locus-tag class description E3166_RS00015 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation E3166_RS00065 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E3166_RS00070 ENOG4108ZI2 Fimbrial protein E3166_RS00075 ENOG4108VCD Chaperone E3166_RS00085 ENOG4105CW0 outer membrane usher protein E3166_RS00090 ENOG4105I74 Fimbrial protein E3166_RS00095 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) E3166_RS00100 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) E3166_RS00105 ENOG4105C8U phosphate abc transporter E3166_RS00110 ENOG4105E2Z phosphate ABC transporter (Permease E3166_RS00115 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E3166_RS00120 ENOG4108UTW Plays a role in the regulation of phosphate uptake E3166_RS00145 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 E3166_RS00150 ENOG4105C7N Xanthine uracil vitamin C permease E3166_RS00155 ENOG4108YYH Nadph-dependent fmn reductase E3166_RS00160 ENOG4105E8Q phosphopantetheinyl transferase E3166_RS00175 ENOG4108P6C Tryptophan transporter of low affinity E3166_RS00215 ENOG4105VG0 50S ribosomal protein l34 E3166_RS00230 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E3166_RS00240 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3166_RS00245 ENOG4105VP5 Bacterial protein of unknown function (DUF937) E3166_RS00250 ENOG410667J hydrolase E3166_RS00255 ENOG410657R replicase EC 2.7 E3166_RS00260 ENOG4107WAP fad NAD(P)-binding domain E3166_RS00265 ENOG4105D99 atp gtp-binding protein E3166_RS00270 ENOG4105R2A (LipO)protein E3166_RS00290 ENOG4105FDP GntR family transcriptional regulator E3166_RS00295 ENOG4105CI1 PTS System E3166_RS00300 ENOG4105F8D glycoside hydrolase family 4 E3166_RS00305 ENOG4108AHD Transcriptional regulator E3166_RS00310 ENOG4107RUZ Sss sodium solute transporter superfamily E3166_RS00315 ENOG4105CBG Sulfatase E3166_RS00320 ENOG4106DRA Inner membrane protein YidI E3166_RS00325 ENOG4105VG5 Membrane E3166_RS00330 ENOG4105JP4 Inner membrane protein yidG E3166_RS00335 ENOG4105J13 transcriptional regulator E3166_RS00340 ENOG4105E5M Multidrug resistance protein D E3166_RS00355 ENOG4105C7K acetolactate synthase E3166_RS00360 ENOG4105M71 acetolactate synthase 1 regulatory subunit E3166_RS00380 ENOG4108KX4 response regulator E3166_RS00385 ENOG4105BZU Histidine kinase E3166_RS00390 ENOG4105CXY transporter E3166_RS00395 ENOG4105CXY transporter E3166_RS00410 ENOG4108SAJ Protein of unknown function (DUF1198) E3166_RS00425 ENOG4107RTG Major Facilitator superfamily E3166_RS00430 ENOG4105T8A Uncharacterized protein YicS E3166_RS00435 ENOG4105D01 (LipO)protein E3166_RS00440 ENOG4108UZ3 Transporter E3166_RS00445 ENOG4105S8Q sugar efflux transporter E3166_RS00490 ENOG4108HHI Type III secretion system protein E3166_RS00495 ENOG41083GP type iii secretion E3166_RS00500 ENOG4108TN6 type iii secretion E3166_RS00505 ENOG4108IUF type iii secretion E3166_RS00565 ENOG4108JIR Flagellum-specific ATP synthase E3166_RS00605 ENOG41090V3 Tir chaperone protein (CesT) family E3166_RS00610 ENOG4105TNG K13735 adhesin invasin E3166_RS00620 ENOG4105UQF type iii secretion E3166_RS00665 ENOG4105E5H Transposase E3166_RS00670 ENOG4108YXQ IS66 Orf2 family protein E3166_RS00715 ENOG4105DFP Integrase E3166_RS00725 ENOG4105CT4 transporter E3166_RS00730 ENOG4105CJQ hydrolase, family 31 E3166_RS00735 ENOG4105JV1 AsmA family E3166_RS00740 ENOG4105C2W permease E3166_RS00745 ENOG4105D6U Sodium Glutamate Symporter E3166_RS00755 ENOG4105CB5 ATP-dependent DNA helicase recG E3166_RS00760 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase E3166_RS00765 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E3166_RS00775 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E3166_RS00785 ENOG4105EN6 Membrane E3166_RS00790 ENOG4105F5P DNA-damage-inducible protein d E3166_RS00795 ENOG4105DSJ YicC domain protein E3166_RS00815 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) E3166_RS00820 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E3166_RS00830 ENOG4105KDC 50s ribosomal protein l28 E3166_RS00850 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E3166_RS00855 ENOG4105DKP glycosyl transferase, family 9 E3166_RS00860 ENOG4107RJ7 Glycosyl transferase (Group 1 E3166_RS00865 ENOG4107543 (lipo)polysaccharide E3166_RS00870 ENOG4106AH0 Glycosyl Transferase E3166_RS00875 ENOG4108PDR lipopolysaccharide core biosynthesis protein E3166_RS00880 ENOG4105X1N Glycosyl transferase family 8 E3166_RS00885 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase E3166_RS00890 ENOG4108FRV O-antigen ligase E3166_RS00895 ENOG4105D16 lipopolysaccharide heptosyltransferase i E3166_RS00900 ENOG4105XA0 heptosyltransferase ii E3166_RS00910 ENOG4108SEH involved in lipopolysaccharide biosynthesis E3166_RS00915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E3166_RS00925 ENOG4105K64 Glycosyl transferase, family 2 E3166_RS00930 ENOG4105PXI polysaccharide deacetylase E3166_RS00935 ENOG41063SB peptidase E3166_RS00945 ENOG4107YZP Rhodanese domain protein E3166_RS00950 ENOG4105VW4 glutaredoxin 3 E3166_RS00965 ENOG4105D7W serine acetyltransferase E3166_RS00970 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E3166_RS00980 ENOG41073TP transcriptional regulator E3166_RS00985 ENOG4105DAA L-lactate E3166_RS00990 ENOG4105EUR Domain-Containing protein E3166_RS00995 ENOG4108WY4 inner membrane lipoprotein E3166_RS01000 ENOG4108YYI Protein of unknown function (DUF2810) E3166_RS01010 ENOG4105E61 Mannitol repressor protein E3166_RS01020 ENOG4105CTS PTS system mannitol-specific E3166_RS01025 ENOG4105FP6 Protein of unknown function (DUF3302) E3166_RS01030 ENOG4105EFX secretion protein, HlyD family E3166_RS01045 ENOG4105CNA YD repeat protein E3166_RS01050 ENOG4108U78 Glutathione S-transferase E3166_RS01060 ENOG4105EM7 Selenocysteine-specific translation elongation factor E3166_RS01065 ENOG4105C0A alcohol dehydrogenase E3166_RS01075 ENOG4105C26 Dehydrogenase E3166_RS01080 ENOG4105KK7 inner membrane protein YiaW E3166_RS01085 ENOG4105EFX secretion protein, HlyD family E3166_RS01090 ENOG4108Q2M Transcriptional regulator E3166_RS01095 ENOG4105GNX MltA-interacting MipA family protein E3166_RS01105 ENOG4105CT4 transporter E3166_RS01115 ENOG4105J4Q Transcriptional regulator E3166_RS01120 ENOG4108XIB electron transport protein ysaA E3166_RS01125 ENOG4105JKW Valine--pyruvate aminotransferase E3166_RS01130 ENOG4107T9C Alpha amylase catalytic region E3166_RS01135 ENOG4108UR8 BAX protein E3166_RS01140 ENOG4105T16 Transcriptional regulator (AraC family) E3166_RS01145 ENOG4108HWW ABC transporter E3166_RS01155 ENOG4105DFW ABC transporter E3166_RS01165 ENOG4105CMG Carbohydrate kinase E3166_RS01170 ENOG410688U Inner membrane protein yiaB E3166_RS01175 ENOG4108Z12 YiaAB two helix domain-containing protein E3166_RS01180 ENOG4105MEV Acyl-transferase E3166_RS01200 ENOG41060TC Hok gef cell toxic protein E3166_RS01210 ENOG4105MVF Transcriptional regulator E3166_RS01215 ENOG4106JH6 (LipO)protein E3166_RS01225 ENOG4108ZG0 Ompa motb domain protein E3166_RS01230 ENOG4107QY8 reductase E3166_RS01235 ENOG4105HNP -acetyltransferase E3166_RS01240 ENOG4108R3E Dna-3-methyladenine glycosylase i E3166_RS01245 ENOG4105EAX Putative lipase E3166_RS01250 ENOG4105FCD Major Facilitator E3166_RS01255 ENOG4106EAR Fimbrial protein E3166_RS01260 ENOG4108VCD Chaperone E3166_RS01270 ENOG4105MHR Fimbrial protein E3166_RS01275 ENOG4106UCC Fimbrial protein E3166_RS01280 ENOG4105DIJ Phosphoethanolamine transferase E3166_RS01290 ENOG4105DEF Extracellular solute-binding protein, family 5 E3166_RS01295 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3166_RS01300 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3166_RS01305 ENOG4105C3U ABC transporter E3166_RS01310 ENOG4108JQ7 (ABC) transporter E3166_RS01315 ENOG4105C44 Serine transporter E3166_RS01325 ENOG4105D1V cellulose synthase operon protein YhjU E3166_RS01330 ENOG4105WQA Cellulose biosynthesis protein BcsF E3166_RS01335 ENOG4105U74 cellulose biosynthesis protein BcsE E3166_RS01340 ENOG410661M cytoplasmic protein E3166_RS01355 ENOG4107QZ7 Cellulose synthase catalytic subunit E3166_RS01360 ENOG4107EEX Cellulose synthase regulator protein E3166_RS01365 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) E3166_RS01370 ENOG4105EJG cellulose synthase E3166_RS01375 ENOG4105BZU Histidine kinase E3166_RS01385 ENOG4105CS0 peptidase E3166_RS01395 ENOG4105CMB EAL domain-containing protein E3166_RS01400 ENOG41066T0 asmA family E3166_RS01405 ENOG4105CSH Transporter E3166_RS01410 ENOG4107H3J ribonuclease E3166_RS01415 ENOG4105CBN LysR family transcriptional regulator E3166_RS01420 ENOG4106S2D Transcriptional regulator E3166_RS01430 ENOG4105CA0 peroxidase E3166_RS01435 ENOG4105CVK Glutamate decarboxylase E3166_RS01440 ENOG4108NKV transcriptional regulator E3166_RS01450 ENOG4105BZS acriflavin resistance protein E3166_RS01455 ENOG4105C1P efflux transporter, rnd family, mfp subunit E3166_RS01465 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci E3166_RS01470 ENOG4108YK4 Acid-resistance membrane protein E3166_RS01475 ENOG41060V2 Acid-resistance protein E3166_RS01480 ENOG4105XXV Acid-resistance protein E3166_RS01485 ENOG4105KT7 mgtC SapB transporter E3166_RS01490 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) E3166_RS01495 ENOG4105EHG Permease protein E3166_RS01505 ENOG41090JE Utilization Protein E3166_RS01510 ENOG4105D4P Coproporphyrinogen iii oxidase E3166_RS01515 ENOG4107R4I Periplasmic binding protein E3166_RS01525 ENOG4107ENK receptor E3166_RS01530 ENOG4106QJH hemin transport protein E3166_RS01540 ENOG4105Y4Z Outer Membrane Lipoprotein E3166_RS01550 ENOG4105K89 arsenate reductase E3166_RS01555 ENOG4107R5R arsenical pump membrane protein E3166_RS01560 ENOG4105KBH arsR family transcriptional regulator E3166_RS01570 ENOG4105DC8 reductase E3166_RS01575 ENOG4105D6S protein involved in catabolism of external DNA E3166_RS01580 ENOG4105DGW oligopeptidase A E3166_RS01590 ENOG4105DUX Transporter E3166_RS01605 ENOG4105CJ3 phosphate transporter E3166_RS01610 ENOG4105CBX hi0933 family E3166_RS01620 ENOG4107UNS conserved inner membrane protein E3166_RS01635 ENOG4105D0S secretion protein (HlyD E3166_RS01640 ENOG4105CJ1 ABC, transporter E3166_RS01645 ENOG4105CMI transporter E3166_RS01660 ENOG4105D2N Aldolase E3166_RS01675 ENOG4105DT3 PTS system, galactitol-specific IIc component E3166_RS01680 ENOG41090UW PTS System E3166_RS01700 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E3166_RS01705 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E3166_RS01710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3166_RS01715 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3166_RS01720 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein E3166_RS01725 ENOG4107YAK holo-(acyl carrier protein) synthase 2 E3166_RS01730 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3166_RS01735 ENOG4105C2D reductase E3166_RS01745 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3166_RS01770 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) E3166_RS01800 ENOG4105E9Q Acyl-transferase E3166_RS01820 ENOG4105DSF transport protein E3166_RS01825 ENOG4105F9N Major Facilitator Superfamily E3166_RS01830 ENOG4108W1V Lipoprotein E3166_RS01835 ENOG4105EX9 Membrane E3166_RS01850 ENOG4107FS9 Membrane E3166_RS01860 ENOG4105MG3 Membrane E3166_RS01865 ENOG4106H78 methyltransferase E3166_RS01870 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E3166_RS01875 ENOG4105CAK Cell division ATP-binding protein ftsE E3166_RS01880 ENOG4105CRP Part of the ABC transporter FtsEX involved in E3166_RS01885 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3166_RS01890 ENOG4105CP9 extracellular ligand-binding receptor E3166_RS01905 ENOG4105U59 -acetyltransferase E3166_RS01910 ENOG4105CP9 extracellular ligand-binding receptor E3166_RS01915 ENOG4105C32 Amino acid ABC transporter (Permease) E3166_RS01920 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E3166_RS01925 ENOG4105C0Z ABC transporter E3166_RS01930 ENOG4108IV0 ABC, transporter E3166_RS01940 ENOG4105BZ7 extracellular solute-binding protein family 1 E3166_RS01945 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component E3166_RS01950 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component E3166_RS01955 ENOG4108IJ9 (ABC) transporter E3166_RS01960 ENOG4107T6V glycerophosphoryl diester phosphodiesterase E3166_RS01965 ENOG4105WC8 Conserved Protein E3166_RS01970 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E3166_RS01980 ENOG4105WCN acetyltransferase E3166_RS01985 ENOG4105D9R oxidoreductase E3166_RS01990 ENOG4105C2I pirin domain protein E3166_RS01995 ENOG4105DIQ Transcriptional regulator E3166_RS02000 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E3166_RS02005 ENOG4105C6Z Gluconate E3166_RS02010 ENOG4105C9U ATP-dependent DNA helicase RecQ E3166_RS02015 ENOG4105C9U ATP-dependent DNA helicase RecQ E3166_RS02030 ENOG41076UM multiple antibiotic resistance (MarC)-related protein E3166_RS02035 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E3166_RS02040 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E3166_RS02060 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E3166_RS02080 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E3166_RS02095 ENOG4105E98 transcriptional regulator DeoR family E3166_RS02100 ENOG4105CYB regulatoR E3166_RS02105 ENOG4105E0Y RtcB Protein E3166_RS02130 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E3166_RS02135 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) E3166_RS02140 ENOG4105C6Z Gluconate E3166_RS02150 ENOG4105MJ2 Competence protein E3166_RS02160 ENOG4105DNE Transposase E3166_RS02170 ENOG4105CE1 Ferrous iron transport protein b E3166_RS02175 ENOG4105XFK Ferrous iron transport protein A E3166_RS02180 ENOG4105BZM domain protein E3166_RS02185 ENOG4108RRZ Transcription elongation factor GreB E3166_RS02195 ENOG4105E0F Histidine kinase E3166_RS02205 ENOG4108MAJ Membrane E3166_RS02215 ENOG4105VEJ Heat shock protein E3166_RS02220 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E3166_RS02225 ENOG4105DQY intracellular growth attenuator E3166_RS02230 ENOG4107RK2 ADP-ribose diphosphatase NudE E3166_RS02235 ENOG4108JQC penicillin-binding protein 1A E3166_RS02240 ENOG4108U1Q Pilus assembly protein E3166_RS02245 ENOG41065NF Fimbrial assembly family protein E3166_RS02250 ENOG4105XPX DNA utilization protein HofO E3166_RS02255 ENOG4105ITY Required for the use of extracellular DNA as a nutrient E3166_RS02260 ENOG4105E4G Type IV pilus E3166_RS02275 ENOG4105EGB membrane protein DamX E3166_RS02280 ENOG4105DFE Dna adenine methylase E3166_RS02285 ENOG4105DJV ribulose-phosphate 3-epimerase E3166_RS02290 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E3166_RS02295 ENOG4105C31 Tryptophanyl-tRNA synthetase E3166_RS02300 ENOG4105FDP GntR family transcriptional regulator E3166_RS02310 ENOG4107Y0V Not clear, may be involved in an isomerization step E3166_RS02315 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E3166_RS02320 ENOG4107QHQ amino acid E3166_RS02325 ENOG4105VYH E3166_RS02335 ENOG4107V9H nitrite transporter E3166_RS02340 ENOG4105WZK nitrite reductase NADPH small subunit E3166_RS02345 ENOG4107QZF nitrite reductase NADPH large subunit E3166_RS02355 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E3166_RS02365 ENOG4105MZU cell filamentation protein E3166_RS02370 ENOG4105DDQ anthranilate synthase E3166_RS02375 ENOG4105C8Y Acetylornithine aminotransferase E3166_RS02380 ENOG410613R integral membrane protein, YccS YhfK family E3166_RS02390 ENOG4108UKZ OsmC family E3166_RS02395 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) E3166_RS02405 ENOG4105DNZ Alpha Beta Hydrolase E3166_RS02410 ENOG4105C5H ABC transporter E3166_RS02425 ENOG4105VKU nucleicacid-binding protein E3166_RS02430 ENOG4108YZY peptidylprolyl cis-trans isomerase E3166_RS02440 ENOG4108V1T peptidylprolyl cis-trans isomerase E3166_RS02445 ENOG4105WWK YheO domain protein E3166_RS02485 ENOG4105W53 bacterioferritin-associated ferredoxin E3166_RS02490 ENOG4108UQY Iron-storage protein E3166_RS02515 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) E3166_RS02560 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E3166_RS02605 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E3166_RS02610 ENOG41067V7 50S ribosomal protein L36 E3166_RS02640 ENOG4105VTS DnaJ-like, subfamily C E3166_RS02645 ENOG4105W1Y Transcriptional regulator E3166_RS02650 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system E3166_RS02660 ENOG4105C1A potassium transporter peripheral membrane E3166_RS02680 ENOG4105C79 DNA protecting protein DprA E3166_RS02690 ENOG4108WI1 Dna topoisomerase E3166_RS02695 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E3166_RS02705 ENOG4105SG3 Protein of unknown function (DUF1488) E3166_RS02710 ENOG4108Z0R Transferase E3166_RS02750 ENOG4105CDA abc transporter atp-binding protein E3166_RS02755 ENOG4105DRP amino acid AbC transporter E3166_RS02760 ENOG4105EZ7 amino acid ABC transporter E3166_RS02770 ENOG4105XCM membrane LIPOPROTEIN E3166_RS02780 ENOG4105C1P efflux transporter, rnd family, mfp subunit E3166_RS02785 ENOG4108XG4 DNA-binding transcriptional regulator E3166_RS02790 ENOG41061ME transport protein E3166_RS02795 ENOG4105CEC DNA methylase N-4 N-6 E3166_RS02805 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E3166_RS02815 ENOG4108IA2 Sodium pantothenate symporter E3166_RS02820 ENOG4105RG0 Membrane E3166_RS02825 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3166_RS02830 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E3166_RS02835 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family E3166_RS02840 ENOG41062P1 Diguanylate cyclase phosphodiesterase E3166_RS02850 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E3166_RS02855 ENOG4105VQ7 Rod shape-determining protein MreD E3166_RS02860 ENOG4108Z03 MAF-like protein E3166_RS02865 ENOG4105C03 ribonuclease E3166_RS02870 ENOG4105QD6 exported protein E3166_RS02875 ENOG4105D1U peptidase U62 modulator of DNA gyrase E3166_RS02880 ENOG4105CR8 Transcriptional regulator E3166_RS02885 ENOG4105ZQC membrane protein AaeX E3166_RS02900 ENOG4105UNR (Barnase) inhibitor E3166_RS02905 ENOG4105RID UPF0379 protein yhcN E3166_RS02920 ENOG4105C0H protease E3166_RS02925 ENOG4105C0H protease E3166_RS02930 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III E3166_RS02935 ENOG4105D6Z AFG1 family ATPase E3166_RS02950 ENOG4107MKT Stringent starvation protein a E3166_RS02955 ENOG4105KB2 stringent starvation protein b E3166_RS02960 ENOG4105CEE C4-dicarboxylate transporter E3166_RS02990 ENOG4108R66 Conserved Protein E3166_RS02995 ENOG4105DFS Conserved Protein E3166_RS03000 ENOG4105BZ8 glutamate synthase E3166_RS03005 ENOG4105CBC glutamate synthase E3166_RS03010 ENOG4105N5T Radical SAM Protein E3166_RS03015 ENOG4105BZU Histidine kinase E3166_RS03020 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain E3166_RS03030 ENOG4108NIH transferase activity, transferring phosphorus-containing groups E3166_RS03035 ENOG41080Z8 PHOSPHOCARRIER protein E3166_RS03045 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN E3166_RS03050 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA E3166_RS03055 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3166_RS03060 ENOG4108IUZ ABC transporter E3166_RS03065 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E3166_RS03070 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) E3166_RS03075 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E3166_RS03080 ENOG4105C2X Arabinose 5-phosphate isomerase E3166_RS03085 ENOG4105FEU K -dependent Na -Ca exchanger E3166_RS03090 ENOG4105DHJ ABC, transporter E3166_RS03095 ENOG4105CY3 ABC transporter, permease E3166_RS03100 ENOG4107PE3 Mammalian cell entry related domain protein E3166_RS03105 ENOG4105E3I toluene tolerance E3166_RS03110 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane E3166_RS03115 ENOG4105VFK BolA family E3166_RS03125 ENOG4105HVQ Regulatory factor of maltose metabolism E3166_RS03130 ENOG4105EAH synthase E3166_RS03145 ENOG4105QYV Membrane E3166_RS03155 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase E3166_RS03160 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E3166_RS03165 ENOG4105HBR Rna-binding protein E3166_RS03175 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E3166_RS03180 ENOG4105EEI dihydropteroate synthase E3166_RS03190 ENOG4105NTZ Preprotein translocase subunit SecG E3166_RS03200 ENOG4105DIJ Phosphoethanolamine transferase E3166_RS03220 ENOG4105CHV Transcription elongation factor NusA E3166_RS03260 ENOG4105C1J atp-dependent rna helicase E3166_RS03265 ENOG4105CIC tryptophan-specific transport protein E3166_RS03270 ENOG4105DEN Luciferase family E3166_RS03290 ENOG4108YYD acetyltransferase E3166_RS03300 ENOG4108ZPB UPF0306 protein E3166_RS03305 ENOG4107R7Y intracellular protease Pfpi family E3166_RS03310 ENOG4105K4T epimerase E3166_RS03315 ENOG4107S21 permease E3166_RS03320 ENOG4105W4M Transport-associated protein E3166_RS03340 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E3166_RS03360 ENOG4105CW0 outer membrane usher protein E3166_RS03365 ENOG4108VCD Chaperone E3166_RS03370 ENOG4105Q10 Fimbrial-like protein E3166_RS03380 ENOG4105F3R pts system mannose fructose sorbose family iid E3166_RS03390 ENOG4108UZY PTS System E3166_RS03400 ENOG4105E70 isomerase E3166_RS03405 ENOG4105CE4 GlcNAc 6-P deacetylase E3166_RS03410 ENOG4108YTN IIa component E3166_RS03415 ENOG4105F3R pts system mannose fructose sorbose family iid E3166_RS03425 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB E3166_RS03435 ENOG4105E98 transcriptional regulator DeoR family E3166_RS03440 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression E3166_RS03445 ENOG4105ZEG Suppressor protein E3166_RS03450 ENOG4105CTX dehydratase E3166_RS03455 ENOG4105DJB Major Facilitator Superfamily E3166_RS03465 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E3166_RS03470 ENOG4105BZW Glycerate kinase E3166_RS03495 ENOG410811B TRANSCRIPTIONal E3166_RS03500 ENOG4105C7B Threonine dehydratase E3166_RS03510 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E3166_RS03515 ENOG4105C6N Formate acetyltransferase E3166_RS03520 ENOG4105KME endoribonuclease L-psp E3166_RS03525 ENOG4105EJQ L-serine dehydratase E3166_RS03530 ENOG4105C44 Serine transporter E3166_RS03540 ENOG4106D80 Uncharacterized protein YhaL E3166_RS03545 ENOG4108CNN domain protein E3166_RS03550 ENOG4105CWB LysR family transcriptional Regulator E3166_RS03555 ENOG4105KAF membrAne E3166_RS03560 ENOG4105KAF membrAne E3166_RS03565 ENOG4105CHF Glutathione S-transferase E3166_RS03570 ENOG4108VBZ doxx family E3166_RS03575 ENOG4105YJD E3166_RS03580 ENOG41090KG Inner membrane protein YqjE E3166_RS03585 ENOG4105NE1 Conserved Protein E3166_RS03590 ENOG4105WAY exported protein E3166_RS03595 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) E3166_RS03600 ENOG4106W5V Membrane E3166_RS03605 ENOG4107YCY Transcriptional regulator E3166_RS03610 ENOG4105DPW Major facilitator superfamily MFS_1 E3166_RS03620 ENOG4105CTX dehydratase E3166_RS03625 ENOG4105P66 Membrane E3166_RS03630 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) E3166_RS03635 ENOG4105DU1 integral membrane protein, terc E3166_RS03640 ENOG4105EE0 oxidoreductase E3166_RS03645 ENOG4108UB4 uncharacterized protein ygjQ E3166_RS03650 ENOG4108VKG metal-dependent hydrolase E3166_RS03660 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase E3166_RS03665 ENOG4108Z3N Transcriptional regulator E3166_RS03670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E3166_RS03675 ENOG4107WCA isomerase E3166_RS03680 ENOG4107W6W Conserved Protein E3166_RS03685 ENOG4105E5D amino acid E3166_RS03690 ENOG4105FK9 beta-D-galactosidase beta subunit E3166_RS03695 ENOG4105CNT hydrolase family 2 E3166_RS03700 ENOG4105CQ4 Transcriptional regulator E3166_RS03705 ENOG4108Y51 tRNA-binding protein E3166_RS03715 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor E3166_RS03720 ENOG4105NTW Transcriptional regulator E3166_RS03725 ENOG4105Q26 Siderophore-interacting protein E3166_RS03740 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3166_RS03745 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E3166_RS03760 ENOG4107QPK )-transporter E3166_RS03765 ENOG4107GFK fumarate E3166_RS03770 ENOG4106DSS Tartrate dehydratase subunit alpha E3166_RS03775 ENOG4105EJC lysr family transcriptional regulator E3166_RS03785 ENOG4107ZVW dihydroneopterin aldolase E3166_RS03800 ENOG4106MWK domain protein E3166_RS03805 ENOG4105I7R Adenylate cyclase E3166_RS03830 ENOG4107S78 Band 7 protein E3166_RS03835 ENOG4105PV3 Inner membrane protein yqiJ E3166_RS03845 ENOG4105W0Z cytoplasmic protein E3166_RS03865 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E3166_RS03870 ENOG4106032 Glutathionylspermidine synthase E3166_RS03880 ENOG4105DFG type I secretion outer membrane protein E3166_RS03885 ENOG41087AY ADP-Ribose pyrophosphatase E3166_RS03890 ENOG4108SX3 cytoplasmic protein E3166_RS03895 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E3166_RS03900 ENOG4105IPS esterase E3166_RS03905 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3166_RS03915 ENOG4105E0A ABC, transporter E3166_RS03920 ENOG4105DQ5 transport system permease protein E3166_RS03925 ENOG4105EHG Permease protein E3166_RS03935 ENOG4106KNT transcriptional regulator E3166_RS03940 ENOG4105VRH Antibiotic biosynthesis monooxygenase E3166_RS03945 ENOG4105NF4 modulator of drug activity E3166_RS03950 ENOG4105DHQ Histidine kinase E3166_RS03955 ENOG4105XJC Two component transcriptional regulator (Winged helix family E3166_RS03960 ENOG4105H4F exported protein E3166_RS03965 ENOG4105F4I Transcriptional regulator E3166_RS03970 ENOG4108J59 Extracellular solute-binding protein, family 5 E3166_RS03975 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3166_RS03980 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E3166_RS03985 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E3166_RS03990 ENOG4105CCT upf0313 protein E3166_RS04005 ENOG4105CV8 reductase E3166_RS04010 ENOG4108I6A alcohol dehydrogenase E3166_RS04015 ENOG4105CF7 AraC family transcriptional regulator E3166_RS04020 ENOG4108K81 inner membrane protein YghB E3166_RS04025 ENOG4105C28 cystathionine E3166_RS04030 ENOG4105CWK Biopolymer transport protein, ExbB E3166_RS04035 ENOG4108ZZF transport protein (ExbD) E3166_RS04040 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E3166_RS04050 ENOG4105CPC Aldo Keto reductase E3166_RS04060 ENOG410900S Protein of unknown function (DUF2623) E3166_RS04065 ENOG4105E3S small subunit E3166_RS04070 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E3166_RS04075 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit E3166_RS04080 ENOG4105DPX Hydrogenase, large subunit E3166_RS04085 ENOG4108USZ hydrogenase E3166_RS04090 ENOG4108WGS hydrogenase 2-specific chaperone E3166_RS04095 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E3166_RS04100 ENOG41082MF Hydrogenase assembly chaperone hypC hupF E3166_RS04105 ENOG4105CYM Glutathione S-transferase E3166_RS04110 ENOG4106032 Glutathionylspermidine synthase E3166_RS04135 ENOG4108YXQ IS66 Orf2 family protein E3166_RS04140 ENOG4105E5H Transposase E3166_RS04145 ENOG4108YXQ IS66 Orf2 family protein E3166_RS04195 ENOG4105H38 Membrane E3166_RS04210 ENOG4108YXQ IS66 Orf2 family protein E3166_RS04235 ENOG4108UQV Membrane E3166_RS04240 ENOG4105CXN decarboxylase E3166_RS04245 ENOG4105EAA nucleoside E3166_RS04260 ENOG4105CEN a g-specific adenine glycosylase E3166_RS04270 ENOG41090ED Protein with unknown function (DUF469) E3166_RS04275 ENOG4105K33 Periplasmic Protein E3166_RS04280 ENOG4105HDK L-asparaginase E3166_RS04285 ENOG4106MH3 alpha helix chain E3166_RS04290 ENOG4105CSA Coproporphyrinogen iii oxidase E3166_RS04295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E3166_RS04305 ENOG4108VIA integral membrane protein E3166_RS04310 ENOG4105DFA alanine racemase domain protein E3166_RS04315 ENOG4105CZX twitching motility protein E3166_RS04330 ENOG4105D7Z glutathione synthase E3166_RS04335 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E3166_RS04340 ENOG4105RWS endonuclease I E3166_RS04345 ENOG4105GPY SprT protein E3166_RS04350 ENOG4107QNK )-transporter E3166_RS04370 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) E3166_RS04385 ENOG4108K0D peptidase, M48 E3166_RS04390 ENOG4105CV1 Transketolase (EC 2.2.1.1) E3166_RS04395 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia E3166_RS04400 ENOG4105CTS PTS system mannitol-specific E3166_RS04405 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein E3166_RS04410 ENOG4108Q8A Fructose-1,6-bisphosphatase E3166_RS04415 ENOG4108R4K DNA-binding, transcriptional regulator E3166_RS04420 ENOG4107Z1W Fructose transport system kinase E3166_RS04425 ENOG4108JJB ABC transporter E3166_RS04430 ENOG4108JJB ABC transporter E3166_RS04455 ENOG4105BZA Phosphoglycerate kinase E3166_RS04460 ENOG4105D2N Aldolase E3166_RS04465 ENOG4105D64 Mechanosensitive ion channel E3166_RS04470 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E3166_RS04475 ENOG4105MPN Membrane E3166_RS04485 ENOG4105CYC Transferase E3166_RS04490 ENOG4108M7F enoyl-CoA hydratase isomerase E3166_RS04495 ENOG4105DJT lAO AO transport system ATPase E3166_RS04500 ENOG4105D5P Methylmalonyl-coA mutase E3166_RS04515 ENOG4108JQ1 Dehydrogenase E3166_RS04530 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E3166_RS04550 ENOG4107RAQ aminopeptidase E3166_RS04555 ENOG4105D0A hydroxylase E3166_RS04560 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E3166_RS04585 ENOG4105CS2 ec 3.2.1.21 E3166_RS04590 ENOG4105N5Z UPF0267 protein E3166_RS04595 ENOG4108UT2 hemolysin iii E3166_RS04605 ENOG4105Y75 tpr repeat protein E3166_RS04610 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB E3166_RS04615 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) E3166_RS04620 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3166_RS04625 ENOG4105T95 Thiol disulfide interChange protein E3166_RS04630 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E3166_RS04640 ENOG4105CRK lysyL-tRNA synthetase E3166_RS04660 ENOG4105C2W permease E3166_RS04665 ENOG4105BZ8 glutamate synthase E3166_RS04675 ENOG4105C7N Xanthine uracil vitamin C permease E3166_RS04680 ENOG4107QUY Guanine deaminase E3166_RS04685 ENOG4105C2W permease E3166_RS04690 ENOG4105C7W Xanthine dehydrogenase E3166_RS04695 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase E3166_RS04705 ENOG4105BZ8 glutamate synthase E3166_RS04710 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase E3166_RS04715 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC E3166_RS04720 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family E3166_RS04725 ENOG4105C5B carbamate kinase E3166_RS04735 ENOG4107S4Y M20 DapE family protein YgeY E3166_RS04740 ENOG4107RCH Diaminopropionate ammonia-lyase E3166_RS04745 ENOG4105IW6 Carbamoyltransferase E3166_RS04750 ENOG4108JUB Transcriptional regulator E3166_RS04755 ENOG4108UTP (2Fe-2S)-binding domain protein E3166_RS04760 ENOG4108HR6 Dehydrogenase E3166_RS04765 ENOG4105C7W Xanthine dehydrogenase E3166_RS04770 ENOG4108K5P (LipO)protein E3166_RS04790 ENOG41090HZ type iii secretion E3166_RS04800 ENOG4108N8R Invasion protein E3166_RS04805 ENOG4108HR8 type iii secretion E3166_RS04810 ENOG4108JIR Flagellum-specific ATP synthase E3166_RS04825 ENOG4105T85 surface presentation of antigens protein E3166_RS04830 ENOG41075IY surface presentation of antigens protein SpaP E3166_RS04835 ENOG4105U07 type iii secretion E3166_RS04845 ENOG4108M6W surface presentation of antigens protein SpaS E3166_RS04865 ENOG4105Y7Q type iii secretion E3166_RS04870 ENOG4106BTR E3166_RS04875 ENOG4108RBT type iii secretion E3166_RS04900 ENOG4105K5T PilT protein E3166_RS04910 ENOG4108YAB Invasion protein E3166_RS04935 ENOG4105FV3 E3166_RS04940 ENOG4108TC1 Transcriptional regulator E3166_RS04945 ENOG4105ISV protein with bipartite regulator domain E3166_RS04950 ENOG4108MHD transport protein E3166_RS04955 ENOG4105CHU acetyl-coa acetyltransferase E3166_RS04965 ENOG4105CHR reductase E3166_RS04970 ENOG4107QNK )-transporter E3166_RS04980 ENOG4105RQF LysR family Transcriptional regulator E3166_RS04990 ENOG41060NJ transcriptional regulator E3166_RS05005 ENOG4105CPC Aldo Keto reductase E3166_RS05010 ENOG4105SUV lipoprotein YgdR E3166_RS05015 ENOG4105EE5 Membrane protein terC E3166_RS05030 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E3166_RS05045 ENOG4105IPU prepilin peptidase dependent protein A E3166_RS05050 ENOG4105JCS prepilin peptidase dependent protein E3166_RS05055 ENOG4105SEN Protein of unknown function (DUF2509) E3166_RS05060 ENOG4105RVB Prepilin peptidase dependent protein c E3166_RS05065 ENOG4105DSY exodeoxyribonuclease V, gamma E3166_RS05070 ENOG4107QXK peptidase E3166_RS05075 ENOG4107QKA exodeoxyribonuclease V beta E3166_RS05080 ENOG4107QYX exodeoxyribonuclease v alpha E3166_RS05085 ENOG4108EKC n-acetylglutamate synthase E3166_RS05090 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E3166_RS05110 ENOG4105CA3 membrane-bound lytic murein transglycosylase E3166_RS05115 ENOG4105CUZ uba thif-type nad fad binding protein E3166_RS05120 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E3166_RS05125 ENOG4105C9B Cysteine desulfurase E3166_RS05130 ENOG4105M5B (LipO)protein E3166_RS05135 ENOG4105ETT transcriptional Regulator, LysR family E3166_RS05140 ENOG4105M08 Membrane E3166_RS05150 ENOG4107EDW L-fucose operon activator E3166_RS05160 ENOG4105CMG Carbohydrate kinase E3166_RS05170 ENOG4105EDR glucose galactose transporter E3166_RS05175 ENOG4107W7X Aldolase E3166_RS05180 ENOG4105C0A alcohol dehydrogenase E3166_RS05190 ENOG4105EJQ L-serine dehydratase E3166_RS05195 ENOG4105C44 Serine transporter E3166_RS05200 ENOG4105EWT decarboxylase family E3166_RS05215 ENOG4105WP7 tRNA pseudouridine synthase C E3166_RS05220 ENOG4105DR9 pseudouridine synthase E3166_RS05225 ENOG4105QDK Flavodoxin E3166_RS05230 ENOG4105DJB Major Facilitator Superfamily E3166_RS05240 ENOG4105EQX glucarate dehydratase E3166_RS05245 ENOG4105BZU Histidine kinase E3166_RS05250 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E3166_RS05255 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E3166_RS05260 ENOG4106A2Z transcriptional regulator antitoxin, MazE E3166_RS05265 ENOG4105MZG transcriptional modulator of maze toxin, mazf E3166_RS05270 ENOG4105DXN mazG family E3166_RS05285 ENOG4105HA9 of methanol dehydrogenase type E3166_RS05295 ENOG4105HA9 of methanol dehydrogenase type E3166_RS05305 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E3166_RS05310 ENOG4108CWB sugar kinase ygcE E3166_RS05315 ENOG4108ITV Inner membrane protein yqcE E3166_RS05320 ENOG4105CHR reductase E3166_RS05335 ENOG4106IKH Electron transfer flavoprotein E3166_RS05345 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator E3166_RS05350 ENOG4105WQV ferredoxin-like protein E3166_RS05360 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase E3166_RS05365 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E3166_RS05380 ENOG4105CYR Crispr-associated protein, cse1 family E3166_RS05390 ENOG41060M0 Crispr-associated protein, cse4 family E3166_RS05395 ENOG4108VWQ crispr-associated protein E3166_RS05405 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E3166_RS05410 ENOG4105PWE CRISPR-associated protein cas2 E3166_RS05415 ENOG4108MXK alkaline phosphatase isozyme conversion E3166_RS05435 ENOG4105N0Z inner membrane protein ygbE E3166_RS05470 ENOG4108K5P (LipO)protein E3166_RS05475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3166_RS05480 ENOG4105PX9 Transcriptional regulator, MarR family E3166_RS05485 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E3166_RS05490 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E3166_RS05495 ENOG4105KZM cytoplasmic protein E3166_RS05500 ENOG4105MEW serine threonine protein phosphatase E3166_RS05515 ENOG4105VXR cytoplasmic protein E3166_RS05520 ENOG4108JUA Transcriptional regulator E3166_RS05525 ENOG4105C45 hydrogenase expression formation protein (HypE) E3166_RS05530 ENOG4105CQS hydrogenase expression formation protein HypD E3166_RS05535 ENOG41083WG hydrogenase assembly chaperone E3166_RS05540 ENOG4107RSS Hydrogenase accessory protein HypB E3166_RS05545 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E3166_RS05550 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA E3166_RS05555 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E3166_RS05560 ENOG4107R30 NADH dehydrogenase E3166_RS05565 ENOG4107TDF Formate hydrogenlyase subunit 4 E3166_RS05570 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E3166_RS05575 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit E3166_RS05580 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E3166_RS05585 ENOG4105I6X formate hydrogenlyase maturation E3166_RS05590 ENOG4108MG9 hydrogenase 3 maturation protease E3166_RS05595 ENOG4105CS2 ec 3.2.1.21 E3166_RS05600 ENOG4105C5Y PTS System E3166_RS05605 ENOG4105DDV Transcriptional regulator (LacI family E3166_RS05610 ENOG4108RC0 Electron transport protein E3166_RS05615 ENOG4105C8H hydrogenase maturation protein Hypf E3166_RS05635 ENOG4105C2X Arabinose 5-phosphate isomerase E3166_RS05640 ENOG410804X Transcriptional regulator E3166_RS05645 ENOG4105J92 DNA-binding transcriptional activator GutM E3166_RS05650 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase E3166_RS05655 ENOG4105VI0 Pts system, glucitol sorbitol-specific E3166_RS05665 ENOG410787A Pts system, glucitol sorbitol-specific E3166_RS05670 ENOG4105CVE Lytic murein transglycosylase E3166_RS05675 ENOG4107TH8 cina domain protein E3166_RS05690 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E3166_RS05695 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) E3166_RS05725 ENOG4107VXZ Hydrolase E3166_RS05730 ENOG4105W39 Membrane E3166_RS05745 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3166_RS05750 ENOG4105CW7 secretion protein, HlyD family E3166_RS05755 ENOG4105NTK Transcriptional repressor Mpra E3166_RS05760 ENOG4105ZED uncharacterized protein ygaH E3166_RS05765 ENOG4108UMN azlc family E3166_RS05770 ENOG4105EQ0 Major Facilitator superfamily E3166_RS05775 ENOG4105GIJ Glycine betaine E3166_RS05780 ENOG4108HQS Glycine betaine E3166_RS05785 ENOG4108IJ7 Glycine betaine E3166_RS05790 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3166_RS05795 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3166_RS05805 ENOG4105WAZ (Glutaredoxin-like protein) NrdH E3166_RS05810 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E3166_RS05820 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) E3166_RS05825 ENOG4108WMJ Protein of unknown function (DUF2002) E3166_RS05830 ENOG4108RNS Exports L-alanine (By similarity) E3166_RS05835 ENOG4108X73 DNA- binding protein E3166_RS05840 ENOG4108V62 Rhodanese domain protein E3166_RS05845 ENOG41080HT Transcriptional regulator, arsr family E3166_RS05850 ENOG4105VPI YqaE family transport protein E3166_RS05855 ENOG4109066 lysm domain bon superfamily protein E3166_RS05860 ENOG4108PVQ transcriptional regulator E3166_RS05865 ENOG4105C85 amino acid E3166_RS05870 ENOG4108JPW Aminotransferase E3166_RS05875 ENOG4105C26 Dehydrogenase E3166_RS05880 ENOG4105D5U fad dependent oxidoreductase E3166_RS05915 ENOG4108MGN ATP-binding component of a transport system E3166_RS06005 ENOG4106FE3 DNA repair E3166_RS06020 ENOG4108Z1B Cyclase dehydrase E3166_RS06030 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E3166_RS06035 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E3166_RS06050 ENOG4108JU6 CBS domain protein E3166_RS06055 ENOG4106KVJ cytochrome C assembly protein E3166_RS06060 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E3166_RS06085 ENOG41090EK ompa motb domain protein E3166_RS06090 ENOG4108KHX Diguanylate cyclase E3166_RS06095 ENOG4108WS1 E3166_RS06100 ENOG4105QP9 Protein of unknown function (DUF2799) E3166_RS06105 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E3166_RS06110 ENOG4105EHE chorismate mutase- prephenate dehydrogenase E3166_RS06115 ENOG4105CQC Prephenate dehydratase E3166_RS06125 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA E3166_RS06130 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E3166_RS06135 ENOG4105C34 Pseudouridine synthase E3166_RS06140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E3166_RS06145 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E3166_RS06170 ENOG4105CSH Transporter E3166_RS06175 ENOG4105T42 (LipO)protein E3166_RS06180 ENOG4105JIM Phosphatidylserine synthase E3166_RS06185 ENOG4105CD5 CoA-binding domain protein E3166_RS06190 ENOG4106IUH DTW domain containing protein E3166_RS06195 ENOG4105K63 Thioredoxin E3166_RS06200 ENOG4105EIB trna rrna methyltransferase E3166_RS06215 ENOG4108VP3 Lysine exporter protein (LysE YggA) E3166_RS06220 ENOG41090KR LysR family transcriptional Regulator E3166_RS06225 ENOG4105C1J atp-dependent rna helicase E3166_RS06230 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) E3166_RS06235 ENOG4108IYU L-aspartate oxidase E3166_RS06245 ENOG4105EMN RNA polymerase sigma factor E3166_RS06250 ENOG41069PW sigma-e factor negative regulatory protein E3166_RS06255 ENOG4105VQK sigma E regulatory protein, MucB RseB E3166_RS06260 ENOG4105WMJ Positive regulator of sigma E, RseC MucC E3166_RS06270 ENOG4105C3F Signal peptidase i E3166_RS06290 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E3166_RS06305 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E3166_RS06310 ENOG4106G6Q Transcriptional regulator E3166_RS06315 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB E3166_RS06320 ENOG4108Z6B deaminase E3166_RS06325 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E3166_RS06330 ENOG4108ETH Formylglycinamide ribotide synthetase E3166_RS06335 ENOG4107WP9 Histidine kinase E3166_RS06340 ENOG4108SKK alpha helix protein E3166_RS06345 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E3166_RS06355 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E3166_RS06365 ENOG4108NZE NAGC-like transcriptional regulator E3166_RS06370 ENOG4107HQ7 repeat protein E3166_RS06375 ENOG4105FCA ABC transporter periplasmic-binding protein YphF E3166_RS06380 ENOG4108F37 ATP-binding component of a transport system E3166_RS06385 ENOG4105CNN ABC, transporter E3166_RS06390 ENOG4105CPQ Dehydrogenase E3166_RS06395 ENOG4105CPQ Dehydrogenase E3166_RS06400 ENOG4108ZKT aldose 1-epimerase E3166_RS06405 ENOG4108SB3 DoxX Family E3166_RS06430 ENOG4105FUY alpha subunit E3166_RS06435 ENOG4108W5M transcriptional regulator E3166_RS06440 ENOG4105D8G Major Facilitator superfamily E3166_RS06445 ENOG4108MN2 Stationary phase inducible protein CsiE E3166_RS06450 ENOG4107XM9 (LipO)protein E3166_RS06455 ENOG4105ECY inositol monophosphatase E3166_RS06475 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E3166_RS06495 ENOG4108ZIT Ferredoxin, 2FE-2S E3166_RS06500 ENOG4105WVQ Fe-S assembly protein IscX E3166_RS06510 ENOG4105YYA enhanced serine sensitivity protein SseB E3166_RS06515 ENOG4105KHC sulfurtransferase E3166_RS06520 ENOG4105DN3 alpha-2-macroglobulin domain protein E3166_RS06525 ENOG4108JQB penicillin-binding protein 1C E3166_RS06530 ENOG4107QY8 reductase E3166_RS06535 ENOG4105QAX Iron-sulfur E3166_RS06540 ENOG4107KGK dmso reductase anchor subunit E3166_RS06575 ENOG4105N21 Membrane E3166_RS06590 ENOG4105VPD cellular component movement E3166_RS06600 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E3166_RS06610 ENOG41066DY Membrane E3166_RS06615 ENOG4108ZMA Outer membrane lipoprotein E3166_RS06620 ENOG41062G3 Protein of unknown function (DUF2633) E3166_RS06630 ENOG4105BZU Histidine kinase E3166_RS06635 ENOG4105C9X ppx gppa phosphatase E3166_RS06640 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) E3166_RS06645 ENOG4108V3E phosphoribosylglycinamide formyltransferase E3166_RS06660 ENOG4105C2W permease E3166_RS06665 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) E3166_RS06670 ENOG4105K89 arsenate reductase E3166_RS06675 ENOG4105ERG peptidase m48, ste24p E3166_RS06680 ENOG4105C02 permease E3166_RS06685 ENOG4105TMB Formate nitrite transporter E3166_RS06690 ENOG4108JUA Transcriptional regulator E3166_RS06695 ENOG4105I6X formate hydrogenlyase maturation E3166_RS06700 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E3166_RS06710 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E3166_RS06715 ENOG4108JPZ Monovalent cation H antiporter subunit D E3166_RS06720 ENOG4107WQX hydrogenase 4 membrane subunit E3166_RS06725 ENOG4105D65 subunit l E3166_RS06730 ENOG4107TDF Formate hydrogenlyase subunit 4 E3166_RS06735 ENOG4108JPZ Monovalent cation H antiporter subunit D E3166_RS06740 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E3166_RS06745 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E3166_RS06750 ENOG4105RH4 Glycine cleavage system transcriptional repressor E3166_RS06760 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E3166_RS06770 ENOG4105CGZ zinc metallopeptidase E3166_RS06780 ENOG4106KED esterase YpfH E3166_RS06795 ENOG4105KUZ arsenate reductase E3166_RS06805 ENOG4105BZS acriflavin resistance protein E3166_RS06810 ENOG4105BZU Histidine kinase E3166_RS06815 ENOG4105BZ8 glutamate synthase E3166_RS06825 ENOG4108PVD exported protein E3166_RS06830 ENOG4105CV1 Transketolase (EC 2.2.1.1) E3166_RS06835 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3166_RS06840 ENOG4105C6K Malic enzyme E3166_RS06845 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place E3166_RS06850 ENOG4106S4J ethanolamine utilization protein EutP E3166_RS06855 ENOG4105NDK ethanolamine utilization protein E3166_RS06860 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase E3166_RS06865 ENOG4107WUY phosphate acetyltransferase E3166_RS06870 ENOG4105KNY Microcompartments protein E3166_RS06875 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E3166_RS06880 ENOG4108EKI Dehydrogenase E3166_RS06885 ENOG4107RWI ethanolamine utilization protein eutJ E3166_RS06890 ENOG4105C0A alcohol dehydrogenase E3166_RS06895 ENOG4105ENY Ethanolamine utilization protein eutH E3166_RS06900 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase E3166_RS06905 ENOG4105CPD ethanolamine ammonia-lyase E3166_RS06915 ENOG4106D67 ethanolamine utilization protein E3166_RS06920 ENOG4108X49 Ethanolamine utilization protein EutK E3166_RS06925 ENOG4108K3Z AraC family transcriptional regulator E3166_RS06935 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E3166_RS06945 ENOG4105QZU Inner membrane protein YfeZ E3166_RS06950 ENOG4105E7K (LipO)protein E3166_RS06955 ENOG4105EZR dyp-type peroxidase family protein E3166_RS06960 ENOG4107QK9 Beta-lactamase E3166_RS06965 ENOG4105C5Y PTS System E3166_RS06980 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr E3166_RS06985 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein E3166_RS06990 ENOG4108I5D sulfate abc transporter E3166_RS06995 ENOG4105ECW sulfate abc transporter E3166_RS07000 ENOG4108IJ6 ABC transporter E3166_RS07005 ENOG4105C6T cysteine synthase E3166_RS07020 ENOG4105C5Y PTS System E3166_RS07025 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E3166_RS07035 ENOG4105C6T cysteine synthase E3166_RS07055 ENOG4105VRT cytoplasmic protein E3166_RS07060 ENOG4105DHU Bile acid E3166_RS07065 ENOG4108M0I Transcriptional regulator E3166_RS07105 ENOG4105D7V transposase E3166_RS07110 ENOG4105GXM Putative transcription regulator (DUF1323) E3166_RS07115 ENOG4105HZG regulatoR E3166_RS07130 ENOG4108KMM Diguanylate cyclase E3166_RS07135 ENOG4105D9N nucleoside E3166_RS07145 ENOG4109076 Conserved Protein E3166_RS07150 ENOG4105VCT ion-transport protein YfeO E3166_RS07160 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E3166_RS07165 ENOG410863U PTS System E3166_RS07170 ENOG4105DC7 peptidase M24 E3166_RS07175 ENOG4105CN9 Peptidase m42 family protein E3166_RS07180 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E3166_RS07185 ENOG4108CIP transcriptional regulator E3166_RS07190 ENOG4105DY9 regulatoR E3166_RS07195 ENOG4108HRK Histidine kinase E3166_RS07200 ENOG4105CHM Aminotransferase E3166_RS07210 ENOG4105D1S lipid A biosynthesis E3166_RS07215 ENOG4105W9M Membrane E3166_RS07225 ENOG4108V08 YfdX protein E3166_RS07235 ENOG4105CFN oxalyl-CoA decarboxylase E3166_RS07240 ENOG4108N2Y auxin Efflux E3166_RS07245 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F E3166_RS07250 ENOG4105BZU Histidine kinase E3166_RS07255 ENOG4108WQH regulatoR E3166_RS07260 ENOG4105CW7 secretion protein, HlyD family E3166_RS07265 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3166_RS07280 ENOG4106NDP Transcriptional regulator E3166_RS07285 ENOG4108HKT sucrose-6-phosphate hydrolase E3166_RS07305 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E3166_RS07355 ENOG4105DFP Integrase E3166_RS07365 ENOG4105S64 Formate nitrite transporter E3166_RS07370 ENOG410903C (LipO)protein E3166_RS07380 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation E3166_RS07385 ENOG4105KZW UPF0381 protein E3166_RS07400 ENOG4108BY2 phosphohistidine phosphatase E3166_RS07410 ENOG4106PG1 outer membrane usher protein E3166_RS07415 ENOG4108FZ9 Chaperone E3166_RS07420 ENOG4105NEV Fimbrial E3166_RS07425 ENOG4105UGQ Fimbrial E3166_RS07430 ENOG4105US4 fimbrial-like protein yfcP E3166_RS07450 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase E3166_RS07460 ENOG4105EJ9 Membrane E3166_RS07465 ENOG4108BPE -transporting atpase E3166_RS07470 ENOG4105MH2 YfcL protein E3166_RS07475 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E3166_RS07480 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3166_RS07485 ENOG4105F9N Major Facilitator Superfamily E3166_RS07490 ENOG4106WZ1 flagella biosynthesis regulator E3166_RS07500 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E3166_RS07510 ENOG4105DQR SNARE associated Golgi E3166_RS07520 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E3166_RS07525 ENOG4108S3P Sporulation domain protein E3166_RS07530 ENOG4105E96 Colicin v production protein E3166_RS07535 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E3166_RS07540 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E3166_RS07545 ENOG4105E89 ABC transporter E3166_RS07550 ENOG4105E89 ABC transporter E3166_RS07555 ENOG4105DSP amino acid AbC transporter E3166_RS07560 ENOG4106YG3 ABC transporter E3166_RS07565 ENOG4108JEH abc transporter atp-binding protein E3166_RS07570 ENOG4105DNE Transposase E3166_RS07575 ENOG4105ECP epimerase E3166_RS07580 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase E3166_RS07585 ENOG4105CYM Glutathione S-transferase E3166_RS07590 ENOG4108SHQ Glutathione S-transferase E3166_RS07595 ENOG4108RE9 Phosphodiesterase E3166_RS07600 ENOG4105PTV Nudix Hydrolase E3166_RS07605 ENOG4105CSX c4-dicarboxylate anaerobic carrier E3166_RS07610 ENOG4105C6K Malic enzyme E3166_RS07615 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E3166_RS07625 ENOG4105XWI UPF0304 protein E3166_RS07630 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 E3166_RS07635 ENOG4107QWE )-transporter E3166_RS07645 ENOG4105CHM Aminotransferase E3166_RS07650 ENOG4107NQ8 LysR family Transcriptional regulator E3166_RS07670 ENOG4105GKE subunit e E3166_RS07675 ENOG4107QIZ NADH dehydrogenase E3166_RS07680 ENOG4108IEH NADH dehydrogenase subunit g E3166_RS07695 ENOG4107UFS subunit j E3166_RS07705 ENOG4105D65 subunit l E3166_RS07710 ENOG4105C8S subunit m E3166_RS07720 ENOG4105GDX Domain of unknown function (DUF1877) E3166_RS07735 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is E3166_RS07740 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) E3166_RS07745 ENOG4107YB6 acetyltransferase, (GNAT) family E3166_RS07750 ENOG4105TNS Conserved Protein E3166_RS07755 ENOG4105E4F Isochorismate synthase E3166_RS07770 ENOG4108IPT Naphthoate synthase E3166_RS07780 ENOG4105CEY Amp-dependent synthetase and ligase E3166_RS07785 ENOG4106GZG polymyxin resistance protein B E3166_RS07825 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) E3166_RS07835 ENOG4108UII YfaZ family E3166_RS07840 ENOG4108EWA cinA-like protein E3166_RS07845 ENOG4107258 Transcriptional regulator E3166_RS07850 ENOG4105CXK mandelate racemase muconate lactonizing E3166_RS07855 ENOG4105CSP Major Facilitator Superfamily E3166_RS07870 ENOG4105CNV Aldolase E3166_RS07875 ENOG4105DNE Transposase E3166_RS07880 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E3166_RS07890 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A E3166_RS07895 ENOG4105CXY transporter E3166_RS07900 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E3166_RS07910 ENOG4105GZI Transcriptional regulator E3166_RS07915 ENOG4105CZM Major Facilitator E3166_RS07920 ENOG4105FQR PH-inducible protein involved in stress response E3166_RS07925 ENOG4105XPH Ferredoxin E3166_RS07930 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3166_RS07935 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3166_RS07940 ENOG4107GHC outer membrane autotransporter E3166_RS07950 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3166_RS07955 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) E3166_RS07960 ENOG4108QJJ Protein of unknown function (DUF1175) E3166_RS07965 ENOG4107S52 alpha-2-macroglobulin domain protein E3166_RS07970 ENOG41081SK signal peptide protein E3166_RS07975 ENOG41081SK signal peptide protein E3166_RS07980 ENOG4105EDV vault protein E3166_RS07985 ENOG4105BZU Histidine kinase E3166_RS07990 ENOG41068CG regulatoR E3166_RS07995 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC E3166_RS08000 ENOG4105FCK Membrane E3166_RS08005 ENOG4105CJ2 (LipO)protein E3166_RS08010 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E3166_RS08015 ENOG4105CF1 Alkylated DNA repair protein E3166_RS08020 ENOG4105IBP Cyclic peptide transporter E3166_RS08035 ENOG4108ZNS ferredoxin-type protein NapF E3166_RS08040 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase E3166_RS08050 ENOG4108BGM Quinol dehydrogenase periplasmic component E3166_RS08055 ENOG4105GXZ Ferredoxin-type protein NapH E3166_RS08060 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) E3166_RS08065 ENOG4105CUW cytochrome C-TYPE protein E3166_RS08070 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E3166_RS08075 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E3166_RS08080 ENOG41060IM Heme exporter protein E3166_RS08085 ENOG4105X3C heme exporter protein E3166_RS08095 ENOG4105DA4 cytochrome c-type biogenesis protein E3166_RS08100 ENOG4107QX9 Thiol disulfide interChange protein E3166_RS08105 ENOG4105KWW Biogenesis protein E3166_RS08110 ENOG4105WH1 Two component transcriptional regulator luxr family E3166_RS08115 ENOG4108MGN ATP-binding component of a transport system E3166_RS08125 ENOG4105E68 Sulfatase E3166_RS08145 ENOG4105CFI type iii restriction protein res subunit E3166_RS08150 ENOG4105I08 Pseudouridine synthase E3166_RS08155 ENOG4105C2C drug resistance transporter, Bcr CflA E3166_RS08160 ENOG4105HG6 E3166_RS08165 ENOG4108JQ5 ABC transporter E3166_RS08170 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E3166_RS08175 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E3166_RS08180 ENOG4105E43 Extracellular solute-binding protein, family 5 E3166_RS08185 ENOG4105CXC rtn protein E3166_RS08190 ENOG4107TT5 NLP P60 protein E3166_RS08195 ENOG41076MN Phosphoesterase, PA-phosphatase related E3166_RS08200 ENOG4105CKI cobalamin synthesis protein E3166_RS08205 ENOG4105DEI Mannitol dehydrogenase E3166_RS08215 ENOG4105KRS Proteinase inhibitor E3166_RS08220 ENOG4105S8Q sugar efflux transporter E3166_RS08225 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E3166_RS08230 ENOG4105DE4 1-phosphofructokinase E3166_RS08235 ENOG4105DM4 PTS System E3166_RS08240 ENOG4105DD7 kinase (PfkB family E3166_RS08245 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) E3166_RS08250 ENOG4105D9N nucleoside E3166_RS08255 ENOG4108Y4K DNA-binding transcriptional activator E3166_RS08265 ENOG4105D9N nucleoside E3166_RS08270 ENOG4105DD7 kinase (PfkB family E3166_RS08275 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) E3166_RS08280 ENOG4105HMI Membrane E3166_RS08285 ENOG4105DUM transcriptional regulator, lysR family E3166_RS08290 ENOG4108IQI permease E3166_RS08295 ENOG4105D05 Receptor E3166_RS08300 ENOG4105C4W S-formylglutathione hydrolase E3166_RS08310 ENOG4105DHF Membrane E3166_RS08315 ENOG41060NJ transcriptional regulator E3166_RS08320 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator E3166_RS08325 ENOG4105C2J ABC transporter E3166_RS08330 ENOG4108HWV )-transporter E3166_RS08335 ENOG4107SJI Dehydrogenase E3166_RS08340 ENOG4105BZ8 glutamate synthase E3166_RS08345 ENOG4105Y9N Membrane E3166_RS08350 ENOG4107GZ4 SanA protein E3166_RS08360 ENOG41067MG lrgb family E3166_RS08390 ENOG4108RXX maleylacetoacetate isomerase E3166_RS08395 ENOG4105MSY salicylate hydroxylase E3166_RS08400 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E3166_RS08415 ENOG4105H9W Short-chain dehydrogenase reductase Sdr E3166_RS08420 ENOG4105KHU inner membrane protein YohD E3166_RS08425 ENOG41069YE inner membrane protein yohC E3166_RS08430 ENOG41061WM D-Alanyl-D-Alanine E3166_RS08435 ENOG4105CXG d-lactate dehydrogenase E3166_RS08440 ENOG4107QK4 glycoside hydrolase, family 3 domain protein E3166_RS08445 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E3166_RS08450 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component E3166_RS08455 ENOG4108IJ8 ABC transporter E3166_RS08460 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component E3166_RS08470 ENOG4108XDN Transcriptional regulator E3166_RS08495 ENOG4107TII Recombinase E3166_RS08500 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi E3166_RS08505 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 E3166_RS08510 ENOG4105RWQ Protein of unknown function (DUF1364) E3166_RS08525 ENOG4105HRS Antitermination protein E3166_RS08565 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS08615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E3166_RS08690 ENOG4108X9F tail fiber protein E3166_RS08710 ENOG4106FE3 DNA repair E3166_RS08715 ENOG4108HRK Histidine kinase E3166_RS08720 ENOG4108NEV two component transcriptional regulator, LytTR family E3166_RS08725 ENOG4108W15 Protein of unknown function (DUF1456) E3166_RS08730 ENOG4108YCW (LipO)protein E3166_RS08735 ENOG410903U zinc ion binding E3166_RS08740 ENOG4105DEG Vwa containing coxe family protein E3166_RS08745 ENOG4105RD5 E3166_RS08750 ENOG4105RD5 E3166_RS08755 ENOG4105KKX ATPase associated with various cellular activities aaa_5 E3166_RS08765 ENOG4108KDT Molybdate metabolism regulator E3166_RS08785 ENOG4105D1F ATP-binding protein E3166_RS08790 ENOG41067AK Protein of unknown function (DUF2574) E3166_RS08795 ENOG41063W2 Fimbrial protein E3166_RS08800 ENOG4108MQF Chaperone E3166_RS08805 ENOG4105CW0 outer membrane usher protein E3166_RS08825 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly E3166_RS08830 ENOG41061MD high-affinity nickel-transporter E3166_RS08860 ENOG4105DWF phosphomethylpyrimidine kinase E3166_RS08865 ENOG4108UQ1 hydrolase, family 25 E3166_RS08870 ENOG4105FDP GntR family transcriptional regulator E3166_RS08875 ENOG4108TFM Kinase, PfkB family E3166_RS08880 ENOG4108KD5 ADP-ribosylation crystallin J1 E3166_RS08885 ENOG4105EAA nucleoside E3166_RS08890 ENOG4105EIE fructose-bisphosphate aldolase E3166_RS08905 ENOG41082GB PTS system galactitol-specific transporter subunit IIA E3166_RS08910 ENOG41090UW PTS System E3166_RS08915 ENOG4105DT3 PTS system, galactitol-specific IIc component E3166_RS08920 ENOG4107WTH Galactitol-1-phosphate dehydrogenase E3166_RS08935 ENOG41076Z6 Uncharacterized protein yegR E3166_RS08940 ENOG4105CFP Peptidase U32 E3166_RS08945 ENOG4105KWI UPF0339 protein E3166_RS08950 ENOG4105E3W Two component transcriptional regulator (Winged helix family E3166_RS08955 ENOG4105EB3 Histidine kinase E3166_RS08970 ENOG4105BZS acriflavin resistance protein E3166_RS08995 ENOG4108M24 von Willebrand factor, type A E3166_RS09000 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase E3166_RS09005 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding E3166_RS09010 ENOG4105R8A Heat shock protein E3166_RS09015 ENOG4105D03 DNA-3-methyladenine glycosylase II E3166_RS09025 ENOG4105DBI uridine monophosphokinase E3166_RS09035 ENOG4108GAE asmA family E3166_RS09050 ENOG4105EE5 Membrane protein terC E3166_RS09060 ENOG4105DAY polysaccharide export protein E3166_RS09065 ENOG4105KJF protein tyrosine phosphatase E3166_RS09070 ENOG4105D75 Capsular exopolysaccharide family E3166_RS09075 ENOG41090RK glycosyl transferase E3166_RS09080 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB E3166_RS09085 ENOG4107RXY Glycosyl transferase E3166_RS09090 ENOG4108NYJ Colanic acid E3166_RS09095 ENOG4105ECJ Glycosyl Transferase E3166_RS09100 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF E3166_RS09105 ENOG4105C0K Gdp-mannose 4,6-dehydratase E3166_RS09110 ENOG4105C30 Nad-dependent epimerase dehydratase E3166_RS09115 ENOG4105FGF GDP-mannose mannosyl hydrolase E3166_RS09120 ENOG4106CD9 glycosyl transferase group 1 E3166_RS09125 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E3166_RS09130 ENOG4107QKV phosphomannomutase E3166_RS09135 ENOG4105D3Q Sugar transferase E3166_RS09140 ENOG4105PSV Polysaccharide Biosynthesis Protein E3166_RS09145 ENOG4105C74 pyruvyl transferase E3166_RS09150 ENOG4107T8Q Glycosyl transferase (Group 1 E3166_RS09155 ENOG4105G1A colanic acid biosynthesis protein E3166_RS09160 ENOG4105DMT epimerase dehydratase E3166_RS09165 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E3166_RS09170 ENOG4105JEU Glycosyl transferase, family 2 E3166_RS09190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E3166_RS09200 ENOG4105C0K Gdp-mannose 4,6-dehydratase E3166_RS09205 ENOG4105C30 Nad-dependent epimerase dehydratase E3166_RS09210 ENOG4105FGF GDP-mannose mannosyl hydrolase E3166_RS09215 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E3166_RS09220 ENOG4107QKV phosphomannomutase E3166_RS09225 ENOG4107WZ3 Transferase E3166_RS09230 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E3166_RS09235 ENOG4105C6Y Udp-glucose 6-dehydrogenase E3166_RS09260 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E3166_RS09265 ENOG4105ECC imidazole-glycerol-phosphate dehydratase E3166_RS09275 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E3166_RS09290 ENOG4107SRH Nad-dependent epimerase dehydratase E3166_RS09295 ENOG4105EQ1 Transcriptional regulator E3166_RS09305 ENOG4105CUB amino acid E3166_RS09310 ENOG4105CUC YeeE YedE family protein E3166_RS09320 ENOG4105CJB Exodeoxyribonuclease I E3166_RS09325 ENOG4105DFP Integrase E3166_RS09425 ENOG4105CDU Replicative dna helicase E3166_RS09475 ENOG4108R1E Serine threonine protein phosphatase 1 E3166_RS09525 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS09530 ENOG4105KUS lysozyme E3166_RS09535 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E3166_RS09550 ENOG4106YSC E3166_RS09635 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) E3166_RS09665 ENOG4108YXQ IS66 Orf2 family protein E3166_RS09670 ENOG4105E5H Transposase E3166_RS09685 ENOG4108X9F tail fiber protein E3166_RS09695 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E3166_RS09705 ENOG4105DZ1 carboxypeptidase E3166_RS09715 ENOG4105DR8 Membrane E3166_RS09750 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles E3166_RS09760 ENOG4108YGG dna repair protein E3166_RS09765 ENOG4105MFG Antirestriction protein E3166_RS09770 ENOG4106H6R UPF0380 protein E3166_RS09790 ENOG4108YIV E3166_RS09810 ENOG4105E5H Transposase E3166_RS09815 ENOG4108YXQ IS66 Orf2 family protein E3166_RS09825 ENOG4108YZT Adenosylcobinamide kinase E3166_RS09840 ENOG4108PXI ErfK YbiS YcfS YnhG E3166_RS09850 ENOG4106P55 Transcriptional regulator E3166_RS09855 ENOG4107R11 Transcriptional regulator E3166_RS09865 ENOG4105UQX Mate efflux family protein E3166_RS09875 ENOG4105CDY transcriptional regulatory protein E3166_RS09880 ENOG4105FYV Amp nucleosidase E3166_RS09885 ENOG4105CSH Transporter E3166_RS09915 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) E3166_RS09940 ENOG4106G8A Qin prophage E3166_RS10025 ENOG4108MXB Protein of unknown function (DUF968) E3166_RS10030 ENOG4105KSK (crossover) junction endodeoxyribonuclease E3166_RS10075 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS10110 ENOG4106YSC E3166_RS10145 ENOG4105IM0 capsid protein E3166_RS10200 ENOG4108X9F tail fiber protein E3166_RS10220 ENOG4108VKM cytochrome b561 E3166_RS10225 ENOG4108MEK Metal-binding protein YodA E3166_RS10240 ENOG4105VT2 5-hydroxyisourate hydrolase E3166_RS10245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3166_RS10250 ENOG4107ZY3 Histidine kinase E3166_RS10270 ENOG4105EST Metal Dependent Phosphohydrolase E3166_RS10275 ENOG4105DVF Cytosine-specific methyltransferase E3166_RS10280 ENOG41090BB DNA mismatch endonuclease (vsr) E3166_RS10285 ENOG4105FDR Membrane E3166_RS10290 ENOG4105CKW Inner membrane protein yedI E3166_RS10295 ENOG4105VNZ cytoplasmic protein E3166_RS10300 ENOG4105BZU Histidine kinase E3166_RS10310 ENOG4105YX3 cellular response to acidity E3166_RS10320 ENOG4107TKS colanic acid capsular biosynthesis activation protein A E3166_RS10325 ENOG4105D19 Role in flagellar biosynthesis (By similarity) E3166_RS10335 ENOG4105CN7 Flagellar biosynthetic protein FliP E3166_RS10340 ENOG4105K0P flagellar biosynthesis protein E3166_RS10345 ENOG4105DD5 Flagellar motor switch protein E3166_RS10350 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E3166_RS10355 ENOG4107ZI8 flagellar basal body-associated protein flil E3166_RS10360 ENOG4105WF4 Flagellar hook-length control protein E3166_RS10365 ENOG4105GSA Flagellar export protein flij E3166_RS10370 ENOG4108JIR Flagellum-specific ATP synthase E3166_RS10375 ENOG41090PJ Flagellar assembly protein E3166_RS10380 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E3166_RS10385 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) E3166_RS10390 ENOG4105VQ0 flagellar hook-basal body complex protein fliE E3166_RS10400 ENOG4108HF7 Gcn5-related n-acetyltransferase E3166_RS10410 ENOG4108HF7 Gcn5-related n-acetyltransferase E3166_RS10415 ENOG4108RAV Conserved protein E3166_RS10425 ENOG41066VF YeeE YedE family protein E3166_RS10430 ENOG4108W9D (LipO)protein E3166_RS10435 ENOG4105E5K Alpha-amylase E3166_RS10440 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) E3166_RS10445 ENOG4105MQ3 flagellar protein FliS E3166_RS10450 ENOG4105DTS flagellar hook-associated E3166_RS10455 ENOG4105I03 Flagellin E3166_RS10460 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3166_RS10465 ENOG4108M9K flagella biosynthesis protein FliZ E3166_RS10470 ENOG4105EAB amino acid AbC transporter E3166_RS10480 ENOG4105E5Q amino acid AbC transporter E3166_RS10485 ENOG4105CDA abc transporter atp-binding protein E3166_RS10490 ENOG4105VJY transcriptional regulator E3166_RS10495 ENOG4105XVG cytoplasmic protein E3166_RS10505 ENOG4105WH1 Two component transcriptional regulator luxr family E3166_RS10580 ENOG4105UZW Tail fiber assembly protein E3166_RS10680 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3166_RS10685 ENOG4106RHG Yeca family E3166_RS10690 ENOG4105E0U tyrosine-specific transport protein E3166_RS10695 ENOG4105VVZ metal-binding protein E3166_RS10700 ENOG41090A1 ferritin E3166_RS10705 ENOG4105P23 (LipO)protein E3166_RS10715 ENOG4105N4N Protein of unknown function (DUF2766) E3166_RS10720 ENOG4108UEC Ferritin-like protein E3166_RS10725 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator E3166_RS10730 ENOG4105C2J ABC transporter E3166_RS10735 ENOG4105CNN ABC, transporter E3166_RS10740 ENOG4108K4C ec 3.1.3.12 E3166_RS10750 ENOG4108VA4 Universal stress protein E3166_RS10760 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region E3166_RS10765 ENOG4107RD7 Flagellar Motor Protein, MotA E3166_RS10770 ENOG4105ER2 Ompa motb domain protein E3166_RS10775 ENOG4105CBS Chea signal transduction histidine kinase E3166_RS10780 ENOG4108V3W Chemotaxis protein, CheW E3166_RS10785 ENOG4105C8Q Methyl-accepting chemotaxis E3166_RS10790 ENOG4105C8Q Methyl-accepting chemotaxis E3166_RS10795 ENOG4105BZU Histidine kinase E3166_RS10800 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) E3166_RS10805 ENOG4108VYJ response regulator receiver protein E3166_RS10815 ENOG4105D00 flagellar biosynthetic protein flhB E3166_RS10820 ENOG4105D7B Flagellar biosynthesis protein flha E3166_RS10825 ENOG4105W13 flagellar protein E3166_RS10840 ENOG4106ZCM YecM protein E3166_RS10850 ENOG4105CUW cytochrome C-TYPE protein E3166_RS10855 ENOG4108J2R molybdopterin oxidoreductase E3166_RS10870 ENOG4105WJG Glutathione E3166_RS10875 ENOG41081XQ Conserved Protein E3166_RS10880 ENOG4105D3W isochorismatase E3166_RS10890 ENOG4108TIT dATP pyrophosphohydrolase E3166_RS10895 ENOG4105CDY transcriptional regulatory protein E3166_RS10905 ENOG4107S01 Repressor protein MetJ E3166_RS10925 ENOG4105FAV ABC, transporter E3166_RS10935 ENOG4105NXV High-affinity zinc uptake system protein E3166_RS10940 ENOG4105DR5 peptidase E3166_RS10945 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E3166_RS10950 ENOG4105CA9 Pyruvate kinase E3166_RS10955 ENOG4106KNT transcriptional regulator E3166_RS10960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E3166_RS10965 ENOG4105C01 Dihydroxy-acid dehydratase E3166_RS10970 ENOG4108UHU Aldolase E3166_RS10975 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR E3166_RS10980 ENOG4105X2V dna damage-inducible protein E3166_RS10990 ENOG4108Q2J Inner membrane protein YebE E3166_RS10995 ENOG4105CUG Oligopeptidase b E3166_RS11000 ENOG4105UMD exodeoxyribonuclease X E3166_RS11005 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E3166_RS11010 ENOG4105MPK DNA polymerase III subunit theta E3166_RS11015 ENOG4105FXM Copper resistance protein E3166_RS11020 ENOG4108PNC copper resistance E3166_RS11025 ENOG4105NKT exported protein E3166_RS11030 ENOG4108R1E Serine threonine protein phosphatase 1 E3166_RS11035 ENOG4105UVW uncharacterized protein yebW E3166_RS11040 ENOG4105WT8 Protein of unknown function (DUF1480) E3166_RS11050 ENOG4105DY2 Paraquat-inducible protein b E3166_RS11055 ENOG4105H2K paraquat-inducible protein a E3166_RS11060 ENOG4108ZGC gaf domain protein E3166_RS11070 ENOG4105CN1 protease E3166_RS11080 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3166_RS11085 ENOG4105J4Q Transcriptional regulator E3166_RS11090 ENOG4105TIK E3166_RS11100 ENOG4105Q3Y exported protein E3166_RS11115 ENOG4105DHI Methyltransferase E3166_RS11130 ENOG4105F3R pts system mannose fructose sorbose family iid E3166_RS11135 ENOG4105ETZ PTS System E3166_RS11140 ENOG4105DAS pts system E3166_RS11145 ENOG4105EE5 Membrane protein terC E3166_RS11150 ENOG4107XTP (EAL) domain protein E3166_RS11155 ENOG4105EJQ L-serine dehydratase E3166_RS11165 ENOG4105CRQ synthase (Component I) E3166_RS11175 ENOG4105V2F Uncharacterized protein yoac E3166_RS11180 ENOG4105M4H endoribonuclease L-psp E3166_RS11185 ENOG4105DVT helicase E3166_RS11190 ENOG41072GX Peptidase M22 Glycoprotease E3166_RS11195 ENOG4105Y4Z Outer Membrane Lipoprotein E3166_RS11200 ENOG4105CEY Amp-dependent synthetase and ligase E3166_RS11205 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) E3166_RS11210 ENOG4105E3J oxidoreductase E3166_RS11215 ENOG4105DVW rieske (2Fe-2S) E3166_RS11220 ENOG4105C94 Transporter E3166_RS11225 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E3166_RS11230 ENOG4105EJC lysr family transcriptional regulator E3166_RS11235 ENOG4108NIW Leucine export protein LeuE E3166_RS11240 ENOG4108YS1 cytoplasmic protein E3166_RS11245 ENOG4105YP6 Domain of unknown function (DUF1869) E3166_RS11250 ENOG4105Y3U Transglycosylase-associated protein E3166_RS11260 ENOG4106G4W E3166_RS11265 ENOG410620I Diguanylate cyclase E3166_RS11270 ENOG4105UCG Domain of unknown function (DUF333) E3166_RS11275 ENOG4105K78 MarR family Transcriptional regulator E3166_RS11280 ENOG4105DJ2 Major Facilitator Superfamily E3166_RS11285 ENOG4105R1U AraC Family Transcriptional Regulator E3166_RS11300 ENOG4108KXH Ybak prolyl-tRNA synthetase associated E3166_RS11305 ENOG4108KHP Diguanylate cyclase E3166_RS11310 ENOG4106KTS Inner membrane protein yeaI E3166_RS11320 ENOG4105CYN Serine protein kinase E3166_RS11325 ENOG4105GNX MltA-interacting MipA family protein E3166_RS11330 ENOG4105CV8 reductase E3166_RS11335 ENOG4105DSB aldose 1-epimerase E3166_RS11340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E3166_RS11350 ENOG4105VUT cytoplasmic protein E3166_RS11355 ENOG4105CPQ Dehydrogenase E3166_RS11360 ENOG4107TE1 transport protein E3166_RS11365 ENOG4105CPQ Dehydrogenase E3166_RS11370 ENOG4105D2N Aldolase E3166_RS11375 ENOG4107UH8 sugar kinase E3166_RS11380 ENOG4105CPC Aldo Keto reductase E3166_RS11385 ENOG4105E98 transcriptional regulator DeoR family E3166_RS11400 ENOG4108RWI nicotinamidase E3166_RS11405 ENOG4105HDK L-asparaginase E3166_RS11415 ENOG4105D07 Signal peptide peptidase, SppA E3166_RS11420 ENOG41069NU Nitroreductase E3166_RS11425 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E3166_RS11430 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E3166_RS11435 ENOG41065FB inner membrane protein ynji E3166_RS11440 ENOG4105D82 Glutamate dehydrogenase E3166_RS11445 ENOG4105MTM Protein of unknown function (DUF1496) E3166_RS11450 ENOG4105M6F mutator MutT protein E3166_RS11455 ENOG4108T9J Cdp-alcohol phosphatidyltransferase E3166_RS11460 ENOG4107RM6 sulfurtransferase E3166_RS11465 ENOG4108VGW abc transporter atp-binding protein E3166_RS11470 ENOG4105CXZ ABC transporter, permease E3166_RS11475 ENOG4105VNH ABC transporter solute-binding protein E3166_RS11480 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E3166_RS11485 ENOG4108N5C SNARE associated Golgi protein-related protein E3166_RS11490 ENOG4108KCW iron-sulfur cluster binding E3166_RS11495 ENOG4108RSN SNARE associated Golgi E3166_RS11500 ENOG4105CGK Exodeoxyribonuclease III E3166_RS11530 ENOG4108SPG Periplasmic Protein E3166_RS11540 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) E3166_RS11550 ENOG4105KKI DNA-binding transcriptional activator OsmE E3166_RS11555 ENOG4105VZJ PTS System E3166_RS11560 ENOG4105CK1 PTS System E3166_RS11565 ENOG4105VCP PTS System E3166_RS11570 ENOG4105EZV Transcriptional regulator E3166_RS11575 ENOG4105F8D glycoside hydrolase family 4 E3166_RS11585 ENOG4105CH6 catalase E3166_RS11600 ENOG4108ETY sodium dicarboxylate symporter E3166_RS11605 ENOG4107K5X Membrane-bound metal-dependent hydrolase E3166_RS11610 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E3166_RS11615 ENOG4107PN8 YfeABCD locus regulator E3166_RS11625 ENOG4105P10 Uncharacterized protein ydiZ E3166_RS11630 ENOG4105DE4 1-phosphofructokinase E3166_RS11635 ENOG4108NE3 Salt-induced outer membrane protein E3166_RS11655 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E3166_RS11660 ENOG41082NX 50s ribosomal protein l35 E3166_RS11680 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E3166_RS11695 ENOG4108V06 Glutathione peroxidase E3166_RS11705 ENOG4108QBX (LipO)protein E3166_RS11710 ENOG4108TC0 Diguanylate phosphodiesterase E3166_RS11725 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E3166_RS11735 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E3166_RS11740 ENOG4105CEY Amp-dependent synthetase and ligase E3166_RS11745 ENOG41090P5 ferredoxin-like protein E3166_RS11750 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E3166_RS11755 ENOG4105C10 Electron transfer flavoprotein E3166_RS11760 ENOG4105CV7 Electron transfer flavoprotein E3166_RS11765 ENOG4105W4W Transcriptional regulator E3166_RS11770 ENOG4105C1G acyl-Coa dehydrogenase E3166_RS11775 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E3166_RS11790 ENOG4105EMV Major Facilitator E3166_RS11795 ENOG4105EMV Major Facilitator E3166_RS11800 ENOG4105SUA Ydil protein E3166_RS11810 ENOG4105IPI Membrane E3166_RS11815 ENOG4105CQB FAD linked oxidase domain protein E3166_RS11820 ENOG4105KA0 thioesterase Superfamily protein E3166_RS11825 ENOG410671Z uncharacterized protein ydiH E3166_RS11830 ENOG4108Z4V iron-sulfur cluster assembly E3166_RS11835 ENOG4105DIW FeS assembly protein SUFB E3166_RS11840 ENOG4105C3K feS assembly ATPase SufC E3166_RS11845 ENOG4105JRK feS assembly protein SufD E3166_RS11860 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E3166_RS11865 ENOG4105KMX major outer membrane lipoprotein E3166_RS11870 ENOG4105CA9 Pyruvate kinase E3166_RS11875 ENOG4105RFR Protein of unknown function (DUF2767) E3166_RS11880 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein E3166_RS11885 ENOG4105WE2 aldehyde ferredoxin oxidoreductase E3166_RS11890 ENOG4105JVW E3166_RS11895 ENOG4108393 oxidoreductase Fe-S subunit E3166_RS11900 ENOG4108NWD Cytochrome E3166_RS11905 ENOG4108Y7C Conserved Protein E3166_RS11910 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain E3166_RS11915 ENOG4105N0V mono-oxygenase ydhR E3166_RS11940 ENOG4108R6K riboflavin synthase, subunit alpha E3166_RS11945 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E3166_RS11950 ENOG4105CZQ inner membrane transport protein YdhC E3166_RS11955 ENOG4105F52 Transcriptional regulator E3166_RS11970 ENOG4105F27 Major Facilitator E3166_RS11975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E3166_RS11980 ENOG4105K4H Nlp p60 protein E3166_RS11985 ENOG4105M2J Glutaredoxin E3166_RS11990 ENOG4107QRT dEAD DEAH box helicase E3166_RS12000 ENOG4108UYE Lactoylglutathione lyase E3166_RS12005 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E3166_RS12010 ENOG4108WUH Transcriptional regulator, TetR family E3166_RS12015 ENOG4105XZD Fe-S protein E3166_RS12025 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E3166_RS12035 ENOG4105Y49 secretion protein, HlyD family E3166_RS12050 ENOG4108XTF Outer Membrane Lipoprotein E3166_RS12060 ENOG410642K Lysozyme inhibitor E3166_RS12075 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) E3166_RS12080 ENOG4108K3A Glutathione S-transferase E3166_RS12085 ENOG4105DUX Transporter E3166_RS12090 ENOG4105CSM endonuclease III E3166_RS12100 ENOG4108UQQ Electron transport complex E3166_RS12125 ENOG4105M9B inner membrane protein ydgK E3166_RS12130 ENOG4105QZ5 OriC-binding nucleoid-associated protein E3166_RS12135 ENOG4106C6R beta-lactam resistance protein E3166_RS12140 ENOG4105D9R oxidoreductase E3166_RS12150 ENOG4105C87 Aminotransferase class I and II E3166_RS12155 ENOG4105CI1 PTS System E3166_RS12160 ENOG4107P2S Transcriptional regulator E3166_RS12165 ENOG4107ZQV short-chain dehydrogenase reductase E3166_RS12170 ENOG4105XEA Tetr family transcriptional regulator E3166_RS12180 ENOG4105CT4 transporter E3166_RS12190 ENOG4106J39 exported protein E3166_RS12195 ENOG4105EIP mannose-6-phosphate isomerase E3166_RS12200 ENOG4107GFK fumarate E3166_RS12205 ENOG4105C9Q fumarate hydratase class II E3166_RS12210 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) E3166_RS12215 ENOG4105JJR Histidine kinase E3166_RS12220 ENOG4107EXC regulatoR E3166_RS12225 ENOG4105RA2 Membrane E3166_RS12235 ENOG4105D5Q Arginine ornithine antiporter E3166_RS12240 ENOG4105C5D exported protein E3166_RS12245 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E3166_RS12250 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E3166_RS12255 ENOG4105DSF transport protein E3166_RS12270 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap E3166_RS12285 ENOG4105D94 Major Facilitator Superfamily E3166_RS12290 ENOG4106NZI LysR family Transcriptional regulator E3166_RS12295 ENOG4105DAG ROK family E3166_RS12300 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E3166_RS12310 ENOG4108NEM leader-binding protein dmsD E3166_RS12315 ENOG4107KGK dmso reductase anchor subunit E3166_RS12320 ENOG4105QAX Iron-sulfur E3166_RS12325 ENOG4105C3J Cysteine desulfurase E3166_RS12330 ENOG4107QY8 reductase E3166_RS12335 ENOG4105KBG Protein of unknown function (DUF1161) E3166_RS12340 ENOG4105D69 UPF0257 lipoprotein ynfC E3166_RS12345 ENOG4108MK9 spermidine N(1)-acetyltransferase E3166_RS12375 ENOG4106G8A Qin prophage E3166_RS12430 ENOG4105JBR DNA replication protein E3166_RS12455 ENOG4105WI6 cell killing protein encoded within cryptic prophage E3166_RS12465 ENOG4108MXB Protein of unknown function (DUF968) E3166_RS12470 ENOG4105KSK (crossover) junction endodeoxyribonuclease E3166_RS12510 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS12550 ENOG4106YSC E3166_RS12660 ENOG4108X9F tail fiber protein E3166_RS12680 ENOG4105E5H Transposase E3166_RS12685 ENOG4108YXQ IS66 Orf2 family protein E3166_RS12710 ENOG41076J9 exonuclease VIII E3166_RS12715 ENOG4106G8A Qin prophage E3166_RS12795 ENOG4105WI6 cell killing protein encoded within cryptic prophage E3166_RS12800 ENOG4105H4F exported protein E3166_RS12810 ENOG4108MXB Protein of unknown function (DUF968) E3166_RS12815 ENOG4105KSK (crossover) junction endodeoxyribonuclease E3166_RS12860 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS12900 ENOG4106YSC E3166_RS12995 ENOG4108X9F tail fiber protein E3166_RS13030 ENOG4106N4H Non-LEE-encoded type III effector F E3166_RS13040 ENOG4105E5H Transposase E3166_RS13045 ENOG4108YXQ IS66 Orf2 family protein E3166_RS13095 ENOG4108N8X transition metal ion binding E3166_RS13100 ENOG4108Z9Z response to DNA damage stimulus E3166_RS13120 ENOG4105DK0 Indole-3-glycerol phosphate synthase E3166_RS13125 ENOG4108EFP Anthranilate synthase component II E3166_RS13130 ENOG4105CRQ synthase (Component I) E3166_RS13140 ENOG4105DB7 PHP domain protein E3166_RS13145 ENOG4107RTD sua5 ycio yrdc ywlc family protein E3166_RS13165 ENOG4105FE9 pseudouridine synthase E3166_RS13170 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E3166_RS13175 ENOG4105UBK short-chain dehydrogenase reductase E3166_RS13180 ENOG4105ERU peptidase E3166_RS13185 ENOG4105RKX Protein of unknown function (DUF2498) E3166_RS13190 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E3166_RS13195 ENOG4107R11 Transcriptional regulator E3166_RS13215 ENOG4107QM5 aconitate hydratase E3166_RS13225 ENOG4105EYK Phosphatidylglycerophosphatase B E3166_RS13230 ENOG4105Q4A inner membrane protein yciS E3166_RS13235 ENOG4105CFV Tetratricopeptide repeat protein E3166_RS13245 ENOG4108ZJT translation initiation factor, Sui1 E3166_RS13255 ENOG4105N2W Transcriptional regulator E3166_RS13265 ENOG4105BZU Histidine kinase E3166_RS13275 ENOG4105Q4T oxidoreductase E3166_RS13280 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E3166_RS13285 ENOG41067SE Tetr family transcriptional regulator E3166_RS13305 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E3166_RS13310 ENOG4105C2C drug resistance transporter, Bcr CflA E3166_RS13315 ENOG4108JQ2 peptide transport system atp-binding protein E3166_RS13320 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein E3166_RS13325 ENOG4108EU3 peptide transport system, permease E3166_RS13330 ENOG4108I5W peptide transport system, permease protein E3166_RS13335 ENOG4108HIY periplasmic E3166_RS13340 ENOG4105N0E Protein of unknown function (DUF2543) E3166_RS13345 ENOG4105CUB amino acid E3166_RS13355 ENOG4105CFQ glutamine synthetase E3166_RS13360 ENOG4108Z86 Glutamine amidotransferase E3166_RS13365 ENOG4107VRI Transcriptional regulator E3166_RS13370 ENOG4105C26 Dehydrogenase E3166_RS13375 ENOG4105CJP fad dependent oxidoreductase E3166_RS13380 ENOG4108JPW Aminotransferase E3166_RS13385 ENOG4105E51 psp operon transcriptional activator E3166_RS13390 ENOG41087YS Phage shock protein A E3166_RS13395 ENOG4105YYT phage shock protein B E3166_RS13400 ENOG4105FM1 phage shock protein C E3166_RS13405 ENOG4105NNG Peripheral inner membrane phage-shock protein E3166_RS13410 ENOG4105K8Z Phage shock protein E3166_RS13425 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component E3166_RS13430 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component E3166_RS13435 ENOG4107RRD Dehydrogenase E3166_RS13440 ENOG4107TYA transient receptor potential locus E3166_RS13445 ENOG4105CK5 oxidoreductase E3166_RS13450 ENOG4105C71 hydrolase family 65, central catalytic E3166_RS13455 ENOG4107URF beta-phospho-glucomutase E3166_RS13460 ENOG4108IJ9 (ABC) transporter E3166_RS13465 ENOG4107EFV Outer membrane protein G E3166_RS13470 ENOG4105FKQ transcriptional regulator E3166_RS13475 ENOG4105CM6 amino acid regulated cytosolic protein E3166_RS13485 ENOG4108JU8 Transcriptional regulator E3166_RS13490 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E3166_RS13495 ENOG4107S8C mandelate racemase muconate lactonizing E3166_RS13500 ENOG4105KXI murein peptide amidase A E3166_RS13515 ENOG4105ENX hydrolase E3166_RS13520 ENOG4105EQ2 LysR family Transcriptional regulator E3166_RS13525 ENOG4107QSI ABC, transporter E3166_RS13530 ENOG4105D64 Mechanosensitive ion channel E3166_RS13535 ENOG4105S5I Membrane E3166_RS13540 ENOG4105Q9Y Universal stress protein E3166_RS13545 ENOG4105DS0 Transcriptional regulator, Crp Fnr family E3166_RS13550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E3166_RS13555 ENOG4105CFC Transporter E3166_RS13560 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B E3166_RS13565 ENOG4105CH2 amidohydrolase E3166_RS13570 ENOG4106KR7 LysR family Transcriptional regulator E3166_RS13575 ENOG4108DG9 Smr protein MutS2 E3166_RS13580 ENOG4105BZU Histidine kinase E3166_RS13595 ENOG4105C1J atp-dependent rna helicase E3166_RS13605 ENOG4108RW8 Universal stress protein F E3166_RS13615 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) E3166_RS13620 ENOG4105IKK cytoplasmic protein E3166_RS13625 ENOG41090X5 Heat shock protein hslJ E3166_RS13630 ENOG4105C5I Dehydrogenase E3166_RS13635 ENOG4107H52 Dicarboxylate transport E3166_RS13640 ENOG410689M (LipO)protein E3166_RS13645 ENOG4105WXT Conserved Protein E3166_RS13655 ENOG4107EF2 surface-exposed virulence protein E3166_RS13660 ENOG4107S5I aldo keto reductase E3166_RS13670 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase E3166_RS13675 ENOG4108HPI phosphatidate Cytidylyltransferase E3166_RS13685 ENOG41077RS Phosphatase E3166_RS13690 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E3166_RS13695 ENOG4105CQ7 ATP-dependent helicase E3166_RS13720 ENOG4107DB1 DUF218 domain E3166_RS13725 ENOG4105C26 Dehydrogenase E3166_RS13730 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E3166_RS13735 ENOG4105CPW cytochrome b561 E3166_RS13740 ENOG4105UPP uncharacterized protein ydcA E3166_RS13745 ENOG4107NK6 Hok/gef family E3166_RS13750 ENOG4105C8Q Methyl-accepting chemotaxis E3166_RS13755 ENOG4105DDW LysR family Transcriptional regulator E3166_RS13760 ENOG4105E32 cytoplasmic protein E3166_RS13770 ENOG4105Z2P Protein of unknown function (DUF465) E3166_RS13780 ENOG4107WE3 acetyltransferase YdcK E3166_RS13785 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein E3166_RS13790 ENOG41088CC tellurite resistance protein tehB E3166_RS13795 ENOG4108KKZ (LipO)protein E3166_RS13800 ENOG4105DKK Benzoate E3166_RS13805 ENOG4108JCI Transcriptional regulator E3166_RS13810 ENOG4105CFP Peptidase U32 E3166_RS13815 ENOG4105RR0 Protein of unknown function (DUF2554) E3166_RS13825 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin E3166_RS13830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E3166_RS13835 ENOG4107TYH extracellular solute-binding protein family 1 E3166_RS13840 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E3166_RS13845 ENOG4105D81 ABC transporter, permease E3166_RS13850 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component E3166_RS13865 ENOG410654E Membrane E3166_RS13870 ENOG4105R71 cytoplasmic protein E3166_RS13875 ENOG4108T9Y Inner membrane protein ydcZ E3166_RS13880 ENOG4108Z7F N-acetyltransferase E3166_RS13885 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E3166_RS13890 ENOG4108WYP Transcriptional regulator E3166_RS13895 ENOG4105CHB tonB-dependent Receptor E3166_RS13900 ENOG4108NS2 receptor E3166_RS13905 ENOG4105C85 amino acid E3166_RS13910 ENOG4108N27 Glutathione S-transferase E3166_RS13920 ENOG4105CS6 Rhs element vgr protein E3166_RS13950 ENOG4108MEJ flavin reductase domain protein E3166_RS13960 ENOG4105JAB phenazine biosynthesis protein, phzf family E3166_RS13965 ENOG4105D0D Nitrate reductase 2, gamma subunit E3166_RS13970 ENOG4108NZN Respiratory nitrate reductase 2 delta chain E3166_RS13975 ENOG4108IUE nitrate reductase beta subunit E3166_RS13980 ENOG4105CRU nitrate reductase, alpha subunit E3166_RS13985 ENOG4107QND Nitrite extrusion protein E3166_RS13990 ENOG4108UI3 Leucine Rich repeat E3166_RS13995 ENOG4108UI3 Leucine Rich repeat E3166_RS14010 ENOG4105RPH Inner membrane protein YddG E3166_RS14020 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E3166_RS14025 ENOG4108MG3 formate dehydrogenase E3166_RS14030 ENOG41084S7 Plasmid maintenance system antidote protein E3166_RS14035 ENOG4105DQ4 alcohol dehydrogenase E3166_RS14045 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein E3166_RS14050 ENOG4105TPS biofilm-dependent modulation protein E3166_RS14055 ENOG4108Z9K Osmotically inducible protein E3166_RS14060 ENOG4107H6U ABC transporter E3166_RS14065 ENOG4105C3U ABC transporter E3166_RS14070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3166_RS14080 ENOG4105DEF Extracellular solute-binding protein, family 5 E3166_RS14085 ENOG4108UQS dipeptidase E3166_RS14090 ENOG4105BZU Histidine kinase E3166_RS14095 ENOG4105BZU Histidine kinase E3166_RS14100 ENOG4105F32 YngK protein E3166_RS14105 ENOG4105E5D amino acid E3166_RS14110 ENOG4105CVK Glutamate decarboxylase E3166_RS14115 ENOG4107RAN Peptidase, M16 E3166_RS14120 ENOG4105PE1 Receptor E3166_RS14125 ENOG4105CQ0 ABC transporter E3166_RS14135 ENOG4105C4X radical SAM domain protein E3166_RS14140 ENOG4105ENH Sulfatase E3166_RS14145 ENOG4108NKV transcriptional regulator E3166_RS14155 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit E3166_RS14160 ENOG4106PIH fimbrial-like protein ydeQ E3166_RS14165 ENOG4106318 fimbrial-like protein YdeR E3166_RS14170 ENOG4108WDE Fimbrial protein E3166_RS14175 ENOG4105CW0 outer membrane usher protein E3166_RS14185 ENOG4108RQP Major type 1 subunit fimbrin E3166_RS14205 ENOG4107RYS Autoinducer-2 (AI-2) kinase E3166_RS14215 ENOG4105C2J ABC transporter E3166_RS14220 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane E3166_RS14225 ENOG4105F5R ABC transporter E3166_RS14235 ENOG41061GT Aldolase E3166_RS14240 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound E3166_RS14250 ENOG4105FFC UPF0187 protein E3166_RS14260 ENOG4105BZU Histidine kinase E3166_RS14265 ENOG4105M0C cytoplasmic protein E3166_RS14270 ENOG4105CSV Glutaminase E3166_RS14275 ENOG4105C26 Dehydrogenase E3166_RS14280 ENOG4105EGI Transcriptional regulator E3166_RS14295 ENOG4105F27 Major Facilitator E3166_RS14300 ENOG41082NP Multiple antibiotic resistance E3166_RS14305 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes E3166_RS14310 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF E3166_RS14315 ENOG4106DNR multiple antibiotic resistance protein E3166_RS14320 ENOG4108594 Permease of the drug metabolite transporter E3166_RS14325 ENOG4105E5W Transporter E3166_RS14345 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria E3166_RS14350 ENOG4108YDI single-species biofilm formation on inanimate substrate E3166_RS14355 ENOG4108WTK competence damage-inducible protein E3166_RS14360 ENOG4105DGW oligopeptidase A E3166_RS14365 ENOG4105EMU Dehydrogenase E3166_RS14370 ENOG4107XBN GntR Family Transcriptional Regulator E3166_RS14375 ENOG41061EV selenium-binding protein YdfZ E3166_RS14380 ENOG4105DEI Mannitol dehydrogenase E3166_RS14415 ENOG4108X9F tail fiber protein E3166_RS14490 ENOG4105IM0 capsid protein E3166_RS14500 ENOG4105F7J membrane-bound serine protease E3166_RS14510 ENOG4107DE1 head-to-tail joining protein E3166_RS14515 ENOG4105UZW Tail fiber assembly protein E3166_RS14520 ENOG4105FKG DNA packaging protein E3166_RS14525 ENOG4106YSC E3166_RS14560 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS14595 ENOG4105KSK (crossover) junction endodeoxyribonuclease E3166_RS14600 ENOG4108MXB Protein of unknown function (DUF968) E3166_RS14615 ENOG4105WI6 cell killing protein encoded within cryptic prophage E3166_RS14655 ENOG41087BU transcriptional repressor DicA E3166_RS14690 ENOG4106G8A Qin prophage E3166_RS14705 ENOG4108I1J Integrase E3166_RS14710 ENOG4105EIF outer membrane protein W E3166_RS14720 ENOG4108S3I UPF0259 membrane protein E3166_RS14730 ENOG4105NAU thioesterase Superfamily protein E3166_RS14735 ENOG410822N TonB family E3166_RS14740 ENOG4105K9H YciI-like protein E3166_RS14745 ENOG4107SVH Potassium channel protein E3166_RS14765 ENOG4108JQ7 (ABC) transporter E3166_RS14770 ENOG4105C3U ABC transporter E3166_RS14775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3166_RS14780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3166_RS14785 ENOG4108J59 Extracellular solute-binding protein, family 5 E3166_RS14790 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein E3166_RS14795 ENOG4105C0A alcohol dehydrogenase E3166_RS14800 ENOG4107104 thymidine kinase E3166_RS14805 ENOG4108SAU DNA-binding protein H-ns E3166_RS14810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E3166_RS14815 ENOG4105I93 response regulator E3166_RS14820 ENOG4105D78 K07001 NTE family protein E3166_RS14830 ENOG4105CIY formyltetrahydrofolate deformylase E3166_RS14860 ENOG41076YT nitrate reductase, gamma subunit E3166_RS14865 ENOG4105R3A Nitrate reductase E3166_RS14870 ENOG4108IUE nitrate reductase beta subunit E3166_RS14875 ENOG4105CRU nitrate reductase, alpha subunit E3166_RS14880 ENOG4105DQQ Major facilitator superfamily MFS_1 E3166_RS14885 ENOG4105BZU Histidine kinase E3166_RS14890 ENOG4105WH1 Two component transcriptional regulator luxr family E3166_RS14895 ENOG4105ID0 Putative invasin E3166_RS14900 ENOG41090EX DsrE family E3166_RS14905 ENOG4108NH8 Cation transport protein E3166_RS14910 ENOG4105WS7 Cation transport regulator E3166_RS14915 ENOG4105EWV Sodium calcium exchanger membrane region E3166_RS14935 ENOG41063JG Transcriptional regulator E3166_RS14940 ENOG4108YY7 Invasion gene expression up-regulator SirB E3166_RS14955 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) E3166_RS14965 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E3166_RS14970 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E3166_RS14975 ENOG4105CHH sulfate transporter E3166_RS14980 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria E3166_RS14990 ENOG4105C3G gtp-binding protein E3166_RS14995 ENOG4105I1J Autotransporter E3166_RS15000 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family E3166_RS15005 ENOG4105CMT Dihydroxyacetone kinase E3166_RS15010 ENOG4108UTZ Dihydroxyacetone kinase E3166_RS15015 ENOG4105VDH Dihydroxyacetone kinase E3166_RS15030 ENOG4105S10 periplasmic binding protein E3166_RS15035 ENOG4105EHG Permease protein E3166_RS15040 ENOG4105E0A ABC, transporter E3166_RS15045 ENOG4108BSC Methyltransferase E3166_RS15050 ENOG4108PQF modD protein E3166_RS15075 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A E3166_RS15085 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E3166_RS15095 ENOG4105ED1 spovr family E3166_RS15110 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) E3166_RS15115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3166_RS15120 ENOG4105KT5 UmuD protein E3166_RS15125 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells E3166_RS15135 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E3166_RS15150 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium E3166_RS15155 ENOG4105S66 prophage protein E3166_RS15165 ENOG4107QMS site-determining protein E3166_RS15185 ENOG4108MGN ATP-binding component of a transport system E3166_RS15185 ENOG4108MGN ATP-binding component of a transport system E3166_RS15210 ENOG410658X E3166_RS15225 ENOG4105BZU Histidine kinase E3166_RS15230 ENOG410738I uncharacterized protein ymgC E3166_RS15240 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB E3166_RS15245 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component E3166_RS15250 ENOG4105BZU Histidine kinase E3166_RS15255 ENOG4108XDN Transcriptional regulator E3166_RS15260 ENOG41064WM Uncharacterized protein YcgX E3166_RS15275 ENOG4108HMX isocitrate dehydrogenase (NADP) E3166_RS15280 ENOG4105K5X acetyltransferase E3166_RS15290 ENOG4108NC2 Outer membrane protease E3166_RS15300 ENOG4105E5H Transposase E3166_RS15305 ENOG4108YXQ IS66 Orf2 family protein E3166_RS15320 ENOG4108WF3 methyltransferase E3166_RS15330 ENOG4108Z9Z response to DNA damage stimulus E3166_RS15335 ENOG4108N8X transition metal ion binding E3166_RS15340 ENOG4105WEF catalase E3166_RS15345 ENOG4105UZW Tail fiber assembly protein E3166_RS15350 ENOG4108X9F tail fiber protein E3166_RS15425 ENOG4105IM0 capsid protein E3166_RS15435 ENOG4105F7J membrane-bound serine protease E3166_RS15445 ENOG4107DE1 head-to-tail joining protein E3166_RS15450 ENOG4105UZW Tail fiber assembly protein E3166_RS15455 ENOG4105FKG DNA packaging protein E3166_RS15460 ENOG4106YSC E3166_RS15475 ENOG4105QYK bacteriophage lambda Bor protein homolog E3166_RS15505 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) E3166_RS15510 ENOG4105RWQ Protein of unknown function (DUF1364) E3166_RS15515 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 E3166_RS15520 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi E3166_RS15525 ENOG4107TII Recombinase E3166_RS15535 ENOG410814C multidrug resistance protein E3166_RS15560 ENOG4108I1J Integrase E3166_RS15565 ENOG4108HMX isocitrate dehydrogenase (NADP) E3166_RS15570 ENOG4108R99 pseudouridine synthase E3166_RS15580 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) E3166_RS15590 ENOG4107QTF adenylosuccinate lyase E3166_RS15595 ENOG4105XJC Two component transcriptional regulator (Winged helix family E3166_RS15600 ENOG4105IFJ Histidine kinase E3166_RS15610 ENOG4105FKG DNA packaging protein E3166_RS15625 ENOG4105IM0 capsid protein E3166_RS15700 ENOG4105EZE Cupin 4 family protein E3166_RS15710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E3166_RS15870 ENOG4106YSC E3166_RS15915 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS15945 ENOG4105HGD Antitermination protein E3166_RS15950 ENOG4105KSK (crossover) junction endodeoxyribonuclease E3166_RS15955 ENOG4108MXB Protein of unknown function (DUF968) E3166_RS15965 ENOG4105WI6 cell killing protein encoded within cryptic prophage E3166_RS16030 ENOG4105W7J DNA binding E3166_RS16035 ENOG410649Z repressor E3166_RS16055 ENOG4106G8A Qin prophage E3166_RS16070 ENOG4108I1J Integrase E3166_RS16075 ENOG4105D38 putrescine abc transporter E3166_RS16080 ENOG4107RUE extracellular solute-binding protein family 1 E3166_RS16085 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E3166_RS16095 ENOG4105D60 lipoprotein releasing system transmembrane protein E3166_RS16100 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E3166_RS16105 ENOG4105D60 lipoprotein releasing system transmembrane protein E3166_RS16110 ENOG4105IQC Inner membrane protein YcfT E3166_RS16115 ENOG4108JA2 transcriptioN-repair coupling factor E3166_RS16120 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E3166_RS16125 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction E3166_RS16130 ENOG4108IND Tetr family transcriptional regulator E3166_RS16135 ENOG4107MBR 17 kDa surface antigen E3166_RS16140 ENOG4105CEP NADH dehydrogenase E3166_RS16155 ENOG4108RUM thiamine kinase E3166_RS16160 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) E3166_RS16165 ENOG41090DQ Lipoprotein E3166_RS16170 ENOG4105K59 histidine triad (HIT) protein E3166_RS16180 ENOG4105CNM Receptor E3166_RS16185 ENOG4105CI1 PTS System E3166_RS16190 ENOG4105F8V Hydrolase, tatD family E3166_RS16195 ENOG4107QRG dna polymerase iii E3166_RS16205 ENOG4105HHA aminodeoxychorismate lyase E3166_RS16210 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E3166_RS16215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3166_RS16220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E3166_RS16225 ENOG4105CHR reductase E3166_RS16230 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E3166_RS16250 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E3166_RS16255 ENOG4108UHJ MAF-like protein E3166_RS16260 ENOG4105EI2 Pseudouridine synthase E3166_RS16265 ENOG4107QQB Ribonuclease E E3166_RS16270 ENOG4105DTJ flagellar hook-associated protein E3166_RS16275 ENOG4105E1Q flagellar hook-associated protein E3166_RS16280 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj E3166_RS16295 ENOG4105CGA flagellar basal-body rod protein FlgG E3166_RS16300 ENOG4108KPB Flagellar basal-body rod protein FlgF E3166_RS16305 ENOG4105BZE flagellar hook protein, FlgE E3166_RS16310 ENOG4105W00 Flagellar hook capping protein E3166_RS16315 ENOG4108ZC9 flagellar basal-body rod protein flgc E3166_RS16320 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) E3166_RS16325 ENOG4105CKS Flagella basal body P-ring formation protein flgA E3166_RS16330 ENOG4105M9M anti-sigma28 factor FlgM E3166_RS16335 ENOG4105QVD Flagella synthesis protein FlgN E3166_RS16340 ENOG4105CJR Integral membrane protein (MviN E3166_RS16345 ENOG4105EP9 oxidoreductase E3166_RS16355 ENOG4105D9U N-acetyltransferase E3166_RS16365 ENOG4105E9S glutaredoxin 2 E3166_RS16370 ENOG4105F3T (LipO)protein E3166_RS16380 ENOG4105MEA DNA damage-inducible protein i E3166_RS16385 ENOG4105PVA Biofilm formation regulatory protein BssS E3166_RS16395 ENOG4106974 biofilm formation E3166_RS16400 ENOG4105DS1 cytochrome b561 E3166_RS16405 ENOG4108YYC ycei family E3166_RS16415 ENOG4105D1S lipid A biosynthesis E3166_RS16425 ENOG4108W47 Acidic protein msyB E3166_RS16430 ENOG4105NAC (LipO)protein E3166_RS16435 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) E3166_RS16450 ENOG4107RZC phospholipase d E3166_RS16455 ENOG4108UVJ appr-1-p processing domain protein E3166_RS16470 ENOG41090QH cryptic curlin major subunit E3166_RS16475 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers E3166_RS16480 ENOG41086KC Transcriptional regulator E3166_RS16485 ENOG4108XDW curli assembly protein CsgE E3166_RS16490 ENOG4108WYR Curli production assembly transport component, CsgF E3166_RS16495 ENOG4105P8Q Curli production assembly transport component CsgG E3166_RS16500 ENOG4108UQ5 membrane protein YcdZ E3166_RS16505 ENOG4107XHZ cytoplasmic chaperone TorD family protein E3166_RS16545 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles E3166_RS16555 ENOG4108YGG dna repair protein E3166_RS16560 ENOG4106549 Antirestriction protein E3166_RS16565 ENOG4106H6R UPF0380 protein E3166_RS16575 ENOG4108YIV E3166_RS16580 ENOG4108F5E vimentin E3166_RS16640 ENOG4105D5K Hemolysin activator protein E3166_RS16725 ENOG4105D05 Receptor E3166_RS16785 ENOG4105DAX Pfam:DUF2983 E3166_RS16820 ENOG4105E5H Transposase E3166_RS16825 ENOG4108YXQ IS66 Orf2 family protein E3166_RS16860 ENOG4105E5H Transposase E3166_RS16865 ENOG4108YXQ IS66 Orf2 family protein E3166_RS16905 ENOG41080IJ Diacylglycerol kinase E3166_RS16910 ENOG4105DIJ Phosphoethanolamine transferase E3166_RS16920 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) E3166_RS16965 ENOG4105NRA 50s ribosomal protein l31 type b E3166_RS17000 ENOG4108P8R E3166_RS17025 ENOG4105DFP Integrase E3166_RS17030 ENOG4108T85 Membrane E3166_RS17075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E3166_RS17080 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) E3166_RS17090 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) E3166_RS17100 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) E3166_RS17105 ENOG4105D5K Hemolysin activator protein E3166_RS17110 ENOG4105CKT filamentous hemagglutinin E3166_RS17120 ENOG4105X0I Fimbrial E3166_RS17125 ENOG4108AF8 Chaperone E3166_RS17130 ENOG4105CW0 outer membrane usher protein E3166_RS17140 ENOG4108MQF Chaperone E3166_RS17145 ENOG4105CHR reductase E3166_RS17150 ENOG4108TC1 Transcriptional regulator E3166_RS17160 ENOG4105CXC rtn protein E3166_RS17165 ENOG4105BZU Histidine kinase E3166_RS17170 ENOG4108TUY outer membrane protein PgaA E3166_RS17175 ENOG4107BJW polysaccharide deacetylase E3166_RS17180 ENOG4105CND Glycosyl transferase, family 2 E3166_RS17190 ENOG4105D5M phosphate starvation-inducible protein E3166_RS17195 ENOG4105DBE peroxidase E3166_RS17200 ENOG410650H (LipO)protein E3166_RS17215 ENOG4105CK7 Sodium proline symporter E3166_RS17225 ENOG4105C26 Dehydrogenase E3166_RS17230 ENOG4108R86 Transcriptional regulator E3166_RS17265 ENOG4105C2W permease E3166_RS17270 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 E3166_RS17280 ENOG4105XH3 E3166_RS17285 ENOG4105D6F Phosphatase E3166_RS17310 ENOG4108J2R molybdopterin oxidoreductase E3166_RS17315 ENOG4105CUW cytochrome C-TYPE protein E3166_RS17320 ENOG4106WF9 DNA-binding transcriptional regulator TorR E3166_RS17325 ENOG4108SV3 Tmao reductase system periplasmic protein tort E3166_RS17330 ENOG4105BZU Histidine kinase E3166_RS17335 ENOG4105HEE Binding Domain protein E3166_RS17340 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation E3166_RS17355 ENOG4105VEQ Cold shock protein E3166_RS17360 ENOG41060EU Cold shock-like protein E3166_RS17370 ENOG4108Y9B (LipO)protein E3166_RS17375 ENOG4108W78 Pfam:DUF1017 E3166_RS17380 ENOG4105E3R (LipO)protein E3166_RS17385 ENOG4105DAY polysaccharide export protein E3166_RS17390 ENOG4107ZF2 Phosphatase E3166_RS17395 ENOG4108F2G Chain length determinant protein E3166_RS17400 ENOG4105D6F Phosphatase E3166_RS17410 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E3166_RS17415 ENOG4105C4M (Ubiquinol oxidase) subunit I E3166_RS17420 ENOG4105MVP hydrogenase-1 operon protein HyaF E3166_RS17425 ENOG4108VXY Hydrogenase-1 operon protein HyaE E3166_RS17430 ENOG4108USZ hydrogenase E3166_RS17435 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E3166_RS17440 ENOG4105DPX Hydrogenase, large subunit E3166_RS17445 ENOG4105E3S small subunit E3166_RS17465 ENOG4108X9F tail fiber protein E3166_RS17480 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E3166_RS17525 ENOG4105IM0 capsid protein E3166_RS17560 ENOG4105E5H Transposase E3166_RS17565 ENOG4108YXQ IS66 Orf2 family protein E3166_RS17590 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS17665 ENOG4105HRS Antitermination protein E3166_RS17670 ENOG4105KSK (crossover) junction endodeoxyribonuclease E3166_RS17675 ENOG4108MXB Protein of unknown function (DUF968) E3166_RS17710 ENOG4105JBR DNA replication protein E3166_RS17770 ENOG4106G8A Qin prophage E3166_RS17790 ENOG4108MN8 Membrane E3166_RS17795 ENOG4108Z0T Part of a sulfur-relay system (By similarity) E3166_RS17800 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E3166_RS17815 ENOG4105K4P CoA-binding domain protein E3166_RS17830 ENOG41088T4 Helicase IV E3166_RS17835 ENOG410901E Membrane E3166_RS17840 ENOG4105EM2 membrane E3166_RS17845 ENOG4108RZ1 DNA transformation protein E3166_RS17855 ENOG4105UYK outer membrane protein a E3166_RS17865 ENOG4105DAN ATP-dependent protease E3166_RS17875 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) E3166_RS17880 ENOG4108Q2G (LipO)protein E3166_RS17885 ENOG4105DY2 Paraquat-inducible protein b E3166_RS17890 ENOG4105F1S paraquat-inducible protein a E3166_RS17895 ENOG4105C5H ABC transporter E3166_RS17905 ENOG4105QVC MOSC domain-containing protein E3166_RS17910 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) E3166_RS17925 ENOG4105MX3 Fimbrial E3166_RS17930 ENOG4105Q7J Fimbrial E3166_RS17935 ENOG4108MDY Fimbrial E3166_RS17945 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae E3166_RS17950 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon E3166_RS17955 ENOG4108UZX fmn reductase E3166_RS17960 ENOG4105GVF (ABC) transporter E3166_RS17970 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E3166_RS17975 ENOG4105E2Y ABC, transporter E3166_RS17980 ENOG4105CD8 aminopeptidase N E3166_RS17990 ENOG4105C5S asparaginyl-tRNA synthetase E3166_RS17995 ENOG4105FCK Membrane E3166_RS18000 ENOG4105CGF Aromatic amino acid aminotransferase E3166_RS18005 ENOG4105C5X domain protein E3166_RS18010 ENOG4105EAQ (twin-arginine translocation) pathway signal E3166_RS18015 ENOG4105DIT ErfK YbiS YcfS YnhG family protein E3166_RS18025 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) E3166_RS18035 ENOG4106371 Methyltransferase E3166_RS18040 ENOG4107S90 membrAne E3166_RS18045 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups E3166_RS18060 ENOG4105T0Z Conserved Protein E3166_RS18070 ENOG4105BZ1 (ABC) transporter E3166_RS18075 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E3166_RS18085 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E3166_RS18095 ENOG4108K0D peptidase, M48 E3166_RS18110 ENOG4107VMU Membrane E3166_RS18115 ENOG4105DDY UPF0142 protein ycaO E3166_RS18120 ENOG4105TMB Formate nitrite transporter E3166_RS18125 ENOG4105C6N Formate acetyltransferase E3166_RS18130 ENOG4105F1A Pyruvate formate-lyase E3166_RS18140 ENOG4105E5D amino acid E3166_RS18150 ENOG4105CHJ isochorismatase hydrolase E3166_RS18155 ENOG4107KGK dmso reductase anchor subunit E3166_RS18160 ENOG4105QAX Iron-sulfur E3166_RS18165 ENOG4107QY8 reductase E3166_RS18175 ENOG4105D1H recombination factor protein RarA E3166_RS18185 ENOG4105CNU cell division protein FtsK E3166_RS18195 ENOG4105C3M thioredoxin reductase E3166_RS18200 ENOG4108JJ9 ABC, transporter E3166_RS18205 ENOG4108JJ8 (ABC) transporter E3166_RS18215 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E3166_RS18225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E3166_RS18235 ENOG4105VEQ Cold shock protein E3166_RS18240 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E3166_RS18245 ENOG4105DJY efflux transporter, rnd family, mfp subunit E3166_RS18250 ENOG4108MJ5 VirK protein E3166_RS18255 ENOG4105CPB ATP-dependent endonuclease of the OLD family E3166_RS18260 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E3166_RS18265 ENOG4105DWU Membrane E3166_RS18275 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E3166_RS18280 ENOG4105C7K acetolactate synthase E3166_RS18285 ENOG4105C5W Aldolase E3166_RS18290 ENOG4105CGD Nad-dependent epimerase dehydratase E3166_RS18295 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase E3166_RS18300 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E3166_RS18315 ENOG41064MM (LipO)protein E3166_RS18320 ENOG4105E5Z arginine transporter ATP-binding subunit E3166_RS18325 ENOG4106PMH Extracellular solute-binding protein family 3 E3166_RS18330 ENOG4105GBT ABC transporter E3166_RS18335 ENOG4105DMR ABC, transporter E3166_RS18340 ENOG4106TNF Periplasmic binding protein E3166_RS18365 ENOG4105RBQ inner membrane protein ybjO E3166_RS18370 ENOG4105D38 putrescine abc transporter E3166_RS18375 ENOG4105F38 ABC transporter, permease E3166_RS18380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E3166_RS18385 ENOG4107RUE extracellular solute-binding protein family 1 E3166_RS18390 ENOG4108RMJ sensory transduction regulator E3166_RS18400 ENOG4108DBC nitroreductase E3166_RS18405 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress E3166_RS18410 ENOG41090BQ Glutaredoxin E3166_RS18415 ENOG4105GWF inner membrane protein YbjM E3166_RS18425 ENOG4108RFG Tetr family transcriptional regulator E3166_RS18430 ENOG4106UW1 Major Facilitator superfamily E3166_RS18435 ENOG4108HCJ Hydrolase E3166_RS18450 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E3166_RS18455 ENOG4107FB0 transcriptional regulator DeoR family E3166_RS18460 ENOG4105DZ1 carboxypeptidase E3166_RS18465 ENOG4108TGY Glutathione S-transferase E3166_RS18470 ENOG4105D8V Glucose sorbosone dehydrogenase E3166_RS18475 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway E3166_RS18495 ENOG41064RH membrane protein YliF E3166_RS18500 ENOG4105BZU Histidine kinase E3166_RS18510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3166_RS18515 ENOG4105DEF Extracellular solute-binding protein, family 5 E3166_RS18520 ENOG4108JQ6 ABC transporter E3166_RS18530 ENOG4105CVM Molybdenum cofactor synthesis domain protein E3166_RS18535 ENOG4105D06 uba thif-type nad fad binding protein E3166_RS18540 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3166_RS18545 ENOG4105F1A Pyruvate formate-lyase E3166_RS18555 ENOG4108HCJ Hydrolase E3166_RS18560 ENOG41072TH Protein of unknown function (DUF1479) E3166_RS18565 ENOG4105C5H ABC transporter E3166_RS18570 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E3166_RS18575 ENOG4105F4P )-transporter E3166_RS18580 ENOG4105KST dependent repressor E3166_RS18590 ENOG4108I6E Sulfatase E3166_RS18595 ENOG4108T1M outer membrane protein x E3166_RS18605 ENOG4107AQZ Membrane E3166_RS18615 ENOG4107R0W ABC transporter E3166_RS18620 ENOG4105E5Q amino acid AbC transporter E3166_RS18625 ENOG4105CDA abc transporter atp-binding protein E3166_RS18630 ENOG4105D8X mechanosensitive ion channel E3166_RS18640 ENOG4105ZY9 UPF0379 protein ybiM E3166_RS18645 ENOG4108ESX Receptor E3166_RS18655 ENOG4105KSC Transcriptional regulator, TraR DksA family E3166_RS18660 ENOG4105VR4 UPF0379 protein ybiJ E3166_RS18665 ENOG4105DG4 malate L-lactate dehydrogenase E3166_RS18670 ENOG4108MTB glycosyl transferase family E3166_RS18675 ENOG4105DVT helicase E3166_RS18685 ENOG4105C1J atp-dependent rna helicase E3166_RS18690 ENOG4107MVR Transcriptional regulator E3166_RS18700 ENOG4105CJ1 ABC, transporter E3166_RS18705 ENOG4107QWP ABC-2 type transporter E3166_RS18710 ENOG4107QWP ABC-2 type transporter E3166_RS18715 ENOG4105I9U inner membrane protein ybhQ E3166_RS18720 ENOG4105X23 Endonuclease Exonuclease phosphatase E3166_RS18725 ENOG4105DZQ phospholipase D Transphosphatidylase E3166_RS18730 ENOG4107UXM Membrane E3166_RS18735 ENOG410733J conserved inner membrane protein E3166_RS18740 ENOG4105HFZ Membrane E3166_RS18745 ENOG4108ZAF Molybdopterin E3166_RS18750 ENOG4105M00 molybdopterin converting factor, subunit 1 E3166_RS18760 ENOG4108RIR Molybdenum cofactor biosynthesis protein E3166_RS18770 ENOG4105CHW UPF0052 protein E3166_RS18780 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E3166_RS18785 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E3166_RS18800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E3166_RS18805 ENOG4108V1U phospholipid-binding protein E3166_RS18820 ENOG4105UZW Tail fiber assembly protein E3166_RS18845 ENOG4108X9F tail fiber protein E3166_RS18880 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E3166_RS18885 ENOG4105KUS lysozyme E3166_RS18890 ENOG4105QFS Lysis protein S homolog from lambdoid prophage E3166_RS18930 ENOG4108R1E Serine threonine protein phosphatase 1 E3166_RS19005 ENOG4108I1J Integrase E3166_RS19010 ENOG4105NBR Pectinesterase E3166_RS19015 ENOG4107QM5 aconitate hydratase E3166_RS19020 ENOG4107QPK )-transporter E3166_RS19025 ENOG4105C7F AcnD-accessory protein PrpF E3166_RS19030 ENOG4105F04 LysR family Transcriptional regulator E3166_RS19040 ENOG4108K4B hydrolase E3166_RS19050 ENOG4105E0C molybdate abc transporter E3166_RS19055 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E3166_RS19065 ENOG4105F4R Transcriptional regulator mode E3166_RS19070 ENOG4105DKW ABC transporter E3166_RS19075 ENOG4105CMR udp-glucose 4-epimerase E3166_RS19080 ENOG4105F0Z galactose-1-phosphate uridylyltransferase E3166_RS19090 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E3166_RS19100 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E3166_RS19105 ENOG4105JND homeobox protein E3166_RS19110 ENOG4105PGM cation diffusion facilitator family transporter E3166_RS19115 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E3166_RS19120 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) E3166_RS19155 ENOG4105UFD tol-pal system protein YbgF E3166_RS19160 ENOG4105KCK Peptidoglycan-associated lipoprotein E3166_RS19170 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA E3166_RS19180 ENOG4105E02 MotA TolQ exbB proton channel E3166_RS19185 ENOG4107YD3 Thioesterase E3166_RS19190 ENOG4105KJB cyd operon protein YbgE E3166_RS19200 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E3166_RS19205 ENOG4105C4M (Ubiquinol oxidase) subunit I E3166_RS19220 ENOG4107WFU Glutamate mutase subunit sigma E3166_RS19230 ENOG4105DJI Methylaspartate mutase, E subunit E3166_RS19255 ENOG4107GFK fumarate E3166_RS19260 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E3166_RS19265 ENOG4105ETT transcriptional Regulator, LysR family E3166_RS19270 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E3166_RS19280 ENOG4105C7S Dehydrogenase E3166_RS19285 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E3166_RS19290 ENOG4105E33 succinate dehydrogenase E3166_RS19295 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E3166_RS19300 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E3166_RS19305 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E3166_RS19315 ENOG4105BZN citrate synthase E3166_RS19320 ENOG4106UBK fimbrial-like adhesin protein E3166_RS19325 ENOG4106PG1 outer membrane usher protein E3166_RS19330 ENOG4108TTM chaperone E3166_RS19335 ENOG4108MY7 Fimbrial E3166_RS19340 ENOG4108KK1 membrane protein AbrB duplication E3166_RS19345 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) E3166_RS19355 ENOG4107R7A Allophanate hydrolase subunit 2 E3166_RS19360 ENOG4105P4J Allophanate hydrolase, subunit 1 E3166_RS19365 ENOG4107QNR UPF0135 protein E3166_RS19370 ENOG4105DUX Transporter E3166_RS19375 ENOG4105CVP deoxyribo-dipyrimidine photolyase E3166_RS19380 ENOG4107SEY Conserved Protein E3166_RS19385 ENOG410600T transposase E3166_RS19395 ENOG4106R09 E3166_RS19400 ENOG4105CNA YD repeat protein E3166_RS19405 ENOG4105XIQ Protein of unknown function (DUF2517) E3166_RS19430 ENOG4105C08 Histidine kinase E3166_RS19435 ENOG4105EEX Two component transcriptional regulator (Winged helix family E3166_RS19445 ENOG4105CXN decarboxylase E3166_RS19450 ENOG4105D5Q Arginine ornithine antiporter E3166_RS19455 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 E3166_RS19460 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) E3166_RS19465 ENOG4105EV9 Alpha Beta Hydrolase E3166_RS19470 ENOG4105NNH LexA regulated protein E3166_RS19475 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) E3166_RS19485 ENOG41090R7 Ferric uptake E3166_RS19505 ENOG4105CI1 PTS System E3166_RS19515 ENOG4105CE4 GlcNAc 6-P deacetylase E3166_RS19520 ENOG4105E2R ROK family E3166_RS19525 ENOG4105D4U had-superfamily hydrolase, subfamily iia E3166_RS19530 ENOG4105CAQ asparagine synthetase E3166_RS19570 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E3166_RS19580 ENOG4105C9A Phoh family E3166_RS19590 ENOG4108JU5 Magnesium and cobalt efflux protein E3166_RS19595 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E3166_RS19600 ENOG4107RP9 extracellular solute-binding protein, family 3 E3166_RS19605 ENOG4105EAD ABC transporter E3166_RS19610 ENOG4105DRP amino acid AbC transporter E3166_RS19615 ENOG4105CDA abc transporter atp-binding protein E3166_RS19625 ENOG4105F7F Chaperone E3166_RS19635 ENOG41069CF Protein of unknown function (DUF1266) E3166_RS19640 ENOG4107JFD Sel1 repeat E3166_RS19645 ENOG4105QFC Hsc56 co-chaperone of HscC E3166_RS19650 ENOG41069CF Protein of unknown function (DUF1266) E3166_RS19660 ENOG4107PAI alpha helical protein E3166_RS19675 ENOG4105DJF DNA polymerase III, delta' subunit E3166_RS19685 ENOG4108TGR phosphatase E3166_RS19690 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E3166_RS19700 ENOG4105CJN penicillin-binding protein E3166_RS19705 ENOG4105CNI cell division protein FtsW E3166_RS19710 ENOG4105K6T rare lipoprotein A E3166_RS19715 ENOG4105DZ1 carboxypeptidase E3166_RS19730 ENOG41064T2 transcriptional regulator, lysR family E3166_RS19740 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) E3166_RS19760 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) E3166_RS19765 ENOG4105CEE C4-dicarboxylate transporter E3166_RS19770 ENOG4106YYS transcriptional regulatory protein E3166_RS19775 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E3166_RS19780 ENOG4105DUA (citrate (pro-3S)-lyase ligase E3166_RS19790 ENOG4105CI0 Citrate lyase E3166_RS19795 ENOG4105CHY citrate lyase, alpha E3166_RS19805 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E3166_RS19810 ENOG4107QPK )-transporter E3166_RS19815 ENOG4105KTS ribonuclease E3166_RS19820 ENOG4105NXH GreA GreB family elongation factor E3166_RS19825 ENOG4105E2A Dehydrogenase E3166_RS19830 ENOG4108U51 Universal stress protein E3166_RS19835 ENOG4108JU3 Alkyl hydroperoxide reductase E3166_RS19840 ENOG4105D3R alkyl hydroperoxide reductase E3166_RS19845 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E3166_RS19850 ENOG4105DQS Transcriptional regulator E3166_RS19855 ENOG4105BZV Phosphoadenosine phosphosulfate reductase E3166_RS19860 ENOG4105GTN ParB Domain Protein Nuclease E3166_RS19865 ENOG4105CHM Aminotransferase E3166_RS19870 ENOG4107SCQ Iron-containing alcohol dehydrogenase E3166_RS19875 ENOG4105VCD cytoplasmic protein E3166_RS19880 ENOG4105D22 carbon starvation protein E3166_RS19890 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E3166_RS19895 ENOG4105WQI isochorismatase E3166_RS19900 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E3166_RS19905 ENOG4105E4F Isochorismate synthase E3166_RS19910 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein E3166_RS19920 ENOG4105DQ5 transport system permease protein E3166_RS19925 ENOG4105TVJ transport system, permease E3166_RS19930 ENOG4105E0A ABC, transporter E3166_RS19935 ENOG4108QY5 Ferric enterobactin transport protein E3166_RS19940 ENOG4105C0W non-ribosomal peptide synthetase E3166_RS19945 ENOG41085A6 mbth domain-containing protein E3166_RS19950 ENOG4105E93 esterase E3166_RS19955 ENOG4107RNH Outer membrane receptor FepA E3166_RS19960 ENOG4108TSE Transferase E3166_RS19970 ENOG4107635 Hok Gef family protein E3166_RS19980 ENOG4105WQ6 Membrane E3166_RS19985 ENOG4105MSB protein, conserved in bacteria E3166_RS19990 ENOG4108RCM Nitroreductase E3166_RS19995 ENOG4105CUY Mechanosensitive ion channel E3166_RS20000 ENOG4105C85 amino acid E3166_RS20005 ENOG4108IJF Heavy metal efflux pump, CzcA E3166_RS20010 ENOG4105EP1 Efflux transporter rnd family, mfp subunit E3166_RS20015 ENOG410624V efflux system protein E3166_RS20020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E3166_RS20025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3166_RS20030 ENOG4105GR3 Histidine kinase E3166_RS20035 ENOG4105CS6 Rhs element vgr protein E3166_RS20045 ENOG4105CNA YD repeat protein E3166_RS20055 ENOG4105CNA YD repeat protein E3166_RS20065 ENOG410600T transposase E3166_RS20070 ENOG410802X bacteriophage n4 adsorption protein b E3166_RS20075 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit E3166_RS20080 ENOG4105QUW E3166_RS20095 ENOG4108Q9V regulatoR E3166_RS20100 ENOG4108ZI2 Fimbrial protein E3166_RS20105 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) E3166_RS20110 ENOG4105CW0 outer membrane usher protein E3166_RS20115 ENOG4108AF8 Chaperone E3166_RS20120 ENOG4108WDE Fimbrial protein E3166_RS20130 ENOG4105WQ3 Rna-binding protein E3166_RS20135 ENOG4105S2T inner membrane protein YbcI E3166_RS20145 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E3166_RS20155 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E3166_RS20160 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E3166_RS20165 ENOG4105C5B carbamate kinase E3166_RS20170 ENOG4105G5A Protein of unknown function (DUF2877) E3166_RS20175 ENOG4107REC cytoplasmic protein E3166_RS20180 ENOG4107R1Q Membrane protein FdrA E3166_RS20190 ENOG4105CE7 Amidase, hydantoinase carbamoylase family E3166_RS20195 ENOG4105S0E allantoin catabolism protein E3166_RS20200 ENOG4105BZW Glycerate kinase E3166_RS20205 ENOG4105DTE Xanthine uracil vitamin C permease E3166_RS20215 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E3166_RS20220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E3166_RS20225 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E3166_RS20230 ENOG41060W2 glyoxylate carboligase E3166_RS20235 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region E3166_RS20245 ENOG4107653 Transcriptional regulator E3166_RS20265 ENOG4105CNA YD repeat protein E3166_RS20270 ENOG4105CV6 ABC transporter, permease E3166_RS20275 ENOG4108I0Y (ABC) transporter E3166_RS20280 ENOG4108UJV acyl-CoA thioesterase i E3166_RS20285 ENOG4105E1F short-chain dehydrogenase reductase E3166_RS20290 ENOG4107QR8 Thioredoxin E3166_RS20295 ENOG4105C4B ABC transporter, permease E3166_RS20300 ENOG41083J0 (ABC) transporter E3166_RS20305 ENOG4107QX8 SPFH domain, Band 7 family protein E3166_RS20310 ENOG4105G5H Membrane E3166_RS20335 ENOG4107QZV Type I secretion membrane fusion protein E3166_RS20355 ENOG4107RY6 amino acid E3166_RS20360 ENOG4105CSV Glutaminase E3166_RS20365 ENOG4105C59 p-type ATPase E3166_RS20370 ENOG41081XE plasmid maintenance system antidote protein, xre family E3166_RS20375 ENOG4105MBR gumn family E3166_RS20380 ENOG4108Z66 YbaK ebsC protein E3166_RS20385 ENOG4105CGH 5'-nucleotidase E3166_RS20390 ENOG4105EU0 Major facilitator Superfamily E3166_RS20395 ENOG4105CKD glutathione-regulated potassium-efflux system protein E3166_RS20400 ENOG4107RE1 Inosine-guanosine kinase E3166_RS20435 ENOG4107QMP dna polymerase iii subunits gamma and tau E3166_RS20445 ENOG4105WD1 Membrane E3166_RS20450 ENOG4108URS primosomal replication protein n'' E3166_RS20455 ENOG4106428 Protein of unknown function (DUF2496) E3166_RS20460 ENOG4105EGS Mechanosensitive ion channel E3166_RS20465 ENOG4107XI7 Tetr family transcriptional regulator E3166_RS20470 ENOG4105C1P efflux transporter, rnd family, mfp subunit E3166_RS20475 ENOG4105BZS acriflavin resistance protein E3166_RS20480 ENOG4108UKR Biofilm formation regulator YbaJ E3166_RS20485 ENOG4105KF5 hemolysin expression-modulating protein E3166_RS20490 ENOG4108UW5 maltose o-acetyltransferase E3166_RS20495 ENOG4105GSJ Inner membrane protein ylaC E3166_RS20500 ENOG41066DG (EAL) domain protein E3166_RS20505 ENOG4105KCV RNA signal recognition particle 4.5S RNA E3166_RS20515 ENOG41080UX Methyltransferase E3166_RS20520 ENOG4108MNP Glycoprotein polysaccharide metabolism E3166_RS20525 ENOG4105C29 acyl-CoA thioesterase E3166_RS20530 ENOG4105BZU Histidine kinase E3166_RS20535 ENOG4108YZA Nitrogen regulatory protein pii E3166_RS20540 ENOG4105BZ1 (ABC) transporter E3166_RS20545 ENOG4105BZ1 (ABC) transporter E3166_RS20550 ENOG4108XM1 transcriptional regulator AsnC family E3166_RS20560 ENOG4108NFA extracellular solute-binding protein E3166_RS20570 ENOG4108TGP Thioesterase superfamily protein E3166_RS20575 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E3166_RS20580 ENOG4105EIN peptidylprolyl cis-trans isomerase E3166_RS20585 ENOG4105K70 DNA-binding protein E3166_RS20590 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) E3166_RS20610 ENOG4105M85 Bola protein E3166_RS20615 ENOG4105IEY (LipO)protein E3166_RS20620 ENOG4105EYM Major Facilitator superfamily E3166_RS20625 ENOG4105E2S oxidase) subunit II E3166_RS20630 ENOG4105BZ9 Cytochrome C oxidase, subunit I E3166_RS20635 ENOG4105CCU oxidase (Subunit III) E3166_RS20640 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E3166_RS20650 ENOG4107RDB Major Facilitator E3166_RS20660 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3166_RS20665 ENOG4107S0N DJ-1 family E3166_RS20680 ENOG4105CTB Polyprenyl synthetase E3166_RS20690 ENOG4105CPC Aldo Keto reductase E3166_RS20700 ENOG4108ZAI phosphatidylglycerophosphatase a E3166_RS20705 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E3166_RS20715 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) E3166_RS20720 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E3166_RS20730 ENOG4108KIC (LipO)protein E3166_RS20735 ENOG4105DRB nucleoside-specific channel-forming protein E3166_RS20740 ENOG4105N1F Hnh endonuclease E3166_RS20750 ENOG4105X54 addiction module antidote protein E3166_RS20755 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E3166_RS20760 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E3166_RS20765 ENOG4105VIE preprotein translocase, subunit YajC E3166_RS20790 ENOG4107R28 alpha amylase, catalytic region E3166_RS20795 ENOG4105C85 amino acid E3166_RS20800 ENOG4105CWM branched-chain amino acid transport system II carrier protein E3166_RS20805 ENOG4105BZU Histidine kinase E3166_RS20810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3166_RS20815 ENOG4107RH8 nuclease SbcCD subunit D E3166_RS20820 ENOG4105EYH Exonuclease E3166_RS20825 ENOG4105F27 Major Facilitator E3166_RS20830 ENOG4105DKQ ROK family E3166_RS20855 ENOG4105HBA AroM protein E3166_RS20860 ENOG4105SS3 E3166_RS20875 ENOG4105II7 pyrroline-5-carboxylate reductase E3166_RS20880 ENOG4105BZU Histidine kinase E3166_RS20885 ENOG4105VIF phosphate starvation-inducible protein E3166_RS20890 ENOG4105G6Z alkaline phosphatase E3166_RS20905 ENOG4105CPF Cell wall formation (By similarity) E3166_RS20910 ENOG4105UNH Membrane E3166_RS20915 ENOG4105FR5 inner membrane protein YaiY E3166_RS20920 ENOG4107QS8 (LipO)protein E3166_RS20925 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 E3166_RS20930 ENOG4107R6D beta-lactam binding protein AmpH E3166_RS20935 ENOG4108PNB DNA-binding transcriptional regulator E3166_RS20945 ENOG4105D52 delta-aminolevulinic acid dehydratase E3166_RS20950 ENOG4105E2B Taurine dioxygenase E3166_RS20955 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E3166_RS20960 ENOG4108ETV ABC transporter E3166_RS20965 ENOG4106FTQ Taurine ABC transporter, periplasmic E3166_RS20970 ENOG4108KX4 response regulator E3166_RS20975 ENOG4105BZU Histidine kinase E3166_RS20980 ENOG4105CXY transporter E3166_RS20985 ENOG4105C4Y ABC transporter E3166_RS20990 ENOG4107RCV ABC transporter, permease E3166_RS20995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E3166_RS21010 ENOG4105C4W S-formylglutathione hydrolase E3166_RS21015 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E3166_RS21020 ENOG4108SC4 )-transporter E3166_RS21025 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) E3166_RS21040 ENOG4106HB6 Alpha beta hydrolase E3166_RS21055 ENOG4108K2P TRANSCRIPTIONal E3166_RS21060 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein E3166_RS21070 ENOG4105ETE Transcriptional regulator (LacI family E3166_RS21075 ENOG4105CNT hydrolase family 2 E3166_RS21080 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) E3166_RS21085 ENOG4108UW5 maltose o-acetyltransferase E3166_RS21090 ENOG4105DJ2 Major Facilitator Superfamily E3166_RS21100 ENOG4107B2H carbonic anhydrase E3166_RS21105 ENOG4105DND Transcriptional regulator E3166_RS21110 ENOG4105DZC cytosine deaminase E3166_RS21115 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin E3166_RS21120 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E3166_RS21125 ENOG4105DXD 2-methylcitrate dehydratase E3166_RS21130 ENOG4105BZN citrate synthase E3166_RS21135 ENOG4105CR4 methylisocitrate lyase E3166_RS21140 ENOG4108JU7 Transcriptional regulator E3166_RS21145 ENOG4105TDT uncharacterized protein yahO E3166_RS21150 ENOG4105E82 cytochrome subunit of dehydrogenase E3166_RS21165 ENOG4105DQ4 alcohol dehydrogenase E3166_RS21170 ENOG4105CNN ABC, transporter E3166_RS21175 ENOG4105CNN ABC, transporter E3166_RS21180 ENOG4105C2J ABC transporter E3166_RS21185 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E3166_RS21195 ENOG4105DZC cytosine deaminase E3166_RS21200 ENOG4105C5B carbamate kinase E3166_RS21210 ENOG4107REC cytoplasmic protein E3166_RS21215 ENOG4107R1Q Membrane protein FdrA E3166_RS21220 ENOG4105N16 Protein of unknown function (DUF2877) E3166_RS21225 ENOG4107SNB ankyrin repeat protein YahD E3166_RS21240 ENOG4105BZU Histidine kinase E3166_RS21250 ENOG4105C94 Transporter E3166_RS21285 ENOG4105BZU Histidine kinase E3166_RS21310 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) E3166_RS21315 ENOG4107QR9 Iron-sulfur cluster binding protein E3166_RS21320 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E3166_RS21325 ENOG4108K01 transcriptional regulator E3166_RS21330 ENOG4107QN2 dihydrolipoyl dehydrogenase E3166_RS21335 ENOG41066GK UPF0379 protein ykgI E3166_RS21340 ENOG4108KBJ Inner membrane protein YkgB E3166_RS21345 ENOG4105CV8 reductase E3166_RS21380 ENOG410642W LysR family Transcriptional regulator E3166_RS21385 ENOG4105ENX hydrolase E3166_RS21410 ENOG4105E5H Transposase E3166_RS21415 ENOG4108YXQ IS66 Orf2 family protein E3166_RS21445 ENOG4108GWT fimbrillin MatB E3166_RS21455 ENOG4108N3D putative enzyme E3166_RS21460 ENOG4106PYX Receptor E3166_RS21465 ENOG4108UD7 cell wall organization E3166_RS21470 ENOG4105PI0 Ferredoxin E3166_RS21475 ENOG4105R3P Inner membrane protein yagU E3166_RS21480 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit E3166_RS21485 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding E3166_RS21490 ENOG4105C7W Xanthine dehydrogenase E3166_RS21495 ENOG4107XAN XdhC and CoxI family E3166_RS21500 ENOG4107RTG Major Facilitator superfamily E3166_RS21505 ENOG4105ENX hydrolase E3166_RS21510 ENOG4105EQ2 LysR family Transcriptional regulator E3166_RS21520 ENOG4105EMU Dehydrogenase E3166_RS21610 ENOG4105ESI atpase involved in dna repair E3166_RS21615 ENOG4105TS0 gtp-binding protein E3166_RS21620 ENOG4108KZE transcriptional regulator E3166_RS21645 ENOG4106H6R UPF0380 protein E3166_RS21650 ENOG4106549 Antirestriction protein E3166_RS21655 ENOG4108YGG dna repair protein E3166_RS21700 ENOG4105FCK Membrane E3166_RS21720 ENOG4105CIN aminoacyl-histidine dipeptidase E3166_RS21725 ENOG4108S2Y peptide Chain Release factor E3166_RS21735 ENOG4108HYG acetyltransferase E3166_RS21740 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome E3166_RS21745 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system E3166_RS21750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3166_RS21770 ENOG4108YS0 lipoprotein YafL E3166_RS21780 ENOG4105VXN addiction module toxin, RelE StbE family E3166_RS21785 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E3166_RS21790 ENOG4105E7A Glutamine amidotransferase E3166_RS21800 ENOG4107QPN acyl-Coa dehydrogenase E3166_RS21805 ENOG4108WN0 inhibitor of vertebrate lysozyme E3166_RS21810 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E3166_RS21815 ENOG410600T transposase E3166_RS21830 ENOG4107TV1 YD repeat protein E3166_RS21835 ENOG410600T transposase E3166_RS21845 ENOG4105CNA YD repeat protein E3166_RS21855 ENOG4105CNA YD repeat protein E3166_RS21860 ENOG4105CS6 Rhs element vgr protein E3166_RS21865 ENOG4108WC9 type VI secretion system effector, hcp1 family E3166_RS21920 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E3166_RS21965 ENOG410600K aminopeptidase E3166_RS21975 ENOG4107RZZ dna polymerase iii epsilon subunit E3166_RS21985 ENOG4105D1A Methyltransferase E3166_RS21990 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E3166_RS21995 ENOG4105E9H Lytic Murein transglycosylase E3166_RS22000 ENOG4105F2W methyltransferase E3166_RS22010 ENOG4105HEI LysR family (Transcriptional regulator E3166_RS22015 ENOG4105CV8 reductase E3166_RS22050 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E3166_RS22055 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E3166_RS22060 ENOG4108UMI ABC transporter, permease E3166_RS22065 ENOG4105D01 (LipO)protein E3166_RS22070 ENOG4108R8X outer membrane lipoprotein E3166_RS22075 ENOG4108R96 Methyltransferase, YaeB family E3166_RS22085 ENOG4108UY0 (LipO)protein E3166_RS22090 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion E3166_RS22095 ENOG4108YZN class I peptide chain release factor E3166_RS22100 ENOG4108VWS Yaeq family E3166_RS22110 ENOG4105M1T rho-binding antiterminator E3166_RS22115 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E3166_RS22120 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase E3166_RS22125 ENOG4105CXN decarboxylase E3166_RS22135 ENOG4105C0B DNA polymerase III (alpha subunit) E3166_RS22160 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E3166_RS22165 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) E3166_RS22175 ENOG4105DZP Membrane-associated zinc metalloprotease E3166_RS22180 ENOG4105KNE Phosphatidate cytidylyltransferase E3166_RS22185 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E3166_RS22190 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) E3166_RS22215 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E3166_RS22235 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E3166_RS22240 ENOG4105C0H protease E3166_RS22255 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E3166_RS22260 ENOG4105EN6 Membrane E3166_RS22285 ENOG4105S6R Iron-hydroxamate transporter permease subunit E3166_RS22290 ENOG4105J76 Periplasmic binding protein E3166_RS22295 ENOG4105E0A ABC, transporter E3166_RS22305 ENOG4105BZ4 penicillin-binding protein E3166_RS22310 ENOG4105CQ7 ATP-dependent helicase E3166_RS22315 ENOG4107XID 2'-5' rna ligase E3166_RS22330 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E3166_RS22335 ENOG4105DJ0 Poly(A) Polymerase E3166_RS22340 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E3166_RS22350 ENOG4108VEV chaperone E3166_RS22355 ENOG4105CW0 outer membrane usher protein E3166_RS22360 ENOG4108XEY fimbrial-like adhesin protein E3166_RS22365 ENOG4105SYG Fimbrial protein E3166_RS22390 ENOG4108A32 Transposase E3166_RS22400 ENOG4107BJW polysaccharide deacetylase E3166_RS22405 ENOG4108YTN IIa component E3166_RS22410 ENOG4105E3A (ABC) transporter E3166_RS22415 ENOG4105DA5 (ABC) transporter E3166_RS22420 ENOG41077A9 carbonic anhydrase E3166_RS22425 ENOG4108UGV hypoxanthine phosphoribosyltransferase E3166_RS22430 ENOG4105DZG Dehydrogenase E3166_RS22435 ENOG4105E3B Multicopper oxidase E3166_RS22440 ENOG4108ZRK uncharacterized protein yacC E3166_RS22460 ENOG4107QIJ Aconitate hydratase 2 E3166_RS22465 ENOG4108NST exported protein E3166_RS22470 ENOG4107QN2 dihydrolipoyl dehydrogenase E3166_RS22475 ENOG4107QSN dihydrolipoamide acetyltransferase E3166_RS22480 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E3166_RS22485 ENOG41073TP transcriptional regulator E3166_RS22490 ENOG4105C85 amino acid E3166_RS22495 ENOG4106A72 regulatory protein AmpE E3166_RS22500 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E3166_RS22505 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E3166_RS22510 ENOG4108ZUW Major pilin subunit E3166_RS22515 ENOG4107QHF type ii secretion system protein e E3166_RS22520 ENOG4105D7Q type ii secretion system E3166_RS22530 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E3166_RS22545 ENOG4105M6F mutator MutT protein E3166_RS22565 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E3166_RS22570 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E3166_RS22575 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E3166_RS22580 ENOG4105CPF Cell wall formation (By similarity) E3166_RS22595 ENOG4105CNI cell division protein FtsW E3166_RS22600 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) E3166_RS22610 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E3166_RS22615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E3166_RS22620 ENOG4105CJN penicillin-binding protein E3166_RS22625 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E3166_RS22640 ENOG4107B7Y DNA-binding transcriptional regulator FruR E3166_RS22650 ENOG4108ZP8 Acetolactate synthase small subunit E3166_RS22655 ENOG4105C7K acetolactate synthase E3166_RS22660 ENOG41064T2 transcriptional regulator, lysR family E3166_RS22675 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E3166_RS22695 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E3166_RS22705 ENOG4105DP9 ABC transporter E3166_RS22710 ENOG4106SMU thiamine transporter membrane protein E3166_RS22715 ENOG4107T0D ABC, transporter E3166_RS22720 ENOG4108KF1 Membrane E3166_RS22725 ENOG41063TF transcriptional regulator (AraC E3166_RS22740 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E3166_RS22745 ENOG4105CQ2 DNA polymerase E3166_RS22750 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E3166_RS22755 ENOG4105D3G Pseudouridine synthase E3166_RS22770 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) E3166_RS22775 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E3166_RS22780 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E3166_RS22815 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) E3166_RS22830 ENOG4105C54 Major Facilitator superfamily E3166_RS22835 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein E3166_RS22840 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E3166_RS22875 ENOG4106YT9 Enoyl-CoA hydratase E3166_RS22885 ENOG4108XNW Transcriptional activatory protein CaiF E3166_RS22890 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E3166_RS22895 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E3166_RS22915 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E3166_RS22930 ENOG4105DTN riboflavin biosynthesis protein ribF E3166_RS22935 ENOG410647N response to DNA damage stimulus E3166_RS22955 ENOG4108MQF Chaperone E3166_RS22960 ENOG4105CW0 outer membrane usher protein E3166_RS22970 ENOG41063Z6 transcriptional regulator, lysR family E3166_RS22980 ENOG4105WI6 cell killing protein encoded within cryptic prophage E3166_RS23000 ENOG4108QUJ UPF0174 protein YaaW E3166_RS23005 ENOG4106HK8 GPR1 FUN34 yaaH family protein E3166_RS23010 ENOG4108RIR Molybdenum cofactor biosynthesis protein E3166_RS23015 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3166_RS23020 ENOG4105BZG amino acid carrier protein E3166_RS23030 ENOG41062C6 Protein of unknown function (DUF2502) E3166_RS23035 ENOG4105D98 threonine synthase E3166_RS23045 ENOG4105CFH Aspartokinase E3166_RS23055 ENOG4106FVC RNA methyltransferase E3166_RS23060 ENOG410759A E3166_RS23065 ENOG41065U4 response regulator E3166_RS23070 ENOG4105CT7 inner membrane cred family protein E3166_RS23075 ENOG4105EB3 Histidine kinase E3166_RS23080 ENOG4105E3W Two component transcriptional regulator (Winged helix family E3166_RS23085 ENOG4108RH0 Crea protein E3166_RS23090 ENOG4105UEI Transcriptional Regulator AraC Family E3166_RS23100 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E3166_RS23110 ENOG4107SC1 transglycosylase E3166_RS23115 ENOG4105C5H ABC transporter E3166_RS23125 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase E3166_RS23130 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E3166_RS23135 ENOG4105EAC phosphoserine phosphatase E3166_RS23140 ENOG41062Z9 Membrane E3166_RS23145 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) E3166_RS23180 ENOG41076CZ activating enzyme E3166_RS23185 ENOG4105EYA deoxyribonuclease E3166_RS23190 ENOG4108NRW Phospholipase, patatin family E3166_RS23200 ENOG4105K3G Periplasmic Protein E3166_RS23210 ENOG4105PAD Hydrolase E3166_RS23215 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E3166_RS23220 ENOG4108WPU DNA polymerase III subunit psi E3166_RS23235 ENOG4105YBH Protein of unknown function (DUF1435) E3166_RS23240 ENOG4108819 ferric iron reductase E3166_RS23245 ENOG4108T94 DNA-binding transcriptional activator BglJ E3166_RS23250 ENOG4108N8T regulatoR E3166_RS23255 ENOG4105DWK Membrane E3166_RS23270 ENOG4106CVF DNA replication protein E3166_RS23275 ENOG4105RI1 glycoprotein receptor E3166_RS23285 ENOG4105CPQ Dehydrogenase E3166_RS23290 ENOG410617M Transcriptional regulator E3166_RS23295 ENOG4108I5G Major Facilitator superfamily E3166_RS23300 ENOG4105C8Q Methyl-accepting chemotaxis E3166_RS23310 ENOG4105D22 carbon starvation protein E3166_RS23315 ENOG4105VCD cytoplasmic protein E3166_RS23320 ENOG4105CKI cobalamin synthesis protein E3166_RS23335 ENOG4108F3G Type I restriction-modification system, R subunit E3166_RS23345 ENOG4107QTH restriction modification system DNA specificity domain E3166_RS23365 ENOG4106DIZ Domain of unknown function (DUF1127) E3166_RS23370 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E3166_RS23380 ENOG4105DNE Transposase E3166_RS23385 ENOG41083G8 Multidrug resistance protein MdtM E3166_RS23390 ENOG4106BRA Membrane E3166_RS23395 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase E3166_RS23400 ENOG4105CIZ coA-substrate-specific enzyme activase E3166_RS23415 ENOG4108ZK4 sdia-regulated domain-containing protein E3166_RS23420 ENOG4105CBP Major Facilitator E3166_RS23435 ENOG41074DU domain protein E3166_RS23440 ENOG4108P2H Inner membrane protein YjiG E3166_RS23445 ENOG4105DYB Isoaspartyl dipeptidase E3166_RS23470 ENOG4105C6F GntR Family Transcriptional Regulator E3166_RS23475 ENOG4105DEI Mannitol dehydrogenase E3166_RS23485 ENOG4107EFN gluconate transport system permease 3 E3166_RS23490 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin E3166_RS23495 ENOG4108T65 Fimbrial E3166_RS23500 ENOG4108SQA Fimbrial E3166_RS23505 ENOG4105CW0 outer membrane usher protein E3166_RS23510 ENOG4108NAE Fimbrial chaperone protein E3166_RS23515 ENOG4108S54 Fimbrial protein E3166_RS23520 ENOG4108RQP Major type 1 subunit fimbrin E3166_RS23525 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off E3166_RS23530 ENOG4108W9T type 1 fimbriae regulatory protein E3166_RS23535 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria E3166_RS23540 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) E3166_RS23555 ENOG4105C4R Atp-dependent dna helicase E3166_RS23560 ENOG4108I5C dEAD DEAH box helicase E3166_RS23570 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E3166_RS23665 ENOG4105DQ4 alcohol dehydrogenase E3166_RS23670 ENOG4105D7A ATP-binding protein E3166_RS23675 ENOG4108K5H permease YjgP YjgQ family protein E3166_RS23680 ENOG4108M8S permease YjgP YjgQ family protein E3166_RS23690 ENOG4105MYG DNA polymerase iii, chi subunit E3166_RS23700 ENOG4108M3P Membrane E3166_RS23705 ENOG4108MJ3 acetyltransferase E3166_RS23710 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) E3166_RS23715 ENOG4105DBV ornithine carbamoyltransferase E3166_RS23725 ENOG4105XEP YhcH YjgK YiaL family protein E3166_RS23730 ENOG4108XFH Transcriptional regulator E3166_RS23735 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E3166_RS23740 ENOG4108UQ8 endoribonuclease L-psp E3166_RS23745 ENOG4107C93 pyrBI operon leader peptide E3166_RS23760 ENOG4105KME endoribonuclease L-psp E3166_RS23765 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E3166_RS23775 ENOG4105D4X repressor E3166_RS23780 ENOG4105C5Y PTS System E3166_RS23785 ENOG4105CG3 alpha amylase, catalytic region E3166_RS23790 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E3166_RS23795 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E3166_RS23805 ENOG4105CMS peptidase U62, modulator of DNA gyrase E3166_RS23815 ENOG4105DFU Cell wall formation (By similarity) E3166_RS23825 ENOG41062B0 ABC transporter, permease E3166_RS23830 ENOG4107R9N ABC transporter E3166_RS23835 ENOG4105C2J ABC transporter E3166_RS23840 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator E3166_RS23845 ENOG4105F0N pyrophosphate phospho-hydrolase E3166_RS23850 ENOG4105MZG transcriptional modulator of maze toxin, mazf E3166_RS23855 ENOG41087RY SpoVT_AbrB E3166_RS23860 ENOG4108ZHD aig2 family E3166_RS23865 ENOG4105MA0 exported protein E3166_RS23870 ENOG4105CFU surface antigen E3166_RS23880 ENOG4105C37 (CBS) domain E3166_RS23885 ENOG41061GZ Protein of unknown function (DUF1107) E3166_RS23890 ENOG4108UUE Transcriptional regulator E3166_RS23900 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E3166_RS23905 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E3166_RS23910 ENOG4105KVH Transcriptional regulator E3166_RS23915 ENOG4105ECR NmrA family E3166_RS23920 ENOG4105DXC membrane E3166_RS23930 ENOG4105C85 amino acid E3166_RS23935 ENOG4108V1T peptidylprolyl cis-trans isomerase E3166_RS23940 ENOG4105FHY Opacity-associated protein A E3166_RS23950 ENOG4105D7V transposase E3166_RS23955 ENOG4108RS6 transposase E3166_RS23975 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E3166_RS23990 ENOG4105KIT UPF0379 protein yjfY E3166_RS24010 ENOG4106ETB IIa component E3166_RS24015 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport E3166_RS24020 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E3166_RS24035 ENOG4108MXZ Esterase E3166_RS24040 ENOG4105WSB biofilm stress and motility protein A E3166_RS24045 ENOG4105S17 UPF0379 protein yjfN E3166_RS24050 ENOG4105CSU acyl-Coa dehydrogenase E3166_RS24055 ENOG4106032 Glutathionylspermidine synthase E3166_RS24060 ENOG4108KXT Conserved Protein E3166_RS24065 ENOG4105Z6B inner membrane protein yjfl E3166_RS24070 ENOG4107VNS Protein of unknown function (DUF2491) E3166_RS24075 ENOG4108P9J Phage shock protein A E3166_RS24080 ENOG4105FUX Conserved Protein E3166_RS24085 ENOG4105C2N RNA methyltransferase TrmH family group 3 E3166_RS24090 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E3166_RS24110 ENOG4105EPW hflc protein E3166_RS24115 ENOG4107QJR hflk protein E3166_RS24120 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E3166_RS24140 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E3166_RS24145 ENOG4105K8N protein family UPF0079, ATPase E3166_RS24150 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E3166_RS24180 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E3166_RS24195 ENOG4105EGS Mechanosensitive ion channel E3166_RS24200 ENOG4107SC7 Inner membrane transporter yjeM E3166_RS24210 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E3166_RS24215 ENOG4105E33 succinate dehydrogenase E3166_RS24230 ENOG41066YJ Beta-lactamase E3166_RS24235 ENOG4105QNF Outer membrane lipoprotein E3166_RS24240 ENOG4105KPY Small multidrug resistance protein E3166_RS24245 ENOG4106BSU Entericidin B E3166_RS24250 ENOG4107PEH Entericidin EcnA/B family E3166_RS24260 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E3166_RS24265 ENOG4105MTB Uncharacterized protein YjeJ E3166_RS24270 ENOG4108ZVF (LipO)protein E3166_RS24285 ENOG4105DVH amino acid E3166_RS24290 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 E3166_RS24295 ENOG4108IJ0 Aspartate ammonia-lyase E3166_RS24300 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E3166_RS24310 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E3166_RS24315 ENOG4108SIC Transcriptional regulator E3166_RS24325 ENOG4108M3R transcriptional activator CadC E3166_RS24330 ENOG4105D5Q Arginine ornithine antiporter E3166_RS24335 ENOG4105CXN decarboxylase E3166_RS24340 ENOG4105DUX Transporter E3166_RS24345 ENOG4105CRK lysyL-tRNA synthetase E3166_RS24360 ENOG410830R acetyltransferase E3166_RS24365 ENOG4105VR1 Pfam:DUF1271 E3166_RS24370 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E3166_RS24375 ENOG4108MRH transcriptional regulatory protein E3166_RS24380 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E3166_RS24385 ENOG4107GFK fumarate E3166_RS24390 ENOG4108R5S membrane E3166_RS24395 ENOG4105CT4 transporter E3166_RS24400 ENOG4105F8D glycoside hydrolase family 4 E3166_RS24405 ENOG4108K2B transcriptional regulator E3166_RS24410 ENOG4105CXN decarboxylase E3166_RS24415 ENOG4106ZGR Transcriptional regulator E3166_RS24420 ENOG4105D5Q Arginine ornithine antiporter E3166_RS24425 ENOG4105DIJ Phosphoethanolamine transferase E3166_RS24430 ENOG4105XJC Two component transcriptional regulator (Winged helix family E3166_RS24435 ENOG4105ECM Sensor protein basS pmrB E3166_RS24445 ENOG4105CSH Transporter E3166_RS24450 ENOG4108YIV E3166_RS24455 ENOG4108F5E vimentin E3166_RS24460 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E3166_RS24465 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase E3166_RS24470 ENOG4105D5T phosphonate abc transporter E3166_RS24475 ENOG4105EHI Phosphonate ABC transporter, periplasmic E3166_RS24485 ENOG4107RJJ Transcriptional regulator E3166_RS24490 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG E3166_RS24495 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH E3166_RS24500 ENOG4105EKV Phosphonate metabolism protein E3166_RS24505 ENOG4105FT8 Phosphonate metabolism E3166_RS24510 ENOG4105ENV phosphonate C-P lyase system protein PhnK E3166_RS24515 ENOG4105HRV phosphonate c-p lyase system protein phnl E3166_RS24520 ENOG4105FD8 phosphonate metabolism protein PhnM E3166_RS24525 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) E3166_RS24530 ENOG410849A acetyltransferase, (GNAT) family E3166_RS24535 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein E3166_RS24540 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 E3166_RS24550 ENOG4105C2J ABC transporter E3166_RS24555 ENOG4105CNN ABC, transporter E3166_RS24560 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E3166_RS24570 ENOG4105D2N Aldolase E3166_RS24585 ENOG4105EUZ Beta-lactamase domain protein E3166_RS24595 ENOG4105J12 Multidrug resistance protein mdtN E3166_RS24615 ENOG4105ETP RND efflux system, outer membrane lipoprotein E3166_RS24625 ENOG41082ND Uncharacterized protein yjcO E3166_RS24630 ENOG4105CK2 sodium dicarboxylate symporter E3166_RS24635 ENOG4108W0S formate-dependent nitrite reductase complex E3166_RS24645 ENOG4108QKW cytochrome c-type biogenesis protein E3166_RS24650 ENOG4105DVI reductase, NrfD E3166_RS24655 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E3166_RS24660 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit E3166_RS24670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E3166_RS24675 ENOG41062QD Membrane E3166_RS24690 ENOG4105EEQ Na H antiporter E3166_RS24695 ENOG4105C7N Xanthine uracil vitamin C permease E3166_RS24700 ENOG4108Z4X TRANSCRIPTIONal E3166_RS24705 ENOG4108W3Q Transcriptional regulator E3166_RS24710 ENOG4108M8H domain protein E3166_RS24715 ENOG4105PMV Membrane E3166_RS24720 ENOG4108UUM single-stranded DNA-binding protein E3166_RS24725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E3166_RS24730 ENOG4105MSB protein, conserved in bacteria E3166_RS24735 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme E3166_RS24740 ENOG4105F0S class B acid phosphatase E3166_RS24750 ENOG4105CGF Aromatic amino acid aminotransferase E3166_RS24755 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E3166_RS24760 ENOG4105CDU Replicative dna helicase E3166_RS24765 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E3166_RS24770 ENOG4105P4Z Phage shock protein G E3166_RS24775 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E3166_RS24785 ENOG4106FE3 DNA repair E3166_RS24815 ENOG4108X9F tail fiber protein E3166_RS24835 ENOG4108R7K Metal Dependent Phosphohydrolase E3166_RS24840 ENOG41077V0 CPS-53 (KpLE1) prophage E3166_RS24875 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E3166_RS24885 ENOG4105MYN Zinc uptake regulation protein E3166_RS24890 ENOG4105VDW Csbd family E3166_RS24895 ENOG4107R73 Mate efflux family protein E3166_RS24905 ENOG41080IJ Diacylglycerol kinase E3166_RS24930 ENOG4107W52 maltose operon periplasmic protein E3166_RS24940 ENOG4108IJ9 (ABC) transporter E3166_RS24945 ENOG4107FKK extracellular solute-binding protein family 1 E3166_RS24950 ENOG4105D56 permease protein E3166_RS24955 ENOG4105EG2 ABC transporter, permease E3166_RS24960 ENOG4107QNK )-transporter E3166_RS24980 ENOG4105E3R (LipO)protein E3166_RS24985 ENOG4108Q9C Periplasmic Protein E3166_RS24990 ENOG4108MDC (LipO)protein E3166_RS25000 ENOG4107QP8 phosphohexose isomerase E3166_RS25005 ENOG4105CFH Aspartokinase E3166_RS25010 ENOG4108ZR5 Conserved Protein E3166_RS25015 ENOG4105FE9 pseudouridine synthase E3166_RS25020 ENOG4105DKT Transcriptional regulator E3166_RS25025 ENOG4105CHR reductase E3166_RS25030 ENOG4108XCU pts system E3166_RS25035 ENOG4105KPI PTS system sorbose subfamily IIB component E3166_RS25040 ENOG4105ETZ PTS System E3166_RS25045 ENOG4105F3R pts system mannose fructose sorbose family iid E3166_RS25050 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein E3166_RS25060 ENOG4105EAM Na Pi-cotransporter E3166_RS25065 ENOG4105C3R Methionine synthase E3166_RS25070 ENOG41069M3 Transcriptional regulator E3166_RS25085 ENOG4108I9X Isocitrate lyase E3166_RS25090 ENOG4107QP3 malate synthase g E3166_RS25100 ENOG4105K5X acetyltransferase E3166_RS25130 ENOG4105C12 Phosphoribosylglycinamide synthetase E3166_RS25135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E3166_RS25140 ENOG4105BZU Histidine kinase E3166_RS25145 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism E3166_RS25150 ENOG4108T8B Protein of unknown function (DUF1481) E3166_RS25160 ENOG4105R2J Conserved Protein E3166_RS25195 ENOG4105D06 uba thif-type nad fad binding protein E3166_RS25200 ENOG4105WHD thiamine biosynthesis protein ThiS E3166_RS25205 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) E3166_RS25210 ENOG4105D41 biosynthesis protein thiH E3166_RS25215 ENOG410645W Thiamin biosynthesis protein ThiH E3166_RS25250 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E3166_RS25255 ENOG4105PM1 preprotein translocase subunit SecE E3166_RS25290 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase E3166_RS25295 ENOG4105D4A Cell wall formation (By similarity) E3166_RS25320 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E3166_RS25325 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) E3166_RS25330 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) E3166_RS25335 ENOG4108Y73 Membrane E3166_RS25340 ENOG4105EJ2 Transcriptional regulator E3166_RS25350 ENOG4105CH2 amidohydrolase E3166_RS25360 ENOG4105C5Q Transcriptional regulator E3166_RS25375 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase E3166_RS25390 ENOG4105DIJ Phosphoethanolamine transferase E3166_RS25395 ENOG4106R3P AraC family transcriptional regulator E3166_RS25400 ENOG4108XCZ PTS System E3166_RS25405 ENOG4108AHH pyruvate formate lyase II activase E3166_RS25415 ENOG4108YRF PTS System E3166_RS25420 ENOG4105DM4 PTS System E3166_RS25425 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E3166_RS25430 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3166_RS25435 ENOG4105DCT glycerol dehydrogenase E3166_RS25440 ENOG4108XC3 NADH ubiquinone oxidoreductase E3166_RS25445 ENOG4108Q5Y Membrane E3166_RS25455 ENOG4105SYT Methylenetetrahydrofolate reductase E3166_RS25460 ENOG4105CFH Aspartokinase E3166_RS25465 ENOG4105C28 cystathionine E3166_RS25475 ENOG4107S01 Repressor protein MetJ E3166_RS25490 ENOG4105CNA YD repeat protein E3166_RS25500 ENOG4105C25 Primosomal protein n' E3166_RS25505 ENOG4105ETE Transcriptional regulator (LacI family E3166_RS25510 ENOG41063M6 Cell Division Protein E3166_RS25525 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E3166_RS25550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E3166_RS25560 ENOG4105CBT Fructose-1,6-bisphosphatase E3166_RS25565 ENOG4105DP0 ferredoxin-NADP reductase E3166_RS25575 ENOG41065TG regulatoR E3166_RS25580 ENOG4108VTS Membrane E3166_RS25585 ENOG4105EBK exported protein E3166_RS25600 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E3166_RS25615 ENOG4105FMW periplasmic E3166_RS25620 ENOG4105E3W Two component transcriptional regulator (Winged helix family E3166_RS25625 ENOG4105E0F Histidine kinase E3166_RS25630 ENOG4108RPX mosc domain containing protein E3166_RS25640 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E3166_RS25650 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) E3166_RS25685 ENOG41064BA PTS system, fructose-specific, IIA component E3166_RS25690 ENOG4105DM4 PTS System E3166_RS25695 ENOG4105CN9 Peptidase m42 family protein E3166_RS25700 ENOG4106C3V frv operon regulatory protein E3166_RS25705 ENOG4108V87 frv operon regulatory protein E3166_RS25720 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E3166_RS25725 ENOG4108MG3 formate dehydrogenase E3166_RS25735 ENOG41068KX affects formate dehydrogenase-N E3166_RS25755 ENOG4105SUU thioesterase domain E3166_RS25770 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 E3166_RS25775 ENOG4105E98 transcriptional regulator DeoR family E3166_RS25780 ENOG4108MGF sugar kinase E3166_RS25785 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E3166_RS25790 ENOG4105D2M Aldolase E3166_RS25795 ENOG4107QKS N-acylglucosamine 2-epimerase E3166_RS25800 ENOG4107WI4 Aldose-1-epimerase E3166_RS25810 ENOG4105CJQ hydrolase, family 31 E3166_RS25815 ENOG4105CT4 transporter E3166_RS25820 ENOG4105CT4 transporter E3166_RS25825 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is E3166_RS25830 ENOG4105R9B Major Facilitator E3166_RS25840 ENOG4108K85 Transcriptional regulator E3166_RS25845 ENOG4105CI3 gtp-binding protein typa E3166_RS25850 ENOG4105C5F glutamine synthetase E3166_RS25855 ENOG4105CUX Signal transduction histidine kinase E3166_RS25860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E3166_RS25865 ENOG4106FIY E3166_RS25870 ENOG4105D4P Coproporphyrinogen iii oxidase E3166_RS25875 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) E3166_RS25885 ENOG4105C2M dna polymerase I E3166_RS25890 ENOG4106HNH Acyl-transferase E3166_RS25900 ENOG4108Z33 Thiol disulfide Interchange Protein E3166_RS25905 ENOG4105E27 serine threonine protein kinase E3166_RS25910 ENOG4105PC1 Conserved Protein E3166_RS25915 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E3166_RS25920 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b E3166_RS25950 ENOG4108RR8 protoporphyrinogen oxidase E3166_RS25955 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) E3166_RS25960 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E3166_RS25975 ENOG4105CHU acetyl-coa acetyltransferase E3166_RS25980 ENOG4108EX3 reductase E3166_RS25985 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E3166_RS25990 ENOG4105MDZ Transcriptional activator rfaH E3166_RS25995 ENOG4105F8V Hydrolase, tatD family E3166_RS26000 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E3166_RS26005 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) E3166_RS26010 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E3166_RS26020 ENOG4105JC1 sterol-binding domain protein E3166_RS26030 ENOG4105CGY Dna recombination protein E3166_RS26035 ENOG4108I5U Uridine phosphorylase E3166_RS26040 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) E3166_RS26050 ENOG4105DZ2 Transcriptional regulator E3166_RS26055 ENOG4105EMK carboxylate amino acid amine transporter E3166_RS26060 ENOG4105DQF Hydrolase E3166_RS26065 ENOG4108EUD Lysophospholipase E3166_RS26070 ENOG410829K Lysine exporter protein (Lyse ygga) E3166_RS26075 ENOG4105CCF Lysine exporter protein (Lyse ygga) E3166_RS26080 ENOG4105C9U ATP-dependent DNA helicase RecQ E3166_RS26085 ENOG4105HDD phospholipase E3166_RS26090 ENOG4108VUY thioesterase Superfamily protein E3166_RS26095 ENOG4105FR1 rard protein E3166_RS26105 ENOG4107QUT magnesium and cobalt transport protein CorA E3166_RS26120 ENOG4107QUT magnesium and cobalt transport protein CorA E3166_RS26125 ENOG4108T58 Mg2 transport protein CorA E3166_RS26130 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase E3166_RS26135 ENOG4105C4R Atp-dependent dna helicase E3166_RS26140 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant E3166_RS26150 ENOG4105CT0 Protein of unknown function, DUF484 E3166_RS26160 ENOG4105S7Z (LipO)protein E3166_RS26170 ENOG4107T0K Adenylate cyclase E3166_RS26180 ENOG41076E6 Uroporphyrinogen-III Synthase E3166_RS26185 ENOG4105ECF c-methyltransferase E3166_RS26190 ENOG410601J HemY protein E3166_RS26195 ENOG4105ENH Sulfatase E3166_RS26200 ENOG4105C4X radical SAM domain protein E3166_RS26230 ENOG4105C85 amino acid E3166_RS26250 ENOG4105EGZ biosynthesis protein E3166_RS26255 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E3166_RS26260 ENOG4108WJ1 acetyltransferase E3166_RS26265 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E3166_RS26270 ENOG4105C1B dTDP-glucose 4-6-dehydratase E3166_RS26275 ENOG4107QQG Dehydrogenase E3166_RS26280 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3166_RS26285 ENOG4105SFE lipopolysaccharide biosynthesis protein E3166_RS26290 ENOG4105ESV Glycosyl transferase, family 4 E3166_RS26295 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E3166_RS26320 ENOG4105C4R Atp-dependent dna helicase E3166_RS26330 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E3166_RS26340 ENOG4105EMY transcriptional regulator E3166_RS26345 ENOG4105C7B Threonine dehydratase E3166_RS26355 ENOG4105CM2 brancheD-chain amino acid aminotransferase E3166_RS26360 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit E3166_RS26385 ENOG4108WFC UPF0438 protein yifE E3166_RS26425 ENOG4107EJG GntR family transcriptional regulator E3166_RS26430 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3166_RS26435 ENOG4105ETE Transcriptional regulator (LacI family E3166_RS26440 ENOG4108RVA ribokinase E3166_RS26445 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E3166_RS26450 ENOG4105CNN ABC, transporter E3166_RS26455 ENOG4105C2J ABC transporter E3166_RS26460 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) E3166_RS26465 ENOG4105DFH Transport of potassium into the cell (By similarity) E3166_RS26475 ENOG4105EV2 VWA domain protein interacting with AAA ATPase E3166_RS26485 ENOG4108VVK transcriptional Regulator, AsnC E3166_RS26490 ENOG4105QTB Flavodoxin E3166_RS26525 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase E3166_RS26545 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E3166_RS26565 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E3166_RS26600 ENOG4108V42 Type IV secretion system protein VirB8 E3166_RS26715 ENOG4106CQM replication E3166_RS26750 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) E3166_RS26765 ENOG4105I1J Autotransporter E3166_RS26775 ENOG4108YXQ IS66 Orf2 family protein E3166_RS26780 ENOG4105E5H Transposase E3166_RS26790 ENOG4107BJW polysaccharide deacetylase E3166_RS26795 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) E3166_RS26800 ENOG4105DIJ Phosphoethanolamine transferase E3166_RS26805 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E3166_RS26820 ENOG4108MA4 Peptidase M66 E3166_RS26835 ENOG4107QHF type ii secretion system protein e E3166_RS26840 ENOG4105D7Q type ii secretion system E3166_RS26850 ENOG4105PBE general secretion pathway protein h E3166_RS26895 ENOG4108RC6 RTX toxin E3166_RS26900 ENOG4107V48 Hemolysin-type calcium-binding E3166_RS26905 ENOG4108JJA ABC, transporter E3166_RS26910 ENOG4105C42 Type I secretion membrane fusion protein (HlyD E3166_RS26930 ENOG4106JVB Replication Protein E3166_RS27000 ENOG41073YN Protein of unknown function (DUF1380) E3166_RS27070 ENOG4105FEQ ParB domain protein nuclease E3166_RS27120 ENOG4108N67 choline binding protein E3166_RS27150 ENOG4107U2T alpha beta E3166_RS27155 ENOG4107CBI conjugal transfer fertility inhibition protein E3166_RS27165 ENOG4105KK6 nuclease E3166_RS27180 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity)