locus-tag	class	description
I3S_RS00010	COG0460	homoserine dehydrogenase
I3S_RS00010	COG0527	aspartate kinase activity
I3S_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3S_RS00035	COG1115	amino acid carrier protein
I3S_RS00040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3S_RS00045	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3S_RS00050	COG1584	GPR1 FUN34 yaaH family protein
I3S_RS00055	COG4735	regulation of single-species biofilm formation
I3S_RS00085	COG3119	arylsulfatase activity
I3S_RS00100	COG0583	DNA-binding transcription factor activity
I3S_RS00135	COG0196	riboflavin kinase activity
I3S_RS00150	COG1047	Peptidyl-prolyl cis-trans
I3S_RS00175	COG0505	Belongs to the CarA family
I3S_RS00180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3S_RS00235	COG0644	oxidoreductase
I3S_RS00240	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3S_RS00245	COG2271	Major facilitator Superfamily
I3S_RS00265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I3S_RS00290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3S_RS00295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3S_RS00300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I3S_RS00305	COG0564	pseudouridine synthase activity
I3S_RS00315	COG0417	DNA replication proofreading
I3S_RS00320	COG0235	Class ii aldolase
I3S_RS00330	COG1069	ribulokinase activity
I3S_RS00345	COG0586	Pfam SNARE associated Golgi protein
I3S_RS00355	COG1178	ABC-type Fe3 transport system permease component
I3S_RS00360	COG4143	(ABC) transporter
I3S_RS00375	COG2814	Major facilitator Superfamily
I3S_RS00390	COG0473	3-isopropylmalate dehydrogenase activity
I3S_RS00405	COG0583	DNA-binding transcription factor activity
I3S_RS00410	COG0028	Belongs to the TPP enzyme family
I3S_RS00415	COG0440	acetolactate synthase activity
I3S_RS00425	COG1609	Transcriptional regulator
I3S_RS00450	COG3116	cell division
I3S_RS00455	COG0768	penicillin binding
I3S_RS00460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3S_RS00465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3S_RS00480	COG0772	Belongs to the SEDS family
I3S_RS00495	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3S_RS00500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3S_RS00505	COG0849	cell division
I3S_RS00510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3S_RS00530	COG0494	nUDIX hydrolase
I3S_RS00545	COG0237	dephospho-CoA kinase activity
I3S_RS00555	COG1459	type II secretion system
I3S_RS00560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3S_RS00565	COG4969	Belongs to the N-Me-Phe pilin family
I3S_RS00575	COG0157	Belongs to the NadC ModD family
I3S_RS00580	COG3023	N-Acetylmuramoyl-L-alanine amidase
I3S_RS00585	COG3725	Membrane protein required for beta-lactamase induction
I3S_RS00590	COG1113	amino acid transport
I3S_RS00595	COG2186	Transcriptional regulator
I3S_RS00605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3S_RS00610	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3S_RS00615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3S_RS00620	COG3064	Membrane
I3S_RS00630	COG1049	propionate catabolic process, 2-methylcitrate cycle
I3S_RS00655	COG2132	Multicopper oxidase
I3S_RS00660	COG4993	Dehydrogenase
I3S_RS00665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3S_RS00670	COG0288	reversible hydration of carbon dioxide
I3S_RS00675	COG1131	(ABC) transporter
I3S_RS00680	COG0842	Transport permease protein
I3S_RS00685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS00690	COG0726	polysaccharide deacetylase
I3S_RS00705	COG5464	transposase or invertase
I3S_RS00740	COG3539	Fimbrial protein
I3S_RS00745	COG3539	Fimbrial protein
I3S_RS00750	COG3539	Fimbrial protein
I3S_RS00755	COG3188	usher protein
I3S_RS00760	COG3121	Chaperone
I3S_RS00765	COG3539	Fimbrial protein
I3S_RS00770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I3S_RS00775	COG0617	tRNA 3'-terminal CCA addition
I3S_RS00785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3S_RS00795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I3S_RS00800	COG1643	Atp-dependent helicase
I3S_RS00810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3S_RS00820	COG1120	ATPase activity
I3S_RS00825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3S_RS00830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3S_RS00850	COG2860	membrane
I3S_RS00855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3S_RS00875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3S_RS00880	COG3835	regulator
I3S_RS00900	COG0024	Methionine aminopeptidase
I3S_RS00935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3S_RS00940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3S_RS00945	COG0575	Belongs to the CDS family
I3S_RS00950	COG0750	zinc metalloprotease
I3S_RS00960	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I3S_RS00965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3S_RS00990	COG0587	DNA-directed DNA polymerase activity
I3S_RS01000	COG1982	Orn Lys Arg decarboxylase major
I3S_RS01005	COG0346	lactoylglutathione lyase activity
I3S_RS01015	COG4568	rho-dependent transcription termination
I3S_RS01025	COG4681	YaeQ
I3S_RS01030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3S_RS01035	COG3015	lipoprotein NlpE involved in copper resistance
I3S_RS01050	COG1720	tRNA m6t6A37 methyltransferase activity
I3S_RS01060	COG1464	Belongs to the NlpA lipoprotein family
I3S_RS01065	COG2011	ABC-type metal ion transport system permease component
I3S_RS01070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3S_RS01075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3S_RS01110	COG0656	L-ascorbic acid biosynthetic process
I3S_RS01115	COG0583	DNA-binding transcription factor activity
I3S_RS01125	COG2226	methyltransferase
I3S_RS01130	COG0741	lytic transglycosylase activity
I3S_RS01130	COG1388	LysM domain
I3S_RS01140	COG2226	methyltransferase
I3S_RS01150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS01180	COG3157	Type VI secretion system effector, Hcp
I3S_RS01285	COG3209	COG3209 Rhs family protein
I3S_RS01305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3S_RS01315	COG1960	acyl-CoA dehydrogenase activity
I3S_RS01325	COG0121	glutamine amidotransferase
I3S_RS01330	COG3034	peptidoglycan biosynthetic process
I3S_RS01335	COG3041	Addiction module toxin RelE StbE family
I3S_RS01340	COG3077	Addiction module antitoxin, RelB DinJ family
I3S_RS01345	COG0791	NLP P60 protein
I3S_RS01375	COG0454	-acetyltransferase
I3S_RS01385	COG1690	Belongs to the RtcB family
I3S_RS01390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3S_RS01395	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3S_RS01415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3S_RS01435	COG0583	DNA-binding transcription factor activity
I3S_RS01440	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3S_RS01445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3S_RS01450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3S_RS01455	COG2080	2 iron, 2 sulfur cluster binding
I3S_RS01470	COG0727	PFAM Uncharacterised protein family (UPF0153)
I3S_RS01475	COG3121	Chaperone
I3S_RS01485	COG3188	usher protein
I3S_RS01540	COG1388	LysM domain
I3S_RS01545	COG2207	Transcriptional regulator
I3S_RS01545	COG3708	Transcriptional regulator
I3S_RS01550	COG0656	L-ascorbic acid biosynthetic process
I3S_RS01565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3S_RS01570	COG2207	Transcriptional regulator
I3S_RS01575	COG0247	lactate metabolic process
I3S_RS01580	COG1139	Iron-sulfur cluster binding protein
I3S_RS01585	COG1556	Lactate utilization protein
I3S_RS01625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3S_RS01635	COG2200	EAL domain
I3S_RS01635	COG2771	luxR family
I3S_RS01640	COG0583	DNA-binding transcription factor activity
I3S_RS01655	COG0666	response to abiotic stimulus
I3S_RS01665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3S_RS01670	COG1304	FMN binding
I3S_RS01675	COG0549	Belongs to the carbamate kinase family
I3S_RS01680	COG0402	S-adenosylhomocysteine deaminase activity
I3S_RS01690	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS01695	COG1129	ABC transporter
I3S_RS01700	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS01710	COG1064	alcohol dehydrogenase
I3S_RS01725	COG1280	lysine exporter protein (LysE YggA)
I3S_RS01735	COG3829	transcription factor binding
I3S_RS01740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3S_RS01745	COG0372	Belongs to the citrate synthase family
I3S_RS01750	COG2079	MmgE PrpD family protein
I3S_RS01755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3S_RS01760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I3S_RS01765	COG0402	S-adenosylhomocysteine deaminase activity
I3S_RS01770	COG0583	DNA-binding transcription factor activity
I3S_RS01775	COG0288	reversible hydration of carbon dioxide
I3S_RS01785	COG2807	transmembrane transport
I3S_RS01790	COG0110	maltose O-acetyltransferase activity
I3S_RS01795	COG2223	nitrite transmembrane transporter activity
I3S_RS01815	COG1609	Transcriptional regulator
I3S_RS01820	COG1414	Transcriptional regulator
I3S_RS01855	COG2814	Major facilitator Superfamily
I3S_RS01860	COG3122	Protein conserved in bacteria
I3S_RS01890	COG1215	transferase activity, transferring glycosyl groups
I3S_RS01895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3S_RS01905	COG4521	taurine ABC transporter
I3S_RS01915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3S_RS01920	COG2175	clavaminate synthase activity
I3S_RS01925	COG0113	porphobilinogen synthase activity
I3S_RS01935	COG3468	outer membrane autotransporter barrel domain protein
I3S_RS01940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3S_RS01945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3S_RS01955	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I3S_RS01980	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3S_RS01995	COG1785	Belongs to the alkaline phosphatase family
I3S_RS02005	COG3706	GGDEF domain
I3S_RS02010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3S_RS02035	COG4126	flavin adenine dinucleotide binding
I3S_RS02065	COG2814	Major facilitator Superfamily
I3S_RS02070	COG0419	ATPase involved in DNA repair
I3S_RS02075	COG0420	3'-5' exonuclease activity
I3S_RS02080	COG0745	RESPONSE REGULATOR receiver
I3S_RS02085	COG5002	protein histidine kinase activity
I3S_RS02090	COG1114	Component of the transport system for branched-chain amino acids
I3S_RS02095	COG1113	amino acid transport
I3S_RS02100	COG0366	Alpha amylase catalytic
I3S_RS02120	COG1862	Preprotein translocase
I3S_RS02125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3S_RS02130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3S_RS02135	COG1403	HNH endonuclease
I3S_RS02140	COG3248	Nucleoside-binding outer membrane protein
I3S_RS02145	COG4238	major outer membrane lipoprotein
I3S_RS02155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3S_RS02155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3S_RS02170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I3S_RS02175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I3S_RS02180	COG0667	Aldo Keto reductase
I3S_RS02190	COG0142	geranyltranstransferase activity
I3S_RS02205	COG0693	protein deglycase activity
I3S_RS02210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3S_RS02220	COG2814	Major facilitator Superfamily
I3S_RS02245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I3S_RS02250	COG1845	cytochrome c oxidase, subunit III
I3S_RS02255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3S_RS02260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3S_RS02265	COG2223	nitrite transmembrane transporter activity
I3S_RS02270	COG3056	Lipoprotein
I3S_RS02275	COG0271	Belongs to the BolA IbaG family
I3S_RS02300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3S_RS02305	COG0776	regulation of translation
I3S_RS02310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3S_RS02315	COG1555	photosystem II stabilization
I3S_RS02320	COG0824	Thioesterase
I3S_RS02330	COG4533	DNA binding
I3S_RS02340	COG1522	sequence-specific DNA binding
I3S_RS02345	COG1132	(ABC) transporter
I3S_RS02350	COG1132	(ABC) transporter
I3S_RS02355	COG0347	Belongs to the P(II) protein family
I3S_RS02360	COG0004	ammonium transporteR
I3S_RS02365	COG1946	Acyl-CoA thioesterase
I3S_RS02370	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I3S_RS02375	COG3695	enzyme binding
I3S_RS02385	COG5507	3-demethylubiquinone-9 3-methyltransferase
I3S_RS02390	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I3S_RS02400	COG0110	maltose O-acetyltransferase activity
I3S_RS02415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3S_RS02420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS02425	COG1309	transcriptional regulator
I3S_RS02435	COG1196	nuclear chromosome segregation
I3S_RS02435	COG3264	Mechanosensitive ion channel
I3S_RS02445	COG3923	Primosomal replication protein n
I3S_RS02450	COG2832	Protein of unknown function (DUF454)
I3S_RS02465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3S_RS02505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS02510	COG4651	solute:proton antiporter activity
I3S_RS02510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3S_RS02515	COG2223	nitrite transmembrane transporter activity
I3S_RS02525	COG0737	Belongs to the 5'-nucleotidase family
I3S_RS02530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3S_RS02540	COG3735	TraB family
I3S_RS02550	COG3093	addiction module antidote protein HigA
I3S_RS02555	COG2217	Heavy metal translocating P-type atpase
I3S_RS02565	COG0531	amino acid
I3S_RS02570	COG0789	Transcriptional regulator
I3S_RS02575	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3S_RS02580	COG0330	HflC and HflK could
I3S_RS02585	COG4619	ABC transporter
I3S_RS02590	COG0390	transport system, permease component
I3S_RS02595	COG3118	belongs to the thioredoxin family
I3S_RS02600	COG0300	oxidoreductase activity
I3S_RS02605	COG2755	lipolytic protein G-D-S-L family
I3S_RS02610	COG4181	ATPase activity
I3S_RS02615	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I3S_RS02620	COG3209	COG3209 Rhs family protein
I3S_RS02640	COG0583	DNA-binding transcription factor activity
I3S_RS02650	COG1414	Transcriptional regulator
I3S_RS02655	COG3960	tartronate-semialdehyde synthase activity
I3S_RS02660	COG3622	Belongs to the hyi family
I3S_RS02665	COG2084	Dehydrogenase
I3S_RS02670	COG1953	Uracil, thiamine, allantoin
I3S_RS02680	COG2233	PERMEase
I3S_RS02685	COG1929	Belongs to the glycerate kinase type-1 family
I3S_RS02690	COG3257	ureidoglycine aminohydrolase activity
I3S_RS02695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3S_RS02700	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I3S_RS02705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3S_RS02710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3S_RS02720	COG0549	Belongs to the carbamate kinase family
I3S_RS02725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3S_RS02730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3S_RS02745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3S_RS02755	COG1988	membrane-bound metal-dependent
I3S_RS02760	COG2501	S4 domain
I3S_RS02770	COG3539	Fimbrial protein
I3S_RS02780	COG3188	usher protein
I3S_RS02785	COG3539	Fimbrial protein
I3S_RS02790	COG3539	Fimbrial protein
I3S_RS02795	COG2197	response regulator
I3S_RS02805	COG0582	viral genome integration into host DNA
I3S_RS02835	COG4220	transposase activity
I3S_RS02855	COG1030	water channel activity
I3S_RS02905	COG1196	nuclear chromosome segregation
I3S_RS02955	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS02960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3S_RS02970	COG0500	methyltransferase
I3S_RS02985	COG4571	Outer membrane protease
I3S_RS03000	COG2207	Transcriptional regulator
I3S_RS03015	COG4783	chaperone-mediated protein folding
I3S_RS03020	COG1215	transferase activity, transferring glycosyl groups
I3S_RS03025	COG5433	transposase activity
I3S_RS03075	COG4104	PAAR repeat-containing protein
I3S_RS03075	COG3209	COG3209 Rhs family protein
I3S_RS03085	COG3501	Rhs element vgr protein
I3S_RS03090	COG5002	protein histidine kinase activity
I3S_RS03095	COG0745	RESPONSE REGULATOR receiver
I3S_RS03105	COG1538	Outer membrane efflux protein
I3S_RS03110	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS03115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS03120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3S_RS03125	COG1113	amino acid transport
I3S_RS03130	COG0668	transmembrane transport
I3S_RS03135	COG0778	Nitroreductase
I3S_RS03140	COG2315	Protein conserved in bacteria
I3S_RS03175	COG2977	Belongs to the P-Pant transferase superfamily
I3S_RS03180	COG4771	TonB-dependent receptor
I3S_RS03190	COG2382	esterase
I3S_RS03195	COG3251	PFAM MbtH domain protein
I3S_RS03200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3S_RS03200	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3S_RS03205	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3S_RS03210	COG1120	ATPase activity
I3S_RS03215	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3S_RS03220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3S_RS03230	COG4592	Periplasmic binding protein
I3S_RS03240	COG1169	isochorismate synthase
I3S_RS03245	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3S_RS03250	COG3433	isochorismatase activity
I3S_RS03250	COG1535	isochorismatase
I3S_RS03255	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS03260	COG2050	protein possibly involved in aromatic compounds catabolism
I3S_RS03265	COG1966	Carbon starvation protein
I3S_RS03270	COG2879	small protein
I3S_RS03275	COG0371	Dehydrogenase
I3S_RS03280	COG0436	Aminotransferase
I3S_RS03285	COG1475	DNA binding
I3S_RS03290	COG3969	phosphoadenosine phosphosulfate
I3S_RS03295	COG0583	DNA-binding transcription factor activity
I3S_RS03300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3S_RS03305	COG0450	alkyl hydroperoxide reductase
I3S_RS03310	COG3634	alkyl hydroperoxide reductase activity
I3S_RS03315	COG0589	response to stress
I3S_RS03320	COG1063	alcohol dehydrogenase
I3S_RS03330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3S_RS03340	COG3719	Belongs to the RNase T2 family
I3S_RS03345	COG0471	metal ion transport
I3S_RS03360	COG3051	citrate lyase alpha subunit
I3S_RS03365	COG2301	Belongs to the HpcH HpaI aldolase family
I3S_RS03375	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I3S_RS03380	COG3290	protein histidine kinase activity
I3S_RS03385	COG4565	transcriptional regulatory protein
I3S_RS03390	COG3069	C4-dicarboxylate transmembrane transporter activity
I3S_RS03415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3S_RS03420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3S_RS03435	COG0583	DNA-binding transcription factor activity
I3S_RS03455	COG1686	Belongs to the peptidase S11 family
I3S_RS03460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3S_RS03465	COG0772	Belongs to the SEDS family
I3S_RS03470	COG0768	penicillin binding
I3S_RS03480	COG0799	negative regulation of ribosome biogenesis
I3S_RS03485	COG0406	alpha-ribazole phosphatase activity
I3S_RS03495	COG1466	dna polymerase III delta subunit
I3S_RS03510	COG2888	peptidyl-tyrosine sulfation
I3S_RS03515	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3S_RS03525	COG2214	Heat shock protein DnaJ domain protein
I3S_RS03530	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3S_RS03540	COG2214	Heat shock protein DnaJ domain protein
I3S_RS03545	COG0443	Heat shock 70 kDa protein
I3S_RS03555	COG1126	abc transporter atp-binding protein
I3S_RS03560	COG0765	amino acid transport
I3S_RS03565	COG0765	amino acid transport
I3S_RS03570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS03585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3S_RS03590	COG4535	Mg2 and Co2 transporter CorC
I3S_RS03600	COG1702	phosphate starvation-inducible protein PhoH
I3S_RS03610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3S_RS03655	COG0367	asparagine synthase
I3S_RS03665	COG0647	UMP catabolic process
I3S_RS03670	COG1940	carbohydrate kinase activity
I3S_RS03670	COG1846	Transcriptional regulator
I3S_RS03675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3S_RS03685	COG1263	PTS System
I3S_RS03685	COG2190	(PTS) system
I3S_RS03685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS03705	COG0735	belongs to the Fur family
I3S_RS03715	COG0716	FMN binding
I3S_RS03725	COG0596	Alpha beta hydrolase
I3S_RS03730	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I3S_RS03735	COG0033	Phosphoglucomutase
I3S_RS03740	COG0531	amino acid
I3S_RS03745	COG1982	Orn Lys Arg decarboxylase major
I3S_RS03755	COG0745	RESPONSE REGULATOR receiver
I3S_RS03760	COG2205	protein histidine kinase activity
I3S_RS03860	COG3272	Protein of unknown function (DUF1722)
I3S_RS03865	COG0415	Belongs to the DNA photolyase family
I3S_RS03875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3S_RS03880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3S_RS03885	COG1984	allophanate hydrolase subunit 2
I3S_RS03900	COG3180	Ammonia monooxygenase
I3S_RS03905	COG3539	Fimbrial protein
I3S_RS03910	COG3121	Chaperone
I3S_RS03915	COG3188	usher protein
I3S_RS03920	COG3539	Fimbrial protein
I3S_RS03925	COG0372	Belongs to the citrate synthase family
I3S_RS03940	COG2009	succinate dehydrogenase
I3S_RS03945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I3S_RS03950	COG1053	succinate dehydrogenase
I3S_RS03955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3S_RS03960	COG0567	Dehydrogenase, E1 component
I3S_RS03965	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3S_RS03975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3S_RS03980	COG2188	Transcriptional regulator
I3S_RS03985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS03985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS03985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS03990	COG0383	alpha-mannosidase activity
I3S_RS04000	COG1271	oxidase subunit
I3S_RS04005	COG1294	oxidase, subunit
I3S_RS04010	COG4890	Cyd operon protein YbgT
I3S_RS04015	COG3790	cyd operon protein YbgE
I3S_RS04020	COG0824	Thioesterase
I3S_RS04025	COG0811	peptide transport
I3S_RS04030	COG0848	biopolymer transport protein
I3S_RS04035	COG3064	Membrane
I3S_RS04045	COG2885	chlorophyll binding
I3S_RS04050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I3S_RS04095	COG3201	nicotinamide mononucleotide transporter
I3S_RS04100	COG1230	cation diffusion facilitator family transporter
I3S_RS04115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3S_RS04125	COG2017	converts alpha-aldose to the beta-anomer
I3S_RS04135	COG1085	galactose-1-phosphate uridylyltransferase
I3S_RS04140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3S_RS04145	COG1119	ATPase activity
I3S_RS04150	COG3585	molybdate ion transport
I3S_RS04150	COG2005	Transcriptional regulator
I3S_RS04165	COG0725	ABC transporter, periplasmic molybdate-binding protein
I3S_RS04170	COG4149	molybdate abc transporter
I3S_RS04180	COG0561	phosphatase activity
I3S_RS04190	COG0583	DNA-binding transcription factor activity
I3S_RS04195	COG2828	Protein conserved in bacteria
I3S_RS04200	COG0471	metal ion transport
I3S_RS04205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3S_RS04210	COG4677	pectinesterase activity
I3S_RS04220	COG1881	PFAM PEBP family protein
I3S_RS04225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3S_RS04240	COG2226	methyltransferase
I3S_RS04245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3S_RS04255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3S_RS04265	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3S_RS04275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I3S_RS04280	COG0314	molybdopterin synthase activity
I3S_RS04285	COG0670	Belongs to the BI1 family
I3S_RS04295	COG0670	Belongs to the BI1 family
I3S_RS04300	COG0392	lysyltransferase activity
I3S_RS04305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3S_RS04310	COG3568	Endonuclease Exonuclease Phosphatase
I3S_RS04320	COG0842	Transport permease protein
I3S_RS04325	COG0842	Transport permease protein
I3S_RS04330	COG1131	(ABC) transporter
I3S_RS04340	COG1309	transcriptional regulator
I3S_RS04345	COG0513	Belongs to the DEAD box helicase family
I3S_RS04350	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I3S_RS04360	COG1199	ATP-dependent helicase activity
I3S_RS04365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3S_RS04370	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I3S_RS04380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3S_RS04390	COG4774	siderophore transport
I3S_RS04405	COG0668	transmembrane transport
I3S_RS04410	COG1126	abc transporter atp-binding protein
I3S_RS04415	COG0765	amino acid transport
I3S_RS04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS04445	COG5006	permease, DMT superfamily
I3S_RS04450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I3S_RS04455	COG2194	sulfuric ester hydrolase activity
I3S_RS04465	COG1321	iron dependent repressor
I3S_RS04470	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3S_RS04475	COG1376	ErfK ybiS ycfS ynhG family protein
I3S_RS04480	COG0488	(ABC) transporter
I3S_RS04490	COG0561	phosphatase activity
I3S_RS04495	COG1882	Formate acetyltransferase
I3S_RS04500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3S_RS04505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3S_RS04510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3S_RS04515	COG0303	'Molybdopterin
I3S_RS04520	COG1446	asparaginase
I3S_RS04545	COG2200	EAL domain
I3S_RS04550	COG2199	diguanylate cyclase activity
I3S_RS04565	COG2133	pyrroloquinoline quinone binding
I3S_RS04575	COG1686	Belongs to the peptidase S11 family
I3S_RS04580	COG1349	DNA-binding transcription factor activity
I3S_RS04585	COG0671	phosphoesterase, PA-phosphatase related
I3S_RS04590	COG2814	Major facilitator Superfamily
I3S_RS04600	COG0561	phosphatase activity
I3S_RS04605	COG0738	Major facilitator superfamily
I3S_RS04610	COG3226	Transcriptional regulator
I3S_RS04625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3S_RS04635	COG0778	Nitroreductase
I3S_RS04655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3S_RS04660	COG3842	ATPase activity
I3S_RS04665	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3S_RS04670	COG1177	transmembrane transport
I3S_RS04685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS04690	COG4160	amino acid transport
I3S_RS04695	COG4215	(ABC) transporter
I3S_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS04705	COG1126	abc transporter atp-binding protein
I3S_RS04720	COG3023	N-Acetylmuramoyl-L-alanine amidase
I3S_RS04725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3S_RS04730	COG0702	epimerase
I3S_RS04735	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I3S_RS04740	COG0028	Belongs to the TPP enzyme family
I3S_RS04745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3S_RS04755	COG2431	L-lysine efflux transmembrane transporter activity
I3S_RS04770	COG3593	DNA synthesis involved in DNA repair
I3S_RS04775	COG2990	Protein conserved in bacteria
I3S_RS04780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS04790	COG1278	Cold shock
I3S_RS04800	COG0542	response to heat
I3S_RS04805	COG4372	Transposase
I3S_RS04810	COG3436	PFAM IS66 Orf2 family protein
I3S_RS04835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3S_RS04840	COG4988	ABC transporter
I3S_RS04845	COG0492	ferredoxin-NADP+ reductase activity
I3S_RS04855	COG1522	sequence-specific DNA binding
I3S_RS04860	COG1178	ABC-type Fe3 transport system permease component
I3S_RS04860	COG1674	ftsk spoiiie
I3S_RS04870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3S_RS04880	COG0243	molybdopterin cofactor binding
I3S_RS04885	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS04890	COG3302	dmso reductase anchor subunit
I3S_RS04895	COG1335	isochorismatase
I3S_RS04905	COG0531	amino acid
I3S_RS04910	COG0583	DNA-binding transcription factor activity
I3S_RS04915	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3S_RS04920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3S_RS04925	COG1882	Formate acetyltransferase
I3S_RS04930	COG2116	formate transmembrane transporter activity
I3S_RS04935	COG1944	ATP diphosphatase activity
I3S_RS04940	COG2323	membrane
I3S_RS04955	COG0501	Belongs to the peptidase M48B family
I3S_RS04965	COG0539	negative regulation of cytoplasmic translation
I3S_RS04975	COG2333	competence protein COMEC
I3S_RS04975	COG0658	competence protein
I3S_RS04980	COG1132	(ABC) transporter
I3S_RS04990	COG3214	Protein conserved in bacteria
I3S_RS05005	COG3173	Aminoglycoside phosphotransferase
I3S_RS05010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3S_RS05015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3S_RS05025	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I3S_RS05035	COG2989	Protein conserved in bacteria
I3S_RS05045	COG3108	Peptidase M15
I3S_RS05050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3S_RS05055	COG1448	Aminotransferase
I3S_RS05075	COG0308	aminopeptidase N
I3S_RS05085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3S_RS05095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3S_RS05100	COG0431	NADPH-dependent FMN reductase
I3S_RS05105	COG3539	Fimbrial protein
I3S_RS05120	COG3539	Fimbrial protein
I3S_RS05125	COG3539	Fimbrial protein
I3S_RS05130	COG3539	Fimbrial protein
I3S_RS05135	COG3121	Chaperone
I3S_RS05150	COG3217	Mosc domain protein beta barrel domain protein
I3S_RS05150	COG0633	Ferredoxin
I3S_RS05160	COG0488	(ABC) transporter
I3S_RS05165	COG2995	paraquat-inducible protein a
I3S_RS05170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3S_RS05170	COG3008	intermembrane lipid transfer
I3S_RS05175	COG3009	Protein conserved in bacteria
I3S_RS05180	COG3130	regulation of translation
I3S_RS05190	COG1067	ATP-dependent peptidase activity
I3S_RS05215	COG3070	regulator of competence-specific genes
I3S_RS05220	COG1289	transmembrane transporter activity
I3S_RS05225	COG3304	Inner membrane component domain
I3S_RS05230	COG0210	DNA helicase
I3S_RS05245	COG1832	CoA-binding protein
I3S_RS05260	COG1254	Belongs to the acylphosphatase family
I3S_RS05265	COG2920	part of a sulfur-relay system
I3S_RS05270	COG0670	Belongs to the BI1 family
I3S_RS05285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS05320	COG4197	protein conserved in bacteria, prophage-related
I3S_RS05395	COG1403	HNH endonuclease
I3S_RS05400	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3S_RS05445	COG3772	lysozyme
I3S_RS05480	COG0740	serine-type endopeptidase activity
I3S_RS05595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS05670	COG1484	DNA-dependent DNA replication
I3S_RS05675	COG1846	Transcriptional regulator
I3S_RS05705	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3S_RS05725	COG2207	Transcriptional regulator
I3S_RS05785	COG3772	lysozyme
I3S_RS05815	COG4220	transposase activity
I3S_RS05920	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS05960	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS05965	COG0745	RESPONSE REGULATOR receiver
I3S_RS05970	COG3005	denitrification pathway
I3S_RS05975	COG0243	molybdopterin cofactor binding
I3S_RS06020	COG3729	General stress protein
I3S_RS06025	COG2233	PERMEase
I3S_RS06060	COG1309	transcriptional regulator
I3S_RS06065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3S_RS06065	COG0506	proline dehydrogenase activity
I3S_RS06065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3S_RS06080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3S_RS06100	COG2822	iron ion transport
I3S_RS06110	COG1702	phosphate starvation-inducible protein PhoH
I3S_RS06140	COG3381	protein complex oligomerization
I3S_RS06150	COG1462	curli production assembly transport component CsgG
I3S_RS06165	COG2197	response regulator
I3S_RS06200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3S_RS06205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3S_RS06230	COG2943	transferase activity, transferring hexosyl groups
I3S_RS06235	COG5645	(Lipo)protein
I3S_RS06250	COG1560	Kdo2-lipid A biosynthetic process
I3S_RS06260	COG2353	YceI-like domain
I3S_RS06265	COG3038	cytochrome b561
I3S_RS06305	COG2999	glutathione oxidoreductase activity
I3S_RS06315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3S_RS06325	COG0673	inositol 2-dehydrogenase activity
I3S_RS06330	COG0728	peptidoglycan biosynthetic process
I3S_RS06335	COG3418	PFAM FlgN family protein
I3S_RS06340	COG2747	anti-sigma28 factor FlgM
I3S_RS06345	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I3S_RS06350	COG1815	bacterial-type flagellum-dependent cell motility
I3S_RS06355	COG1558	bacterial-type flagellum-dependent cell motility
I3S_RS06360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I3S_RS06365	COG1749	Flagellar hook protein flgE
I3S_RS06370	COG4787	bacterial-type flagellum-dependent cell motility
I3S_RS06375	COG4786	Flagellar basal body rod
I3S_RS06390	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3S_RS06390	COG3951	Flagellar rod assembly protein muramidase FlgJ
I3S_RS06395	COG1256	bacterial-type flagellum assembly
I3S_RS06400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3S_RS06405	COG1530	ribonuclease E activity
I3S_RS06415	COG0564	pseudouridine synthase activity
I3S_RS06420	COG0424	maF-like protein
I3S_RS06425	COG1399	metal-binding, possibly nucleic acid-binding protein
I3S_RS06445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I3S_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS06460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3S_RS06465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3S_RS06470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3S_RS06480	COG0470	DNA polymerase III
I3S_RS06485	COG0084	hydrolase, TatD family'
I3S_RS06490	COG1263	PTS System
I3S_RS06490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS06495	COG4773	Receptor
I3S_RS06500	COG0537	adenosine 5'-monophosphoramidase activity
I3S_RS06505	COG5633	Lipoprotein
I3S_RS06510	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I3S_RS06530	COG1252	NADH dehydrogenase
I3S_RS06540	COG3134	Outer membrane lipoprotein
I3S_RS06545	COG1309	transcriptional regulator
I3S_RS06555	COG1388	LysM domain
I3S_RS06555	COG1376	ErfK ybiS ycfS ynhG family protein
I3S_RS06560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I3S_RS06565	COG4763	Acyl-transferase
I3S_RS06570	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3S_RS06580	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3S_RS06590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3S_RS06595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3S_RS06600	COG1177	transmembrane transport
I3S_RS06615	COG0582	viral genome integration into host DNA
I3S_RS06625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS06675	COG1846	Transcriptional regulator
I3S_RS06695	COG4372	Transposase
I3S_RS06700	COG3436	PFAM IS66 Orf2 family protein
I3S_RS06735	COG3111	PFAM Bacterial OB fold (BOF) protein
I3S_RS06745	COG1403	HNH endonuclease
I3S_RS06750	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3S_RS06755	COG0484	heat shock protein binding
I3S_RS06840	COG3772	lysozyme
I3S_RS06965	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS06995	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I3S_RS07000	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I3S_RS07005	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3S_RS07010	COG1999	signal sequence binding
I3S_RS07015	COG1773	rubredoxin
I3S_RS07020	COG1271	oxidase subunit
I3S_RS07025	COG1294	oxidase, subunit
I3S_RS07040	COG3206	protein involved in exopolysaccharide biosynthesis
I3S_RS07040	COG0489	protein tyrosine kinase activity
I3S_RS07045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3S_RS07050	COG1596	polysaccharide export
I3S_RS07055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3S_RS07075	COG1278	Cold shock
I3S_RS07080	COG1278	Cold shock
I3S_RS07100	COG0348	domain, Protein
I3S_RS07105	COG0784	Response regulator, receiver
I3S_RS07105	COG2198	Histidine kinase
I3S_RS07105	COG2205	protein histidine kinase activity
I3S_RS07110	COG0582	viral genome integration into host DNA
I3S_RS07275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3S_RS07325	COG3436	PFAM IS66 Orf2 family protein
I3S_RS07330	COG4372	Transposase
I3S_RS07345	COG3772	lysozyme
I3S_RS07370	COG4220	transposase activity
I3S_RS07545	COG3842	ATPase activity
I3S_RS07560	COG2850	peptidyl-arginine hydroxylation
I3S_RS07565	COG2205	protein histidine kinase activity
I3S_RS07575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3S_RS07595	COG1187	pseudouridine synthase activity
I3S_RS07600	COG0538	isocitrate dehydrogenase activity
I3S_RS07610	COG5562	phage envelope protein
I3S_RS07615	COG0789	Transcriptional regulator
I3S_RS07620	COG2200	EAL domain
I3S_RS07645	COG2200	EAL domain
I3S_RS07705	COG2894	cell division
I3S_RS07735	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3S_RS07750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3S_RS07755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3S_RS07775	COG2719	SpoVR family
I3S_RS07785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3S_RS07795	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3S_RS07810	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I3S_RS07835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS07835	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I3S_RS07835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3S_RS07840	COG1461	Dihydroxyacetone kinase
I3S_RS07845	COG2376	Dihydroxyacetone kinase
I3S_RS07850	COG3284	Transcriptional regulator
I3S_RS07855	COG3468	outer membrane autotransporter barrel domain protein
I3S_RS07870	COG0012	GTP binding
I3S_RS07885	COG0659	secondary active sulfate transmembrane transporter activity
I3S_RS07895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3S_RS07925	COG2890	protein-(glutamine-N5) methyltransferase activity
I3S_RS07930	COG3094	Invasion gene expression up-regulator, SirB
I3S_RS07935	COG2912	Transglutaminase-like superfamily
I3S_RS07960	COG0387	Pfam Sodium calcium exchanger
I3S_RS07965	COG4572	Cation transport regulator
I3S_RS07970	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I3S_RS07975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I3S_RS07980	COG4932	domain protein
I3S_RS07985	COG2197	response regulator
I3S_RS07990	COG3850	Histidine kinase
I3S_RS08000	COG2223	nitrite transmembrane transporter activity
I3S_RS08005	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3S_RS08010	COG1140	nitrate reductase beta subunit
I3S_RS08015	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3S_RS08020	COG2181	nitrate reductase activity
I3S_RS08040	COG0788	formyltetrahydrofolate deformylase activity
I3S_RS08050	COG1752	Esterase of the alpha-beta hydrolase superfamily
I3S_RS08055	COG0745	RESPONSE REGULATOR receiver
I3S_RS08060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3S_RS08070	COG1435	thymidine kinase activity
I3S_RS08075	COG1454	alcohol dehydrogenase
I3S_RS08075	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS08080	COG2095	MarC family integral membrane protein
I3S_RS08090	COG4166	transmembrane transport
I3S_RS08095	COG0601	transmembrane transport
I3S_RS08100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3S_RS08105	COG0444	Belongs to the ABC transporter superfamily
I3S_RS08110	COG4608	Belongs to the ABC transporter superfamily
I3S_RS08130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3S_RS08135	COG2350	Protein conserved in bacteria
I3S_RS08140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I3S_RS08145	COG1607	acyl-coa hydrolase
I3S_RS08165	COG3047	cAMP biosynthetic process
I3S_RS08180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS08220	COG1396	sequence-specific DNA binding
I3S_RS08240	COG1846	Transcriptional regulator
I3S_RS08390	COG3685	Protein conserved in bacteria
I3S_RS08395	COG3685	Protein conserved in bacteria
I3S_RS08400	COG3729	General stress protein
I3S_RS08415	COG0135	phosphoribosylanthranilate isomerase activity
I3S_RS08415	COG0134	indole-3-glycerol-phosphate synthase activity
I3S_RS08420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3S_RS08420	COG0512	Glutamine amidotransferase of anthranilate synthase
I3S_RS08425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3S_RS08435	COG0613	PHP domain protein
I3S_RS08440	COG0009	L-threonylcarbamoyladenylate synthase
I3S_RS08445	COG1187	pseudouridine synthase activity
I3S_RS08450	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I3S_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS08460	COG0616	signal peptide processing
I3S_RS08475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3S_RS08485	COG0583	DNA-binding transcription factor activity
I3S_RS08505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3S_RS08515	COG0671	phosphoesterase, PA-phosphatase related
I3S_RS08520	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I3S_RS08525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I3S_RS08535	COG0023	Translation Initiation Factor
I3S_RS08545	COG1349	DNA-binding transcription factor activity
I3S_RS08555	COG5001	Diguanylate cyclase
I3S_RS08570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3S_RS08570	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3S_RS08575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3S_RS08580	COG2852	Protein conserved in bacteria
I3S_RS08585	COG4172	Belongs to the ABC transporter superfamily
I3S_RS08590	COG4172	Belongs to the ABC transporter superfamily
I3S_RS08595	COG4171	peptide transport system, permease
I3S_RS08600	COG4168	peptide transport system, permease
I3S_RS08605	COG4166	transmembrane transport
I3S_RS08620	COG0531	amino acid
I3S_RS08625	COG0174	glutamine synthetase
I3S_RS08630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3S_RS08635	COG1917	Cupin 2, conserved barrel domain protein
I3S_RS08635	COG1396	sequence-specific DNA binding
I3S_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS08650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3S_RS08655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3S_RS08660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I3S_RS08665	COG1842	Phage shock protein A
I3S_RS08675	COG1983	PspC domain protein
I3S_RS08685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3S_RS08690	COG0366	Alpha amylase catalytic
I3S_RS08700	COG1175	transmembrane transport
I3S_RS08705	COG0395	ABC-type sugar transport system, permease component
I3S_RS08710	COG1063	alcohol dehydrogenase
I3S_RS08715	COG1082	Xylose isomerase domain protein TIM barrel
I3S_RS08720	COG0673	inositol 2-dehydrogenase activity
I3S_RS08725	COG1554	hydrolase, family 65, central catalytic
I3S_RS08730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3S_RS08735	COG3842	ATPase activity
I3S_RS08745	COG1609	Transcriptional regulator
I3S_RS08750	COG3106	COG3106 Predicted ATPase
I3S_RS08760	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I3S_RS08765	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I3S_RS08770	COG4948	Mandelate Racemase Muconate Lactonizing
I3S_RS08775	COG2866	Carboxypeptidase
I3S_RS08780	COG0702	epimerase
I3S_RS08785	COG1073	alpha beta
I3S_RS08790	COG1073	alpha beta
I3S_RS08795	COG0583	DNA-binding transcription factor activity
I3S_RS08800	COG4166	transmembrane transport
I3S_RS08805	COG0668	transmembrane transport
I3S_RS08810	COG3182	Iron-regulated membrane protein
I3S_RS08815	COG0589	response to stress
I3S_RS08820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3S_RS08825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3S_RS08830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3S_RS08840	COG1473	amidohydrolase
I3S_RS08845	COG1473	amidohydrolase
I3S_RS08850	COG0583	DNA-binding transcription factor activity
I3S_RS08860	COG2840	Smr protein MutS2
I3S_RS08865	COG3706	GGDEF domain
I3S_RS08880	COG0513	Belongs to the DEAD box helicase family
I3S_RS08890	COG0582	viral genome integration into host DNA
I3S_RS08915	COG3723	Recombinational DNA repair protein, rece pathway
I3S_RS08920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS08960	COG3756	Protein conserved in bacteria
I3S_RS08965	COG1484	DNA-dependent DNA replication
I3S_RS08970	COG1846	Transcriptional regulator
I3S_RS09070	COG3772	lysozyme
I3S_RS09110	COG0740	serine-type endopeptidase activity
I3S_RS09185	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS09215	COG0477	Major facilitator Superfamily
I3S_RS09230	COG1802	Transcriptional regulator
I3S_RS09235	COG4221	oxidoreductase activity
I3S_RS09245	COG0339	signal peptide processing
I3S_RS09250	COG1546	Belongs to the CinA family
I3S_RS09255	COG3111	PFAM Bacterial OB fold (BOF) protein
I3S_RS09260	COG3706	GGDEF domain
I3S_RS09270	COG2814	Major facilitator Superfamily
I3S_RS09275	COG0697	spore germination
I3S_RS09280	COG2188	Transcriptional regulator
I3S_RS09290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3S_RS09295	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3S_RS09325	COG4977	sequence-specific DNA binding
I3S_RS09330	COG1846	Transcriptional regulator
I3S_RS09350	COG0583	DNA-binding transcription factor activity
I3S_RS09355	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS09360	COG2066	Belongs to the glutaminase family
I3S_RS09375	COG2199	diguanylate cyclase activity
I3S_RS09395	COG3781	membrane
I3S_RS09445	COG2911	Protein conserved in bacteria
I3S_RS09445	COG3210	domain, Protein
I3S_RS09455	COG1396	sequence-specific DNA binding
I3S_RS09460	COG3550	peptidyl-serine autophosphorylation
I3S_RS09475	COG3539	Fimbrial protein
I3S_RS09480	COG3121	Chaperone
I3S_RS09485	COG3188	usher protein
I3S_RS09490	COG3539	Fimbrial protein
I3S_RS09495	COG3539	Fimbrial protein
I3S_RS09500	COG3539	Fimbrial protein
I3S_RS09505	COG0243	molybdopterin cofactor binding
I3S_RS09515	COG2207	Transcriptional regulator
I3S_RS09525	COG0641	radical SAM
I3S_RS09530	COG4178	(ABC) transporter
I3S_RS09535	COG4771	TonB-dependent receptor
I3S_RS09540	COG0612	Peptidase, M16
I3S_RS09545	COG0076	glutamate decarboxylase activity
I3S_RS09550	COG0531	amino acid
I3S_RS09555	COG1649	PFAM Uncharacterised BCR, COG1649
I3S_RS09565	COG2199	diguanylate cyclase activity
I3S_RS09565	COG2200	EAL domain
I3S_RS09565	COG2202	Pas domain
I3S_RS09570	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I3S_RS09575	COG0747	negative chemotaxis
I3S_RS09580	COG0601	transmembrane transport
I3S_RS09585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3S_RS09590	COG0444	Belongs to the ABC transporter superfamily
I3S_RS09595	COG4608	Belongs to the ABC transporter superfamily
I3S_RS09600	COG1764	response to oxidative stress
I3S_RS09630	COG1064	alcohol dehydrogenase
I3S_RS09635	COG3093	addiction module antidote protein HigA
I3S_RS09640	COG2864	formate dehydrogenase
I3S_RS09645	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS09655	COG0697	spore germination
I3S_RS09660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3S_RS09670	COG2223	nitrite transmembrane transporter activity
I3S_RS09675	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3S_RS09680	COG1140	nitrate reductase beta subunit
I3S_RS09685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3S_RS09690	COG2181	nitrate reductase activity
I3S_RS09695	COG0384	phenazine biosynthesis protein PhzF
I3S_RS09700	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I3S_RS09705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3S_RS09715	COG5433	transposase activity
I3S_RS09720	COG5433	transposase activity
I3S_RS09745	COG0625	glutathione transferase activity
I3S_RS09755	COG3391	amine dehydrogenase activity
I3S_RS09765	COG4772	TonB-dependent receptor
I3S_RS09770	COG1802	Transcriptional regulator
I3S_RS09785	COG1247	-acetyltransferase
I3S_RS09790	COG3238	Protein conserved in bacteria
I3S_RS09825	COG1177	transmembrane transport
I3S_RS09830	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3S_RS09835	COG3842	ATPase activity
I3S_RS09840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3S_RS09845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3S_RS09850	COG1598	PFAM Uncharacterised protein family UPF0150
I3S_RS09855	COG1724	mRNA binding
I3S_RS09865	COG0826	peptidase U32
I3S_RS09870	COG1396	sequence-specific DNA binding
I3S_RS09875	COG3135	benzoate transporter
I3S_RS09880	COG0675	Transposase, IS605 OrfB family
I3S_RS09900	COG0500	methyltransferase
I3S_RS09905	COG1275	C4-dicarboxylate transporter malic acid transport protein
I3S_RS09910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3S_RS09915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3S_RS09920	COG2841	Protein conserved in bacteria
I3S_RS09940	COG5383	Protein conserved in bacteria
I3S_RS09945	COG0583	DNA-binding transcription factor activity
I3S_RS09950	COG0840	transmembrane signaling receptor activity
I3S_RS09965	COG3038	cytochrome b561
I3S_RS09970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3S_RS09975	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS09980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3S_RS09985	COG1643	Atp-dependent helicase
I3S_RS09995	COG2453	phosphatase
I3S_RS09995	COG0671	phosphoesterase, PA-phosphatase related
I3S_RS10005	COG4589	Belongs to the CDS family
I3S_RS10010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3S_RS10025	COG0667	Aldo Keto reductase
I3S_RS10030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3S_RS10035	COG3327	negative regulation of DNA-templated transcription, initiation
I3S_RS10040	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I3S_RS10045	COG0183	Belongs to the thiolase family
I3S_RS10050	COG2050	protein possibly involved in aromatic compounds catabolism
I3S_RS10055	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3S_RS10060	COG1024	Enoyl-CoA hydratase
I3S_RS10065	COG1024	Enoyl-CoA hydratase
I3S_RS10070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3S_RS10075	COG2151	metal-sulfur cluster biosynthetic enzyme
I3S_RS10080	COG3396	Phenylacetate-CoA oxygenase
I3S_RS10085	COG3460	Phenylacetate-CoA oxygenase
I3S_RS10090	COG3396	Phenylacetate-CoA oxygenase
I3S_RS10095	COG2030	dehydratase
I3S_RS10095	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS10100	COG3733	amine oxidase
I3S_RS10105	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS10110	COG2207	Transcriptional regulator
I3S_RS10115	COG3784	Protein of unknown function (DUF1318)
I3S_RS10125	COG2911	Protein conserved in bacteria
I3S_RS10130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3S_RS10135	COG3187	Heat shock protein
I3S_RS10140	COG3042	response to heat
I3S_RS10145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3S_RS10145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3S_RS10145	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3S_RS10145	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3S_RS10150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3S_RS10155	COG0589	response to stress
I3S_RS10180	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS10295	COG4220	transposase activity
I3S_RS10330	COG3772	lysozyme
I3S_RS10395	COG1403	HNH endonuclease
I3S_RS10405	COG0305	Participates in initiation and elongation during chromosome replication
I3S_RS10410	COG1484	DNA-dependent DNA replication
I3S_RS10430	COG3646	Phage regulatory protein
I3S_RS10460	COG5532	Uncharacterized conserved protein (DUF2303)
I3S_RS10465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I3S_RS10475	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I3S_RS10525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3S_RS10535	COG0735	belongs to the Fur family
I3S_RS10540	COG3237	CsbD-like
I3S_RS10545	COG0534	Mate efflux family protein
I3S_RS10555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3S_RS10595	COG3842	ATPase activity
I3S_RS10605	COG2182	Extracellular solute-binding protein
I3S_RS10610	COG1175	transmembrane transport
I3S_RS10615	COG3833	ABC-type maltose transport systems, permease component
I3S_RS10620	COG0477	Major facilitator Superfamily
I3S_RS10620	COG2814	Major facilitator Superfamily
I3S_RS10635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3S_RS10665	COG0527	aspartate kinase activity
I3S_RS10675	COG1187	pseudouridine synthase activity
I3S_RS10720	COG1283	sodium-dependent phosphate transmembrane transporter activity
I3S_RS10725	COG1410	methionine synthase
I3S_RS10725	COG0646	methionine synthase
I3S_RS10730	COG1414	Transcriptional regulator
I3S_RS10745	COG2224	Isocitrate lyase
I3S_RS10750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3S_RS10760	COG0456	acetyltransferase
I3S_RS10795	COG0151	Belongs to the GarS family
I3S_RS10800	COG2204	response regulator
I3S_RS10805	COG4191	Histidine kinase
I3S_RS10815	COG3678	ATP-independent chaperone mediated protein folding
I3S_RS10830	COG3068	Protein conserved in bacteria
I3S_RS10870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3S_RS10875	COG2104	thiamine diphosphate biosynthetic process
I3S_RS10885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3S_RS10930	COG0250	Participates in transcription elongation, termination and antitermination
I3S_RS10935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3S_RS10980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I3S_RS10980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I3S_RS11040	COG0583	DNA-binding transcription factor activity
I3S_RS11055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3S_RS11070	COG2194	sulfuric ester hydrolase activity
I3S_RS11075	COG2207	Transcriptional regulator
I3S_RS11080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS11085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3S_RS11090	COG1882	Formate acetyltransferase
I3S_RS11095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS11100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS11105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS11105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS11105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3S_RS11110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3S_RS11115	COG0371	Dehydrogenase
I3S_RS11120	COG3738	Protein conserved in bacteria
I3S_RS11125	COG0697	spore germination
I3S_RS11135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3S_RS11140	COG0460	homoserine dehydrogenase
I3S_RS11140	COG0527	aspartate kinase activity
I3S_RS11145	COG0626	cystathionine gamma-synthase activity
I3S_RS11155	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I3S_RS11165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3S_RS11170	COG1609	Transcriptional regulator
I3S_RS11175	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3S_RS11190	COG1575	Belongs to the MenA family. Type 1 subfamily
I3S_RS11205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3S_RS11215	COG1494	fructose-1,6-bisphosphatase
I3S_RS11225	COG0589	response to stress
I3S_RS11230	COG3691	Protein conserved in bacteria
I3S_RS11235	COG3152	Membrane
I3S_RS11255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I3S_RS11270	COG3678	ATP-independent chaperone mediated protein folding
I3S_RS11275	COG0745	RESPONSE REGULATOR receiver
I3S_RS11280	COG2205	protein histidine kinase activity
I3S_RS11285	COG2258	MOSC domain
I3S_RS11305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3S_RS11345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS11350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS11350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS11355	COG1363	Peptidase, m42
I3S_RS11360	COG3711	transcriptional antiterminator
I3S_RS11360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS11380	COG0243	molybdopterin cofactor binding
I3S_RS11380	COG3383	formate dehydrogenase (NAD+) activity
I3S_RS11385	COG0243	molybdopterin cofactor binding
I3S_RS11385	COG3383	formate dehydrogenase (NAD+) activity
I3S_RS11390	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS11395	COG2864	formate dehydrogenase
I3S_RS11405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3S_RS11410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3S_RS11425	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I3S_RS11450	COG0456	acetyltransferase
I3S_RS11465	COG1011	Hydrolase
I3S_RS11475	COG0477	Major facilitator Superfamily
I3S_RS11485	COG1063	alcohol dehydrogenase
I3S_RS11490	COG3684	Belongs to the aldolase LacD family
I3S_RS11500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS11505	COG1349	DNA-binding transcription factor activity
I3S_RS11510	COG1217	gtp-binding protein TYPA
I3S_RS11520	COG0174	glutamine synthetase
I3S_RS11525	COG3852	Histidine kinase
I3S_RS11530	COG2204	response regulator
I3S_RS11540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3S_RS11555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3S_RS11555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3S_RS11565	COG0204	Acyl-transferase
I3S_RS11570	COG5339	Protein conserved in bacteria
I3S_RS11575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3S_RS11580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3S_RS11585	COG3084	Protein conserved in bacteria
I3S_RS11590	COG0746	molybdenum cofactor guanylyltransferase activity
I3S_RS11595	COG1763	Mo-molybdopterin cofactor biosynthetic process
I3S_RS11625	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I3S_RS11630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3S_RS11635	COG1739	Uncharacterized protein family UPF0029
I3S_RS11655	COG0543	2 iron, 2 sulfur cluster binding
I3S_RS11660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3S_RS11665	COG0250	Participates in transcription elongation, termination and antitermination
I3S_RS11675	COG0805	protein transport
I3S_RS11680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3S_RS11685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3S_RS11695	COG3165	ubiquinone biosynthetic process from chorismate
I3S_RS11705	COG1322	Protein conserved in bacteria
I3S_RS11710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I3S_RS11715	COG0412	Dienelactone hydrolase
I3S_RS11720	COG3157	Type VI secretion system effector, Hcp
I3S_RS11740	COG0583	DNA-binding transcription factor activity
I3S_RS11745	COG0697	spore germination
I3S_RS11750	COG0561	phosphatase activity
I3S_RS11755	COG2267	carboxylic ester hydrolase activity
I3S_RS11760	COG1280	lysine exporter protein (LysE YggA)
I3S_RS11765	COG1280	lysine exporter protein (LysE YggA)
I3S_RS11770	COG0514	ATP-dependent DNA helicase (RecQ)
I3S_RS11775	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I3S_RS11780	COG2050	protein possibly involved in aromatic compounds catabolism
I3S_RS11785	COG2962	Rard protein
I3S_RS11815	COG0598	Magnesium transport protein CorA
I3S_RS11820	COG3698	Phosphodiester glycosidase
I3S_RS11825	COG0210	DNA helicase
I3S_RS11830	COG1011	Hydrolase
I3S_RS11840	COG3159	Protein conserved in bacteria
I3S_RS11850	COG5567	small periplasmic lipoprotein
I3S_RS11860	COG3072	Adenylate cyclase
I3S_RS11875	COG1587	Uroporphyrinogen-III synthase
I3S_RS11880	COG2959	enzyme of heme biosynthesis
I3S_RS11885	COG3071	HemY protein
I3S_RS11890	COG0641	radical SAM
I3S_RS11915	COG1113	amino acid transport
I3S_RS11935	COG2244	polysaccharide biosynthetic process
I3S_RS11940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3S_RS11945	COG0456	acetyltransferase
I3S_RS11950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3S_RS11955	COG1088	dTDP-glucose 4,6-dehydratase activity
I3S_RS11960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I3S_RS11965	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3S_RS11970	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3S_RS11975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3S_RS11985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I3S_RS11995	COG3118	belongs to the thioredoxin family
I3S_RS12015	COG0210	DNA helicase
I3S_RS12020	COG3692	DNA binding
I3S_RS12025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3S_RS12035	COG0583	DNA-binding transcription factor activity
I3S_RS12040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3S_RS12050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3S_RS12055	COG3978	acetolactate synthase activity
I3S_RS12085	COG3085	chromosome segregation
I3S_RS12125	COG2186	Transcriptional regulator
I3S_RS12130	COG0477	Major facilitator Superfamily
I3S_RS12135	COG1609	Transcriptional regulator
I3S_RS12140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS12145	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS12150	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS12155	COG1129	ABC transporter
I3S_RS12185	COG1522	sequence-specific DNA binding
I3S_RS12190	COG0716	FMN binding
I3S_RS12205	COG3312	ion transport
I3S_RS12260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3S_RS12285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3S_RS12290	COG0573	inorganic phosphate transmembrane transporter activity
I3S_RS12295	COG0581	inorganic phosphate transmembrane transporter activity
I3S_RS12300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3S_RS12305	COG0704	Plays a role in the regulation of phosphate uptake
I3S_RS12310	COG3711	transcriptional antiterminator
I3S_RS12315	COG1263	PTS System
I3S_RS12315	COG2190	(PTS) system
I3S_RS12315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS12320	COG2723	6-phospho-beta-galactosidase activity
I3S_RS12330	COG2382	esterase
I3S_RS12335	COG0363	glucosamine-6-phosphate deaminase activity
I3S_RS12345	COG4372	Transposase
I3S_RS12350	COG3436	PFAM IS66 Orf2 family protein
I3S_RS12370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3S_RS12375	COG2252	PERMEase
I3S_RS12380	COG0431	NADPH-dependent FMN reductase
I3S_RS12385	COG2091	lysine biosynthetic process via aminoadipic acid
I3S_RS12400	COG0814	amino acid
I3S_RS12450	COG0592	DNA-directed DNA polymerase activity
I3S_RS12460	COG0187	DNA topoisomerase II activity
I3S_RS12465	COG3753	Protein conserved in bacteria
I3S_RS12470	COG0561	phosphatase activity
I3S_RS12480	COG2186	Transcriptional regulator
I3S_RS12485	COG3734	2-keto-3-deoxy-galactonokinase
I3S_RS12490	COG0800	Aldolase
I3S_RS12500	COG2271	Major facilitator Superfamily
I3S_RS12510	COG0823	Involved in the tonB-independent uptake of proteins
I3S_RS12515	COG5645	(Lipo)protein
I3S_RS12535	COG2188	Transcriptional regulator
I3S_RS12550	COG2207	Transcriptional regulator
I3S_RS12555	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3S_RS12560	COG3119	arylsulfatase activity
I3S_RS12570	COG2149	membrane
I3S_RS12580	COG0641	radical SAM
I3S_RS12585	COG2814	Major facilitator Superfamily
I3S_RS12620	COG0028	Belongs to the TPP enzyme family
I3S_RS12625	COG0440	acetolactate synthase activity
I3S_RS12630	COG2197	response regulator
I3S_RS12635	COG3851	Histidine kinase
I3S_RS12640	COG2271	Major facilitator Superfamily
I3S_RS12645	COG2271	Major facilitator Superfamily
I3S_RS12655	COG2252	PERMEase
I3S_RS12685	COG1464	Belongs to the NlpA lipoprotein family
I3S_RS12690	COG0697	spore germination
I3S_RS12695	COG2814	Major facilitator Superfamily
I3S_RS12710	COG2211	Major facilitator Superfamily
I3S_RS12715	COG1501	Belongs to the glycosyl hydrolase 31 family
I3S_RS12720	COG2982	Protein involved in outer membrane biogenesis
I3S_RS12725	COG2233	PERMEase
I3S_RS12730	COG0786	glutamate:sodium symporter activity
I3S_RS12740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3S_RS12745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3S_RS12750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3S_RS12760	COG0194	GDP metabolic process
I3S_RS12770	COG2860	membrane
I3S_RS12775	COG3645	SOS response
I3S_RS12780	COG1561	YicC-like family, N-terminal region
I3S_RS12810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3S_RS12840	COG1519	Transferase
I3S_RS12845	COG0859	PFAM glycosyl transferase family 9
I3S_RS12850	COG0438	transferase activity, transferring glycosyl groups
I3S_RS12855	COG0515	serine threonine protein kinase
I3S_RS12870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3S_RS12875	COG1442	glycosyl transferase family 8
I3S_RS12880	COG1216	Glycosyl transferase, family 2
I3S_RS12885	COG3307	-O-antigen
I3S_RS12890	COG0859	PFAM glycosyl transferase family 9
I3S_RS12895	COG0859	PFAM glycosyl transferase family 9
I3S_RS12905	COG0156	8-amino-7-oxononanoate synthase activity
I3S_RS12915	COG1216	Glycosyl transferase, family 2
I3S_RS12920	COG2861	carbohydrate metabolic process
I3S_RS12925	COG4942	peptidase
I3S_RS12940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3S_RS12945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3S_RS12960	COG1045	serine acetyltransferase
I3S_RS12965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3S_RS12975	COG2186	Transcriptional regulator
I3S_RS12980	COG1620	l-lactate permease
I3S_RS12990	COG5295	Hep Hag repeat protein
I3S_RS13015	COG3722	fumarate hydratase activity
I3S_RS13025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS13025	COG2213	PTS system mannitol-specific
I3S_RS13035	COG1566	PFAM secretion protein HlyD family protein
I3S_RS13055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3S_RS13060	COG3209	COG3209 Rhs family protein
I3S_RS13070	COG3209	COG3209 Rhs family protein
I3S_RS13075	COG0625	glutathione transferase activity
I3S_RS13085	COG3276	selenocysteine insertion sequence binding
I3S_RS13090	COG1454	alcohol dehydrogenase
I3S_RS13095	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS13110	COG1566	PFAM secretion protein HlyD family protein
I3S_RS13115	COG0583	DNA-binding transcription factor activity
I3S_RS13120	COG3713	MltA-interacting MipA family protein
I3S_RS13130	COG0235	Class ii aldolase
I3S_RS13135	COG3623	hexulose-6-phosphate isomerase
I3S_RS13140	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3S_RS13145	COG1070	Carbohydrate kinase
I3S_RS13150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3S_RS13155	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I3S_RS13160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3S_RS13165	COG2731	YhcH YjgK YiaL family protein
I3S_RS13175	COG1414	Transcriptional regulator
I3S_RS13180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS13185	COG3977	Valine--pyruvate aminotransferase
I3S_RS13190	COG0366	Alpha amylase catalytic
I3S_RS13195	COG2992	FlgJ-related protein
I3S_RS13200	COG2207	Transcriptional regulator
I3S_RS13200	COG1609	Transcriptional regulator
I3S_RS13205	COG4214	carbohydrate transport
I3S_RS13215	COG4213	ABC transporter substrate-binding protein
I3S_RS13225	COG1070	Carbohydrate kinase
I3S_RS13230	COG4682	membrane
I3S_RS13235	COG4682	membrane
I3S_RS13240	COG3274	enterobacterial common antigen metabolic process
I3S_RS13265	COG1278	Cold shock
I3S_RS13270	COG2944	sequence-specific DNA binding
I3S_RS13285	COG2885	chlorophyll binding
I3S_RS13290	COG0243	molybdopterin cofactor binding
I3S_RS13295	COG0456	acetyltransferase
I3S_RS13300	COG2818	Glycosylase
I3S_RS13305	COG5571	outer membrane autotransporter
I3S_RS13315	COG2223	nitrite transmembrane transporter activity
I3S_RS13320	COG2194	sulfuric ester hydrolase activity
I3S_RS13335	COG0747	negative chemotaxis
I3S_RS13340	COG0601	transmembrane transport
I3S_RS13345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3S_RS13350	COG0444	Belongs to the ABC transporter superfamily
I3S_RS13355	COG4608	Belongs to the ABC transporter superfamily
I3S_RS13360	COG0814	amino acid
I3S_RS13390	COG2194	sulfuric ester hydrolase activity
I3S_RS13415	COG1215	transferase activity, transferring glycosyl groups
I3S_RS13420	COG1215	transferase activity, transferring glycosyl groups
I3S_RS13425	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I3S_RS13430	COG3118	belongs to the thioredoxin family
I3S_RS13430	COG0457	Tetratricopeptide repeat
I3S_RS13435	COG2199	diguanylate cyclase activity
I3S_RS13435	COG2200	EAL domain
I3S_RS13450	COG0612	Peptidase, M16
I3S_RS13465	COG2200	EAL domain
I3S_RS13470	COG2982	Protein involved in outer membrane biogenesis
I3S_RS13475	COG0477	Major facilitator Superfamily
I3S_RS13480	COG1295	ribonuclease BN
I3S_RS13485	COG0583	DNA-binding transcription factor activity
I3S_RS13490	COG2197	response regulator
I3S_RS13500	COG1858	cytochrome C peroxidase
I3S_RS13505	COG0076	glutamate decarboxylase activity
I3S_RS13515	COG2207	Transcriptional regulator
I3S_RS13525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3S_RS13530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS13540	COG2771	luxR family
I3S_RS13545	COG3247	response to pH
I3S_RS13560	COG1285	pathogenesis
I3S_RS13565	COG2197	response regulator
I3S_RS13575	COG3065	identical protein binding
I3S_RS13595	COG1393	Belongs to the ArsC family
I3S_RS13600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3S_RS13605	COG0640	Transcriptional regulator
I3S_RS13620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3S_RS13625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I3S_RS13630	COG0339	signal peptide processing
I3S_RS13640	COG3104	oligopeptide transport
I3S_RS13650	COG0589	response to stress
I3S_RS13660	COG0306	phosphate transporter
I3S_RS13665	COG2081	HI0933 family
I3S_RS13690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS13695	COG0842	Transport permease protein
I3S_RS13695	COG1129	ABC transporter
I3S_RS13700	COG0842	Transport permease protein
I3S_RS13725	COG0444	Belongs to the ABC transporter superfamily
I3S_RS13730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3S_RS13735	COG0601	transmembrane transport
I3S_RS13740	COG0747	negative chemotaxis
I3S_RS13745	COG2091	lysine biosynthetic process via aminoadipic acid
I3S_RS13750	COG0628	permease
I3S_RS13765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I3S_RS13780	COG3714	YhhN family
I3S_RS13790	COG3776	membrane
I3S_RS13795	COG0742	ribosomal rna small subunit methyltransferase
I3S_RS13800	COG0552	protein localization to endoplasmic reticulum
I3S_RS13805	COG2884	Cell division ATP-binding protein ftsE
I3S_RS13810	COG2177	Part of the ABC transporter FtsEX involved in
I3S_RS13815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3S_RS13820	COG0683	leucine binding
I3S_RS13825	COG0456	acetyltransferase
I3S_RS13830	COG0683	leucine binding
I3S_RS13835	COG0559	Belongs to the binding-protein-dependent transport system permease family
I3S_RS13840	COG4177	L-phenylalanine transmembrane transporter activity
I3S_RS13845	COG0411	ABC transporter
I3S_RS13850	COG0410	ABC transporter
I3S_RS13855	COG1653	transport
I3S_RS13860	COG1175	transmembrane transport
I3S_RS13865	COG0395	ABC-type sugar transport system, permease component
I3S_RS13870	COG3842	ATPase activity
I3S_RS13875	COG0584	glycerophosphoryl diester phosphodiesterase
I3S_RS13885	COG0405	Gamma-glutamyltransferase
I3S_RS13905	COG3157	Type VI secretion system effector, Hcp
I3S_RS13910	COG1247	-acetyltransferase
I3S_RS13920	COG0673	inositol 2-dehydrogenase activity
I3S_RS13925	COG1741	Belongs to the pirin family
I3S_RS13930	COG1609	Transcriptional regulator
I3S_RS13935	COG3265	gluconokinase activity
I3S_RS13940	COG2610	gluconate transmembrane transporter activity
I3S_RS13945	COG2095	MarC family integral membrane protein
I3S_RS13950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3S_RS13975	COG0058	SHG alpha-glucan phosphorylase activity
I3S_RS14000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3S_RS14015	COG1349	DNA-binding transcription factor activity
I3S_RS14020	COG4650	regulator
I3S_RS14025	COG1690	Belongs to the RtcB family
I3S_RS14040	COG0058	SHG alpha-glucan phosphorylase activity
I3S_RS14045	COG1640	4-alpha-glucanotransferase
I3S_RS14050	COG2610	gluconate transmembrane transporter activity
I3S_RS14070	COG5464	transposase or invertase
I3S_RS14085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I3S_RS14090	COG1918	ferrous iron import across plasma membrane
I3S_RS14100	COG2183	response to ionizing radiation
I3S_RS14105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3S_RS14135	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3S_RS14145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I3S_RS14150	COG1011	Hydrolase
I3S_RS14160	COG0494	nUDIX hydrolase
I3S_RS14165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3S_RS14170	COG4972	Pilus assembly protein
I3S_RS14175	COG3166	PFAM Fimbrial assembly family protein
I3S_RS14190	COG4796	Type ii and iii secretion system protein
I3S_RS14210	COG3266	domain, Protein
I3S_RS14215	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I3S_RS14220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3S_RS14230	COG0180	Tryptophanyl-tRNA synthetase
I3S_RS14235	COG2188	Transcriptional regulator
I3S_RS14245	COG3457	Alanine racemase
I3S_RS14250	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I3S_RS14255	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3S_RS14275	COG2188	Transcriptional regulator
I3S_RS14285	COG1082	Xylose isomerase domain protein TIM barrel
I3S_RS14295	COG2222	sugar isomerase
I3S_RS14300	COG0531	amino acid
I3S_RS14325	COG2116	formate transmembrane transporter activity
I3S_RS14330	COG2146	nitrite reductase [NAD(P)H] activity
I3S_RS14335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3S_RS14345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3S_RS14355	COG2184	nucleotidyltransferase activity
I3S_RS14360	COG0512	Glutamine amidotransferase of anthranilate synthase
I3S_RS14365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3S_RS14370	COG1289	transmembrane transporter activity
I3S_RS14375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3S_RS14385	COG1765	OsmC-like protein
I3S_RS14390	COG3954	Phosphoribulokinase
I3S_RS14400	COG0429	hydrolase of the alpha beta-hydrolase fold
I3S_RS14405	COG0488	(ABC) transporter
I3S_RS14425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I3S_RS14430	COG1047	Peptidyl-prolyl cis-trans
I3S_RS14440	COG0545	Peptidyl-prolyl cis-trans isomerase
I3S_RS14445	COG2964	Protein conserved in bacteria
I3S_RS14525	COG0089	rRNA binding
I3S_RS14615	COG0201	protein transport
I3S_RS14655	COG0789	Transcriptional regulator
I3S_RS14660	COG3036	rescue of stalled ribosome
I3S_RS14670	COG0569	domain protein
I3S_RS14690	COG0758	DNA mediated transformation
I3S_RS14700	COG0551	DNA topoisomerase type I activity
I3S_RS14720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3S_RS14760	COG1126	abc transporter atp-binding protein
I3S_RS14765	COG0765	amino acid transport
I3S_RS14770	COG4597	amino acid ABC transporter
I3S_RS14775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS14790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3S_RS14795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3S_RS14805	COG1309	transcriptional regulator
I3S_RS14815	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I3S_RS14825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3S_RS14835	COG4145	pantothenate transmembrane transporter activity
I3S_RS14840	COG3924	membrane
I3S_RS14845	COG0439	Biotin carboxylase
I3S_RS14850	COG0511	ligase activity, forming carbon-carbon bonds
I3S_RS14865	COG0604	alcohol dehydrogenase
I3S_RS14885	COG1077	Cell shape determining protein MreB Mrl
I3S_RS14890	COG1792	Involved in formation and maintenance of cell shape
I3S_RS14895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I3S_RS14905	COG1530	ribonuclease E activity
I3S_RS14910	COG3164	Protein of unknown function
I3S_RS14915	COG0312	modulator of DNA gyrase
I3S_RS14920	COG0583	DNA-binding transcription factor activity
I3S_RS14940	COG2732	(Barnase) inhibitor
I3S_RS14960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3S_RS14965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3S_RS14970	COG3105	Protein conserved in bacteria
I3S_RS14975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I3S_RS14995	COG0625	glutathione transferase activity
I3S_RS15000	COG2969	positive regulation of protein catabolic process
I3S_RS15005	COG3069	C4-dicarboxylate transmembrane transporter activity
I3S_RS15040	COG2731	YhcH YjgK YiaL family protein
I3S_RS15045	COG4804	nuclease activity
I3S_RS15050	COG0493	'glutamate synthase
I3S_RS15055	COG0070	glutamate synthase
I3S_RS15055	COG0069	glutamate synthase activity
I3S_RS15055	COG0067	glutamate synthase
I3S_RS15070	COG1242	4 iron, 4 sulfur cluster binding
I3S_RS15075	COG0784	Response regulator, receiver
I3S_RS15075	COG2198	Histidine kinase
I3S_RS15075	COG5002	protein histidine kinase activity
I3S_RS15080	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I3S_RS15090	COG0515	serine threonine protein kinase
I3S_RS15095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS15110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3S_RS15115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I3S_RS15120	COG1137	ATPase activity
I3S_RS15125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I3S_RS15130	COG3117	lipopolysaccharide transmembrane transporter activity
I3S_RS15135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I3S_RS15140	COG0517	IMP dehydrogenase activity
I3S_RS15140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3S_RS15145	COG0530	calcium, potassium:sodium antiporter activity
I3S_RS15150	COG1127	ABC transporter
I3S_RS15155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3S_RS15160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3S_RS15165	COG2854	intermembrane phospholipid transfer
I3S_RS15170	COG3113	response to antibiotic
I3S_RS15175	COG5007	Belongs to the BolA IbaG family
I3S_RS15185	COG3423	Transcriptional regulator
I3S_RS15190	COG0142	geranyltranstransferase activity
I3S_RS15205	COG0697	spore germination
I3S_RS15215	COG2027	D-alanyl-D-alanine carboxypeptidase
I3S_RS15220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3S_RS15225	COG1534	Rna-binding protein
I3S_RS15235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3S_RS15240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3S_RS15250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3S_RS15260	COG2194	sulfuric ester hydrolase activity
I3S_RS15280	COG0195	Participates in both transcription termination and antitermination
I3S_RS15320	COG0513	Belongs to the DEAD box helicase family
I3S_RS15325	COG0814	amino acid
I3S_RS15330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3S_RS15335	COG0826	peptidase U32
I3S_RS15340	COG0826	peptidase U32
I3S_RS15345	COG3154	lipid carrier protein
I3S_RS15350	COG3153	acetyltransferase
I3S_RS15365	COG0693	protein deglycase activity
I3S_RS15370	COG0702	epimerase
I3S_RS15375	COG0701	Predicted permease
I3S_RS15380	COG2823	Periplasmic or secreted lipoprotein
I3S_RS15400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I3S_RS15405	COG3539	Fimbrial protein
I3S_RS15410	COG3188	usher protein
I3S_RS15415	COG3121	Chaperone
I3S_RS15420	COG3539	Fimbrial protein
I3S_RS15425	COG0363	glucosamine-6-phosphate deaminase activity
I3S_RS15430	COG3716	PTS system mannose fructose sorbose family IID component
I3S_RS15435	COG3715	PTS system
I3S_RS15440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS15450	COG2222	sugar isomerase
I3S_RS15455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3S_RS15460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS15465	COG3716	PTS system mannose fructose sorbose family IID component
I3S_RS15475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS15490	COG1349	DNA-binding transcription factor activity
I3S_RS15500	COG2002	toxin-antitoxin pair type II binding
I3S_RS15505	COG2721	sulfolactate sulfo-lyase activity
I3S_RS15510	COG2271	Major facilitator Superfamily
I3S_RS15520	COG2084	Dehydrogenase
I3S_RS15525	COG1929	Belongs to the glycerate kinase type-1 family
I3S_RS15550	COG0583	DNA-binding transcription factor activity
I3S_RS15560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3S_RS15570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3S_RS15575	COG1882	Formate acetyltransferase
I3S_RS15580	COG0251	oxidation-reduction process
I3S_RS15585	COG1760	l-serine dehydratase
I3S_RS15595	COG0814	amino acid
I3S_RS15610	COG1741	Belongs to the pirin family
I3S_RS15615	COG0583	DNA-binding transcription factor activity
I3S_RS15625	COG3152	Membrane
I3S_RS15630	COG3152	Membrane
I3S_RS15635	COG0435	Glutathione S-transferase
I3S_RS15640	COG2259	Doxx family
I3S_RS15650	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I3S_RS15655	COG4575	ribosome binding
I3S_RS15660	COG1422	Protein of unknown function (DUF1090)
I3S_RS15670	COG0586	Pfam SNARE associated Golgi protein
I3S_RS15675	COG2186	Transcriptional regulator
I3S_RS15705	COG2271	Major facilitator Superfamily
I3S_RS15715	COG2721	sulfolactate sulfo-lyase activity
I3S_RS15730	COG0861	Integral membrane protein TerC family
I3S_RS15735	COG0673	inositol 2-dehydrogenase activity
I3S_RS15740	COG2949	membrane
I3S_RS15745	COG1451	nucleotide metabolic process
I3S_RS15760	COG4680	protein conserved in bacteria
I3S_RS15765	COG5499	transcription regulator containing HTH domain
I3S_RS15770	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3S_RS15770	COG1902	pentaerythritol trinitrate reductase activity
I3S_RS15775	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I3S_RS15775	COG3408	Glycogen debranching enzyme
I3S_RS15785	COG0531	amino acid
I3S_RS15790	COG2731	YhcH YjgK YiaL family protein
I3S_RS15795	COG3250	beta-galactosidase activity
I3S_RS15800	COG1609	Transcriptional regulator
I3S_RS15810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3S_RS15825	COG0840	transmembrane signaling receptor activity
I3S_RS15830	COG1695	Transcriptional regulator
I3S_RS15840	COG2375	cellular response to nickel ion
I3S_RS15865	COG4983	Phage plasmid primase, P4 family domain protein
I3S_RS15885	COG4372	Transposase
I3S_RS15890	COG3436	PFAM IS66 Orf2 family protein
I3S_RS15895	COG4372	Transposase
I3S_RS15900	COG3436	PFAM IS66 Orf2 family protein
I3S_RS15955	COG0804	urea catabolic process
I3S_RS15995	COG2194	sulfuric ester hydrolase activity
I3S_RS16000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3S_RS16025	COG0254	rRNA binding
I3S_RS16070	COG4372	Transposase
I3S_RS16105	COG1358	cellular component organization or biogenesis
I3S_RS16170	COG3436	PFAM IS66 Orf2 family protein
I3S_RS16175	COG4372	Transposase
I3S_RS16265	COG2003	Belongs to the UPF0758 family
I3S_RS16310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3S_RS16320	COG0358	DNA primase activity
I3S_RS16325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I3S_RS16340	COG0471	metal ion transport
I3S_RS16345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3S_RS16350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3S_RS16360	COG0583	DNA-binding transcription factor activity
I3S_RS16370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3S_RS16385	COG4991	sh3 domain protein
I3S_RS16395	COG3025	triphosphatase activity
I3S_RS16425	COG2268	Band 7 protein
I3S_RS16430	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3S_RS16440	COG3539	Fimbrial protein
I3S_RS16450	COG3188	usher protein
I3S_RS16455	COG3539	Fimbrial protein
I3S_RS16460	COG2960	long-chain fatty acid transporting porin activity
I3S_RS16480	COG3384	dioxygenase
I3S_RS16485	COG0754	glutathionylspermidine amidase activity
I3S_RS16500	COG1538	Outer membrane efflux protein
I3S_RS16505	COG0494	nUDIX hydrolase
I3S_RS16510	COG3151	Protein conserved in bacteria
I3S_RS16515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3S_RS16520	COG3150	esterase
I3S_RS16525	COG0187	DNA topoisomerase II activity
I3S_RS16530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I3S_RS16535	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3S_RS16550	COG0642	Histidine kinase
I3S_RS16555	COG0745	RESPONSE REGULATOR receiver
I3S_RS16560	COG3111	PFAM Bacterial OB fold (BOF) protein
I3S_RS16565	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3S_RS16575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3S_RS16580	COG0204	Acyl-transferase
I3S_RS16585	COG2132	Multicopper oxidase
I3S_RS16590	COG1032	radical SAM domain protein
I3S_RS16595	COG4238	major outer membrane lipoprotein
I3S_RS16610	COG0656	L-ascorbic acid biosynthetic process
I3S_RS16615	COG1979	alcohol dehydrogenase
I3S_RS16620	COG2207	Transcriptional regulator
I3S_RS16625	COG0586	Pfam SNARE associated Golgi protein
I3S_RS16630	COG0626	cystathionine gamma-synthase activity
I3S_RS16640	COG0811	peptide transport
I3S_RS16645	COG0848	biopolymer transport protein
I3S_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS16660	COG0667	Aldo Keto reductase
I3S_RS16680	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I3S_RS16685	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS16690	COG5557	Pfam Polysulphide reductase, NrfD
I3S_RS16695	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I3S_RS16700	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3S_RS16705	COG1773	rubredoxin
I3S_RS16715	COG0298	carbon dioxide binding
I3S_RS16720	COG0625	glutathione transferase activity
I3S_RS16725	COG0754	glutathionylspermidine amidase activity
I3S_RS16730	COG0306	phosphate transporter
I3S_RS16735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3S_RS16740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3S_RS16745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3S_RS16750	COG2244	polysaccharide biosynthetic process
I3S_RS16760	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3S_RS16765	COG0795	lipopolysaccharide-transporting ATPase activity
I3S_RS16805	COG0318	PFAM AMP-dependent synthetase and ligase
I3S_RS16815	COG0456	acetyltransferase
I3S_RS16820	COG2186	Transcriptional regulator
I3S_RS16825	COG0277	FAD linked oxidase domain protein
I3S_RS16830	COG0277	FAD linked oxidase domain protein
I3S_RS16835	COG0247	lactate metabolic process
I3S_RS16840	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I3S_RS16845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3S_RS16850	COG1620	l-lactate permease
I3S_RS16865	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I3S_RS16885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3S_RS16890	COG1459	type II secretion system
I3S_RS16895	COG2165	general secretion pathway protein
I3S_RS16925	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I3S_RS16960	COG2003	Belongs to the UPF0758 family
I3S_RS17240	COG3436	PFAM IS66 Orf2 family protein
I3S_RS17245	COG4372	Transposase
I3S_RS17275	COG2003	Belongs to the UPF0758 family
I3S_RS17285	COG3436	PFAM IS66 Orf2 family protein
I3S_RS17310	COG4372	Transposase
I3S_RS17315	COG3436	PFAM IS66 Orf2 family protein
I3S_RS17325	COG4372	Transposase
I3S_RS17330	COG0582	viral genome integration into host DNA
I3S_RS17340	COG1811	Na channel or pump
I3S_RS17350	COG1982	Orn Lys Arg decarboxylase major
I3S_RS17355	COG2211	Major facilitator Superfamily
I3S_RS17370	COG1194	a g-specific adenine glycosylase
I3S_RS17385	COG3171	Protein conserved in bacteria
I3S_RS17395	COG0252	asparaginase activity
I3S_RS17410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3S_RS17415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3S_RS17420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3S_RS17435	COG0762	integral membrane protein
I3S_RS17440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3S_RS17445	COG2805	Type II/IV secretion system protein
I3S_RS17460	COG0189	ligase activity
I3S_RS17465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3S_RS17470	COG2356	endonuclease I
I3S_RS17480	COG2814	Major facilitator Superfamily
I3S_RS17505	COG1166	arginine decarboxylase activity
I3S_RS17520	COG0501	Belongs to the peptidase M48B family
I3S_RS17525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3S_RS17530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS17535	COG2213	PTS system mannitol-specific
I3S_RS17540	COG1063	alcohol dehydrogenase
I3S_RS17545	COG1494	fructose-1,6-bisphosphatase
I3S_RS17555	COG1072	(Pantothenic acid kinase))
I3S_RS17560	COG1122	ATPase activity
I3S_RS17565	COG1122	ATPase activity
I3S_RS17600	COG0191	fructose-bisphosphate aldolase activity
I3S_RS17610	COG0668	transmembrane transport
I3S_RS17620	COG2968	Membrane
I3S_RS17625	COG0583	DNA-binding transcription factor activity
I3S_RS17630	COG0427	acetyl-CoA hydrolase
I3S_RS17635	COG1024	Enoyl-CoA hydratase
I3S_RS17640	COG1703	isobutyryl-CoA mutase activity
I3S_RS17645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3S_RS17645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3S_RS17665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3S_RS17685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3S_RS17710	COG0006	proline dipeptidase activity
I3S_RS17715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3S_RS17720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3S_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS17745	COG2723	6-phospho-beta-galactosidase activity
I3S_RS17755	COG1272	protein, Hemolysin III
I3S_RS17765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I3S_RS17775	COG0716	FMN binding
I3S_RS17780	COG4974	Belongs to the 'phage' integrase family
I3S_RS17785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3S_RS17790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I3S_RS17815	COG2233	PERMEase
I3S_RS17825	COG0493	'glutamate synthase
I3S_RS17825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS17830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS17835	COG2252	PERMEase
I3S_RS17840	COG0402	S-adenosylhomocysteine deaminase activity
I3S_RS17845	COG2233	PERMEase
I3S_RS17850	COG2080	2 iron, 2 sulfur cluster binding
I3S_RS17850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3S_RS17855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3S_RS17860	COG0402	S-adenosylhomocysteine deaminase activity
I3S_RS17865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS17865	COG0493	'glutamate synthase
I3S_RS17870	COG2068	MobA-Related Protein
I3S_RS17875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3S_RS17880	COG3608	succinylglutamate desuccinylase aspartoacylase
I3S_RS17880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3S_RS17885	COG0549	Belongs to the carbamate kinase family
I3S_RS17895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3S_RS17900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3S_RS17905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3S_RS17910	COG3829	transcription factor binding
I3S_RS17915	COG2080	2 iron, 2 sulfur cluster binding
I3S_RS17920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3S_RS17925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3S_RS17935	COG4942	peptidase
I3S_RS17955	COG0814	amino acid
I3S_RS17960	COG0183	Belongs to the thiolase family
I3S_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS17975	COG2814	Major facilitator Superfamily
I3S_RS17980	COG1794	racemase activity, acting on amino acids and derivatives
I3S_RS17985	COG0583	DNA-binding transcription factor activity
I3S_RS17995	COG1609	Transcriptional regulator
I3S_RS18010	COG0667	Aldo Keto reductase
I3S_RS18020	COG0861	Integral membrane protein TerC family
I3S_RS18035	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I3S_RS18050	COG2165	general secretion pathway protein
I3S_RS18055	COG4795	General secretion pathway protein
I3S_RS18065	COG4967	type IV pilus modification protein PilV
I3S_RS18070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3S_RS18080	COG1074	ATP-dependent DNA helicase activity
I3S_RS18085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3S_RS18090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3S_RS18090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3S_RS18100	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3S_RS18125	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I3S_RS18130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I3S_RS18135	COG2166	iron-sulfur cluster assembly
I3S_RS18140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3S_RS18150	COG0583	DNA-binding transcription factor activity
I3S_RS18155	COG2363	Small membrane protein
I3S_RS18165	COG1349	DNA-binding transcription factor activity
I3S_RS18175	COG1070	Carbohydrate kinase
I3S_RS18185	COG0738	Major facilitator superfamily
I3S_RS18190	COG0235	Class ii aldolase
I3S_RS18195	COG1454	alcohol dehydrogenase
I3S_RS18205	COG1760	l-serine dehydratase
I3S_RS18210	COG0814	amino acid
I3S_RS18215	COG1611	Belongs to the LOG family
I3S_RS18230	COG3098	single-species biofilm formation
I3S_RS18235	COG0564	pseudouridine synthase activity
I3S_RS18240	COG0716	FMN binding
I3S_RS18245	COG2271	Major facilitator Superfamily
I3S_RS18250	COG4948	Mandelate Racemase Muconate Lactonizing
I3S_RS18255	COG4948	Mandelate Racemase Muconate Lactonizing
I3S_RS18260	COG2205	protein histidine kinase activity
I3S_RS18260	COG3850	Histidine kinase
I3S_RS18260	COG4999	Histidine kinase
I3S_RS18260	COG3437	response regulator, receiver
I3S_RS18270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3S_RS18275	COG2336	PFAM SpoVT AbrB
I3S_RS18280	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3S_RS18285	COG3956	TIGRFAM MazG family protein
I3S_RS18310	COG0602	queuosine metabolic process
I3S_RS18315	COG1070	Carbohydrate kinase
I3S_RS18320	COG2223	nitrite transmembrane transporter activity
I3S_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS18330	COG0277	FAD linked oxidase domain protein
I3S_RS18335	COG0477	Major facilitator Superfamily
I3S_RS18340	COG2086	electron transfer activity
I3S_RS18345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3S_RS18350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3S_RS18355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3S_RS18360	COG0644	oxidoreductase
I3S_RS18365	COG0720	synthase
I3S_RS18375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3S_RS18420	COG1857	crispr-associated protein
I3S_RS18435	COG1518	maintenance of DNA repeat elements
I3S_RS18440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS18445	COG2234	aminopeptidase activity
I3S_RS18500	COG1388	LysM domain
I3S_RS18500	COG4942	peptidase
I3S_RS18505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3S_RS18520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3S_RS18530	COG2610	gluconate transmembrane transporter activity
I3S_RS18535	COG3622	Belongs to the hyi family
I3S_RS18540	COG0235	Class ii aldolase
I3S_RS18545	COG3395	kinase activity
I3S_RS18550	COG2084	Dehydrogenase
I3S_RS18555	COG1349	DNA-binding transcription factor activity
I3S_RS18560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3S_RS18575	COG3604	Transcriptional regulator
I3S_RS18580	COG0309	Hydrogenase expression formation protein (HypE)
I3S_RS18585	COG0409	Hydrogenase expression formation protein
I3S_RS18590	COG0298	carbon dioxide binding
I3S_RS18595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3S_RS18600	COG0375	protein maturation
I3S_RS18610	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS18615	COG0651	ATP synthesis coupled electron transport
I3S_RS18620	COG0650	Formate hydrogenlyase subunit 4
I3S_RS18625	COG3261	NADH dehydrogenase
I3S_RS18625	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I3S_RS18630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3S_RS18635	COG3260	NADH ubiquinone oxidoreductase 20
I3S_RS18645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3S_RS18655	COG4680	protein conserved in bacteria
I3S_RS18660	COG5499	transcription regulator containing HTH domain
I3S_RS18665	COG2723	6-phospho-beta-galactosidase activity
I3S_RS18670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS18670	COG1263	PTS System
I3S_RS18675	COG1609	Transcriptional regulator
I3S_RS18680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS18685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3S_RS18710	COG1349	DNA-binding transcription factor activity
I3S_RS18715	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS18730	COG3732	PTS system glucitol sorbitol-specific
I3S_RS18735	COG3730	PTS system glucitol sorbitol-specific
I3S_RS18740	COG2951	lytic endotransglycosylase activity
I3S_RS18745	COG1546	Belongs to the CinA family
I3S_RS18765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I3S_RS18795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3S_RS18800	COG1238	metal cluster binding
I3S_RS18815	COG2814	Major facilitator Superfamily
I3S_RS18820	COG1566	PFAM secretion protein HlyD family protein
I3S_RS18825	COG1846	Transcriptional regulator
I3S_RS18835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3S_RS18840	COG2814	Major facilitator Superfamily
I3S_RS18850	COG2113	Glycine betaine
I3S_RS18855	COG4176	ABC-type proline glycine betaine transport system permease component
I3S_RS18860	COG4175	Glycine betaine
I3S_RS18865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3S_RS18870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3S_RS18880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3S_RS18885	COG4575	ribosome binding
I3S_RS18900	COG2916	Histone family protein nucleoid-structuring protein H-NS
I3S_RS18905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3S_RS18910	COG0640	Transcriptional regulator
I3S_RS18915	COG0401	homolog of Blt101
I3S_RS18920	COG1652	LysM domain
I3S_RS18925	COG1802	Transcriptional regulator
I3S_RS18930	COG1113	amino acid transport
I3S_RS18935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3S_RS18940	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS18945	COG0579	oxidoreductase
I3S_RS18955	COG0366	Alpha amylase catalytic
I3S_RS19010	COG4974	Belongs to the 'phage' integrase family
I3S_RS19150	COG3772	lysozyme
I3S_RS19270	COG2032	superoxide dismutase activity
I3S_RS19330	COG2867	negative regulation of translational initiation
I3S_RS19340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3S_RS19345	COG0497	DNA recombination
I3S_RS19365	COG4536	flavin adenine dinucleotide binding
I3S_RS19370	COG4137	Cytochrome C assembly protein
I3S_RS19375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I3S_RS19400	COG2885	chlorophyll binding
I3S_RS19420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3S_RS19425	COG0287	Prephenate dehydrogenase
I3S_RS19425	COG1605	Chorismate mutase
I3S_RS19430	COG0077	Prephenate dehydratase
I3S_RS19430	COG1605	Chorismate mutase
I3S_RS19440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3S_RS19450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3S_RS19455	COG0564	pseudouridine synthase activity
I3S_RS19465	COG0542	response to heat
I3S_RS19495	COG0477	Major facilitator Superfamily
I3S_RS19500	COG5544	Lipoprotein
I3S_RS19505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3S_RS19510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3S_RS19510	COG1042	CoA-binding domain protein
I3S_RS19510	COG0045	succinate-CoA ligase (ADP-forming) activity
I3S_RS19515	COG3148	PFAM DTW domain containing protein
I3S_RS19520	COG3118	belongs to the thioredoxin family
I3S_RS19530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3S_RS19550	COG0583	DNA-binding transcription factor activity
I3S_RS19555	COG0513	Belongs to the DEAD box helicase family
I3S_RS19565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3S_RS19570	COG1595	DNA-templated transcription, initiation
I3S_RS19575	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I3S_RS19580	COG3026	antisigma factor binding
I3S_RS19585	COG3086	response to oxidative stress
I3S_RS19595	COG0681	Belongs to the peptidase S26 family
I3S_RS19620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I3S_RS19645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS19650	COG1737	Transcriptional regulator
I3S_RS19655	COG0560	Phosphoserine phosphatase
I3S_RS19670	COG0047	phosphoribosylformylglycinamidine synthase activity
I3S_RS19670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3S_RS19675	COG2205	protein histidine kinase activity
I3S_RS19680	COG3170	Tfp pilus assembly protein FimV
I3S_RS19685	COG2204	response regulator
I3S_RS19690	COG0347	Belongs to the P(II) protein family
I3S_RS19695	COG1017	nitric oxide dioxygenase activity
I3S_RS19695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3S_RS19705	COG1940	carbohydrate kinase activity
I3S_RS19710	COG0457	Tetratricopeptide repeat
I3S_RS19715	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS19720	COG1129	ABC transporter
I3S_RS19725	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS19730	COG1063	alcohol dehydrogenase
I3S_RS19735	COG2017	converts alpha-aldose to the beta-anomer
I3S_RS19740	COG2259	Doxx family
I3S_RS19765	COG4638	Rieske (2fe-2S)
I3S_RS19770	COG0583	DNA-binding transcription factor activity
I3S_RS19775	COG2814	Major facilitator Superfamily
I3S_RS19780	COG3711	transcriptional antiterminator
I3S_RS19785	COG1073	alpha beta
I3S_RS19790	COG0483	inositol monophosphate 1-phosphatase activity
I3S_RS19810	COG0822	iron-sulfur transferase activity
I3S_RS19830	COG0633	Ferredoxin
I3S_RS19835	COG2975	iron-sulfur cluster assembly
I3S_RS19850	COG2897	thiosulfate sulfurtransferase activity
I3S_RS19855	COG2373	Large extracellular alpha-helical protein
I3S_RS19860	COG4953	penicillin-binding protein 1C
I3S_RS19895	COG2976	Protein conserved in bacteria
I3S_RS19910	COG1645	bacterial-type flagellum-dependent swarming motility
I3S_RS19920	COG0516	GMP reductase activity
I3S_RS19920	COG0517	IMP dehydrogenase activity
I3S_RS19935	COG3133	Outer membrane lipoprotein
I3S_RS19955	COG2200	EAL domain
I3S_RS19960	COG0248	Ppx GppA phosphatase
I3S_RS19965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3S_RS19970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I3S_RS19990	COG2233	PERMEase
I3S_RS20000	COG1393	Belongs to the ArsC family
I3S_RS20005	COG4783	chaperone-mediated protein folding
I3S_RS20010	COG0628	permease
I3S_RS20020	COG2116	formate transmembrane transporter activity
I3S_RS20025	COG3604	Transcriptional regulator
I3S_RS20035	COG3260	NADH ubiquinone oxidoreductase 20
I3S_RS20040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3S_RS20045	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I3S_RS20045	COG3261	NADH dehydrogenase
I3S_RS20050	COG0651	ATP synthesis coupled electron transport
I3S_RS20055	COG4237	Hydrogenase 4 membrane
I3S_RS20065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3S_RS20070	COG0650	Formate hydrogenlyase subunit 4
I3S_RS20080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS20085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I3S_RS20090	COG2716	regulation of RNA biosynthetic process
I3S_RS20100	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I3S_RS20120	COG2321	neutral zinc metallopeptidase
I3S_RS20125	COG1444	tRNA N-acetyltransferase activity
I3S_RS20145	COG1393	Belongs to the ArsC family
I3S_RS20160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3S_RS20165	COG3850	Histidine kinase
I3S_RS20170	COG0493	'glutamate synthase
I3S_RS20170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS20180	COG5342	invasion associated locus B
I3S_RS20185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3S_RS20190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3S_RS20195	COG0280	phosphate acetyltransferase
I3S_RS20195	COG0281	malic enzyme
I3S_RS20205	COG4810	utilization protein
I3S_RS20210	COG4917	ethanolamine utilization protein
I3S_RS20215	COG4766	ethanolamine catabolic process
I3S_RS20220	COG4812	Cobalamin adenosyltransferase
I3S_RS20225	COG0280	phosphate acetyltransferase
I3S_RS20230	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3S_RS20235	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I3S_RS20240	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS20245	COG4820	ethanolamine utilization protein (EutJ)
I3S_RS20250	COG1454	alcohol dehydrogenase
I3S_RS20255	COG3192	ethanolamine utilization protein
I3S_RS20260	COG4819	ethanolamine utilization protein
I3S_RS20265	COG4303	Ethanolamine ammonia lyase large subunit
I3S_RS20275	COG4816	utilization protein
I3S_RS20280	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3S_RS20285	COG2207	Transcriptional regulator
I3S_RS20295	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3S_RS20315	COG2837	iron assimilation
I3S_RS20320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3S_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS20350	COG4150	thiosulfate binding
I3S_RS20355	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I3S_RS20360	COG4208	sulfate ABC transporter
I3S_RS20365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3S_RS20370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3S_RS20385	COG2190	(PTS) system
I3S_RS20390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3S_RS20395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS20400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3S_RS20420	COG3530	Putative quorum-sensing-regulated virulence factor
I3S_RS20425	COG0385	Bile acid
I3S_RS20430	COG0583	DNA-binding transcription factor activity
I3S_RS20460	COG3415	Transposase
I3S_RS20465	COG3415	Transposase
I3S_RS20480	COG2200	EAL domain
I3S_RS20480	COG2199	diguanylate cyclase activity
I3S_RS20485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3S_RS20510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS20515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS20520	COG0006	proline dipeptidase activity
I3S_RS20525	COG1363	Peptidase, m42
I3S_RS20535	COG2207	Transcriptional regulator
I3S_RS20540	COG3279	Response regulator of the LytR AlgR family
I3S_RS20545	COG3275	phosphorelay sensor kinase activity
I3S_RS20550	COG0436	Aminotransferase
I3S_RS20560	COG1560	Kdo2-lipid A biosynthetic process
I3S_RS20590	COG0028	Belongs to the TPP enzyme family
I3S_RS20595	COG0679	Auxin Efflux Carrier
I3S_RS20600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3S_RS20605	COG2205	protein histidine kinase activity
I3S_RS20605	COG2198	Histidine kinase
I3S_RS20605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS20605	COG0784	Response regulator, receiver
I3S_RS20610	COG2197	response regulator
I3S_RS20615	COG1566	PFAM secretion protein HlyD family protein
I3S_RS20620	COG0477	Major facilitator Superfamily
I3S_RS20630	COG2610	gluconate transmembrane transporter activity
I3S_RS20635	COG0583	DNA-binding transcription factor activity
I3S_RS20950	COG3772	lysozyme
I3S_RS21105	COG2116	formate transmembrane transporter activity
I3S_RS21115	COG2853	Lipoprotein
I3S_RS21130	COG2067	long-chain fatty acid transport protein
I3S_RS21140	COG3691	Protein conserved in bacteria
I3S_RS21155	COG2062	phosphohistidine phosphatase, SixA
I3S_RS21160	COG3539	Fimbrial protein
I3S_RS21170	COG3121	Chaperone
I3S_RS21175	COG3539	Fimbrial protein
I3S_RS21180	COG3539	Fimbrial protein
I3S_RS21185	COG3539	Fimbrial protein
I3S_RS21200	COG2890	protein-(glutamine-N5) methyltransferase activity
I3S_RS21215	COG0730	response to heat
I3S_RS21220	COG3101	peptidyl-lysine hydroxylation
I3S_RS21235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3S_RS21245	COG2814	Major facilitator Superfamily
I3S_RS21260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3S_RS21270	COG0586	Pfam SNARE associated Golgi protein
I3S_RS21280	COG0285	dihydrofolate synthase activity
I3S_RS21285	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I3S_RS21290	COG1286	toxin biosynthetic process
I3S_RS21295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I3S_RS21300	COG0163	prenyltransferase activity
I3S_RS21305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS21310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS21315	COG4215	(ABC) transporter
I3S_RS21320	COG4160	amino acid transport
I3S_RS21325	COG4598	ABC transporter
I3S_RS21330	COG5464	transposase or invertase
I3S_RS21335	COG1090	epimerase
I3S_RS21340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3S_RS21345	COG0625	glutathione transferase activity
I3S_RS21350	COG0625	glutathione transferase activity
I3S_RS21355	COG0622	Phosphoesterase
I3S_RS21360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3S_RS21365	COG1288	antiporter activity
I3S_RS21370	COG0280	phosphate acetyltransferase
I3S_RS21370	COG0857	belongs to the CobB CobQ family
I3S_RS21375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3S_RS21390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3S_RS21395	COG0471	metal ion transport
I3S_RS21395	COG0490	domain, Protein
I3S_RS21405	COG0436	Aminotransferase
I3S_RS21415	COG0583	DNA-binding transcription factor activity
I3S_RS21435	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I3S_RS21440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3S_RS21445	COG1034	ATP synthesis coupled electron transport
I3S_RS21460	COG0839	Belongs to the complex I subunit 6 family
I3S_RS21470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3S_RS21475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3S_RS21505	COG2153	protein acetylation
I3S_RS21510	COG4575	ribosome binding
I3S_RS21515	COG1169	isochorismate synthase
I3S_RS21530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3S_RS21540	COG0318	PFAM AMP-dependent synthetase and ligase
I3S_RS21605	COG1414	Transcriptional regulator
I3S_RS21615	COG2271	Major facilitator Superfamily
I3S_RS21620	COG3836	Belongs to the HpcH HpaI aldolase family
I3S_RS21625	COG5464	transposase or invertase
I3S_RS21630	COG0247	lactate metabolic process
I3S_RS21640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3S_RS21645	COG2271	Major facilitator Superfamily
I3S_RS21650	COG0584	glycerophosphoryl diester phosphodiesterase
I3S_RS21655	COG0583	DNA-binding transcription factor activity
I3S_RS21660	COG3642	lipopolysaccharide core region biosynthetic process
I3S_RS21665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3S_RS21670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3S_RS21675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3S_RS21685	COG3468	outer membrane autotransporter barrel domain protein
I3S_RS21695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3S_RS21700	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I3S_RS21705	COG3234	Protein of unknown function (DUF1175)
I3S_RS21710	COG2373	Large extracellular alpha-helical protein
I3S_RS21715	COG5445	Predicted secreted protein (DUF2300)
I3S_RS21720	COG4676	Protein conserved in bacteria
I3S_RS21725	COG0183	Belongs to the thiolase family
I3S_RS21730	COG2031	fatty acid transporter
I3S_RS21735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I3S_RS21740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I3S_RS21745	COG2204	response regulator
I3S_RS21750	COG3852	Histidine kinase
I3S_RS21755	COG0784	Response regulator, receiver
I3S_RS21755	COG2205	protein histidine kinase activity
I3S_RS21760	COG2197	response regulator
I3S_RS21765	COG2198	Histidine kinase
I3S_RS21765	COG0642	Histidine kinase
I3S_RS21780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3S_RS21785	COG1477	protein flavinylation
I3S_RS21790	COG2169	Transcriptional regulator
I3S_RS21790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3S_RS21795	COG3145	DNA-N1-methyladenine dioxygenase activity
I3S_RS21800	COG4615	Cyclic peptide transporter
I3S_RS21820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS21820	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3S_RS21825	COG3062	negative regulation of establishment of protein localization
I3S_RS21835	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS21840	COG0348	domain, Protein
I3S_RS21845	COG3043	anaerobic respiration
I3S_RS21850	COG3005	denitrification pathway
I3S_RS21860	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3S_RS21865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3S_RS21870	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3S_RS21880	COG1138	Cytochrome C-type biogenesis protein
I3S_RS21885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3S_RS21890	COG3088	subunit of a heme lyase
I3S_RS21890	COG4235	cytochrome complex assembly
I3S_RS21895	COG2197	response regulator
I3S_RS21905	COG3468	outer membrane autotransporter barrel domain protein
I3S_RS21920	COG3083	sulfuric ester hydrolase activity
I3S_RS21940	COG1061	Type III restriction enzyme res subunit
I3S_RS21950	COG1187	pseudouridine synthase activity
I3S_RS21955	COG2814	Major facilitator Superfamily
I3S_RS21970	COG4172	Belongs to the ABC transporter superfamily
I3S_RS21975	COG4239	(ABC) transporter, permease
I3S_RS21980	COG4174	ABC transporter (Permease)
I3S_RS21985	COG4166	transmembrane transport
I3S_RS21990	COG2200	EAL domain
I3S_RS21995	COG0791	NLP P60 protein
I3S_RS22000	COG0671	phosphoesterase, PA-phosphatase related
I3S_RS22005	COG0523	cobalamin synthesis protein
I3S_RS22010	COG0246	Mannitol dehydrogenase
I3S_RS22025	COG2814	Major facilitator Superfamily
I3S_RS22030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS22030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS22035	COG1105	Belongs to the carbohydrate kinase PfkB family
I3S_RS22040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS22040	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I3S_RS22040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3S_RS22045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS22050	COG2313	pseudouridylate synthase activity
I3S_RS22055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3S_RS22060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3S_RS22070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3S_RS22075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS22075	COG1522	sequence-specific DNA binding
I3S_RS22085	COG2855	membrane
I3S_RS22090	COG0583	DNA-binding transcription factor activity
I3S_RS22100	COG0833	amino acid
I3S_RS22110	COG4771	TonB-dependent receptor
I3S_RS22135	COG2311	Membrane
I3S_RS22145	COG1609	Transcriptional regulator
I3S_RS22150	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS22155	COG1129	ABC transporter
I3S_RS22160	COG4211	Belongs to the binding-protein-dependent transport system permease family
I3S_RS22165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3S_RS22165	COG0167	dihydroorotate dehydrogenase activity
I3S_RS22170	COG0493	'glutamate synthase
I3S_RS22180	COG2949	membrane
I3S_RS22190	COG1346	cytolysis
I3S_RS22200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3S_RS22225	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS22230	COG0586	Pfam SNARE associated Golgi protein
I3S_RS22240	COG1686	Belongs to the peptidase S11 family
I3S_RS22245	COG0277	FAD linked oxidase domain protein
I3S_RS22250	COG1472	Belongs to the glycosyl hydrolase 3 family
I3S_RS22255	COG1732	Glycine betaine
I3S_RS22260	COG1174	glycine betaine transport
I3S_RS22265	COG1125	glycine betaine transport
I3S_RS22270	COG1174	glycine betaine transport
I3S_RS22280	COG0789	Transcriptional regulator
I3S_RS22285	COG3275	phosphorelay sensor kinase activity
I3S_RS22290	COG3279	Response regulator of the LytR AlgR family
I3S_RS22295	COG4807	Protein conserved in bacteria
I3S_RS22300	COG4808	Protein conserved in bacteria
I3S_RS22305	COG4715	Zinc finger, swim domain protein
I3S_RS22310	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3S_RS22315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I3S_RS22320	COG0714	Associated with various cellular activities
I3S_RS22335	COG3831	ATPase activity
I3S_RS22345	COG3831	ATPase activity
I3S_RS22355	COG0489	protein tyrosine kinase activity
I3S_RS22370	COG3539	Fimbrial protein
I3S_RS22375	COG3121	Chaperone
I3S_RS22380	COG3188	usher protein
I3S_RS22385	COG3539	Fimbrial protein
I3S_RS22390	COG5455	response to cobalt ion
I3S_RS22395	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I3S_RS22410	COG0351	phosphomethylpyrimidine kinase
I3S_RS22415	COG3757	hydrolase, family 25
I3S_RS22420	COG2188	Transcriptional regulator
I3S_RS22425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS22430	COG1397	ADP-ribosylglycohydrolase
I3S_RS22435	COG2211	Major facilitator Superfamily
I3S_RS22440	COG1830	Aldolase
I3S_RS22455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS22460	COG3414	Phosphotransferase system galactitol-specific IIB component
I3S_RS22465	COG3775	system Galactitol-specific IIC component
I3S_RS22470	COG1063	alcohol dehydrogenase
I3S_RS22495	COG0826	peptidase U32
I3S_RS22505	COG3609	addiction module antidote protein, CC2985 family
I3S_RS22515	COG0745	RESPONSE REGULATOR receiver
I3S_RS22520	COG2205	protein histidine kinase activity
I3S_RS22560	COG4245	von Willebrand factor, type A
I3S_RS22565	COG0631	protein serine/threonine phosphatase activity
I3S_RS22570	COG3779	Protein conserved in bacteria
I3S_RS22575	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I3S_RS22580	COG0443	Heat shock 70 kDa protein
I3S_RS22585	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I3S_RS22590	COG5002	protein histidine kinase activity
I3S_RS22590	COG5001	Diguanylate cyclase
I3S_RS22590	COG3447	MASE1 domain protein
I3S_RS22595	COG0572	uridine kinase
I3S_RS22605	COG2982	Protein involved in outer membrane biogenesis
I3S_RS22610	COG1253	flavin adenine dinucleotide binding
I3S_RS22615	COG1596	polysaccharide export
I3S_RS22620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3S_RS22625	COG3206	protein involved in exopolysaccharide biosynthesis
I3S_RS22625	COG0489	protein tyrosine kinase activity
I3S_RS22630	COG0463	Glycosyl transferase, family 2
I3S_RS22635	COG1045	serine acetyltransferase
I3S_RS22640	COG0438	transferase activity, transferring glycosyl groups
I3S_RS22650	COG1216	Glycosyl transferase, family 2
I3S_RS22655	COG0110	maltose O-acetyltransferase activity
I3S_RS22660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I3S_RS22665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3S_RS22670	COG1051	belongs to the nudix hydrolase family
I3S_RS22675	COG0297	glycogen (starch) synthase activity
I3S_RS22680	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I3S_RS22680	COG0662	Cupin 2, conserved barrel domain protein
I3S_RS22685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3S_RS22690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3S_RS22695	COG2244	polysaccharide biosynthetic process
I3S_RS22700	COG2327	Polysaccharide pyruvyl transferase
I3S_RS22705	COG0438	transferase activity, transferring glycosyl groups
I3S_RS22715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3S_RS22720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I3S_RS22735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3S_RS22760	COG1215	transferase activity, transferring glycosyl groups
I3S_RS22775	COG0367	asparagine synthase
I3S_RS22780	COG0438	transferase activity, transferring glycosyl groups
I3S_RS22785	COG0438	transferase activity, transferring glycosyl groups
I3S_RS22790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3S_RS22795	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3S_RS22800	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3S_RS22820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3S_RS22825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3S_RS22825	COG0131	Imidazoleglycerol-phosphate dehydratase
I3S_RS22835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3S_RS22855	COG2161	toxin-antitoxin pair type II binding
I3S_RS22860	COG4115	mRNA cleavage
I3S_RS22865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3S_RS22870	COG0583	DNA-binding transcription factor activity
I3S_RS22880	COG0531	amino acid
I3S_RS22885	COG2391	methyltransferase activity
I3S_RS22890	COG0425	Belongs to the sulfur carrier protein TusA family
I3S_RS22895	COG2925	Exonuclease
I3S_RS22900	COG1686	Belongs to the peptidase S11 family
I3S_RS22910	COG1289	transmembrane transporter activity
I3S_RS22935	COG4656	Part of a membrane complex involved in electron transport
I3S_RS22940	COG1454	alcohol dehydrogenase
I3S_RS22940	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS22955	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I3S_RS22970	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3S_RS23030	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I3S_RS23045	COG1376	ErfK ybiS ycfS ynhG family protein
I3S_RS23055	COG0583	DNA-binding transcription factor activity
I3S_RS23060	COG0583	DNA-binding transcription factor activity
I3S_RS23100	COG0582	viral genome integration into host DNA
I3S_RS23110	COG0534	Mate efflux family protein
I3S_RS23130	COG0217	transcriptional regulatory protein
I3S_RS23135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3S_RS23140	COG0477	Major facilitator Superfamily
I3S_RS23160	COG1388	LysM domain
I3S_RS23160	COG1470	cell adhesion involved in biofilm formation
I3S_RS23245	COG3038	cytochrome b561
I3S_RS23250	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3S_RS23265	COG2351	hydroxyisourate hydrolase activity
I3S_RS23270	COG0745	RESPONSE REGULATOR receiver
I3S_RS23275	COG2205	protein histidine kinase activity
I3S_RS23290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3S_RS23300	COG1418	mRNA catabolic process
I3S_RS23305	COG0270	DNA (cytosine-5-)-methyltransferase activity
I3S_RS23310	COG3727	T/G mismatch-specific endonuclease activity
I3S_RS23315	COG0697	spore germination
I3S_RS23320	COG2354	Protein conserved in bacteria
I3S_RS23325	COG5475	Uncharacterized small protein (DUF2158)
I3S_RS23360	COG2197	response regulator
I3S_RS23365	COG1684	flagellar biosynthetic protein fliR
I3S_RS23370	COG1987	bacterial-type flagellum assembly
I3S_RS23375	COG1338	Plays a role in the flagellum-specific transport system
I3S_RS23380	COG3190	flagellar
I3S_RS23385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3S_RS23390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3S_RS23395	COG1580	Controls the rotational direction of flagella during chemotaxis
I3S_RS23400	COG3144	bacterial-type flagellum assembly
I3S_RS23405	COG2882	bacterial-type flagellum organization
I3S_RS23410	COG1157	protein secretion by the type III secretion system
I3S_RS23415	COG1317	bacterial-type flagellum organization
I3S_RS23420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3S_RS23425	COG1766	The M ring may be actively involved in energy transduction
I3S_RS23440	COG2135	peptidase activity
I3S_RS23445	COG0425	Belongs to the sulfur carrier protein TusA family
I3S_RS23450	COG2391	methyltransferase activity
I3S_RS23465	COG0366	Alpha amylase catalytic
I3S_RS23475	COG1516	flagellar protein fliS
I3S_RS23480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I3S_RS23495	COG1191	sigma factor activity
I3S_RS23505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3S_RS23515	COG0765	amino acid transport
I3S_RS23520	COG1126	abc transporter atp-binding protein
I3S_RS23525	COG2197	response regulator
I3S_RS23540	COG2197	response regulator
I3S_RS23630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3S_RS23635	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS23635	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS23720	COG4695	Portal protein
I3S_RS23830	COG4974	Belongs to the 'phage' integrase family
I3S_RS23835	COG3012	SEC-C Motif Domain Protein
I3S_RS23835	COG3318	Belongs to the UPF0149 family
I3S_RS23840	COG0814	amino acid
I3S_RS23850	COG1528	Iron-storage protein
I3S_RS23870	COG1528	Iron-storage protein
I3S_RS23880	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS23885	COG1129	ABC transporter
I3S_RS23890	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS23895	COG1877	trehalose-phosphatase activity
I3S_RS23905	COG0589	response to stress
I3S_RS23920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3S_RS23930	COG0643	Histidine kinase
I3S_RS23930	COG2198	Histidine kinase
I3S_RS23935	COG0835	chemotaxis
I3S_RS23940	COG0840	transmembrane signaling receptor activity
I3S_RS23945	COG0840	transmembrane signaling receptor activity
I3S_RS23950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I3S_RS23955	COG2201	protein-glutamate methylesterase activity
I3S_RS23960	COG0745	RESPONSE REGULATOR receiver
I3S_RS23965	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I3S_RS23970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3S_RS23975	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3S_RS23985	COG3755	Protein conserved in bacteria
I3S_RS23990	COG4372	Transposase
I3S_RS23995	COG3436	PFAM IS66 Orf2 family protein
I3S_RS24000	COG4372	Transposase
I3S_RS24005	COG3436	PFAM IS66 Orf2 family protein
I3S_RS24025	COG3102	Protein conserved in bacteria
I3S_RS24035	COG3005	denitrification pathway
I3S_RS24040	COG0243	molybdopterin cofactor binding
I3S_RS24055	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I3S_RS24060	COG1801	Protein of unknown function DUF72
I3S_RS24065	COG1335	isochorismatase
I3S_RS24075	COG0494	nUDIX hydrolase
I3S_RS24080	COG0217	transcriptional regulatory protein
I3S_RS24110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3S_RS24120	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I3S_RS24125	COG0739	heme binding
I3S_RS24130	COG1560	Kdo2-lipid A biosynthetic process
I3S_RS24135	COG0469	pyruvate kinase activity
I3S_RS24140	COG1737	Transcriptional regulator
I3S_RS24145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I3S_RS24150	COG0129	dihydroxy-acid dehydratase activity
I3S_RS24155	COG0800	Aldolase
I3S_RS24165	COG3141	response to X-ray
I3S_RS24175	COG2979	Protein of unknown function (DUF533)
I3S_RS24180	COG1770	oligopeptidase
I3S_RS24185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS24190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3S_RS24200	COG2372	response to copper ion
I3S_RS24205	COG1276	copper resistance
I3S_RS24215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3S_RS24235	COG3008	intermembrane lipid transfer
I3S_RS24240	COG2995	paraquat-inducible protein a
I3S_RS24245	COG1956	GAF domain-containing protein
I3S_RS24255	COG0793	Belongs to the peptidase S41A family
I3S_RS24265	COG2814	Major facilitator Superfamily
I3S_RS24270	COG1414	Transcriptional regulator
I3S_RS24305	COG2226	methyltransferase
I3S_RS24325	COG3716	PTS system mannose fructose sorbose family IID component
I3S_RS24330	COG3715	PTS system
I3S_RS24335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3S_RS24335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS24350	COG1253	flavin adenine dinucleotide binding
I3S_RS24360	COG1760	l-serine dehydratase
I3S_RS24370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3S_RS24385	COG0251	oxidation-reduction process
I3S_RS24390	COG1199	ATP-dependent helicase activity
I3S_RS24395	COG1214	PFAM Peptidase M22, glycoprotease
I3S_RS24400	COG3065	identical protein binding
I3S_RS24405	COG0318	PFAM AMP-dependent synthetase and ligase
I3S_RS24410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3S_RS24415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3S_RS24420	COG4638	Rieske (2fe-2S)
I3S_RS24425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3S_RS24430	COG0473	3-isopropylmalate dehydrogenase activity
I3S_RS24435	COG0583	DNA-binding transcription factor activity
I3S_RS24445	COG3615	Tellurite resistance protein tehB
I3S_RS24455	COG2261	transglycosylase associated protein
I3S_RS24470	COG2199	diguanylate cyclase activity
I3S_RS24470	COG2203	Gaf domain
I3S_RS24475	COG3042	response to heat
I3S_RS24485	COG2807	transmembrane transport
I3S_RS24490	COG2207	Transcriptional regulator
I3S_RS24505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3S_RS24510	COG2199	diguanylate cyclase activity
I3S_RS24515	COG2199	diguanylate cyclase activity
I3S_RS24525	COG2766	serine protein kinase
I3S_RS24530	COG3713	MltA-interacting MipA family protein
I3S_RS24535	COG0656	L-ascorbic acid biosynthetic process
I3S_RS24540	COG0676	glucose-6-phosphate 1-epimerase activity
I3S_RS24545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3S_RS24555	COG3139	Protein of unknown function (DUF1315)
I3S_RS24560	COG1063	alcohol dehydrogenase
I3S_RS24565	COG2271	Major facilitator Superfamily
I3S_RS24570	COG1063	alcohol dehydrogenase
I3S_RS24575	COG0191	fructose-bisphosphate aldolase activity
I3S_RS24580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3S_RS24585	COG0667	Aldo Keto reductase
I3S_RS24590	COG1349	DNA-binding transcription factor activity
I3S_RS24595	COG2814	Major facilitator Superfamily
I3S_RS24600	COG1335	isochorismatase
I3S_RS24605	COG0252	asparaginase activity
I3S_RS24610	COG0616	signal peptide processing
I3S_RS24635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3S_RS24645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3S_RS24655	COG0494	nUDIX hydrolase
I3S_RS24660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3S_RS24665	COG2897	thiosulfate sulfurtransferase activity
I3S_RS24670	COG4136	ATPase activity
I3S_RS24675	COG4135	transport system, permease component
I3S_RS24680	COG4134	Bacterial extracellular solute-binding protein
I3S_RS24685	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3S_RS24690	COG0398	Pfam SNARE associated Golgi protein
I3S_RS24700	COG0398	Pfam SNARE associated Golgi protein
I3S_RS24705	COG0708	Exodeoxyribonuclease III
I3S_RS24740	COG3678	ATP-independent chaperone mediated protein folding
I3S_RS24750	COG0322	excinuclease ABC activity
I3S_RS24760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3S_RS24770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3S_RS24775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3S_RS24780	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3S_RS24785	COG2169	Transcriptional regulator
I3S_RS24785	COG1917	Cupin 2, conserved barrel domain protein
I3S_RS24790	COG1486	melibiose metabolic process
I3S_RS24800	COG0753	catalase activity
I3S_RS24815	COG1823	symporter activity
I3S_RS24820	COG1988	membrane-bound metal-dependent
I3S_RS24825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3S_RS24835	COG3001	Fructosamine kinase
I3S_RS24845	COG1105	Belongs to the carbohydrate kinase PfkB family
I3S_RS24850	COG3137	Salt-induced outer membrane protein
I3S_RS24910	COG0386	Belongs to the glutathione peroxidase family
I3S_RS24920	COG0791	NLP P60 protein
I3S_RS24925	COG2200	EAL domain
I3S_RS24935	COG4256	Hemin uptake protein
I3S_RS24940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3S_RS24955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3S_RS24955	COG0574	Belongs to the PEP-utilizing enzyme family
I3S_RS24960	COG0318	PFAM AMP-dependent synthetase and ligase
I3S_RS24965	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3S_RS24970	COG0644	oxidoreductase
I3S_RS24975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3S_RS24980	COG2086	electron transfer activity
I3S_RS24990	COG2207	Transcriptional regulator
I3S_RS24990	COG1917	Cupin 2, conserved barrel domain protein
I3S_RS24995	COG1960	acyl-CoA dehydrogenase activity
I3S_RS25000	COG4670	ketone body catabolic process
I3S_RS25020	COG0738	Major facilitator superfamily
I3S_RS25035	COG0628	permease
I3S_RS25045	COG0247	lactate metabolic process
I3S_RS25045	COG0277	FAD linked oxidase domain protein
I3S_RS25050	COG2050	protein possibly involved in aromatic compounds catabolism
I3S_RS25060	COG0316	Belongs to the HesB IscA family
I3S_RS25065	COG0719	Fe-S assembly protein
I3S_RS25070	COG0396	ATPase activity
I3S_RS25075	COG0719	Fe-S assembly protein
I3S_RS25090	COG1376	ErfK ybiS ycfS ynhG family protein
I3S_RS25095	COG4238	major outer membrane lipoprotein
I3S_RS25100	COG0469	pyruvate kinase activity
I3S_RS25110	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS25115	COG2414	aldehyde ferredoxin oxidoreductase
I3S_RS25125	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS25130	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I3S_RS25160	COG3468	outer membrane autotransporter barrel domain protein
I3S_RS25170	COG0307	riboflavin synthase, alpha
I3S_RS25175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3S_RS25180	COG2814	Major facilitator Superfamily
I3S_RS25185	COG0583	DNA-binding transcription factor activity
I3S_RS25205	COG2814	Major facilitator Superfamily
I3S_RS25210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3S_RS25215	COG0791	NLP P60 protein
I3S_RS25220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I3S_RS25225	COG1201	RNA secondary structure unwinding
I3S_RS25235	COG0346	lactoylglutathione lyase activity
I3S_RS25240	COG1902	pentaerythritol trinitrate reductase activity
I3S_RS25245	COG1309	transcriptional regulator
I3S_RS25250	COG3313	Fe-S protein
I3S_RS25255	COG4989	oxidoreductase activity
I3S_RS25260	COG2032	superoxide dismutase activity
I3S_RS25270	COG1566	PFAM secretion protein HlyD family protein
I3S_RS25285	COG3133	Outer membrane lipoprotein
I3S_RS25295	COG3895	Periplasmic Protein
I3S_RS25310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I3S_RS25315	COG0625	glutathione transferase activity
I3S_RS25320	COG3104	oligopeptide transport
I3S_RS25330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I3S_RS25340	COG4659	FMN binding
I3S_RS25385	COG0673	inositol 2-dehydrogenase activity
I3S_RS25395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3S_RS25400	COG1263	PTS System
I3S_RS25400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS25405	COG1609	Transcriptional regulator
I3S_RS25410	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS25415	COG1309	transcriptional regulator
I3S_RS25420	COG3250	beta-galactosidase activity
I3S_RS25435	COG5339	Protein conserved in bacteria
I3S_RS25440	COG1482	cell wall glycoprotein biosynthetic process
I3S_RS25445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3S_RS25445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3S_RS25450	COG0114	fumarate hydratase activity
I3S_RS25460	COG2205	protein histidine kinase activity
I3S_RS25465	COG0745	RESPONSE REGULATOR receiver
I3S_RS25470	COG3136	membrane protein required for alginate biosynthesis
I3S_RS25480	COG0531	amino acid
I3S_RS25495	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I3S_RS25500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I3S_RS25505	COG0628	permease
I3S_RS25525	COG3591	Belongs to the peptidase S1B family
I3S_RS25545	COG2814	Major facilitator Superfamily
I3S_RS25550	COG0583	DNA-binding transcription factor activity
I3S_RS25555	COG1940	carbohydrate kinase activity
I3S_RS25560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3S_RS25570	COG3381	protein complex oligomerization
I3S_RS25575	COG3302	dmso reductase anchor subunit
I3S_RS25580	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS25585	COG0243	molybdopterin cofactor binding
I3S_RS25590	COG0243	molybdopterin cofactor binding
I3S_RS25605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3S_RS25625	COG4948	Mandelate Racemase Muconate Lactonizing
I3S_RS25630	COG1063	alcohol dehydrogenase
I3S_RS25640	COG3436	PFAM IS66 Orf2 family protein
I3S_RS25645	COG4372	Transposase
I3S_RS25650	COG3436	PFAM IS66 Orf2 family protein
I3S_RS25655	COG4372	Transposase
I3S_RS25685	COG1403	HNH endonuclease
I3S_RS25690	COG0484	heat shock protein binding
I3S_RS25700	COG1278	Cold shock
I3S_RS25705	COG1278	Cold shock
I3S_RS25720	COG3772	lysozyme
I3S_RS25730	COG1278	Cold shock
I3S_RS25750	COG5562	phage envelope protein
I3S_RS25775	COG0582	viral genome integration into host DNA
I3S_RS25830	COG0740	serine-type endopeptidase activity
I3S_RS25935	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS25940	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3S_RS25955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3S_RS25965	COG0582	viral genome integration into host DNA
I3S_RS25990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3S_RS26055	COG1846	Transcriptional regulator
I3S_RS26090	COG3111	PFAM Bacterial OB fold (BOF) protein
I3S_RS26100	COG1403	HNH endonuclease
I3S_RS26105	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3S_RS26120	COG2207	Transcriptional regulator
I3S_RS26170	COG3772	lysozyme
I3S_RS26205	COG4220	transposase activity
I3S_RS26325	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS26385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3S_RS26400	COG0305	Participates in initiation and elongation during chromosome replication
I3S_RS26405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3S_RS26410	COG1448	Aminotransferase
I3S_RS26420	COG3700	Belongs to the class B bacterial acid phosphatase family
I3S_RS26425	COG0432	Pfam Uncharacterised protein family UPF0047
I3S_RS26430	COG2315	Protein conserved in bacteria
I3S_RS26435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3S_RS26445	COG0629	single-stranded DNA binding
I3S_RS26460	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I3S_RS26465	COG2207	Transcriptional regulator
I3S_RS26470	COG0789	Transcriptional regulator
I3S_RS26490	COG2252	PERMEase
I3S_RS26495	COG0025	NhaP-type Na H and K H
I3S_RS26510	COG3162	membrane
I3S_RS26515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3S_RS26530	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I3S_RS26535	COG0437	4 iron, 4 sulfur cluster binding
I3S_RS26540	COG3301	Polysulphide reductase, NrfD
I3S_RS26545	COG1138	Cytochrome C-type biogenesis protein
I3S_RS26550	COG3088	subunit of a heme lyase
I3S_RS26555	COG4235	cytochrome complex assembly
I3S_RS26565	COG1301	dicarboxylic acid transport
I3S_RS26570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3S_RS26585	COG1289	transmembrane transporter activity
I3S_RS26590	COG1566	PFAM secretion protein HlyD family protein
I3S_RS26600	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3S_RS26605	COG1940	carbohydrate kinase activity
I3S_RS26610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3S_RS26615	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS26620	COG1129	ABC transporter
I3S_RS26625	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS26630	COG1737	Transcriptional regulator
I3S_RS26640	COG0698	ribose 5-phosphate isomerase
I3S_RS26650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3S_RS26655	COG0456	acetyltransferase
I3S_RS26660	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I3S_RS26665	COG3454	Phosphonate metabolism
I3S_RS26670	COG4778	phosphonate C-P lyase system protein PhnL
I3S_RS26675	COG4107	phosphonate C-P lyase system protein PhnK
I3S_RS26680	COG3627	carbon phosphorus lyase activity
I3S_RS26685	COG3626	phosphonate metabolism
I3S_RS26690	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I3S_RS26695	COG3624	Phosphonate C-P lyase system protein PhnG
I3S_RS26700	COG2188	Transcriptional regulator
I3S_RS26705	COG3639	organic phosphonate transmembrane transporter activity
I3S_RS26715	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I3S_RS26725	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I3S_RS26730	COG2824	Alkylphosphonate utilization operon protein PhnA
I3S_RS26750	COG0477	Major facilitator Superfamily
I3S_RS26760	COG0642	Histidine kinase
I3S_RS26765	COG0745	RESPONSE REGULATOR receiver
I3S_RS26770	COG2194	sulfuric ester hydrolase activity
I3S_RS26775	COG0531	amino acid
I3S_RS26780	COG2207	Transcriptional regulator
I3S_RS26785	COG1982	Orn Lys Arg decarboxylase major
I3S_RS26790	COG2169	Transcriptional regulator
I3S_RS26795	COG1486	melibiose metabolic process
I3S_RS26800	COG2211	Major facilitator Superfamily
I3S_RS26810	COG3647	Membrane
I3S_RS26815	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3S_RS26815	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3S_RS26820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3S_RS26835	COG4565	transcriptional regulatory protein
I3S_RS26840	COG3290	protein histidine kinase activity
I3S_RS26845	COG3592	Divergent 4Fe-4S mono-cluster
I3S_RS26850	COG2388	GCN5-related N-acetyl-transferase
I3S_RS26870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3S_RS26875	COG3104	oligopeptide transport
I3S_RS26880	COG1982	Orn Lys Arg decarboxylase major
I3S_RS26885	COG0531	amino acid
I3S_RS26890	COG3710	Transcriptional regulator
I3S_RS26895	COG4372	Transposase
I3S_RS26900	COG3436	PFAM IS66 Orf2 family protein
I3S_RS27005	COG3436	PFAM IS66 Orf2 family protein
I3S_RS27025	COG0582	viral genome integration into host DNA
I3S_RS27035	COG1309	transcriptional regulator
I3S_RS27050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3S_RS27055	COG1027	Aspartate ammonia-lyase
I3S_RS27060	COG3030	protein affecting phage T7 exclusion by the F plasmid
I3S_RS27065	COG0531	amino acid
I3S_RS27090	COG1509	lysine 2,3-aminomutase activity
I3S_RS27100	COG5510	response to toxic substance
I3S_RS27105	COG5510	response to toxic substance
I3S_RS27110	COG2076	Multidrug Resistance protein
I3S_RS27115	COG3040	lipid binding
I3S_RS27120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3S_RS27135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3S_RS27140	COG1053	succinate dehydrogenase
I3S_RS27150	COG0531	amino acid
I3S_RS27165	COG1511	domain protein
I3S_RS27165	COG3264	Mechanosensitive ion channel
I3S_RS27205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I3S_RS27210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I3S_RS27210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I3S_RS27215	COG0802	atpase or kinase
I3S_RS27220	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3S_RS27240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3S_RS27245	COG0330	HflC and HflK could
I3S_RS27250	COG0330	HflC and HflK could
I3S_RS27255	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I3S_RS27270	COG0557	exoribonuclease II activity
I3S_RS27275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3S_RS27285	COG3789	protein conserved in bacteria
I3S_RS27290	COG1842	Phage shock protein A
I3S_RS27300	COG3766	membrane
I3S_RS27305	COG5463	Belongs to the UPF0441 family
I3S_RS27310	COG0754	glutathionylspermidine amidase activity
I3S_RS27315	COG1960	acyl-CoA dehydrogenase activity
I3S_RS27325	COG3650	response to hydrogen peroxide
I3S_RS27330	COG1073	alpha beta
I3S_RS27345	COG3037	sugar-specific permease SgaT UlaA
I3S_RS27390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3S_RS27400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3S_RS27410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3S_RS27415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3S_RS27420	COG4670	ketone body catabolic process
I3S_RS27425	COG1024	Enoyl-CoA hydratase
I3S_RS27440	COG1309	transcriptional regulator
I3S_RS27445	COG3061	Opacity-associated protein A
I3S_RS27455	COG0545	Peptidyl-prolyl cis-trans isomerase
I3S_RS27460	COG1113	amino acid transport
I3S_RS27470	COG0697	spore germination
I3S_RS27475	COG0702	epimerase
I3S_RS27480	COG1733	regulation of RNA biosynthetic process
I3S_RS27485	COG0737	Belongs to the 5'-nucleotidase family
I3S_RS27490	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3S_RS27495	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3S_RS27505	COG1253	flavin adenine dinucleotide binding
I3S_RS27520	COG0729	surface antigen
I3S_RS27525	COG2911	Protein conserved in bacteria
I3S_RS27530	COG2105	PFAM AIG2 family protein
I3S_RS27535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3S_RS27540	COG1879	ABC-type sugar transport system periplasmic component
I3S_RS27545	COG1129	ABC transporter
I3S_RS27550	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS27555	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3S_RS27565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3S_RS27575	COG0312	modulator of DNA gyrase
I3S_RS27580	COG3783	Cytochrome b(562)
I3S_RS27585	COG0602	queuosine metabolic process
I3S_RS27590	COG1328	CTP reductase activity
I3S_RS27595	COG0366	Alpha amylase catalytic
I3S_RS27600	COG1263	PTS System
I3S_RS27600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3S_RS27605	COG1609	Transcriptional regulator
I3S_RS27615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3S_RS27620	COG0251	oxidation-reduction process
I3S_RS27645	COG0251	oxidation-reduction process
I3S_RS27650	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS27655	COG1309	transcriptional regulator
I3S_RS27660	COG2731	YhcH YjgK YiaL family protein
I3S_RS27675	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I3S_RS27680	COG0456	acetyltransferase
I3S_RS27690	COG0525	valine-tRNA ligase activity
I3S_RS27695	COG2927	DNA polymerase III (CHI subunit)
I3S_RS27705	COG0795	lipopolysaccharide-transporting ATPase activity
I3S_RS27710	COG0795	lipopolysaccharide-transporting ATPase activity
I3S_RS27715	COG0433	COG0433 Predicted ATPase
I3S_RS27720	COG1609	Transcriptional regulator
I3S_RS27725	COG2610	gluconate transmembrane transporter activity
I3S_RS27730	COG1028	Short-chain dehydrogenase reductase Sdr
I3S_RS27735	COG1063	alcohol dehydrogenase
I3S_RS27740	COG3265	gluconokinase activity
I3S_RS27745	COG1064	alcohol dehydrogenase
I3S_RS27760	COG2815	serine threonine protein kinase
I3S_RS27760	COG0515	serine threonine protein kinase
I3S_RS27815	COG1401	restriction endodeoxyribonuclease activity
I3S_RS27835	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I3S_RS27840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3S_RS27850	COG0582	viral genome integration into host DNA
I3S_RS27855	COG4974	Belongs to the 'phage' integrase family
I3S_RS27860	COG3539	Fimbrial protein
I3S_RS27865	COG3539	Fimbrial protein
I3S_RS27870	COG3121	Chaperone
I3S_RS27875	COG3188	usher protein
I3S_RS27880	COG3539	Fimbrial protein
I3S_RS27885	COG3539	Fimbrial protein
I3S_RS27890	COG3539	Fimbrial protein
I3S_RS27910	COG0246	Mannitol dehydrogenase
I3S_RS27920	COG2186	Transcriptional regulator
I3S_RS27940	COG0583	DNA-binding transcription factor activity
I3S_RS27945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3S_RS27950	COG0700	Nucleoside recognition
I3S_RS27955	COG3366	ferrous iron transmembrane transporter activity
I3S_RS27970	COG0477	Major facilitator Superfamily
I3S_RS27985	COG1924	4 iron, 4 sulfur cluster binding
I3S_RS27990	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I3S_RS27995	COG2733	membrane
I3S_RS28000	COG2814	Major facilitator Superfamily
I3S_RS28010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3S_RS28015	COG5457	Domain of unknown function (DUF1127)
I3S_RS28025	COG0523	cobalamin synthesis protein
I3S_RS28030	COG2879	small protein
I3S_RS28035	COG1966	Carbon starvation protein
I3S_RS28045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3S_RS28050	COG2368	4-hydroxyphenylacetate
I3S_RS28070	COG3971	2-oxopent-4-enoate hydratase activity
I3S_RS28080	COG3384	dioxygenase
I3S_RS28085	COG1012	belongs to the aldehyde dehydrogenase family
I3S_RS28090	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3S_RS28095	COG1846	Transcriptional regulator
I3S_RS28100	COG0840	transmembrane signaling receptor activity
I3S_RS28105	COG2271	Major facilitator Superfamily
I3S_RS28110	COG1802	Transcriptional regulator
I3S_RS28115	COG1063	alcohol dehydrogenase
I3S_RS28130	COG1484	DNA-dependent DNA replication
I3S_RS28145	COG2966	Psort location CytoplasmicMembrane, score
I3S_RS28150	COG2197	response regulator
I3S_RS28155	COG2197	response regulator
I3S_RS28160	COG4114	ferric iron reductase
I3S_RS28190	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I3S_RS28195	COG0456	acetyltransferase
I3S_RS28200	COG1011	Hydrolase
I3S_RS28235	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I3S_RS28270	COG3646	Phage regulatory protein
I3S_RS28290	COG4725	Belongs to the MT-A70-like family
I3S_RS28300	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3S_RS28315	COG1403	HNH endonuclease
I3S_RS28445	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3S_RS28490	COG2823	Periplasmic or secreted lipoprotein
I3S_RS28500	COG4667	esterase of the alpha-beta hydrolase superfamily
I3S_RS28505	COG0084	hydrolase, TatD family'
I3S_RS28510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3S_RS28515	COG1328	CTP reductase activity
I3S_RS28545	COG3726	membrane protein affecting hemolysin expression
I3S_RS28550	COG0560	Phosphoserine phosphatase
I3S_RS28555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3S_RS28560	COG1056	cytidyltransferase-related domain
I3S_RS28560	COG3172	ATPase kinase involved in NAD metabolism
I3S_RS28565	COG0488	(ABC) transporter
I3S_RS28575	COG0741	lytic transglycosylase activity
I3S_RS28595	COG3708	Transcriptional regulator
I3S_RS28595	COG2207	Transcriptional regulator
I3S_RS28600	COG3045	CreA protein
I3S_RS28605	COG0745	RESPONSE REGULATOR receiver
I3S_RS28610	COG2205	protein histidine kinase activity
I3S_RS28615	COG4452	Inner membrane protein CreD
I3S_RS28620	COG0745	RESPONSE REGULATOR receiver
I3S_RS28635	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I3S_RS28700	COG3436	PFAM IS66 Orf2 family protein
I3S_RS28705	COG4372	Transposase
I3S_RS28715	COG1560	Kdo2-lipid A biosynthetic process
I3S_RS28720	COG2194	sulfuric ester hydrolase activity
I3S_RS28725	COG0297	glycogen (starch) synthase activity
I3S_RS28730	COG0726	polysaccharide deacetylase
I3S_RS28755	COG2274	protein secretion by the type I secretion system
I3S_RS28890	COG3436	PFAM IS66 Orf2 family protein
I3S_RS28895	COG4372	Transposase
I3S_RS28920	COG4372	Transposase
I3S_RS28925	COG3436	PFAM IS66 Orf2 family protein
I3S_RS29025	COG3468	outer membrane autotransporter barrel domain protein
I3S_RS29040	COG1585	Membrane protein implicated in regulation of membrane protease activity