locus-tag	class	description
E4U86_RS00015	COG3312	ion transport
E4U86_RS00065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4U86_RS00090	COG3539	Fimbrial protein
E4U86_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4U86_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E4U86_RS00110	COG0581	inorganic phosphate transmembrane transporter activity
E4U86_RS00115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4U86_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
E4U86_RS00145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U86_RS00150	COG2252	PERMEase
E4U86_RS00155	COG0431	NADPH-dependent FMN reductase
E4U86_RS00160	COG2091	lysine biosynthetic process via aminoadipic acid
E4U86_RS00175	COG0814	amino acid
E4U86_RS00230	COG0592	DNA-directed DNA polymerase activity
E4U86_RS00240	COG0187	DNA topoisomerase II activity
E4U86_RS00245	COG3753	Protein conserved in bacteria
E4U86_RS00250	COG0561	phosphatase activity
E4U86_RS00260	COG0644	oxidoreductase
E4U86_RS00265	COG0823	Involved in the tonB-independent uptake of proteins
E4U86_RS00270	COG5645	(Lipo)protein
E4U86_RS00290	COG2188	Transcriptional regulator
E4U86_RS00305	COG2207	Transcriptional regulator
E4U86_RS00310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4U86_RS00315	COG3119	arylsulfatase activity
E4U86_RS00325	COG2149	membrane
E4U86_RS00335	COG0641	radical SAM
E4U86_RS00340	COG2814	Major facilitator Superfamily
E4U86_RS00355	COG0028	Belongs to the TPP enzyme family
E4U86_RS00360	COG0440	acetolactate synthase activity
E4U86_RS00380	COG2197	response regulator
E4U86_RS00385	COG3851	Histidine kinase
E4U86_RS00390	COG2271	Major facilitator Superfamily
E4U86_RS00395	COG2271	Major facilitator Superfamily
E4U86_RS00425	COG2814	Major facilitator Superfamily
E4U86_RS00435	COG1464	Belongs to the NlpA lipoprotein family
E4U86_RS00440	COG0697	spore germination
E4U86_RS00445	COG2814	Major facilitator Superfamily
E4U86_RS00610	COG5492	domain, Protein
E4U86_RS00665	COG4372	Transposase
E4U86_RS00670	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS00715	COG0582	viral genome integration into host DNA
E4U86_RS00725	COG2211	Major facilitator Superfamily
E4U86_RS00730	COG1501	Belongs to the glycosyl hydrolase 31 family
E4U86_RS00735	COG2982	Protein involved in outer membrane biogenesis
E4U86_RS00740	COG2233	PERMEase
E4U86_RS00745	COG0786	glutamate:sodium symporter activity
E4U86_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4U86_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U86_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4U86_RS00775	COG0194	GDP metabolic process
E4U86_RS00785	COG2860	membrane
E4U86_RS00790	COG3645	SOS response
E4U86_RS00795	COG1561	YicC-like family, N-terminal region
E4U86_RS00820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4U86_RS00850	COG1519	Transferase
E4U86_RS00855	COG0859	PFAM glycosyl transferase family 9
E4U86_RS00860	COG0438	transferase activity, transferring glycosyl groups
E4U86_RS00865	COG0515	serine threonine protein kinase
E4U86_RS00875	COG3642	lipopolysaccharide core region biosynthetic process
E4U86_RS00895	COG0859	PFAM glycosyl transferase family 9
E4U86_RS00900	COG0859	PFAM glycosyl transferase family 9
E4U86_RS00915	COG0156	8-amino-7-oxononanoate synthase activity
E4U86_RS00925	COG1216	Glycosyl transferase, family 2
E4U86_RS00930	COG2861	carbohydrate metabolic process
E4U86_RS00935	COG4942	peptidase
E4U86_RS00945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U86_RS00950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U86_RS00965	COG1045	serine acetyltransferase
E4U86_RS00970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4U86_RS00980	COG2186	Transcriptional regulator
E4U86_RS00985	COG1620	l-lactate permease
E4U86_RS00990	COG5295	Hep Hag repeat protein
E4U86_RS01010	COG3722	fumarate hydratase activity
E4U86_RS01020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS01020	COG2213	PTS system mannitol-specific
E4U86_RS01030	COG1566	PFAM secretion protein HlyD family protein
E4U86_RS01040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U86_RS01045	COG3209	COG3209 Rhs family protein
E4U86_RS01050	COG0625	glutathione transferase activity
E4U86_RS01060	COG3276	selenocysteine insertion sequence binding
E4U86_RS01065	COG1454	alcohol dehydrogenase
E4U86_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS01085	COG1566	PFAM secretion protein HlyD family protein
E4U86_RS01090	COG0583	DNA-binding transcription factor activity
E4U86_RS01095	COG3713	MltA-interacting MipA family protein
E4U86_RS01105	COG2211	Major facilitator Superfamily
E4U86_RS01115	COG1414	Transcriptional regulator
E4U86_RS01120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS01125	COG3977	Valine--pyruvate aminotransferase
E4U86_RS01130	COG0366	Alpha amylase catalytic
E4U86_RS01135	COG2992	FlgJ-related protein
E4U86_RS01140	COG2207	Transcriptional regulator
E4U86_RS01140	COG1609	Transcriptional regulator
E4U86_RS01145	COG4214	carbohydrate transport
E4U86_RS01155	COG4213	ABC transporter substrate-binding protein
E4U86_RS01165	COG1070	Carbohydrate kinase
E4U86_RS01170	COG4682	membrane
E4U86_RS01175	COG4682	membrane
E4U86_RS01180	COG3274	enterobacterial common antigen metabolic process
E4U86_RS01205	COG1278	Cold shock
E4U86_RS01210	COG2944	sequence-specific DNA binding
E4U86_RS01225	COG2885	chlorophyll binding
E4U86_RS01230	COG0243	molybdopterin cofactor binding
E4U86_RS01235	COG0456	acetyltransferase
E4U86_RS01240	COG2818	Glycosylase
E4U86_RS01245	COG5571	outer membrane autotransporter
E4U86_RS01250	COG2223	nitrite transmembrane transporter activity
E4U86_RS01255	COG3539	Fimbrial protein
E4U86_RS01260	COG3121	Chaperone
E4U86_RS01270	COG3539	Fimbrial protein
E4U86_RS01275	COG3539	Fimbrial protein
E4U86_RS01280	COG2194	sulfuric ester hydrolase activity
E4U86_RS01290	COG0747	negative chemotaxis
E4U86_RS01295	COG0601	transmembrane transport
E4U86_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U86_RS01305	COG0444	Belongs to the ABC transporter superfamily
E4U86_RS01310	COG4608	Belongs to the ABC transporter superfamily
E4U86_RS01315	COG0814	amino acid
E4U86_RS01325	COG2194	sulfuric ester hydrolase activity
E4U86_RS01355	COG1215	transferase activity, transferring glycosyl groups
E4U86_RS01360	COG1215	transferase activity, transferring glycosyl groups
E4U86_RS01365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4U86_RS01370	COG0457	Tetratricopeptide repeat
E4U86_RS01370	COG3118	belongs to the thioredoxin family
E4U86_RS01375	COG2200	EAL domain
E4U86_RS01375	COG2199	diguanylate cyclase activity
E4U86_RS01385	COG0612	Peptidase, M16
E4U86_RS01395	COG2200	EAL domain
E4U86_RS01400	COG2982	Protein involved in outer membrane biogenesis
E4U86_RS01405	COG0477	Major facilitator Superfamily
E4U86_RS01410	COG1295	ribonuclease BN
E4U86_RS01415	COG0583	DNA-binding transcription factor activity
E4U86_RS01420	COG2197	response regulator
E4U86_RS01430	COG1858	cytochrome C peroxidase
E4U86_RS01435	COG0076	glutamate decarboxylase activity
E4U86_RS01440	COG2207	Transcriptional regulator
E4U86_RS01445	COG2207	Transcriptional regulator
E4U86_RS01450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U86_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS01465	COG2771	luxR family
E4U86_RS01470	COG3247	response to pH
E4U86_RS01485	COG1285	pathogenesis
E4U86_RS01490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4U86_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U86_RS01505	COG3721	Heme iron utilization protein
E4U86_RS01515	COG4558	Periplasmic binding protein
E4U86_RS01525	COG4771	TonB-dependent receptor
E4U86_RS01530	COG3720	iron ion transport
E4U86_RS01535	COG2197	response regulator
E4U86_RS01540	COG3065	identical protein binding
E4U86_RS01550	COG1393	Belongs to the ArsC family
E4U86_RS01555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4U86_RS01560	COG0640	Transcriptional regulator
E4U86_RS01570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U86_RS01575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4U86_RS01580	COG0339	signal peptide processing
E4U86_RS01590	COG3104	oligopeptide transport
E4U86_RS01595	COG0589	response to stress
E4U86_RS01605	COG0306	phosphate transporter
E4U86_RS01610	COG2081	HI0933 family
E4U86_RS01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS01635	COG0842	Transport permease protein
E4U86_RS01635	COG1129	ABC transporter
E4U86_RS01640	COG0842	Transport permease protein
E4U86_RS01655	COG0191	fructose-bisphosphate aldolase activity
E4U86_RS01670	COG3775	system Galactitol-specific IIC component
E4U86_RS01675	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U86_RS01685	COG2188	Transcriptional regulator
E4U86_RS01695	COG1124	(ABC) transporter
E4U86_RS01700	COG0444	Belongs to the ABC transporter superfamily
E4U86_RS01705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U86_RS01710	COG0601	transmembrane transport
E4U86_RS01715	COG0747	negative chemotaxis
E4U86_RS01720	COG2091	lysine biosynthetic process via aminoadipic acid
E4U86_RS01725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U86_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS01740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U86_RS01765	COG1216	Glycosyl transferase, family 2
E4U86_RS01785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4U86_RS01795	COG0204	Acyl-transferase
E4U86_RS01815	COG0628	permease
E4U86_RS01830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4U86_RS01845	COG3714	YhhN family
E4U86_RS01855	COG3776	membrane
E4U86_RS01860	COG0742	ribosomal rna small subunit methyltransferase
E4U86_RS01865	COG0552	protein localization to endoplasmic reticulum
E4U86_RS01870	COG2884	Cell division ATP-binding protein ftsE
E4U86_RS01875	COG2177	Part of the ABC transporter FtsEX involved in
E4U86_RS01880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U86_RS01885	COG0683	leucine binding
E4U86_RS01900	COG0456	acetyltransferase
E4U86_RS01905	COG0683	leucine binding
E4U86_RS01910	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS01915	COG4177	L-phenylalanine transmembrane transporter activity
E4U86_RS01920	COG0411	ABC transporter
E4U86_RS01925	COG0410	ABC transporter
E4U86_RS01935	COG1653	transport
E4U86_RS01940	COG1175	transmembrane transport
E4U86_RS01950	COG3842	ATPase activity
E4U86_RS01955	COG0584	glycerophosphoryl diester phosphodiesterase
E4U86_RS01965	COG0405	Gamma-glutamyltransferase
E4U86_RS01975	COG1247	-acetyltransferase
E4U86_RS01980	COG0673	inositol 2-dehydrogenase activity
E4U86_RS01985	COG1741	Belongs to the pirin family
E4U86_RS01990	COG1609	Transcriptional regulator
E4U86_RS01995	COG3265	gluconokinase activity
E4U86_RS02000	COG2610	gluconate transmembrane transporter activity
E4U86_RS02005	COG0514	ATP-dependent DNA helicase (RecQ)
E4U86_RS02025	COG2095	MarC family integral membrane protein
E4U86_RS02030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4U86_RS02035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4U86_RS02055	COG0058	SHG alpha-glucan phosphorylase activity
E4U86_RS02060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4U86_RS02075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4U86_RS02090	COG1349	DNA-binding transcription factor activity
E4U86_RS02095	COG4650	regulator
E4U86_RS02100	COG1690	Belongs to the RtcB family
E4U86_RS02125	COG0058	SHG alpha-glucan phosphorylase activity
E4U86_RS02130	COG1640	4-alpha-glucanotransferase
E4U86_RS02135	COG2610	gluconate transmembrane transporter activity
E4U86_RS02145	COG1040	competence protein
E4U86_RS02155	COG5464	transposase or invertase
E4U86_RS02165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4U86_RS02170	COG1918	ferrous iron import across plasma membrane
E4U86_RS02175	COG2183	response to ionizing radiation
E4U86_RS02180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U86_RS02185	COG0745	RESPONSE REGULATOR receiver
E4U86_RS02190	COG2205	protein histidine kinase activity
E4U86_RS02200	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4U86_RS02210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4U86_RS02215	COG1011	Hydrolase
E4U86_RS02225	COG0494	nUDIX hydrolase
E4U86_RS02230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4U86_RS02235	COG4972	Pilus assembly protein
E4U86_RS02240	COG3166	PFAM Fimbrial assembly family protein
E4U86_RS02255	COG4796	Type ii and iii secretion system protein
E4U86_RS02270	COG3266	domain, Protein
E4U86_RS02275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4U86_RS02280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4U86_RS02285	COG0546	phosphoglycolate phosphatase activity
E4U86_RS02290	COG0180	Tryptophanyl-tRNA synthetase
E4U86_RS02295	COG2188	Transcriptional regulator
E4U86_RS02305	COG1082	Xylose isomerase domain protein TIM barrel
E4U86_RS02310	COG2222	sugar isomerase
E4U86_RS02315	COG0531	amino acid
E4U86_RS02330	COG2116	formate transmembrane transporter activity
E4U86_RS02335	COG2146	nitrite reductase [NAD(P)H] activity
E4U86_RS02340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4U86_RS02350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4U86_RS02360	COG2184	nucleotidyltransferase activity
E4U86_RS02365	COG0512	Glutamine amidotransferase of anthranilate synthase
E4U86_RS02370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4U86_RS02375	COG1289	transmembrane transporter activity
E4U86_RS02380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U86_RS02385	COG1765	OsmC-like protein
E4U86_RS02390	COG3954	Phosphoribulokinase
E4U86_RS02400	COG0429	hydrolase of the alpha beta-hydrolase fold
E4U86_RS02405	COG0488	(ABC) transporter
E4U86_RS02420	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4U86_RS02425	COG1047	Peptidyl-prolyl cis-trans
E4U86_RS02435	COG0545	Peptidyl-prolyl cis-trans isomerase
E4U86_RS02440	COG2964	Protein conserved in bacteria
E4U86_RS02510	COG0089	rRNA binding
E4U86_RS02600	COG0201	protein transport
E4U86_RS02640	COG0789	Transcriptional regulator
E4U86_RS02645	COG3036	rescue of stalled ribosome
E4U86_RS02655	COG0569	domain protein
E4U86_RS02700	COG0551	DNA topoisomerase type I activity
E4U86_RS02705	COG0009	L-threonylcarbamoyladenylate synthase
E4U86_RS02720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4U86_RS02760	COG1126	abc transporter atp-binding protein
E4U86_RS02765	COG0765	amino acid transport
E4U86_RS02770	COG4597	amino acid ABC transporter
E4U86_RS02775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS02790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS02795	COG1309	transcriptional regulator
E4U86_RS02805	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4U86_RS02815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U86_RS02825	COG4145	pantothenate transmembrane transporter activity
E4U86_RS02830	COG3924	membrane
E4U86_RS02835	COG0439	Biotin carboxylase
E4U86_RS02840	COG0511	ligase activity, forming carbon-carbon bonds
E4U86_RS02845	COG0604	alcohol dehydrogenase
E4U86_RS02850	COG2199	diguanylate cyclase activity
E4U86_RS02850	COG2200	EAL domain
E4U86_RS02855	COG1077	Cell shape determining protein MreB Mrl
E4U86_RS02860	COG1792	Involved in formation and maintenance of cell shape
E4U86_RS02865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4U86_RS02870	COG0424	maF-like protein
E4U86_RS02875	COG1530	ribonuclease E activity
E4U86_RS02880	COG3164	Protein of unknown function
E4U86_RS02885	COG0312	modulator of DNA gyrase
E4U86_RS02890	COG0583	DNA-binding transcription factor activity
E4U86_RS02910	COG2732	(Barnase) inhibitor
E4U86_RS02930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U86_RS02935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U86_RS02940	COG3105	Protein conserved in bacteria
E4U86_RS02945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4U86_RS02960	COG0625	glutathione transferase activity
E4U86_RS02965	COG2969	positive regulation of protein catabolic process
E4U86_RS02970	COG3069	C4-dicarboxylate transmembrane transporter activity
E4U86_RS03000	COG2731	YhcH YjgK YiaL family protein
E4U86_RS03005	COG4804	nuclease activity
E4U86_RS03010	COG0493	'glutamate synthase
E4U86_RS03015	COG0070	glutamate synthase
E4U86_RS03015	COG0069	glutamate synthase activity
E4U86_RS03015	COG0067	glutamate synthase
E4U86_RS03020	COG1242	4 iron, 4 sulfur cluster binding
E4U86_RS03025	COG5002	protein histidine kinase activity
E4U86_RS03025	COG2198	Histidine kinase
E4U86_RS03025	COG0784	Response regulator, receiver
E4U86_RS03030	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4U86_RS03040	COG0515	serine threonine protein kinase
E4U86_RS03045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS03060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4U86_RS03065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4U86_RS03070	COG1137	ATPase activity
E4U86_RS03075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4U86_RS03080	COG3117	lipopolysaccharide transmembrane transporter activity
E4U86_RS03085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4U86_RS03090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4U86_RS03090	COG0517	IMP dehydrogenase activity
E4U86_RS03095	COG0530	calcium, potassium:sodium antiporter activity
E4U86_RS03100	COG1127	ABC transporter
E4U86_RS03105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4U86_RS03110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4U86_RS03115	COG2854	intermembrane phospholipid transfer
E4U86_RS03120	COG3113	response to antibiotic
E4U86_RS03125	COG5007	Belongs to the BolA IbaG family
E4U86_RS03135	COG3423	Transcriptional regulator
E4U86_RS03140	COG0142	geranyltranstransferase activity
E4U86_RS03155	COG0697	spore germination
E4U86_RS03165	COG2027	D-alanyl-D-alanine carboxypeptidase
E4U86_RS03170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U86_RS03175	COG1534	Rna-binding protein
E4U86_RS03185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4U86_RS03190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4U86_RS03200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4U86_RS03210	COG2194	sulfuric ester hydrolase activity
E4U86_RS03230	COG0195	Participates in both transcription termination and antitermination
E4U86_RS03270	COG0513	Belongs to the DEAD box helicase family
E4U86_RS03275	COG0814	amino acid
E4U86_RS03280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4U86_RS03285	COG0826	peptidase U32
E4U86_RS03290	COG0826	peptidase U32
E4U86_RS03295	COG3154	lipid carrier protein
E4U86_RS03300	COG3153	acetyltransferase
E4U86_RS03310	COG3787	Belongs to the UPF0306 family
E4U86_RS03315	COG0693	protein deglycase activity
E4U86_RS03320	COG0702	epimerase
E4U86_RS03325	COG0701	Predicted permease
E4U86_RS03330	COG2823	Periplasmic or secreted lipoprotein
E4U86_RS03350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4U86_RS03370	COG3188	usher protein
E4U86_RS03375	COG3121	Chaperone
E4U86_RS03380	COG3539	Fimbrial protein
E4U86_RS03390	COG3716	PTS system mannose fructose sorbose family IID component
E4U86_RS03400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS03410	COG2222	sugar isomerase
E4U86_RS03415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U86_RS03420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS03425	COG3716	PTS system mannose fructose sorbose family IID component
E4U86_RS03435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS03445	COG1349	DNA-binding transcription factor activity
E4U86_RS03455	COG2002	toxin-antitoxin pair type II binding
E4U86_RS03460	COG2721	sulfolactate sulfo-lyase activity
E4U86_RS03465	COG2271	Major facilitator Superfamily
E4U86_RS03475	COG2084	Dehydrogenase
E4U86_RS03480	COG1929	Belongs to the glycerate kinase type-1 family
E4U86_RS03505	COG0583	DNA-binding transcription factor activity
E4U86_RS03510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U86_RS03530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4U86_RS03535	COG1882	Formate acetyltransferase
E4U86_RS03540	COG0251	oxidation-reduction process
E4U86_RS03545	COG1760	l-serine dehydratase
E4U86_RS03550	COG0814	amino acid
E4U86_RS03565	COG1741	Belongs to the pirin family
E4U86_RS03570	COG0583	DNA-binding transcription factor activity
E4U86_RS03575	COG3152	Membrane
E4U86_RS03580	COG3152	Membrane
E4U86_RS03585	COG0435	Glutathione S-transferase
E4U86_RS03590	COG2259	Doxx family
E4U86_RS03600	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E4U86_RS03605	COG4575	ribosome binding
E4U86_RS03610	COG1422	Protein of unknown function (DUF1090)
E4U86_RS03620	COG0586	Pfam SNARE associated Golgi protein
E4U86_RS03625	COG2186	Transcriptional regulator
E4U86_RS03630	COG2271	Major facilitator Superfamily
E4U86_RS03640	COG2721	sulfolactate sulfo-lyase activity
E4U86_RS03650	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4U86_RS03655	COG0861	Integral membrane protein TerC family
E4U86_RS03660	COG0673	inositol 2-dehydrogenase activity
E4U86_RS03665	COG2949	membrane
E4U86_RS03670	COG1451	nucleotide metabolic process
E4U86_RS03680	COG4680	protein conserved in bacteria
E4U86_RS03685	COG5499	transcription regulator containing HTH domain
E4U86_RS03690	COG1902	pentaerythritol trinitrate reductase activity
E4U86_RS03690	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4U86_RS03695	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4U86_RS03695	COG3408	Glycogen debranching enzyme
E4U86_RS03705	COG0531	amino acid
E4U86_RS03710	COG2731	YhcH YjgK YiaL family protein
E4U86_RS03715	COG3250	beta-galactosidase activity
E4U86_RS03720	COG1609	Transcriptional regulator
E4U86_RS03725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4U86_RS03735	COG0840	transmembrane signaling receptor activity
E4U86_RS03740	COG1695	Transcriptional regulator
E4U86_RS03745	COG2375	cellular response to nickel ion
E4U86_RS03760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U86_RS03765	COG0358	DNA primase activity
E4U86_RS03770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4U86_RS03780	COG0471	metal ion transport
E4U86_RS03785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS03790	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS03795	COG0583	DNA-binding transcription factor activity
E4U86_RS03805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4U86_RS03820	COG4991	sh3 domain protein
E4U86_RS03825	COG3025	triphosphatase activity
E4U86_RS03850	COG2268	Band 7 protein
E4U86_RS03855	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4U86_RS03885	COG3384	dioxygenase
E4U86_RS03890	COG0754	glutathionylspermidine amidase activity
E4U86_RS03900	COG1538	Outer membrane efflux protein
E4U86_RS03905	COG0494	nUDIX hydrolase
E4U86_RS03910	COG3151	Protein conserved in bacteria
E4U86_RS03915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4U86_RS03920	COG3150	esterase
E4U86_RS03925	COG0187	DNA topoisomerase II activity
E4U86_RS03930	COG4774	siderophore transport
E4U86_RS03935	COG1120	ATPase activity
E4U86_RS03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U86_RS03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U86_RS03955	COG1737	Transcriptional regulator
E4U86_RS03960	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4U86_RS03965	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4U86_RS03970	COG0642	Histidine kinase
E4U86_RS03975	COG0745	RESPONSE REGULATOR receiver
E4U86_RS03980	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U86_RS03985	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4U86_RS03990	COG4166	transmembrane transport
E4U86_RS03995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4U86_RS04000	COG0204	Acyl-transferase
E4U86_RS04005	COG2132	Multicopper oxidase
E4U86_RS04010	COG1032	radical SAM domain protein
E4U86_RS04015	COG4238	major outer membrane lipoprotein
E4U86_RS04025	COG0656	L-ascorbic acid biosynthetic process
E4U86_RS04030	COG1979	alcohol dehydrogenase
E4U86_RS04035	COG2207	Transcriptional regulator
E4U86_RS04040	COG0586	Pfam SNARE associated Golgi protein
E4U86_RS04045	COG0626	cystathionine gamma-synthase activity
E4U86_RS04050	COG0811	peptide transport
E4U86_RS04055	COG0848	biopolymer transport protein
E4U86_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS04070	COG0667	Aldo Keto reductase
E4U86_RS04085	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4U86_RS04090	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS04095	COG5557	Pfam Polysulphide reductase, NrfD
E4U86_RS04100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4U86_RS04105	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U86_RS04110	COG1773	rubredoxin
E4U86_RS04115	COG0375	protein maturation
E4U86_RS04120	COG0298	carbon dioxide binding
E4U86_RS04125	COG0625	glutathione transferase activity
E4U86_RS04130	COG0754	glutathionylspermidine amidase activity
E4U86_RS04155	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS04160	COG4372	Transposase
E4U86_RS04165	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS04235	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS04250	COG0582	viral genome integration into host DNA
E4U86_RS04260	COG1811	Na channel or pump
E4U86_RS04265	COG1982	Orn Lys Arg decarboxylase major
E4U86_RS04270	COG2211	Major facilitator Superfamily
E4U86_RS04285	COG1194	a g-specific adenine glycosylase
E4U86_RS04295	COG3171	Protein conserved in bacteria
E4U86_RS04305	COG0252	asparaginase activity
E4U86_RS04315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4U86_RS04320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4U86_RS04330	COG0762	integral membrane protein
E4U86_RS04335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4U86_RS04340	COG2805	Type II/IV secretion system protein
E4U86_RS04355	COG0189	ligase activity
E4U86_RS04360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4U86_RS04365	COG2356	endonuclease I
E4U86_RS04370	COG3091	SprT-like family
E4U86_RS04375	COG2814	Major facilitator Superfamily
E4U86_RS04395	COG1166	arginine decarboxylase activity
E4U86_RS04410	COG0501	Belongs to the peptidase M48B family
E4U86_RS04415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4U86_RS04420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS04425	COG2213	PTS system mannitol-specific
E4U86_RS04430	COG1063	alcohol dehydrogenase
E4U86_RS04435	COG1494	fructose-1,6-bisphosphatase
E4U86_RS04445	COG1072	(Pantothenic acid kinase))
E4U86_RS04450	COG1122	ATPase activity
E4U86_RS04455	COG1122	ATPase activity
E4U86_RS04480	COG0126	phosphoglycerate kinase activity
E4U86_RS04485	COG0191	fructose-bisphosphate aldolase activity
E4U86_RS04490	COG0668	transmembrane transport
E4U86_RS04500	COG2968	Membrane
E4U86_RS04510	COG0427	acetyl-CoA hydrolase
E4U86_RS04515	COG1024	Enoyl-CoA hydratase
E4U86_RS04520	COG1703	isobutyryl-CoA mutase activity
E4U86_RS04525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U86_RS04525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U86_RS04540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4U86_RS04555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4U86_RS04575	COG0006	proline dipeptidase activity
E4U86_RS04580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U86_RS04585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U86_RS04610	COG2723	6-phospho-beta-galactosidase activity
E4U86_RS04620	COG1272	protein, Hemolysin III
E4U86_RS04630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4U86_RS04640	COG0716	FMN binding
E4U86_RS04645	COG4974	Belongs to the 'phage' integrase family
E4U86_RS04650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U86_RS04655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4U86_RS04665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4U86_RS04685	COG2233	PERMEase
E4U86_RS04700	COG2252	PERMEase
E4U86_RS04705	COG0402	S-adenosylhomocysteine deaminase activity
E4U86_RS04710	COG2233	PERMEase
E4U86_RS04715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U86_RS04715	COG2080	2 iron, 2 sulfur cluster binding
E4U86_RS04720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U86_RS04725	COG0402	S-adenosylhomocysteine deaminase activity
E4U86_RS04730	COG0493	'glutamate synthase
E4U86_RS04730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS04735	COG2068	MobA-Related Protein
E4U86_RS04740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4U86_RS04745	COG3608	succinylglutamate desuccinylase aspartoacylase
E4U86_RS04745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4U86_RS04750	COG0549	Belongs to the carbamate kinase family
E4U86_RS04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4U86_RS04765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U86_RS04770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4U86_RS04780	COG2080	2 iron, 2 sulfur cluster binding
E4U86_RS04785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U86_RS04790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U86_RS04795	COG4942	peptidase
E4U86_RS04815	COG2207	Transcriptional regulator
E4U86_RS04920	COG2197	response regulator
E4U86_RS04925	COG0741	lytic transglycosylase activity
E4U86_RS04935	COG3710	Transcriptional regulator
E4U86_RS04935	COG0457	Tetratricopeptide repeat
E4U86_RS04945	COG0457	Tetratricopeptide repeat
E4U86_RS04970	COG3710	Transcriptional regulator
E4U86_RS04975	COG2771	luxR family
E4U86_RS04980	COG0814	amino acid
E4U86_RS04985	COG0183	Belongs to the thiolase family
E4U86_RS04995	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS05000	COG2814	Major facilitator Superfamily
E4U86_RS05005	COG1794	racemase activity, acting on amino acids and derivatives
E4U86_RS05010	COG0583	DNA-binding transcription factor activity
E4U86_RS05020	COG1609	Transcriptional regulator
E4U86_RS05035	COG0667	Aldo Keto reductase
E4U86_RS05045	COG0861	Integral membrane protein TerC family
E4U86_RS05060	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E4U86_RS05075	COG2165	general secretion pathway protein
E4U86_RS05080	COG4795	General secretion pathway protein
E4U86_RS05090	COG4967	type IV pilus modification protein PilV
E4U86_RS05095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4U86_RS05100	COG1025	Belongs to the peptidase M16 family
E4U86_RS05105	COG1074	ATP-dependent DNA helicase activity
E4U86_RS05110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4U86_RS05115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4U86_RS05115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4U86_RS05120	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U86_RS05140	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4U86_RS05145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4U86_RS05150	COG2166	iron-sulfur cluster assembly
E4U86_RS05155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4U86_RS05165	COG0583	DNA-binding transcription factor activity
E4U86_RS05170	COG2363	Small membrane protein
E4U86_RS05180	COG1349	DNA-binding transcription factor activity
E4U86_RS05190	COG1070	Carbohydrate kinase
E4U86_RS05200	COG0738	Major facilitator superfamily
E4U86_RS05205	COG0235	Class ii aldolase
E4U86_RS05210	COG1454	alcohol dehydrogenase
E4U86_RS05220	COG1760	l-serine dehydratase
E4U86_RS05225	COG0814	amino acid
E4U86_RS05230	COG1611	Belongs to the LOG family
E4U86_RS05245	COG3098	single-species biofilm formation
E4U86_RS05250	COG0564	pseudouridine synthase activity
E4U86_RS05255	COG0716	FMN binding
E4U86_RS05260	COG2271	Major facilitator Superfamily
E4U86_RS05270	COG4948	Mandelate Racemase Muconate Lactonizing
E4U86_RS05275	COG4999	Histidine kinase
E4U86_RS05275	COG3437	response regulator, receiver
E4U86_RS05275	COG2205	protein histidine kinase activity
E4U86_RS05275	COG3850	Histidine kinase
E4U86_RS05280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4U86_RS05285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4U86_RS05290	COG2336	PFAM SpoVT AbrB
E4U86_RS05295	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4U86_RS05300	COG3956	TIGRFAM MazG family protein
E4U86_RS05315	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4U86_RS05325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4U86_RS05335	COG0602	queuosine metabolic process
E4U86_RS05340	COG1070	Carbohydrate kinase
E4U86_RS05345	COG2223	nitrite transmembrane transporter activity
E4U86_RS05350	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS05355	COG0277	FAD linked oxidase domain protein
E4U86_RS05365	COG2086	electron transfer activity
E4U86_RS05375	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4U86_RS05380	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U86_RS05385	COG0644	oxidoreductase
E4U86_RS05390	COG0720	synthase
E4U86_RS05395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4U86_RS05415	COG1203	CRISPR-associated helicase, Cas3
E4U86_RS05430	COG1857	crispr-associated protein
E4U86_RS05445	COG1518	maintenance of DNA repeat elements
E4U86_RS05450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS05455	COG2234	aminopeptidase activity
E4U86_RS05510	COG1388	LysM domain
E4U86_RS05510	COG4942	peptidase
E4U86_RS05515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U86_RS05520	COG1846	Transcriptional regulator
E4U86_RS05525	COG0163	prenyltransferase activity
E4U86_RS05530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4U86_RS05540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4U86_RS05560	COG3604	Transcriptional regulator
E4U86_RS05565	COG0309	Hydrogenase expression formation protein (HypE)
E4U86_RS05570	COG0409	Hydrogenase expression formation protein
E4U86_RS05575	COG0298	carbon dioxide binding
E4U86_RS05580	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4U86_RS05585	COG0375	protein maturation
E4U86_RS05595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS05600	COG0651	ATP synthesis coupled electron transport
E4U86_RS05605	COG0650	Formate hydrogenlyase subunit 4
E4U86_RS05610	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4U86_RS05610	COG3261	NADH dehydrogenase
E4U86_RS05615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U86_RS05620	COG3260	NADH ubiquinone oxidoreductase 20
E4U86_RS05630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U86_RS05635	COG2723	6-phospho-beta-galactosidase activity
E4U86_RS05640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS05640	COG1263	PTS System
E4U86_RS05645	COG1609	Transcriptional regulator
E4U86_RS05650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS05655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4U86_RS05675	COG0517	IMP dehydrogenase activity
E4U86_RS05675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4U86_RS05680	COG1349	DNA-binding transcription factor activity
E4U86_RS05685	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS05710	COG2951	lytic endotransglycosylase activity
E4U86_RS05715	COG1546	Belongs to the CinA family
E4U86_RS05730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4U86_RS05735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4U86_RS05765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U86_RS05770	COG1238	metal cluster binding
E4U86_RS05785	COG2814	Major facilitator Superfamily
E4U86_RS05790	COG1566	PFAM secretion protein HlyD family protein
E4U86_RS05795	COG1846	Transcriptional regulator
E4U86_RS05805	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4U86_RS05810	COG2814	Major facilitator Superfamily
E4U86_RS05815	COG2113	Glycine betaine
E4U86_RS05820	COG4176	ABC-type proline glycine betaine transport system permease component
E4U86_RS05825	COG4175	Glycine betaine
E4U86_RS05830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U86_RS05845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U86_RS05850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U86_RS05860	COG4575	ribosome binding
E4U86_RS05875	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4U86_RS05880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U86_RS05885	COG0640	Transcriptional regulator
E4U86_RS05890	COG0401	homolog of Blt101
E4U86_RS05895	COG1652	LysM domain
E4U86_RS05900	COG1802	Transcriptional regulator
E4U86_RS05905	COG1113	amino acid transport
E4U86_RS05910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4U86_RS05915	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS05920	COG0579	oxidoreductase
E4U86_RS05955	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS06000	COG2826	transposase and inactivated derivatives, IS30 family
E4U86_RS06060	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS06125	COG2867	negative regulation of translational initiation
E4U86_RS06135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U86_RS06140	COG0497	DNA recombination
E4U86_RS06155	COG4536	flavin adenine dinucleotide binding
E4U86_RS06160	COG4137	Cytochrome C assembly protein
E4U86_RS06165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4U86_RS06190	COG2885	chlorophyll binding
E4U86_RS06195	COG2199	diguanylate cyclase activity
E4U86_RS06210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U86_RS06215	COG1605	Chorismate mutase
E4U86_RS06215	COG0287	Prephenate dehydrogenase
E4U86_RS06220	COG1605	Chorismate mutase
E4U86_RS06220	COG0077	Prephenate dehydratase
E4U86_RS06230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4U86_RS06235	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U86_RS06240	COG0564	pseudouridine synthase activity
E4U86_RS06250	COG0542	response to heat
E4U86_RS06275	COG0477	Major facilitator Superfamily
E4U86_RS06280	COG5544	Lipoprotein
E4U86_RS06285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U86_RS06290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U86_RS06290	COG1042	CoA-binding domain protein
E4U86_RS06290	COG0045	succinate-CoA ligase (ADP-forming) activity
E4U86_RS06300	COG3118	belongs to the thioredoxin family
E4U86_RS06305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U86_RS06320	COG1280	lysine exporter protein (LysE YggA)
E4U86_RS06325	COG0583	DNA-binding transcription factor activity
E4U86_RS06330	COG0513	Belongs to the DEAD box helicase family
E4U86_RS06335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4U86_RS06340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4U86_RS06350	COG1595	DNA-templated transcription, initiation
E4U86_RS06355	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4U86_RS06360	COG3026	antisigma factor binding
E4U86_RS06365	COG3086	response to oxidative stress
E4U86_RS06375	COG0681	Belongs to the peptidase S26 family
E4U86_RS06395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4U86_RS06410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS06415	COG1737	Transcriptional regulator
E4U86_RS06420	COG0560	Phosphoserine phosphatase
E4U86_RS06425	COG0590	tRNA wobble adenosine to inosine editing
E4U86_RS06430	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4U86_RS06435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4U86_RS06435	COG0047	phosphoribosylformylglycinamidine synthase activity
E4U86_RS06440	COG2205	protein histidine kinase activity
E4U86_RS06445	COG3170	Tfp pilus assembly protein FimV
E4U86_RS06450	COG2204	response regulator
E4U86_RS06455	COG0347	Belongs to the P(II) protein family
E4U86_RS06460	COG1017	nitric oxide dioxygenase activity
E4U86_RS06460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U86_RS06470	COG1940	carbohydrate kinase activity
E4U86_RS06475	COG0457	Tetratricopeptide repeat
E4U86_RS06480	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS06485	COG1129	ABC transporter
E4U86_RS06490	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS06495	COG1063	alcohol dehydrogenase
E4U86_RS06500	COG1063	alcohol dehydrogenase
E4U86_RS06505	COG2017	converts alpha-aldose to the beta-anomer
E4U86_RS06510	COG2259	Doxx family
E4U86_RS06535	COG4638	Rieske (2fe-2S)
E4U86_RS06540	COG0583	DNA-binding transcription factor activity
E4U86_RS06545	COG2814	Major facilitator Superfamily
E4U86_RS06550	COG3711	transcriptional antiterminator
E4U86_RS06555	COG1073	alpha beta
E4U86_RS06560	COG0483	inositol monophosphate 1-phosphatase activity
E4U86_RS06580	COG0822	iron-sulfur transferase activity
E4U86_RS06600	COG0633	Ferredoxin
E4U86_RS06605	COG2975	iron-sulfur cluster assembly
E4U86_RS06620	COG2897	thiosulfate sulfurtransferase activity
E4U86_RS06625	COG2373	Large extracellular alpha-helical protein
E4U86_RS06630	COG4953	penicillin-binding protein 1C
E4U86_RS06635	COG0243	molybdopterin cofactor binding
E4U86_RS06640	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS06645	COG3302	dmso reductase anchor subunit
E4U86_RS06680	COG2976	Protein conserved in bacteria
E4U86_RS06695	COG1645	bacterial-type flagellum-dependent swarming motility
E4U86_RS06705	COG0516	GMP reductase activity
E4U86_RS06705	COG0517	IMP dehydrogenase activity
E4U86_RS06720	COG3133	Outer membrane lipoprotein
E4U86_RS06735	COG2200	EAL domain
E4U86_RS06740	COG0248	Ppx GppA phosphatase
E4U86_RS06745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4U86_RS06750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4U86_RS06765	COG2233	PERMEase
E4U86_RS06775	COG1393	Belongs to the ArsC family
E4U86_RS06780	COG4783	chaperone-mediated protein folding
E4U86_RS06785	COG0628	permease
E4U86_RS06790	COG2116	formate transmembrane transporter activity
E4U86_RS06795	COG3604	Transcriptional regulator
E4U86_RS06805	COG3260	NADH ubiquinone oxidoreductase 20
E4U86_RS06810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U86_RS06815	COG3261	NADH dehydrogenase
E4U86_RS06815	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4U86_RS06820	COG0651	ATP synthesis coupled electron transport
E4U86_RS06825	COG4237	Hydrogenase 4 membrane
E4U86_RS06830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4U86_RS06835	COG0650	Formate hydrogenlyase subunit 4
E4U86_RS06840	COG0651	ATP synthesis coupled electron transport
E4U86_RS06845	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS06850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4U86_RS06855	COG2716	regulation of RNA biosynthetic process
E4U86_RS06865	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4U86_RS06875	COG2321	neutral zinc metallopeptidase
E4U86_RS06885	COG0400	carboxylic ester hydrolase activity
E4U86_RS06900	COG1393	Belongs to the ArsC family
E4U86_RS06910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U86_RS06915	COG3850	Histidine kinase
E4U86_RS06920	COG0493	'glutamate synthase
E4U86_RS06920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS06930	COG5342	invasion associated locus B
E4U86_RS06935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4U86_RS06940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U86_RS06945	COG0281	malic enzyme
E4U86_RS06945	COG0280	phosphate acetyltransferase
E4U86_RS06950	COG4810	utilization protein
E4U86_RS06955	COG4917	ethanolamine utilization protein
E4U86_RS06960	COG4766	ethanolamine catabolic process
E4U86_RS06965	COG4812	Cobalamin adenosyltransferase
E4U86_RS06970	COG0280	phosphate acetyltransferase
E4U86_RS06975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4U86_RS06980	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E4U86_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS06990	COG4820	ethanolamine utilization protein (EutJ)
E4U86_RS06995	COG1454	alcohol dehydrogenase
E4U86_RS07000	COG3192	ethanolamine utilization protein
E4U86_RS07005	COG4819	ethanolamine utilization protein
E4U86_RS07010	COG4303	Ethanolamine ammonia lyase large subunit
E4U86_RS07020	COG4816	utilization protein
E4U86_RS07025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4U86_RS07030	COG2207	Transcriptional regulator
E4U86_RS07040	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U86_RS07060	COG2837	iron assimilation
E4U86_RS07065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U86_RS07070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS07070	COG1263	PTS System
E4U86_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS07090	COG4150	thiosulfate binding
E4U86_RS07095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4U86_RS07100	COG4208	sulfate ABC transporter
E4U86_RS07105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4U86_RS07110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4U86_RS07125	COG2190	(PTS) system
E4U86_RS07130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U86_RS07135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS07140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4U86_RS07160	COG3530	Putative quorum-sensing-regulated virulence factor
E4U86_RS07165	COG0385	Bile acid
E4U86_RS07170	COG0583	DNA-binding transcription factor activity
E4U86_RS07210	COG0675	Transposase, IS605 OrfB family
E4U86_RS07215	COG3415	Transposase
E4U86_RS07220	COG3415	Transposase
E4U86_RS07235	COG2200	EAL domain
E4U86_RS07235	COG2199	diguanylate cyclase activity
E4U86_RS07240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U86_RS07265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS07270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS07275	COG0006	proline dipeptidase activity
E4U86_RS07280	COG1363	Peptidase, m42
E4U86_RS07285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U86_RS07285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS07285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS07290	COG2207	Transcriptional regulator
E4U86_RS07295	COG3279	Response regulator of the LytR AlgR family
E4U86_RS07300	COG3275	phosphorelay sensor kinase activity
E4U86_RS07305	COG0436	Aminotransferase
E4U86_RS07315	COG1560	Kdo2-lipid A biosynthetic process
E4U86_RS07340	COG0028	Belongs to the TPP enzyme family
E4U86_RS07345	COG0679	Auxin Efflux Carrier
E4U86_RS07355	COG0784	Response regulator, receiver
E4U86_RS07355	COG2198	Histidine kinase
E4U86_RS07355	COG2205	protein histidine kinase activity
E4U86_RS07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS07360	COG2197	response regulator
E4U86_RS07365	COG1566	PFAM secretion protein HlyD family protein
E4U86_RS07370	COG0477	Major facilitator Superfamily
E4U86_RS07445	COG0582	viral genome integration into host DNA
E4U86_RS07455	COG2116	formate transmembrane transporter activity
E4U86_RS07460	COG2853	Lipoprotein
E4U86_RS07470	COG2067	long-chain fatty acid transport protein
E4U86_RS07475	COG3691	Protein conserved in bacteria
E4U86_RS07490	COG2062	phosphohistidine phosphatase, SixA
E4U86_RS07495	COG3539	Fimbrial protein
E4U86_RS07500	COG3188	usher protein
E4U86_RS07505	COG3121	Chaperone
E4U86_RS07510	COG3539	Fimbrial protein
E4U86_RS07515	COG3539	Fimbrial protein
E4U86_RS07520	COG3539	Fimbrial protein
E4U86_RS07550	COG0730	response to heat
E4U86_RS07555	COG3101	peptidyl-lysine hydroxylation
E4U86_RS07565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4U86_RS07565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4U86_RS07570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U86_RS07575	COG2814	Major facilitator Superfamily
E4U86_RS07590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4U86_RS07600	COG0586	Pfam SNARE associated Golgi protein
E4U86_RS07610	COG0285	dihydrofolate synthase activity
E4U86_RS07615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4U86_RS07620	COG1286	toxin biosynthetic process
E4U86_RS07625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4U86_RS07630	COG0163	prenyltransferase activity
E4U86_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS07640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS07645	COG4215	(ABC) transporter
E4U86_RS07650	COG4160	amino acid transport
E4U86_RS07655	COG4598	ABC transporter
E4U86_RS07660	COG5464	transposase or invertase
E4U86_RS07665	COG1090	epimerase
E4U86_RS07670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4U86_RS07675	COG0625	glutathione transferase activity
E4U86_RS07680	COG0625	glutathione transferase activity
E4U86_RS07685	COG0622	Phosphoesterase
E4U86_RS07690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4U86_RS07695	COG1288	antiporter activity
E4U86_RS07700	COG0280	phosphate acetyltransferase
E4U86_RS07700	COG0857	belongs to the CobB CobQ family
E4U86_RS07705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4U86_RS07720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U86_RS07725	COG0490	domain, Protein
E4U86_RS07725	COG0471	metal ion transport
E4U86_RS07735	COG0436	Aminotransferase
E4U86_RS07740	COG0583	DNA-binding transcription factor activity
E4U86_RS07760	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4U86_RS07765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4U86_RS07770	COG1034	ATP synthesis coupled electron transport
E4U86_RS07785	COG0839	Belongs to the complex I subunit 6 family
E4U86_RS07795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4U86_RS07800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U86_RS07825	COG5160	protein modification by small protein removal
E4U86_RS07830	COG1234	tRNA 3'-trailer cleavage
E4U86_RS07835	COG2153	protein acetylation
E4U86_RS07840	COG4575	ribosome binding
E4U86_RS07845	COG1169	isochorismate synthase
E4U86_RS07860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4U86_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
E4U86_RS07915	COG0406	alpha-ribazole phosphatase activity
E4U86_RS07935	COG1414	Transcriptional regulator
E4U86_RS07940	COG4948	Mandelate Racemase Muconate Lactonizing
E4U86_RS07950	COG3836	Belongs to the HpcH HpaI aldolase family
E4U86_RS07955	COG5464	transposase or invertase
E4U86_RS07960	COG0247	lactate metabolic process
E4U86_RS07970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4U86_RS07975	COG2271	Major facilitator Superfamily
E4U86_RS07980	COG0584	glycerophosphoryl diester phosphodiesterase
E4U86_RS07990	COG0583	DNA-binding transcription factor activity
E4U86_RS07995	COG2814	Major facilitator Superfamily
E4U86_RS08000	COG3642	lipopolysaccharide core region biosynthetic process
E4U86_RS08005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U86_RS08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U86_RS08015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U86_RS08020	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS08030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4U86_RS08035	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E4U86_RS08040	COG3234	Protein of unknown function (DUF1175)
E4U86_RS08050	COG5445	Predicted secreted protein (DUF2300)
E4U86_RS08055	COG5445	Predicted secreted protein (DUF2300)
E4U86_RS08060	COG4676	Protein conserved in bacteria
E4U86_RS08065	COG0784	Response regulator, receiver
E4U86_RS08065	COG2205	protein histidine kinase activity
E4U86_RS08070	COG2197	response regulator
E4U86_RS08075	COG2198	Histidine kinase
E4U86_RS08075	COG0642	Histidine kinase
E4U86_RS08080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U86_RS08085	COG1477	protein flavinylation
E4U86_RS08090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4U86_RS08090	COG2169	Transcriptional regulator
E4U86_RS08095	COG3145	DNA-N1-methyladenine dioxygenase activity
E4U86_RS08100	COG4615	Cyclic peptide transporter
E4U86_RS08115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS08115	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U86_RS08120	COG3062	negative regulation of establishment of protein localization
E4U86_RS08130	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS08135	COG0348	domain, Protein
E4U86_RS08140	COG3043	anaerobic respiration
E4U86_RS08145	COG3005	denitrification pathway
E4U86_RS08150	COG4133	protoheme IX ABC transporter activity
E4U86_RS08155	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U86_RS08160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U86_RS08165	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U86_RS08175	COG1138	Cytochrome C-type biogenesis protein
E4U86_RS08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4U86_RS08185	COG3088	subunit of a heme lyase
E4U86_RS08185	COG4235	cytochrome complex assembly
E4U86_RS08190	COG2197	response regulator
E4U86_RS08195	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS08205	COG3083	sulfuric ester hydrolase activity
E4U86_RS08225	COG1061	Type III restriction enzyme res subunit
E4U86_RS08230	COG1187	pseudouridine synthase activity
E4U86_RS08235	COG2814	Major facilitator Superfamily
E4U86_RS08245	COG4172	Belongs to the ABC transporter superfamily
E4U86_RS08250	COG4239	(ABC) transporter, permease
E4U86_RS08255	COG4174	ABC transporter (Permease)
E4U86_RS08260	COG4166	transmembrane transport
E4U86_RS08265	COG2200	EAL domain
E4U86_RS08270	COG0791	NLP P60 protein
E4U86_RS08275	COG0671	phosphoesterase, PA-phosphatase related
E4U86_RS08280	COG0523	cobalamin synthesis protein
E4U86_RS08285	COG0246	Mannitol dehydrogenase
E4U86_RS08300	COG2814	Major facilitator Superfamily
E4U86_RS08305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS08305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS08310	COG1105	Belongs to the carbohydrate kinase PfkB family
E4U86_RS08315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS08315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS08315	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4U86_RS08320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS08325	COG2313	pseudouridylate synthase activity
E4U86_RS08330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U86_RS08335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U86_RS08345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U86_RS08350	COG1522	sequence-specific DNA binding
E4U86_RS08350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS08360	COG2855	membrane
E4U86_RS08365	COG0583	DNA-binding transcription factor activity
E4U86_RS08370	COG0833	amino acid
E4U86_RS08375	COG4771	TonB-dependent receptor
E4U86_RS08380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4U86_RS08390	COG2311	Membrane
E4U86_RS08395	COG1609	Transcriptional regulator
E4U86_RS08400	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS08405	COG1129	ABC transporter
E4U86_RS08410	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS08415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4U86_RS08415	COG0167	dihydroorotate dehydrogenase activity
E4U86_RS08420	COG0493	'glutamate synthase
E4U86_RS08430	COG2949	membrane
E4U86_RS08440	COG1346	cytolysis
E4U86_RS08455	COG2271	Major facilitator Superfamily
E4U86_RS08470	COG0625	glutathione transferase activity
E4U86_RS08475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U86_RS08480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U86_RS08490	COG1538	Outer membrane efflux protein
E4U86_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS08500	COG0586	Pfam SNARE associated Golgi protein
E4U86_RS08510	COG1686	Belongs to the peptidase S11 family
E4U86_RS08515	COG0277	FAD linked oxidase domain protein
E4U86_RS08520	COG1472	Belongs to the glycosyl hydrolase 3 family
E4U86_RS08525	COG1732	Glycine betaine
E4U86_RS08530	COG1174	glycine betaine transport
E4U86_RS08535	COG1125	glycine betaine transport
E4U86_RS08540	COG1174	glycine betaine transport
E4U86_RS08550	COG0789	Transcriptional regulator
E4U86_RS08555	COG0582	viral genome integration into host DNA
E4U86_RS08775	COG3772	lysozyme
E4U86_RS08825	COG0740	serine-type endopeptidase activity
E4U86_RS08900	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS08915	COG3275	phosphorelay sensor kinase activity
E4U86_RS08920	COG3279	Response regulator of the LytR AlgR family
E4U86_RS08925	COG4807	Protein conserved in bacteria
E4U86_RS08930	COG4808	Protein conserved in bacteria
E4U86_RS08935	COG4715	Zinc finger, swim domain protein
E4U86_RS08940	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4U86_RS08945	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4U86_RS08950	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4U86_RS08955	COG0714	Associated with various cellular activities
E4U86_RS08965	COG3831	ATPase activity
E4U86_RS08985	COG0489	protein tyrosine kinase activity
E4U86_RS08995	COG3539	Fimbrial protein
E4U86_RS09000	COG3121	Chaperone
E4U86_RS09005	COG3188	usher protein
E4U86_RS09010	COG3539	Fimbrial protein
E4U86_RS09015	COG5455	response to cobalt ion
E4U86_RS09020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4U86_RS09050	COG0351	phosphomethylpyrimidine kinase
E4U86_RS09055	COG3757	hydrolase, family 25
E4U86_RS09060	COG2188	Transcriptional regulator
E4U86_RS09065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS09070	COG1397	ADP-ribosylglycohydrolase
E4U86_RS09075	COG2211	Major facilitator Superfamily
E4U86_RS09080	COG1830	Aldolase
E4U86_RS09095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS09100	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U86_RS09105	COG3775	system Galactitol-specific IIC component
E4U86_RS09110	COG1063	alcohol dehydrogenase
E4U86_RS09135	COG3422	double-strand break repair
E4U86_RS09140	COG0745	RESPONSE REGULATOR receiver
E4U86_RS09145	COG2205	protein histidine kinase activity
E4U86_RS09160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U86_RS09185	COG4245	von Willebrand factor, type A
E4U86_RS09190	COG0631	protein serine/threonine phosphatase activity
E4U86_RS09195	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E4U86_RS09200	COG0443	Heat shock 70 kDa protein
E4U86_RS09205	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4U86_RS09215	COG0572	uridine kinase
E4U86_RS09225	COG2982	Protein involved in outer membrane biogenesis
E4U86_RS09240	COG1253	flavin adenine dinucleotide binding
E4U86_RS09250	COG1596	polysaccharide export
E4U86_RS09255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4U86_RS09260	COG0489	protein tyrosine kinase activity
E4U86_RS09260	COG3206	protein involved in exopolysaccharide biosynthesis
E4U86_RS09265	COG0463	Glycosyl transferase, family 2
E4U86_RS09270	COG1045	serine acetyltransferase
E4U86_RS09275	COG0438	transferase activity, transferring glycosyl groups
E4U86_RS09285	COG1216	Glycosyl transferase, family 2
E4U86_RS09290	COG0110	maltose O-acetyltransferase activity
E4U86_RS09295	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4U86_RS09300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U86_RS09305	COG1051	belongs to the nudix hydrolase family
E4U86_RS09310	COG0297	glycogen (starch) synthase activity
E4U86_RS09315	COG0662	Cupin 2, conserved barrel domain protein
E4U86_RS09315	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4U86_RS09320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4U86_RS09325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4U86_RS09330	COG2244	polysaccharide biosynthetic process
E4U86_RS09335	COG2327	Polysaccharide pyruvyl transferase
E4U86_RS09340	COG0438	transferase activity, transferring glycosyl groups
E4U86_RS09350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U86_RS09355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4U86_RS09380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4U86_RS09390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4U86_RS09395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U86_RS09400	COG1051	belongs to the nudix hydrolase family
E4U86_RS09405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4U86_RS09405	COG0662	Cupin 2, conserved barrel domain protein
E4U86_RS09410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4U86_RS09420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4U86_RS09425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4U86_RS09450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4U86_RS09455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4U86_RS09455	COG0131	Imidazoleglycerol-phosphate dehydratase
E4U86_RS09465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4U86_RS09480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U86_RS09485	COG0583	DNA-binding transcription factor activity
E4U86_RS09495	COG0531	amino acid
E4U86_RS09500	COG2391	methyltransferase activity
E4U86_RS09505	COG0425	Belongs to the sulfur carrier protein TusA family
E4U86_RS09510	COG2925	Exonuclease
E4U86_RS09515	COG0582	viral genome integration into host DNA
E4U86_RS09765	COG3772	lysozyme
E4U86_RS09870	COG1185	polyribonucleotide nucleotidyltransferase activity
E4U86_RS09905	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS09925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U86_RS09935	COG1686	Belongs to the peptidase S11 family
E4U86_RS09945	COG1289	transmembrane transporter activity
E4U86_RS09955	COG4917	ethanolamine utilization protein
E4U86_RS09990	COG2003	Belongs to the UPF0758 family
E4U86_RS10040	COG4372	Transposase
E4U86_RS10045	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS10055	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E4U86_RS10070	COG1376	ErfK ybiS ycfS ynhG family protein
E4U86_RS10080	COG0583	DNA-binding transcription factor activity
E4U86_RS10085	COG0583	DNA-binding transcription factor activity
E4U86_RS10095	COG0534	Mate efflux family protein
E4U86_RS10105	COG0217	transcriptional regulatory protein
E4U86_RS10110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4U86_RS10115	COG0477	Major facilitator Superfamily
E4U86_RS10125	COG1388	LysM domain
E4U86_RS10125	COG2373	Large extracellular alpha-helical protein
E4U86_RS10125	COG4932	domain protein
E4U86_RS10155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS10200	COG1846	Transcriptional regulator
E4U86_RS10245	COG1403	HNH endonuclease
E4U86_RS10250	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS10305	COG3772	lysozyme
E4U86_RS10335	COG4220	transposase activity
E4U86_RS10420	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS10440	COG3038	cytochrome b561
E4U86_RS10445	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4U86_RS10460	COG2351	hydroxyisourate hydrolase activity
E4U86_RS10465	COG0745	RESPONSE REGULATOR receiver
E4U86_RS10470	COG2205	protein histidine kinase activity
E4U86_RS10490	COG1418	mRNA catabolic process
E4U86_RS10495	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4U86_RS10500	COG3727	T/G mismatch-specific endonuclease activity
E4U86_RS10505	COG0697	spore germination
E4U86_RS10510	COG2354	Protein conserved in bacteria
E4U86_RS10515	COG5475	Uncharacterized small protein (DUF2158)
E4U86_RS10520	COG3706	GGDEF domain
E4U86_RS10540	COG2197	response regulator
E4U86_RS10545	COG1684	flagellar biosynthetic protein fliR
E4U86_RS10550	COG1987	bacterial-type flagellum assembly
E4U86_RS10555	COG1338	Plays a role in the flagellum-specific transport system
E4U86_RS10560	COG3190	flagellar
E4U86_RS10565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U86_RS10570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U86_RS10575	COG1580	Controls the rotational direction of flagella during chemotaxis
E4U86_RS10580	COG3144	bacterial-type flagellum assembly
E4U86_RS10585	COG2882	bacterial-type flagellum organization
E4U86_RS10590	COG1157	protein secretion by the type III secretion system
E4U86_RS10595	COG1317	bacterial-type flagellum organization
E4U86_RS10600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U86_RS10605	COG1766	The M ring may be actively involved in energy transduction
E4U86_RS10620	COG0454	-acetyltransferase
E4U86_RS10625	COG2135	peptidase activity
E4U86_RS10630	COG0425	Belongs to the sulfur carrier protein TusA family
E4U86_RS10635	COG2391	methyltransferase activity
E4U86_RS10645	COG0366	Alpha amylase catalytic
E4U86_RS10655	COG1516	flagellar protein fliS
E4U86_RS10660	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4U86_RS10670	COG1191	sigma factor activity
E4U86_RS10700	COG2197	response regulator
E4U86_RS10715	COG2197	response regulator
E4U86_RS10755	COG2826	transposase and inactivated derivatives, IS30 family
E4U86_RS10805	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U86_RS10905	COG4974	Belongs to the 'phage' integrase family
E4U86_RS10910	COG3012	SEC-C Motif Domain Protein
E4U86_RS10910	COG3318	Belongs to the UPF0149 family
E4U86_RS10915	COG0814	amino acid
E4U86_RS10925	COG1528	Iron-storage protein
E4U86_RS10945	COG1528	Iron-storage protein
E4U86_RS10950	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS10955	COG1129	ABC transporter
E4U86_RS10960	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS10965	COG1877	trehalose-phosphatase activity
E4U86_RS10975	COG0589	response to stress
E4U86_RS10990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4U86_RS10995	COG1360	Flagellar Motor Protein
E4U86_RS11000	COG0643	Histidine kinase
E4U86_RS11000	COG2198	Histidine kinase
E4U86_RS11005	COG0835	chemotaxis
E4U86_RS11010	COG0840	transmembrane signaling receptor activity
E4U86_RS11015	COG0840	transmembrane signaling receptor activity
E4U86_RS11020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4U86_RS11025	COG2201	protein-glutamate methylesterase activity
E4U86_RS11030	COG0745	RESPONSE REGULATOR receiver
E4U86_RS11040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4U86_RS11045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4U86_RS11055	COG3755	Protein conserved in bacteria
E4U86_RS11065	COG3102	Protein conserved in bacteria
E4U86_RS11075	COG3005	denitrification pathway
E4U86_RS11080	COG0243	molybdopterin cofactor binding
E4U86_RS11095	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4U86_RS11100	COG1801	Protein of unknown function DUF72
E4U86_RS11105	COG1335	isochorismatase
E4U86_RS11110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4U86_RS11115	COG0494	nUDIX hydrolase
E4U86_RS11120	COG0217	transcriptional regulatory protein
E4U86_RS11150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4U86_RS11160	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4U86_RS11165	COG0739	heme binding
E4U86_RS11170	COG1560	Kdo2-lipid A biosynthetic process
E4U86_RS11175	COG0469	pyruvate kinase activity
E4U86_RS11180	COG1737	Transcriptional regulator
E4U86_RS11185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4U86_RS11190	COG0129	dihydroxy-acid dehydratase activity
E4U86_RS11195	COG0800	Aldolase
E4U86_RS11200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4U86_RS11205	COG3141	response to X-ray
E4U86_RS11215	COG2979	Protein of unknown function (DUF533)
E4U86_RS11220	COG1770	oligopeptidase
E4U86_RS11225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS11230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U86_RS11240	COG2372	response to copper ion
E4U86_RS11245	COG1276	copper resistance
E4U86_RS11255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4U86_RS11275	COG3008	intermembrane lipid transfer
E4U86_RS11280	COG2995	paraquat-inducible protein a
E4U86_RS11285	COG1956	GAF domain-containing protein
E4U86_RS11295	COG0793	Belongs to the peptidase S41A family
E4U86_RS11305	COG2814	Major facilitator Superfamily
E4U86_RS11310	COG1414	Transcriptional regulator
E4U86_RS11340	COG2226	methyltransferase
E4U86_RS11355	COG3716	PTS system mannose fructose sorbose family IID component
E4U86_RS11360	COG3715	PTS system
E4U86_RS11365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS11365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS11370	COG1253	flavin adenine dinucleotide binding
E4U86_RS11375	COG2200	EAL domain
E4U86_RS11380	COG1760	l-serine dehydratase
E4U86_RS11390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4U86_RS11405	COG0251	oxidation-reduction process
E4U86_RS11410	COG1199	ATP-dependent helicase activity
E4U86_RS11415	COG1214	PFAM Peptidase M22, glycoprotease
E4U86_RS11420	COG3065	identical protein binding
E4U86_RS11425	COG0318	PFAM AMP-dependent synthetase and ligase
E4U86_RS11430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4U86_RS11435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U86_RS11440	COG4638	Rieske (2fe-2S)
E4U86_RS11445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4U86_RS11450	COG0473	3-isopropylmalate dehydrogenase activity
E4U86_RS11455	COG0583	DNA-binding transcription factor activity
E4U86_RS11460	COG1280	lysine exporter protein (LysE YggA)
E4U86_RS11465	COG3615	Tellurite resistance protein tehB
E4U86_RS11475	COG2261	transglycosylase associated protein
E4U86_RS11495	COG3042	response to heat
E4U86_RS11500	COG3189	MarR family transcriptional regulator
E4U86_RS11505	COG2807	transmembrane transport
E4U86_RS11510	COG2207	Transcriptional regulator
E4U86_RS11525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4U86_RS11530	COG2199	diguanylate cyclase activity
E4U86_RS11535	COG2199	diguanylate cyclase activity
E4U86_RS11545	COG2766	serine protein kinase
E4U86_RS11550	COG3713	MltA-interacting MipA family protein
E4U86_RS11555	COG0656	L-ascorbic acid biosynthetic process
E4U86_RS11560	COG0676	glucose-6-phosphate 1-epimerase activity
E4U86_RS11565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4U86_RS11575	COG3139	Protein of unknown function (DUF1315)
E4U86_RS11580	COG1063	alcohol dehydrogenase
E4U86_RS11585	COG2271	Major facilitator Superfamily
E4U86_RS11590	COG1063	alcohol dehydrogenase
E4U86_RS11595	COG0191	fructose-bisphosphate aldolase activity
E4U86_RS11600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS11605	COG0667	Aldo Keto reductase
E4U86_RS11610	COG1349	DNA-binding transcription factor activity
E4U86_RS11625	COG1335	isochorismatase
E4U86_RS11630	COG0252	asparaginase activity
E4U86_RS11640	COG0616	signal peptide processing
E4U86_RS11645	COG0778	Nitroreductase
E4U86_RS11650	COG0709	Synthesizes selenophosphate from selenide and ATP
E4U86_RS11655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4U86_RS11665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4U86_RS11675	COG0494	nUDIX hydrolase
E4U86_RS11680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4U86_RS11685	COG2897	thiosulfate sulfurtransferase activity
E4U86_RS11690	COG4136	ATPase activity
E4U86_RS11695	COG4135	transport system, permease component
E4U86_RS11700	COG4134	Bacterial extracellular solute-binding protein
E4U86_RS11705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U86_RS11710	COG0398	Pfam SNARE associated Golgi protein
E4U86_RS11720	COG0398	Pfam SNARE associated Golgi protein
E4U86_RS11725	COG0708	Exodeoxyribonuclease III
E4U86_RS11755	COG3678	ATP-independent chaperone mediated protein folding
E4U86_RS11765	COG0322	excinuclease ABC activity
E4U86_RS11775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U86_RS11780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4U86_RS11785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4U86_RS11790	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4U86_RS11795	COG2169	Transcriptional regulator
E4U86_RS11795	COG1917	Cupin 2, conserved barrel domain protein
E4U86_RS11800	COG1486	melibiose metabolic process
E4U86_RS11810	COG0753	catalase activity
E4U86_RS11830	COG1988	membrane-bound metal-dependent
E4U86_RS11835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U86_RS11845	COG3001	Fructosamine kinase
E4U86_RS11855	COG1105	Belongs to the carbohydrate kinase PfkB family
E4U86_RS11860	COG3137	Salt-induced outer membrane protein
E4U86_RS11905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4U86_RS11905	COG0072	phenylalanine-tRNA ligase activity
E4U86_RS11920	COG0386	Belongs to the glutathione peroxidase family
E4U86_RS11930	COG0791	NLP P60 protein
E4U86_RS11935	COG2200	EAL domain
E4U86_RS11945	COG4256	Hemin uptake protein
E4U86_RS11950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U86_RS11960	COG0574	Belongs to the PEP-utilizing enzyme family
E4U86_RS11960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U86_RS11965	COG0318	PFAM AMP-dependent synthetase and ligase
E4U86_RS11970	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U86_RS11975	COG0644	oxidoreductase
E4U86_RS11980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4U86_RS11985	COG2086	electron transfer activity
E4U86_RS11990	COG1917	Cupin 2, conserved barrel domain protein
E4U86_RS11990	COG2207	Transcriptional regulator
E4U86_RS11995	COG1960	acyl-CoA dehydrogenase activity
E4U86_RS12000	COG4670	ketone body catabolic process
E4U86_RS12015	COG2271	Major facilitator Superfamily
E4U86_RS12020	COG0738	Major facilitator superfamily
E4U86_RS12035	COG0628	permease
E4U86_RS12040	COG0277	FAD linked oxidase domain protein
E4U86_RS12040	COG0247	lactate metabolic process
E4U86_RS12045	COG2050	protein possibly involved in aromatic compounds catabolism
E4U86_RS12055	COG0316	Belongs to the HesB IscA family
E4U86_RS12060	COG0719	Fe-S assembly protein
E4U86_RS12065	COG0396	ATPase activity
E4U86_RS12070	COG0719	Fe-S assembly protein
E4U86_RS12085	COG1376	ErfK ybiS ycfS ynhG family protein
E4U86_RS12090	COG4238	major outer membrane lipoprotein
E4U86_RS12095	COG0469	pyruvate kinase activity
E4U86_RS12105	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS12110	COG2414	aldehyde ferredoxin oxidoreductase
E4U86_RS12120	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS12125	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4U86_RS12135	COG4529	Protein conserved in bacteria
E4U86_RS12155	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS12165	COG0307	riboflavin synthase, alpha
E4U86_RS12170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4U86_RS12175	COG2814	Major facilitator Superfamily
E4U86_RS12180	COG0583	DNA-binding transcription factor activity
E4U86_RS12195	COG2814	Major facilitator Superfamily
E4U86_RS12200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4U86_RS12205	COG0791	NLP P60 protein
E4U86_RS12210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4U86_RS12215	COG1201	RNA secondary structure unwinding
E4U86_RS12225	COG0346	lactoylglutathione lyase activity
E4U86_RS12230	COG1902	pentaerythritol trinitrate reductase activity
E4U86_RS12235	COG1309	transcriptional regulator
E4U86_RS12240	COG3313	Fe-S protein
E4U86_RS12250	COG2032	superoxide dismutase activity
E4U86_RS12255	COG1289	transmembrane transporter activity
E4U86_RS12260	COG1566	PFAM secretion protein HlyD family protein
E4U86_RS12275	COG3133	Outer membrane lipoprotein
E4U86_RS12285	COG3895	Periplasmic Protein
E4U86_RS12300	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4U86_RS12305	COG0625	glutathione transferase activity
E4U86_RS12310	COG3104	oligopeptide transport
E4U86_RS12315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4U86_RS12325	COG4659	FMN binding
E4U86_RS12335	COG4656	Part of a membrane complex involved in electron transport
E4U86_RS12365	COG0673	inositol 2-dehydrogenase activity
E4U86_RS12375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4U86_RS12380	COG1263	PTS System
E4U86_RS12380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS12385	COG1609	Transcriptional regulator
E4U86_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS12395	COG1309	transcriptional regulator
E4U86_RS12415	COG5339	Protein conserved in bacteria
E4U86_RS12420	COG1482	cell wall glycoprotein biosynthetic process
E4U86_RS12425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS12425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS12430	COG0114	fumarate hydratase activity
E4U86_RS12440	COG2205	protein histidine kinase activity
E4U86_RS12445	COG0745	RESPONSE REGULATOR receiver
E4U86_RS12450	COG3136	membrane protein required for alginate biosynthesis
E4U86_RS12460	COG0531	amino acid
E4U86_RS12470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4U86_RS12475	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4U86_RS12480	COG0628	permease
E4U86_RS12495	COG3591	Belongs to the peptidase S1B family
E4U86_RS12510	COG2814	Major facilitator Superfamily
E4U86_RS12515	COG0583	DNA-binding transcription factor activity
E4U86_RS12520	COG1940	carbohydrate kinase activity
E4U86_RS12525	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4U86_RS12535	COG3381	protein complex oligomerization
E4U86_RS12540	COG3302	dmso reductase anchor subunit
E4U86_RS12545	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS12550	COG0243	molybdopterin cofactor binding
E4U86_RS12555	COG0243	molybdopterin cofactor binding
E4U86_RS12570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U86_RS12595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS12650	COG1846	Transcriptional regulator
E4U86_RS12655	COG1484	DNA-dependent DNA replication
E4U86_RS12690	COG1403	HNH endonuclease
E4U86_RS12695	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS12745	COG3772	lysozyme
E4U86_RS12880	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS12925	COG4372	Transposase
E4U86_RS12930	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS12980	COG3685	Protein conserved in bacteria
E4U86_RS12985	COG3685	Protein conserved in bacteria
E4U86_RS12990	COG3729	General stress protein
E4U86_RS13005	COG0135	phosphoribosylanthranilate isomerase activity
E4U86_RS13005	COG0134	indole-3-glycerol-phosphate synthase activity
E4U86_RS13010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4U86_RS13010	COG0512	Glutamine amidotransferase of anthranilate synthase
E4U86_RS13015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4U86_RS13025	COG0613	PHP domain protein
E4U86_RS13030	COG0009	L-threonylcarbamoyladenylate synthase
E4U86_RS13035	COG4907	membrane protein (DUF2207)
E4U86_RS13040	COG1187	pseudouridine synthase activity
E4U86_RS13045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4U86_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS13055	COG0616	signal peptide processing
E4U86_RS13065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4U86_RS13070	COG0583	DNA-binding transcription factor activity
E4U86_RS13090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4U86_RS13100	COG0671	phosphoesterase, PA-phosphatase related
E4U86_RS13105	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E4U86_RS13110	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4U86_RS13120	COG0023	Translation Initiation Factor
E4U86_RS13130	COG1349	DNA-binding transcription factor activity
E4U86_RS13140	COG5001	Diguanylate cyclase
E4U86_RS13150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U86_RS13150	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U86_RS13155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4U86_RS13165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS13180	COG2814	Major facilitator Superfamily
E4U86_RS13185	COG4172	Belongs to the ABC transporter superfamily
E4U86_RS13190	COG4172	Belongs to the ABC transporter superfamily
E4U86_RS13195	COG4171	peptide transport system, permease
E4U86_RS13200	COG4168	peptide transport system, permease
E4U86_RS13205	COG4166	transmembrane transport
E4U86_RS13215	COG0531	amino acid
E4U86_RS13225	COG0174	glutamine synthetase
E4U86_RS13230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4U86_RS13235	COG1917	Cupin 2, conserved barrel domain protein
E4U86_RS13235	COG1396	sequence-specific DNA binding
E4U86_RS13240	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS13245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4U86_RS13250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4U86_RS13255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4U86_RS13260	COG1842	Phage shock protein A
E4U86_RS13270	COG1983	PspC domain protein
E4U86_RS13280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U86_RS13295	COG1175	transmembrane transport
E4U86_RS13300	COG0395	ABC-type sugar transport system, permease component
E4U86_RS13305	COG1063	alcohol dehydrogenase
E4U86_RS13310	COG1082	Xylose isomerase domain protein TIM barrel
E4U86_RS13315	COG0673	inositol 2-dehydrogenase activity
E4U86_RS13320	COG1554	hydrolase, family 65, central catalytic
E4U86_RS13325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U86_RS13330	COG3842	ATPase activity
E4U86_RS13340	COG1609	Transcriptional regulator
E4U86_RS13345	COG3106	COG3106 Predicted ATPase
E4U86_RS13355	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E4U86_RS13360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4U86_RS13365	COG4948	Mandelate Racemase Muconate Lactonizing
E4U86_RS13370	COG2866	Carboxypeptidase
E4U86_RS13375	COG0702	epimerase
E4U86_RS13385	COG1073	alpha beta
E4U86_RS13390	COG0583	DNA-binding transcription factor activity
E4U86_RS13395	COG4166	transmembrane transport
E4U86_RS13400	COG0668	transmembrane transport
E4U86_RS13405	COG3182	Iron-regulated membrane protein
E4U86_RS13410	COG0589	response to stress
E4U86_RS13415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U86_RS13420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4U86_RS13430	COG1473	amidohydrolase
E4U86_RS13435	COG1473	amidohydrolase
E4U86_RS13440	COG0583	DNA-binding transcription factor activity
E4U86_RS13445	COG2840	Smr protein MutS2
E4U86_RS13450	COG3706	GGDEF domain
E4U86_RS13465	COG0513	Belongs to the DEAD box helicase family
E4U86_RS13475	COG0582	viral genome integration into host DNA
E4U86_RS13495	COG3723	Recombinational DNA repair protein, rece pathway
E4U86_RS13500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS13515	COG3646	Phage regulatory protein
E4U86_RS13540	COG3756	Protein conserved in bacteria
E4U86_RS13545	COG1484	DNA-dependent DNA replication
E4U86_RS13550	COG1846	Transcriptional regulator
E4U86_RS13620	COG3772	lysozyme
E4U86_RS13670	COG0740	serine-type endopeptidase activity
E4U86_RS13745	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS13770	COG0589	response to stress
E4U86_RS13780	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4U86_RS13780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U86_RS13780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4U86_RS13780	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4U86_RS13785	COG3042	response to heat
E4U86_RS13790	COG3187	Heat shock protein
E4U86_RS13795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4U86_RS13800	COG2911	Protein conserved in bacteria
E4U86_RS13810	COG3784	Protein of unknown function (DUF1318)
E4U86_RS13825	COG0667	Aldo Keto reductase
E4U86_RS13835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4U86_RS13840	COG4589	Belongs to the CDS family
E4U86_RS13845	COG2267	carboxylic ester hydrolase activity
E4U86_RS13850	COG2453	phosphatase
E4U86_RS13850	COG0671	phosphoesterase, PA-phosphatase related
E4U86_RS13855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4U86_RS13860	COG1643	Atp-dependent helicase
E4U86_RS13885	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4U86_RS13890	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS13895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4U86_RS13900	COG3038	cytochrome b561
E4U86_RS13915	COG0840	transmembrane signaling receptor activity
E4U86_RS13920	COG0583	DNA-binding transcription factor activity
E4U86_RS13925	COG5383	Protein conserved in bacteria
E4U86_RS13935	COG2841	Protein conserved in bacteria
E4U86_RS13945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4U86_RS13950	COG1275	C4-dicarboxylate transporter malic acid transport protein
E4U86_RS13955	COG0500	methyltransferase
E4U86_RS13965	COG3135	benzoate transporter
E4U86_RS13970	COG1396	sequence-specific DNA binding
E4U86_RS13975	COG0826	peptidase U32
E4U86_RS13985	COG1724	mRNA binding
E4U86_RS13990	COG1598	PFAM Uncharacterised protein family UPF0150
E4U86_RS13995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4U86_RS14000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U86_RS14005	COG3842	ATPase activity
E4U86_RS14010	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4U86_RS14015	COG1177	transmembrane transport
E4U86_RS14040	COG3238	Protein conserved in bacteria
E4U86_RS14045	COG1247	-acetyltransferase
E4U86_RS14050	COG2130	NADP-dependent
E4U86_RS14055	COG1802	Transcriptional regulator
E4U86_RS14060	COG4772	TonB-dependent receptor
E4U86_RS14065	COG3391	amine dehydrogenase activity
E4U86_RS14070	COG1113	amino acid transport
E4U86_RS14075	COG0625	glutathione transferase activity
E4U86_RS14085	COG3501	Rhs element vgr protein
E4U86_RS14090	COG3209	COG3209 Rhs family protein
E4U86_RS14120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4U86_RS14130	COG0384	phenazine biosynthesis protein PhzF
E4U86_RS14135	COG2181	nitrate reductase activity
E4U86_RS14140	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4U86_RS14145	COG1140	nitrate reductase beta subunit
E4U86_RS14150	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4U86_RS14155	COG2223	nitrite transmembrane transporter activity
E4U86_RS14160	COG4886	Leucine-rich repeat (LRR) protein
E4U86_RS14165	COG4886	Leucine-rich repeat (LRR) protein
E4U86_RS14180	COG0697	spore germination
E4U86_RS14190	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS14195	COG2864	formate dehydrogenase
E4U86_RS14200	COG3093	addiction module antidote protein HigA
E4U86_RS14205	COG1064	alcohol dehydrogenase
E4U86_RS14225	COG1764	response to oxidative stress
E4U86_RS14230	COG4608	Belongs to the ABC transporter superfamily
E4U86_RS14235	COG0444	Belongs to the ABC transporter superfamily
E4U86_RS14240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U86_RS14245	COG0601	transmembrane transport
E4U86_RS14250	COG0747	negative chemotaxis
E4U86_RS14255	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4U86_RS14265	COG3706	GGDEF domain
E4U86_RS14275	COG0531	amino acid
E4U86_RS14280	COG0076	glutamate decarboxylase activity
E4U86_RS14285	COG0612	Peptidase, M16
E4U86_RS14290	COG4771	TonB-dependent receptor
E4U86_RS14295	COG4178	(ABC) transporter
E4U86_RS14305	COG0641	radical SAM
E4U86_RS14310	COG3119	arylsulfatase activity
E4U86_RS14315	COG2207	Transcriptional regulator
E4U86_RS14325	COG0243	molybdopterin cofactor binding
E4U86_RS14330	COG3539	Fimbrial protein
E4U86_RS14335	COG3539	Fimbrial protein
E4U86_RS14340	COG3539	Fimbrial protein
E4U86_RS14345	COG3188	usher protein
E4U86_RS14355	COG3539	Fimbrial protein
E4U86_RS14370	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS14375	COG4372	Transposase
E4U86_RS14390	COG2911	Protein conserved in bacteria
E4U86_RS14390	COG3210	domain, Protein
E4U86_RS14395	COG1070	Carbohydrate kinase
E4U86_RS14405	COG1129	ABC transporter
E4U86_RS14410	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS14415	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS14425	COG1830	Aldolase
E4U86_RS14440	COG3781	membrane
E4U86_RS14450	COG2199	diguanylate cyclase activity
E4U86_RS14460	COG2066	Belongs to the glutaminase family
E4U86_RS14465	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS14470	COG0583	DNA-binding transcription factor activity
E4U86_RS14485	COG2814	Major facilitator Superfamily
E4U86_RS14490	COG2095	MarC family integral membrane protein
E4U86_RS14495	COG1846	Transcriptional regulator
E4U86_RS14500	COG4977	sequence-specific DNA binding
E4U86_RS14510	COG0697	spore germination
E4U86_RS14515	COG2814	Major facilitator Superfamily
E4U86_RS14535	COG3706	GGDEF domain
E4U86_RS14540	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U86_RS14545	COG1546	Belongs to the CinA family
E4U86_RS14550	COG0339	signal peptide processing
E4U86_RS14555	COG4221	oxidoreductase activity
E4U86_RS14560	COG1802	Transcriptional regulator
E4U86_RS14570	COG0246	Mannitol dehydrogenase
E4U86_RS14575	COG0477	Major facilitator Superfamily
E4U86_RS14605	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS14690	COG1030	water channel activity
E4U86_RS14710	COG4220	transposase activity
E4U86_RS14725	COG5562	phage envelope protein
E4U86_RS14760	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS14780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U86_RS14790	COG2076	Multidrug Resistance protein
E4U86_RS14815	COG0582	viral genome integration into host DNA
E4U86_RS14820	COG0538	isocitrate dehydrogenase activity
E4U86_RS14825	COG1187	pseudouridine synthase activity
E4U86_RS14835	COG0482	sulfurtransferase activity
E4U86_RS14845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4U86_RS14850	COG0745	RESPONSE REGULATOR receiver
E4U86_RS14855	COG2205	protein histidine kinase activity
E4U86_RS14865	COG4220	transposase activity
E4U86_RS14955	COG2850	peptidyl-arginine hydroxylation
E4U86_RS14965	COG3842	ATPase activity
E4U86_RS15150	COG3772	lysozyme
E4U86_RS15205	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS15210	COG1403	HNH endonuclease
E4U86_RS15240	COG1846	Transcriptional regulator
E4U86_RS15265	COG1396	sequence-specific DNA binding
E4U86_RS15305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS15315	COG0582	viral genome integration into host DNA
E4U86_RS15320	COG3047	cAMP biosynthetic process
E4U86_RS15340	COG1607	acyl-coa hydrolase
E4U86_RS15345	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4U86_RS15350	COG2350	Protein conserved in bacteria
E4U86_RS15355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4U86_RS15375	COG4608	Belongs to the ABC transporter superfamily
E4U86_RS15380	COG0444	Belongs to the ABC transporter superfamily
E4U86_RS15385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U86_RS15390	COG0601	transmembrane transport
E4U86_RS15395	COG4166	transmembrane transport
E4U86_RS15400	COG2095	MarC family integral membrane protein
E4U86_RS15405	COG1454	alcohol dehydrogenase
E4U86_RS15405	COG1012	belongs to the aldehyde dehydrogenase family
E4U86_RS15410	COG1435	thymidine kinase activity
E4U86_RS15420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4U86_RS15425	COG0745	RESPONSE REGULATOR receiver
E4U86_RS15430	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4U86_RS15440	COG0788	formyltetrahydrofolate deformylase activity
E4U86_RS15470	COG2181	nitrate reductase activity
E4U86_RS15475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4U86_RS15480	COG1140	nitrate reductase beta subunit
E4U86_RS15485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4U86_RS15490	COG2223	nitrite transmembrane transporter activity
E4U86_RS15495	COG3850	Histidine kinase
E4U86_RS15500	COG2197	response regulator
E4U86_RS15505	COG4932	domain protein
E4U86_RS15510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4U86_RS15515	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4U86_RS15520	COG4572	Cation transport regulator
E4U86_RS15525	COG0387	Pfam Sodium calcium exchanger
E4U86_RS15545	COG2912	Transglutaminase-like superfamily
E4U86_RS15550	COG3094	Invasion gene expression up-regulator, SirB
E4U86_RS15580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4U86_RS15585	COG0659	secondary active sulfate transmembrane transporter activity
E4U86_RS15600	COG0012	GTP binding
E4U86_RS15610	COG2376	Dihydroxyacetone kinase
E4U86_RS15615	COG1461	Dihydroxyacetone kinase
E4U86_RS15620	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4U86_RS15620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS15620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U86_RS15645	COG1120	ATPase activity
E4U86_RS15655	COG0157	Belongs to the NadC ModD family
E4U86_RS15680	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4U86_RS15695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4U86_RS15705	COG2719	SpoVR family
E4U86_RS15720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4U86_RS15725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4U86_RS15730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4U86_RS15745	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4U86_RS15775	COG2894	cell division
E4U86_RS15805	COG4571	Outer membrane protease
E4U86_RS15815	COG4372	Transposase
E4U86_RS15820	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS15835	COG0500	methyltransferase
E4U86_RS15840	COG3729	General stress protein
E4U86_RS15845	COG3685	Protein conserved in bacteria
E4U86_RS15850	COG3685	Protein conserved in bacteria
E4U86_RS15855	COG3546	catalase activity
E4U86_RS15860	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U86_RS15865	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS15900	COG1196	nuclear chromosome segregation
E4U86_RS15950	COG1030	water channel activity
E4U86_RS15970	COG4220	transposase activity
E4U86_RS16000	COG3772	lysozyme
E4U86_RS16040	COG2207	Transcriptional regulator
E4U86_RS16055	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS16060	COG1403	HNH endonuclease
E4U86_RS16070	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U86_RS16105	COG1846	Transcriptional regulator
E4U86_RS16160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS16185	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS16190	COG4372	Transposase
E4U86_RS16215	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS16350	COG3772	lysozyme
E4U86_RS16390	COG0484	heat shock protein binding
E4U86_RS16395	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS16400	COG1403	HNH endonuclease
E4U86_RS16455	COG1846	Transcriptional regulator
E4U86_RS16475	COG4197	protein conserved in bacteria, prophage-related
E4U86_RS16505	COG0582	viral genome integration into host DNA
E4U86_RS16510	COG1177	transmembrane transport
E4U86_RS16515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U86_RS16520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4U86_RS16530	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4U86_RS16535	COG1136	(ABC) transporter
E4U86_RS16540	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4U86_RS16545	COG4763	Acyl-transferase
E4U86_RS16550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4U86_RS16555	COG1376	ErfK ybiS ycfS ynhG family protein
E4U86_RS16555	COG1388	LysM domain
E4U86_RS16565	COG1309	transcriptional regulator
E4U86_RS16570	COG3134	Outer membrane lipoprotein
E4U86_RS16575	COG1252	NADH dehydrogenase
E4U86_RS16590	COG0510	thiamine kinase activity
E4U86_RS16595	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E4U86_RS16600	COG5633	Lipoprotein
E4U86_RS16605	COG0537	adenosine 5'-monophosphoramidase activity
E4U86_RS16610	COG4773	Receptor
E4U86_RS16615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS16615	COG1263	PTS System
E4U86_RS16620	COG0084	hydrolase, TatD family'
E4U86_RS16625	COG0470	DNA polymerase III
E4U86_RS16635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4U86_RS16640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4U86_RS16645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U86_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS16660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4U86_RS16680	COG1399	metal-binding, possibly nucleic acid-binding protein
E4U86_RS16685	COG0424	maF-like protein
E4U86_RS16690	COG0564	pseudouridine synthase activity
E4U86_RS16695	COG1530	ribonuclease E activity
E4U86_RS16700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4U86_RS16705	COG1256	bacterial-type flagellum assembly
E4U86_RS16710	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4U86_RS16710	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4U86_RS16725	COG4786	Flagellar basal body rod
E4U86_RS16730	COG4787	bacterial-type flagellum-dependent cell motility
E4U86_RS16735	COG1749	Flagellar hook protein flgE
E4U86_RS16740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4U86_RS16745	COG1558	bacterial-type flagellum-dependent cell motility
E4U86_RS16750	COG1815	bacterial-type flagellum-dependent cell motility
E4U86_RS16755	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4U86_RS16760	COG2747	anti-sigma28 factor FlgM
E4U86_RS16765	COG3418	PFAM FlgN family protein
E4U86_RS16770	COG0728	peptidoglycan biosynthetic process
E4U86_RS16775	COG0673	inositol 2-dehydrogenase activity
E4U86_RS16785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U86_RS16795	COG2999	glutathione oxidoreductase activity
E4U86_RS16830	COG3038	cytochrome b561
E4U86_RS16835	COG2353	YceI-like domain
E4U86_RS16845	COG1560	Kdo2-lipid A biosynthetic process
E4U86_RS16860	COG5645	(Lipo)protein
E4U86_RS16865	COG2943	transferase activity, transferring hexosyl groups
E4U86_RS16880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U86_RS16885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U86_RS16910	COG2197	response regulator
E4U86_RS16925	COG1462	curli production assembly transport component CsgG
E4U86_RS16935	COG3381	protein complex oligomerization
E4U86_RS16985	COG2003	Belongs to the UPF0758 family
E4U86_RS17015	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS17060	COG1475	DNA binding
E4U86_RS17065	COG3969	phosphoadenosine phosphosulfate
E4U86_RS17070	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E4U86_RS17080	COG2831	hemolysin activation secretion protein
E4U86_RS17165	COG4771	TonB-dependent receptor
E4U86_RS17225	COG1358	cellular component organization or biogenesis
E4U86_RS17260	COG4372	Transposase
E4U86_RS17265	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS17290	COG0254	rRNA binding
E4U86_RS17335	COG0829	nickel cation binding
E4U86_RS17345	COG2194	sulfuric ester hydrolase activity
E4U86_RS17350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4U86_RS17390	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS17395	COG4372	Transposase
E4U86_RS17425	COG4983	Phage plasmid primase, P4 family domain protein
E4U86_RS17450	COG0582	viral genome integration into host DNA
E4U86_RS17500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U86_RS17505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4U86_RS17515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4U86_RS17525	COG0736	holo-[acyl-carrier-protein] synthase activity
E4U86_RS17530	COG2831	hemolysin activation secretion protein
E4U86_RS17535	COG3210	domain, Protein
E4U86_RS17545	COG3539	Fimbrial protein
E4U86_RS17555	COG3188	usher protein
E4U86_RS17565	COG3121	Chaperone
E4U86_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS17575	COG3710	Transcriptional regulator
E4U86_RS17585	COG2200	EAL domain
E4U86_RS17590	COG3706	GGDEF domain
E4U86_RS17595	COG0457	Tetratricopeptide repeat
E4U86_RS17600	COG1649	PFAM Uncharacterised BCR, COG1649
E4U86_RS17600	COG0726	polysaccharide deacetylase
E4U86_RS17605	COG1215	transferase activity, transferring glycosyl groups
E4U86_RS17610	COG3658	cytochrome
E4U86_RS17615	COG1702	phosphate starvation-inducible protein PhoH
E4U86_RS17620	COG2837	iron assimilation
E4U86_RS17625	COG2822	iron ion transport
E4U86_RS17640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4U86_RS17650	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U86_RS17650	COG0506	proline dehydrogenase activity
E4U86_RS17650	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U86_RS17655	COG1309	transcriptional regulator
E4U86_RS17690	COG2233	PERMEase
E4U86_RS17695	COG3729	General stress protein
E4U86_RS17735	COG0243	molybdopterin cofactor binding
E4U86_RS17740	COG3005	denitrification pathway
E4U86_RS17745	COG0745	RESPONSE REGULATOR receiver
E4U86_RS17750	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS17755	COG2205	protein histidine kinase activity
E4U86_RS17755	COG2198	Histidine kinase
E4U86_RS17755	COG0784	Response regulator, receiver
E4U86_RS17760	COG0348	domain, Protein
E4U86_RS17780	COG1278	Cold shock
E4U86_RS17785	COG1278	Cold shock
E4U86_RS17805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U86_RS17810	COG1596	polysaccharide export
E4U86_RS17815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4U86_RS17820	COG3206	protein involved in exopolysaccharide biosynthesis
E4U86_RS17820	COG0489	protein tyrosine kinase activity
E4U86_RS17835	COG1294	oxidase, subunit
E4U86_RS17840	COG1271	oxidase subunit
E4U86_RS17845	COG1773	rubredoxin
E4U86_RS17850	COG1999	signal sequence binding
E4U86_RS17855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U86_RS17860	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E4U86_RS17865	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4U86_RS17870	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4U86_RS17890	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS17905	COG2032	superoxide dismutase activity
E4U86_RS17985	COG4372	Transposase
E4U86_RS17990	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS18015	COG3772	lysozyme
E4U86_RS18065	COG2207	Transcriptional regulator
E4U86_RS18085	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS18090	COG1403	HNH endonuclease
E4U86_RS18120	COG1846	Transcriptional regulator
E4U86_RS18125	COG1484	DNA-dependent DNA replication
E4U86_RS18190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS18205	COG0670	Belongs to the BI1 family
E4U86_RS18210	COG2920	part of a sulfur-relay system
E4U86_RS18215	COG1254	Belongs to the acylphosphatase family
E4U86_RS18230	COG1832	CoA-binding protein
E4U86_RS18245	COG0210	DNA helicase
E4U86_RS18250	COG3304	Inner membrane component domain
E4U86_RS18255	COG1289	transmembrane transporter activity
E4U86_RS18260	COG3070	regulator of competence-specific genes
E4U86_RS18270	COG2885	chlorophyll binding
E4U86_RS18270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4U86_RS18280	COG1067	ATP-dependent peptidase activity
E4U86_RS18290	COG3130	regulation of translation
E4U86_RS18295	COG3009	Protein conserved in bacteria
E4U86_RS18300	COG3008	intermembrane lipid transfer
E4U86_RS18300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4U86_RS18305	COG2995	paraquat-inducible protein a
E4U86_RS18310	COG0488	(ABC) transporter
E4U86_RS18320	COG3217	Mosc domain protein beta barrel domain protein
E4U86_RS18320	COG0633	Ferredoxin
E4U86_RS18340	COG3539	Fimbrial protein
E4U86_RS18345	COG3539	Fimbrial protein
E4U86_RS18350	COG3539	Fimbrial protein
E4U86_RS18360	COG3121	Chaperone
E4U86_RS18365	COG3539	Fimbrial protein
E4U86_RS18370	COG0431	NADPH-dependent FMN reductase
E4U86_RS18375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4U86_RS18385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4U86_RS18390	COG1116	anion transmembrane transporter activity
E4U86_RS18395	COG0308	aminopeptidase N
E4U86_RS18405	COG0017	Asparaginyl-tRNA synthetase
E4U86_RS18410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U86_RS18415	COG1448	Aminotransferase
E4U86_RS18420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4U86_RS18425	COG3108	Peptidase M15
E4U86_RS18430	COG2989	Protein conserved in bacteria
E4U86_RS18440	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4U86_RS18450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4U86_RS18455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4U86_RS18460	COG3173	Aminoglycoside phosphotransferase
E4U86_RS18475	COG3214	Protein conserved in bacteria
E4U86_RS18485	COG1132	(ABC) transporter
E4U86_RS18490	COG2333	competence protein COMEC
E4U86_RS18490	COG0658	competence protein
E4U86_RS18500	COG0539	negative regulation of cytoplasmic translation
E4U86_RS18510	COG0501	Belongs to the peptidase M48B family
E4U86_RS18525	COG2323	membrane
E4U86_RS18530	COG1944	ATP diphosphatase activity
E4U86_RS18535	COG2116	formate transmembrane transporter activity
E4U86_RS18540	COG1882	Formate acetyltransferase
E4U86_RS18545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U86_RS18555	COG0531	amino acid
E4U86_RS18565	COG1335	isochorismatase
E4U86_RS18570	COG3302	dmso reductase anchor subunit
E4U86_RS18575	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS18580	COG0243	molybdopterin cofactor binding
E4U86_RS18590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4U86_RS18600	COG1674	ftsk spoiiie
E4U86_RS18600	COG1178	ABC-type Fe3 transport system permease component
E4U86_RS18605	COG1522	sequence-specific DNA binding
E4U86_RS18610	COG0492	ferredoxin-NADP+ reductase activity
E4U86_RS18615	COG4988	ABC transporter
E4U86_RS18620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4U86_RS18670	COG2003	Belongs to the UPF0758 family
E4U86_RS18700	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS18745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4U86_RS18760	COG3210	domain, Protein
E4U86_RS18765	COG2994	toxin metabolic process
E4U86_RS18770	COG2831	hemolysin activation secretion protein
E4U86_RS18790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U86_RS18805	COG4983	Phage plasmid primase, P4 family domain protein
E4U86_RS18830	COG0582	viral genome integration into host DNA
E4U86_RS18835	COG0542	response to heat
E4U86_RS18845	COG1278	Cold shock
E4U86_RS18850	COG0577	efflux transmembrane transporter activity
E4U86_RS18850	COG1136	(ABC) transporter
E4U86_RS18855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS18860	COG2990	Protein conserved in bacteria
E4U86_RS18865	COG3593	DNA synthesis involved in DNA repair
E4U86_RS18870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4U86_RS18875	COG2431	L-lysine efflux transmembrane transporter activity
E4U86_RS18885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U86_RS18890	COG0028	Belongs to the TPP enzyme family
E4U86_RS18895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4U86_RS18900	COG0702	epimerase
E4U86_RS18905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U86_RS18910	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4U86_RS18930	COG1126	abc transporter atp-binding protein
E4U86_RS18935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS18940	COG4215	(ABC) transporter
E4U86_RS18945	COG4160	amino acid transport
E4U86_RS18950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS18980	COG1177	transmembrane transport
E4U86_RS18985	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4U86_RS18990	COG3842	ATPase activity
E4U86_RS18995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U86_RS19010	COG0778	Nitroreductase
E4U86_RS19020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U86_RS19035	COG3226	Transcriptional regulator
E4U86_RS19040	COG0738	Major facilitator superfamily
E4U86_RS19045	COG0561	phosphatase activity
E4U86_RS19055	COG2814	Major facilitator Superfamily
E4U86_RS19060	COG0671	phosphoesterase, PA-phosphatase related
E4U86_RS19065	COG1349	DNA-binding transcription factor activity
E4U86_RS19070	COG1686	Belongs to the peptidase S11 family
E4U86_RS19075	COG0625	glutathione transferase activity
E4U86_RS19080	COG2133	pyrroloquinoline quinone binding
E4U86_RS19105	COG2199	diguanylate cyclase activity
E4U86_RS19110	COG2200	EAL domain
E4U86_RS19120	COG0601	transmembrane transport
E4U86_RS19125	COG0747	negative chemotaxis
E4U86_RS19130	COG4172	Belongs to the ABC transporter superfamily
E4U86_RS19140	COG0303	'Molybdopterin
E4U86_RS19145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4U86_RS19150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U86_RS19155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U86_RS19165	COG0561	phosphatase activity
E4U86_RS19175	COG0488	(ABC) transporter
E4U86_RS19180	COG1376	ErfK ybiS ycfS ynhG family protein
E4U86_RS19185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4U86_RS19190	COG1321	iron dependent repressor
E4U86_RS19200	COG2194	sulfuric ester hydrolase activity
E4U86_RS19205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4U86_RS19215	COG5006	permease, DMT superfamily
E4U86_RS19225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS19230	COG0765	amino acid transport
E4U86_RS19235	COG1126	abc transporter atp-binding protein
E4U86_RS19240	COG0668	transmembrane transport
E4U86_RS19255	COG4774	siderophore transport
E4U86_RS19265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4U86_RS19275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4U86_RS19280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4U86_RS19285	COG1199	ATP-dependent helicase activity
E4U86_RS19295	COG0513	Belongs to the DEAD box helicase family
E4U86_RS19300	COG1309	transcriptional regulator
E4U86_RS19310	COG1131	(ABC) transporter
E4U86_RS19315	COG0842	Transport permease protein
E4U86_RS19320	COG0842	Transport permease protein
E4U86_RS19330	COG3568	Endonuclease Exonuclease Phosphatase
E4U86_RS19335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U86_RS19340	COG0392	lysyltransferase activity
E4U86_RS19345	COG0670	Belongs to the BI1 family
E4U86_RS19350	COG0670	Belongs to the BI1 family
E4U86_RS19355	COG0314	molybdopterin synthase activity
E4U86_RS19360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4U86_RS19370	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4U86_RS19380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4U86_RS19390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4U86_RS19395	COG2226	methyltransferase
E4U86_RS19410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4U86_RS19415	COG1881	PFAM PEBP family protein
E4U86_RS19455	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS19530	COG0740	serine-type endopeptidase activity
E4U86_RS19570	COG3772	lysozyme
E4U86_RS19685	COG0582	viral genome integration into host DNA
E4U86_RS19690	COG4677	pectinesterase activity
E4U86_RS19695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4U86_RS19700	COG0471	metal ion transport
E4U86_RS19705	COG2828	Protein conserved in bacteria
E4U86_RS19710	COG0583	DNA-binding transcription factor activity
E4U86_RS19720	COG0561	phosphatase activity
E4U86_RS19730	COG4149	molybdate abc transporter
E4U86_RS19735	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4U86_RS19745	COG2005	Transcriptional regulator
E4U86_RS19745	COG3585	molybdate ion transport
E4U86_RS19750	COG1119	ATPase activity
E4U86_RS19755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4U86_RS19760	COG1085	galactose-1-phosphate uridylyltransferase
E4U86_RS19770	COG2017	converts alpha-aldose to the beta-anomer
E4U86_RS19780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U86_RS19790	COG1230	cation diffusion facilitator family transporter
E4U86_RS19795	COG3201	nicotinamide mononucleotide transporter
E4U86_RS19800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4U86_RS19830	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4U86_RS19835	COG2885	chlorophyll binding
E4U86_RS19845	COG3064	Membrane
E4U86_RS19850	COG0848	biopolymer transport protein
E4U86_RS19855	COG0811	peptide transport
E4U86_RS19860	COG0824	Thioesterase
E4U86_RS19865	COG3790	cyd operon protein YbgE
E4U86_RS19870	COG4890	Cyd operon protein YbgT
E4U86_RS19875	COG1294	oxidase, subunit
E4U86_RS19880	COG1271	oxidase subunit
E4U86_RS19895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U86_RS19905	COG4865	methylaspartate mutase activity
E4U86_RS19910	COG3799	methylaspartate ammonia-lyase activity
E4U86_RS19925	COG1301	dicarboxylic acid transport
E4U86_RS19930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS19930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS19935	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4U86_RS19940	COG0583	DNA-binding transcription factor activity
E4U86_RS19945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U86_RS19955	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4U86_RS19960	COG0567	Dehydrogenase, E1 component
E4U86_RS19965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4U86_RS19970	COG1053	succinate dehydrogenase
E4U86_RS19975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4U86_RS19980	COG2009	succinate dehydrogenase
E4U86_RS19990	COG0372	Belongs to the citrate synthase family
E4U86_RS19995	COG3539	Fimbrial protein
E4U86_RS20000	COG3188	usher protein
E4U86_RS20005	COG3121	Chaperone
E4U86_RS20010	COG3539	Fimbrial protein
E4U86_RS20015	COG3180	Ammonia monooxygenase
E4U86_RS20020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4U86_RS20030	COG1984	allophanate hydrolase subunit 2
E4U86_RS20035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4U86_RS20040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4U86_RS20045	COG3104	oligopeptide transport
E4U86_RS20050	COG0415	Belongs to the DNA photolyase family
E4U86_RS20055	COG3272	Protein of unknown function (DUF1722)
E4U86_RS20075	COG3209	COG3209 Rhs family protein
E4U86_RS20105	COG2205	protein histidine kinase activity
E4U86_RS20110	COG0745	RESPONSE REGULATOR receiver
E4U86_RS20120	COG1982	Orn Lys Arg decarboxylase major
E4U86_RS20125	COG0531	amino acid
E4U86_RS20130	COG0033	Phosphoglucomutase
E4U86_RS20135	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4U86_RS20140	COG0596	Alpha beta hydrolase
E4U86_RS20150	COG0716	FMN binding
E4U86_RS20160	COG0735	belongs to the Fur family
E4U86_RS20180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS20180	COG1263	PTS System
E4U86_RS20180	COG2190	(PTS) system
E4U86_RS20190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U86_RS20195	COG1940	carbohydrate kinase activity
E4U86_RS20195	COG1846	Transcriptional regulator
E4U86_RS20200	COG0647	UMP catabolic process
E4U86_RS20205	COG0367	asparagine synthase
E4U86_RS20245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U86_RS20255	COG1702	phosphate starvation-inducible protein PhoH
E4U86_RS20265	COG4535	Mg2 and Co2 transporter CorC
E4U86_RS20270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4U86_RS20275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U86_RS20280	COG0765	amino acid transport
E4U86_RS20285	COG0765	amino acid transport
E4U86_RS20290	COG1126	abc transporter atp-binding protein
E4U86_RS20300	COG0443	Heat shock 70 kDa protein
E4U86_RS20315	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U86_RS20320	COG2214	Heat shock protein DnaJ domain protein
E4U86_RS20335	COG2888	peptidyl-tyrosine sulfation
E4U86_RS20350	COG1466	dna polymerase III delta subunit
E4U86_RS20360	COG0406	alpha-ribazole phosphatase activity
E4U86_RS20365	COG0799	negative regulation of ribosome biogenesis
E4U86_RS20375	COG0768	penicillin binding
E4U86_RS20380	COG0772	Belongs to the SEDS family
E4U86_RS20385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4U86_RS20390	COG1686	Belongs to the peptidase S11 family
E4U86_RS20405	COG0583	DNA-binding transcription factor activity
E4U86_RS20415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U86_RS20420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U86_RS20440	COG3069	C4-dicarboxylate transmembrane transporter activity
E4U86_RS20445	COG4565	transcriptional regulatory protein
E4U86_RS20450	COG3290	protein histidine kinase activity
E4U86_RS20455	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4U86_RS20465	COG2301	Belongs to the HpcH HpaI aldolase family
E4U86_RS20470	COG3051	citrate lyase alpha subunit
E4U86_RS20480	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4U86_RS20485	COG0471	metal ion transport
E4U86_RS20490	COG3719	Belongs to the RNase T2 family
E4U86_RS20495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U86_RS20500	COG1063	alcohol dehydrogenase
E4U86_RS20505	COG0589	response to stress
E4U86_RS20510	COG3634	alkyl hydroperoxide reductase activity
E4U86_RS20515	COG0450	alkyl hydroperoxide reductase
E4U86_RS20520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U86_RS20525	COG0583	DNA-binding transcription factor activity
E4U86_RS20530	COG3969	phosphoadenosine phosphosulfate
E4U86_RS20535	COG1475	DNA binding
E4U86_RS20540	COG0436	Aminotransferase
E4U86_RS20545	COG0371	Dehydrogenase
E4U86_RS20550	COG2879	small protein
E4U86_RS20555	COG1966	Carbon starvation protein
E4U86_RS20565	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS20570	COG1535	isochorismatase
E4U86_RS20570	COG3433	isochorismatase activity
E4U86_RS20575	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4U86_RS20580	COG1169	isochorismate synthase
E4U86_RS20585	COG4592	Periplasmic binding protein
E4U86_RS20595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U86_RS20600	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U86_RS20605	COG1120	ATPase activity
E4U86_RS20610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4U86_RS20615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4U86_RS20615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4U86_RS20620	COG3251	PFAM MbtH domain protein
E4U86_RS20625	COG2382	esterase
E4U86_RS20630	COG4771	TonB-dependent receptor
E4U86_RS20635	COG2977	Belongs to the P-Pant transferase superfamily
E4U86_RS20660	COG2315	Protein conserved in bacteria
E4U86_RS20665	COG0778	Nitroreductase
E4U86_RS20670	COG0668	transmembrane transport
E4U86_RS20675	COG1113	amino acid transport
E4U86_RS20680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U86_RS20685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS20690	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS20695	COG1538	Outer membrane efflux protein
E4U86_RS20700	COG0745	RESPONSE REGULATOR receiver
E4U86_RS20705	COG5002	protein histidine kinase activity
E4U86_RS20710	COG3501	Rhs element vgr protein
E4U86_RS20720	COG4104	PAAR repeat-containing protein
E4U86_RS20720	COG3209	COG3209 Rhs family protein
E4U86_RS20730	COG3209	COG3209 Rhs family protein
E4U86_RS20730	COG4104	PAAR repeat-containing protein
E4U86_RS20740	COG5433	transposase activity
E4U86_RS20745	COG1215	transferase activity, transferring glycosyl groups
E4U86_RS20750	COG4783	chaperone-mediated protein folding
E4U86_RS20760	COG2207	Transcriptional regulator
E4U86_RS20770	COG2197	response regulator
E4U86_RS20775	COG3539	Fimbrial protein
E4U86_RS20780	COG3539	Fimbrial protein
E4U86_RS20785	COG3188	usher protein
E4U86_RS20790	COG3121	Chaperone
E4U86_RS20795	COG3539	Fimbrial protein
E4U86_RS20805	COG2501	S4 domain
E4U86_RS20810	COG1988	membrane-bound metal-dependent
E4U86_RS20820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4U86_RS20830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4U86_RS20835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4U86_RS20840	COG0549	Belongs to the carbamate kinase family
E4U86_RS20850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U86_RS20855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U86_RS20860	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4U86_RS20865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4U86_RS20870	COG3257	ureidoglycine aminohydrolase activity
E4U86_RS20875	COG1929	Belongs to the glycerate kinase type-1 family
E4U86_RS20880	COG2233	PERMEase
E4U86_RS20895	COG2084	Dehydrogenase
E4U86_RS20900	COG3622	Belongs to the hyi family
E4U86_RS20905	COG3960	tartronate-semialdehyde synthase activity
E4U86_RS20910	COG1414	Transcriptional regulator
E4U86_RS20920	COG0583	DNA-binding transcription factor activity
E4U86_RS20940	COG3209	COG3209 Rhs family protein
E4U86_RS20945	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4U86_RS20950	COG4181	ATPase activity
E4U86_RS20955	COG2755	lipolytic protein G-D-S-L family
E4U86_RS20960	COG0300	oxidoreductase activity
E4U86_RS20965	COG3118	belongs to the thioredoxin family
E4U86_RS20970	COG0390	transport system, permease component
E4U86_RS20975	COG4619	ABC transporter
E4U86_RS20980	COG0330	HflC and HflK could
E4U86_RS20985	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4U86_RS21005	COG0789	Transcriptional regulator
E4U86_RS21030	COG0531	amino acid
E4U86_RS21035	COG2066	Belongs to the glutaminase family
E4U86_RS21040	COG2217	Heavy metal translocating P-type atpase
E4U86_RS21045	COG3093	addiction module antidote protein HigA
E4U86_RS21050	COG3735	TraB family
E4U86_RS21055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4U86_RS21060	COG0737	Belongs to the 5'-nucleotidase family
E4U86_RS21065	COG2223	nitrite transmembrane transporter activity
E4U86_RS21070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4U86_RS21070	COG4651	solute:proton antiporter activity
E4U86_RS21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS21110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4U86_RS21120	COG2832	Protein of unknown function (DUF454)
E4U86_RS21125	COG3923	Primosomal replication protein n
E4U86_RS21135	COG3264	Mechanosensitive ion channel
E4U86_RS21135	COG1196	nuclear chromosome segregation
E4U86_RS21140	COG1309	transcriptional regulator
E4U86_RS21145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U86_RS21150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U86_RS21165	COG0110	maltose O-acetyltransferase activity
E4U86_RS21175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4U86_RS21180	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4U86_RS21190	COG3695	enzyme binding
E4U86_RS21195	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E4U86_RS21200	COG1946	Acyl-CoA thioesterase
E4U86_RS21205	COG0004	ammonium transporteR
E4U86_RS21210	COG0347	Belongs to the P(II) protein family
E4U86_RS21215	COG1132	(ABC) transporter
E4U86_RS21220	COG1132	(ABC) transporter
E4U86_RS21225	COG1522	sequence-specific DNA binding
E4U86_RS21235	COG4533	DNA binding
E4U86_RS21245	COG0824	Thioesterase
E4U86_RS21250	COG1555	photosystem II stabilization
E4U86_RS21255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U86_RS21260	COG0776	regulation of translation
E4U86_RS21265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4U86_RS21285	COG0271	Belongs to the BolA IbaG family
E4U86_RS21290	COG3056	Lipoprotein
E4U86_RS21295	COG2223	nitrite transmembrane transporter activity
E4U86_RS21300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4U86_RS21305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4U86_RS21310	COG1845	cytochrome c oxidase, subunit III
E4U86_RS21315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4U86_RS21325	COG2814	Major facilitator Superfamily
E4U86_RS21335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4U86_RS21340	COG0693	protein deglycase activity
E4U86_RS21355	COG0142	geranyltranstransferase activity
E4U86_RS21365	COG0667	Aldo Keto reductase
E4U86_RS21375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4U86_RS21380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4U86_RS21395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4U86_RS21395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4U86_RS21405	COG4238	major outer membrane lipoprotein
E4U86_RS21410	COG3248	Nucleoside-binding outer membrane protein
E4U86_RS21415	COG1403	HNH endonuclease
E4U86_RS21425	COG3609	addiction module antidote protein, CC2985 family
E4U86_RS21430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4U86_RS21435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4U86_RS21440	COG1862	Preprotein translocase
E4U86_RS21465	COG0366	Alpha amylase catalytic
E4U86_RS21470	COG1113	amino acid transport
E4U86_RS21475	COG1114	Component of the transport system for branched-chain amino acids
E4U86_RS21480	COG5002	protein histidine kinase activity
E4U86_RS21485	COG0745	RESPONSE REGULATOR receiver
E4U86_RS21490	COG0420	3'-5' exonuclease activity
E4U86_RS21495	COG0419	ATPase involved in DNA repair
E4U86_RS21500	COG2814	Major facilitator Superfamily
E4U86_RS21505	COG1940	carbohydrate kinase activity
E4U86_RS21530	COG4126	flavin adenine dinucleotide binding
E4U86_RS21550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4U86_RS21555	COG3706	GGDEF domain
E4U86_RS21565	COG1785	Belongs to the alkaline phosphatase family
E4U86_RS21580	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4U86_RS21600	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4U86_RS21605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U86_RS21610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U86_RS21615	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS21620	COG0113	porphobilinogen synthase activity
E4U86_RS21625	COG2175	clavaminate synthase activity
E4U86_RS21630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4U86_RS21635	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4U86_RS21640	COG4521	taurine ABC transporter
E4U86_RS21655	COG2271	Major facilitator Superfamily
E4U86_RS21660	COG1840	ABC-type Fe3 transport system, periplasmic component
E4U86_RS21670	COG3842	ATPase activity
E4U86_RS21685	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4U86_RS21690	COG3122	Protein conserved in bacteria
E4U86_RS21695	COG2814	Major facilitator Superfamily
E4U86_RS21700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4U86_RS21715	COG0596	Alpha beta hydrolase
E4U86_RS21730	COG1414	Transcriptional regulator
E4U86_RS21735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4U86_RS21745	COG1609	Transcriptional regulator
E4U86_RS21750	COG3250	beta-galactosidase activity
E4U86_RS21755	COG2223	nitrite transmembrane transporter activity
E4U86_RS21760	COG0110	maltose O-acetyltransferase activity
E4U86_RS21765	COG2807	transmembrane transport
E4U86_RS21775	COG0288	reversible hydration of carbon dioxide
E4U86_RS21780	COG0583	DNA-binding transcription factor activity
E4U86_RS21785	COG0402	S-adenosylhomocysteine deaminase activity
E4U86_RS21790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4U86_RS21795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4U86_RS21800	COG2079	MmgE PrpD family protein
E4U86_RS21805	COG0372	Belongs to the citrate synthase family
E4U86_RS21810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4U86_RS21815	COG3829	transcription factor binding
E4U86_RS21825	COG1280	lysine exporter protein (LysE YggA)
E4U86_RS21840	COG1064	alcohol dehydrogenase
E4U86_RS21850	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS21860	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS21870	COG0402	S-adenosylhomocysteine deaminase activity
E4U86_RS21875	COG0549	Belongs to the carbamate kinase family
E4U86_RS21885	COG1304	FMN binding
E4U86_RS21890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U86_RS21900	COG0666	response to abiotic stimulus
E4U86_RS21915	COG2771	luxR family
E4U86_RS21915	COG2200	EAL domain
E4U86_RS21925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4U86_RS21960	COG2200	EAL domain
E4U86_RS21960	COG2771	luxR family
E4U86_RS21985	COG1556	Lactate utilization protein
E4U86_RS21990	COG1139	Iron-sulfur cluster binding protein
E4U86_RS21995	COG0247	lactate metabolic process
E4U86_RS22000	COG2207	Transcriptional regulator
E4U86_RS22005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U86_RS22015	COG3059	membrane
E4U86_RS22020	COG0656	L-ascorbic acid biosynthetic process
E4U86_RS22025	COG3708	Transcriptional regulator
E4U86_RS22025	COG2207	Transcriptional regulator
E4U86_RS22045	COG0583	DNA-binding transcription factor activity
E4U86_RS22050	COG1073	alpha beta
E4U86_RS22055	COG1902	pentaerythritol trinitrate reductase activity
E4U86_RS22065	COG4372	Transposase
E4U86_RS22070	COG3436	PFAM IS66 Orf2 family protein
E4U86_RS22110	COG3188	usher protein
E4U86_RS22120	COG3121	Chaperone
E4U86_RS22125	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4U86_RS22130	COG3477	response to acidic pH
E4U86_RS22135	COG2080	2 iron, 2 sulfur cluster binding
E4U86_RS22140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U86_RS22145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U86_RS22150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4U86_RS22165	COG0583	DNA-binding transcription factor activity
E4U86_RS22175	COG4221	oxidoreductase activity
E4U86_RS22180	COG0583	DNA-binding transcription factor activity
E4U86_RS22260	COG0582	viral genome integration into host DNA
E4U86_RS22280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U86_RS22290	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U86_RS22305	COG3778	Protein conserved in bacteria
E4U86_RS22310	COG3299	homolog of phage Mu protein gp47
E4U86_RS22330	COG4228	DNA circulation
E4U86_RS22350	COG4386	tail sheath protein
E4U86_RS22400	COG4626	Terminase
E4U86_RS22400	COG1802	Transcriptional regulator
E4U86_RS22450	COG0484	heat shock protein binding
E4U86_RS22455	COG1403	HNH endonuclease
E4U86_RS22465	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U86_RS22475	COG4725	Belongs to the MT-A70-like family
E4U86_RS22485	COG1846	Transcriptional regulator
E4U86_RS22515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4U86_RS22530	COG0582	viral genome integration into host DNA
E4U86_RS22550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U86_RS22570	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4U86_RS22575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4U86_RS22580	COG1690	Belongs to the RtcB family
E4U86_RS22585	COG0454	-acetyltransferase
E4U86_RS22595	COG2161	toxin-antitoxin pair type II binding
E4U86_RS22600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4U86_RS22620	COG0791	NLP P60 protein
E4U86_RS22625	COG3077	Addiction module antitoxin, RelB DinJ family
E4U86_RS22630	COG3041	Addiction module toxin RelE StbE family
E4U86_RS22635	COG3034	peptidoglycan biosynthetic process
E4U86_RS22640	COG0121	glutamine amidotransferase
E4U86_RS22650	COG1960	acyl-CoA dehydrogenase activity
E4U86_RS22660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U86_RS22665	COG5433	transposase activity
E4U86_RS22680	COG3209	COG3209 Rhs family protein
E4U86_RS22685	COG5433	transposase activity
E4U86_RS22695	COG3209	COG3209 Rhs family protein
E4U86_RS22710	COG3501	Rhs element vgr protein
E4U86_RS22825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U86_RS22835	COG2226	methyltransferase
E4U86_RS22845	COG0741	lytic transglycosylase activity
E4U86_RS22845	COG1388	LysM domain
E4U86_RS22850	COG2226	methyltransferase
E4U86_RS22860	COG0583	DNA-binding transcription factor activity
E4U86_RS22865	COG0656	L-ascorbic acid biosynthetic process
E4U86_RS22900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4U86_RS22905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4U86_RS22910	COG2011	ABC-type metal ion transport system permease component
E4U86_RS22915	COG1464	Belongs to the NlpA lipoprotein family
E4U86_RS22925	COG1720	tRNA m6t6A37 methyltransferase activity
E4U86_RS22935	COG0791	NLP P60 protein
E4U86_RS22940	COG3015	lipoprotein NlpE involved in copper resistance
E4U86_RS22945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4U86_RS22950	COG4681	YaeQ
E4U86_RS22960	COG4568	rho-dependent transcription termination
E4U86_RS22965	COG0037	tRNA processing
E4U86_RS22970	COG0346	lactoylglutathione lyase activity
E4U86_RS22985	COG0587	DNA-directed DNA polymerase activity
E4U86_RS23010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4U86_RS23015	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E4U86_RS23025	COG0750	zinc metalloprotease
E4U86_RS23030	COG0575	Belongs to the CDS family
E4U86_RS23035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4U86_RS23040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4U86_RS23065	COG0024	Methionine aminopeptidase
E4U86_RS23085	COG3835	regulator
E4U86_RS23090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U86_RS23105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4U86_RS23110	COG2860	membrane
E4U86_RS23135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U86_RS23140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4U86_RS23145	COG1120	ATPase activity
E4U86_RS23150	COG4774	siderophore transport
E4U86_RS23155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4U86_RS23160	COG1643	Atp-dependent helicase
E4U86_RS23165	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4U86_RS23175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4U86_RS23180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4U86_RS23185	COG0617	tRNA 3'-terminal CCA addition
E4U86_RS23190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4U86_RS23200	COG3121	Chaperone
E4U86_RS23205	COG3188	usher protein
E4U86_RS23210	COG3539	Fimbrial protein
E4U86_RS23215	COG3539	Fimbrial protein
E4U86_RS23240	COG5464	transposase or invertase
E4U86_RS23250	COG0726	polysaccharide deacetylase
E4U86_RS23255	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS23260	COG0842	Transport permease protein
E4U86_RS23265	COG1131	(ABC) transporter
E4U86_RS23270	COG0288	reversible hydration of carbon dioxide
E4U86_RS23275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4U86_RS23280	COG4993	Dehydrogenase
E4U86_RS23285	COG2132	Multicopper oxidase
E4U86_RS23310	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4U86_RS23315	COG3064	Membrane
E4U86_RS23320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U86_RS23325	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4U86_RS23330	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4U86_RS23335	COG2186	Transcriptional regulator
E4U86_RS23340	COG1113	amino acid transport
E4U86_RS23345	COG3725	Membrane protein required for beta-lactamase induction
E4U86_RS23350	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4U86_RS23355	COG0157	Belongs to the NadC ModD family
E4U86_RS23360	COG4969	Belongs to the N-Me-Phe pilin family
E4U86_RS23365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4U86_RS23370	COG1459	type II secretion system
E4U86_RS23380	COG0237	dephospho-CoA kinase activity
E4U86_RS23395	COG0494	nUDIX hydrolase
E4U86_RS23415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4U86_RS23420	COG0849	cell division
E4U86_RS23425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4U86_RS23430	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4U86_RS23445	COG0772	Belongs to the SEDS family
E4U86_RS23450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4U86_RS23460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4U86_RS23465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4U86_RS23470	COG0768	penicillin binding
E4U86_RS23475	COG3116	cell division
E4U86_RS23490	COG1609	Transcriptional regulator
E4U86_RS23500	COG0440	acetolactate synthase activity
E4U86_RS23505	COG0028	Belongs to the TPP enzyme family
E4U86_RS23510	COG0583	DNA-binding transcription factor activity
E4U86_RS23525	COG0473	3-isopropylmalate dehydrogenase activity
E4U86_RS23545	COG4533	DNA binding
E4U86_RS23555	COG4143	(ABC) transporter
E4U86_RS23560	COG1178	ABC-type Fe3 transport system permease component
E4U86_RS23565	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4U86_RS23570	COG0586	Pfam SNARE associated Golgi protein
E4U86_RS23575	COG4977	sequence-specific DNA binding
E4U86_RS23590	COG0235	Class ii aldolase
E4U86_RS23595	COG0417	DNA replication proofreading
E4U86_RS23605	COG0564	pseudouridine synthase activity
E4U86_RS23615	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U86_RS23620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4U86_RS23625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U86_RS23630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U86_RS23665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4U86_RS23680	COG2271	Major facilitator Superfamily
E4U86_RS23685	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U86_RS23690	COG0644	oxidoreductase
E4U86_RS23725	COG1024	Enoyl-CoA hydratase
E4U86_RS23740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4U86_RS23745	COG0505	Belongs to the CarA family
E4U86_RS23765	COG1047	Peptidyl-prolyl cis-trans
E4U86_RS23780	COG0196	riboflavin kinase activity
E4U86_RS23805	COG3121	Chaperone
E4U86_RS23810	COG3188	usher protein
E4U86_RS23820	COG0583	DNA-binding transcription factor activity
E4U86_RS23850	COG4735	regulation of single-species biofilm formation
E4U86_RS23855	COG1584	GPR1 FUN34 yaaH family protein
E4U86_RS23860	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4U86_RS23865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U86_RS23870	COG1115	amino acid carrier protein
E4U86_RS23885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4U86_RS23895	COG0527	aspartate kinase activity
E4U86_RS23895	COG0460	homoserine dehydrogenase
E4U86_RS23905	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4U86_RS23915	COG0745	RESPONSE REGULATOR receiver
E4U86_RS23920	COG4452	Inner membrane protein CreD
E4U86_RS23925	COG2205	protein histidine kinase activity
E4U86_RS23930	COG0745	RESPONSE REGULATOR receiver
E4U86_RS23935	COG3045	CreA protein
E4U86_RS23940	COG3708	Transcriptional regulator
E4U86_RS23940	COG2207	Transcriptional regulator
E4U86_RS23950	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E4U86_RS23960	COG0741	lytic transglycosylase activity
E4U86_RS23965	COG0488	(ABC) transporter
E4U86_RS23975	COG1056	cytidyltransferase-related domain
E4U86_RS23975	COG3172	ATPase kinase involved in NAD metabolism
E4U86_RS23980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4U86_RS23985	COG0560	Phosphoserine phosphatase
E4U86_RS23995	COG0095	Lipoate-protein ligase
E4U86_RS23995	COG3726	membrane protein affecting hemolysin expression
E4U86_RS24030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U86_RS24035	COG0084	hydrolase, TatD family'
E4U86_RS24040	COG4667	esterase of the alpha-beta hydrolase superfamily
E4U86_RS24050	COG2823	Periplasmic or secreted lipoprotein
E4U86_RS24060	COG1011	Hydrolase
E4U86_RS24065	COG0456	acetyltransferase
E4U86_RS24070	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E4U86_RS24090	COG4114	ferric iron reductase
E4U86_RS24095	COG2197	response regulator
E4U86_RS24100	COG2197	response regulator
E4U86_RS24105	COG2966	Psort location CytoplasmicMembrane, score
E4U86_RS24120	COG1484	DNA-dependent DNA replication
E4U86_RS24135	COG1063	alcohol dehydrogenase
E4U86_RS24140	COG1802	Transcriptional regulator
E4U86_RS24145	COG2271	Major facilitator Superfamily
E4U86_RS24150	COG0840	transmembrane signaling receptor activity
E4U86_RS24160	COG1966	Carbon starvation protein
E4U86_RS24165	COG2879	small protein
E4U86_RS24170	COG0523	cobalamin synthesis protein
E4U86_RS24195	COG0732	type I restriction modification DNA specificity domain
E4U86_RS24215	COG5457	Domain of unknown function (DUF1127)
E4U86_RS24220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4U86_RS24230	COG5464	transposase or invertase
E4U86_RS24235	COG2814	Major facilitator Superfamily
E4U86_RS24240	COG2733	membrane
E4U86_RS24245	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4U86_RS24250	COG1924	4 iron, 4 sulfur cluster binding
E4U86_RS24265	COG3204	pilus organization
E4U86_RS24270	COG0477	Major facilitator Superfamily
E4U86_RS24285	COG3366	ferrous iron transmembrane transporter activity
E4U86_RS24290	COG0700	Nucleoside recognition
E4U86_RS24295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U86_RS24320	COG2186	Transcriptional regulator
E4U86_RS24325	COG0246	Mannitol dehydrogenase
E4U86_RS24335	COG2610	gluconate transmembrane transporter activity
E4U86_RS24340	COG3539	Fimbrial protein
E4U86_RS24345	COG3539	Fimbrial protein
E4U86_RS24350	COG3539	Fimbrial protein
E4U86_RS24355	COG3188	usher protein
E4U86_RS24360	COG3121	Chaperone
E4U86_RS24365	COG3539	Fimbrial protein
E4U86_RS24370	COG3539	Fimbrial protein
E4U86_RS24375	COG4974	Belongs to the 'phage' integrase family
E4U86_RS24380	COG0582	viral genome integration into host DNA
E4U86_RS24385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U86_RS24390	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E4U86_RS24405	COG0210	DNA helicase
E4U86_RS24410	COG1111	helicase
E4U86_RS24410	COG1205	dead DEAH box helicase
E4U86_RS24420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U86_RS24465	COG0582	viral genome integration into host DNA
E4U86_RS24520	COG1064	alcohol dehydrogenase
E4U86_RS24525	COG0433	COG0433 Predicted ATPase
E4U86_RS24530	COG0795	lipopolysaccharide-transporting ATPase activity
E4U86_RS24535	COG0795	lipopolysaccharide-transporting ATPase activity
E4U86_RS24545	COG2927	DNA polymerase III (CHI subunit)
E4U86_RS24555	COG4269	membrane
E4U86_RS24560	COG0456	acetyltransferase
E4U86_RS24565	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4U86_RS24570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4U86_RS24580	COG2731	YhcH YjgK YiaL family protein
E4U86_RS24585	COG1309	transcriptional regulator
E4U86_RS24590	COG1028	Short-chain dehydrogenase reductase Sdr
E4U86_RS24595	COG0251	oxidation-reduction process
E4U86_RS24615	COG0251	oxidation-reduction process
E4U86_RS24620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4U86_RS24630	COG1609	Transcriptional regulator
E4U86_RS24635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U86_RS24635	COG1263	PTS System
E4U86_RS24640	COG0366	Alpha amylase catalytic
E4U86_RS24645	COG1328	CTP reductase activity
E4U86_RS24650	COG0602	queuosine metabolic process
E4U86_RS24655	COG3783	Cytochrome b(562)
E4U86_RS24660	COG0312	modulator of DNA gyrase
E4U86_RS24670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4U86_RS24680	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS24685	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS24690	COG1129	ABC transporter
E4U86_RS24695	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS24700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4U86_RS24705	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4U86_RS24710	COG2336	PFAM SpoVT AbrB
E4U86_RS24715	COG2105	PFAM AIG2 family protein
E4U86_RS24720	COG2911	Protein conserved in bacteria
E4U86_RS24725	COG0729	surface antigen
E4U86_RS24735	COG1253	flavin adenine dinucleotide binding
E4U86_RS24745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4U86_RS24755	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4U86_RS24760	COG0737	Belongs to the 5'-nucleotidase family
E4U86_RS24765	COG1733	regulation of RNA biosynthetic process
E4U86_RS24770	COG0702	epimerase
E4U86_RS24775	COG0697	spore germination
E4U86_RS24785	COG1113	amino acid transport
E4U86_RS24790	COG0545	Peptidyl-prolyl cis-trans isomerase
E4U86_RS24795	COG3061	Opacity-associated protein A
E4U86_RS24805	COG0675	Transposase, IS605 OrfB family
E4U86_RS24830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4U86_RS24865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS24870	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U86_RS24875	COG3037	sugar-specific permease SgaT UlaA
E4U86_RS24890	COG1073	alpha beta
E4U86_RS24895	COG3650	response to hydrogen peroxide
E4U86_RS24905	COG1960	acyl-CoA dehydrogenase activity
E4U86_RS24910	COG0754	glutathionylspermidine amidase activity
E4U86_RS24915	COG5463	Belongs to the UPF0441 family
E4U86_RS24920	COG3766	membrane
E4U86_RS24930	COG1842	Phage shock protein A
E4U86_RS24935	COG3789	protein conserved in bacteria
E4U86_RS24940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U86_RS24945	COG0557	exoribonuclease II activity
E4U86_RS24960	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4U86_RS24965	COG0330	HflC and HflK could
E4U86_RS24970	COG0330	HflC and HflK could
E4U86_RS24975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4U86_RS24995	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U86_RS25000	COG0802	atpase or kinase
E4U86_RS25005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4U86_RS25005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4U86_RS25040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4U86_RS25055	COG1511	domain protein
E4U86_RS25055	COG3264	Mechanosensitive ion channel
E4U86_RS25060	COG0531	amino acid
E4U86_RS25070	COG1053	succinate dehydrogenase
E4U86_RS25075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4U86_RS25090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U86_RS25095	COG3040	lipid binding
E4U86_RS25100	COG2076	Multidrug Resistance protein
E4U86_RS25105	COG5510	response to toxic substance
E4U86_RS25110	COG5510	response to toxic substance
E4U86_RS25120	COG1509	lysine 2,3-aminomutase activity
E4U86_RS25145	COG0531	amino acid
E4U86_RS25150	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4U86_RS25155	COG1027	Aspartate ammonia-lyase
E4U86_RS25160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4U86_RS25170	COG4232	protein-disulfide reductase activity
E4U86_RS25175	COG1309	transcriptional regulator
E4U86_RS25185	COG3710	Transcriptional regulator
E4U86_RS25190	COG0531	amino acid
E4U86_RS25195	COG1982	Orn Lys Arg decarboxylase major
E4U86_RS25200	COG3104	oligopeptide transport
E4U86_RS25205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4U86_RS25220	COG2388	GCN5-related N-acetyl-transferase
E4U86_RS25225	COG3592	Divergent 4Fe-4S mono-cluster
E4U86_RS25230	COG3290	protein histidine kinase activity
E4U86_RS25235	COG4565	transcriptional regulatory protein
E4U86_RS25240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4U86_RS25245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS25245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U86_RS25250	COG3647	Membrane
E4U86_RS25255	COG2211	Major facilitator Superfamily
E4U86_RS25260	COG1486	melibiose metabolic process
E4U86_RS25265	COG2169	Transcriptional regulator
E4U86_RS25270	COG1982	Orn Lys Arg decarboxylase major
E4U86_RS25275	COG2207	Transcriptional regulator
E4U86_RS25280	COG0531	amino acid
E4U86_RS25285	COG2194	sulfuric ester hydrolase activity
E4U86_RS25290	COG0745	RESPONSE REGULATOR receiver
E4U86_RS25295	COG0642	Histidine kinase
E4U86_RS25305	COG0477	Major facilitator Superfamily
E4U86_RS25315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4U86_RS25320	COG2824	Alkylphosphonate utilization operon protein PhnA
E4U86_RS25325	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4U86_RS25330	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4U86_RS25335	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4U86_RS25340	COG3639	organic phosphonate transmembrane transporter activity
E4U86_RS25345	COG2188	Transcriptional regulator
E4U86_RS25350	COG3624	Phosphonate C-P lyase system protein PhnG
E4U86_RS25355	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E4U86_RS25360	COG3626	phosphonate metabolism
E4U86_RS25365	COG3627	carbon phosphorus lyase activity
E4U86_RS25370	COG4107	phosphonate C-P lyase system protein PhnK
E4U86_RS25375	COG4778	phosphonate C-P lyase system protein PhnL
E4U86_RS25380	COG3454	Phosphonate metabolism
E4U86_RS25385	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4U86_RS25390	COG0456	acetyltransferase
E4U86_RS25395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4U86_RS25410	COG1129	ABC transporter
E4U86_RS25415	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS25435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS25445	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4U86_RS25455	COG1566	PFAM secretion protein HlyD family protein
E4U86_RS25460	COG1289	transmembrane transporter activity
E4U86_RS25465	COG1538	Outer membrane efflux protein
E4U86_RS25475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U86_RS25480	COG1301	dicarboxylic acid transport
E4U86_RS25485	COG4235	cytochrome complex assembly
E4U86_RS25490	COG3088	subunit of a heme lyase
E4U86_RS25495	COG1138	Cytochrome C-type biogenesis protein
E4U86_RS25500	COG3301	Polysulphide reductase, NrfD
E4U86_RS25505	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS25510	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4U86_RS25520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4U86_RS25525	COG3162	membrane
E4U86_RS25535	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U86_RS25540	COG0025	NhaP-type Na H and K H
E4U86_RS25545	COG2252	PERMEase
E4U86_RS25550	COG0789	Transcriptional regulator
E4U86_RS25555	COG2207	Transcriptional regulator
E4U86_RS25560	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4U86_RS25570	COG0629	single-stranded DNA binding
E4U86_RS25575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4U86_RS25580	COG2315	Protein conserved in bacteria
E4U86_RS25585	COG0432	Pfam Uncharacterised protein family UPF0047
E4U86_RS25590	COG3700	Belongs to the class B bacterial acid phosphatase family
E4U86_RS25600	COG1448	Aminotransferase
E4U86_RS25605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4U86_RS25610	COG0305	Participates in initiation and elongation during chromosome replication
E4U86_RS25615	COG0604	alcohol dehydrogenase
E4U86_RS25625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U86_RS25665	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U86_RS25730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U86_RS25740	COG0735	belongs to the Fur family
E4U86_RS25745	COG3237	CsbD-like
E4U86_RS25750	COG0534	Mate efflux family protein
E4U86_RS25760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4U86_RS25780	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U86_RS25795	COG3842	ATPase activity
E4U86_RS25800	COG2182	Extracellular solute-binding protein
E4U86_RS25805	COG1175	transmembrane transport
E4U86_RS25810	COG3833	ABC-type maltose transport systems, permease component
E4U86_RS25815	COG2814	Major facilitator Superfamily
E4U86_RS25815	COG0477	Major facilitator Superfamily
E4U86_RS25835	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U86_RS25860	COG0527	aspartate kinase activity
E4U86_RS25870	COG1187	pseudouridine synthase activity
E4U86_RS25915	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4U86_RS25920	COG1410	methionine synthase
E4U86_RS25920	COG0646	methionine synthase
E4U86_RS25925	COG1414	Transcriptional regulator
E4U86_RS25940	COG2224	Isocitrate lyase
E4U86_RS25945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4U86_RS25955	COG0456	acetyltransferase
E4U86_RS25985	COG0151	Belongs to the GarS family
E4U86_RS25990	COG2204	response regulator
E4U86_RS25995	COG4191	Histidine kinase
E4U86_RS26000	COG3678	ATP-independent chaperone mediated protein folding
E4U86_RS26015	COG3068	Protein conserved in bacteria
E4U86_RS26050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4U86_RS26055	COG2104	thiamine diphosphate biosynthetic process
E4U86_RS26060	COG2022	thiamine diphosphate biosynthetic process
E4U86_RS26065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4U86_RS26105	COG0250	Participates in transcription elongation, termination and antitermination
E4U86_RS26110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4U86_RS26145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4U86_RS26145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4U86_RS26150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4U86_RS26175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4U86_RS26180	COG4206	TonB-dependent receptor
E4U86_RS26185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4U86_RS26195	COG1309	transcriptional regulator
E4U86_RS26200	COG0477	Major facilitator Superfamily
E4U86_RS26205	COG1473	amidohydrolase
E4U86_RS26215	COG0583	DNA-binding transcription factor activity
E4U86_RS26230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4U86_RS26245	COG2194	sulfuric ester hydrolase activity
E4U86_RS26250	COG2207	Transcriptional regulator
E4U86_RS26255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS26260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U86_RS26265	COG1882	Formate acetyltransferase
E4U86_RS26270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS26275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS26280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U86_RS26280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS26280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS26285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U86_RS26290	COG0371	Dehydrogenase
E4U86_RS26295	COG3738	Protein conserved in bacteria
E4U86_RS26300	COG0697	spore germination
E4U86_RS26310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4U86_RS26315	COG0460	homoserine dehydrogenase
E4U86_RS26315	COG0527	aspartate kinase activity
E4U86_RS26320	COG0626	cystathionine gamma-synthase activity
E4U86_RS26330	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E4U86_RS26345	COG3209	COG3209 Rhs family protein
E4U86_RS26355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4U86_RS26360	COG1609	Transcriptional regulator
E4U86_RS26365	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4U86_RS26380	COG1575	Belongs to the MenA family. Type 1 subfamily
E4U86_RS26405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4U86_RS26415	COG1494	fructose-1,6-bisphosphatase
E4U86_RS26425	COG0589	response to stress
E4U86_RS26430	COG3691	Protein conserved in bacteria
E4U86_RS26435	COG3152	Membrane
E4U86_RS26455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4U86_RS26470	COG3678	ATP-independent chaperone mediated protein folding
E4U86_RS26475	COG0745	RESPONSE REGULATOR receiver
E4U86_RS26480	COG2205	protein histidine kinase activity
E4U86_RS26485	COG2258	MOSC domain
E4U86_RS26495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4U86_RS26505	COG4977	sequence-specific DNA binding
E4U86_RS26505	COG1917	Cupin 2, conserved barrel domain protein
E4U86_RS26540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS26545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS26545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U86_RS26550	COG1363	Peptidase, m42
E4U86_RS26555	COG3711	transcriptional antiterminator
E4U86_RS26555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U86_RS26575	COG0437	4 iron, 4 sulfur cluster binding
E4U86_RS26580	COG2864	formate dehydrogenase
E4U86_RS26590	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U86_RS26595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U86_RS26610	COG0456	acetyltransferase
E4U86_RS26625	COG1011	Hydrolase
E4U86_RS26630	COG1349	DNA-binding transcription factor activity
E4U86_RS26635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS26640	COG2084	Dehydrogenase
E4U86_RS26645	COG3684	Belongs to the aldolase LacD family
E4U86_RS26650	COG2942	2-epimerase
E4U86_RS26655	COG2017	converts alpha-aldose to the beta-anomer
E4U86_RS26665	COG1501	Belongs to the glycosyl hydrolase 31 family
E4U86_RS26670	COG2211	Major facilitator Superfamily
E4U86_RS26675	COG2211	Major facilitator Superfamily
E4U86_RS26680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U86_RS26685	COG2271	Major facilitator Superfamily
E4U86_RS26690	COG1082	Xylose isomerase domain protein TIM barrel
E4U86_RS26695	COG2188	Transcriptional regulator
E4U86_RS26705	COG0174	glutamine synthetase
E4U86_RS26710	COG3852	Histidine kinase
E4U86_RS26715	COG2204	response regulator
E4U86_RS26725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4U86_RS26730	COG3078	GTPase activator activity
E4U86_RS26740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4U86_RS26740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4U86_RS26745	COG0204	Acyl-transferase
E4U86_RS26750	COG5339	Protein conserved in bacteria
E4U86_RS26755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U86_RS26760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4U86_RS26765	COG3084	Protein conserved in bacteria
E4U86_RS26770	COG0746	molybdenum cofactor guanylyltransferase activity
E4U86_RS26775	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4U86_RS26805	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4U86_RS26810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4U86_RS26815	COG1739	Uncharacterized protein family UPF0029
E4U86_RS26830	COG0183	Belongs to the thiolase family
E4U86_RS26835	COG0543	2 iron, 2 sulfur cluster binding
E4U86_RS26840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4U86_RS26845	COG0250	Participates in transcription elongation, termination and antitermination
E4U86_RS26850	COG0084	hydrolase, TatD family'
E4U86_RS26855	COG0805	protein transport
E4U86_RS26860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U86_RS26865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U86_RS26875	COG3165	ubiquinone biosynthetic process from chorismate
E4U86_RS26885	COG1322	Protein conserved in bacteria
E4U86_RS26890	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4U86_RS26895	COG0412	Dienelactone hydrolase
E4U86_RS26905	COG0583	DNA-binding transcription factor activity
E4U86_RS26910	COG0697	spore germination
E4U86_RS26915	COG0561	phosphatase activity
E4U86_RS26920	COG2267	carboxylic ester hydrolase activity
E4U86_RS26925	COG1280	lysine exporter protein (LysE YggA)
E4U86_RS26930	COG1280	lysine exporter protein (LysE YggA)
E4U86_RS26935	COG0514	ATP-dependent DNA helicase (RecQ)
E4U86_RS26940	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E4U86_RS26945	COG2050	protein possibly involved in aromatic compounds catabolism
E4U86_RS26950	COG2962	Rard protein
E4U86_RS26975	COG0598	Magnesium transport protein CorA
E4U86_RS26980	COG3698	Phosphodiester glycosidase
E4U86_RS26985	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4U86_RS26990	COG0210	DNA helicase
E4U86_RS26995	COG1011	Hydrolase
E4U86_RS27005	COG3159	Protein conserved in bacteria
E4U86_RS27015	COG5567	small periplasmic lipoprotein
E4U86_RS27025	COG3072	Adenylate cyclase
E4U86_RS27035	COG1587	Uroporphyrinogen-III synthase
E4U86_RS27040	COG2959	enzyme of heme biosynthesis
E4U86_RS27045	COG3071	HemY protein
E4U86_RS27050	COG3119	arylsulfatase activity
E4U86_RS27055	COG0641	radical SAM
E4U86_RS27085	COG1113	amino acid transport
E4U86_RS27105	COG2244	polysaccharide biosynthetic process
E4U86_RS27110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4U86_RS27115	COG0456	acetyltransferase
E4U86_RS27120	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4U86_RS27125	COG1088	dTDP-glucose 4,6-dehydratase activity
E4U86_RS27130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4U86_RS27135	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4U86_RS27140	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4U86_RS27145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4U86_RS27150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4U86_RS27160	COG3118	belongs to the thioredoxin family
E4U86_RS27175	COG0210	DNA helicase
E4U86_RS27180	COG3692	DNA binding
E4U86_RS27185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U86_RS27195	COG0583	DNA-binding transcription factor activity
E4U86_RS27200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U86_RS27210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4U86_RS27215	COG3978	acetolactate synthase activity
E4U86_RS27235	COG0606	chelatase, subunit chli
E4U86_RS27240	COG3085	chromosome segregation
E4U86_RS27280	COG2186	Transcriptional regulator
E4U86_RS27285	COG0477	Major facilitator Superfamily
E4U86_RS27290	COG1609	Transcriptional regulator
E4U86_RS27295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U86_RS27300	COG1879	ABC-type sugar transport system periplasmic component
E4U86_RS27305	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U86_RS27310	COG1129	ABC transporter
E4U86_RS27320	COG3158	transport of potassium into the cell
E4U86_RS27340	COG1522	sequence-specific DNA binding
E4U86_RS27345	COG0716	FMN binding
E4U86_RS27435	COG2274	protein secretion by the type I secretion system
E4U86_RS27600	COG1475	DNA binding
E4U86_RS27685	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4U86_RS27695	COG1525	nuclease
E4U86_RS27775	COG3468	outer membrane autotransporter barrel domain protein
E4U86_RS27785	COG0726	polysaccharide deacetylase
E4U86_RS27790	COG0297	glycogen (starch) synthase activity
E4U86_RS27795	COG2194	sulfuric ester hydrolase activity
E4U86_RS27800	COG1560	Kdo2-lipid A biosynthetic process
E4U86_RS27805	COG4372	Transposase
E4U86_RS27810	COG3436	PFAM IS66 Orf2 family protein