locus-tag	class	description
E4U69_RS00015	COG3312	ion transport
E4U69_RS00055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4U69_RS00065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4U69_RS00090	COG3539	Fimbrial protein
E4U69_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4U69_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E4U69_RS00110	COG0581	inorganic phosphate transmembrane transporter activity
E4U69_RS00115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4U69_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
E4U69_RS00145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U69_RS00150	COG2252	PERMEase
E4U69_RS00155	COG0431	NADPH-dependent FMN reductase
E4U69_RS00160	COG2091	lysine biosynthetic process via aminoadipic acid
E4U69_RS00175	COG0814	amino acid
E4U69_RS00230	COG0592	DNA-directed DNA polymerase activity
E4U69_RS00240	COG0187	DNA topoisomerase II activity
E4U69_RS00245	COG3753	Protein conserved in bacteria
E4U69_RS00250	COG0561	phosphatase activity
E4U69_RS00260	COG0644	oxidoreductase
E4U69_RS00265	COG0823	Involved in the tonB-independent uptake of proteins
E4U69_RS00270	COG5645	(Lipo)protein
E4U69_RS00290	COG2188	Transcriptional regulator
E4U69_RS00305	COG2207	Transcriptional regulator
E4U69_RS00310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4U69_RS00315	COG3119	arylsulfatase activity
E4U69_RS00325	COG2149	membrane
E4U69_RS00335	COG0641	radical SAM
E4U69_RS00340	COG2814	Major facilitator Superfamily
E4U69_RS00355	COG0028	Belongs to the TPP enzyme family
E4U69_RS00360	COG0440	acetolactate synthase activity
E4U69_RS00380	COG2197	response regulator
E4U69_RS00385	COG3851	Histidine kinase
E4U69_RS00390	COG2271	Major facilitator Superfamily
E4U69_RS00395	COG2271	Major facilitator Superfamily
E4U69_RS00425	COG2814	Major facilitator Superfamily
E4U69_RS00435	COG1464	Belongs to the NlpA lipoprotein family
E4U69_RS00440	COG0697	spore germination
E4U69_RS00445	COG2814	Major facilitator Superfamily
E4U69_RS00610	COG5492	domain, Protein
E4U69_RS00665	COG4372	Transposase
E4U69_RS00670	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS00715	COG0582	viral genome integration into host DNA
E4U69_RS00725	COG2211	Major facilitator Superfamily
E4U69_RS00730	COG1501	Belongs to the glycosyl hydrolase 31 family
E4U69_RS00735	COG2982	Protein involved in outer membrane biogenesis
E4U69_RS00740	COG2233	PERMEase
E4U69_RS00745	COG0786	glutamate:sodium symporter activity
E4U69_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4U69_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U69_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4U69_RS00775	COG0194	GDP metabolic process
E4U69_RS00785	COG2860	membrane
E4U69_RS00790	COG3645	SOS response
E4U69_RS00795	COG1561	YicC-like family, N-terminal region
E4U69_RS00820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4U69_RS00850	COG1519	Transferase
E4U69_RS00855	COG0859	PFAM glycosyl transferase family 9
E4U69_RS00860	COG0438	transferase activity, transferring glycosyl groups
E4U69_RS00865	COG0515	serine threonine protein kinase
E4U69_RS00875	COG3642	lipopolysaccharide core region biosynthetic process
E4U69_RS00895	COG0859	PFAM glycosyl transferase family 9
E4U69_RS00900	COG0859	PFAM glycosyl transferase family 9
E4U69_RS00915	COG0156	8-amino-7-oxononanoate synthase activity
E4U69_RS00925	COG1216	Glycosyl transferase, family 2
E4U69_RS00930	COG2861	carbohydrate metabolic process
E4U69_RS00935	COG4942	peptidase
E4U69_RS00945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U69_RS00950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U69_RS00965	COG1045	serine acetyltransferase
E4U69_RS00970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4U69_RS00980	COG2186	Transcriptional regulator
E4U69_RS00985	COG1620	l-lactate permease
E4U69_RS00990	COG5295	Hep Hag repeat protein
E4U69_RS01010	COG3722	fumarate hydratase activity
E4U69_RS01020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS01020	COG2213	PTS system mannitol-specific
E4U69_RS01030	COG1566	PFAM secretion protein HlyD family protein
E4U69_RS01040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U69_RS01045	COG3209	COG3209 Rhs family protein
E4U69_RS01050	COG0625	glutathione transferase activity
E4U69_RS01060	COG3276	selenocysteine insertion sequence binding
E4U69_RS01065	COG1454	alcohol dehydrogenase
E4U69_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS01085	COG1566	PFAM secretion protein HlyD family protein
E4U69_RS01090	COG0583	DNA-binding transcription factor activity
E4U69_RS01095	COG3713	MltA-interacting MipA family protein
E4U69_RS01105	COG2211	Major facilitator Superfamily
E4U69_RS01115	COG1414	Transcriptional regulator
E4U69_RS01120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS01125	COG3977	Valine--pyruvate aminotransferase
E4U69_RS01130	COG0366	Alpha amylase catalytic
E4U69_RS01135	COG2992	FlgJ-related protein
E4U69_RS01140	COG1609	Transcriptional regulator
E4U69_RS01140	COG2207	Transcriptional regulator
E4U69_RS01145	COG4214	carbohydrate transport
E4U69_RS01155	COG4213	ABC transporter substrate-binding protein
E4U69_RS01165	COG1070	Carbohydrate kinase
E4U69_RS01170	COG4682	membrane
E4U69_RS01175	COG4682	membrane
E4U69_RS01180	COG3274	enterobacterial common antigen metabolic process
E4U69_RS01205	COG1278	Cold shock
E4U69_RS01210	COG2944	sequence-specific DNA binding
E4U69_RS01225	COG2885	chlorophyll binding
E4U69_RS01230	COG0243	molybdopterin cofactor binding
E4U69_RS01235	COG0456	acetyltransferase
E4U69_RS01240	COG2818	Glycosylase
E4U69_RS01245	COG5571	outer membrane autotransporter
E4U69_RS01250	COG2223	nitrite transmembrane transporter activity
E4U69_RS01255	COG3539	Fimbrial protein
E4U69_RS01260	COG3121	Chaperone
E4U69_RS01270	COG3539	Fimbrial protein
E4U69_RS01275	COG3539	Fimbrial protein
E4U69_RS01280	COG2194	sulfuric ester hydrolase activity
E4U69_RS01290	COG0747	negative chemotaxis
E4U69_RS01295	COG0601	transmembrane transport
E4U69_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U69_RS01305	COG0444	Belongs to the ABC transporter superfamily
E4U69_RS01310	COG4608	Belongs to the ABC transporter superfamily
E4U69_RS01315	COG0814	amino acid
E4U69_RS01325	COG2194	sulfuric ester hydrolase activity
E4U69_RS01355	COG1215	transferase activity, transferring glycosyl groups
E4U69_RS01360	COG1215	transferase activity, transferring glycosyl groups
E4U69_RS01365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4U69_RS01375	COG2200	EAL domain
E4U69_RS01375	COG2199	diguanylate cyclase activity
E4U69_RS01385	COG0612	Peptidase, M16
E4U69_RS01395	COG2200	EAL domain
E4U69_RS01400	COG2982	Protein involved in outer membrane biogenesis
E4U69_RS01405	COG0477	Major facilitator Superfamily
E4U69_RS01410	COG1295	ribonuclease BN
E4U69_RS01415	COG0583	DNA-binding transcription factor activity
E4U69_RS01420	COG2197	response regulator
E4U69_RS01430	COG1858	cytochrome C peroxidase
E4U69_RS01435	COG0076	glutamate decarboxylase activity
E4U69_RS01440	COG2207	Transcriptional regulator
E4U69_RS01445	COG2207	Transcriptional regulator
E4U69_RS01450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U69_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS01465	COG2771	luxR family
E4U69_RS01470	COG3247	response to pH
E4U69_RS01485	COG1285	pathogenesis
E4U69_RS01490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4U69_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U69_RS01505	COG3721	Heme iron utilization protein
E4U69_RS01515	COG4558	Periplasmic binding protein
E4U69_RS01525	COG4771	TonB-dependent receptor
E4U69_RS01530	COG3720	iron ion transport
E4U69_RS01535	COG2197	response regulator
E4U69_RS01540	COG3065	identical protein binding
E4U69_RS01550	COG1393	Belongs to the ArsC family
E4U69_RS01555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4U69_RS01560	COG0640	Transcriptional regulator
E4U69_RS01570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U69_RS01575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4U69_RS01580	COG0339	signal peptide processing
E4U69_RS01590	COG3104	oligopeptide transport
E4U69_RS01595	COG0589	response to stress
E4U69_RS01605	COG0306	phosphate transporter
E4U69_RS01610	COG2081	HI0933 family
E4U69_RS01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS01635	COG1129	ABC transporter
E4U69_RS01635	COG0842	Transport permease protein
E4U69_RS01640	COG0842	Transport permease protein
E4U69_RS01655	COG0191	fructose-bisphosphate aldolase activity
E4U69_RS01670	COG3775	system Galactitol-specific IIC component
E4U69_RS01675	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U69_RS01685	COG2188	Transcriptional regulator
E4U69_RS01695	COG1124	(ABC) transporter
E4U69_RS01700	COG0444	Belongs to the ABC transporter superfamily
E4U69_RS01705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U69_RS01710	COG0601	transmembrane transport
E4U69_RS01715	COG0747	negative chemotaxis
E4U69_RS01720	COG2091	lysine biosynthetic process via aminoadipic acid
E4U69_RS01725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U69_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS01740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U69_RS01765	COG1216	Glycosyl transferase, family 2
E4U69_RS01785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4U69_RS01795	COG0204	Acyl-transferase
E4U69_RS01815	COG0628	permease
E4U69_RS01820	COG0477	Major facilitator Superfamily
E4U69_RS01830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4U69_RS01845	COG3714	YhhN family
E4U69_RS01855	COG3776	membrane
E4U69_RS01860	COG0742	ribosomal rna small subunit methyltransferase
E4U69_RS01865	COG0552	protein localization to endoplasmic reticulum
E4U69_RS01870	COG2884	Cell division ATP-binding protein ftsE
E4U69_RS01875	COG2177	Part of the ABC transporter FtsEX involved in
E4U69_RS01880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U69_RS01885	COG0683	leucine binding
E4U69_RS01900	COG0456	acetyltransferase
E4U69_RS01905	COG0683	leucine binding
E4U69_RS01910	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS01915	COG4177	L-phenylalanine transmembrane transporter activity
E4U69_RS01920	COG0411	ABC transporter
E4U69_RS01925	COG0410	ABC transporter
E4U69_RS01935	COG1653	transport
E4U69_RS01940	COG1175	transmembrane transport
E4U69_RS01950	COG3842	ATPase activity
E4U69_RS01955	COG0584	glycerophosphoryl diester phosphodiesterase
E4U69_RS01965	COG0405	Gamma-glutamyltransferase
E4U69_RS01975	COG1247	-acetyltransferase
E4U69_RS01980	COG0673	inositol 2-dehydrogenase activity
E4U69_RS01985	COG1741	Belongs to the pirin family
E4U69_RS01990	COG1609	Transcriptional regulator
E4U69_RS01995	COG3265	gluconokinase activity
E4U69_RS02000	COG2610	gluconate transmembrane transporter activity
E4U69_RS02005	COG0514	ATP-dependent DNA helicase (RecQ)
E4U69_RS02025	COG2095	MarC family integral membrane protein
E4U69_RS02030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4U69_RS02035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4U69_RS02055	COG0058	SHG alpha-glucan phosphorylase activity
E4U69_RS02060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4U69_RS02075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4U69_RS02090	COG1349	DNA-binding transcription factor activity
E4U69_RS02095	COG4650	regulator
E4U69_RS02100	COG1690	Belongs to the RtcB family
E4U69_RS02125	COG0058	SHG alpha-glucan phosphorylase activity
E4U69_RS02130	COG1640	4-alpha-glucanotransferase
E4U69_RS02135	COG2610	gluconate transmembrane transporter activity
E4U69_RS02145	COG1040	competence protein
E4U69_RS02155	COG5464	transposase or invertase
E4U69_RS02165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4U69_RS02170	COG1918	ferrous iron import across plasma membrane
E4U69_RS02175	COG2183	response to ionizing radiation
E4U69_RS02180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U69_RS02185	COG0745	RESPONSE REGULATOR receiver
E4U69_RS02190	COG2205	protein histidine kinase activity
E4U69_RS02200	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4U69_RS02210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4U69_RS02215	COG1011	Hydrolase
E4U69_RS02225	COG0494	nUDIX hydrolase
E4U69_RS02230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4U69_RS02235	COG4972	Pilus assembly protein
E4U69_RS02240	COG3166	PFAM Fimbrial assembly family protein
E4U69_RS02255	COG4796	Type ii and iii secretion system protein
E4U69_RS02270	COG3266	domain, Protein
E4U69_RS02275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4U69_RS02280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4U69_RS02285	COG0546	phosphoglycolate phosphatase activity
E4U69_RS02290	COG0180	Tryptophanyl-tRNA synthetase
E4U69_RS02295	COG2188	Transcriptional regulator
E4U69_RS02305	COG1082	Xylose isomerase domain protein TIM barrel
E4U69_RS02310	COG2222	sugar isomerase
E4U69_RS02315	COG0531	amino acid
E4U69_RS02330	COG2116	formate transmembrane transporter activity
E4U69_RS02335	COG2146	nitrite reductase [NAD(P)H] activity
E4U69_RS02340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4U69_RS02350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4U69_RS02360	COG2184	nucleotidyltransferase activity
E4U69_RS02365	COG0512	Glutamine amidotransferase of anthranilate synthase
E4U69_RS02370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4U69_RS02375	COG1289	transmembrane transporter activity
E4U69_RS02380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U69_RS02385	COG1765	OsmC-like protein
E4U69_RS02390	COG3954	Phosphoribulokinase
E4U69_RS02400	COG0429	hydrolase of the alpha beta-hydrolase fold
E4U69_RS02405	COG0488	(ABC) transporter
E4U69_RS02420	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4U69_RS02425	COG1047	Peptidyl-prolyl cis-trans
E4U69_RS02435	COG0545	Peptidyl-prolyl cis-trans isomerase
E4U69_RS02440	COG2964	Protein conserved in bacteria
E4U69_RS02510	COG0089	rRNA binding
E4U69_RS02600	COG0201	protein transport
E4U69_RS02640	COG0789	Transcriptional regulator
E4U69_RS02645	COG3036	rescue of stalled ribosome
E4U69_RS02655	COG0569	domain protein
E4U69_RS02675	COG0758	DNA mediated transformation
E4U69_RS02685	COG0551	DNA topoisomerase type I activity
E4U69_RS02690	COG0009	L-threonylcarbamoyladenylate synthase
E4U69_RS02705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4U69_RS02745	COG1126	abc transporter atp-binding protein
E4U69_RS02750	COG0765	amino acid transport
E4U69_RS02755	COG4597	amino acid ABC transporter
E4U69_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS02775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS02780	COG1309	transcriptional regulator
E4U69_RS02790	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4U69_RS02800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U69_RS02810	COG4145	pantothenate transmembrane transporter activity
E4U69_RS02815	COG3924	membrane
E4U69_RS02820	COG0439	Biotin carboxylase
E4U69_RS02825	COG0511	ligase activity, forming carbon-carbon bonds
E4U69_RS02830	COG0604	alcohol dehydrogenase
E4U69_RS02835	COG2199	diguanylate cyclase activity
E4U69_RS02835	COG2200	EAL domain
E4U69_RS02840	COG1077	Cell shape determining protein MreB Mrl
E4U69_RS02845	COG1792	Involved in formation and maintenance of cell shape
E4U69_RS02850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4U69_RS02855	COG0424	maF-like protein
E4U69_RS02860	COG1530	ribonuclease E activity
E4U69_RS02865	COG3164	Protein of unknown function
E4U69_RS02870	COG0312	modulator of DNA gyrase
E4U69_RS02875	COG0583	DNA-binding transcription factor activity
E4U69_RS02895	COG2732	(Barnase) inhibitor
E4U69_RS02915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U69_RS02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U69_RS02925	COG3105	Protein conserved in bacteria
E4U69_RS02930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4U69_RS02945	COG0625	glutathione transferase activity
E4U69_RS02950	COG2969	positive regulation of protein catabolic process
E4U69_RS02955	COG3069	C4-dicarboxylate transmembrane transporter activity
E4U69_RS02985	COG2731	YhcH YjgK YiaL family protein
E4U69_RS02990	COG4804	nuclease activity
E4U69_RS02995	COG0493	'glutamate synthase
E4U69_RS03000	COG0070	glutamate synthase
E4U69_RS03000	COG0069	glutamate synthase activity
E4U69_RS03000	COG0067	glutamate synthase
E4U69_RS03005	COG1242	4 iron, 4 sulfur cluster binding
E4U69_RS03010	COG0784	Response regulator, receiver
E4U69_RS03010	COG2198	Histidine kinase
E4U69_RS03010	COG5002	protein histidine kinase activity
E4U69_RS03015	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4U69_RS03025	COG0515	serine threonine protein kinase
E4U69_RS03030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS03045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4U69_RS03050	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4U69_RS03055	COG1137	ATPase activity
E4U69_RS03060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4U69_RS03065	COG3117	lipopolysaccharide transmembrane transporter activity
E4U69_RS03070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4U69_RS03075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4U69_RS03075	COG0517	IMP dehydrogenase activity
E4U69_RS03080	COG0530	calcium, potassium:sodium antiporter activity
E4U69_RS03085	COG1127	ABC transporter
E4U69_RS03090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4U69_RS03095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4U69_RS03100	COG2854	intermembrane phospholipid transfer
E4U69_RS03105	COG3113	response to antibiotic
E4U69_RS03110	COG5007	Belongs to the BolA IbaG family
E4U69_RS03120	COG3423	Transcriptional regulator
E4U69_RS03125	COG0142	geranyltranstransferase activity
E4U69_RS03140	COG0697	spore germination
E4U69_RS03150	COG2027	D-alanyl-D-alanine carboxypeptidase
E4U69_RS03155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U69_RS03160	COG1534	Rna-binding protein
E4U69_RS03170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4U69_RS03175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4U69_RS03185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4U69_RS03195	COG2194	sulfuric ester hydrolase activity
E4U69_RS03215	COG0195	Participates in both transcription termination and antitermination
E4U69_RS03255	COG0513	Belongs to the DEAD box helicase family
E4U69_RS03260	COG0814	amino acid
E4U69_RS03265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4U69_RS03270	COG0826	peptidase U32
E4U69_RS03275	COG0826	peptidase U32
E4U69_RS03280	COG3154	lipid carrier protein
E4U69_RS03285	COG3153	acetyltransferase
E4U69_RS03295	COG3787	Belongs to the UPF0306 family
E4U69_RS03300	COG0693	protein deglycase activity
E4U69_RS03305	COG0702	epimerase
E4U69_RS03310	COG0701	Predicted permease
E4U69_RS03315	COG2823	Periplasmic or secreted lipoprotein
E4U69_RS03335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4U69_RS03355	COG3188	usher protein
E4U69_RS03360	COG3121	Chaperone
E4U69_RS03365	COG3539	Fimbrial protein
E4U69_RS03375	COG3716	PTS system mannose fructose sorbose family IID component
E4U69_RS03385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS03395	COG2222	sugar isomerase
E4U69_RS03400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U69_RS03405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS03410	COG3716	PTS system mannose fructose sorbose family IID component
E4U69_RS03420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS03430	COG1349	DNA-binding transcription factor activity
E4U69_RS03440	COG2002	toxin-antitoxin pair type II binding
E4U69_RS03445	COG2721	sulfolactate sulfo-lyase activity
E4U69_RS03450	COG2271	Major facilitator Superfamily
E4U69_RS03460	COG2084	Dehydrogenase
E4U69_RS03465	COG1929	Belongs to the glycerate kinase type-1 family
E4U69_RS03490	COG0583	DNA-binding transcription factor activity
E4U69_RS03495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U69_RS03505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4U69_RS03510	COG1882	Formate acetyltransferase
E4U69_RS03515	COG0251	oxidation-reduction process
E4U69_RS03520	COG1760	l-serine dehydratase
E4U69_RS03525	COG0814	amino acid
E4U69_RS03540	COG1741	Belongs to the pirin family
E4U69_RS03545	COG0583	DNA-binding transcription factor activity
E4U69_RS03550	COG3152	Membrane
E4U69_RS03555	COG3152	Membrane
E4U69_RS03560	COG0435	Glutathione S-transferase
E4U69_RS03565	COG2259	Doxx family
E4U69_RS03575	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E4U69_RS03580	COG4575	ribosome binding
E4U69_RS03585	COG1422	Protein of unknown function (DUF1090)
E4U69_RS03595	COG0586	Pfam SNARE associated Golgi protein
E4U69_RS03600	COG2186	Transcriptional regulator
E4U69_RS03605	COG2271	Major facilitator Superfamily
E4U69_RS03615	COG2721	sulfolactate sulfo-lyase activity
E4U69_RS03625	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4U69_RS03630	COG0861	Integral membrane protein TerC family
E4U69_RS03635	COG0673	inositol 2-dehydrogenase activity
E4U69_RS03640	COG2949	membrane
E4U69_RS03645	COG1451	nucleotide metabolic process
E4U69_RS03655	COG4680	protein conserved in bacteria
E4U69_RS03660	COG5499	transcription regulator containing HTH domain
E4U69_RS03665	COG1902	pentaerythritol trinitrate reductase activity
E4U69_RS03665	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4U69_RS03670	COG3408	Glycogen debranching enzyme
E4U69_RS03670	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4U69_RS03680	COG0531	amino acid
E4U69_RS03685	COG2731	YhcH YjgK YiaL family protein
E4U69_RS03690	COG3250	beta-galactosidase activity
E4U69_RS03695	COG1609	Transcriptional regulator
E4U69_RS03700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4U69_RS03710	COG0840	transmembrane signaling receptor activity
E4U69_RS03715	COG1695	Transcriptional regulator
E4U69_RS03720	COG2375	cellular response to nickel ion
E4U69_RS03735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U69_RS03740	COG0358	DNA primase activity
E4U69_RS03745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4U69_RS03750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4U69_RS03755	COG0471	metal ion transport
E4U69_RS03760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS03765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS03770	COG0583	DNA-binding transcription factor activity
E4U69_RS03780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4U69_RS03795	COG4991	sh3 domain protein
E4U69_RS03800	COG3025	triphosphatase activity
E4U69_RS03825	COG2268	Band 7 protein
E4U69_RS03830	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4U69_RS03860	COG3384	dioxygenase
E4U69_RS03865	COG0754	glutathionylspermidine amidase activity
E4U69_RS03875	COG1538	Outer membrane efflux protein
E4U69_RS03880	COG0494	nUDIX hydrolase
E4U69_RS03885	COG3151	Protein conserved in bacteria
E4U69_RS03890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4U69_RS03895	COG3150	esterase
E4U69_RS03900	COG0187	DNA topoisomerase II activity
E4U69_RS03905	COG4774	siderophore transport
E4U69_RS03910	COG1120	ATPase activity
E4U69_RS03915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U69_RS03920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U69_RS03930	COG1737	Transcriptional regulator
E4U69_RS03935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4U69_RS03940	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4U69_RS03945	COG0642	Histidine kinase
E4U69_RS03950	COG0745	RESPONSE REGULATOR receiver
E4U69_RS03955	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U69_RS03960	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4U69_RS03965	COG4166	transmembrane transport
E4U69_RS03970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4U69_RS03975	COG0204	Acyl-transferase
E4U69_RS03980	COG2132	Multicopper oxidase
E4U69_RS03985	COG1032	radical SAM domain protein
E4U69_RS03990	COG4238	major outer membrane lipoprotein
E4U69_RS04000	COG0656	L-ascorbic acid biosynthetic process
E4U69_RS04005	COG1979	alcohol dehydrogenase
E4U69_RS04010	COG2207	Transcriptional regulator
E4U69_RS04015	COG0586	Pfam SNARE associated Golgi protein
E4U69_RS04020	COG0626	cystathionine gamma-synthase activity
E4U69_RS04025	COG0811	peptide transport
E4U69_RS04030	COG0848	biopolymer transport protein
E4U69_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS04045	COG0667	Aldo Keto reductase
E4U69_RS04060	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4U69_RS04065	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS04070	COG5557	Pfam Polysulphide reductase, NrfD
E4U69_RS04075	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4U69_RS04080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U69_RS04085	COG1773	rubredoxin
E4U69_RS04090	COG0375	protein maturation
E4U69_RS04095	COG0298	carbon dioxide binding
E4U69_RS04100	COG0625	glutathione transferase activity
E4U69_RS04105	COG0754	glutathionylspermidine amidase activity
E4U69_RS04130	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS04135	COG4372	Transposase
E4U69_RS04140	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS04210	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS04225	COG0582	viral genome integration into host DNA
E4U69_RS04235	COG1811	Na channel or pump
E4U69_RS04240	COG1982	Orn Lys Arg decarboxylase major
E4U69_RS04245	COG2211	Major facilitator Superfamily
E4U69_RS04260	COG1194	a g-specific adenine glycosylase
E4U69_RS04270	COG3171	Protein conserved in bacteria
E4U69_RS04280	COG0252	asparaginase activity
E4U69_RS04290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4U69_RS04295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4U69_RS04305	COG0762	integral membrane protein
E4U69_RS04310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4U69_RS04315	COG2805	Type II/IV secretion system protein
E4U69_RS04330	COG0189	ligase activity
E4U69_RS04335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4U69_RS04340	COG2356	endonuclease I
E4U69_RS04345	COG3091	SprT-like family
E4U69_RS04350	COG2814	Major facilitator Superfamily
E4U69_RS04370	COG1166	arginine decarboxylase activity
E4U69_RS04385	COG0501	Belongs to the peptidase M48B family
E4U69_RS04390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4U69_RS04395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS04400	COG2213	PTS system mannitol-specific
E4U69_RS04405	COG1063	alcohol dehydrogenase
E4U69_RS04410	COG1494	fructose-1,6-bisphosphatase
E4U69_RS04420	COG1072	(Pantothenic acid kinase))
E4U69_RS04425	COG1122	ATPase activity
E4U69_RS04430	COG1122	ATPase activity
E4U69_RS04455	COG0126	phosphoglycerate kinase activity
E4U69_RS04460	COG0191	fructose-bisphosphate aldolase activity
E4U69_RS04465	COG0668	transmembrane transport
E4U69_RS04475	COG2968	Membrane
E4U69_RS04485	COG0427	acetyl-CoA hydrolase
E4U69_RS04490	COG1024	Enoyl-CoA hydratase
E4U69_RS04495	COG1703	isobutyryl-CoA mutase activity
E4U69_RS04500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U69_RS04500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U69_RS04515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4U69_RS04530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4U69_RS04550	COG0006	proline dipeptidase activity
E4U69_RS04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U69_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U69_RS04585	COG2723	6-phospho-beta-galactosidase activity
E4U69_RS04595	COG1272	protein, Hemolysin III
E4U69_RS04605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4U69_RS04615	COG0716	FMN binding
E4U69_RS04620	COG4974	Belongs to the 'phage' integrase family
E4U69_RS04625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U69_RS04630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4U69_RS04640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4U69_RS04660	COG2233	PERMEase
E4U69_RS04675	COG2252	PERMEase
E4U69_RS04680	COG0402	S-adenosylhomocysteine deaminase activity
E4U69_RS04685	COG2233	PERMEase
E4U69_RS04690	COG2080	2 iron, 2 sulfur cluster binding
E4U69_RS04690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U69_RS04695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U69_RS04700	COG0402	S-adenosylhomocysteine deaminase activity
E4U69_RS04705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS04705	COG0493	'glutamate synthase
E4U69_RS04710	COG2068	MobA-Related Protein
E4U69_RS04715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4U69_RS04720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4U69_RS04720	COG3608	succinylglutamate desuccinylase aspartoacylase
E4U69_RS04725	COG0549	Belongs to the carbamate kinase family
E4U69_RS04735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4U69_RS04740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U69_RS04745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4U69_RS04755	COG2080	2 iron, 2 sulfur cluster binding
E4U69_RS04760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U69_RS04765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U69_RS04770	COG4942	peptidase
E4U69_RS04790	COG2207	Transcriptional regulator
E4U69_RS04895	COG2197	response regulator
E4U69_RS04900	COG0741	lytic transglycosylase activity
E4U69_RS04910	COG0457	Tetratricopeptide repeat
E4U69_RS04910	COG3710	Transcriptional regulator
E4U69_RS04920	COG0457	Tetratricopeptide repeat
E4U69_RS04945	COG3710	Transcriptional regulator
E4U69_RS04950	COG2771	luxR family
E4U69_RS04955	COG0814	amino acid
E4U69_RS04960	COG0183	Belongs to the thiolase family
E4U69_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS04975	COG2814	Major facilitator Superfamily
E4U69_RS04980	COG1794	racemase activity, acting on amino acids and derivatives
E4U69_RS04985	COG0583	DNA-binding transcription factor activity
E4U69_RS04995	COG1609	Transcriptional regulator
E4U69_RS05010	COG0667	Aldo Keto reductase
E4U69_RS05020	COG0861	Integral membrane protein TerC family
E4U69_RS05035	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E4U69_RS05050	COG2165	general secretion pathway protein
E4U69_RS05055	COG4795	General secretion pathway protein
E4U69_RS05065	COG4967	type IV pilus modification protein PilV
E4U69_RS05070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4U69_RS05075	COG1025	Belongs to the peptidase M16 family
E4U69_RS05080	COG1074	ATP-dependent DNA helicase activity
E4U69_RS05085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4U69_RS05090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4U69_RS05090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4U69_RS05095	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U69_RS05115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4U69_RS05120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4U69_RS05125	COG2166	iron-sulfur cluster assembly
E4U69_RS05130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4U69_RS05140	COG0583	DNA-binding transcription factor activity
E4U69_RS05145	COG2363	Small membrane protein
E4U69_RS05155	COG1349	DNA-binding transcription factor activity
E4U69_RS05165	COG1070	Carbohydrate kinase
E4U69_RS05175	COG0738	Major facilitator superfamily
E4U69_RS05180	COG0235	Class ii aldolase
E4U69_RS05185	COG1454	alcohol dehydrogenase
E4U69_RS05195	COG1760	l-serine dehydratase
E4U69_RS05200	COG0814	amino acid
E4U69_RS05205	COG1611	Belongs to the LOG family
E4U69_RS05220	COG3098	single-species biofilm formation
E4U69_RS05225	COG0564	pseudouridine synthase activity
E4U69_RS05230	COG0716	FMN binding
E4U69_RS05235	COG2271	Major facilitator Superfamily
E4U69_RS05245	COG4948	Mandelate Racemase Muconate Lactonizing
E4U69_RS05250	COG3437	response regulator, receiver
E4U69_RS05250	COG3850	Histidine kinase
E4U69_RS05250	COG4999	Histidine kinase
E4U69_RS05250	COG2205	protein histidine kinase activity
E4U69_RS05255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4U69_RS05260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4U69_RS05265	COG2336	PFAM SpoVT AbrB
E4U69_RS05270	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4U69_RS05275	COG3956	TIGRFAM MazG family protein
E4U69_RS05290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4U69_RS05300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4U69_RS05310	COG0602	queuosine metabolic process
E4U69_RS05315	COG1070	Carbohydrate kinase
E4U69_RS05320	COG2223	nitrite transmembrane transporter activity
E4U69_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS05330	COG0277	FAD linked oxidase domain protein
E4U69_RS05340	COG2086	electron transfer activity
E4U69_RS05350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4U69_RS05355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U69_RS05360	COG0644	oxidoreductase
E4U69_RS05365	COG0720	synthase
E4U69_RS05370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4U69_RS05390	COG1203	CRISPR-associated helicase, Cas3
E4U69_RS05405	COG1857	crispr-associated protein
E4U69_RS05420	COG1518	maintenance of DNA repeat elements
E4U69_RS05425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS05430	COG2234	aminopeptidase activity
E4U69_RS05485	COG1388	LysM domain
E4U69_RS05485	COG4942	peptidase
E4U69_RS05490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U69_RS05495	COG1846	Transcriptional regulator
E4U69_RS05505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4U69_RS05515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4U69_RS05535	COG3604	Transcriptional regulator
E4U69_RS05540	COG0309	Hydrogenase expression formation protein (HypE)
E4U69_RS05545	COG0409	Hydrogenase expression formation protein
E4U69_RS05550	COG0298	carbon dioxide binding
E4U69_RS05555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4U69_RS05560	COG0375	protein maturation
E4U69_RS05570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS05575	COG0651	ATP synthesis coupled electron transport
E4U69_RS05580	COG0650	Formate hydrogenlyase subunit 4
E4U69_RS05585	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4U69_RS05585	COG3261	NADH dehydrogenase
E4U69_RS05590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U69_RS05595	COG3260	NADH ubiquinone oxidoreductase 20
E4U69_RS05605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U69_RS05610	COG2723	6-phospho-beta-galactosidase activity
E4U69_RS05615	COG1263	PTS System
E4U69_RS05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS05620	COG1609	Transcriptional regulator
E4U69_RS05625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS05630	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4U69_RS05650	COG0517	IMP dehydrogenase activity
E4U69_RS05650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4U69_RS05655	COG1349	DNA-binding transcription factor activity
E4U69_RS05660	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS05685	COG2951	lytic endotransglycosylase activity
E4U69_RS05690	COG1546	Belongs to the CinA family
E4U69_RS05705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4U69_RS05710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4U69_RS05740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U69_RS05745	COG1238	metal cluster binding
E4U69_RS05760	COG2814	Major facilitator Superfamily
E4U69_RS05765	COG1566	PFAM secretion protein HlyD family protein
E4U69_RS05770	COG1846	Transcriptional regulator
E4U69_RS05780	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4U69_RS05785	COG2814	Major facilitator Superfamily
E4U69_RS05790	COG2113	Glycine betaine
E4U69_RS05795	COG4176	ABC-type proline glycine betaine transport system permease component
E4U69_RS05800	COG4175	Glycine betaine
E4U69_RS05805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U69_RS05810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U69_RS05820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U69_RS05825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U69_RS05835	COG4575	ribosome binding
E4U69_RS05850	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4U69_RS05855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U69_RS05860	COG0640	Transcriptional regulator
E4U69_RS05865	COG0401	homolog of Blt101
E4U69_RS05870	COG1652	LysM domain
E4U69_RS05875	COG1802	Transcriptional regulator
E4U69_RS05880	COG1113	amino acid transport
E4U69_RS05885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4U69_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS05895	COG0579	oxidoreductase
E4U69_RS05930	COG3468	outer membrane autotransporter barrel domain protein
E4U69_RS05985	COG2826	transposase and inactivated derivatives, IS30 family
E4U69_RS06045	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS06110	COG2867	negative regulation of translational initiation
E4U69_RS06120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U69_RS06125	COG0497	DNA recombination
E4U69_RS06140	COG4536	flavin adenine dinucleotide binding
E4U69_RS06145	COG4137	Cytochrome C assembly protein
E4U69_RS06150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4U69_RS06175	COG2885	chlorophyll binding
E4U69_RS06180	COG2199	diguanylate cyclase activity
E4U69_RS06195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U69_RS06200	COG1605	Chorismate mutase
E4U69_RS06200	COG0287	Prephenate dehydrogenase
E4U69_RS06205	COG1605	Chorismate mutase
E4U69_RS06205	COG0077	Prephenate dehydratase
E4U69_RS06215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4U69_RS06220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U69_RS06225	COG0564	pseudouridine synthase activity
E4U69_RS06235	COG0542	response to heat
E4U69_RS06260	COG0477	Major facilitator Superfamily
E4U69_RS06265	COG5544	Lipoprotein
E4U69_RS06270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U69_RS06275	COG1042	CoA-binding domain protein
E4U69_RS06275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U69_RS06275	COG0045	succinate-CoA ligase (ADP-forming) activity
E4U69_RS06285	COG3118	belongs to the thioredoxin family
E4U69_RS06290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U69_RS06305	COG1280	lysine exporter protein (LysE YggA)
E4U69_RS06310	COG0583	DNA-binding transcription factor activity
E4U69_RS06315	COG0513	Belongs to the DEAD box helicase family
E4U69_RS06320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4U69_RS06325	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4U69_RS06335	COG1595	DNA-templated transcription, initiation
E4U69_RS06340	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4U69_RS06345	COG3026	antisigma factor binding
E4U69_RS06350	COG3086	response to oxidative stress
E4U69_RS06360	COG0681	Belongs to the peptidase S26 family
E4U69_RS06380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4U69_RS06395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS06400	COG1737	Transcriptional regulator
E4U69_RS06405	COG0560	Phosphoserine phosphatase
E4U69_RS06410	COG0590	tRNA wobble adenosine to inosine editing
E4U69_RS06415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4U69_RS06420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4U69_RS06420	COG0047	phosphoribosylformylglycinamidine synthase activity
E4U69_RS06425	COG2205	protein histidine kinase activity
E4U69_RS06430	COG3170	Tfp pilus assembly protein FimV
E4U69_RS06435	COG2204	response regulator
E4U69_RS06440	COG0347	Belongs to the P(II) protein family
E4U69_RS06445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U69_RS06445	COG1017	nitric oxide dioxygenase activity
E4U69_RS06455	COG1940	carbohydrate kinase activity
E4U69_RS06460	COG0457	Tetratricopeptide repeat
E4U69_RS06465	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS06470	COG1129	ABC transporter
E4U69_RS06475	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS06480	COG1063	alcohol dehydrogenase
E4U69_RS06485	COG1063	alcohol dehydrogenase
E4U69_RS06490	COG2017	converts alpha-aldose to the beta-anomer
E4U69_RS06495	COG2259	Doxx family
E4U69_RS06520	COG4638	Rieske (2fe-2S)
E4U69_RS06525	COG0583	DNA-binding transcription factor activity
E4U69_RS06530	COG2814	Major facilitator Superfamily
E4U69_RS06535	COG3711	transcriptional antiterminator
E4U69_RS06540	COG1073	alpha beta
E4U69_RS06545	COG0483	inositol monophosphate 1-phosphatase activity
E4U69_RS06565	COG0822	iron-sulfur transferase activity
E4U69_RS06585	COG0633	Ferredoxin
E4U69_RS06590	COG2975	iron-sulfur cluster assembly
E4U69_RS06605	COG2897	thiosulfate sulfurtransferase activity
E4U69_RS06610	COG2373	Large extracellular alpha-helical protein
E4U69_RS06615	COG4953	penicillin-binding protein 1C
E4U69_RS06620	COG0243	molybdopterin cofactor binding
E4U69_RS06625	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS06630	COG3302	dmso reductase anchor subunit
E4U69_RS06665	COG2976	Protein conserved in bacteria
E4U69_RS06680	COG1645	bacterial-type flagellum-dependent swarming motility
E4U69_RS06690	COG0516	GMP reductase activity
E4U69_RS06690	COG0517	IMP dehydrogenase activity
E4U69_RS06705	COG3133	Outer membrane lipoprotein
E4U69_RS06720	COG2200	EAL domain
E4U69_RS06725	COG0248	Ppx GppA phosphatase
E4U69_RS06730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4U69_RS06735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4U69_RS06750	COG2233	PERMEase
E4U69_RS06760	COG1393	Belongs to the ArsC family
E4U69_RS06765	COG4783	chaperone-mediated protein folding
E4U69_RS06770	COG0628	permease
E4U69_RS06775	COG2116	formate transmembrane transporter activity
E4U69_RS06780	COG3604	Transcriptional regulator
E4U69_RS06790	COG3260	NADH ubiquinone oxidoreductase 20
E4U69_RS06795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U69_RS06800	COG3261	NADH dehydrogenase
E4U69_RS06800	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4U69_RS06805	COG0651	ATP synthesis coupled electron transport
E4U69_RS06810	COG4237	Hydrogenase 4 membrane
E4U69_RS06815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4U69_RS06820	COG0650	Formate hydrogenlyase subunit 4
E4U69_RS06825	COG0651	ATP synthesis coupled electron transport
E4U69_RS06830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS06835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4U69_RS06840	COG2716	regulation of RNA biosynthetic process
E4U69_RS06850	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4U69_RS06860	COG2321	neutral zinc metallopeptidase
E4U69_RS06870	COG0400	carboxylic ester hydrolase activity
E4U69_RS06885	COG1393	Belongs to the ArsC family
E4U69_RS06895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U69_RS06900	COG3850	Histidine kinase
E4U69_RS06905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS06905	COG0493	'glutamate synthase
E4U69_RS06915	COG5342	invasion associated locus B
E4U69_RS06920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4U69_RS06925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U69_RS06930	COG0280	phosphate acetyltransferase
E4U69_RS06930	COG0281	malic enzyme
E4U69_RS06935	COG4810	utilization protein
E4U69_RS06945	COG4766	ethanolamine catabolic process
E4U69_RS06950	COG4812	Cobalamin adenosyltransferase
E4U69_RS06955	COG0280	phosphate acetyltransferase
E4U69_RS06960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4U69_RS06965	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E4U69_RS06970	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS06975	COG4820	ethanolamine utilization protein (EutJ)
E4U69_RS06980	COG1454	alcohol dehydrogenase
E4U69_RS06985	COG3192	ethanolamine utilization protein
E4U69_RS06990	COG4819	ethanolamine utilization protein
E4U69_RS06995	COG4303	Ethanolamine ammonia lyase large subunit
E4U69_RS07005	COG4816	utilization protein
E4U69_RS07010	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4U69_RS07015	COG2207	Transcriptional regulator
E4U69_RS07025	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U69_RS07045	COG2837	iron assimilation
E4U69_RS07050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U69_RS07055	COG1263	PTS System
E4U69_RS07055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS07070	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS07075	COG4150	thiosulfate binding
E4U69_RS07080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4U69_RS07085	COG4208	sulfate ABC transporter
E4U69_RS07090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4U69_RS07095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4U69_RS07110	COG2190	(PTS) system
E4U69_RS07115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U69_RS07120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS07125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4U69_RS07145	COG3530	Putative quorum-sensing-regulated virulence factor
E4U69_RS07150	COG0385	Bile acid
E4U69_RS07195	COG0675	Transposase, IS605 OrfB family
E4U69_RS07200	COG3415	Transposase
E4U69_RS07205	COG3415	Transposase
E4U69_RS07220	COG2199	diguanylate cyclase activity
E4U69_RS07220	COG2200	EAL domain
E4U69_RS07225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U69_RS07250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS07255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS07260	COG0006	proline dipeptidase activity
E4U69_RS07265	COG1363	Peptidase, m42
E4U69_RS07270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS07270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U69_RS07270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS07275	COG2207	Transcriptional regulator
E4U69_RS07280	COG3279	Response regulator of the LytR AlgR family
E4U69_RS07285	COG3275	phosphorelay sensor kinase activity
E4U69_RS07290	COG0436	Aminotransferase
E4U69_RS07300	COG1560	Kdo2-lipid A biosynthetic process
E4U69_RS07325	COG0028	Belongs to the TPP enzyme family
E4U69_RS07330	COG0679	Auxin Efflux Carrier
E4U69_RS07340	COG2205	protein histidine kinase activity
E4U69_RS07340	COG0784	Response regulator, receiver
E4U69_RS07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS07340	COG2198	Histidine kinase
E4U69_RS07345	COG2197	response regulator
E4U69_RS07350	COG1566	PFAM secretion protein HlyD family protein
E4U69_RS07355	COG0477	Major facilitator Superfamily
E4U69_RS07430	COG0582	viral genome integration into host DNA
E4U69_RS07440	COG2116	formate transmembrane transporter activity
E4U69_RS07445	COG2853	Lipoprotein
E4U69_RS07455	COG2067	long-chain fatty acid transport protein
E4U69_RS07460	COG3691	Protein conserved in bacteria
E4U69_RS07470	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4U69_RS07470	COG1024	Enoyl-CoA hydratase
E4U69_RS07475	COG2062	phosphohistidine phosphatase, SixA
E4U69_RS07480	COG3539	Fimbrial protein
E4U69_RS07485	COG3188	usher protein
E4U69_RS07490	COG3121	Chaperone
E4U69_RS07495	COG3539	Fimbrial protein
E4U69_RS07500	COG3539	Fimbrial protein
E4U69_RS07505	COG3539	Fimbrial protein
E4U69_RS07515	COG3539	Fimbrial protein
E4U69_RS07545	COG0730	response to heat
E4U69_RS07550	COG3101	peptidyl-lysine hydroxylation
E4U69_RS07560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4U69_RS07560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4U69_RS07565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U69_RS07570	COG2814	Major facilitator Superfamily
E4U69_RS07585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4U69_RS07595	COG0586	Pfam SNARE associated Golgi protein
E4U69_RS07605	COG0285	dihydrofolate synthase activity
E4U69_RS07610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4U69_RS07615	COG1286	toxin biosynthetic process
E4U69_RS07620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4U69_RS07625	COG0163	prenyltransferase activity
E4U69_RS07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS07640	COG4215	(ABC) transporter
E4U69_RS07645	COG4160	amino acid transport
E4U69_RS07650	COG4598	ABC transporter
E4U69_RS07655	COG5464	transposase or invertase
E4U69_RS07660	COG1090	epimerase
E4U69_RS07665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4U69_RS07670	COG0625	glutathione transferase activity
E4U69_RS07675	COG0625	glutathione transferase activity
E4U69_RS07680	COG0622	Phosphoesterase
E4U69_RS07685	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4U69_RS07690	COG1288	antiporter activity
E4U69_RS07695	COG0857	belongs to the CobB CobQ family
E4U69_RS07695	COG0280	phosphate acetyltransferase
E4U69_RS07700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4U69_RS07715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U69_RS07720	COG0490	domain, Protein
E4U69_RS07720	COG0471	metal ion transport
E4U69_RS07730	COG0436	Aminotransferase
E4U69_RS07735	COG0583	DNA-binding transcription factor activity
E4U69_RS07755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4U69_RS07760	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4U69_RS07765	COG1034	ATP synthesis coupled electron transport
E4U69_RS07780	COG0839	Belongs to the complex I subunit 6 family
E4U69_RS07790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4U69_RS07795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U69_RS07820	COG5160	protein modification by small protein removal
E4U69_RS07825	COG1234	tRNA 3'-trailer cleavage
E4U69_RS07830	COG2153	protein acetylation
E4U69_RS07835	COG4575	ribosome binding
E4U69_RS07840	COG1169	isochorismate synthase
E4U69_RS07855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4U69_RS07865	COG0318	PFAM AMP-dependent synthetase and ligase
E4U69_RS07910	COG0406	alpha-ribazole phosphatase activity
E4U69_RS07930	COG1414	Transcriptional regulator
E4U69_RS07935	COG4948	Mandelate Racemase Muconate Lactonizing
E4U69_RS07940	COG2271	Major facilitator Superfamily
E4U69_RS07955	COG3836	Belongs to the HpcH HpaI aldolase family
E4U69_RS07960	COG5464	transposase or invertase
E4U69_RS07965	COG0247	lactate metabolic process
E4U69_RS07975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4U69_RS07980	COG2271	Major facilitator Superfamily
E4U69_RS07985	COG0584	glycerophosphoryl diester phosphodiesterase
E4U69_RS07995	COG0583	DNA-binding transcription factor activity
E4U69_RS08000	COG2814	Major facilitator Superfamily
E4U69_RS08005	COG3642	lipopolysaccharide core region biosynthetic process
E4U69_RS08010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U69_RS08015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U69_RS08020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U69_RS08025	COG3468	outer membrane autotransporter barrel domain protein
E4U69_RS08035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4U69_RS08040	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E4U69_RS08045	COG3234	Protein of unknown function (DUF1175)
E4U69_RS08050	COG2373	Large extracellular alpha-helical protein
E4U69_RS08055	COG5445	Predicted secreted protein (DUF2300)
E4U69_RS08060	COG5445	Predicted secreted protein (DUF2300)
E4U69_RS08065	COG4676	Protein conserved in bacteria
E4U69_RS08070	COG0784	Response regulator, receiver
E4U69_RS08070	COG2205	protein histidine kinase activity
E4U69_RS08075	COG2197	response regulator
E4U69_RS08080	COG0642	Histidine kinase
E4U69_RS08080	COG2198	Histidine kinase
E4U69_RS08085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U69_RS08090	COG1477	protein flavinylation
E4U69_RS08095	COG2169	Transcriptional regulator
E4U69_RS08095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4U69_RS08100	COG3145	DNA-N1-methyladenine dioxygenase activity
E4U69_RS08105	COG4615	Cyclic peptide transporter
E4U69_RS08120	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS08120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U69_RS08125	COG3062	negative regulation of establishment of protein localization
E4U69_RS08135	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS08140	COG0348	domain, Protein
E4U69_RS08145	COG3043	anaerobic respiration
E4U69_RS08150	COG3005	denitrification pathway
E4U69_RS08155	COG4133	protoheme IX ABC transporter activity
E4U69_RS08160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U69_RS08165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U69_RS08170	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U69_RS08180	COG1138	Cytochrome C-type biogenesis protein
E4U69_RS08185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4U69_RS08190	COG3088	subunit of a heme lyase
E4U69_RS08190	COG4235	cytochrome complex assembly
E4U69_RS08195	COG2197	response regulator
E4U69_RS08220	COG3083	sulfuric ester hydrolase activity
E4U69_RS08240	COG1061	Type III restriction enzyme res subunit
E4U69_RS08245	COG1187	pseudouridine synthase activity
E4U69_RS08260	COG4172	Belongs to the ABC transporter superfamily
E4U69_RS08265	COG4239	(ABC) transporter, permease
E4U69_RS08270	COG4174	ABC transporter (Permease)
E4U69_RS08275	COG4166	transmembrane transport
E4U69_RS08280	COG2200	EAL domain
E4U69_RS08285	COG0791	NLP P60 protein
E4U69_RS08290	COG0671	phosphoesterase, PA-phosphatase related
E4U69_RS08295	COG0523	cobalamin synthesis protein
E4U69_RS08300	COG0246	Mannitol dehydrogenase
E4U69_RS08315	COG2814	Major facilitator Superfamily
E4U69_RS08320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS08320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS08325	COG1105	Belongs to the carbohydrate kinase PfkB family
E4U69_RS08330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS08330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS08330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4U69_RS08335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS08340	COG2313	pseudouridylate synthase activity
E4U69_RS08345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U69_RS08350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U69_RS08360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U69_RS08365	COG1522	sequence-specific DNA binding
E4U69_RS08365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS08375	COG2855	membrane
E4U69_RS08380	COG0583	DNA-binding transcription factor activity
E4U69_RS08385	COG0833	amino acid
E4U69_RS08390	COG4771	TonB-dependent receptor
E4U69_RS08395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4U69_RS08405	COG2311	Membrane
E4U69_RS08410	COG1609	Transcriptional regulator
E4U69_RS08415	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS08420	COG1129	ABC transporter
E4U69_RS08425	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS08430	COG0167	dihydroorotate dehydrogenase activity
E4U69_RS08430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4U69_RS08435	COG0493	'glutamate synthase
E4U69_RS08445	COG2949	membrane
E4U69_RS08455	COG1346	cytolysis
E4U69_RS08470	COG2271	Major facilitator Superfamily
E4U69_RS08485	COG0625	glutathione transferase activity
E4U69_RS08490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U69_RS08495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U69_RS08505	COG1538	Outer membrane efflux protein
E4U69_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS08515	COG0586	Pfam SNARE associated Golgi protein
E4U69_RS08525	COG1686	Belongs to the peptidase S11 family
E4U69_RS08530	COG0277	FAD linked oxidase domain protein
E4U69_RS08535	COG1472	Belongs to the glycosyl hydrolase 3 family
E4U69_RS08540	COG1732	Glycine betaine
E4U69_RS08545	COG1174	glycine betaine transport
E4U69_RS08550	COG1125	glycine betaine transport
E4U69_RS08555	COG1174	glycine betaine transport
E4U69_RS08565	COG0789	Transcriptional regulator
E4U69_RS08570	COG0582	viral genome integration into host DNA
E4U69_RS08815	COG3772	lysozyme
E4U69_RS08955	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS08970	COG3275	phosphorelay sensor kinase activity
E4U69_RS08975	COG3279	Response regulator of the LytR AlgR family
E4U69_RS08980	COG4807	Protein conserved in bacteria
E4U69_RS08985	COG4808	Protein conserved in bacteria
E4U69_RS08990	COG4715	Zinc finger, swim domain protein
E4U69_RS08995	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4U69_RS09000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4U69_RS09005	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4U69_RS09010	COG0714	Associated with various cellular activities
E4U69_RS09020	COG3831	ATPase activity
E4U69_RS09040	COG0489	protein tyrosine kinase activity
E4U69_RS09050	COG3539	Fimbrial protein
E4U69_RS09055	COG3121	Chaperone
E4U69_RS09060	COG3188	usher protein
E4U69_RS09065	COG3539	Fimbrial protein
E4U69_RS09070	COG5455	response to cobalt ion
E4U69_RS09075	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4U69_RS09105	COG0351	phosphomethylpyrimidine kinase
E4U69_RS09110	COG3757	hydrolase, family 25
E4U69_RS09115	COG2188	Transcriptional regulator
E4U69_RS09120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS09125	COG1397	ADP-ribosylglycohydrolase
E4U69_RS09130	COG2211	Major facilitator Superfamily
E4U69_RS09135	COG1830	Aldolase
E4U69_RS09150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS09155	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U69_RS09160	COG3775	system Galactitol-specific IIC component
E4U69_RS09165	COG1063	alcohol dehydrogenase
E4U69_RS09190	COG3422	double-strand break repair
E4U69_RS09195	COG0745	RESPONSE REGULATOR receiver
E4U69_RS09200	COG2205	protein histidine kinase activity
E4U69_RS09215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U69_RS09240	COG4245	von Willebrand factor, type A
E4U69_RS09245	COG0631	protein serine/threonine phosphatase activity
E4U69_RS09250	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E4U69_RS09255	COG0443	Heat shock 70 kDa protein
E4U69_RS09260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4U69_RS09270	COG0572	uridine kinase
E4U69_RS09280	COG2982	Protein involved in outer membrane biogenesis
E4U69_RS09295	COG1253	flavin adenine dinucleotide binding
E4U69_RS09305	COG1596	polysaccharide export
E4U69_RS09310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4U69_RS09315	COG0489	protein tyrosine kinase activity
E4U69_RS09315	COG3206	protein involved in exopolysaccharide biosynthesis
E4U69_RS09320	COG0463	Glycosyl transferase, family 2
E4U69_RS09325	COG1045	serine acetyltransferase
E4U69_RS09330	COG0438	transferase activity, transferring glycosyl groups
E4U69_RS09340	COG1216	Glycosyl transferase, family 2
E4U69_RS09345	COG0110	maltose O-acetyltransferase activity
E4U69_RS09350	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4U69_RS09355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U69_RS09360	COG1051	belongs to the nudix hydrolase family
E4U69_RS09365	COG0297	glycogen (starch) synthase activity
E4U69_RS09370	COG0662	Cupin 2, conserved barrel domain protein
E4U69_RS09370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4U69_RS09375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4U69_RS09380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4U69_RS09385	COG2244	polysaccharide biosynthetic process
E4U69_RS09390	COG2327	Polysaccharide pyruvyl transferase
E4U69_RS09395	COG0438	transferase activity, transferring glycosyl groups
E4U69_RS09405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U69_RS09410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4U69_RS09435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4U69_RS09445	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4U69_RS09450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U69_RS09455	COG1051	belongs to the nudix hydrolase family
E4U69_RS09460	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4U69_RS09460	COG0662	Cupin 2, conserved barrel domain protein
E4U69_RS09465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4U69_RS09475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4U69_RS09480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4U69_RS09505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4U69_RS09510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4U69_RS09510	COG0131	Imidazoleglycerol-phosphate dehydratase
E4U69_RS09520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4U69_RS09535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U69_RS09540	COG0583	DNA-binding transcription factor activity
E4U69_RS09550	COG0531	amino acid
E4U69_RS09555	COG2391	methyltransferase activity
E4U69_RS09560	COG0425	Belongs to the sulfur carrier protein TusA family
E4U69_RS09565	COG2925	Exonuclease
E4U69_RS09570	COG0582	viral genome integration into host DNA
E4U69_RS09590	COG3561	AntA/AntB antirepressor
E4U69_RS09690	COG2815	serine threonine protein kinase
E4U69_RS09690	COG0515	serine threonine protein kinase
E4U69_RS09835	COG3772	lysozyme
E4U69_RS09980	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U69_RS10240	COG3772	lysozyme
E4U69_RS10345	COG1185	polyribonucleotide nucleotidyltransferase activity
E4U69_RS10380	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS10390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U69_RS10400	COG1686	Belongs to the peptidase S11 family
E4U69_RS10410	COG1289	transmembrane transporter activity
E4U69_RS10420	COG4917	ethanolamine utilization protein
E4U69_RS10455	COG2003	Belongs to the UPF0758 family
E4U69_RS10500	COG4771	TonB-dependent receptor
E4U69_RS10505	COG4372	Transposase
E4U69_RS10510	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS10520	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E4U69_RS10535	COG1376	ErfK ybiS ycfS ynhG family protein
E4U69_RS10545	COG0583	DNA-binding transcription factor activity
E4U69_RS10550	COG0583	DNA-binding transcription factor activity
E4U69_RS10570	COG0217	transcriptional regulatory protein
E4U69_RS10575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4U69_RS10580	COG0477	Major facilitator Superfamily
E4U69_RS10590	COG2373	Large extracellular alpha-helical protein
E4U69_RS10590	COG1388	LysM domain
E4U69_RS10590	COG4932	domain protein
E4U69_RS10620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS10665	COG1846	Transcriptional regulator
E4U69_RS10710	COG1403	HNH endonuclease
E4U69_RS10715	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS10770	COG3772	lysozyme
E4U69_RS10800	COG4220	transposase activity
E4U69_RS10890	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS10910	COG3038	cytochrome b561
E4U69_RS10915	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4U69_RS10930	COG2351	hydroxyisourate hydrolase activity
E4U69_RS10935	COG0745	RESPONSE REGULATOR receiver
E4U69_RS10940	COG2205	protein histidine kinase activity
E4U69_RS10960	COG1418	mRNA catabolic process
E4U69_RS10965	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4U69_RS10970	COG3727	T/G mismatch-specific endonuclease activity
E4U69_RS10975	COG0697	spore germination
E4U69_RS10980	COG2354	Protein conserved in bacteria
E4U69_RS10985	COG5475	Uncharacterized small protein (DUF2158)
E4U69_RS10990	COG3706	GGDEF domain
E4U69_RS11010	COG2197	response regulator
E4U69_RS11015	COG1684	flagellar biosynthetic protein fliR
E4U69_RS11020	COG1987	bacterial-type flagellum assembly
E4U69_RS11025	COG1338	Plays a role in the flagellum-specific transport system
E4U69_RS11030	COG3190	flagellar
E4U69_RS11035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U69_RS11040	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U69_RS11045	COG1580	Controls the rotational direction of flagella during chemotaxis
E4U69_RS11050	COG3144	bacterial-type flagellum assembly
E4U69_RS11055	COG2882	bacterial-type flagellum organization
E4U69_RS11060	COG1157	protein secretion by the type III secretion system
E4U69_RS11065	COG1317	bacterial-type flagellum organization
E4U69_RS11070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U69_RS11075	COG1766	The M ring may be actively involved in energy transduction
E4U69_RS11090	COG0454	-acetyltransferase
E4U69_RS11100	COG0454	-acetyltransferase
E4U69_RS11105	COG2135	peptidase activity
E4U69_RS11110	COG0425	Belongs to the sulfur carrier protein TusA family
E4U69_RS11115	COG2391	methyltransferase activity
E4U69_RS11125	COG0366	Alpha amylase catalytic
E4U69_RS11135	COG1516	flagellar protein fliS
E4U69_RS11140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4U69_RS11150	COG1191	sigma factor activity
E4U69_RS11180	COG2197	response regulator
E4U69_RS11195	COG2197	response regulator
E4U69_RS11235	COG2826	transposase and inactivated derivatives, IS30 family
E4U69_RS11285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U69_RS11385	COG4974	Belongs to the 'phage' integrase family
E4U69_RS11390	COG3012	SEC-C Motif Domain Protein
E4U69_RS11390	COG3318	Belongs to the UPF0149 family
E4U69_RS11395	COG0814	amino acid
E4U69_RS11405	COG1528	Iron-storage protein
E4U69_RS11425	COG1528	Iron-storage protein
E4U69_RS11430	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS11435	COG1129	ABC transporter
E4U69_RS11445	COG1877	trehalose-phosphatase activity
E4U69_RS11450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4U69_RS11455	COG0589	response to stress
E4U69_RS11470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4U69_RS11475	COG1360	Flagellar Motor Protein
E4U69_RS11480	COG0643	Histidine kinase
E4U69_RS11480	COG2198	Histidine kinase
E4U69_RS11485	COG0835	chemotaxis
E4U69_RS11490	COG0840	transmembrane signaling receptor activity
E4U69_RS11495	COG0840	transmembrane signaling receptor activity
E4U69_RS11500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4U69_RS11505	COG2201	protein-glutamate methylesterase activity
E4U69_RS11510	COG0745	RESPONSE REGULATOR receiver
E4U69_RS11520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4U69_RS11525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4U69_RS11535	COG3755	Protein conserved in bacteria
E4U69_RS11545	COG3102	Protein conserved in bacteria
E4U69_RS11555	COG3005	denitrification pathway
E4U69_RS11560	COG0243	molybdopterin cofactor binding
E4U69_RS11575	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4U69_RS11580	COG1801	Protein of unknown function DUF72
E4U69_RS11585	COG1335	isochorismatase
E4U69_RS11590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4U69_RS11595	COG0494	nUDIX hydrolase
E4U69_RS11600	COG0217	transcriptional regulatory protein
E4U69_RS11630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4U69_RS11640	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4U69_RS11645	COG0739	heme binding
E4U69_RS11650	COG1560	Kdo2-lipid A biosynthetic process
E4U69_RS11655	COG0469	pyruvate kinase activity
E4U69_RS11660	COG1737	Transcriptional regulator
E4U69_RS11665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4U69_RS11670	COG0129	dihydroxy-acid dehydratase activity
E4U69_RS11675	COG0800	Aldolase
E4U69_RS11680	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4U69_RS11685	COG3141	response to X-ray
E4U69_RS11695	COG2979	Protein of unknown function (DUF533)
E4U69_RS11700	COG1770	oligopeptidase
E4U69_RS11705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS11710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U69_RS11720	COG2372	response to copper ion
E4U69_RS11725	COG1276	copper resistance
E4U69_RS11735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4U69_RS11755	COG3008	intermembrane lipid transfer
E4U69_RS11760	COG2995	paraquat-inducible protein a
E4U69_RS11765	COG1956	GAF domain-containing protein
E4U69_RS11775	COG0793	Belongs to the peptidase S41A family
E4U69_RS11785	COG2814	Major facilitator Superfamily
E4U69_RS11790	COG1414	Transcriptional regulator
E4U69_RS11820	COG2226	methyltransferase
E4U69_RS11835	COG3716	PTS system mannose fructose sorbose family IID component
E4U69_RS11840	COG3715	PTS system
E4U69_RS11845	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS11845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS11850	COG1253	flavin adenine dinucleotide binding
E4U69_RS11855	COG2200	EAL domain
E4U69_RS11860	COG1760	l-serine dehydratase
E4U69_RS11870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4U69_RS11885	COG0251	oxidation-reduction process
E4U69_RS11890	COG1199	ATP-dependent helicase activity
E4U69_RS11895	COG1214	PFAM Peptidase M22, glycoprotease
E4U69_RS11900	COG3065	identical protein binding
E4U69_RS11905	COG0318	PFAM AMP-dependent synthetase and ligase
E4U69_RS11910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4U69_RS11915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U69_RS11920	COG4638	Rieske (2fe-2S)
E4U69_RS11925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4U69_RS11930	COG0473	3-isopropylmalate dehydrogenase activity
E4U69_RS11935	COG0583	DNA-binding transcription factor activity
E4U69_RS11940	COG1280	lysine exporter protein (LysE YggA)
E4U69_RS11945	COG3615	Tellurite resistance protein tehB
E4U69_RS11955	COG2261	transglycosylase associated protein
E4U69_RS11975	COG3042	response to heat
E4U69_RS11980	COG3189	MarR family transcriptional regulator
E4U69_RS11985	COG2807	transmembrane transport
E4U69_RS11990	COG2207	Transcriptional regulator
E4U69_RS12005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4U69_RS12010	COG2199	diguanylate cyclase activity
E4U69_RS12015	COG2199	diguanylate cyclase activity
E4U69_RS12025	COG2766	serine protein kinase
E4U69_RS12030	COG3713	MltA-interacting MipA family protein
E4U69_RS12035	COG0656	L-ascorbic acid biosynthetic process
E4U69_RS12040	COG0676	glucose-6-phosphate 1-epimerase activity
E4U69_RS12045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4U69_RS12055	COG3139	Protein of unknown function (DUF1315)
E4U69_RS12060	COG1063	alcohol dehydrogenase
E4U69_RS12065	COG2271	Major facilitator Superfamily
E4U69_RS12070	COG1063	alcohol dehydrogenase
E4U69_RS12075	COG0191	fructose-bisphosphate aldolase activity
E4U69_RS12080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS12085	COG0667	Aldo Keto reductase
E4U69_RS12090	COG1349	DNA-binding transcription factor activity
E4U69_RS12095	COG2814	Major facilitator Superfamily
E4U69_RS12100	COG1335	isochorismatase
E4U69_RS12105	COG0252	asparaginase activity
E4U69_RS12115	COG0616	signal peptide processing
E4U69_RS12120	COG0778	Nitroreductase
E4U69_RS12125	COG0709	Synthesizes selenophosphate from selenide and ATP
E4U69_RS12130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4U69_RS12140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4U69_RS12150	COG0494	nUDIX hydrolase
E4U69_RS12155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4U69_RS12160	COG2897	thiosulfate sulfurtransferase activity
E4U69_RS12165	COG4136	ATPase activity
E4U69_RS12170	COG4135	transport system, permease component
E4U69_RS12175	COG4134	Bacterial extracellular solute-binding protein
E4U69_RS12180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U69_RS12185	COG0398	Pfam SNARE associated Golgi protein
E4U69_RS12195	COG0398	Pfam SNARE associated Golgi protein
E4U69_RS12200	COG0708	Exodeoxyribonuclease III
E4U69_RS12230	COG3678	ATP-independent chaperone mediated protein folding
E4U69_RS12240	COG0322	excinuclease ABC activity
E4U69_RS12250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U69_RS12255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4U69_RS12260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4U69_RS12265	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4U69_RS12270	COG2169	Transcriptional regulator
E4U69_RS12270	COG1917	Cupin 2, conserved barrel domain protein
E4U69_RS12275	COG1486	melibiose metabolic process
E4U69_RS12285	COG0753	catalase activity
E4U69_RS12305	COG1988	membrane-bound metal-dependent
E4U69_RS12310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U69_RS12320	COG3001	Fructosamine kinase
E4U69_RS12330	COG1105	Belongs to the carbohydrate kinase PfkB family
E4U69_RS12335	COG3137	Salt-induced outer membrane protein
E4U69_RS12380	COG0072	phenylalanine-tRNA ligase activity
E4U69_RS12380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4U69_RS12395	COG0386	Belongs to the glutathione peroxidase family
E4U69_RS12405	COG0791	NLP P60 protein
E4U69_RS12410	COG2200	EAL domain
E4U69_RS12420	COG4256	Hemin uptake protein
E4U69_RS12425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U69_RS12435	COG0574	Belongs to the PEP-utilizing enzyme family
E4U69_RS12435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U69_RS12440	COG0318	PFAM AMP-dependent synthetase and ligase
E4U69_RS12445	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U69_RS12450	COG0644	oxidoreductase
E4U69_RS12455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4U69_RS12460	COG2086	electron transfer activity
E4U69_RS12465	COG2207	Transcriptional regulator
E4U69_RS12465	COG1917	Cupin 2, conserved barrel domain protein
E4U69_RS12470	COG1960	acyl-CoA dehydrogenase activity
E4U69_RS12475	COG4670	ketone body catabolic process
E4U69_RS12490	COG2271	Major facilitator Superfamily
E4U69_RS12495	COG0738	Major facilitator superfamily
E4U69_RS12510	COG0628	permease
E4U69_RS12515	COG0277	FAD linked oxidase domain protein
E4U69_RS12515	COG0247	lactate metabolic process
E4U69_RS12520	COG2050	protein possibly involved in aromatic compounds catabolism
E4U69_RS12530	COG0316	Belongs to the HesB IscA family
E4U69_RS12535	COG0719	Fe-S assembly protein
E4U69_RS12540	COG0396	ATPase activity
E4U69_RS12545	COG0719	Fe-S assembly protein
E4U69_RS12560	COG1376	ErfK ybiS ycfS ynhG family protein
E4U69_RS12565	COG4238	major outer membrane lipoprotein
E4U69_RS12570	COG0469	pyruvate kinase activity
E4U69_RS12580	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS12585	COG2414	aldehyde ferredoxin oxidoreductase
E4U69_RS12595	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS12600	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4U69_RS12610	COG4529	Protein conserved in bacteria
E4U69_RS12635	COG3468	outer membrane autotransporter barrel domain protein
E4U69_RS12645	COG0307	riboflavin synthase, alpha
E4U69_RS12650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4U69_RS12655	COG2814	Major facilitator Superfamily
E4U69_RS12660	COG0583	DNA-binding transcription factor activity
E4U69_RS12675	COG2814	Major facilitator Superfamily
E4U69_RS12680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4U69_RS12685	COG0791	NLP P60 protein
E4U69_RS12690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4U69_RS12695	COG1201	RNA secondary structure unwinding
E4U69_RS12705	COG0346	lactoylglutathione lyase activity
E4U69_RS12710	COG1902	pentaerythritol trinitrate reductase activity
E4U69_RS12715	COG1309	transcriptional regulator
E4U69_RS12720	COG3313	Fe-S protein
E4U69_RS12730	COG2032	superoxide dismutase activity
E4U69_RS12735	COG1289	transmembrane transporter activity
E4U69_RS12740	COG1566	PFAM secretion protein HlyD family protein
E4U69_RS12755	COG3133	Outer membrane lipoprotein
E4U69_RS12765	COG3895	Periplasmic Protein
E4U69_RS12780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4U69_RS12785	COG0625	glutathione transferase activity
E4U69_RS12790	COG3104	oligopeptide transport
E4U69_RS12795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4U69_RS12805	COG4659	FMN binding
E4U69_RS12815	COG4656	Part of a membrane complex involved in electron transport
E4U69_RS12845	COG0673	inositol 2-dehydrogenase activity
E4U69_RS12855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4U69_RS12860	COG1263	PTS System
E4U69_RS12860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS12865	COG1609	Transcriptional regulator
E4U69_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS12875	COG1309	transcriptional regulator
E4U69_RS12895	COG5339	Protein conserved in bacteria
E4U69_RS12900	COG1482	cell wall glycoprotein biosynthetic process
E4U69_RS12905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS12905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS12910	COG0114	fumarate hydratase activity
E4U69_RS12920	COG2205	protein histidine kinase activity
E4U69_RS12925	COG0745	RESPONSE REGULATOR receiver
E4U69_RS12930	COG3136	membrane protein required for alginate biosynthesis
E4U69_RS12940	COG0531	amino acid
E4U69_RS12950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4U69_RS12955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4U69_RS12960	COG0628	permease
E4U69_RS12975	COG3591	Belongs to the peptidase S1B family
E4U69_RS12990	COG2814	Major facilitator Superfamily
E4U69_RS12995	COG0583	DNA-binding transcription factor activity
E4U69_RS13000	COG1940	carbohydrate kinase activity
E4U69_RS13005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4U69_RS13015	COG3381	protein complex oligomerization
E4U69_RS13020	COG3302	dmso reductase anchor subunit
E4U69_RS13025	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS13030	COG0243	molybdopterin cofactor binding
E4U69_RS13035	COG0243	molybdopterin cofactor binding
E4U69_RS13050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U69_RS13075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS13130	COG1846	Transcriptional regulator
E4U69_RS13135	COG1484	DNA-dependent DNA replication
E4U69_RS13170	COG1403	HNH endonuclease
E4U69_RS13175	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS13225	COG3772	lysozyme
E4U69_RS13350	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS13370	COG1473	amidohydrolase
E4U69_RS13375	COG1473	amidohydrolase
E4U69_RS13380	COG0583	DNA-binding transcription factor activity
E4U69_RS13385	COG2840	Smr protein MutS2
E4U69_RS13390	COG3706	GGDEF domain
E4U69_RS13405	COG0513	Belongs to the DEAD box helicase family
E4U69_RS13415	COG0582	viral genome integration into host DNA
E4U69_RS13435	COG3723	Recombinational DNA repair protein, rece pathway
E4U69_RS13440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS13490	COG3756	Protein conserved in bacteria
E4U69_RS13495	COG1484	DNA-dependent DNA replication
E4U69_RS13500	COG1846	Transcriptional regulator
E4U69_RS13600	COG3772	lysozyme
E4U69_RS13725	COG2032	superoxide dismutase activity
E4U69_RS13740	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS13765	COG0589	response to stress
E4U69_RS13775	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4U69_RS13775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4U69_RS13775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U69_RS13775	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4U69_RS13780	COG3042	response to heat
E4U69_RS13785	COG3187	Heat shock protein
E4U69_RS13790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4U69_RS13795	COG2911	Protein conserved in bacteria
E4U69_RS13805	COG3784	Protein of unknown function (DUF1318)
E4U69_RS13820	COG0667	Aldo Keto reductase
E4U69_RS13830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4U69_RS13835	COG4589	Belongs to the CDS family
E4U69_RS13840	COG2267	carboxylic ester hydrolase activity
E4U69_RS13845	COG2453	phosphatase
E4U69_RS13845	COG0671	phosphoesterase, PA-phosphatase related
E4U69_RS13850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4U69_RS13855	COG1643	Atp-dependent helicase
E4U69_RS13880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4U69_RS13885	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS13890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4U69_RS13895	COG3038	cytochrome b561
E4U69_RS13910	COG0840	transmembrane signaling receptor activity
E4U69_RS13915	COG0583	DNA-binding transcription factor activity
E4U69_RS13920	COG5383	Protein conserved in bacteria
E4U69_RS13930	COG2841	Protein conserved in bacteria
E4U69_RS13940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4U69_RS13945	COG1275	C4-dicarboxylate transporter malic acid transport protein
E4U69_RS13950	COG0500	methyltransferase
E4U69_RS13960	COG3135	benzoate transporter
E4U69_RS13965	COG1396	sequence-specific DNA binding
E4U69_RS13970	COG0826	peptidase U32
E4U69_RS13980	COG1724	mRNA binding
E4U69_RS13985	COG1598	PFAM Uncharacterised protein family UPF0150
E4U69_RS13990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4U69_RS13995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U69_RS14000	COG3842	ATPase activity
E4U69_RS14005	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4U69_RS14010	COG1177	transmembrane transport
E4U69_RS14035	COG3238	Protein conserved in bacteria
E4U69_RS14040	COG1247	-acetyltransferase
E4U69_RS14045	COG2130	NADP-dependent
E4U69_RS14050	COG1802	Transcriptional regulator
E4U69_RS14055	COG4772	TonB-dependent receptor
E4U69_RS14060	COG3391	amine dehydrogenase activity
E4U69_RS14065	COG1113	amino acid transport
E4U69_RS14070	COG0625	glutathione transferase activity
E4U69_RS14080	COG3501	Rhs element vgr protein
E4U69_RS14085	COG3209	COG3209 Rhs family protein
E4U69_RS14115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4U69_RS14125	COG0384	phenazine biosynthesis protein PhzF
E4U69_RS14130	COG2181	nitrate reductase activity
E4U69_RS14135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4U69_RS14140	COG1140	nitrate reductase beta subunit
E4U69_RS14145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4U69_RS14150	COG2223	nitrite transmembrane transporter activity
E4U69_RS14155	COG4886	Leucine-rich repeat (LRR) protein
E4U69_RS14160	COG4886	Leucine-rich repeat (LRR) protein
E4U69_RS14175	COG0697	spore germination
E4U69_RS14185	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS14190	COG2864	formate dehydrogenase
E4U69_RS14195	COG3093	addiction module antidote protein HigA
E4U69_RS14200	COG1064	alcohol dehydrogenase
E4U69_RS14220	COG1764	response to oxidative stress
E4U69_RS14225	COG4608	Belongs to the ABC transporter superfamily
E4U69_RS14230	COG0444	Belongs to the ABC transporter superfamily
E4U69_RS14235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U69_RS14240	COG0601	transmembrane transport
E4U69_RS14245	COG0747	negative chemotaxis
E4U69_RS14250	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4U69_RS14260	COG3706	GGDEF domain
E4U69_RS14270	COG0531	amino acid
E4U69_RS14275	COG0076	glutamate decarboxylase activity
E4U69_RS14280	COG0612	Peptidase, M16
E4U69_RS14285	COG4771	TonB-dependent receptor
E4U69_RS14290	COG4178	(ABC) transporter
E4U69_RS14300	COG0641	radical SAM
E4U69_RS14305	COG3119	arylsulfatase activity
E4U69_RS14310	COG2207	Transcriptional regulator
E4U69_RS14320	COG0243	molybdopterin cofactor binding
E4U69_RS14325	COG3539	Fimbrial protein
E4U69_RS14330	COG3539	Fimbrial protein
E4U69_RS14335	COG3539	Fimbrial protein
E4U69_RS14340	COG3188	usher protein
E4U69_RS14350	COG3539	Fimbrial protein
E4U69_RS14360	COG3550	peptidyl-serine autophosphorylation
E4U69_RS14365	COG3210	domain, Protein
E4U69_RS14365	COG2911	Protein conserved in bacteria
E4U69_RS14370	COG1070	Carbohydrate kinase
E4U69_RS14380	COG1129	ABC transporter
E4U69_RS14385	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS14390	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS14400	COG1830	Aldolase
E4U69_RS14415	COG3781	membrane
E4U69_RS14425	COG2199	diguanylate cyclase activity
E4U69_RS14435	COG2066	Belongs to the glutaminase family
E4U69_RS14440	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS14445	COG0583	DNA-binding transcription factor activity
E4U69_RS14460	COG2814	Major facilitator Superfamily
E4U69_RS14465	COG2095	MarC family integral membrane protein
E4U69_RS14470	COG1846	Transcriptional regulator
E4U69_RS14475	COG4977	sequence-specific DNA binding
E4U69_RS14485	COG0697	spore germination
E4U69_RS14490	COG2814	Major facilitator Superfamily
E4U69_RS14510	COG3706	GGDEF domain
E4U69_RS14515	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U69_RS14520	COG1546	Belongs to the CinA family
E4U69_RS14525	COG0339	signal peptide processing
E4U69_RS14530	COG4221	oxidoreductase activity
E4U69_RS14535	COG1802	Transcriptional regulator
E4U69_RS14545	COG0246	Mannitol dehydrogenase
E4U69_RS14550	COG0477	Major facilitator Superfamily
E4U69_RS14580	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS14665	COG1030	water channel activity
E4U69_RS14685	COG4220	transposase activity
E4U69_RS14715	COG3772	lysozyme
E4U69_RS14755	COG2207	Transcriptional regulator
E4U69_RS14770	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS14775	COG1403	HNH endonuclease
E4U69_RS14785	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U69_RS14820	COG1846	Transcriptional regulator
E4U69_RS14875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS14900	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS14905	COG4372	Transposase
E4U69_RS14935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4U69_RS14940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U69_RS14945	COG0589	response to stress
E4U69_RS14950	COG3182	Iron-regulated membrane protein
E4U69_RS14955	COG0668	transmembrane transport
E4U69_RS14960	COG4166	transmembrane transport
E4U69_RS14965	COG0583	DNA-binding transcription factor activity
E4U69_RS14970	COG1073	alpha beta
E4U69_RS14980	COG0702	epimerase
E4U69_RS14985	COG2866	Carboxypeptidase
E4U69_RS14990	COG4948	Mandelate Racemase Muconate Lactonizing
E4U69_RS14995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4U69_RS15000	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E4U69_RS15010	COG3106	COG3106 Predicted ATPase
E4U69_RS15015	COG1609	Transcriptional regulator
E4U69_RS15025	COG3842	ATPase activity
E4U69_RS15030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U69_RS15035	COG1554	hydrolase, family 65, central catalytic
E4U69_RS15040	COG0673	inositol 2-dehydrogenase activity
E4U69_RS15045	COG1082	Xylose isomerase domain protein TIM barrel
E4U69_RS15050	COG1063	alcohol dehydrogenase
E4U69_RS15055	COG0395	ABC-type sugar transport system, permease component
E4U69_RS15060	COG1175	transmembrane transport
E4U69_RS15075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U69_RS15085	COG1983	PspC domain protein
E4U69_RS15095	COG1842	Phage shock protein A
E4U69_RS15100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4U69_RS15105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4U69_RS15110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4U69_RS15115	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS15120	COG1917	Cupin 2, conserved barrel domain protein
E4U69_RS15120	COG1396	sequence-specific DNA binding
E4U69_RS15125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4U69_RS15130	COG0174	glutamine synthetase
E4U69_RS15140	COG0531	amino acid
E4U69_RS15150	COG4166	transmembrane transport
E4U69_RS15155	COG4168	peptide transport system, permease
E4U69_RS15160	COG4171	peptide transport system, permease
E4U69_RS15165	COG4172	Belongs to the ABC transporter superfamily
E4U69_RS15170	COG4172	Belongs to the ABC transporter superfamily
E4U69_RS15175	COG2814	Major facilitator Superfamily
E4U69_RS15190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS15200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4U69_RS15205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U69_RS15205	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U69_RS15215	COG5001	Diguanylate cyclase
E4U69_RS15225	COG1349	DNA-binding transcription factor activity
E4U69_RS15235	COG0023	Translation Initiation Factor
E4U69_RS15245	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4U69_RS15250	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E4U69_RS15255	COG0671	phosphoesterase, PA-phosphatase related
E4U69_RS15265	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4U69_RS15285	COG0583	DNA-binding transcription factor activity
E4U69_RS15290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4U69_RS15300	COG0616	signal peptide processing
E4U69_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS15310	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4U69_RS15315	COG1187	pseudouridine synthase activity
E4U69_RS15320	COG4907	membrane protein (DUF2207)
E4U69_RS15325	COG0009	L-threonylcarbamoyladenylate synthase
E4U69_RS15330	COG0613	PHP domain protein
E4U69_RS15340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4U69_RS15345	COG0512	Glutamine amidotransferase of anthranilate synthase
E4U69_RS15345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4U69_RS15350	COG0134	indole-3-glycerol-phosphate synthase activity
E4U69_RS15350	COG0135	phosphoribosylanthranilate isomerase activity
E4U69_RS15365	COG3729	General stress protein
E4U69_RS15370	COG3685	Protein conserved in bacteria
E4U69_RS15375	COG3685	Protein conserved in bacteria
E4U69_RS15425	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS15430	COG4372	Transposase
E4U69_RS15475	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS15610	COG3772	lysozyme
E4U69_RS15660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U69_RS15685	COG3299	homolog of phage Mu protein gp47
E4U69_RS15695	COG4384	Bacteriophage Mu Gp45 protein
E4U69_RS15715	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
E4U69_RS15725	COG4386	tail sheath protein
E4U69_RS15750	COG4397	Mu-like prophage major head subunit gpT
E4U69_RS15755	COG4388	Caudovirus prohead serine protease
E4U69_RS15760	COG5005	Phage virion morphogenesis
E4U69_RS15770	COG2369	cell adhesion
E4U69_RS15775	COG4383	Mu-like prophage protein gp29
E4U69_RS15780	COG4373	Mu-like prophage FluMu protein gp28
E4U69_RS15820	COG5566	PFAM Mor transcription activator
E4U69_RS15870	COG4396	Host-nuclease inhibitor protein Gam
E4U69_RS15900	COG2842	Transposition protein
E4U69_RS15950	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS15955	COG1403	HNH endonuclease
E4U69_RS15985	COG1846	Transcriptional regulator
E4U69_RS16010	COG1396	sequence-specific DNA binding
E4U69_RS16055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS16065	COG0582	viral genome integration into host DNA
E4U69_RS16070	COG3047	cAMP biosynthetic process
E4U69_RS16090	COG1607	acyl-coa hydrolase
E4U69_RS16095	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4U69_RS16100	COG2350	Protein conserved in bacteria
E4U69_RS16105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4U69_RS16125	COG4608	Belongs to the ABC transporter superfamily
E4U69_RS16130	COG0444	Belongs to the ABC transporter superfamily
E4U69_RS16135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U69_RS16140	COG0601	transmembrane transport
E4U69_RS16145	COG4166	transmembrane transport
E4U69_RS16150	COG2095	MarC family integral membrane protein
E4U69_RS16155	COG1012	belongs to the aldehyde dehydrogenase family
E4U69_RS16155	COG1454	alcohol dehydrogenase
E4U69_RS16160	COG1435	thymidine kinase activity
E4U69_RS16170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4U69_RS16175	COG0745	RESPONSE REGULATOR receiver
E4U69_RS16180	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4U69_RS16190	COG0788	formyltetrahydrofolate deformylase activity
E4U69_RS16220	COG2181	nitrate reductase activity
E4U69_RS16225	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4U69_RS16230	COG1140	nitrate reductase beta subunit
E4U69_RS16235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4U69_RS16240	COG2223	nitrite transmembrane transporter activity
E4U69_RS16245	COG3850	Histidine kinase
E4U69_RS16250	COG2197	response regulator
E4U69_RS16255	COG4932	domain protein
E4U69_RS16260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4U69_RS16265	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4U69_RS16270	COG4572	Cation transport regulator
E4U69_RS16275	COG0387	Pfam Sodium calcium exchanger
E4U69_RS16295	COG2912	Transglutaminase-like superfamily
E4U69_RS16300	COG3094	Invasion gene expression up-regulator, SirB
E4U69_RS16330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4U69_RS16335	COG0659	secondary active sulfate transmembrane transporter activity
E4U69_RS16350	COG0012	GTP binding
E4U69_RS16360	COG2376	Dihydroxyacetone kinase
E4U69_RS16365	COG1461	Dihydroxyacetone kinase
E4U69_RS16370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS16370	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4U69_RS16370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U69_RS16395	COG1120	ATPase activity
E4U69_RS16405	COG0157	Belongs to the NadC ModD family
E4U69_RS16420	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E4U69_RS16430	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4U69_RS16440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4U69_RS16450	COG2719	SpoVR family
E4U69_RS16465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4U69_RS16470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4U69_RS16475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4U69_RS16490	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4U69_RS16520	COG2894	cell division
E4U69_RS16550	COG4571	Outer membrane protease
E4U69_RS16560	COG4372	Transposase
E4U69_RS16570	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS16585	COG0500	methyltransferase
E4U69_RS16590	COG3729	General stress protein
E4U69_RS16595	COG3685	Protein conserved in bacteria
E4U69_RS16600	COG3685	Protein conserved in bacteria
E4U69_RS16605	COG3546	catalase activity
E4U69_RS16610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U69_RS16615	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS16650	COG1196	nuclear chromosome segregation
E4U69_RS16700	COG1030	water channel activity
E4U69_RS16720	COG4220	transposase activity
E4U69_RS16735	COG5562	phage envelope protein
E4U69_RS16770	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS16790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U69_RS16800	COG2076	Multidrug Resistance protein
E4U69_RS16825	COG0582	viral genome integration into host DNA
E4U69_RS16830	COG0538	isocitrate dehydrogenase activity
E4U69_RS16835	COG1187	pseudouridine synthase activity
E4U69_RS16845	COG0482	sulfurtransferase activity
E4U69_RS16855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4U69_RS16860	COG0745	RESPONSE REGULATOR receiver
E4U69_RS16865	COG2205	protein histidine kinase activity
E4U69_RS16870	COG2850	peptidyl-arginine hydroxylation
E4U69_RS16880	COG3842	ATPase activity
E4U69_RS17075	COG3772	lysozyme
E4U69_RS17115	COG0484	heat shock protein binding
E4U69_RS17120	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS17125	COG1403	HNH endonuclease
E4U69_RS17180	COG1846	Transcriptional regulator
E4U69_RS17200	COG4197	protein conserved in bacteria, prophage-related
E4U69_RS17230	COG0582	viral genome integration into host DNA
E4U69_RS17235	COG1177	transmembrane transport
E4U69_RS17240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U69_RS17245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4U69_RS17255	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4U69_RS17260	COG1136	(ABC) transporter
E4U69_RS17265	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4U69_RS17270	COG4763	Acyl-transferase
E4U69_RS17275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4U69_RS17280	COG1376	ErfK ybiS ycfS ynhG family protein
E4U69_RS17280	COG1388	LysM domain
E4U69_RS17290	COG1309	transcriptional regulator
E4U69_RS17295	COG3134	Outer membrane lipoprotein
E4U69_RS17300	COG1252	NADH dehydrogenase
E4U69_RS17315	COG0510	thiamine kinase activity
E4U69_RS17320	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E4U69_RS17325	COG5633	Lipoprotein
E4U69_RS17330	COG0537	adenosine 5'-monophosphoramidase activity
E4U69_RS17340	COG4773	Receptor
E4U69_RS17345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS17345	COG1263	PTS System
E4U69_RS17350	COG0084	hydrolase, TatD family'
E4U69_RS17355	COG0470	DNA polymerase III
E4U69_RS17365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4U69_RS17370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4U69_RS17375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U69_RS17385	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS17390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4U69_RS17410	COG1399	metal-binding, possibly nucleic acid-binding protein
E4U69_RS17415	COG0424	maF-like protein
E4U69_RS17420	COG0564	pseudouridine synthase activity
E4U69_RS17425	COG1530	ribonuclease E activity
E4U69_RS17430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4U69_RS17435	COG1256	bacterial-type flagellum assembly
E4U69_RS17440	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4U69_RS17440	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4U69_RS17455	COG4786	Flagellar basal body rod
E4U69_RS17460	COG4787	bacterial-type flagellum-dependent cell motility
E4U69_RS17465	COG1749	Flagellar hook protein flgE
E4U69_RS17470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4U69_RS17475	COG1558	bacterial-type flagellum-dependent cell motility
E4U69_RS17480	COG1815	bacterial-type flagellum-dependent cell motility
E4U69_RS17485	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4U69_RS17490	COG2747	anti-sigma28 factor FlgM
E4U69_RS17495	COG3418	PFAM FlgN family protein
E4U69_RS17500	COG0728	peptidoglycan biosynthetic process
E4U69_RS17505	COG0673	inositol 2-dehydrogenase activity
E4U69_RS17515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U69_RS17525	COG2999	glutathione oxidoreductase activity
E4U69_RS17560	COG3038	cytochrome b561
E4U69_RS17565	COG2353	YceI-like domain
E4U69_RS17575	COG1560	Kdo2-lipid A biosynthetic process
E4U69_RS17590	COG5645	(Lipo)protein
E4U69_RS17595	COG2943	transferase activity, transferring hexosyl groups
E4U69_RS17610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U69_RS17615	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U69_RS17640	COG2197	response regulator
E4U69_RS17655	COG1462	curli production assembly transport component CsgG
E4U69_RS17665	COG3381	protein complex oligomerization
E4U69_RS17715	COG2003	Belongs to the UPF0758 family
E4U69_RS17745	COG3468	outer membrane autotransporter barrel domain protein
E4U69_RS17790	COG1475	DNA binding
E4U69_RS17795	COG3969	phosphoadenosine phosphosulfate
E4U69_RS17805	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E4U69_RS17815	COG2831	hemolysin activation secretion protein
E4U69_RS17900	COG4771	TonB-dependent receptor
E4U69_RS17960	COG1358	cellular component organization or biogenesis
E4U69_RS17995	COG4372	Transposase
E4U69_RS18000	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS18030	COG0254	rRNA binding
E4U69_RS18075	COG0829	nickel cation binding
E4U69_RS18085	COG2194	sulfuric ester hydrolase activity
E4U69_RS18090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4U69_RS18130	COG4983	Phage plasmid primase, P4 family domain protein
E4U69_RS18155	COG0582	viral genome integration into host DNA
E4U69_RS18205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U69_RS18210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4U69_RS18220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4U69_RS18230	COG0736	holo-[acyl-carrier-protein] synthase activity
E4U69_RS18235	COG2831	hemolysin activation secretion protein
E4U69_RS18240	COG3210	domain, Protein
E4U69_RS18250	COG3539	Fimbrial protein
E4U69_RS18260	COG3188	usher protein
E4U69_RS18270	COG3121	Chaperone
E4U69_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS18280	COG3710	Transcriptional regulator
E4U69_RS18290	COG2200	EAL domain
E4U69_RS18295	COG3706	GGDEF domain
E4U69_RS18300	COG0457	Tetratricopeptide repeat
E4U69_RS18305	COG1649	PFAM Uncharacterised BCR, COG1649
E4U69_RS18305	COG0726	polysaccharide deacetylase
E4U69_RS18310	COG1215	transferase activity, transferring glycosyl groups
E4U69_RS18315	COG3658	cytochrome
E4U69_RS18320	COG1702	phosphate starvation-inducible protein PhoH
E4U69_RS18325	COG2837	iron assimilation
E4U69_RS18330	COG2822	iron ion transport
E4U69_RS18345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4U69_RS18355	COG0506	proline dehydrogenase activity
E4U69_RS18355	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U69_RS18355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U69_RS18360	COG1309	transcriptional regulator
E4U69_RS18395	COG2233	PERMEase
E4U69_RS18400	COG3729	General stress protein
E4U69_RS18440	COG0243	molybdopterin cofactor binding
E4U69_RS18445	COG3005	denitrification pathway
E4U69_RS18450	COG0745	RESPONSE REGULATOR receiver
E4U69_RS18455	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS18460	COG2198	Histidine kinase
E4U69_RS18460	COG0784	Response regulator, receiver
E4U69_RS18460	COG2205	protein histidine kinase activity
E4U69_RS18465	COG0348	domain, Protein
E4U69_RS18485	COG1278	Cold shock
E4U69_RS18490	COG1278	Cold shock
E4U69_RS18510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U69_RS18515	COG1596	polysaccharide export
E4U69_RS18520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4U69_RS18525	COG3206	protein involved in exopolysaccharide biosynthesis
E4U69_RS18525	COG0489	protein tyrosine kinase activity
E4U69_RS18540	COG1294	oxidase, subunit
E4U69_RS18545	COG1271	oxidase subunit
E4U69_RS18550	COG1773	rubredoxin
E4U69_RS18555	COG1999	signal sequence binding
E4U69_RS18560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U69_RS18565	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E4U69_RS18570	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4U69_RS18575	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4U69_RS18595	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS18610	COG2032	superoxide dismutase activity
E4U69_RS18690	COG4372	Transposase
E4U69_RS18695	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS18720	COG3772	lysozyme
E4U69_RS18770	COG2207	Transcriptional regulator
E4U69_RS18790	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U69_RS18795	COG1403	HNH endonuclease
E4U69_RS18825	COG1846	Transcriptional regulator
E4U69_RS18830	COG1484	DNA-dependent DNA replication
E4U69_RS18895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS18910	COG0670	Belongs to the BI1 family
E4U69_RS18915	COG2920	part of a sulfur-relay system
E4U69_RS18920	COG1254	Belongs to the acylphosphatase family
E4U69_RS18935	COG1832	CoA-binding protein
E4U69_RS18950	COG0210	DNA helicase
E4U69_RS18955	COG3304	Inner membrane component domain
E4U69_RS18960	COG1289	transmembrane transporter activity
E4U69_RS18965	COG3070	regulator of competence-specific genes
E4U69_RS18975	COG2885	chlorophyll binding
E4U69_RS18975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4U69_RS18985	COG1067	ATP-dependent peptidase activity
E4U69_RS18995	COG3130	regulation of translation
E4U69_RS19000	COG3009	Protein conserved in bacteria
E4U69_RS19005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4U69_RS19005	COG3008	intermembrane lipid transfer
E4U69_RS19010	COG2995	paraquat-inducible protein a
E4U69_RS19015	COG0488	(ABC) transporter
E4U69_RS19025	COG3217	Mosc domain protein beta barrel domain protein
E4U69_RS19025	COG0633	Ferredoxin
E4U69_RS19045	COG3539	Fimbrial protein
E4U69_RS19050	COG3539	Fimbrial protein
E4U69_RS19055	COG3539	Fimbrial protein
E4U69_RS19065	COG3121	Chaperone
E4U69_RS19070	COG3539	Fimbrial protein
E4U69_RS19075	COG0431	NADPH-dependent FMN reductase
E4U69_RS19080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4U69_RS19090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4U69_RS19095	COG1116	anion transmembrane transporter activity
E4U69_RS19100	COG0308	aminopeptidase N
E4U69_RS19110	COG0017	Asparaginyl-tRNA synthetase
E4U69_RS19115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U69_RS19120	COG1448	Aminotransferase
E4U69_RS19125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4U69_RS19130	COG3108	Peptidase M15
E4U69_RS19135	COG2989	Protein conserved in bacteria
E4U69_RS19145	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4U69_RS19155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4U69_RS19160	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4U69_RS19165	COG3173	Aminoglycoside phosphotransferase
E4U69_RS19180	COG3214	Protein conserved in bacteria
E4U69_RS19190	COG1132	(ABC) transporter
E4U69_RS19195	COG0658	competence protein
E4U69_RS19195	COG2333	competence protein COMEC
E4U69_RS19205	COG0539	negative regulation of cytoplasmic translation
E4U69_RS19215	COG0501	Belongs to the peptidase M48B family
E4U69_RS19230	COG2323	membrane
E4U69_RS19235	COG1944	ATP diphosphatase activity
E4U69_RS19240	COG2116	formate transmembrane transporter activity
E4U69_RS19245	COG1882	Formate acetyltransferase
E4U69_RS19250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U69_RS19260	COG0531	amino acid
E4U69_RS19270	COG1335	isochorismatase
E4U69_RS19275	COG3302	dmso reductase anchor subunit
E4U69_RS19280	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS19285	COG0243	molybdopterin cofactor binding
E4U69_RS19295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4U69_RS19305	COG1178	ABC-type Fe3 transport system permease component
E4U69_RS19305	COG1674	ftsk spoiiie
E4U69_RS19310	COG1522	sequence-specific DNA binding
E4U69_RS19315	COG0492	ferredoxin-NADP+ reductase activity
E4U69_RS19320	COG4988	ABC transporter
E4U69_RS19325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4U69_RS19345	COG0542	response to heat
E4U69_RS19360	COG2391	methyltransferase activity
E4U69_RS19365	COG4372	Transposase
E4U69_RS19370	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS19450	COG1278	Cold shock
E4U69_RS19455	COG0577	efflux transmembrane transporter activity
E4U69_RS19455	COG1136	(ABC) transporter
E4U69_RS19460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS19465	COG2990	Protein conserved in bacteria
E4U69_RS19470	COG3593	DNA synthesis involved in DNA repair
E4U69_RS19475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4U69_RS19480	COG2431	L-lysine efflux transmembrane transporter activity
E4U69_RS19490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U69_RS19495	COG0028	Belongs to the TPP enzyme family
E4U69_RS19500	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4U69_RS19505	COG0702	epimerase
E4U69_RS19510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U69_RS19515	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4U69_RS19535	COG1126	abc transporter atp-binding protein
E4U69_RS19540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS19545	COG4215	(ABC) transporter
E4U69_RS19550	COG4160	amino acid transport
E4U69_RS19555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS19585	COG1177	transmembrane transport
E4U69_RS19590	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4U69_RS19595	COG3842	ATPase activity
E4U69_RS19600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U69_RS19615	COG0778	Nitroreductase
E4U69_RS19625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U69_RS19640	COG3226	Transcriptional regulator
E4U69_RS19645	COG0738	Major facilitator superfamily
E4U69_RS19650	COG0561	phosphatase activity
E4U69_RS19660	COG2814	Major facilitator Superfamily
E4U69_RS19665	COG0671	phosphoesterase, PA-phosphatase related
E4U69_RS19670	COG1349	DNA-binding transcription factor activity
E4U69_RS19675	COG1686	Belongs to the peptidase S11 family
E4U69_RS19680	COG0625	glutathione transferase activity
E4U69_RS19685	COG2133	pyrroloquinoline quinone binding
E4U69_RS19710	COG2199	diguanylate cyclase activity
E4U69_RS19715	COG2200	EAL domain
E4U69_RS19725	COG0601	transmembrane transport
E4U69_RS19730	COG0747	negative chemotaxis
E4U69_RS19735	COG4172	Belongs to the ABC transporter superfamily
E4U69_RS19745	COG0303	'Molybdopterin
E4U69_RS19750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4U69_RS19755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U69_RS19760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U69_RS19770	COG0561	phosphatase activity
E4U69_RS19780	COG0488	(ABC) transporter
E4U69_RS19785	COG1376	ErfK ybiS ycfS ynhG family protein
E4U69_RS19790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4U69_RS19795	COG1321	iron dependent repressor
E4U69_RS19805	COG2194	sulfuric ester hydrolase activity
E4U69_RS19810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4U69_RS19820	COG5006	permease, DMT superfamily
E4U69_RS19830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS19835	COG0765	amino acid transport
E4U69_RS19840	COG1126	abc transporter atp-binding protein
E4U69_RS19845	COG0668	transmembrane transport
E4U69_RS19860	COG4774	siderophore transport
E4U69_RS19870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4U69_RS19880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4U69_RS19885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4U69_RS19890	COG1199	ATP-dependent helicase activity
E4U69_RS19900	COG0513	Belongs to the DEAD box helicase family
E4U69_RS19905	COG1309	transcriptional regulator
E4U69_RS19915	COG1131	(ABC) transporter
E4U69_RS19920	COG0842	Transport permease protein
E4U69_RS19925	COG0842	Transport permease protein
E4U69_RS19935	COG3568	Endonuclease Exonuclease Phosphatase
E4U69_RS19940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U69_RS19945	COG0392	lysyltransferase activity
E4U69_RS19950	COG0670	Belongs to the BI1 family
E4U69_RS19955	COG0670	Belongs to the BI1 family
E4U69_RS19960	COG0314	molybdopterin synthase activity
E4U69_RS19965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4U69_RS19975	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4U69_RS19985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4U69_RS19995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4U69_RS20000	COG2226	methyltransferase
E4U69_RS20015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4U69_RS20020	COG1881	PFAM PEBP family protein
E4U69_RS20060	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS20145	COG0740	serine-type endopeptidase activity
E4U69_RS20190	COG3772	lysozyme
E4U69_RS20305	COG0582	viral genome integration into host DNA
E4U69_RS20310	COG4677	pectinesterase activity
E4U69_RS20315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4U69_RS20320	COG0471	metal ion transport
E4U69_RS20325	COG2828	Protein conserved in bacteria
E4U69_RS20330	COG0583	DNA-binding transcription factor activity
E4U69_RS20340	COG0561	phosphatase activity
E4U69_RS20350	COG4149	molybdate abc transporter
E4U69_RS20355	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4U69_RS20365	COG2005	Transcriptional regulator
E4U69_RS20365	COG3585	molybdate ion transport
E4U69_RS20370	COG1119	ATPase activity
E4U69_RS20375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4U69_RS20380	COG1085	galactose-1-phosphate uridylyltransferase
E4U69_RS20390	COG2017	converts alpha-aldose to the beta-anomer
E4U69_RS20400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U69_RS20410	COG1230	cation diffusion facilitator family transporter
E4U69_RS20415	COG3201	nicotinamide mononucleotide transporter
E4U69_RS20420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4U69_RS20455	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4U69_RS20460	COG2885	chlorophyll binding
E4U69_RS20470	COG3064	Membrane
E4U69_RS20475	COG0848	biopolymer transport protein
E4U69_RS20480	COG0811	peptide transport
E4U69_RS20485	COG0824	Thioesterase
E4U69_RS20490	COG3790	cyd operon protein YbgE
E4U69_RS20495	COG4890	Cyd operon protein YbgT
E4U69_RS20500	COG1294	oxidase, subunit
E4U69_RS20505	COG1271	oxidase subunit
E4U69_RS20520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U69_RS20530	COG4865	methylaspartate mutase activity
E4U69_RS20535	COG3799	methylaspartate ammonia-lyase activity
E4U69_RS20550	COG1301	dicarboxylic acid transport
E4U69_RS20555	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS20555	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS20560	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4U69_RS20565	COG0583	DNA-binding transcription factor activity
E4U69_RS20570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U69_RS20580	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4U69_RS20585	COG0567	Dehydrogenase, E1 component
E4U69_RS20590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4U69_RS20595	COG1053	succinate dehydrogenase
E4U69_RS20600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4U69_RS20605	COG2009	succinate dehydrogenase
E4U69_RS20615	COG0372	Belongs to the citrate synthase family
E4U69_RS20620	COG3539	Fimbrial protein
E4U69_RS20630	COG3121	Chaperone
E4U69_RS20635	COG3539	Fimbrial protein
E4U69_RS20640	COG3180	Ammonia monooxygenase
E4U69_RS20645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4U69_RS20655	COG1984	allophanate hydrolase subunit 2
E4U69_RS20660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4U69_RS20665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4U69_RS20670	COG3104	oligopeptide transport
E4U69_RS20675	COG0415	Belongs to the DNA photolyase family
E4U69_RS20680	COG3272	Protein of unknown function (DUF1722)
E4U69_RS20700	COG3209	COG3209 Rhs family protein
E4U69_RS20730	COG2205	protein histidine kinase activity
E4U69_RS20735	COG0745	RESPONSE REGULATOR receiver
E4U69_RS20745	COG1982	Orn Lys Arg decarboxylase major
E4U69_RS20750	COG0531	amino acid
E4U69_RS20755	COG0033	Phosphoglucomutase
E4U69_RS20760	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4U69_RS20765	COG0596	Alpha beta hydrolase
E4U69_RS20775	COG0716	FMN binding
E4U69_RS20785	COG0735	belongs to the Fur family
E4U69_RS20805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS20805	COG1263	PTS System
E4U69_RS20805	COG2190	(PTS) system
E4U69_RS20815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U69_RS20820	COG1940	carbohydrate kinase activity
E4U69_RS20820	COG1846	Transcriptional regulator
E4U69_RS20825	COG0647	UMP catabolic process
E4U69_RS20830	COG0367	asparagine synthase
E4U69_RS20870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U69_RS20880	COG1702	phosphate starvation-inducible protein PhoH
E4U69_RS20890	COG4535	Mg2 and Co2 transporter CorC
E4U69_RS20895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4U69_RS20900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U69_RS20905	COG0765	amino acid transport
E4U69_RS20910	COG0765	amino acid transport
E4U69_RS20915	COG1126	abc transporter atp-binding protein
E4U69_RS20925	COG0443	Heat shock 70 kDa protein
E4U69_RS20940	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U69_RS20945	COG2214	Heat shock protein DnaJ domain protein
E4U69_RS20960	COG2888	peptidyl-tyrosine sulfation
E4U69_RS20975	COG1466	dna polymerase III delta subunit
E4U69_RS20985	COG0406	alpha-ribazole phosphatase activity
E4U69_RS20990	COG0799	negative regulation of ribosome biogenesis
E4U69_RS21000	COG0768	penicillin binding
E4U69_RS21005	COG0772	Belongs to the SEDS family
E4U69_RS21010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4U69_RS21015	COG1686	Belongs to the peptidase S11 family
E4U69_RS21030	COG0583	DNA-binding transcription factor activity
E4U69_RS21040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U69_RS21045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U69_RS21065	COG3069	C4-dicarboxylate transmembrane transporter activity
E4U69_RS21070	COG4565	transcriptional regulatory protein
E4U69_RS21075	COG3290	protein histidine kinase activity
E4U69_RS21080	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4U69_RS21090	COG2301	Belongs to the HpcH HpaI aldolase family
E4U69_RS21095	COG3051	citrate lyase alpha subunit
E4U69_RS21105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4U69_RS21110	COG0471	metal ion transport
E4U69_RS21115	COG3719	Belongs to the RNase T2 family
E4U69_RS21120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U69_RS21125	COG1063	alcohol dehydrogenase
E4U69_RS21130	COG0589	response to stress
E4U69_RS21135	COG3634	alkyl hydroperoxide reductase activity
E4U69_RS21140	COG0450	alkyl hydroperoxide reductase
E4U69_RS21145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U69_RS21150	COG0583	DNA-binding transcription factor activity
E4U69_RS21155	COG3969	phosphoadenosine phosphosulfate
E4U69_RS21160	COG1475	DNA binding
E4U69_RS21165	COG0436	Aminotransferase
E4U69_RS21170	COG0371	Dehydrogenase
E4U69_RS21175	COG2879	small protein
E4U69_RS21180	COG1966	Carbon starvation protein
E4U69_RS21190	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS21195	COG3433	isochorismatase activity
E4U69_RS21195	COG1535	isochorismatase
E4U69_RS21200	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4U69_RS21205	COG1169	isochorismate synthase
E4U69_RS21210	COG4592	Periplasmic binding protein
E4U69_RS21220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U69_RS21225	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U69_RS21230	COG1120	ATPase activity
E4U69_RS21235	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4U69_RS21240	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4U69_RS21240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4U69_RS21245	COG3251	PFAM MbtH domain protein
E4U69_RS21250	COG2382	esterase
E4U69_RS21255	COG4771	TonB-dependent receptor
E4U69_RS21260	COG2977	Belongs to the P-Pant transferase superfamily
E4U69_RS21285	COG2315	Protein conserved in bacteria
E4U69_RS21290	COG0778	Nitroreductase
E4U69_RS21295	COG0668	transmembrane transport
E4U69_RS21300	COG1113	amino acid transport
E4U69_RS21305	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U69_RS21310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS21315	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS21320	COG1538	Outer membrane efflux protein
E4U69_RS21325	COG0745	RESPONSE REGULATOR receiver
E4U69_RS21330	COG5002	protein histidine kinase activity
E4U69_RS21335	COG3501	Rhs element vgr protein
E4U69_RS21345	COG3209	COG3209 Rhs family protein
E4U69_RS21345	COG4104	PAAR repeat-containing protein
E4U69_RS21355	COG4104	PAAR repeat-containing protein
E4U69_RS21355	COG3209	COG3209 Rhs family protein
E4U69_RS21365	COG5433	transposase activity
E4U69_RS21370	COG1215	transferase activity, transferring glycosyl groups
E4U69_RS21375	COG4783	chaperone-mediated protein folding
E4U69_RS21385	COG2207	Transcriptional regulator
E4U69_RS21395	COG2197	response regulator
E4U69_RS21400	COG3539	Fimbrial protein
E4U69_RS21405	COG3539	Fimbrial protein
E4U69_RS21410	COG3188	usher protein
E4U69_RS21415	COG3121	Chaperone
E4U69_RS21420	COG3539	Fimbrial protein
E4U69_RS21430	COG2501	S4 domain
E4U69_RS21435	COG1988	membrane-bound metal-dependent
E4U69_RS21445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4U69_RS21455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4U69_RS21460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4U69_RS21465	COG0549	Belongs to the carbamate kinase family
E4U69_RS21475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U69_RS21480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U69_RS21485	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4U69_RS21490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4U69_RS21495	COG3257	ureidoglycine aminohydrolase activity
E4U69_RS21500	COG1929	Belongs to the glycerate kinase type-1 family
E4U69_RS21505	COG2233	PERMEase
E4U69_RS21515	COG1953	Uracil, thiamine, allantoin
E4U69_RS21520	COG2084	Dehydrogenase
E4U69_RS21525	COG3622	Belongs to the hyi family
E4U69_RS21530	COG3960	tartronate-semialdehyde synthase activity
E4U69_RS21535	COG1414	Transcriptional regulator
E4U69_RS21545	COG0583	DNA-binding transcription factor activity
E4U69_RS21565	COG3209	COG3209 Rhs family protein
E4U69_RS21570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4U69_RS21575	COG4181	ATPase activity
E4U69_RS21580	COG2755	lipolytic protein G-D-S-L family
E4U69_RS21585	COG0300	oxidoreductase activity
E4U69_RS21590	COG3118	belongs to the thioredoxin family
E4U69_RS21595	COG0390	transport system, permease component
E4U69_RS21600	COG4619	ABC transporter
E4U69_RS21605	COG0330	HflC and HflK could
E4U69_RS21610	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4U69_RS21630	COG0789	Transcriptional regulator
E4U69_RS21655	COG0531	amino acid
E4U69_RS21660	COG2066	Belongs to the glutaminase family
E4U69_RS21665	COG2217	Heavy metal translocating P-type atpase
E4U69_RS21670	COG3093	addiction module antidote protein HigA
E4U69_RS21675	COG3735	TraB family
E4U69_RS21680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4U69_RS21685	COG0737	Belongs to the 5'-nucleotidase family
E4U69_RS21690	COG2223	nitrite transmembrane transporter activity
E4U69_RS21695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4U69_RS21695	COG4651	solute:proton antiporter activity
E4U69_RS21700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS21735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4U69_RS21745	COG2832	Protein of unknown function (DUF454)
E4U69_RS21750	COG3923	Primosomal replication protein n
E4U69_RS21760	COG3264	Mechanosensitive ion channel
E4U69_RS21760	COG1196	nuclear chromosome segregation
E4U69_RS21765	COG1309	transcriptional regulator
E4U69_RS21770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U69_RS21775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U69_RS21790	COG0110	maltose O-acetyltransferase activity
E4U69_RS21800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4U69_RS21805	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4U69_RS21815	COG3695	enzyme binding
E4U69_RS21820	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E4U69_RS21825	COG1946	Acyl-CoA thioesterase
E4U69_RS21830	COG0004	ammonium transporteR
E4U69_RS21835	COG0347	Belongs to the P(II) protein family
E4U69_RS21840	COG1132	(ABC) transporter
E4U69_RS21845	COG1132	(ABC) transporter
E4U69_RS21850	COG1522	sequence-specific DNA binding
E4U69_RS21860	COG4533	DNA binding
E4U69_RS21870	COG0824	Thioesterase
E4U69_RS21875	COG1555	photosystem II stabilization
E4U69_RS21880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U69_RS21885	COG0776	regulation of translation
E4U69_RS21890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4U69_RS21910	COG0271	Belongs to the BolA IbaG family
E4U69_RS21915	COG3056	Lipoprotein
E4U69_RS21920	COG2223	nitrite transmembrane transporter activity
E4U69_RS21925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4U69_RS21930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4U69_RS21935	COG1845	cytochrome c oxidase, subunit III
E4U69_RS21940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4U69_RS21950	COG2814	Major facilitator Superfamily
E4U69_RS21960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4U69_RS21965	COG0693	protein deglycase activity
E4U69_RS21980	COG0142	geranyltranstransferase activity
E4U69_RS21990	COG0667	Aldo Keto reductase
E4U69_RS22000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4U69_RS22005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4U69_RS22020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4U69_RS22020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4U69_RS22030	COG4238	major outer membrane lipoprotein
E4U69_RS22035	COG3248	Nucleoside-binding outer membrane protein
E4U69_RS22040	COG1403	HNH endonuclease
E4U69_RS22050	COG3609	addiction module antidote protein, CC2985 family
E4U69_RS22055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4U69_RS22060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4U69_RS22065	COG1862	Preprotein translocase
E4U69_RS22090	COG0366	Alpha amylase catalytic
E4U69_RS22095	COG1113	amino acid transport
E4U69_RS22100	COG1114	Component of the transport system for branched-chain amino acids
E4U69_RS22105	COG5002	protein histidine kinase activity
E4U69_RS22110	COG0745	RESPONSE REGULATOR receiver
E4U69_RS22115	COG0420	3'-5' exonuclease activity
E4U69_RS22120	COG0419	ATPase involved in DNA repair
E4U69_RS22125	COG2814	Major facilitator Superfamily
E4U69_RS22130	COG1940	carbohydrate kinase activity
E4U69_RS22155	COG4126	flavin adenine dinucleotide binding
E4U69_RS22175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4U69_RS22180	COG3706	GGDEF domain
E4U69_RS22190	COG1785	Belongs to the alkaline phosphatase family
E4U69_RS22205	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4U69_RS22225	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4U69_RS22230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U69_RS22235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U69_RS22240	COG3468	outer membrane autotransporter barrel domain protein
E4U69_RS22245	COG0113	porphobilinogen synthase activity
E4U69_RS22250	COG2175	clavaminate synthase activity
E4U69_RS22255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4U69_RS22260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4U69_RS22265	COG4521	taurine ABC transporter
E4U69_RS22280	COG2271	Major facilitator Superfamily
E4U69_RS22285	COG1840	ABC-type Fe3 transport system, periplasmic component
E4U69_RS22295	COG3842	ATPase activity
E4U69_RS22310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4U69_RS22315	COG3122	Protein conserved in bacteria
E4U69_RS22320	COG2814	Major facilitator Superfamily
E4U69_RS22325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4U69_RS22340	COG0596	Alpha beta hydrolase
E4U69_RS22355	COG1414	Transcriptional regulator
E4U69_RS22360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4U69_RS22370	COG1609	Transcriptional regulator
E4U69_RS22375	COG3250	beta-galactosidase activity
E4U69_RS22380	COG2223	nitrite transmembrane transporter activity
E4U69_RS22385	COG0110	maltose O-acetyltransferase activity
E4U69_RS22390	COG2807	transmembrane transport
E4U69_RS22400	COG0288	reversible hydration of carbon dioxide
E4U69_RS22405	COG0583	DNA-binding transcription factor activity
E4U69_RS22410	COG0402	S-adenosylhomocysteine deaminase activity
E4U69_RS22415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4U69_RS22420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4U69_RS22425	COG2079	MmgE PrpD family protein
E4U69_RS22430	COG0372	Belongs to the citrate synthase family
E4U69_RS22435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4U69_RS22440	COG3829	transcription factor binding
E4U69_RS22450	COG1280	lysine exporter protein (LysE YggA)
E4U69_RS22465	COG1064	alcohol dehydrogenase
E4U69_RS22475	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS22485	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS22495	COG0402	S-adenosylhomocysteine deaminase activity
E4U69_RS22500	COG0549	Belongs to the carbamate kinase family
E4U69_RS22510	COG1304	FMN binding
E4U69_RS22515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U69_RS22525	COG0666	response to abiotic stimulus
E4U69_RS22540	COG2771	luxR family
E4U69_RS22540	COG2200	EAL domain
E4U69_RS22550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4U69_RS22585	COG2771	luxR family
E4U69_RS22585	COG2200	EAL domain
E4U69_RS22620	COG1556	Lactate utilization protein
E4U69_RS22625	COG1139	Iron-sulfur cluster binding protein
E4U69_RS22630	COG0247	lactate metabolic process
E4U69_RS22635	COG2207	Transcriptional regulator
E4U69_RS22640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U69_RS22650	COG3059	membrane
E4U69_RS22670	COG3708	Transcriptional regulator
E4U69_RS22670	COG2207	Transcriptional regulator
E4U69_RS22675	COG1388	LysM domain
E4U69_RS22690	COG0583	DNA-binding transcription factor activity
E4U69_RS22695	COG1073	alpha beta
E4U69_RS22700	COG1902	pentaerythritol trinitrate reductase activity
E4U69_RS22710	COG4372	Transposase
E4U69_RS22715	COG3436	PFAM IS66 Orf2 family protein
E4U69_RS22755	COG3188	usher protein
E4U69_RS22765	COG3121	Chaperone
E4U69_RS22770	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4U69_RS22775	COG3477	response to acidic pH
E4U69_RS22780	COG2080	2 iron, 2 sulfur cluster binding
E4U69_RS22785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U69_RS22790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U69_RS22795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4U69_RS22810	COG0583	DNA-binding transcription factor activity
E4U69_RS22820	COG4221	oxidoreductase activity
E4U69_RS22835	COG0583	DNA-binding transcription factor activity
E4U69_RS22915	COG0582	viral genome integration into host DNA
E4U69_RS22935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U69_RS22945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U69_RS23035	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4U69_RS23040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4U69_RS23045	COG1690	Belongs to the RtcB family
E4U69_RS23050	COG0454	-acetyltransferase
E4U69_RS23060	COG2161	toxin-antitoxin pair type II binding
E4U69_RS23065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4U69_RS23085	COG0791	NLP P60 protein
E4U69_RS23090	COG3077	Addiction module antitoxin, RelB DinJ family
E4U69_RS23095	COG3041	Addiction module toxin RelE StbE family
E4U69_RS23100	COG3034	peptidoglycan biosynthetic process
E4U69_RS23105	COG0121	glutamine amidotransferase
E4U69_RS23115	COG1960	acyl-CoA dehydrogenase activity
E4U69_RS23125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U69_RS23130	COG5433	transposase activity
E4U69_RS23145	COG3209	COG3209 Rhs family protein
E4U69_RS23150	COG5433	transposase activity
E4U69_RS23160	COG3209	COG3209 Rhs family protein
E4U69_RS23165	COG3501	Rhs element vgr protein
E4U69_RS23280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U69_RS23290	COG2226	methyltransferase
E4U69_RS23300	COG1388	LysM domain
E4U69_RS23300	COG0741	lytic transglycosylase activity
E4U69_RS23305	COG2226	methyltransferase
E4U69_RS23315	COG0583	DNA-binding transcription factor activity
E4U69_RS23320	COG0656	L-ascorbic acid biosynthetic process
E4U69_RS23355	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4U69_RS23360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4U69_RS23365	COG2011	ABC-type metal ion transport system permease component
E4U69_RS23370	COG1464	Belongs to the NlpA lipoprotein family
E4U69_RS23380	COG1720	tRNA m6t6A37 methyltransferase activity
E4U69_RS23390	COG0791	NLP P60 protein
E4U69_RS23395	COG3015	lipoprotein NlpE involved in copper resistance
E4U69_RS23400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4U69_RS23405	COG4681	YaeQ
E4U69_RS23415	COG4568	rho-dependent transcription termination
E4U69_RS23420	COG0037	tRNA processing
E4U69_RS23425	COG0346	lactoylglutathione lyase activity
E4U69_RS23440	COG0587	DNA-directed DNA polymerase activity
E4U69_RS23465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4U69_RS23470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E4U69_RS23480	COG0750	zinc metalloprotease
E4U69_RS23485	COG0575	Belongs to the CDS family
E4U69_RS23490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4U69_RS23495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4U69_RS23520	COG0024	Methionine aminopeptidase
E4U69_RS23540	COG3835	regulator
E4U69_RS23545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U69_RS23560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4U69_RS23565	COG2860	membrane
E4U69_RS23590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U69_RS23595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4U69_RS23600	COG1120	ATPase activity
E4U69_RS23605	COG4774	siderophore transport
E4U69_RS23610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4U69_RS23615	COG1643	Atp-dependent helicase
E4U69_RS23620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4U69_RS23630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4U69_RS23635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4U69_RS23640	COG0617	tRNA 3'-terminal CCA addition
E4U69_RS23645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4U69_RS23655	COG3121	Chaperone
E4U69_RS23660	COG3188	usher protein
E4U69_RS23665	COG3539	Fimbrial protein
E4U69_RS23670	COG3539	Fimbrial protein
E4U69_RS23695	COG5464	transposase or invertase
E4U69_RS23705	COG0726	polysaccharide deacetylase
E4U69_RS23710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS23715	COG0842	Transport permease protein
E4U69_RS23720	COG1131	(ABC) transporter
E4U69_RS23725	COG0288	reversible hydration of carbon dioxide
E4U69_RS23730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4U69_RS23735	COG4993	Dehydrogenase
E4U69_RS23740	COG2132	Multicopper oxidase
E4U69_RS23765	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4U69_RS23770	COG3064	Membrane
E4U69_RS23775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U69_RS23780	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4U69_RS23785	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4U69_RS23790	COG2186	Transcriptional regulator
E4U69_RS23795	COG1113	amino acid transport
E4U69_RS23800	COG3725	Membrane protein required for beta-lactamase induction
E4U69_RS23805	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4U69_RS23810	COG0157	Belongs to the NadC ModD family
E4U69_RS23815	COG4969	Belongs to the N-Me-Phe pilin family
E4U69_RS23820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4U69_RS23825	COG1459	type II secretion system
E4U69_RS23835	COG0237	dephospho-CoA kinase activity
E4U69_RS23850	COG0494	nUDIX hydrolase
E4U69_RS23870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4U69_RS23875	COG0849	cell division
E4U69_RS23880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4U69_RS23885	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4U69_RS23900	COG0772	Belongs to the SEDS family
E4U69_RS23905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4U69_RS23915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4U69_RS23920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4U69_RS23925	COG0768	penicillin binding
E4U69_RS23930	COG3116	cell division
E4U69_RS23945	COG1609	Transcriptional regulator
E4U69_RS23955	COG0440	acetolactate synthase activity
E4U69_RS23960	COG0028	Belongs to the TPP enzyme family
E4U69_RS23965	COG0583	DNA-binding transcription factor activity
E4U69_RS23980	COG0473	3-isopropylmalate dehydrogenase activity
E4U69_RS24000	COG4533	DNA binding
E4U69_RS24010	COG4143	(ABC) transporter
E4U69_RS24015	COG1178	ABC-type Fe3 transport system permease component
E4U69_RS24020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4U69_RS24025	COG0586	Pfam SNARE associated Golgi protein
E4U69_RS24030	COG4977	sequence-specific DNA binding
E4U69_RS24045	COG0235	Class ii aldolase
E4U69_RS24050	COG0417	DNA replication proofreading
E4U69_RS24060	COG0564	pseudouridine synthase activity
E4U69_RS24070	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U69_RS24075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4U69_RS24080	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U69_RS24085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U69_RS24120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4U69_RS24135	COG2271	Major facilitator Superfamily
E4U69_RS24140	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U69_RS24145	COG0644	oxidoreductase
E4U69_RS24180	COG1024	Enoyl-CoA hydratase
E4U69_RS24195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4U69_RS24200	COG0505	Belongs to the CarA family
E4U69_RS24220	COG1047	Peptidyl-prolyl cis-trans
E4U69_RS24235	COG0196	riboflavin kinase activity
E4U69_RS24260	COG3121	Chaperone
E4U69_RS24265	COG3188	usher protein
E4U69_RS24275	COG0583	DNA-binding transcription factor activity
E4U69_RS24305	COG4735	regulation of single-species biofilm formation
E4U69_RS24310	COG1584	GPR1 FUN34 yaaH family protein
E4U69_RS24315	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4U69_RS24320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U69_RS24325	COG1115	amino acid carrier protein
E4U69_RS24340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4U69_RS24350	COG0460	homoserine dehydrogenase
E4U69_RS24350	COG0527	aspartate kinase activity
E4U69_RS24360	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4U69_RS24370	COG0745	RESPONSE REGULATOR receiver
E4U69_RS24375	COG4452	Inner membrane protein CreD
E4U69_RS24380	COG2205	protein histidine kinase activity
E4U69_RS24385	COG0745	RESPONSE REGULATOR receiver
E4U69_RS24390	COG3045	CreA protein
E4U69_RS24395	COG3708	Transcriptional regulator
E4U69_RS24395	COG2207	Transcriptional regulator
E4U69_RS24405	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E4U69_RS24415	COG0741	lytic transglycosylase activity
E4U69_RS24420	COG0488	(ABC) transporter
E4U69_RS24430	COG3172	ATPase kinase involved in NAD metabolism
E4U69_RS24430	COG1056	cytidyltransferase-related domain
E4U69_RS24435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4U69_RS24440	COG0560	Phosphoserine phosphatase
E4U69_RS24450	COG0095	Lipoate-protein ligase
E4U69_RS24450	COG3726	membrane protein affecting hemolysin expression
E4U69_RS24485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U69_RS24490	COG0084	hydrolase, TatD family'
E4U69_RS24495	COG4667	esterase of the alpha-beta hydrolase superfamily
E4U69_RS24505	COG2823	Periplasmic or secreted lipoprotein
E4U69_RS24515	COG1011	Hydrolase
E4U69_RS24520	COG0456	acetyltransferase
E4U69_RS24525	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E4U69_RS24545	COG4114	ferric iron reductase
E4U69_RS24550	COG2197	response regulator
E4U69_RS24555	COG2197	response regulator
E4U69_RS24560	COG2966	Psort location CytoplasmicMembrane, score
E4U69_RS24575	COG1484	DNA-dependent DNA replication
E4U69_RS24590	COG1063	alcohol dehydrogenase
E4U69_RS24595	COG1802	Transcriptional regulator
E4U69_RS24600	COG2271	Major facilitator Superfamily
E4U69_RS24605	COG0840	transmembrane signaling receptor activity
E4U69_RS24615	COG1966	Carbon starvation protein
E4U69_RS24620	COG2879	small protein
E4U69_RS24625	COG0523	cobalamin synthesis protein
E4U69_RS24650	COG0732	type I restriction modification DNA specificity domain
E4U69_RS24670	COG5457	Domain of unknown function (DUF1127)
E4U69_RS24675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4U69_RS24685	COG5464	transposase or invertase
E4U69_RS24690	COG2814	Major facilitator Superfamily
E4U69_RS24695	COG2733	membrane
E4U69_RS24700	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4U69_RS24705	COG1924	4 iron, 4 sulfur cluster binding
E4U69_RS24720	COG3204	pilus organization
E4U69_RS24725	COG0477	Major facilitator Superfamily
E4U69_RS24740	COG3366	ferrous iron transmembrane transporter activity
E4U69_RS24745	COG0700	Nucleoside recognition
E4U69_RS24750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U69_RS24775	COG2186	Transcriptional regulator
E4U69_RS24780	COG0246	Mannitol dehydrogenase
E4U69_RS24790	COG2610	gluconate transmembrane transporter activity
E4U69_RS24795	COG3539	Fimbrial protein
E4U69_RS24800	COG3539	Fimbrial protein
E4U69_RS24805	COG3539	Fimbrial protein
E4U69_RS24810	COG3188	usher protein
E4U69_RS24815	COG3121	Chaperone
E4U69_RS24820	COG3539	Fimbrial protein
E4U69_RS24825	COG3539	Fimbrial protein
E4U69_RS24830	COG4974	Belongs to the 'phage' integrase family
E4U69_RS24835	COG0582	viral genome integration into host DNA
E4U69_RS24840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U69_RS24845	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E4U69_RS24860	COG0210	DNA helicase
E4U69_RS24865	COG1205	dead DEAH box helicase
E4U69_RS24865	COG1111	helicase
E4U69_RS24875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U69_RS24920	COG0582	viral genome integration into host DNA
E4U69_RS24975	COG1064	alcohol dehydrogenase
E4U69_RS24980	COG0433	COG0433 Predicted ATPase
E4U69_RS24985	COG0795	lipopolysaccharide-transporting ATPase activity
E4U69_RS24990	COG0795	lipopolysaccharide-transporting ATPase activity
E4U69_RS25000	COG2927	DNA polymerase III (CHI subunit)
E4U69_RS25010	COG4269	membrane
E4U69_RS25015	COG0456	acetyltransferase
E4U69_RS25020	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4U69_RS25025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4U69_RS25035	COG2731	YhcH YjgK YiaL family protein
E4U69_RS25040	COG1309	transcriptional regulator
E4U69_RS25045	COG1028	Short-chain dehydrogenase reductase Sdr
E4U69_RS25050	COG0251	oxidation-reduction process
E4U69_RS25070	COG0251	oxidation-reduction process
E4U69_RS25075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4U69_RS25085	COG1609	Transcriptional regulator
E4U69_RS25090	COG1263	PTS System
E4U69_RS25090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U69_RS25095	COG0366	Alpha amylase catalytic
E4U69_RS25100	COG1328	CTP reductase activity
E4U69_RS25105	COG0602	queuosine metabolic process
E4U69_RS25110	COG3783	Cytochrome b(562)
E4U69_RS25115	COG0312	modulator of DNA gyrase
E4U69_RS25125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4U69_RS25135	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS25140	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS25145	COG1129	ABC transporter
E4U69_RS25150	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS25155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4U69_RS25160	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4U69_RS25165	COG2336	PFAM SpoVT AbrB
E4U69_RS25170	COG2105	PFAM AIG2 family protein
E4U69_RS25175	COG2911	Protein conserved in bacteria
E4U69_RS25180	COG0729	surface antigen
E4U69_RS25190	COG1253	flavin adenine dinucleotide binding
E4U69_RS25200	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4U69_RS25210	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4U69_RS25215	COG0737	Belongs to the 5'-nucleotidase family
E4U69_RS25220	COG1733	regulation of RNA biosynthetic process
E4U69_RS25225	COG0702	epimerase
E4U69_RS25230	COG0697	spore germination
E4U69_RS25240	COG1113	amino acid transport
E4U69_RS25245	COG0545	Peptidyl-prolyl cis-trans isomerase
E4U69_RS25250	COG3061	Opacity-associated protein A
E4U69_RS25260	COG0675	Transposase, IS605 OrfB family
E4U69_RS25285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4U69_RS25320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS25325	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U69_RS25330	COG3037	sugar-specific permease SgaT UlaA
E4U69_RS25345	COG1073	alpha beta
E4U69_RS25350	COG3650	response to hydrogen peroxide
E4U69_RS25360	COG1960	acyl-CoA dehydrogenase activity
E4U69_RS25365	COG0754	glutathionylspermidine amidase activity
E4U69_RS25370	COG5463	Belongs to the UPF0441 family
E4U69_RS25375	COG3766	membrane
E4U69_RS25385	COG1842	Phage shock protein A
E4U69_RS25390	COG3789	protein conserved in bacteria
E4U69_RS25395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U69_RS25400	COG0557	exoribonuclease II activity
E4U69_RS25415	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4U69_RS25420	COG0330	HflC and HflK could
E4U69_RS25425	COG0330	HflC and HflK could
E4U69_RS25430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4U69_RS25445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4U69_RS25450	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U69_RS25455	COG0802	atpase or kinase
E4U69_RS25460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4U69_RS25460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4U69_RS25490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4U69_RS25505	COG3264	Mechanosensitive ion channel
E4U69_RS25505	COG1511	domain protein
E4U69_RS25510	COG0531	amino acid
E4U69_RS25520	COG1053	succinate dehydrogenase
E4U69_RS25525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4U69_RS25540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U69_RS25545	COG3040	lipid binding
E4U69_RS25550	COG2076	Multidrug Resistance protein
E4U69_RS25555	COG5510	response to toxic substance
E4U69_RS25560	COG5510	response to toxic substance
E4U69_RS25570	COG1509	lysine 2,3-aminomutase activity
E4U69_RS25595	COG0531	amino acid
E4U69_RS25600	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4U69_RS25605	COG1027	Aspartate ammonia-lyase
E4U69_RS25610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4U69_RS25620	COG4232	protein-disulfide reductase activity
E4U69_RS25625	COG1309	transcriptional regulator
E4U69_RS25635	COG3710	Transcriptional regulator
E4U69_RS25640	COG0531	amino acid
E4U69_RS25645	COG1982	Orn Lys Arg decarboxylase major
E4U69_RS25650	COG3104	oligopeptide transport
E4U69_RS25655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4U69_RS25670	COG2388	GCN5-related N-acetyl-transferase
E4U69_RS25675	COG3592	Divergent 4Fe-4S mono-cluster
E4U69_RS25680	COG3290	protein histidine kinase activity
E4U69_RS25685	COG4565	transcriptional regulatory protein
E4U69_RS25690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4U69_RS25695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS25695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U69_RS25700	COG3647	Membrane
E4U69_RS25705	COG2211	Major facilitator Superfamily
E4U69_RS25710	COG1486	melibiose metabolic process
E4U69_RS25715	COG2169	Transcriptional regulator
E4U69_RS25720	COG1982	Orn Lys Arg decarboxylase major
E4U69_RS25725	COG2207	Transcriptional regulator
E4U69_RS25730	COG0531	amino acid
E4U69_RS25735	COG2194	sulfuric ester hydrolase activity
E4U69_RS25740	COG0745	RESPONSE REGULATOR receiver
E4U69_RS25745	COG0642	Histidine kinase
E4U69_RS25755	COG0477	Major facilitator Superfamily
E4U69_RS25765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4U69_RS25770	COG2824	Alkylphosphonate utilization operon protein PhnA
E4U69_RS25775	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4U69_RS25785	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4U69_RS25790	COG3639	organic phosphonate transmembrane transporter activity
E4U69_RS25795	COG2188	Transcriptional regulator
E4U69_RS25800	COG3624	Phosphonate C-P lyase system protein PhnG
E4U69_RS25805	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E4U69_RS25810	COG3626	phosphonate metabolism
E4U69_RS25815	COG3627	carbon phosphorus lyase activity
E4U69_RS25820	COG4107	phosphonate C-P lyase system protein PhnK
E4U69_RS25825	COG4778	phosphonate C-P lyase system protein PhnL
E4U69_RS25830	COG3454	Phosphonate metabolism
E4U69_RS25835	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4U69_RS25840	COG0456	acetyltransferase
E4U69_RS25845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4U69_RS25860	COG1129	ABC transporter
E4U69_RS25865	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS25885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS25895	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4U69_RS25905	COG1566	PFAM secretion protein HlyD family protein
E4U69_RS25910	COG1289	transmembrane transporter activity
E4U69_RS25915	COG1538	Outer membrane efflux protein
E4U69_RS25925	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U69_RS25930	COG1301	dicarboxylic acid transport
E4U69_RS25935	COG4235	cytochrome complex assembly
E4U69_RS25940	COG3088	subunit of a heme lyase
E4U69_RS25945	COG1138	Cytochrome C-type biogenesis protein
E4U69_RS25950	COG3301	Polysulphide reductase, NrfD
E4U69_RS25955	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS25960	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4U69_RS25970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4U69_RS25975	COG3162	membrane
E4U69_RS25985	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U69_RS25990	COG0025	NhaP-type Na H and K H
E4U69_RS25995	COG2252	PERMEase
E4U69_RS26000	COG0789	Transcriptional regulator
E4U69_RS26005	COG2207	Transcriptional regulator
E4U69_RS26010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4U69_RS26020	COG0629	single-stranded DNA binding
E4U69_RS26025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4U69_RS26030	COG2315	Protein conserved in bacteria
E4U69_RS26035	COG0432	Pfam Uncharacterised protein family UPF0047
E4U69_RS26040	COG3700	Belongs to the class B bacterial acid phosphatase family
E4U69_RS26050	COG1448	Aminotransferase
E4U69_RS26055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4U69_RS26060	COG0305	Participates in initiation and elongation during chromosome replication
E4U69_RS26065	COG0604	alcohol dehydrogenase
E4U69_RS26075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U69_RS26115	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U69_RS26135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4U69_RS26175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U69_RS26185	COG0735	belongs to the Fur family
E4U69_RS26190	COG3237	CsbD-like
E4U69_RS26195	COG0534	Mate efflux family protein
E4U69_RS26205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4U69_RS26225	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U69_RS26240	COG3842	ATPase activity
E4U69_RS26245	COG2182	Extracellular solute-binding protein
E4U69_RS26250	COG1175	transmembrane transport
E4U69_RS26255	COG3833	ABC-type maltose transport systems, permease component
E4U69_RS26260	COG0477	Major facilitator Superfamily
E4U69_RS26260	COG2814	Major facilitator Superfamily
E4U69_RS26280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U69_RS26305	COG0527	aspartate kinase activity
E4U69_RS26315	COG1187	pseudouridine synthase activity
E4U69_RS26360	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4U69_RS26365	COG1410	methionine synthase
E4U69_RS26365	COG0646	methionine synthase
E4U69_RS26370	COG1414	Transcriptional regulator
E4U69_RS26385	COG2224	Isocitrate lyase
E4U69_RS26390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4U69_RS26400	COG0456	acetyltransferase
E4U69_RS26430	COG0151	Belongs to the GarS family
E4U69_RS26435	COG2204	response regulator
E4U69_RS26440	COG4191	Histidine kinase
E4U69_RS26445	COG3678	ATP-independent chaperone mediated protein folding
E4U69_RS26460	COG3068	Protein conserved in bacteria
E4U69_RS26495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4U69_RS26500	COG2104	thiamine diphosphate biosynthetic process
E4U69_RS26505	COG2022	thiamine diphosphate biosynthetic process
E4U69_RS26510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4U69_RS26550	COG0250	Participates in transcription elongation, termination and antitermination
E4U69_RS26555	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4U69_RS26590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4U69_RS26590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4U69_RS26595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4U69_RS26620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4U69_RS26625	COG4206	TonB-dependent receptor
E4U69_RS26630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4U69_RS26640	COG1309	transcriptional regulator
E4U69_RS26645	COG0477	Major facilitator Superfamily
E4U69_RS26650	COG1473	amidohydrolase
E4U69_RS26655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U69_RS26660	COG0583	DNA-binding transcription factor activity
E4U69_RS26675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4U69_RS26690	COG2194	sulfuric ester hydrolase activity
E4U69_RS26695	COG2207	Transcriptional regulator
E4U69_RS26700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS26705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U69_RS26710	COG1882	Formate acetyltransferase
E4U69_RS26715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS26720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS26725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U69_RS26725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS26725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS26730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U69_RS26735	COG0371	Dehydrogenase
E4U69_RS26740	COG3738	Protein conserved in bacteria
E4U69_RS26745	COG0697	spore germination
E4U69_RS26755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4U69_RS26760	COG0460	homoserine dehydrogenase
E4U69_RS26760	COG0527	aspartate kinase activity
E4U69_RS26765	COG0626	cystathionine gamma-synthase activity
E4U69_RS26775	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E4U69_RS26790	COG3209	COG3209 Rhs family protein
E4U69_RS26800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4U69_RS26805	COG1609	Transcriptional regulator
E4U69_RS26810	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4U69_RS26825	COG1575	Belongs to the MenA family. Type 1 subfamily
E4U69_RS26850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4U69_RS26860	COG1494	fructose-1,6-bisphosphatase
E4U69_RS26870	COG0589	response to stress
E4U69_RS26875	COG3691	Protein conserved in bacteria
E4U69_RS26880	COG3152	Membrane
E4U69_RS26900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4U69_RS26915	COG3678	ATP-independent chaperone mediated protein folding
E4U69_RS26920	COG0745	RESPONSE REGULATOR receiver
E4U69_RS26925	COG2205	protein histidine kinase activity
E4U69_RS26930	COG2258	MOSC domain
E4U69_RS26940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4U69_RS26950	COG4977	sequence-specific DNA binding
E4U69_RS26950	COG1917	Cupin 2, conserved barrel domain protein
E4U69_RS26985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS26990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS26990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U69_RS26995	COG1363	Peptidase, m42
E4U69_RS27000	COG3711	transcriptional antiterminator
E4U69_RS27000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U69_RS27020	COG0437	4 iron, 4 sulfur cluster binding
E4U69_RS27025	COG2864	formate dehydrogenase
E4U69_RS27035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U69_RS27040	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U69_RS27055	COG0456	acetyltransferase
E4U69_RS27070	COG1011	Hydrolase
E4U69_RS27075	COG1349	DNA-binding transcription factor activity
E4U69_RS27080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS27085	COG2084	Dehydrogenase
E4U69_RS27090	COG3684	Belongs to the aldolase LacD family
E4U69_RS27095	COG2942	2-epimerase
E4U69_RS27100	COG2017	converts alpha-aldose to the beta-anomer
E4U69_RS27110	COG1501	Belongs to the glycosyl hydrolase 31 family
E4U69_RS27115	COG2211	Major facilitator Superfamily
E4U69_RS27120	COG2211	Major facilitator Superfamily
E4U69_RS27125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U69_RS27130	COG2271	Major facilitator Superfamily
E4U69_RS27135	COG1082	Xylose isomerase domain protein TIM barrel
E4U69_RS27140	COG2188	Transcriptional regulator
E4U69_RS27150	COG0174	glutamine synthetase
E4U69_RS27155	COG3852	Histidine kinase
E4U69_RS27160	COG2204	response regulator
E4U69_RS27170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4U69_RS27175	COG3078	GTPase activator activity
E4U69_RS27185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4U69_RS27185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4U69_RS27190	COG0204	Acyl-transferase
E4U69_RS27195	COG5339	Protein conserved in bacteria
E4U69_RS27200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U69_RS27205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4U69_RS27210	COG3084	Protein conserved in bacteria
E4U69_RS27215	COG0746	molybdenum cofactor guanylyltransferase activity
E4U69_RS27220	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4U69_RS27250	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4U69_RS27255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4U69_RS27260	COG1739	Uncharacterized protein family UPF0029
E4U69_RS27275	COG0183	Belongs to the thiolase family
E4U69_RS27280	COG0543	2 iron, 2 sulfur cluster binding
E4U69_RS27285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4U69_RS27290	COG0250	Participates in transcription elongation, termination and antitermination
E4U69_RS27295	COG0084	hydrolase, TatD family'
E4U69_RS27300	COG0805	protein transport
E4U69_RS27305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U69_RS27310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U69_RS27320	COG3165	ubiquinone biosynthetic process from chorismate
E4U69_RS27330	COG1322	Protein conserved in bacteria
E4U69_RS27335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4U69_RS27340	COG0412	Dienelactone hydrolase
E4U69_RS27345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4U69_RS27350	COG0583	DNA-binding transcription factor activity
E4U69_RS27355	COG0697	spore germination
E4U69_RS27360	COG0561	phosphatase activity
E4U69_RS27365	COG2267	carboxylic ester hydrolase activity
E4U69_RS27370	COG1280	lysine exporter protein (LysE YggA)
E4U69_RS27375	COG1280	lysine exporter protein (LysE YggA)
E4U69_RS27380	COG0514	ATP-dependent DNA helicase (RecQ)
E4U69_RS27385	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E4U69_RS27390	COG2050	protein possibly involved in aromatic compounds catabolism
E4U69_RS27395	COG2962	Rard protein
E4U69_RS27420	COG0598	Magnesium transport protein CorA
E4U69_RS27425	COG3698	Phosphodiester glycosidase
E4U69_RS27430	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4U69_RS27435	COG0210	DNA helicase
E4U69_RS27440	COG1011	Hydrolase
E4U69_RS27450	COG3159	Protein conserved in bacteria
E4U69_RS27460	COG5567	small periplasmic lipoprotein
E4U69_RS27470	COG3072	Adenylate cyclase
E4U69_RS27480	COG1587	Uroporphyrinogen-III synthase
E4U69_RS27485	COG2959	enzyme of heme biosynthesis
E4U69_RS27490	COG3071	HemY protein
E4U69_RS27495	COG3119	arylsulfatase activity
E4U69_RS27500	COG0641	radical SAM
E4U69_RS27530	COG1113	amino acid transport
E4U69_RS27545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4U69_RS27550	COG2244	polysaccharide biosynthetic process
E4U69_RS27555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4U69_RS27560	COG0456	acetyltransferase
E4U69_RS27565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4U69_RS27570	COG1088	dTDP-glucose 4,6-dehydratase activity
E4U69_RS27575	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4U69_RS27580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4U69_RS27585	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4U69_RS27590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4U69_RS27595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4U69_RS27605	COG3118	belongs to the thioredoxin family
E4U69_RS27620	COG0210	DNA helicase
E4U69_RS27625	COG3692	DNA binding
E4U69_RS27630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U69_RS27640	COG0583	DNA-binding transcription factor activity
E4U69_RS27645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U69_RS27655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4U69_RS27660	COG3978	acetolactate synthase activity
E4U69_RS27680	COG0606	chelatase, subunit chli
E4U69_RS27685	COG3085	chromosome segregation
E4U69_RS27725	COG2186	Transcriptional regulator
E4U69_RS27730	COG0477	Major facilitator Superfamily
E4U69_RS27735	COG1609	Transcriptional regulator
E4U69_RS27740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U69_RS27745	COG1879	ABC-type sugar transport system periplasmic component
E4U69_RS27750	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U69_RS27755	COG1129	ABC transporter
E4U69_RS27765	COG3158	transport of potassium into the cell
E4U69_RS27785	COG1522	sequence-specific DNA binding
E4U69_RS27790	COG0716	FMN binding
E4U69_RS27880	COG2274	protein secretion by the type I secretion system
E4U69_RS28050	COG1475	DNA binding
E4U69_RS28135	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4U69_RS28145	COG1525	nuclease
E4U69_RS28225	COG3468	outer membrane autotransporter barrel domain protein
E4U69_RS28235	COG0726	polysaccharide deacetylase
E4U69_RS28240	COG0297	glycogen (starch) synthase activity
E4U69_RS28245	COG2194	sulfuric ester hydrolase activity
E4U69_RS28250	COG1560	Kdo2-lipid A biosynthetic process