locus-tag	class	description
E4T53_RS00015	COG3312	ion transport
E4T53_RS00065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4T53_RS00090	COG3539	Fimbrial protein
E4T53_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4T53_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E4T53_RS00110	COG0581	inorganic phosphate transmembrane transporter activity
E4T53_RS00115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T53_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
E4T53_RS00145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T53_RS00150	COG2252	PERMEase
E4T53_RS00155	COG0431	NADPH-dependent FMN reductase
E4T53_RS00160	COG2091	lysine biosynthetic process via aminoadipic acid
E4T53_RS00175	COG0814	amino acid
E4T53_RS00230	COG0592	DNA-directed DNA polymerase activity
E4T53_RS00240	COG0187	DNA topoisomerase II activity
E4T53_RS00245	COG3753	Protein conserved in bacteria
E4T53_RS00250	COG0561	phosphatase activity
E4T53_RS00260	COG0644	oxidoreductase
E4T53_RS00265	COG0823	Involved in the tonB-independent uptake of proteins
E4T53_RS00270	COG5645	(Lipo)protein
E4T53_RS00290	COG2188	Transcriptional regulator
E4T53_RS00305	COG2207	Transcriptional regulator
E4T53_RS00310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T53_RS00315	COG3119	arylsulfatase activity
E4T53_RS00325	COG2149	membrane
E4T53_RS00335	COG0641	radical SAM
E4T53_RS00340	COG2814	Major facilitator Superfamily
E4T53_RS00355	COG0028	Belongs to the TPP enzyme family
E4T53_RS00360	COG0440	acetolactate synthase activity
E4T53_RS00380	COG2197	response regulator
E4T53_RS00385	COG3851	Histidine kinase
E4T53_RS00390	COG2271	Major facilitator Superfamily
E4T53_RS00395	COG2271	Major facilitator Superfamily
E4T53_RS00425	COG2814	Major facilitator Superfamily
E4T53_RS00435	COG1464	Belongs to the NlpA lipoprotein family
E4T53_RS00440	COG0697	spore germination
E4T53_RS00445	COG2814	Major facilitator Superfamily
E4T53_RS00610	COG5492	domain, Protein
E4T53_RS00665	COG4372	Transposase
E4T53_RS00670	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS00715	COG0582	viral genome integration into host DNA
E4T53_RS00725	COG2211	Major facilitator Superfamily
E4T53_RS00730	COG1501	Belongs to the glycosyl hydrolase 31 family
E4T53_RS00735	COG2982	Protein involved in outer membrane biogenesis
E4T53_RS00740	COG2233	PERMEase
E4T53_RS00745	COG0786	glutamate:sodium symporter activity
E4T53_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4T53_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T53_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T53_RS00775	COG0194	GDP metabolic process
E4T53_RS00785	COG2860	membrane
E4T53_RS00790	COG3645	SOS response
E4T53_RS00795	COG1561	YicC-like family, N-terminal region
E4T53_RS00820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4T53_RS00850	COG1519	Transferase
E4T53_RS00855	COG0859	PFAM glycosyl transferase family 9
E4T53_RS00860	COG0438	transferase activity, transferring glycosyl groups
E4T53_RS00865	COG0515	serine threonine protein kinase
E4T53_RS00875	COG3642	lipopolysaccharide core region biosynthetic process
E4T53_RS00895	COG0859	PFAM glycosyl transferase family 9
E4T53_RS00900	COG0859	PFAM glycosyl transferase family 9
E4T53_RS00915	COG0156	8-amino-7-oxononanoate synthase activity
E4T53_RS00925	COG1216	Glycosyl transferase, family 2
E4T53_RS00930	COG2861	carbohydrate metabolic process
E4T53_RS00935	COG4942	peptidase
E4T53_RS00945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T53_RS00950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4T53_RS00965	COG1045	serine acetyltransferase
E4T53_RS00970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4T53_RS00980	COG2186	Transcriptional regulator
E4T53_RS00985	COG1620	l-lactate permease
E4T53_RS00990	COG5295	Hep Hag repeat protein
E4T53_RS01010	COG3722	fumarate hydratase activity
E4T53_RS01020	COG2213	PTS system mannitol-specific
E4T53_RS01020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS01030	COG1566	PFAM secretion protein HlyD family protein
E4T53_RS01040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4T53_RS01045	COG3209	COG3209 Rhs family protein
E4T53_RS01050	COG0625	glutathione transferase activity
E4T53_RS01060	COG3276	selenocysteine insertion sequence binding
E4T53_RS01065	COG1454	alcohol dehydrogenase
E4T53_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS01085	COG1566	PFAM secretion protein HlyD family protein
E4T53_RS01090	COG0583	DNA-binding transcription factor activity
E4T53_RS01095	COG3713	MltA-interacting MipA family protein
E4T53_RS01105	COG2211	Major facilitator Superfamily
E4T53_RS01115	COG1414	Transcriptional regulator
E4T53_RS01120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS01125	COG3977	Valine--pyruvate aminotransferase
E4T53_RS01130	COG0366	Alpha amylase catalytic
E4T53_RS01140	COG2992	FlgJ-related protein
E4T53_RS01145	COG2207	Transcriptional regulator
E4T53_RS01145	COG1609	Transcriptional regulator
E4T53_RS01150	COG4214	carbohydrate transport
E4T53_RS01160	COG4213	ABC transporter substrate-binding protein
E4T53_RS01170	COG1070	Carbohydrate kinase
E4T53_RS01175	COG4682	membrane
E4T53_RS01180	COG4682	membrane
E4T53_RS01185	COG3274	enterobacterial common antigen metabolic process
E4T53_RS01210	COG1278	Cold shock
E4T53_RS01215	COG2944	sequence-specific DNA binding
E4T53_RS01230	COG2885	chlorophyll binding
E4T53_RS01235	COG0243	molybdopterin cofactor binding
E4T53_RS01240	COG0456	acetyltransferase
E4T53_RS01245	COG2818	Glycosylase
E4T53_RS01250	COG5571	outer membrane autotransporter
E4T53_RS01255	COG2223	nitrite transmembrane transporter activity
E4T53_RS01260	COG3539	Fimbrial protein
E4T53_RS01265	COG3121	Chaperone
E4T53_RS01275	COG3539	Fimbrial protein
E4T53_RS01280	COG3539	Fimbrial protein
E4T53_RS01285	COG2194	sulfuric ester hydrolase activity
E4T53_RS01295	COG0747	negative chemotaxis
E4T53_RS01300	COG0601	transmembrane transport
E4T53_RS01305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T53_RS01310	COG0444	Belongs to the ABC transporter superfamily
E4T53_RS01315	COG4608	Belongs to the ABC transporter superfamily
E4T53_RS01320	COG0814	amino acid
E4T53_RS01330	COG2194	sulfuric ester hydrolase activity
E4T53_RS01360	COG1215	transferase activity, transferring glycosyl groups
E4T53_RS01365	COG1215	transferase activity, transferring glycosyl groups
E4T53_RS01370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4T53_RS01375	COG0457	Tetratricopeptide repeat
E4T53_RS01375	COG3118	belongs to the thioredoxin family
E4T53_RS01380	COG2200	EAL domain
E4T53_RS01380	COG2199	diguanylate cyclase activity
E4T53_RS01390	COG0612	Peptidase, M16
E4T53_RS01400	COG2200	EAL domain
E4T53_RS01405	COG2982	Protein involved in outer membrane biogenesis
E4T53_RS01410	COG0477	Major facilitator Superfamily
E4T53_RS01415	COG1295	ribonuclease BN
E4T53_RS01420	COG0583	DNA-binding transcription factor activity
E4T53_RS01425	COG2197	response regulator
E4T53_RS01435	COG1858	cytochrome C peroxidase
E4T53_RS01440	COG0076	glutamate decarboxylase activity
E4T53_RS01445	COG2207	Transcriptional regulator
E4T53_RS01450	COG2207	Transcriptional regulator
E4T53_RS01455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T53_RS01460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS01470	COG2771	luxR family
E4T53_RS01475	COG3247	response to pH
E4T53_RS01490	COG1285	pathogenesis
E4T53_RS01495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4T53_RS01500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T53_RS01510	COG3721	Heme iron utilization protein
E4T53_RS01520	COG4558	Periplasmic binding protein
E4T53_RS01530	COG4771	TonB-dependent receptor
E4T53_RS01535	COG3720	iron ion transport
E4T53_RS01540	COG2197	response regulator
E4T53_RS01545	COG3065	identical protein binding
E4T53_RS01555	COG1393	Belongs to the ArsC family
E4T53_RS01560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4T53_RS01565	COG0640	Transcriptional regulator
E4T53_RS01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T53_RS01580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4T53_RS01585	COG0339	signal peptide processing
E4T53_RS01595	COG3104	oligopeptide transport
E4T53_RS01600	COG0589	response to stress
E4T53_RS01610	COG0306	phosphate transporter
E4T53_RS01615	COG2081	HI0933 family
E4T53_RS01635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS01640	COG1129	ABC transporter
E4T53_RS01640	COG0842	Transport permease protein
E4T53_RS01645	COG0842	Transport permease protein
E4T53_RS01660	COG0191	fructose-bisphosphate aldolase activity
E4T53_RS01675	COG3775	system Galactitol-specific IIC component
E4T53_RS01680	COG3414	Phosphotransferase system galactitol-specific IIB component
E4T53_RS01690	COG2188	Transcriptional regulator
E4T53_RS01700	COG1124	(ABC) transporter
E4T53_RS01705	COG0444	Belongs to the ABC transporter superfamily
E4T53_RS01710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T53_RS01715	COG0601	transmembrane transport
E4T53_RS01720	COG0747	negative chemotaxis
E4T53_RS01725	COG2091	lysine biosynthetic process via aminoadipic acid
E4T53_RS01730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T53_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS01745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T53_RS01770	COG1216	Glycosyl transferase, family 2
E4T53_RS01790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T53_RS01800	COG0204	Acyl-transferase
E4T53_RS01820	COG0628	permease
E4T53_RS01835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4T53_RS01850	COG3714	YhhN family
E4T53_RS01860	COG3776	membrane
E4T53_RS01865	COG0742	ribosomal rna small subunit methyltransferase
E4T53_RS01870	COG0552	protein localization to endoplasmic reticulum
E4T53_RS01875	COG2884	Cell division ATP-binding protein ftsE
E4T53_RS01880	COG2177	Part of the ABC transporter FtsEX involved in
E4T53_RS01885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4T53_RS01890	COG0683	leucine binding
E4T53_RS01905	COG0456	acetyltransferase
E4T53_RS01910	COG0683	leucine binding
E4T53_RS01915	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS01920	COG4177	L-phenylalanine transmembrane transporter activity
E4T53_RS01925	COG0411	ABC transporter
E4T53_RS01930	COG0410	ABC transporter
E4T53_RS01940	COG1653	transport
E4T53_RS01945	COG1175	transmembrane transport
E4T53_RS01955	COG3842	ATPase activity
E4T53_RS01960	COG0584	glycerophosphoryl diester phosphodiesterase
E4T53_RS01970	COG0405	Gamma-glutamyltransferase
E4T53_RS01980	COG1247	-acetyltransferase
E4T53_RS01985	COG0673	inositol 2-dehydrogenase activity
E4T53_RS01990	COG1741	Belongs to the pirin family
E4T53_RS01995	COG1609	Transcriptional regulator
E4T53_RS02000	COG3265	gluconokinase activity
E4T53_RS02005	COG2610	gluconate transmembrane transporter activity
E4T53_RS02010	COG0514	ATP-dependent DNA helicase (RecQ)
E4T53_RS02030	COG2095	MarC family integral membrane protein
E4T53_RS02035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4T53_RS02040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4T53_RS02060	COG0058	SHG alpha-glucan phosphorylase activity
E4T53_RS02065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4T53_RS02080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4T53_RS02095	COG1349	DNA-binding transcription factor activity
E4T53_RS02100	COG4650	regulator
E4T53_RS02130	COG0058	SHG alpha-glucan phosphorylase activity
E4T53_RS02135	COG1640	4-alpha-glucanotransferase
E4T53_RS02140	COG2610	gluconate transmembrane transporter activity
E4T53_RS02150	COG1040	competence protein
E4T53_RS02160	COG5464	transposase or invertase
E4T53_RS02170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4T53_RS02175	COG1918	ferrous iron import across plasma membrane
E4T53_RS02180	COG2183	response to ionizing radiation
E4T53_RS02185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T53_RS02190	COG0745	RESPONSE REGULATOR receiver
E4T53_RS02195	COG2205	protein histidine kinase activity
E4T53_RS02205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4T53_RS02215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4T53_RS02220	COG1011	Hydrolase
E4T53_RS02230	COG0494	nUDIX hydrolase
E4T53_RS02235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4T53_RS02240	COG4972	Pilus assembly protein
E4T53_RS02245	COG3166	PFAM Fimbrial assembly family protein
E4T53_RS02260	COG4796	Type ii and iii secretion system protein
E4T53_RS02275	COG3266	domain, Protein
E4T53_RS02280	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4T53_RS02285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4T53_RS02290	COG0546	phosphoglycolate phosphatase activity
E4T53_RS02295	COG0180	Tryptophanyl-tRNA synthetase
E4T53_RS02300	COG2188	Transcriptional regulator
E4T53_RS02310	COG1082	Xylose isomerase domain protein TIM barrel
E4T53_RS02315	COG2222	sugar isomerase
E4T53_RS02320	COG0531	amino acid
E4T53_RS02335	COG2116	formate transmembrane transporter activity
E4T53_RS02340	COG2146	nitrite reductase [NAD(P)H] activity
E4T53_RS02345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T53_RS02355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4T53_RS02365	COG2184	nucleotidyltransferase activity
E4T53_RS02370	COG0512	Glutamine amidotransferase of anthranilate synthase
E4T53_RS02375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T53_RS02380	COG1289	transmembrane transporter activity
E4T53_RS02385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T53_RS02390	COG1765	OsmC-like protein
E4T53_RS02395	COG3954	Phosphoribulokinase
E4T53_RS02405	COG0429	hydrolase of the alpha beta-hydrolase fold
E4T53_RS02410	COG0488	(ABC) transporter
E4T53_RS02425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4T53_RS02430	COG1047	Peptidyl-prolyl cis-trans
E4T53_RS02440	COG0545	Peptidyl-prolyl cis-trans isomerase
E4T53_RS02445	COG2964	Protein conserved in bacteria
E4T53_RS02515	COG0089	rRNA binding
E4T53_RS02605	COG0201	protein transport
E4T53_RS02645	COG0789	Transcriptional regulator
E4T53_RS02650	COG3036	rescue of stalled ribosome
E4T53_RS02660	COG0569	domain protein
E4T53_RS02680	COG0758	DNA mediated transformation
E4T53_RS02690	COG0551	DNA topoisomerase type I activity
E4T53_RS02695	COG0009	L-threonylcarbamoyladenylate synthase
E4T53_RS02710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4T53_RS02750	COG1126	abc transporter atp-binding protein
E4T53_RS02755	COG0765	amino acid transport
E4T53_RS02760	COG4597	amino acid ABC transporter
E4T53_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS02785	COG1309	transcriptional regulator
E4T53_RS02795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4T53_RS02805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T53_RS02815	COG4145	pantothenate transmembrane transporter activity
E4T53_RS02820	COG3924	membrane
E4T53_RS02825	COG0439	Biotin carboxylase
E4T53_RS02830	COG0511	ligase activity, forming carbon-carbon bonds
E4T53_RS02835	COG0604	alcohol dehydrogenase
E4T53_RS02840	COG2200	EAL domain
E4T53_RS02840	COG2199	diguanylate cyclase activity
E4T53_RS02845	COG1077	Cell shape determining protein MreB Mrl
E4T53_RS02850	COG1792	Involved in formation and maintenance of cell shape
E4T53_RS02855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4T53_RS02860	COG0424	maF-like protein
E4T53_RS02865	COG1530	ribonuclease E activity
E4T53_RS02870	COG3164	Protein of unknown function
E4T53_RS02875	COG0312	modulator of DNA gyrase
E4T53_RS02880	COG0583	DNA-binding transcription factor activity
E4T53_RS02900	COG2732	(Barnase) inhibitor
E4T53_RS02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T53_RS02925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T53_RS02930	COG3105	Protein conserved in bacteria
E4T53_RS02935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4T53_RS02950	COG0625	glutathione transferase activity
E4T53_RS02955	COG2969	positive regulation of protein catabolic process
E4T53_RS02960	COG3069	C4-dicarboxylate transmembrane transporter activity
E4T53_RS02990	COG2731	YhcH YjgK YiaL family protein
E4T53_RS02995	COG4804	nuclease activity
E4T53_RS03000	COG0493	'glutamate synthase
E4T53_RS03005	COG0070	glutamate synthase
E4T53_RS03005	COG0067	glutamate synthase
E4T53_RS03005	COG0069	glutamate synthase activity
E4T53_RS03010	COG1242	4 iron, 4 sulfur cluster binding
E4T53_RS03015	COG0784	Response regulator, receiver
E4T53_RS03015	COG2198	Histidine kinase
E4T53_RS03015	COG5002	protein histidine kinase activity
E4T53_RS03020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4T53_RS03030	COG0515	serine threonine protein kinase
E4T53_RS03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS03050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4T53_RS03055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4T53_RS03060	COG1137	ATPase activity
E4T53_RS03065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4T53_RS03070	COG3117	lipopolysaccharide transmembrane transporter activity
E4T53_RS03075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4T53_RS03080	COG0517	IMP dehydrogenase activity
E4T53_RS03080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4T53_RS03085	COG0530	calcium, potassium:sodium antiporter activity
E4T53_RS03090	COG1127	ABC transporter
E4T53_RS03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4T53_RS03100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4T53_RS03105	COG2854	intermembrane phospholipid transfer
E4T53_RS03110	COG3113	response to antibiotic
E4T53_RS03115	COG5007	Belongs to the BolA IbaG family
E4T53_RS03125	COG3423	Transcriptional regulator
E4T53_RS03130	COG0142	geranyltranstransferase activity
E4T53_RS03145	COG0697	spore germination
E4T53_RS03155	COG2027	D-alanyl-D-alanine carboxypeptidase
E4T53_RS03160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T53_RS03165	COG1534	Rna-binding protein
E4T53_RS03175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4T53_RS03180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4T53_RS03190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4T53_RS03200	COG2194	sulfuric ester hydrolase activity
E4T53_RS03220	COG0195	Participates in both transcription termination and antitermination
E4T53_RS03260	COG0513	Belongs to the DEAD box helicase family
E4T53_RS03265	COG0814	amino acid
E4T53_RS03270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T53_RS03275	COG0826	peptidase U32
E4T53_RS03280	COG0826	peptidase U32
E4T53_RS03285	COG3154	lipid carrier protein
E4T53_RS03290	COG3153	acetyltransferase
E4T53_RS03300	COG3787	Belongs to the UPF0306 family
E4T53_RS03305	COG0693	protein deglycase activity
E4T53_RS03310	COG0702	epimerase
E4T53_RS03315	COG0701	Predicted permease
E4T53_RS03320	COG2823	Periplasmic or secreted lipoprotein
E4T53_RS03340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4T53_RS03360	COG3188	usher protein
E4T53_RS03365	COG3121	Chaperone
E4T53_RS03370	COG3539	Fimbrial protein
E4T53_RS03380	COG3716	PTS system mannose fructose sorbose family IID component
E4T53_RS03390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS03400	COG2222	sugar isomerase
E4T53_RS03405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4T53_RS03410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS03415	COG3716	PTS system mannose fructose sorbose family IID component
E4T53_RS03425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS03435	COG1349	DNA-binding transcription factor activity
E4T53_RS03445	COG2002	toxin-antitoxin pair type II binding
E4T53_RS03450	COG2721	sulfolactate sulfo-lyase activity
E4T53_RS03455	COG2271	Major facilitator Superfamily
E4T53_RS03465	COG2084	Dehydrogenase
E4T53_RS03470	COG1929	Belongs to the glycerate kinase type-1 family
E4T53_RS03495	COG0583	DNA-binding transcription factor activity
E4T53_RS03500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T53_RS03510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4T53_RS03515	COG1882	Formate acetyltransferase
E4T53_RS03520	COG0251	oxidation-reduction process
E4T53_RS03525	COG1760	l-serine dehydratase
E4T53_RS03530	COG0814	amino acid
E4T53_RS03545	COG1741	Belongs to the pirin family
E4T53_RS03550	COG0583	DNA-binding transcription factor activity
E4T53_RS03555	COG3152	Membrane
E4T53_RS03560	COG3152	Membrane
E4T53_RS03565	COG0435	Glutathione S-transferase
E4T53_RS03570	COG2259	Doxx family
E4T53_RS03580	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E4T53_RS03585	COG4575	ribosome binding
E4T53_RS03590	COG1422	Protein of unknown function (DUF1090)
E4T53_RS03600	COG0586	Pfam SNARE associated Golgi protein
E4T53_RS03605	COG2186	Transcriptional regulator
E4T53_RS03610	COG2271	Major facilitator Superfamily
E4T53_RS03620	COG2721	sulfolactate sulfo-lyase activity
E4T53_RS03630	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4T53_RS03635	COG0861	Integral membrane protein TerC family
E4T53_RS03640	COG0673	inositol 2-dehydrogenase activity
E4T53_RS03645	COG2949	membrane
E4T53_RS03650	COG1451	nucleotide metabolic process
E4T53_RS03660	COG4680	protein conserved in bacteria
E4T53_RS03665	COG5499	transcription regulator containing HTH domain
E4T53_RS03670	COG1902	pentaerythritol trinitrate reductase activity
E4T53_RS03670	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T53_RS03675	COG3408	Glycogen debranching enzyme
E4T53_RS03675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4T53_RS03685	COG0531	amino acid
E4T53_RS03690	COG2731	YhcH YjgK YiaL family protein
E4T53_RS03695	COG3250	beta-galactosidase activity
E4T53_RS03700	COG1609	Transcriptional regulator
E4T53_RS03705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T53_RS03715	COG0840	transmembrane signaling receptor activity
E4T53_RS03720	COG1695	Transcriptional regulator
E4T53_RS03725	COG2375	cellular response to nickel ion
E4T53_RS03740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4T53_RS03745	COG0358	DNA primase activity
E4T53_RS03750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4T53_RS03760	COG0471	metal ion transport
E4T53_RS03765	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS03770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS03775	COG0583	DNA-binding transcription factor activity
E4T53_RS03785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4T53_RS03800	COG4991	sh3 domain protein
E4T53_RS03805	COG3025	triphosphatase activity
E4T53_RS03830	COG2268	Band 7 protein
E4T53_RS03835	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4T53_RS03865	COG3384	dioxygenase
E4T53_RS03870	COG0754	glutathionylspermidine amidase activity
E4T53_RS03880	COG1538	Outer membrane efflux protein
E4T53_RS03885	COG0494	nUDIX hydrolase
E4T53_RS03890	COG3151	Protein conserved in bacteria
E4T53_RS03895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4T53_RS03900	COG3150	esterase
E4T53_RS03905	COG0187	DNA topoisomerase II activity
E4T53_RS03910	COG4774	siderophore transport
E4T53_RS03915	COG1120	ATPase activity
E4T53_RS03920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T53_RS03925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T53_RS03935	COG1737	Transcriptional regulator
E4T53_RS03940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4T53_RS03945	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T53_RS03950	COG0642	Histidine kinase
E4T53_RS03955	COG0745	RESPONSE REGULATOR receiver
E4T53_RS03960	COG3111	PFAM Bacterial OB fold (BOF) protein
E4T53_RS03965	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4T53_RS03970	COG4166	transmembrane transport
E4T53_RS03975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4T53_RS03980	COG0204	Acyl-transferase
E4T53_RS03985	COG2132	Multicopper oxidase
E4T53_RS03990	COG1032	radical SAM domain protein
E4T53_RS03995	COG4238	major outer membrane lipoprotein
E4T53_RS04005	COG0656	L-ascorbic acid biosynthetic process
E4T53_RS04010	COG1979	alcohol dehydrogenase
E4T53_RS04015	COG2207	Transcriptional regulator
E4T53_RS04020	COG0586	Pfam SNARE associated Golgi protein
E4T53_RS04025	COG0626	cystathionine gamma-synthase activity
E4T53_RS04030	COG0811	peptide transport
E4T53_RS04035	COG0848	biopolymer transport protein
E4T53_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS04050	COG0667	Aldo Keto reductase
E4T53_RS04065	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4T53_RS04070	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS04075	COG5557	Pfam Polysulphide reductase, NrfD
E4T53_RS04080	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4T53_RS04085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4T53_RS04090	COG1773	rubredoxin
E4T53_RS04095	COG0375	protein maturation
E4T53_RS04100	COG0298	carbon dioxide binding
E4T53_RS04105	COG0625	glutathione transferase activity
E4T53_RS04110	COG0754	glutathionylspermidine amidase activity
E4T53_RS04135	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS04140	COG4372	Transposase
E4T53_RS04145	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS04215	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS04230	COG0582	viral genome integration into host DNA
E4T53_RS04240	COG1811	Na channel or pump
E4T53_RS04245	COG1982	Orn Lys Arg decarboxylase major
E4T53_RS04250	COG2211	Major facilitator Superfamily
E4T53_RS04265	COG1194	a g-specific adenine glycosylase
E4T53_RS04275	COG3171	Protein conserved in bacteria
E4T53_RS04285	COG0252	asparaginase activity
E4T53_RS04295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T53_RS04300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4T53_RS04310	COG0762	integral membrane protein
E4T53_RS04315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4T53_RS04320	COG2805	Type II/IV secretion system protein
E4T53_RS04335	COG0189	ligase activity
E4T53_RS04340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4T53_RS04345	COG2356	endonuclease I
E4T53_RS04350	COG3091	SprT-like family
E4T53_RS04355	COG2814	Major facilitator Superfamily
E4T53_RS04375	COG1166	arginine decarboxylase activity
E4T53_RS04390	COG0501	Belongs to the peptidase M48B family
E4T53_RS04395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4T53_RS04400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS04405	COG2213	PTS system mannitol-specific
E4T53_RS04410	COG1063	alcohol dehydrogenase
E4T53_RS04415	COG1494	fructose-1,6-bisphosphatase
E4T53_RS04425	COG1072	(Pantothenic acid kinase))
E4T53_RS04430	COG1122	ATPase activity
E4T53_RS04435	COG1122	ATPase activity
E4T53_RS04460	COG0126	phosphoglycerate kinase activity
E4T53_RS04465	COG0191	fructose-bisphosphate aldolase activity
E4T53_RS04470	COG0668	transmembrane transport
E4T53_RS04480	COG2968	Membrane
E4T53_RS04490	COG0427	acetyl-CoA hydrolase
E4T53_RS04495	COG1024	Enoyl-CoA hydratase
E4T53_RS04500	COG1703	isobutyryl-CoA mutase activity
E4T53_RS04505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4T53_RS04505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4T53_RS04520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T53_RS04535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4T53_RS04555	COG0006	proline dipeptidase activity
E4T53_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T53_RS04565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T53_RS04590	COG2723	6-phospho-beta-galactosidase activity
E4T53_RS04600	COG1272	protein, Hemolysin III
E4T53_RS04610	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4T53_RS04620	COG0716	FMN binding
E4T53_RS04625	COG4974	Belongs to the 'phage' integrase family
E4T53_RS04630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4T53_RS04635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4T53_RS04645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4T53_RS04665	COG2233	PERMEase
E4T53_RS04680	COG2252	PERMEase
E4T53_RS04685	COG0402	S-adenosylhomocysteine deaminase activity
E4T53_RS04690	COG2233	PERMEase
E4T53_RS04695	COG2080	2 iron, 2 sulfur cluster binding
E4T53_RS04695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T53_RS04700	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4T53_RS04705	COG0402	S-adenosylhomocysteine deaminase activity
E4T53_RS04710	COG0493	'glutamate synthase
E4T53_RS04710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS04715	COG2068	MobA-Related Protein
E4T53_RS04720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4T53_RS04725	COG3608	succinylglutamate desuccinylase aspartoacylase
E4T53_RS04725	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T53_RS04730	COG0549	Belongs to the carbamate kinase family
E4T53_RS04740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T53_RS04745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T53_RS04750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4T53_RS04760	COG2080	2 iron, 2 sulfur cluster binding
E4T53_RS04765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4T53_RS04770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T53_RS04775	COG4942	peptidase
E4T53_RS04795	COG2207	Transcriptional regulator
E4T53_RS04900	COG2197	response regulator
E4T53_RS04905	COG0741	lytic transglycosylase activity
E4T53_RS04915	COG0457	Tetratricopeptide repeat
E4T53_RS04915	COG3710	Transcriptional regulator
E4T53_RS04920	COG0457	Tetratricopeptide repeat
E4T53_RS04945	COG3710	Transcriptional regulator
E4T53_RS04950	COG2771	luxR family
E4T53_RS04955	COG0814	amino acid
E4T53_RS04960	COG0183	Belongs to the thiolase family
E4T53_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS04975	COG2814	Major facilitator Superfamily
E4T53_RS04980	COG1794	racemase activity, acting on amino acids and derivatives
E4T53_RS04985	COG0583	DNA-binding transcription factor activity
E4T53_RS04995	COG1609	Transcriptional regulator
E4T53_RS05010	COG0667	Aldo Keto reductase
E4T53_RS05020	COG0861	Integral membrane protein TerC family
E4T53_RS05035	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E4T53_RS05050	COG2165	general secretion pathway protein
E4T53_RS05055	COG4795	General secretion pathway protein
E4T53_RS05065	COG4967	type IV pilus modification protein PilV
E4T53_RS05070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4T53_RS05075	COG1025	Belongs to the peptidase M16 family
E4T53_RS05080	COG1074	ATP-dependent DNA helicase activity
E4T53_RS05085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4T53_RS05090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4T53_RS05090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4T53_RS05095	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T53_RS05115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4T53_RS05120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4T53_RS05125	COG2166	iron-sulfur cluster assembly
E4T53_RS05130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4T53_RS05140	COG0583	DNA-binding transcription factor activity
E4T53_RS05145	COG2363	Small membrane protein
E4T53_RS05155	COG1349	DNA-binding transcription factor activity
E4T53_RS05165	COG1070	Carbohydrate kinase
E4T53_RS05175	COG0738	Major facilitator superfamily
E4T53_RS05180	COG0235	Class ii aldolase
E4T53_RS05185	COG1454	alcohol dehydrogenase
E4T53_RS05195	COG1760	l-serine dehydratase
E4T53_RS05200	COG0814	amino acid
E4T53_RS05205	COG1611	Belongs to the LOG family
E4T53_RS05220	COG3098	single-species biofilm formation
E4T53_RS05225	COG0564	pseudouridine synthase activity
E4T53_RS05230	COG0716	FMN binding
E4T53_RS05235	COG2271	Major facilitator Superfamily
E4T53_RS05245	COG4948	Mandelate Racemase Muconate Lactonizing
E4T53_RS05250	COG3850	Histidine kinase
E4T53_RS05250	COG3437	response regulator, receiver
E4T53_RS05250	COG2205	protein histidine kinase activity
E4T53_RS05250	COG4999	Histidine kinase
E4T53_RS05255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T53_RS05260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T53_RS05265	COG2336	PFAM SpoVT AbrB
E4T53_RS05270	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4T53_RS05275	COG3956	TIGRFAM MazG family protein
E4T53_RS05290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4T53_RS05300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4T53_RS05310	COG0602	queuosine metabolic process
E4T53_RS05315	COG1070	Carbohydrate kinase
E4T53_RS05320	COG2223	nitrite transmembrane transporter activity
E4T53_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS05330	COG0277	FAD linked oxidase domain protein
E4T53_RS05340	COG2086	electron transfer activity
E4T53_RS05350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4T53_RS05355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4T53_RS05360	COG0644	oxidoreductase
E4T53_RS05365	COG0720	synthase
E4T53_RS05370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4T53_RS05390	COG1203	CRISPR-associated helicase, Cas3
E4T53_RS05405	COG1857	crispr-associated protein
E4T53_RS05425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS05430	COG2234	aminopeptidase activity
E4T53_RS05485	COG1388	LysM domain
E4T53_RS05485	COG4942	peptidase
E4T53_RS05490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4T53_RS05495	COG1846	Transcriptional regulator
E4T53_RS05500	COG0163	prenyltransferase activity
E4T53_RS05505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4T53_RS05515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T53_RS05535	COG3604	Transcriptional regulator
E4T53_RS05540	COG0309	Hydrogenase expression formation protein (HypE)
E4T53_RS05545	COG0409	Hydrogenase expression formation protein
E4T53_RS05550	COG0298	carbon dioxide binding
E4T53_RS05555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4T53_RS05560	COG0375	protein maturation
E4T53_RS05570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS05575	COG0651	ATP synthesis coupled electron transport
E4T53_RS05580	COG0650	Formate hydrogenlyase subunit 4
E4T53_RS05585	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4T53_RS05585	COG3261	NADH dehydrogenase
E4T53_RS05590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T53_RS05595	COG3260	NADH ubiquinone oxidoreductase 20
E4T53_RS05605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4T53_RS05610	COG2723	6-phospho-beta-galactosidase activity
E4T53_RS05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS05615	COG1263	PTS System
E4T53_RS05620	COG1609	Transcriptional regulator
E4T53_RS05625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS05630	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4T53_RS05650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4T53_RS05650	COG0517	IMP dehydrogenase activity
E4T53_RS05655	COG1349	DNA-binding transcription factor activity
E4T53_RS05660	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS05685	COG2951	lytic endotransglycosylase activity
E4T53_RS05690	COG1546	Belongs to the CinA family
E4T53_RS05705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4T53_RS05710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4T53_RS05740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T53_RS05745	COG1238	metal cluster binding
E4T53_RS05760	COG2814	Major facilitator Superfamily
E4T53_RS05765	COG1566	PFAM secretion protein HlyD family protein
E4T53_RS05770	COG1846	Transcriptional regulator
E4T53_RS05780	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4T53_RS05785	COG2814	Major facilitator Superfamily
E4T53_RS05790	COG2113	Glycine betaine
E4T53_RS05795	COG4176	ABC-type proline glycine betaine transport system permease component
E4T53_RS05800	COG4175	Glycine betaine
E4T53_RS05805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T53_RS05810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T53_RS05820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4T53_RS05825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T53_RS05835	COG4575	ribosome binding
E4T53_RS05850	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4T53_RS05855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T53_RS05860	COG0640	Transcriptional regulator
E4T53_RS05865	COG0401	homolog of Blt101
E4T53_RS05870	COG1652	LysM domain
E4T53_RS05875	COG1802	Transcriptional regulator
E4T53_RS05880	COG1113	amino acid transport
E4T53_RS05885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T53_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS05895	COG0579	oxidoreductase
E4T53_RS05985	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS06105	COG2867	negative regulation of translational initiation
E4T53_RS06115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T53_RS06120	COG0497	DNA recombination
E4T53_RS06135	COG4536	flavin adenine dinucleotide binding
E4T53_RS06140	COG4137	Cytochrome C assembly protein
E4T53_RS06145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4T53_RS06170	COG2885	chlorophyll binding
E4T53_RS06175	COG2199	diguanylate cyclase activity
E4T53_RS06190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4T53_RS06195	COG0287	Prephenate dehydrogenase
E4T53_RS06195	COG1605	Chorismate mutase
E4T53_RS06200	COG1605	Chorismate mutase
E4T53_RS06200	COG0077	Prephenate dehydratase
E4T53_RS06210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4T53_RS06215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T53_RS06220	COG0564	pseudouridine synthase activity
E4T53_RS06230	COG0542	response to heat
E4T53_RS06255	COG0477	Major facilitator Superfamily
E4T53_RS06260	COG5544	Lipoprotein
E4T53_RS06265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T53_RS06270	COG1042	CoA-binding domain protein
E4T53_RS06270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T53_RS06270	COG0045	succinate-CoA ligase (ADP-forming) activity
E4T53_RS06280	COG3118	belongs to the thioredoxin family
E4T53_RS06285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T53_RS06300	COG1280	lysine exporter protein (LysE YggA)
E4T53_RS06305	COG0583	DNA-binding transcription factor activity
E4T53_RS06310	COG0513	Belongs to the DEAD box helicase family
E4T53_RS06315	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4T53_RS06320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4T53_RS06330	COG1595	DNA-templated transcription, initiation
E4T53_RS06335	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4T53_RS06340	COG3026	antisigma factor binding
E4T53_RS06345	COG3086	response to oxidative stress
E4T53_RS06355	COG0681	Belongs to the peptidase S26 family
E4T53_RS06375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4T53_RS06390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS06395	COG1737	Transcriptional regulator
E4T53_RS06400	COG0560	Phosphoserine phosphatase
E4T53_RS06405	COG0590	tRNA wobble adenosine to inosine editing
E4T53_RS06410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4T53_RS06415	COG0047	phosphoribosylformylglycinamidine synthase activity
E4T53_RS06415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4T53_RS06420	COG2205	protein histidine kinase activity
E4T53_RS06425	COG3170	Tfp pilus assembly protein FimV
E4T53_RS06430	COG2204	response regulator
E4T53_RS06435	COG0347	Belongs to the P(II) protein family
E4T53_RS06440	COG1017	nitric oxide dioxygenase activity
E4T53_RS06440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T53_RS06450	COG1940	carbohydrate kinase activity
E4T53_RS06455	COG0457	Tetratricopeptide repeat
E4T53_RS06460	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS06465	COG1129	ABC transporter
E4T53_RS06470	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS06475	COG1063	alcohol dehydrogenase
E4T53_RS06480	COG1063	alcohol dehydrogenase
E4T53_RS06485	COG2017	converts alpha-aldose to the beta-anomer
E4T53_RS06490	COG2259	Doxx family
E4T53_RS06515	COG4638	Rieske (2fe-2S)
E4T53_RS06520	COG0583	DNA-binding transcription factor activity
E4T53_RS06525	COG2814	Major facilitator Superfamily
E4T53_RS06530	COG3711	transcriptional antiterminator
E4T53_RS06535	COG1073	alpha beta
E4T53_RS06540	COG0483	inositol monophosphate 1-phosphatase activity
E4T53_RS06560	COG0822	iron-sulfur transferase activity
E4T53_RS06580	COG0633	Ferredoxin
E4T53_RS06585	COG2975	iron-sulfur cluster assembly
E4T53_RS06600	COG2897	thiosulfate sulfurtransferase activity
E4T53_RS06605	COG2373	Large extracellular alpha-helical protein
E4T53_RS06610	COG4953	penicillin-binding protein 1C
E4T53_RS06615	COG0243	molybdopterin cofactor binding
E4T53_RS06620	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS06625	COG3302	dmso reductase anchor subunit
E4T53_RS06660	COG2976	Protein conserved in bacteria
E4T53_RS06675	COG1645	bacterial-type flagellum-dependent swarming motility
E4T53_RS06685	COG0517	IMP dehydrogenase activity
E4T53_RS06685	COG0516	GMP reductase activity
E4T53_RS06700	COG3133	Outer membrane lipoprotein
E4T53_RS06715	COG2200	EAL domain
E4T53_RS06720	COG0248	Ppx GppA phosphatase
E4T53_RS06725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4T53_RS06730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4T53_RS06745	COG2233	PERMEase
E4T53_RS06755	COG1393	Belongs to the ArsC family
E4T53_RS06760	COG4783	chaperone-mediated protein folding
E4T53_RS06765	COG0628	permease
E4T53_RS06770	COG2116	formate transmembrane transporter activity
E4T53_RS06775	COG3604	Transcriptional regulator
E4T53_RS06785	COG3260	NADH ubiquinone oxidoreductase 20
E4T53_RS06790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T53_RS06795	COG3261	NADH dehydrogenase
E4T53_RS06795	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4T53_RS06800	COG0651	ATP synthesis coupled electron transport
E4T53_RS06805	COG4237	Hydrogenase 4 membrane
E4T53_RS06810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4T53_RS06815	COG0650	Formate hydrogenlyase subunit 4
E4T53_RS06820	COG0651	ATP synthesis coupled electron transport
E4T53_RS06825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS06830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4T53_RS06835	COG2716	regulation of RNA biosynthetic process
E4T53_RS06845	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4T53_RS06855	COG2321	neutral zinc metallopeptidase
E4T53_RS06865	COG0400	carboxylic ester hydrolase activity
E4T53_RS06880	COG1393	Belongs to the ArsC family
E4T53_RS06890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T53_RS06895	COG3850	Histidine kinase
E4T53_RS06900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS06900	COG0493	'glutamate synthase
E4T53_RS06910	COG5342	invasion associated locus B
E4T53_RS06915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4T53_RS06920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T53_RS06925	COG0281	malic enzyme
E4T53_RS06925	COG0280	phosphate acetyltransferase
E4T53_RS06930	COG4810	utilization protein
E4T53_RS06935	COG4917	ethanolamine utilization protein
E4T53_RS06940	COG4766	ethanolamine catabolic process
E4T53_RS06945	COG4812	Cobalamin adenosyltransferase
E4T53_RS06950	COG0280	phosphate acetyltransferase
E4T53_RS06955	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4T53_RS06960	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E4T53_RS06965	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS06970	COG4820	ethanolamine utilization protein (EutJ)
E4T53_RS06975	COG1454	alcohol dehydrogenase
E4T53_RS06980	COG3192	ethanolamine utilization protein
E4T53_RS06985	COG4819	ethanolamine utilization protein
E4T53_RS06990	COG4303	Ethanolamine ammonia lyase large subunit
E4T53_RS07000	COG4816	utilization protein
E4T53_RS07005	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4T53_RS07010	COG2207	Transcriptional regulator
E4T53_RS07020	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T53_RS07040	COG2837	iron assimilation
E4T53_RS07045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T53_RS07050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS07050	COG1263	PTS System
E4T53_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS07070	COG4150	thiosulfate binding
E4T53_RS07075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4T53_RS07080	COG4208	sulfate ABC transporter
E4T53_RS07085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4T53_RS07090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T53_RS07105	COG2190	(PTS) system
E4T53_RS07110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T53_RS07115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS07120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T53_RS07140	COG3530	Putative quorum-sensing-regulated virulence factor
E4T53_RS07145	COG0385	Bile acid
E4T53_RS07150	COG0583	DNA-binding transcription factor activity
E4T53_RS07195	COG3415	Transposase
E4T53_RS07200	COG3415	Transposase
E4T53_RS07215	COG2199	diguanylate cyclase activity
E4T53_RS07215	COG2200	EAL domain
E4T53_RS07220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T53_RS07245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS07250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS07255	COG0006	proline dipeptidase activity
E4T53_RS07260	COG1363	Peptidase, m42
E4T53_RS07265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS07265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T53_RS07265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS07270	COG2207	Transcriptional regulator
E4T53_RS07275	COG3279	Response regulator of the LytR AlgR family
E4T53_RS07315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T53_RS07340	COG3299	homolog of phage Mu protein gp47
E4T53_RS07350	COG4384	Bacteriophage Mu Gp45 protein
E4T53_RS07370	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
E4T53_RS07380	COG4386	tail sheath protein
E4T53_RS07405	COG4397	Mu-like prophage major head subunit gpT
E4T53_RS07410	COG4388	Caudovirus prohead serine protease
E4T53_RS07415	COG5005	Phage virion morphogenesis
E4T53_RS07420	COG2369	cell adhesion
E4T53_RS07425	COG4383	Mu-like prophage protein gp29
E4T53_RS07430	COG4373	Mu-like prophage FluMu protein gp28
E4T53_RS07470	COG5566	PFAM Mor transcription activator
E4T53_RS07525	COG4396	Host-nuclease inhibitor protein Gam
E4T53_RS07555	COG2842	Transposition protein
E4T53_RS07565	COG3423	Transcriptional regulator
E4T53_RS07580	COG0436	Aminotransferase
E4T53_RS07590	COG1560	Kdo2-lipid A biosynthetic process
E4T53_RS07615	COG0028	Belongs to the TPP enzyme family
E4T53_RS07620	COG0679	Auxin Efflux Carrier
E4T53_RS07625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4T53_RS07630	COG2205	protein histidine kinase activity
E4T53_RS07630	COG2198	Histidine kinase
E4T53_RS07630	COG0784	Response regulator, receiver
E4T53_RS07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS07635	COG2197	response regulator
E4T53_RS07640	COG1566	PFAM secretion protein HlyD family protein
E4T53_RS07645	COG0477	Major facilitator Superfamily
E4T53_RS07725	COG0582	viral genome integration into host DNA
E4T53_RS07735	COG2116	formate transmembrane transporter activity
E4T53_RS07740	COG2853	Lipoprotein
E4T53_RS07750	COG2067	long-chain fatty acid transport protein
E4T53_RS07755	COG3691	Protein conserved in bacteria
E4T53_RS07770	COG2062	phosphohistidine phosphatase, SixA
E4T53_RS07775	COG3539	Fimbrial protein
E4T53_RS07780	COG3188	usher protein
E4T53_RS07785	COG3121	Chaperone
E4T53_RS07790	COG3539	Fimbrial protein
E4T53_RS07795	COG3539	Fimbrial protein
E4T53_RS07800	COG3539	Fimbrial protein
E4T53_RS07830	COG0730	response to heat
E4T53_RS07835	COG3101	peptidyl-lysine hydroxylation
E4T53_RS07845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T53_RS07845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4T53_RS07850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T53_RS07855	COG2814	Major facilitator Superfamily
E4T53_RS07870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4T53_RS07880	COG0586	Pfam SNARE associated Golgi protein
E4T53_RS07890	COG0285	dihydrofolate synthase activity
E4T53_RS07895	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4T53_RS07900	COG1286	toxin biosynthetic process
E4T53_RS07905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4T53_RS07910	COG0163	prenyltransferase activity
E4T53_RS07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS07925	COG4215	(ABC) transporter
E4T53_RS07930	COG4160	amino acid transport
E4T53_RS07935	COG4598	ABC transporter
E4T53_RS07940	COG5464	transposase or invertase
E4T53_RS07945	COG1090	epimerase
E4T53_RS07950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4T53_RS07955	COG0625	glutathione transferase activity
E4T53_RS07960	COG0625	glutathione transferase activity
E4T53_RS07965	COG0622	Phosphoesterase
E4T53_RS07970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4T53_RS07975	COG1288	antiporter activity
E4T53_RS07980	COG0280	phosphate acetyltransferase
E4T53_RS07980	COG0857	belongs to the CobB CobQ family
E4T53_RS07985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4T53_RS08000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T53_RS08005	COG0490	domain, Protein
E4T53_RS08005	COG0471	metal ion transport
E4T53_RS08015	COG0436	Aminotransferase
E4T53_RS08020	COG0583	DNA-binding transcription factor activity
E4T53_RS08040	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4T53_RS08045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4T53_RS08050	COG1034	ATP synthesis coupled electron transport
E4T53_RS08065	COG0839	Belongs to the complex I subunit 6 family
E4T53_RS08075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4T53_RS08080	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T53_RS08105	COG5160	protein modification by small protein removal
E4T53_RS08110	COG1234	tRNA 3'-trailer cleavage
E4T53_RS08115	COG2153	protein acetylation
E4T53_RS08120	COG4575	ribosome binding
E4T53_RS08125	COG1169	isochorismate synthase
E4T53_RS08140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4T53_RS08150	COG0318	PFAM AMP-dependent synthetase and ligase
E4T53_RS08195	COG0406	alpha-ribazole phosphatase activity
E4T53_RS08215	COG1414	Transcriptional regulator
E4T53_RS08220	COG4948	Mandelate Racemase Muconate Lactonizing
E4T53_RS08225	COG2271	Major facilitator Superfamily
E4T53_RS08240	COG3836	Belongs to the HpcH HpaI aldolase family
E4T53_RS08245	COG5464	transposase or invertase
E4T53_RS08250	COG0247	lactate metabolic process
E4T53_RS08260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4T53_RS08265	COG2271	Major facilitator Superfamily
E4T53_RS08270	COG0584	glycerophosphoryl diester phosphodiesterase
E4T53_RS08280	COG0583	DNA-binding transcription factor activity
E4T53_RS08285	COG2814	Major facilitator Superfamily
E4T53_RS08290	COG3642	lipopolysaccharide core region biosynthetic process
E4T53_RS08295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T53_RS08300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T53_RS08305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T53_RS08310	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS08320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4T53_RS08325	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E4T53_RS08330	COG3234	Protein of unknown function (DUF1175)
E4T53_RS08335	COG2373	Large extracellular alpha-helical protein
E4T53_RS08340	COG5445	Predicted secreted protein (DUF2300)
E4T53_RS08345	COG5445	Predicted secreted protein (DUF2300)
E4T53_RS08350	COG4676	Protein conserved in bacteria
E4T53_RS08355	COG2205	protein histidine kinase activity
E4T53_RS08355	COG0784	Response regulator, receiver
E4T53_RS08360	COG2197	response regulator
E4T53_RS08365	COG2198	Histidine kinase
E4T53_RS08365	COG0642	Histidine kinase
E4T53_RS08370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4T53_RS08375	COG1477	protein flavinylation
E4T53_RS08380	COG2169	Transcriptional regulator
E4T53_RS08380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T53_RS08385	COG3145	DNA-N1-methyladenine dioxygenase activity
E4T53_RS08390	COG4615	Cyclic peptide transporter
E4T53_RS08405	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS08405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T53_RS08410	COG3062	negative regulation of establishment of protein localization
E4T53_RS08420	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS08425	COG0348	domain, Protein
E4T53_RS08430	COG3043	anaerobic respiration
E4T53_RS08435	COG3005	denitrification pathway
E4T53_RS08440	COG4133	protoheme IX ABC transporter activity
E4T53_RS08445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4T53_RS08450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4T53_RS08455	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4T53_RS08465	COG1138	Cytochrome C-type biogenesis protein
E4T53_RS08470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T53_RS08475	COG3088	subunit of a heme lyase
E4T53_RS08475	COG4235	cytochrome complex assembly
E4T53_RS08480	COG2197	response regulator
E4T53_RS08485	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS08495	COG3083	sulfuric ester hydrolase activity
E4T53_RS08515	COG1061	Type III restriction enzyme res subunit
E4T53_RS08520	COG1187	pseudouridine synthase activity
E4T53_RS08525	COG2814	Major facilitator Superfamily
E4T53_RS08535	COG4172	Belongs to the ABC transporter superfamily
E4T53_RS08540	COG4239	(ABC) transporter, permease
E4T53_RS08545	COG4174	ABC transporter (Permease)
E4T53_RS08550	COG4166	transmembrane transport
E4T53_RS08555	COG2200	EAL domain
E4T53_RS08560	COG0791	NLP P60 protein
E4T53_RS08565	COG0671	phosphoesterase, PA-phosphatase related
E4T53_RS08570	COG0523	cobalamin synthesis protein
E4T53_RS08575	COG0246	Mannitol dehydrogenase
E4T53_RS08590	COG2814	Major facilitator Superfamily
E4T53_RS08595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS08595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS08600	COG1105	Belongs to the carbohydrate kinase PfkB family
E4T53_RS08605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4T53_RS08605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS08605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS08610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS08615	COG2313	pseudouridylate synthase activity
E4T53_RS08620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T53_RS08625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T53_RS08635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4T53_RS08640	COG1522	sequence-specific DNA binding
E4T53_RS08640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS08650	COG2855	membrane
E4T53_RS08655	COG0583	DNA-binding transcription factor activity
E4T53_RS08660	COG0833	amino acid
E4T53_RS08665	COG4771	TonB-dependent receptor
E4T53_RS08670	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4T53_RS08680	COG2311	Membrane
E4T53_RS08685	COG1609	Transcriptional regulator
E4T53_RS08690	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS08695	COG1129	ABC transporter
E4T53_RS08700	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS08705	COG0167	dihydroorotate dehydrogenase activity
E4T53_RS08705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4T53_RS08710	COG0493	'glutamate synthase
E4T53_RS08720	COG2949	membrane
E4T53_RS08730	COG1346	cytolysis
E4T53_RS08745	COG2271	Major facilitator Superfamily
E4T53_RS08760	COG0625	glutathione transferase activity
E4T53_RS08765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T53_RS08770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T53_RS08780	COG1538	Outer membrane efflux protein
E4T53_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS08790	COG0586	Pfam SNARE associated Golgi protein
E4T53_RS08800	COG1686	Belongs to the peptidase S11 family
E4T53_RS08805	COG0277	FAD linked oxidase domain protein
E4T53_RS08810	COG1472	Belongs to the glycosyl hydrolase 3 family
E4T53_RS08815	COG1732	Glycine betaine
E4T53_RS08820	COG1174	glycine betaine transport
E4T53_RS08825	COG1125	glycine betaine transport
E4T53_RS08830	COG1174	glycine betaine transport
E4T53_RS08840	COG0789	Transcriptional regulator
E4T53_RS08845	COG0582	viral genome integration into host DNA
E4T53_RS08955	COG4680	protein conserved in bacteria
E4T53_RS09060	COG4372	Transposase
E4T53_RS09065	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS09090	COG3772	lysozyme
E4T53_RS09200	COG1185	polyribonucleotide nucleotidyltransferase activity
E4T53_RS09235	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS09260	COG3275	phosphorelay sensor kinase activity
E4T53_RS09265	COG3279	Response regulator of the LytR AlgR family
E4T53_RS09270	COG4807	Protein conserved in bacteria
E4T53_RS09275	COG4808	Protein conserved in bacteria
E4T53_RS09280	COG4715	Zinc finger, swim domain protein
E4T53_RS09285	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4T53_RS09290	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4T53_RS09295	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4T53_RS09300	COG0714	Associated with various cellular activities
E4T53_RS09310	COG3831	ATPase activity
E4T53_RS09340	COG0489	protein tyrosine kinase activity
E4T53_RS09350	COG3539	Fimbrial protein
E4T53_RS09355	COG3121	Chaperone
E4T53_RS09360	COG3188	usher protein
E4T53_RS09365	COG3539	Fimbrial protein
E4T53_RS09370	COG5455	response to cobalt ion
E4T53_RS09375	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4T53_RS09405	COG0351	phosphomethylpyrimidine kinase
E4T53_RS09410	COG3757	hydrolase, family 25
E4T53_RS09415	COG2188	Transcriptional regulator
E4T53_RS09420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS09425	COG1397	ADP-ribosylglycohydrolase
E4T53_RS09430	COG2211	Major facilitator Superfamily
E4T53_RS09435	COG1830	Aldolase
E4T53_RS09450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS09455	COG3414	Phosphotransferase system galactitol-specific IIB component
E4T53_RS09460	COG3775	system Galactitol-specific IIC component
E4T53_RS09465	COG1063	alcohol dehydrogenase
E4T53_RS09485	COG4974	Belongs to the 'phage' integrase family
E4T53_RS09550	COG4695	Portal protein
E4T53_RS09645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4T53_RS09660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T53_RS09710	COG3422	double-strand break repair
E4T53_RS09715	COG0745	RESPONSE REGULATOR receiver
E4T53_RS09720	COG2205	protein histidine kinase activity
E4T53_RS09735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T53_RS09760	COG4245	von Willebrand factor, type A
E4T53_RS09765	COG0631	protein serine/threonine phosphatase activity
E4T53_RS09770	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E4T53_RS09775	COG0443	Heat shock 70 kDa protein
E4T53_RS09780	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4T53_RS09790	COG0572	uridine kinase
E4T53_RS09800	COG2982	Protein involved in outer membrane biogenesis
E4T53_RS09815	COG1253	flavin adenine dinucleotide binding
E4T53_RS09825	COG1596	polysaccharide export
E4T53_RS09830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T53_RS09835	COG0489	protein tyrosine kinase activity
E4T53_RS09835	COG3206	protein involved in exopolysaccharide biosynthesis
E4T53_RS09840	COG0463	Glycosyl transferase, family 2
E4T53_RS09845	COG1045	serine acetyltransferase
E4T53_RS09850	COG0438	transferase activity, transferring glycosyl groups
E4T53_RS09860	COG1216	Glycosyl transferase, family 2
E4T53_RS09865	COG0110	maltose O-acetyltransferase activity
E4T53_RS09870	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4T53_RS09875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T53_RS09880	COG1051	belongs to the nudix hydrolase family
E4T53_RS09885	COG0297	glycogen (starch) synthase activity
E4T53_RS09890	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4T53_RS09890	COG0662	Cupin 2, conserved barrel domain protein
E4T53_RS09895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4T53_RS09900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4T53_RS09905	COG2244	polysaccharide biosynthetic process
E4T53_RS09910	COG2327	Polysaccharide pyruvyl transferase
E4T53_RS09915	COG0438	transferase activity, transferring glycosyl groups
E4T53_RS09925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T53_RS09930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4T53_RS09955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T53_RS09965	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4T53_RS09970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T53_RS09975	COG1051	belongs to the nudix hydrolase family
E4T53_RS09980	COG0662	Cupin 2, conserved barrel domain protein
E4T53_RS09980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4T53_RS09985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4T53_RS09995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4T53_RS10000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4T53_RS10025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4T53_RS10030	COG0131	Imidazoleglycerol-phosphate dehydratase
E4T53_RS10030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4T53_RS10040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4T53_RS10055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T53_RS10060	COG0583	DNA-binding transcription factor activity
E4T53_RS10070	COG0531	amino acid
E4T53_RS10075	COG2391	methyltransferase activity
E4T53_RS10080	COG0425	Belongs to the sulfur carrier protein TusA family
E4T53_RS10085	COG2925	Exonuclease
E4T53_RS10090	COG0582	viral genome integration into host DNA
E4T53_RS10330	COG3772	lysozyme
E4T53_RS10435	COG1185	polyribonucleotide nucleotidyltransferase activity
E4T53_RS10475	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS10485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T53_RS10495	COG1686	Belongs to the peptidase S11 family
E4T53_RS10505	COG1289	transmembrane transporter activity
E4T53_RS10520	COG4917	ethanolamine utilization protein
E4T53_RS10555	COG2003	Belongs to the UPF0758 family
E4T53_RS10595	COG4771	TonB-dependent receptor
E4T53_RS10600	COG4372	Transposase
E4T53_RS10605	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS10615	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E4T53_RS10630	COG1376	ErfK ybiS ycfS ynhG family protein
E4T53_RS10640	COG0583	DNA-binding transcription factor activity
E4T53_RS10645	COG0583	DNA-binding transcription factor activity
E4T53_RS10655	COG0534	Mate efflux family protein
E4T53_RS10665	COG0217	transcriptional regulatory protein
E4T53_RS10670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4T53_RS10675	COG0477	Major facilitator Superfamily
E4T53_RS10685	COG1388	LysM domain
E4T53_RS10685	COG4932	domain protein
E4T53_RS10685	COG2373	Large extracellular alpha-helical protein
E4T53_RS10715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS10760	COG1846	Transcriptional regulator
E4T53_RS10805	COG1403	HNH endonuclease
E4T53_RS10810	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4T53_RS10860	COG3772	lysozyme
E4T53_RS10890	COG4220	transposase activity
E4T53_RS10985	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS11005	COG3038	cytochrome b561
E4T53_RS11010	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4T53_RS11025	COG2351	hydroxyisourate hydrolase activity
E4T53_RS11030	COG0745	RESPONSE REGULATOR receiver
E4T53_RS11035	COG2205	protein histidine kinase activity
E4T53_RS11055	COG1418	mRNA catabolic process
E4T53_RS11060	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4T53_RS11065	COG3727	T/G mismatch-specific endonuclease activity
E4T53_RS11070	COG0697	spore germination
E4T53_RS11075	COG2354	Protein conserved in bacteria
E4T53_RS11080	COG5475	Uncharacterized small protein (DUF2158)
E4T53_RS11085	COG3706	GGDEF domain
E4T53_RS11105	COG2197	response regulator
E4T53_RS11110	COG1684	flagellar biosynthetic protein fliR
E4T53_RS11115	COG1987	bacterial-type flagellum assembly
E4T53_RS11120	COG1338	Plays a role in the flagellum-specific transport system
E4T53_RS11125	COG3190	flagellar
E4T53_RS11130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T53_RS11135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T53_RS11140	COG1580	Controls the rotational direction of flagella during chemotaxis
E4T53_RS11145	COG3144	bacterial-type flagellum assembly
E4T53_RS11150	COG2882	bacterial-type flagellum organization
E4T53_RS11155	COG1157	protein secretion by the type III secretion system
E4T53_RS11160	COG1317	bacterial-type flagellum organization
E4T53_RS11165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4T53_RS11170	COG1766	The M ring may be actively involved in energy transduction
E4T53_RS11185	COG0454	-acetyltransferase
E4T53_RS11195	COG0454	-acetyltransferase
E4T53_RS11200	COG2135	peptidase activity
E4T53_RS11205	COG0425	Belongs to the sulfur carrier protein TusA family
E4T53_RS11210	COG2391	methyltransferase activity
E4T53_RS11220	COG0366	Alpha amylase catalytic
E4T53_RS11230	COG1516	flagellar protein fliS
E4T53_RS11235	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4T53_RS11245	COG1191	sigma factor activity
E4T53_RS11275	COG2197	response regulator
E4T53_RS11290	COG2197	response regulator
E4T53_RS11375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4T53_RS11475	COG4974	Belongs to the 'phage' integrase family
E4T53_RS11480	COG3318	Belongs to the UPF0149 family
E4T53_RS11480	COG3012	SEC-C Motif Domain Protein
E4T53_RS11485	COG0814	amino acid
E4T53_RS11495	COG1528	Iron-storage protein
E4T53_RS11515	COG1528	Iron-storage protein
E4T53_RS11520	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS11525	COG1129	ABC transporter
E4T53_RS11530	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS11535	COG1877	trehalose-phosphatase activity
E4T53_RS11545	COG0589	response to stress
E4T53_RS11560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4T53_RS11565	COG1360	Flagellar Motor Protein
E4T53_RS11570	COG2198	Histidine kinase
E4T53_RS11570	COG0643	Histidine kinase
E4T53_RS11575	COG0835	chemotaxis
E4T53_RS11580	COG0840	transmembrane signaling receptor activity
E4T53_RS11585	COG0840	transmembrane signaling receptor activity
E4T53_RS11590	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4T53_RS11595	COG2201	protein-glutamate methylesterase activity
E4T53_RS11600	COG0745	RESPONSE REGULATOR receiver
E4T53_RS11610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4T53_RS11615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4T53_RS11625	COG3755	Protein conserved in bacteria
E4T53_RS11635	COG3102	Protein conserved in bacteria
E4T53_RS11645	COG3005	denitrification pathway
E4T53_RS11650	COG0243	molybdopterin cofactor binding
E4T53_RS11665	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4T53_RS11670	COG1801	Protein of unknown function DUF72
E4T53_RS11675	COG1335	isochorismatase
E4T53_RS11685	COG0494	nUDIX hydrolase
E4T53_RS11690	COG0217	transcriptional regulatory protein
E4T53_RS11720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T53_RS11730	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4T53_RS11735	COG0739	heme binding
E4T53_RS11740	COG1560	Kdo2-lipid A biosynthetic process
E4T53_RS11745	COG0469	pyruvate kinase activity
E4T53_RS11750	COG1737	Transcriptional regulator
E4T53_RS11755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4T53_RS11760	COG0129	dihydroxy-acid dehydratase activity
E4T53_RS11765	COG0800	Aldolase
E4T53_RS11770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4T53_RS11775	COG3141	response to X-ray
E4T53_RS11785	COG2979	Protein of unknown function (DUF533)
E4T53_RS11790	COG1770	oligopeptidase
E4T53_RS11795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS11800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T53_RS11810	COG2372	response to copper ion
E4T53_RS11815	COG1276	copper resistance
E4T53_RS11825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T53_RS11845	COG3008	intermembrane lipid transfer
E4T53_RS11850	COG2995	paraquat-inducible protein a
E4T53_RS11855	COG1956	GAF domain-containing protein
E4T53_RS11865	COG0793	Belongs to the peptidase S41A family
E4T53_RS11875	COG2814	Major facilitator Superfamily
E4T53_RS11880	COG1414	Transcriptional regulator
E4T53_RS11910	COG2226	methyltransferase
E4T53_RS11925	COG3716	PTS system mannose fructose sorbose family IID component
E4T53_RS11930	COG3715	PTS system
E4T53_RS11935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS11935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS11940	COG1253	flavin adenine dinucleotide binding
E4T53_RS11945	COG2200	EAL domain
E4T53_RS11950	COG1760	l-serine dehydratase
E4T53_RS11960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4T53_RS11975	COG0251	oxidation-reduction process
E4T53_RS11980	COG1199	ATP-dependent helicase activity
E4T53_RS11985	COG1214	PFAM Peptidase M22, glycoprotease
E4T53_RS11990	COG3065	identical protein binding
E4T53_RS11995	COG0318	PFAM AMP-dependent synthetase and ligase
E4T53_RS12000	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4T53_RS12005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T53_RS12010	COG4638	Rieske (2fe-2S)
E4T53_RS12015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T53_RS12020	COG0473	3-isopropylmalate dehydrogenase activity
E4T53_RS12025	COG0583	DNA-binding transcription factor activity
E4T53_RS12030	COG1280	lysine exporter protein (LysE YggA)
E4T53_RS12035	COG3615	Tellurite resistance protein tehB
E4T53_RS12045	COG2261	transglycosylase associated protein
E4T53_RS12060	COG2203	Gaf domain
E4T53_RS12060	COG2199	diguanylate cyclase activity
E4T53_RS12065	COG3042	response to heat
E4T53_RS12070	COG3189	MarR family transcriptional regulator
E4T53_RS12075	COG2807	transmembrane transport
E4T53_RS12080	COG2207	Transcriptional regulator
E4T53_RS12095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4T53_RS12100	COG2199	diguanylate cyclase activity
E4T53_RS12105	COG2199	diguanylate cyclase activity
E4T53_RS12115	COG2766	serine protein kinase
E4T53_RS12120	COG3713	MltA-interacting MipA family protein
E4T53_RS12125	COG0656	L-ascorbic acid biosynthetic process
E4T53_RS12130	COG0676	glucose-6-phosphate 1-epimerase activity
E4T53_RS12135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4T53_RS12145	COG3139	Protein of unknown function (DUF1315)
E4T53_RS12150	COG1063	alcohol dehydrogenase
E4T53_RS12155	COG2271	Major facilitator Superfamily
E4T53_RS12160	COG1063	alcohol dehydrogenase
E4T53_RS12165	COG0191	fructose-bisphosphate aldolase activity
E4T53_RS12170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS12175	COG0667	Aldo Keto reductase
E4T53_RS12180	COG1349	DNA-binding transcription factor activity
E4T53_RS12195	COG1335	isochorismatase
E4T53_RS12200	COG0252	asparaginase activity
E4T53_RS12210	COG0616	signal peptide processing
E4T53_RS12215	COG0778	Nitroreductase
E4T53_RS12220	COG0709	Synthesizes selenophosphate from selenide and ATP
E4T53_RS12225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4T53_RS12235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4T53_RS12245	COG0494	nUDIX hydrolase
E4T53_RS12250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4T53_RS12255	COG2897	thiosulfate sulfurtransferase activity
E4T53_RS12260	COG4136	ATPase activity
E4T53_RS12265	COG4135	transport system, permease component
E4T53_RS12270	COG4134	Bacterial extracellular solute-binding protein
E4T53_RS12275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T53_RS12280	COG0398	Pfam SNARE associated Golgi protein
E4T53_RS12290	COG0398	Pfam SNARE associated Golgi protein
E4T53_RS12295	COG0708	Exodeoxyribonuclease III
E4T53_RS12325	COG3678	ATP-independent chaperone mediated protein folding
E4T53_RS12335	COG0322	excinuclease ABC activity
E4T53_RS12345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T53_RS12350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T53_RS12355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4T53_RS12360	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4T53_RS12365	COG1917	Cupin 2, conserved barrel domain protein
E4T53_RS12365	COG2169	Transcriptional regulator
E4T53_RS12370	COG1486	melibiose metabolic process
E4T53_RS12380	COG0753	catalase activity
E4T53_RS12400	COG1988	membrane-bound metal-dependent
E4T53_RS12405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T53_RS12415	COG3001	Fructosamine kinase
E4T53_RS12425	COG1105	Belongs to the carbohydrate kinase PfkB family
E4T53_RS12430	COG3137	Salt-induced outer membrane protein
E4T53_RS12475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T53_RS12475	COG0072	phenylalanine-tRNA ligase activity
E4T53_RS12490	COG0386	Belongs to the glutathione peroxidase family
E4T53_RS12500	COG0791	NLP P60 protein
E4T53_RS12505	COG2200	EAL domain
E4T53_RS12515	COG4256	Hemin uptake protein
E4T53_RS12520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4T53_RS12530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T53_RS12530	COG0574	Belongs to the PEP-utilizing enzyme family
E4T53_RS12540	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4T53_RS12545	COG0644	oxidoreductase
E4T53_RS12550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4T53_RS12555	COG2086	electron transfer activity
E4T53_RS12560	COG2207	Transcriptional regulator
E4T53_RS12560	COG1917	Cupin 2, conserved barrel domain protein
E4T53_RS12565	COG1960	acyl-CoA dehydrogenase activity
E4T53_RS12570	COG4670	ketone body catabolic process
E4T53_RS12585	COG2271	Major facilitator Superfamily
E4T53_RS12590	COG0738	Major facilitator superfamily
E4T53_RS12605	COG0628	permease
E4T53_RS12610	COG0277	FAD linked oxidase domain protein
E4T53_RS12610	COG0247	lactate metabolic process
E4T53_RS12615	COG2050	protein possibly involved in aromatic compounds catabolism
E4T53_RS12625	COG0316	Belongs to the HesB IscA family
E4T53_RS12630	COG0719	Fe-S assembly protein
E4T53_RS12635	COG0396	ATPase activity
E4T53_RS12640	COG0719	Fe-S assembly protein
E4T53_RS12655	COG1376	ErfK ybiS ycfS ynhG family protein
E4T53_RS12660	COG4238	major outer membrane lipoprotein
E4T53_RS12665	COG0469	pyruvate kinase activity
E4T53_RS12675	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS12680	COG2414	aldehyde ferredoxin oxidoreductase
E4T53_RS12690	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS12695	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4T53_RS12705	COG4529	Protein conserved in bacteria
E4T53_RS12725	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS12735	COG0307	riboflavin synthase, alpha
E4T53_RS12740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4T53_RS12745	COG2814	Major facilitator Superfamily
E4T53_RS12750	COG0583	DNA-binding transcription factor activity
E4T53_RS12765	COG2814	Major facilitator Superfamily
E4T53_RS12770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4T53_RS12775	COG0791	NLP P60 protein
E4T53_RS12780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4T53_RS12785	COG1201	RNA secondary structure unwinding
E4T53_RS12795	COG0346	lactoylglutathione lyase activity
E4T53_RS12800	COG1902	pentaerythritol trinitrate reductase activity
E4T53_RS12805	COG1309	transcriptional regulator
E4T53_RS12810	COG3313	Fe-S protein
E4T53_RS12820	COG2032	superoxide dismutase activity
E4T53_RS12825	COG1289	transmembrane transporter activity
E4T53_RS12830	COG1566	PFAM secretion protein HlyD family protein
E4T53_RS12845	COG3133	Outer membrane lipoprotein
E4T53_RS12855	COG3895	Periplasmic Protein
E4T53_RS12870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4T53_RS12875	COG0625	glutathione transferase activity
E4T53_RS12880	COG3104	oligopeptide transport
E4T53_RS12885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4T53_RS12895	COG4659	FMN binding
E4T53_RS12935	COG0673	inositol 2-dehydrogenase activity
E4T53_RS12945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4T53_RS12950	COG1263	PTS System
E4T53_RS12950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS12955	COG1609	Transcriptional regulator
E4T53_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS12965	COG1309	transcriptional regulator
E4T53_RS12985	COG5339	Protein conserved in bacteria
E4T53_RS12990	COG1482	cell wall glycoprotein biosynthetic process
E4T53_RS12995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS12995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS13000	COG0114	fumarate hydratase activity
E4T53_RS13010	COG2205	protein histidine kinase activity
E4T53_RS13015	COG0745	RESPONSE REGULATOR receiver
E4T53_RS13020	COG3136	membrane protein required for alginate biosynthesis
E4T53_RS13030	COG0531	amino acid
E4T53_RS13040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4T53_RS13045	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4T53_RS13050	COG0628	permease
E4T53_RS13065	COG3591	Belongs to the peptidase S1B family
E4T53_RS13080	COG2814	Major facilitator Superfamily
E4T53_RS13085	COG0583	DNA-binding transcription factor activity
E4T53_RS13090	COG1940	carbohydrate kinase activity
E4T53_RS13095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4T53_RS13105	COG3381	protein complex oligomerization
E4T53_RS13110	COG3302	dmso reductase anchor subunit
E4T53_RS13115	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS13120	COG0243	molybdopterin cofactor binding
E4T53_RS13125	COG0243	molybdopterin cofactor binding
E4T53_RS13140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T53_RS13165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS13220	COG1846	Transcriptional regulator
E4T53_RS13225	COG1484	DNA-dependent DNA replication
E4T53_RS13260	COG1403	HNH endonuclease
E4T53_RS13265	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4T53_RS13315	COG3772	lysozyme
E4T53_RS13450	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS13490	COG4372	Transposase
E4T53_RS13495	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS13545	COG3685	Protein conserved in bacteria
E4T53_RS13550	COG3685	Protein conserved in bacteria
E4T53_RS13555	COG3729	General stress protein
E4T53_RS13570	COG0135	phosphoribosylanthranilate isomerase activity
E4T53_RS13570	COG0134	indole-3-glycerol-phosphate synthase activity
E4T53_RS13575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4T53_RS13575	COG0512	Glutamine amidotransferase of anthranilate synthase
E4T53_RS13580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4T53_RS13590	COG0613	PHP domain protein
E4T53_RS13595	COG0009	L-threonylcarbamoyladenylate synthase
E4T53_RS13600	COG4907	membrane protein (DUF2207)
E4T53_RS13605	COG1187	pseudouridine synthase activity
E4T53_RS13610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4T53_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS13620	COG0616	signal peptide processing
E4T53_RS13630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4T53_RS13635	COG0583	DNA-binding transcription factor activity
E4T53_RS13655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4T53_RS13665	COG0671	phosphoesterase, PA-phosphatase related
E4T53_RS13670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E4T53_RS13675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4T53_RS13685	COG0023	Translation Initiation Factor
E4T53_RS13695	COG1349	DNA-binding transcription factor activity
E4T53_RS13705	COG5001	Diguanylate cyclase
E4T53_RS13715	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T53_RS13715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T53_RS13720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4T53_RS13730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS13745	COG2814	Major facilitator Superfamily
E4T53_RS13750	COG4172	Belongs to the ABC transporter superfamily
E4T53_RS13755	COG4172	Belongs to the ABC transporter superfamily
E4T53_RS13760	COG4171	peptide transport system, permease
E4T53_RS13765	COG4168	peptide transport system, permease
E4T53_RS13770	COG4166	transmembrane transport
E4T53_RS13780	COG0531	amino acid
E4T53_RS13790	COG0174	glutamine synthetase
E4T53_RS13795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4T53_RS13800	COG1917	Cupin 2, conserved barrel domain protein
E4T53_RS13800	COG1396	sequence-specific DNA binding
E4T53_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS13810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T53_RS13815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T53_RS13820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4T53_RS13825	COG1842	Phage shock protein A
E4T53_RS13835	COG1983	PspC domain protein
E4T53_RS13845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T53_RS13860	COG1175	transmembrane transport
E4T53_RS13865	COG0395	ABC-type sugar transport system, permease component
E4T53_RS13870	COG1063	alcohol dehydrogenase
E4T53_RS13875	COG1082	Xylose isomerase domain protein TIM barrel
E4T53_RS13880	COG0673	inositol 2-dehydrogenase activity
E4T53_RS13885	COG1554	hydrolase, family 65, central catalytic
E4T53_RS13890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T53_RS13895	COG3842	ATPase activity
E4T53_RS13905	COG1609	Transcriptional regulator
E4T53_RS13910	COG3106	COG3106 Predicted ATPase
E4T53_RS13920	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E4T53_RS13925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4T53_RS13930	COG4948	Mandelate Racemase Muconate Lactonizing
E4T53_RS13935	COG2866	Carboxypeptidase
E4T53_RS13940	COG0702	epimerase
E4T53_RS13945	COG1073	alpha beta
E4T53_RS13950	COG1073	alpha beta
E4T53_RS13955	COG0583	DNA-binding transcription factor activity
E4T53_RS13960	COG4166	transmembrane transport
E4T53_RS13965	COG0668	transmembrane transport
E4T53_RS13970	COG3182	Iron-regulated membrane protein
E4T53_RS13975	COG0589	response to stress
E4T53_RS13980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T53_RS13985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T53_RS13990	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4T53_RS13995	COG1473	amidohydrolase
E4T53_RS14000	COG1473	amidohydrolase
E4T53_RS14005	COG0583	DNA-binding transcription factor activity
E4T53_RS14010	COG2840	Smr protein MutS2
E4T53_RS14015	COG3706	GGDEF domain
E4T53_RS14030	COG0513	Belongs to the DEAD box helicase family
E4T53_RS14040	COG0589	response to stress
E4T53_RS14050	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4T53_RS14050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4T53_RS14050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T53_RS14050	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4T53_RS14055	COG3042	response to heat
E4T53_RS14060	COG3187	Heat shock protein
E4T53_RS14065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T53_RS14070	COG2911	Protein conserved in bacteria
E4T53_RS14080	COG3784	Protein of unknown function (DUF1318)
E4T53_RS14095	COG0667	Aldo Keto reductase
E4T53_RS14105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4T53_RS14110	COG4589	Belongs to the CDS family
E4T53_RS14115	COG2267	carboxylic ester hydrolase activity
E4T53_RS14120	COG2453	phosphatase
E4T53_RS14120	COG0671	phosphoesterase, PA-phosphatase related
E4T53_RS14125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T53_RS14130	COG1643	Atp-dependent helicase
E4T53_RS14155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4T53_RS14160	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS14165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4T53_RS14170	COG3038	cytochrome b561
E4T53_RS14185	COG0840	transmembrane signaling receptor activity
E4T53_RS14190	COG0583	DNA-binding transcription factor activity
E4T53_RS14195	COG5383	Protein conserved in bacteria
E4T53_RS14205	COG2841	Protein conserved in bacteria
E4T53_RS14215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4T53_RS14220	COG1275	C4-dicarboxylate transporter malic acid transport protein
E4T53_RS14225	COG0500	methyltransferase
E4T53_RS14235	COG3135	benzoate transporter
E4T53_RS14240	COG1396	sequence-specific DNA binding
E4T53_RS14245	COG0826	peptidase U32
E4T53_RS14255	COG1724	mRNA binding
E4T53_RS14260	COG1598	PFAM Uncharacterised protein family UPF0150
E4T53_RS14265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T53_RS14270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4T53_RS14275	COG3842	ATPase activity
E4T53_RS14280	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T53_RS14285	COG1177	transmembrane transport
E4T53_RS14310	COG3238	Protein conserved in bacteria
E4T53_RS14315	COG1247	-acetyltransferase
E4T53_RS14320	COG2130	NADP-dependent
E4T53_RS14325	COG1802	Transcriptional regulator
E4T53_RS14330	COG4772	TonB-dependent receptor
E4T53_RS14335	COG3391	amine dehydrogenase activity
E4T53_RS14340	COG1113	amino acid transport
E4T53_RS14345	COG0625	glutathione transferase activity
E4T53_RS14355	COG3501	Rhs element vgr protein
E4T53_RS14360	COG3209	COG3209 Rhs family protein
E4T53_RS14390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4T53_RS14400	COG0384	phenazine biosynthesis protein PhzF
E4T53_RS14405	COG2181	nitrate reductase activity
E4T53_RS14410	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4T53_RS14415	COG1140	nitrate reductase beta subunit
E4T53_RS14420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4T53_RS14425	COG2223	nitrite transmembrane transporter activity
E4T53_RS14430	COG4886	Leucine-rich repeat (LRR) protein
E4T53_RS14450	COG0697	spore germination
E4T53_RS14460	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS14465	COG2864	formate dehydrogenase
E4T53_RS14470	COG3093	addiction module antidote protein HigA
E4T53_RS14475	COG1064	alcohol dehydrogenase
E4T53_RS14495	COG1764	response to oxidative stress
E4T53_RS14500	COG4608	Belongs to the ABC transporter superfamily
E4T53_RS14505	COG0444	Belongs to the ABC transporter superfamily
E4T53_RS14510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T53_RS14515	COG0601	transmembrane transport
E4T53_RS14520	COG0747	negative chemotaxis
E4T53_RS14525	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4T53_RS14535	COG3706	GGDEF domain
E4T53_RS14545	COG0531	amino acid
E4T53_RS14550	COG0076	glutamate decarboxylase activity
E4T53_RS14555	COG0612	Peptidase, M16
E4T53_RS14560	COG4771	TonB-dependent receptor
E4T53_RS14565	COG4178	(ABC) transporter
E4T53_RS14575	COG0641	radical SAM
E4T53_RS14580	COG3119	arylsulfatase activity
E4T53_RS14585	COG2207	Transcriptional regulator
E4T53_RS14595	COG0243	molybdopterin cofactor binding
E4T53_RS14600	COG3539	Fimbrial protein
E4T53_RS14605	COG3539	Fimbrial protein
E4T53_RS14610	COG3539	Fimbrial protein
E4T53_RS14615	COG3188	usher protein
E4T53_RS14625	COG3539	Fimbrial protein
E4T53_RS14645	COG3210	domain, Protein
E4T53_RS14645	COG2911	Protein conserved in bacteria
E4T53_RS14650	COG1070	Carbohydrate kinase
E4T53_RS14660	COG1129	ABC transporter
E4T53_RS14665	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS14670	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS14680	COG1830	Aldolase
E4T53_RS14695	COG3781	membrane
E4T53_RS14705	COG2199	diguanylate cyclase activity
E4T53_RS14715	COG2066	Belongs to the glutaminase family
E4T53_RS14720	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS14725	COG0583	DNA-binding transcription factor activity
E4T53_RS14740	COG2814	Major facilitator Superfamily
E4T53_RS14745	COG2095	MarC family integral membrane protein
E4T53_RS14750	COG1846	Transcriptional regulator
E4T53_RS14755	COG4977	sequence-specific DNA binding
E4T53_RS14765	COG0697	spore germination
E4T53_RS14770	COG2814	Major facilitator Superfamily
E4T53_RS14790	COG3706	GGDEF domain
E4T53_RS14795	COG3111	PFAM Bacterial OB fold (BOF) protein
E4T53_RS14800	COG1546	Belongs to the CinA family
E4T53_RS14805	COG0339	signal peptide processing
E4T53_RS14810	COG4221	oxidoreductase activity
E4T53_RS14815	COG1802	Transcriptional regulator
E4T53_RS14825	COG0246	Mannitol dehydrogenase
E4T53_RS14830	COG0477	Major facilitator Superfamily
E4T53_RS14860	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS14945	COG1030	water channel activity
E4T53_RS14965	COG4220	transposase activity
E4T53_RS14995	COG3772	lysozyme
E4T53_RS15035	COG2207	Transcriptional regulator
E4T53_RS15050	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4T53_RS15055	COG1403	HNH endonuclease
E4T53_RS15065	COG3111	PFAM Bacterial OB fold (BOF) protein
E4T53_RS15100	COG1846	Transcriptional regulator
E4T53_RS15155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS15180	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS15185	COG4372	Transposase
E4T53_RS15210	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS15335	COG3772	lysozyme
E4T53_RS15380	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4T53_RS15385	COG1403	HNH endonuclease
E4T53_RS15415	COG1846	Transcriptional regulator
E4T53_RS15440	COG1396	sequence-specific DNA binding
E4T53_RS15480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS15490	COG0582	viral genome integration into host DNA
E4T53_RS15495	COG3047	cAMP biosynthetic process
E4T53_RS15515	COG1607	acyl-coa hydrolase
E4T53_RS15520	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4T53_RS15525	COG2350	Protein conserved in bacteria
E4T53_RS15530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4T53_RS15550	COG4608	Belongs to the ABC transporter superfamily
E4T53_RS15555	COG0444	Belongs to the ABC transporter superfamily
E4T53_RS15560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T53_RS15565	COG0601	transmembrane transport
E4T53_RS15570	COG4166	transmembrane transport
E4T53_RS15575	COG2095	MarC family integral membrane protein
E4T53_RS15580	COG1012	belongs to the aldehyde dehydrogenase family
E4T53_RS15580	COG1454	alcohol dehydrogenase
E4T53_RS15585	COG1435	thymidine kinase activity
E4T53_RS15595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4T53_RS15600	COG0745	RESPONSE REGULATOR receiver
E4T53_RS15605	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4T53_RS15615	COG0788	formyltetrahydrofolate deformylase activity
E4T53_RS15645	COG2181	nitrate reductase activity
E4T53_RS15650	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4T53_RS15655	COG1140	nitrate reductase beta subunit
E4T53_RS15660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4T53_RS15665	COG2223	nitrite transmembrane transporter activity
E4T53_RS15670	COG3850	Histidine kinase
E4T53_RS15675	COG2197	response regulator
E4T53_RS15680	COG4932	domain protein
E4T53_RS15685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4T53_RS15690	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4T53_RS15695	COG4572	Cation transport regulator
E4T53_RS15700	COG0387	Pfam Sodium calcium exchanger
E4T53_RS15720	COG2912	Transglutaminase-like superfamily
E4T53_RS15725	COG3094	Invasion gene expression up-regulator, SirB
E4T53_RS15755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4T53_RS15760	COG0659	secondary active sulfate transmembrane transporter activity
E4T53_RS15775	COG0012	GTP binding
E4T53_RS15780	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS15785	COG3284	Transcriptional regulator
E4T53_RS15790	COG2376	Dihydroxyacetone kinase
E4T53_RS15795	COG1461	Dihydroxyacetone kinase
E4T53_RS15800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T53_RS15800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS15800	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4T53_RS15825	COG1120	ATPase activity
E4T53_RS15835	COG0157	Belongs to the NadC ModD family
E4T53_RS15860	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4T53_RS15870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4T53_RS15880	COG2719	SpoVR family
E4T53_RS15895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4T53_RS15900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4T53_RS15905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4T53_RS15920	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4T53_RS15950	COG2894	cell division
E4T53_RS15975	COG4571	Outer membrane protease
E4T53_RS15985	COG4372	Transposase
E4T53_RS15990	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS16005	COG0500	methyltransferase
E4T53_RS16015	COG3729	General stress protein
E4T53_RS16020	COG3685	Protein conserved in bacteria
E4T53_RS16025	COG3685	Protein conserved in bacteria
E4T53_RS16030	COG3546	catalase activity
E4T53_RS16035	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4T53_RS16040	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS16125	COG1030	water channel activity
E4T53_RS16145	COG4220	transposase activity
E4T53_RS16160	COG5562	phage envelope protein
E4T53_RS16215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T53_RS16225	COG2076	Multidrug Resistance protein
E4T53_RS16250	COG0582	viral genome integration into host DNA
E4T53_RS16255	COG0538	isocitrate dehydrogenase activity
E4T53_RS16260	COG1187	pseudouridine synthase activity
E4T53_RS16270	COG0482	sulfurtransferase activity
E4T53_RS16280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4T53_RS16285	COG0745	RESPONSE REGULATOR receiver
E4T53_RS16290	COG2205	protein histidine kinase activity
E4T53_RS16300	COG4220	transposase activity
E4T53_RS16390	COG2850	peptidyl-arginine hydroxylation
E4T53_RS16400	COG3842	ATPase activity
E4T53_RS16595	COG3772	lysozyme
E4T53_RS16635	COG0484	heat shock protein binding
E4T53_RS16640	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4T53_RS16645	COG1403	HNH endonuclease
E4T53_RS16700	COG1846	Transcriptional regulator
E4T53_RS16720	COG4197	protein conserved in bacteria, prophage-related
E4T53_RS16750	COG0582	viral genome integration into host DNA
E4T53_RS16755	COG1177	transmembrane transport
E4T53_RS16760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4T53_RS16765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4T53_RS16775	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4T53_RS16780	COG1136	(ABC) transporter
E4T53_RS16785	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4T53_RS16790	COG4763	Acyl-transferase
E4T53_RS16795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4T53_RS16800	COG1376	ErfK ybiS ycfS ynhG family protein
E4T53_RS16800	COG1388	LysM domain
E4T53_RS16810	COG1309	transcriptional regulator
E4T53_RS16815	COG3134	Outer membrane lipoprotein
E4T53_RS16820	COG1252	NADH dehydrogenase
E4T53_RS16835	COG0510	thiamine kinase activity
E4T53_RS16840	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E4T53_RS16845	COG5633	Lipoprotein
E4T53_RS16850	COG0537	adenosine 5'-monophosphoramidase activity
E4T53_RS16860	COG4773	Receptor
E4T53_RS16865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS16865	COG1263	PTS System
E4T53_RS16870	COG0084	hydrolase, TatD family'
E4T53_RS16875	COG0470	DNA polymerase III
E4T53_RS16885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4T53_RS16890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T53_RS16895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T53_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS16910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4T53_RS16930	COG1399	metal-binding, possibly nucleic acid-binding protein
E4T53_RS16935	COG0424	maF-like protein
E4T53_RS16940	COG0564	pseudouridine synthase activity
E4T53_RS16945	COG1530	ribonuclease E activity
E4T53_RS16950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4T53_RS16955	COG1256	bacterial-type flagellum assembly
E4T53_RS16960	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4T53_RS16960	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4T53_RS16975	COG4786	Flagellar basal body rod
E4T53_RS16980	COG4787	bacterial-type flagellum-dependent cell motility
E4T53_RS16985	COG1749	Flagellar hook protein flgE
E4T53_RS16990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4T53_RS16995	COG1558	bacterial-type flagellum-dependent cell motility
E4T53_RS17000	COG1815	bacterial-type flagellum-dependent cell motility
E4T53_RS17005	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4T53_RS17010	COG2747	anti-sigma28 factor FlgM
E4T53_RS17015	COG3418	PFAM FlgN family protein
E4T53_RS17020	COG0728	peptidoglycan biosynthetic process
E4T53_RS17025	COG0673	inositol 2-dehydrogenase activity
E4T53_RS17035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4T53_RS17045	COG2999	glutathione oxidoreductase activity
E4T53_RS17080	COG3038	cytochrome b561
E4T53_RS17085	COG2353	YceI-like domain
E4T53_RS17095	COG1560	Kdo2-lipid A biosynthetic process
E4T53_RS17110	COG5645	(Lipo)protein
E4T53_RS17115	COG2943	transferase activity, transferring hexosyl groups
E4T53_RS17130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T53_RS17135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4T53_RS17160	COG2197	response regulator
E4T53_RS17175	COG1462	curli production assembly transport component CsgG
E4T53_RS17185	COG3381	protein complex oligomerization
E4T53_RS17235	COG2003	Belongs to the UPF0758 family
E4T53_RS17265	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS17365	COG4771	TonB-dependent receptor
E4T53_RS17425	COG1358	cellular component organization or biogenesis
E4T53_RS17460	COG4372	Transposase
E4T53_RS17465	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS17495	COG0254	rRNA binding
E4T53_RS17540	COG0829	nickel cation binding
E4T53_RS17550	COG2194	sulfuric ester hydrolase activity
E4T53_RS17555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4T53_RS17590	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS17595	COG4372	Transposase
E4T53_RS17625	COG4983	Phage plasmid primase, P4 family domain protein
E4T53_RS17650	COG0582	viral genome integration into host DNA
E4T53_RS17700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T53_RS17705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4T53_RS17715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T53_RS17725	COG0736	holo-[acyl-carrier-protein] synthase activity
E4T53_RS17730	COG2831	hemolysin activation secretion protein
E4T53_RS17735	COG3210	domain, Protein
E4T53_RS17745	COG3539	Fimbrial protein
E4T53_RS17755	COG3188	usher protein
E4T53_RS17765	COG3121	Chaperone
E4T53_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS17775	COG3710	Transcriptional regulator
E4T53_RS17785	COG2200	EAL domain
E4T53_RS17790	COG3706	GGDEF domain
E4T53_RS17795	COG0457	Tetratricopeptide repeat
E4T53_RS17800	COG0726	polysaccharide deacetylase
E4T53_RS17800	COG1649	PFAM Uncharacterised BCR, COG1649
E4T53_RS17805	COG1215	transferase activity, transferring glycosyl groups
E4T53_RS17810	COG3658	cytochrome
E4T53_RS17815	COG1702	phosphate starvation-inducible protein PhoH
E4T53_RS17820	COG2837	iron assimilation
E4T53_RS17825	COG2822	iron ion transport
E4T53_RS17840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T53_RS17850	COG0506	proline dehydrogenase activity
E4T53_RS17850	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4T53_RS17850	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4T53_RS17855	COG1309	transcriptional regulator
E4T53_RS17890	COG2233	PERMEase
E4T53_RS17895	COG3729	General stress protein
E4T53_RS17935	COG0243	molybdopterin cofactor binding
E4T53_RS17940	COG3005	denitrification pathway
E4T53_RS17945	COG0745	RESPONSE REGULATOR receiver
E4T53_RS17950	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS17955	COG0784	Response regulator, receiver
E4T53_RS17955	COG2198	Histidine kinase
E4T53_RS17955	COG2205	protein histidine kinase activity
E4T53_RS17960	COG0348	domain, Protein
E4T53_RS17980	COG1278	Cold shock
E4T53_RS17985	COG1278	Cold shock
E4T53_RS18005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T53_RS18010	COG1596	polysaccharide export
E4T53_RS18015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T53_RS18020	COG3206	protein involved in exopolysaccharide biosynthesis
E4T53_RS18020	COG0489	protein tyrosine kinase activity
E4T53_RS18035	COG1294	oxidase, subunit
E4T53_RS18040	COG1271	oxidase subunit
E4T53_RS18045	COG1773	rubredoxin
E4T53_RS18050	COG1999	signal sequence binding
E4T53_RS18055	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4T53_RS18060	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E4T53_RS18065	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4T53_RS18070	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4T53_RS18090	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS18105	COG2032	superoxide dismutase activity
E4T53_RS18190	COG4372	Transposase
E4T53_RS18195	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS18220	COG3772	lysozyme
E4T53_RS18270	COG2207	Transcriptional regulator
E4T53_RS18290	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4T53_RS18295	COG1403	HNH endonuclease
E4T53_RS18325	COG1846	Transcriptional regulator
E4T53_RS18330	COG1484	DNA-dependent DNA replication
E4T53_RS18395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS18410	COG0670	Belongs to the BI1 family
E4T53_RS18415	COG2920	part of a sulfur-relay system
E4T53_RS18420	COG1254	Belongs to the acylphosphatase family
E4T53_RS18435	COG1832	CoA-binding protein
E4T53_RS18450	COG0210	DNA helicase
E4T53_RS18455	COG3304	Inner membrane component domain
E4T53_RS18460	COG1289	transmembrane transporter activity
E4T53_RS18465	COG3070	regulator of competence-specific genes
E4T53_RS18475	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4T53_RS18475	COG2885	chlorophyll binding
E4T53_RS18485	COG1067	ATP-dependent peptidase activity
E4T53_RS18495	COG3130	regulation of translation
E4T53_RS18500	COG3009	Protein conserved in bacteria
E4T53_RS18505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4T53_RS18505	COG3008	intermembrane lipid transfer
E4T53_RS18510	COG2995	paraquat-inducible protein a
E4T53_RS18515	COG0488	(ABC) transporter
E4T53_RS18525	COG0633	Ferredoxin
E4T53_RS18525	COG3217	Mosc domain protein beta barrel domain protein
E4T53_RS18545	COG3539	Fimbrial protein
E4T53_RS18550	COG3539	Fimbrial protein
E4T53_RS18555	COG3539	Fimbrial protein
E4T53_RS18565	COG3121	Chaperone
E4T53_RS18570	COG3539	Fimbrial protein
E4T53_RS18575	COG0431	NADPH-dependent FMN reductase
E4T53_RS18580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T53_RS18590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T53_RS18595	COG1116	anion transmembrane transporter activity
E4T53_RS18600	COG0308	aminopeptidase N
E4T53_RS18610	COG0017	Asparaginyl-tRNA synthetase
E4T53_RS18615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4T53_RS18620	COG1448	Aminotransferase
E4T53_RS18625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T53_RS18630	COG3108	Peptidase M15
E4T53_RS18635	COG2989	Protein conserved in bacteria
E4T53_RS18645	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4T53_RS18655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4T53_RS18660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4T53_RS18665	COG3173	Aminoglycoside phosphotransferase
E4T53_RS18680	COG3214	Protein conserved in bacteria
E4T53_RS18690	COG1132	(ABC) transporter
E4T53_RS18695	COG2333	competence protein COMEC
E4T53_RS18695	COG0658	competence protein
E4T53_RS18705	COG0539	negative regulation of cytoplasmic translation
E4T53_RS18715	COG0501	Belongs to the peptidase M48B family
E4T53_RS18730	COG2323	membrane
E4T53_RS18735	COG1944	ATP diphosphatase activity
E4T53_RS18740	COG2116	formate transmembrane transporter activity
E4T53_RS18745	COG1882	Formate acetyltransferase
E4T53_RS18750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4T53_RS18760	COG0531	amino acid
E4T53_RS18770	COG1335	isochorismatase
E4T53_RS18775	COG3302	dmso reductase anchor subunit
E4T53_RS18780	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS18785	COG0243	molybdopterin cofactor binding
E4T53_RS18795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4T53_RS18805	COG1178	ABC-type Fe3 transport system permease component
E4T53_RS18805	COG1674	ftsk spoiiie
E4T53_RS18810	COG1522	sequence-specific DNA binding
E4T53_RS18815	COG0492	ferredoxin-NADP+ reductase activity
E4T53_RS18820	COG4988	ABC transporter
E4T53_RS18825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4T53_RS18845	COG0542	response to heat
E4T53_RS18855	COG1278	Cold shock
E4T53_RS18860	COG0577	efflux transmembrane transporter activity
E4T53_RS18860	COG1136	(ABC) transporter
E4T53_RS18865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS18870	COG2990	Protein conserved in bacteria
E4T53_RS18875	COG3593	DNA synthesis involved in DNA repair
E4T53_RS18880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4T53_RS18885	COG2431	L-lysine efflux transmembrane transporter activity
E4T53_RS18895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T53_RS18900	COG0028	Belongs to the TPP enzyme family
E4T53_RS18905	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4T53_RS18910	COG0702	epimerase
E4T53_RS18915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T53_RS18920	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4T53_RS18940	COG1126	abc transporter atp-binding protein
E4T53_RS18945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS18950	COG4215	(ABC) transporter
E4T53_RS18955	COG4160	amino acid transport
E4T53_RS18960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS18990	COG1177	transmembrane transport
E4T53_RS18995	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T53_RS19000	COG3842	ATPase activity
E4T53_RS19005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4T53_RS19020	COG0778	Nitroreductase
E4T53_RS19030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4T53_RS19045	COG3226	Transcriptional regulator
E4T53_RS19050	COG0738	Major facilitator superfamily
E4T53_RS19055	COG0561	phosphatase activity
E4T53_RS19065	COG2814	Major facilitator Superfamily
E4T53_RS19070	COG0671	phosphoesterase, PA-phosphatase related
E4T53_RS19075	COG1349	DNA-binding transcription factor activity
E4T53_RS19080	COG1686	Belongs to the peptidase S11 family
E4T53_RS19085	COG0625	glutathione transferase activity
E4T53_RS19090	COG2133	pyrroloquinoline quinone binding
E4T53_RS19115	COG2199	diguanylate cyclase activity
E4T53_RS19120	COG2200	EAL domain
E4T53_RS19130	COG0601	transmembrane transport
E4T53_RS19135	COG0747	negative chemotaxis
E4T53_RS19140	COG4172	Belongs to the ABC transporter superfamily
E4T53_RS19150	COG0303	'Molybdopterin
E4T53_RS19155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T53_RS19160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T53_RS19165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4T53_RS19175	COG0561	phosphatase activity
E4T53_RS19185	COG0488	(ABC) transporter
E4T53_RS19190	COG1376	ErfK ybiS ycfS ynhG family protein
E4T53_RS19195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4T53_RS19200	COG1321	iron dependent repressor
E4T53_RS19210	COG2194	sulfuric ester hydrolase activity
E4T53_RS19215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4T53_RS19225	COG5006	permease, DMT superfamily
E4T53_RS19235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS19240	COG0765	amino acid transport
E4T53_RS19245	COG1126	abc transporter atp-binding protein
E4T53_RS19250	COG0668	transmembrane transport
E4T53_RS19265	COG4774	siderophore transport
E4T53_RS19275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T53_RS19285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4T53_RS19290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4T53_RS19295	COG1199	ATP-dependent helicase activity
E4T53_RS19305	COG0513	Belongs to the DEAD box helicase family
E4T53_RS19310	COG1309	transcriptional regulator
E4T53_RS19320	COG1131	(ABC) transporter
E4T53_RS19325	COG0842	Transport permease protein
E4T53_RS19330	COG0842	Transport permease protein
E4T53_RS19340	COG3568	Endonuclease Exonuclease Phosphatase
E4T53_RS19345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T53_RS19350	COG0392	lysyltransferase activity
E4T53_RS19355	COG0670	Belongs to the BI1 family
E4T53_RS19360	COG0670	Belongs to the BI1 family
E4T53_RS19365	COG0314	molybdopterin synthase activity
E4T53_RS19370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4T53_RS19380	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T53_RS19390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4T53_RS19400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4T53_RS19405	COG2226	methyltransferase
E4T53_RS19420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4T53_RS19425	COG1881	PFAM PEBP family protein
E4T53_RS19465	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS19540	COG0740	serine-type endopeptidase activity
E4T53_RS19590	COG3772	lysozyme
E4T53_RS19695	COG0582	viral genome integration into host DNA
E4T53_RS19700	COG4677	pectinesterase activity
E4T53_RS19705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4T53_RS19710	COG0471	metal ion transport
E4T53_RS19715	COG2828	Protein conserved in bacteria
E4T53_RS19720	COG0583	DNA-binding transcription factor activity
E4T53_RS19730	COG0561	phosphatase activity
E4T53_RS19740	COG4149	molybdate abc transporter
E4T53_RS19745	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4T53_RS19755	COG2005	Transcriptional regulator
E4T53_RS19755	COG3585	molybdate ion transport
E4T53_RS19760	COG1119	ATPase activity
E4T53_RS19765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4T53_RS19770	COG1085	galactose-1-phosphate uridylyltransferase
E4T53_RS19780	COG2017	converts alpha-aldose to the beta-anomer
E4T53_RS19790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4T53_RS19800	COG1230	cation diffusion facilitator family transporter
E4T53_RS19805	COG3201	nicotinamide mononucleotide transporter
E4T53_RS19810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4T53_RS19845	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4T53_RS19850	COG2885	chlorophyll binding
E4T53_RS19860	COG3064	Membrane
E4T53_RS19865	COG0848	biopolymer transport protein
E4T53_RS19870	COG0811	peptide transport
E4T53_RS19875	COG0824	Thioesterase
E4T53_RS19880	COG3790	cyd operon protein YbgE
E4T53_RS19885	COG4890	Cyd operon protein YbgT
E4T53_RS19890	COG1294	oxidase, subunit
E4T53_RS19895	COG1271	oxidase subunit
E4T53_RS19910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4T53_RS19920	COG4865	methylaspartate mutase activity
E4T53_RS19925	COG3799	methylaspartate ammonia-lyase activity
E4T53_RS19940	COG1301	dicarboxylic acid transport
E4T53_RS19945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS19945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS19950	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4T53_RS19955	COG0583	DNA-binding transcription factor activity
E4T53_RS19960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4T53_RS19970	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4T53_RS19975	COG0567	Dehydrogenase, E1 component
E4T53_RS19980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4T53_RS19985	COG1053	succinate dehydrogenase
E4T53_RS19990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4T53_RS19995	COG2009	succinate dehydrogenase
E4T53_RS20005	COG0372	Belongs to the citrate synthase family
E4T53_RS20010	COG3539	Fimbrial protein
E4T53_RS20015	COG3188	usher protein
E4T53_RS20020	COG3121	Chaperone
E4T53_RS20025	COG3539	Fimbrial protein
E4T53_RS20030	COG3180	Ammonia monooxygenase
E4T53_RS20035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4T53_RS20045	COG1984	allophanate hydrolase subunit 2
E4T53_RS20050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4T53_RS20055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4T53_RS20060	COG3104	oligopeptide transport
E4T53_RS20065	COG0415	Belongs to the DNA photolyase family
E4T53_RS20070	COG3272	Protein of unknown function (DUF1722)
E4T53_RS20090	COG3209	COG3209 Rhs family protein
E4T53_RS20120	COG2205	protein histidine kinase activity
E4T53_RS20125	COG0745	RESPONSE REGULATOR receiver
E4T53_RS20135	COG1982	Orn Lys Arg decarboxylase major
E4T53_RS20140	COG0531	amino acid
E4T53_RS20145	COG0033	Phosphoglucomutase
E4T53_RS20150	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4T53_RS20155	COG0596	Alpha beta hydrolase
E4T53_RS20165	COG0716	FMN binding
E4T53_RS20175	COG0735	belongs to the Fur family
E4T53_RS20195	COG2190	(PTS) system
E4T53_RS20195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS20195	COG1263	PTS System
E4T53_RS20205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4T53_RS20210	COG1940	carbohydrate kinase activity
E4T53_RS20210	COG1846	Transcriptional regulator
E4T53_RS20215	COG0647	UMP catabolic process
E4T53_RS20220	COG0367	asparagine synthase
E4T53_RS20260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T53_RS20270	COG1702	phosphate starvation-inducible protein PhoH
E4T53_RS20280	COG4535	Mg2 and Co2 transporter CorC
E4T53_RS20285	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4T53_RS20290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T53_RS20295	COG0765	amino acid transport
E4T53_RS20300	COG0765	amino acid transport
E4T53_RS20305	COG1126	abc transporter atp-binding protein
E4T53_RS20315	COG0443	Heat shock 70 kDa protein
E4T53_RS20330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4T53_RS20335	COG2214	Heat shock protein DnaJ domain protein
E4T53_RS20350	COG2888	peptidyl-tyrosine sulfation
E4T53_RS20365	COG1466	dna polymerase III delta subunit
E4T53_RS20375	COG0406	alpha-ribazole phosphatase activity
E4T53_RS20380	COG0799	negative regulation of ribosome biogenesis
E4T53_RS20390	COG0768	penicillin binding
E4T53_RS20395	COG0772	Belongs to the SEDS family
E4T53_RS20400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4T53_RS20405	COG1686	Belongs to the peptidase S11 family
E4T53_RS20420	COG0583	DNA-binding transcription factor activity
E4T53_RS20430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T53_RS20435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T53_RS20455	COG3069	C4-dicarboxylate transmembrane transporter activity
E4T53_RS20460	COG4565	transcriptional regulatory protein
E4T53_RS20465	COG3290	protein histidine kinase activity
E4T53_RS20470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4T53_RS20480	COG2301	Belongs to the HpcH HpaI aldolase family
E4T53_RS20485	COG3051	citrate lyase alpha subunit
E4T53_RS20500	COG0471	metal ion transport
E4T53_RS20505	COG3719	Belongs to the RNase T2 family
E4T53_RS20510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T53_RS20515	COG1063	alcohol dehydrogenase
E4T53_RS20520	COG0589	response to stress
E4T53_RS20525	COG3634	alkyl hydroperoxide reductase activity
E4T53_RS20530	COG0450	alkyl hydroperoxide reductase
E4T53_RS20535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4T53_RS20540	COG0583	DNA-binding transcription factor activity
E4T53_RS20545	COG3969	phosphoadenosine phosphosulfate
E4T53_RS20550	COG1475	DNA binding
E4T53_RS20555	COG0436	Aminotransferase
E4T53_RS20560	COG0371	Dehydrogenase
E4T53_RS20565	COG2879	small protein
E4T53_RS20570	COG1966	Carbon starvation protein
E4T53_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS20585	COG1535	isochorismatase
E4T53_RS20585	COG3433	isochorismatase activity
E4T53_RS20590	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4T53_RS20595	COG1169	isochorismate synthase
E4T53_RS20600	COG4592	Periplasmic binding protein
E4T53_RS20610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T53_RS20615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T53_RS20620	COG1120	ATPase activity
E4T53_RS20625	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4T53_RS20630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T53_RS20630	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4T53_RS20635	COG3251	PFAM MbtH domain protein
E4T53_RS20640	COG2382	esterase
E4T53_RS20645	COG4771	TonB-dependent receptor
E4T53_RS20650	COG2977	Belongs to the P-Pant transferase superfamily
E4T53_RS20675	COG2315	Protein conserved in bacteria
E4T53_RS20680	COG0778	Nitroreductase
E4T53_RS20685	COG0668	transmembrane transport
E4T53_RS20690	COG1113	amino acid transport
E4T53_RS20695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T53_RS20700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS20705	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS20710	COG1538	Outer membrane efflux protein
E4T53_RS20715	COG0745	RESPONSE REGULATOR receiver
E4T53_RS20720	COG5002	protein histidine kinase activity
E4T53_RS20725	COG3501	Rhs element vgr protein
E4T53_RS20735	COG4104	PAAR repeat-containing protein
E4T53_RS20735	COG3209	COG3209 Rhs family protein
E4T53_RS20745	COG3209	COG3209 Rhs family protein
E4T53_RS20745	COG4104	PAAR repeat-containing protein
E4T53_RS20755	COG5433	transposase activity
E4T53_RS20760	COG1215	transferase activity, transferring glycosyl groups
E4T53_RS20765	COG4783	chaperone-mediated protein folding
E4T53_RS20775	COG2207	Transcriptional regulator
E4T53_RS20785	COG2197	response regulator
E4T53_RS20790	COG3539	Fimbrial protein
E4T53_RS20795	COG3539	Fimbrial protein
E4T53_RS20800	COG3188	usher protein
E4T53_RS20805	COG3121	Chaperone
E4T53_RS20810	COG3539	Fimbrial protein
E4T53_RS20820	COG2501	S4 domain
E4T53_RS20825	COG1988	membrane-bound metal-dependent
E4T53_RS20835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4T53_RS20845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4T53_RS20850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4T53_RS20855	COG0549	Belongs to the carbamate kinase family
E4T53_RS20865	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4T53_RS20870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4T53_RS20875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4T53_RS20880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T53_RS20885	COG3257	ureidoglycine aminohydrolase activity
E4T53_RS20890	COG1929	Belongs to the glycerate kinase type-1 family
E4T53_RS20895	COG2233	PERMEase
E4T53_RS20905	COG1953	Uracil, thiamine, allantoin
E4T53_RS20915	COG3622	Belongs to the hyi family
E4T53_RS20920	COG3960	tartronate-semialdehyde synthase activity
E4T53_RS20925	COG1414	Transcriptional regulator
E4T53_RS20935	COG0583	DNA-binding transcription factor activity
E4T53_RS20955	COG3209	COG3209 Rhs family protein
E4T53_RS20960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4T53_RS20965	COG4181	ATPase activity
E4T53_RS20970	COG2755	lipolytic protein G-D-S-L family
E4T53_RS20975	COG0300	oxidoreductase activity
E4T53_RS20980	COG3118	belongs to the thioredoxin family
E4T53_RS20985	COG0390	transport system, permease component
E4T53_RS20990	COG4619	ABC transporter
E4T53_RS20995	COG0330	HflC and HflK could
E4T53_RS21000	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4T53_RS21020	COG0789	Transcriptional regulator
E4T53_RS21045	COG0531	amino acid
E4T53_RS21050	COG2066	Belongs to the glutaminase family
E4T53_RS21055	COG2217	Heavy metal translocating P-type atpase
E4T53_RS21060	COG3093	addiction module antidote protein HigA
E4T53_RS21065	COG3735	TraB family
E4T53_RS21070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4T53_RS21075	COG0737	Belongs to the 5'-nucleotidase family
E4T53_RS21080	COG2223	nitrite transmembrane transporter activity
E4T53_RS21085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4T53_RS21085	COG4651	solute:proton antiporter activity
E4T53_RS21090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS21125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4T53_RS21135	COG2832	Protein of unknown function (DUF454)
E4T53_RS21140	COG3923	Primosomal replication protein n
E4T53_RS21150	COG3264	Mechanosensitive ion channel
E4T53_RS21150	COG1196	nuclear chromosome segregation
E4T53_RS21155	COG1309	transcriptional regulator
E4T53_RS21160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T53_RS21165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T53_RS21180	COG0110	maltose O-acetyltransferase activity
E4T53_RS21190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4T53_RS21195	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4T53_RS21205	COG3695	enzyme binding
E4T53_RS21210	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E4T53_RS21215	COG1946	Acyl-CoA thioesterase
E4T53_RS21220	COG0004	ammonium transporteR
E4T53_RS21225	COG0347	Belongs to the P(II) protein family
E4T53_RS21230	COG1132	(ABC) transporter
E4T53_RS21235	COG1132	(ABC) transporter
E4T53_RS21240	COG1522	sequence-specific DNA binding
E4T53_RS21250	COG4533	DNA binding
E4T53_RS21260	COG0824	Thioesterase
E4T53_RS21265	COG1555	photosystem II stabilization
E4T53_RS21270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T53_RS21275	COG0776	regulation of translation
E4T53_RS21280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4T53_RS21300	COG0271	Belongs to the BolA IbaG family
E4T53_RS21305	COG3056	Lipoprotein
E4T53_RS21310	COG2223	nitrite transmembrane transporter activity
E4T53_RS21315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T53_RS21320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T53_RS21325	COG1845	cytochrome c oxidase, subunit III
E4T53_RS21330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4T53_RS21340	COG2814	Major facilitator Superfamily
E4T53_RS21350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4T53_RS21355	COG0693	protein deglycase activity
E4T53_RS21370	COG0142	geranyltranstransferase activity
E4T53_RS21380	COG0667	Aldo Keto reductase
E4T53_RS21390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4T53_RS21395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4T53_RS21410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T53_RS21410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T53_RS21420	COG4238	major outer membrane lipoprotein
E4T53_RS21425	COG3248	Nucleoside-binding outer membrane protein
E4T53_RS21430	COG1403	HNH endonuclease
E4T53_RS21440	COG3609	addiction module antidote protein, CC2985 family
E4T53_RS21445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4T53_RS21450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4T53_RS21455	COG1862	Preprotein translocase
E4T53_RS21480	COG0366	Alpha amylase catalytic
E4T53_RS21485	COG1113	amino acid transport
E4T53_RS21490	COG1114	Component of the transport system for branched-chain amino acids
E4T53_RS21495	COG5002	protein histidine kinase activity
E4T53_RS21500	COG0745	RESPONSE REGULATOR receiver
E4T53_RS21505	COG0420	3'-5' exonuclease activity
E4T53_RS21510	COG0419	ATPase involved in DNA repair
E4T53_RS21515	COG2814	Major facilitator Superfamily
E4T53_RS21520	COG1940	carbohydrate kinase activity
E4T53_RS21545	COG4126	flavin adenine dinucleotide binding
E4T53_RS21565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4T53_RS21570	COG3706	GGDEF domain
E4T53_RS21580	COG1785	Belongs to the alkaline phosphatase family
E4T53_RS21595	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4T53_RS21615	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4T53_RS21620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T53_RS21625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T53_RS21630	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS21635	COG0113	porphobilinogen synthase activity
E4T53_RS21640	COG2175	clavaminate synthase activity
E4T53_RS21645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T53_RS21650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4T53_RS21655	COG4521	taurine ABC transporter
E4T53_RS21670	COG2271	Major facilitator Superfamily
E4T53_RS21675	COG1840	ABC-type Fe3 transport system, periplasmic component
E4T53_RS21685	COG3842	ATPase activity
E4T53_RS21700	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4T53_RS21705	COG3122	Protein conserved in bacteria
E4T53_RS21710	COG2814	Major facilitator Superfamily
E4T53_RS21715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4T53_RS21730	COG0596	Alpha beta hydrolase
E4T53_RS21745	COG1414	Transcriptional regulator
E4T53_RS21750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4T53_RS21760	COG1609	Transcriptional regulator
E4T53_RS21765	COG3250	beta-galactosidase activity
E4T53_RS21770	COG2223	nitrite transmembrane transporter activity
E4T53_RS21775	COG0110	maltose O-acetyltransferase activity
E4T53_RS21780	COG2807	transmembrane transport
E4T53_RS21790	COG0288	reversible hydration of carbon dioxide
E4T53_RS21795	COG0583	DNA-binding transcription factor activity
E4T53_RS21800	COG0402	S-adenosylhomocysteine deaminase activity
E4T53_RS21805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T53_RS21810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T53_RS21815	COG2079	MmgE PrpD family protein
E4T53_RS21820	COG0372	Belongs to the citrate synthase family
E4T53_RS21825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4T53_RS21830	COG3829	transcription factor binding
E4T53_RS21840	COG1280	lysine exporter protein (LysE YggA)
E4T53_RS21855	COG1064	alcohol dehydrogenase
E4T53_RS21865	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS21870	COG1129	ABC transporter
E4T53_RS21875	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS21885	COG0402	S-adenosylhomocysteine deaminase activity
E4T53_RS21890	COG0549	Belongs to the carbamate kinase family
E4T53_RS21900	COG1304	FMN binding
E4T53_RS21905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4T53_RS21915	COG0666	response to abiotic stimulus
E4T53_RS21930	COG2200	EAL domain
E4T53_RS21930	COG2771	luxR family
E4T53_RS21940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T53_RS21975	COG2771	luxR family
E4T53_RS21975	COG2200	EAL domain
E4T53_RS22000	COG1556	Lactate utilization protein
E4T53_RS22005	COG1139	Iron-sulfur cluster binding protein
E4T53_RS22010	COG0247	lactate metabolic process
E4T53_RS22015	COG2207	Transcriptional regulator
E4T53_RS22020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T53_RS22030	COG3059	membrane
E4T53_RS22035	COG0656	L-ascorbic acid biosynthetic process
E4T53_RS22040	COG2207	Transcriptional regulator
E4T53_RS22040	COG3708	Transcriptional regulator
E4T53_RS22045	COG1388	LysM domain
E4T53_RS22060	COG0583	DNA-binding transcription factor activity
E4T53_RS22065	COG1073	alpha beta
E4T53_RS22070	COG1902	pentaerythritol trinitrate reductase activity
E4T53_RS22080	COG4372	Transposase
E4T53_RS22085	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS22125	COG3188	usher protein
E4T53_RS22135	COG3121	Chaperone
E4T53_RS22140	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4T53_RS22145	COG3477	response to acidic pH
E4T53_RS22150	COG2080	2 iron, 2 sulfur cluster binding
E4T53_RS22155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4T53_RS22160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T53_RS22165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T53_RS22180	COG0583	DNA-binding transcription factor activity
E4T53_RS22190	COG4221	oxidoreductase activity
E4T53_RS22195	COG0583	DNA-binding transcription factor activity
E4T53_RS22300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T53_RS22320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4T53_RS22390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4T53_RS22410	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4T53_RS22415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4T53_RS22420	COG1690	Belongs to the RtcB family
E4T53_RS22425	COG0454	-acetyltransferase
E4T53_RS22435	COG2161	toxin-antitoxin pair type II binding
E4T53_RS22440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4T53_RS22460	COG0791	NLP P60 protein
E4T53_RS22465	COG3077	Addiction module antitoxin, RelB DinJ family
E4T53_RS22470	COG3041	Addiction module toxin RelE StbE family
E4T53_RS22475	COG3034	peptidoglycan biosynthetic process
E4T53_RS22480	COG0121	glutamine amidotransferase
E4T53_RS22490	COG1960	acyl-CoA dehydrogenase activity
E4T53_RS22500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T53_RS22505	COG5433	transposase activity
E4T53_RS22520	COG3209	COG3209 Rhs family protein
E4T53_RS22525	COG5433	transposase activity
E4T53_RS22535	COG3209	COG3209 Rhs family protein
E4T53_RS22545	COG3209	COG3209 Rhs family protein
E4T53_RS22550	COG3501	Rhs element vgr protein
E4T53_RS22660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T53_RS22670	COG2226	methyltransferase
E4T53_RS22680	COG0741	lytic transglycosylase activity
E4T53_RS22680	COG1388	LysM domain
E4T53_RS22685	COG2226	methyltransferase
E4T53_RS22695	COG0583	DNA-binding transcription factor activity
E4T53_RS22700	COG0656	L-ascorbic acid biosynthetic process
E4T53_RS22735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4T53_RS22740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4T53_RS22745	COG2011	ABC-type metal ion transport system permease component
E4T53_RS22750	COG1464	Belongs to the NlpA lipoprotein family
E4T53_RS22760	COG1720	tRNA m6t6A37 methyltransferase activity
E4T53_RS22770	COG0791	NLP P60 protein
E4T53_RS22775	COG3015	lipoprotein NlpE involved in copper resistance
E4T53_RS22780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4T53_RS22785	COG4681	YaeQ
E4T53_RS22795	COG4568	rho-dependent transcription termination
E4T53_RS22800	COG0037	tRNA processing
E4T53_RS22805	COG0346	lactoylglutathione lyase activity
E4T53_RS22820	COG0587	DNA-directed DNA polymerase activity
E4T53_RS22845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T53_RS22850	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E4T53_RS22860	COG0750	zinc metalloprotease
E4T53_RS22865	COG0575	Belongs to the CDS family
E4T53_RS22870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4T53_RS22875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4T53_RS22900	COG0024	Methionine aminopeptidase
E4T53_RS22920	COG3835	regulator
E4T53_RS22925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T53_RS22940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T53_RS22945	COG2860	membrane
E4T53_RS22970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T53_RS22975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T53_RS22980	COG1120	ATPase activity
E4T53_RS22985	COG4774	siderophore transport
E4T53_RS22990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T53_RS22995	COG1643	Atp-dependent helicase
E4T53_RS23000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4T53_RS23010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T53_RS23015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4T53_RS23020	COG0617	tRNA 3'-terminal CCA addition
E4T53_RS23025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4T53_RS23035	COG3121	Chaperone
E4T53_RS23040	COG3188	usher protein
E4T53_RS23045	COG3539	Fimbrial protein
E4T53_RS23050	COG3539	Fimbrial protein
E4T53_RS23075	COG5464	transposase or invertase
E4T53_RS23085	COG0726	polysaccharide deacetylase
E4T53_RS23090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS23095	COG0842	Transport permease protein
E4T53_RS23100	COG1131	(ABC) transporter
E4T53_RS23105	COG0288	reversible hydration of carbon dioxide
E4T53_RS23110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4T53_RS23115	COG4993	Dehydrogenase
E4T53_RS23120	COG2132	Multicopper oxidase
E4T53_RS23145	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4T53_RS23150	COG3064	Membrane
E4T53_RS23155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T53_RS23160	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4T53_RS23165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4T53_RS23170	COG2186	Transcriptional regulator
E4T53_RS23175	COG1113	amino acid transport
E4T53_RS23180	COG3725	Membrane protein required for beta-lactamase induction
E4T53_RS23185	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4T53_RS23190	COG0157	Belongs to the NadC ModD family
E4T53_RS23195	COG4969	Belongs to the N-Me-Phe pilin family
E4T53_RS23200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4T53_RS23205	COG1459	type II secretion system
E4T53_RS23215	COG0237	dephospho-CoA kinase activity
E4T53_RS23230	COG0494	nUDIX hydrolase
E4T53_RS23250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4T53_RS23255	COG0849	cell division
E4T53_RS23260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4T53_RS23265	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4T53_RS23280	COG0772	Belongs to the SEDS family
E4T53_RS23285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4T53_RS23295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4T53_RS23300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4T53_RS23305	COG0768	penicillin binding
E4T53_RS23310	COG3116	cell division
E4T53_RS23325	COG1609	Transcriptional regulator
E4T53_RS23335	COG0440	acetolactate synthase activity
E4T53_RS23340	COG0028	Belongs to the TPP enzyme family
E4T53_RS23345	COG0583	DNA-binding transcription factor activity
E4T53_RS23360	COG0473	3-isopropylmalate dehydrogenase activity
E4T53_RS23380	COG4533	DNA binding
E4T53_RS23390	COG4143	(ABC) transporter
E4T53_RS23395	COG1178	ABC-type Fe3 transport system permease component
E4T53_RS23400	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4T53_RS23405	COG0586	Pfam SNARE associated Golgi protein
E4T53_RS23410	COG4977	sequence-specific DNA binding
E4T53_RS23425	COG0235	Class ii aldolase
E4T53_RS23430	COG0417	DNA replication proofreading
E4T53_RS23440	COG0564	pseudouridine synthase activity
E4T53_RS23450	COG1357	PFAM Pentapeptide repeats (8 copies)
E4T53_RS23455	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4T53_RS23460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4T53_RS23465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T53_RS23500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4T53_RS23515	COG2271	Major facilitator Superfamily
E4T53_RS23520	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4T53_RS23525	COG0644	oxidoreductase
E4T53_RS23560	COG1024	Enoyl-CoA hydratase
E4T53_RS23575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4T53_RS23580	COG0505	Belongs to the CarA family
E4T53_RS23600	COG1047	Peptidyl-prolyl cis-trans
E4T53_RS23615	COG0196	riboflavin kinase activity
E4T53_RS23640	COG3121	Chaperone
E4T53_RS23645	COG3188	usher protein
E4T53_RS23655	COG0583	DNA-binding transcription factor activity
E4T53_RS23685	COG4735	regulation of single-species biofilm formation
E4T53_RS23690	COG1584	GPR1 FUN34 yaaH family protein
E4T53_RS23695	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T53_RS23700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T53_RS23705	COG1115	amino acid carrier protein
E4T53_RS23720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4T53_RS23730	COG0460	homoserine dehydrogenase
E4T53_RS23730	COG0527	aspartate kinase activity
E4T53_RS23740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4T53_RS23750	COG0745	RESPONSE REGULATOR receiver
E4T53_RS23755	COG4452	Inner membrane protein CreD
E4T53_RS23760	COG2205	protein histidine kinase activity
E4T53_RS23765	COG0745	RESPONSE REGULATOR receiver
E4T53_RS23770	COG3045	CreA protein
E4T53_RS23775	COG2207	Transcriptional regulator
E4T53_RS23775	COG3708	Transcriptional regulator
E4T53_RS23785	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E4T53_RS23795	COG0741	lytic transglycosylase activity
E4T53_RS23800	COG0488	(ABC) transporter
E4T53_RS23810	COG1056	cytidyltransferase-related domain
E4T53_RS23810	COG3172	ATPase kinase involved in NAD metabolism
E4T53_RS23815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4T53_RS23820	COG0560	Phosphoserine phosphatase
E4T53_RS23830	COG0095	Lipoate-protein ligase
E4T53_RS23830	COG3726	membrane protein affecting hemolysin expression
E4T53_RS23865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4T53_RS23870	COG0084	hydrolase, TatD family'
E4T53_RS23875	COG4667	esterase of the alpha-beta hydrolase superfamily
E4T53_RS23885	COG2823	Periplasmic or secreted lipoprotein
E4T53_RS23895	COG1011	Hydrolase
E4T53_RS23900	COG0456	acetyltransferase
E4T53_RS23905	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E4T53_RS23925	COG4114	ferric iron reductase
E4T53_RS23930	COG2197	response regulator
E4T53_RS23935	COG2197	response regulator
E4T53_RS23940	COG2966	Psort location CytoplasmicMembrane, score
E4T53_RS23955	COG1484	DNA-dependent DNA replication
E4T53_RS23970	COG1063	alcohol dehydrogenase
E4T53_RS23975	COG1802	Transcriptional regulator
E4T53_RS23980	COG2271	Major facilitator Superfamily
E4T53_RS23985	COG0840	transmembrane signaling receptor activity
E4T53_RS23995	COG1966	Carbon starvation protein
E4T53_RS24000	COG2879	small protein
E4T53_RS24005	COG0523	cobalamin synthesis protein
E4T53_RS24030	COG0732	type I restriction modification DNA specificity domain
E4T53_RS24050	COG5457	Domain of unknown function (DUF1127)
E4T53_RS24075	COG5464	transposase or invertase
E4T53_RS24080	COG2814	Major facilitator Superfamily
E4T53_RS24085	COG2733	membrane
E4T53_RS24090	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4T53_RS24095	COG1924	4 iron, 4 sulfur cluster binding
E4T53_RS24110	COG3204	pilus organization
E4T53_RS24115	COG0477	Major facilitator Superfamily
E4T53_RS24130	COG3366	ferrous iron transmembrane transporter activity
E4T53_RS24135	COG0700	Nucleoside recognition
E4T53_RS24140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4T53_RS24165	COG2186	Transcriptional regulator
E4T53_RS24170	COG0246	Mannitol dehydrogenase
E4T53_RS24180	COG2610	gluconate transmembrane transporter activity
E4T53_RS24185	COG3539	Fimbrial protein
E4T53_RS24190	COG3539	Fimbrial protein
E4T53_RS24195	COG3539	Fimbrial protein
E4T53_RS24200	COG3188	usher protein
E4T53_RS24205	COG3121	Chaperone
E4T53_RS24210	COG3539	Fimbrial protein
E4T53_RS24215	COG3539	Fimbrial protein
E4T53_RS24220	COG4974	Belongs to the 'phage' integrase family
E4T53_RS24225	COG0582	viral genome integration into host DNA
E4T53_RS24230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4T53_RS24235	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E4T53_RS24250	COG0210	DNA helicase
E4T53_RS24255	COG1205	dead DEAH box helicase
E4T53_RS24255	COG1111	helicase
E4T53_RS24265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T53_RS24310	COG0582	viral genome integration into host DNA
E4T53_RS24360	COG1064	alcohol dehydrogenase
E4T53_RS24365	COG0433	COG0433 Predicted ATPase
E4T53_RS24370	COG0795	lipopolysaccharide-transporting ATPase activity
E4T53_RS24375	COG0795	lipopolysaccharide-transporting ATPase activity
E4T53_RS24385	COG2927	DNA polymerase III (CHI subunit)
E4T53_RS24395	COG4269	membrane
E4T53_RS24400	COG0456	acetyltransferase
E4T53_RS24405	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4T53_RS24410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4T53_RS24420	COG2731	YhcH YjgK YiaL family protein
E4T53_RS24425	COG1309	transcriptional regulator
E4T53_RS24430	COG1028	Short-chain dehydrogenase reductase Sdr
E4T53_RS24435	COG0251	oxidation-reduction process
E4T53_RS24455	COG0251	oxidation-reduction process
E4T53_RS24460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4T53_RS24470	COG1609	Transcriptional regulator
E4T53_RS24475	COG1263	PTS System
E4T53_RS24475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T53_RS24480	COG0366	Alpha amylase catalytic
E4T53_RS24485	COG1328	CTP reductase activity
E4T53_RS24490	COG0602	queuosine metabolic process
E4T53_RS24495	COG3783	Cytochrome b(562)
E4T53_RS24500	COG0312	modulator of DNA gyrase
E4T53_RS24510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4T53_RS24520	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS24525	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS24530	COG1129	ABC transporter
E4T53_RS24535	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS24540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4T53_RS24545	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4T53_RS24550	COG2336	PFAM SpoVT AbrB
E4T53_RS24555	COG2105	PFAM AIG2 family protein
E4T53_RS24560	COG2911	Protein conserved in bacteria
E4T53_RS24565	COG0729	surface antigen
E4T53_RS24575	COG1253	flavin adenine dinucleotide binding
E4T53_RS24585	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4T53_RS24595	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4T53_RS24600	COG0737	Belongs to the 5'-nucleotidase family
E4T53_RS24605	COG1733	regulation of RNA biosynthetic process
E4T53_RS24610	COG0702	epimerase
E4T53_RS24615	COG0697	spore germination
E4T53_RS24625	COG1113	amino acid transport
E4T53_RS24630	COG0545	Peptidyl-prolyl cis-trans isomerase
E4T53_RS24635	COG3061	Opacity-associated protein A
E4T53_RS24645	COG0675	Transposase, IS605 OrfB family
E4T53_RS24670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4T53_RS24705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS24710	COG3414	Phosphotransferase system galactitol-specific IIB component
E4T53_RS24730	COG1073	alpha beta
E4T53_RS24735	COG3650	response to hydrogen peroxide
E4T53_RS24745	COG1960	acyl-CoA dehydrogenase activity
E4T53_RS24750	COG0754	glutathionylspermidine amidase activity
E4T53_RS24755	COG5463	Belongs to the UPF0441 family
E4T53_RS24760	COG3766	membrane
E4T53_RS24770	COG1842	Phage shock protein A
E4T53_RS24775	COG3789	protein conserved in bacteria
E4T53_RS24780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T53_RS24785	COG0557	exoribonuclease II activity
E4T53_RS24800	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4T53_RS24805	COG0330	HflC and HflK could
E4T53_RS24810	COG0330	HflC and HflK could
E4T53_RS24815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4T53_RS24835	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T53_RS24840	COG0802	atpase or kinase
E4T53_RS24845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4T53_RS24845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4T53_RS24875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4T53_RS24890	COG1511	domain protein
E4T53_RS24890	COG3264	Mechanosensitive ion channel
E4T53_RS24895	COG0531	amino acid
E4T53_RS24905	COG1053	succinate dehydrogenase
E4T53_RS24910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4T53_RS24925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T53_RS24930	COG3040	lipid binding
E4T53_RS24935	COG2076	Multidrug Resistance protein
E4T53_RS24940	COG5510	response to toxic substance
E4T53_RS24945	COG5510	response to toxic substance
E4T53_RS24955	COG1509	lysine 2,3-aminomutase activity
E4T53_RS24980	COG0531	amino acid
E4T53_RS24985	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4T53_RS24990	COG1027	Aspartate ammonia-lyase
E4T53_RS24995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4T53_RS25005	COG4232	protein-disulfide reductase activity
E4T53_RS25010	COG1309	transcriptional regulator
E4T53_RS25020	COG3710	Transcriptional regulator
E4T53_RS25025	COG0531	amino acid
E4T53_RS25030	COG1982	Orn Lys Arg decarboxylase major
E4T53_RS25035	COG3104	oligopeptide transport
E4T53_RS25040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4T53_RS25055	COG2388	GCN5-related N-acetyl-transferase
E4T53_RS25060	COG3592	Divergent 4Fe-4S mono-cluster
E4T53_RS25065	COG3290	protein histidine kinase activity
E4T53_RS25070	COG4565	transcriptional regulatory protein
E4T53_RS25075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4T53_RS25080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS25080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4T53_RS25085	COG3647	Membrane
E4T53_RS25090	COG2211	Major facilitator Superfamily
E4T53_RS25095	COG1486	melibiose metabolic process
E4T53_RS25100	COG2169	Transcriptional regulator
E4T53_RS25105	COG1982	Orn Lys Arg decarboxylase major
E4T53_RS25110	COG2207	Transcriptional regulator
E4T53_RS25115	COG0531	amino acid
E4T53_RS25120	COG2194	sulfuric ester hydrolase activity
E4T53_RS25125	COG0745	RESPONSE REGULATOR receiver
E4T53_RS25130	COG0642	Histidine kinase
E4T53_RS25140	COG0477	Major facilitator Superfamily
E4T53_RS25150	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4T53_RS25155	COG2824	Alkylphosphonate utilization operon protein PhnA
E4T53_RS25160	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4T53_RS25165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4T53_RS25170	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4T53_RS25175	COG3639	organic phosphonate transmembrane transporter activity
E4T53_RS25180	COG2188	Transcriptional regulator
E4T53_RS25185	COG3624	Phosphonate C-P lyase system protein PhnG
E4T53_RS25190	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E4T53_RS25195	COG3626	phosphonate metabolism
E4T53_RS25200	COG3627	carbon phosphorus lyase activity
E4T53_RS25205	COG4107	phosphonate C-P lyase system protein PhnK
E4T53_RS25210	COG4778	phosphonate C-P lyase system protein PhnL
E4T53_RS25215	COG3454	Phosphonate metabolism
E4T53_RS25220	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4T53_RS25225	COG0456	acetyltransferase
E4T53_RS25230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4T53_RS25245	COG1129	ABC transporter
E4T53_RS25250	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS25270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS25280	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4T53_RS25290	COG1566	PFAM secretion protein HlyD family protein
E4T53_RS25295	COG1289	transmembrane transporter activity
E4T53_RS25300	COG1538	Outer membrane efflux protein
E4T53_RS25310	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4T53_RS25315	COG1301	dicarboxylic acid transport
E4T53_RS25320	COG4235	cytochrome complex assembly
E4T53_RS25325	COG3088	subunit of a heme lyase
E4T53_RS25330	COG1138	Cytochrome C-type biogenesis protein
E4T53_RS25340	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS25345	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4T53_RS25355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T53_RS25360	COG3162	membrane
E4T53_RS25370	COG1357	PFAM Pentapeptide repeats (8 copies)
E4T53_RS25375	COG0025	NhaP-type Na H and K H
E4T53_RS25380	COG2252	PERMEase
E4T53_RS25385	COG0789	Transcriptional regulator
E4T53_RS25390	COG2207	Transcriptional regulator
E4T53_RS25395	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4T53_RS25405	COG0629	single-stranded DNA binding
E4T53_RS25410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4T53_RS25415	COG2315	Protein conserved in bacteria
E4T53_RS25420	COG0432	Pfam Uncharacterised protein family UPF0047
E4T53_RS25425	COG3700	Belongs to the class B bacterial acid phosphatase family
E4T53_RS25435	COG1448	Aminotransferase
E4T53_RS25440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4T53_RS25445	COG0305	Participates in initiation and elongation during chromosome replication
E4T53_RS25450	COG0604	alcohol dehydrogenase
E4T53_RS25460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T53_RS25500	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4T53_RS25520	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4T53_RS25560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T53_RS25570	COG0735	belongs to the Fur family
E4T53_RS25575	COG3237	CsbD-like
E4T53_RS25580	COG0534	Mate efflux family protein
E4T53_RS25590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4T53_RS25610	COG1357	PFAM Pentapeptide repeats (8 copies)
E4T53_RS25625	COG3842	ATPase activity
E4T53_RS25630	COG2182	Extracellular solute-binding protein
E4T53_RS25635	COG1175	transmembrane transport
E4T53_RS25640	COG3833	ABC-type maltose transport systems, permease component
E4T53_RS25645	COG0477	Major facilitator Superfamily
E4T53_RS25645	COG2814	Major facilitator Superfamily
E4T53_RS25665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T53_RS25690	COG0527	aspartate kinase activity
E4T53_RS25700	COG1187	pseudouridine synthase activity
E4T53_RS25745	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4T53_RS25750	COG0646	methionine synthase
E4T53_RS25750	COG1410	methionine synthase
E4T53_RS25755	COG1414	Transcriptional regulator
E4T53_RS25770	COG2224	Isocitrate lyase
E4T53_RS25775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4T53_RS25785	COG0456	acetyltransferase
E4T53_RS25815	COG0151	Belongs to the GarS family
E4T53_RS25820	COG2204	response regulator
E4T53_RS25825	COG4191	Histidine kinase
E4T53_RS25830	COG3678	ATP-independent chaperone mediated protein folding
E4T53_RS25845	COG3068	Protein conserved in bacteria
E4T53_RS25880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T53_RS25885	COG2104	thiamine diphosphate biosynthetic process
E4T53_RS25890	COG2022	thiamine diphosphate biosynthetic process
E4T53_RS25895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4T53_RS25935	COG0250	Participates in transcription elongation, termination and antitermination
E4T53_RS25940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4T53_RS25975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4T53_RS25975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4T53_RS25980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4T53_RS26005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4T53_RS26010	COG4206	TonB-dependent receptor
E4T53_RS26015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T53_RS26025	COG1309	transcriptional regulator
E4T53_RS26030	COG0477	Major facilitator Superfamily
E4T53_RS26035	COG1473	amidohydrolase
E4T53_RS26045	COG0583	DNA-binding transcription factor activity
E4T53_RS26060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4T53_RS26075	COG2194	sulfuric ester hydrolase activity
E4T53_RS26080	COG2207	Transcriptional regulator
E4T53_RS26085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS26090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4T53_RS26095	COG1882	Formate acetyltransferase
E4T53_RS26100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS26105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS26110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T53_RS26110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS26110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS26115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T53_RS26120	COG0371	Dehydrogenase
E4T53_RS26125	COG3738	Protein conserved in bacteria
E4T53_RS26130	COG0697	spore germination
E4T53_RS26140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4T53_RS26145	COG0460	homoserine dehydrogenase
E4T53_RS26145	COG0527	aspartate kinase activity
E4T53_RS26150	COG0626	cystathionine gamma-synthase activity
E4T53_RS26160	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E4T53_RS26175	COG3209	COG3209 Rhs family protein
E4T53_RS26185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4T53_RS26190	COG1609	Transcriptional regulator
E4T53_RS26195	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4T53_RS26210	COG1575	Belongs to the MenA family. Type 1 subfamily
E4T53_RS26235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4T53_RS26245	COG1494	fructose-1,6-bisphosphatase
E4T53_RS26255	COG0589	response to stress
E4T53_RS26260	COG3691	Protein conserved in bacteria
E4T53_RS26265	COG3152	Membrane
E4T53_RS26285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4T53_RS26340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4T53_RS26450	COG4695	Portal protein
E4T53_RS26500	COG4974	Belongs to the 'phage' integrase family
E4T53_RS26505	COG3678	ATP-independent chaperone mediated protein folding
E4T53_RS26510	COG0745	RESPONSE REGULATOR receiver
E4T53_RS26515	COG2205	protein histidine kinase activity
E4T53_RS26520	COG2258	MOSC domain
E4T53_RS26530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4T53_RS26540	COG4977	sequence-specific DNA binding
E4T53_RS26540	COG1917	Cupin 2, conserved barrel domain protein
E4T53_RS26575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS26580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS26580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T53_RS26585	COG1363	Peptidase, m42
E4T53_RS26590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T53_RS26590	COG3711	transcriptional antiterminator
E4T53_RS26610	COG0437	4 iron, 4 sulfur cluster binding
E4T53_RS26615	COG2864	formate dehydrogenase
E4T53_RS26625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4T53_RS26630	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4T53_RS26645	COG0456	acetyltransferase
E4T53_RS26660	COG1011	Hydrolase
E4T53_RS26665	COG1349	DNA-binding transcription factor activity
E4T53_RS26670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS26675	COG2084	Dehydrogenase
E4T53_RS26680	COG3684	Belongs to the aldolase LacD family
E4T53_RS26685	COG2942	2-epimerase
E4T53_RS26690	COG2017	converts alpha-aldose to the beta-anomer
E4T53_RS26700	COG1501	Belongs to the glycosyl hydrolase 31 family
E4T53_RS26705	COG2211	Major facilitator Superfamily
E4T53_RS26710	COG2211	Major facilitator Superfamily
E4T53_RS26715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4T53_RS26720	COG2271	Major facilitator Superfamily
E4T53_RS26725	COG1082	Xylose isomerase domain protein TIM barrel
E4T53_RS26730	COG2188	Transcriptional regulator
E4T53_RS26740	COG0174	glutamine synthetase
E4T53_RS26745	COG3852	Histidine kinase
E4T53_RS26750	COG2204	response regulator
E4T53_RS26760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T53_RS26765	COG3078	GTPase activator activity
E4T53_RS26775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4T53_RS26775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4T53_RS26780	COG0204	Acyl-transferase
E4T53_RS26785	COG5339	Protein conserved in bacteria
E4T53_RS26790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4T53_RS26795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4T53_RS26800	COG3084	Protein conserved in bacteria
E4T53_RS26805	COG0746	molybdenum cofactor guanylyltransferase activity
E4T53_RS26810	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4T53_RS26840	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4T53_RS26845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4T53_RS26850	COG1739	Uncharacterized protein family UPF0029
E4T53_RS26865	COG0183	Belongs to the thiolase family
E4T53_RS26870	COG0543	2 iron, 2 sulfur cluster binding
E4T53_RS26875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4T53_RS26880	COG0250	Participates in transcription elongation, termination and antitermination
E4T53_RS26885	COG0084	hydrolase, TatD family'
E4T53_RS26890	COG0805	protein transport
E4T53_RS26895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T53_RS26900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T53_RS26910	COG3165	ubiquinone biosynthetic process from chorismate
E4T53_RS26920	COG1322	Protein conserved in bacteria
E4T53_RS26925	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4T53_RS26930	COG0412	Dienelactone hydrolase
E4T53_RS26940	COG0583	DNA-binding transcription factor activity
E4T53_RS26945	COG0697	spore germination
E4T53_RS26950	COG0561	phosphatase activity
E4T53_RS26955	COG2267	carboxylic ester hydrolase activity
E4T53_RS26960	COG1280	lysine exporter protein (LysE YggA)
E4T53_RS26965	COG1280	lysine exporter protein (LysE YggA)
E4T53_RS26970	COG0514	ATP-dependent DNA helicase (RecQ)
E4T53_RS26975	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E4T53_RS26980	COG2050	protein possibly involved in aromatic compounds catabolism
E4T53_RS26985	COG2962	Rard protein
E4T53_RS27010	COG0598	Magnesium transport protein CorA
E4T53_RS27015	COG3698	Phosphodiester glycosidase
E4T53_RS27020	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4T53_RS27025	COG0210	DNA helicase
E4T53_RS27030	COG1011	Hydrolase
E4T53_RS27040	COG3159	Protein conserved in bacteria
E4T53_RS27050	COG5567	small periplasmic lipoprotein
E4T53_RS27060	COG3072	Adenylate cyclase
E4T53_RS27070	COG1587	Uroporphyrinogen-III synthase
E4T53_RS27075	COG2959	enzyme of heme biosynthesis
E4T53_RS27080	COG3071	HemY protein
E4T53_RS27085	COG3119	arylsulfatase activity
E4T53_RS27090	COG0641	radical SAM
E4T53_RS27120	COG1113	amino acid transport
E4T53_RS27140	COG2244	polysaccharide biosynthetic process
E4T53_RS27145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T53_RS27150	COG0456	acetyltransferase
E4T53_RS27155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4T53_RS27160	COG1088	dTDP-glucose 4,6-dehydratase activity
E4T53_RS27165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4T53_RS27170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4T53_RS27175	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4T53_RS27180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4T53_RS27185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4T53_RS27195	COG3118	belongs to the thioredoxin family
E4T53_RS27210	COG0210	DNA helicase
E4T53_RS27215	COG3692	DNA binding
E4T53_RS27220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T53_RS27230	COG0583	DNA-binding transcription factor activity
E4T53_RS27235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T53_RS27245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T53_RS27250	COG3978	acetolactate synthase activity
E4T53_RS27270	COG0606	chelatase, subunit chli
E4T53_RS27275	COG3085	chromosome segregation
E4T53_RS27315	COG2186	Transcriptional regulator
E4T53_RS27320	COG0477	Major facilitator Superfamily
E4T53_RS27325	COG1609	Transcriptional regulator
E4T53_RS27330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T53_RS27335	COG1879	ABC-type sugar transport system periplasmic component
E4T53_RS27340	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T53_RS27345	COG1129	ABC transporter
E4T53_RS27355	COG3158	transport of potassium into the cell
E4T53_RS27375	COG1522	sequence-specific DNA binding
E4T53_RS27380	COG0716	FMN binding
E4T53_RS27470	COG2274	protein secretion by the type I secretion system
E4T53_RS27490	COG4372	Transposase
E4T53_RS27495	COG3436	PFAM IS66 Orf2 family protein
E4T53_RS27655	COG1475	DNA binding
E4T53_RS27740	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4T53_RS27750	COG1525	nuclease
E4T53_RS27830	COG3468	outer membrane autotransporter barrel domain protein
E4T53_RS27840	COG0726	polysaccharide deacetylase
E4T53_RS27845	COG0297	glycogen (starch) synthase activity
E4T53_RS27850	COG2194	sulfuric ester hydrolase activity
E4T53_RS27855	COG1560	Kdo2-lipid A biosynthetic process