locus-tag	class	description
E3165_RS00015	COG3312	ion transport
E3165_RS00065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3165_RS00090	COG3539	Fimbrial protein
E3165_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3165_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E3165_RS00110	COG0581	inorganic phosphate transmembrane transporter activity
E3165_RS00115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3165_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
E3165_RS00150	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS00160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3165_RS00165	COG2252	PERMEase
E3165_RS00170	COG0431	NADPH-dependent FMN reductase
E3165_RS00175	COG2091	lysine biosynthetic process via aminoadipic acid
E3165_RS00190	COG0814	amino acid
E3165_RS00245	COG0592	DNA-directed DNA polymerase activity
E3165_RS00255	COG0187	DNA topoisomerase II activity
E3165_RS00260	COG3753	Protein conserved in bacteria
E3165_RS00265	COG0561	phosphatase activity
E3165_RS00275	COG0644	oxidoreductase
E3165_RS00280	COG0823	Involved in the tonB-independent uptake of proteins
E3165_RS00285	COG5645	(Lipo)protein
E3165_RS00305	COG2188	Transcriptional regulator
E3165_RS00320	COG2207	Transcriptional regulator
E3165_RS00330	COG3119	arylsulfatase activity
E3165_RS00340	COG2149	membrane
E3165_RS00350	COG0641	radical SAM
E3165_RS00355	COG2814	Major facilitator Superfamily
E3165_RS00370	COG0028	Belongs to the TPP enzyme family
E3165_RS00375	COG0440	acetolactate synthase activity
E3165_RS00395	COG2197	response regulator
E3165_RS00400	COG3851	Histidine kinase
E3165_RS00405	COG2271	Major facilitator Superfamily
E3165_RS00410	COG2271	Major facilitator Superfamily
E3165_RS00440	COG2814	Major facilitator Superfamily
E3165_RS00450	COG1464	Belongs to the NlpA lipoprotein family
E3165_RS00455	COG0697	spore germination
E3165_RS00460	COG2814	Major facilitator Superfamily
E3165_RS00625	COG5492	domain, Protein
E3165_RS00715	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS00725	COG0582	viral genome integration into host DNA
E3165_RS00735	COG2211	Major facilitator Superfamily
E3165_RS00740	COG1501	Belongs to the glycosyl hydrolase 31 family
E3165_RS00745	COG2982	Protein involved in outer membrane biogenesis
E3165_RS00750	COG2233	PERMEase
E3165_RS00755	COG0786	glutamate:sodium symporter activity
E3165_RS00765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3165_RS00770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3165_RS00775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3165_RS00785	COG0194	GDP metabolic process
E3165_RS00795	COG2860	membrane
E3165_RS00800	COG3645	SOS response
E3165_RS00805	COG1561	YicC-like family, N-terminal region
E3165_RS00830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3165_RS00860	COG1519	Transferase
E3165_RS00865	COG0859	PFAM glycosyl transferase family 9
E3165_RS00870	COG0438	transferase activity, transferring glycosyl groups
E3165_RS00875	COG0515	serine threonine protein kinase
E3165_RS00885	COG3642	lipopolysaccharide core region biosynthetic process
E3165_RS00905	COG0859	PFAM glycosyl transferase family 9
E3165_RS00910	COG0859	PFAM glycosyl transferase family 9
E3165_RS00925	COG0156	8-amino-7-oxononanoate synthase activity
E3165_RS00935	COG1216	Glycosyl transferase, family 2
E3165_RS00940	COG2861	carbohydrate metabolic process
E3165_RS00945	COG4942	peptidase
E3165_RS00955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3165_RS00960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3165_RS00975	COG1045	serine acetyltransferase
E3165_RS00980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3165_RS00990	COG2186	Transcriptional regulator
E3165_RS00995	COG1620	l-lactate permease
E3165_RS01000	COG5295	Hep Hag repeat protein
E3165_RS01020	COG3722	fumarate hydratase activity
E3165_RS01030	COG2213	PTS system mannitol-specific
E3165_RS01030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS01040	COG1566	PFAM secretion protein HlyD family protein
E3165_RS01050	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3165_RS01055	COG3209	COG3209 Rhs family protein
E3165_RS01060	COG0625	glutathione transferase activity
E3165_RS01070	COG3276	selenocysteine insertion sequence binding
E3165_RS01075	COG1454	alcohol dehydrogenase
E3165_RS01085	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS01095	COG1566	PFAM secretion protein HlyD family protein
E3165_RS01100	COG0583	DNA-binding transcription factor activity
E3165_RS01105	COG3713	MltA-interacting MipA family protein
E3165_RS01115	COG2211	Major facilitator Superfamily
E3165_RS01125	COG1414	Transcriptional regulator
E3165_RS01130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS01135	COG3977	Valine--pyruvate aminotransferase
E3165_RS01140	COG0366	Alpha amylase catalytic
E3165_RS01145	COG2992	FlgJ-related protein
E3165_RS01150	COG2207	Transcriptional regulator
E3165_RS01150	COG1609	Transcriptional regulator
E3165_RS01155	COG4214	carbohydrate transport
E3165_RS01165	COG4213	ABC transporter substrate-binding protein
E3165_RS01175	COG1070	Carbohydrate kinase
E3165_RS01180	COG4682	membrane
E3165_RS01185	COG4682	membrane
E3165_RS01190	COG3274	enterobacterial common antigen metabolic process
E3165_RS01215	COG1278	Cold shock
E3165_RS01220	COG2944	sequence-specific DNA binding
E3165_RS01235	COG2885	chlorophyll binding
E3165_RS01240	COG0243	molybdopterin cofactor binding
E3165_RS01245	COG0456	acetyltransferase
E3165_RS01250	COG2818	Glycosylase
E3165_RS01255	COG5571	outer membrane autotransporter
E3165_RS01260	COG2223	nitrite transmembrane transporter activity
E3165_RS01265	COG3539	Fimbrial protein
E3165_RS01270	COG3121	Chaperone
E3165_RS01280	COG3539	Fimbrial protein
E3165_RS01285	COG3539	Fimbrial protein
E3165_RS01290	COG2194	sulfuric ester hydrolase activity
E3165_RS01300	COG0747	negative chemotaxis
E3165_RS01305	COG0601	transmembrane transport
E3165_RS01310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3165_RS01315	COG0444	Belongs to the ABC transporter superfamily
E3165_RS01320	COG4608	Belongs to the ABC transporter superfamily
E3165_RS01325	COG0814	amino acid
E3165_RS01335	COG2194	sulfuric ester hydrolase activity
E3165_RS01360	COG1215	transferase activity, transferring glycosyl groups
E3165_RS01365	COG1215	transferase activity, transferring glycosyl groups
E3165_RS01370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E3165_RS01375	COG3118	belongs to the thioredoxin family
E3165_RS01375	COG0457	Tetratricopeptide repeat
E3165_RS01380	COG2200	EAL domain
E3165_RS01380	COG2199	diguanylate cyclase activity
E3165_RS01390	COG0612	Peptidase, M16
E3165_RS01400	COG2200	EAL domain
E3165_RS01405	COG2982	Protein involved in outer membrane biogenesis
E3165_RS01410	COG0477	Major facilitator Superfamily
E3165_RS01415	COG1295	ribonuclease BN
E3165_RS01420	COG0583	DNA-binding transcription factor activity
E3165_RS01425	COG2197	response regulator
E3165_RS01435	COG1858	cytochrome C peroxidase
E3165_RS01440	COG0076	glutamate decarboxylase activity
E3165_RS01445	COG2207	Transcriptional regulator
E3165_RS01450	COG2207	Transcriptional regulator
E3165_RS01455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3165_RS01460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS01470	COG2771	luxR family
E3165_RS01475	COG3247	response to pH
E3165_RS01490	COG1285	pathogenesis
E3165_RS01500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3165_RS01510	COG3721	Heme iron utilization protein
E3165_RS01520	COG4558	Periplasmic binding protein
E3165_RS01530	COG4771	TonB-dependent receptor
E3165_RS01535	COG3720	iron ion transport
E3165_RS01540	COG2197	response regulator
E3165_RS01545	COG3065	identical protein binding
E3165_RS01555	COG1393	Belongs to the ArsC family
E3165_RS01560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3165_RS01565	COG0640	Transcriptional regulator
E3165_RS01575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3165_RS01580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3165_RS01585	COG0339	signal peptide processing
E3165_RS01595	COG3104	oligopeptide transport
E3165_RS01600	COG0589	response to stress
E3165_RS01610	COG0306	phosphate transporter
E3165_RS01615	COG2081	HI0933 family
E3165_RS01635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS01640	COG0842	Transport permease protein
E3165_RS01640	COG1129	ABC transporter
E3165_RS01645	COG0842	Transport permease protein
E3165_RS01660	COG0191	fructose-bisphosphate aldolase activity
E3165_RS01675	COG3775	system Galactitol-specific IIC component
E3165_RS01680	COG3414	Phosphotransferase system galactitol-specific IIB component
E3165_RS01690	COG2188	Transcriptional regulator
E3165_RS01700	COG1124	(ABC) transporter
E3165_RS01705	COG0444	Belongs to the ABC transporter superfamily
E3165_RS01710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3165_RS01715	COG0601	transmembrane transport
E3165_RS01720	COG0747	negative chemotaxis
E3165_RS01725	COG2091	lysine biosynthetic process via aminoadipic acid
E3165_RS01730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3165_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS01745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3165_RS01770	COG1216	Glycosyl transferase, family 2
E3165_RS01790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3165_RS01800	COG0204	Acyl-transferase
E3165_RS01820	COG0628	permease
E3165_RS01835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3165_RS01850	COG3714	YhhN family
E3165_RS01860	COG3776	membrane
E3165_RS01865	COG0742	ribosomal rna small subunit methyltransferase
E3165_RS01870	COG0552	protein localization to endoplasmic reticulum
E3165_RS01875	COG2884	Cell division ATP-binding protein ftsE
E3165_RS01880	COG2177	Part of the ABC transporter FtsEX involved in
E3165_RS01885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3165_RS01890	COG0683	leucine binding
E3165_RS01905	COG0456	acetyltransferase
E3165_RS01910	COG0683	leucine binding
E3165_RS01915	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3165_RS01920	COG4177	L-phenylalanine transmembrane transporter activity
E3165_RS01925	COG0411	ABC transporter
E3165_RS01930	COG0410	ABC transporter
E3165_RS01940	COG1653	transport
E3165_RS01945	COG1175	transmembrane transport
E3165_RS01960	COG0584	glycerophosphoryl diester phosphodiesterase
E3165_RS01970	COG0405	Gamma-glutamyltransferase
E3165_RS01980	COG1247	-acetyltransferase
E3165_RS01985	COG0673	inositol 2-dehydrogenase activity
E3165_RS01990	COG1741	Belongs to the pirin family
E3165_RS01995	COG1609	Transcriptional regulator
E3165_RS02000	COG3265	gluconokinase activity
E3165_RS02005	COG2610	gluconate transmembrane transporter activity
E3165_RS02010	COG0514	ATP-dependent DNA helicase (RecQ)
E3165_RS02030	COG2095	MarC family integral membrane protein
E3165_RS02035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3165_RS02040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3165_RS02060	COG0058	SHG alpha-glucan phosphorylase activity
E3165_RS02065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3165_RS02080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3165_RS02095	COG1349	DNA-binding transcription factor activity
E3165_RS02100	COG4650	regulator
E3165_RS02105	COG1690	Belongs to the RtcB family
E3165_RS02130	COG0058	SHG alpha-glucan phosphorylase activity
E3165_RS02135	COG1640	4-alpha-glucanotransferase
E3165_RS02140	COG2610	gluconate transmembrane transporter activity
E3165_RS02150	COG1040	competence protein
E3165_RS02160	COG5464	transposase or invertase
E3165_RS02170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E3165_RS02175	COG1918	ferrous iron import across plasma membrane
E3165_RS02180	COG2183	response to ionizing radiation
E3165_RS02185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3165_RS02190	COG0745	RESPONSE REGULATOR receiver
E3165_RS02195	COG2205	protein histidine kinase activity
E3165_RS02205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3165_RS02215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3165_RS02220	COG1011	Hydrolase
E3165_RS02230	COG0494	nUDIX hydrolase
E3165_RS02235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E3165_RS02240	COG4972	Pilus assembly protein
E3165_RS02245	COG3166	PFAM Fimbrial assembly family protein
E3165_RS02260	COG4796	Type ii and iii secretion system protein
E3165_RS02275	COG3266	domain, Protein
E3165_RS02280	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E3165_RS02285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3165_RS02290	COG0546	phosphoglycolate phosphatase activity
E3165_RS02295	COG0180	Tryptophanyl-tRNA synthetase
E3165_RS02300	COG2188	Transcriptional regulator
E3165_RS02310	COG1082	Xylose isomerase domain protein TIM barrel
E3165_RS02315	COG2222	sugar isomerase
E3165_RS02320	COG0531	amino acid
E3165_RS02335	COG2116	formate transmembrane transporter activity
E3165_RS02340	COG2146	nitrite reductase [NAD(P)H] activity
E3165_RS02345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3165_RS02355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3165_RS02365	COG2184	nucleotidyltransferase activity
E3165_RS02370	COG0512	Glutamine amidotransferase of anthranilate synthase
E3165_RS02375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3165_RS02380	COG1289	transmembrane transporter activity
E3165_RS02385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3165_RS02390	COG1765	OsmC-like protein
E3165_RS02395	COG3954	Phosphoribulokinase
E3165_RS02405	COG0429	hydrolase of the alpha beta-hydrolase fold
E3165_RS02410	COG0488	(ABC) transporter
E3165_RS02425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3165_RS02430	COG1047	Peptidyl-prolyl cis-trans
E3165_RS02440	COG0545	Peptidyl-prolyl cis-trans isomerase
E3165_RS02445	COG2964	Protein conserved in bacteria
E3165_RS02515	COG0089	rRNA binding
E3165_RS02605	COG0201	protein transport
E3165_RS02645	COG0789	Transcriptional regulator
E3165_RS02650	COG3036	rescue of stalled ribosome
E3165_RS02660	COG0569	domain protein
E3165_RS02680	COG0758	DNA mediated transformation
E3165_RS02690	COG0551	DNA topoisomerase type I activity
E3165_RS02695	COG0009	L-threonylcarbamoyladenylate synthase
E3165_RS02710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3165_RS02750	COG1126	abc transporter atp-binding protein
E3165_RS02755	COG0765	amino acid transport
E3165_RS02760	COG4597	amino acid ABC transporter
E3165_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS02785	COG1309	transcriptional regulator
E3165_RS02795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3165_RS02805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3165_RS02815	COG4145	pantothenate transmembrane transporter activity
E3165_RS02820	COG3924	membrane
E3165_RS02825	COG0439	Biotin carboxylase
E3165_RS02830	COG0511	ligase activity, forming carbon-carbon bonds
E3165_RS02835	COG0604	alcohol dehydrogenase
E3165_RS02840	COG2200	EAL domain
E3165_RS02840	COG2199	diguanylate cyclase activity
E3165_RS02845	COG1077	Cell shape determining protein MreB Mrl
E3165_RS02850	COG1792	Involved in formation and maintenance of cell shape
E3165_RS02855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3165_RS02860	COG0424	maF-like protein
E3165_RS02865	COG1530	ribonuclease E activity
E3165_RS02870	COG3164	Protein of unknown function
E3165_RS02875	COG0312	modulator of DNA gyrase
E3165_RS02880	COG0583	DNA-binding transcription factor activity
E3165_RS02900	COG2732	(Barnase) inhibitor
E3165_RS02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3165_RS02925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3165_RS02930	COG3105	Protein conserved in bacteria
E3165_RS02935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3165_RS02950	COG0625	glutathione transferase activity
E3165_RS02955	COG2969	positive regulation of protein catabolic process
E3165_RS02990	COG2731	YhcH YjgK YiaL family protein
E3165_RS02995	COG4804	nuclease activity
E3165_RS03000	COG0493	'glutamate synthase
E3165_RS03005	COG0070	glutamate synthase
E3165_RS03005	COG0067	glutamate synthase
E3165_RS03005	COG0069	glutamate synthase activity
E3165_RS03010	COG1242	4 iron, 4 sulfur cluster binding
E3165_RS03015	COG0784	Response regulator, receiver
E3165_RS03015	COG2198	Histidine kinase
E3165_RS03015	COG5002	protein histidine kinase activity
E3165_RS03020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3165_RS03030	COG0515	serine threonine protein kinase
E3165_RS03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS03050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3165_RS03055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3165_RS03060	COG1137	ATPase activity
E3165_RS03065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3165_RS03070	COG3117	lipopolysaccharide transmembrane transporter activity
E3165_RS03075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3165_RS03080	COG0517	IMP dehydrogenase activity
E3165_RS03080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3165_RS03085	COG0530	calcium, potassium:sodium antiporter activity
E3165_RS03090	COG1127	ABC transporter
E3165_RS03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3165_RS03100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3165_RS03105	COG2854	intermembrane phospholipid transfer
E3165_RS03110	COG3113	response to antibiotic
E3165_RS03115	COG5007	Belongs to the BolA IbaG family
E3165_RS03130	COG0142	geranyltranstransferase activity
E3165_RS03145	COG0697	spore germination
E3165_RS03155	COG2027	D-alanyl-D-alanine carboxypeptidase
E3165_RS03160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3165_RS03165	COG1534	Rna-binding protein
E3165_RS03175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3165_RS03180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3165_RS03190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3165_RS03200	COG2194	sulfuric ester hydrolase activity
E3165_RS03220	COG0195	Participates in both transcription termination and antitermination
E3165_RS03260	COG0513	Belongs to the DEAD box helicase family
E3165_RS03265	COG0814	amino acid
E3165_RS03270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3165_RS03275	COG0826	peptidase U32
E3165_RS03280	COG0826	peptidase U32
E3165_RS03285	COG3154	lipid carrier protein
E3165_RS03290	COG3153	acetyltransferase
E3165_RS03300	COG3787	Belongs to the UPF0306 family
E3165_RS03305	COG0693	protein deglycase activity
E3165_RS03310	COG0702	epimerase
E3165_RS03315	COG0701	Predicted permease
E3165_RS03320	COG2823	Periplasmic or secreted lipoprotein
E3165_RS03340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3165_RS03345	COG3539	Fimbrial protein
E3165_RS03350	COG3188	usher protein
E3165_RS03355	COG3121	Chaperone
E3165_RS03360	COG3539	Fimbrial protein
E3165_RS03370	COG3716	PTS system mannose fructose sorbose family IID component
E3165_RS03375	COG3715	PTS system
E3165_RS03390	COG2222	sugar isomerase
E3165_RS03395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3165_RS03400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS03405	COG3716	PTS system mannose fructose sorbose family IID component
E3165_RS03415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS03425	COG1349	DNA-binding transcription factor activity
E3165_RS03435	COG2002	toxin-antitoxin pair type II binding
E3165_RS03440	COG2721	sulfolactate sulfo-lyase activity
E3165_RS03445	COG2271	Major facilitator Superfamily
E3165_RS03455	COG2084	Dehydrogenase
E3165_RS03460	COG1929	Belongs to the glycerate kinase type-1 family
E3165_RS03485	COG0583	DNA-binding transcription factor activity
E3165_RS03490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3165_RS03500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3165_RS03505	COG1882	Formate acetyltransferase
E3165_RS03510	COG0251	oxidation-reduction process
E3165_RS03515	COG1760	l-serine dehydratase
E3165_RS03520	COG0814	amino acid
E3165_RS03535	COG1741	Belongs to the pirin family
E3165_RS03540	COG0583	DNA-binding transcription factor activity
E3165_RS03545	COG3152	Membrane
E3165_RS03550	COG3152	Membrane
E3165_RS03555	COG0435	Glutathione S-transferase
E3165_RS03560	COG2259	Doxx family
E3165_RS03570	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E3165_RS03575	COG4575	ribosome binding
E3165_RS03580	COG1422	Protein of unknown function (DUF1090)
E3165_RS03590	COG0586	Pfam SNARE associated Golgi protein
E3165_RS03595	COG2186	Transcriptional regulator
E3165_RS03600	COG2271	Major facilitator Superfamily
E3165_RS03610	COG2721	sulfolactate sulfo-lyase activity
E3165_RS03620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E3165_RS03625	COG0861	Integral membrane protein TerC family
E3165_RS03630	COG0673	inositol 2-dehydrogenase activity
E3165_RS03635	COG2949	membrane
E3165_RS03640	COG1451	nucleotide metabolic process
E3165_RS03650	COG4680	protein conserved in bacteria
E3165_RS03655	COG5499	transcription regulator containing HTH domain
E3165_RS03660	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3165_RS03660	COG1902	pentaerythritol trinitrate reductase activity
E3165_RS03665	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E3165_RS03665	COG3408	Glycogen debranching enzyme
E3165_RS03675	COG0531	amino acid
E3165_RS03680	COG2731	YhcH YjgK YiaL family protein
E3165_RS03685	COG3250	beta-galactosidase activity
E3165_RS03690	COG1609	Transcriptional regulator
E3165_RS03695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3165_RS03705	COG0840	transmembrane signaling receptor activity
E3165_RS03710	COG1695	Transcriptional regulator
E3165_RS03715	COG2375	cellular response to nickel ion
E3165_RS03730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3165_RS03735	COG0358	DNA primase activity
E3165_RS03740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3165_RS03750	COG0471	metal ion transport
E3165_RS03755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS03760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS03765	COG0583	DNA-binding transcription factor activity
E3165_RS03775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3165_RS03790	COG4991	sh3 domain protein
E3165_RS03795	COG3025	triphosphatase activity
E3165_RS03820	COG2268	Band 7 protein
E3165_RS03825	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3165_RS03855	COG3384	dioxygenase
E3165_RS03860	COG0754	glutathionylspermidine amidase activity
E3165_RS03870	COG1538	Outer membrane efflux protein
E3165_RS03875	COG0494	nUDIX hydrolase
E3165_RS03880	COG3151	Protein conserved in bacteria
E3165_RS03885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3165_RS03890	COG3150	esterase
E3165_RS03895	COG0187	DNA topoisomerase II activity
E3165_RS03900	COG4774	siderophore transport
E3165_RS03905	COG1120	ATPase activity
E3165_RS03910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3165_RS03915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3165_RS03925	COG1737	Transcriptional regulator
E3165_RS03930	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3165_RS03935	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3165_RS03940	COG0642	Histidine kinase
E3165_RS03945	COG0745	RESPONSE REGULATOR receiver
E3165_RS03950	COG3111	PFAM Bacterial OB fold (BOF) protein
E3165_RS03955	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3165_RS03960	COG4166	transmembrane transport
E3165_RS03965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3165_RS03970	COG0204	Acyl-transferase
E3165_RS03975	COG2132	Multicopper oxidase
E3165_RS03980	COG1032	radical SAM domain protein
E3165_RS03985	COG4238	major outer membrane lipoprotein
E3165_RS03995	COG0656	L-ascorbic acid biosynthetic process
E3165_RS04000	COG1979	alcohol dehydrogenase
E3165_RS04005	COG2207	Transcriptional regulator
E3165_RS04010	COG0586	Pfam SNARE associated Golgi protein
E3165_RS04015	COG0626	cystathionine gamma-synthase activity
E3165_RS04020	COG0811	peptide transport
E3165_RS04025	COG0848	biopolymer transport protein
E3165_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS04040	COG0667	Aldo Keto reductase
E3165_RS04055	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3165_RS04060	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS04065	COG5557	Pfam Polysulphide reductase, NrfD
E3165_RS04070	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3165_RS04075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3165_RS04080	COG1773	rubredoxin
E3165_RS04085	COG0375	protein maturation
E3165_RS04090	COG0298	carbon dioxide binding
E3165_RS04095	COG0625	glutathione transferase activity
E3165_RS04100	COG0754	glutathionylspermidine amidase activity
E3165_RS04105	COG0306	phosphate transporter
E3165_RS04110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3165_RS04115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3165_RS04120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3165_RS04125	COG2244	polysaccharide biosynthetic process
E3165_RS04135	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E3165_RS04140	COG0795	lipopolysaccharide-transporting ATPase activity
E3165_RS04150	COG0156	8-amino-7-oxononanoate synthase activity
E3165_RS04155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3165_RS04165	COG0318	PFAM AMP-dependent synthetase and ligase
E3165_RS04170	COG0456	acetyltransferase
E3165_RS04175	COG2186	Transcriptional regulator
E3165_RS04180	COG0277	FAD linked oxidase domain protein
E3165_RS04185	COG0277	FAD linked oxidase domain protein
E3165_RS04190	COG0247	lactate metabolic process
E3165_RS04195	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E3165_RS04200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3165_RS04210	COG3064	Membrane
E3165_RS04230	COG3031	protein transport across the cell outer membrane
E3165_RS04240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3165_RS04245	COG1459	type II secretion system
E3165_RS04250	COG2165	general secretion pathway protein
E3165_RS04265	COG4795	General secretion pathway protein
E3165_RS04280	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E3165_RS04315	COG2003	Belongs to the UPF0758 family
E3165_RS04335	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS04410	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS04430	COG3436	PFAM IS66 Orf2 family protein
E3165_RS04500	COG3436	PFAM IS66 Orf2 family protein
E3165_RS04515	COG0582	viral genome integration into host DNA
E3165_RS04525	COG1811	Na channel or pump
E3165_RS04530	COG1982	Orn Lys Arg decarboxylase major
E3165_RS04535	COG2211	Major facilitator Superfamily
E3165_RS04550	COG1194	a g-specific adenine glycosylase
E3165_RS04560	COG3171	Protein conserved in bacteria
E3165_RS04570	COG0252	asparaginase activity
E3165_RS04580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3165_RS04585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3165_RS04595	COG0762	integral membrane protein
E3165_RS04600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3165_RS04620	COG0189	ligase activity
E3165_RS04625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3165_RS04630	COG2356	endonuclease I
E3165_RS04640	COG2814	Major facilitator Superfamily
E3165_RS04645	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS04665	COG1166	arginine decarboxylase activity
E3165_RS04680	COG0501	Belongs to the peptidase M48B family
E3165_RS04685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3165_RS04690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS04695	COG2213	PTS system mannitol-specific
E3165_RS04700	COG1063	alcohol dehydrogenase
E3165_RS04705	COG1494	fructose-1,6-bisphosphatase
E3165_RS04715	COG1072	(Pantothenic acid kinase))
E3165_RS04720	COG1122	ATPase activity
E3165_RS04725	COG1122	ATPase activity
E3165_RS04750	COG0126	phosphoglycerate kinase activity
E3165_RS04755	COG0191	fructose-bisphosphate aldolase activity
E3165_RS04760	COG0668	transmembrane transport
E3165_RS04770	COG2968	Membrane
E3165_RS04780	COG0427	acetyl-CoA hydrolase
E3165_RS04785	COG1024	Enoyl-CoA hydratase
E3165_RS04790	COG1703	isobutyryl-CoA mutase activity
E3165_RS04795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3165_RS04795	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3165_RS04815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3165_RS04830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3165_RS04850	COG0006	proline dipeptidase activity
E3165_RS04855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3165_RS04860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3165_RS04885	COG2723	6-phospho-beta-galactosidase activity
E3165_RS04895	COG1272	protein, Hemolysin III
E3165_RS04905	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3165_RS04915	COG0716	FMN binding
E3165_RS04920	COG4974	Belongs to the 'phage' integrase family
E3165_RS04925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3165_RS04930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3165_RS04940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3165_RS04960	COG2233	PERMEase
E3165_RS04975	COG2252	PERMEase
E3165_RS04980	COG0402	S-adenosylhomocysteine deaminase activity
E3165_RS04985	COG2233	PERMEase
E3165_RS04990	COG2080	2 iron, 2 sulfur cluster binding
E3165_RS04990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3165_RS04995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3165_RS05000	COG0402	S-adenosylhomocysteine deaminase activity
E3165_RS05005	COG0493	'glutamate synthase
E3165_RS05005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS05010	COG2068	MobA-Related Protein
E3165_RS05015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3165_RS05020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3165_RS05020	COG3608	succinylglutamate desuccinylase aspartoacylase
E3165_RS05025	COG0549	Belongs to the carbamate kinase family
E3165_RS05035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3165_RS05040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3165_RS05045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3165_RS05055	COG2080	2 iron, 2 sulfur cluster binding
E3165_RS05060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3165_RS05065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3165_RS05070	COG4942	peptidase
E3165_RS05090	COG2207	Transcriptional regulator
E3165_RS05195	COG2197	response regulator
E3165_RS05200	COG0741	lytic transglycosylase activity
E3165_RS05210	COG0457	Tetratricopeptide repeat
E3165_RS05210	COG3710	Transcriptional regulator
E3165_RS05215	COG0457	Tetratricopeptide repeat
E3165_RS05240	COG3710	Transcriptional regulator
E3165_RS05245	COG2771	luxR family
E3165_RS05250	COG0814	amino acid
E3165_RS05255	COG0183	Belongs to the thiolase family
E3165_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS05275	COG1794	racemase activity, acting on amino acids and derivatives
E3165_RS05280	COG0583	DNA-binding transcription factor activity
E3165_RS05290	COG1609	Transcriptional regulator
E3165_RS05305	COG0667	Aldo Keto reductase
E3165_RS05315	COG0861	Integral membrane protein TerC family
E3165_RS05330	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E3165_RS05350	COG2165	general secretion pathway protein
E3165_RS05355	COG4795	General secretion pathway protein
E3165_RS05365	COG4967	type IV pilus modification protein PilV
E3165_RS05370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3165_RS05375	COG1025	Belongs to the peptidase M16 family
E3165_RS05380	COG1074	ATP-dependent DNA helicase activity
E3165_RS05385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3165_RS05390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3165_RS05390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3165_RS05395	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3165_RS05415	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E3165_RS05420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3165_RS05425	COG2166	iron-sulfur cluster assembly
E3165_RS05430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3165_RS05440	COG0583	DNA-binding transcription factor activity
E3165_RS05445	COG2363	Small membrane protein
E3165_RS05455	COG1349	DNA-binding transcription factor activity
E3165_RS05465	COG1070	Carbohydrate kinase
E3165_RS05475	COG0738	Major facilitator superfamily
E3165_RS05480	COG0235	Class ii aldolase
E3165_RS05485	COG1454	alcohol dehydrogenase
E3165_RS05495	COG1760	l-serine dehydratase
E3165_RS05500	COG0814	amino acid
E3165_RS05505	COG1611	Belongs to the LOG family
E3165_RS05520	COG3098	single-species biofilm formation
E3165_RS05525	COG0564	pseudouridine synthase activity
E3165_RS05530	COG0716	FMN binding
E3165_RS05535	COG2271	Major facilitator Superfamily
E3165_RS05540	COG4948	Mandelate Racemase Muconate Lactonizing
E3165_RS05545	COG4948	Mandelate Racemase Muconate Lactonizing
E3165_RS05550	COG4999	Histidine kinase
E3165_RS05550	COG3850	Histidine kinase
E3165_RS05550	COG2205	protein histidine kinase activity
E3165_RS05550	COG3437	response regulator, receiver
E3165_RS05555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3165_RS05560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3165_RS05565	COG2336	PFAM SpoVT AbrB
E3165_RS05570	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3165_RS05575	COG3956	TIGRFAM MazG family protein
E3165_RS05590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3165_RS05600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3165_RS05610	COG0602	queuosine metabolic process
E3165_RS05615	COG1070	Carbohydrate kinase
E3165_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS05630	COG0277	FAD linked oxidase domain protein
E3165_RS05640	COG2086	electron transfer activity
E3165_RS05650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3165_RS05655	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3165_RS05660	COG0644	oxidoreductase
E3165_RS05665	COG0720	synthase
E3165_RS05670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3165_RS05690	COG1203	CRISPR-associated helicase, Cas3
E3165_RS05705	COG1857	crispr-associated protein
E3165_RS05720	COG1518	maintenance of DNA repeat elements
E3165_RS05725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS05730	COG2234	aminopeptidase activity
E3165_RS05785	COG4942	peptidase
E3165_RS05785	COG1388	LysM domain
E3165_RS05790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3165_RS05795	COG1846	Transcriptional regulator
E3165_RS05800	COG0163	prenyltransferase activity
E3165_RS05805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3165_RS05815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3165_RS05835	COG3604	Transcriptional regulator
E3165_RS05840	COG0309	Hydrogenase expression formation protein (HypE)
E3165_RS05845	COG0409	Hydrogenase expression formation protein
E3165_RS05850	COG0298	carbon dioxide binding
E3165_RS05855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E3165_RS05860	COG0375	protein maturation
E3165_RS05870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS05875	COG0651	ATP synthesis coupled electron transport
E3165_RS05880	COG0650	Formate hydrogenlyase subunit 4
E3165_RS05885	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3165_RS05885	COG3261	NADH dehydrogenase
E3165_RS05890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3165_RS05895	COG3260	NADH ubiquinone oxidoreductase 20
E3165_RS05905	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3165_RS05910	COG2723	6-phospho-beta-galactosidase activity
E3165_RS05915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS05915	COG1263	PTS System
E3165_RS05920	COG1609	Transcriptional regulator
E3165_RS05925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS05930	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E3165_RS05950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3165_RS05950	COG0517	IMP dehydrogenase activity
E3165_RS05955	COG1349	DNA-binding transcription factor activity
E3165_RS05960	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS05975	COG3732	PTS system glucitol sorbitol-specific
E3165_RS05980	COG3730	PTS system glucitol sorbitol-specific
E3165_RS05985	COG2951	lytic endotransglycosylase activity
E3165_RS05990	COG1546	Belongs to the CinA family
E3165_RS06005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3165_RS06010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3165_RS06040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3165_RS06045	COG1238	metal cluster binding
E3165_RS06060	COG2814	Major facilitator Superfamily
E3165_RS06065	COG1566	PFAM secretion protein HlyD family protein
E3165_RS06070	COG1846	Transcriptional regulator
E3165_RS06080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E3165_RS06085	COG2814	Major facilitator Superfamily
E3165_RS06090	COG2113	Glycine betaine
E3165_RS06095	COG4176	ABC-type proline glycine betaine transport system permease component
E3165_RS06100	COG4175	Glycine betaine
E3165_RS06105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3165_RS06110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3165_RS06120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3165_RS06125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3165_RS06135	COG4575	ribosome binding
E3165_RS06150	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3165_RS06155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3165_RS06160	COG0640	Transcriptional regulator
E3165_RS06165	COG0401	homolog of Blt101
E3165_RS06170	COG1652	LysM domain
E3165_RS06175	COG1802	Transcriptional regulator
E3165_RS06180	COG1113	amino acid transport
E3165_RS06185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3165_RS06190	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS06195	COG0579	oxidoreductase
E3165_RS06375	COG0582	viral genome integration into host DNA
E3165_RS06385	COG0582	viral genome integration into host DNA
E3165_RS06475	COG3772	lysozyme
E3165_RS06605	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS06655	COG2867	negative regulation of translational initiation
E3165_RS06665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3165_RS06670	COG0497	DNA recombination
E3165_RS06685	COG4536	flavin adenine dinucleotide binding
E3165_RS06690	COG4137	Cytochrome C assembly protein
E3165_RS06695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3165_RS06720	COG2885	chlorophyll binding
E3165_RS06725	COG2199	diguanylate cyclase activity
E3165_RS06740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3165_RS06745	COG0287	Prephenate dehydrogenase
E3165_RS06745	COG1605	Chorismate mutase
E3165_RS06750	COG1605	Chorismate mutase
E3165_RS06750	COG0077	Prephenate dehydratase
E3165_RS06760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3165_RS06765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3165_RS06770	COG0564	pseudouridine synthase activity
E3165_RS06780	COG0542	response to heat
E3165_RS06805	COG0477	Major facilitator Superfamily
E3165_RS06810	COG5544	Lipoprotein
E3165_RS06815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3165_RS06820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3165_RS06820	COG0045	succinate-CoA ligase (ADP-forming) activity
E3165_RS06820	COG1042	CoA-binding domain protein
E3165_RS06830	COG3118	belongs to the thioredoxin family
E3165_RS06835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3165_RS06850	COG1280	lysine exporter protein (LysE YggA)
E3165_RS06855	COG0583	DNA-binding transcription factor activity
E3165_RS06860	COG0513	Belongs to the DEAD box helicase family
E3165_RS06865	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3165_RS06870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3165_RS06880	COG1595	DNA-templated transcription, initiation
E3165_RS06885	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E3165_RS06890	COG3026	antisigma factor binding
E3165_RS06895	COG3086	response to oxidative stress
E3165_RS06905	COG0681	Belongs to the peptidase S26 family
E3165_RS06925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3165_RS06940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS06945	COG1737	Transcriptional regulator
E3165_RS06950	COG0560	Phosphoserine phosphatase
E3165_RS06955	COG0590	tRNA wobble adenosine to inosine editing
E3165_RS06960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3165_RS06965	COG0047	phosphoribosylformylglycinamidine synthase activity
E3165_RS06965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3165_RS06970	COG2205	protein histidine kinase activity
E3165_RS06975	COG3170	Tfp pilus assembly protein FimV
E3165_RS06980	COG2204	response regulator
E3165_RS06985	COG0347	Belongs to the P(II) protein family
E3165_RS06990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3165_RS06990	COG1017	nitric oxide dioxygenase activity
E3165_RS07000	COG1940	carbohydrate kinase activity
E3165_RS07005	COG0457	Tetratricopeptide repeat
E3165_RS07010	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS07015	COG1129	ABC transporter
E3165_RS07020	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS07025	COG1063	alcohol dehydrogenase
E3165_RS07030	COG2017	converts alpha-aldose to the beta-anomer
E3165_RS07035	COG2259	Doxx family
E3165_RS07060	COG4638	Rieske (2fe-2S)
E3165_RS07065	COG0583	DNA-binding transcription factor activity
E3165_RS07070	COG2814	Major facilitator Superfamily
E3165_RS07075	COG3711	transcriptional antiterminator
E3165_RS07080	COG1073	alpha beta
E3165_RS07085	COG0483	inositol monophosphate 1-phosphatase activity
E3165_RS07105	COG0822	iron-sulfur transferase activity
E3165_RS07125	COG0633	Ferredoxin
E3165_RS07130	COG2975	iron-sulfur cluster assembly
E3165_RS07145	COG2897	thiosulfate sulfurtransferase activity
E3165_RS07150	COG2373	Large extracellular alpha-helical protein
E3165_RS07155	COG4953	penicillin-binding protein 1C
E3165_RS07160	COG0243	molybdopterin cofactor binding
E3165_RS07165	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS07170	COG3302	dmso reductase anchor subunit
E3165_RS07205	COG2976	Protein conserved in bacteria
E3165_RS07220	COG1645	bacterial-type flagellum-dependent swarming motility
E3165_RS07230	COG0517	IMP dehydrogenase activity
E3165_RS07230	COG0516	GMP reductase activity
E3165_RS07245	COG3133	Outer membrane lipoprotein
E3165_RS07260	COG2200	EAL domain
E3165_RS07265	COG0248	Ppx GppA phosphatase
E3165_RS07270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3165_RS07275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3165_RS07290	COG2233	PERMEase
E3165_RS07300	COG1393	Belongs to the ArsC family
E3165_RS07305	COG4783	chaperone-mediated protein folding
E3165_RS07310	COG0628	permease
E3165_RS07315	COG2116	formate transmembrane transporter activity
E3165_RS07320	COG3604	Transcriptional regulator
E3165_RS07330	COG3260	NADH ubiquinone oxidoreductase 20
E3165_RS07335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3165_RS07340	COG3261	NADH dehydrogenase
E3165_RS07340	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3165_RS07345	COG0651	ATP synthesis coupled electron transport
E3165_RS07350	COG4237	Hydrogenase 4 membrane
E3165_RS07355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3165_RS07360	COG0650	Formate hydrogenlyase subunit 4
E3165_RS07370	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS07375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3165_RS07380	COG2716	regulation of RNA biosynthetic process
E3165_RS07390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3165_RS07400	COG2321	neutral zinc metallopeptidase
E3165_RS07410	COG0400	carboxylic ester hydrolase activity
E3165_RS07425	COG1393	Belongs to the ArsC family
E3165_RS07435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3165_RS07440	COG3850	Histidine kinase
E3165_RS07445	COG0493	'glutamate synthase
E3165_RS07445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS07455	COG5342	invasion associated locus B
E3165_RS07460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3165_RS07465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3165_RS07470	COG0281	malic enzyme
E3165_RS07470	COG0280	phosphate acetyltransferase
E3165_RS07475	COG4810	utilization protein
E3165_RS07480	COG4917	ethanolamine utilization protein
E3165_RS07485	COG4766	ethanolamine catabolic process
E3165_RS07490	COG4812	Cobalamin adenosyltransferase
E3165_RS07495	COG0280	phosphate acetyltransferase
E3165_RS07500	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E3165_RS07505	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E3165_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS07515	COG4820	ethanolamine utilization protein (EutJ)
E3165_RS07520	COG1454	alcohol dehydrogenase
E3165_RS07525	COG3192	ethanolamine utilization protein
E3165_RS07530	COG4819	ethanolamine utilization protein
E3165_RS07535	COG4303	Ethanolamine ammonia lyase large subunit
E3165_RS07550	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS07555	COG2963	transposase activity
E3165_RS07565	COG4816	utilization protein
E3165_RS07570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E3165_RS07575	COG2207	Transcriptional regulator
E3165_RS07585	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3165_RS07605	COG2837	iron assimilation
E3165_RS07610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3165_RS07615	COG1263	PTS System
E3165_RS07615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS07635	COG4150	thiosulfate binding
E3165_RS07640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3165_RS07645	COG4208	sulfate ABC transporter
E3165_RS07650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3165_RS07655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3165_RS07670	COG2190	(PTS) system
E3165_RS07675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3165_RS07680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS07685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3165_RS07705	COG3530	Putative quorum-sensing-regulated virulence factor
E3165_RS07710	COG0385	Bile acid
E3165_RS07715	COG0583	DNA-binding transcription factor activity
E3165_RS07755	COG0675	Transposase, IS605 OrfB family
E3165_RS07760	COG3415	Transposase
E3165_RS07765	COG3415	Transposase
E3165_RS07780	COG2199	diguanylate cyclase activity
E3165_RS07780	COG2200	EAL domain
E3165_RS07785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3165_RS07810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS07815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS07820	COG0006	proline dipeptidase activity
E3165_RS07825	COG1363	Peptidase, m42
E3165_RS07830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS07830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS07830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3165_RS07835	COG2207	Transcriptional regulator
E3165_RS07840	COG3279	Response regulator of the LytR AlgR family
E3165_RS07845	COG3275	phosphorelay sensor kinase activity
E3165_RS07850	COG0436	Aminotransferase
E3165_RS07860	COG1560	Kdo2-lipid A biosynthetic process
E3165_RS07885	COG0028	Belongs to the TPP enzyme family
E3165_RS07890	COG0679	Auxin Efflux Carrier
E3165_RS07895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3165_RS07900	COG0784	Response regulator, receiver
E3165_RS07900	COG2198	Histidine kinase
E3165_RS07900	COG2205	protein histidine kinase activity
E3165_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS07905	COG2197	response regulator
E3165_RS07910	COG1566	PFAM secretion protein HlyD family protein
E3165_RS07915	COG0477	Major facilitator Superfamily
E3165_RS07990	COG0582	viral genome integration into host DNA
E3165_RS08000	COG2116	formate transmembrane transporter activity
E3165_RS08005	COG2853	Lipoprotein
E3165_RS08015	COG2067	long-chain fatty acid transport protein
E3165_RS08020	COG3691	Protein conserved in bacteria
E3165_RS08035	COG2062	phosphohistidine phosphatase, SixA
E3165_RS08040	COG3539	Fimbrial protein
E3165_RS08045	COG3188	usher protein
E3165_RS08050	COG3121	Chaperone
E3165_RS08055	COG3539	Fimbrial protein
E3165_RS08060	COG3539	Fimbrial protein
E3165_RS08065	COG3539	Fimbrial protein
E3165_RS08095	COG0730	response to heat
E3165_RS08100	COG3101	peptidyl-lysine hydroxylation
E3165_RS08110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3165_RS08110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3165_RS08115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3165_RS08120	COG2814	Major facilitator Superfamily
E3165_RS08135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3165_RS08145	COG0586	Pfam SNARE associated Golgi protein
E3165_RS08155	COG0285	dihydrofolate synthase activity
E3165_RS08160	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E3165_RS08165	COG1286	toxin biosynthetic process
E3165_RS08170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3165_RS08175	COG0163	prenyltransferase activity
E3165_RS08180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS08185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS08190	COG4215	(ABC) transporter
E3165_RS08195	COG4160	amino acid transport
E3165_RS08200	COG4598	ABC transporter
E3165_RS08205	COG5464	transposase or invertase
E3165_RS08210	COG1090	epimerase
E3165_RS08215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3165_RS08220	COG0625	glutathione transferase activity
E3165_RS08225	COG0625	glutathione transferase activity
E3165_RS08230	COG0622	Phosphoesterase
E3165_RS08235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E3165_RS08240	COG1288	antiporter activity
E3165_RS08245	COG0857	belongs to the CobB CobQ family
E3165_RS08245	COG0280	phosphate acetyltransferase
E3165_RS08250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3165_RS08265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3165_RS08270	COG0471	metal ion transport
E3165_RS08270	COG0490	domain, Protein
E3165_RS08280	COG0436	Aminotransferase
E3165_RS08285	COG0583	DNA-binding transcription factor activity
E3165_RS08305	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E3165_RS08310	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3165_RS08315	COG1034	ATP synthesis coupled electron transport
E3165_RS08330	COG0839	Belongs to the complex I subunit 6 family
E3165_RS08340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3165_RS08345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3165_RS08370	COG5160	protein modification by small protein removal
E3165_RS08380	COG2153	protein acetylation
E3165_RS08385	COG4575	ribosome binding
E3165_RS08390	COG1169	isochorismate synthase
E3165_RS08405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3165_RS08415	COG0318	PFAM AMP-dependent synthetase and ligase
E3165_RS08460	COG0406	alpha-ribazole phosphatase activity
E3165_RS08480	COG1414	Transcriptional regulator
E3165_RS08485	COG4948	Mandelate Racemase Muconate Lactonizing
E3165_RS08490	COG2271	Major facilitator Superfamily
E3165_RS08495	COG3836	Belongs to the HpcH HpaI aldolase family
E3165_RS08500	COG5464	transposase or invertase
E3165_RS08505	COG0247	lactate metabolic process
E3165_RS08515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3165_RS08520	COG2271	Major facilitator Superfamily
E3165_RS08525	COG0584	glycerophosphoryl diester phosphodiesterase
E3165_RS08535	COG0583	DNA-binding transcription factor activity
E3165_RS08540	COG2814	Major facilitator Superfamily
E3165_RS08545	COG3642	lipopolysaccharide core region biosynthetic process
E3165_RS08550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3165_RS08555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3165_RS08560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3165_RS08565	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS08575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3165_RS08580	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E3165_RS08585	COG3234	Protein of unknown function (DUF1175)
E3165_RS08595	COG5445	Predicted secreted protein (DUF2300)
E3165_RS08600	COG5445	Predicted secreted protein (DUF2300)
E3165_RS08605	COG4676	Protein conserved in bacteria
E3165_RS08610	COG0784	Response regulator, receiver
E3165_RS08610	COG2205	protein histidine kinase activity
E3165_RS08615	COG2197	response regulator
E3165_RS08620	COG0642	Histidine kinase
E3165_RS08620	COG2198	Histidine kinase
E3165_RS08625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3165_RS08630	COG1477	protein flavinylation
E3165_RS08635	COG2169	Transcriptional regulator
E3165_RS08635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3165_RS08640	COG3145	DNA-N1-methyladenine dioxygenase activity
E3165_RS08645	COG4615	Cyclic peptide transporter
E3165_RS08665	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS08665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3165_RS08670	COG3062	negative regulation of establishment of protein localization
E3165_RS08680	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS08685	COG0348	domain, Protein
E3165_RS08690	COG3043	anaerobic respiration
E3165_RS08695	COG3005	denitrification pathway
E3165_RS08700	COG4133	protoheme IX ABC transporter activity
E3165_RS08705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3165_RS08710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3165_RS08715	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3165_RS08725	COG1138	Cytochrome C-type biogenesis protein
E3165_RS08730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3165_RS08735	COG4235	cytochrome complex assembly
E3165_RS08735	COG3088	subunit of a heme lyase
E3165_RS08740	COG2197	response regulator
E3165_RS08745	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS08755	COG3083	sulfuric ester hydrolase activity
E3165_RS08775	COG1061	Type III restriction enzyme res subunit
E3165_RS08780	COG1187	pseudouridine synthase activity
E3165_RS08785	COG2814	Major facilitator Superfamily
E3165_RS08795	COG4172	Belongs to the ABC transporter superfamily
E3165_RS08800	COG4239	(ABC) transporter, permease
E3165_RS08805	COG4174	ABC transporter (Permease)
E3165_RS08810	COG4166	transmembrane transport
E3165_RS08815	COG2200	EAL domain
E3165_RS08820	COG0791	NLP P60 protein
E3165_RS08825	COG0671	phosphoesterase, PA-phosphatase related
E3165_RS08830	COG0523	cobalamin synthesis protein
E3165_RS08835	COG0246	Mannitol dehydrogenase
E3165_RS08850	COG2814	Major facilitator Superfamily
E3165_RS08855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS08855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS08860	COG1105	Belongs to the carbohydrate kinase PfkB family
E3165_RS08865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E3165_RS08865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS08865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS08870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS08875	COG2313	pseudouridylate synthase activity
E3165_RS08880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3165_RS08885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3165_RS08895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3165_RS08900	COG1522	sequence-specific DNA binding
E3165_RS08900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS08910	COG2855	membrane
E3165_RS08915	COG0583	DNA-binding transcription factor activity
E3165_RS08920	COG0833	amino acid
E3165_RS08925	COG4771	TonB-dependent receptor
E3165_RS08930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3165_RS08940	COG2311	Membrane
E3165_RS08945	COG1609	Transcriptional regulator
E3165_RS08950	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS08955	COG1129	ABC transporter
E3165_RS08960	COG4211	Belongs to the binding-protein-dependent transport system permease family
E3165_RS08965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3165_RS08965	COG0167	dihydroorotate dehydrogenase activity
E3165_RS08970	COG0493	'glutamate synthase
E3165_RS08980	COG2949	membrane
E3165_RS08990	COG1346	cytolysis
E3165_RS09005	COG2271	Major facilitator Superfamily
E3165_RS09020	COG0625	glutathione transferase activity
E3165_RS09025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3165_RS09030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3165_RS09040	COG1538	Outer membrane efflux protein
E3165_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS09050	COG0586	Pfam SNARE associated Golgi protein
E3165_RS09060	COG1686	Belongs to the peptidase S11 family
E3165_RS09065	COG0277	FAD linked oxidase domain protein
E3165_RS09070	COG1472	Belongs to the glycosyl hydrolase 3 family
E3165_RS09075	COG1732	Glycine betaine
E3165_RS09080	COG1174	glycine betaine transport
E3165_RS09085	COG1125	glycine betaine transport
E3165_RS09090	COG1174	glycine betaine transport
E3165_RS09100	COG0789	Transcriptional regulator
E3165_RS09105	COG3275	phosphorelay sensor kinase activity
E3165_RS09110	COG3279	Response regulator of the LytR AlgR family
E3165_RS09115	COG4807	Protein conserved in bacteria
E3165_RS09120	COG4808	Protein conserved in bacteria
E3165_RS09125	COG4715	Zinc finger, swim domain protein
E3165_RS09130	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E3165_RS09135	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E3165_RS09140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E3165_RS09145	COG0714	Associated with various cellular activities
E3165_RS09155	COG3831	ATPase activity
E3165_RS09175	COG0489	protein tyrosine kinase activity
E3165_RS09185	COG3539	Fimbrial protein
E3165_RS09190	COG3121	Chaperone
E3165_RS09195	COG3188	usher protein
E3165_RS09200	COG3539	Fimbrial protein
E3165_RS09205	COG5455	response to cobalt ion
E3165_RS09240	COG0351	phosphomethylpyrimidine kinase
E3165_RS09245	COG3757	hydrolase, family 25
E3165_RS09250	COG2188	Transcriptional regulator
E3165_RS09255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS09260	COG1397	ADP-ribosylglycohydrolase
E3165_RS09265	COG2211	Major facilitator Superfamily
E3165_RS09270	COG1830	Aldolase
E3165_RS09285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS09290	COG3414	Phosphotransferase system galactitol-specific IIB component
E3165_RS09295	COG3775	system Galactitol-specific IIC component
E3165_RS09300	COG1063	alcohol dehydrogenase
E3165_RS09325	COG3422	double-strand break repair
E3165_RS09330	COG0745	RESPONSE REGULATOR receiver
E3165_RS09335	COG2205	protein histidine kinase activity
E3165_RS09350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3165_RS09375	COG4245	von Willebrand factor, type A
E3165_RS09380	COG0631	protein serine/threonine phosphatase activity
E3165_RS09385	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E3165_RS09390	COG0443	Heat shock 70 kDa protein
E3165_RS09395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E3165_RS09400	COG3447	MASE1 domain protein
E3165_RS09400	COG5001	Diguanylate cyclase
E3165_RS09400	COG5002	protein histidine kinase activity
E3165_RS09405	COG0572	uridine kinase
E3165_RS09415	COG2982	Protein involved in outer membrane biogenesis
E3165_RS09430	COG1253	flavin adenine dinucleotide binding
E3165_RS09440	COG1596	polysaccharide export
E3165_RS09445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3165_RS09450	COG0489	protein tyrosine kinase activity
E3165_RS09450	COG3206	protein involved in exopolysaccharide biosynthesis
E3165_RS09455	COG0463	Glycosyl transferase, family 2
E3165_RS09460	COG1045	serine acetyltransferase
E3165_RS09465	COG0438	transferase activity, transferring glycosyl groups
E3165_RS09475	COG1216	Glycosyl transferase, family 2
E3165_RS09480	COG0110	maltose O-acetyltransferase activity
E3165_RS09485	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E3165_RS09490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3165_RS09495	COG1051	belongs to the nudix hydrolase family
E3165_RS09500	COG0297	glycogen (starch) synthase activity
E3165_RS09505	COG0662	Cupin 2, conserved barrel domain protein
E3165_RS09505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3165_RS09510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3165_RS09515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3165_RS09520	COG2244	polysaccharide biosynthetic process
E3165_RS09525	COG2327	Polysaccharide pyruvyl transferase
E3165_RS09530	COG0438	transferase activity, transferring glycosyl groups
E3165_RS09540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3165_RS09545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3165_RS09570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3165_RS09580	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E3165_RS09585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3165_RS09590	COG1051	belongs to the nudix hydrolase family
E3165_RS09595	COG0662	Cupin 2, conserved barrel domain protein
E3165_RS09595	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3165_RS09600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3165_RS09610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E3165_RS09615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3165_RS09640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3165_RS09645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3165_RS09645	COG0131	Imidazoleglycerol-phosphate dehydratase
E3165_RS09655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3165_RS09670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3165_RS09675	COG0583	DNA-binding transcription factor activity
E3165_RS09685	COG0531	amino acid
E3165_RS09690	COG2391	methyltransferase activity
E3165_RS09695	COG0425	Belongs to the sulfur carrier protein TusA family
E3165_RS09700	COG2925	Exonuclease
E3165_RS09705	COG1686	Belongs to the peptidase S11 family
E3165_RS09715	COG1289	transmembrane transporter activity
E3165_RS09725	COG4917	ethanolamine utilization protein
E3165_RS09760	COG2003	Belongs to the UPF0758 family
E3165_RS09855	COG1475	DNA binding
E3165_RS09860	COG4771	TonB-dependent receptor
E3165_RS09865	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E3165_RS09880	COG1376	ErfK ybiS ycfS ynhG family protein
E3165_RS09890	COG0583	DNA-binding transcription factor activity
E3165_RS09895	COG0583	DNA-binding transcription factor activity
E3165_RS09905	COG0534	Mate efflux family protein
E3165_RS09915	COG0217	transcriptional regulatory protein
E3165_RS09920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3165_RS09925	COG0477	Major facilitator Superfamily
E3165_RS09935	COG2373	Large extracellular alpha-helical protein
E3165_RS09935	COG1388	LysM domain
E3165_RS09935	COG4932	domain protein
E3165_RS09965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS10010	COG1846	Transcriptional regulator
E3165_RS10055	COG1403	HNH endonuclease
E3165_RS10060	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS10065	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS10115	COG3772	lysozyme
E3165_RS10145	COG4220	transposase activity
E3165_RS10220	COG2032	superoxide dismutase activity
E3165_RS10240	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS10260	COG3038	cytochrome b561
E3165_RS10265	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3165_RS10280	COG2351	hydroxyisourate hydrolase activity
E3165_RS10285	COG0745	RESPONSE REGULATOR receiver
E3165_RS10290	COG2205	protein histidine kinase activity
E3165_RS10300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3165_RS10310	COG1418	mRNA catabolic process
E3165_RS10315	COG0270	DNA (cytosine-5-)-methyltransferase activity
E3165_RS10320	COG3727	T/G mismatch-specific endonuclease activity
E3165_RS10325	COG0697	spore germination
E3165_RS10330	COG2354	Protein conserved in bacteria
E3165_RS10335	COG5475	Uncharacterized small protein (DUF2158)
E3165_RS10340	COG3706	GGDEF domain
E3165_RS10360	COG2197	response regulator
E3165_RS10365	COG1684	flagellar biosynthetic protein fliR
E3165_RS10370	COG1987	bacterial-type flagellum assembly
E3165_RS10375	COG1338	Plays a role in the flagellum-specific transport system
E3165_RS10380	COG3190	flagellar
E3165_RS10385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3165_RS10390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3165_RS10395	COG1580	Controls the rotational direction of flagella during chemotaxis
E3165_RS10400	COG3144	bacterial-type flagellum assembly
E3165_RS10405	COG2882	bacterial-type flagellum organization
E3165_RS10410	COG1157	protein secretion by the type III secretion system
E3165_RS10415	COG1317	bacterial-type flagellum organization
E3165_RS10420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3165_RS10425	COG1766	The M ring may be actively involved in energy transduction
E3165_RS10440	COG0454	-acetyltransferase
E3165_RS10450	COG0454	-acetyltransferase
E3165_RS10455	COG2135	peptidase activity
E3165_RS10460	COG0425	Belongs to the sulfur carrier protein TusA family
E3165_RS10465	COG2391	methyltransferase activity
E3165_RS10475	COG0366	Alpha amylase catalytic
E3165_RS10485	COG1516	flagellar protein fliS
E3165_RS10490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E3165_RS10500	COG1191	sigma factor activity
E3165_RS10530	COG2197	response regulator
E3165_RS10545	COG2197	response regulator
E3165_RS10635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3165_RS10645	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS10645	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS10725	COG4695	Portal protein
E3165_RS10830	COG4974	Belongs to the 'phage' integrase family
E3165_RS10835	COG3318	Belongs to the UPF0149 family
E3165_RS10835	COG3012	SEC-C Motif Domain Protein
E3165_RS10840	COG0814	amino acid
E3165_RS10850	COG1528	Iron-storage protein
E3165_RS10870	COG1528	Iron-storage protein
E3165_RS10875	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS10880	COG1129	ABC transporter
E3165_RS10885	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS10890	COG1877	trehalose-phosphatase activity
E3165_RS10900	COG0589	response to stress
E3165_RS10915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3165_RS10920	COG1360	Flagellar Motor Protein
E3165_RS10925	COG2198	Histidine kinase
E3165_RS10925	COG0643	Histidine kinase
E3165_RS10930	COG0835	chemotaxis
E3165_RS10935	COG0840	transmembrane signaling receptor activity
E3165_RS10940	COG0840	transmembrane signaling receptor activity
E3165_RS10945	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3165_RS10950	COG2201	protein-glutamate methylesterase activity
E3165_RS10955	COG0745	RESPONSE REGULATOR receiver
E3165_RS10965	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3165_RS10970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3165_RS10980	COG3755	Protein conserved in bacteria
E3165_RS10990	COG3102	Protein conserved in bacteria
E3165_RS11000	COG3005	denitrification pathway
E3165_RS11005	COG0243	molybdopterin cofactor binding
E3165_RS11020	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E3165_RS11025	COG1801	Protein of unknown function DUF72
E3165_RS11030	COG1335	isochorismatase
E3165_RS11040	COG0494	nUDIX hydrolase
E3165_RS11045	COG0217	transcriptional regulatory protein
E3165_RS11075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3165_RS11085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E3165_RS11090	COG0739	heme binding
E3165_RS11095	COG1560	Kdo2-lipid A biosynthetic process
E3165_RS11100	COG0469	pyruvate kinase activity
E3165_RS11105	COG1737	Transcriptional regulator
E3165_RS11110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3165_RS11115	COG0129	dihydroxy-acid dehydratase activity
E3165_RS11120	COG0800	Aldolase
E3165_RS11125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E3165_RS11130	COG3141	response to X-ray
E3165_RS11140	COG2979	Protein of unknown function (DUF533)
E3165_RS11145	COG1770	oligopeptidase
E3165_RS11150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS11155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3165_RS11165	COG2372	response to copper ion
E3165_RS11170	COG1276	copper resistance
E3165_RS11200	COG3008	intermembrane lipid transfer
E3165_RS11205	COG2995	paraquat-inducible protein a
E3165_RS11210	COG1956	GAF domain-containing protein
E3165_RS11220	COG0793	Belongs to the peptidase S41A family
E3165_RS11230	COG2814	Major facilitator Superfamily
E3165_RS11235	COG1414	Transcriptional regulator
E3165_RS11265	COG2226	methyltransferase
E3165_RS11280	COG3716	PTS system mannose fructose sorbose family IID component
E3165_RS11285	COG3715	PTS system
E3165_RS11290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS11290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS11295	COG1253	flavin adenine dinucleotide binding
E3165_RS11300	COG2200	EAL domain
E3165_RS11305	COG1760	l-serine dehydratase
E3165_RS11315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3165_RS11330	COG0251	oxidation-reduction process
E3165_RS11335	COG1199	ATP-dependent helicase activity
E3165_RS11340	COG1214	PFAM Peptidase M22, glycoprotease
E3165_RS11345	COG3065	identical protein binding
E3165_RS11350	COG0318	PFAM AMP-dependent synthetase and ligase
E3165_RS11355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3165_RS11360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3165_RS11365	COG4638	Rieske (2fe-2S)
E3165_RS11370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3165_RS11375	COG0473	3-isopropylmalate dehydrogenase activity
E3165_RS11380	COG0583	DNA-binding transcription factor activity
E3165_RS11385	COG1280	lysine exporter protein (LysE YggA)
E3165_RS11390	COG3615	Tellurite resistance protein tehB
E3165_RS11400	COG2261	transglycosylase associated protein
E3165_RS11415	COG2203	Gaf domain
E3165_RS11415	COG2199	diguanylate cyclase activity
E3165_RS11420	COG3042	response to heat
E3165_RS11425	COG3189	MarR family transcriptional regulator
E3165_RS11430	COG2807	transmembrane transport
E3165_RS11435	COG2207	Transcriptional regulator
E3165_RS11450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3165_RS11455	COG2199	diguanylate cyclase activity
E3165_RS11460	COG2199	diguanylate cyclase activity
E3165_RS11470	COG2766	serine protein kinase
E3165_RS11475	COG3713	MltA-interacting MipA family protein
E3165_RS11480	COG0656	L-ascorbic acid biosynthetic process
E3165_RS11485	COG0676	glucose-6-phosphate 1-epimerase activity
E3165_RS11490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3165_RS11500	COG3139	Protein of unknown function (DUF1315)
E3165_RS11505	COG1063	alcohol dehydrogenase
E3165_RS11510	COG2271	Major facilitator Superfamily
E3165_RS11515	COG1063	alcohol dehydrogenase
E3165_RS11520	COG0191	fructose-bisphosphate aldolase activity
E3165_RS11525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS11530	COG0667	Aldo Keto reductase
E3165_RS11535	COG1349	DNA-binding transcription factor activity
E3165_RS11540	COG2814	Major facilitator Superfamily
E3165_RS11545	COG1335	isochorismatase
E3165_RS11550	COG0252	asparaginase activity
E3165_RS11560	COG0616	signal peptide processing
E3165_RS11565	COG0778	Nitroreductase
E3165_RS11570	COG0709	Synthesizes selenophosphate from selenide and ATP
E3165_RS11575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3165_RS11585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3165_RS11595	COG0494	nUDIX hydrolase
E3165_RS11600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3165_RS11605	COG2897	thiosulfate sulfurtransferase activity
E3165_RS11610	COG4136	ATPase activity
E3165_RS11615	COG4135	transport system, permease component
E3165_RS11620	COG4134	Bacterial extracellular solute-binding protein
E3165_RS11625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3165_RS11630	COG0398	Pfam SNARE associated Golgi protein
E3165_RS11640	COG0398	Pfam SNARE associated Golgi protein
E3165_RS11645	COG0708	Exodeoxyribonuclease III
E3165_RS11675	COG3678	ATP-independent chaperone mediated protein folding
E3165_RS11685	COG0322	excinuclease ABC activity
E3165_RS11695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3165_RS11700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3165_RS11705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3165_RS11710	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3165_RS11715	COG1917	Cupin 2, conserved barrel domain protein
E3165_RS11715	COG2169	Transcriptional regulator
E3165_RS11720	COG1486	melibiose metabolic process
E3165_RS11730	COG0753	catalase activity
E3165_RS11750	COG1988	membrane-bound metal-dependent
E3165_RS11755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3165_RS11765	COG3001	Fructosamine kinase
E3165_RS11775	COG1105	Belongs to the carbohydrate kinase PfkB family
E3165_RS11780	COG3137	Salt-induced outer membrane protein
E3165_RS11825	COG0072	phenylalanine-tRNA ligase activity
E3165_RS11825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3165_RS11840	COG0386	Belongs to the glutathione peroxidase family
E3165_RS11850	COG0791	NLP P60 protein
E3165_RS11855	COG2200	EAL domain
E3165_RS11865	COG4256	Hemin uptake protein
E3165_RS11870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3165_RS11880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3165_RS11880	COG0574	Belongs to the PEP-utilizing enzyme family
E3165_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
E3165_RS11890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3165_RS11895	COG0644	oxidoreductase
E3165_RS11900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3165_RS11905	COG2086	electron transfer activity
E3165_RS11910	COG2207	Transcriptional regulator
E3165_RS11910	COG1917	Cupin 2, conserved barrel domain protein
E3165_RS11915	COG1960	acyl-CoA dehydrogenase activity
E3165_RS11920	COG4670	ketone body catabolic process
E3165_RS11935	COG2271	Major facilitator Superfamily
E3165_RS11940	COG0738	Major facilitator superfamily
E3165_RS11955	COG0628	permease
E3165_RS11960	COG0277	FAD linked oxidase domain protein
E3165_RS11960	COG0247	lactate metabolic process
E3165_RS11965	COG2050	protein possibly involved in aromatic compounds catabolism
E3165_RS11975	COG0316	Belongs to the HesB IscA family
E3165_RS11980	COG0719	Fe-S assembly protein
E3165_RS11985	COG0396	ATPase activity
E3165_RS11990	COG0719	Fe-S assembly protein
E3165_RS12005	COG1376	ErfK ybiS ycfS ynhG family protein
E3165_RS12010	COG4238	major outer membrane lipoprotein
E3165_RS12015	COG0469	pyruvate kinase activity
E3165_RS12025	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS12030	COG2414	aldehyde ferredoxin oxidoreductase
E3165_RS12040	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS12045	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E3165_RS12055	COG4529	Protein conserved in bacteria
E3165_RS12075	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS12085	COG0307	riboflavin synthase, alpha
E3165_RS12090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3165_RS12095	COG2814	Major facilitator Superfamily
E3165_RS12100	COG0583	DNA-binding transcription factor activity
E3165_RS12115	COG2814	Major facilitator Superfamily
E3165_RS12120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3165_RS12125	COG0791	NLP P60 protein
E3165_RS12130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3165_RS12135	COG1201	RNA secondary structure unwinding
E3165_RS12145	COG0346	lactoylglutathione lyase activity
E3165_RS12150	COG1902	pentaerythritol trinitrate reductase activity
E3165_RS12155	COG1309	transcriptional regulator
E3165_RS12160	COG3313	Fe-S protein
E3165_RS12165	COG4989	oxidoreductase activity
E3165_RS12170	COG2032	superoxide dismutase activity
E3165_RS12175	COG1289	transmembrane transporter activity
E3165_RS12180	COG1566	PFAM secretion protein HlyD family protein
E3165_RS12195	COG3133	Outer membrane lipoprotein
E3165_RS12205	COG3895	Periplasmic Protein
E3165_RS12220	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3165_RS12225	COG0625	glutathione transferase activity
E3165_RS12230	COG3104	oligopeptide transport
E3165_RS12235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3165_RS12245	COG4659	FMN binding
E3165_RS12285	COG0673	inositol 2-dehydrogenase activity
E3165_RS12295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3165_RS12300	COG1263	PTS System
E3165_RS12300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS12305	COG1609	Transcriptional regulator
E3165_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS12315	COG1309	transcriptional regulator
E3165_RS12320	COG3250	beta-galactosidase activity
E3165_RS12335	COG5339	Protein conserved in bacteria
E3165_RS12340	COG1482	cell wall glycoprotein biosynthetic process
E3165_RS12345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS12345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS12350	COG0114	fumarate hydratase activity
E3165_RS12360	COG2205	protein histidine kinase activity
E3165_RS12365	COG0745	RESPONSE REGULATOR receiver
E3165_RS12370	COG3136	membrane protein required for alginate biosynthesis
E3165_RS12380	COG0531	amino acid
E3165_RS12390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3165_RS12395	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3165_RS12400	COG0628	permease
E3165_RS12415	COG3591	Belongs to the peptidase S1B family
E3165_RS12430	COG2814	Major facilitator Superfamily
E3165_RS12435	COG0583	DNA-binding transcription factor activity
E3165_RS12440	COG1940	carbohydrate kinase activity
E3165_RS12445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3165_RS12455	COG3381	protein complex oligomerization
E3165_RS12460	COG3302	dmso reductase anchor subunit
E3165_RS12465	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS12470	COG0243	molybdopterin cofactor binding
E3165_RS12475	COG0243	molybdopterin cofactor binding
E3165_RS12490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3165_RS12565	COG1846	Transcriptional regulator
E3165_RS12570	COG1484	DNA-dependent DNA replication
E3165_RS12575	COG1846	Transcriptional regulator
E3165_RS12610	COG1403	HNH endonuclease
E3165_RS12615	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS12665	COG3772	lysozyme
E3165_RS12795	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS12880	COG0582	viral genome integration into host DNA
E3165_RS12890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS12930	COG1396	sequence-specific DNA binding
E3165_RS12955	COG1846	Transcriptional regulator
E3165_RS12985	COG1403	HNH endonuclease
E3165_RS12990	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS13035	COG3772	lysozyme
E3165_RS13165	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS13185	COG3328	transposase activity
E3165_RS13195	COG0582	viral genome integration into host DNA
E3165_RS13205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS13260	COG1846	Transcriptional regulator
E3165_RS13295	COG3111	PFAM Bacterial OB fold (BOF) protein
E3165_RS13305	COG1403	HNH endonuclease
E3165_RS13310	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS13325	COG2207	Transcriptional regulator
E3165_RS13365	COG3772	lysozyme
E3165_RS13395	COG4220	transposase activity
E3165_RS13415	COG1030	water channel activity
E3165_RS13500	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS13525	COG0477	Major facilitator Superfamily
E3165_RS13530	COG0246	Mannitol dehydrogenase
E3165_RS13540	COG1802	Transcriptional regulator
E3165_RS13545	COG4221	oxidoreductase activity
E3165_RS13550	COG0339	signal peptide processing
E3165_RS13555	COG1546	Belongs to the CinA family
E3165_RS13560	COG3111	PFAM Bacterial OB fold (BOF) protein
E3165_RS13565	COG3706	GGDEF domain
E3165_RS13585	COG2814	Major facilitator Superfamily
E3165_RS13590	COG0697	spore germination
E3165_RS13600	COG4977	sequence-specific DNA binding
E3165_RS13605	COG1846	Transcriptional regulator
E3165_RS13615	COG2814	Major facilitator Superfamily
E3165_RS13625	COG0583	DNA-binding transcription factor activity
E3165_RS13630	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS13635	COG2066	Belongs to the glutaminase family
E3165_RS13645	COG2199	diguanylate cyclase activity
E3165_RS13680	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS13685	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS13690	COG1129	ABC transporter
E3165_RS13700	COG1070	Carbohydrate kinase
E3165_RS13705	COG3210	domain, Protein
E3165_RS13705	COG2911	Protein conserved in bacteria
E3165_RS13715	COG1396	sequence-specific DNA binding
E3165_RS13720	COG3550	peptidyl-serine autophosphorylation
E3165_RS13725	COG3539	Fimbrial protein
E3165_RS13735	COG3188	usher protein
E3165_RS13740	COG3539	Fimbrial protein
E3165_RS13745	COG3539	Fimbrial protein
E3165_RS13750	COG3539	Fimbrial protein
E3165_RS13755	COG0243	molybdopterin cofactor binding
E3165_RS13765	COG2207	Transcriptional regulator
E3165_RS13770	COG3119	arylsulfatase activity
E3165_RS13775	COG0641	radical SAM
E3165_RS13785	COG4178	(ABC) transporter
E3165_RS13790	COG4771	TonB-dependent receptor
E3165_RS13795	COG0612	Peptidase, M16
E3165_RS13800	COG0076	glutamate decarboxylase activity
E3165_RS13805	COG0531	amino acid
E3165_RS13815	COG3706	GGDEF domain
E3165_RS13825	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E3165_RS13830	COG0747	negative chemotaxis
E3165_RS13835	COG0601	transmembrane transport
E3165_RS13840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3165_RS13845	COG0444	Belongs to the ABC transporter superfamily
E3165_RS13850	COG4608	Belongs to the ABC transporter superfamily
E3165_RS13855	COG1764	response to oxidative stress
E3165_RS13875	COG1064	alcohol dehydrogenase
E3165_RS13880	COG3093	addiction module antidote protein HigA
E3165_RS13885	COG2864	formate dehydrogenase
E3165_RS13890	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS13900	COG0697	spore germination
E3165_RS13915	COG4886	Leucine-rich repeat (LRR) protein
E3165_RS13920	COG4886	Leucine-rich repeat (LRR) protein
E3165_RS13925	COG2223	nitrite transmembrane transporter activity
E3165_RS13930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3165_RS13935	COG1140	nitrate reductase beta subunit
E3165_RS13940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3165_RS13945	COG2181	nitrate reductase activity
E3165_RS13950	COG0384	phenazine biosynthesis protein PhzF
E3165_RS13955	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E3165_RS13960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3165_RS13990	COG3209	COG3209 Rhs family protein
E3165_RS13995	COG3501	Rhs element vgr protein
E3165_RS14005	COG0625	glutathione transferase activity
E3165_RS14010	COG1113	amino acid transport
E3165_RS14015	COG3391	amine dehydrogenase activity
E3165_RS14020	COG4772	TonB-dependent receptor
E3165_RS14025	COG1802	Transcriptional regulator
E3165_RS14030	COG2130	NADP-dependent
E3165_RS14035	COG1247	-acetyltransferase
E3165_RS14040	COG3238	Protein conserved in bacteria
E3165_RS14065	COG1177	transmembrane transport
E3165_RS14070	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3165_RS14075	COG3842	ATPase activity
E3165_RS14085	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS14095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3165_RS14100	COG1598	PFAM Uncharacterised protein family UPF0150
E3165_RS14105	COG1724	mRNA binding
E3165_RS14115	COG0826	peptidase U32
E3165_RS14120	COG1396	sequence-specific DNA binding
E3165_RS14125	COG3135	benzoate transporter
E3165_RS14135	COG0500	methyltransferase
E3165_RS14140	COG1275	C4-dicarboxylate transporter malic acid transport protein
E3165_RS14145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3165_RS14150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3165_RS14155	COG2841	Protein conserved in bacteria
E3165_RS14165	COG5383	Protein conserved in bacteria
E3165_RS14170	COG0583	DNA-binding transcription factor activity
E3165_RS14175	COG0840	transmembrane signaling receptor activity
E3165_RS14190	COG3038	cytochrome b561
E3165_RS14195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3165_RS14200	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS14205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3165_RS14230	COG1643	Atp-dependent helicase
E3165_RS14235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3165_RS14240	COG0671	phosphoesterase, PA-phosphatase related
E3165_RS14240	COG2453	phosphatase
E3165_RS14245	COG2267	carboxylic ester hydrolase activity
E3165_RS14250	COG4589	Belongs to the CDS family
E3165_RS14255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3165_RS14265	COG0667	Aldo Keto reductase
E3165_RS14280	COG3784	Protein of unknown function (DUF1318)
E3165_RS14290	COG2911	Protein conserved in bacteria
E3165_RS14295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3165_RS14300	COG3187	Heat shock protein
E3165_RS14305	COG3042	response to heat
E3165_RS14310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3165_RS14310	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3165_RS14310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3165_RS14310	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3165_RS14315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3165_RS14320	COG0589	response to stress
E3165_RS14330	COG0513	Belongs to the DEAD box helicase family
E3165_RS14350	COG2840	Smr protein MutS2
E3165_RS14355	COG0583	DNA-binding transcription factor activity
E3165_RS14360	COG1473	amidohydrolase
E3165_RS14365	COG1473	amidohydrolase
E3165_RS14370	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3165_RS14375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3165_RS14380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3165_RS14385	COG0589	response to stress
E3165_RS14390	COG3182	Iron-regulated membrane protein
E3165_RS14395	COG0668	transmembrane transport
E3165_RS14400	COG4166	transmembrane transport
E3165_RS14535	COG5410	chromosome segregation
E3165_RS14560	COG3772	lysozyme
E3165_RS14790	COG0629	single-stranded DNA binding
E3165_RS14805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3165_RS14825	COG0305	Participates in initiation and elongation during chromosome replication
E3165_RS14855	COG0583	DNA-binding transcription factor activity
E3165_RS14860	COG1073	alpha beta
E3165_RS14865	COG1073	alpha beta
E3165_RS14870	COG1073	alpha beta
E3165_RS14875	COG0702	epimerase
E3165_RS14880	COG2866	Carboxypeptidase
E3165_RS14885	COG4948	Mandelate Racemase Muconate Lactonizing
E3165_RS14890	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E3165_RS14895	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E3165_RS14905	COG3106	COG3106 Predicted ATPase
E3165_RS14910	COG1609	Transcriptional regulator
E3165_RS14920	COG3842	ATPase activity
E3165_RS14925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3165_RS14930	COG1554	hydrolase, family 65, central catalytic
E3165_RS14935	COG0673	inositol 2-dehydrogenase activity
E3165_RS14940	COG1082	Xylose isomerase domain protein TIM barrel
E3165_RS14945	COG1063	alcohol dehydrogenase
E3165_RS14950	COG0395	ABC-type sugar transport system, permease component
E3165_RS14955	COG1175	transmembrane transport
E3165_RS14970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3165_RS14980	COG1983	PspC domain protein
E3165_RS14990	COG1842	Phage shock protein A
E3165_RS14995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E3165_RS15000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3165_RS15005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3165_RS15010	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS15015	COG1396	sequence-specific DNA binding
E3165_RS15015	COG1917	Cupin 2, conserved barrel domain protein
E3165_RS15020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3165_RS15025	COG0174	glutamine synthetase
E3165_RS15035	COG0531	amino acid
E3165_RS15045	COG4166	transmembrane transport
E3165_RS15050	COG4168	peptide transport system, permease
E3165_RS15055	COG4171	peptide transport system, permease
E3165_RS15060	COG4172	Belongs to the ABC transporter superfamily
E3165_RS15065	COG4172	Belongs to the ABC transporter superfamily
E3165_RS15070	COG2814	Major facilitator Superfamily
E3165_RS15085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS15095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3165_RS15100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3165_RS15100	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3165_RS15110	COG5001	Diguanylate cyclase
E3165_RS15120	COG1349	DNA-binding transcription factor activity
E3165_RS15130	COG0023	Translation Initiation Factor
E3165_RS15140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E3165_RS15145	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E3165_RS15150	COG0671	phosphoesterase, PA-phosphatase related
E3165_RS15160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3165_RS15180	COG0583	DNA-binding transcription factor activity
E3165_RS15185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3165_RS15195	COG0616	signal peptide processing
E3165_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS15205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E3165_RS15210	COG1187	pseudouridine synthase activity
E3165_RS15215	COG4907	membrane protein (DUF2207)
E3165_RS15220	COG0009	L-threonylcarbamoyladenylate synthase
E3165_RS15225	COG0613	PHP domain protein
E3165_RS15235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3165_RS15240	COG0512	Glutamine amidotransferase of anthranilate synthase
E3165_RS15240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3165_RS15245	COG0134	indole-3-glycerol-phosphate synthase activity
E3165_RS15245	COG0135	phosphoribosylanthranilate isomerase activity
E3165_RS15260	COG3729	General stress protein
E3165_RS15265	COG3685	Protein conserved in bacteria
E3165_RS15270	COG3685	Protein conserved in bacteria
E3165_RS15275	COG3047	cAMP biosynthetic process
E3165_RS15295	COG1607	acyl-coa hydrolase
E3165_RS15300	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E3165_RS15305	COG2350	Protein conserved in bacteria
E3165_RS15310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3165_RS15330	COG4608	Belongs to the ABC transporter superfamily
E3165_RS15335	COG0444	Belongs to the ABC transporter superfamily
E3165_RS15340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3165_RS15345	COG0601	transmembrane transport
E3165_RS15350	COG4166	transmembrane transport
E3165_RS15355	COG2095	MarC family integral membrane protein
E3165_RS15360	COG1454	alcohol dehydrogenase
E3165_RS15360	COG1012	belongs to the aldehyde dehydrogenase family
E3165_RS15365	COG1435	thymidine kinase activity
E3165_RS15375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3165_RS15380	COG0745	RESPONSE REGULATOR receiver
E3165_RS15385	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3165_RS15395	COG0788	formyltetrahydrofolate deformylase activity
E3165_RS15425	COG2181	nitrate reductase activity
E3165_RS15430	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3165_RS15435	COG1140	nitrate reductase beta subunit
E3165_RS15440	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3165_RS15445	COG2223	nitrite transmembrane transporter activity
E3165_RS15450	COG3850	Histidine kinase
E3165_RS15455	COG2197	response regulator
E3165_RS15460	COG4932	domain protein
E3165_RS15465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E3165_RS15470	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E3165_RS15475	COG4572	Cation transport regulator
E3165_RS15480	COG0387	Pfam Sodium calcium exchanger
E3165_RS15500	COG2912	Transglutaminase-like superfamily
E3165_RS15505	COG3094	Invasion gene expression up-regulator, SirB
E3165_RS15535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3165_RS15540	COG0659	secondary active sulfate transmembrane transporter activity
E3165_RS15555	COG0012	GTP binding
E3165_RS15560	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS15565	COG3284	Transcriptional regulator
E3165_RS15570	COG2376	Dihydroxyacetone kinase
E3165_RS15575	COG1461	Dihydroxyacetone kinase
E3165_RS15580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS15580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3165_RS15580	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E3165_RS15605	COG1120	ATPase activity
E3165_RS15610	COG0500	methyltransferase
E3165_RS15615	COG0157	Belongs to the NadC ModD family
E3165_RS15630	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E3165_RS15640	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3165_RS15660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3165_RS15670	COG2719	SpoVR family
E3165_RS15685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3165_RS15690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3165_RS15695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3165_RS15710	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3165_RS15740	COG2894	cell division
E3165_RS15750	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS15790	COG2200	EAL domain
E3165_RS15815	COG2200	EAL domain
E3165_RS15820	COG0789	Transcriptional regulator
E3165_RS15825	COG5562	phage envelope protein
E3165_RS15840	COG0538	isocitrate dehydrogenase activity
E3165_RS15845	COG0456	acetyltransferase
E3165_RS15855	COG4571	Outer membrane protease
E3165_RS15870	COG0500	methyltransferase
E3165_RS15875	COG3729	General stress protein
E3165_RS15880	COG3685	Protein conserved in bacteria
E3165_RS15885	COG3685	Protein conserved in bacteria
E3165_RS15890	COG3546	catalase activity
E3165_RS15895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3165_RS15900	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS15935	COG1196	nuclear chromosome segregation
E3165_RS15985	COG1030	water channel activity
E3165_RS16005	COG4220	transposase activity
E3165_RS16020	COG5562	phage envelope protein
E3165_RS16055	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS16075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3165_RS16085	COG2076	Multidrug Resistance protein
E3165_RS16170	COG0582	viral genome integration into host DNA
E3165_RS16175	COG0538	isocitrate dehydrogenase activity
E3165_RS16180	COG1187	pseudouridine synthase activity
E3165_RS16190	COG0482	sulfurtransferase activity
E3165_RS16200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3165_RS16205	COG0745	RESPONSE REGULATOR receiver
E3165_RS16210	COG2205	protein histidine kinase activity
E3165_RS16220	COG4220	transposase activity
E3165_RS16310	COG2850	peptidyl-arginine hydroxylation
E3165_RS16320	COG3842	ATPase activity
E3165_RS16385	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS16545	COG3772	lysozyme
E3165_RS16585	COG0484	heat shock protein binding
E3165_RS16590	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS16595	COG1403	HNH endonuclease
E3165_RS16650	COG1846	Transcriptional regulator
E3165_RS16670	COG4197	protein conserved in bacteria, prophage-related
E3165_RS16700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS16710	COG0582	viral genome integration into host DNA
E3165_RS16715	COG1177	transmembrane transport
E3165_RS16720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3165_RS16725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3165_RS16735	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3165_RS16740	COG1136	(ABC) transporter
E3165_RS16745	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3165_RS16750	COG4763	Acyl-transferase
E3165_RS16755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3165_RS16760	COG1388	LysM domain
E3165_RS16760	COG1376	ErfK ybiS ycfS ynhG family protein
E3165_RS16770	COG1309	transcriptional regulator
E3165_RS16775	COG3134	Outer membrane lipoprotein
E3165_RS16780	COG1252	NADH dehydrogenase
E3165_RS16795	COG0510	thiamine kinase activity
E3165_RS16800	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E3165_RS16805	COG5633	Lipoprotein
E3165_RS16810	COG0537	adenosine 5'-monophosphoramidase activity
E3165_RS16815	COG4773	Receptor
E3165_RS16820	COG1263	PTS System
E3165_RS16820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS16825	COG0084	hydrolase, TatD family'
E3165_RS16830	COG0470	DNA polymerase III
E3165_RS16840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3165_RS16845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3165_RS16850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3165_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS16865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3165_RS16885	COG1399	metal-binding, possibly nucleic acid-binding protein
E3165_RS16890	COG0424	maF-like protein
E3165_RS16895	COG0564	pseudouridine synthase activity
E3165_RS16900	COG1530	ribonuclease E activity
E3165_RS16905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3165_RS16910	COG1256	bacterial-type flagellum assembly
E3165_RS16915	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3165_RS16915	COG3951	Flagellar rod assembly protein muramidase FlgJ
E3165_RS16930	COG4786	Flagellar basal body rod
E3165_RS16935	COG4787	bacterial-type flagellum-dependent cell motility
E3165_RS16940	COG1749	Flagellar hook protein flgE
E3165_RS16945	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3165_RS16950	COG1558	bacterial-type flagellum-dependent cell motility
E3165_RS16955	COG1815	bacterial-type flagellum-dependent cell motility
E3165_RS16960	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E3165_RS16965	COG2747	anti-sigma28 factor FlgM
E3165_RS16970	COG3418	PFAM FlgN family protein
E3165_RS16975	COG0728	peptidoglycan biosynthetic process
E3165_RS16980	COG0673	inositol 2-dehydrogenase activity
E3165_RS16990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3165_RS17000	COG2999	glutathione oxidoreductase activity
E3165_RS17035	COG3038	cytochrome b561
E3165_RS17040	COG2353	YceI-like domain
E3165_RS17050	COG1560	Kdo2-lipid A biosynthetic process
E3165_RS17065	COG5645	(Lipo)protein
E3165_RS17070	COG2943	transferase activity, transferring hexosyl groups
E3165_RS17085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3165_RS17090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3165_RS17115	COG2197	response regulator
E3165_RS17130	COG1462	curli production assembly transport component CsgG
E3165_RS17140	COG3381	protein complex oligomerization
E3165_RS17205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3165_RS17210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3165_RS17220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3165_RS17230	COG0736	holo-[acyl-carrier-protein] synthase activity
E3165_RS17235	COG2831	hemolysin activation secretion protein
E3165_RS17240	COG3210	domain, Protein
E3165_RS17250	COG3539	Fimbrial protein
E3165_RS17260	COG3188	usher protein
E3165_RS17270	COG3121	Chaperone
E3165_RS17275	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS17280	COG3710	Transcriptional regulator
E3165_RS17290	COG2200	EAL domain
E3165_RS17295	COG3706	GGDEF domain
E3165_RS17300	COG0457	Tetratricopeptide repeat
E3165_RS17310	COG1215	transferase activity, transferring glycosyl groups
E3165_RS17315	COG3658	cytochrome
E3165_RS17320	COG1702	phosphate starvation-inducible protein PhoH
E3165_RS17325	COG2837	iron assimilation
E3165_RS17330	COG2822	iron ion transport
E3165_RS17345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3165_RS17355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3165_RS17355	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3165_RS17355	COG0506	proline dehydrogenase activity
E3165_RS17360	COG1309	transcriptional regulator
E3165_RS17395	COG2233	PERMEase
E3165_RS17400	COG3729	General stress protein
E3165_RS17440	COG0243	molybdopterin cofactor binding
E3165_RS17445	COG3005	denitrification pathway
E3165_RS17450	COG0745	RESPONSE REGULATOR receiver
E3165_RS17455	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS17460	COG2205	protein histidine kinase activity
E3165_RS17460	COG2198	Histidine kinase
E3165_RS17460	COG0784	Response regulator, receiver
E3165_RS17465	COG0348	domain, Protein
E3165_RS17485	COG1278	Cold shock
E3165_RS17490	COG1278	Cold shock
E3165_RS17510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3165_RS17515	COG1596	polysaccharide export
E3165_RS17520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3165_RS17525	COG3206	protein involved in exopolysaccharide biosynthesis
E3165_RS17525	COG0489	protein tyrosine kinase activity
E3165_RS17540	COG1294	oxidase, subunit
E3165_RS17545	COG1271	oxidase subunit
E3165_RS17550	COG1773	rubredoxin
E3165_RS17555	COG1999	signal sequence binding
E3165_RS17560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3165_RS17565	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E3165_RS17570	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3165_RS17575	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3165_RS17595	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS17615	COG2032	superoxide dismutase activity
E3165_RS17710	COG4220	transposase activity
E3165_RS17740	COG3772	lysozyme
E3165_RS17775	COG2207	Transcriptional regulator
E3165_RS17795	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS17800	COG1403	HNH endonuclease
E3165_RS17830	COG1846	Transcriptional regulator
E3165_RS17835	COG1484	DNA-dependent DNA replication
E3165_RS17900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS17915	COG0670	Belongs to the BI1 family
E3165_RS17920	COG2920	part of a sulfur-relay system
E3165_RS17925	COG1254	Belongs to the acylphosphatase family
E3165_RS17940	COG1832	CoA-binding protein
E3165_RS17955	COG0210	DNA helicase
E3165_RS17960	COG3304	Inner membrane component domain
E3165_RS17965	COG1289	transmembrane transporter activity
E3165_RS17970	COG3070	regulator of competence-specific genes
E3165_RS17980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3165_RS17980	COG2885	chlorophyll binding
E3165_RS17990	COG1067	ATP-dependent peptidase activity
E3165_RS18000	COG3130	regulation of translation
E3165_RS18005	COG3009	Protein conserved in bacteria
E3165_RS18010	COG3008	intermembrane lipid transfer
E3165_RS18010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3165_RS18015	COG2995	paraquat-inducible protein a
E3165_RS18020	COG0488	(ABC) transporter
E3165_RS18030	COG3217	Mosc domain protein beta barrel domain protein
E3165_RS18030	COG0633	Ferredoxin
E3165_RS18045	COG3121	Chaperone
E3165_RS18050	COG3539	Fimbrial protein
E3165_RS18055	COG3539	Fimbrial protein
E3165_RS18060	COG3539	Fimbrial protein
E3165_RS18070	COG3121	Chaperone
E3165_RS18075	COG3539	Fimbrial protein
E3165_RS18080	COG0431	NADPH-dependent FMN reductase
E3165_RS18085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3165_RS18095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3165_RS18100	COG1116	anion transmembrane transporter activity
E3165_RS18105	COG0308	aminopeptidase N
E3165_RS18115	COG0017	Asparaginyl-tRNA synthetase
E3165_RS18120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3165_RS18125	COG1448	Aminotransferase
E3165_RS18130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3165_RS18135	COG3108	Peptidase M15
E3165_RS18140	COG2989	Protein conserved in bacteria
E3165_RS18150	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E3165_RS18160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3165_RS18165	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3165_RS18170	COG3173	Aminoglycoside phosphotransferase
E3165_RS18185	COG3214	Protein conserved in bacteria
E3165_RS18195	COG1132	(ABC) transporter
E3165_RS18200	COG0658	competence protein
E3165_RS18200	COG2333	competence protein COMEC
E3165_RS18210	COG0539	negative regulation of cytoplasmic translation
E3165_RS18220	COG0501	Belongs to the peptidase M48B family
E3165_RS18235	COG2323	membrane
E3165_RS18240	COG1944	ATP diphosphatase activity
E3165_RS18245	COG2116	formate transmembrane transporter activity
E3165_RS18250	COG1882	Formate acetyltransferase
E3165_RS18255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3165_RS18265	COG0531	amino acid
E3165_RS18275	COG1335	isochorismatase
E3165_RS18280	COG3302	dmso reductase anchor subunit
E3165_RS18285	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS18290	COG0243	molybdopterin cofactor binding
E3165_RS18300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3165_RS18315	COG1522	sequence-specific DNA binding
E3165_RS18320	COG0492	ferredoxin-NADP+ reductase activity
E3165_RS18325	COG4988	ABC transporter
E3165_RS18330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3165_RS18350	COG0542	response to heat
E3165_RS18360	COG1278	Cold shock
E3165_RS18365	COG1136	(ABC) transporter
E3165_RS18365	COG0577	efflux transmembrane transporter activity
E3165_RS18370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS18375	COG2990	Protein conserved in bacteria
E3165_RS18380	COG3593	DNA synthesis involved in DNA repair
E3165_RS18385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3165_RS18390	COG2431	L-lysine efflux transmembrane transporter activity
E3165_RS18400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3165_RS18405	COG0028	Belongs to the TPP enzyme family
E3165_RS18410	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E3165_RS18415	COG0702	epimerase
E3165_RS18420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3165_RS18425	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3165_RS18445	COG1126	abc transporter atp-binding protein
E3165_RS18450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS18455	COG4215	(ABC) transporter
E3165_RS18460	COG4160	amino acid transport
E3165_RS18465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS18495	COG1177	transmembrane transport
E3165_RS18500	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3165_RS18505	COG3842	ATPase activity
E3165_RS18510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3165_RS18525	COG0778	Nitroreductase
E3165_RS18535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3165_RS18550	COG3226	Transcriptional regulator
E3165_RS18555	COG0738	Major facilitator superfamily
E3165_RS18560	COG0561	phosphatase activity
E3165_RS18570	COG2814	Major facilitator Superfamily
E3165_RS18575	COG0671	phosphoesterase, PA-phosphatase related
E3165_RS18580	COG1349	DNA-binding transcription factor activity
E3165_RS18585	COG1686	Belongs to the peptidase S11 family
E3165_RS18590	COG0625	glutathione transferase activity
E3165_RS18595	COG2133	pyrroloquinoline quinone binding
E3165_RS18620	COG2199	diguanylate cyclase activity
E3165_RS18625	COG2200	EAL domain
E3165_RS18640	COG0747	negative chemotaxis
E3165_RS18645	COG4172	Belongs to the ABC transporter superfamily
E3165_RS18650	COG1446	asparaginase
E3165_RS18655	COG0303	'Molybdopterin
E3165_RS18660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3165_RS18665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3165_RS18670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3165_RS18675	COG1882	Formate acetyltransferase
E3165_RS18680	COG0561	phosphatase activity
E3165_RS18690	COG0488	(ABC) transporter
E3165_RS18695	COG1376	ErfK ybiS ycfS ynhG family protein
E3165_RS18700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3165_RS18705	COG1321	iron dependent repressor
E3165_RS18715	COG2194	sulfuric ester hydrolase activity
E3165_RS18720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3165_RS18730	COG5006	permease, DMT superfamily
E3165_RS18740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS18745	COG0765	amino acid transport
E3165_RS18750	COG1126	abc transporter atp-binding protein
E3165_RS18755	COG0668	transmembrane transport
E3165_RS18770	COG4774	siderophore transport
E3165_RS18780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3165_RS18790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E3165_RS18795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3165_RS18800	COG1199	ATP-dependent helicase activity
E3165_RS18810	COG0513	Belongs to the DEAD box helicase family
E3165_RS18815	COG1309	transcriptional regulator
E3165_RS18825	COG1131	(ABC) transporter
E3165_RS18830	COG0842	Transport permease protein
E3165_RS18835	COG0842	Transport permease protein
E3165_RS18845	COG3568	Endonuclease Exonuclease Phosphatase
E3165_RS18850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3165_RS18855	COG0392	lysyltransferase activity
E3165_RS18860	COG0670	Belongs to the BI1 family
E3165_RS18865	COG0670	Belongs to the BI1 family
E3165_RS18870	COG0314	molybdopterin synthase activity
E3165_RS18875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3165_RS18885	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3165_RS18895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3165_RS18905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3165_RS18910	COG2226	methyltransferase
E3165_RS18925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3165_RS18930	COG1881	PFAM PEBP family protein
E3165_RS18970	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS19045	COG0740	serine-type endopeptidase activity
E3165_RS19080	COG3772	lysozyme
E3165_RS19275	COG0582	viral genome integration into host DNA
E3165_RS19280	COG4677	pectinesterase activity
E3165_RS19285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3165_RS19290	COG0471	metal ion transport
E3165_RS19295	COG2828	Protein conserved in bacteria
E3165_RS19300	COG0583	DNA-binding transcription factor activity
E3165_RS19310	COG0561	phosphatase activity
E3165_RS19320	COG4149	molybdate abc transporter
E3165_RS19325	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3165_RS19335	COG2005	Transcriptional regulator
E3165_RS19335	COG3585	molybdate ion transport
E3165_RS19340	COG1119	ATPase activity
E3165_RS19345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3165_RS19350	COG1085	galactose-1-phosphate uridylyltransferase
E3165_RS19360	COG2017	converts alpha-aldose to the beta-anomer
E3165_RS19370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3165_RS19380	COG1230	cation diffusion facilitator family transporter
E3165_RS19385	COG3201	nicotinamide mononucleotide transporter
E3165_RS19390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3165_RS19430	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E3165_RS19435	COG2885	chlorophyll binding
E3165_RS19445	COG3064	Membrane
E3165_RS19450	COG0848	biopolymer transport protein
E3165_RS19455	COG0811	peptide transport
E3165_RS19460	COG0824	Thioesterase
E3165_RS19465	COG3790	cyd operon protein YbgE
E3165_RS19470	COG4890	Cyd operon protein YbgT
E3165_RS19475	COG1294	oxidase, subunit
E3165_RS19480	COG1271	oxidase subunit
E3165_RS19495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3165_RS19505	COG4865	methylaspartate mutase activity
E3165_RS19510	COG3799	methylaspartate ammonia-lyase activity
E3165_RS19525	COG1301	dicarboxylic acid transport
E3165_RS19530	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS19530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS19535	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E3165_RS19540	COG0583	DNA-binding transcription factor activity
E3165_RS19545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3165_RS19555	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3165_RS19560	COG0567	Dehydrogenase, E1 component
E3165_RS19565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3165_RS19570	COG1053	succinate dehydrogenase
E3165_RS19575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3165_RS19580	COG2009	succinate dehydrogenase
E3165_RS19590	COG0372	Belongs to the citrate synthase family
E3165_RS19595	COG3539	Fimbrial protein
E3165_RS19605	COG3121	Chaperone
E3165_RS19610	COG3539	Fimbrial protein
E3165_RS19615	COG3180	Ammonia monooxygenase
E3165_RS19620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3165_RS19630	COG1984	allophanate hydrolase subunit 2
E3165_RS19635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3165_RS19640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3165_RS19645	COG3104	oligopeptide transport
E3165_RS19650	COG0415	Belongs to the DNA photolyase family
E3165_RS19655	COG3272	Protein of unknown function (DUF1722)
E3165_RS19660	COG5433	transposase activity
E3165_RS19675	COG3209	COG3209 Rhs family protein
E3165_RS19705	COG2205	protein histidine kinase activity
E3165_RS19710	COG0745	RESPONSE REGULATOR receiver
E3165_RS19720	COG1982	Orn Lys Arg decarboxylase major
E3165_RS19725	COG0531	amino acid
E3165_RS19730	COG0033	Phosphoglucomutase
E3165_RS19735	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E3165_RS19740	COG0596	Alpha beta hydrolase
E3165_RS19750	COG0716	FMN binding
E3165_RS19760	COG0735	belongs to the Fur family
E3165_RS19780	COG2190	(PTS) system
E3165_RS19780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS19780	COG1263	PTS System
E3165_RS19790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3165_RS19795	COG1846	Transcriptional regulator
E3165_RS19795	COG1940	carbohydrate kinase activity
E3165_RS19800	COG0647	UMP catabolic process
E3165_RS19805	COG0367	asparagine synthase
E3165_RS19845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3165_RS19855	COG1702	phosphate starvation-inducible protein PhoH
E3165_RS19865	COG4535	Mg2 and Co2 transporter CorC
E3165_RS19870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3165_RS19875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3165_RS19880	COG0765	amino acid transport
E3165_RS19885	COG0765	amino acid transport
E3165_RS19890	COG1126	abc transporter atp-binding protein
E3165_RS19900	COG0443	Heat shock 70 kDa protein
E3165_RS19915	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3165_RS19920	COG2214	Heat shock protein DnaJ domain protein
E3165_RS19935	COG2888	peptidyl-tyrosine sulfation
E3165_RS19950	COG1466	dna polymerase III delta subunit
E3165_RS19960	COG0406	alpha-ribazole phosphatase activity
E3165_RS19965	COG0799	negative regulation of ribosome biogenesis
E3165_RS19975	COG0768	penicillin binding
E3165_RS19980	COG0772	Belongs to the SEDS family
E3165_RS19985	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3165_RS19990	COG1686	Belongs to the peptidase S11 family
E3165_RS20005	COG0583	DNA-binding transcription factor activity
E3165_RS20015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3165_RS20020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3165_RS20040	COG3069	C4-dicarboxylate transmembrane transporter activity
E3165_RS20045	COG4565	transcriptional regulatory protein
E3165_RS20050	COG3290	protein histidine kinase activity
E3165_RS20055	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E3165_RS20065	COG2301	Belongs to the HpcH HpaI aldolase family
E3165_RS20070	COG3051	citrate lyase alpha subunit
E3165_RS20080	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E3165_RS20085	COG0471	metal ion transport
E3165_RS20090	COG3719	Belongs to the RNase T2 family
E3165_RS20095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3165_RS20100	COG1063	alcohol dehydrogenase
E3165_RS20105	COG0589	response to stress
E3165_RS20110	COG3634	alkyl hydroperoxide reductase activity
E3165_RS20115	COG0450	alkyl hydroperoxide reductase
E3165_RS20120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3165_RS20125	COG0583	DNA-binding transcription factor activity
E3165_RS20130	COG3969	phosphoadenosine phosphosulfate
E3165_RS20135	COG1475	DNA binding
E3165_RS20140	COG0436	Aminotransferase
E3165_RS20145	COG0371	Dehydrogenase
E3165_RS20150	COG2879	small protein
E3165_RS20155	COG1966	Carbon starvation protein
E3165_RS20165	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS20170	COG1535	isochorismatase
E3165_RS20170	COG3433	isochorismatase activity
E3165_RS20175	COG1021	2,3-dihydroxybenzoate-AMP ligase
E3165_RS20180	COG1169	isochorismate synthase
E3165_RS20185	COG4592	Periplasmic binding protein
E3165_RS20195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3165_RS20200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3165_RS20205	COG1120	ATPase activity
E3165_RS20210	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3165_RS20215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3165_RS20215	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E3165_RS20220	COG3251	PFAM MbtH domain protein
E3165_RS20225	COG2382	esterase
E3165_RS20230	COG4771	TonB-dependent receptor
E3165_RS20235	COG2977	Belongs to the P-Pant transferase superfamily
E3165_RS20260	COG2315	Protein conserved in bacteria
E3165_RS20265	COG0778	Nitroreductase
E3165_RS20270	COG0668	transmembrane transport
E3165_RS20275	COG1113	amino acid transport
E3165_RS20280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3165_RS20285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS20290	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS20295	COG1538	Outer membrane efflux protein
E3165_RS20300	COG0745	RESPONSE REGULATOR receiver
E3165_RS20305	COG5002	protein histidine kinase activity
E3165_RS20310	COG3501	Rhs element vgr protein
E3165_RS20320	COG3209	COG3209 Rhs family protein
E3165_RS20320	COG4104	PAAR repeat-containing protein
E3165_RS20330	COG4104	PAAR repeat-containing protein
E3165_RS20330	COG3209	COG3209 Rhs family protein
E3165_RS20340	COG5433	transposase activity
E3165_RS20345	COG1215	transferase activity, transferring glycosyl groups
E3165_RS20350	COG4783	chaperone-mediated protein folding
E3165_RS20360	COG2207	Transcriptional regulator
E3165_RS20370	COG2197	response regulator
E3165_RS20375	COG3539	Fimbrial protein
E3165_RS20380	COG3539	Fimbrial protein
E3165_RS20385	COG3188	usher protein
E3165_RS20390	COG3121	Chaperone
E3165_RS20395	COG3539	Fimbrial protein
E3165_RS20405	COG2501	S4 domain
E3165_RS20410	COG1988	membrane-bound metal-dependent
E3165_RS20420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3165_RS20430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3165_RS20435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3165_RS20440	COG0549	Belongs to the carbamate kinase family
E3165_RS20450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3165_RS20455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3165_RS20460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E3165_RS20470	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS20485	COG2233	PERMEase
E3165_RS20490	COG1929	Belongs to the glycerate kinase type-1 family
E3165_RS20495	COG3257	ureidoglycine aminohydrolase activity
E3165_RS20505	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS20515	COG2084	Dehydrogenase
E3165_RS20520	COG3622	Belongs to the hyi family
E3165_RS20525	COG3960	tartronate-semialdehyde synthase activity
E3165_RS20530	COG1414	Transcriptional regulator
E3165_RS20540	COG0583	DNA-binding transcription factor activity
E3165_RS20565	COG3209	COG3209 Rhs family protein
E3165_RS20570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3165_RS20575	COG4181	ATPase activity
E3165_RS20580	COG2755	lipolytic protein G-D-S-L family
E3165_RS20585	COG0300	oxidoreductase activity
E3165_RS20590	COG3118	belongs to the thioredoxin family
E3165_RS20595	COG0390	transport system, permease component
E3165_RS20600	COG4619	ABC transporter
E3165_RS20605	COG0330	HflC and HflK could
E3165_RS20610	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3165_RS20630	COG0789	Transcriptional regulator
E3165_RS20655	COG0531	amino acid
E3165_RS20660	COG2066	Belongs to the glutaminase family
E3165_RS20665	COG2217	Heavy metal translocating P-type atpase
E3165_RS20670	COG3093	addiction module antidote protein HigA
E3165_RS20675	COG3735	TraB family
E3165_RS20680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3165_RS20685	COG0737	Belongs to the 5'-nucleotidase family
E3165_RS20690	COG2223	nitrite transmembrane transporter activity
E3165_RS20695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3165_RS20695	COG4651	solute:proton antiporter activity
E3165_RS20700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS20735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3165_RS20745	COG2832	Protein of unknown function (DUF454)
E3165_RS20750	COG3923	Primosomal replication protein n
E3165_RS20760	COG1196	nuclear chromosome segregation
E3165_RS20760	COG3264	Mechanosensitive ion channel
E3165_RS20765	COG1309	transcriptional regulator
E3165_RS20770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3165_RS20775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3165_RS20790	COG0110	maltose O-acetyltransferase activity
E3165_RS20800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3165_RS20805	COG5507	3-demethylubiquinone-9 3-methyltransferase
E3165_RS20815	COG3695	enzyme binding
E3165_RS20820	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E3165_RS20825	COG1946	Acyl-CoA thioesterase
E3165_RS20830	COG0004	ammonium transporteR
E3165_RS20835	COG0347	Belongs to the P(II) protein family
E3165_RS20840	COG1132	(ABC) transporter
E3165_RS20845	COG1132	(ABC) transporter
E3165_RS20850	COG1522	sequence-specific DNA binding
E3165_RS20860	COG4533	DNA binding
E3165_RS20870	COG0824	Thioesterase
E3165_RS20875	COG1555	photosystem II stabilization
E3165_RS20880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3165_RS20885	COG0776	regulation of translation
E3165_RS20890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3165_RS20910	COG0271	Belongs to the BolA IbaG family
E3165_RS20915	COG3056	Lipoprotein
E3165_RS20920	COG2223	nitrite transmembrane transporter activity
E3165_RS20925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3165_RS20930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3165_RS20935	COG1845	cytochrome c oxidase, subunit III
E3165_RS20940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3165_RS20950	COG2814	Major facilitator Superfamily
E3165_RS20960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3165_RS20965	COG0693	protein deglycase activity
E3165_RS20980	COG0142	geranyltranstransferase activity
E3165_RS20990	COG0667	Aldo Keto reductase
E3165_RS21000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3165_RS21005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3165_RS21020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3165_RS21020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3165_RS21030	COG4238	major outer membrane lipoprotein
E3165_RS21035	COG3248	Nucleoside-binding outer membrane protein
E3165_RS21040	COG1403	HNH endonuclease
E3165_RS21050	COG3609	addiction module antidote protein, CC2985 family
E3165_RS21055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3165_RS21060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3165_RS21065	COG1862	Preprotein translocase
E3165_RS21090	COG0366	Alpha amylase catalytic
E3165_RS21095	COG1113	amino acid transport
E3165_RS21100	COG1114	Component of the transport system for branched-chain amino acids
E3165_RS21105	COG5002	protein histidine kinase activity
E3165_RS21110	COG0745	RESPONSE REGULATOR receiver
E3165_RS21115	COG0420	3'-5' exonuclease activity
E3165_RS21120	COG0419	ATPase involved in DNA repair
E3165_RS21125	COG2814	Major facilitator Superfamily
E3165_RS21130	COG1940	carbohydrate kinase activity
E3165_RS21155	COG4126	flavin adenine dinucleotide binding
E3165_RS21175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3165_RS21180	COG3706	GGDEF domain
E3165_RS21190	COG1785	Belongs to the alkaline phosphatase family
E3165_RS21205	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3165_RS21225	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E3165_RS21230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3165_RS21235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3165_RS21240	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS21245	COG0113	porphobilinogen synthase activity
E3165_RS21250	COG2175	clavaminate synthase activity
E3165_RS21255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3165_RS21260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E3165_RS21265	COG4521	taurine ABC transporter
E3165_RS21280	COG2271	Major facilitator Superfamily
E3165_RS21285	COG1840	ABC-type Fe3 transport system, periplasmic component
E3165_RS21295	COG3842	ATPase activity
E3165_RS21310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3165_RS21315	COG3122	Protein conserved in bacteria
E3165_RS21320	COG2814	Major facilitator Superfamily
E3165_RS21325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3165_RS21340	COG0596	Alpha beta hydrolase
E3165_RS21355	COG1414	Transcriptional regulator
E3165_RS21360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3165_RS21370	COG1609	Transcriptional regulator
E3165_RS21375	COG3250	beta-galactosidase activity
E3165_RS21380	COG2223	nitrite transmembrane transporter activity
E3165_RS21385	COG0110	maltose O-acetyltransferase activity
E3165_RS21390	COG2807	transmembrane transport
E3165_RS21400	COG0288	reversible hydration of carbon dioxide
E3165_RS21405	COG0583	DNA-binding transcription factor activity
E3165_RS21410	COG0402	S-adenosylhomocysteine deaminase activity
E3165_RS21415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3165_RS21420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3165_RS21425	COG2079	MmgE PrpD family protein
E3165_RS21430	COG0372	Belongs to the citrate synthase family
E3165_RS21435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3165_RS21440	COG3829	transcription factor binding
E3165_RS21450	COG1280	lysine exporter protein (LysE YggA)
E3165_RS21465	COG1064	alcohol dehydrogenase
E3165_RS21475	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS21480	COG1129	ABC transporter
E3165_RS21485	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS21495	COG0402	S-adenosylhomocysteine deaminase activity
E3165_RS21500	COG0549	Belongs to the carbamate kinase family
E3165_RS21510	COG1304	FMN binding
E3165_RS21515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3165_RS21525	COG0666	response to abiotic stimulus
E3165_RS21540	COG2771	luxR family
E3165_RS21540	COG2200	EAL domain
E3165_RS21550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3165_RS21580	COG2200	EAL domain
E3165_RS21580	COG2771	luxR family
E3165_RS21595	COG3468	outer membrane autotransporter barrel domain protein
E3165_RS21605	COG1556	Lactate utilization protein
E3165_RS21610	COG1139	Iron-sulfur cluster binding protein
E3165_RS21615	COG0247	lactate metabolic process
E3165_RS21620	COG2207	Transcriptional regulator
E3165_RS21625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3165_RS21635	COG3059	membrane
E3165_RS21640	COG0656	L-ascorbic acid biosynthetic process
E3165_RS21645	COG3708	Transcriptional regulator
E3165_RS21645	COG2207	Transcriptional regulator
E3165_RS21650	COG1388	LysM domain
E3165_RS21665	COG0583	DNA-binding transcription factor activity
E3165_RS21670	COG1073	alpha beta
E3165_RS21675	COG1902	pentaerythritol trinitrate reductase activity
E3165_RS21715	COG3188	usher protein
E3165_RS21725	COG3121	Chaperone
E3165_RS21730	COG0727	PFAM Uncharacterised protein family (UPF0153)
E3165_RS21740	COG3477	response to acidic pH
E3165_RS21745	COG2080	2 iron, 2 sulfur cluster binding
E3165_RS21750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3165_RS21755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3165_RS21760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3165_RS21775	COG0583	DNA-binding transcription factor activity
E3165_RS21785	COG4221	oxidoreductase activity
E3165_RS21790	COG0583	DNA-binding transcription factor activity
E3165_RS21865	COG0582	viral genome integration into host DNA
E3165_RS21905	COG2003	Belongs to the UPF0758 family
E3165_RS21950	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS22000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3165_RS22025	COG4771	TonB-dependent receptor
E3165_RS22030	COG4372	Transposase
E3165_RS22105	COG1358	cellular component organization or biogenesis
E3165_RS22150	COG0758	DNA mediated transformation
E3165_RS22150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3165_RS22170	COG4983	Phage plasmid primase, P4 family domain protein
E3165_RS22175	COG4983	Phage plasmid primase, P4 family domain protein
E3165_RS22210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3165_RS22230	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3165_RS22235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3165_RS22240	COG1690	Belongs to the RtcB family
E3165_RS22245	COG0454	-acetyltransferase
E3165_RS22255	COG2161	toxin-antitoxin pair type II binding
E3165_RS22260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3165_RS22280	COG0791	NLP P60 protein
E3165_RS22285	COG3077	Addiction module antitoxin, RelB DinJ family
E3165_RS22290	COG3041	Addiction module toxin RelE StbE family
E3165_RS22295	COG3034	peptidoglycan biosynthetic process
E3165_RS22300	COG0121	glutamine amidotransferase
E3165_RS22310	COG1960	acyl-CoA dehydrogenase activity
E3165_RS22320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3165_RS22325	COG5433	transposase activity
E3165_RS22340	COG3209	COG3209 Rhs family protein
E3165_RS22345	COG5433	transposase activity
E3165_RS22355	COG3209	COG3209 Rhs family protein
E3165_RS22365	COG3209	COG3209 Rhs family protein
E3165_RS22370	COG3501	Rhs element vgr protein
E3165_RS22485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3165_RS22495	COG2226	methyltransferase
E3165_RS22505	COG1388	LysM domain
E3165_RS22505	COG0741	lytic transglycosylase activity
E3165_RS22510	COG2226	methyltransferase
E3165_RS22520	COG0583	DNA-binding transcription factor activity
E3165_RS22525	COG0656	L-ascorbic acid biosynthetic process
E3165_RS22560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3165_RS22565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3165_RS22570	COG2011	ABC-type metal ion transport system permease component
E3165_RS22575	COG1464	Belongs to the NlpA lipoprotein family
E3165_RS22585	COG1720	tRNA m6t6A37 methyltransferase activity
E3165_RS22595	COG0791	NLP P60 protein
E3165_RS22600	COG3015	lipoprotein NlpE involved in copper resistance
E3165_RS22605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3165_RS22610	COG4681	YaeQ
E3165_RS22620	COG4568	rho-dependent transcription termination
E3165_RS22625	COG0037	tRNA processing
E3165_RS22630	COG0346	lactoylglutathione lyase activity
E3165_RS22645	COG0587	DNA-directed DNA polymerase activity
E3165_RS22670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3165_RS22675	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E3165_RS22685	COG0750	zinc metalloprotease
E3165_RS22690	COG0575	Belongs to the CDS family
E3165_RS22695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3165_RS22700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3165_RS22725	COG0024	Methionine aminopeptidase
E3165_RS22745	COG3835	regulator
E3165_RS22750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3165_RS22765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3165_RS22770	COG2860	membrane
E3165_RS22795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3165_RS22800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3165_RS22805	COG1120	ATPase activity
E3165_RS22810	COG4774	siderophore transport
E3165_RS22815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3165_RS22820	COG1643	Atp-dependent helicase
E3165_RS22825	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E3165_RS22835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3165_RS22840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3165_RS22845	COG0617	tRNA 3'-terminal CCA addition
E3165_RS22850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3165_RS22860	COG3121	Chaperone
E3165_RS22865	COG3188	usher protein
E3165_RS22870	COG3539	Fimbrial protein
E3165_RS22875	COG3539	Fimbrial protein
E3165_RS22900	COG5464	transposase or invertase
E3165_RS22910	COG0726	polysaccharide deacetylase
E3165_RS22915	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS22920	COG0842	Transport permease protein
E3165_RS22925	COG1131	(ABC) transporter
E3165_RS22930	COG0288	reversible hydration of carbon dioxide
E3165_RS22935	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E3165_RS22940	COG4993	Dehydrogenase
E3165_RS22945	COG2132	Multicopper oxidase
E3165_RS22970	COG1049	propionate catabolic process, 2-methylcitrate cycle
E3165_RS22975	COG3064	Membrane
E3165_RS22980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3165_RS22985	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3165_RS22990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3165_RS22995	COG2186	Transcriptional regulator
E3165_RS23005	COG3725	Membrane protein required for beta-lactamase induction
E3165_RS23010	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3165_RS23015	COG0157	Belongs to the NadC ModD family
E3165_RS23020	COG4969	Belongs to the N-Me-Phe pilin family
E3165_RS23025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3165_RS23030	COG1459	type II secretion system
E3165_RS23040	COG0237	dephospho-CoA kinase activity
E3165_RS23055	COG0494	nUDIX hydrolase
E3165_RS23075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3165_RS23080	COG0849	cell division
E3165_RS23085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3165_RS23090	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3165_RS23105	COG0772	Belongs to the SEDS family
E3165_RS23110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3165_RS23120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3165_RS23125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3165_RS23130	COG0768	penicillin binding
E3165_RS23135	COG3116	cell division
E3165_RS23150	COG1609	Transcriptional regulator
E3165_RS23160	COG0440	acetolactate synthase activity
E3165_RS23165	COG0028	Belongs to the TPP enzyme family
E3165_RS23170	COG0583	DNA-binding transcription factor activity
E3165_RS23185	COG0473	3-isopropylmalate dehydrogenase activity
E3165_RS23205	COG4533	DNA binding
E3165_RS23215	COG4143	(ABC) transporter
E3165_RS23220	COG1178	ABC-type Fe3 transport system permease component
E3165_RS23225	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E3165_RS23230	COG0586	Pfam SNARE associated Golgi protein
E3165_RS23235	COG4977	sequence-specific DNA binding
E3165_RS23250	COG0235	Class ii aldolase
E3165_RS23255	COG0417	DNA replication proofreading
E3165_RS23265	COG0564	pseudouridine synthase activity
E3165_RS23275	COG1357	PFAM Pentapeptide repeats (8 copies)
E3165_RS23280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3165_RS23285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3165_RS23290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3165_RS23325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3165_RS23340	COG2271	Major facilitator Superfamily
E3165_RS23345	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3165_RS23350	COG0644	oxidoreductase
E3165_RS23400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3165_RS23405	COG0505	Belongs to the CarA family
E3165_RS23425	COG1047	Peptidyl-prolyl cis-trans
E3165_RS23440	COG0196	riboflavin kinase activity
E3165_RS23465	COG3121	Chaperone
E3165_RS23470	COG3188	usher protein
E3165_RS23480	COG0583	DNA-binding transcription factor activity
E3165_RS23510	COG4735	regulation of single-species biofilm formation
E3165_RS23515	COG1584	GPR1 FUN34 yaaH family protein
E3165_RS23520	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3165_RS23525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3165_RS23530	COG1115	amino acid carrier protein
E3165_RS23545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3165_RS23555	COG0527	aspartate kinase activity
E3165_RS23555	COG0460	homoserine dehydrogenase
E3165_RS23565	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E3165_RS23575	COG0745	RESPONSE REGULATOR receiver
E3165_RS23580	COG4452	Inner membrane protein CreD
E3165_RS23585	COG2205	protein histidine kinase activity
E3165_RS23590	COG0745	RESPONSE REGULATOR receiver
E3165_RS23595	COG3045	CreA protein
E3165_RS23600	COG3708	Transcriptional regulator
E3165_RS23600	COG2207	Transcriptional regulator
E3165_RS23610	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E3165_RS23620	COG0741	lytic transglycosylase activity
E3165_RS23625	COG0488	(ABC) transporter
E3165_RS23635	COG1056	cytidyltransferase-related domain
E3165_RS23635	COG3172	ATPase kinase involved in NAD metabolism
E3165_RS23640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3165_RS23645	COG0560	Phosphoserine phosphatase
E3165_RS23650	COG3726	membrane protein affecting hemolysin expression
E3165_RS23655	COG0095	Lipoate-protein ligase
E3165_RS23655	COG3726	membrane protein affecting hemolysin expression
E3165_RS23690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3165_RS23695	COG0084	hydrolase, TatD family'
E3165_RS23700	COG4667	esterase of the alpha-beta hydrolase superfamily
E3165_RS23710	COG2823	Periplasmic or secreted lipoprotein
E3165_RS23720	COG1011	Hydrolase
E3165_RS23725	COG0456	acetyltransferase
E3165_RS23730	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E3165_RS23750	COG4114	ferric iron reductase
E3165_RS23755	COG2197	response regulator
E3165_RS23760	COG2197	response regulator
E3165_RS23765	COG2966	Psort location CytoplasmicMembrane, score
E3165_RS23780	COG1484	DNA-dependent DNA replication
E3165_RS23795	COG1063	alcohol dehydrogenase
E3165_RS23800	COG1802	Transcriptional regulator
E3165_RS23805	COG2271	Major facilitator Superfamily
E3165_RS23810	COG0840	transmembrane signaling receptor activity
E3165_RS23820	COG1966	Carbon starvation protein
E3165_RS23825	COG2879	small protein
E3165_RS23830	COG0523	cobalamin synthesis protein
E3165_RS23855	COG0732	type I restriction modification DNA specificity domain
E3165_RS23875	COG5457	Domain of unknown function (DUF1127)
E3165_RS23880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3165_RS23885	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS23900	COG5464	transposase or invertase
E3165_RS23905	COG2814	Major facilitator Superfamily
E3165_RS23910	COG2733	membrane
E3165_RS23915	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E3165_RS23920	COG1924	4 iron, 4 sulfur cluster binding
E3165_RS23935	COG3204	pilus organization
E3165_RS23940	COG0477	Major facilitator Superfamily
E3165_RS23945	COG1470	cell adhesion involved in biofilm formation
E3165_RS23945	COG1388	LysM domain
E3165_RS23955	COG3366	ferrous iron transmembrane transporter activity
E3165_RS23960	COG0700	Nucleoside recognition
E3165_RS23965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3165_RS23990	COG2186	Transcriptional regulator
E3165_RS23995	COG0246	Mannitol dehydrogenase
E3165_RS24005	COG2610	gluconate transmembrane transporter activity
E3165_RS24010	COG3539	Fimbrial protein
E3165_RS24015	COG3539	Fimbrial protein
E3165_RS24020	COG3539	Fimbrial protein
E3165_RS24025	COG3188	usher protein
E3165_RS24030	COG3121	Chaperone
E3165_RS24035	COG3539	Fimbrial protein
E3165_RS24040	COG3539	Fimbrial protein
E3165_RS24045	COG4974	Belongs to the 'phage' integrase family
E3165_RS24050	COG0582	viral genome integration into host DNA
E3165_RS24055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3165_RS24060	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E3165_RS24075	COG0210	DNA helicase
E3165_RS24080	COG1205	dead DEAH box helicase
E3165_RS24080	COG1111	helicase
E3165_RS24090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3165_RS24135	COG0582	viral genome integration into host DNA
E3165_RS24145	COG1064	alcohol dehydrogenase
E3165_RS24150	COG0433	COG0433 Predicted ATPase
E3165_RS24155	COG0795	lipopolysaccharide-transporting ATPase activity
E3165_RS24160	COG0795	lipopolysaccharide-transporting ATPase activity
E3165_RS24170	COG2927	DNA polymerase III (CHI subunit)
E3165_RS24180	COG4269	membrane
E3165_RS24185	COG0456	acetyltransferase
E3165_RS24190	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E3165_RS24195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3165_RS24205	COG2731	YhcH YjgK YiaL family protein
E3165_RS24210	COG1309	transcriptional regulator
E3165_RS24215	COG1028	Short-chain dehydrogenase reductase Sdr
E3165_RS24220	COG0251	oxidation-reduction process
E3165_RS24240	COG0251	oxidation-reduction process
E3165_RS24245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3165_RS24255	COG1609	Transcriptional regulator
E3165_RS24260	COG1263	PTS System
E3165_RS24260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3165_RS24265	COG0366	Alpha amylase catalytic
E3165_RS24270	COG1328	CTP reductase activity
E3165_RS24275	COG0602	queuosine metabolic process
E3165_RS24280	COG3783	Cytochrome b(562)
E3165_RS24285	COG0312	modulator of DNA gyrase
E3165_RS24295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3165_RS24305	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS24310	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS24315	COG1129	ABC transporter
E3165_RS24320	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS24325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3165_RS24330	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3165_RS24335	COG2336	PFAM SpoVT AbrB
E3165_RS24340	COG2105	PFAM AIG2 family protein
E3165_RS24345	COG2911	Protein conserved in bacteria
E3165_RS24350	COG0729	surface antigen
E3165_RS24360	COG1253	flavin adenine dinucleotide binding
E3165_RS24370	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E3165_RS24380	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3165_RS24385	COG0737	Belongs to the 5'-nucleotidase family
E3165_RS24390	COG1733	regulation of RNA biosynthetic process
E3165_RS24395	COG0702	epimerase
E3165_RS24400	COG0697	spore germination
E3165_RS24410	COG1113	amino acid transport
E3165_RS24415	COG0545	Peptidyl-prolyl cis-trans isomerase
E3165_RS24420	COG3061	Opacity-associated protein A
E3165_RS24430	COG0675	Transposase, IS605 OrfB family
E3165_RS24455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3165_RS24490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS24495	COG3414	Phosphotransferase system galactitol-specific IIB component
E3165_RS24500	COG3037	sugar-specific permease SgaT UlaA
E3165_RS24515	COG1073	alpha beta
E3165_RS24520	COG3650	response to hydrogen peroxide
E3165_RS24530	COG1960	acyl-CoA dehydrogenase activity
E3165_RS24535	COG0754	glutathionylspermidine amidase activity
E3165_RS24540	COG5463	Belongs to the UPF0441 family
E3165_RS24545	COG3766	membrane
E3165_RS24555	COG1842	Phage shock protein A
E3165_RS24560	COG3789	protein conserved in bacteria
E3165_RS24565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3165_RS24570	COG0557	exoribonuclease II activity
E3165_RS24585	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E3165_RS24590	COG0330	HflC and HflK could
E3165_RS24595	COG0330	HflC and HflK could
E3165_RS24600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3165_RS24620	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3165_RS24625	COG0802	atpase or kinase
E3165_RS24630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3165_RS24630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3165_RS24660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3165_RS24675	COG3264	Mechanosensitive ion channel
E3165_RS24675	COG1511	domain protein
E3165_RS24680	COG0531	amino acid
E3165_RS24690	COG1053	succinate dehydrogenase
E3165_RS24695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3165_RS24710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3165_RS24715	COG3040	lipid binding
E3165_RS24720	COG2076	Multidrug Resistance protein
E3165_RS24725	COG5510	response to toxic substance
E3165_RS24730	COG5510	response to toxic substance
E3165_RS24740	COG1509	lysine 2,3-aminomutase activity
E3165_RS24765	COG0531	amino acid
E3165_RS24770	COG3030	protein affecting phage T7 exclusion by the F plasmid
E3165_RS24775	COG1027	Aspartate ammonia-lyase
E3165_RS24780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3165_RS24790	COG4232	protein-disulfide reductase activity
E3165_RS24795	COG1309	transcriptional regulator
E3165_RS24805	COG3710	Transcriptional regulator
E3165_RS24810	COG0531	amino acid
E3165_RS24815	COG1982	Orn Lys Arg decarboxylase major
E3165_RS24820	COG3104	oligopeptide transport
E3165_RS24825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3165_RS24840	COG2388	GCN5-related N-acetyl-transferase
E3165_RS24845	COG3592	Divergent 4Fe-4S mono-cluster
E3165_RS24850	COG3290	protein histidine kinase activity
E3165_RS24855	COG4565	transcriptional regulatory protein
E3165_RS24860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3165_RS24865	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS24865	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3165_RS24870	COG3647	Membrane
E3165_RS24875	COG2211	Major facilitator Superfamily
E3165_RS24880	COG1486	melibiose metabolic process
E3165_RS24885	COG2169	Transcriptional regulator
E3165_RS24890	COG1982	Orn Lys Arg decarboxylase major
E3165_RS24895	COG2207	Transcriptional regulator
E3165_RS24900	COG0531	amino acid
E3165_RS24905	COG2194	sulfuric ester hydrolase activity
E3165_RS24910	COG0745	RESPONSE REGULATOR receiver
E3165_RS24915	COG0642	Histidine kinase
E3165_RS24925	COG0477	Major facilitator Superfamily
E3165_RS24935	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3165_RS24940	COG2824	Alkylphosphonate utilization operon protein PhnA
E3165_RS24945	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E3165_RS24950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3165_RS24955	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E3165_RS24960	COG3639	organic phosphonate transmembrane transporter activity
E3165_RS24965	COG2188	Transcriptional regulator
E3165_RS24970	COG3624	Phosphonate C-P lyase system protein PhnG
E3165_RS24975	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E3165_RS24980	COG3626	phosphonate metabolism
E3165_RS24985	COG3627	carbon phosphorus lyase activity
E3165_RS24990	COG4107	phosphonate C-P lyase system protein PhnK
E3165_RS24995	COG4778	phosphonate C-P lyase system protein PhnL
E3165_RS25000	COG3454	Phosphonate metabolism
E3165_RS25005	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E3165_RS25010	COG0456	acetyltransferase
E3165_RS25015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3165_RS25030	COG1129	ABC transporter
E3165_RS25035	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS25055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS25065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E3165_RS25075	COG1566	PFAM secretion protein HlyD family protein
E3165_RS25080	COG1289	transmembrane transporter activity
E3165_RS25085	COG1538	Outer membrane efflux protein
E3165_RS25095	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3165_RS25100	COG1301	dicarboxylic acid transport
E3165_RS25105	COG4235	cytochrome complex assembly
E3165_RS25110	COG3088	subunit of a heme lyase
E3165_RS25115	COG1138	Cytochrome C-type biogenesis protein
E3165_RS25120	COG3301	Polysulphide reductase, NrfD
E3165_RS25125	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS25130	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E3165_RS25140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3165_RS25145	COG3162	membrane
E3165_RS25155	COG1357	PFAM Pentapeptide repeats (8 copies)
E3165_RS25160	COG0025	NhaP-type Na H and K H
E3165_RS25165	COG2252	PERMEase
E3165_RS25170	COG0789	Transcriptional regulator
E3165_RS25175	COG2207	Transcriptional regulator
E3165_RS25180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3165_RS25190	COG0629	single-stranded DNA binding
E3165_RS25195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3165_RS25200	COG2315	Protein conserved in bacteria
E3165_RS25205	COG0432	Pfam Uncharacterised protein family UPF0047
E3165_RS25210	COG3700	Belongs to the class B bacterial acid phosphatase family
E3165_RS25220	COG1448	Aminotransferase
E3165_RS25225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3165_RS25230	COG0305	Participates in initiation and elongation during chromosome replication
E3165_RS25235	COG0604	alcohol dehydrogenase
E3165_RS25245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3165_RS25285	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3165_RS25405	COG3772	lysozyme
E3165_RS25440	COG0484	heat shock protein binding
E3165_RS25445	COG1403	HNH endonuclease
E3165_RS25455	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3165_RS25465	COG4725	Belongs to the MT-A70-like family
E3165_RS25475	COG1846	Transcriptional regulator
E3165_RS25490	COG4197	protein conserved in bacteria, prophage-related
E3165_RS25495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3165_RS25515	COG5532	Uncharacterized conserved protein (DUF2303)
E3165_RS25520	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E3165_RS25570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3165_RS25580	COG0735	belongs to the Fur family
E3165_RS25585	COG3237	CsbD-like
E3165_RS25590	COG0534	Mate efflux family protein
E3165_RS25600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3165_RS25635	COG3842	ATPase activity
E3165_RS25640	COG2182	Extracellular solute-binding protein
E3165_RS25645	COG1175	transmembrane transport
E3165_RS25650	COG3833	ABC-type maltose transport systems, permease component
E3165_RS25655	COG2814	Major facilitator Superfamily
E3165_RS25655	COG0477	Major facilitator Superfamily
E3165_RS25675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3165_RS25700	COG0527	aspartate kinase activity
E3165_RS25710	COG1187	pseudouridine synthase activity
E3165_RS25755	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3165_RS25760	COG1410	methionine synthase
E3165_RS25760	COG0646	methionine synthase
E3165_RS25765	COG1414	Transcriptional regulator
E3165_RS25780	COG2224	Isocitrate lyase
E3165_RS25785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3165_RS25795	COG0456	acetyltransferase
E3165_RS25825	COG0151	Belongs to the GarS family
E3165_RS25830	COG2204	response regulator
E3165_RS25835	COG4191	Histidine kinase
E3165_RS25840	COG3678	ATP-independent chaperone mediated protein folding
E3165_RS25855	COG3068	Protein conserved in bacteria
E3165_RS25890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3165_RS25895	COG2104	thiamine diphosphate biosynthetic process
E3165_RS25900	COG2022	thiamine diphosphate biosynthetic process
E3165_RS25905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3165_RS25945	COG0250	Participates in transcription elongation, termination and antitermination
E3165_RS25950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3165_RS25985	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E3165_RS25985	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E3165_RS25990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3165_RS26015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3165_RS26020	COG4206	TonB-dependent receptor
E3165_RS26025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3165_RS26035	COG1309	transcriptional regulator
E3165_RS26040	COG0477	Major facilitator Superfamily
E3165_RS26045	COG1473	amidohydrolase
E3165_RS26055	COG0583	DNA-binding transcription factor activity
E3165_RS26070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3165_RS26085	COG2194	sulfuric ester hydrolase activity
E3165_RS26090	COG2207	Transcriptional regulator
E3165_RS26095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS26100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3165_RS26105	COG1882	Formate acetyltransferase
E3165_RS26110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS26115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS26120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS26120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS26120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3165_RS26125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3165_RS26130	COG0371	Dehydrogenase
E3165_RS26135	COG3738	Protein conserved in bacteria
E3165_RS26145	COG3738	Protein conserved in bacteria
E3165_RS26150	COG0697	spore germination
E3165_RS26160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3165_RS26165	COG0527	aspartate kinase activity
E3165_RS26165	COG0460	homoserine dehydrogenase
E3165_RS26170	COG0626	cystathionine gamma-synthase activity
E3165_RS26180	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E3165_RS26195	COG3209	COG3209 Rhs family protein
E3165_RS26205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3165_RS26210	COG1609	Transcriptional regulator
E3165_RS26215	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3165_RS26230	COG1575	Belongs to the MenA family. Type 1 subfamily
E3165_RS26255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3165_RS26265	COG1494	fructose-1,6-bisphosphatase
E3165_RS26275	COG0589	response to stress
E3165_RS26280	COG3691	Protein conserved in bacteria
E3165_RS26285	COG3152	Membrane
E3165_RS26305	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3165_RS26320	COG3678	ATP-independent chaperone mediated protein folding
E3165_RS26325	COG0745	RESPONSE REGULATOR receiver
E3165_RS26330	COG2205	protein histidine kinase activity
E3165_RS26335	COG2258	MOSC domain
E3165_RS26345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3165_RS26355	COG4977	sequence-specific DNA binding
E3165_RS26355	COG1917	Cupin 2, conserved barrel domain protein
E3165_RS26390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS26395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS26395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3165_RS26400	COG1363	Peptidase, m42
E3165_RS26405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3165_RS26405	COG3711	transcriptional antiterminator
E3165_RS26425	COG0437	4 iron, 4 sulfur cluster binding
E3165_RS26430	COG2864	formate dehydrogenase
E3165_RS26440	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3165_RS26445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3165_RS26460	COG0456	acetyltransferase
E3165_RS26475	COG1011	Hydrolase
E3165_RS26480	COG1349	DNA-binding transcription factor activity
E3165_RS26485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS26490	COG2084	Dehydrogenase
E3165_RS26495	COG3684	Belongs to the aldolase LacD family
E3165_RS26500	COG2942	2-epimerase
E3165_RS26505	COG2017	converts alpha-aldose to the beta-anomer
E3165_RS26515	COG1501	Belongs to the glycosyl hydrolase 31 family
E3165_RS26520	COG2211	Major facilitator Superfamily
E3165_RS26525	COG2211	Major facilitator Superfamily
E3165_RS26530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3165_RS26535	COG2271	Major facilitator Superfamily
E3165_RS26540	COG1082	Xylose isomerase domain protein TIM barrel
E3165_RS26545	COG2188	Transcriptional regulator
E3165_RS26555	COG0174	glutamine synthetase
E3165_RS26560	COG3852	Histidine kinase
E3165_RS26565	COG2204	response regulator
E3165_RS26575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3165_RS26580	COG3078	GTPase activator activity
E3165_RS26590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3165_RS26590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3165_RS26595	COG0204	Acyl-transferase
E3165_RS26600	COG5339	Protein conserved in bacteria
E3165_RS26605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3165_RS26610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3165_RS26615	COG3084	Protein conserved in bacteria
E3165_RS26620	COG0746	molybdenum cofactor guanylyltransferase activity
E3165_RS26625	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3165_RS26655	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E3165_RS26660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3165_RS26665	COG1739	Uncharacterized protein family UPF0029
E3165_RS26680	COG0183	Belongs to the thiolase family
E3165_RS26685	COG0543	2 iron, 2 sulfur cluster binding
E3165_RS26690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3165_RS26695	COG0250	Participates in transcription elongation, termination and antitermination
E3165_RS26700	COG0084	hydrolase, TatD family'
E3165_RS26705	COG0805	protein transport
E3165_RS26710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3165_RS26715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3165_RS26725	COG3165	ubiquinone biosynthetic process from chorismate
E3165_RS26735	COG1322	Protein conserved in bacteria
E3165_RS26740	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E3165_RS26745	COG0412	Dienelactone hydrolase
E3165_RS26755	COG0583	DNA-binding transcription factor activity
E3165_RS26760	COG0697	spore germination
E3165_RS26765	COG0561	phosphatase activity
E3165_RS26770	COG2267	carboxylic ester hydrolase activity
E3165_RS26775	COG1280	lysine exporter protein (LysE YggA)
E3165_RS26780	COG1280	lysine exporter protein (LysE YggA)
E3165_RS26785	COG0514	ATP-dependent DNA helicase (RecQ)
E3165_RS26790	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E3165_RS26795	COG2050	protein possibly involved in aromatic compounds catabolism
E3165_RS26800	COG2962	Rard protein
E3165_RS26825	COG0598	Magnesium transport protein CorA
E3165_RS26830	COG3698	Phosphodiester glycosidase
E3165_RS26835	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E3165_RS26840	COG0210	DNA helicase
E3165_RS26845	COG1011	Hydrolase
E3165_RS26855	COG3159	Protein conserved in bacteria
E3165_RS26865	COG5567	small periplasmic lipoprotein
E3165_RS26875	COG3072	Adenylate cyclase
E3165_RS26885	COG1587	Uroporphyrinogen-III synthase
E3165_RS26890	COG2959	enzyme of heme biosynthesis
E3165_RS26895	COG3071	HemY protein
E3165_RS26900	COG3119	arylsulfatase activity
E3165_RS26905	COG0641	radical SAM
E3165_RS26930	COG1113	amino acid transport
E3165_RS26950	COG2244	polysaccharide biosynthetic process
E3165_RS26955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3165_RS26960	COG0456	acetyltransferase
E3165_RS26965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3165_RS26970	COG1088	dTDP-glucose 4,6-dehydratase activity
E3165_RS26975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3165_RS26980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3165_RS26985	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3165_RS26990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3165_RS26995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3165_RS27005	COG3118	belongs to the thioredoxin family
E3165_RS27020	COG0210	DNA helicase
E3165_RS27025	COG3692	DNA binding
E3165_RS27030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3165_RS27040	COG0583	DNA-binding transcription factor activity
E3165_RS27045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3165_RS27055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3165_RS27060	COG3978	acetolactate synthase activity
E3165_RS27080	COG0606	chelatase, subunit chli
E3165_RS27085	COG3085	chromosome segregation
E3165_RS27125	COG2186	Transcriptional regulator
E3165_RS27130	COG0477	Major facilitator Superfamily
E3165_RS27135	COG1609	Transcriptional regulator
E3165_RS27140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3165_RS27145	COG1879	ABC-type sugar transport system periplasmic component
E3165_RS27150	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3165_RS27155	COG1129	ABC transporter
E3165_RS27165	COG3158	transport of potassium into the cell
E3165_RS27185	COG1522	sequence-specific DNA binding
E3165_RS27190	COG0716	FMN binding
E3165_RS27235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3165_RS27285	COG3736	Type IV secretory pathway, component VirB8
E3165_RS27505	COG2274	protein secretion by the type I secretion system
E3165_RS27680	COG1475	DNA binding
E3165_RS27770	COG2826	transposase and inactivated derivatives, IS30 family
E3165_RS27910	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E3165_RS27960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3165_RS28055	COG0726	polysaccharide deacetylase
E3165_RS28060	COG0297	glycogen (starch) synthase activity
E3165_RS28065	COG2194	sulfuric ester hydrolase activity
E3165_RS28070	COG1560	Kdo2-lipid A biosynthetic process