locus-tag	class	description
HO398_RS00010	COG0460	homoserine dehydrogenase
HO398_RS00010	COG0527	aspartate kinase activity
HO398_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HO398_RS00035	COG1115	amino acid carrier protein
HO398_RS00045	COG0521	Mo-molybdopterin cofactor biosynthetic process
HO398_RS00050	COG1584	GPR1 FUN34 yaaH family protein
HO398_RS00055	COG4735	regulation of single-species biofilm formation
HO398_RS00075	COG3385	transposase activity
HO398_RS00090	COG0583	DNA-binding transcription factor activity
HO398_RS00130	COG0196	riboflavin kinase activity
HO398_RS00145	COG1047	Peptidyl-prolyl cis-trans
HO398_RS00165	COG0505	Belongs to the CarA family
HO398_RS00170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HO398_RS00220	COG0644	oxidoreductase
HO398_RS00225	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HO398_RS00230	COG2271	Major facilitator Superfamily
HO398_RS00245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HO398_RS00270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HO398_RS00275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HO398_RS00280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HO398_RS00285	COG0564	pseudouridine synthase activity
HO398_RS00295	COG0417	DNA replication proofreading
HO398_RS00300	COG0235	Class ii aldolase
HO398_RS00315	COG4977	sequence-specific DNA binding
HO398_RS00320	COG0586	Pfam SNARE associated Golgi protein
HO398_RS00330	COG1178	ABC-type Fe3 transport system permease component
HO398_RS00335	COG4143	(ABC) transporter
HO398_RS00350	COG2814	Major facilitator Superfamily
HO398_RS00365	COG0473	3-isopropylmalate dehydrogenase activity
HO398_RS00380	COG0583	DNA-binding transcription factor activity
HO398_RS00385	COG0028	Belongs to the TPP enzyme family
HO398_RS00390	COG0440	acetolactate synthase activity
HO398_RS00400	COG1609	Transcriptional regulator
HO398_RS00415	COG3116	cell division
HO398_RS00420	COG0768	penicillin binding
HO398_RS00425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HO398_RS00430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HO398_RS00440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HO398_RS00445	COG0772	Belongs to the SEDS family
HO398_RS00460	COG1181	Belongs to the D-alanine--D-alanine ligase family
HO398_RS00465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HO398_RS00470	COG0849	cell division
HO398_RS00475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HO398_RS00495	COG0494	nUDIX hydrolase
HO398_RS00510	COG0237	dephospho-CoA kinase activity
HO398_RS00520	COG1459	type II secretion system
HO398_RS00525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HO398_RS00530	COG4969	Belongs to the N-Me-Phe pilin family
HO398_RS00535	COG0157	Belongs to the NadC ModD family
HO398_RS00540	COG3023	N-Acetylmuramoyl-L-alanine amidase
HO398_RS00545	COG3725	Membrane protein required for beta-lactamase induction
HO398_RS00550	COG1113	amino acid transport
HO398_RS00555	COG2186	Transcriptional regulator
HO398_RS00560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HO398_RS00565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HO398_RS00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HO398_RS00575	COG3064	Membrane
HO398_RS00580	COG1049	propionate catabolic process, 2-methylcitrate cycle
HO398_RS00605	COG2132	Multicopper oxidase
HO398_RS00610	COG4993	Dehydrogenase
HO398_RS00615	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HO398_RS00630	COG1131	(ABC) transporter
HO398_RS00635	COG0842	Transport permease protein
HO398_RS00640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS00645	COG0726	polysaccharide deacetylase
HO398_RS00655	COG5464	transposase or invertase
HO398_RS00670	COG3539	Fimbrial protein
HO398_RS00675	COG3539	Fimbrial protein
HO398_RS00680	COG3539	Fimbrial protein
HO398_RS00685	COG3539	Fimbrial protein
HO398_RS00690	COG3188	usher protein
HO398_RS00695	COG3121	Chaperone
HO398_RS00700	COG3539	Fimbrial protein
HO398_RS00705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HO398_RS00710	COG0617	tRNA 3'-terminal CCA addition
HO398_RS00720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HO398_RS00730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HO398_RS00735	COG1643	Atp-dependent helicase
HO398_RS00740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HO398_RS00760	COG1120	ATPase activity
HO398_RS00765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HO398_RS00770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO398_RS00795	COG2860	membrane
HO398_RS00800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HO398_RS00815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HO398_RS00820	COG3835	regulator
HO398_RS00830	COG1408	metallophosphoesterase
HO398_RS00845	COG0024	Methionine aminopeptidase
HO398_RS00870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HO398_RS00875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HO398_RS00880	COG0575	Belongs to the CDS family
HO398_RS00885	COG0750	zinc metalloprotease
HO398_RS00895	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HO398_RS00900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HO398_RS00925	COG0587	DNA-directed DNA polymerase activity
HO398_RS00940	COG0346	lactoylglutathione lyase activity
HO398_RS00945	COG0037	tRNA processing
HO398_RS00950	COG4568	rho-dependent transcription termination
HO398_RS00960	COG4681	YaeQ
HO398_RS00965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HO398_RS00970	COG3015	lipoprotein NlpE involved in copper resistance
HO398_RS00975	COG0791	NLP P60 protein
HO398_RS00985	COG1720	tRNA m6t6A37 methyltransferase activity
HO398_RS00995	COG1464	Belongs to the NlpA lipoprotein family
HO398_RS01000	COG2011	ABC-type metal ion transport system permease component
HO398_RS01005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HO398_RS01010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HO398_RS01045	COG0656	L-ascorbic acid biosynthetic process
HO398_RS01050	COG0583	DNA-binding transcription factor activity
HO398_RS01065	COG1388	LysM domain
HO398_RS01065	COG0741	lytic transglycosylase activity
HO398_RS01075	COG2226	methyltransferase
HO398_RS01085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HO398_RS01110	COG5433	transposase activity
HO398_RS01115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HO398_RS01125	COG1960	acyl-CoA dehydrogenase activity
HO398_RS01135	COG0121	glutamine amidotransferase
HO398_RS01140	COG3034	peptidoglycan biosynthetic process
HO398_RS01145	COG3041	Addiction module toxin RelE StbE family
HO398_RS01150	COG3077	Addiction module antitoxin, RelB DinJ family
HO398_RS01155	COG0791	NLP P60 protein
HO398_RS01160	COG1943	Transposase
HO398_RS01180	COG2161	toxin-antitoxin pair type II binding
HO398_RS01190	COG0454	-acetyltransferase
HO398_RS01195	COG1690	Belongs to the RtcB family
HO398_RS01200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HO398_RS01205	COG2195	Cleaves the N-terminal amino acid of tripeptides
HO398_RS01230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HO398_RS01250	COG0583	DNA-binding transcription factor activity
HO398_RS01255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HO398_RS01260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HO398_RS01265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HO398_RS01270	COG2080	2 iron, 2 sulfur cluster binding
HO398_RS01275	COG3477	response to acidic pH
HO398_RS01285	COG0727	PFAM Uncharacterised protein family (UPF0153)
HO398_RS01290	COG3121	Chaperone
HO398_RS01300	COG3188	usher protein
HO398_RS01345	COG2207	Transcriptional regulator
HO398_RS01345	COG3708	Transcriptional regulator
HO398_RS01355	COG3059	membrane
HO398_RS01365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HO398_RS01370	COG2207	Transcriptional regulator
HO398_RS01375	COG0247	lactate metabolic process
HO398_RS01380	COG1139	Iron-sulfur cluster binding protein
HO398_RS01385	COG1556	Lactate utilization protein
HO398_RS01410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HO398_RS01420	COG2200	EAL domain
HO398_RS01420	COG2771	luxR family
HO398_RS01425	COG0583	DNA-binding transcription factor activity
HO398_RS01435	COG0666	response to abiotic stimulus
HO398_RS01445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HO398_RS01450	COG1304	FMN binding
HO398_RS01460	COG0549	Belongs to the carbamate kinase family
HO398_RS01465	COG0402	S-adenosylhomocysteine deaminase activity
HO398_RS01470	COG1064	alcohol dehydrogenase
HO398_RS01485	COG1280	lysine exporter protein (LysE YggA)
HO398_RS01495	COG3829	transcription factor binding
HO398_RS01500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HO398_RS01505	COG0372	Belongs to the citrate synthase family
HO398_RS01510	COG2079	MmgE PrpD family protein
HO398_RS01515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HO398_RS01520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HO398_RS01525	COG0402	S-adenosylhomocysteine deaminase activity
HO398_RS01530	COG0583	DNA-binding transcription factor activity
HO398_RS01535	COG0288	reversible hydration of carbon dioxide
HO398_RS01545	COG2807	transmembrane transport
HO398_RS01550	COG0110	maltose O-acetyltransferase activity
HO398_RS01555	COG2223	nitrite transmembrane transporter activity
HO398_RS01560	COG3250	beta-galactosidase activity
HO398_RS01565	COG1609	Transcriptional regulator
HO398_RS01570	COG1414	Transcriptional regulator
HO398_RS01590	COG3971	2-oxopent-4-enoate hydratase activity
HO398_RS01605	COG2814	Major facilitator Superfamily
HO398_RS01610	COG3122	Protein conserved in bacteria
HO398_RS01640	COG4521	taurine ABC transporter
HO398_RS01645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HO398_RS01650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HO398_RS01655	COG2175	clavaminate synthase activity
HO398_RS01660	COG0113	porphobilinogen synthase activity
HO398_RS01665	COG3468	outer membrane autotransporter barrel domain protein
HO398_RS01670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HO398_RS01675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HO398_RS01680	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HO398_RS01700	COG1181	Belongs to the D-alanine--D-alanine ligase family
HO398_RS01715	COG1785	Belongs to the alkaline phosphatase family
HO398_RS01725	COG3706	GGDEF domain
HO398_RS01730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HO398_RS01750	COG4126	flavin adenine dinucleotide binding
HO398_RS01780	COG1940	carbohydrate kinase activity
HO398_RS01785	COG2814	Major facilitator Superfamily
HO398_RS01790	COG0419	ATPase involved in DNA repair
HO398_RS01795	COG0420	3'-5' exonuclease activity
HO398_RS01800	COG0745	RESPONSE REGULATOR receiver
HO398_RS01805	COG5002	protein histidine kinase activity
HO398_RS01810	COG1114	Component of the transport system for branched-chain amino acids
HO398_RS01815	COG1113	amino acid transport
HO398_RS01820	COG0366	Alpha amylase catalytic
HO398_RS01840	COG1862	Preprotein translocase
HO398_RS01845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HO398_RS01850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HO398_RS01855	COG1403	HNH endonuclease
HO398_RS01860	COG3248	Nucleoside-binding outer membrane protein
HO398_RS01865	COG4238	major outer membrane lipoprotein
HO398_RS01875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HO398_RS01875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HO398_RS01890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HO398_RS01895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HO398_RS01900	COG0667	Aldo Keto reductase
HO398_RS01910	COG0142	geranyltranstransferase activity
HO398_RS01925	COG0693	protein deglycase activity
HO398_RS01930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HO398_RS01940	COG2814	Major facilitator Superfamily
HO398_RS01965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HO398_RS01970	COG1845	cytochrome c oxidase, subunit III
HO398_RS01975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HO398_RS01980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HO398_RS01985	COG2223	nitrite transmembrane transporter activity
HO398_RS01990	COG3056	Lipoprotein
HO398_RS01995	COG0271	Belongs to the BolA IbaG family
HO398_RS02015	COG3385	transposase activity
HO398_RS02020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HO398_RS02025	COG0776	regulation of translation
HO398_RS02030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HO398_RS02035	COG1555	photosystem II stabilization
HO398_RS02040	COG0824	Thioesterase
HO398_RS02050	COG4533	DNA binding
HO398_RS02060	COG1522	sequence-specific DNA binding
HO398_RS02065	COG1132	(ABC) transporter
HO398_RS02070	COG1132	(ABC) transporter
HO398_RS02075	COG0347	Belongs to the P(II) protein family
HO398_RS02080	COG0004	ammonium transporteR
HO398_RS02085	COG1946	Acyl-CoA thioesterase
HO398_RS02090	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HO398_RS02095	COG3695	enzyme binding
HO398_RS02105	COG5507	3-demethylubiquinone-9 3-methyltransferase
HO398_RS02110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HO398_RS02120	COG0110	maltose O-acetyltransferase activity
HO398_RS02135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HO398_RS02140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS02145	COG1309	transcriptional regulator
HO398_RS02150	COG1196	nuclear chromosome segregation
HO398_RS02150	COG3264	Mechanosensitive ion channel
HO398_RS02160	COG3923	Primosomal replication protein n
HO398_RS02165	COG2832	Protein of unknown function (DUF454)
HO398_RS02175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HO398_RS02210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS02215	COG4651	solute:proton antiporter activity
HO398_RS02215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HO398_RS02220	COG2223	nitrite transmembrane transporter activity
HO398_RS02225	COG0737	Belongs to the 5'-nucleotidase family
HO398_RS02230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HO398_RS02235	COG3735	TraB family
HO398_RS02240	COG3093	addiction module antidote protein HigA
HO398_RS02245	COG2217	Heavy metal translocating P-type atpase
HO398_RS02250	COG2066	Belongs to the glutaminase family
HO398_RS02255	COG0531	amino acid
HO398_RS02260	COG0789	Transcriptional regulator
HO398_RS02265	COG1585	Membrane protein implicated in regulation of membrane protease activity
HO398_RS02270	COG0330	HflC and HflK could
HO398_RS02275	COG4619	ABC transporter
HO398_RS02280	COG0390	transport system, permease component
HO398_RS02285	COG3118	belongs to the thioredoxin family
HO398_RS02290	COG0300	oxidoreductase activity
HO398_RS02295	COG2755	lipolytic protein G-D-S-L family
HO398_RS02300	COG4181	ATPase activity
HO398_RS02305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HO398_RS02310	COG3209	COG3209 Rhs family protein
HO398_RS02350	COG0583	DNA-binding transcription factor activity
HO398_RS02360	COG1414	Transcriptional regulator
HO398_RS02365	COG3960	tartronate-semialdehyde synthase activity
HO398_RS02370	COG3622	Belongs to the hyi family
HO398_RS02375	COG2084	Dehydrogenase
HO398_RS02380	COG1953	Uracil, thiamine, allantoin
HO398_RS02390	COG2233	PERMEase
HO398_RS02395	COG1929	Belongs to the glycerate kinase type-1 family
HO398_RS02400	COG3257	ureidoglycine aminohydrolase activity
HO398_RS02405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HO398_RS02410	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HO398_RS02415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HO398_RS02420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HO398_RS02430	COG0549	Belongs to the carbamate kinase family
HO398_RS02435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HO398_RS02440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HO398_RS02450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HO398_RS02460	COG1988	membrane-bound metal-dependent
HO398_RS02465	COG2501	S4 domain
HO398_RS02475	COG3539	Fimbrial protein
HO398_RS02480	COG3121	Chaperone
HO398_RS02485	COG3188	usher protein
HO398_RS02490	COG3539	Fimbrial protein
HO398_RS02495	COG3539	Fimbrial protein
HO398_RS02500	COG2197	response regulator
HO398_RS02510	COG0582	viral genome integration into host DNA
HO398_RS02540	COG2076	Multidrug Resistance protein
HO398_RS02550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HO398_RS02555	COG1881	PFAM PEBP family protein
HO398_RS02560	COG2207	Transcriptional regulator
HO398_RS02620	COG3772	lysozyme
HO398_RS02660	COG5002	protein histidine kinase activity
HO398_RS02665	COG0745	RESPONSE REGULATOR receiver
HO398_RS02670	COG1538	Outer membrane efflux protein
HO398_RS02675	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS02680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS02685	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HO398_RS02690	COG1113	amino acid transport
HO398_RS02695	COG0668	transmembrane transport
HO398_RS02700	COG0778	Nitroreductase
HO398_RS02705	COG2315	Protein conserved in bacteria
HO398_RS02730	COG2801	Transposase and inactivated derivatives
HO398_RS02740	COG3385	transposase activity
HO398_RS02745	COG2977	Belongs to the P-Pant transferase superfamily
HO398_RS02750	COG4771	TonB-dependent receptor
HO398_RS02755	COG2382	esterase
HO398_RS02760	COG3251	PFAM MbtH domain protein
HO398_RS02765	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HO398_RS02765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HO398_RS02770	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HO398_RS02775	COG1120	ATPase activity
HO398_RS02780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO398_RS02785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO398_RS02795	COG4592	Periplasmic binding protein
HO398_RS02800	COG1169	isochorismate synthase
HO398_RS02805	COG1021	2,3-dihydroxybenzoate-AMP ligase
HO398_RS02810	COG1535	isochorismatase
HO398_RS02810	COG3433	isochorismatase activity
HO398_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS02820	COG2050	protein possibly involved in aromatic compounds catabolism
HO398_RS02830	COG2879	small protein
HO398_RS02835	COG0371	Dehydrogenase
HO398_RS02840	COG0436	Aminotransferase
HO398_RS02845	COG1475	DNA binding
HO398_RS02860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HO398_RS02865	COG0450	alkyl hydroperoxide reductase
HO398_RS02870	COG3634	alkyl hydroperoxide reductase activity
HO398_RS02875	COG0589	response to stress
HO398_RS02880	COG1063	alcohol dehydrogenase
HO398_RS02885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HO398_RS02890	COG3719	Belongs to the RNase T2 family
HO398_RS02895	COG0471	metal ion transport
HO398_RS02910	COG3051	citrate lyase alpha subunit
HO398_RS02915	COG2301	Belongs to the HpcH HpaI aldolase family
HO398_RS02925	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HO398_RS02935	COG3290	protein histidine kinase activity
HO398_RS02940	COG4565	transcriptional regulatory protein
HO398_RS02945	COG3069	C4-dicarboxylate transmembrane transporter activity
HO398_RS02965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HO398_RS02970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HO398_RS02980	COG0583	DNA-binding transcription factor activity
HO398_RS02995	COG1686	Belongs to the peptidase S11 family
HO398_RS03000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HO398_RS03005	COG0772	Belongs to the SEDS family
HO398_RS03010	COG0768	penicillin binding
HO398_RS03020	COG0799	negative regulation of ribosome biogenesis
HO398_RS03025	COG0406	alpha-ribazole phosphatase activity
HO398_RS03035	COG1466	dna polymerase III delta subunit
HO398_RS03050	COG2888	peptidyl-tyrosine sulfation
HO398_RS03070	COG0443	Heat shock 70 kDa protein
HO398_RS03095	COG0765	amino acid transport
HO398_RS03100	COG0765	amino acid transport
HO398_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS03115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HO398_RS03120	COG4535	Mg2 and Co2 transporter CorC
HO398_RS03130	COG1702	phosphate starvation-inducible protein PhoH
HO398_RS03140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HO398_RS03180	COG0367	asparagine synthase
HO398_RS03185	COG0647	UMP catabolic process
HO398_RS03190	COG1940	carbohydrate kinase activity
HO398_RS03190	COG1846	Transcriptional regulator
HO398_RS03195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HO398_RS03205	COG2190	(PTS) system
HO398_RS03205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS03205	COG1263	PTS System
HO398_RS03225	COG0735	belongs to the Fur family
HO398_RS03235	COG0716	FMN binding
HO398_RS03245	COG0596	Alpha beta hydrolase
HO398_RS03250	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HO398_RS03255	COG0033	Phosphoglucomutase
HO398_RS03275	COG0531	amino acid
HO398_RS03280	COG1982	Orn Lys Arg decarboxylase major
HO398_RS03290	COG0745	RESPONSE REGULATOR receiver
HO398_RS03295	COG2205	protein histidine kinase activity
HO398_RS03340	COG3209	COG3209 Rhs family protein
HO398_RS03370	COG3272	Protein of unknown function (DUF1722)
HO398_RS03375	COG0415	Belongs to the DNA photolyase family
HO398_RS03385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HO398_RS03390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HO398_RS03395	COG1984	allophanate hydrolase subunit 2
HO398_RS03410	COG3180	Ammonia monooxygenase
HO398_RS03415	COG3539	Fimbrial protein
HO398_RS03420	COG3121	Chaperone
HO398_RS03425	COG3188	usher protein
HO398_RS03430	COG3539	Fimbrial protein
HO398_RS03435	COG0372	Belongs to the citrate synthase family
HO398_RS03445	COG2009	succinate dehydrogenase
HO398_RS03450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HO398_RS03455	COG1053	succinate dehydrogenase
HO398_RS03460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HO398_RS03465	COG0567	Dehydrogenase, E1 component
HO398_RS03470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HO398_RS03480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HO398_RS03485	COG2188	Transcriptional regulator
HO398_RS03490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS03490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS03490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS03495	COG0383	alpha-mannosidase activity
HO398_RS03500	COG1271	oxidase subunit
HO398_RS03505	COG1294	oxidase, subunit
HO398_RS03510	COG4890	Cyd operon protein YbgT
HO398_RS03515	COG3790	cyd operon protein YbgE
HO398_RS03520	COG0824	Thioesterase
HO398_RS03525	COG0811	peptide transport
HO398_RS03530	COG0848	biopolymer transport protein
HO398_RS03535	COG3064	Membrane
HO398_RS03545	COG2885	chlorophyll binding
HO398_RS03550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HO398_RS03595	COG3201	nicotinamide mononucleotide transporter
HO398_RS03600	COG1230	cation diffusion facilitator family transporter
HO398_RS03610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HO398_RS03625	COG4677	pectinesterase activity
HO398_RS03635	COG1609	Transcriptional regulator
HO398_RS03790	COG5562	phage envelope protein
HO398_RS03805	COG4220	transposase activity
HO398_RS03825	COG1030	water channel activity
HO398_RS03875	COG1196	nuclear chromosome segregation
HO398_RS03925	COG1881	PFAM PEBP family protein
HO398_RS03930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HO398_RS03945	COG2226	methyltransferase
HO398_RS03950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HO398_RS03960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HO398_RS03970	COG0521	Mo-molybdopterin cofactor biosynthetic process
HO398_RS03980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HO398_RS03985	COG0314	molybdopterin synthase activity
HO398_RS03990	COG0670	Belongs to the BI1 family
HO398_RS03995	COG0670	Belongs to the BI1 family
HO398_RS04000	COG0392	lysyltransferase activity
HO398_RS04005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HO398_RS04010	COG3568	Endonuclease Exonuclease Phosphatase
HO398_RS04020	COG0842	Transport permease protein
HO398_RS04025	COG0842	Transport permease protein
HO398_RS04030	COG1131	(ABC) transporter
HO398_RS04040	COG1309	transcriptional regulator
HO398_RS04045	COG0513	Belongs to the DEAD box helicase family
HO398_RS04050	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HO398_RS04055	COG1199	ATP-dependent helicase activity
HO398_RS04060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HO398_RS04065	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HO398_RS04075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HO398_RS04085	COG4774	siderophore transport
HO398_RS04100	COG0668	transmembrane transport
HO398_RS04105	COG1126	abc transporter atp-binding protein
HO398_RS04110	COG0765	amino acid transport
HO398_RS04115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS04125	COG5006	permease, DMT superfamily
HO398_RS04135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HO398_RS04140	COG2194	sulfuric ester hydrolase activity
HO398_RS04150	COG1321	iron dependent repressor
HO398_RS04155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HO398_RS04160	COG1376	ErfK ybiS ycfS ynhG family protein
HO398_RS04165	COG0488	(ABC) transporter
HO398_RS04175	COG0561	phosphatase activity
HO398_RS04180	COG1882	Formate acetyltransferase
HO398_RS04185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HO398_RS04190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HO398_RS04195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HO398_RS04200	COG0303	'Molybdopterin
HO398_RS04205	COG1446	asparaginase
HO398_RS04210	COG4172	Belongs to the ABC transporter superfamily
HO398_RS04215	COG0747	negative chemotaxis
HO398_RS04225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO398_RS04235	COG2199	diguanylate cyclase activity
HO398_RS04250	COG2133	pyrroloquinoline quinone binding
HO398_RS04255	COG0625	glutathione transferase activity
HO398_RS04260	COG1686	Belongs to the peptidase S11 family
HO398_RS04265	COG1349	DNA-binding transcription factor activity
HO398_RS04270	COG0671	phosphoesterase, PA-phosphatase related
HO398_RS04275	COG2814	Major facilitator Superfamily
HO398_RS04285	COG0561	phosphatase activity
HO398_RS04290	COG0738	Major facilitator superfamily
HO398_RS04295	COG3226	Transcriptional regulator
HO398_RS04305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HO398_RS04355	COG4695	Portal protein
HO398_RS04425	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HO398_RS04460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HO398_RS04470	COG0778	Nitroreductase
HO398_RS04485	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HO398_RS04490	COG3842	ATPase activity
HO398_RS04495	COG1176	ABC-type spermidine putrescine transport system, permease component I
HO398_RS04500	COG1177	transmembrane transport
HO398_RS04515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS04520	COG4160	amino acid transport
HO398_RS04525	COG4215	(ABC) transporter
HO398_RS04530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS04535	COG1126	abc transporter atp-binding protein
HO398_RS04550	COG3023	N-Acetylmuramoyl-L-alanine amidase
HO398_RS04555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HO398_RS04560	COG0702	epimerase
HO398_RS04565	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HO398_RS04570	COG0028	Belongs to the TPP enzyme family
HO398_RS04575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HO398_RS04585	COG2431	L-lysine efflux transmembrane transporter activity
HO398_RS04595	COG3593	DNA synthesis involved in DNA repair
HO398_RS04600	COG2990	Protein conserved in bacteria
HO398_RS04605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS04610	COG0577	efflux transmembrane transporter activity
HO398_RS04610	COG1136	(ABC) transporter
HO398_RS04615	COG1278	Cold shock
HO398_RS04625	COG0542	response to heat
HO398_RS04650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HO398_RS04655	COG4988	ABC transporter
HO398_RS04660	COG0492	ferredoxin-NADP+ reductase activity
HO398_RS04665	COG1522	sequence-specific DNA binding
HO398_RS04670	COG1178	ABC-type Fe3 transport system permease component
HO398_RS04670	COG1674	ftsk spoiiie
HO398_RS04680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HO398_RS04690	COG0243	molybdopterin cofactor binding
HO398_RS04695	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS04700	COG3302	dmso reductase anchor subunit
HO398_RS04705	COG1335	isochorismatase
HO398_RS04715	COG0531	amino acid
HO398_RS04720	COG0583	DNA-binding transcription factor activity
HO398_RS04725	COG2249	NAD(P)H dehydrogenase (quinone) activity
HO398_RS04730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HO398_RS04735	COG1882	Formate acetyltransferase
HO398_RS04740	COG2116	formate transmembrane transporter activity
HO398_RS04745	COG1944	ATP diphosphatase activity
HO398_RS04750	COG2323	membrane
HO398_RS04765	COG0501	Belongs to the peptidase M48B family
HO398_RS04775	COG0539	negative regulation of cytoplasmic translation
HO398_RS04785	COG2333	competence protein COMEC
HO398_RS04785	COG0658	competence protein
HO398_RS04790	COG1132	(ABC) transporter
HO398_RS04795	COG1663	tetraacyldisaccharide 4'-kinase activity
HO398_RS04800	COG3214	Protein conserved in bacteria
HO398_RS04815	COG3173	Aminoglycoside phosphotransferase
HO398_RS04820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HO398_RS04825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HO398_RS04835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HO398_RS04845	COG2989	Protein conserved in bacteria
HO398_RS04850	COG3108	Peptidase M15
HO398_RS04855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HO398_RS04860	COG1448	Aminotransferase
HO398_RS04865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HO398_RS04880	COG0308	aminopeptidase N
HO398_RS04885	COG1116	anion transmembrane transporter activity
HO398_RS04890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HO398_RS04900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HO398_RS04905	COG0431	NADPH-dependent FMN reductase
HO398_RS04910	COG3539	Fimbrial protein
HO398_RS04915	COG3121	Chaperone
HO398_RS04920	COG3188	usher protein
HO398_RS04925	COG3539	Fimbrial protein
HO398_RS04930	COG3539	Fimbrial protein
HO398_RS04935	COG3539	Fimbrial protein
HO398_RS04940	COG3121	Chaperone
HO398_RS04955	COG0633	Ferredoxin
HO398_RS04955	COG3217	Mosc domain protein beta barrel domain protein
HO398_RS04965	COG0488	(ABC) transporter
HO398_RS04970	COG2995	paraquat-inducible protein a
HO398_RS04975	COG3008	intermembrane lipid transfer
HO398_RS04975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HO398_RS04980	COG3009	Protein conserved in bacteria
HO398_RS04985	COG3130	regulation of translation
HO398_RS04995	COG1067	ATP-dependent peptidase activity
HO398_RS05005	COG2885	chlorophyll binding
HO398_RS05005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HO398_RS05015	COG3070	regulator of competence-specific genes
HO398_RS05020	COG1289	transmembrane transporter activity
HO398_RS05025	COG3304	Inner membrane component domain
HO398_RS05030	COG0210	DNA helicase
HO398_RS05045	COG1832	CoA-binding protein
HO398_RS05060	COG1254	Belongs to the acylphosphatase family
HO398_RS05070	COG0670	Belongs to the BI1 family
HO398_RS05080	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HO398_RS05085	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HO398_RS05090	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HO398_RS05095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HO398_RS05100	COG1999	signal sequence binding
HO398_RS05105	COG1773	rubredoxin
HO398_RS05110	COG1271	oxidase subunit
HO398_RS05115	COG1294	oxidase, subunit
HO398_RS05130	COG3206	protein involved in exopolysaccharide biosynthesis
HO398_RS05130	COG0489	protein tyrosine kinase activity
HO398_RS05135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HO398_RS05140	COG1596	polysaccharide export
HO398_RS05145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO398_RS05165	COG1278	Cold shock
HO398_RS05170	COG1278	Cold shock
HO398_RS05190	COG0348	domain, Protein
HO398_RS05195	COG2198	Histidine kinase
HO398_RS05195	COG0784	Response regulator, receiver
HO398_RS05195	COG2205	protein histidine kinase activity
HO398_RS05200	COG1879	ABC-type sugar transport system periplasmic component
HO398_RS05205	COG0745	RESPONSE REGULATOR receiver
HO398_RS05210	COG3005	denitrification pathway
HO398_RS05215	COG0243	molybdopterin cofactor binding
HO398_RS05255	COG3729	General stress protein
HO398_RS05260	COG2233	PERMEase
HO398_RS05285	COG1335	isochorismatase
HO398_RS05295	COG1309	transcriptional regulator
HO398_RS05300	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HO398_RS05300	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HO398_RS05300	COG0506	proline dehydrogenase activity
HO398_RS05310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HO398_RS05325	COG2822	iron ion transport
HO398_RS05330	COG2837	iron assimilation
HO398_RS05335	COG1702	phosphate starvation-inducible protein PhoH
HO398_RS05340	COG3658	cytochrome
HO398_RS05345	COG1215	transferase activity, transferring glycosyl groups
HO398_RS05350	COG0726	polysaccharide deacetylase
HO398_RS05350	COG1649	PFAM Uncharacterised BCR, COG1649
HO398_RS05355	COG0457	Tetratricopeptide repeat
HO398_RS05360	COG3706	GGDEF domain
HO398_RS05385	COG3381	protein complex oligomerization
HO398_RS05395	COG1462	curli production assembly transport component CsgG
HO398_RS05410	COG2197	response regulator
HO398_RS05435	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HO398_RS05440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HO398_RS05455	COG2943	transferase activity, transferring hexosyl groups
HO398_RS05460	COG5645	(Lipo)protein
HO398_RS05475	COG1560	Kdo2-lipid A biosynthetic process
HO398_RS05485	COG2353	YceI-like domain
HO398_RS05490	COG3038	cytochrome b561
HO398_RS05525	COG2999	glutathione oxidoreductase activity
HO398_RS05535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HO398_RS05545	COG0673	inositol 2-dehydrogenase activity
HO398_RS05550	COG0728	peptidoglycan biosynthetic process
HO398_RS05555	COG3418	PFAM FlgN family protein
HO398_RS05560	COG2747	anti-sigma28 factor FlgM
HO398_RS05565	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HO398_RS05570	COG1815	bacterial-type flagellum-dependent cell motility
HO398_RS05575	COG1558	bacterial-type flagellum-dependent cell motility
HO398_RS05580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HO398_RS05585	COG1749	Flagellar hook protein flgE
HO398_RS05590	COG4787	bacterial-type flagellum-dependent cell motility
HO398_RS05595	COG4786	Flagellar basal body rod
HO398_RS05610	COG1705	Flagellar rod assembly protein muramidase FlgJ
HO398_RS05610	COG3951	Flagellar rod assembly protein muramidase FlgJ
HO398_RS05615	COG1256	bacterial-type flagellum assembly
HO398_RS05620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HO398_RS05625	COG1530	ribonuclease E activity
HO398_RS05630	COG0564	pseudouridine synthase activity
HO398_RS05635	COG0424	maF-like protein
HO398_RS05640	COG1399	metal-binding, possibly nucleic acid-binding protein
HO398_RS05660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HO398_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS05675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HO398_RS05680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HO398_RS05685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HO398_RS05695	COG0470	DNA polymerase III
HO398_RS05700	COG0084	hydrolase, TatD family'
HO398_RS05705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS05705	COG1263	PTS System
HO398_RS05710	COG4773	Receptor
HO398_RS05715	COG0537	adenosine 5'-monophosphoramidase activity
HO398_RS05720	COG5633	Lipoprotein
HO398_RS05725	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HO398_RS05745	COG1252	NADH dehydrogenase
HO398_RS05750	COG3134	Outer membrane lipoprotein
HO398_RS05755	COG1309	transcriptional regulator
HO398_RS05765	COG1376	ErfK ybiS ycfS ynhG family protein
HO398_RS05765	COG1388	LysM domain
HO398_RS05770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HO398_RS05775	COG4763	Acyl-transferase
HO398_RS05780	COG4591	ABC-type transport system involved in lipoprotein release permease component
HO398_RS05790	COG4591	ABC-type transport system involved in lipoprotein release permease component
HO398_RS05810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HO398_RS05815	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HO398_RS05825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HO398_RS05830	COG1177	transmembrane transport
HO398_RS05850	COG2850	peptidyl-arginine hydroxylation
HO398_RS05855	COG2205	protein histidine kinase activity
HO398_RS05865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HO398_RS05885	COG1187	pseudouridine synthase activity
HO398_RS05890	COG0538	isocitrate dehydrogenase activity
HO398_RS05905	COG5562	phage envelope protein
HO398_RS05910	COG0789	Transcriptional regulator
HO398_RS05915	COG2200	EAL domain
HO398_RS05940	COG2200	EAL domain
HO398_RS05990	COG2894	cell division
HO398_RS06015	COG0179	Fumarylacetoacetate (FAA) hydrolase
HO398_RS06030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HO398_RS06035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HO398_RS06040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HO398_RS06055	COG2719	SpoVR family
HO398_RS06065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HO398_RS06075	COG1619	proteins homologs of microcin C7 resistance protein MccF
HO398_RS06085	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HO398_RS06105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO398_RS06105	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HO398_RS06105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS06110	COG1461	Dihydroxyacetone kinase
HO398_RS06115	COG2376	Dihydroxyacetone kinase
HO398_RS06120	COG3284	Transcriptional regulator
HO398_RS06125	COG3468	outer membrane autotransporter barrel domain protein
HO398_RS06130	COG0012	GTP binding
HO398_RS06145	COG0659	secondary active sulfate transmembrane transporter activity
HO398_RS06150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HO398_RS06175	COG2890	protein-(glutamine-N5) methyltransferase activity
HO398_RS06180	COG3094	Invasion gene expression up-regulator, SirB
HO398_RS06185	COG2912	Transglutaminase-like superfamily
HO398_RS06210	COG0387	Pfam Sodium calcium exchanger
HO398_RS06215	COG4572	Cation transport regulator
HO398_RS06220	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HO398_RS06225	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HO398_RS06230	COG4932	domain protein
HO398_RS06235	COG2197	response regulator
HO398_RS06240	COG3850	Histidine kinase
HO398_RS06245	COG2223	nitrite transmembrane transporter activity
HO398_RS06250	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HO398_RS06255	COG1140	nitrate reductase beta subunit
HO398_RS06260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HO398_RS06265	COG2181	nitrate reductase activity
HO398_RS06290	COG0788	formyltetrahydrofolate deformylase activity
HO398_RS06300	COG1752	Esterase of the alpha-beta hydrolase superfamily
HO398_RS06305	COG0745	RESPONSE REGULATOR receiver
HO398_RS06310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HO398_RS06320	COG1435	thymidine kinase activity
HO398_RS06325	COG1454	alcohol dehydrogenase
HO398_RS06325	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS06330	COG2095	MarC family integral membrane protein
HO398_RS06335	COG4166	transmembrane transport
HO398_RS06340	COG0601	transmembrane transport
HO398_RS06345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO398_RS06350	COG0444	Belongs to the ABC transporter superfamily
HO398_RS06355	COG4608	Belongs to the ABC transporter superfamily
HO398_RS06375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HO398_RS06380	COG2350	Protein conserved in bacteria
HO398_RS06385	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HO398_RS06390	COG1607	acyl-coa hydrolase
HO398_RS06410	COG3047	cAMP biosynthetic process
HO398_RS06415	COG3685	Protein conserved in bacteria
HO398_RS06420	COG3685	Protein conserved in bacteria
HO398_RS06425	COG3729	General stress protein
HO398_RS06440	COG0134	indole-3-glycerol-phosphate synthase activity
HO398_RS06440	COG0135	phosphoribosylanthranilate isomerase activity
HO398_RS06445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HO398_RS06445	COG0512	Glutamine amidotransferase of anthranilate synthase
HO398_RS06450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HO398_RS06460	COG0613	PHP domain protein
HO398_RS06465	COG0009	L-threonylcarbamoyladenylate synthase
HO398_RS06485	COG1187	pseudouridine synthase activity
HO398_RS06490	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HO398_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS06500	COG0616	signal peptide processing
HO398_RS06510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HO398_RS06515	COG0583	DNA-binding transcription factor activity
HO398_RS06535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HO398_RS06545	COG0671	phosphoesterase, PA-phosphatase related
HO398_RS06550	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HO398_RS06555	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HO398_RS06565	COG0023	Translation Initiation Factor
HO398_RS06575	COG1349	DNA-binding transcription factor activity
HO398_RS06585	COG5001	Diguanylate cyclase
HO398_RS06600	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HO398_RS06600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HO398_RS06605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HO398_RS06610	COG2852	Protein conserved in bacteria
HO398_RS06615	COG4172	Belongs to the ABC transporter superfamily
HO398_RS06620	COG4172	Belongs to the ABC transporter superfamily
HO398_RS06625	COG4171	peptide transport system, permease
HO398_RS06630	COG4168	peptide transport system, permease
HO398_RS06635	COG4166	transmembrane transport
HO398_RS06645	COG0531	amino acid
HO398_RS06655	COG0174	glutamine synthetase
HO398_RS06660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HO398_RS06665	COG1917	Cupin 2, conserved barrel domain protein
HO398_RS06665	COG1396	sequence-specific DNA binding
HO398_RS06670	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HO398_RS06680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HO398_RS06685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HO398_RS06690	COG1842	Phage shock protein A
HO398_RS06700	COG1983	PspC domain protein
HO398_RS06710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HO398_RS06715	COG0366	Alpha amylase catalytic
HO398_RS06720	COG1653	transport
HO398_RS06725	COG1175	transmembrane transport
HO398_RS06730	COG0395	ABC-type sugar transport system, permease component
HO398_RS06735	COG1063	alcohol dehydrogenase
HO398_RS06740	COG1082	Xylose isomerase domain protein TIM barrel
HO398_RS06745	COG0673	inositol 2-dehydrogenase activity
HO398_RS06750	COG1554	hydrolase, family 65, central catalytic
HO398_RS06755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HO398_RS06760	COG3842	ATPase activity
HO398_RS06770	COG1609	Transcriptional regulator
HO398_RS06775	COG3106	COG3106 Predicted ATPase
HO398_RS06785	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HO398_RS06790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HO398_RS06795	COG4948	Mandelate Racemase Muconate Lactonizing
HO398_RS06800	COG2866	Carboxypeptidase
HO398_RS06815	COG1073	alpha beta
HO398_RS06820	COG0583	DNA-binding transcription factor activity
HO398_RS06825	COG4166	transmembrane transport
HO398_RS06830	COG0668	transmembrane transport
HO398_RS06835	COG3182	Iron-regulated membrane protein
HO398_RS06840	COG0589	response to stress
HO398_RS06850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HO398_RS06855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HO398_RS06860	COG1473	amidohydrolase
HO398_RS06865	COG1473	amidohydrolase
HO398_RS06870	COG0583	DNA-binding transcription factor activity
HO398_RS06875	COG2840	Smr protein MutS2
HO398_RS06880	COG3706	GGDEF domain
HO398_RS06890	COG0513	Belongs to the DEAD box helicase family
HO398_RS06900	COG0582	viral genome integration into host DNA
HO398_RS06920	COG3723	Recombinational DNA repair protein, rece pathway
HO398_RS06970	COG3772	lysozyme
HO398_RS06980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HO398_RS06985	COG1475	DNA binding
HO398_RS07010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HO398_RS07030	COG0589	response to stress
HO398_RS07035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HO398_RS07040	COG0674	pyruvate-flavodoxin oxidoreductase activity
HO398_RS07040	COG1013	pyruvate-flavodoxin oxidoreductase activity
HO398_RS07040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HO398_RS07040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HO398_RS07045	COG3042	response to heat
HO398_RS07050	COG3187	Heat shock protein
HO398_RS07055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HO398_RS07060	COG2911	Protein conserved in bacteria
HO398_RS07070	COG3784	Protein of unknown function (DUF1318)
HO398_RS07075	COG2207	Transcriptional regulator
HO398_RS07080	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS07105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HO398_RS07110	COG4589	Belongs to the CDS family
HO398_RS07115	COG2267	carboxylic ester hydrolase activity
HO398_RS07120	COG0671	phosphoesterase, PA-phosphatase related
HO398_RS07120	COG2453	phosphatase
HO398_RS07130	COG1643	Atp-dependent helicase
HO398_RS07135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HO398_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS07145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HO398_RS07155	COG3038	cytochrome b561
HO398_RS07170	COG0840	transmembrane signaling receptor activity
HO398_RS07175	COG0583	DNA-binding transcription factor activity
HO398_RS07180	COG5383	Protein conserved in bacteria
HO398_RS07190	COG2841	Protein conserved in bacteria
HO398_RS07195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HO398_RS07200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HO398_RS07205	COG1275	C4-dicarboxylate transporter malic acid transport protein
HO398_RS07210	COG0500	methyltransferase
HO398_RS07225	COG0675	Transposase, IS605 OrfB family
HO398_RS07230	COG3135	benzoate transporter
HO398_RS07235	COG1396	sequence-specific DNA binding
HO398_RS07240	COG0826	peptidase U32
HO398_RS07250	COG1724	mRNA binding
HO398_RS07255	COG1598	PFAM Uncharacterised protein family UPF0150
HO398_RS07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HO398_RS07265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HO398_RS07270	COG3842	ATPase activity
HO398_RS07275	COG1176	ABC-type spermidine putrescine transport system, permease component I
HO398_RS07280	COG1177	transmembrane transport
HO398_RS07305	COG3238	Protein conserved in bacteria
HO398_RS07310	COG1247	-acetyltransferase
HO398_RS07315	COG2130	NADP-dependent
HO398_RS07320	COG1802	Transcriptional regulator
HO398_RS07325	COG4772	TonB-dependent receptor
HO398_RS07330	COG3391	amine dehydrogenase activity
HO398_RS07335	COG1113	amino acid transport
HO398_RS07340	COG0625	glutathione transferase activity
HO398_RS07385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HO398_RS07390	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HO398_RS07400	COG2181	nitrate reductase activity
HO398_RS07405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HO398_RS07410	COG1140	nitrate reductase beta subunit
HO398_RS07415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HO398_RS07420	COG2223	nitrite transmembrane transporter activity
HO398_RS07430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HO398_RS07435	COG0697	spore germination
HO398_RS07445	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS07450	COG2864	formate dehydrogenase
HO398_RS07455	COG3093	addiction module antidote protein HigA
HO398_RS07460	COG1064	alcohol dehydrogenase
HO398_RS07480	COG1764	response to oxidative stress
HO398_RS07485	COG4608	Belongs to the ABC transporter superfamily
HO398_RS07490	COG0444	Belongs to the ABC transporter superfamily
HO398_RS07495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO398_RS07500	COG0601	transmembrane transport
HO398_RS07505	COG0747	negative chemotaxis
HO398_RS07510	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HO398_RS07515	COG2199	diguanylate cyclase activity
HO398_RS07515	COG2200	EAL domain
HO398_RS07515	COG2202	Pas domain
HO398_RS07530	COG0531	amino acid
HO398_RS07535	COG0076	glutamate decarboxylase activity
HO398_RS07540	COG0612	Peptidase, M16
HO398_RS07545	COG4771	TonB-dependent receptor
HO398_RS07550	COG4178	(ABC) transporter
HO398_RS07560	COG0641	radical SAM
HO398_RS07565	COG3119	arylsulfatase activity
HO398_RS07570	COG2207	Transcriptional regulator
HO398_RS07580	COG0243	molybdopterin cofactor binding
HO398_RS07585	COG3539	Fimbrial protein
HO398_RS07590	COG3539	Fimbrial protein
HO398_RS07595	COG3539	Fimbrial protein
HO398_RS07600	COG3188	usher protein
HO398_RS07605	COG3188	usher protein
HO398_RS07610	COG3188	usher protein
HO398_RS07620	COG3539	Fimbrial protein
HO398_RS07625	COG3550	peptidyl-serine autophosphorylation
HO398_RS07630	COG1396	sequence-specific DNA binding
HO398_RS07665	COG3781	membrane
HO398_RS07675	COG2199	diguanylate cyclase activity
HO398_RS07685	COG2066	Belongs to the glutaminase family
HO398_RS07690	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS07695	COG0583	DNA-binding transcription factor activity
HO398_RS07725	COG1846	Transcriptional regulator
HO398_RS07730	COG4977	sequence-specific DNA binding
HO398_RS07740	COG0697	spore germination
HO398_RS07745	COG2814	Major facilitator Superfamily
HO398_RS07755	COG3706	GGDEF domain
HO398_RS07760	COG3111	PFAM Bacterial OB fold (BOF) protein
HO398_RS07765	COG1546	Belongs to the CinA family
HO398_RS07770	COG0339	signal peptide processing
HO398_RS07775	COG4221	oxidoreductase activity
HO398_RS07780	COG1802	Transcriptional regulator
HO398_RS07790	COG0246	Mannitol dehydrogenase
HO398_RS07795	COG0477	Major facilitator Superfamily
HO398_RS07810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HO398_RS07870	COG1403	HNH endonuclease
HO398_RS07870	COG1403	HNH endonuclease
HO398_RS07900	COG1846	Transcriptional regulator
HO398_RS07915	COG1396	sequence-specific DNA binding
HO398_RS07965	COG1063	alcohol dehydrogenase
HO398_RS07970	COG4948	Mandelate Racemase Muconate Lactonizing
HO398_RS07985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HO398_RS08000	COG0243	molybdopterin cofactor binding
HO398_RS08005	COG0243	molybdopterin cofactor binding
HO398_RS08010	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS08015	COG3302	dmso reductase anchor subunit
HO398_RS08020	COG3381	protein complex oligomerization
HO398_RS08030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HO398_RS08035	COG1940	carbohydrate kinase activity
HO398_RS08040	COG0583	DNA-binding transcription factor activity
HO398_RS08045	COG2814	Major facilitator Superfamily
HO398_RS08060	COG3591	Belongs to the peptidase S1B family
HO398_RS08075	COG0628	permease
HO398_RS08080	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HO398_RS08085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HO398_RS08095	COG0531	amino acid
HO398_RS08105	COG3136	membrane protein required for alginate biosynthesis
HO398_RS08110	COG0745	RESPONSE REGULATOR receiver
HO398_RS08115	COG2205	protein histidine kinase activity
HO398_RS08125	COG0114	fumarate hydratase activity
HO398_RS08130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HO398_RS08130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HO398_RS08135	COG1482	cell wall glycoprotein biosynthetic process
HO398_RS08140	COG5339	Protein conserved in bacteria
HO398_RS08155	COG3250	beta-galactosidase activity
HO398_RS08160	COG1309	transcriptional regulator
HO398_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS08170	COG1609	Transcriptional regulator
HO398_RS08175	COG1263	PTS System
HO398_RS08175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS08180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HO398_RS08190	COG0673	inositol 2-dehydrogenase activity
HO398_RS08230	COG4659	FMN binding
HO398_RS08240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HO398_RS08245	COG3104	oligopeptide transport
HO398_RS08250	COG0625	glutathione transferase activity
HO398_RS08255	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HO398_RS08270	COG3895	Periplasmic Protein
HO398_RS08280	COG3133	Outer membrane lipoprotein
HO398_RS08295	COG1566	PFAM secretion protein HlyD family protein
HO398_RS08300	COG1289	transmembrane transporter activity
HO398_RS08305	COG2032	superoxide dismutase activity
HO398_RS08310	COG4989	oxidoreductase activity
HO398_RS08315	COG3313	Fe-S protein
HO398_RS08320	COG1309	transcriptional regulator
HO398_RS08325	COG1902	pentaerythritol trinitrate reductase activity
HO398_RS08330	COG0346	lactoylglutathione lyase activity
HO398_RS08340	COG1201	RNA secondary structure unwinding
HO398_RS08345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HO398_RS08355	COG0791	NLP P60 protein
HO398_RS08360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HO398_RS08365	COG2814	Major facilitator Superfamily
HO398_RS08380	COG0583	DNA-binding transcription factor activity
HO398_RS08385	COG2814	Major facilitator Superfamily
HO398_RS08390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HO398_RS08395	COG0307	riboflavin synthase, alpha
HO398_RS08405	COG3468	outer membrane autotransporter barrel domain protein
HO398_RS08425	COG4529	Protein conserved in bacteria
HO398_RS08435	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HO398_RS08440	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS08450	COG2414	aldehyde ferredoxin oxidoreductase
HO398_RS08455	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS08465	COG0469	pyruvate kinase activity
HO398_RS08470	COG4238	major outer membrane lipoprotein
HO398_RS08475	COG1376	ErfK ybiS ycfS ynhG family protein
HO398_RS08490	COG0719	Fe-S assembly protein
HO398_RS08495	COG0396	ATPase activity
HO398_RS08510	COG2050	protein possibly involved in aromatic compounds catabolism
HO398_RS08515	COG0277	FAD linked oxidase domain protein
HO398_RS08515	COG0247	lactate metabolic process
HO398_RS08520	COG0628	permease
HO398_RS08540	COG2271	Major facilitator Superfamily
HO398_RS08555	COG4670	ketone body catabolic process
HO398_RS08560	COG1960	acyl-CoA dehydrogenase activity
HO398_RS08565	COG1917	Cupin 2, conserved barrel domain protein
HO398_RS08565	COG2207	Transcriptional regulator
HO398_RS08570	COG2086	electron transfer activity
HO398_RS08575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HO398_RS08580	COG0644	oxidoreductase
HO398_RS08585	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HO398_RS08590	COG0318	PFAM AMP-dependent synthetase and ligase
HO398_RS08595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO398_RS08595	COG0574	Belongs to the PEP-utilizing enzyme family
HO398_RS08605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HO398_RS08610	COG4256	Hemin uptake protein
HO398_RS08625	COG0791	NLP P60 protein
HO398_RS08635	COG0386	Belongs to the glutathione peroxidase family
HO398_RS08650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HO398_RS08650	COG0072	phenylalanine-tRNA ligase activity
HO398_RS08695	COG3137	Salt-induced outer membrane protein
HO398_RS08700	COG1105	Belongs to the carbohydrate kinase PfkB family
HO398_RS08710	COG3001	Fructosamine kinase
HO398_RS08720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HO398_RS08725	COG1988	membrane-bound metal-dependent
HO398_RS08745	COG0753	catalase activity
HO398_RS08755	COG1486	melibiose metabolic process
HO398_RS08760	COG1917	Cupin 2, conserved barrel domain protein
HO398_RS08760	COG2169	Transcriptional regulator
HO398_RS08765	COG1447	Phosphotransferase system cellobiose-specific component IIA
HO398_RS08770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HO398_RS08775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HO398_RS08780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO398_RS08790	COG0322	excinuclease ABC activity
HO398_RS08800	COG3678	ATP-independent chaperone mediated protein folding
HO398_RS08830	COG0708	Exodeoxyribonuclease III
HO398_RS08835	COG0398	Pfam SNARE associated Golgi protein
HO398_RS08845	COG0398	Pfam SNARE associated Golgi protein
HO398_RS08850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HO398_RS08855	COG4134	Bacterial extracellular solute-binding protein
HO398_RS08860	COG4135	transport system, permease component
HO398_RS08865	COG4136	ATPase activity
HO398_RS08870	COG2897	thiosulfate sulfurtransferase activity
HO398_RS08875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HO398_RS08880	COG0494	nUDIX hydrolase
HO398_RS08890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HO398_RS08900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HO398_RS08910	COG0778	Nitroreductase
HO398_RS08915	COG0616	signal peptide processing
HO398_RS08920	COG0252	asparaginase activity
HO398_RS08925	COG1335	isochorismatase
HO398_RS08930	COG2814	Major facilitator Superfamily
HO398_RS08935	COG1349	DNA-binding transcription factor activity
HO398_RS08940	COG0667	Aldo Keto reductase
HO398_RS08945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS08950	COG0191	fructose-bisphosphate aldolase activity
HO398_RS08955	COG1063	alcohol dehydrogenase
HO398_RS08960	COG2271	Major facilitator Superfamily
HO398_RS08965	COG1063	alcohol dehydrogenase
HO398_RS08970	COG3139	Protein of unknown function (DUF1315)
HO398_RS08980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HO398_RS08985	COG0676	glucose-6-phosphate 1-epimerase activity
HO398_RS08990	COG0656	L-ascorbic acid biosynthetic process
HO398_RS08995	COG3713	MltA-interacting MipA family protein
HO398_RS09010	COG2199	diguanylate cyclase activity
HO398_RS09015	COG2199	diguanylate cyclase activity
HO398_RS09020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HO398_RS09035	COG2207	Transcriptional regulator
HO398_RS09040	COG2807	transmembrane transport
HO398_RS09045	COG3189	MarR family transcriptional regulator
HO398_RS09050	COG3042	response to heat
HO398_RS09055	COG2199	diguanylate cyclase activity
HO398_RS09055	COG2203	Gaf domain
HO398_RS09070	COG2261	transglycosylase associated protein
HO398_RS09085	COG3385	transposase activity
HO398_RS09090	COG3615	Tellurite resistance protein tehB
HO398_RS09100	COG0583	DNA-binding transcription factor activity
HO398_RS09105	COG0473	3-isopropylmalate dehydrogenase activity
HO398_RS09115	COG4638	Rieske (2fe-2S)
HO398_RS09120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HO398_RS09125	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HO398_RS09130	COG0318	PFAM AMP-dependent synthetase and ligase
HO398_RS09135	COG3065	identical protein binding
HO398_RS09140	COG1214	PFAM Peptidase M22, glycoprotease
HO398_RS09145	COG1199	ATP-dependent helicase activity
HO398_RS09150	COG0251	oxidation-reduction process
HO398_RS09165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HO398_RS09175	COG1760	l-serine dehydratase
HO398_RS09180	COG2200	EAL domain
HO398_RS09185	COG1253	flavin adenine dinucleotide binding
HO398_RS09190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS09190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS09195	COG3715	PTS system
HO398_RS09200	COG3716	PTS system mannose fructose sorbose family IID component
HO398_RS09215	COG2226	methyltransferase
HO398_RS09245	COG1414	Transcriptional regulator
HO398_RS09250	COG2814	Major facilitator Superfamily
HO398_RS09260	COG0793	Belongs to the peptidase S41A family
HO398_RS09270	COG1956	GAF domain-containing protein
HO398_RS09275	COG2995	paraquat-inducible protein a
HO398_RS09280	COG3008	intermembrane lipid transfer
HO398_RS09300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HO398_RS09310	COG1276	copper resistance
HO398_RS09315	COG2372	response to copper ion
HO398_RS09325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HO398_RS09330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HO398_RS09335	COG1770	oligopeptidase
HO398_RS09340	COG2979	Protein of unknown function (DUF533)
HO398_RS09350	COG3141	response to X-ray
HO398_RS09360	COG0800	Aldolase
HO398_RS09365	COG0129	dihydroxy-acid dehydratase activity
HO398_RS09370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HO398_RS09375	COG1737	Transcriptional regulator
HO398_RS09380	COG0469	pyruvate kinase activity
HO398_RS09385	COG1560	Kdo2-lipid A biosynthetic process
HO398_RS09390	COG0739	heme binding
HO398_RS09395	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HO398_RS09405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HO398_RS09435	COG0217	transcriptional regulatory protein
HO398_RS09440	COG0494	nUDIX hydrolase
HO398_RS09450	COG1335	isochorismatase
HO398_RS09455	COG1801	Protein of unknown function DUF72
HO398_RS09460	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HO398_RS09475	COG0243	molybdopterin cofactor binding
HO398_RS09480	COG3005	denitrification pathway
HO398_RS09490	COG3102	Protein conserved in bacteria
HO398_RS09500	COG3755	Protein conserved in bacteria
HO398_RS09510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HO398_RS09515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HO398_RS09520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HO398_RS09525	COG0745	RESPONSE REGULATOR receiver
HO398_RS09535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HO398_RS09540	COG0840	transmembrane signaling receptor activity
HO398_RS09545	COG0840	transmembrane signaling receptor activity
HO398_RS09550	COG0835	chemotaxis
HO398_RS09555	COG2198	Histidine kinase
HO398_RS09555	COG0643	Histidine kinase
HO398_RS09560	COG1360	Flagellar Motor Protein
HO398_RS09565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HO398_RS09580	COG0589	response to stress
HO398_RS09590	COG1877	trehalose-phosphatase activity
HO398_RS09595	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS09600	COG1129	ABC transporter
HO398_RS09605	COG1879	ABC-type sugar transport system periplasmic component
HO398_RS09610	COG1528	Iron-storage protein
HO398_RS09630	COG1528	Iron-storage protein
HO398_RS09640	COG0814	amino acid
HO398_RS09645	COG3012	SEC-C Motif Domain Protein
HO398_RS09645	COG3318	Belongs to the UPF0149 family
HO398_RS09690	COG2205	protein histidine kinase activity
HO398_RS09695	COG0745	RESPONSE REGULATOR receiver
HO398_RS09700	COG2351	hydroxyisourate hydrolase activity
HO398_RS09715	COG3443	Belongs to the bacterial solute-binding protein 9 family
HO398_RS09720	COG3038	cytochrome b561
HO398_RS09740	COG1470	cell adhesion involved in biofilm formation
HO398_RS09740	COG1388	LysM domain
HO398_RS09750	COG0477	Major facilitator Superfamily
HO398_RS09755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HO398_RS09760	COG0217	transcriptional regulatory protein
HO398_RS09770	COG0534	Mate efflux family protein
HO398_RS09780	COG0583	DNA-binding transcription factor activity
HO398_RS09785	COG0583	DNA-binding transcription factor activity
HO398_RS09795	COG1376	ErfK ybiS ycfS ynhG family protein
HO398_RS09810	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HO398_RS09860	COG1289	transmembrane transporter activity
HO398_RS09870	COG1686	Belongs to the peptidase S11 family
HO398_RS09875	COG2925	Exonuclease
HO398_RS09880	COG0425	Belongs to the sulfur carrier protein TusA family
HO398_RS09885	COG2391	methyltransferase activity
HO398_RS09890	COG0531	amino acid
HO398_RS09900	COG0583	DNA-binding transcription factor activity
HO398_RS09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HO398_RS09920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HO398_RS09930	COG0131	Imidazoleglycerol-phosphate dehydratase
HO398_RS09930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HO398_RS09935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HO398_RS09950	COG0140	phosphoribosyl-ATP diphosphatase activity
HO398_RS09950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HO398_RS09955	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HO398_RS09960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HO398_RS09965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HO398_RS09970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HO398_RS10020	COG2244	polysaccharide biosynthetic process
HO398_RS10030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HO398_RS10040	COG1088	dTDP-glucose 4,6-dehydratase activity
HO398_RS10045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HO398_RS10055	COG0438	transferase activity, transferring glycosyl groups
HO398_RS10060	COG2327	Polysaccharide pyruvyl transferase
HO398_RS10065	COG2244	polysaccharide biosynthetic process
HO398_RS10070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HO398_RS10075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HO398_RS10080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HO398_RS10080	COG0662	Cupin 2, conserved barrel domain protein
HO398_RS10085	COG0297	glycogen (starch) synthase activity
HO398_RS10090	COG1051	belongs to the nudix hydrolase family
HO398_RS10095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HO398_RS10100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HO398_RS10105	COG0110	maltose O-acetyltransferase activity
HO398_RS10110	COG1216	Glycosyl transferase, family 2
HO398_RS10120	COG0438	transferase activity, transferring glycosyl groups
HO398_RS10125	COG1045	serine acetyltransferase
HO398_RS10130	COG0463	Glycosyl transferase, family 2
HO398_RS10135	COG3206	protein involved in exopolysaccharide biosynthesis
HO398_RS10135	COG0489	protein tyrosine kinase activity
HO398_RS10140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HO398_RS10145	COG1596	polysaccharide export
HO398_RS10150	COG1253	flavin adenine dinucleotide binding
HO398_RS10155	COG2982	Protein involved in outer membrane biogenesis
HO398_RS10165	COG0572	uridine kinase
HO398_RS10170	COG5002	protein histidine kinase activity
HO398_RS10170	COG5001	Diguanylate cyclase
HO398_RS10170	COG3447	MASE1 domain protein
HO398_RS10175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HO398_RS10180	COG0443	Heat shock 70 kDa protein
HO398_RS10185	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HO398_RS10190	COG0631	protein serine/threonine phosphatase activity
HO398_RS10195	COG4245	von Willebrand factor, type A
HO398_RS10240	COG2205	protein histidine kinase activity
HO398_RS10245	COG0745	RESPONSE REGULATOR receiver
HO398_RS10285	COG1063	alcohol dehydrogenase
HO398_RS10290	COG3775	system Galactitol-specific IIC component
HO398_RS10295	COG3414	Phosphotransferase system galactitol-specific IIB component
HO398_RS10300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS10315	COG1830	Aldolase
HO398_RS10320	COG2211	Major facilitator Superfamily
HO398_RS10325	COG1397	ADP-ribosylglycohydrolase
HO398_RS10330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS10335	COG2188	Transcriptional regulator
HO398_RS10340	COG3757	hydrolase, family 25
HO398_RS10345	COG0351	phosphomethylpyrimidine kinase
HO398_RS10395	COG0489	protein tyrosine kinase activity
HO398_RS10405	COG3831	ATPase activity
HO398_RS10410	COG3831	ATPase activity
HO398_RS10420	COG0714	Associated with various cellular activities
HO398_RS10425	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HO398_RS10430	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HO398_RS10435	COG4715	Zinc finger, swim domain protein
HO398_RS10440	COG4808	Protein conserved in bacteria
HO398_RS10445	COG4807	Protein conserved in bacteria
HO398_RS10450	COG3279	Response regulator of the LytR AlgR family
HO398_RS10455	COG3275	phosphorelay sensor kinase activity
HO398_RS10460	COG0789	Transcriptional regulator
HO398_RS10470	COG1174	glycine betaine transport
HO398_RS10475	COG1125	glycine betaine transport
HO398_RS10480	COG1174	glycine betaine transport
HO398_RS10485	COG1732	Glycine betaine
HO398_RS10490	COG1472	Belongs to the glycosyl hydrolase 3 family
HO398_RS10495	COG0277	FAD linked oxidase domain protein
HO398_RS10500	COG1686	Belongs to the peptidase S11 family
HO398_RS10510	COG0586	Pfam SNARE associated Golgi protein
HO398_RS10515	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS10530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HO398_RS10540	COG1346	cytolysis
HO398_RS10550	COG2949	membrane
HO398_RS10560	COG0493	'glutamate synthase
HO398_RS10565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HO398_RS10565	COG0167	dihydroorotate dehydrogenase activity
HO398_RS10570	COG4211	Belongs to the binding-protein-dependent transport system permease family
HO398_RS10575	COG1129	ABC transporter
HO398_RS10585	COG1609	Transcriptional regulator
HO398_RS10590	COG2311	Membrane
HO398_RS10605	COG4771	TonB-dependent receptor
HO398_RS10610	COG0833	amino acid
HO398_RS10615	COG0583	DNA-binding transcription factor activity
HO398_RS10620	COG2855	membrane
HO398_RS10630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS10630	COG1522	sequence-specific DNA binding
HO398_RS10635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HO398_RS10645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HO398_RS10650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HO398_RS10655	COG2313	pseudouridylate synthase activity
HO398_RS10660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS10665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HO398_RS10665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS10665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS10670	COG1105	Belongs to the carbohydrate kinase PfkB family
HO398_RS10675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS10675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS10680	COG2814	Major facilitator Superfamily
HO398_RS10695	COG0246	Mannitol dehydrogenase
HO398_RS10700	COG0523	cobalamin synthesis protein
HO398_RS10705	COG0671	phosphoesterase, PA-phosphatase related
HO398_RS10710	COG0791	NLP P60 protein
HO398_RS10715	COG2200	EAL domain
HO398_RS10720	COG4166	transmembrane transport
HO398_RS10725	COG4174	ABC transporter (Permease)
HO398_RS10730	COG4239	(ABC) transporter, permease
HO398_RS10735	COG4172	Belongs to the ABC transporter superfamily
HO398_RS10745	COG2814	Major facilitator Superfamily
HO398_RS10750	COG1187	pseudouridine synthase activity
HO398_RS10755	COG1061	Type III restriction enzyme res subunit
HO398_RS10775	COG3083	sulfuric ester hydrolase activity
HO398_RS10785	COG3468	outer membrane autotransporter barrel domain protein
HO398_RS10790	COG2197	response regulator
HO398_RS10795	COG3088	subunit of a heme lyase
HO398_RS10795	COG4235	cytochrome complex assembly
HO398_RS10800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HO398_RS10805	COG1138	Cytochrome C-type biogenesis protein
HO398_RS10815	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HO398_RS10820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HO398_RS10825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HO398_RS10830	COG4133	protoheme IX ABC transporter activity
HO398_RS10835	COG3005	denitrification pathway
HO398_RS10840	COG3043	anaerobic respiration
HO398_RS10845	COG0348	domain, Protein
HO398_RS10850	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS10860	COG3062	negative regulation of establishment of protein localization
HO398_RS10865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS10865	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS10880	COG4615	Cyclic peptide transporter
HO398_RS10885	COG3145	DNA-N1-methyladenine dioxygenase activity
HO398_RS10890	COG2169	Transcriptional regulator
HO398_RS10890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HO398_RS10895	COG1477	protein flavinylation
HO398_RS10900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HO398_RS10910	COG0784	Response regulator, receiver
HO398_RS10910	COG2205	protein histidine kinase activity
HO398_RS10915	COG3852	Histidine kinase
HO398_RS10920	COG2204	response regulator
HO398_RS10925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HO398_RS10930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HO398_RS10935	COG2031	fatty acid transporter
HO398_RS10940	COG0183	Belongs to the thiolase family
HO398_RS10945	COG4676	Protein conserved in bacteria
HO398_RS10950	COG5445	Predicted secreted protein (DUF2300)
HO398_RS10955	COG2373	Large extracellular alpha-helical protein
HO398_RS10960	COG3234	Protein of unknown function (DUF1175)
HO398_RS10965	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HO398_RS10970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HO398_RS10980	COG3468	outer membrane autotransporter barrel domain protein
HO398_RS10985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HO398_RS10990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HO398_RS10995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HO398_RS11000	COG3642	lipopolysaccharide core region biosynthetic process
HO398_RS11010	COG0584	glycerophosphoryl diester phosphodiesterase
HO398_RS11015	COG2271	Major facilitator Superfamily
HO398_RS11020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HO398_RS11030	COG0247	lactate metabolic process
HO398_RS11035	COG5464	transposase or invertase
HO398_RS11045	COG2271	Major facilitator Superfamily
HO398_RS11055	COG1414	Transcriptional regulator
HO398_RS11120	COG0318	PFAM AMP-dependent synthetase and ligase
HO398_RS11130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HO398_RS11145	COG1169	isochorismate synthase
HO398_RS11150	COG4575	ribosome binding
HO398_RS11155	COG2153	protein acetylation
HO398_RS11165	COG5160	protein modification by small protein removal
HO398_RS11190	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HO398_RS11195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HO398_RS11205	COG0839	Belongs to the complex I subunit 6 family
HO398_RS11220	COG1034	ATP synthesis coupled electron transport
HO398_RS11225	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HO398_RS11230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HO398_RS11250	COG0583	DNA-binding transcription factor activity
HO398_RS11255	COG0436	Aminotransferase
HO398_RS11265	COG0471	metal ion transport
HO398_RS11265	COG0490	domain, Protein
HO398_RS11270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HO398_RS11285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HO398_RS11290	COG0280	phosphate acetyltransferase
HO398_RS11290	COG0857	belongs to the CobB CobQ family
HO398_RS11295	COG1288	antiporter activity
HO398_RS11300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HO398_RS11305	COG0622	Phosphoesterase
HO398_RS11310	COG0625	glutathione transferase activity
HO398_RS11315	COG0625	glutathione transferase activity
HO398_RS11320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HO398_RS11325	COG1090	epimerase
HO398_RS11330	COG5464	transposase or invertase
HO398_RS11335	COG4598	ABC transporter
HO398_RS11340	COG4160	amino acid transport
HO398_RS11345	COG4215	(ABC) transporter
HO398_RS11350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS11355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS11360	COG0163	prenyltransferase activity
HO398_RS11365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HO398_RS11370	COG1286	toxin biosynthetic process
HO398_RS11375	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HO398_RS11380	COG0285	dihydrofolate synthase activity
HO398_RS11390	COG0586	Pfam SNARE associated Golgi protein
HO398_RS11400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HO398_RS11415	COG2814	Major facilitator Superfamily
HO398_RS11420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HO398_RS11435	COG3101	peptidyl-lysine hydroxylation
HO398_RS11440	COG0730	response to heat
HO398_RS11470	COG3539	Fimbrial protein
HO398_RS11475	COG3539	Fimbrial protein
HO398_RS11480	COG3539	Fimbrial protein
HO398_RS11485	COG3121	Chaperone
HO398_RS11490	COG3188	usher protein
HO398_RS11495	COG3539	Fimbrial protein
HO398_RS11500	COG2062	phosphohistidine phosphatase, SixA
HO398_RS11515	COG3691	Protein conserved in bacteria
HO398_RS11520	COG2067	long-chain fatty acid transport protein
HO398_RS11540	COG2853	Lipoprotein
HO398_RS11545	COG2116	formate transmembrane transporter activity
HO398_RS11555	COG0583	DNA-binding transcription factor activity
HO398_RS11560	COG2610	gluconate transmembrane transporter activity
HO398_RS11570	COG0477	Major facilitator Superfamily
HO398_RS11575	COG1566	PFAM secretion protein HlyD family protein
HO398_RS11580	COG2197	response regulator
HO398_RS11585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS11585	COG2198	Histidine kinase
HO398_RS11585	COG0784	Response regulator, receiver
HO398_RS11585	COG2205	protein histidine kinase activity
HO398_RS11590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HO398_RS11595	COG0679	Auxin Efflux Carrier
HO398_RS11600	COG0028	Belongs to the TPP enzyme family
HO398_RS11625	COG1560	Kdo2-lipid A biosynthetic process
HO398_RS11635	COG0436	Aminotransferase
HO398_RS11640	COG3275	phosphorelay sensor kinase activity
HO398_RS11645	COG3279	Response regulator of the LytR AlgR family
HO398_RS11650	COG2207	Transcriptional regulator
HO398_RS11655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS11655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO398_RS11655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS11660	COG1363	Peptidase, m42
HO398_RS11665	COG0006	proline dipeptidase activity
HO398_RS11670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS11675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS11700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HO398_RS11705	COG2199	diguanylate cyclase activity
HO398_RS11705	COG2200	EAL domain
HO398_RS11720	COG3415	Transposase
HO398_RS11725	COG3415	Transposase
HO398_RS11760	COG0583	DNA-binding transcription factor activity
HO398_RS11765	COG0385	Bile acid
HO398_RS11770	COG3530	Putative quorum-sensing-regulated virulence factor
HO398_RS11790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HO398_RS11795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS11800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO398_RS11805	COG2190	(PTS) system
HO398_RS11820	COG4884	unkown
HO398_RS11820	COG3831	ATPase activity
HO398_RS11825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HO398_RS11830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HO398_RS11835	COG4208	sulfate ABC transporter
HO398_RS11840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HO398_RS11845	COG4150	thiosulfate binding
HO398_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS11855	COG1737	Transcriptional regulator
HO398_RS11865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS11865	COG1263	PTS System
HO398_RS11870	COG2837	iron assimilation
HO398_RS11890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HO398_RS11900	COG2207	Transcriptional regulator
HO398_RS11905	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HO398_RS11910	COG4816	utilization protein
HO398_RS11920	COG4303	Ethanolamine ammonia lyase large subunit
HO398_RS11925	COG4819	ethanolamine utilization protein
HO398_RS11930	COG3192	ethanolamine utilization protein
HO398_RS11935	COG1454	alcohol dehydrogenase
HO398_RS11940	COG4820	ethanolamine utilization protein (EutJ)
HO398_RS11945	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS11950	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HO398_RS11955	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HO398_RS11960	COG0280	phosphate acetyltransferase
HO398_RS11965	COG4812	Cobalamin adenosyltransferase
HO398_RS11970	COG4766	ethanolamine catabolic process
HO398_RS11975	COG4917	ethanolamine utilization protein
HO398_RS11980	COG4810	utilization protein
HO398_RS11985	COG0280	phosphate acetyltransferase
HO398_RS11985	COG0281	malic enzyme
HO398_RS11990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HO398_RS11995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HO398_RS12000	COG5342	invasion associated locus B
HO398_RS12010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS12010	COG0493	'glutamate synthase
HO398_RS12015	COG3850	Histidine kinase
HO398_RS12020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HO398_RS12030	COG1393	Belongs to the ArsC family
HO398_RS12045	COG0400	carboxylic ester hydrolase activity
HO398_RS12050	COG1444	tRNA N-acetyltransferase activity
HO398_RS12055	COG2321	neutral zinc metallopeptidase
HO398_RS12065	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HO398_RS12075	COG2716	regulation of RNA biosynthetic process
HO398_RS12080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HO398_RS12085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS12090	COG0651	ATP synthesis coupled electron transport
HO398_RS12110	COG4237	Hydrogenase 4 membrane
HO398_RS12115	COG0651	ATP synthesis coupled electron transport
HO398_RS12120	COG3261	NADH dehydrogenase
HO398_RS12120	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HO398_RS12125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HO398_RS12130	COG3260	NADH ubiquinone oxidoreductase 20
HO398_RS12140	COG3604	Transcriptional regulator
HO398_RS12145	COG2116	formate transmembrane transporter activity
HO398_RS12150	COG0628	permease
HO398_RS12155	COG4783	chaperone-mediated protein folding
HO398_RS12160	COG1393	Belongs to the ArsC family
HO398_RS12170	COG2233	PERMEase
HO398_RS12185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HO398_RS12190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HO398_RS12195	COG0248	Ppx GppA phosphatase
HO398_RS12200	COG2200	EAL domain
HO398_RS12215	COG3133	Outer membrane lipoprotein
HO398_RS12230	COG0517	IMP dehydrogenase activity
HO398_RS12230	COG0516	GMP reductase activity
HO398_RS12240	COG1645	bacterial-type flagellum-dependent swarming motility
HO398_RS12255	COG2976	Protein conserved in bacteria
HO398_RS12285	COG4953	penicillin-binding protein 1C
HO398_RS12290	COG2373	Large extracellular alpha-helical protein
HO398_RS12295	COG2897	thiosulfate sulfurtransferase activity
HO398_RS12315	COG2975	iron-sulfur cluster assembly
HO398_RS12320	COG0633	Ferredoxin
HO398_RS12340	COG0822	iron-sulfur transferase activity
HO398_RS12360	COG0483	inositol monophosphate 1-phosphatase activity
HO398_RS12365	COG1073	alpha beta
HO398_RS12370	COG3711	transcriptional antiterminator
HO398_RS12375	COG2814	Major facilitator Superfamily
HO398_RS12380	COG0583	DNA-binding transcription factor activity
HO398_RS12385	COG4638	Rieske (2fe-2S)
HO398_RS12410	COG2259	Doxx family
HO398_RS12415	COG2017	converts alpha-aldose to the beta-anomer
HO398_RS12420	COG1063	alcohol dehydrogenase
HO398_RS12425	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS12430	COG1129	ABC transporter
HO398_RS12435	COG1879	ABC-type sugar transport system periplasmic component
HO398_RS12440	COG0457	Tetratricopeptide repeat
HO398_RS12445	COG1940	carbohydrate kinase activity
HO398_RS12455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HO398_RS12455	COG1017	nitric oxide dioxygenase activity
HO398_RS12460	COG0347	Belongs to the P(II) protein family
HO398_RS12465	COG2204	response regulator
HO398_RS12470	COG3170	Tfp pilus assembly protein FimV
HO398_RS12475	COG2205	protein histidine kinase activity
HO398_RS12500	COG0560	Phosphoserine phosphatase
HO398_RS12505	COG1737	Transcriptional regulator
HO398_RS12510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS12525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HO398_RS12545	COG0681	Belongs to the peptidase S26 family
HO398_RS12555	COG3086	response to oxidative stress
HO398_RS12560	COG3026	antisigma factor binding
HO398_RS12565	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HO398_RS12570	COG1595	DNA-templated transcription, initiation
HO398_RS12580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HO398_RS12590	COG0513	Belongs to the DEAD box helicase family
HO398_RS12595	COG0583	DNA-binding transcription factor activity
HO398_RS12615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HO398_RS12620	COG3118	belongs to the thioredoxin family
HO398_RS12630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HO398_RS12630	COG1042	CoA-binding domain protein
HO398_RS12630	COG0045	succinate-CoA ligase (ADP-forming) activity
HO398_RS12635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HO398_RS12640	COG5544	Lipoprotein
HO398_RS12645	COG0477	Major facilitator Superfamily
HO398_RS12670	COG0542	response to heat
HO398_RS12680	COG0564	pseudouridine synthase activity
HO398_RS12685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO398_RS12690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HO398_RS12700	COG0077	Prephenate dehydratase
HO398_RS12700	COG1605	Chorismate mutase
HO398_RS12705	COG1605	Chorismate mutase
HO398_RS12705	COG0287	Prephenate dehydrogenase
HO398_RS12710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HO398_RS12725	COG2199	diguanylate cyclase activity
HO398_RS12730	COG2885	chlorophyll binding
HO398_RS12755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HO398_RS12760	COG4137	Cytochrome C assembly protein
HO398_RS12765	COG4536	flavin adenine dinucleotide binding
HO398_RS12780	COG0497	DNA recombination
HO398_RS12785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO398_RS12795	COG2867	negative regulation of translational initiation
HO398_RS12810	COG0582	viral genome integration into host DNA
HO398_RS12820	COG1475	DNA binding
HO398_RS12840	COG0579	oxidoreductase
HO398_RS12845	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS12850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HO398_RS12855	COG1113	amino acid transport
HO398_RS12860	COG1802	Transcriptional regulator
HO398_RS12865	COG1652	LysM domain
HO398_RS12870	COG0401	homolog of Blt101
HO398_RS12875	COG0640	Transcriptional regulator
HO398_RS12880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HO398_RS12885	COG2916	Histone family protein nucleoid-structuring protein H-NS
HO398_RS12900	COG4575	ribosome binding
HO398_RS12905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HO398_RS12915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HO398_RS12920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HO398_RS12925	COG4175	Glycine betaine
HO398_RS12930	COG4176	ABC-type proline glycine betaine transport system permease component
HO398_RS12935	COG2113	Glycine betaine
HO398_RS12940	COG2814	Major facilitator Superfamily
HO398_RS12945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HO398_RS12955	COG1846	Transcriptional regulator
HO398_RS12960	COG1566	PFAM secretion protein HlyD family protein
HO398_RS12965	COG2814	Major facilitator Superfamily
HO398_RS12980	COG1238	metal cluster binding
HO398_RS12985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HO398_RS13015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HO398_RS13035	COG1546	Belongs to the CinA family
HO398_RS13040	COG2951	lytic endotransglycosylase activity
HO398_RS13045	COG3730	PTS system glucitol sorbitol-specific
HO398_RS13050	COG3732	PTS system glucitol sorbitol-specific
HO398_RS13060	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS13065	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS13070	COG1349	DNA-binding transcription factor activity
HO398_RS13075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HO398_RS13075	COG0517	IMP dehydrogenase activity
HO398_RS13095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HO398_RS13100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS13105	COG1609	Transcriptional regulator
HO398_RS13110	COG1263	PTS System
HO398_RS13110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS13115	COG2723	6-phospho-beta-galactosidase activity
HO398_RS13120	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HO398_RS13130	COG3260	NADH ubiquinone oxidoreductase 20
HO398_RS13135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HO398_RS13140	COG3261	NADH dehydrogenase
HO398_RS13140	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HO398_RS13145	COG0650	Formate hydrogenlyase subunit 4
HO398_RS13150	COG0651	ATP synthesis coupled electron transport
HO398_RS13155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS13165	COG0375	protein maturation
HO398_RS13170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HO398_RS13175	COG0298	carbon dioxide binding
HO398_RS13180	COG0409	Hydrogenase expression formation protein
HO398_RS13185	COG0309	Hydrogenase expression formation protein (HypE)
HO398_RS13190	COG3604	Transcriptional regulator
HO398_RS13210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HO398_RS13215	COG1349	DNA-binding transcription factor activity
HO398_RS13220	COG2084	Dehydrogenase
HO398_RS13225	COG3395	kinase activity
HO398_RS13230	COG0235	Class ii aldolase
HO398_RS13235	COG3622	Belongs to the hyi family
HO398_RS13240	COG2610	gluconate transmembrane transporter activity
HO398_RS13245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HO398_RS13250	COG4942	peptidase
HO398_RS13250	COG1388	LysM domain
HO398_RS13305	COG2234	aminopeptidase activity
HO398_RS13310	COG3385	transposase activity
HO398_RS13325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HO398_RS13335	COG0720	synthase
HO398_RS13340	COG0644	oxidoreductase
HO398_RS13345	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HO398_RS13350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HO398_RS13355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HO398_RS13360	COG2086	electron transfer activity
HO398_RS13365	COG0477	Major facilitator Superfamily
HO398_RS13370	COG0277	FAD linked oxidase domain protein
HO398_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS13380	COG2223	nitrite transmembrane transporter activity
HO398_RS13385	COG1070	Carbohydrate kinase
HO398_RS13390	COG0602	queuosine metabolic process
HO398_RS13400	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HO398_RS13415	COG3956	TIGRFAM MazG family protein
HO398_RS13420	COG2337	Toxic component of a toxin-antitoxin (TA) module
HO398_RS13425	COG2336	PFAM SpoVT AbrB
HO398_RS13430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HO398_RS13435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HO398_RS13440	COG3850	Histidine kinase
HO398_RS13440	COG3437	response regulator, receiver
HO398_RS13440	COG4999	Histidine kinase
HO398_RS13440	COG2205	protein histidine kinase activity
HO398_RS13445	COG4948	Mandelate Racemase Muconate Lactonizing
HO398_RS13450	COG4948	Mandelate Racemase Muconate Lactonizing
HO398_RS13455	COG2271	Major facilitator Superfamily
HO398_RS13460	COG0716	FMN binding
HO398_RS13465	COG0564	pseudouridine synthase activity
HO398_RS13470	COG3098	single-species biofilm formation
HO398_RS13485	COG1611	Belongs to the LOG family
HO398_RS13490	COG0814	amino acid
HO398_RS13495	COG1760	l-serine dehydratase
HO398_RS13505	COG1454	alcohol dehydrogenase
HO398_RS13530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HO398_RS13535	COG1609	Transcriptional regulator
HO398_RS13540	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS13545	COG1129	ABC transporter
HO398_RS13555	COG1070	Carbohydrate kinase
HO398_RS13565	COG1349	DNA-binding transcription factor activity
HO398_RS13575	COG2363	Small membrane protein
HO398_RS13580	COG0583	DNA-binding transcription factor activity
HO398_RS13590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HO398_RS13595	COG2166	iron-sulfur cluster assembly
HO398_RS13600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HO398_RS13605	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HO398_RS13625	COG0860	N-Acetylmuramoyl-L-alanine amidase
HO398_RS13630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HO398_RS13630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HO398_RS13635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HO398_RS13640	COG1074	ATP-dependent DNA helicase activity
HO398_RS13650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HO398_RS13655	COG4967	type IV pilus modification protein PilV
HO398_RS13665	COG4795	General secretion pathway protein
HO398_RS13670	COG2165	general secretion pathway protein
HO398_RS13685	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HO398_RS13700	COG0861	Integral membrane protein TerC family
HO398_RS13710	COG0667	Aldo Keto reductase
HO398_RS13725	COG1609	Transcriptional regulator
HO398_RS13735	COG0583	DNA-binding transcription factor activity
HO398_RS13740	COG1794	racemase activity, acting on amino acids and derivatives
HO398_RS13745	COG2814	Major facilitator Superfamily
HO398_RS13770	COG0183	Belongs to the thiolase family
HO398_RS13775	COG0814	amino acid
HO398_RS13780	COG2771	luxR family
HO398_RS13800	COG4942	peptidase
HO398_RS13805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HO398_RS13810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HO398_RS13815	COG2080	2 iron, 2 sulfur cluster binding
HO398_RS13825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HO398_RS13830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HO398_RS13835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HO398_RS13845	COG0549	Belongs to the carbamate kinase family
HO398_RS13850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HO398_RS13850	COG3608	succinylglutamate desuccinylase aspartoacylase
HO398_RS13855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HO398_RS13860	COG2068	MobA-Related Protein
HO398_RS13865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS13865	COG0493	'glutamate synthase
HO398_RS13870	COG0402	S-adenosylhomocysteine deaminase activity
HO398_RS13875	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HO398_RS13880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HO398_RS13880	COG2080	2 iron, 2 sulfur cluster binding
HO398_RS13885	COG2233	PERMEase
HO398_RS13890	COG0402	S-adenosylhomocysteine deaminase activity
HO398_RS13895	COG2252	PERMEase
HO398_RS13900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS13910	COG2233	PERMEase
HO398_RS13930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HO398_RS13940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HO398_RS13945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HO398_RS13950	COG4974	Belongs to the 'phage' integrase family
HO398_RS13955	COG0716	FMN binding
HO398_RS13965	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HO398_RS13975	COG1272	protein, Hemolysin III
HO398_RS13985	COG2723	6-phospho-beta-galactosidase activity
HO398_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS14015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HO398_RS14020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HO398_RS14025	COG0006	proline dipeptidase activity
HO398_RS14045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HO398_RS14055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HO398_RS14075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HO398_RS14075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HO398_RS14080	COG1703	isobutyryl-CoA mutase activity
HO398_RS14085	COG1024	Enoyl-CoA hydratase
HO398_RS14090	COG0427	acetyl-CoA hydrolase
HO398_RS14095	COG0583	DNA-binding transcription factor activity
HO398_RS14100	COG2968	Membrane
HO398_RS14105	COG1279	arginine transmembrane transporter activity
HO398_RS14110	COG0668	transmembrane transport
HO398_RS14115	COG0191	fructose-bisphosphate aldolase activity
HO398_RS14130	COG1072	(Pantothenic acid kinase))
HO398_RS14135	COG3722	fumarate hydratase activity
HO398_RS14140	COG1494	fructose-1,6-bisphosphatase
HO398_RS14145	COG1063	alcohol dehydrogenase
HO398_RS14150	COG2213	PTS system mannitol-specific
HO398_RS14155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS14160	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HO398_RS14165	COG0501	Belongs to the peptidase M48B family
HO398_RS14175	COG1166	arginine decarboxylase activity
HO398_RS14195	COG2814	Major facilitator Superfamily
HO398_RS14205	COG2356	endonuclease I
HO398_RS14210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HO398_RS14215	COG0189	ligase activity
HO398_RS14230	COG2805	Type II/IV secretion system protein
HO398_RS14235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HO398_RS14240	COG0762	integral membrane protein
HO398_RS14250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HO398_RS14255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HO398_RS14265	COG0252	asparaginase activity
HO398_RS14275	COG3171	Protein conserved in bacteria
HO398_RS14285	COG1194	a g-specific adenine glycosylase
HO398_RS14300	COG2211	Major facilitator Superfamily
HO398_RS14305	COG1982	Orn Lys Arg decarboxylase major
HO398_RS14310	COG1811	Na channel or pump
HO398_RS14415	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HO398_RS14430	COG4795	General secretion pathway protein
HO398_RS14445	COG2165	general secretion pathway protein
HO398_RS14450	COG1459	type II secretion system
HO398_RS14455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HO398_RS14475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HO398_RS14480	COG3064	Membrane
HO398_RS14485	COG1620	l-lactate permease
HO398_RS14490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HO398_RS14495	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HO398_RS14500	COG0247	lactate metabolic process
HO398_RS14505	COG0277	FAD linked oxidase domain protein
HO398_RS14510	COG0277	FAD linked oxidase domain protein
HO398_RS14515	COG2186	Transcriptional regulator
HO398_RS14520	COG0456	acetyltransferase
HO398_RS14525	COG0318	PFAM AMP-dependent synthetase and ligase
HO398_RS14535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HO398_RS14540	COG0156	8-amino-7-oxononanoate synthase activity
HO398_RS14550	COG0795	lipopolysaccharide-transporting ATPase activity
HO398_RS14555	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HO398_RS14565	COG2244	polysaccharide biosynthetic process
HO398_RS14570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HO398_RS14575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HO398_RS14580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HO398_RS14585	COG0306	phosphate transporter
HO398_RS14590	COG0754	glutathionylspermidine amidase activity
HO398_RS14595	COG0625	glutathione transferase activity
HO398_RS14600	COG0298	carbon dioxide binding
HO398_RS14605	COG0375	protein maturation
HO398_RS14610	COG1773	rubredoxin
HO398_RS14615	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HO398_RS14620	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HO398_RS14625	COG5557	Pfam Polysulphide reductase, NrfD
HO398_RS14630	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS14635	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HO398_RS14650	COG0667	Aldo Keto reductase
HO398_RS14660	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS14665	COG0848	biopolymer transport protein
HO398_RS14670	COG0811	peptide transport
HO398_RS14675	COG0626	cystathionine gamma-synthase activity
HO398_RS14680	COG0586	Pfam SNARE associated Golgi protein
HO398_RS14685	COG2207	Transcriptional regulator
HO398_RS14690	COG1979	alcohol dehydrogenase
HO398_RS14695	COG0656	L-ascorbic acid biosynthetic process
HO398_RS14705	COG4238	major outer membrane lipoprotein
HO398_RS14710	COG1032	radical SAM domain protein
HO398_RS14715	COG2132	Multicopper oxidase
HO398_RS14720	COG0204	Acyl-transferase
HO398_RS14725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HO398_RS14730	COG4166	transmembrane transport
HO398_RS14735	COG2944	sequence-specific DNA binding
HO398_RS14745	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HO398_RS14750	COG3111	PFAM Bacterial OB fold (BOF) protein
HO398_RS14755	COG0745	RESPONSE REGULATOR receiver
HO398_RS14760	COG0642	Histidine kinase
HO398_RS14770	COG2249	NAD(P)H dehydrogenase (quinone) activity
HO398_RS14775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HO398_RS14780	COG0187	DNA topoisomerase II activity
HO398_RS14785	COG3150	esterase
HO398_RS14790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HO398_RS14795	COG3151	Protein conserved in bacteria
HO398_RS14800	COG0494	nUDIX hydrolase
HO398_RS14805	COG1538	Outer membrane efflux protein
HO398_RS14815	COG0754	glutathionylspermidine amidase activity
HO398_RS14820	COG3384	dioxygenase
HO398_RS14840	COG2960	long-chain fatty acid transporting porin activity
HO398_RS14845	COG3539	Fimbrial protein
HO398_RS14850	COG3188	usher protein
HO398_RS14855	COG3121	Chaperone
HO398_RS14860	COG3539	Fimbrial protein
HO398_RS14870	COG1585	Membrane protein implicated in regulation of membrane protease activity
HO398_RS14875	COG2268	Band 7 protein
HO398_RS14900	COG3025	triphosphatase activity
HO398_RS14905	COG4991	sh3 domain protein
HO398_RS14920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HO398_RS14930	COG0583	DNA-binding transcription factor activity
HO398_RS14935	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HO398_RS14940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HO398_RS14945	COG0471	metal ion transport
HO398_RS14955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HO398_RS14960	COG0358	DNA primase activity
HO398_RS14965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HO398_RS14980	COG2375	cellular response to nickel ion
HO398_RS14985	COG1695	Transcriptional regulator
HO398_RS14990	COG0840	transmembrane signaling receptor activity
HO398_RS15000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HO398_RS15005	COG1609	Transcriptional regulator
HO398_RS15010	COG3250	beta-galactosidase activity
HO398_RS15015	COG2731	YhcH YjgK YiaL family protein
HO398_RS15020	COG0531	amino acid
HO398_RS15030	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HO398_RS15030	COG3408	Glycogen debranching enzyme
HO398_RS15035	COG1902	pentaerythritol trinitrate reductase activity
HO398_RS15035	COG0446	pyridine nucleotide-disulphide oxidoreductase
HO398_RS15040	COG5499	transcription regulator containing HTH domain
HO398_RS15045	COG4680	protein conserved in bacteria
HO398_RS15055	COG1451	nucleotide metabolic process
HO398_RS15060	COG2949	membrane
HO398_RS15065	COG0673	inositol 2-dehydrogenase activity
HO398_RS15070	COG0861	Integral membrane protein TerC family
HO398_RS15075	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HO398_RS15085	COG2721	sulfolactate sulfo-lyase activity
HO398_RS15095	COG2271	Major facilitator Superfamily
HO398_RS15100	COG2186	Transcriptional regulator
HO398_RS15105	COG0586	Pfam SNARE associated Golgi protein
HO398_RS15115	COG1422	Protein of unknown function (DUF1090)
HO398_RS15120	COG4575	ribosome binding
HO398_RS15125	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HO398_RS15135	COG2259	Doxx family
HO398_RS15140	COG0435	Glutathione S-transferase
HO398_RS15145	COG3152	Membrane
HO398_RS15150	COG3152	Membrane
HO398_RS15155	COG0583	DNA-binding transcription factor activity
HO398_RS15160	COG1741	Belongs to the pirin family
HO398_RS15175	COG0814	amino acid
HO398_RS15180	COG1760	l-serine dehydratase
HO398_RS15185	COG0251	oxidation-reduction process
HO398_RS15190	COG1882	Formate acetyltransferase
HO398_RS15195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HO398_RS15205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HO398_RS15210	COG0583	DNA-binding transcription factor activity
HO398_RS15235	COG1929	Belongs to the glycerate kinase type-1 family
HO398_RS15240	COG2084	Dehydrogenase
HO398_RS15250	COG2271	Major facilitator Superfamily
HO398_RS15255	COG2721	sulfolactate sulfo-lyase activity
HO398_RS15260	COG2002	toxin-antitoxin pair type II binding
HO398_RS15270	COG1349	DNA-binding transcription factor activity
HO398_RS15280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS15290	COG3716	PTS system mannose fructose sorbose family IID component
HO398_RS15295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS15300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HO398_RS15305	COG2222	sugar isomerase
HO398_RS15315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS15320	COG3715	PTS system
HO398_RS15325	COG3716	PTS system mannose fructose sorbose family IID component
HO398_RS15330	COG0363	glucosamine-6-phosphate deaminase activity
HO398_RS15335	COG3539	Fimbrial protein
HO398_RS15340	COG3121	Chaperone
HO398_RS15345	COG3188	usher protein
HO398_RS15350	COG3539	Fimbrial protein
HO398_RS15355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HO398_RS15360	COG3107	peptidoglycan biosynthetic process
HO398_RS15375	COG2823	Periplasmic or secreted lipoprotein
HO398_RS15380	COG0701	Predicted permease
HO398_RS15385	COG0702	epimerase
HO398_RS15390	COG0693	protein deglycase activity
HO398_RS15405	COG3153	acetyltransferase
HO398_RS15410	COG3154	lipid carrier protein
HO398_RS15415	COG0826	peptidase U32
HO398_RS15420	COG0826	peptidase U32
HO398_RS15425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HO398_RS15430	COG0814	amino acid
HO398_RS15435	COG0513	Belongs to the DEAD box helicase family
HO398_RS15475	COG0195	Participates in both transcription termination and antitermination
HO398_RS15495	COG2194	sulfuric ester hydrolase activity
HO398_RS15505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HO398_RS15515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HO398_RS15520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HO398_RS15530	COG1534	Rna-binding protein
HO398_RS15535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HO398_RS15540	COG2027	D-alanyl-D-alanine carboxypeptidase
HO398_RS15550	COG0697	spore germination
HO398_RS15565	COG0142	geranyltranstransferase activity
HO398_RS15570	COG3423	Transcriptional regulator
HO398_RS15580	COG5007	Belongs to the BolA IbaG family
HO398_RS15585	COG3113	response to antibiotic
HO398_RS15590	COG2854	intermembrane phospholipid transfer
HO398_RS15595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HO398_RS15600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HO398_RS15605	COG1127	ABC transporter
HO398_RS15610	COG0530	calcium, potassium:sodium antiporter activity
HO398_RS15615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HO398_RS15615	COG0517	IMP dehydrogenase activity
HO398_RS15620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HO398_RS15625	COG3117	lipopolysaccharide transmembrane transporter activity
HO398_RS15630	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HO398_RS15635	COG1137	ATPase activity
HO398_RS15640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HO398_RS15645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HO398_RS15660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS15665	COG0515	serine threonine protein kinase
HO398_RS15675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HO398_RS15680	COG2198	Histidine kinase
HO398_RS15680	COG5002	protein histidine kinase activity
HO398_RS15680	COG0784	Response regulator, receiver
HO398_RS15685	COG1242	4 iron, 4 sulfur cluster binding
HO398_RS15690	COG0070	glutamate synthase
HO398_RS15690	COG0069	glutamate synthase activity
HO398_RS15690	COG0067	glutamate synthase
HO398_RS15695	COG0493	'glutamate synthase
HO398_RS15700	COG4804	nuclease activity
HO398_RS15710	COG2731	YhcH YjgK YiaL family protein
HO398_RS15740	COG3069	C4-dicarboxylate transmembrane transporter activity
HO398_RS15745	COG2969	positive regulation of protein catabolic process
HO398_RS15750	COG0625	glutathione transferase activity
HO398_RS15765	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HO398_RS15770	COG3105	Protein conserved in bacteria
HO398_RS15775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HO398_RS15780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HO398_RS15800	COG2732	(Barnase) inhibitor
HO398_RS15820	COG0583	DNA-binding transcription factor activity
HO398_RS15825	COG0312	modulator of DNA gyrase
HO398_RS15830	COG3164	Protein of unknown function
HO398_RS15835	COG1530	ribonuclease E activity
HO398_RS15840	COG0424	maF-like protein
HO398_RS15845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HO398_RS15850	COG1792	Involved in formation and maintenance of cell shape
HO398_RS15855	COG1077	Cell shape determining protein MreB Mrl
HO398_RS15860	COG2200	EAL domain
HO398_RS15860	COG2199	diguanylate cyclase activity
HO398_RS15865	COG0604	alcohol dehydrogenase
HO398_RS15870	COG0511	ligase activity, forming carbon-carbon bonds
HO398_RS15875	COG0439	Biotin carboxylase
HO398_RS15880	COG3924	membrane
HO398_RS15885	COG4145	pantothenate transmembrane transporter activity
HO398_RS15895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HO398_RS15905	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HO398_RS15915	COG1309	transcriptional regulator
HO398_RS15920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS15925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HO398_RS15935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO398_RS15940	COG4597	amino acid ABC transporter
HO398_RS15945	COG0765	amino acid transport
HO398_RS15950	COG1126	abc transporter atp-binding protein
HO398_RS15995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HO398_RS16015	COG0551	DNA topoisomerase type I activity
HO398_RS16025	COG0758	DNA mediated transformation
HO398_RS16045	COG0569	domain protein
HO398_RS16055	COG3036	rescue of stalled ribosome
HO398_RS16060	COG0789	Transcriptional regulator
HO398_RS16100	COG0201	protein transport
HO398_RS16190	COG0089	rRNA binding
HO398_RS16215	COG3267	Type II secretory pathway component ExeA
HO398_RS16215	COG3409	Peptidoglycan-binding domain 1 protein
HO398_RS16220	COG3031	protein transport across the cell outer membrane
HO398_RS16225	COG1450	Type ii and iii secretion system protein
HO398_RS16230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HO398_RS16235	COG1459	type II secretion system
HO398_RS16240	COG2165	general secretion pathway protein
HO398_RS16245	COG2165	general secretion pathway protein
HO398_RS16250	COG2165	general secretion pathway protein
HO398_RS16255	COG4795	General secretion pathway protein
HO398_RS16260	COG3156	type II secretion system protein K
HO398_RS16265	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HO398_RS16270	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HO398_RS16275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HO398_RS16280	COG2193	ferroxidase activity
HO398_RS16285	COG2906	2 iron, 2 sulfur cluster binding
HO398_RS16290	COG3979	chitinase
HO398_RS16330	COG2964	Protein conserved in bacteria
HO398_RS16335	COG0545	Peptidyl-prolyl cis-trans isomerase
HO398_RS16355	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HO398_RS16370	COG0488	(ABC) transporter
HO398_RS16375	COG0429	hydrolase of the alpha beta-hydrolase fold
HO398_RS16385	COG3954	Phosphoribulokinase
HO398_RS16390	COG1765	OsmC-like protein
HO398_RS16395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HO398_RS16400	COG1289	transmembrane transporter activity
HO398_RS16405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HO398_RS16410	COG0512	Glutamine amidotransferase of anthranilate synthase
HO398_RS16415	COG2184	nucleotidyltransferase activity
HO398_RS16425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HO398_RS16435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HO398_RS16440	COG2146	nitrite reductase [NAD(P)H] activity
HO398_RS16445	COG2116	formate transmembrane transporter activity
HO398_RS16460	COG0531	amino acid
HO398_RS16465	COG2222	sugar isomerase
HO398_RS16470	COG1082	Xylose isomerase domain protein TIM barrel
HO398_RS16475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS16480	COG2188	Transcriptional regulator
HO398_RS16485	COG0626	cystathionine gamma-synthase activity
HO398_RS16510	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HO398_RS16515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HO398_RS16520	COG3457	Alanine racemase
HO398_RS16530	COG2188	Transcriptional regulator
HO398_RS16535	COG0180	Tryptophanyl-tRNA synthetase
HO398_RS16540	COG0546	phosphoglycolate phosphatase activity
HO398_RS16545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HO398_RS16550	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HO398_RS16555	COG3266	domain, Protein
HO398_RS16570	COG4796	Type ii and iii secretion system protein
HO398_RS16585	COG3166	PFAM Fimbrial assembly family protein
HO398_RS16590	COG4972	Pilus assembly protein
HO398_RS16595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HO398_RS16600	COG0494	nUDIX hydrolase
HO398_RS16610	COG1011	Hydrolase
HO398_RS16615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HO398_RS16625	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HO398_RS16635	COG2205	protein histidine kinase activity
HO398_RS16640	COG0745	RESPONSE REGULATOR receiver
HO398_RS16645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HO398_RS16650	COG2183	response to ionizing radiation
HO398_RS16655	COG1918	ferrous iron import across plasma membrane
HO398_RS16660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HO398_RS16670	COG5464	transposase or invertase
HO398_RS16690	COG2610	gluconate transmembrane transporter activity
HO398_RS16695	COG1640	4-alpha-glucanotransferase
HO398_RS16700	COG0058	SHG alpha-glucan phosphorylase activity
HO398_RS16715	COG1690	Belongs to the RtcB family
HO398_RS16720	COG4650	regulator
HO398_RS16725	COG1349	DNA-binding transcription factor activity
HO398_RS16740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HO398_RS16755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HO398_RS16760	COG0058	SHG alpha-glucan phosphorylase activity
HO398_RS16785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HO398_RS16790	COG2095	MarC family integral membrane protein
HO398_RS16795	COG2610	gluconate transmembrane transporter activity
HO398_RS16800	COG3265	gluconokinase activity
HO398_RS16805	COG1609	Transcriptional regulator
HO398_RS16810	COG1741	Belongs to the pirin family
HO398_RS16815	COG0673	inositol 2-dehydrogenase activity
HO398_RS16820	COG1247	-acetyltransferase
HO398_RS16825	COG3157	Type VI secretion system effector, Hcp
HO398_RS16845	COG0405	Gamma-glutamyltransferase
HO398_RS16855	COG0584	glycerophosphoryl diester phosphodiesterase
HO398_RS16860	COG3842	ATPase activity
HO398_RS16865	COG0395	ABC-type sugar transport system, permease component
HO398_RS16870	COG1175	transmembrane transport
HO398_RS16875	COG1653	transport
HO398_RS16880	COG0410	ABC transporter
HO398_RS16885	COG0411	ABC transporter
HO398_RS16890	COG4177	L-phenylalanine transmembrane transporter activity
HO398_RS16895	COG0559	Belongs to the binding-protein-dependent transport system permease family
HO398_RS16900	COG0683	leucine binding
HO398_RS16905	COG0456	acetyltransferase
HO398_RS16910	COG0683	leucine binding
HO398_RS16915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HO398_RS16920	COG2177	Part of the ABC transporter FtsEX involved in
HO398_RS16925	COG2884	Cell division ATP-binding protein ftsE
HO398_RS16930	COG0552	protein localization to endoplasmic reticulum
HO398_RS16935	COG0742	ribosomal rna small subunit methyltransferase
HO398_RS16940	COG3776	membrane
HO398_RS16950	COG3714	YhhN family
HO398_RS16965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HO398_RS16975	COG0477	Major facilitator Superfamily
HO398_RS16980	COG0628	permease
HO398_RS16985	COG2091	lysine biosynthetic process via aminoadipic acid
HO398_RS16990	COG0747	negative chemotaxis
HO398_RS16995	COG0601	transmembrane transport
HO398_RS17000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO398_RS17005	COG0444	Belongs to the ABC transporter superfamily
HO398_RS17020	COG3209	COG3209 Rhs family protein
HO398_RS17030	COG1413	lyase activity
HO398_RS17035	COG5433	transposase activity
HO398_RS17040	COG0842	Transport permease protein
HO398_RS17045	COG0842	Transport permease protein
HO398_RS17045	COG1129	ABC transporter
HO398_RS17050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS17070	COG2081	HI0933 family
HO398_RS17075	COG0306	phosphate transporter
HO398_RS17085	COG0589	response to stress
HO398_RS17090	COG3104	oligopeptide transport
HO398_RS17100	COG0339	signal peptide processing
HO398_RS17105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HO398_RS17110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HO398_RS17120	COG0640	Transcriptional regulator
HO398_RS17125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HO398_RS17130	COG1393	Belongs to the ArsC family
HO398_RS17140	COG3065	identical protein binding
HO398_RS17145	COG2197	response regulator
HO398_RS17150	COG1285	pathogenesis
HO398_RS17165	COG3247	response to pH
HO398_RS17170	COG2771	luxR family
HO398_RS17180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HO398_RS17185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HO398_RS17190	COG2207	Transcriptional regulator
HO398_RS17195	COG2207	Transcriptional regulator
HO398_RS17200	COG0076	glutamate decarboxylase activity
HO398_RS17205	COG1858	cytochrome C peroxidase
HO398_RS17215	COG2197	response regulator
HO398_RS17220	COG0583	DNA-binding transcription factor activity
HO398_RS17225	COG1295	ribonuclease BN
HO398_RS17230	COG0477	Major facilitator Superfamily
HO398_RS17235	COG2982	Protein involved in outer membrane biogenesis
HO398_RS17240	COG2200	EAL domain
HO398_RS17250	COG0612	Peptidase, M16
HO398_RS17260	COG2200	EAL domain
HO398_RS17260	COG2199	diguanylate cyclase activity
HO398_RS17265	COG3118	belongs to the thioredoxin family
HO398_RS17265	COG0457	Tetratricopeptide repeat
HO398_RS17270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HO398_RS17275	COG1215	transferase activity, transferring glycosyl groups
HO398_RS17280	COG1215	transferase activity, transferring glycosyl groups
HO398_RS17305	COG2194	sulfuric ester hydrolase activity
HO398_RS17325	COG0814	amino acid
HO398_RS17330	COG4608	Belongs to the ABC transporter superfamily
HO398_RS17335	COG0444	Belongs to the ABC transporter superfamily
HO398_RS17340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO398_RS17345	COG0601	transmembrane transport
HO398_RS17350	COG0747	negative chemotaxis
HO398_RS17365	COG2194	sulfuric ester hydrolase activity
HO398_RS17370	COG2223	nitrite transmembrane transporter activity
HO398_RS17375	COG5571	outer membrane autotransporter
HO398_RS17380	COG2818	Glycosylase
HO398_RS17385	COG0456	acetyltransferase
HO398_RS17390	COG0243	molybdopterin cofactor binding
HO398_RS17395	COG2885	chlorophyll binding
HO398_RS17410	COG2944	sequence-specific DNA binding
HO398_RS17415	COG1278	Cold shock
HO398_RS17445	COG3274	enterobacterial common antigen metabolic process
HO398_RS17450	COG4682	membrane
HO398_RS17455	COG4682	membrane
HO398_RS17460	COG1070	Carbohydrate kinase
HO398_RS17470	COG4213	ABC transporter substrate-binding protein
HO398_RS17480	COG4214	carbohydrate transport
HO398_RS17485	COG2207	Transcriptional regulator
HO398_RS17485	COG1609	Transcriptional regulator
HO398_RS17490	COG2992	FlgJ-related protein
HO398_RS17495	COG0366	Alpha amylase catalytic
HO398_RS17500	COG3977	Valine--pyruvate aminotransferase
HO398_RS17505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO398_RS17510	COG1414	Transcriptional regulator
HO398_RS17520	COG2731	YhcH YjgK YiaL family protein
HO398_RS17525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HO398_RS17530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HO398_RS17535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HO398_RS17540	COG1070	Carbohydrate kinase
HO398_RS17545	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HO398_RS17550	COG3623	hexulose-6-phosphate isomerase
HO398_RS17555	COG0235	Class ii aldolase
HO398_RS17565	COG2211	Major facilitator Superfamily
HO398_RS17575	COG3713	MltA-interacting MipA family protein
HO398_RS17580	COG0583	DNA-binding transcription factor activity
HO398_RS17585	COG1566	PFAM secretion protein HlyD family protein
HO398_RS17600	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS17605	COG1454	alcohol dehydrogenase
HO398_RS17610	COG3276	selenocysteine insertion sequence binding
HO398_RS17620	COG0625	glutathione transferase activity
HO398_RS17625	COG3209	COG3209 Rhs family protein
HO398_RS17625	COG3209	COG3209 Rhs family protein
HO398_RS17630	COG1413	lyase activity
HO398_RS17635	COG3209	COG3209 Rhs family protein
HO398_RS17640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HO398_RS17650	COG1566	PFAM secretion protein HlyD family protein
HO398_RS17660	COG2213	PTS system mannitol-specific
HO398_RS17660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS17670	COG3722	fumarate hydratase activity
HO398_RS17690	COG5295	Hep Hag repeat protein
HO398_RS17695	COG1620	l-lactate permease
HO398_RS17700	COG2186	Transcriptional regulator
HO398_RS17710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HO398_RS17715	COG1045	serine acetyltransferase
HO398_RS17730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HO398_RS17735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HO398_RS17745	COG4942	peptidase
HO398_RS17750	COG2861	carbohydrate metabolic process
HO398_RS17755	COG1216	Glycosyl transferase, family 2
HO398_RS17765	COG0156	8-amino-7-oxononanoate synthase activity
HO398_RS17775	COG0859	PFAM glycosyl transferase family 9
HO398_RS17780	COG0859	PFAM glycosyl transferase family 9
HO398_RS17785	COG3307	-O-antigen
HO398_RS17790	COG1216	Glycosyl transferase, family 2
HO398_RS17795	COG1442	glycosyl transferase family 8
HO398_RS17800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HO398_RS17825	COG0515	serine threonine protein kinase
HO398_RS17830	COG0438	transferase activity, transferring glycosyl groups
HO398_RS17835	COG0859	PFAM glycosyl transferase family 9
HO398_RS17840	COG1519	Transferase
HO398_RS17870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HO398_RS17895	COG1561	YicC-like family, N-terminal region
HO398_RS17900	COG3645	SOS response
HO398_RS17905	COG2860	membrane
HO398_RS17915	COG0194	GDP metabolic process
HO398_RS17925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HO398_RS17930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HO398_RS17935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HO398_RS17945	COG0786	glutamate:sodium symporter activity
HO398_RS17950	COG2233	PERMEase
HO398_RS17955	COG2982	Protein involved in outer membrane biogenesis
HO398_RS17960	COG1501	Belongs to the glycosyl hydrolase 31 family
HO398_RS17965	COG2211	Major facilitator Superfamily
HO398_RS17975	COG0582	viral genome integration into host DNA
HO398_RS17985	COG1609	Transcriptional regulator
HO398_RS17990	COG2271	Major facilitator Superfamily
HO398_RS18080	COG2814	Major facilitator Superfamily
HO398_RS18085	COG0697	spore germination
HO398_RS18090	COG1464	Belongs to the NlpA lipoprotein family
HO398_RS18110	COG2252	PERMEase
HO398_RS18120	COG2271	Major facilitator Superfamily
HO398_RS18125	COG2271	Major facilitator Superfamily
HO398_RS18130	COG3851	Histidine kinase
HO398_RS18135	COG2197	response regulator
HO398_RS18140	COG0440	acetolactate synthase activity
HO398_RS18145	COG0028	Belongs to the TPP enzyme family
HO398_RS18160	COG2814	Major facilitator Superfamily
HO398_RS18165	COG0641	radical SAM
HO398_RS18175	COG2149	membrane
HO398_RS18185	COG3119	arylsulfatase activity
HO398_RS18190	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HO398_RS18195	COG2207	Transcriptional regulator
HO398_RS18230	COG5645	(Lipo)protein
HO398_RS18235	COG0823	Involved in the tonB-independent uptake of proteins
HO398_RS18245	COG2271	Major facilitator Superfamily
HO398_RS18255	COG0800	Aldolase
HO398_RS18260	COG3734	2-keto-3-deoxy-galactonokinase
HO398_RS18265	COG2186	Transcriptional regulator
HO398_RS18275	COG0561	phosphatase activity
HO398_RS18280	COG3753	Protein conserved in bacteria
HO398_RS18285	COG0187	DNA topoisomerase II activity
HO398_RS18295	COG0592	DNA-directed DNA polymerase activity
HO398_RS18345	COG0814	amino acid
HO398_RS18360	COG2091	lysine biosynthetic process via aminoadipic acid
HO398_RS18365	COG0431	NADPH-dependent FMN reductase
HO398_RS18370	COG2252	PERMEase
HO398_RS18375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HO398_RS18385	COG3196	Protein conserved in bacteria
HO398_RS18390	COG0363	glucosamine-6-phosphate deaminase activity
HO398_RS18395	COG2382	esterase
HO398_RS18405	COG2723	6-phospho-beta-galactosidase activity
HO398_RS18410	COG2190	(PTS) system
HO398_RS18410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS18410	COG1263	PTS System
HO398_RS18415	COG3711	transcriptional antiterminator
HO398_RS18420	COG0704	Plays a role in the regulation of phosphate uptake
HO398_RS18425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HO398_RS18430	COG0581	inorganic phosphate transmembrane transporter activity
HO398_RS18435	COG0573	inorganic phosphate transmembrane transporter activity
HO398_RS18440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HO398_RS18445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HO398_RS18495	COG3312	ion transport
HO398_RS18510	COG0716	FMN binding
HO398_RS18515	COG1522	sequence-specific DNA binding
HO398_RS18555	COG1129	ABC transporter
HO398_RS18560	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS18565	COG1879	ABC-type sugar transport system periplasmic component
HO398_RS18570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS18575	COG1609	Transcriptional regulator
HO398_RS18580	COG0477	Major facilitator Superfamily
HO398_RS18585	COG2186	Transcriptional regulator
HO398_RS18625	COG3085	chromosome segregation
HO398_RS18630	COG0606	chelatase, subunit chli
HO398_RS18650	COG3978	acetolactate synthase activity
HO398_RS18655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HO398_RS18665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HO398_RS18670	COG0583	DNA-binding transcription factor activity
HO398_RS18680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HO398_RS18690	COG0210	DNA helicase
HO398_RS18705	COG3118	belongs to the thioredoxin family
HO398_RS18715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HO398_RS18720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HO398_RS18725	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HO398_RS18730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HO398_RS18735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HO398_RS18740	COG1088	dTDP-glucose 4,6-dehydratase activity
HO398_RS18745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HO398_RS18750	COG0456	acetyltransferase
HO398_RS18755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HO398_RS18760	COG2244	polysaccharide biosynthetic process
HO398_RS18780	COG1113	amino acid transport
HO398_RS18805	COG0641	radical SAM
HO398_RS18810	COG3119	arylsulfatase activity
HO398_RS18815	COG3071	HemY protein
HO398_RS18820	COG2959	enzyme of heme biosynthesis
HO398_RS18825	COG1587	Uroporphyrinogen-III synthase
HO398_RS18835	COG3072	Adenylate cyclase
HO398_RS18850	COG5567	small periplasmic lipoprotein
HO398_RS18860	COG3159	Protein conserved in bacteria
HO398_RS18870	COG1011	Hydrolase
HO398_RS18875	COG0210	DNA helicase
HO398_RS18880	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HO398_RS18885	COG3698	Phosphodiester glycosidase
HO398_RS18890	COG0598	Magnesium transport protein CorA
HO398_RS18920	COG2962	Rard protein
HO398_RS18925	COG2050	protein possibly involved in aromatic compounds catabolism
HO398_RS18930	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HO398_RS18935	COG0514	ATP-dependent DNA helicase (RecQ)
HO398_RS18940	COG1280	lysine exporter protein (LysE YggA)
HO398_RS18945	COG1280	lysine exporter protein (LysE YggA)
HO398_RS18950	COG2267	carboxylic ester hydrolase activity
HO398_RS18955	COG0561	phosphatase activity
HO398_RS18960	COG0697	spore germination
HO398_RS18965	COG0583	DNA-binding transcription factor activity
HO398_RS18970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HO398_RS18975	COG0583	DNA-binding transcription factor activity
HO398_RS18980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HO398_RS18990	COG0549	Belongs to the carbamate kinase family
HO398_RS18995	COG1304	FMN binding
HO398_RS19000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HO398_RS19010	COG1335	isochorismatase
HO398_RS19015	COG0412	Dienelactone hydrolase
HO398_RS19020	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HO398_RS19040	COG0800	Aldolase
HO398_RS19045	COG3734	2-keto-3-deoxy-galactonokinase
HO398_RS19050	COG1414	Transcriptional regulator
HO398_RS19055	COG1322	Protein conserved in bacteria
HO398_RS19065	COG3165	ubiquinone biosynthetic process from chorismate
HO398_RS19075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HO398_RS19080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HO398_RS19085	COG0805	protein transport
HO398_RS19090	COG0084	hydrolase, TatD family'
HO398_RS19095	COG0250	Participates in transcription elongation, termination and antitermination
HO398_RS19100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HO398_RS19105	COG0543	2 iron, 2 sulfur cluster binding
HO398_RS19125	COG1739	Uncharacterized protein family UPF0029
HO398_RS19130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HO398_RS19135	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HO398_RS19165	COG1763	Mo-molybdopterin cofactor biosynthetic process
HO398_RS19170	COG0746	molybdenum cofactor guanylyltransferase activity
HO398_RS19175	COG3084	Protein conserved in bacteria
HO398_RS19180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HO398_RS19185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HO398_RS19190	COG5339	Protein conserved in bacteria
HO398_RS19195	COG0204	Acyl-transferase
HO398_RS19200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HO398_RS19200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HO398_RS19215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HO398_RS19225	COG2204	response regulator
HO398_RS19230	COG3852	Histidine kinase
HO398_RS19235	COG0174	glutamine synthetase
HO398_RS19245	COG2188	Transcriptional regulator
HO398_RS19250	COG1082	Xylose isomerase domain protein TIM barrel
HO398_RS19255	COG2271	Major facilitator Superfamily
HO398_RS19260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HO398_RS19265	COG2211	Major facilitator Superfamily
HO398_RS19270	COG2211	Major facilitator Superfamily
HO398_RS19280	COG2017	converts alpha-aldose to the beta-anomer
HO398_RS19285	COG2942	2-epimerase
HO398_RS19290	COG3684	Belongs to the aldolase LacD family
HO398_RS19295	COG2084	Dehydrogenase
HO398_RS19300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HO398_RS19305	COG1349	DNA-binding transcription factor activity
HO398_RS19310	COG1011	Hydrolase
HO398_RS19325	COG0456	acetyltransferase
HO398_RS19330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HO398_RS19335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HO398_RS19345	COG2864	formate dehydrogenase
HO398_RS19350	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS19370	COG3711	transcriptional antiterminator
HO398_RS19370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS19375	COG1363	Peptidase, m42
HO398_RS19380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS19380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS19385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS19430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HO398_RS19440	COG2258	MOSC domain
HO398_RS19445	COG2205	protein histidine kinase activity
HO398_RS19450	COG0745	RESPONSE REGULATOR receiver
HO398_RS19455	COG3678	ATP-independent chaperone mediated protein folding
HO398_RS19470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HO398_RS19490	COG3152	Membrane
HO398_RS19495	COG3691	Protein conserved in bacteria
HO398_RS19500	COG0589	response to stress
HO398_RS19510	COG1494	fructose-1,6-bisphosphatase
HO398_RS19520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HO398_RS19535	COG1575	Belongs to the MenA family. Type 1 subfamily
HO398_RS19550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HO398_RS19555	COG1609	Transcriptional regulator
HO398_RS19560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HO398_RS19575	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HO398_RS19585	COG0626	cystathionine gamma-synthase activity
HO398_RS19590	COG0460	homoserine dehydrogenase
HO398_RS19590	COG0527	aspartate kinase activity
HO398_RS19595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HO398_RS19605	COG0697	spore germination
HO398_RS19610	COG3738	Protein conserved in bacteria
HO398_RS19615	COG0371	Dehydrogenase
HO398_RS19620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HO398_RS19625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS19625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS19625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO398_RS19630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS19635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS19640	COG1882	Formate acetyltransferase
HO398_RS19645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HO398_RS19650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HO398_RS19655	COG2207	Transcriptional regulator
HO398_RS19660	COG2194	sulfuric ester hydrolase activity
HO398_RS19675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HO398_RS19690	COG0583	DNA-binding transcription factor activity
HO398_RS19700	COG1309	transcriptional regulator
HO398_RS19750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HO398_RS19750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HO398_RS19785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HO398_RS19790	COG0250	Participates in transcription elongation, termination and antitermination
HO398_RS19830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HO398_RS19840	COG2104	thiamine diphosphate biosynthetic process
HO398_RS19845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HO398_RS19880	COG3068	Protein conserved in bacteria
HO398_RS19895	COG3678	ATP-independent chaperone mediated protein folding
HO398_RS19900	COG4191	Histidine kinase
HO398_RS19905	COG2204	response regulator
HO398_RS19910	COG0151	Belongs to the GarS family
HO398_RS19940	COG0456	acetyltransferase
HO398_RS19950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HO398_RS19955	COG2224	Isocitrate lyase
HO398_RS19970	COG1414	Transcriptional regulator
HO398_RS19975	COG1410	methionine synthase
HO398_RS19975	COG0646	methionine synthase
HO398_RS19980	COG1283	sodium-dependent phosphate transmembrane transporter activity
HO398_RS19990	COG1187	pseudouridine synthase activity
HO398_RS20000	COG0527	aspartate kinase activity
HO398_RS20025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO398_RS20045	COG2814	Major facilitator Superfamily
HO398_RS20045	COG0477	Major facilitator Superfamily
HO398_RS20050	COG3833	ABC-type maltose transport systems, permease component
HO398_RS20055	COG1175	transmembrane transport
HO398_RS20060	COG2182	Extracellular solute-binding protein
HO398_RS20065	COG3842	ATPase activity
HO398_RS20100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HO398_RS20110	COG0534	Mate efflux family protein
HO398_RS20115	COG3237	CsbD-like
HO398_RS20120	COG0735	belongs to the Fur family
HO398_RS20130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HO398_RS20140	COG0604	alcohol dehydrogenase
HO398_RS20145	COG0305	Participates in initiation and elongation during chromosome replication
HO398_RS20150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HO398_RS20155	COG1448	Aminotransferase
HO398_RS20165	COG3700	Belongs to the class B bacterial acid phosphatase family
HO398_RS20170	COG0432	Pfam Uncharacterised protein family UPF0047
HO398_RS20175	COG2315	Protein conserved in bacteria
HO398_RS20180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HO398_RS20185	COG0629	single-stranded DNA binding
HO398_RS20195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HO398_RS20200	COG2207	Transcriptional regulator
HO398_RS20205	COG0789	Transcriptional regulator
HO398_RS20210	COG2252	PERMEase
HO398_RS20215	COG0025	NhaP-type Na H and K H
HO398_RS20230	COG3162	membrane
HO398_RS20235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HO398_RS20245	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HO398_RS20250	COG0437	4 iron, 4 sulfur cluster binding
HO398_RS20255	COG3301	Polysulphide reductase, NrfD
HO398_RS20260	COG1138	Cytochrome C-type biogenesis protein
HO398_RS20265	COG3088	subunit of a heme lyase
HO398_RS20270	COG4235	cytochrome complex assembly
HO398_RS20275	COG1301	dicarboxylic acid transport
HO398_RS20280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HO398_RS20290	COG1538	Outer membrane efflux protein
HO398_RS20295	COG1289	transmembrane transporter activity
HO398_RS20300	COG1566	PFAM secretion protein HlyD family protein
HO398_RS20310	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HO398_RS20315	COG1940	carbohydrate kinase activity
HO398_RS20320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HO398_RS20325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS20330	COG1129	ABC transporter
HO398_RS20335	COG1879	ABC-type sugar transport system periplasmic component
HO398_RS20340	COG1737	Transcriptional regulator
HO398_RS20345	COG0698	ribose 5-phosphate isomerase
HO398_RS20355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HO398_RS20360	COG0456	acetyltransferase
HO398_RS20365	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HO398_RS20370	COG3454	Phosphonate metabolism
HO398_RS20375	COG4778	phosphonate C-P lyase system protein PhnL
HO398_RS20380	COG4107	phosphonate C-P lyase system protein PhnK
HO398_RS20385	COG3627	carbon phosphorus lyase activity
HO398_RS20390	COG3626	phosphonate metabolism
HO398_RS20395	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HO398_RS20400	COG3624	Phosphonate C-P lyase system protein PhnG
HO398_RS20405	COG2188	Transcriptional regulator
HO398_RS20410	COG3639	organic phosphonate transmembrane transporter activity
HO398_RS20415	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HO398_RS20425	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HO398_RS20430	COG2824	Alkylphosphonate utilization operon protein PhnA
HO398_RS20445	COG0477	Major facilitator Superfamily
HO398_RS20455	COG0642	Histidine kinase
HO398_RS20460	COG0745	RESPONSE REGULATOR receiver
HO398_RS20465	COG2194	sulfuric ester hydrolase activity
HO398_RS20470	COG0531	amino acid
HO398_RS20475	COG2207	Transcriptional regulator
HO398_RS20480	COG1982	Orn Lys Arg decarboxylase major
HO398_RS20485	COG2169	Transcriptional regulator
HO398_RS20490	COG1486	melibiose metabolic process
HO398_RS20495	COG2211	Major facilitator Superfamily
HO398_RS20500	COG3647	Membrane
HO398_RS20505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HO398_RS20505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HO398_RS20510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HO398_RS20515	COG4565	transcriptional regulatory protein
HO398_RS20525	COG3592	Divergent 4Fe-4S mono-cluster
HO398_RS20530	COG2388	GCN5-related N-acetyl-transferase
HO398_RS20545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HO398_RS20550	COG3104	oligopeptide transport
HO398_RS20555	COG1982	Orn Lys Arg decarboxylase major
HO398_RS20560	COG0531	amino acid
HO398_RS20565	COG3710	Transcriptional regulator
HO398_RS20575	COG1309	transcriptional regulator
HO398_RS20590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HO398_RS20595	COG1027	Aspartate ammonia-lyase
HO398_RS20600	COG3030	protein affecting phage T7 exclusion by the F plasmid
HO398_RS20605	COG0531	amino acid
HO398_RS20630	COG1509	lysine 2,3-aminomutase activity
HO398_RS20640	COG5510	response to toxic substance
HO398_RS20645	COG5510	response to toxic substance
HO398_RS20650	COG2076	Multidrug Resistance protein
HO398_RS20655	COG3040	lipid binding
HO398_RS20660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HO398_RS20675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HO398_RS20680	COG1053	succinate dehydrogenase
HO398_RS20690	COG0531	amino acid
HO398_RS20695	COG3264	Mechanosensitive ion channel
HO398_RS20695	COG1511	domain protein
HO398_RS20735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HO398_RS20740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HO398_RS20740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HO398_RS20745	COG0802	atpase or kinase
HO398_RS20750	COG0860	N-Acetylmuramoyl-L-alanine amidase
HO398_RS20770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HO398_RS20775	COG0330	HflC and HflK could
HO398_RS20780	COG0330	HflC and HflK could
HO398_RS20785	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HO398_RS20800	COG0557	exoribonuclease II activity
HO398_RS20805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HO398_RS20810	COG3789	protein conserved in bacteria
HO398_RS20815	COG1842	Phage shock protein A
HO398_RS20825	COG3766	membrane
HO398_RS20830	COG5463	Belongs to the UPF0441 family
HO398_RS20835	COG0754	glutathionylspermidine amidase activity
HO398_RS20840	COG1960	acyl-CoA dehydrogenase activity
HO398_RS20850	COG3650	response to hydrogen peroxide
HO398_RS20855	COG1073	alpha beta
HO398_RS20870	COG3037	sugar-specific permease SgaT UlaA
HO398_RS20875	COG3414	Phosphotransferase system galactitol-specific IIB component
HO398_RS20915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HO398_RS20925	COG2271	Major facilitator Superfamily
HO398_RS20930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HO398_RS20935	COG4670	ketone body catabolic process
HO398_RS20940	COG1024	Enoyl-CoA hydratase
HO398_RS20950	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS20955	COG1309	transcriptional regulator
HO398_RS20960	COG3061	Opacity-associated protein A
HO398_RS20965	COG0545	Peptidyl-prolyl cis-trans isomerase
HO398_RS20970	COG1113	amino acid transport
HO398_RS20980	COG0697	spore germination
HO398_RS20985	COG0702	epimerase
HO398_RS20990	COG1733	regulation of RNA biosynthetic process
HO398_RS20995	COG0737	Belongs to the 5'-nucleotidase family
HO398_RS21000	COG1218	3'(2'),5'-bisphosphate nucleotidase
HO398_RS21005	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HO398_RS21015	COG1253	flavin adenine dinucleotide binding
HO398_RS21025	COG0729	surface antigen
HO398_RS21030	COG2911	Protein conserved in bacteria
HO398_RS21035	COG2105	PFAM AIG2 family protein
HO398_RS21040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HO398_RS21045	COG1879	ABC-type sugar transport system periplasmic component
HO398_RS21050	COG1129	ABC transporter
HO398_RS21055	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS21060	COG1172	Belongs to the binding-protein-dependent transport system permease family
HO398_RS21070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HO398_RS21080	COG0312	modulator of DNA gyrase
HO398_RS21085	COG3783	Cytochrome b(562)
HO398_RS21090	COG0602	queuosine metabolic process
HO398_RS21095	COG1328	CTP reductase activity
HO398_RS21100	COG0366	Alpha amylase catalytic
HO398_RS21105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HO398_RS21105	COG1263	PTS System
HO398_RS21110	COG1609	Transcriptional regulator
HO398_RS21120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HO398_RS21125	COG0251	oxidation-reduction process
HO398_RS21145	COG0251	oxidation-reduction process
HO398_RS21150	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS21155	COG1309	transcriptional regulator
HO398_RS21160	COG2731	YhcH YjgK YiaL family protein
HO398_RS21175	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HO398_RS21180	COG0456	acetyltransferase
HO398_RS21185	COG4269	membrane
HO398_RS21195	COG2927	DNA polymerase III (CHI subunit)
HO398_RS21205	COG0795	lipopolysaccharide-transporting ATPase activity
HO398_RS21210	COG0795	lipopolysaccharide-transporting ATPase activity
HO398_RS21215	COG0433	COG0433 Predicted ATPase
HO398_RS21220	COG1609	Transcriptional regulator
HO398_RS21225	COG2610	gluconate transmembrane transporter activity
HO398_RS21230	COG1028	Short-chain dehydrogenase reductase Sdr
HO398_RS21235	COG1063	alcohol dehydrogenase
HO398_RS21240	COG3265	gluconokinase activity
HO398_RS21245	COG1064	alcohol dehydrogenase
HO398_RS21275	COG3385	transposase activity
HO398_RS21280	COG2814	Major facilitator Superfamily
HO398_RS21285	COG0673	inositol 2-dehydrogenase activity
HO398_RS21315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HO398_RS21330	COG2085	NADP oxidoreductase coenzyme F420-dependent
HO398_RS21335	COG1120	ATPase activity
HO398_RS21340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO398_RS21345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO398_RS21350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HO398_RS21355	COG4772	TonB-dependent receptor
HO398_RS21360	COG3712	iron ion homeostasis
HO398_RS21365	COG1595	DNA-templated transcription, initiation
HO398_RS21395	COG1349	DNA-binding transcription factor activity
HO398_RS21400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HO398_RS21405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO398_RS21410	COG0434	BtpA family
HO398_RS21415	COG3775	system Galactitol-specific IIC component
HO398_RS21420	COG3414	Phosphotransferase system galactitol-specific IIB component
HO398_RS21425	COG1363	Peptidase, m42
HO398_RS21435	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HO398_RS21440	COG3153	acetyltransferase
HO398_RS21465	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HO398_RS21470	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HO398_RS21490	COG4974	Belongs to the 'phage' integrase family
HO398_RS21495	COG3539	Fimbrial protein
HO398_RS21500	COG3539	Fimbrial protein
HO398_RS21505	COG3121	Chaperone
HO398_RS21510	COG3188	usher protein
HO398_RS21515	COG3539	Fimbrial protein
HO398_RS21520	COG3539	Fimbrial protein
HO398_RS21525	COG3539	Fimbrial protein
HO398_RS21530	COG2610	gluconate transmembrane transporter activity
HO398_RS21540	COG0246	Mannitol dehydrogenase
HO398_RS21545	COG2186	Transcriptional regulator
HO398_RS21565	COG0583	DNA-binding transcription factor activity
HO398_RS21570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HO398_RS21575	COG0700	Nucleoside recognition
HO398_RS21580	COG3366	ferrous iron transmembrane transporter activity
HO398_RS21590	COG0477	Major facilitator Superfamily
HO398_RS21595	COG3204	pilus organization
HO398_RS21605	COG1924	4 iron, 4 sulfur cluster binding
HO398_RS21610	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HO398_RS21615	COG2733	membrane
HO398_RS21620	COG2814	Major facilitator Superfamily
HO398_RS21640	COG4268	DNA restriction-modification system
HO398_RS21645	COG1401	restriction endodeoxyribonuclease activity
HO398_RS21670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HO398_RS21675	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HO398_RS21680	COG1715	Restriction endonuclease
HO398_RS21685	COG0523	cobalamin synthesis protein
HO398_RS21690	COG2879	small protein
HO398_RS21695	COG1966	Carbon starvation protein
HO398_RS21700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HO398_RS21705	COG2368	4-hydroxyphenylacetate
HO398_RS21725	COG3971	2-oxopent-4-enoate hydratase activity
HO398_RS21735	COG3384	dioxygenase
HO398_RS21740	COG1012	belongs to the aldehyde dehydrogenase family
HO398_RS21745	COG0179	Fumarylacetoacetate (FAA) hydrolase
HO398_RS21750	COG1846	Transcriptional regulator
HO398_RS21755	COG0840	transmembrane signaling receptor activity
HO398_RS21760	COG2271	Major facilitator Superfamily
HO398_RS21770	COG1063	alcohol dehydrogenase
HO398_RS21785	COG1484	DNA-dependent DNA replication
HO398_RS21800	COG2966	Psort location CytoplasmicMembrane, score
HO398_RS21805	COG2197	response regulator
HO398_RS21810	COG2197	response regulator
HO398_RS21815	COG4114	ferric iron reductase
HO398_RS21845	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HO398_RS21850	COG0456	acetyltransferase
HO398_RS21855	COG1011	Hydrolase
HO398_RS21865	COG2823	Periplasmic or secreted lipoprotein
HO398_RS21875	COG4667	esterase of the alpha-beta hydrolase superfamily
HO398_RS21880	COG0084	hydrolase, TatD family'
HO398_RS21885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HO398_RS21890	COG1328	CTP reductase activity
HO398_RS21925	COG3726	membrane protein affecting hemolysin expression
HO398_RS21930	COG0560	Phosphoserine phosphatase
HO398_RS21935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HO398_RS21940	COG1056	cytidyltransferase-related domain
HO398_RS21940	COG3172	ATPase kinase involved in NAD metabolism
HO398_RS21945	COG0488	(ABC) transporter
HO398_RS21950	COG0741	lytic transglycosylase activity
HO398_RS21970	COG3708	Transcriptional regulator
HO398_RS21970	COG2207	Transcriptional regulator
HO398_RS21975	COG3045	CreA protein
HO398_RS21980	COG0745	RESPONSE REGULATOR receiver
HO398_RS21985	COG2205	protein histidine kinase activity
HO398_RS21990	COG4452	Inner membrane protein CreD
HO398_RS21995	COG0745	RESPONSE REGULATOR receiver
HO398_RS22005	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA