locus-tag	class	description
E4U63_RS00015	COG3312	ion transport
E4U63_RS00065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4U63_RS00090	COG3539	Fimbrial protein
E4U63_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4U63_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E4U63_RS00110	COG0581	inorganic phosphate transmembrane transporter activity
E4U63_RS00115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4U63_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
E4U63_RS00145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U63_RS00150	COG2252	PERMEase
E4U63_RS00155	COG0431	NADPH-dependent FMN reductase
E4U63_RS00160	COG2091	lysine biosynthetic process via aminoadipic acid
E4U63_RS00175	COG0814	amino acid
E4U63_RS00230	COG0592	DNA-directed DNA polymerase activity
E4U63_RS00240	COG0187	DNA topoisomerase II activity
E4U63_RS00245	COG3753	Protein conserved in bacteria
E4U63_RS00250	COG0561	phosphatase activity
E4U63_RS00260	COG0644	oxidoreductase
E4U63_RS00265	COG0823	Involved in the tonB-independent uptake of proteins
E4U63_RS00270	COG5645	(Lipo)protein
E4U63_RS00290	COG2188	Transcriptional regulator
E4U63_RS00305	COG2207	Transcriptional regulator
E4U63_RS00310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4U63_RS00315	COG3119	arylsulfatase activity
E4U63_RS00325	COG2149	membrane
E4U63_RS00335	COG0641	radical SAM
E4U63_RS00340	COG2814	Major facilitator Superfamily
E4U63_RS00355	COG0028	Belongs to the TPP enzyme family
E4U63_RS00360	COG0440	acetolactate synthase activity
E4U63_RS00380	COG2197	response regulator
E4U63_RS00385	COG3851	Histidine kinase
E4U63_RS00390	COG2271	Major facilitator Superfamily
E4U63_RS00395	COG2271	Major facilitator Superfamily
E4U63_RS00425	COG2814	Major facilitator Superfamily
E4U63_RS00435	COG1464	Belongs to the NlpA lipoprotein family
E4U63_RS00440	COG0697	spore germination
E4U63_RS00445	COG2814	Major facilitator Superfamily
E4U63_RS00610	COG5492	domain, Protein
E4U63_RS00665	COG4372	Transposase
E4U63_RS00670	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS00715	COG0582	viral genome integration into host DNA
E4U63_RS00725	COG2211	Major facilitator Superfamily
E4U63_RS00730	COG1501	Belongs to the glycosyl hydrolase 31 family
E4U63_RS00735	COG2982	Protein involved in outer membrane biogenesis
E4U63_RS00740	COG2233	PERMEase
E4U63_RS00745	COG0786	glutamate:sodium symporter activity
E4U63_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4U63_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U63_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4U63_RS00775	COG0194	GDP metabolic process
E4U63_RS00785	COG2860	membrane
E4U63_RS00790	COG3645	SOS response
E4U63_RS00795	COG1561	YicC-like family, N-terminal region
E4U63_RS00820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4U63_RS00850	COG1519	Transferase
E4U63_RS00855	COG0859	PFAM glycosyl transferase family 9
E4U63_RS00860	COG0438	transferase activity, transferring glycosyl groups
E4U63_RS00865	COG0515	serine threonine protein kinase
E4U63_RS00875	COG3642	lipopolysaccharide core region biosynthetic process
E4U63_RS00895	COG0859	PFAM glycosyl transferase family 9
E4U63_RS00900	COG0859	PFAM glycosyl transferase family 9
E4U63_RS00915	COG0156	8-amino-7-oxononanoate synthase activity
E4U63_RS00925	COG1216	Glycosyl transferase, family 2
E4U63_RS00930	COG2861	carbohydrate metabolic process
E4U63_RS00935	COG4942	peptidase
E4U63_RS00945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U63_RS00950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U63_RS00965	COG1045	serine acetyltransferase
E4U63_RS00970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4U63_RS00980	COG2186	Transcriptional regulator
E4U63_RS00985	COG1620	l-lactate permease
E4U63_RS00990	COG5295	Hep Hag repeat protein
E4U63_RS01010	COG3722	fumarate hydratase activity
E4U63_RS01020	COG2213	PTS system mannitol-specific
E4U63_RS01020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS01030	COG1566	PFAM secretion protein HlyD family protein
E4U63_RS01040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U63_RS01045	COG3209	COG3209 Rhs family protein
E4U63_RS01050	COG0625	glutathione transferase activity
E4U63_RS01060	COG3276	selenocysteine insertion sequence binding
E4U63_RS01065	COG1454	alcohol dehydrogenase
E4U63_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS01085	COG1566	PFAM secretion protein HlyD family protein
E4U63_RS01090	COG0583	DNA-binding transcription factor activity
E4U63_RS01095	COG3713	MltA-interacting MipA family protein
E4U63_RS01105	COG2211	Major facilitator Superfamily
E4U63_RS01115	COG1414	Transcriptional regulator
E4U63_RS01120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS01125	COG3977	Valine--pyruvate aminotransferase
E4U63_RS01130	COG0366	Alpha amylase catalytic
E4U63_RS01135	COG2992	FlgJ-related protein
E4U63_RS01140	COG1609	Transcriptional regulator
E4U63_RS01140	COG2207	Transcriptional regulator
E4U63_RS01145	COG4214	carbohydrate transport
E4U63_RS01155	COG4213	ABC transporter substrate-binding protein
E4U63_RS01165	COG1070	Carbohydrate kinase
E4U63_RS01170	COG4682	membrane
E4U63_RS01175	COG4682	membrane
E4U63_RS01180	COG3274	enterobacterial common antigen metabolic process
E4U63_RS01205	COG1278	Cold shock
E4U63_RS01210	COG2944	sequence-specific DNA binding
E4U63_RS01225	COG2885	chlorophyll binding
E4U63_RS01230	COG0243	molybdopterin cofactor binding
E4U63_RS01235	COG0456	acetyltransferase
E4U63_RS01240	COG2818	Glycosylase
E4U63_RS01245	COG5571	outer membrane autotransporter
E4U63_RS01250	COG2223	nitrite transmembrane transporter activity
E4U63_RS01255	COG3539	Fimbrial protein
E4U63_RS01260	COG3121	Chaperone
E4U63_RS01270	COG3539	Fimbrial protein
E4U63_RS01275	COG3539	Fimbrial protein
E4U63_RS01280	COG2194	sulfuric ester hydrolase activity
E4U63_RS01290	COG0747	negative chemotaxis
E4U63_RS01295	COG0601	transmembrane transport
E4U63_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U63_RS01305	COG0444	Belongs to the ABC transporter superfamily
E4U63_RS01310	COG4608	Belongs to the ABC transporter superfamily
E4U63_RS01315	COG0814	amino acid
E4U63_RS01325	COG2194	sulfuric ester hydrolase activity
E4U63_RS01355	COG1215	transferase activity, transferring glycosyl groups
E4U63_RS01360	COG1215	transferase activity, transferring glycosyl groups
E4U63_RS01365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4U63_RS01370	COG3118	belongs to the thioredoxin family
E4U63_RS01370	COG0457	Tetratricopeptide repeat
E4U63_RS01375	COG2199	diguanylate cyclase activity
E4U63_RS01375	COG2200	EAL domain
E4U63_RS01385	COG0612	Peptidase, M16
E4U63_RS01395	COG2200	EAL domain
E4U63_RS01400	COG2982	Protein involved in outer membrane biogenesis
E4U63_RS01405	COG0477	Major facilitator Superfamily
E4U63_RS01410	COG1295	ribonuclease BN
E4U63_RS01415	COG0583	DNA-binding transcription factor activity
E4U63_RS01420	COG2197	response regulator
E4U63_RS01430	COG1858	cytochrome C peroxidase
E4U63_RS01435	COG0076	glutamate decarboxylase activity
E4U63_RS01440	COG2207	Transcriptional regulator
E4U63_RS01445	COG2207	Transcriptional regulator
E4U63_RS01450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U63_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS01465	COG2771	luxR family
E4U63_RS01470	COG3247	response to pH
E4U63_RS01485	COG1285	pathogenesis
E4U63_RS01490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4U63_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U63_RS01505	COG3721	Heme iron utilization protein
E4U63_RS01515	COG4558	Periplasmic binding protein
E4U63_RS01525	COG4771	TonB-dependent receptor
E4U63_RS01530	COG3720	iron ion transport
E4U63_RS01535	COG2197	response regulator
E4U63_RS01540	COG3065	identical protein binding
E4U63_RS01550	COG1393	Belongs to the ArsC family
E4U63_RS01555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4U63_RS01560	COG0640	Transcriptional regulator
E4U63_RS01570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U63_RS01575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4U63_RS01580	COG0339	signal peptide processing
E4U63_RS01590	COG3104	oligopeptide transport
E4U63_RS01595	COG0589	response to stress
E4U63_RS01605	COG0306	phosphate transporter
E4U63_RS01610	COG2081	HI0933 family
E4U63_RS01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS01635	COG1129	ABC transporter
E4U63_RS01635	COG0842	Transport permease protein
E4U63_RS01640	COG0842	Transport permease protein
E4U63_RS01655	COG0191	fructose-bisphosphate aldolase activity
E4U63_RS01670	COG3775	system Galactitol-specific IIC component
E4U63_RS01675	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U63_RS01685	COG2188	Transcriptional regulator
E4U63_RS01695	COG1124	(ABC) transporter
E4U63_RS01700	COG0444	Belongs to the ABC transporter superfamily
E4U63_RS01705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U63_RS01710	COG0601	transmembrane transport
E4U63_RS01715	COG0747	negative chemotaxis
E4U63_RS01720	COG2091	lysine biosynthetic process via aminoadipic acid
E4U63_RS01725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U63_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS01740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U63_RS01765	COG1216	Glycosyl transferase, family 2
E4U63_RS01785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4U63_RS01795	COG0204	Acyl-transferase
E4U63_RS01815	COG0628	permease
E4U63_RS01830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4U63_RS01845	COG3714	YhhN family
E4U63_RS01855	COG3776	membrane
E4U63_RS01860	COG0742	ribosomal rna small subunit methyltransferase
E4U63_RS01865	COG0552	protein localization to endoplasmic reticulum
E4U63_RS01870	COG2884	Cell division ATP-binding protein ftsE
E4U63_RS01875	COG2177	Part of the ABC transporter FtsEX involved in
E4U63_RS01880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U63_RS01885	COG0683	leucine binding
E4U63_RS01900	COG0456	acetyltransferase
E4U63_RS01905	COG0683	leucine binding
E4U63_RS01910	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS01915	COG4177	L-phenylalanine transmembrane transporter activity
E4U63_RS01920	COG0411	ABC transporter
E4U63_RS01925	COG0410	ABC transporter
E4U63_RS01935	COG1653	transport
E4U63_RS01940	COG1175	transmembrane transport
E4U63_RS01950	COG3842	ATPase activity
E4U63_RS01955	COG0584	glycerophosphoryl diester phosphodiesterase
E4U63_RS01965	COG0405	Gamma-glutamyltransferase
E4U63_RS01975	COG1247	-acetyltransferase
E4U63_RS01980	COG0673	inositol 2-dehydrogenase activity
E4U63_RS01985	COG1741	Belongs to the pirin family
E4U63_RS01990	COG1609	Transcriptional regulator
E4U63_RS01995	COG3265	gluconokinase activity
E4U63_RS02000	COG2610	gluconate transmembrane transporter activity
E4U63_RS02005	COG0514	ATP-dependent DNA helicase (RecQ)
E4U63_RS02025	COG2095	MarC family integral membrane protein
E4U63_RS02030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4U63_RS02035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4U63_RS02055	COG0058	SHG alpha-glucan phosphorylase activity
E4U63_RS02060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4U63_RS02075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4U63_RS02090	COG1349	DNA-binding transcription factor activity
E4U63_RS02095	COG4650	regulator
E4U63_RS02100	COG1690	Belongs to the RtcB family
E4U63_RS02125	COG0058	SHG alpha-glucan phosphorylase activity
E4U63_RS02130	COG1640	4-alpha-glucanotransferase
E4U63_RS02135	COG2610	gluconate transmembrane transporter activity
E4U63_RS02145	COG1040	competence protein
E4U63_RS02155	COG5464	transposase or invertase
E4U63_RS02165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4U63_RS02170	COG1918	ferrous iron import across plasma membrane
E4U63_RS02175	COG2183	response to ionizing radiation
E4U63_RS02180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U63_RS02185	COG0745	RESPONSE REGULATOR receiver
E4U63_RS02190	COG2205	protein histidine kinase activity
E4U63_RS02200	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4U63_RS02210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4U63_RS02215	COG1011	Hydrolase
E4U63_RS02225	COG0494	nUDIX hydrolase
E4U63_RS02230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4U63_RS02235	COG4972	Pilus assembly protein
E4U63_RS02240	COG3166	PFAM Fimbrial assembly family protein
E4U63_RS02255	COG4796	Type ii and iii secretion system protein
E4U63_RS02270	COG3266	domain, Protein
E4U63_RS02275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4U63_RS02280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4U63_RS02285	COG0546	phosphoglycolate phosphatase activity
E4U63_RS02290	COG0180	Tryptophanyl-tRNA synthetase
E4U63_RS02295	COG2188	Transcriptional regulator
E4U63_RS02305	COG1082	Xylose isomerase domain protein TIM barrel
E4U63_RS02310	COG2222	sugar isomerase
E4U63_RS02315	COG0531	amino acid
E4U63_RS02330	COG2116	formate transmembrane transporter activity
E4U63_RS02335	COG2146	nitrite reductase [NAD(P)H] activity
E4U63_RS02340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4U63_RS02350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4U63_RS02360	COG2184	nucleotidyltransferase activity
E4U63_RS02365	COG0512	Glutamine amidotransferase of anthranilate synthase
E4U63_RS02370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4U63_RS02375	COG1289	transmembrane transporter activity
E4U63_RS02380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U63_RS02385	COG1765	OsmC-like protein
E4U63_RS02390	COG3954	Phosphoribulokinase
E4U63_RS02400	COG0429	hydrolase of the alpha beta-hydrolase fold
E4U63_RS02405	COG0488	(ABC) transporter
E4U63_RS02420	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4U63_RS02425	COG1047	Peptidyl-prolyl cis-trans
E4U63_RS02435	COG0545	Peptidyl-prolyl cis-trans isomerase
E4U63_RS02440	COG2964	Protein conserved in bacteria
E4U63_RS02510	COG0089	rRNA binding
E4U63_RS02600	COG0201	protein transport
E4U63_RS02640	COG0789	Transcriptional regulator
E4U63_RS02645	COG3036	rescue of stalled ribosome
E4U63_RS02655	COG0569	domain protein
E4U63_RS02675	COG0758	DNA mediated transformation
E4U63_RS02685	COG0551	DNA topoisomerase type I activity
E4U63_RS02690	COG0009	L-threonylcarbamoyladenylate synthase
E4U63_RS02705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4U63_RS02745	COG1126	abc transporter atp-binding protein
E4U63_RS02750	COG0765	amino acid transport
E4U63_RS02755	COG4597	amino acid ABC transporter
E4U63_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS02775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS02780	COG1309	transcriptional regulator
E4U63_RS02790	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4U63_RS02800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U63_RS02810	COG4145	pantothenate transmembrane transporter activity
E4U63_RS02815	COG3924	membrane
E4U63_RS02820	COG0439	Biotin carboxylase
E4U63_RS02825	COG0511	ligase activity, forming carbon-carbon bonds
E4U63_RS02830	COG0604	alcohol dehydrogenase
E4U63_RS02835	COG2200	EAL domain
E4U63_RS02835	COG2199	diguanylate cyclase activity
E4U63_RS02840	COG1077	Cell shape determining protein MreB Mrl
E4U63_RS02845	COG1792	Involved in formation and maintenance of cell shape
E4U63_RS02850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4U63_RS02855	COG0424	maF-like protein
E4U63_RS02860	COG1530	ribonuclease E activity
E4U63_RS02865	COG3164	Protein of unknown function
E4U63_RS02870	COG0312	modulator of DNA gyrase
E4U63_RS02875	COG0583	DNA-binding transcription factor activity
E4U63_RS02895	COG2732	(Barnase) inhibitor
E4U63_RS02915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U63_RS02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U63_RS02925	COG3105	Protein conserved in bacteria
E4U63_RS02930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4U63_RS02945	COG0625	glutathione transferase activity
E4U63_RS02950	COG2969	positive regulation of protein catabolic process
E4U63_RS02955	COG3069	C4-dicarboxylate transmembrane transporter activity
E4U63_RS02985	COG2731	YhcH YjgK YiaL family protein
E4U63_RS02990	COG4804	nuclease activity
E4U63_RS02995	COG0493	'glutamate synthase
E4U63_RS03000	COG0067	glutamate synthase
E4U63_RS03000	COG0069	glutamate synthase activity
E4U63_RS03000	COG0070	glutamate synthase
E4U63_RS03005	COG1242	4 iron, 4 sulfur cluster binding
E4U63_RS03010	COG5002	protein histidine kinase activity
E4U63_RS03010	COG2198	Histidine kinase
E4U63_RS03010	COG0784	Response regulator, receiver
E4U63_RS03015	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4U63_RS03025	COG0515	serine threonine protein kinase
E4U63_RS03030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS03045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4U63_RS03050	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4U63_RS03055	COG1137	ATPase activity
E4U63_RS03060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4U63_RS03065	COG3117	lipopolysaccharide transmembrane transporter activity
E4U63_RS03070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4U63_RS03075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4U63_RS03075	COG0517	IMP dehydrogenase activity
E4U63_RS03080	COG0530	calcium, potassium:sodium antiporter activity
E4U63_RS03085	COG1127	ABC transporter
E4U63_RS03090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4U63_RS03095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4U63_RS03100	COG2854	intermembrane phospholipid transfer
E4U63_RS03105	COG3113	response to antibiotic
E4U63_RS03110	COG5007	Belongs to the BolA IbaG family
E4U63_RS03120	COG3423	Transcriptional regulator
E4U63_RS03125	COG0142	geranyltranstransferase activity
E4U63_RS03140	COG0697	spore germination
E4U63_RS03150	COG2027	D-alanyl-D-alanine carboxypeptidase
E4U63_RS03155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U63_RS03160	COG1534	Rna-binding protein
E4U63_RS03170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4U63_RS03175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4U63_RS03185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4U63_RS03195	COG2194	sulfuric ester hydrolase activity
E4U63_RS03215	COG0195	Participates in both transcription termination and antitermination
E4U63_RS03255	COG0513	Belongs to the DEAD box helicase family
E4U63_RS03260	COG0814	amino acid
E4U63_RS03265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4U63_RS03270	COG0826	peptidase U32
E4U63_RS03275	COG0826	peptidase U32
E4U63_RS03280	COG3154	lipid carrier protein
E4U63_RS03285	COG3153	acetyltransferase
E4U63_RS03295	COG3787	Belongs to the UPF0306 family
E4U63_RS03300	COG0693	protein deglycase activity
E4U63_RS03305	COG0702	epimerase
E4U63_RS03310	COG0701	Predicted permease
E4U63_RS03315	COG2823	Periplasmic or secreted lipoprotein
E4U63_RS03335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4U63_RS03355	COG3188	usher protein
E4U63_RS03360	COG3121	Chaperone
E4U63_RS03365	COG3539	Fimbrial protein
E4U63_RS03375	COG3716	PTS system mannose fructose sorbose family IID component
E4U63_RS03385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS03395	COG2222	sugar isomerase
E4U63_RS03400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U63_RS03405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS03410	COG3716	PTS system mannose fructose sorbose family IID component
E4U63_RS03420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS03430	COG1349	DNA-binding transcription factor activity
E4U63_RS03440	COG2002	toxin-antitoxin pair type II binding
E4U63_RS03445	COG2721	sulfolactate sulfo-lyase activity
E4U63_RS03450	COG2271	Major facilitator Superfamily
E4U63_RS03460	COG2084	Dehydrogenase
E4U63_RS03465	COG1929	Belongs to the glycerate kinase type-1 family
E4U63_RS03490	COG0583	DNA-binding transcription factor activity
E4U63_RS03495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U63_RS03505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4U63_RS03510	COG1882	Formate acetyltransferase
E4U63_RS03515	COG0251	oxidation-reduction process
E4U63_RS03520	COG1760	l-serine dehydratase
E4U63_RS03525	COG0814	amino acid
E4U63_RS03540	COG1741	Belongs to the pirin family
E4U63_RS03545	COG0583	DNA-binding transcription factor activity
E4U63_RS03550	COG3152	Membrane
E4U63_RS03555	COG3152	Membrane
E4U63_RS03560	COG0435	Glutathione S-transferase
E4U63_RS03565	COG2259	Doxx family
E4U63_RS03575	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E4U63_RS03580	COG4575	ribosome binding
E4U63_RS03585	COG1422	Protein of unknown function (DUF1090)
E4U63_RS03595	COG0586	Pfam SNARE associated Golgi protein
E4U63_RS03600	COG2186	Transcriptional regulator
E4U63_RS03605	COG2271	Major facilitator Superfamily
E4U63_RS03615	COG2721	sulfolactate sulfo-lyase activity
E4U63_RS03625	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4U63_RS03630	COG0861	Integral membrane protein TerC family
E4U63_RS03635	COG0673	inositol 2-dehydrogenase activity
E4U63_RS03640	COG2949	membrane
E4U63_RS03645	COG1451	nucleotide metabolic process
E4U63_RS03655	COG4680	protein conserved in bacteria
E4U63_RS03660	COG5499	transcription regulator containing HTH domain
E4U63_RS03665	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4U63_RS03665	COG1902	pentaerythritol trinitrate reductase activity
E4U63_RS03670	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4U63_RS03670	COG3408	Glycogen debranching enzyme
E4U63_RS03680	COG0531	amino acid
E4U63_RS03685	COG2731	YhcH YjgK YiaL family protein
E4U63_RS03690	COG3250	beta-galactosidase activity
E4U63_RS03695	COG1609	Transcriptional regulator
E4U63_RS03700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4U63_RS03710	COG0840	transmembrane signaling receptor activity
E4U63_RS03715	COG1695	Transcriptional regulator
E4U63_RS03720	COG2375	cellular response to nickel ion
E4U63_RS03735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U63_RS03740	COG0358	DNA primase activity
E4U63_RS03745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4U63_RS03755	COG0471	metal ion transport
E4U63_RS03760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS03765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS03770	COG0583	DNA-binding transcription factor activity
E4U63_RS03780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4U63_RS03795	COG4991	sh3 domain protein
E4U63_RS03800	COG3025	triphosphatase activity
E4U63_RS03825	COG2268	Band 7 protein
E4U63_RS03830	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4U63_RS03860	COG3384	dioxygenase
E4U63_RS03865	COG0754	glutathionylspermidine amidase activity
E4U63_RS03875	COG1538	Outer membrane efflux protein
E4U63_RS03880	COG0494	nUDIX hydrolase
E4U63_RS03885	COG3151	Protein conserved in bacteria
E4U63_RS03890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4U63_RS03895	COG3150	esterase
E4U63_RS03900	COG0187	DNA topoisomerase II activity
E4U63_RS03905	COG4774	siderophore transport
E4U63_RS03910	COG1120	ATPase activity
E4U63_RS03915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U63_RS03920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U63_RS03930	COG1737	Transcriptional regulator
E4U63_RS03935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4U63_RS03940	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4U63_RS03945	COG0642	Histidine kinase
E4U63_RS03950	COG0745	RESPONSE REGULATOR receiver
E4U63_RS03955	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U63_RS03960	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E4U63_RS03965	COG4166	transmembrane transport
E4U63_RS03970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4U63_RS03975	COG0204	Acyl-transferase
E4U63_RS03980	COG2132	Multicopper oxidase
E4U63_RS03985	COG1032	radical SAM domain protein
E4U63_RS03990	COG4238	major outer membrane lipoprotein
E4U63_RS04000	COG0656	L-ascorbic acid biosynthetic process
E4U63_RS04005	COG1979	alcohol dehydrogenase
E4U63_RS04010	COG2207	Transcriptional regulator
E4U63_RS04015	COG0586	Pfam SNARE associated Golgi protein
E4U63_RS04020	COG0626	cystathionine gamma-synthase activity
E4U63_RS04025	COG0811	peptide transport
E4U63_RS04030	COG0848	biopolymer transport protein
E4U63_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS04045	COG0667	Aldo Keto reductase
E4U63_RS04060	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4U63_RS04065	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS04070	COG5557	Pfam Polysulphide reductase, NrfD
E4U63_RS04075	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4U63_RS04080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U63_RS04085	COG1773	rubredoxin
E4U63_RS04090	COG0375	protein maturation
E4U63_RS04095	COG0298	carbon dioxide binding
E4U63_RS04100	COG0625	glutathione transferase activity
E4U63_RS04105	COG0754	glutathionylspermidine amidase activity
E4U63_RS04130	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS04135	COG4372	Transposase
E4U63_RS04140	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS04205	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS04220	COG0582	viral genome integration into host DNA
E4U63_RS04230	COG1811	Na channel or pump
E4U63_RS04235	COG1982	Orn Lys Arg decarboxylase major
E4U63_RS04240	COG2211	Major facilitator Superfamily
E4U63_RS04255	COG1194	a g-specific adenine glycosylase
E4U63_RS04265	COG3171	Protein conserved in bacteria
E4U63_RS04275	COG0252	asparaginase activity
E4U63_RS04285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4U63_RS04290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4U63_RS04300	COG0762	integral membrane protein
E4U63_RS04305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4U63_RS04310	COG2805	Type II/IV secretion system protein
E4U63_RS04325	COG0189	ligase activity
E4U63_RS04330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4U63_RS04335	COG2356	endonuclease I
E4U63_RS04340	COG3091	SprT-like family
E4U63_RS04345	COG2814	Major facilitator Superfamily
E4U63_RS04365	COG1166	arginine decarboxylase activity
E4U63_RS04380	COG0501	Belongs to the peptidase M48B family
E4U63_RS04385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4U63_RS04390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS04395	COG2213	PTS system mannitol-specific
E4U63_RS04400	COG1063	alcohol dehydrogenase
E4U63_RS04405	COG1494	fructose-1,6-bisphosphatase
E4U63_RS04415	COG1072	(Pantothenic acid kinase))
E4U63_RS04420	COG1122	ATPase activity
E4U63_RS04425	COG1122	ATPase activity
E4U63_RS04450	COG0126	phosphoglycerate kinase activity
E4U63_RS04455	COG0191	fructose-bisphosphate aldolase activity
E4U63_RS04460	COG0668	transmembrane transport
E4U63_RS04470	COG2968	Membrane
E4U63_RS04480	COG0427	acetyl-CoA hydrolase
E4U63_RS04485	COG1024	Enoyl-CoA hydratase
E4U63_RS04490	COG1703	isobutyryl-CoA mutase activity
E4U63_RS04495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U63_RS04495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U63_RS04510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4U63_RS04525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4U63_RS04545	COG0006	proline dipeptidase activity
E4U63_RS04550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U63_RS04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U63_RS04580	COG2723	6-phospho-beta-galactosidase activity
E4U63_RS04590	COG1272	protein, Hemolysin III
E4U63_RS04600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4U63_RS04610	COG0716	FMN binding
E4U63_RS04615	COG4974	Belongs to the 'phage' integrase family
E4U63_RS04620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U63_RS04625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4U63_RS04635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4U63_RS04655	COG2233	PERMEase
E4U63_RS04670	COG2252	PERMEase
E4U63_RS04675	COG0402	S-adenosylhomocysteine deaminase activity
E4U63_RS04680	COG2233	PERMEase
E4U63_RS04685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U63_RS04685	COG2080	2 iron, 2 sulfur cluster binding
E4U63_RS04690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U63_RS04700	COG0493	'glutamate synthase
E4U63_RS04700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS04705	COG2068	MobA-Related Protein
E4U63_RS04710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4U63_RS04715	COG3608	succinylglutamate desuccinylase aspartoacylase
E4U63_RS04715	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4U63_RS04720	COG0549	Belongs to the carbamate kinase family
E4U63_RS04730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4U63_RS04735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U63_RS04740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4U63_RS04750	COG2080	2 iron, 2 sulfur cluster binding
E4U63_RS04755	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U63_RS04760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U63_RS04765	COG4942	peptidase
E4U63_RS04785	COG2207	Transcriptional regulator
E4U63_RS04890	COG2197	response regulator
E4U63_RS04895	COG0741	lytic transglycosylase activity
E4U63_RS04905	COG0457	Tetratricopeptide repeat
E4U63_RS04905	COG3710	Transcriptional regulator
E4U63_RS04910	COG0457	Tetratricopeptide repeat
E4U63_RS04935	COG3710	Transcriptional regulator
E4U63_RS04940	COG2771	luxR family
E4U63_RS04945	COG0814	amino acid
E4U63_RS04950	COG0183	Belongs to the thiolase family
E4U63_RS04960	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS04965	COG2814	Major facilitator Superfamily
E4U63_RS04970	COG1794	racemase activity, acting on amino acids and derivatives
E4U63_RS04975	COG0583	DNA-binding transcription factor activity
E4U63_RS04985	COG1609	Transcriptional regulator
E4U63_RS05000	COG0667	Aldo Keto reductase
E4U63_RS05010	COG0861	Integral membrane protein TerC family
E4U63_RS05025	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E4U63_RS05040	COG2165	general secretion pathway protein
E4U63_RS05045	COG4795	General secretion pathway protein
E4U63_RS05055	COG4967	type IV pilus modification protein PilV
E4U63_RS05060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4U63_RS05065	COG1025	Belongs to the peptidase M16 family
E4U63_RS05070	COG1074	ATP-dependent DNA helicase activity
E4U63_RS05075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4U63_RS05080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4U63_RS05080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4U63_RS05085	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U63_RS05105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4U63_RS05110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4U63_RS05115	COG2166	iron-sulfur cluster assembly
E4U63_RS05120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4U63_RS05130	COG0583	DNA-binding transcription factor activity
E4U63_RS05135	COG2363	Small membrane protein
E4U63_RS05145	COG1349	DNA-binding transcription factor activity
E4U63_RS05155	COG1070	Carbohydrate kinase
E4U63_RS05165	COG0738	Major facilitator superfamily
E4U63_RS05170	COG0235	Class ii aldolase
E4U63_RS05175	COG1454	alcohol dehydrogenase
E4U63_RS05185	COG1760	l-serine dehydratase
E4U63_RS05190	COG0814	amino acid
E4U63_RS05195	COG1611	Belongs to the LOG family
E4U63_RS05210	COG3098	single-species biofilm formation
E4U63_RS05215	COG0564	pseudouridine synthase activity
E4U63_RS05220	COG0716	FMN binding
E4U63_RS05225	COG2271	Major facilitator Superfamily
E4U63_RS05235	COG4948	Mandelate Racemase Muconate Lactonizing
E4U63_RS05240	COG3850	Histidine kinase
E4U63_RS05240	COG3437	response regulator, receiver
E4U63_RS05240	COG4999	Histidine kinase
E4U63_RS05240	COG2205	protein histidine kinase activity
E4U63_RS05245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4U63_RS05250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4U63_RS05255	COG2336	PFAM SpoVT AbrB
E4U63_RS05260	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4U63_RS05265	COG3956	TIGRFAM MazG family protein
E4U63_RS05280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4U63_RS05290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4U63_RS05300	COG0602	queuosine metabolic process
E4U63_RS05305	COG1070	Carbohydrate kinase
E4U63_RS05310	COG2223	nitrite transmembrane transporter activity
E4U63_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS05320	COG0277	FAD linked oxidase domain protein
E4U63_RS05330	COG2086	electron transfer activity
E4U63_RS05340	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E4U63_RS05345	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U63_RS05355	COG0720	synthase
E4U63_RS05360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4U63_RS05385	COG1857	crispr-associated protein
E4U63_RS05400	COG1518	maintenance of DNA repeat elements
E4U63_RS05405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS05410	COG2234	aminopeptidase activity
E4U63_RS05465	COG4942	peptidase
E4U63_RS05465	COG1388	LysM domain
E4U63_RS05470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4U63_RS05475	COG1846	Transcriptional regulator
E4U63_RS05480	COG0163	prenyltransferase activity
E4U63_RS05485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4U63_RS05495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4U63_RS05515	COG3604	Transcriptional regulator
E4U63_RS05520	COG0309	Hydrogenase expression formation protein (HypE)
E4U63_RS05525	COG0409	Hydrogenase expression formation protein
E4U63_RS05530	COG0298	carbon dioxide binding
E4U63_RS05535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4U63_RS05540	COG0375	protein maturation
E4U63_RS05550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS05555	COG0651	ATP synthesis coupled electron transport
E4U63_RS05560	COG0650	Formate hydrogenlyase subunit 4
E4U63_RS05565	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4U63_RS05565	COG3261	NADH dehydrogenase
E4U63_RS05570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U63_RS05575	COG3260	NADH ubiquinone oxidoreductase 20
E4U63_RS05585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U63_RS05590	COG2723	6-phospho-beta-galactosidase activity
E4U63_RS05595	COG1263	PTS System
E4U63_RS05595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS05600	COG1609	Transcriptional regulator
E4U63_RS05605	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS05610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4U63_RS05630	COG0517	IMP dehydrogenase activity
E4U63_RS05630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4U63_RS05635	COG1349	DNA-binding transcription factor activity
E4U63_RS05640	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS05660	COG3730	PTS system glucitol sorbitol-specific
E4U63_RS05665	COG2951	lytic endotransglycosylase activity
E4U63_RS05670	COG1546	Belongs to the CinA family
E4U63_RS05685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4U63_RS05690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4U63_RS05720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U63_RS05725	COG1238	metal cluster binding
E4U63_RS05740	COG2814	Major facilitator Superfamily
E4U63_RS05745	COG1566	PFAM secretion protein HlyD family protein
E4U63_RS05750	COG1846	Transcriptional regulator
E4U63_RS05760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4U63_RS05765	COG2814	Major facilitator Superfamily
E4U63_RS05770	COG2113	Glycine betaine
E4U63_RS05775	COG4176	ABC-type proline glycine betaine transport system permease component
E4U63_RS05780	COG4175	Glycine betaine
E4U63_RS05785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U63_RS05790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U63_RS05800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U63_RS05805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U63_RS05815	COG4575	ribosome binding
E4U63_RS05830	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4U63_RS05835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U63_RS05840	COG0640	Transcriptional regulator
E4U63_RS05845	COG0401	homolog of Blt101
E4U63_RS05850	COG1652	LysM domain
E4U63_RS05855	COG1802	Transcriptional regulator
E4U63_RS05860	COG1113	amino acid transport
E4U63_RS05865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4U63_RS05870	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS05875	COG0579	oxidoreductase
E4U63_RS05910	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS06015	COG2867	negative regulation of translational initiation
E4U63_RS06025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U63_RS06030	COG0497	DNA recombination
E4U63_RS06045	COG4536	flavin adenine dinucleotide binding
E4U63_RS06050	COG4137	Cytochrome C assembly protein
E4U63_RS06055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4U63_RS06080	COG2885	chlorophyll binding
E4U63_RS06085	COG2199	diguanylate cyclase activity
E4U63_RS06100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U63_RS06105	COG1605	Chorismate mutase
E4U63_RS06105	COG0287	Prephenate dehydrogenase
E4U63_RS06110	COG1605	Chorismate mutase
E4U63_RS06110	COG0077	Prephenate dehydratase
E4U63_RS06120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4U63_RS06125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U63_RS06130	COG0564	pseudouridine synthase activity
E4U63_RS06140	COG0542	response to heat
E4U63_RS06165	COG0477	Major facilitator Superfamily
E4U63_RS06170	COG5544	Lipoprotein
E4U63_RS06175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U63_RS06180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U63_RS06180	COG1042	CoA-binding domain protein
E4U63_RS06180	COG0045	succinate-CoA ligase (ADP-forming) activity
E4U63_RS06190	COG3118	belongs to the thioredoxin family
E4U63_RS06195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U63_RS06210	COG1280	lysine exporter protein (LysE YggA)
E4U63_RS06215	COG0583	DNA-binding transcription factor activity
E4U63_RS06220	COG0513	Belongs to the DEAD box helicase family
E4U63_RS06225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4U63_RS06230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4U63_RS06240	COG1595	DNA-templated transcription, initiation
E4U63_RS06245	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E4U63_RS06250	COG3026	antisigma factor binding
E4U63_RS06255	COG3086	response to oxidative stress
E4U63_RS06265	COG0681	Belongs to the peptidase S26 family
E4U63_RS06285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4U63_RS06300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS06305	COG1737	Transcriptional regulator
E4U63_RS06310	COG0560	Phosphoserine phosphatase
E4U63_RS06315	COG0590	tRNA wobble adenosine to inosine editing
E4U63_RS06320	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4U63_RS06325	COG0047	phosphoribosylformylglycinamidine synthase activity
E4U63_RS06325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4U63_RS06330	COG2205	protein histidine kinase activity
E4U63_RS06335	COG3170	Tfp pilus assembly protein FimV
E4U63_RS06340	COG2204	response regulator
E4U63_RS06345	COG0347	Belongs to the P(II) protein family
E4U63_RS06350	COG1017	nitric oxide dioxygenase activity
E4U63_RS06350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U63_RS06360	COG1940	carbohydrate kinase activity
E4U63_RS06365	COG0457	Tetratricopeptide repeat
E4U63_RS06370	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS06375	COG1129	ABC transporter
E4U63_RS06380	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS06385	COG1063	alcohol dehydrogenase
E4U63_RS06390	COG1063	alcohol dehydrogenase
E4U63_RS06395	COG2017	converts alpha-aldose to the beta-anomer
E4U63_RS06400	COG2259	Doxx family
E4U63_RS06425	COG4638	Rieske (2fe-2S)
E4U63_RS06430	COG0583	DNA-binding transcription factor activity
E4U63_RS06435	COG2814	Major facilitator Superfamily
E4U63_RS06440	COG3711	transcriptional antiterminator
E4U63_RS06445	COG1073	alpha beta
E4U63_RS06450	COG0483	inositol monophosphate 1-phosphatase activity
E4U63_RS06470	COG0822	iron-sulfur transferase activity
E4U63_RS06490	COG0633	Ferredoxin
E4U63_RS06495	COG2975	iron-sulfur cluster assembly
E4U63_RS06510	COG2897	thiosulfate sulfurtransferase activity
E4U63_RS06515	COG2373	Large extracellular alpha-helical protein
E4U63_RS06520	COG4953	penicillin-binding protein 1C
E4U63_RS06525	COG0243	molybdopterin cofactor binding
E4U63_RS06530	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS06535	COG3302	dmso reductase anchor subunit
E4U63_RS06570	COG2976	Protein conserved in bacteria
E4U63_RS06585	COG1645	bacterial-type flagellum-dependent swarming motility
E4U63_RS06595	COG0517	IMP dehydrogenase activity
E4U63_RS06595	COG0516	GMP reductase activity
E4U63_RS06610	COG3133	Outer membrane lipoprotein
E4U63_RS06625	COG2200	EAL domain
E4U63_RS06630	COG0248	Ppx GppA phosphatase
E4U63_RS06635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4U63_RS06640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4U63_RS06655	COG2233	PERMEase
E4U63_RS06665	COG1393	Belongs to the ArsC family
E4U63_RS06670	COG4783	chaperone-mediated protein folding
E4U63_RS06675	COG0628	permease
E4U63_RS06680	COG2116	formate transmembrane transporter activity
E4U63_RS06685	COG3604	Transcriptional regulator
E4U63_RS06695	COG3260	NADH ubiquinone oxidoreductase 20
E4U63_RS06700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U63_RS06705	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E4U63_RS06705	COG3261	NADH dehydrogenase
E4U63_RS06710	COG0651	ATP synthesis coupled electron transport
E4U63_RS06715	COG4237	Hydrogenase 4 membrane
E4U63_RS06720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4U63_RS06725	COG0650	Formate hydrogenlyase subunit 4
E4U63_RS06730	COG0651	ATP synthesis coupled electron transport
E4U63_RS06735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS06740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4U63_RS06745	COG2716	regulation of RNA biosynthetic process
E4U63_RS06755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4U63_RS06765	COG2321	neutral zinc metallopeptidase
E4U63_RS06775	COG0400	carboxylic ester hydrolase activity
E4U63_RS06790	COG1393	Belongs to the ArsC family
E4U63_RS06800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U63_RS06805	COG3850	Histidine kinase
E4U63_RS06810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS06810	COG0493	'glutamate synthase
E4U63_RS06820	COG5342	invasion associated locus B
E4U63_RS06825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4U63_RS06830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U63_RS06835	COG0280	phosphate acetyltransferase
E4U63_RS06835	COG0281	malic enzyme
E4U63_RS06840	COG4810	utilization protein
E4U63_RS06845	COG4917	ethanolamine utilization protein
E4U63_RS06850	COG4766	ethanolamine catabolic process
E4U63_RS06855	COG4812	Cobalamin adenosyltransferase
E4U63_RS06860	COG0280	phosphate acetyltransferase
E4U63_RS06865	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4U63_RS06870	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E4U63_RS06875	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS06880	COG4820	ethanolamine utilization protein (EutJ)
E4U63_RS06885	COG1454	alcohol dehydrogenase
E4U63_RS06890	COG3192	ethanolamine utilization protein
E4U63_RS06895	COG4819	ethanolamine utilization protein
E4U63_RS06900	COG4303	Ethanolamine ammonia lyase large subunit
E4U63_RS06910	COG4816	utilization protein
E4U63_RS06915	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E4U63_RS06920	COG2207	Transcriptional regulator
E4U63_RS06930	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U63_RS06950	COG2837	iron assimilation
E4U63_RS06955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U63_RS06960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS06960	COG1263	PTS System
E4U63_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS06980	COG4150	thiosulfate binding
E4U63_RS06985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4U63_RS06990	COG4208	sulfate ABC transporter
E4U63_RS06995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4U63_RS07000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4U63_RS07015	COG2190	(PTS) system
E4U63_RS07020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U63_RS07025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS07030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4U63_RS07050	COG3530	Putative quorum-sensing-regulated virulence factor
E4U63_RS07055	COG0385	Bile acid
E4U63_RS07060	COG0583	DNA-binding transcription factor activity
E4U63_RS07100	COG0675	Transposase, IS605 OrfB family
E4U63_RS07105	COG3415	Transposase
E4U63_RS07110	COG3415	Transposase
E4U63_RS07125	COG2200	EAL domain
E4U63_RS07125	COG2199	diguanylate cyclase activity
E4U63_RS07130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U63_RS07155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS07160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS07165	COG0006	proline dipeptidase activity
E4U63_RS07170	COG1363	Peptidase, m42
E4U63_RS07175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS07175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U63_RS07175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS07180	COG2207	Transcriptional regulator
E4U63_RS07185	COG3279	Response regulator of the LytR AlgR family
E4U63_RS07190	COG3275	phosphorelay sensor kinase activity
E4U63_RS07195	COG0436	Aminotransferase
E4U63_RS07205	COG1560	Kdo2-lipid A biosynthetic process
E4U63_RS07230	COG0028	Belongs to the TPP enzyme family
E4U63_RS07235	COG0679	Auxin Efflux Carrier
E4U63_RS07240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4U63_RS07245	COG2198	Histidine kinase
E4U63_RS07245	COG2205	protein histidine kinase activity
E4U63_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS07245	COG0784	Response regulator, receiver
E4U63_RS07250	COG2197	response regulator
E4U63_RS07255	COG1566	PFAM secretion protein HlyD family protein
E4U63_RS07260	COG0477	Major facilitator Superfamily
E4U63_RS07350	COG0582	viral genome integration into host DNA
E4U63_RS07360	COG2116	formate transmembrane transporter activity
E4U63_RS07365	COG2853	Lipoprotein
E4U63_RS07375	COG2067	long-chain fatty acid transport protein
E4U63_RS07380	COG3691	Protein conserved in bacteria
E4U63_RS07395	COG2062	phosphohistidine phosphatase, SixA
E4U63_RS07400	COG3539	Fimbrial protein
E4U63_RS07405	COG3188	usher protein
E4U63_RS07410	COG3121	Chaperone
E4U63_RS07415	COG3539	Fimbrial protein
E4U63_RS07420	COG3539	Fimbrial protein
E4U63_RS07425	COG3539	Fimbrial protein
E4U63_RS07455	COG0730	response to heat
E4U63_RS07460	COG3101	peptidyl-lysine hydroxylation
E4U63_RS07470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4U63_RS07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4U63_RS07475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U63_RS07480	COG2814	Major facilitator Superfamily
E4U63_RS07495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4U63_RS07505	COG0586	Pfam SNARE associated Golgi protein
E4U63_RS07515	COG0285	dihydrofolate synthase activity
E4U63_RS07520	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4U63_RS07525	COG1286	toxin biosynthetic process
E4U63_RS07530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4U63_RS07535	COG0163	prenyltransferase activity
E4U63_RS07540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS07545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS07550	COG4215	(ABC) transporter
E4U63_RS07555	COG4160	amino acid transport
E4U63_RS07560	COG4598	ABC transporter
E4U63_RS07565	COG5464	transposase or invertase
E4U63_RS07570	COG1090	epimerase
E4U63_RS07575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4U63_RS07580	COG0625	glutathione transferase activity
E4U63_RS07585	COG0625	glutathione transferase activity
E4U63_RS07590	COG0622	Phosphoesterase
E4U63_RS07595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4U63_RS07600	COG1288	antiporter activity
E4U63_RS07605	COG0857	belongs to the CobB CobQ family
E4U63_RS07605	COG0280	phosphate acetyltransferase
E4U63_RS07610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4U63_RS07625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U63_RS07630	COG0490	domain, Protein
E4U63_RS07630	COG0471	metal ion transport
E4U63_RS07640	COG0436	Aminotransferase
E4U63_RS07645	COG0583	DNA-binding transcription factor activity
E4U63_RS07665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4U63_RS07670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4U63_RS07675	COG1034	ATP synthesis coupled electron transport
E4U63_RS07690	COG0839	Belongs to the complex I subunit 6 family
E4U63_RS07700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4U63_RS07705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U63_RS07730	COG5160	protein modification by small protein removal
E4U63_RS07735	COG1234	tRNA 3'-trailer cleavage
E4U63_RS07740	COG2153	protein acetylation
E4U63_RS07745	COG4575	ribosome binding
E4U63_RS07750	COG1169	isochorismate synthase
E4U63_RS07765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4U63_RS07775	COG0318	PFAM AMP-dependent synthetase and ligase
E4U63_RS07820	COG0406	alpha-ribazole phosphatase activity
E4U63_RS07840	COG1414	Transcriptional regulator
E4U63_RS07845	COG4948	Mandelate Racemase Muconate Lactonizing
E4U63_RS07850	COG2271	Major facilitator Superfamily
E4U63_RS07865	COG3836	Belongs to the HpcH HpaI aldolase family
E4U63_RS07870	COG5464	transposase or invertase
E4U63_RS07875	COG0247	lactate metabolic process
E4U63_RS07885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4U63_RS07890	COG2271	Major facilitator Superfamily
E4U63_RS07895	COG0584	glycerophosphoryl diester phosphodiesterase
E4U63_RS07905	COG0583	DNA-binding transcription factor activity
E4U63_RS07910	COG2814	Major facilitator Superfamily
E4U63_RS07915	COG3642	lipopolysaccharide core region biosynthetic process
E4U63_RS07920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U63_RS07925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U63_RS07930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4U63_RS07935	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS07945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4U63_RS07950	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E4U63_RS07955	COG3234	Protein of unknown function (DUF1175)
E4U63_RS07960	COG2373	Large extracellular alpha-helical protein
E4U63_RS07965	COG5445	Predicted secreted protein (DUF2300)
E4U63_RS07970	COG5445	Predicted secreted protein (DUF2300)
E4U63_RS07975	COG4676	Protein conserved in bacteria
E4U63_RS07980	COG0784	Response regulator, receiver
E4U63_RS07980	COG2205	protein histidine kinase activity
E4U63_RS07985	COG2197	response regulator
E4U63_RS07990	COG2198	Histidine kinase
E4U63_RS07990	COG0642	Histidine kinase
E4U63_RS07995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U63_RS08000	COG1477	protein flavinylation
E4U63_RS08005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4U63_RS08005	COG2169	Transcriptional regulator
E4U63_RS08010	COG3145	DNA-N1-methyladenine dioxygenase activity
E4U63_RS08015	COG4615	Cyclic peptide transporter
E4U63_RS08030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS08030	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4U63_RS08035	COG3062	negative regulation of establishment of protein localization
E4U63_RS08045	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS08050	COG0348	domain, Protein
E4U63_RS08055	COG3043	anaerobic respiration
E4U63_RS08060	COG3005	denitrification pathway
E4U63_RS08065	COG4133	protoheme IX ABC transporter activity
E4U63_RS08070	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U63_RS08075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U63_RS08080	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4U63_RS08090	COG1138	Cytochrome C-type biogenesis protein
E4U63_RS08095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4U63_RS08100	COG3088	subunit of a heme lyase
E4U63_RS08100	COG4235	cytochrome complex assembly
E4U63_RS08105	COG2197	response regulator
E4U63_RS08110	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS08120	COG3083	sulfuric ester hydrolase activity
E4U63_RS08140	COG1061	Type III restriction enzyme res subunit
E4U63_RS08145	COG1187	pseudouridine synthase activity
E4U63_RS08150	COG2814	Major facilitator Superfamily
E4U63_RS08160	COG4172	Belongs to the ABC transporter superfamily
E4U63_RS08165	COG4239	(ABC) transporter, permease
E4U63_RS08170	COG4174	ABC transporter (Permease)
E4U63_RS08175	COG4166	transmembrane transport
E4U63_RS08180	COG2200	EAL domain
E4U63_RS08185	COG0791	NLP P60 protein
E4U63_RS08190	COG0671	phosphoesterase, PA-phosphatase related
E4U63_RS08195	COG0523	cobalamin synthesis protein
E4U63_RS08200	COG0246	Mannitol dehydrogenase
E4U63_RS08215	COG2814	Major facilitator Superfamily
E4U63_RS08220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS08220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS08225	COG1105	Belongs to the carbohydrate kinase PfkB family
E4U63_RS08230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS08230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4U63_RS08230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS08235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS08240	COG2313	pseudouridylate synthase activity
E4U63_RS08245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U63_RS08250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U63_RS08260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4U63_RS08265	COG1522	sequence-specific DNA binding
E4U63_RS08265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS08275	COG2855	membrane
E4U63_RS08280	COG0583	DNA-binding transcription factor activity
E4U63_RS08285	COG0833	amino acid
E4U63_RS08290	COG4771	TonB-dependent receptor
E4U63_RS08295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4U63_RS08305	COG2311	Membrane
E4U63_RS08310	COG1609	Transcriptional regulator
E4U63_RS08315	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS08320	COG1129	ABC transporter
E4U63_RS08325	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS08330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4U63_RS08330	COG0167	dihydroorotate dehydrogenase activity
E4U63_RS08335	COG0493	'glutamate synthase
E4U63_RS08345	COG2949	membrane
E4U63_RS08355	COG1346	cytolysis
E4U63_RS08370	COG2271	Major facilitator Superfamily
E4U63_RS08385	COG0625	glutathione transferase activity
E4U63_RS08390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U63_RS08395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U63_RS08405	COG1538	Outer membrane efflux protein
E4U63_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS08415	COG0586	Pfam SNARE associated Golgi protein
E4U63_RS08425	COG1686	Belongs to the peptidase S11 family
E4U63_RS08430	COG0277	FAD linked oxidase domain protein
E4U63_RS08435	COG1472	Belongs to the glycosyl hydrolase 3 family
E4U63_RS08440	COG1732	Glycine betaine
E4U63_RS08445	COG1174	glycine betaine transport
E4U63_RS08450	COG1125	glycine betaine transport
E4U63_RS08455	COG1174	glycine betaine transport
E4U63_RS08465	COG0789	Transcriptional regulator
E4U63_RS08490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U63_RS08565	COG3772	lysozyme
E4U63_RS08610	COG0740	serine-type endopeptidase activity
E4U63_RS08685	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS08710	COG3275	phosphorelay sensor kinase activity
E4U63_RS08715	COG3279	Response regulator of the LytR AlgR family
E4U63_RS08720	COG4807	Protein conserved in bacteria
E4U63_RS08725	COG4808	Protein conserved in bacteria
E4U63_RS08730	COG4715	Zinc finger, swim domain protein
E4U63_RS08735	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E4U63_RS08740	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4U63_RS08745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4U63_RS08750	COG0714	Associated with various cellular activities
E4U63_RS08760	COG3831	ATPase activity
E4U63_RS08780	COG0489	protein tyrosine kinase activity
E4U63_RS08790	COG3539	Fimbrial protein
E4U63_RS08795	COG3121	Chaperone
E4U63_RS08800	COG3188	usher protein
E4U63_RS08820	COG5455	response to cobalt ion
E4U63_RS08825	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4U63_RS08855	COG0351	phosphomethylpyrimidine kinase
E4U63_RS08860	COG3757	hydrolase, family 25
E4U63_RS08865	COG2188	Transcriptional regulator
E4U63_RS08870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS08875	COG1397	ADP-ribosylglycohydrolase
E4U63_RS08880	COG2211	Major facilitator Superfamily
E4U63_RS08885	COG1830	Aldolase
E4U63_RS08900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS08905	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U63_RS08910	COG3775	system Galactitol-specific IIC component
E4U63_RS08915	COG1063	alcohol dehydrogenase
E4U63_RS08940	COG3422	double-strand break repair
E4U63_RS08945	COG0745	RESPONSE REGULATOR receiver
E4U63_RS08950	COG2205	protein histidine kinase activity
E4U63_RS08965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U63_RS08990	COG4245	von Willebrand factor, type A
E4U63_RS08995	COG0631	protein serine/threonine phosphatase activity
E4U63_RS09000	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E4U63_RS09005	COG0443	Heat shock 70 kDa protein
E4U63_RS09010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E4U63_RS09020	COG0572	uridine kinase
E4U63_RS09030	COG2982	Protein involved in outer membrane biogenesis
E4U63_RS09045	COG1253	flavin adenine dinucleotide binding
E4U63_RS09055	COG1596	polysaccharide export
E4U63_RS09060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4U63_RS09065	COG3206	protein involved in exopolysaccharide biosynthesis
E4U63_RS09065	COG0489	protein tyrosine kinase activity
E4U63_RS09070	COG0463	Glycosyl transferase, family 2
E4U63_RS09075	COG1045	serine acetyltransferase
E4U63_RS09080	COG0438	transferase activity, transferring glycosyl groups
E4U63_RS09090	COG1216	Glycosyl transferase, family 2
E4U63_RS09095	COG0110	maltose O-acetyltransferase activity
E4U63_RS09100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4U63_RS09105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U63_RS09110	COG1051	belongs to the nudix hydrolase family
E4U63_RS09115	COG0297	glycogen (starch) synthase activity
E4U63_RS09120	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4U63_RS09120	COG0662	Cupin 2, conserved barrel domain protein
E4U63_RS09125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4U63_RS09130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4U63_RS09135	COG2244	polysaccharide biosynthetic process
E4U63_RS09140	COG2327	Polysaccharide pyruvyl transferase
E4U63_RS09145	COG0438	transferase activity, transferring glycosyl groups
E4U63_RS09155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U63_RS09160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4U63_RS09185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4U63_RS09195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4U63_RS09200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U63_RS09205	COG1051	belongs to the nudix hydrolase family
E4U63_RS09210	COG0662	Cupin 2, conserved barrel domain protein
E4U63_RS09210	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4U63_RS09215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4U63_RS09225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4U63_RS09230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4U63_RS09255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4U63_RS09260	COG0131	Imidazoleglycerol-phosphate dehydratase
E4U63_RS09260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4U63_RS09270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4U63_RS09285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U63_RS09290	COG0583	DNA-binding transcription factor activity
E4U63_RS09300	COG0531	amino acid
E4U63_RS09305	COG2391	methyltransferase activity
E4U63_RS09310	COG0425	Belongs to the sulfur carrier protein TusA family
E4U63_RS09315	COG2925	Exonuclease
E4U63_RS09320	COG0582	viral genome integration into host DNA
E4U63_RS09575	COG3772	lysozyme
E4U63_RS09680	COG1185	polyribonucleotide nucleotidyltransferase activity
E4U63_RS09710	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS09715	COG4372	Transposase
E4U63_RS09730	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS09740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U63_RS09750	COG1686	Belongs to the peptidase S11 family
E4U63_RS09760	COG1289	transmembrane transporter activity
E4U63_RS09770	COG4917	ethanolamine utilization protein
E4U63_RS09805	COG2003	Belongs to the UPF0758 family
E4U63_RS09840	COG4771	TonB-dependent receptor
E4U63_RS09845	COG4372	Transposase
E4U63_RS09850	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS09860	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E4U63_RS09875	COG1376	ErfK ybiS ycfS ynhG family protein
E4U63_RS09885	COG0583	DNA-binding transcription factor activity
E4U63_RS09890	COG0583	DNA-binding transcription factor activity
E4U63_RS09900	COG0534	Mate efflux family protein
E4U63_RS09910	COG0217	transcriptional regulatory protein
E4U63_RS09915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4U63_RS09920	COG0477	Major facilitator Superfamily
E4U63_RS09970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS10015	COG1846	Transcriptional regulator
E4U63_RS10065	COG1403	HNH endonuclease
E4U63_RS10070	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS10125	COG3772	lysozyme
E4U63_RS10155	COG4220	transposase activity
E4U63_RS10240	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS10260	COG3038	cytochrome b561
E4U63_RS10265	COG3443	Belongs to the bacterial solute-binding protein 9 family
E4U63_RS10280	COG2351	hydroxyisourate hydrolase activity
E4U63_RS10285	COG0745	RESPONSE REGULATOR receiver
E4U63_RS10290	COG2205	protein histidine kinase activity
E4U63_RS10310	COG1418	mRNA catabolic process
E4U63_RS10315	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4U63_RS10320	COG3727	T/G mismatch-specific endonuclease activity
E4U63_RS10325	COG0697	spore germination
E4U63_RS10330	COG2354	Protein conserved in bacteria
E4U63_RS10335	COG5475	Uncharacterized small protein (DUF2158)
E4U63_RS10340	COG3706	GGDEF domain
E4U63_RS10360	COG2197	response regulator
E4U63_RS10365	COG1684	flagellar biosynthetic protein fliR
E4U63_RS10370	COG1987	bacterial-type flagellum assembly
E4U63_RS10375	COG1338	Plays a role in the flagellum-specific transport system
E4U63_RS10380	COG3190	flagellar
E4U63_RS10385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U63_RS10390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U63_RS10395	COG1580	Controls the rotational direction of flagella during chemotaxis
E4U63_RS10400	COG3144	bacterial-type flagellum assembly
E4U63_RS10405	COG2882	bacterial-type flagellum organization
E4U63_RS10410	COG1157	protein secretion by the type III secretion system
E4U63_RS10415	COG1317	bacterial-type flagellum organization
E4U63_RS10420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4U63_RS10425	COG1766	The M ring may be actively involved in energy transduction
E4U63_RS10440	COG0454	-acetyltransferase
E4U63_RS10450	COG0454	-acetyltransferase
E4U63_RS10455	COG2135	peptidase activity
E4U63_RS10460	COG0425	Belongs to the sulfur carrier protein TusA family
E4U63_RS10465	COG2391	methyltransferase activity
E4U63_RS10475	COG0366	Alpha amylase catalytic
E4U63_RS10485	COG1516	flagellar protein fliS
E4U63_RS10490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4U63_RS10500	COG1191	sigma factor activity
E4U63_RS10530	COG2197	response regulator
E4U63_RS10545	COG2197	response regulator
E4U63_RS10620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U63_RS10720	COG4974	Belongs to the 'phage' integrase family
E4U63_RS10725	COG3318	Belongs to the UPF0149 family
E4U63_RS10725	COG3012	SEC-C Motif Domain Protein
E4U63_RS10730	COG0814	amino acid
E4U63_RS10740	COG1528	Iron-storage protein
E4U63_RS10760	COG1528	Iron-storage protein
E4U63_RS10765	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS10770	COG1129	ABC transporter
E4U63_RS10775	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS10780	COG1877	trehalose-phosphatase activity
E4U63_RS10790	COG0589	response to stress
E4U63_RS10805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4U63_RS10810	COG1360	Flagellar Motor Protein
E4U63_RS10815	COG0643	Histidine kinase
E4U63_RS10815	COG2198	Histidine kinase
E4U63_RS10820	COG0835	chemotaxis
E4U63_RS10825	COG0840	transmembrane signaling receptor activity
E4U63_RS10830	COG0840	transmembrane signaling receptor activity
E4U63_RS10835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4U63_RS10840	COG2201	protein-glutamate methylesterase activity
E4U63_RS10845	COG0745	RESPONSE REGULATOR receiver
E4U63_RS10855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4U63_RS10860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4U63_RS10870	COG3755	Protein conserved in bacteria
E4U63_RS10880	COG3102	Protein conserved in bacteria
E4U63_RS10890	COG3005	denitrification pathway
E4U63_RS10895	COG0243	molybdopterin cofactor binding
E4U63_RS10910	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4U63_RS10915	COG1801	Protein of unknown function DUF72
E4U63_RS10920	COG1335	isochorismatase
E4U63_RS10930	COG0494	nUDIX hydrolase
E4U63_RS10935	COG0217	transcriptional regulatory protein
E4U63_RS10965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4U63_RS10975	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4U63_RS10980	COG0739	heme binding
E4U63_RS10985	COG1560	Kdo2-lipid A biosynthetic process
E4U63_RS10990	COG0469	pyruvate kinase activity
E4U63_RS10995	COG1737	Transcriptional regulator
E4U63_RS11000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4U63_RS11005	COG0129	dihydroxy-acid dehydratase activity
E4U63_RS11010	COG0800	Aldolase
E4U63_RS11015	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4U63_RS11020	COG3141	response to X-ray
E4U63_RS11030	COG2979	Protein of unknown function (DUF533)
E4U63_RS11035	COG1770	oligopeptidase
E4U63_RS11040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS11045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U63_RS11055	COG2372	response to copper ion
E4U63_RS11060	COG1276	copper resistance
E4U63_RS11070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4U63_RS11090	COG3008	intermembrane lipid transfer
E4U63_RS11095	COG2995	paraquat-inducible protein a
E4U63_RS11100	COG1956	GAF domain-containing protein
E4U63_RS11110	COG0793	Belongs to the peptidase S41A family
E4U63_RS11120	COG2814	Major facilitator Superfamily
E4U63_RS11125	COG1414	Transcriptional regulator
E4U63_RS11155	COG2226	methyltransferase
E4U63_RS11170	COG3716	PTS system mannose fructose sorbose family IID component
E4U63_RS11175	COG3715	PTS system
E4U63_RS11180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS11180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS11185	COG1253	flavin adenine dinucleotide binding
E4U63_RS11190	COG2200	EAL domain
E4U63_RS11195	COG1760	l-serine dehydratase
E4U63_RS11205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4U63_RS11220	COG0251	oxidation-reduction process
E4U63_RS11225	COG1199	ATP-dependent helicase activity
E4U63_RS11230	COG1214	PFAM Peptidase M22, glycoprotease
E4U63_RS11235	COG3065	identical protein binding
E4U63_RS11240	COG0318	PFAM AMP-dependent synthetase and ligase
E4U63_RS11245	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4U63_RS11250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U63_RS11255	COG4638	Rieske (2fe-2S)
E4U63_RS11260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4U63_RS11265	COG0473	3-isopropylmalate dehydrogenase activity
E4U63_RS11270	COG0583	DNA-binding transcription factor activity
E4U63_RS11275	COG1280	lysine exporter protein (LysE YggA)
E4U63_RS11280	COG3615	Tellurite resistance protein tehB
E4U63_RS11290	COG2261	transglycosylase associated protein
E4U63_RS11305	COG2203	Gaf domain
E4U63_RS11305	COG2199	diguanylate cyclase activity
E4U63_RS11310	COG3042	response to heat
E4U63_RS11315	COG3189	MarR family transcriptional regulator
E4U63_RS11320	COG2807	transmembrane transport
E4U63_RS11325	COG2207	Transcriptional regulator
E4U63_RS11340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4U63_RS11345	COG2199	diguanylate cyclase activity
E4U63_RS11350	COG2199	diguanylate cyclase activity
E4U63_RS11360	COG2766	serine protein kinase
E4U63_RS11365	COG3713	MltA-interacting MipA family protein
E4U63_RS11370	COG0656	L-ascorbic acid biosynthetic process
E4U63_RS11375	COG0676	glucose-6-phosphate 1-epimerase activity
E4U63_RS11380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4U63_RS11390	COG3139	Protein of unknown function (DUF1315)
E4U63_RS11395	COG1063	alcohol dehydrogenase
E4U63_RS11400	COG2271	Major facilitator Superfamily
E4U63_RS11405	COG1063	alcohol dehydrogenase
E4U63_RS11410	COG0191	fructose-bisphosphate aldolase activity
E4U63_RS11415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS11420	COG0667	Aldo Keto reductase
E4U63_RS11425	COG1349	DNA-binding transcription factor activity
E4U63_RS11440	COG1335	isochorismatase
E4U63_RS11445	COG0252	asparaginase activity
E4U63_RS11455	COG0616	signal peptide processing
E4U63_RS11460	COG0778	Nitroreductase
E4U63_RS11465	COG0709	Synthesizes selenophosphate from selenide and ATP
E4U63_RS11470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4U63_RS11480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4U63_RS11490	COG0494	nUDIX hydrolase
E4U63_RS11495	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4U63_RS11500	COG2897	thiosulfate sulfurtransferase activity
E4U63_RS11505	COG4136	ATPase activity
E4U63_RS11510	COG4135	transport system, permease component
E4U63_RS11515	COG4134	Bacterial extracellular solute-binding protein
E4U63_RS11520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U63_RS11525	COG0398	Pfam SNARE associated Golgi protein
E4U63_RS11535	COG0398	Pfam SNARE associated Golgi protein
E4U63_RS11540	COG0708	Exodeoxyribonuclease III
E4U63_RS11570	COG3678	ATP-independent chaperone mediated protein folding
E4U63_RS11580	COG0322	excinuclease ABC activity
E4U63_RS11590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U63_RS11595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4U63_RS11600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4U63_RS11605	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4U63_RS11610	COG1917	Cupin 2, conserved barrel domain protein
E4U63_RS11610	COG2169	Transcriptional regulator
E4U63_RS11615	COG1486	melibiose metabolic process
E4U63_RS11625	COG0753	catalase activity
E4U63_RS11645	COG1988	membrane-bound metal-dependent
E4U63_RS11650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U63_RS11660	COG3001	Fructosamine kinase
E4U63_RS11670	COG1105	Belongs to the carbohydrate kinase PfkB family
E4U63_RS11675	COG3137	Salt-induced outer membrane protein
E4U63_RS11720	COG0072	phenylalanine-tRNA ligase activity
E4U63_RS11720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4U63_RS11735	COG0386	Belongs to the glutathione peroxidase family
E4U63_RS11745	COG0791	NLP P60 protein
E4U63_RS11750	COG2200	EAL domain
E4U63_RS11760	COG4256	Hemin uptake protein
E4U63_RS11765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U63_RS11775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U63_RS11775	COG0574	Belongs to the PEP-utilizing enzyme family
E4U63_RS11780	COG0318	PFAM AMP-dependent synthetase and ligase
E4U63_RS11785	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U63_RS11790	COG0644	oxidoreductase
E4U63_RS11795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4U63_RS11800	COG2086	electron transfer activity
E4U63_RS11805	COG1917	Cupin 2, conserved barrel domain protein
E4U63_RS11805	COG2207	Transcriptional regulator
E4U63_RS11810	COG1960	acyl-CoA dehydrogenase activity
E4U63_RS11815	COG4670	ketone body catabolic process
E4U63_RS11830	COG2271	Major facilitator Superfamily
E4U63_RS11835	COG0738	Major facilitator superfamily
E4U63_RS11850	COG0628	permease
E4U63_RS11855	COG0277	FAD linked oxidase domain protein
E4U63_RS11855	COG0247	lactate metabolic process
E4U63_RS11860	COG2050	protein possibly involved in aromatic compounds catabolism
E4U63_RS11870	COG0316	Belongs to the HesB IscA family
E4U63_RS11875	COG0719	Fe-S assembly protein
E4U63_RS11880	COG0396	ATPase activity
E4U63_RS11885	COG0719	Fe-S assembly protein
E4U63_RS11900	COG1376	ErfK ybiS ycfS ynhG family protein
E4U63_RS11905	COG4238	major outer membrane lipoprotein
E4U63_RS11910	COG0469	pyruvate kinase activity
E4U63_RS11920	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS11925	COG2414	aldehyde ferredoxin oxidoreductase
E4U63_RS11935	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS11940	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4U63_RS11950	COG4529	Protein conserved in bacteria
E4U63_RS11970	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS11980	COG0307	riboflavin synthase, alpha
E4U63_RS11985	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4U63_RS11990	COG2814	Major facilitator Superfamily
E4U63_RS11995	COG0583	DNA-binding transcription factor activity
E4U63_RS12010	COG2814	Major facilitator Superfamily
E4U63_RS12015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4U63_RS12020	COG0791	NLP P60 protein
E4U63_RS12025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4U63_RS12030	COG1201	RNA secondary structure unwinding
E4U63_RS12040	COG0346	lactoylglutathione lyase activity
E4U63_RS12045	COG1902	pentaerythritol trinitrate reductase activity
E4U63_RS12050	COG1309	transcriptional regulator
E4U63_RS12055	COG3313	Fe-S protein
E4U63_RS12065	COG2032	superoxide dismutase activity
E4U63_RS12075	COG1566	PFAM secretion protein HlyD family protein
E4U63_RS12090	COG3133	Outer membrane lipoprotein
E4U63_RS12100	COG3895	Periplasmic Protein
E4U63_RS12115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4U63_RS12120	COG0625	glutathione transferase activity
E4U63_RS12125	COG3104	oligopeptide transport
E4U63_RS12130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4U63_RS12140	COG4659	FMN binding
E4U63_RS12180	COG0673	inositol 2-dehydrogenase activity
E4U63_RS12190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4U63_RS12195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS12195	COG1263	PTS System
E4U63_RS12200	COG1609	Transcriptional regulator
E4U63_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS12210	COG1309	transcriptional regulator
E4U63_RS12230	COG5339	Protein conserved in bacteria
E4U63_RS12235	COG1482	cell wall glycoprotein biosynthetic process
E4U63_RS12240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS12240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS12245	COG0114	fumarate hydratase activity
E4U63_RS12255	COG2205	protein histidine kinase activity
E4U63_RS12260	COG0745	RESPONSE REGULATOR receiver
E4U63_RS12265	COG3136	membrane protein required for alginate biosynthesis
E4U63_RS12275	COG0531	amino acid
E4U63_RS12285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4U63_RS12290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4U63_RS12295	COG0628	permease
E4U63_RS12310	COG3591	Belongs to the peptidase S1B family
E4U63_RS12325	COG2814	Major facilitator Superfamily
E4U63_RS12330	COG0583	DNA-binding transcription factor activity
E4U63_RS12335	COG1940	carbohydrate kinase activity
E4U63_RS12340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4U63_RS12350	COG3381	protein complex oligomerization
E4U63_RS12355	COG3302	dmso reductase anchor subunit
E4U63_RS12360	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS12365	COG0243	molybdopterin cofactor binding
E4U63_RS12370	COG0243	molybdopterin cofactor binding
E4U63_RS12385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U63_RS12410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS12465	COG1846	Transcriptional regulator
E4U63_RS12470	COG1484	DNA-dependent DNA replication
E4U63_RS12505	COG1403	HNH endonuclease
E4U63_RS12510	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS12560	COG3772	lysozyme
E4U63_RS12700	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS12720	COG4372	Transposase
E4U63_RS12725	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS12750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS12805	COG1846	Transcriptional regulator
E4U63_RS12840	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U63_RS12850	COG1403	HNH endonuclease
E4U63_RS12855	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS12870	COG2207	Transcriptional regulator
E4U63_RS12910	COG3772	lysozyme
E4U63_RS12940	COG4220	transposase activity
E4U63_RS12960	COG1030	water channel activity
E4U63_RS13010	COG1196	nuclear chromosome segregation
E4U63_RS13045	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS13050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U63_RS13055	COG3546	catalase activity
E4U63_RS13060	COG3685	Protein conserved in bacteria
E4U63_RS13065	COG3685	Protein conserved in bacteria
E4U63_RS13070	COG3729	General stress protein
E4U63_RS13075	COG0500	methyltransferase
E4U63_RS13090	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS13095	COG4372	Transposase
E4U63_RS13105	COG4571	Outer membrane protease
E4U63_RS13115	COG0456	acetyltransferase
E4U63_RS13120	COG0538	isocitrate dehydrogenase activity
E4U63_RS13135	COG5562	phage envelope protein
E4U63_RS13140	COG0789	Transcriptional regulator
E4U63_RS13145	COG2200	EAL domain
E4U63_RS13170	COG2200	EAL domain
E4U63_RS13210	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS13210	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS13230	COG2894	cell division
E4U63_RS13260	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4U63_RS13275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4U63_RS13280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4U63_RS13285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4U63_RS13300	COG2719	SpoVR family
E4U63_RS13310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4U63_RS13320	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4U63_RS13345	COG0157	Belongs to the NadC ModD family
E4U63_RS13350	COG0500	methyltransferase
E4U63_RS13355	COG1120	ATPase activity
E4U63_RS13380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U63_RS13380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS13380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4U63_RS13385	COG1461	Dihydroxyacetone kinase
E4U63_RS13390	COG2376	Dihydroxyacetone kinase
E4U63_RS13395	COG3284	Transcriptional regulator
E4U63_RS13400	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS13405	COG0012	GTP binding
E4U63_RS13420	COG0659	secondary active sulfate transmembrane transporter activity
E4U63_RS13425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4U63_RS13455	COG3094	Invasion gene expression up-regulator, SirB
E4U63_RS13460	COG2912	Transglutaminase-like superfamily
E4U63_RS13480	COG0387	Pfam Sodium calcium exchanger
E4U63_RS13485	COG4572	Cation transport regulator
E4U63_RS13490	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4U63_RS13495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4U63_RS13500	COG4932	domain protein
E4U63_RS13505	COG2197	response regulator
E4U63_RS13510	COG3850	Histidine kinase
E4U63_RS13515	COG2223	nitrite transmembrane transporter activity
E4U63_RS13520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4U63_RS13525	COG1140	nitrate reductase beta subunit
E4U63_RS13530	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4U63_RS13535	COG2181	nitrate reductase activity
E4U63_RS13565	COG0788	formyltetrahydrofolate deformylase activity
E4U63_RS13575	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4U63_RS13580	COG0745	RESPONSE REGULATOR receiver
E4U63_RS13585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4U63_RS13595	COG1435	thymidine kinase activity
E4U63_RS13600	COG1454	alcohol dehydrogenase
E4U63_RS13600	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS13605	COG2095	MarC family integral membrane protein
E4U63_RS13610	COG4166	transmembrane transport
E4U63_RS13615	COG0601	transmembrane transport
E4U63_RS13620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U63_RS13625	COG0444	Belongs to the ABC transporter superfamily
E4U63_RS13630	COG4608	Belongs to the ABC transporter superfamily
E4U63_RS13650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4U63_RS13655	COG2350	Protein conserved in bacteria
E4U63_RS13660	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4U63_RS13665	COG1607	acyl-coa hydrolase
E4U63_RS13685	COG3047	cAMP biosynthetic process
E4U63_RS13690	COG0582	viral genome integration into host DNA
E4U63_RS13700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS13740	COG1396	sequence-specific DNA binding
E4U63_RS13765	COG1846	Transcriptional regulator
E4U63_RS13795	COG1403	HNH endonuclease
E4U63_RS13800	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS13845	COG3772	lysozyme
E4U63_RS14030	COG3842	ATPase activity
E4U63_RS14040	COG2850	peptidyl-arginine hydroxylation
E4U63_RS14130	COG4220	transposase activity
E4U63_RS14140	COG2205	protein histidine kinase activity
E4U63_RS14145	COG0745	RESPONSE REGULATOR receiver
E4U63_RS14150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4U63_RS14160	COG0482	sulfurtransferase activity
E4U63_RS14170	COG1187	pseudouridine synthase activity
E4U63_RS14175	COG0538	isocitrate dehydrogenase activity
E4U63_RS14180	COG0582	viral genome integration into host DNA
E4U63_RS14205	COG2076	Multidrug Resistance protein
E4U63_RS14215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4U63_RS14235	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS14270	COG5562	phage envelope protein
E4U63_RS14285	COG4220	transposase activity
E4U63_RS14305	COG1030	water channel activity
E4U63_RS14390	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS14420	COG0477	Major facilitator Superfamily
E4U63_RS14425	COG0246	Mannitol dehydrogenase
E4U63_RS14435	COG1802	Transcriptional regulator
E4U63_RS14440	COG4221	oxidoreductase activity
E4U63_RS14445	COG0339	signal peptide processing
E4U63_RS14450	COG1546	Belongs to the CinA family
E4U63_RS14455	COG3111	PFAM Bacterial OB fold (BOF) protein
E4U63_RS14460	COG3706	GGDEF domain
E4U63_RS14480	COG2814	Major facilitator Superfamily
E4U63_RS14485	COG0697	spore germination
E4U63_RS14495	COG4977	sequence-specific DNA binding
E4U63_RS14500	COG1846	Transcriptional regulator
E4U63_RS14505	COG2095	MarC family integral membrane protein
E4U63_RS14510	COG2814	Major facilitator Superfamily
E4U63_RS14520	COG0583	DNA-binding transcription factor activity
E4U63_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS14530	COG2066	Belongs to the glutaminase family
E4U63_RS14540	COG2199	diguanylate cyclase activity
E4U63_RS14550	COG3781	membrane
E4U63_RS14565	COG1830	Aldolase
E4U63_RS14575	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS14580	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS14585	COG1129	ABC transporter
E4U63_RS14595	COG1070	Carbohydrate kinase
E4U63_RS14615	COG3539	Fimbrial protein
E4U63_RS14625	COG3188	usher protein
E4U63_RS14630	COG3539	Fimbrial protein
E4U63_RS14635	COG3539	Fimbrial protein
E4U63_RS14640	COG3539	Fimbrial protein
E4U63_RS14645	COG0243	molybdopterin cofactor binding
E4U63_RS14655	COG2207	Transcriptional regulator
E4U63_RS14660	COG3119	arylsulfatase activity
E4U63_RS14665	COG0641	radical SAM
E4U63_RS14675	COG4178	(ABC) transporter
E4U63_RS14680	COG4771	TonB-dependent receptor
E4U63_RS14685	COG0612	Peptidase, M16
E4U63_RS14690	COG0076	glutamate decarboxylase activity
E4U63_RS14695	COG0531	amino acid
E4U63_RS14705	COG3706	GGDEF domain
E4U63_RS14710	COG2199	diguanylate cyclase activity
E4U63_RS14710	COG2200	EAL domain
E4U63_RS14710	COG2202	Pas domain
E4U63_RS14715	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4U63_RS14720	COG0747	negative chemotaxis
E4U63_RS14730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4U63_RS14735	COG0444	Belongs to the ABC transporter superfamily
E4U63_RS14740	COG4608	Belongs to the ABC transporter superfamily
E4U63_RS14745	COG1764	response to oxidative stress
E4U63_RS14765	COG1064	alcohol dehydrogenase
E4U63_RS14770	COG3093	addiction module antidote protein HigA
E4U63_RS14775	COG2864	formate dehydrogenase
E4U63_RS14780	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS14790	COG0697	spore germination
E4U63_RS14805	COG4886	Leucine-rich repeat (LRR) protein
E4U63_RS14810	COG4886	Leucine-rich repeat (LRR) protein
E4U63_RS14815	COG2223	nitrite transmembrane transporter activity
E4U63_RS14820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4U63_RS14825	COG1140	nitrate reductase beta subunit
E4U63_RS14830	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4U63_RS14835	COG2181	nitrate reductase activity
E4U63_RS14840	COG0384	phenazine biosynthesis protein PhzF
E4U63_RS14850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4U63_RS14880	COG3501	Rhs element vgr protein
E4U63_RS14890	COG0625	glutathione transferase activity
E4U63_RS14895	COG1113	amino acid transport
E4U63_RS14900	COG3391	amine dehydrogenase activity
E4U63_RS14905	COG4772	TonB-dependent receptor
E4U63_RS14910	COG1802	Transcriptional regulator
E4U63_RS14915	COG2130	NADP-dependent
E4U63_RS14920	COG1247	-acetyltransferase
E4U63_RS14925	COG3238	Protein conserved in bacteria
E4U63_RS14950	COG1177	transmembrane transport
E4U63_RS14955	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4U63_RS14960	COG3842	ATPase activity
E4U63_RS14965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U63_RS14970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4U63_RS14975	COG1598	PFAM Uncharacterised protein family UPF0150
E4U63_RS14980	COG1724	mRNA binding
E4U63_RS14990	COG0826	peptidase U32
E4U63_RS14995	COG1396	sequence-specific DNA binding
E4U63_RS15000	COG3135	benzoate transporter
E4U63_RS15010	COG0500	methyltransferase
E4U63_RS15015	COG1275	C4-dicarboxylate transporter malic acid transport protein
E4U63_RS15020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4U63_RS15030	COG2841	Protein conserved in bacteria
E4U63_RS15040	COG5383	Protein conserved in bacteria
E4U63_RS15045	COG0583	DNA-binding transcription factor activity
E4U63_RS15050	COG0840	transmembrane signaling receptor activity
E4U63_RS15065	COG3038	cytochrome b561
E4U63_RS15070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4U63_RS15075	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS15080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4U63_RS15105	COG1643	Atp-dependent helicase
E4U63_RS15110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4U63_RS15115	COG0671	phosphoesterase, PA-phosphatase related
E4U63_RS15115	COG2453	phosphatase
E4U63_RS15125	COG4589	Belongs to the CDS family
E4U63_RS15130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4U63_RS15140	COG0667	Aldo Keto reductase
E4U63_RS15155	COG3784	Protein of unknown function (DUF1318)
E4U63_RS15165	COG2911	Protein conserved in bacteria
E4U63_RS15170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4U63_RS15175	COG3187	Heat shock protein
E4U63_RS15180	COG3042	response to heat
E4U63_RS15185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4U63_RS15185	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4U63_RS15185	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4U63_RS15185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4U63_RS15195	COG0589	response to stress
E4U63_RS15205	COG0513	Belongs to the DEAD box helicase family
E4U63_RS15220	COG3706	GGDEF domain
E4U63_RS15225	COG2840	Smr protein MutS2
E4U63_RS15230	COG0583	DNA-binding transcription factor activity
E4U63_RS15235	COG1473	amidohydrolase
E4U63_RS15240	COG1473	amidohydrolase
E4U63_RS15245	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4U63_RS15250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4U63_RS15255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U63_RS15260	COG0589	response to stress
E4U63_RS15265	COG3182	Iron-regulated membrane protein
E4U63_RS15270	COG0668	transmembrane transport
E4U63_RS15275	COG4166	transmembrane transport
E4U63_RS15280	COG0583	DNA-binding transcription factor activity
E4U63_RS15285	COG1073	alpha beta
E4U63_RS15295	COG0702	epimerase
E4U63_RS15300	COG2866	Carboxypeptidase
E4U63_RS15305	COG4948	Mandelate Racemase Muconate Lactonizing
E4U63_RS15310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4U63_RS15315	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E4U63_RS15325	COG3106	COG3106 Predicted ATPase
E4U63_RS15330	COG1609	Transcriptional regulator
E4U63_RS15340	COG3842	ATPase activity
E4U63_RS15345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4U63_RS15350	COG1554	hydrolase, family 65, central catalytic
E4U63_RS15355	COG0673	inositol 2-dehydrogenase activity
E4U63_RS15360	COG1082	Xylose isomerase domain protein TIM barrel
E4U63_RS15365	COG1063	alcohol dehydrogenase
E4U63_RS15370	COG0395	ABC-type sugar transport system, permease component
E4U63_RS15375	COG1175	transmembrane transport
E4U63_RS15390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4U63_RS15400	COG1983	PspC domain protein
E4U63_RS15410	COG1842	Phage shock protein A
E4U63_RS15415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4U63_RS15420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4U63_RS15425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4U63_RS15430	COG1012	belongs to the aldehyde dehydrogenase family
E4U63_RS15435	COG1917	Cupin 2, conserved barrel domain protein
E4U63_RS15435	COG1396	sequence-specific DNA binding
E4U63_RS15440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4U63_RS15445	COG0174	glutamine synthetase
E4U63_RS15455	COG0531	amino acid
E4U63_RS15465	COG4166	transmembrane transport
E4U63_RS15470	COG4168	peptide transport system, permease
E4U63_RS15475	COG4171	peptide transport system, permease
E4U63_RS15480	COG4172	Belongs to the ABC transporter superfamily
E4U63_RS15485	COG4172	Belongs to the ABC transporter superfamily
E4U63_RS15490	COG2814	Major facilitator Superfamily
E4U63_RS15520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4U63_RS15525	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U63_RS15525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4U63_RS15535	COG5001	Diguanylate cyclase
E4U63_RS15545	COG1349	DNA-binding transcription factor activity
E4U63_RS15555	COG0023	Translation Initiation Factor
E4U63_RS15565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4U63_RS15570	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E4U63_RS15575	COG0671	phosphoesterase, PA-phosphatase related
E4U63_RS15585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4U63_RS15605	COG0583	DNA-binding transcription factor activity
E4U63_RS15610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4U63_RS15620	COG0616	signal peptide processing
E4U63_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS15630	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4U63_RS15635	COG1187	pseudouridine synthase activity
E4U63_RS15655	COG0009	L-threonylcarbamoyladenylate synthase
E4U63_RS15660	COG0613	PHP domain protein
E4U63_RS15670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4U63_RS15675	COG0512	Glutamine amidotransferase of anthranilate synthase
E4U63_RS15675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4U63_RS15680	COG0135	phosphoribosylanthranilate isomerase activity
E4U63_RS15680	COG0134	indole-3-glycerol-phosphate synthase activity
E4U63_RS15695	COG3729	General stress protein
E4U63_RS15700	COG3685	Protein conserved in bacteria
E4U63_RS15705	COG3685	Protein conserved in bacteria
E4U63_RS15755	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS15760	COG4372	Transposase
E4U63_RS15805	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS15935	COG3772	lysozyme
E4U63_RS15975	COG0484	heat shock protein binding
E4U63_RS15980	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS15985	COG1403	HNH endonuclease
E4U63_RS16040	COG1846	Transcriptional regulator
E4U63_RS16060	COG4197	protein conserved in bacteria, prophage-related
E4U63_RS16100	COG0582	viral genome integration into host DNA
E4U63_RS16105	COG1177	transmembrane transport
E4U63_RS16110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U63_RS16115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4U63_RS16125	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4U63_RS16130	COG1136	(ABC) transporter
E4U63_RS16135	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4U63_RS16140	COG4763	Acyl-transferase
E4U63_RS16145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4U63_RS16150	COG1388	LysM domain
E4U63_RS16150	COG1376	ErfK ybiS ycfS ynhG family protein
E4U63_RS16160	COG1309	transcriptional regulator
E4U63_RS16165	COG3134	Outer membrane lipoprotein
E4U63_RS16170	COG1252	NADH dehydrogenase
E4U63_RS16185	COG0510	thiamine kinase activity
E4U63_RS16190	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E4U63_RS16195	COG5633	Lipoprotein
E4U63_RS16200	COG0537	adenosine 5'-monophosphoramidase activity
E4U63_RS16210	COG4773	Receptor
E4U63_RS16215	COG1263	PTS System
E4U63_RS16215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS16220	COG0084	hydrolase, TatD family'
E4U63_RS16225	COG0470	DNA polymerase III
E4U63_RS16235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4U63_RS16240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4U63_RS16245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U63_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS16260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4U63_RS16280	COG1399	metal-binding, possibly nucleic acid-binding protein
E4U63_RS16285	COG0424	maF-like protein
E4U63_RS16290	COG0564	pseudouridine synthase activity
E4U63_RS16295	COG1530	ribonuclease E activity
E4U63_RS16300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4U63_RS16305	COG1256	bacterial-type flagellum assembly
E4U63_RS16310	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4U63_RS16310	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4U63_RS16325	COG4786	Flagellar basal body rod
E4U63_RS16330	COG4787	bacterial-type flagellum-dependent cell motility
E4U63_RS16335	COG1749	Flagellar hook protein flgE
E4U63_RS16340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4U63_RS16345	COG1558	bacterial-type flagellum-dependent cell motility
E4U63_RS16350	COG1815	bacterial-type flagellum-dependent cell motility
E4U63_RS16355	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4U63_RS16360	COG2747	anti-sigma28 factor FlgM
E4U63_RS16365	COG3418	PFAM FlgN family protein
E4U63_RS16370	COG0728	peptidoglycan biosynthetic process
E4U63_RS16375	COG0673	inositol 2-dehydrogenase activity
E4U63_RS16385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4U63_RS16395	COG2999	glutathione oxidoreductase activity
E4U63_RS16430	COG3038	cytochrome b561
E4U63_RS16435	COG2353	YceI-like domain
E4U63_RS16445	COG1560	Kdo2-lipid A biosynthetic process
E4U63_RS16460	COG5645	(Lipo)protein
E4U63_RS16465	COG2943	transferase activity, transferring hexosyl groups
E4U63_RS16480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U63_RS16485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4U63_RS16510	COG2197	response regulator
E4U63_RS16525	COG1462	curli production assembly transport component CsgG
E4U63_RS16535	COG3381	protein complex oligomerization
E4U63_RS16585	COG2003	Belongs to the UPF0758 family
E4U63_RS16660	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E4U63_RS16670	COG2831	hemolysin activation secretion protein
E4U63_RS16755	COG4771	TonB-dependent receptor
E4U63_RS16815	COG1358	cellular component organization or biogenesis
E4U63_RS16850	COG4372	Transposase
E4U63_RS16855	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS16895	COG4372	Transposase
E4U63_RS16900	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS16940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4U63_RS16945	COG2194	sulfuric ester hydrolase activity
E4U63_RS16955	COG0829	nickel cation binding
E4U63_RS17000	COG0254	rRNA binding
E4U63_RS17035	COG4983	Phage plasmid primase, P4 family domain protein
E4U63_RS17060	COG0582	viral genome integration into host DNA
E4U63_RS17110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4U63_RS17115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4U63_RS17125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4U63_RS17135	COG0736	holo-[acyl-carrier-protein] synthase activity
E4U63_RS17140	COG2831	hemolysin activation secretion protein
E4U63_RS17145	COG3210	domain, Protein
E4U63_RS17155	COG3539	Fimbrial protein
E4U63_RS17165	COG3188	usher protein
E4U63_RS17175	COG3121	Chaperone
E4U63_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS17185	COG3710	Transcriptional regulator
E4U63_RS17195	COG2200	EAL domain
E4U63_RS17200	COG3706	GGDEF domain
E4U63_RS17205	COG0457	Tetratricopeptide repeat
E4U63_RS17210	COG0726	polysaccharide deacetylase
E4U63_RS17210	COG1649	PFAM Uncharacterised BCR, COG1649
E4U63_RS17215	COG1215	transferase activity, transferring glycosyl groups
E4U63_RS17220	COG3658	cytochrome
E4U63_RS17225	COG1702	phosphate starvation-inducible protein PhoH
E4U63_RS17230	COG2837	iron assimilation
E4U63_RS17235	COG2822	iron ion transport
E4U63_RS17250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4U63_RS17260	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U63_RS17260	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U63_RS17260	COG0506	proline dehydrogenase activity
E4U63_RS17265	COG1309	transcriptional regulator
E4U63_RS17300	COG2233	PERMEase
E4U63_RS17305	COG3729	General stress protein
E4U63_RS17345	COG0243	molybdopterin cofactor binding
E4U63_RS17350	COG3005	denitrification pathway
E4U63_RS17355	COG0745	RESPONSE REGULATOR receiver
E4U63_RS17360	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS17365	COG0784	Response regulator, receiver
E4U63_RS17365	COG2198	Histidine kinase
E4U63_RS17365	COG2205	protein histidine kinase activity
E4U63_RS17370	COG0348	domain, Protein
E4U63_RS17390	COG1278	Cold shock
E4U63_RS17395	COG1278	Cold shock
E4U63_RS17415	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U63_RS17420	COG1596	polysaccharide export
E4U63_RS17425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4U63_RS17430	COG0489	protein tyrosine kinase activity
E4U63_RS17430	COG3206	protein involved in exopolysaccharide biosynthesis
E4U63_RS17445	COG1294	oxidase, subunit
E4U63_RS17450	COG1271	oxidase subunit
E4U63_RS17455	COG1773	rubredoxin
E4U63_RS17460	COG1999	signal sequence binding
E4U63_RS17465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4U63_RS17470	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E4U63_RS17475	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4U63_RS17480	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4U63_RS17500	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS17515	COG2032	superoxide dismutase activity
E4U63_RS17595	COG4372	Transposase
E4U63_RS17600	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS17635	COG3772	lysozyme
E4U63_RS17685	COG2207	Transcriptional regulator
E4U63_RS17705	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4U63_RS17710	COG1403	HNH endonuclease
E4U63_RS17740	COG1846	Transcriptional regulator
E4U63_RS17745	COG1484	DNA-dependent DNA replication
E4U63_RS17810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS17825	COG0670	Belongs to the BI1 family
E4U63_RS17830	COG2920	part of a sulfur-relay system
E4U63_RS17835	COG1254	Belongs to the acylphosphatase family
E4U63_RS17850	COG1832	CoA-binding protein
E4U63_RS17865	COG0210	DNA helicase
E4U63_RS17870	COG3304	Inner membrane component domain
E4U63_RS17875	COG1289	transmembrane transporter activity
E4U63_RS17880	COG3070	regulator of competence-specific genes
E4U63_RS17890	COG2885	chlorophyll binding
E4U63_RS17890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4U63_RS17900	COG1067	ATP-dependent peptidase activity
E4U63_RS17910	COG3130	regulation of translation
E4U63_RS17915	COG3009	Protein conserved in bacteria
E4U63_RS17920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4U63_RS17920	COG3008	intermembrane lipid transfer
E4U63_RS17925	COG2995	paraquat-inducible protein a
E4U63_RS17930	COG0488	(ABC) transporter
E4U63_RS17940	COG3217	Mosc domain protein beta barrel domain protein
E4U63_RS17940	COG0633	Ferredoxin
E4U63_RS17960	COG3539	Fimbrial protein
E4U63_RS17965	COG3539	Fimbrial protein
E4U63_RS17970	COG3539	Fimbrial protein
E4U63_RS17980	COG3121	Chaperone
E4U63_RS17985	COG3539	Fimbrial protein
E4U63_RS17990	COG0431	NADPH-dependent FMN reductase
E4U63_RS17995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4U63_RS18005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4U63_RS18010	COG1116	anion transmembrane transporter activity
E4U63_RS18015	COG0308	aminopeptidase N
E4U63_RS18025	COG0017	Asparaginyl-tRNA synthetase
E4U63_RS18030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U63_RS18035	COG1448	Aminotransferase
E4U63_RS18040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4U63_RS18045	COG3108	Peptidase M15
E4U63_RS18050	COG2989	Protein conserved in bacteria
E4U63_RS18060	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4U63_RS18070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4U63_RS18075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4U63_RS18080	COG3173	Aminoglycoside phosphotransferase
E4U63_RS18095	COG3214	Protein conserved in bacteria
E4U63_RS18105	COG1132	(ABC) transporter
E4U63_RS18110	COG0658	competence protein
E4U63_RS18110	COG2333	competence protein COMEC
E4U63_RS18120	COG0539	negative regulation of cytoplasmic translation
E4U63_RS18130	COG0501	Belongs to the peptidase M48B family
E4U63_RS18145	COG2323	membrane
E4U63_RS18150	COG1944	ATP diphosphatase activity
E4U63_RS18155	COG2116	formate transmembrane transporter activity
E4U63_RS18160	COG1882	Formate acetyltransferase
E4U63_RS18165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U63_RS18175	COG0531	amino acid
E4U63_RS18185	COG1335	isochorismatase
E4U63_RS18190	COG3302	dmso reductase anchor subunit
E4U63_RS18195	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS18200	COG0243	molybdopterin cofactor binding
E4U63_RS18210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4U63_RS18220	COG1674	ftsk spoiiie
E4U63_RS18220	COG1178	ABC-type Fe3 transport system permease component
E4U63_RS18225	COG1522	sequence-specific DNA binding
E4U63_RS18230	COG0492	ferredoxin-NADP+ reductase activity
E4U63_RS18235	COG4988	ABC transporter
E4U63_RS18240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4U63_RS18260	COG0542	response to heat
E4U63_RS18270	COG1278	Cold shock
E4U63_RS18275	COG1136	(ABC) transporter
E4U63_RS18275	COG0577	efflux transmembrane transporter activity
E4U63_RS18280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS18285	COG2990	Protein conserved in bacteria
E4U63_RS18290	COG3593	DNA synthesis involved in DNA repair
E4U63_RS18295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4U63_RS18300	COG2431	L-lysine efflux transmembrane transporter activity
E4U63_RS18310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4U63_RS18315	COG0028	Belongs to the TPP enzyme family
E4U63_RS18320	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4U63_RS18325	COG0702	epimerase
E4U63_RS18330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4U63_RS18335	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4U63_RS18355	COG1126	abc transporter atp-binding protein
E4U63_RS18360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS18365	COG4215	(ABC) transporter
E4U63_RS18370	COG4160	amino acid transport
E4U63_RS18375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS18405	COG1177	transmembrane transport
E4U63_RS18410	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4U63_RS18415	COG3842	ATPase activity
E4U63_RS18420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4U63_RS18435	COG0778	Nitroreductase
E4U63_RS18445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4U63_RS18460	COG3226	Transcriptional regulator
E4U63_RS18465	COG0738	Major facilitator superfamily
E4U63_RS18470	COG0561	phosphatase activity
E4U63_RS18485	COG0671	phosphoesterase, PA-phosphatase related
E4U63_RS18490	COG1349	DNA-binding transcription factor activity
E4U63_RS18495	COG1686	Belongs to the peptidase S11 family
E4U63_RS18500	COG0625	glutathione transferase activity
E4U63_RS18505	COG2133	pyrroloquinoline quinone binding
E4U63_RS18530	COG2199	diguanylate cyclase activity
E4U63_RS18535	COG2200	EAL domain
E4U63_RS18545	COG0601	transmembrane transport
E4U63_RS18550	COG0747	negative chemotaxis
E4U63_RS18555	COG4172	Belongs to the ABC transporter superfamily
E4U63_RS18565	COG0303	'Molybdopterin
E4U63_RS18570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4U63_RS18575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U63_RS18580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U63_RS18590	COG0561	phosphatase activity
E4U63_RS18600	COG0488	(ABC) transporter
E4U63_RS18605	COG1376	ErfK ybiS ycfS ynhG family protein
E4U63_RS18610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4U63_RS18615	COG1321	iron dependent repressor
E4U63_RS18625	COG2194	sulfuric ester hydrolase activity
E4U63_RS18630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4U63_RS18640	COG5006	permease, DMT superfamily
E4U63_RS18650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS18655	COG0765	amino acid transport
E4U63_RS18660	COG1126	abc transporter atp-binding protein
E4U63_RS18665	COG0668	transmembrane transport
E4U63_RS18680	COG4774	siderophore transport
E4U63_RS18690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4U63_RS18700	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4U63_RS18705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4U63_RS18710	COG1199	ATP-dependent helicase activity
E4U63_RS18720	COG0513	Belongs to the DEAD box helicase family
E4U63_RS18725	COG1309	transcriptional regulator
E4U63_RS18735	COG1131	(ABC) transporter
E4U63_RS18740	COG0842	Transport permease protein
E4U63_RS18745	COG0842	Transport permease protein
E4U63_RS18755	COG3568	Endonuclease Exonuclease Phosphatase
E4U63_RS18760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4U63_RS18765	COG0392	lysyltransferase activity
E4U63_RS18770	COG0670	Belongs to the BI1 family
E4U63_RS18775	COG0670	Belongs to the BI1 family
E4U63_RS18780	COG0314	molybdopterin synthase activity
E4U63_RS18785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4U63_RS18795	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4U63_RS18805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4U63_RS18815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4U63_RS18820	COG2226	methyltransferase
E4U63_RS18835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4U63_RS18840	COG1881	PFAM PEBP family protein
E4U63_RS18880	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS18920	COG3772	lysozyme
E4U63_RS19040	COG0582	viral genome integration into host DNA
E4U63_RS19045	COG4677	pectinesterase activity
E4U63_RS19050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4U63_RS19055	COG0471	metal ion transport
E4U63_RS19060	COG2828	Protein conserved in bacteria
E4U63_RS19065	COG0583	DNA-binding transcription factor activity
E4U63_RS19075	COG0561	phosphatase activity
E4U63_RS19085	COG4149	molybdate abc transporter
E4U63_RS19090	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4U63_RS19100	COG3585	molybdate ion transport
E4U63_RS19100	COG2005	Transcriptional regulator
E4U63_RS19105	COG1119	ATPase activity
E4U63_RS19110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4U63_RS19115	COG1085	galactose-1-phosphate uridylyltransferase
E4U63_RS19125	COG2017	converts alpha-aldose to the beta-anomer
E4U63_RS19135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4U63_RS19145	COG1230	cation diffusion facilitator family transporter
E4U63_RS19150	COG3201	nicotinamide mononucleotide transporter
E4U63_RS19155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4U63_RS19190	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4U63_RS19195	COG2885	chlorophyll binding
E4U63_RS19205	COG3064	Membrane
E4U63_RS19210	COG0848	biopolymer transport protein
E4U63_RS19215	COG0811	peptide transport
E4U63_RS19220	COG0824	Thioesterase
E4U63_RS19225	COG3790	cyd operon protein YbgE
E4U63_RS19230	COG4890	Cyd operon protein YbgT
E4U63_RS19235	COG1294	oxidase, subunit
E4U63_RS19240	COG1271	oxidase subunit
E4U63_RS19255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4U63_RS19265	COG4865	methylaspartate mutase activity
E4U63_RS19270	COG3799	methylaspartate ammonia-lyase activity
E4U63_RS19285	COG1301	dicarboxylic acid transport
E4U63_RS19290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS19290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS19295	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E4U63_RS19300	COG0583	DNA-binding transcription factor activity
E4U63_RS19305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U63_RS19315	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4U63_RS19320	COG0567	Dehydrogenase, E1 component
E4U63_RS19325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4U63_RS19330	COG1053	succinate dehydrogenase
E4U63_RS19335	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4U63_RS19340	COG2009	succinate dehydrogenase
E4U63_RS19350	COG0372	Belongs to the citrate synthase family
E4U63_RS19355	COG3539	Fimbrial protein
E4U63_RS19360	COG3188	usher protein
E4U63_RS19365	COG3121	Chaperone
E4U63_RS19370	COG3539	Fimbrial protein
E4U63_RS19375	COG3180	Ammonia monooxygenase
E4U63_RS19380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4U63_RS19390	COG1984	allophanate hydrolase subunit 2
E4U63_RS19395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4U63_RS19400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4U63_RS19405	COG3104	oligopeptide transport
E4U63_RS19410	COG0415	Belongs to the DNA photolyase family
E4U63_RS19415	COG3272	Protein of unknown function (DUF1722)
E4U63_RS19420	COG5433	transposase activity
E4U63_RS19435	COG3209	COG3209 Rhs family protein
E4U63_RS19465	COG2205	protein histidine kinase activity
E4U63_RS19470	COG0745	RESPONSE REGULATOR receiver
E4U63_RS19480	COG1982	Orn Lys Arg decarboxylase major
E4U63_RS19485	COG0531	amino acid
E4U63_RS19490	COG0033	Phosphoglucomutase
E4U63_RS19495	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4U63_RS19500	COG0596	Alpha beta hydrolase
E4U63_RS19510	COG0716	FMN binding
E4U63_RS19520	COG0735	belongs to the Fur family
E4U63_RS19540	COG1263	PTS System
E4U63_RS19540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS19540	COG2190	(PTS) system
E4U63_RS19550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U63_RS19555	COG1940	carbohydrate kinase activity
E4U63_RS19555	COG1846	Transcriptional regulator
E4U63_RS19560	COG0647	UMP catabolic process
E4U63_RS19565	COG0367	asparagine synthase
E4U63_RS19605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4U63_RS19615	COG1702	phosphate starvation-inducible protein PhoH
E4U63_RS19625	COG4535	Mg2 and Co2 transporter CorC
E4U63_RS19630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4U63_RS19635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4U63_RS19640	COG0765	amino acid transport
E4U63_RS19645	COG0765	amino acid transport
E4U63_RS19650	COG1126	abc transporter atp-binding protein
E4U63_RS19660	COG0443	Heat shock 70 kDa protein
E4U63_RS19675	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U63_RS19680	COG2214	Heat shock protein DnaJ domain protein
E4U63_RS19695	COG2888	peptidyl-tyrosine sulfation
E4U63_RS19710	COG1466	dna polymerase III delta subunit
E4U63_RS19720	COG0406	alpha-ribazole phosphatase activity
E4U63_RS19725	COG0799	negative regulation of ribosome biogenesis
E4U63_RS19735	COG0768	penicillin binding
E4U63_RS19740	COG0772	Belongs to the SEDS family
E4U63_RS19745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4U63_RS19750	COG1686	Belongs to the peptidase S11 family
E4U63_RS19765	COG0583	DNA-binding transcription factor activity
E4U63_RS19775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U63_RS19780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U63_RS19800	COG3069	C4-dicarboxylate transmembrane transporter activity
E4U63_RS19805	COG4565	transcriptional regulatory protein
E4U63_RS19810	COG3290	protein histidine kinase activity
E4U63_RS19815	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4U63_RS19825	COG2301	Belongs to the HpcH HpaI aldolase family
E4U63_RS19830	COG3051	citrate lyase alpha subunit
E4U63_RS19840	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4U63_RS19845	COG0471	metal ion transport
E4U63_RS19850	COG3719	Belongs to the RNase T2 family
E4U63_RS19855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4U63_RS19860	COG1063	alcohol dehydrogenase
E4U63_RS19865	COG0589	response to stress
E4U63_RS19870	COG3634	alkyl hydroperoxide reductase activity
E4U63_RS19875	COG0450	alkyl hydroperoxide reductase
E4U63_RS19880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U63_RS19885	COG0583	DNA-binding transcription factor activity
E4U63_RS19890	COG3969	phosphoadenosine phosphosulfate
E4U63_RS19895	COG1475	DNA binding
E4U63_RS19900	COG0436	Aminotransferase
E4U63_RS19905	COG0371	Dehydrogenase
E4U63_RS19910	COG2879	small protein
E4U63_RS19915	COG1966	Carbon starvation protein
E4U63_RS19925	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS19930	COG1535	isochorismatase
E4U63_RS19930	COG3433	isochorismatase activity
E4U63_RS19935	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4U63_RS19940	COG1169	isochorismate synthase
E4U63_RS19945	COG4592	Periplasmic binding protein
E4U63_RS19955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U63_RS19960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U63_RS19965	COG1120	ATPase activity
E4U63_RS19970	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4U63_RS19975	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E4U63_RS19975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4U63_RS19980	COG3251	PFAM MbtH domain protein
E4U63_RS19985	COG2382	esterase
E4U63_RS19990	COG4771	TonB-dependent receptor
E4U63_RS19995	COG2977	Belongs to the P-Pant transferase superfamily
E4U63_RS20020	COG2315	Protein conserved in bacteria
E4U63_RS20025	COG0778	Nitroreductase
E4U63_RS20030	COG0668	transmembrane transport
E4U63_RS20035	COG1113	amino acid transport
E4U63_RS20040	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U63_RS20045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS20050	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS20055	COG1538	Outer membrane efflux protein
E4U63_RS20060	COG0745	RESPONSE REGULATOR receiver
E4U63_RS20065	COG5002	protein histidine kinase activity
E4U63_RS20070	COG3501	Rhs element vgr protein
E4U63_RS20080	COG3209	COG3209 Rhs family protein
E4U63_RS20080	COG4104	PAAR repeat-containing protein
E4U63_RS20090	COG3209	COG3209 Rhs family protein
E4U63_RS20090	COG4104	PAAR repeat-containing protein
E4U63_RS20100	COG5433	transposase activity
E4U63_RS20105	COG1215	transferase activity, transferring glycosyl groups
E4U63_RS20110	COG4783	chaperone-mediated protein folding
E4U63_RS20120	COG2207	Transcriptional regulator
E4U63_RS20130	COG2197	response regulator
E4U63_RS20135	COG3539	Fimbrial protein
E4U63_RS20140	COG3539	Fimbrial protein
E4U63_RS20145	COG3188	usher protein
E4U63_RS20150	COG3121	Chaperone
E4U63_RS20155	COG3539	Fimbrial protein
E4U63_RS20165	COG2501	S4 domain
E4U63_RS20170	COG1988	membrane-bound metal-dependent
E4U63_RS20180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4U63_RS20190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4U63_RS20195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4U63_RS20200	COG0549	Belongs to the carbamate kinase family
E4U63_RS20210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U63_RS20215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U63_RS20225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4U63_RS20230	COG3257	ureidoglycine aminohydrolase activity
E4U63_RS20235	COG1929	Belongs to the glycerate kinase type-1 family
E4U63_RS20240	COG2233	PERMEase
E4U63_RS20250	COG1953	Uracil, thiamine, allantoin
E4U63_RS20255	COG2084	Dehydrogenase
E4U63_RS20260	COG3622	Belongs to the hyi family
E4U63_RS20265	COG3960	tartronate-semialdehyde synthase activity
E4U63_RS20270	COG1414	Transcriptional regulator
E4U63_RS20280	COG0583	DNA-binding transcription factor activity
E4U63_RS20300	COG3209	COG3209 Rhs family protein
E4U63_RS20305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4U63_RS20310	COG4181	ATPase activity
E4U63_RS20315	COG2755	lipolytic protein G-D-S-L family
E4U63_RS20320	COG0300	oxidoreductase activity
E4U63_RS20325	COG3118	belongs to the thioredoxin family
E4U63_RS20330	COG0390	transport system, permease component
E4U63_RS20335	COG4619	ABC transporter
E4U63_RS20340	COG0330	HflC and HflK could
E4U63_RS20345	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4U63_RS20365	COG0789	Transcriptional regulator
E4U63_RS20390	COG0531	amino acid
E4U63_RS20395	COG2066	Belongs to the glutaminase family
E4U63_RS20400	COG2217	Heavy metal translocating P-type atpase
E4U63_RS20405	COG3093	addiction module antidote protein HigA
E4U63_RS20410	COG3735	TraB family
E4U63_RS20415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4U63_RS20420	COG0737	Belongs to the 5'-nucleotidase family
E4U63_RS20425	COG2223	nitrite transmembrane transporter activity
E4U63_RS20430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4U63_RS20430	COG4651	solute:proton antiporter activity
E4U63_RS20435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS20470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4U63_RS20480	COG2832	Protein of unknown function (DUF454)
E4U63_RS20485	COG3923	Primosomal replication protein n
E4U63_RS20495	COG3264	Mechanosensitive ion channel
E4U63_RS20495	COG1196	nuclear chromosome segregation
E4U63_RS20500	COG1309	transcriptional regulator
E4U63_RS20505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4U63_RS20510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4U63_RS20525	COG0110	maltose O-acetyltransferase activity
E4U63_RS20535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4U63_RS20540	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4U63_RS20550	COG3695	enzyme binding
E4U63_RS20555	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E4U63_RS20560	COG1946	Acyl-CoA thioesterase
E4U63_RS20565	COG0004	ammonium transporteR
E4U63_RS20570	COG0347	Belongs to the P(II) protein family
E4U63_RS20575	COG1132	(ABC) transporter
E4U63_RS20580	COG1132	(ABC) transporter
E4U63_RS20585	COG1522	sequence-specific DNA binding
E4U63_RS20595	COG4533	DNA binding
E4U63_RS20605	COG0824	Thioesterase
E4U63_RS20610	COG1555	photosystem II stabilization
E4U63_RS20615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U63_RS20620	COG0776	regulation of translation
E4U63_RS20625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4U63_RS20645	COG0271	Belongs to the BolA IbaG family
E4U63_RS20650	COG3056	Lipoprotein
E4U63_RS20655	COG2223	nitrite transmembrane transporter activity
E4U63_RS20660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4U63_RS20665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4U63_RS20670	COG1845	cytochrome c oxidase, subunit III
E4U63_RS20675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4U63_RS20685	COG2814	Major facilitator Superfamily
E4U63_RS20695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4U63_RS20700	COG0693	protein deglycase activity
E4U63_RS20715	COG0142	geranyltranstransferase activity
E4U63_RS20725	COG0667	Aldo Keto reductase
E4U63_RS20735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4U63_RS20740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4U63_RS20755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4U63_RS20755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4U63_RS20765	COG4238	major outer membrane lipoprotein
E4U63_RS20770	COG3248	Nucleoside-binding outer membrane protein
E4U63_RS20775	COG1403	HNH endonuclease
E4U63_RS20785	COG3609	addiction module antidote protein, CC2985 family
E4U63_RS20790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4U63_RS20795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4U63_RS20800	COG1862	Preprotein translocase
E4U63_RS20825	COG0366	Alpha amylase catalytic
E4U63_RS20830	COG1113	amino acid transport
E4U63_RS20835	COG1114	Component of the transport system for branched-chain amino acids
E4U63_RS20840	COG5002	protein histidine kinase activity
E4U63_RS20845	COG0745	RESPONSE REGULATOR receiver
E4U63_RS20850	COG0420	3'-5' exonuclease activity
E4U63_RS20855	COG0419	ATPase involved in DNA repair
E4U63_RS20860	COG2814	Major facilitator Superfamily
E4U63_RS20865	COG1940	carbohydrate kinase activity
E4U63_RS20890	COG4126	flavin adenine dinucleotide binding
E4U63_RS20910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4U63_RS20915	COG3706	GGDEF domain
E4U63_RS20925	COG1785	Belongs to the alkaline phosphatase family
E4U63_RS20940	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4U63_RS20960	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4U63_RS20965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U63_RS20970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4U63_RS20975	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS20980	COG0113	porphobilinogen synthase activity
E4U63_RS20985	COG2175	clavaminate synthase activity
E4U63_RS20990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4U63_RS20995	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4U63_RS21000	COG4521	taurine ABC transporter
E4U63_RS21015	COG2271	Major facilitator Superfamily
E4U63_RS21020	COG1840	ABC-type Fe3 transport system, periplasmic component
E4U63_RS21030	COG3842	ATPase activity
E4U63_RS21045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4U63_RS21050	COG3122	Protein conserved in bacteria
E4U63_RS21055	COG2814	Major facilitator Superfamily
E4U63_RS21060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4U63_RS21075	COG0596	Alpha beta hydrolase
E4U63_RS21090	COG1414	Transcriptional regulator
E4U63_RS21095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4U63_RS21105	COG1609	Transcriptional regulator
E4U63_RS21110	COG3250	beta-galactosidase activity
E4U63_RS21115	COG2223	nitrite transmembrane transporter activity
E4U63_RS21120	COG0110	maltose O-acetyltransferase activity
E4U63_RS21125	COG2807	transmembrane transport
E4U63_RS21135	COG0288	reversible hydration of carbon dioxide
E4U63_RS21140	COG0583	DNA-binding transcription factor activity
E4U63_RS21145	COG0402	S-adenosylhomocysteine deaminase activity
E4U63_RS21150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4U63_RS21155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4U63_RS21160	COG2079	MmgE PrpD family protein
E4U63_RS21165	COG0372	Belongs to the citrate synthase family
E4U63_RS21170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4U63_RS21175	COG3829	transcription factor binding
E4U63_RS21185	COG1280	lysine exporter protein (LysE YggA)
E4U63_RS21200	COG1064	alcohol dehydrogenase
E4U63_RS21210	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS21215	COG1129	ABC transporter
E4U63_RS21220	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS21230	COG0402	S-adenosylhomocysteine deaminase activity
E4U63_RS21235	COG0549	Belongs to the carbamate kinase family
E4U63_RS21245	COG1304	FMN binding
E4U63_RS21250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4U63_RS21260	COG0666	response to abiotic stimulus
E4U63_RS21275	COG2771	luxR family
E4U63_RS21275	COG2200	EAL domain
E4U63_RS21285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4U63_RS21320	COG2771	luxR family
E4U63_RS21320	COG2200	EAL domain
E4U63_RS21345	COG1556	Lactate utilization protein
E4U63_RS21350	COG1139	Iron-sulfur cluster binding protein
E4U63_RS21355	COG0247	lactate metabolic process
E4U63_RS21360	COG2207	Transcriptional regulator
E4U63_RS21365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U63_RS21375	COG3059	membrane
E4U63_RS21380	COG0656	L-ascorbic acid biosynthetic process
E4U63_RS21385	COG2207	Transcriptional regulator
E4U63_RS21385	COG3708	Transcriptional regulator
E4U63_RS21390	COG1388	LysM domain
E4U63_RS21415	COG0583	DNA-binding transcription factor activity
E4U63_RS21420	COG1073	alpha beta
E4U63_RS21445	COG4372	Transposase
E4U63_RS21450	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS21490	COG3188	usher protein
E4U63_RS21500	COG3121	Chaperone
E4U63_RS21505	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4U63_RS21510	COG3477	response to acidic pH
E4U63_RS21515	COG2080	2 iron, 2 sulfur cluster binding
E4U63_RS21520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4U63_RS21525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4U63_RS21530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4U63_RS21545	COG0583	DNA-binding transcription factor activity
E4U63_RS21555	COG4221	oxidoreductase activity
E4U63_RS21560	COG0583	DNA-binding transcription factor activity
E4U63_RS21645	COG1196	nuclear chromosome segregation
E4U63_RS21650	COG3596	GTP binding
E4U63_RS21655	COG2378	regulation of single-species biofilm formation
E4U63_RS21690	COG2003	Belongs to the UPF0758 family
E4U63_RS21735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4U63_RS21755	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4U63_RS21760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4U63_RS21765	COG1690	Belongs to the RtcB family
E4U63_RS21770	COG0454	-acetyltransferase
E4U63_RS21780	COG2161	toxin-antitoxin pair type II binding
E4U63_RS21785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4U63_RS21805	COG0791	NLP P60 protein
E4U63_RS21810	COG3077	Addiction module antitoxin, RelB DinJ family
E4U63_RS21815	COG3041	Addiction module toxin RelE StbE family
E4U63_RS21820	COG3034	peptidoglycan biosynthetic process
E4U63_RS21825	COG0121	glutamine amidotransferase
E4U63_RS21835	COG1960	acyl-CoA dehydrogenase activity
E4U63_RS21845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4U63_RS21850	COG5433	transposase activity
E4U63_RS21865	COG3209	COG3209 Rhs family protein
E4U63_RS21870	COG5433	transposase activity
E4U63_RS21880	COG3209	COG3209 Rhs family protein
E4U63_RS21890	COG3209	COG3209 Rhs family protein
E4U63_RS21895	COG3501	Rhs element vgr protein
E4U63_RS22010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4U63_RS22020	COG2226	methyltransferase
E4U63_RS22030	COG0741	lytic transglycosylase activity
E4U63_RS22030	COG1388	LysM domain
E4U63_RS22035	COG2226	methyltransferase
E4U63_RS22045	COG0583	DNA-binding transcription factor activity
E4U63_RS22050	COG0656	L-ascorbic acid biosynthetic process
E4U63_RS22085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4U63_RS22090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4U63_RS22095	COG2011	ABC-type metal ion transport system permease component
E4U63_RS22100	COG1464	Belongs to the NlpA lipoprotein family
E4U63_RS22110	COG1720	tRNA m6t6A37 methyltransferase activity
E4U63_RS22120	COG0791	NLP P60 protein
E4U63_RS22125	COG3015	lipoprotein NlpE involved in copper resistance
E4U63_RS22130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4U63_RS22135	COG4681	YaeQ
E4U63_RS22145	COG4568	rho-dependent transcription termination
E4U63_RS22150	COG0037	tRNA processing
E4U63_RS22155	COG0346	lactoylglutathione lyase activity
E4U63_RS22170	COG0587	DNA-directed DNA polymerase activity
E4U63_RS22195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4U63_RS22200	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E4U63_RS22210	COG0750	zinc metalloprotease
E4U63_RS22215	COG0575	Belongs to the CDS family
E4U63_RS22220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4U63_RS22225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4U63_RS22250	COG0024	Methionine aminopeptidase
E4U63_RS22270	COG3835	regulator
E4U63_RS22275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4U63_RS22290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4U63_RS22295	COG2860	membrane
E4U63_RS22320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4U63_RS22325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4U63_RS22330	COG1120	ATPase activity
E4U63_RS22335	COG4774	siderophore transport
E4U63_RS22340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4U63_RS22345	COG1643	Atp-dependent helicase
E4U63_RS22350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4U63_RS22360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4U63_RS22365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4U63_RS22370	COG0617	tRNA 3'-terminal CCA addition
E4U63_RS22375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4U63_RS22385	COG3121	Chaperone
E4U63_RS22390	COG3188	usher protein
E4U63_RS22395	COG3539	Fimbrial protein
E4U63_RS22400	COG3539	Fimbrial protein
E4U63_RS22425	COG5464	transposase or invertase
E4U63_RS22435	COG0726	polysaccharide deacetylase
E4U63_RS22440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS22445	COG0842	Transport permease protein
E4U63_RS22450	COG1131	(ABC) transporter
E4U63_RS22455	COG0288	reversible hydration of carbon dioxide
E4U63_RS22460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4U63_RS22465	COG4993	Dehydrogenase
E4U63_RS22470	COG2132	Multicopper oxidase
E4U63_RS22495	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4U63_RS22500	COG3064	Membrane
E4U63_RS22505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4U63_RS22510	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4U63_RS22515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4U63_RS22520	COG2186	Transcriptional regulator
E4U63_RS22525	COG1113	amino acid transport
E4U63_RS22530	COG3725	Membrane protein required for beta-lactamase induction
E4U63_RS22535	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4U63_RS22540	COG0157	Belongs to the NadC ModD family
E4U63_RS22545	COG4969	Belongs to the N-Me-Phe pilin family
E4U63_RS22550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4U63_RS22555	COG1459	type II secretion system
E4U63_RS22565	COG0237	dephospho-CoA kinase activity
E4U63_RS22580	COG0494	nUDIX hydrolase
E4U63_RS22600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4U63_RS22605	COG0849	cell division
E4U63_RS22610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4U63_RS22615	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4U63_RS22630	COG0772	Belongs to the SEDS family
E4U63_RS22635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4U63_RS22645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4U63_RS22650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4U63_RS22655	COG0768	penicillin binding
E4U63_RS22660	COG3116	cell division
E4U63_RS22675	COG1609	Transcriptional regulator
E4U63_RS22685	COG0440	acetolactate synthase activity
E4U63_RS22690	COG0028	Belongs to the TPP enzyme family
E4U63_RS22695	COG0583	DNA-binding transcription factor activity
E4U63_RS22710	COG0473	3-isopropylmalate dehydrogenase activity
E4U63_RS22730	COG4533	DNA binding
E4U63_RS22740	COG4143	(ABC) transporter
E4U63_RS22745	COG1178	ABC-type Fe3 transport system permease component
E4U63_RS22750	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4U63_RS22755	COG0586	Pfam SNARE associated Golgi protein
E4U63_RS22760	COG4977	sequence-specific DNA binding
E4U63_RS22775	COG0235	Class ii aldolase
E4U63_RS22780	COG0417	DNA replication proofreading
E4U63_RS22790	COG0564	pseudouridine synthase activity
E4U63_RS22800	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U63_RS22805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4U63_RS22810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U63_RS22815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U63_RS22850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4U63_RS22865	COG2271	Major facilitator Superfamily
E4U63_RS22870	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4U63_RS22875	COG0644	oxidoreductase
E4U63_RS22925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4U63_RS22930	COG0505	Belongs to the CarA family
E4U63_RS22950	COG1047	Peptidyl-prolyl cis-trans
E4U63_RS22965	COG0196	riboflavin kinase activity
E4U63_RS22990	COG3121	Chaperone
E4U63_RS22995	COG3188	usher protein
E4U63_RS23005	COG0583	DNA-binding transcription factor activity
E4U63_RS23035	COG4735	regulation of single-species biofilm formation
E4U63_RS23040	COG1584	GPR1 FUN34 yaaH family protein
E4U63_RS23045	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4U63_RS23050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U63_RS23055	COG1115	amino acid carrier protein
E4U63_RS23070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4U63_RS23080	COG0460	homoserine dehydrogenase
E4U63_RS23080	COG0527	aspartate kinase activity
E4U63_RS23090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4U63_RS23100	COG0745	RESPONSE REGULATOR receiver
E4U63_RS23105	COG4452	Inner membrane protein CreD
E4U63_RS23110	COG2205	protein histidine kinase activity
E4U63_RS23115	COG0745	RESPONSE REGULATOR receiver
E4U63_RS23120	COG3045	CreA protein
E4U63_RS23125	COG3708	Transcriptional regulator
E4U63_RS23125	COG2207	Transcriptional regulator
E4U63_RS23135	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E4U63_RS23145	COG0741	lytic transglycosylase activity
E4U63_RS23150	COG0488	(ABC) transporter
E4U63_RS23160	COG1056	cytidyltransferase-related domain
E4U63_RS23160	COG3172	ATPase kinase involved in NAD metabolism
E4U63_RS23165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4U63_RS23170	COG0560	Phosphoserine phosphatase
E4U63_RS23175	COG3726	membrane protein affecting hemolysin expression
E4U63_RS23180	COG3726	membrane protein affecting hemolysin expression
E4U63_RS23180	COG0095	Lipoate-protein ligase
E4U63_RS23215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U63_RS23220	COG0084	hydrolase, TatD family'
E4U63_RS23225	COG4667	esterase of the alpha-beta hydrolase superfamily
E4U63_RS23235	COG2823	Periplasmic or secreted lipoprotein
E4U63_RS23245	COG1011	Hydrolase
E4U63_RS23250	COG0456	acetyltransferase
E4U63_RS23255	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E4U63_RS23275	COG4114	ferric iron reductase
E4U63_RS23280	COG2197	response regulator
E4U63_RS23285	COG2197	response regulator
E4U63_RS23290	COG2966	Psort location CytoplasmicMembrane, score
E4U63_RS23305	COG1484	DNA-dependent DNA replication
E4U63_RS23320	COG1063	alcohol dehydrogenase
E4U63_RS23325	COG1802	Transcriptional regulator
E4U63_RS23330	COG2271	Major facilitator Superfamily
E4U63_RS23335	COG0840	transmembrane signaling receptor activity
E4U63_RS23345	COG1966	Carbon starvation protein
E4U63_RS23350	COG2879	small protein
E4U63_RS23355	COG0523	cobalamin synthesis protein
E4U63_RS23380	COG0732	type I restriction modification DNA specificity domain
E4U63_RS23400	COG5457	Domain of unknown function (DUF1127)
E4U63_RS23405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4U63_RS23415	COG5464	transposase or invertase
E4U63_RS23420	COG2814	Major facilitator Superfamily
E4U63_RS23425	COG2733	membrane
E4U63_RS23430	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4U63_RS23435	COG1924	4 iron, 4 sulfur cluster binding
E4U63_RS23450	COG3204	pilus organization
E4U63_RS23455	COG0477	Major facilitator Superfamily
E4U63_RS23470	COG3366	ferrous iron transmembrane transporter activity
E4U63_RS23475	COG0700	Nucleoside recognition
E4U63_RS23480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4U63_RS23505	COG2186	Transcriptional regulator
E4U63_RS23510	COG0246	Mannitol dehydrogenase
E4U63_RS23520	COG2610	gluconate transmembrane transporter activity
E4U63_RS23525	COG3539	Fimbrial protein
E4U63_RS23530	COG3539	Fimbrial protein
E4U63_RS23535	COG3539	Fimbrial protein
E4U63_RS23540	COG3188	usher protein
E4U63_RS23545	COG3121	Chaperone
E4U63_RS23550	COG3539	Fimbrial protein
E4U63_RS23555	COG3539	Fimbrial protein
E4U63_RS23560	COG4974	Belongs to the 'phage' integrase family
E4U63_RS23565	COG0582	viral genome integration into host DNA
E4U63_RS23570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U63_RS23575	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E4U63_RS23590	COG0210	DNA helicase
E4U63_RS23595	COG1205	dead DEAH box helicase
E4U63_RS23595	COG1111	helicase
E4U63_RS23605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4U63_RS23650	COG0582	viral genome integration into host DNA
E4U63_RS23700	COG1064	alcohol dehydrogenase
E4U63_RS23705	COG0433	COG0433 Predicted ATPase
E4U63_RS23710	COG0795	lipopolysaccharide-transporting ATPase activity
E4U63_RS23715	COG0795	lipopolysaccharide-transporting ATPase activity
E4U63_RS23725	COG2927	DNA polymerase III (CHI subunit)
E4U63_RS23735	COG4269	membrane
E4U63_RS23740	COG0456	acetyltransferase
E4U63_RS23745	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4U63_RS23750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4U63_RS23760	COG2731	YhcH YjgK YiaL family protein
E4U63_RS23765	COG1309	transcriptional regulator
E4U63_RS23770	COG1028	Short-chain dehydrogenase reductase Sdr
E4U63_RS23775	COG0251	oxidation-reduction process
E4U63_RS23795	COG0251	oxidation-reduction process
E4U63_RS23800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4U63_RS23810	COG1609	Transcriptional regulator
E4U63_RS23815	COG1263	PTS System
E4U63_RS23815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4U63_RS23820	COG0366	Alpha amylase catalytic
E4U63_RS23825	COG1328	CTP reductase activity
E4U63_RS23830	COG0602	queuosine metabolic process
E4U63_RS23835	COG3783	Cytochrome b(562)
E4U63_RS23840	COG0312	modulator of DNA gyrase
E4U63_RS23850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4U63_RS23860	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS23865	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS23870	COG1129	ABC transporter
E4U63_RS23875	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS23880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4U63_RS23885	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4U63_RS23890	COG2336	PFAM SpoVT AbrB
E4U63_RS23895	COG2105	PFAM AIG2 family protein
E4U63_RS23900	COG2911	Protein conserved in bacteria
E4U63_RS23905	COG0729	surface antigen
E4U63_RS23915	COG1253	flavin adenine dinucleotide binding
E4U63_RS23925	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4U63_RS23935	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4U63_RS23940	COG0737	Belongs to the 5'-nucleotidase family
E4U63_RS23945	COG1733	regulation of RNA biosynthetic process
E4U63_RS23950	COG0702	epimerase
E4U63_RS23955	COG0697	spore germination
E4U63_RS23965	COG1113	amino acid transport
E4U63_RS23970	COG0545	Peptidyl-prolyl cis-trans isomerase
E4U63_RS23975	COG3061	Opacity-associated protein A
E4U63_RS23985	COG0675	Transposase, IS605 OrfB family
E4U63_RS24010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4U63_RS24045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS24050	COG3414	Phosphotransferase system galactitol-specific IIB component
E4U63_RS24055	COG3037	sugar-specific permease SgaT UlaA
E4U63_RS24070	COG1073	alpha beta
E4U63_RS24075	COG3650	response to hydrogen peroxide
E4U63_RS24085	COG1960	acyl-CoA dehydrogenase activity
E4U63_RS24090	COG0754	glutathionylspermidine amidase activity
E4U63_RS24095	COG5463	Belongs to the UPF0441 family
E4U63_RS24100	COG3766	membrane
E4U63_RS24110	COG1842	Phage shock protein A
E4U63_RS24115	COG3789	protein conserved in bacteria
E4U63_RS24120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4U63_RS24125	COG0557	exoribonuclease II activity
E4U63_RS24140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4U63_RS24145	COG0330	HflC and HflK could
E4U63_RS24150	COG0330	HflC and HflK could
E4U63_RS24155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4U63_RS24175	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4U63_RS24180	COG0802	atpase or kinase
E4U63_RS24185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4U63_RS24185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4U63_RS24215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4U63_RS24230	COG3264	Mechanosensitive ion channel
E4U63_RS24230	COG1511	domain protein
E4U63_RS24235	COG0531	amino acid
E4U63_RS24245	COG1053	succinate dehydrogenase
E4U63_RS24250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4U63_RS24265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4U63_RS24270	COG3040	lipid binding
E4U63_RS24275	COG2076	Multidrug Resistance protein
E4U63_RS24280	COG5510	response to toxic substance
E4U63_RS24285	COG5510	response to toxic substance
E4U63_RS24295	COG1509	lysine 2,3-aminomutase activity
E4U63_RS24320	COG0531	amino acid
E4U63_RS24325	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4U63_RS24330	COG1027	Aspartate ammonia-lyase
E4U63_RS24335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4U63_RS24345	COG4232	protein-disulfide reductase activity
E4U63_RS24350	COG1309	transcriptional regulator
E4U63_RS24360	COG3710	Transcriptional regulator
E4U63_RS24365	COG0531	amino acid
E4U63_RS24370	COG1982	Orn Lys Arg decarboxylase major
E4U63_RS24375	COG3104	oligopeptide transport
E4U63_RS24380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4U63_RS24395	COG2388	GCN5-related N-acetyl-transferase
E4U63_RS24400	COG3592	Divergent 4Fe-4S mono-cluster
E4U63_RS24405	COG3290	protein histidine kinase activity
E4U63_RS24410	COG4565	transcriptional regulatory protein
E4U63_RS24415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4U63_RS24420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS24420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4U63_RS24425	COG3647	Membrane
E4U63_RS24430	COG2211	Major facilitator Superfamily
E4U63_RS24435	COG1486	melibiose metabolic process
E4U63_RS24440	COG2169	Transcriptional regulator
E4U63_RS24445	COG1982	Orn Lys Arg decarboxylase major
E4U63_RS24450	COG2207	Transcriptional regulator
E4U63_RS24455	COG0531	amino acid
E4U63_RS24460	COG2194	sulfuric ester hydrolase activity
E4U63_RS24465	COG0745	RESPONSE REGULATOR receiver
E4U63_RS24470	COG0642	Histidine kinase
E4U63_RS24480	COG0477	Major facilitator Superfamily
E4U63_RS24490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E4U63_RS24495	COG2824	Alkylphosphonate utilization operon protein PhnA
E4U63_RS24500	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4U63_RS24505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4U63_RS24510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4U63_RS24515	COG3639	organic phosphonate transmembrane transporter activity
E4U63_RS24520	COG2188	Transcriptional regulator
E4U63_RS24525	COG3624	Phosphonate C-P lyase system protein PhnG
E4U63_RS24530	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E4U63_RS24535	COG3626	phosphonate metabolism
E4U63_RS24540	COG3627	carbon phosphorus lyase activity
E4U63_RS24545	COG4107	phosphonate C-P lyase system protein PhnK
E4U63_RS24550	COG4778	phosphonate C-P lyase system protein PhnL
E4U63_RS24555	COG3454	Phosphonate metabolism
E4U63_RS24560	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4U63_RS24565	COG0456	acetyltransferase
E4U63_RS24570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4U63_RS24585	COG1129	ABC transporter
E4U63_RS24590	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS24610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS24620	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4U63_RS24630	COG1566	PFAM secretion protein HlyD family protein
E4U63_RS24650	COG1538	Outer membrane efflux protein
E4U63_RS24660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4U63_RS24665	COG1301	dicarboxylic acid transport
E4U63_RS24670	COG4235	cytochrome complex assembly
E4U63_RS24675	COG3088	subunit of a heme lyase
E4U63_RS24680	COG1138	Cytochrome C-type biogenesis protein
E4U63_RS24685	COG3301	Polysulphide reductase, NrfD
E4U63_RS24690	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS24695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4U63_RS24705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4U63_RS24710	COG3162	membrane
E4U63_RS24720	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U63_RS24725	COG0025	NhaP-type Na H and K H
E4U63_RS24730	COG2252	PERMEase
E4U63_RS24735	COG0789	Transcriptional regulator
E4U63_RS24740	COG2207	Transcriptional regulator
E4U63_RS24745	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4U63_RS24755	COG0629	single-stranded DNA binding
E4U63_RS24760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4U63_RS24765	COG2315	Protein conserved in bacteria
E4U63_RS24770	COG0432	Pfam Uncharacterised protein family UPF0047
E4U63_RS24775	COG3700	Belongs to the class B bacterial acid phosphatase family
E4U63_RS24785	COG1448	Aminotransferase
E4U63_RS24790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4U63_RS24795	COG0305	Participates in initiation and elongation during chromosome replication
E4U63_RS24800	COG0604	alcohol dehydrogenase
E4U63_RS24810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U63_RS24850	COG5301	cellulose 1,4-beta-cellobiosidase activity
E4U63_RS24870	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E4U63_RS24910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4U63_RS24920	COG0735	belongs to the Fur family
E4U63_RS24925	COG3237	CsbD-like
E4U63_RS24930	COG0534	Mate efflux family protein
E4U63_RS24940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4U63_RS24960	COG1357	PFAM Pentapeptide repeats (8 copies)
E4U63_RS24975	COG3842	ATPase activity
E4U63_RS24980	COG2182	Extracellular solute-binding protein
E4U63_RS24985	COG1175	transmembrane transport
E4U63_RS24990	COG3833	ABC-type maltose transport systems, permease component
E4U63_RS24995	COG0477	Major facilitator Superfamily
E4U63_RS24995	COG2814	Major facilitator Superfamily
E4U63_RS25015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4U63_RS25040	COG0527	aspartate kinase activity
E4U63_RS25050	COG1187	pseudouridine synthase activity
E4U63_RS25095	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4U63_RS25100	COG0646	methionine synthase
E4U63_RS25100	COG1410	methionine synthase
E4U63_RS25105	COG1414	Transcriptional regulator
E4U63_RS25120	COG2224	Isocitrate lyase
E4U63_RS25125	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4U63_RS25135	COG0456	acetyltransferase
E4U63_RS25165	COG0151	Belongs to the GarS family
E4U63_RS25170	COG2204	response regulator
E4U63_RS25175	COG4191	Histidine kinase
E4U63_RS25180	COG3678	ATP-independent chaperone mediated protein folding
E4U63_RS25195	COG3068	Protein conserved in bacteria
E4U63_RS25230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4U63_RS25235	COG2104	thiamine diphosphate biosynthetic process
E4U63_RS25240	COG2022	thiamine diphosphate biosynthetic process
E4U63_RS25245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4U63_RS25285	COG0250	Participates in transcription elongation, termination and antitermination
E4U63_RS25290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4U63_RS25325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4U63_RS25325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4U63_RS25330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4U63_RS25355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4U63_RS25360	COG4206	TonB-dependent receptor
E4U63_RS25365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4U63_RS25375	COG1309	transcriptional regulator
E4U63_RS25380	COG0477	Major facilitator Superfamily
E4U63_RS25385	COG1473	amidohydrolase
E4U63_RS25395	COG0583	DNA-binding transcription factor activity
E4U63_RS25410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4U63_RS25425	COG2194	sulfuric ester hydrolase activity
E4U63_RS25430	COG2207	Transcriptional regulator
E4U63_RS25435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS25440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4U63_RS25445	COG1882	Formate acetyltransferase
E4U63_RS25450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS25455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS25460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS25460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS25460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4U63_RS25465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4U63_RS25470	COG0371	Dehydrogenase
E4U63_RS25475	COG3738	Protein conserved in bacteria
E4U63_RS25480	COG0697	spore germination
E4U63_RS25490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4U63_RS25495	COG0460	homoserine dehydrogenase
E4U63_RS25495	COG0527	aspartate kinase activity
E4U63_RS25500	COG0626	cystathionine gamma-synthase activity
E4U63_RS25510	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E4U63_RS25525	COG3209	COG3209 Rhs family protein
E4U63_RS25535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4U63_RS25540	COG1609	Transcriptional regulator
E4U63_RS25545	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4U63_RS25560	COG1575	Belongs to the MenA family. Type 1 subfamily
E4U63_RS25585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4U63_RS25595	COG1494	fructose-1,6-bisphosphatase
E4U63_RS25605	COG0589	response to stress
E4U63_RS25610	COG3691	Protein conserved in bacteria
E4U63_RS25615	COG3152	Membrane
E4U63_RS25635	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4U63_RS25650	COG3678	ATP-independent chaperone mediated protein folding
E4U63_RS25655	COG0745	RESPONSE REGULATOR receiver
E4U63_RS25660	COG2205	protein histidine kinase activity
E4U63_RS25665	COG2258	MOSC domain
E4U63_RS25675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4U63_RS25685	COG1917	Cupin 2, conserved barrel domain protein
E4U63_RS25685	COG4977	sequence-specific DNA binding
E4U63_RS25720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS25725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS25725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4U63_RS25730	COG1363	Peptidase, m42
E4U63_RS25735	COG3711	transcriptional antiterminator
E4U63_RS25735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4U63_RS25755	COG0437	4 iron, 4 sulfur cluster binding
E4U63_RS25760	COG2864	formate dehydrogenase
E4U63_RS25770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U63_RS25775	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4U63_RS25790	COG0456	acetyltransferase
E4U63_RS25805	COG1011	Hydrolase
E4U63_RS25810	COG1349	DNA-binding transcription factor activity
E4U63_RS25815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS25820	COG2084	Dehydrogenase
E4U63_RS25825	COG3684	Belongs to the aldolase LacD family
E4U63_RS25830	COG2942	2-epimerase
E4U63_RS25835	COG2017	converts alpha-aldose to the beta-anomer
E4U63_RS25845	COG1501	Belongs to the glycosyl hydrolase 31 family
E4U63_RS25850	COG2211	Major facilitator Superfamily
E4U63_RS25855	COG2211	Major facilitator Superfamily
E4U63_RS25860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4U63_RS25865	COG2271	Major facilitator Superfamily
E4U63_RS25875	COG2188	Transcriptional regulator
E4U63_RS25885	COG0174	glutamine synthetase
E4U63_RS25890	COG3852	Histidine kinase
E4U63_RS25895	COG2204	response regulator
E4U63_RS25905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4U63_RS25910	COG3078	GTPase activator activity
E4U63_RS25920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4U63_RS25920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4U63_RS25925	COG0204	Acyl-transferase
E4U63_RS25930	COG5339	Protein conserved in bacteria
E4U63_RS25935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4U63_RS25940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4U63_RS25945	COG3084	Protein conserved in bacteria
E4U63_RS25950	COG0746	molybdenum cofactor guanylyltransferase activity
E4U63_RS25955	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4U63_RS25985	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4U63_RS25990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4U63_RS25995	COG1739	Uncharacterized protein family UPF0029
E4U63_RS26010	COG0183	Belongs to the thiolase family
E4U63_RS26015	COG0543	2 iron, 2 sulfur cluster binding
E4U63_RS26020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4U63_RS26025	COG0250	Participates in transcription elongation, termination and antitermination
E4U63_RS26030	COG0084	hydrolase, TatD family'
E4U63_RS26035	COG0805	protein transport
E4U63_RS26040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U63_RS26045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4U63_RS26055	COG3165	ubiquinone biosynthetic process from chorismate
E4U63_RS26065	COG1322	Protein conserved in bacteria
E4U63_RS26070	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E4U63_RS26075	COG0412	Dienelactone hydrolase
E4U63_RS26085	COG0583	DNA-binding transcription factor activity
E4U63_RS26090	COG0697	spore germination
E4U63_RS26095	COG0561	phosphatase activity
E4U63_RS26100	COG2267	carboxylic ester hydrolase activity
E4U63_RS26105	COG1280	lysine exporter protein (LysE YggA)
E4U63_RS26110	COG1280	lysine exporter protein (LysE YggA)
E4U63_RS26115	COG0514	ATP-dependent DNA helicase (RecQ)
E4U63_RS26120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E4U63_RS26125	COG2050	protein possibly involved in aromatic compounds catabolism
E4U63_RS26130	COG2962	Rard protein
E4U63_RS26155	COG0598	Magnesium transport protein CorA
E4U63_RS26160	COG3698	Phosphodiester glycosidase
E4U63_RS26165	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4U63_RS26170	COG0210	DNA helicase
E4U63_RS26175	COG1011	Hydrolase
E4U63_RS26185	COG3159	Protein conserved in bacteria
E4U63_RS26195	COG5567	small periplasmic lipoprotein
E4U63_RS26205	COG3072	Adenylate cyclase
E4U63_RS26215	COG1587	Uroporphyrinogen-III synthase
E4U63_RS26220	COG2959	enzyme of heme biosynthesis
E4U63_RS26225	COG3071	HemY protein
E4U63_RS26230	COG3119	arylsulfatase activity
E4U63_RS26235	COG0641	radical SAM
E4U63_RS26265	COG1113	amino acid transport
E4U63_RS26285	COG2244	polysaccharide biosynthetic process
E4U63_RS26290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4U63_RS26295	COG0456	acetyltransferase
E4U63_RS26300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E4U63_RS26305	COG1088	dTDP-glucose 4,6-dehydratase activity
E4U63_RS26310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4U63_RS26315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4U63_RS26320	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E4U63_RS26325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4U63_RS26330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4U63_RS26340	COG3118	belongs to the thioredoxin family
E4U63_RS26355	COG0210	DNA helicase
E4U63_RS26360	COG3692	DNA binding
E4U63_RS26365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4U63_RS26375	COG0583	DNA-binding transcription factor activity
E4U63_RS26380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4U63_RS26390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4U63_RS26395	COG3978	acetolactate synthase activity
E4U63_RS26420	COG3085	chromosome segregation
E4U63_RS26460	COG2186	Transcriptional regulator
E4U63_RS26465	COG0477	Major facilitator Superfamily
E4U63_RS26470	COG1609	Transcriptional regulator
E4U63_RS26475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4U63_RS26480	COG1879	ABC-type sugar transport system periplasmic component
E4U63_RS26485	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4U63_RS26490	COG1129	ABC transporter
E4U63_RS26500	COG3158	transport of potassium into the cell
E4U63_RS26520	COG1522	sequence-specific DNA binding
E4U63_RS26525	COG0716	FMN binding
E4U63_RS26615	COG2274	protein secretion by the type I secretion system
E4U63_RS26780	COG1475	DNA binding
E4U63_RS26865	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4U63_RS26875	COG1525	nuclease
E4U63_RS26950	COG3468	outer membrane autotransporter barrel domain protein
E4U63_RS26960	COG3436	PFAM IS66 Orf2 family protein
E4U63_RS26965	COG4372	Transposase
E4U63_RS26975	COG0726	polysaccharide deacetylase
E4U63_RS26980	COG0297	glycogen (starch) synthase activity
E4U63_RS26985	COG2194	sulfuric ester hydrolase activity
E4U63_RS26990	COG1560	Kdo2-lipid A biosynthetic process