPG46_RS02290 ENOG4105DUA (citrate (pro-3S)-lyase ligase EPG46_RS02295 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EPG46_RS02300 ENOG4106YYS transcriptional regulatory protein EPG46_RS02305 ENOG4105CEE C4-dicarboxylate transporter EPG46_RS02310 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) EPG46_RS02330 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) EPG46_RS02340 ENOG41064T2 transcriptional regulator, lysR family EPG46_RS02355 ENOG4105DZ1 carboxypeptidase EPG46_RS02360 ENOG4105K6T rare lipoprotein A EPG46_RS02365 ENOG4105CNI cell division protein FtsW EPG46_RS02370 ENOG4105CJN penicillin-binding protein EPG46_RS02380 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EPG46_RS02385 ENOG4108TGR phosphatase EPG46_RS02395 ENOG4105DJF DNA polymerase III, delta' subunit EPG46_RS02410 ENOG4107PAI alpha helical protein EPG46_RS02415 ENOG4105EUU Sel1 domain protein repeat-containing protein EPG46_RS02420 ENOG41069CF Protein of unknown function (DUF1266) EPG46_RS02425 ENOG4105QFC Hsc56 co-chaperone of HscC EPG46_RS02430 ENOG4107JFD Sel1 repeat EPG46_RS02435 ENOG41069CF Protein of unknown function (DUF1266) EPG46_RS02440 ENOG4105QFC Hsc56 co-chaperone of HscC EPG46_RS02445 ENOG4105F7F Chaperone EPG46_RS02455 ENOG4105CDA abc transporter atp-binding protein EPG46_RS02460 ENOG4105DRP amino acid AbC transporter EPG46_RS02465 ENOG4105EAD ABC transporter EPG46_RS02470 ENOG4107RP9 extracellular solute-binding protein, family 3 EPG46_RS02475 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EPG46_RS02480 ENOG4108JU5 Magnesium and cobalt efflux protein EPG46_RS02490 ENOG4105C9A Phoh family EPG46_RS02500 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EPG46_RS02540 ENOG4105CAQ asparagine synthetase EPG46_RS02545 ENOG4105D4U had-superfamily hydrolase, subfamily iia EPG46_RS02550 ENOG4105E2R ROK family EPG46_RS02555 ENOG4105CE4 GlcNAc 6-P deacetylase EPG46_RS02565 ENOG4105CI1 PTS System EPG46_RS02580 ENOG4105GX6 (LipO)protein EPG46_RS02585 ENOG41090R7 Ferric uptake EPG46_RS02595 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) EPG46_RS02600 ENOG4105NNH LexA regulated protein EPG46_RS02605 ENOG4105EV9 Alpha Beta Hydrolase EPG46_RS02610 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) EPG46_RS02615 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 EPG46_RS02635 ENOG4105D5Q Arginine ornithine antiporter EPG46_RS02650 ENOG4105EEX Two component transcriptional regulator (Winged helix family EPG46_RS02655 ENOG4105C08 Histidine kinase EPG46_RS02660 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EPG46_RS02665 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EPG46_RS02680 ENOG4105XIQ Protein of unknown function (DUF2517) EPG46_RS02685 ENOG4105CNA YD repeat protein EPG46_RS02695 ENOG4105CNA YD repeat protein EPG46_RS02700 ENOG41079JQ Membrane EPG46_RS02705 ENOG4105CNA YD repeat protein EPG46_RS02710 ENOG4106R09 EPG46_RS02730 ENOG4107SEY Conserved Protein EPG46_RS02735 ENOG4105CVP deoxyribo-dipyrimidine photolyase EPG46_RS02740 ENOG4105DUX Transporter EPG46_RS02745 ENOG4107QNR UPF0135 protein EPG46_RS02750 ENOG4105P4J Allophanate hydrolase, subunit 1 EPG46_RS02755 ENOG4107R7A Allophanate hydrolase subunit 2 EPG46_RS02760 ENOG4105E7W lamb ycsf family protein EPG46_RS02765 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) EPG46_RS02770 ENOG4108KK1 membrane protein AbrB duplication EPG46_RS02775 ENOG4108MY7 Fimbrial EPG46_RS02780 ENOG4108TTM chaperone EPG46_RS02785 ENOG4106PG1 outer membrane usher protein EPG46_RS02790 ENOG4106UBK fimbrial-like adhesin protein EPG46_RS02795 ENOG4105BZN citrate synthase EPG46_RS02805 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EPG46_RS02810 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EPG46_RS02815 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EPG46_RS02820 ENOG4105E33 succinate dehydrogenase EPG46_RS02825 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EPG46_RS02830 ENOG4105C7S Dehydrogenase EPG46_RS02840 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EPG46_RS02845 ENOG4105FDP GntR family transcriptional regulator EPG46_RS02850 ENOG4105DM4 PTS System EPG46_RS02855 ENOG4105C8I hydrolase, family 38 EPG46_RS02860 ENOG4105C4M (Ubiquinol oxidase) subunit I EPG46_RS02865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EPG46_RS02875 ENOG4105KJB cyd operon protein YbgE EPG46_RS02880 ENOG4107YD3 Thioesterase EPG46_RS02885 ENOG4105E02 MotA TolQ exbB proton channel EPG46_RS02895 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA EPG46_RS02905 ENOG4105KCK Peptidoglycan-associated lipoprotein EPG46_RS02910 ENOG4105UFD tol-pal system protein YbgF EPG46_RS02955 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EPG46_RS02960 ENOG4106Z1T Nicotinamide Mononucleotide Transporter EPG46_RS02965 ENOG4105PGM cation diffusion facilitator family transporter EPG46_RS02970 ENOG4105JND homeobox protein EPG46_RS02975 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EPG46_RS02985 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EPG46_RS02995 ENOG4105F0Z galactose-1-phosphate uridylyltransferase EPG46_RS03000 ENOG4105CMR udp-glucose 4-epimerase EPG46_RS03005 ENOG4105DKW ABC transporter EPG46_RS03010 ENOG4105F4R Transcriptional regulator mode EPG46_RS03020 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EPG46_RS03025 ENOG4105E0C molybdate abc transporter EPG46_RS03030 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS03035 ENOG4108K4B hydrolase EPG46_RS03045 ENOG4105F04 LysR family Transcriptional regulator EPG46_RS03050 ENOG4105C7F AcnD-accessory protein PrpF EPG46_RS03055 ENOG4107QPK )-transporter EPG46_RS03060 ENOG4107QM5 aconitate hydratase EPG46_RS03065 ENOG4105NBR Pectinesterase EPG46_RS03070 ENOG4108V1U phospholipid-binding protein EPG46_RS03075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EPG46_RS03085 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EPG46_RS03090 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EPG46_RS03095 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EPG46_RS03105 ENOG4105CHW UPF0052 protein EPG46_RS03115 ENOG4108RIR Molybdenum cofactor biosynthesis protein EPG46_RS03125 ENOG4105M00 molybdopterin converting factor, subunit 1 EPG46_RS03130 ENOG4108ZAF Molybdopterin EPG46_RS03135 ENOG4105HFZ Membrane EPG46_RS03140 ENOG410733J conserved inner membrane protein EPG46_RS03145 ENOG4107UXM Membrane EPG46_RS03150 ENOG4105DZQ phospholipase D Transphosphatidylase EPG46_RS03155 ENOG4105X23 Endonuclease Exonuclease phosphatase EPG46_RS03160 ENOG4105I9U inner membrane protein ybhQ EPG46_RS03165 ENOG4107QWP ABC-2 type transporter EPG46_RS03170 ENOG4107QWP ABC-2 type transporter EPG46_RS03175 ENOG4105CJ1 ABC, transporter EPG46_RS03185 ENOG4107MVR Transcriptional regulator EPG46_RS03190 ENOG4105C1J atp-dependent rna helicase EPG46_RS03195 ENOG4108UV1 cellular component movement EPG46_RS03200 ENOG4105DVT helicase EPG46_RS03205 ENOG4108MTB glycosyl transferase family EPG46_RS03210 ENOG4105DG4 malate L-lactate dehydrogenase EPG46_RS03215 ENOG4105VR4 UPF0379 protein ybiJ EPG46_RS03220 ENOG4105KSC Transcriptional regulator, TraR DksA family EPG46_RS03230 ENOG4108IU3 tonb-dependent siderophore receptor EPG46_RS03235 ENOG4105ZY9 UPF0379 protein ybiM EPG46_RS03245 ENOG4105D8X mechanosensitive ion channel EPG46_RS03250 ENOG4105CDA abc transporter atp-binding protein EPG46_RS03255 ENOG4105E5Q amino acid AbC transporter EPG46_RS03260 ENOG4107R0W ABC transporter EPG46_RS03270 ENOG4107AQZ Membrane EPG46_RS03280 ENOG4108T1M outer membrane protein x EPG46_RS03285 ENOG4108I6E Sulfatase EPG46_RS03295 ENOG4105KST dependent repressor EPG46_RS03300 ENOG4105F4P )-transporter EPG46_RS03305 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EPG46_RS03310 ENOG4105C5H ABC transporter EPG46_RS03315 ENOG41072TH Protein of unknown function (DUF1479) EPG46_RS03320 ENOG4108HCJ Hydrolase EPG46_RS03330 ENOG4105F1A Pyruvate formate-lyase EPG46_RS03335 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EPG46_RS03340 ENOG4105D06 uba thif-type nad fad binding protein EPG46_RS03345 ENOG4105CVM Molybdenum cofactor synthesis domain protein EPG46_RS03350 ENOG4105D44 asparaginase EPG46_RS03355 ENOG4108JQ6 ABC transporter EPG46_RS03360 ENOG4105DEF Extracellular solute-binding protein, family 5 EPG46_RS03370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EPG46_RS03385 ENOG4105BZU Histidine kinase EPG46_RS03390 ENOG41064RH membrane protein YliF EPG46_RS03400 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway EPG46_RS03405 ENOG4105D8V Glucose sorbosone dehydrogenase EPG46_RS03410 ENOG4108TGY Glutathione S-transferase EPG46_RS03415 ENOG4105DZ1 carboxypeptidase EPG46_RS03420 ENOG4107FB0 transcriptional regulator DeoR family EPG46_RS03425 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EPG46_RS03430 ENOG4107QF7 multi-drug EPG46_RS03440 ENOG4108HCJ Hydrolase EPG46_RS03445 ENOG4106UW1 Major Facilitator superfamily EPG46_RS03450 ENOG4108RFG Tetr family transcriptional regulator EPG46_RS03460 ENOG4105GWF inner membrane protein YbjM EPG46_RS03465 ENOG41090BQ Glutaredoxin EPG46_RS03485 ENOG4108RMJ sensory transduction regulator EPG46_RS03490 ENOG4107RUE extracellular solute-binding protein family 1 EPG46_RS03495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS03500 ENOG4105F38 ABC transporter, permease EPG46_RS03505 ENOG4105D38 putrescine abc transporter EPG46_RS03510 ENOG4105RBQ inner membrane protein ybjO EPG46_RS03515 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) EPG46_RS03520 ENOG4106TNF Periplasmic binding protein EPG46_RS03525 ENOG4105DMR ABC, transporter EPG46_RS03530 ENOG4105GBT ABC transporter EPG46_RS03535 ENOG4106PMH Extracellular solute-binding protein family 3 EPG46_RS03540 ENOG4105E5Z arginine transporter ATP-binding subunit EPG46_RS03545 ENOG41064MM (LipO)protein EPG46_RS03555 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EPG46_RS03560 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase EPG46_RS03565 ENOG4105CGD Nad-dependent epimerase dehydratase EPG46_RS03570 ENOG4105C5W Aldolase EPG46_RS03575 ENOG4105C7K acetolactate synthase EPG46_RS03580 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EPG46_RS03590 ENOG4105DWU Membrane EPG46_RS03595 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EPG46_RS03600 ENOG4105CPB ATP-dependent endonuclease of the OLD family EPG46_RS03605 ENOG4108MJ5 VirK protein EPG46_RS03610 ENOG4105DJY efflux transporter, rnd family, mfp subunit EPG46_RS03615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EPG46_RS03620 ENOG4105VEQ Cold shock protein EPG46_RS03630 ENOG410679B prophage CP4-57 regulatory protein alpA EPG46_RS03670 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EPG46_RS03690 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EPG46_RS03700 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EPG46_RS03710 ENOG4108JJ8 (ABC) transporter EPG46_RS03715 ENOG4108JJ9 ABC, transporter EPG46_RS03720 ENOG4105C3M thioredoxin reductase EPG46_RS03730 ENOG4105CNU cell division protein FtsK EPG46_RS03740 ENOG4105D1H recombination factor protein RarA EPG46_RS03750 ENOG4107QY8 reductase EPG46_RS03755 ENOG4105QAX Iron-sulfur EPG46_RS03760 ENOG4107KGK dmso reductase anchor subunit EPG46_RS03765 ENOG4105CHJ isochorismatase hydrolase EPG46_RS03775 ENOG4105E5D amino acid EPG46_RS03780 ENOG410642W LysR family Transcriptional regulator EPG46_RS03785 ENOG4108X0B nad(p)h dehydrogenase (quinone) EPG46_RS03790 ENOG4105F1A Pyruvate formate-lyase EPG46_RS03795 ENOG4105C6N Formate acetyltransferase EPG46_RS03800 ENOG4105TMB Formate nitrite transporter EPG46_RS03805 ENOG4105DDY UPF0142 protein ycaO EPG46_RS03810 ENOG4107VMU Membrane EPG46_RS03815 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EPG46_RS03825 ENOG4108K0D peptidase, M48 EPG46_RS03835 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EPG46_RS03845 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 EPG46_RS03850 ENOG4105BZ1 (ABC) transporter EPG46_RS03855 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EPG46_RS03860 ENOG4105T0Z Conserved Protein EPG46_RS03875 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups EPG46_RS03880 ENOG4107S90 membrAne EPG46_RS03885 ENOG4106371 Methyltransferase EPG46_RS03895 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) EPG46_RS03900 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) EPG46_RS03905 ENOG4105DIT ErfK YbiS YcfS YnhG family protein EPG46_RS03910 ENOG4105EAQ (twin-arginine translocation) pathway signal EPG46_RS03915 ENOG4105C5X domain protein EPG46_RS03920 ENOG4105CGF Aromatic amino acid aminotransferase EPG46_RS03925 ENOG4105FCK Membrane EPG46_RS03935 ENOG4107RH7 Nicotinate phosphoribosyltransferase EPG46_RS03940 ENOG4105CD8 aminopeptidase N EPG46_RS03945 ENOG4105E2Y ABC, transporter EPG46_RS03950 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EPG46_RS03960 ENOG4105GVF (ABC) transporter EPG46_RS03965 ENOG4108UZX fmn reductase EPG46_RS03970 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon EPG46_RS03975 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae EPG46_RS03980 ENOG4105CW0 outer membrane usher protein EPG46_RS03985 ENOG4108MDY Fimbrial EPG46_RS03990 ENOG4105Q7J Fimbrial EPG46_RS03995 ENOG4105MX3 Fimbrial EPG46_RS04000 ENOG4106PH7 chaperone EPG46_RS04010 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) EPG46_RS04015 ENOG4105QVC MOSC domain-containing protein EPG46_RS04025 ENOG4105C5H ABC transporter EPG46_RS04030 ENOG4105F1S paraquat-inducible protein a EPG46_RS04035 ENOG4105DY2 Paraquat-inducible protein b EPG46_RS04040 ENOG4108Q2G (LipO)protein EPG46_RS04045 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) EPG46_RS04055 ENOG4105DAN ATP-dependent protease EPG46_RS04065 ENOG4105UYK outer membrane protein a EPG46_RS04075 ENOG4108RZ1 DNA transformation protein EPG46_RS04080 ENOG4105EM2 membrane EPG46_RS04085 ENOG410901E Membrane EPG46_RS04090 ENOG41088T4 Helicase IV EPG46_RS04105 ENOG4105K4P CoA-binding domain protein EPG46_RS04120 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 EPG46_RS04125 ENOG4108Z0T Part of a sulfur-relay system (By similarity) EPG46_RS04130 ENOG4108MN8 Membrane EPG46_RS04140 ENOG4105E3S small subunit EPG46_RS04145 ENOG4105DPX Hydrogenase, large subunit EPG46_RS04150 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit EPG46_RS04155 ENOG4108USZ hydrogenase EPG46_RS04160 ENOG4108VXY Hydrogenase-1 operon protein HyaE EPG46_RS04165 ENOG4105MVP hydrogenase-1 operon protein HyaF EPG46_RS04170 ENOG4105C4M (Ubiquinol oxidase) subunit I EPG46_RS04175 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EPG46_RS04185 ENOG4105D6F Phosphatase EPG46_RS04190 ENOG4105D75 Capsular exopolysaccharide family EPG46_RS04195 ENOG4107ZF2 Phosphatase EPG46_RS04200 ENOG4105DAY polysaccharide export protein EPG46_RS04205 ENOG4105E3R (LipO)protein EPG46_RS04210 ENOG4108W78 Pfam:DUF1017 EPG46_RS04215 ENOG4108Y9B (LipO)protein EPG46_RS04225 ENOG41060EU Cold shock-like protein EPG46_RS04230 ENOG4105VEQ Cold shock protein EPG46_RS04245 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation EPG46_RS04250 ENOG4105HEE Binding Domain protein EPG46_RS04255 ENOG4105BZU Histidine kinase EPG46_RS04260 ENOG4108SV3 Tmao reductase system periplasmic protein tort EPG46_RS04265 ENOG4106WF9 DNA-binding transcriptional regulator TorR EPG46_RS04270 ENOG4105CUW cytochrome C-TYPE protein EPG46_RS04275 ENOG4107QY8 reductase EPG46_RS04280 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) EPG46_RS04300 ENOG4105D6F Phosphatase EPG46_RS04305 ENOG4105XH3 EPG46_RS04315 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 EPG46_RS04320 ENOG4105C2W permease EPG46_RS04325 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EPG46_RS04330 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) EPG46_RS04335 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EPG46_RS04345 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) EPG46_RS04350 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) EPG46_RS04355 ENOG4108R86 Transcriptional regulator EPG46_RS04360 ENOG4105C26 Dehydrogenase EPG46_RS04370 ENOG4105CK7 Sodium proline symporter EPG46_RS04380 ENOG410650H (LipO)protein EPG46_RS04385 ENOG4105DBE peroxidase EPG46_RS04390 ENOG4105D5M phosphate starvation-inducible protein EPG46_RS04400 ENOG4105CND Glycosyl transferase, family 2 EPG46_RS04405 ENOG4107BJW polysaccharide deacetylase EPG46_RS04410 ENOG4108TUY outer membrane protein PgaA EPG46_RS04415 ENOG4105BZU Histidine kinase EPG46_RS04430 ENOG4108T85 Membrane EPG46_RS04445 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EPG46_RS04450 ENOG4107SSZ Phosphatase EPG46_RS04455 ENOG4107XHZ cytoplasmic chaperone TorD family protein EPG46_RS04460 ENOG4108UQ5 membrane protein YcdZ EPG46_RS04465 ENOG4105P8Q Curli production assembly transport component CsgG EPG46_RS04470 ENOG4108WYR Curli production assembly transport component, CsgF EPG46_RS04475 ENOG4108XDW curli assembly protein CsgE EPG46_RS04480 ENOG41086KC Transcriptional regulator EPG46_RS04485 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers EPG46_RS04490 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin EPG46_RS04495 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) EPG46_RS04505 ENOG4108UVJ appr-1-p processing domain protein EPG46_RS04510 ENOG4107RZC phospholipase d EPG46_RS04515 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) EPG46_RS04520 ENOG4105DJ9 glucan biosynthesis protein EPG46_RS04525 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) EPG46_RS04530 ENOG4105NAC (LipO)protein EPG46_RS04535 ENOG4108W47 Acidic protein msyB EPG46_RS04545 ENOG4105D1S lipid A biosynthesis EPG46_RS04550 ENOG4105C72 UPF0176 protein EPG46_RS04555 ENOG4108YYC ycei family EPG46_RS04560 ENOG4105DS1 cytochrome b561 EPG46_RS04565 ENOG4106974 biofilm formation EPG46_RS04570 ENOG4105F76 Sarcosine oxidase EPG46_RS04575 ENOG4105PVA Biofilm formation regulatory protein BssS EPG46_RS04580 ENOG4105MEA DNA damage-inducible protein i EPG46_RS04585 ENOG4105EKE dihydroorotase EPG46_RS04590 ENOG4105F3T (LipO)protein EPG46_RS04595 ENOG4105E9S glutaredoxin 2 EPG46_RS04605 ENOG4105D9U N-acetyltransferase EPG46_RS04610 ENOG4108YXG UPF0502 protein EPG46_RS04615 ENOG4105EP9 oxidoreductase EPG46_RS04620 ENOG4105CJR Integral membrane protein (MviN EPG46_RS04625 ENOG4105QVD Flagella synthesis protein FlgN EPG46_RS04630 ENOG4105M9M anti-sigma28 factor FlgM EPG46_RS04635 ENOG4105CKS Flagella basal body P-ring formation protein flgA EPG46_RS04640 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EPG46_RS04645 ENOG4108ZC9 flagellar basal-body rod protein flgc EPG46_RS04650 ENOG4105W00 Flagellar hook capping protein EPG46_RS04655 ENOG4105BZE flagellar hook protein, FlgE EPG46_RS04660 ENOG4108KPB Flagellar basal-body rod protein FlgF EPG46_RS04665 ENOG4105CGA flagellar basal-body rod protein FlgG EPG46_RS04680 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EPG46_RS04685 ENOG4105E1Q flagellar hook-associated protein EPG46_RS04690 ENOG4105DTJ flagellar hook-associated protein EPG46_RS04695 ENOG4107QQB Ribonuclease E EPG46_RS04700 ENOG4105EI2 Pseudouridine synthase EPG46_RS04705 ENOG4108UHJ MAF-like protein EPG46_RS04710 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EPG46_RS04730 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EPG46_RS04735 ENOG4105CHR reductase EPG46_RS04740 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EPG46_RS04745 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EPG46_RS04750 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EPG46_RS04755 ENOG4105HHA aminodeoxychorismate lyase EPG46_RS04765 ENOG4107QRG dna polymerase iii EPG46_RS04770 ENOG4105F8V Hydrolase, tatD family EPG46_RS04775 ENOG4105CI1 PTS System EPG46_RS04780 ENOG4105CNM Receptor EPG46_RS04785 ENOG4105K59 histidine triad (HIT) protein EPG46_RS04790 ENOG41090DQ Lipoprotein EPG46_RS04795 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) EPG46_RS04800 ENOG4108RUM thiamine kinase EPG46_RS04805 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) EPG46_RS04815 ENOG4105CEP NADH dehydrogenase EPG46_RS04820 ENOG4107MBR 17 kDa surface antigen EPG46_RS04825 ENOG4108IND Tetr family transcriptional regulator EPG46_RS04830 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction EPG46_RS04835 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EPG46_RS04840 ENOG4108JA2 transcriptioN-repair coupling factor EPG46_RS04845 ENOG4105IQC Inner membrane protein YcfT EPG46_RS04850 ENOG4105D60 lipoprotein releasing system transmembrane protein EPG46_RS04855 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EPG46_RS04860 ENOG4105D60 lipoprotein releasing system transmembrane protein EPG46_RS04870 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EPG46_RS04885 ENOG4107RUE extracellular solute-binding protein family 1 EPG46_RS04890 ENOG4105D38 putrescine abc transporter EPG46_RS04900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS04905 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EPG46_RS04910 ENOG4105EZE Cupin 4 family protein EPG46_RS04915 ENOG4105IFJ Histidine kinase EPG46_RS04920 ENOG4105XJC Two component transcriptional regulator (Winged helix family EPG46_RS04925 ENOG4107QTF adenylosuccinate lyase EPG46_RS04945 ENOG4108R99 pseudouridine synthase EPG46_RS04950 ENOG4108HMX isocitrate dehydrogenase (NADP) EPG46_RS04955 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) EPG46_RS04975 ENOG41064WM Uncharacterized protein YcgX EPG46_RS04980 ENOG4108XDN Transcriptional regulator EPG46_RS04985 ENOG4105BZU Histidine kinase EPG46_RS04990 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component EPG46_RS04995 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB EPG46_RS05005 ENOG410738I uncharacterized protein ymgC EPG46_RS05010 ENOG4105BZU Histidine kinase EPG46_RS05060 ENOG4107QMS site-determining protein EPG46_RS05065 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EPG46_RS05070 ENOG4105S66 prophage protein EPG46_RS05075 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium EPG46_RS05085 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EPG46_RS05095 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells EPG46_RS05100 ENOG4105KT5 UmuD protein EPG46_RS05105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EPG46_RS05110 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) EPG46_RS05125 ENOG4105ED1 spovr family EPG46_RS05135 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EPG46_RS05145 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EPG46_RS05150 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division EPG46_RS05155 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) EPG46_RS05160 ENOG4105Y3U Transglycosylase-associated protein EPG46_RS05175 ENOG4105VDH Dihydroxyacetone kinase EPG46_RS05180 ENOG4108UTZ Dihydroxyacetone kinase EPG46_RS05185 ENOG4105CMT Dihydroxyacetone kinase EPG46_RS05190 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EPG46_RS05195 ENOG4105I1J Autotransporter EPG46_RS05205 ENOG4105C3G gtp-binding protein EPG46_RS05215 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria EPG46_RS05220 ENOG4105CHH sulfate transporter EPG46_RS05225 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EPG46_RS05230 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EPG46_RS05240 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EPG46_RS05250 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EPG46_RS05255 ENOG4108YY7 Invasion gene expression up-regulator SirB EPG46_RS05260 ENOG41063JG Transcriptional regulator EPG46_RS05285 ENOG4105EWV Sodium calcium exchanger membrane region EPG46_RS05290 ENOG4105WS7 Cation transport regulator EPG46_RS05295 ENOG4108NH8 Cation transport protein EPG46_RS05300 ENOG41090EX DsrE family EPG46_RS05305 ENOG4105ID0 Putative invasin EPG46_RS05310 ENOG4105WH1 Two component transcriptional regulator luxr family EPG46_RS05315 ENOG4105BZU Histidine kinase EPG46_RS05320 ENOG4105DQQ Major facilitator superfamily MFS_1 EPG46_RS05325 ENOG4105CRU nitrate reductase, alpha subunit EPG46_RS05330 ENOG4108IUE nitrate reductase beta subunit EPG46_RS05335 ENOG4105R3A Nitrate reductase EPG46_RS05340 ENOG41076YT nitrate reductase, gamma subunit EPG46_RS05370 ENOG4105CIY formyltetrahydrofolate deformylase EPG46_RS05375 ENOG4105K5B UPF0225 protein EPG46_RS05380 ENOG4105D78 K07001 NTE family protein EPG46_RS05385 ENOG4105I93 response regulator EPG46_RS05390 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EPG46_RS05395 ENOG4108SAU DNA-binding protein H-ns EPG46_RS05400 ENOG4107104 thymidine kinase EPG46_RS05410 ENOG4105C0A alcohol dehydrogenase EPG46_RS05415 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EPG46_RS05420 ENOG4108J59 Extracellular solute-binding protein, family 5 EPG46_RS05425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EPG46_RS05430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EPG46_RS05435 ENOG4105C3U ABC transporter EPG46_RS05440 ENOG4108JQ7 (ABC) transporter EPG46_RS05460 ENOG4107SVH Potassium channel protein EPG46_RS05465 ENOG4105K9H YciI-like protein EPG46_RS05470 ENOG410822N TonB family EPG46_RS05475 ENOG4105NAU thioesterase Superfamily protein EPG46_RS05485 ENOG4108S3I UPF0259 membrane protein EPG46_RS05495 ENOG4105EIF outer membrane protein W EPG46_RS05500 ENOG4108I1J Integrase EPG46_RS05515 ENOG4106G8A Qin prophage EPG46_RS05535 ENOG41087BU transcriptional repressor DicA EPG46_RS05565 ENOG4106JA9 EPG46_RS05570 ENOG4106J3D EPG46_RS05595 ENOG4108MXB Protein of unknown function (DUF968) EPG46_RS05600 ENOG4105KSK (crossover) junction endodeoxyribonuclease EPG46_RS05605 ENOG4105HGD Antitermination protein EPG46_RS05650 ENOG4105QFS Lysis protein S homolog from lambdoid prophage EPG46_RS05665 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 EPG46_RS05685 ENOG4105UZW Tail fiber assembly protein EPG46_RS05710 ENOG4105IM0 capsid protein EPG46_RS05805 ENOG4108WF3 methyltransferase EPG46_RS05825 ENOG4108N8X transition metal ion binding EPG46_RS05830 ENOG4108Z9Z response to DNA damage stimulus EPG46_RS05850 ENOG4105DK0 Indole-3-glycerol phosphate synthase EPG46_RS05855 ENOG4108EFP Anthranilate synthase component II EPG46_RS05860 ENOG4105CRQ synthase (Component I) EPG46_RS05870 ENOG4105DB7 PHP domain protein EPG46_RS05875 ENOG4107RTD sua5 ycio yrdc ywlc family protein EPG46_RS05880 ENOG4105EG3 transmembrane signal peptide protein EPG46_RS05885 ENOG4105FE9 pseudouridine synthase EPG46_RS05890 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EPG46_RS05895 ENOG4105UBK short-chain dehydrogenase reductase EPG46_RS05900 ENOG4105ERU peptidase EPG46_RS05905 ENOG4105RKX Protein of unknown function (DUF2498) EPG46_RS05910 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EPG46_RS05915 ENOG4107R11 Transcriptional regulator EPG46_RS05940 ENOG4107QM5 aconitate hydratase EPG46_RS05950 ENOG4105EYK Phosphatidylglycerophosphatase B EPG46_RS05955 ENOG4105Q4A inner membrane protein yciS EPG46_RS05960 ENOG4105CFV Tetratricopeptide repeat protein EPG46_RS05965 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EPG46_RS05970 ENOG4108ZJT translation initiation factor, Sui1 EPG46_RS05980 ENOG4105N2W Transcriptional regulator EPG46_RS05985 ENOG410643D UPF0509 protein EPG46_RS05990 ENOG4105BZU Histidine kinase EPG46_RS06005 ENOG4105Q4T oxidoreductase EPG46_RS06010 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EPG46_RS06015 ENOG4105WDY DNA (cytosine-5-)-methyltransferase EPG46_RS06020 ENOG4108JQ2 peptide transport system atp-binding protein EPG46_RS06025 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein EPG46_RS06030 ENOG4108EU3 peptide transport system, permease EPG46_RS06035 ENOG4108I5W peptide transport system, permease protein EPG46_RS06040 ENOG4108HIY periplasmic EPG46_RS06045 ENOG4105N0E Protein of unknown function (DUF2543) EPG46_RS06050 ENOG4105CUB amino acid EPG46_RS06060 ENOG4105CFQ glutamine synthetase EPG46_RS06065 ENOG4108Z86 Glutamine amidotransferase EPG46_RS06070 ENOG4107VRI Transcriptional regulator EPG46_RS06075 ENOG4105C26 Dehydrogenase EPG46_RS06080 ENOG4105CJP fad dependent oxidoreductase EPG46_RS06085 ENOG4108JPW Aminotransferase EPG46_RS06090 ENOG4105E51 psp operon transcriptional activator EPG46_RS06095 ENOG41087YS Phage shock protein A EPG46_RS06100 ENOG4105YYT phage shock protein B EPG46_RS06105 ENOG4105FM1 phage shock protein C EPG46_RS06110 ENOG4105NNG Peripheral inner membrane phage-shock protein EPG46_RS06115 ENOG4105K8Z Phage shock protein EPG46_RS06120 ENOG4107QW3 Sucrose phosphorylase EPG46_RS06125 ENOG4105WEM extracellular solute-binding protein EPG46_RS06130 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component EPG46_RS06135 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EPG46_RS06140 ENOG4107RRD Dehydrogenase EPG46_RS06145 ENOG4107TYA transient receptor potential locus EPG46_RS06150 ENOG4105CK5 oxidoreductase EPG46_RS06155 ENOG4105C71 hydrolase family 65, central catalytic EPG46_RS06160 ENOG4107URF beta-phospho-glucomutase EPG46_RS06165 ENOG4108IJ9 (ABC) transporter EPG46_RS06170 ENOG4107EFV Outer membrane protein G EPG46_RS06175 ENOG4105FKQ transcriptional regulator EPG46_RS06180 ENOG4105CM6 amino acid regulated cytosolic protein EPG46_RS06190 ENOG4108JU8 Transcriptional regulator EPG46_RS06195 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EPG46_RS06200 ENOG4107S8C mandelate racemase muconate lactonizing EPG46_RS06205 ENOG4105KXI murein peptide amidase A EPG46_RS06220 ENOG4105ENX hydrolase EPG46_RS06225 ENOG4105EQ2 LysR family Transcriptional regulator EPG46_RS06230 ENOG4107QSI ABC, transporter EPG46_RS06235 ENOG4105D64 Mechanosensitive ion channel EPG46_RS06240 ENOG4105S5I Membrane EPG46_RS06245 ENOG4105Q9Y Universal stress protein EPG46_RS06250 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EPG46_RS06255 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EPG46_RS06260 ENOG4105CFC Transporter EPG46_RS06265 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B EPG46_RS06270 ENOG4105CH2 amidohydrolase EPG46_RS06275 ENOG4106KR7 LysR family Transcriptional regulator EPG46_RS06280 ENOG4108DG9 Smr protein MutS2 EPG46_RS06295 ENOG4105C1J atp-dependent rna helicase EPG46_RS06305 ENOG4108RW8 Universal stress protein F EPG46_RS06310 ENOG4105FCK Membrane EPG46_RS06315 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EPG46_RS06320 ENOG4105IKK cytoplasmic protein EPG46_RS06325 ENOG41090X5 Heat shock protein hslJ EPG46_RS06330 ENOG4105C5I Dehydrogenase EPG46_RS06335 ENOG4107H52 Dicarboxylate transport EPG46_RS06340 ENOG410689M (LipO)protein EPG46_RS06345 ENOG4105WXT Conserved Protein EPG46_RS06350 ENOG4108WFR AraC Family Transcriptional Regulator EPG46_RS06355 ENOG4105C26 Dehydrogenase EPG46_RS06360 ENOG4105F11 amine oxidase EPG46_RS06365 ENOG4105DXM phenylacetic acid degradation protein EPG46_RS06370 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit EPG46_RS06375 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit EPG46_RS06380 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit EPG46_RS06385 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit EPG46_RS06390 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EPG46_RS06395 ENOG4105E39 Enoyl-CoA hydratase EPG46_RS06400 ENOG4108UKI Enoyl-CoA hydratase EPG46_RS06405 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EPG46_RS06410 ENOG4108ZJI phenylacetic acid degradation protein EPG46_RS06415 ENOG4105CHU acetyl-coa acetyltransferase EPG46_RS06420 ENOG4105DZS Phenylacetate-CoA ligase EPG46_RS06425 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein EPG46_RS06430 ENOG4108Z0R Transferase EPG46_RS06450 ENOG4107EF2 surface-exposed virulence protein EPG46_RS06455 ENOG4107S5I aldo keto reductase EPG46_RS06470 ENOG4108HPI phosphatidate Cytidylyltransferase EPG46_RS06475 ENOG4105E8V Alpha Beta Hydrolase Fold protein EPG46_RS06480 ENOG41077RS Phosphatase EPG46_RS06490 ENOG4105CQ7 ATP-dependent helicase EPG46_RS06495 ENOG4107DB1 DUF218 domain EPG46_RS06500 ENOG4105C26 Dehydrogenase EPG46_RS06510 ENOG4105CPW cytochrome b561 EPG46_RS06515 ENOG4105UPP uncharacterized protein ydcA EPG46_RS06520 ENOG4107NK6 Hok/gef family EPG46_RS06525 ENOG4105C8Q Methyl-accepting chemotaxis EPG46_RS06530 ENOG4105DDW LysR family Transcriptional regulator EPG46_RS06535 ENOG4105E32 cytoplasmic protein EPG46_RS06540 ENOG4105DJ9 glucan biosynthesis protein EPG46_RS06545 ENOG4105Z2P Protein of unknown function (DUF465) EPG46_RS06550 ENOG4108Z9I -acetyltransferase EPG46_RS06555 ENOG4107WE3 acetyltransferase YdcK EPG46_RS06560 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein EPG46_RS06565 ENOG41088CC tellurite resistance protein tehB EPG46_RS06570 ENOG4108KKZ (LipO)protein EPG46_RS06580 ENOG4105D7V transposase EPG46_RS06585 ENOG4105DKK Benzoate EPG46_RS06590 ENOG4108JCI Transcriptional regulator EPG46_RS06595 ENOG4105CFP Peptidase U32 EPG46_RS06600 ENOG4105RR0 Protein of unknown function (DUF2554) EPG46_RS06610 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin EPG46_RS06615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EPG46_RS06620 ENOG4107TYH extracellular solute-binding protein family 1 EPG46_RS06625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS06630 ENOG4105D81 ABC transporter, permease EPG46_RS06635 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EPG46_RS06650 ENOG410654E Membrane EPG46_RS06655 ENOG4105R71 cytoplasmic protein EPG46_RS06660 ENOG4108T9Y Inner membrane protein ydcZ EPG46_RS06665 ENOG4108Z7F N-acetyltransferase EPG46_RS06670 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EPG46_RS06675 ENOG4108WYP Transcriptional regulator EPG46_RS06680 ENOG4105CHB tonB-dependent Receptor EPG46_RS06685 ENOG4108NS2 receptor EPG46_RS06690 ENOG4105C85 amino acid EPG46_RS06695 ENOG4108N27 Glutathione S-transferase EPG46_RS06705 ENOG4105CS6 Rhs element vgr protein EPG46_RS06735 ENOG410600T transposase EPG46_RS06740 ENOG4105KZK Tautomerase pptA EPG46_RS06745 ENOG4108MEJ flavin reductase domain protein EPG46_RS06750 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EPG46_RS06755 ENOG4105JAB phenazine biosynthesis protein, phzf family EPG46_RS06760 ENOG4105D0D Nitrate reductase 2, gamma subunit EPG46_RS06765 ENOG4108NZN Respiratory nitrate reductase 2 delta chain EPG46_RS06770 ENOG4108IUE nitrate reductase beta subunit EPG46_RS06775 ENOG4105CRU nitrate reductase, alpha subunit EPG46_RS06780 ENOG4107QND Nitrite extrusion protein EPG46_RS06795 ENOG4105RPH Inner membrane protein YddG EPG46_RS06805 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EPG46_RS06810 ENOG4108MG3 formate dehydrogenase EPG46_RS06815 ENOG41084S7 Plasmid maintenance system antidote protein EPG46_RS06820 ENOG4105DQ4 alcohol dehydrogenase EPG46_RS06825 ENOG4107R1I NAD-dependent malic enzyme EPG46_RS06830 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein EPG46_RS06835 ENOG4105TPS biofilm-dependent modulation protein EPG46_RS06840 ENOG4108Z9K Osmotically inducible protein EPG46_RS06845 ENOG4107H6U ABC transporter EPG46_RS06850 ENOG4105C3U ABC transporter EPG46_RS06855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EPG46_RS06860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EPG46_RS06865 ENOG4105DEF Extracellular solute-binding protein, family 5 EPG46_RS06870 ENOG4108UQS dipeptidase EPG46_RS06875 ENOG4105BZU Histidine kinase EPG46_RS06880 ENOG4105BZU Histidine kinase EPG46_RS06890 ENOG4105F32 YngK protein EPG46_RS06895 ENOG4105E5D amino acid EPG46_RS06905 ENOG4107RAN Peptidase, M16 EPG46_RS06910 ENOG4105PE1 Receptor EPG46_RS06915 ENOG4105CQ0 ABC transporter EPG46_RS06925 ENOG4105C4X radical SAM domain protein EPG46_RS06930 ENOG4105ENH Sulfatase EPG46_RS06935 ENOG4105Z68 AraC Family Transcriptional Regulator EPG46_RS06945 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EPG46_RS06950 ENOG4106PIH fimbrial-like protein ydeQ EPG46_RS06955 ENOG4106318 fimbrial-like protein YdeR EPG46_RS06960 ENOG4108WDE Fimbrial protein EPG46_RS06975 ENOG4105CAF HipA N-terminal domain protein EPG46_RS06980 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein EPG46_RS07000 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) EPG46_RS07005 ENOG4105DKT Transcriptional regulator EPG46_RS07010 ENOG4105C2J ABC transporter EPG46_RS07015 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EPG46_RS07025 ENOG4105D4B ABC, transporter EPG46_RS07030 ENOG41061GT Aldolase EPG46_RS07035 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound EPG46_RS07040 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EPG46_RS07045 ENOG4105FFC UPF0187 protein EPG46_RS07060 ENOG4105M0C cytoplasmic protein EPG46_RS07065 ENOG4105CSV Glutaminase EPG46_RS07070 ENOG4105C26 Dehydrogenase EPG46_RS07075 ENOG4105EGI Transcriptional regulator EPG46_RS07095 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EPG46_RS07100 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF EPG46_RS07105 ENOG4106DNR multiple antibiotic resistance protein EPG46_RS07115 ENOG4105E5W Transporter EPG46_RS07125 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria EPG46_RS07130 ENOG4108YDI single-species biofilm formation on inanimate substrate EPG46_RS07135 ENOG4108WTK competence damage-inducible protein EPG46_RS07140 ENOG4105DGW oligopeptidase A EPG46_RS07145 ENOG4105EMU Dehydrogenase EPG46_RS07150 ENOG4107XBN GntR Family Transcriptional Regulator EPG46_RS07155 ENOG41061EV selenium-binding protein YdfZ EPG46_RS07160 ENOG4105DEI Mannitol dehydrogenase EPG46_RS07170 ENOG4105CPQ Dehydrogenase EPG46_RS07175 ENOG4105CXK mandelate racemase muconate lactonizing EPG46_RS07190 ENOG4108MK9 spermidine N(1)-acetyltransferase EPG46_RS07195 ENOG4105D69 UPF0257 lipoprotein ynfC EPG46_RS07200 ENOG4105KBG Protein of unknown function (DUF1161) EPG46_RS07205 ENOG4107QY8 reductase EPG46_RS07210 ENOG4105C3J Cysteine desulfurase EPG46_RS07215 ENOG4105QAX Iron-sulfur EPG46_RS07220 ENOG4107KGK dmso reductase anchor subunit EPG46_RS07225 ENOG4108NEM leader-binding protein dmsD EPG46_RS07235 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EPG46_RS07240 ENOG4105DAG ROK family EPG46_RS07245 ENOG4106NZI LysR family Transcriptional regulator EPG46_RS07250 ENOG4105D94 Major Facilitator Superfamily EPG46_RS07265 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap EPG46_RS07280 ENOG4105DSF transport protein EPG46_RS07285 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EPG46_RS07290 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EPG46_RS07295 ENOG4105C5D exported protein EPG46_RS07300 ENOG4105D5Q Arginine ornithine antiporter EPG46_RS07310 ENOG4105RA2 Membrane EPG46_RS07315 ENOG4107EXC regulatoR EPG46_RS07320 ENOG4105JJR Histidine kinase EPG46_RS07325 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) EPG46_RS07330 ENOG4105C9Q fumarate hydratase class II EPG46_RS07335 ENOG4107GFK fumarate EPG46_RS07340 ENOG4105EIP mannose-6-phosphate isomerase EPG46_RS07345 ENOG4106J39 exported protein EPG46_RS07350 ENOG4108QNI outer membrane porin protein EPG46_RS07355 ENOG4105CT4 transporter EPG46_RS07360 ENOG4105CNT hydrolase family 2 EPG46_RS07365 ENOG4105XEA Tetr family transcriptional regulator EPG46_RS07370 ENOG4107ZQV short-chain dehydrogenase reductase EPG46_RS07375 ENOG4107P2S Transcriptional regulator EPG46_RS07380 ENOG4105CI1 PTS System EPG46_RS07385 ENOG4105C87 Aminotransferase class I and II EPG46_RS07395 ENOG4105D9R oxidoreductase EPG46_RS07400 ENOG4106C6R beta-lactam resistance protein EPG46_RS07405 ENOG4105QZ5 OriC-binding nucleoid-associated protein EPG46_RS07410 ENOG4105M9B inner membrane protein ydgK EPG46_RS07435 ENOG4108UQQ Electron transport complex EPG46_RS07445 ENOG4105CSM endonuclease III EPG46_RS07450 ENOG4105DUX Transporter EPG46_RS07455 ENOG4108K3A Glutathione S-transferase EPG46_RS07460 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) EPG46_RS07475 ENOG410642K Lysozyme inhibitor EPG46_RS07485 ENOG4108XTF Outer Membrane Lipoprotein EPG46_RS07500 ENOG4105Y49 secretion protein, HlyD family EPG46_RS07505 ENOG4105DSW Fusaric acid resistance protein EPG46_RS07510 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EPG46_RS07515 ENOG4107RGM aldo keto reductase EPG46_RS07520 ENOG4105XZD Fe-S protein EPG46_RS07525 ENOG4108WUH Transcriptional regulator, TetR family EPG46_RS07530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPG46_RS07535 ENOG4108UYE Lactoylglutathione lyase EPG46_RS07540 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EPG46_RS07545 ENOG4107QRT dEAD DEAH box helicase EPG46_RS07550 ENOG4105M2J Glutaredoxin EPG46_RS07555 ENOG4105K4H Nlp p60 protein EPG46_RS07560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EPG46_RS07565 ENOG4105F27 Major Facilitator EPG46_RS07580 ENOG4105F52 Transcriptional regulator EPG46_RS07585 ENOG4105CZQ inner membrane transport protein YdhC EPG46_RS07590 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EPG46_RS07595 ENOG4108R6K riboflavin synthase, subunit alpha EPG46_RS07600 ENOG4107QI1 Mate efflux family protein EPG46_RS07620 ENOG4105N0V mono-oxygenase ydhR EPG46_RS07625 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain EPG46_RS07630 ENOG4108Y7C Conserved Protein EPG46_RS07635 ENOG4108NWD Cytochrome EPG46_RS07640 ENOG4108393 oxidoreductase Fe-S subunit EPG46_RS07645 ENOG4105JVW EPG46_RS07650 ENOG4105WE2 aldehyde ferredoxin oxidoreductase EPG46_RS07655 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein EPG46_RS07660 ENOG4105RFR Protein of unknown function (DUF2767) EPG46_RS07665 ENOG4105CA9 Pyruvate kinase EPG46_RS07670 ENOG4105KMX major outer membrane lipoprotein EPG46_RS07675 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EPG46_RS07690 ENOG4105JRK feS assembly protein SufD EPG46_RS07695 ENOG4105C3K feS assembly ATPase SufC EPG46_RS07700 ENOG4105DIW FeS assembly protein SUFB EPG46_RS07705 ENOG4108Z4V iron-sulfur cluster assembly EPG46_RS07710 ENOG410671Z uncharacterized protein ydiH EPG46_RS07715 ENOG4105KA0 thioesterase Superfamily protein EPG46_RS07720 ENOG4105CQB FAD linked oxidase domain protein EPG46_RS07725 ENOG4105IPI Membrane EPG46_RS07735 ENOG4105SUA Ydil protein EPG46_RS07740 ENOG4105EMV Major Facilitator EPG46_RS07745 ENOG4105EMV Major Facilitator EPG46_RS07760 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) EPG46_RS07765 ENOG4105C1G acyl-Coa dehydrogenase EPG46_RS07770 ENOG4105W4W Transcriptional regulator EPG46_RS07775 ENOG4105CV7 Electron transfer flavoprotein EPG46_RS07780 ENOG4105C10 Electron transfer flavoprotein EPG46_RS07785 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EPG46_RS07790 ENOG41090P5 ferredoxin-like protein EPG46_RS07795 ENOG4105CEY Amp-dependent synthetase and ligase EPG46_RS07800 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EPG46_RS07810 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EPG46_RS07820 ENOG4105CNG UPF0061 protein EPG46_RS07825 ENOG4108TC0 Diguanylate phosphodiesterase EPG46_RS07830 ENOG4108QBX (LipO)protein EPG46_RS07840 ENOG4108V06 Glutathione peroxidase EPG46_RS07855 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EPG46_RS07875 ENOG41082NX 50s ribosomal protein l35 EPG46_RS07880 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EPG46_RS07900 ENOG4108NE3 Salt-induced outer membrane protein EPG46_RS07905 ENOG4105DE4 1-phosphofructokinase EPG46_RS07910 ENOG4105P10 Uncharacterized protein ydiZ EPG46_RS07920 ENOG4107PN8 YfeABCD locus regulator EPG46_RS07925 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 EPG46_RS07930 ENOG4107K5X Membrane-bound metal-dependent hydrolase EPG46_RS07935 ENOG4108ETY sodium dicarboxylate symporter EPG46_RS07950 ENOG4105CH6 catalase EPG46_RS07955 ENOG410901P UPF0249 protein EPG46_RS07960 ENOG4105F8D glycoside hydrolase family 4 EPG46_RS07965 ENOG4105EZV Transcriptional regulator EPG46_RS07970 ENOG4105VCP PTS System EPG46_RS07975 ENOG4105CK1 PTS System EPG46_RS07980 ENOG4105VZJ PTS System EPG46_RS07985 ENOG4105KKI DNA-binding transcriptional activator OsmE EPG46_RS07995 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) EPG46_RS08005 ENOG4108SPG Periplasmic Protein EPG46_RS08015 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) EPG46_RS08020 ENOG4105C26 Dehydrogenase EPG46_RS08035 ENOG4105CGK Exodeoxyribonuclease III EPG46_RS08040 ENOG4108RSN SNARE associated Golgi EPG46_RS08045 ENOG4108KCW iron-sulfur cluster binding EPG46_RS08050 ENOG4108N5C SNARE associated Golgi protein-related protein EPG46_RS08055 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EPG46_RS08060 ENOG4105VNH ABC transporter solute-binding protein EPG46_RS08065 ENOG4105CXZ ABC transporter, permease EPG46_RS08070 ENOG4108VGW abc transporter atp-binding protein EPG46_RS08075 ENOG4107RM6 sulfurtransferase EPG46_RS08080 ENOG4108T9J Cdp-alcohol phosphatidyltransferase EPG46_RS08085 ENOG4105M6F mutator MutT protein EPG46_RS08090 ENOG4105MTM Protein of unknown function (DUF1496) EPG46_RS08095 ENOG4105D82 Glutamate dehydrogenase EPG46_RS08100 ENOG41065FB inner membrane protein ynji EPG46_RS08105 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EPG46_RS08115 ENOG41069NU Nitroreductase EPG46_RS08120 ENOG4105D07 Signal peptide peptidase, SppA EPG46_RS08125 ENOG4105HDK L-asparaginase EPG46_RS08130 ENOG4108RWI nicotinamidase EPG46_RS08135 ENOG4108KUU Inner membrane metabolite transport protein ydjE EPG46_RS08140 ENOG4105E98 transcriptional regulator DeoR family EPG46_RS08145 ENOG4105CPC Aldo Keto reductase EPG46_RS08150 ENOG4107UH8 sugar kinase EPG46_RS08155 ENOG4105D2N Aldolase EPG46_RS08160 ENOG4105CPQ Dehydrogenase EPG46_RS08165 ENOG4107TE1 transport protein EPG46_RS08170 ENOG4105CPQ Dehydrogenase EPG46_RS08175 ENOG4105VUT cytoplasmic protein EPG46_RS08185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EPG46_RS08190 ENOG4105DSB aldose 1-epimerase EPG46_RS08195 ENOG4105CV8 reductase EPG46_RS08200 ENOG4105GNX MltA-interacting MipA family protein EPG46_RS08205 ENOG4105CYN Serine protein kinase EPG46_RS08210 ENOG4106AKX UPF0229 protein EPG46_RS08230 ENOG4108KHP Diguanylate cyclase EPG46_RS08235 ENOG4108KXH Ybak prolyl-tRNA synthetase associated EPG46_RS08250 ENOG4105R1U AraC Family Transcriptional Regulator EPG46_RS08255 ENOG4105DJ2 Major Facilitator Superfamily EPG46_RS08260 ENOG4105K78 MarR family Transcriptional regulator EPG46_RS08265 ENOG4105UCG Domain of unknown function (DUF333) EPG46_RS08270 ENOG410620I Diguanylate cyclase EPG46_RS08275 ENOG4106G4W EPG46_RS08285 ENOG4105Y3U Transglycosylase-associated protein EPG46_RS08290 ENOG4105YP6 Domain of unknown function (DUF1869) EPG46_RS08295 ENOG4108YS1 cytoplasmic protein EPG46_RS08305 ENOG4105EJC lysr family transcriptional regulator EPG46_RS08310 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EPG46_RS08320 ENOG4105DVW rieske (2Fe-2S) EPG46_RS08325 ENOG4105E3J oxidoreductase EPG46_RS08330 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EPG46_RS08335 ENOG4105CEY Amp-dependent synthetase and ligase EPG46_RS08340 ENOG4105Y4Z Outer Membrane Lipoprotein EPG46_RS08345 ENOG41072GX Peptidase M22 Glycoprotease EPG46_RS08350 ENOG4105DVT helicase EPG46_RS08355 ENOG4105M4H endoribonuclease L-psp EPG46_RS08360 ENOG4105V2F Uncharacterized protein yoac EPG46_RS08370 ENOG4105CRQ synthase (Component I) EPG46_RS08375 ENOG4105P8F nudix hydrolase EPG46_RS08380 ENOG4105EJQ L-serine dehydratase EPG46_RS08385 ENOG4107XTP (EAL) domain protein EPG46_RS08390 ENOG4105EE5 Membrane protein terC EPG46_RS08395 ENOG4105DAS pts system EPG46_RS08400 ENOG4105ETZ PTS System EPG46_RS08405 ENOG4105F3R pts system mannose fructose sorbose family iid EPG46_RS08420 ENOG4105DHI Methyltransferase EPG46_RS08435 ENOG4105Q3Y exported protein EPG46_RS08445 ENOG4105TIK EPG46_RS08450 ENOG4105J4Q Transcriptional regulator EPG46_RS08455 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPG46_RS08460 ENOG4105D0M Protease HtpX homolog EPG46_RS08465 ENOG4105CN1 protease EPG46_RS08470 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) EPG46_RS08475 ENOG4108ZGC gaf domain protein EPG46_RS08480 ENOG4105H2K paraquat-inducible protein a EPG46_RS08485 ENOG4105DY2 Paraquat-inducible protein b EPG46_RS08490 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EPG46_RS08495 ENOG4105WT8 Protein of unknown function (DUF1480) EPG46_RS08500 ENOG4105UVW uncharacterized protein yebW EPG46_RS08505 ENOG4108R1E Serine threonine protein phosphatase 1 EPG46_RS08510 ENOG4105NKT exported protein EPG46_RS08515 ENOG4108PNC copper resistance EPG46_RS08520 ENOG4105FXM Copper resistance protein EPG46_RS08525 ENOG4105MPK DNA polymerase III subunit theta EPG46_RS08530 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EPG46_RS08535 ENOG4105UMD exodeoxyribonuclease X EPG46_RS08540 ENOG4105CUG Oligopeptidase b EPG46_RS08545 ENOG4108Q2J Inner membrane protein YebE EPG46_RS08555 ENOG4105X2V dna damage-inducible protein EPG46_RS08560 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR EPG46_RS08565 ENOG4108UHU Aldolase EPG46_RS08570 ENOG4105C01 Dihydroxy-acid dehydratase EPG46_RS08575 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EPG46_RS08580 ENOG4106KNT transcriptional regulator EPG46_RS08585 ENOG4105CA9 Pyruvate kinase EPG46_RS08590 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EPG46_RS08595 ENOG4105DR5 peptidase EPG46_RS08600 ENOG4105NXV High-affinity zinc uptake system protein EPG46_RS08610 ENOG4105FAV ABC, transporter EPG46_RS08630 ENOG4107S01 Repressor protein MetJ EPG46_RS08640 ENOG4105CDY transcriptional regulatory protein EPG46_RS08645 ENOG4108TIT dATP pyrophosphohydrolase EPG46_RS08655 ENOG4105D3W isochorismatase EPG46_RS08660 ENOG41081XQ Conserved Protein EPG46_RS08665 ENOG4105WJG Glutathione EPG46_RS08670 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) EPG46_RS08685 ENOG4105CUW cytochrome C-TYPE protein EPG46_RS08700 ENOG4106ZCM YecM protein EPG46_RS08705 ENOG4105C75 arginyL-tRNA synthetase EPG46_RS08715 ENOG4105W13 flagellar protein EPG46_RS08720 ENOG4105D7B Flagellar biosynthesis protein flha EPG46_RS08725 ENOG4105D00 flagellar biosynthetic protein flhB EPG46_RS08730 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) EPG46_RS08735 ENOG4108VYJ response regulator receiver protein EPG46_RS08745 ENOG4105BZU Histidine kinase EPG46_RS08750 ENOG4105C8Q Methyl-accepting chemotaxis EPG46_RS08755 ENOG4105C8Q Methyl-accepting chemotaxis EPG46_RS08760 ENOG4108V3W Chemotaxis protein, CheW EPG46_RS08765 ENOG4105CBS Chea signal transduction histidine kinase EPG46_RS08770 ENOG4105ER2 Ompa motb domain protein EPG46_RS08775 ENOG4107RD7 Flagellar Motor Protein, MotA EPG46_RS08790 ENOG4108VA4 Universal stress protein EPG46_RS08800 ENOG4108K4C ec 3.1.3.12 EPG46_RS08805 ENOG4105CNN ABC, transporter EPG46_RS08810 ENOG4105C2J ABC transporter EPG46_RS08815 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator EPG46_RS08820 ENOG4108UEC Ferritin-like protein EPG46_RS08825 ENOG4105N4N Protein of unknown function (DUF2766) EPG46_RS08835 ENOG4105P23 (LipO)protein EPG46_RS08840 ENOG41090A1 ferritin EPG46_RS08845 ENOG4105VVZ metal-binding protein EPG46_RS08850 ENOG4105E0U tyrosine-specific transport protein EPG46_RS08855 ENOG4106RHG Yeca family EPG46_RS08880 ENOG4105DZR Type I site-specific deoxyribonuclease EPG46_RS08905 ENOG4105EKQ RNA-directed DNA polymerase EPG46_RS08955 ENOG4105WH1 Two component transcriptional regulator luxr family EPG46_RS08965 ENOG4105XVG cytoplasmic protein EPG46_RS08970 ENOG4105VJY transcriptional regulator EPG46_RS08975 ENOG4105CDA abc transporter atp-binding protein EPG46_RS08980 ENOG4105E5Q amino acid AbC transporter EPG46_RS08985 ENOG4105K6H D-cysteine desulfhydrase EPG46_RS08990 ENOG4105EAB amino acid AbC transporter EPG46_RS08995 ENOG4108M9K flagella biosynthesis protein FliZ EPG46_RS09000 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPG46_RS09010 ENOG4105DTS flagellar hook-associated EPG46_RS09015 ENOG4105MQ3 flagellar protein FliS EPG46_RS09025 ENOG4105E5K Alpha-amylase EPG46_RS09030 ENOG4108W9D (LipO)protein EPG46_RS09035 ENOG41066VF YeeE YedE family protein EPG46_RS09045 ENOG4108RAV Conserved protein EPG46_RS09060 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EPG46_RS09065 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EPG46_RS09070 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EPG46_RS09075 ENOG41090PJ Flagellar assembly protein EPG46_RS09080 ENOG4108JIR Flagellum-specific ATP synthase EPG46_RS09085 ENOG4105GSA Flagellar export protein flij EPG46_RS09090 ENOG4105WF4 Flagellar hook-length control protein EPG46_RS09095 ENOG4107ZI8 flagellar basal body-associated protein flil EPG46_RS09100 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EPG46_RS09105 ENOG4105DD5 Flagellar motor switch protein EPG46_RS09110 ENOG4105K0P flagellar biosynthesis protein EPG46_RS09115 ENOG4105CN7 Flagellar biosynthetic protein FliP EPG46_RS09125 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EPG46_RS09140 ENOG4105YX3 cellular response to acidity EPG46_RS09150 ENOG4105BZU Histidine kinase EPG46_RS09155 ENOG4105VNZ cytoplasmic protein EPG46_RS09160 ENOG4105CKW Inner membrane protein yedI EPG46_RS09165 ENOG4105FDR Membrane EPG46_RS09170 ENOG41090BB DNA mismatch endonuclease (vsr) EPG46_RS09175 ENOG4105DVF Cytosine-specific methyltransferase EPG46_RS09180 ENOG4105EST Metal Dependent Phosphohydrolase EPG46_RS09185 ENOG4105Y0K Inner membrane protein YedR EPG46_RS09190 ENOG4105ZIT Porin Gram-negative type EPG46_RS09200 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) EPG46_RS09205 ENOG4107ZY3 Histidine kinase EPG46_RS09210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EPG46_RS09215 ENOG4105VT2 5-hydroxyisourate hydrolase EPG46_RS09225 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EPG46_RS09230 ENOG4108MEK Metal-binding protein YodA EPG46_RS09260 ENOG4105EYM Major Facilitator superfamily EPG46_RS09265 ENOG4105BZ1 (ABC) transporter EPG46_RS09280 ENOG4105C0W non-ribosomal peptide synthetase EPG46_RS09305 ENOG4107ZSV Receptor EPG46_RS09310 ENOG4105TNG K13735 adhesin invasin EPG46_RS09315 ENOG4105TNG K13735 adhesin invasin EPG46_RS09320 ENOG4105TNG K13735 adhesin invasin EPG46_RS09330 ENOG4105CSH Transporter EPG46_RS09335 ENOG4105FYV Amp nucleosidase EPG46_RS09340 ENOG4105CDY transcriptional regulatory protein EPG46_RS09350 ENOG4105UQX Mate efflux family protein EPG46_RS09360 ENOG4107R11 Transcriptional regulator EPG46_RS09365 ENOG4106P55 Transcriptional regulator EPG46_RS09375 ENOG4108PXI ErfK YbiS YcfS YnhG EPG46_RS09390 ENOG4108YZT Adenosylcobinamide kinase EPG46_RS09405 ENOG4108RVA ribokinase EPG46_RS09425 ENOG41080QX K07048 phosphotriesterase-related protein EPG46_RS09475 ENOG4108P8R EPG46_RS09485 ENOG4105F4K antigen 43 EPG46_RS09490 ENOG4108PZQ Inner membrane protein YeeR EPG46_RS09510 ENOG4105MFG Antirestriction protein EPG46_RS09515 ENOG4108YGG dna repair protein EPG46_RS09525 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles EPG46_RS09560 ENOG4105DR8 Membrane EPG46_RS09575 ENOG4105DZ1 carboxypeptidase EPG46_RS09580 ENOG4105CJB Exodeoxyribonuclease I EPG46_RS09590 ENOG4105CUC YeeE YedE family protein EPG46_RS09595 ENOG4105CUB amino acid EPG46_RS09605 ENOG4105EQ1 Transcriptional regulator EPG46_RS09610 ENOG4107SRH Nad-dependent epimerase dehydratase EPG46_RS09625 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EPG46_RS09630 ENOG4105CIH Imidazole acetol-phosphate transaminase EPG46_RS09635 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EPG46_RS09640 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EPG46_RS09655 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EPG46_RS09665 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) EPG46_RS09670 ENOG4108TJN glycosyl transferase group 1 EPG46_RS09685 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EPG46_RS09690 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EPG46_RS09700 ENOG4105C1B dTDP-glucose 4-6-dehydratase EPG46_RS09705 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EPG46_RS09730 ENOG41090RK glycosyl transferase EPG46_RS09745 ENOG4108KBE Glycosyl transferase, family 2 EPG46_RS09750 ENOG4105D3Q Sugar transferase EPG46_RS09765 ENOG4105DAY polysaccharide export protein EPG46_RS09770 ENOG4108MRJ EPG46_RS09775 ENOG4105MH5 phosphoesterase PA-phosphatase related protein EPG46_RS09780 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EPG46_RS09790 ENOG4105EE5 Membrane protein terC EPG46_RS09795 ENOG4108GAE asmA family EPG46_RS09805 ENOG4105DBI uridine monophosphokinase EPG46_RS09815 ENOG4105D03 DNA-3-methyladenine glycosylase II EPG46_RS09820 ENOG4105R8A Heat shock protein EPG46_RS09830 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase EPG46_RS09835 ENOG4108M24 von Willebrand factor, type A EPG46_RS09865 ENOG4105BZS acriflavin resistance protein EPG46_RS09870 ENOG4105BZS acriflavin resistance protein EPG46_RS09880 ENOG4105EB3 Histidine kinase EPG46_RS09885 ENOG4105E3W Two component transcriptional regulator (Winged helix family EPG46_RS09890 ENOG4105KWI UPF0339 protein EPG46_RS09895 ENOG4105X54 addiction module antidote protein EPG46_RS09905 ENOG4105CFP Peptidase U32 EPG46_RS09910 ENOG41076Z6 Uncharacterized protein yegR EPG46_RS09925 ENOG4107WTH Galactitol-1-phosphate dehydrogenase EPG46_RS09930 ENOG4105DT3 PTS system, galactitol-specific IIc component EPG46_RS09935 ENOG41090UW PTS System EPG46_RS09940 ENOG41082GB PTS system galactitol-specific transporter subunit IIA EPG46_RS09955 ENOG4105EIE fructose-bisphosphate aldolase EPG46_RS09960 ENOG4105EAA nucleoside EPG46_RS09965 ENOG4108KD5 ADP-ribosylation crystallin J1 EPG46_RS09970 ENOG4108TFM Kinase, PfkB family EPG46_RS09975 ENOG4105FDP GntR family transcriptional regulator EPG46_RS09980 ENOG4108UQ1 hydrolase, family 25 EPG46_RS09985 ENOG4105DWF phosphomethylpyrimidine kinase EPG46_RS10005 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly EPG46_RS10010 ENOG410662B Type-1 fimbrial protein EPG46_RS10015 ENOG4105CW0 outer membrane usher protein EPG46_RS10020 ENOG4108MQF Chaperone EPG46_RS10025 ENOG41063W2 Fimbrial protein EPG46_RS10030 ENOG41067AK Protein of unknown function (DUF2574) EPG46_RS10035 ENOG4105D1F ATP-binding protein EPG46_RS10040 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EPG46_RS10055 ENOG4108YCW (LipO)protein EPG46_RS10060 ENOG4108W15 Protein of unknown function (DUF1456) EPG46_RS10065 ENOG4108NEV two component transcriptional regulator, LytTR family EPG46_RS10070 ENOG4108HRK Histidine kinase EPG46_RS10075 ENOG4108XDN Transcriptional regulator EPG46_RS10085 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component EPG46_RS10090 ENOG4108IJ8 ABC transporter EPG46_RS10095 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component EPG46_RS10100 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system EPG46_RS10105 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EPG46_RS10110 ENOG4105CXG d-lactate dehydrogenase EPG46_RS10115 ENOG41061WM D-Alanyl-D-Alanine EPG46_RS10120 ENOG41069YE inner membrane protein yohC EPG46_RS10125 ENOG4105KHU inner membrane protein YohD EPG46_RS10130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EPG46_RS10135 ENOG4105ETP RND efflux system, outer membrane lipoprotein EPG46_RS10145 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EPG46_RS10155 ENOG41067MG lrgb family EPG46_RS10165 ENOG4107GZ4 SanA protein EPG46_RS10170 ENOG4105Y9N Membrane EPG46_RS10175 ENOG4105BZ8 glutamate synthase EPG46_RS10180 ENOG4107SJI Dehydrogenase EPG46_RS10185 ENOG4108HWV )-transporter EPG46_RS10190 ENOG4105C2J ABC transporter EPG46_RS10195 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator EPG46_RS10200 ENOG41060NJ transcriptional regulator EPG46_RS10205 ENOG4105DHF Membrane EPG46_RS10220 ENOG4105D05 Receptor EPG46_RS10225 ENOG4108IQI permease EPG46_RS10230 ENOG4105DUM transcriptional regulator, lysR family EPG46_RS10235 ENOG4105HMI Membrane EPG46_RS10240 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EPG46_RS10245 ENOG4105DD7 kinase (PfkB family EPG46_RS10250 ENOG4105D9N nucleoside EPG46_RS10260 ENOG4108Y4K DNA-binding transcriptional activator EPG46_RS10265 ENOG4105D9N nucleoside EPG46_RS10270 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EPG46_RS10275 ENOG4105DD7 kinase (PfkB family EPG46_RS10280 ENOG4105DM4 PTS System EPG46_RS10285 ENOG4105DE4 1-phosphofructokinase EPG46_RS10290 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EPG46_RS10295 ENOG4105S8Q sugar efflux transporter EPG46_RS10300 ENOG4105KRS Proteinase inhibitor EPG46_RS10310 ENOG4105DEI Mannitol dehydrogenase EPG46_RS10315 ENOG4105CKI cobalamin synthesis protein EPG46_RS10320 ENOG41076MN Phosphoesterase, PA-phosphatase related EPG46_RS10325 ENOG4107TT5 NLP P60 protein EPG46_RS10330 ENOG4105CXC rtn protein EPG46_RS10335 ENOG4105E43 Extracellular solute-binding protein, family 5 EPG46_RS10340 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EPG46_RS10345 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EPG46_RS10350 ENOG4108JQ5 ABC transporter EPG46_RS10355 ENOG4105HG6 EPG46_RS10360 ENOG4105C2C drug resistance transporter, Bcr CflA EPG46_RS10365 ENOG4105I08 Pseudouridine synthase EPG46_RS10370 ENOG4105CFI type iii restriction protein res subunit EPG46_RS10390 ENOG4105E68 Sulfatase EPG46_RS10405 ENOG4105WH1 Two component transcriptional regulator luxr family EPG46_RS10410 ENOG4105KWW Biogenesis protein EPG46_RS10415 ENOG4107QX9 Thiol disulfide interChange protein EPG46_RS10420 ENOG4105DA4 cytochrome c-type biogenesis protein EPG46_RS10430 ENOG4105X3C heme exporter protein EPG46_RS10435 ENOG41060IM Heme exporter protein EPG46_RS10440 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) EPG46_RS10445 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) EPG46_RS10450 ENOG4105CUW cytochrome C-TYPE protein EPG46_RS10455 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) EPG46_RS10460 ENOG4105GXZ Ferredoxin-type protein NapH EPG46_RS10465 ENOG4108BGM Quinol dehydrogenase periplasmic component EPG46_RS10470 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EPG46_RS10475 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase EPG46_RS10480 ENOG4108ZNS ferredoxin-type protein NapF EPG46_RS10495 ENOG4105DWT malate dehydrogenase (quinone) EPG46_RS10500 ENOG4105IBP Cyclic peptide transporter EPG46_RS10505 ENOG4105CF1 Alkylated DNA repair protein EPG46_RS10510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EPG46_RS10515 ENOG4105CJ2 (LipO)protein EPG46_RS10520 ENOG4105FCK Membrane EPG46_RS10525 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC EPG46_RS10530 ENOG41068CG regulatoR EPG46_RS10535 ENOG4105BZU Histidine kinase EPG46_RS10540 ENOG4105BZU Histidine kinase EPG46_RS10545 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EPG46_RS10550 ENOG4107QP7 CoA-transferase subunit A EPG46_RS10555 ENOG4107QNJ CoA-transferase subunit B EPG46_RS10560 ENOG4105CRW Short chain fatty acid transporter EPG46_RS10565 ENOG4105CHU acetyl-coa acetyltransferase EPG46_RS10570 ENOG4105EDV vault protein EPG46_RS10575 ENOG41081SK signal peptide protein EPG46_RS10580 ENOG4107S52 alpha-2-macroglobulin domain protein EPG46_RS10585 ENOG4108QJJ Protein of unknown function (DUF1175) EPG46_RS10590 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) EPG46_RS10595 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPG46_RS10605 ENOG4107GHC outer membrane autotransporter EPG46_RS10610 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EPG46_RS10615 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EPG46_RS10620 ENOG4105XPH Ferredoxin EPG46_RS10625 ENOG4105FQR PH-inducible protein involved in stress response EPG46_RS10650 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EPG46_RS10655 ENOG4105CXY transporter EPG46_RS10660 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A EPG46_RS10665 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B EPG46_RS10670 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EPG46_RS10675 ENOG4105DNE Transposase EPG46_RS10690 ENOG4105CSP Major Facilitator Superfamily EPG46_RS10695 ENOG4105CXK mandelate racemase muconate lactonizing EPG46_RS10705 ENOG4108EWA cinA-like protein EPG46_RS10710 ENOG4108UII YfaZ family EPG46_RS10715 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) EPG46_RS10720 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) EPG46_RS10735 ENOG4105C3I Nad-dependent epimerase dehydratase EPG46_RS10745 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EPG46_RS10755 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) EPG46_RS10760 ENOG4106GZG polymyxin resistance protein B EPG46_RS10765 ENOG4105CEY Amp-dependent synthetase and ligase EPG46_RS10770 ENOG4105DNI Converts SHCHC to OSB (By similarity) EPG46_RS10775 ENOG4108IPT Naphthoate synthase EPG46_RS10780 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EPG46_RS10790 ENOG4105E4F Isochorismate synthase EPG46_RS10795 ENOG4105TNS Conserved Protein EPG46_RS10800 ENOG4107YB6 acetyltransferase, (GNAT) family EPG46_RS10820 ENOG4105GDX Domain of unknown function (DUF1877) EPG46_RS10830 ENOG4105C8S subunit m EPG46_RS10835 ENOG4105D65 subunit l EPG46_RS10845 ENOG4107UFS subunit j EPG46_RS10860 ENOG4107R0R NADH dehydrogenase subunit g EPG46_RS10865 ENOG4107QIZ NADH dehydrogenase EPG46_RS10870 ENOG4105GKE subunit e EPG46_RS10875 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EPG46_RS10890 ENOG4107NQ8 LysR family Transcriptional regulator EPG46_RS10900 ENOG4105CHM Aminotransferase EPG46_RS10910 ENOG4107QWE )-transporter EPG46_RS10915 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 EPG46_RS10920 ENOG4105XWI UPF0304 protein EPG46_RS10930 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EPG46_RS10935 ENOG4105C6K Malic enzyme EPG46_RS10940 ENOG4105CSX c4-dicarboxylate anaerobic carrier EPG46_RS10945 ENOG4105PTV Nudix Hydrolase EPG46_RS10950 ENOG4108RE9 Phosphodiesterase EPG46_RS10955 ENOG4108SHQ Glutathione S-transferase EPG46_RS10960 ENOG4105CYM Glutathione S-transferase EPG46_RS10965 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase EPG46_RS10970 ENOG4105ECP epimerase EPG46_RS10975 ENOG4105DNE Transposase EPG46_RS10980 ENOG4108JEH abc transporter atp-binding protein EPG46_RS10985 ENOG4106YG3 ABC transporter EPG46_RS10990 ENOG4105DSP amino acid AbC transporter EPG46_RS10995 ENOG4105E89 ABC transporter EPG46_RS11000 ENOG4105E89 ABC transporter EPG46_RS11005 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EPG46_RS11010 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EPG46_RS11015 ENOG4105E96 Colicin v production protein EPG46_RS11020 ENOG4108S3P Sporulation domain protein EPG46_RS11025 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EPG46_RS11035 ENOG4105DQR SNARE associated Golgi EPG46_RS11045 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EPG46_RS11050 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) EPG46_RS11055 ENOG4106WZ1 flagella biosynthesis regulator EPG46_RS11060 ENOG4105F9N Major Facilitator Superfamily EPG46_RS11065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EPG46_RS11070 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EPG46_RS11075 ENOG4105MH2 YfcL protein EPG46_RS11080 ENOG4108BPE -transporting atpase EPG46_RS11085 ENOG4105EJ9 Membrane EPG46_RS11090 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) EPG46_RS11100 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EPG46_RS11115 ENOG4105US4 fimbrial-like protein yfcP EPG46_RS11120 ENOG4105UGQ Fimbrial EPG46_RS11125 ENOG4105NEV Fimbrial EPG46_RS11130 ENOG4108FZ9 Chaperone EPG46_RS11145 ENOG4108BY2 phosphohistidine phosphatase EPG46_RS11150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EPG46_RS11155 ENOG4105CHU acetyl-coa acetyltransferase EPG46_RS11160 ENOG4105KZW UPF0381 protein EPG46_RS11165 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation EPG46_RS11175 ENOG410903C (LipO)protein EPG46_RS11180 ENOG4105S64 Formate nitrite transporter EPG46_RS11210 ENOG4108C33 Resolvase EPG46_RS11215 ENOG4105EKQ RNA-directed DNA polymerase EPG46_RS11315 ENOG4105CAR Terminase, large subunit EPG46_RS11380 ENOG4105HRS Antitermination protein EPG46_RS11385 ENOG4108MXB Protein of unknown function (DUF968) EPG46_RS11390 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) EPG46_RS11455 ENOG4105DFP Integrase EPG46_RS11465 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EPG46_RS11470 ENOG4105D7K pfkb domain protein EPG46_RS11475 ENOG4108HKT sucrose-6-phosphate hydrolase EPG46_RS11480 ENOG4106NDP Transcriptional regulator EPG46_RS11490 ENOG4105BZC d-serine deaminase EPG46_RS11495 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPG46_RS11500 ENOG4105CW7 secretion protein, HlyD family EPG46_RS11505 ENOG4108WQH regulatoR EPG46_RS11510 ENOG4105BZU Histidine kinase EPG46_RS11515 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EPG46_RS11520 ENOG4108N2Y auxin Efflux EPG46_RS11525 ENOG4105CFN oxalyl-CoA decarboxylase EPG46_RS11540 ENOG4108V08 YfdX protein EPG46_RS11550 ENOG4105W9M Membrane EPG46_RS11555 ENOG4105D1S lipid A biosynthesis EPG46_RS11565 ENOG4105CHM Aminotransferase EPG46_RS11570 ENOG4108HRK Histidine kinase EPG46_RS11575 ENOG4105DY9 regulatoR EPG46_RS11585 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EPG46_RS11590 ENOG4105CN9 Peptidase m42 family protein EPG46_RS11595 ENOG4105DC7 peptidase M24 EPG46_RS11600 ENOG410863U PTS System EPG46_RS11605 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EPG46_RS11615 ENOG4105VCT ion-transport protein YfeO EPG46_RS11620 ENOG4109076 Conserved Protein EPG46_RS11630 ENOG4105D9N nucleoside EPG46_RS11635 ENOG4108KMM Diguanylate cyclase EPG46_RS11650 ENOG4105HZG regulatoR EPG46_RS11655 ENOG4105GXM Putative transcription regulator (DUF1323) EPG46_RS11690 ENOG4105CN8 Transcriptional regulator EPG46_RS11700 ENOG4105EAA nucleoside EPG46_RS11705 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EPG46_RS11710 ENOG4108NFH Sugar hydrolase EPG46_RS11715 ENOG4108M0I Transcriptional regulator EPG46_RS11720 ENOG4105DHU Bile acid EPG46_RS11725 ENOG4105VRT cytoplasmic protein EPG46_RS11730 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EPG46_RS11745 ENOG4105C6T cysteine synthase EPG46_RS11755 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EPG46_RS11760 ENOG4105C5Y PTS System EPG46_RS11770 ENOG4105M0Y EPG46_RS11775 ENOG4105WEC Molybdate metabolism regulator EPG46_RS11780 ENOG4105C6T cysteine synthase EPG46_RS11785 ENOG4108IJ6 ABC transporter EPG46_RS11790 ENOG4105ECW sulfate abc transporter EPG46_RS11795 ENOG4108I5D sulfate abc transporter EPG46_RS11800 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein EPG46_RS11805 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EPG46_RS11810 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) EPG46_RS11820 ENOG4105C5Y PTS System EPG46_RS11825 ENOG4107S1E Beta-lactamase EPG46_RS11830 ENOG4105EZR dyp-type peroxidase family protein EPG46_RS11835 ENOG4105E7K (LipO)protein EPG46_RS11840 ENOG4105QZU Inner membrane protein YfeZ EPG46_RS11845 ENOG4108R6G acetyltransferase EPG46_RS11850 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase EPG46_RS11860 ENOG4108K3Z AraC family transcriptional regulator EPG46_RS11865 ENOG4108X49 Ethanolamine utilization protein EutK EPG46_RS11870 ENOG4106D67 ethanolamine utilization protein EPG46_RS11880 ENOG4105CPD ethanolamine ammonia-lyase EPG46_RS11885 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase EPG46_RS11890 ENOG4105ENY Ethanolamine utilization protein eutH EPG46_RS11895 ENOG4105C0A alcohol dehydrogenase EPG46_RS11900 ENOG4107RWI ethanolamine utilization protein eutJ EPG46_RS11905 ENOG4108EKI Dehydrogenase EPG46_RS11910 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml EPG46_RS11915 ENOG4105KNY Microcompartments protein EPG46_RS11920 ENOG4107WUY phosphate acetyltransferase EPG46_RS11925 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase EPG46_RS11930 ENOG4105NDK ethanolamine utilization protein EPG46_RS11935 ENOG4106S4J ethanolamine utilization protein EutP EPG46_RS11940 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place EPG46_RS11945 ENOG4105C6K Malic enzyme EPG46_RS11950 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EPG46_RS11955 ENOG4105CV1 Transketolase (EC 2.2.1.1) EPG46_RS11960 ENOG4108PVD exported protein EPG46_RS11970 ENOG4105BZ8 glutamate synthase EPG46_RS11975 ENOG4105BZU Histidine kinase EPG46_RS11980 ENOG4105BZS acriflavin resistance protein EPG46_RS11990 ENOG4105KUZ arsenate reductase EPG46_RS12005 ENOG4106KED esterase YpfH EPG46_RS12010 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) EPG46_RS12015 ENOG4105CGZ zinc metallopeptidase EPG46_RS12025 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EPG46_RS12030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EPG46_RS12035 ENOG4105RH4 Glycine cleavage system transcriptional repressor EPG46_RS12040 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EPG46_RS12045 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) EPG46_RS12050 ENOG4108JPZ Monovalent cation H antiporter subunit D EPG46_RS12055 ENOG4107TDF Formate hydrogenlyase subunit 4 EPG46_RS12060 ENOG4105D65 subunit l EPG46_RS12065 ENOG4107WQX hydrogenase 4 membrane subunit EPG46_RS12070 ENOG4108JPZ Monovalent cation H antiporter subunit D EPG46_RS12075 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EPG46_RS12085 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit EPG46_RS12090 ENOG4105I6X formate hydrogenlyase maturation EPG46_RS12095 ENOG4108JUA Transcriptional regulator EPG46_RS12100 ENOG4105TMB Formate nitrite transporter EPG46_RS12105 ENOG4105C02 permease EPG46_RS12110 ENOG4105ERG peptidase m48, ste24p EPG46_RS12115 ENOG4105K89 arsenate reductase EPG46_RS12120 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) EPG46_RS12125 ENOG4105C2W permease EPG46_RS12135 ENOG4105CXB phosphoribosylaminoimidazole synthetase EPG46_RS12140 ENOG4108V3E phosphoribosylglycinamide formyltransferase EPG46_RS12145 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EPG46_RS12150 ENOG4105C9X ppx gppa phosphatase EPG46_RS12155 ENOG4105BZU Histidine kinase EPG46_RS12165 ENOG41062G3 Protein of unknown function (DUF2633) EPG46_RS12170 ENOG4108ZMA Outer membrane lipoprotein EPG46_RS12175 ENOG41066DY Membrane EPG46_RS12180 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EPG46_RS12185 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EPG46_RS12190 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EPG46_RS12195 ENOG4105VPD cellular component movement EPG46_RS12210 ENOG4105N21 Membrane EPG46_RS12240 ENOG4108JQB penicillin-binding protein 1C EPG46_RS12245 ENOG4105DN3 alpha-2-macroglobulin domain protein EPG46_RS12250 ENOG4105KHC sulfurtransferase EPG46_RS12255 ENOG4105YYA enhanced serine sensitivity protein SseB EPG46_RS12260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EPG46_RS12265 ENOG4105WVQ Fe-S assembly protein IscX EPG46_RS12270 ENOG4108ZIT Ferredoxin, 2FE-2S EPG46_RS12290 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EPG46_RS12310 ENOG4105ECY inositol monophosphatase EPG46_RS12315 ENOG4107XM9 (LipO)protein EPG46_RS12320 ENOG4108MN2 Stationary phase inducible protein CsiE EPG46_RS12325 ENOG4105D8G Major Facilitator superfamily EPG46_RS12330 ENOG4108W5M transcriptional regulator EPG46_RS12335 ENOG4105FUY alpha subunit EPG46_RS12350 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase EPG46_RS12360 ENOG4108SB3 DoxX Family EPG46_RS12365 ENOG4108ZKT aldose 1-epimerase EPG46_RS12370 ENOG4105CPQ Dehydrogenase EPG46_RS12375 ENOG4105CNN ABC, transporter EPG46_RS12380 ENOG4108F37 ATP-binding component of a transport system EPG46_RS12385 ENOG4105FCA ABC transporter periplasmic-binding protein YphF EPG46_RS12390 ENOG4107HQ7 repeat protein EPG46_RS12395 ENOG4108NZE NAGC-like transcriptional regulator EPG46_RS12405 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EPG46_RS12415 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EPG46_RS12420 ENOG4108SKK alpha helix protein EPG46_RS12425 ENOG4107WP9 Histidine kinase EPG46_RS12430 ENOG4107QIK phosphoribosylformylglycinamidine synthase EPG46_RS12440 ENOG4108Z6B deaminase EPG46_RS12445 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB EPG46_RS12450 ENOG4106G6Q Transcriptional regulator EPG46_RS12455 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EPG46_RS12470 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EPG46_RS12490 ENOG4105C3F Signal peptidase i EPG46_RS12500 ENOG4105WMJ Positive regulator of sigma E, RseC MucC EPG46_RS12505 ENOG4105VQK sigma E regulatory protein, MucB RseB EPG46_RS12510 ENOG41069PW sigma-e factor negative regulatory protein EPG46_RS12515 ENOG4105EMN RNA polymerase sigma factor EPG46_RS12525 ENOG4108IYU L-aspartate oxidase EPG46_RS12535 ENOG4105C1J atp-dependent rna helicase EPG46_RS12540 ENOG41090KR LysR family transcriptional Regulator EPG46_RS12560 ENOG4105EIB trna rrna methyltransferase EPG46_RS12565 ENOG4105K63 Thioredoxin EPG46_RS12570 ENOG4106IUH DTW domain containing protein EPG46_RS12575 ENOG4105CD5 CoA-binding domain protein EPG46_RS12580 ENOG4105JIM Phosphatidylserine synthase EPG46_RS12585 ENOG4105T42 (LipO)protein EPG46_RS12590 ENOG4105CSH Transporter EPG46_RS12615 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EPG46_RS12620 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EPG46_RS12625 ENOG4105C34 Pseudouridine synthase EPG46_RS12630 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EPG46_RS12635 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA EPG46_RS12645 ENOG4105CQC Prephenate dehydratase EPG46_RS12650 ENOG4105EHE chorismate mutase- prephenate dehydrogenase EPG46_RS12655 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EPG46_RS12660 ENOG4105QP9 Protein of unknown function (DUF2799) EPG46_RS12665 ENOG4108WS1 EPG46_RS12670 ENOG4108KHX Diguanylate cyclase EPG46_RS12675 ENOG41090EK ompa motb domain protein EPG46_RS12700 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EPG46_RS12705 ENOG4106KVJ cytochrome C assembly protein EPG46_RS12710 ENOG4108JU6 CBS domain protein EPG46_RS12725 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EPG46_RS12730 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EPG46_RS12740 ENOG4108Z1B Cyclase dehydrase EPG46_RS12755 ENOG4108MGN ATP-binding component of a transport system EPG46_RS12780 ENOG4105E54 alpha-amylase EPG46_RS12790 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) EPG46_RS12795 ENOG4105D5U fad dependent oxidoreductase EPG46_RS12800 ENOG4105C26 Dehydrogenase EPG46_RS12805 ENOG4108JPW Aminotransferase EPG46_RS12810 ENOG4105C85 amino acid EPG46_RS12815 ENOG4108PVQ transcriptional regulator EPG46_RS12820 ENOG4109066 lysm domain bon superfamily protein EPG46_RS12825 ENOG4105VPI YqaE family transport protein EPG46_RS12830 ENOG41080HT Transcriptional regulator, arsr family EPG46_RS12835 ENOG4108V62 Rhodanese domain protein EPG46_RS12840 ENOG4108X73 DNA- binding protein EPG46_RS12845 ENOG4108RNS Exports L-alanine (By similarity) EPG46_RS12850 ENOG4108WMJ Protein of unknown function (DUF2002) EPG46_RS12855 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) EPG46_RS12860 ENOG4105WAZ (Glutaredoxin-like protein) NrdH EPG46_RS12870 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EPG46_RS12875 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EPG46_RS12880 ENOG4108IJ7 Glycine betaine EPG46_RS12885 ENOG4108HQS Glycine betaine EPG46_RS12890 ENOG4105GIJ Glycine betaine EPG46_RS12900 ENOG4108UMN azlc family EPG46_RS12905 ENOG4105ZED uncharacterized protein ygaH EPG46_RS12910 ENOG4105NTK Transcriptional repressor Mpra EPG46_RS12915 ENOG4105CW7 secretion protein, HlyD family EPG46_RS12920 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPG46_RS12935 ENOG4105W39 Membrane EPG46_RS12940 ENOG4107VXZ Hydrolase EPG46_RS12970 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EPG46_RS12975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EPG46_RS12990 ENOG4107TH8 cina domain protein EPG46_RS12995 ENOG4105CVE Lytic murein transglycosylase EPG46_RS13000 ENOG410787A Pts system, glucitol sorbitol-specific EPG46_RS13005 ENOG4105DZY Pts system, glucitol sorbitol-specific EPG46_RS13010 ENOG4105VI0 Pts system, glucitol sorbitol-specific EPG46_RS13015 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase EPG46_RS13020 ENOG4105J92 DNA-binding transcriptional activator GutM EPG46_RS13025 ENOG410804X Transcriptional regulator EPG46_RS13030 ENOG4105C2X Arabinose 5-phosphate isomerase EPG46_RS13035 ENOG4108JUA Transcriptional regulator EPG46_RS13040 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center EPG46_RS13045 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase EPG46_RS13050 ENOG4105C8H hydrogenase maturation protein Hypf EPG46_RS13055 ENOG4108RC0 Electron transport protein EPG46_RS13060 ENOG4105DDV Transcriptional regulator (LacI family EPG46_RS13065 ENOG4105C5Y PTS System EPG46_RS13070 ENOG4105CS2 ec 3.2.1.21 EPG46_RS13075 ENOG4108MG9 hydrogenase 3 maturation protease EPG46_RS13080 ENOG4105I6X formate hydrogenlyase maturation EPG46_RS13085 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit EPG46_RS13090 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit EPG46_RS13095 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EPG46_RS13100 ENOG4107TDF Formate hydrogenlyase subunit 4 EPG46_RS13105 ENOG4107R30 NADH dehydrogenase EPG46_RS13110 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) EPG46_RS13115 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA EPG46_RS13120 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) EPG46_RS13125 ENOG4107RSS Hydrogenase accessory protein HypB EPG46_RS13130 ENOG41083WG hydrogenase assembly chaperone EPG46_RS13135 ENOG4105CQS hydrogenase expression formation protein HypD EPG46_RS13140 ENOG4105C45 hydrogenase expression formation protein (HypE) EPG46_RS13145 ENOG4108JUA Transcriptional regulator EPG46_RS13150 ENOG4105VXR cytoplasmic protein EPG46_RS13165 ENOG4105MEW serine threonine protein phosphatase EPG46_RS13170 ENOG4105MVE transcriptional regulator EPG46_RS13175 ENOG4105ZXK Dehydrogenase EPG46_RS13180 ENOG4105G63 Type III effector Hrp-dependent EPG46_RS13185 ENOG4105FB2 class II Aldolase EPG46_RS13190 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EPG46_RS13195 ENOG4105C6Z Gluconate EPG46_RS13200 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPG46_RS13205 ENOG4108K5P (LipO)protein EPG46_RS13240 ENOG4105N0Z inner membrane protein ygbE EPG46_RS13255 ENOG4105C11 sulfate adenylyltransferase), subunit 2 EPG46_RS13260 ENOG4108MXK alkaline phosphatase isozyme conversion EPG46_RS13265 ENOG4105PWE CRISPR-associated protein cas2 EPG46_RS13270 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EPG46_RS13275 ENOG4108Y7V CRISPR-associated protein, Cse3 family EPG46_RS13280 ENOG4108VWQ crispr-associated protein EPG46_RS13285 ENOG41060M0 Crispr-associated protein, cse4 family EPG46_RS13290 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) EPG46_RS13295 ENOG4105CYR Crispr-associated protein, cse1 family EPG46_RS13300 ENOG4105DTT CRISPR-associated helicase, cas3 EPG46_RS13305 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EPG46_RS13310 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EPG46_RS13320 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EPG46_RS13325 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EPG46_RS13330 ENOG4105WQV ferredoxin-like protein EPG46_RS13335 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EPG46_RS13340 ENOG4105YBM electron transfer flavoprotein subunit ygcQ EPG46_RS13345 ENOG4106IKH Electron transfer flavoprotein EPG46_RS13350 ENOG4105C54 Major Facilitator superfamily EPG46_RS13355 ENOG4107R3A FAD linked oxidase domain protein EPG46_RS13360 ENOG4105CHR reductase EPG46_RS13365 ENOG4108ITV Inner membrane protein yqcE EPG46_RS13370 ENOG4108CWB sugar kinase ygcE EPG46_RS13375 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EPG46_RS13385 ENOG4105HA9 of methanol dehydrogenase type EPG46_RS13400 ENOG4105DXN mazG family EPG46_RS13405 ENOG4105MZG transcriptional modulator of maze toxin, mazf EPG46_RS13410 ENOG4106A2Z transcriptional regulator antitoxin, MazE EPG46_RS13415 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EPG46_RS13420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EPG46_RS13425 ENOG4105BZU Histidine kinase EPG46_RS13430 ENOG4105EQX glucarate dehydratase EPG46_RS13435 ENOG4105EQX glucarate dehydratase EPG46_RS13440 ENOG4105DJB Major Facilitator Superfamily EPG46_RS13445 ENOG4105QDK Flavodoxin EPG46_RS13450 ENOG4105DR9 pseudouridine synthase EPG46_RS13455 ENOG4105WP7 tRNA pseudouridine synthase C EPG46_RS13465 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EPG46_RS13470 ENOG4105EWT decarboxylase family EPG46_RS13475 ENOG4105C44 Serine transporter EPG46_RS13480 ENOG4105EJQ L-serine dehydratase EPG46_RS13490 ENOG4105C0A alcohol dehydrogenase EPG46_RS13495 ENOG4107W7X Aldolase EPG46_RS13500 ENOG4105EDR glucose galactose transporter EPG46_RS13505 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) EPG46_RS13510 ENOG4105CMG Carbohydrate kinase EPG46_RS13520 ENOG4107EDW L-fucose operon activator EPG46_RS13530 ENOG4105M08 Membrane EPG46_RS13535 ENOG4105ETT transcriptional Regulator, LysR family EPG46_RS13540 ENOG4105M5B (LipO)protein EPG46_RS13545 ENOG4105C9B Cysteine desulfurase EPG46_RS13550 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EPG46_RS13555 ENOG4105CUZ uba thif-type nad fad binding protein EPG46_RS13560 ENOG4105CA3 membrane-bound lytic murein transglycosylase EPG46_RS13580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EPG46_RS13585 ENOG4108EKC n-acetylglutamate synthase EPG46_RS13590 ENOG4107QYX exodeoxyribonuclease v alpha EPG46_RS13595 ENOG4107QKA exodeoxyribonuclease V beta EPG46_RS13600 ENOG4107QXK peptidase EPG46_RS13605 ENOG4105DSY exodeoxyribonuclease V, gamma EPG46_RS13610 ENOG4105RVB Prepilin peptidase dependent protein c EPG46_RS13615 ENOG4105SEN Protein of unknown function (DUF2509) EPG46_RS13620 ENOG4105JCS prepilin peptidase dependent protein EPG46_RS13625 ENOG4105IPU prepilin peptidase dependent protein A EPG46_RS13640 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EPG46_RS13655 ENOG4105EE5 Membrane protein terC EPG46_RS13660 ENOG4105SUV lipoprotein YgdR EPG46_RS13665 ENOG4105CPC Aldo Keto reductase EPG46_RS13670 ENOG4107S74 Lysophospholipid transporter LplT EPG46_RS13675 ENOG4105CEY Amp-dependent synthetase and ligase EPG46_RS13680 ENOG41060NJ transcriptional regulator EPG46_RS13690 ENOG4105RQF LysR family Transcriptional regulator EPG46_RS13700 ENOG4107QNK )-transporter EPG46_RS13705 ENOG4105CHR reductase EPG46_RS13715 ENOG4105CHU acetyl-coa acetyltransferase EPG46_RS13720 ENOG4108MHD transport protein EPG46_RS13725 ENOG4105ISV protein with bipartite regulator domain EPG46_RS13730 ENOG4108TC1 Transcriptional regulator EPG46_RS13735 ENOG4105FV3 EPG46_RS13760 ENOG4108YAB Invasion protein EPG46_RS13790 ENOG4108RBT type iii secretion EPG46_RS13795 ENOG4106BTR EPG46_RS13805 ENOG4108M6W surface presentation of antigens protein SpaS EPG46_RS13810 ENOG4108TN6 type iii secretion EPG46_RS13815 ENOG4105U07 type iii secretion EPG46_RS13820 ENOG41075IY surface presentation of antigens protein SpaP EPG46_RS13850 ENOG4108K5P (LipO)protein EPG46_RS13855 ENOG4105C7W Xanthine dehydrogenase EPG46_RS13860 ENOG4108HR6 Dehydrogenase EPG46_RS13865 ENOG4108UTP (2Fe-2S)-binding domain protein EPG46_RS13870 ENOG4108JUB Transcriptional regulator EPG46_RS13875 ENOG4105IW6 Carbamoyltransferase EPG46_RS13880 ENOG4107RCH Diaminopropionate ammonia-lyase EPG46_RS13885 ENOG4107S4Y M20 DapE family protein YgeY EPG46_RS13895 ENOG4105C5B carbamate kinase EPG46_RS13900 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family EPG46_RS13905 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC EPG46_RS13910 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase EPG46_RS13915 ENOG4105BZ8 glutamate synthase EPG46_RS13920 ENOG4107UUR Chlorohydrolase aminohydrolase EPG46_RS13925 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase EPG46_RS13930 ENOG4105C7W Xanthine dehydrogenase EPG46_RS13935 ENOG4105C2W permease EPG46_RS13940 ENOG4107QUY Guanine deaminase EPG46_RS13945 ENOG4105C7N Xanthine uracil vitamin C permease EPG46_RS13950 ENOG4108R8B oxidoreductase Fe-S subunit EPG46_RS13955 ENOG4105BZ8 glutamate synthase EPG46_RS13960 ENOG4105C2W permease EPG46_RS13975 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EPG46_RS13980 ENOG4105CRK lysyL-tRNA synthetase EPG46_RS13990 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EPG46_RS13995 ENOG4105T95 Thiol disulfide interChange protein EPG46_RS14000 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EPG46_RS14005 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) EPG46_RS14010 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB EPG46_RS14015 ENOG4105Y75 tpr repeat protein EPG46_RS14025 ENOG4108UT2 hemolysin iii EPG46_RS14030 ENOG4105N5Z UPF0267 protein EPG46_RS14035 ENOG4105CS2 ec 3.2.1.21 EPG46_RS14040 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EPG46_RS14045 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EPG46_RS14065 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EPG46_RS14070 ENOG4105D0A hydroxylase EPG46_RS14075 ENOG4107RAQ aminopeptidase EPG46_RS14095 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EPG46_RS14105 ENOG4108JQ1 Dehydrogenase EPG46_RS14125 ENOG4105D5P Methylmalonyl-coA mutase EPG46_RS14130 ENOG4105DJT lAO AO transport system ATPase EPG46_RS14135 ENOG4108M7F enoyl-CoA hydratase isomerase EPG46_RS14140 ENOG4105CYC Transferase EPG46_RS14145 ENOG4105DEQ transcriptional regulator EPG46_RS14150 ENOG4105MPN Membrane EPG46_RS14155 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EPG46_RS14160 ENOG4105D64 Mechanosensitive ion channel EPG46_RS14165 ENOG4105D2N Aldolase EPG46_RS14180 ENOG4107Z1W Fructose transport system kinase EPG46_RS14185 ENOG4108R4K DNA-binding, transcriptional regulator EPG46_RS14190 ENOG4108Q8A Fructose-1,6-bisphosphatase EPG46_RS14195 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein EPG46_RS14200 ENOG4105CTS PTS system mannitol-specific EPG46_RS14205 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EPG46_RS14210 ENOG4105CV1 Transketolase (EC 2.2.1.1) EPG46_RS14215 ENOG4108K0D peptidase, M48 EPG46_RS14225 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) EPG46_RS14245 ENOG4107QNK )-transporter EPG46_RS14255 ENOG4105RWS endonuclease I EPG46_RS14260 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EPG46_RS14265 ENOG4105D7Z glutathione synthase EPG46_RS14280 ENOG4105CZX twitching motility protein EPG46_RS14285 ENOG4105DFA alanine racemase domain protein EPG46_RS14290 ENOG4108VIA integral membrane protein EPG46_RS14295 ENOG4105VZ9 UPF0235 protein EPG46_RS14300 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EPG46_RS14305 ENOG4105CSA Coproporphyrinogen iii oxidase EPG46_RS14310 ENOG4106MH3 alpha helix chain EPG46_RS14315 ENOG4105HDK L-asparaginase EPG46_RS14320 ENOG4105K33 Periplasmic Protein EPG46_RS14325 ENOG41090ED Protein with unknown function (DUF469) EPG46_RS14335 ENOG4105CEN a g-specific adenine glycosylase EPG46_RS14350 ENOG4105EAA nucleoside EPG46_RS14355 ENOG4105CXN decarboxylase EPG46_RS14360 ENOG4108UQV Membrane EPG46_RS14380 ENOG4108I6E Sulfatase EPG46_RS14385 ENOG4105T40 surface antigen msp4 family protein EPG46_RS14495 ENOG4105TS0 gtp-binding protein EPG46_RS14500 ENOG4108KZE transcriptional regulator EPG46_RS14515 ENOG4106H6R UPF0380 protein EPG46_RS14520 ENOG4106549 Antirestriction protein EPG46_RS14525 ENOG4108YGG dna repair protein EPG46_RS14540 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles EPG46_RS14565 ENOG4105U1E general secretion pathway protein M EPG46_RS14585 ENOG4105X5Z General secretion pathway protein I EPG46_RS14595 ENOG4108VAU general secretion pathway protein G EPG46_RS14600 ENOG4105D7Q type ii secretion system EPG46_RS14615 ENOG4108XKW General secretion pathway protein C EPG46_RS14620 ENOG410765S (LipO)protein EPG46_RS14625 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EPG46_RS14635 ENOG4105F88 accessory colonization factor AcfD EPG46_RS14640 ENOG4105DAA L-lactate EPG46_RS14645 ENOG4107QP3 malate synthase g EPG46_RS14650 ENOG4108ZJF Glcg protein EPG46_RS14655 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EPG46_RS14660 ENOG4105EU8 FAD linked oxidase domain protein EPG46_RS14665 ENOG4105CQB FAD linked oxidase domain protein EPG46_RS14670 ENOG4108KWP DNA-binding transcriptional regulator GlcC EPG46_RS14680 ENOG4107RCI amp-dependent synthetase and ligase EPG46_RS14690 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EPG46_RS14695 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EPG46_RS14705 ENOG4108M8S permease YjgP YjgQ family protein EPG46_RS14710 ENOG4108UUE Transcriptional regulator EPG46_RS14720 ENOG4108S55 polysaccharide biosynthesis protein EPG46_RS14725 ENOG4106FPV ATP-binding protein YghR EPG46_RS14730 ENOG4108NDC ATP-binding protein yghS EPG46_RS14735 ENOG4108GH0 ATP-binding protein yghT EPG46_RS14740 ENOG4105CJ3 phosphate transporter EPG46_RS14745 ENOG4106032 Glutathionylspermidine synthase EPG46_RS14750 ENOG4105CYM Glutathione S-transferase EPG46_RS14755 ENOG41082MF Hydrogenase assembly chaperone hypC hupF EPG46_RS14765 ENOG4108WGS hydrogenase 2-specific chaperone EPG46_RS14770 ENOG4108USZ hydrogenase EPG46_RS14775 ENOG4105DPX Hydrogenase, large subunit EPG46_RS14780 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit EPG46_RS14785 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EPG46_RS14790 ENOG4105E3S small subunit EPG46_RS14795 ENOG410900S Protein of unknown function (DUF2623) EPG46_RS14805 ENOG4105CPC Aldo Keto reductase EPG46_RS14815 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EPG46_RS14820 ENOG4108ZZF transport protein (ExbD) EPG46_RS14825 ENOG4105CWK Biopolymer transport protein, ExbB EPG46_RS14830 ENOG4105C28 cystathionine EPG46_RS14835 ENOG4108K81 inner membrane protein YghB EPG46_RS14840 ENOG4105CF7 AraC family transcriptional regulator EPG46_RS14845 ENOG4108I6A alcohol dehydrogenase EPG46_RS14850 ENOG4105CV8 reductase EPG46_RS14855 ENOG4105ZKC Conserved Protein EPG46_RS14865 ENOG4105CCT upf0313 protein EPG46_RS14870 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) EPG46_RS14875 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase EPG46_RS14880 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPG46_RS14885 ENOG4108J59 Extracellular solute-binding protein, family 5 EPG46_RS14890 ENOG4105WJ3 XRE family Transcriptional regulator EPG46_RS14895 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation EPG46_RS14900 ENOG4105F4I Transcriptional regulator EPG46_RS14905 ENOG4105H4F exported protein EPG46_RS14910 ENOG4105XJC Two component transcriptional regulator (Winged helix family EPG46_RS14915 ENOG4105DHQ Histidine kinase EPG46_RS14920 ENOG4107DEU Inner membrane protein YgiZ EPG46_RS14930 ENOG4105NF4 modulator of drug activity EPG46_RS14935 ENOG4105VRH Antibiotic biosynthesis monooxygenase EPG46_RS14940 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPG46_RS14945 ENOG4105IPS esterase EPG46_RS14950 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EPG46_RS14955 ENOG4108SX3 cytoplasmic protein EPG46_RS14960 ENOG41087AY ADP-Ribose pyrophosphatase EPG46_RS14965 ENOG4105DFG type I secretion outer membrane protein EPG46_RS14975 ENOG4106032 Glutathionylspermidine synthase EPG46_RS14980 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EPG46_RS15000 ENOG4105W0Z cytoplasmic protein EPG46_RS15005 ENOG4105H8W Fimbrial protein EPG46_RS15015 ENOG4108TTM chaperone EPG46_RS15020 ENOG4108MY7 Fimbrial EPG46_RS15030 ENOG4105PV3 Inner membrane protein yqiJ EPG46_RS15035 ENOG4107S78 Band 7 protein EPG46_RS15055 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EPG46_RS15060 ENOG4105I7R Adenylate cyclase EPG46_RS15065 ENOG4106MWK domain protein EPG46_RS15080 ENOG4107ZVW dihydroneopterin aldolase EPG46_RS15105 ENOG4106DSS Tartrate dehydratase subunit alpha EPG46_RS15110 ENOG4107GFK fumarate EPG46_RS15115 ENOG4107QPK )-transporter EPG46_RS15120 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EPG46_RS15130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EPG46_RS15135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPG46_RS15150 ENOG4105Q26 Siderophore-interacting protein EPG46_RS15155 ENOG4105NTW Transcriptional regulator EPG46_RS15160 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EPG46_RS15165 ENOG4105C8Y Acetylornithine aminotransferase EPG46_RS15170 ENOG4108Y51 tRNA-binding protein EPG46_RS15175 ENOG4105CQ4 Transcriptional regulator EPG46_RS15180 ENOG4105CNT hydrolase family 2 EPG46_RS15185 ENOG4105FK9 beta-D-galactosidase beta subunit EPG46_RS15190 ENOG4105E5D amino acid EPG46_RS15195 ENOG4107W6W Conserved Protein EPG46_RS15200 ENOG4107WCA isomerase EPG46_RS15205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EPG46_RS15210 ENOG4108Z3N Transcriptional regulator EPG46_RS15215 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase EPG46_RS15225 ENOG4108VKG metal-dependent hydrolase EPG46_RS15230 ENOG4108UB4 uncharacterized protein ygjQ EPG46_RS15235 ENOG4105EE0 oxidoreductase EPG46_RS15240 ENOG4105DU1 integral membrane protein, terc EPG46_RS15245 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) EPG46_RS15250 ENOG4105P66 Membrane EPG46_RS15255 ENOG4105CTX dehydratase EPG46_RS15265 ENOG4105DPW Major facilitator superfamily MFS_1 EPG46_RS15270 ENOG4107YCY Transcriptional regulator EPG46_RS15275 ENOG4106W5V Membrane EPG46_RS15280 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) EPG46_RS15285 ENOG4105WAY exported protein EPG46_RS15290 ENOG4105NE1 Conserved Protein EPG46_RS15295 ENOG41090KG Inner membrane protein YqjE EPG46_RS15300 ENOG4105YJD EPG46_RS15305 ENOG4108VBZ doxx family EPG46_RS15310 ENOG4105CHF Glutathione S-transferase EPG46_RS15315 ENOG4105KAF membrAne EPG46_RS15320 ENOG4105KAF membrAne EPG46_RS15325 ENOG4105CWB LysR family transcriptional Regulator EPG46_RS15330 ENOG4108CNN domain protein EPG46_RS15335 ENOG4106D80 Uncharacterized protein YhaL EPG46_RS15340 ENOG4105CEM UPF0597 protein EPG46_RS15345 ENOG4105C44 Serine transporter EPG46_RS15350 ENOG4105EJQ L-serine dehydratase EPG46_RS15355 ENOG4105KME endoribonuclease L-psp EPG46_RS15360 ENOG4105C6N Formate acetyltransferase EPG46_RS15365 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EPG46_RS15375 ENOG4105C7B Threonine dehydratase EPG46_RS15380 ENOG410811B TRANSCRIPTIONal EPG46_RS15405 ENOG4105BZW Glycerate kinase EPG46_RS15410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EPG46_RS15420 ENOG4105DJB Major Facilitator Superfamily EPG46_RS15425 ENOG4105CTX dehydratase EPG46_RS15430 ENOG4105ZEG Suppressor protein EPG46_RS15435 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression EPG46_RS15440 ENOG4105E98 transcriptional regulator DeoR family EPG46_RS15445 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of EPG46_RS15450 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB EPG46_RS15460 ENOG4105F3R pts system mannose fructose sorbose family iid EPG46_RS15465 ENOG4108YTN IIa component EPG46_RS15470 ENOG4105CE4 GlcNAc 6-P deacetylase EPG46_RS15475 ENOG4105E70 isomerase EPG46_RS15485 ENOG4108UZY PTS System EPG46_RS15500 ENOG4105F3R pts system mannose fructose sorbose family iid EPG46_RS15505 ENOG4106HBN Galactosamine-6-phosphate isomerase EPG46_RS15510 ENOG4105Q10 Fimbrial-like protein EPG46_RS15515 ENOG4108VCD Chaperone EPG46_RS15520 ENOG4105CW0 outer membrane usher protein EPG46_RS15525 ENOG4105I74 Fimbrial protein EPG46_RS15530 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EPG46_RS15535 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) EPG46_RS15540 ENOG41082RQ UPF0102 protein EPG46_RS15550 ENOG4105W4M Transport-associated protein EPG46_RS15555 ENOG4107S21 permease EPG46_RS15560 ENOG4105K4T epimerase EPG46_RS15565 ENOG4107R7Y intracellular protease Pfpi family EPG46_RS15575 ENOG41082IR Excinuclease ABC C subunit domain protein EPG46_RS15580 ENOG4108YYD acetyltransferase EPG46_RS15600 ENOG4105DEN Luciferase family EPG46_RS15605 ENOG4105CIC tryptophan-specific transport protein EPG46_RS15610 ENOG4105C1J atp-dependent rna helicase EPG46_RS15650 ENOG4105CHV Transcription elongation factor NusA EPG46_RS15670 ENOG4105DIJ Phosphoethanolamine transferase EPG46_RS15680 ENOG4105NTZ Preprotein translocase subunit SecG EPG46_RS15690 ENOG4105EEI dihydropteroate synthase EPG46_RS15695 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EPG46_RS15705 ENOG4105HBR Rna-binding protein EPG46_RS15710 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EPG46_RS15715 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase EPG46_RS15720 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EPG46_RS15725 ENOG4105QYV Membrane EPG46_RS15740 ENOG4105EAH synthase EPG46_RS15745 ENOG4105HVQ Regulatory factor of maltose metabolism EPG46_RS15755 ENOG4105VFK BolA family EPG46_RS15760 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane EPG46_RS15765 ENOG4105E3I toluene tolerance EPG46_RS15770 ENOG4107PE3 Mammalian cell entry related domain protein EPG46_RS15775 ENOG4105CY3 ABC transporter, permease EPG46_RS15780 ENOG4105DHJ ABC, transporter EPG46_RS15785 ENOG4105FEU K -dependent Na -Ca exchanger EPG46_RS15790 ENOG4105C2X Arabinose 5-phosphate isomerase EPG46_RS15795 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EPG46_RS15800 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) EPG46_RS15805 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EPG46_RS15810 ENOG4108IUZ ABC transporter EPG46_RS15815 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPG46_RS15820 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA EPG46_RS15825 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EPG46_RS15835 ENOG41080Z8 PHOSPHOCARRIER protein EPG46_RS15840 ENOG4108NIH transferase activity, transferring phosphorus-containing groups EPG46_RS15850 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain EPG46_RS15855 ENOG4105BZU Histidine kinase EPG46_RS15860 ENOG4105N5T Radical SAM Protein EPG46_RS15865 ENOG4105CBC glutamate synthase EPG46_RS15870 ENOG4105BZ8 glutamate synthase EPG46_RS15875 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon EPG46_RS15880 ENOG4108S1B Periplasmic chaperone protein EPG46_RS15885 ENOG4105E6S usher protein( EPG46_RS15895 ENOG4105UMR response to DNA damage stimulus EPG46_RS15910 ENOG4105DFS Conserved Protein EPG46_RS15915 ENOG4108R66 Conserved Protein EPG46_RS15920 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) EPG46_RS15930 ENOG4105JHE Major Facilitator Superfamily EPG46_RS15940 ENOG4108QBF Transcriptional regulator EPG46_RS15945 ENOG4105CEE C4-dicarboxylate transporter EPG46_RS15950 ENOG4105KB2 stringent starvation protein b EPG46_RS15955 ENOG4107MKT Stringent starvation protein a EPG46_RS15970 ENOG4105D6Z AFG1 family ATPase EPG46_RS15975 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III EPG46_RS15980 ENOG4105C0H protease EPG46_RS15985 ENOG4105C0H protease EPG46_RS16000 ENOG4105RID UPF0379 protein yhcN EPG46_RS16005 ENOG4105UNR (Barnase) inhibitor EPG46_RS16020 ENOG4105ZQC membrane protein AaeX EPG46_RS16025 ENOG4105CR8 Transcriptional regulator EPG46_RS16030 ENOG4105D1U peptidase U62 modulator of DNA gyrase EPG46_RS16035 ENOG4105QD6 exported protein EPG46_RS16040 ENOG4105C03 ribonuclease EPG46_RS16045 ENOG4108Z03 MAF-like protein EPG46_RS16050 ENOG4105VQ7 Rod shape-determining protein MreD EPG46_RS16055 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EPG46_RS16065 ENOG41062P1 Diguanylate cyclase phosphodiesterase EPG46_RS16070 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family EPG46_RS16075 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EPG46_RS16080 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EPG46_RS16085 ENOG4105RG0 Membrane EPG46_RS16090 ENOG4108IA2 Sodium pantothenate symporter EPG46_RS16100 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EPG46_RS16110 ENOG4105CEC DNA methylase N-4 N-6 EPG46_RS16115 ENOG41061ME transport protein EPG46_RS16120 ENOG4108XG4 DNA-binding transcriptional regulator EPG46_RS16125 ENOG4105C1P efflux transporter, rnd family, mfp subunit EPG46_RS16130 ENOG4105BZS acriflavin resistance protein EPG46_RS16135 ENOG4105XCM membrane LIPOPROTEIN EPG46_RS16145 ENOG4105EZ7 amino acid ABC transporter EPG46_RS16150 ENOG4105DRP amino acid AbC transporter EPG46_RS16155 ENOG4105CDA abc transporter atp-binding protein EPG46_RS16195 ENOG4108Z0R Transferase EPG46_RS16200 ENOG4105SG3 Protein of unknown function (DUF1488) EPG46_RS16215 ENOG4108WI1 Dna topoisomerase EPG46_RS16225 ENOG4105C79 DNA protecting protein DprA EPG46_RS16245 ENOG4105C1A potassium transporter peripheral membrane EPG46_RS16255 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system EPG46_RS16260 ENOG4105W1Y Transcriptional regulator EPG46_RS16265 ENOG4105VTS DnaJ-like, subfamily C EPG46_RS16295 ENOG41067V7 50S ribosomal protein L36 EPG46_RS16300 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EPG46_RS16345 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EPG46_RS16390 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EPG46_RS16410 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication EPG46_RS16415 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression EPG46_RS16420 ENOG4107KSE General secretion pathway protein C EPG46_RS16430 ENOG4105GVR general secretion pathway protein D EPG46_RS16435 ENOG4107QHF type ii secretion system protein e EPG46_RS16440 ENOG4105D7Q type ii secretion system EPG46_RS16445 ENOG4108VAU general secretion pathway protein G EPG46_RS16450 ENOG41069X0 general secretion pathway protein h EPG46_RS16465 ENOG4105R04 type II secretion system protein K EPG46_RS16470 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) EPG46_RS16480 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EPG46_RS16485 ENOG4108UQY Iron-storage protein EPG46_RS16490 ENOG4105W53 bacterioferritin-associated ferredoxin EPG46_RS16495 ENOG4108NNZ chitinase EPG46_RS16520 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) EPG46_RS16525 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) EPG46_RS16530 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) EPG46_RS16535 ENOG4105WWK YheO domain protein EPG46_RS16540 ENOG4108V1T peptidylprolyl cis-trans isomerase EPG46_RS16550 ENOG4108YZY peptidylprolyl cis-trans isomerase EPG46_RS16555 ENOG4105VKU nucleicacid-binding protein EPG46_RS16570 ENOG4105C5H ABC transporter EPG46_RS16575 ENOG4105DNZ Alpha Beta Hydrolase EPG46_RS16585 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) EPG46_RS16590 ENOG4108UKZ OsmC family EPG46_RS16600 ENOG410613R integral membrane protein, YccS YhfK family EPG46_RS16605 ENOG4105C8Y Acetylornithine aminotransferase EPG46_RS16610 ENOG4105DDQ anthranilate synthase EPG46_RS16615 ENOG4105MZU cell filamentation protein EPG46_RS16625 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EPG46_RS16635 ENOG4107QZF nitrite reductase NADPH large subunit EPG46_RS16640 ENOG4105WZK nitrite reductase NADPH small subunit EPG46_RS16645 ENOG4107V9H nitrite transporter EPG46_RS16655 ENOG4105VYH EPG46_RS16660 ENOG4107QHQ amino acid EPG46_RS16665 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine EPG46_RS16670 ENOG4107Y0V Not clear, may be involved in an isomerization step EPG46_RS16675 ENOG4108KPW sugar kinase EPG46_RS16680 ENOG4105FDP GntR family transcriptional regulator EPG46_RS16685 ENOG4106PKC pyridoxal phosphate binding EPG46_RS16690 ENOG4106M0N transport system permease protein EPG46_RS16695 ENOG4105MUZ Protein of unknown function DUF2620 EPG46_RS16700 ENOG41080QX K07048 phosphotriesterase-related protein EPG46_RS16705 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EPG46_RS16710 ENOG4108626 Racemase EPG46_RS16715 ENOG4105RMW regulation of transcription, DNA-dependent EPG46_RS16720 ENOG4108M21 EPG46_RS16725 ENOG4105C31 Tryptophanyl-tRNA synthetase EPG46_RS16730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EPG46_RS16735 ENOG4105DJV ribulose-phosphate 3-epimerase EPG46_RS16740 ENOG4105DFE Dna adenine methylase EPG46_RS16745 ENOG4105EGB membrane protein DamX EPG46_RS16750 ENOG4105D49 3-dehydroquinate synthase EPG46_RS16760 ENOG4105E4G Type IV pilus EPG46_RS16765 ENOG4105ITY Required for the use of extracellular DNA as a nutrient EPG46_RS16770 ENOG4105XPX DNA utilization protein HofO EPG46_RS16775 ENOG41065NF Fimbrial assembly family protein EPG46_RS16780 ENOG4108U1Q Pilus assembly protein EPG46_RS16785 ENOG4108JQC penicillin-binding protein 1A EPG46_RS16790 ENOG4107RK2 ADP-ribose diphosphatase NudE EPG46_RS16795 ENOG4105DQY intracellular growth attenuator EPG46_RS16800 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 EPG46_RS16805 ENOG4105VEJ Heat shock protein EPG46_RS16815 ENOG4108MAJ Membrane EPG46_RS16825 ENOG4105E0F Histidine kinase EPG46_RS16835 ENOG4108RRZ Transcription elongation factor GreB EPG46_RS16840 ENOG4105BZM domain protein EPG46_RS16845 ENOG4105XFK Ferrous iron transport protein A EPG46_RS16850 ENOG4105CE1 Ferrous iron transport protein b EPG46_RS16860 ENOG4105DNE Transposase EPG46_RS16865 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EPG46_RS16870 ENOG4105MJ2 Competence protein EPG46_RS16880 ENOG4105C6Z Gluconate EPG46_RS16885 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) EPG46_RS16890 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EPG46_RS16900 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP EPG46_RS16905 ENOG4105E0Y RtcB Protein EPG46_RS16910 ENOG4105CYB regulatoR EPG46_RS16915 ENOG4105E98 transcriptional regulator DeoR family EPG46_RS16930 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EPG46_RS16940 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EPG46_RS16955 ENOG4108IUM Glycogen debranching enzyme EPG46_RS16965 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EPG46_RS16970 ENOG41076UM multiple antibiotic resistance (MarC)-related protein EPG46_RS16975 ENOG4105C6Z Gluconate EPG46_RS16980 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EPG46_RS16985 ENOG4105DIQ Transcriptional regulator EPG46_RS16990 ENOG4105C2I pirin domain protein EPG46_RS16995 ENOG4105D9R oxidoreductase EPG46_RS17000 ENOG4105WCN acetyltransferase EPG46_RS17005 ENOG4105GMB type VI secretion system effector, hcp1 family EPG46_RS17020 ENOG4106FA4 EPG46_RS17025 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EPG46_RS17030 ENOG4105WC8 Conserved Protein EPG46_RS17035 ENOG4107T6V glycerophosphoryl diester phosphodiesterase EPG46_RS17040 ENOG4108IJ9 (ABC) transporter EPG46_RS17045 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EPG46_RS17050 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EPG46_RS17055 ENOG4105BZ7 extracellular solute-binding protein family 1 EPG46_RS17060 ENOG4108IV0 ABC, transporter EPG46_RS17065 ENOG4105C0Z ABC transporter EPG46_RS17070 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EPG46_RS17075 ENOG4105C32 Amino acid ABC transporter (Permease) EPG46_RS17080 ENOG4105CP9 extracellular ligand-binding receptor EPG46_RS17085 ENOG4105U59 -acetyltransferase EPG46_RS17090 ENOG4105CP9 extracellular ligand-binding receptor EPG46_RS17095 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EPG46_RS17100 ENOG4105CRP Part of the ABC transporter FtsEX involved in EPG46_RS17105 ENOG4105CAK Cell division ATP-binding protein ftsE EPG46_RS17110 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EPG46_RS17115 ENOG4106H78 methyltransferase EPG46_RS17120 ENOG4105MG3 Membrane EPG46_RS17130 ENOG4107FS9 Membrane EPG46_RS17135 ENOG4105C59 p-type ATPase EPG46_RS17145 ENOG4105EX9 Membrane EPG46_RS17150 ENOG4108W1V Lipoprotein EPG46_RS17155 ENOG4105F9N Major Facilitator Superfamily EPG46_RS17160 ENOG4105DSF transport protein EPG46_RS17165 ENOG4107YAK holo-(acyl carrier protein) synthase 2 EPG46_RS17170 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EPG46_RS17175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EPG46_RS17180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EPG46_RS17185 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS17190 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS17210 ENOG4105NUP lyase containing HEAT-repeat EPG46_RS17215 ENOG410600T transposase EPG46_RS17220 ENOG4105CMI transporter EPG46_RS17225 ENOG4105CJ1 ABC, transporter EPG46_RS17230 ENOG4105D0S secretion protein (HlyD EPG46_RS17245 ENOG4107UNS conserved inner membrane protein EPG46_RS17250 ENOG4105CBX hi0933 family EPG46_RS17255 ENOG4105CJ3 phosphate transporter EPG46_RS17270 ENOG4105DUX Transporter EPG46_RS17280 ENOG4105DGW oligopeptidase A EPG46_RS17285 ENOG4105D6S protein involved in catabolism of external DNA EPG46_RS17290 ENOG4105DC8 reductase EPG46_RS17300 ENOG4105KBH arsR family transcriptional regulator EPG46_RS17305 ENOG4107R5R arsenical pump membrane protein EPG46_RS17310 ENOG4105K89 arsenate reductase EPG46_RS17320 ENOG4105Y4Z Outer Membrane Lipoprotein EPG46_RS17330 ENOG4105KT7 mgtC SapB transporter EPG46_RS17335 ENOG4105XXV Acid-resistance protein EPG46_RS17340 ENOG41060V2 Acid-resistance protein EPG46_RS17345 ENOG4108YK4 Acid-resistance membrane protein EPG46_RS17350 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci EPG46_RS17360 ENOG4105C1P efflux transporter, rnd family, mfp subunit EPG46_RS17365 ENOG4105BZS acriflavin resistance protein EPG46_RS17375 ENOG4108NKV transcriptional regulator EPG46_RS17385 ENOG4105CA0 peroxidase EPG46_RS17395 ENOG4106S2D Transcriptional regulator EPG46_RS17400 ENOG4105CBN LysR family transcriptional regulator EPG46_RS17405 ENOG4107H3J ribonuclease EPG46_RS17410 ENOG4105CSH Transporter EPG46_RS17415 ENOG41066T0 asmA family EPG46_RS17420 ENOG4105CMB EAL domain-containing protein EPG46_RS17425 ENOG4107SS6 2-dehydro-3-deoxygluconokinase EPG46_RS17430 ENOG4105CS0 peptidase EPG46_RS17440 ENOG4105BZU Histidine kinase EPG46_RS17445 ENOG4105EJG cellulose synthase EPG46_RS17455 ENOG4107EEX Cellulose synthase regulator protein EPG46_RS17460 ENOG4107QZ7 Cellulose synthase catalytic subunit EPG46_RS17470 ENOG410661M cytoplasmic protein EPG46_RS17480 ENOG4105U74 cellulose biosynthesis protein BcsE EPG46_RS17485 ENOG4105WQA Cellulose biosynthesis protein BcsF EPG46_RS17490 ENOG4105D1V cellulose synthase operon protein YhjU EPG46_RS17505 ENOG4105C44 Serine transporter EPG46_RS17510 ENOG4108JQ7 (ABC) transporter EPG46_RS17515 ENOG4105C3U ABC transporter EPG46_RS17520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EPG46_RS17525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EPG46_RS17530 ENOG4105DEF Extracellular solute-binding protein, family 5 EPG46_RS17545 ENOG4105DIJ Phosphoethanolamine transferase EPG46_RS17550 ENOG4105FCD Major Facilitator EPG46_RS17555 ENOG4105EAX Putative lipase EPG46_RS17560 ENOG4108R3E Dna-3-methyladenine glycosylase i EPG46_RS17565 ENOG4105HNP -acetyltransferase EPG46_RS17570 ENOG4107QY8 reductase EPG46_RS17575 ENOG4108ZG0 Ompa motb domain protein EPG46_RS17580 ENOG4105C5I Dehydrogenase EPG46_RS17585 ENOG4106JH6 (LipO)protein EPG46_RS17590 ENOG4105MVF Transcriptional regulator EPG46_RS17600 ENOG41060TC Hok gef cell toxic protein EPG46_RS17620 ENOG4105RGS lipoprotein ysaB EPG46_RS17625 ENOG4105MEV Acyl-transferase EPG46_RS17630 ENOG4108Z12 YiaAB two helix domain-containing protein EPG46_RS17635 ENOG410688U Inner membrane protein yiaB EPG46_RS17640 ENOG4105CMG Carbohydrate kinase EPG46_RS17645 ENOG4105C93 Xylose Isomerase EPG46_RS17650 ENOG4105DFW ABC transporter EPG46_RS17655 ENOG4105C2J ABC transporter EPG46_RS17660 ENOG4108HWW ABC transporter EPG46_RS17665 ENOG4105T16 Transcriptional regulator (AraC family) EPG46_RS17670 ENOG4108UR8 BAX protein EPG46_RS17675 ENOG4107T9C Alpha amylase catalytic region EPG46_RS17680 ENOG4105JKW Valine--pyruvate aminotransferase EPG46_RS17685 ENOG4108XIB electron transport protein ysaA EPG46_RS17690 ENOG4105J4Q Transcriptional regulator EPG46_RS17700 ENOG4108R66 Conserved Protein EPG46_RS17705 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EPG46_RS17710 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EPG46_RS17715 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EPG46_RS17720 ENOG4105CMG Carbohydrate kinase EPG46_RS17725 ENOG4105H6Q decarboxylase EPG46_RS17730 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase EPG46_RS17735 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EPG46_RS17745 ENOG4105GNX MltA-interacting MipA family protein EPG46_RS17750 ENOG4108Q2M Transcriptional regulator EPG46_RS17755 ENOG4105EFX secretion protein, HlyD family EPG46_RS17760 ENOG4105KK7 inner membrane protein YiaW EPG46_RS17770 ENOG4105C26 Dehydrogenase EPG46_RS17775 ENOG4105C0A alcohol dehydrogenase EPG46_RS17780 ENOG4105EM7 Selenocysteine-specific translation elongation factor EPG46_RS17790 ENOG4108U78 Glutathione S-transferase EPG46_RS17805 ENOG4105CNA YD repeat protein EPG46_RS17810 ENOG4105NUP lyase containing HEAT-repeat EPG46_RS17830 ENOG4105EFX secretion protein, HlyD family EPG46_RS17835 ENOG4105FP6 Protein of unknown function (DUF3302) EPG46_RS17840 ENOG4105CTS PTS system mannitol-specific EPG46_RS17850 ENOG4105E61 Mannitol repressor protein EPG46_RS17860 ENOG4108YYI Protein of unknown function (DUF2810) EPG46_RS17865 ENOG4105DAA L-lactate EPG46_RS17870 ENOG41073TP transcriptional regulator EPG46_RS17880 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EPG46_RS17885 ENOG4105D7W serine acetyltransferase EPG46_RS17900 ENOG4105VW4 glutaredoxin 3 EPG46_RS17905 ENOG4107YZP Rhodanese domain protein EPG46_RS17915 ENOG41063SB peptidase EPG46_RS17920 ENOG4105PXI polysaccharide deacetylase EPG46_RS17925 ENOG4105K64 Glycosyl transferase, family 2 EPG46_RS17935 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EPG46_RS17945 ENOG4105XA0 heptosyltransferase ii EPG46_RS17950 ENOG4105D16 lipopolysaccharide heptosyltransferase i EPG46_RS17955 ENOG4108FRV O-antigen ligase EPG46_RS17960 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase EPG46_RS17965 ENOG4108QD8 lipopolysaccharide core biosynthesis protein EPG46_RS17970 ENOG4108PDR lipopolysaccharide core biosynthesis protein EPG46_RS17975 ENOG4105X1N Glycosyl transferase family 8 EPG46_RS17980 ENOG4106AH0 Glycosyl Transferase EPG46_RS17985 ENOG4107XU6 Glycosyl transferase (Group 1 EPG46_RS17990 ENOG4105X1N Glycosyl transferase family 8 EPG46_RS17995 ENOG4107543 (lipo)polysaccharide EPG46_RS18000 ENOG4107RJ7 Glycosyl transferase (Group 1 EPG46_RS18005 ENOG4105DKP glycosyl transferase, family 9 EPG46_RS18010 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EPG46_RS18030 ENOG4105KDC 50s ribosomal protein l28 EPG46_RS18040 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EPG46_RS18045 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EPG46_RS18065 ENOG4105DSJ YicC domain protein EPG46_RS18070 ENOG4105F5P DNA-damage-inducible protein d EPG46_RS18075 ENOG4105EN6 Membrane EPG46_RS18080 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) EPG46_RS18085 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EPG46_RS18095 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EPG46_RS18100 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase EPG46_RS18105 ENOG4105CB5 ATP-dependent DNA helicase recG EPG46_RS18110 ENOG4105D6U Sodium Glutamate Symporter EPG46_RS18115 ENOG4105C2W permease EPG46_RS18120 ENOG4105JV1 AsmA family EPG46_RS18125 ENOG4105CJQ hydrolase, family 31 EPG46_RS18130 ENOG4105CT4 transporter EPG46_RS18145 ENOG4105S8Q sugar efflux transporter EPG46_RS18150 ENOG4108UZ3 Transporter EPG46_RS18155 ENOG4105D01 (LipO)protein EPG46_RS18160 ENOG4105T8A Uncharacterized protein YicS EPG46_RS18170 ENOG4108SAJ Protein of unknown function (DUF1198) EPG46_RS18175 ENOG4105C7N Xanthine uracil vitamin C permease EPG46_RS18180 ENOG4105CPN adenine deaminase EPG46_RS18185 ENOG4105CXY transporter EPG46_RS18190 ENOG4105CXY transporter EPG46_RS18195 ENOG4105BZU Histidine kinase EPG46_RS18200 ENOG4108KX4 response regulator EPG46_RS18205 ENOG4105M71 acetolactate synthase 1 regulatory subunit EPG46_RS18210 ENOG4105C7K acetolactate synthase EPG46_RS18225 ENOG4105E5M Multidrug resistance protein D EPG46_RS18230 ENOG4105J13 transcriptional regulator EPG46_RS18235 ENOG4105JP4 Inner membrane protein yidG EPG46_RS18240 ENOG4105VG5 Membrane EPG46_RS18245 ENOG4106DRA Inner membrane protein YidI EPG46_RS18250 ENOG4105CBG Sulfatase EPG46_RS18255 ENOG4107RUZ Sss sodium solute transporter superfamily EPG46_RS18260 ENOG4108AHD Transcriptional regulator EPG46_RS18270 ENOG4105CI1 PTS System EPG46_RS18275 ENOG4105FDP GntR family transcriptional regulator EPG46_RS18295 ENOG4105R2A (LipO)protein EPG46_RS18300 ENOG4105D99 atp gtp-binding protein EPG46_RS18305 ENOG4107WAP fad NAD(P)-binding domain EPG46_RS18310 ENOG4105DJB Major Facilitator Superfamily EPG46_RS18320 ENOG4108RTU Aldolase EPG46_RS18325 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 EPG46_RS18330 ENOG4105EMF GntR family transcriptional regulator EPG46_RS18335 ENOG410657R replicase EC 2.7 EPG46_RS18340 ENOG410667J hydrolase EPG46_RS18345 ENOG4105VP5 Bacterial protein of unknown function (DUF937) EPG46_RS18350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EPG46_RS18360 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EPG46_RS18375 ENOG4105VG0 50S ribosomal protein l34 EPG46_RS18390 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EPG46_RS18395 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EPG46_RS18410 ENOG4108P6C Tryptophan transporter of low affinity EPG46_RS18415 ENOG4105CNH Multidrug resistance protein MdtL EPG46_RS18420 ENOG4105G2Y Transcriptional regulator EPG46_RS18425 ENOG4105E8Q phosphopantetheinyl transferase EPG46_RS18430 ENOG4108YYH Nadph-dependent fmn reductase EPG46_RS18435 ENOG4105C7N Xanthine uracil vitamin C permease EPG46_RS18440 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 EPG46_RS18445 ENOG4106HGK Inner membrane protein yieI EPG46_RS18460 ENOG4108YXQ IS66 Orf2 family protein EPG46_RS18470 ENOG4106611 bacteriocin immunity EPG46_RS18475 ENOG4107VKM 6-phosphogluconolactonase EPG46_RS18480 ENOG4105DYC esterase EPG46_RS18490 ENOG4105CS2 ec 3.2.1.21 EPG46_RS18495 ENOG4105C5Y PTS System EPG46_RS18500 ENOG4105CID antiterminator EPG46_RS18505 ENOG4108UTW Plays a role in the regulation of phosphate uptake EPG46_RS18510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS18515 ENOG4105E2Z phosphate ABC transporter (Permease EPG46_RS18520 ENOG4105C8U phosphate abc transporter EPG46_RS18525 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) EPG46_RS18530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EPG46_RS18580 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation EPG46_RS18595 ENOG4105QTB Flavodoxin EPG46_RS18600 ENOG4108VVK transcriptional Regulator, AsnC EPG46_RS18610 ENOG4105EV2 VWA domain protein interacting with AAA ATPase EPG46_RS18625 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EPG46_RS18630 ENOG4105C2J ABC transporter EPG46_RS18635 ENOG4105CNN ABC, transporter EPG46_RS18640 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EPG46_RS18645 ENOG4108RVA ribokinase EPG46_RS18650 ENOG4105ETE Transcriptional regulator (LacI family EPG46_RS18655 ENOG4105C0R drug resistance transporter emrb qaca subfamily EPG46_RS18660 ENOG4107EJG GntR family transcriptional regulator EPG46_RS18700 ENOG4108WFC UPF0438 protein yifE EPG46_RS18705 ENOG4105C0P Mg chelatase subunit ChlI EPG46_RS18725 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit EPG46_RS18730 ENOG4105CM2 brancheD-chain amino acid aminotransferase EPG46_RS18740 ENOG4105C7B Threonine dehydratase EPG46_RS18745 ENOG4105EMY transcriptional regulator EPG46_RS18755 ENOG4105KQ5 peptidylprolyl cis-trans isomerase EPG46_RS18765 ENOG4105C4R Atp-dependent dna helicase EPG46_RS18790 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EPG46_RS18795 ENOG4105ESV Glycosyl transferase, family 4 EPG46_RS18800 ENOG4105SFE lipopolysaccharide biosynthesis protein EPG46_RS18805 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EPG46_RS18810 ENOG4107QQG Dehydrogenase EPG46_RS18815 ENOG4105C1B dTDP-glucose 4-6-dehydratase EPG46_RS18820 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EPG46_RS18825 ENOG4108WJ1 acetyltransferase EPG46_RS18830 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EPG46_RS18835 ENOG4105EGZ biosynthesis protein EPG46_RS18840 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) EPG46_RS18845 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) EPG46_RS18850 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EPG46_RS18855 ENOG4105C85 amino acid EPG46_RS18880 ENOG4105C4X radical SAM domain protein EPG46_RS18885 ENOG4105ENH Sulfatase EPG46_RS18890 ENOG410601J HemY protein EPG46_RS18895 ENOG4105ECF c-methyltransferase EPG46_RS18900 ENOG41076E6 Uroporphyrinogen-III Synthase EPG46_RS18905 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EPG46_RS18910 ENOG4107T0K Adenylate cyclase EPG46_RS18920 ENOG4105S7Z (LipO)protein EPG46_RS18930 ENOG4105CT0 Protein of unknown function, DUF484 EPG46_RS18940 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant EPG46_RS18945 ENOG4105C4R Atp-dependent dna helicase EPG46_RS18950 ENOG4108T58 Mg2 transport protein CorA EPG46_RS18955 ENOG4107QUT magnesium and cobalt transport protein CorA EPG46_RS18960 ENOG4105NRM Membrane EPG46_RS18965 ENOG4106WR8 Inner membrane protein YigG EPG46_RS18970 ENOG4105FR1 rard protein EPG46_RS18975 ENOG4108VUY thioesterase Superfamily protein EPG46_RS18980 ENOG4105HDD phospholipase EPG46_RS18985 ENOG4105C9U ATP-dependent DNA helicase RecQ EPG46_RS18990 ENOG4105CCF Lysine exporter protein (Lyse ygga) EPG46_RS18995 ENOG410829K Lysine exporter protein (Lyse ygga) EPG46_RS19000 ENOG4108EUD Lysophospholipase EPG46_RS19005 ENOG4105DQF Hydrolase EPG46_RS19010 ENOG4105EMK carboxylate amino acid amine transporter EPG46_RS19015 ENOG4105DZ2 Transcriptional regulator EPG46_RS19020 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EPG46_RS19025 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) EPG46_RS19030 ENOG4108I5U Uridine phosphorylase EPG46_RS19035 ENOG4105CGY Dna recombination protein EPG46_RS19045 ENOG4105JC1 sterol-binding domain protein EPG46_RS19055 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EPG46_RS19060 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EPG46_RS19065 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EPG46_RS19070 ENOG4105F8V Hydrolase, tatD family EPG46_RS19075 ENOG4105MDZ Transcriptional activator rfaH EPG46_RS19080 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EPG46_RS19085 ENOG4108EX3 reductase EPG46_RS19090 ENOG4105CHU acetyl-coa acetyltransferase EPG46_RS19095 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EPG46_RS19105 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EPG46_RS19110 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EPG46_RS19115 ENOG4108RR8 protoporphyrinogen oxidase EPG46_RS19145 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b EPG46_RS19150 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EPG46_RS19155 ENOG4105PC1 Conserved Protein EPG46_RS19160 ENOG4105E27 serine threonine protein kinase EPG46_RS19165 ENOG4108Z33 Thiol disulfide Interchange Protein EPG46_RS19175 ENOG4106HNH Acyl-transferase EPG46_RS19180 ENOG4105C2M dna polymerase I EPG46_RS19195 ENOG4105D4P Coproporphyrinogen iii oxidase EPG46_RS19200 ENOG4106FIY EPG46_RS19205 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EPG46_RS19210 ENOG4105CUX Signal transduction histidine kinase EPG46_RS19215 ENOG4105C5F glutamine synthetase EPG46_RS19220 ENOG4105CI3 gtp-binding protein typa EPG46_RS19225 ENOG4108K85 Transcriptional regulator EPG46_RS19230 ENOG4108KHF Resistance protein EPG46_RS19235 ENOG4105R9B Major Facilitator EPG46_RS19240 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is EPG46_RS19245 ENOG4105CT4 transporter EPG46_RS19250 ENOG4105CT4 transporter EPG46_RS19255 ENOG4105CJQ hydrolase, family 31 EPG46_RS19260 ENOG4107WI4 Aldose-1-epimerase EPG46_RS19265 ENOG4107QKS N-acylglucosamine 2-epimerase EPG46_RS19270 ENOG4105D2M Aldolase EPG46_RS19275 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EPG46_RS19280 ENOG4108MGF sugar kinase EPG46_RS19285 ENOG4105E98 transcriptional regulator DeoR family EPG46_RS19290 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 EPG46_RS19305 ENOG4105SUU thioesterase domain EPG46_RS19315 ENOG41068KX affects formate dehydrogenase-N EPG46_RS19320 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) EPG46_RS19325 ENOG4108MG3 formate dehydrogenase EPG46_RS19330 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EPG46_RS19340 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EPG46_RS19345 ENOG4108V87 frv operon regulatory protein EPG46_RS19350 ENOG4106C3V frv operon regulatory protein EPG46_RS19355 ENOG4105CN9 Peptidase m42 family protein EPG46_RS19360 ENOG4105DM4 PTS System EPG46_RS19365 ENOG41064BA PTS system, fructose-specific, IIA component EPG46_RS19380 ENOG4105DKG l-rhamnose isomerase EPG46_RS19385 ENOG4105DET Rhamnulokinase EPG46_RS19400 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) EPG46_RS19405 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EPG46_RS19415 ENOG4108RPX mosc domain containing protein EPG46_RS19420 ENOG4105E0F Histidine kinase EPG46_RS19425 ENOG4105E3W Two component transcriptional regulator (Winged helix family EPG46_RS19430 ENOG4105FMW periplasmic EPG46_RS19445 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EPG46_RS19450 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) EPG46_RS19460 ENOG4105EBK exported protein EPG46_RS19465 ENOG4108VTS Membrane EPG46_RS19470 ENOG41065TG regulatoR EPG46_RS19480 ENOG4105DP0 ferredoxin-NADP reductase EPG46_RS19485 ENOG4105CBT Fructose-1,6-bisphosphatase EPG46_RS19495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EPG46_RS19510 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EPG46_RS19525 ENOG41063M6 Cell Division Protein EPG46_RS19530 ENOG4105ETE Transcriptional regulator (LacI family EPG46_RS19535 ENOG4105C25 Primosomal protein n' EPG46_RS19545 ENOG4107S01 Repressor protein MetJ EPG46_RS19555 ENOG4105C28 cystathionine EPG46_RS19560 ENOG4105CFH Aspartokinase EPG46_RS19565 ENOG4105SYT Methylenetetrahydrofolate reductase EPG46_RS19575 ENOG4108Q5Y Membrane EPG46_RS19580 ENOG4108XC3 NADH ubiquinone oxidoreductase EPG46_RS19585 ENOG4105DCT glycerol dehydrogenase EPG46_RS19590 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EPG46_RS19595 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EPG46_RS19600 ENOG4105DM4 PTS System EPG46_RS19605 ENOG4108YRF PTS System EPG46_RS19615 ENOG4108AHH pyruvate formate lyase II activase EPG46_RS19620 ENOG4108XCZ PTS System EPG46_RS19625 ENOG4106R3P AraC family transcriptional regulator EPG46_RS19630 ENOG4105DIJ Phosphoethanolamine transferase EPG46_RS19635 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EPG46_RS19640 ENOG4105CWC Acetylornithine deacetylase EPG46_RS19645 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EPG46_RS19660 ENOG4105C5Q Transcriptional regulator EPG46_RS19670 ENOG4105EJ2 Transcriptional regulator EPG46_RS19675 ENOG4108Y73 Membrane EPG46_RS19685 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) EPG46_RS19690 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EPG46_RS19715 ENOG4105D4A Cell wall formation (By similarity) EPG46_RS19720 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EPG46_RS19755 ENOG4105PM1 preprotein translocase subunit SecE EPG46_RS19760 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EPG46_RS19795 ENOG410645W Thiamin biosynthesis protein ThiH EPG46_RS19800 ENOG4105D41 biosynthesis protein thiH EPG46_RS19805 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EPG46_RS19810 ENOG4105WHD thiamine biosynthesis protein ThiS EPG46_RS19815 ENOG4105D06 uba thif-type nad fad binding protein EPG46_RS19850 ENOG4105R2J Conserved Protein EPG46_RS19860 ENOG4108T8B Protein of unknown function (DUF1481) EPG46_RS19865 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism EPG46_RS19870 ENOG4105BZU Histidine kinase EPG46_RS19875 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EPG46_RS19880 ENOG4105C12 Phosphoribosylglycinamide synthetase EPG46_RS19885 ENOG4105DC1 bifunctional purine biosynthesis protein purh EPG46_RS19910 ENOG41062WK cellular response to acidity EPG46_RS19915 ENOG4105K5X acetyltransferase EPG46_RS19920 ENOG4105CVG Homoserine O-transsuccinylase EPG46_RS19925 ENOG4107QP3 malate synthase g EPG46_RS19930 ENOG4108I9X Isocitrate lyase EPG46_RS19935 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) EPG46_RS19945 ENOG41069M3 Transcriptional regulator EPG46_RS19950 ENOG4105C3R Methionine synthase EPG46_RS19955 ENOG4105EAM Na Pi-cotransporter EPG46_RS19965 ENOG4105FE9 pseudouridine synthase EPG46_RS19970 ENOG4108ZR5 Conserved Protein EPG46_RS19975 ENOG4105CFH Aspartokinase EPG46_RS19980 ENOG4107QP8 phosphohexose isomerase EPG46_RS19990 ENOG4108MDC (LipO)protein EPG46_RS19995 ENOG4108Q9C Periplasmic Protein EPG46_RS20000 ENOG4105E3R (LipO)protein EPG46_RS20020 ENOG4107QNK )-transporter EPG46_RS20025 ENOG4105EG2 ABC transporter, permease EPG46_RS20030 ENOG4105D56 permease protein EPG46_RS20035 ENOG4107FKK extracellular solute-binding protein family 1 EPG46_RS20040 ENOG4108IJ9 (ABC) transporter EPG46_RS20045 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) EPG46_RS20050 ENOG4107W52 maltose operon periplasmic protein EPG46_RS20060 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) EPG46_RS20075 ENOG41080IJ Diacylglycerol kinase EPG46_RS20085 ENOG4107R73 Mate efflux family protein EPG46_RS20090 ENOG4105VDW Csbd family EPG46_RS20095 ENOG4105MYN Zinc uptake regulation protein EPG46_RS20110 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EPG46_RS20115 ENOG4105P4Z Phage shock protein G EPG46_RS20120 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EPG46_RS20125 ENOG4105CDU Replicative dna helicase EPG46_RS20130 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EPG46_RS20135 ENOG4105CGF Aromatic amino acid aminotransferase EPG46_RS20145 ENOG4105F0S class B acid phosphatase EPG46_RS20150 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EPG46_RS20155 ENOG4105MSB protein, conserved in bacteria EPG46_RS20160 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EPG46_RS20165 ENOG4108UUM single-stranded DNA-binding protein EPG46_RS20170 ENOG4105PMV Membrane EPG46_RS20175 ENOG4108M8H domain protein EPG46_RS20180 ENOG4108W3Q Transcriptional regulator EPG46_RS20185 ENOG4108Z4X TRANSCRIPTIONal EPG46_RS20190 ENOG4105C7N Xanthine uracil vitamin C permease EPG46_RS20195 ENOG4105EEQ Na H antiporter EPG46_RS20210 ENOG41062QD Membrane EPG46_RS20215 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EPG46_RS20225 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit EPG46_RS20230 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EPG46_RS20235 ENOG4105DVI reductase, NrfD EPG46_RS20240 ENOG4108QKW cytochrome c-type biogenesis protein EPG46_RS20250 ENOG4108W0S formate-dependent nitrite reductase complex EPG46_RS20255 ENOG4105CK2 sodium dicarboxylate symporter EPG46_RS20260 ENOG41082ND Uncharacterized protein yjcO EPG46_RS20270 ENOG4105ETP RND efflux system, outer membrane lipoprotein EPG46_RS20275 ENOG4108MI0 Resistance protein EPG46_RS20280 ENOG4105J12 Multidrug resistance protein mdtN EPG46_RS20285 ENOG4106833 EPG46_RS20290 ENOG4105EUZ Beta-lactamase domain protein EPG46_RS20295 ENOG4107TFG D-allose kinase EPG46_RS20300 ENOG4105UP7 3-epimerase EPG46_RS20305 ENOG4105CNN ABC, transporter EPG46_RS20315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EPG46_RS20320 ENOG4105NYY transcriptional regulator, RpiR EPG46_RS20325 ENOG4108YZG isomerase EPG46_RS20335 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein EPG46_RS20340 ENOG410849A acetyltransferase, (GNAT) family EPG46_RS20345 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) EPG46_RS20350 ENOG4105FD8 phosphonate metabolism protein PhnM EPG46_RS20355 ENOG4105HRV phosphonate c-p lyase system protein phnl EPG46_RS20360 ENOG4105ENV phosphonate C-P lyase system protein PhnK EPG46_RS20365 ENOG4105FT8 Phosphonate metabolism EPG46_RS20370 ENOG4105EKV Phosphonate metabolism protein EPG46_RS20375 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH EPG46_RS20380 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG EPG46_RS20385 ENOG4107RJJ Transcriptional regulator EPG46_RS20395 ENOG4105EHI Phosphonate ABC transporter, periplasmic EPG46_RS20400 ENOG4105D5T phosphonate abc transporter EPG46_RS20405 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase EPG46_RS20410 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EPG46_RS20415 ENOG4108F5E vimentin EPG46_RS20420 ENOG4108YIV EPG46_RS20425 ENOG4105CSH Transporter EPG46_RS20435 ENOG4105ECM Sensor protein basS pmrB EPG46_RS20440 ENOG4105XJC Two component transcriptional regulator (Winged helix family EPG46_RS20445 ENOG4105DIJ Phosphoethanolamine transferase EPG46_RS20450 ENOG4105D5Q Arginine ornithine antiporter EPG46_RS20455 ENOG4106ZGR Transcriptional regulator EPG46_RS20460 ENOG4105CXN decarboxylase EPG46_RS20465 ENOG4108K2B transcriptional regulator EPG46_RS20470 ENOG4105F8D glycoside hydrolase family 4 EPG46_RS20475 ENOG4105CT4 transporter EPG46_RS20480 ENOG4108R5S membrane EPG46_RS20485 ENOG4107GFK fumarate EPG46_RS20490 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EPG46_RS20495 ENOG4108MRH transcriptional regulatory protein EPG46_RS20500 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EPG46_RS20505 ENOG4105VR1 Pfam:DUF1271 EPG46_RS20510 ENOG410830R acetyltransferase EPG46_RS20525 ENOG4108SIC Transcriptional regulator EPG46_RS20530 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EPG46_RS20540 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EPG46_RS20545 ENOG4108IJ0 Aspartate ammonia-lyase EPG46_RS20550 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 EPG46_RS20555 ENOG4105DVH amino acid EPG46_RS20570 ENOG4108ZVF (LipO)protein EPG46_RS20575 ENOG4105MTB Uncharacterized protein YjeJ EPG46_RS20580 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EPG46_RS20590 ENOG4107PEH Entericidin EcnA/B family EPG46_RS20595 ENOG4106BSU Entericidin B EPG46_RS20600 ENOG4105KPY Small multidrug resistance protein EPG46_RS20605 ENOG4105QNF Outer membrane lipoprotein EPG46_RS20610 ENOG41066YJ Beta-lactamase EPG46_RS20625 ENOG4105E33 succinate dehydrogenase EPG46_RS20630 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EPG46_RS20635 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EPG46_RS20640 ENOG4107SC7 Inner membrane transporter yjeM EPG46_RS20645 ENOG4106V5W EPG46_RS20650 ENOG4106CG8 Inner membrane protein YjeO EPG46_RS20655 ENOG4105EGS Mechanosensitive ion channel EPG46_RS20695 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EPG46_RS20700 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EPG46_RS20705 ENOG4105K8N protein family UPF0079, ATPase EPG46_RS20710 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EPG46_RS20715 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EPG46_RS20730 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EPG46_RS20735 ENOG4107QJR hflk protein EPG46_RS20740 ENOG4105EPW hflc protein EPG46_RS20760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EPG46_RS20765 ENOG4105C2N RNA methyltransferase TrmH family group 3 EPG46_RS20770 ENOG4107HP6 Transcriptional regulator EPG46_RS20775 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EPG46_RS20780 ENOG4105CSP Major Facilitator Superfamily EPG46_RS20785 ENOG4105CTX dehydratase EPG46_RS20800 ENOG4107VNS Protein of unknown function (DUF2491) EPG46_RS20805 ENOG4105Z6B inner membrane protein yjfl EPG46_RS20810 ENOG4108KXT Conserved Protein EPG46_RS20815 ENOG4106032 Glutathionylspermidine synthase EPG46_RS20820 ENOG4105CSU acyl-Coa dehydrogenase EPG46_RS20825 ENOG4105S17 UPF0379 protein yjfN EPG46_RS20830 ENOG4105WSB biofilm stress and motility protein A EPG46_RS20835 ENOG4108MXZ Esterase EPG46_RS20855 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport EPG46_RS20860 ENOG4106ETB IIa component EPG46_RS20875 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EPG46_RS20880 ENOG4105R3P Inner membrane protein yagU EPG46_RS20885 ENOG4105KIT UPF0379 protein yjfY EPG46_RS20900 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EPG46_RS20915 ENOG4108RS6 transposase EPG46_RS20920 ENOG4105D7V transposase EPG46_RS20930 ENOG4105FHY Opacity-associated protein A EPG46_RS20935 ENOG4108V1T peptidylprolyl cis-trans isomerase EPG46_RS20940 ENOG4105C85 amino acid EPG46_RS20950 ENOG4105DXC membrane EPG46_RS20955 ENOG4105ECR NmrA family EPG46_RS20960 ENOG4105KVH Transcriptional regulator EPG46_RS20965 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EPG46_RS20970 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EPG46_RS21000 ENOG4108UUE Transcriptional regulator EPG46_RS21005 ENOG41061GZ Protein of unknown function (DUF1107) EPG46_RS21010 ENOG4105C37 (CBS) domain EPG46_RS21020 ENOG4105CFU surface antigen EPG46_RS21025 ENOG4105MA0 exported protein EPG46_RS21030 ENOG4108ZHD aig2 family EPG46_RS21035 ENOG41087RY SpoVT_AbrB EPG46_RS21040 ENOG4105MZG transcriptional modulator of maze toxin, mazf EPG46_RS21045 ENOG4105F0N pyrophosphate phospho-hydrolase EPG46_RS21050 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EPG46_RS21055 ENOG4105C2J ABC transporter EPG46_RS21060 ENOG4107R9N ABC transporter EPG46_RS21065 ENOG41062B0 ABC transporter, permease EPG46_RS21075 ENOG4105DFU Cell wall formation (By similarity) EPG46_RS21085 ENOG4105CMS peptidase U62, modulator of DNA gyrase EPG46_RS21095 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) EPG46_RS21100 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EPG46_RS21105 ENOG4105CG3 alpha amylase, catalytic region EPG46_RS21110 ENOG4105C5Y PTS System EPG46_RS21115 ENOG4105D4X repressor EPG46_RS21125 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EPG46_RS21130 ENOG4105KME endoribonuclease L-psp EPG46_RS21145 ENOG4107C93 pyrBI operon leader peptide EPG46_RS21150 ENOG4108UQ8 endoribonuclease L-psp EPG46_RS21155 ENOG4105F6U Short-chain dehydrogenase reductase Sdr EPG46_RS21160 ENOG4108XFH Transcriptional regulator EPG46_RS21165 ENOG4105XEP YhcH YjgK YiaL family protein EPG46_RS21180 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) EPG46_RS21185 ENOG4108MJ3 acetyltransferase EPG46_RS21190 ENOG4108M3P Membrane EPG46_RS21195 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EPG46_RS21200 ENOG4105MYG DNA polymerase iii, chi subunit EPG46_RS21210 ENOG4108M8S permease YjgP YjgQ family protein EPG46_RS21215 ENOG4108K5H permease YjgP YjgQ family protein EPG46_RS21220 ENOG4105D7A ATP-binding protein EPG46_RS21225 ENOG4105K2J Transcriptional regulator EPG46_RS21230 ENOG4105C6Z Gluconate EPG46_RS21235 ENOG4105CHR reductase EPG46_RS21240 ENOG4105CPQ Dehydrogenase EPG46_RS21245 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EPG46_RS21250 ENOG4105DQ4 alcohol dehydrogenase EPG46_RS21280 ENOG4105VNT transposase (IS4 family) protein EPG46_RS21285 ENOG4105JHE Major Facilitator Superfamily EPG46_RS21290 ENOG4107RJ5 oxidoreductase EPG46_RS21320 ENOG4105E0A ABC, transporter EPG46_RS21325 ENOG4108IHU transport system permease protein EPG46_RS21330 ENOG4105DQ5 transport system permease protein EPG46_RS21335 ENOG4108HUF Transporter EPG46_RS21340 ENOG4105GAV receptor EPG46_RS21345 ENOG4108S3W Anti-feci sigma factor, fecr EPG46_RS21350 ENOG4108SF5 RNA Polymerase EPG46_RS21390 ENOG4108YXQ IS66 Orf2 family protein EPG46_RS21430 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) EPG46_RS21435 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria EPG46_RS21440 ENOG4108W9T type 1 fimbriae regulatory protein EPG46_RS21445 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off EPG46_RS21455 ENOG4108S54 Fimbrial protein EPG46_RS21460 ENOG4108NAE Fimbrial chaperone protein EPG46_RS21465 ENOG4105CW0 outer membrane usher protein EPG46_RS21470 ENOG4108SQA Fimbrial EPG46_RS21475 ENOG4108T65 Fimbrial EPG46_RS21480 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin EPG46_RS21485 ENOG4107EFN gluconate transport system permease 3 EPG46_RS21495 ENOG4105DEI Mannitol dehydrogenase EPG46_RS21500 ENOG4105C6F GntR Family Transcriptional Regulator EPG46_RS21520 ENOG4107YNJ LysR family Transcriptional regulator EPG46_RS21525 ENOG4105DYB Isoaspartyl dipeptidase EPG46_RS21530 ENOG4108P2H Inner membrane protein YjiG EPG46_RS21535 ENOG41074DU domain protein EPG46_RS21545 ENOG4105CBP Major Facilitator EPG46_RS21560 ENOG4105CIZ coA-substrate-specific enzyme activase EPG46_RS21565 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase EPG46_RS21570 ENOG4106BRA Membrane EPG46_RS21575 ENOG41083G8 Multidrug resistance protein MdtM EPG46_RS21600 ENOG4105CKI cobalamin synthesis protein EPG46_RS21605 ENOG4105VCD cytoplasmic protein EPG46_RS21610 ENOG4105D22 carbon starvation protein EPG46_RS21615 ENOG4105C8Q Methyl-accepting chemotaxis EPG46_RS21620 ENOG4108I5G Major Facilitator superfamily EPG46_RS21625 ENOG410617M Transcriptional regulator EPG46_RS21635 ENOG4105CPQ Dehydrogenase EPG46_RS21645 ENOG4105RI1 glycoprotein receptor EPG46_RS21650 ENOG4106CVF DNA replication protein EPG46_RS21665 ENOG4105DWK Membrane EPG46_RS21670 ENOG4108N8T regulatoR EPG46_RS21675 ENOG4108T94 DNA-binding transcriptional activator BglJ EPG46_RS21680 ENOG4108819 ferric iron reductase EPG46_RS21685 ENOG4105YBH Protein of unknown function (DUF1435) EPG46_RS21705 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EPG46_RS21710 ENOG4108WPU DNA polymerase III subunit psi EPG46_RS21715 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EPG46_RS21720 ENOG4105PAD Hydrolase EPG46_RS21740 ENOG41077V0 CPS-53 (KpLE1) prophage EPG46_RS21745 ENOG4108R7K Metal Dependent Phosphohydrolase EPG46_RS21750 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) EPG46_RS21755 ENOG4105H40 EPG46_RS21760 ENOG4105RDA repressor EPG46_RS21765 ENOG41078CG DNA-binding transcriptional regulator EPG46_RS21770 ENOG4108S1U EPG46_RS21800 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) EPG46_RS21810 ENOG4108MXB Protein of unknown function (DUF968) EPG46_RS21815 ENOG4105HGD Antitermination protein EPG46_RS21835 ENOG4105QFS Lysis protein S homolog from lambdoid prophage EPG46_RS21840 ENOG4105KUS lysozyme EPG46_RS21845 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 EPG46_RS21875 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EPG46_RS21950 ENOG4108X9F tail fiber protein EPG46_RS21980 ENOG4106FE3 DNA repair EPG46_RS21995 ENOG4105K3G Periplasmic Protein EPG46_RS22005 ENOG4108NRW Phospholipase, patatin family EPG46_RS22010 ENOG4105EYA deoxyribonuclease EPG46_RS22015 ENOG41076CZ activating enzyme EPG46_RS22020 ENOG4105G0K glycine radical enzyme YjjI family EPG46_RS22045 ENOG4105EUP HipA domain protein EPG46_RS22055 ENOG41062Z9 Membrane EPG46_RS22060 ENOG4105EAC phosphoserine phosphatase EPG46_RS22065 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EPG46_RS22070 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase EPG46_RS22075 ENOG4105C5H ABC transporter EPG46_RS22080 ENOG4107SC1 transglycosylase EPG46_RS22090 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EPG46_RS22100 ENOG4105UEI Transcriptional Regulator AraC Family EPG46_RS22105 ENOG4108RH0 Crea protein EPG46_RS22110 ENOG4105E3W Two component transcriptional regulator (Winged helix family EPG46_RS22115 ENOG4105EB3 Histidine kinase EPG46_RS22120 ENOG4105CT7 inner membrane cred family protein EPG46_RS22125 ENOG41065U4 response regulator EPG46_RS22130 ENOG410759A EPG46_RS22135 ENOG4106FVC RNA methyltransferase EPG46_RS22145 ENOG4105CFH Aspartokinase EPG46_RS22155 ENOG4105D98 threonine synthase EPG46_RS22160 ENOG41062C6 Protein of unknown function (DUF2502) EPG46_RS22170 ENOG4105BZG amino acid carrier protein EPG46_RS22180 ENOG4108RIR Molybdenum cofactor biosynthesis protein EPG46_RS22185 ENOG4106HK8 GPR1 FUN34 yaaH family protein EPG46_RS22190 ENOG4108QUJ UPF0174 protein YaaW EPG46_RS22195 ENOG4108WTA UPF0412 protein YaaI EPG46_RS22210 ENOG4105WI6 cell killing protein encoded within cryptic prophage EPG46_RS22220 ENOG41063Z6 transcriptional regulator, lysR family EPG46_RS22230 ENOG4105CW0 outer membrane usher protein EPG46_RS22235 ENOG4108MQF Chaperone EPG46_RS22255 ENOG410647N response to DNA damage stimulus EPG46_RS22260 ENOG4105DTN riboflavin biosynthesis protein ribF EPG46_RS22265 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EPG46_RS22275 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EPG46_RS22290 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EPG46_RS22295 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EPG46_RS22300 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EPG46_RS22305 ENOG4108XNW Transcriptional activatory protein CaiF EPG46_RS22315 ENOG4106YT9 Enoyl-CoA hydratase EPG46_RS22345 ENOG4105C10 Electron transfer flavoprotein EPG46_RS22350 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EPG46_RS22355 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein EPG46_RS22360 ENOG4105C54 Major Facilitator superfamily EPG46_RS22370 ENOG4105CKD glutathione-regulated potassium-efflux system protein EPG46_RS22375 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EPG46_RS22380 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EPG46_RS22395 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EPG46_RS22400 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EPG46_RS22405 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EPG46_RS22410 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) EPG46_RS22430 ENOG4105D3G Pseudouridine synthase EPG46_RS22435 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EPG46_RS22440 ENOG4105CQ2 DNA polymerase EPG46_RS22445 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EPG46_RS22450 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EPG46_RS22455 ENOG4105EF1 ribulokinase EPG46_RS22460 ENOG41063TF transcriptional regulator (AraC EPG46_RS22465 ENOG4108KF1 Membrane EPG46_RS22470 ENOG4107T0D ABC, transporter EPG46_RS22475 ENOG4106SMU thiamine transporter membrane protein EPG46_RS22480 ENOG4105DP9 ABC transporter EPG46_RS22485 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EPG46_RS22495 ENOG4105S8Q sugar efflux transporter EPG46_RS22510 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EPG46_RS22525 ENOG41064T2 transcriptional regulator, lysR family EPG46_RS22535 ENOG4105C7K acetolactate synthase EPG46_RS22540 ENOG4108ZP8 Acetolactate synthase small subunit EPG46_RS22550 ENOG4107B7Y DNA-binding transcriptional regulator FruR EPG46_RS22555 ENOG4108V6E Cell division protein mraZ EPG46_RS22565 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EPG46_RS22570 ENOG4105CJN penicillin-binding protein EPG46_RS22575 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EPG46_RS22580 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EPG46_RS22595 ENOG4105CNI cell division protein FtsW EPG46_RS22610 ENOG4105CPF Cell wall formation (By similarity) EPG46_RS22615 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EPG46_RS22620 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EPG46_RS22625 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EPG46_RS22635 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) EPG46_RS22645 ENOG4105M6F mutator MutT protein EPG46_RS22660 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EPG46_RS22675 ENOG4105D7Q type ii secretion system EPG46_RS22680 ENOG4107QHF type ii secretion system protein e EPG46_RS22685 ENOG4108ZUW Major pilin subunit EPG46_RS22690 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EPG46_RS22695 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EPG46_RS22700 ENOG4106A72 regulatory protein AmpE EPG46_RS22705 ENOG4105C85 amino acid EPG46_RS22710 ENOG41073TP transcriptional regulator EPG46_RS22715 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EPG46_RS22720 ENOG4107QSN dihydrolipoamide acetyltransferase EPG46_RS22725 ENOG4107QN2 dihydrolipoyl dehydrogenase EPG46_RS22730 ENOG4108NST exported protein EPG46_RS22735 ENOG4107QIJ Aconitate hydratase 2 EPG46_RS22755 ENOG4108ZRK uncharacterized protein yacC EPG46_RS22760 ENOG4105E3B Multicopper oxidase EPG46_RS22765 ENOG4105DZG Dehydrogenase EPG46_RS22770 ENOG4108UGV hypoxanthine phosphoribosyltransferase EPG46_RS22775 ENOG41077A9 carbonic anhydrase EPG46_RS22780 ENOG4105DA5 (ABC) transporter EPG46_RS22785 ENOG4105E3A (ABC) transporter EPG46_RS22790 ENOG4108YTN IIa component EPG46_RS22795 ENOG4107BJW polysaccharide deacetylase EPG46_RS22805 ENOG4108A32 Transposase EPG46_RS22815 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EPG46_RS22820 ENOG4105P0Q fimbrial-like protein YadC EPG46_RS22825 ENOG4105SN2 fimbrial-like adhesin protein EPG46_RS22830 ENOG4105SYG Fimbrial protein EPG46_RS22835 ENOG4108XEY fimbrial-like adhesin protein EPG46_RS22840 ENOG4105CW0 outer membrane usher protein EPG46_RS22845 ENOG4108VEV chaperone EPG46_RS22855 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EPG46_RS22860 ENOG4105DJ0 Poly(A) Polymerase EPG46_RS22880 ENOG4107XID 2'-5' rna ligase EPG46_RS22885 ENOG4105CQ7 ATP-dependent helicase EPG46_RS22890 ENOG4105BZ4 penicillin-binding protein EPG46_RS22895 ENOG4105E0K tonB-dependent siderophore receptor EPG46_RS22900 ENOG4105E0A ABC, transporter EPG46_RS22905 ENOG4105J76 Periplasmic binding protein EPG46_RS22910 ENOG4105S6R Iron-hydroxamate transporter permease subunit EPG46_RS22935 ENOG4105EN6 Membrane EPG46_RS22940 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EPG46_RS22955 ENOG4105C0H protease EPG46_RS22960 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EPG46_RS22970 ENOG4105DIN metallophosphoesterase EPG46_RS22980 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EPG46_RS22985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EPG46_RS23010 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EPG46_RS23015 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EPG46_RS23020 ENOG4105KNE Phosphatidate cytidylyltransferase EPG46_RS23025 ENOG4105DZP Membrane-associated zinc metalloprotease EPG46_RS23035 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) EPG46_RS23040 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EPG46_RS23065 ENOG4105C0B DNA polymerase III (alpha subunit) EPG46_RS23075 ENOG4105CXN decarboxylase EPG46_RS23080 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EPG46_RS23085 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EPG46_RS23090 ENOG4105M1T rho-binding antiterminator EPG46_RS23100 ENOG4108VWS Yaeq family EPG46_RS23105 ENOG4108YZN class I peptide chain release factor EPG46_RS23110 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion EPG46_RS23115 ENOG4108UY0 (LipO)protein EPG46_RS23125 ENOG4108R96 Methyltransferase, YaeB family EPG46_RS23130 ENOG4108R8X outer membrane lipoprotein EPG46_RS23135 ENOG4105D01 (LipO)protein EPG46_RS23140 ENOG4108UMI ABC transporter, permease EPG46_RS23145 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EPG46_RS23150 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EPG46_RS23190 ENOG41074AV Hok/gef family EPG46_RS23245 ENOG4105EKQ RNA-directed DNA polymerase EPG46_RS23265 ENOG4106JQ7 EPG46_RS23270 ENOG41073YN Protein of unknown function (DUF1380) EPG46_RS23310 ENOG4105ESI atpase involved in dna repair EPG46_RS23335 ENOG4108BUD transposase EPG46_RS23375 ENOG4105EPC oxidoreductase EPG46_RS23380 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EPG46_RS23400 ENOG4108BUD transposase EPG46_RS23435 ENOG4108BUD transposase EPG46_RS23455 ENOG4108BUD transposase EPG46_RS23520 ENOG4106CQM replication EPG46_RS23530 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) EPG46_RS23545 ENOG4105KK6 nuclease EPG46_RS23560 ENOG4107CBI conjugal transfer fertility inhibition protein EPG46_RS23565 ENOG4107U2T alpha beta EPG46_RS23760 ENOG4105VGJ Virulence-associated protein EPG46_RS23765 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A EPG46_RS23810 ENOG4108YXQ IS66 Orf2 family protein EPG46_RS23990 ENOG4105WBN Transcriptional regulator (LacI family EPG46_RS24080 ENOG4108ZHR arsR family transcriptional regulator EPG46_RS24125 ENOG4105F2I Transposase EPG46_RS24225 ENOG4105ESI atpase involved in dna repair EPG46_RS24255 ENOG4106JVB Replication Protein EPG46_RS24385 ENOG4105C94 Transporter EPG46_RS24400 ENOG4108BUD transposase EPG46_RS24475 ENOG4107CBI conjugal transfer fertility inhibition protein EPG46_RS24500 ENOG4108X9F tail fiber protein EPG46_RS24510 ENOG4105UZW Tail fiber assembly protein EPG46_RS24515 ENOG4108US3 tail fiber assembly EPG46_RS24525 ENOG4108C33 Resolvase EPG46_RS24560 ENOG4105D7V transposase EPG46_RS24585 ENOG4108UUM single-stranded DNA-binding protein EPG46_RS24695 ENOG4105KT5 UmuD protein EPG46_RS24705 ENOG4105MPK DNA polymerase III subunit theta EPG46_RS24795 ENOG4108R1E Serine threonine protein phosphatase 1 EPG46_RS24855 ENOG4105CDU Replicative dna helicase EPG46_RS24880 ENOG4105DFE Dna adenine methylase EPG46_RS24885 ENOG4105DH7 May be involved in recombination (By similarity) EPG46_RS25030 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division