locus-tag	class	description
E3166_RS00015	COG3312	ion transport
E3166_RS00065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3166_RS00090	COG3539	Fimbrial protein
E3166_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3166_RS00105	COG0573	inorganic phosphate transmembrane transporter activity
E3166_RS00110	COG0581	inorganic phosphate transmembrane transporter activity
E3166_RS00115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3166_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
E3166_RS00145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3166_RS00150	COG2252	PERMEase
E3166_RS00155	COG0431	NADPH-dependent FMN reductase
E3166_RS00160	COG2091	lysine biosynthetic process via aminoadipic acid
E3166_RS00175	COG0814	amino acid
E3166_RS00230	COG0592	DNA-directed DNA polymerase activity
E3166_RS00240	COG0187	DNA topoisomerase II activity
E3166_RS00245	COG3753	Protein conserved in bacteria
E3166_RS00250	COG0561	phosphatase activity
E3166_RS00260	COG0644	oxidoreductase
E3166_RS00265	COG0823	Involved in the tonB-independent uptake of proteins
E3166_RS00270	COG5645	(Lipo)protein
E3166_RS00290	COG2188	Transcriptional regulator
E3166_RS00305	COG2207	Transcriptional regulator
E3166_RS00310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3166_RS00315	COG3119	arylsulfatase activity
E3166_RS00325	COG2149	membrane
E3166_RS00335	COG0641	radical SAM
E3166_RS00340	COG2814	Major facilitator Superfamily
E3166_RS00355	COG0028	Belongs to the TPP enzyme family
E3166_RS00360	COG0440	acetolactate synthase activity
E3166_RS00380	COG2197	response regulator
E3166_RS00385	COG3851	Histidine kinase
E3166_RS00390	COG2271	Major facilitator Superfamily
E3166_RS00395	COG2271	Major facilitator Superfamily
E3166_RS00425	COG2814	Major facilitator Superfamily
E3166_RS00435	COG1464	Belongs to the NlpA lipoprotein family
E3166_RS00440	COG0697	spore germination
E3166_RS00445	COG2814	Major facilitator Superfamily
E3166_RS00610	COG5492	domain, Protein
E3166_RS00665	COG4372	Transposase
E3166_RS00670	COG3436	PFAM IS66 Orf2 family protein
E3166_RS00715	COG0582	viral genome integration into host DNA
E3166_RS00725	COG2211	Major facilitator Superfamily
E3166_RS00730	COG1501	Belongs to the glycosyl hydrolase 31 family
E3166_RS00735	COG2982	Protein involved in outer membrane biogenesis
E3166_RS00740	COG2233	PERMEase
E3166_RS00745	COG0786	glutamate:sodium symporter activity
E3166_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3166_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3166_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3166_RS00775	COG0194	GDP metabolic process
E3166_RS00785	COG2860	membrane
E3166_RS00790	COG3645	SOS response
E3166_RS00795	COG1561	YicC-like family, N-terminal region
E3166_RS00820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3166_RS00850	COG1519	Transferase
E3166_RS00855	COG0859	PFAM glycosyl transferase family 9
E3166_RS00860	COG0438	transferase activity, transferring glycosyl groups
E3166_RS00865	COG0515	serine threonine protein kinase
E3166_RS00875	COG3642	lipopolysaccharide core region biosynthetic process
E3166_RS00895	COG0859	PFAM glycosyl transferase family 9
E3166_RS00900	COG0859	PFAM glycosyl transferase family 9
E3166_RS00915	COG0156	8-amino-7-oxononanoate synthase activity
E3166_RS00925	COG1216	Glycosyl transferase, family 2
E3166_RS00930	COG2861	carbohydrate metabolic process
E3166_RS00935	COG4942	peptidase
E3166_RS00945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3166_RS00950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3166_RS00965	COG1045	serine acetyltransferase
E3166_RS00970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3166_RS00980	COG2186	Transcriptional regulator
E3166_RS00985	COG1620	l-lactate permease
E3166_RS00990	COG5295	Hep Hag repeat protein
E3166_RS01010	COG3722	fumarate hydratase activity
E3166_RS01020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS01020	COG2213	PTS system mannitol-specific
E3166_RS01030	COG1566	PFAM secretion protein HlyD family protein
E3166_RS01040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3166_RS01045	COG3209	COG3209 Rhs family protein
E3166_RS01050	COG0625	glutathione transferase activity
E3166_RS01060	COG3276	selenocysteine insertion sequence binding
E3166_RS01065	COG1454	alcohol dehydrogenase
E3166_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS01085	COG1566	PFAM secretion protein HlyD family protein
E3166_RS01090	COG0583	DNA-binding transcription factor activity
E3166_RS01095	COG3713	MltA-interacting MipA family protein
E3166_RS01105	COG2211	Major facilitator Superfamily
E3166_RS01115	COG1414	Transcriptional regulator
E3166_RS01120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS01125	COG3977	Valine--pyruvate aminotransferase
E3166_RS01130	COG0366	Alpha amylase catalytic
E3166_RS01135	COG2992	FlgJ-related protein
E3166_RS01140	COG2207	Transcriptional regulator
E3166_RS01140	COG1609	Transcriptional regulator
E3166_RS01145	COG4214	carbohydrate transport
E3166_RS01155	COG4213	ABC transporter substrate-binding protein
E3166_RS01165	COG1070	Carbohydrate kinase
E3166_RS01170	COG4682	membrane
E3166_RS01175	COG4682	membrane
E3166_RS01180	COG3274	enterobacterial common antigen metabolic process
E3166_RS01205	COG1278	Cold shock
E3166_RS01210	COG2944	sequence-specific DNA binding
E3166_RS01225	COG2885	chlorophyll binding
E3166_RS01230	COG0243	molybdopterin cofactor binding
E3166_RS01235	COG0456	acetyltransferase
E3166_RS01240	COG2818	Glycosylase
E3166_RS01245	COG5571	outer membrane autotransporter
E3166_RS01250	COG2223	nitrite transmembrane transporter activity
E3166_RS01255	COG3539	Fimbrial protein
E3166_RS01260	COG3121	Chaperone
E3166_RS01270	COG3539	Fimbrial protein
E3166_RS01275	COG3539	Fimbrial protein
E3166_RS01280	COG2194	sulfuric ester hydrolase activity
E3166_RS01290	COG0747	negative chemotaxis
E3166_RS01295	COG0601	transmembrane transport
E3166_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3166_RS01305	COG0444	Belongs to the ABC transporter superfamily
E3166_RS01310	COG4608	Belongs to the ABC transporter superfamily
E3166_RS01315	COG0814	amino acid
E3166_RS01325	COG2194	sulfuric ester hydrolase activity
E3166_RS01355	COG1215	transferase activity, transferring glycosyl groups
E3166_RS01360	COG1215	transferase activity, transferring glycosyl groups
E3166_RS01365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E3166_RS01370	COG3118	belongs to the thioredoxin family
E3166_RS01370	COG0457	Tetratricopeptide repeat
E3166_RS01375	COG2199	diguanylate cyclase activity
E3166_RS01375	COG2200	EAL domain
E3166_RS01385	COG0612	Peptidase, M16
E3166_RS01395	COG2200	EAL domain
E3166_RS01400	COG2982	Protein involved in outer membrane biogenesis
E3166_RS01405	COG0477	Major facilitator Superfamily
E3166_RS01410	COG1295	ribonuclease BN
E3166_RS01415	COG0583	DNA-binding transcription factor activity
E3166_RS01420	COG2197	response regulator
E3166_RS01430	COG1858	cytochrome C peroxidase
E3166_RS01435	COG0076	glutamate decarboxylase activity
E3166_RS01440	COG2207	Transcriptional regulator
E3166_RS01445	COG2207	Transcriptional regulator
E3166_RS01450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3166_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS01465	COG2771	luxR family
E3166_RS01470	COG3247	response to pH
E3166_RS01485	COG1285	pathogenesis
E3166_RS01490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E3166_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3166_RS01505	COG3721	Heme iron utilization protein
E3166_RS01515	COG4558	Periplasmic binding protein
E3166_RS01525	COG4771	TonB-dependent receptor
E3166_RS01530	COG3720	iron ion transport
E3166_RS01535	COG2197	response regulator
E3166_RS01540	COG3065	identical protein binding
E3166_RS01550	COG1393	Belongs to the ArsC family
E3166_RS01555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3166_RS01560	COG0640	Transcriptional regulator
E3166_RS01570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3166_RS01575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3166_RS01580	COG0339	signal peptide processing
E3166_RS01590	COG3104	oligopeptide transport
E3166_RS01595	COG0589	response to stress
E3166_RS01605	COG0306	phosphate transporter
E3166_RS01610	COG2081	HI0933 family
E3166_RS01635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS01640	COG1129	ABC transporter
E3166_RS01640	COG0842	Transport permease protein
E3166_RS01645	COG0842	Transport permease protein
E3166_RS01660	COG0191	fructose-bisphosphate aldolase activity
E3166_RS01675	COG3775	system Galactitol-specific IIC component
E3166_RS01680	COG3414	Phosphotransferase system galactitol-specific IIB component
E3166_RS01690	COG2188	Transcriptional regulator
E3166_RS01700	COG1124	(ABC) transporter
E3166_RS01705	COG0444	Belongs to the ABC transporter superfamily
E3166_RS01710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3166_RS01715	COG0601	transmembrane transport
E3166_RS01720	COG0747	negative chemotaxis
E3166_RS01725	COG2091	lysine biosynthetic process via aminoadipic acid
E3166_RS01730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3166_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS01745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3166_RS01770	COG1216	Glycosyl transferase, family 2
E3166_RS01790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3166_RS01800	COG0204	Acyl-transferase
E3166_RS01820	COG0628	permease
E3166_RS01835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3166_RS01850	COG3714	YhhN family
E3166_RS01860	COG3776	membrane
E3166_RS01865	COG0742	ribosomal rna small subunit methyltransferase
E3166_RS01870	COG0552	protein localization to endoplasmic reticulum
E3166_RS01875	COG2884	Cell division ATP-binding protein ftsE
E3166_RS01880	COG2177	Part of the ABC transporter FtsEX involved in
E3166_RS01885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3166_RS01890	COG0683	leucine binding
E3166_RS01905	COG0456	acetyltransferase
E3166_RS01910	COG0683	leucine binding
E3166_RS01915	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3166_RS01920	COG4177	L-phenylalanine transmembrane transporter activity
E3166_RS01925	COG0411	ABC transporter
E3166_RS01930	COG0410	ABC transporter
E3166_RS01940	COG1653	transport
E3166_RS01945	COG1175	transmembrane transport
E3166_RS01955	COG3842	ATPase activity
E3166_RS01960	COG0584	glycerophosphoryl diester phosphodiesterase
E3166_RS01970	COG0405	Gamma-glutamyltransferase
E3166_RS01980	COG1247	-acetyltransferase
E3166_RS01985	COG0673	inositol 2-dehydrogenase activity
E3166_RS01990	COG1741	Belongs to the pirin family
E3166_RS01995	COG1609	Transcriptional regulator
E3166_RS02000	COG3265	gluconokinase activity
E3166_RS02005	COG2610	gluconate transmembrane transporter activity
E3166_RS02010	COG0514	ATP-dependent DNA helicase (RecQ)
E3166_RS02030	COG2095	MarC family integral membrane protein
E3166_RS02035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3166_RS02040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3166_RS02060	COG0058	SHG alpha-glucan phosphorylase activity
E3166_RS02065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3166_RS02080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3166_RS02095	COG1349	DNA-binding transcription factor activity
E3166_RS02100	COG4650	regulator
E3166_RS02105	COG1690	Belongs to the RtcB family
E3166_RS02130	COG0058	SHG alpha-glucan phosphorylase activity
E3166_RS02135	COG1640	4-alpha-glucanotransferase
E3166_RS02140	COG2610	gluconate transmembrane transporter activity
E3166_RS02150	COG1040	competence protein
E3166_RS02160	COG5464	transposase or invertase
E3166_RS02170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E3166_RS02175	COG1918	ferrous iron import across plasma membrane
E3166_RS02180	COG2183	response to ionizing radiation
E3166_RS02185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3166_RS02190	COG0745	RESPONSE REGULATOR receiver
E3166_RS02195	COG2205	protein histidine kinase activity
E3166_RS02205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3166_RS02215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3166_RS02220	COG1011	Hydrolase
E3166_RS02230	COG0494	nUDIX hydrolase
E3166_RS02235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E3166_RS02240	COG4972	Pilus assembly protein
E3166_RS02245	COG3166	PFAM Fimbrial assembly family protein
E3166_RS02260	COG4796	Type ii and iii secretion system protein
E3166_RS02275	COG3266	domain, Protein
E3166_RS02280	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E3166_RS02285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3166_RS02290	COG0546	phosphoglycolate phosphatase activity
E3166_RS02295	COG0180	Tryptophanyl-tRNA synthetase
E3166_RS02300	COG2188	Transcriptional regulator
E3166_RS02310	COG1082	Xylose isomerase domain protein TIM barrel
E3166_RS02315	COG2222	sugar isomerase
E3166_RS02320	COG0531	amino acid
E3166_RS02335	COG2116	formate transmembrane transporter activity
E3166_RS02340	COG2146	nitrite reductase [NAD(P)H] activity
E3166_RS02345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3166_RS02355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3166_RS02365	COG2184	nucleotidyltransferase activity
E3166_RS02370	COG0512	Glutamine amidotransferase of anthranilate synthase
E3166_RS02375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3166_RS02380	COG1289	transmembrane transporter activity
E3166_RS02385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3166_RS02390	COG1765	OsmC-like protein
E3166_RS02395	COG3954	Phosphoribulokinase
E3166_RS02405	COG0429	hydrolase of the alpha beta-hydrolase fold
E3166_RS02410	COG0488	(ABC) transporter
E3166_RS02425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3166_RS02430	COG1047	Peptidyl-prolyl cis-trans
E3166_RS02440	COG0545	Peptidyl-prolyl cis-trans isomerase
E3166_RS02445	COG2964	Protein conserved in bacteria
E3166_RS02515	COG0089	rRNA binding
E3166_RS02605	COG0201	protein transport
E3166_RS02645	COG0789	Transcriptional regulator
E3166_RS02650	COG3036	rescue of stalled ribosome
E3166_RS02660	COG0569	domain protein
E3166_RS02680	COG0758	DNA mediated transformation
E3166_RS02690	COG0551	DNA topoisomerase type I activity
E3166_RS02695	COG0009	L-threonylcarbamoyladenylate synthase
E3166_RS02710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3166_RS02750	COG1126	abc transporter atp-binding protein
E3166_RS02755	COG0765	amino acid transport
E3166_RS02760	COG4597	amino acid ABC transporter
E3166_RS02765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS02785	COG1309	transcriptional regulator
E3166_RS02795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E3166_RS02805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3166_RS02815	COG4145	pantothenate transmembrane transporter activity
E3166_RS02820	COG3924	membrane
E3166_RS02825	COG0439	Biotin carboxylase
E3166_RS02830	COG0511	ligase activity, forming carbon-carbon bonds
E3166_RS02835	COG0604	alcohol dehydrogenase
E3166_RS02840	COG2200	EAL domain
E3166_RS02840	COG2199	diguanylate cyclase activity
E3166_RS02845	COG1077	Cell shape determining protein MreB Mrl
E3166_RS02850	COG1792	Involved in formation and maintenance of cell shape
E3166_RS02855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3166_RS02860	COG0424	maF-like protein
E3166_RS02865	COG1530	ribonuclease E activity
E3166_RS02870	COG3164	Protein of unknown function
E3166_RS02875	COG0312	modulator of DNA gyrase
E3166_RS02880	COG0583	DNA-binding transcription factor activity
E3166_RS02900	COG2732	(Barnase) inhibitor
E3166_RS02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3166_RS02925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3166_RS02930	COG3105	Protein conserved in bacteria
E3166_RS02935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3166_RS02950	COG0625	glutathione transferase activity
E3166_RS02955	COG2969	positive regulation of protein catabolic process
E3166_RS02960	COG3069	C4-dicarboxylate transmembrane transporter activity
E3166_RS02990	COG2731	YhcH YjgK YiaL family protein
E3166_RS02995	COG4804	nuclease activity
E3166_RS03000	COG0493	'glutamate synthase
E3166_RS03005	COG0069	glutamate synthase activity
E3166_RS03005	COG0070	glutamate synthase
E3166_RS03005	COG0067	glutamate synthase
E3166_RS03010	COG1242	4 iron, 4 sulfur cluster binding
E3166_RS03015	COG5002	protein histidine kinase activity
E3166_RS03015	COG0784	Response regulator, receiver
E3166_RS03015	COG2198	Histidine kinase
E3166_RS03020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3166_RS03030	COG0515	serine threonine protein kinase
E3166_RS03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS03050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3166_RS03055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3166_RS03060	COG1137	ATPase activity
E3166_RS03065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3166_RS03070	COG3117	lipopolysaccharide transmembrane transporter activity
E3166_RS03075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3166_RS03080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3166_RS03080	COG0517	IMP dehydrogenase activity
E3166_RS03085	COG0530	calcium, potassium:sodium antiporter activity
E3166_RS03090	COG1127	ABC transporter
E3166_RS03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3166_RS03100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3166_RS03105	COG2854	intermembrane phospholipid transfer
E3166_RS03110	COG3113	response to antibiotic
E3166_RS03115	COG5007	Belongs to the BolA IbaG family
E3166_RS03125	COG3423	Transcriptional regulator
E3166_RS03130	COG0142	geranyltranstransferase activity
E3166_RS03145	COG0697	spore germination
E3166_RS03155	COG2027	D-alanyl-D-alanine carboxypeptidase
E3166_RS03160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3166_RS03165	COG1534	Rna-binding protein
E3166_RS03175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3166_RS03180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3166_RS03190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3166_RS03200	COG2194	sulfuric ester hydrolase activity
E3166_RS03220	COG0195	Participates in both transcription termination and antitermination
E3166_RS03260	COG0513	Belongs to the DEAD box helicase family
E3166_RS03265	COG0814	amino acid
E3166_RS03270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3166_RS03275	COG0826	peptidase U32
E3166_RS03280	COG0826	peptidase U32
E3166_RS03285	COG3154	lipid carrier protein
E3166_RS03290	COG3153	acetyltransferase
E3166_RS03300	COG3787	Belongs to the UPF0306 family
E3166_RS03305	COG0693	protein deglycase activity
E3166_RS03310	COG0702	epimerase
E3166_RS03315	COG0701	Predicted permease
E3166_RS03320	COG2823	Periplasmic or secreted lipoprotein
E3166_RS03340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3166_RS03360	COG3188	usher protein
E3166_RS03365	COG3121	Chaperone
E3166_RS03370	COG3539	Fimbrial protein
E3166_RS03380	COG3716	PTS system mannose fructose sorbose family IID component
E3166_RS03390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS03400	COG2222	sugar isomerase
E3166_RS03405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3166_RS03410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS03415	COG3716	PTS system mannose fructose sorbose family IID component
E3166_RS03425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS03435	COG1349	DNA-binding transcription factor activity
E3166_RS03445	COG2002	toxin-antitoxin pair type II binding
E3166_RS03450	COG2721	sulfolactate sulfo-lyase activity
E3166_RS03455	COG2271	Major facilitator Superfamily
E3166_RS03465	COG2084	Dehydrogenase
E3166_RS03470	COG1929	Belongs to the glycerate kinase type-1 family
E3166_RS03495	COG0583	DNA-binding transcription factor activity
E3166_RS03500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3166_RS03510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3166_RS03515	COG1882	Formate acetyltransferase
E3166_RS03520	COG0251	oxidation-reduction process
E3166_RS03525	COG1760	l-serine dehydratase
E3166_RS03530	COG0814	amino acid
E3166_RS03545	COG1741	Belongs to the pirin family
E3166_RS03550	COG0583	DNA-binding transcription factor activity
E3166_RS03555	COG3152	Membrane
E3166_RS03560	COG3152	Membrane
E3166_RS03565	COG0435	Glutathione S-transferase
E3166_RS03570	COG2259	Doxx family
E3166_RS03580	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E3166_RS03585	COG4575	ribosome binding
E3166_RS03590	COG1422	Protein of unknown function (DUF1090)
E3166_RS03600	COG0586	Pfam SNARE associated Golgi protein
E3166_RS03605	COG2186	Transcriptional regulator
E3166_RS03610	COG2271	Major facilitator Superfamily
E3166_RS03620	COG2721	sulfolactate sulfo-lyase activity
E3166_RS03630	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E3166_RS03635	COG0861	Integral membrane protein TerC family
E3166_RS03640	COG0673	inositol 2-dehydrogenase activity
E3166_RS03645	COG2949	membrane
E3166_RS03650	COG1451	nucleotide metabolic process
E3166_RS03660	COG4680	protein conserved in bacteria
E3166_RS03665	COG5499	transcription regulator containing HTH domain
E3166_RS03670	COG1902	pentaerythritol trinitrate reductase activity
E3166_RS03670	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3166_RS03675	COG3408	Glycogen debranching enzyme
E3166_RS03675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E3166_RS03685	COG0531	amino acid
E3166_RS03690	COG2731	YhcH YjgK YiaL family protein
E3166_RS03695	COG3250	beta-galactosidase activity
E3166_RS03700	COG1609	Transcriptional regulator
E3166_RS03705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3166_RS03715	COG0840	transmembrane signaling receptor activity
E3166_RS03720	COG1695	Transcriptional regulator
E3166_RS03725	COG2375	cellular response to nickel ion
E3166_RS03740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3166_RS03745	COG0358	DNA primase activity
E3166_RS03750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3166_RS03760	COG0471	metal ion transport
E3166_RS03765	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS03770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS03775	COG0583	DNA-binding transcription factor activity
E3166_RS03785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3166_RS03800	COG4991	sh3 domain protein
E3166_RS03805	COG3025	triphosphatase activity
E3166_RS03830	COG2268	Band 7 protein
E3166_RS03835	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3166_RS03865	COG3384	dioxygenase
E3166_RS03870	COG0754	glutathionylspermidine amidase activity
E3166_RS03880	COG1538	Outer membrane efflux protein
E3166_RS03885	COG0494	nUDIX hydrolase
E3166_RS03890	COG3151	Protein conserved in bacteria
E3166_RS03895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3166_RS03900	COG3150	esterase
E3166_RS03905	COG0187	DNA topoisomerase II activity
E3166_RS03910	COG4774	siderophore transport
E3166_RS03915	COG1120	ATPase activity
E3166_RS03920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3166_RS03925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3166_RS03935	COG1737	Transcriptional regulator
E3166_RS03940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3166_RS03945	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3166_RS03950	COG0642	Histidine kinase
E3166_RS03955	COG0745	RESPONSE REGULATOR receiver
E3166_RS03960	COG3111	PFAM Bacterial OB fold (BOF) protein
E3166_RS03965	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3166_RS03970	COG4166	transmembrane transport
E3166_RS03975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3166_RS03980	COG0204	Acyl-transferase
E3166_RS03985	COG2132	Multicopper oxidase
E3166_RS03990	COG1032	radical SAM domain protein
E3166_RS03995	COG4238	major outer membrane lipoprotein
E3166_RS04005	COG0656	L-ascorbic acid biosynthetic process
E3166_RS04010	COG1979	alcohol dehydrogenase
E3166_RS04015	COG2207	Transcriptional regulator
E3166_RS04020	COG0586	Pfam SNARE associated Golgi protein
E3166_RS04025	COG0626	cystathionine gamma-synthase activity
E3166_RS04030	COG0811	peptide transport
E3166_RS04035	COG0848	biopolymer transport protein
E3166_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS04050	COG0667	Aldo Keto reductase
E3166_RS04065	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3166_RS04070	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS04075	COG5557	Pfam Polysulphide reductase, NrfD
E3166_RS04080	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3166_RS04085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3166_RS04090	COG1773	rubredoxin
E3166_RS04095	COG0375	protein maturation
E3166_RS04100	COG0298	carbon dioxide binding
E3166_RS04105	COG0625	glutathione transferase activity
E3166_RS04110	COG0754	glutathionylspermidine amidase activity
E3166_RS04135	COG3436	PFAM IS66 Orf2 family protein
E3166_RS04140	COG4372	Transposase
E3166_RS04145	COG3436	PFAM IS66 Orf2 family protein
E3166_RS04210	COG3436	PFAM IS66 Orf2 family protein
E3166_RS04225	COG0582	viral genome integration into host DNA
E3166_RS04235	COG1811	Na channel or pump
E3166_RS04240	COG1982	Orn Lys Arg decarboxylase major
E3166_RS04245	COG2211	Major facilitator Superfamily
E3166_RS04260	COG1194	a g-specific adenine glycosylase
E3166_RS04270	COG3171	Protein conserved in bacteria
E3166_RS04280	COG0252	asparaginase activity
E3166_RS04290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3166_RS04295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3166_RS04305	COG0762	integral membrane protein
E3166_RS04310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3166_RS04315	COG2805	Type II/IV secretion system protein
E3166_RS04330	COG0189	ligase activity
E3166_RS04335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3166_RS04340	COG2356	endonuclease I
E3166_RS04345	COG3091	SprT-like family
E3166_RS04350	COG2814	Major facilitator Superfamily
E3166_RS04370	COG1166	arginine decarboxylase activity
E3166_RS04385	COG0501	Belongs to the peptidase M48B family
E3166_RS04390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3166_RS04395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS04400	COG2213	PTS system mannitol-specific
E3166_RS04405	COG1063	alcohol dehydrogenase
E3166_RS04410	COG1494	fructose-1,6-bisphosphatase
E3166_RS04420	COG1072	(Pantothenic acid kinase))
E3166_RS04425	COG1122	ATPase activity
E3166_RS04430	COG1122	ATPase activity
E3166_RS04455	COG0126	phosphoglycerate kinase activity
E3166_RS04460	COG0191	fructose-bisphosphate aldolase activity
E3166_RS04465	COG0668	transmembrane transport
E3166_RS04475	COG2968	Membrane
E3166_RS04485	COG0427	acetyl-CoA hydrolase
E3166_RS04490	COG1024	Enoyl-CoA hydratase
E3166_RS04495	COG1703	isobutyryl-CoA mutase activity
E3166_RS04500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3166_RS04500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3166_RS04515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3166_RS04530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3166_RS04550	COG0006	proline dipeptidase activity
E3166_RS04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3166_RS04560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3166_RS04585	COG2723	6-phospho-beta-galactosidase activity
E3166_RS04595	COG1272	protein, Hemolysin III
E3166_RS04605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3166_RS04615	COG0716	FMN binding
E3166_RS04620	COG4974	Belongs to the 'phage' integrase family
E3166_RS04625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3166_RS04630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3166_RS04640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3166_RS04660	COG2233	PERMEase
E3166_RS04675	COG2252	PERMEase
E3166_RS04680	COG0402	S-adenosylhomocysteine deaminase activity
E3166_RS04685	COG2233	PERMEase
E3166_RS04690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3166_RS04690	COG2080	2 iron, 2 sulfur cluster binding
E3166_RS04695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3166_RS04705	COG0493	'glutamate synthase
E3166_RS04705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS04710	COG2068	MobA-Related Protein
E3166_RS04715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3166_RS04720	COG3608	succinylglutamate desuccinylase aspartoacylase
E3166_RS04720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3166_RS04725	COG0549	Belongs to the carbamate kinase family
E3166_RS04735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3166_RS04740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3166_RS04745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3166_RS04755	COG2080	2 iron, 2 sulfur cluster binding
E3166_RS04760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3166_RS04765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3166_RS04770	COG4942	peptidase
E3166_RS04790	COG2207	Transcriptional regulator
E3166_RS04895	COG2197	response regulator
E3166_RS04900	COG0741	lytic transglycosylase activity
E3166_RS04910	COG0457	Tetratricopeptide repeat
E3166_RS04910	COG3710	Transcriptional regulator
E3166_RS04915	COG0457	Tetratricopeptide repeat
E3166_RS04940	COG3710	Transcriptional regulator
E3166_RS04945	COG2771	luxR family
E3166_RS04950	COG0814	amino acid
E3166_RS04955	COG0183	Belongs to the thiolase family
E3166_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS04970	COG2814	Major facilitator Superfamily
E3166_RS04975	COG1794	racemase activity, acting on amino acids and derivatives
E3166_RS04980	COG0583	DNA-binding transcription factor activity
E3166_RS04990	COG1609	Transcriptional regulator
E3166_RS05005	COG0667	Aldo Keto reductase
E3166_RS05015	COG0861	Integral membrane protein TerC family
E3166_RS05030	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E3166_RS05045	COG2165	general secretion pathway protein
E3166_RS05050	COG4795	General secretion pathway protein
E3166_RS05060	COG4967	type IV pilus modification protein PilV
E3166_RS05065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3166_RS05070	COG1025	Belongs to the peptidase M16 family
E3166_RS05075	COG1074	ATP-dependent DNA helicase activity
E3166_RS05080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3166_RS05085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3166_RS05085	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3166_RS05090	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3166_RS05110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E3166_RS05115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3166_RS05120	COG2166	iron-sulfur cluster assembly
E3166_RS05125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3166_RS05135	COG0583	DNA-binding transcription factor activity
E3166_RS05140	COG2363	Small membrane protein
E3166_RS05150	COG1349	DNA-binding transcription factor activity
E3166_RS05160	COG1070	Carbohydrate kinase
E3166_RS05170	COG0738	Major facilitator superfamily
E3166_RS05175	COG0235	Class ii aldolase
E3166_RS05180	COG1454	alcohol dehydrogenase
E3166_RS05190	COG1760	l-serine dehydratase
E3166_RS05195	COG0814	amino acid
E3166_RS05200	COG1611	Belongs to the LOG family
E3166_RS05215	COG3098	single-species biofilm formation
E3166_RS05220	COG0564	pseudouridine synthase activity
E3166_RS05225	COG0716	FMN binding
E3166_RS05230	COG2271	Major facilitator Superfamily
E3166_RS05240	COG4948	Mandelate Racemase Muconate Lactonizing
E3166_RS05245	COG2205	protein histidine kinase activity
E3166_RS05245	COG3437	response regulator, receiver
E3166_RS05245	COG4999	Histidine kinase
E3166_RS05245	COG3850	Histidine kinase
E3166_RS05250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3166_RS05255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3166_RS05260	COG2336	PFAM SpoVT AbrB
E3166_RS05265	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3166_RS05270	COG3956	TIGRFAM MazG family protein
E3166_RS05285	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3166_RS05295	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3166_RS05305	COG0602	queuosine metabolic process
E3166_RS05310	COG1070	Carbohydrate kinase
E3166_RS05315	COG2223	nitrite transmembrane transporter activity
E3166_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS05325	COG0277	FAD linked oxidase domain protein
E3166_RS05335	COG2086	electron transfer activity
E3166_RS05345	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3166_RS05350	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3166_RS05360	COG0720	synthase
E3166_RS05365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3166_RS05390	COG1857	crispr-associated protein
E3166_RS05405	COG1518	maintenance of DNA repeat elements
E3166_RS05410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS05415	COG2234	aminopeptidase activity
E3166_RS05470	COG1388	LysM domain
E3166_RS05470	COG4942	peptidase
E3166_RS05475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3166_RS05480	COG1846	Transcriptional regulator
E3166_RS05485	COG0163	prenyltransferase activity
E3166_RS05490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3166_RS05500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3166_RS05520	COG3604	Transcriptional regulator
E3166_RS05525	COG0309	Hydrogenase expression formation protein (HypE)
E3166_RS05530	COG0409	Hydrogenase expression formation protein
E3166_RS05535	COG0298	carbon dioxide binding
E3166_RS05540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E3166_RS05545	COG0375	protein maturation
E3166_RS05555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS05560	COG0651	ATP synthesis coupled electron transport
E3166_RS05565	COG0650	Formate hydrogenlyase subunit 4
E3166_RS05570	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3166_RS05570	COG3261	NADH dehydrogenase
E3166_RS05575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3166_RS05580	COG3260	NADH ubiquinone oxidoreductase 20
E3166_RS05590	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3166_RS05595	COG2723	6-phospho-beta-galactosidase activity
E3166_RS05600	COG1263	PTS System
E3166_RS05600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS05605	COG1609	Transcriptional regulator
E3166_RS05610	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS05615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E3166_RS05635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3166_RS05635	COG0517	IMP dehydrogenase activity
E3166_RS05640	COG1349	DNA-binding transcription factor activity
E3166_RS05645	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS05665	COG3730	PTS system glucitol sorbitol-specific
E3166_RS05670	COG2951	lytic endotransglycosylase activity
E3166_RS05675	COG1546	Belongs to the CinA family
E3166_RS05690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3166_RS05695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3166_RS05725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3166_RS05730	COG1238	metal cluster binding
E3166_RS05745	COG2814	Major facilitator Superfamily
E3166_RS05750	COG1566	PFAM secretion protein HlyD family protein
E3166_RS05755	COG1846	Transcriptional regulator
E3166_RS05765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E3166_RS05770	COG2814	Major facilitator Superfamily
E3166_RS05775	COG2113	Glycine betaine
E3166_RS05780	COG4176	ABC-type proline glycine betaine transport system permease component
E3166_RS05785	COG4175	Glycine betaine
E3166_RS05790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3166_RS05795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3166_RS05805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3166_RS05810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3166_RS05820	COG4575	ribosome binding
E3166_RS05835	COG2916	Histone family protein nucleoid-structuring protein H-NS
E3166_RS05840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3166_RS05845	COG0640	Transcriptional regulator
E3166_RS05850	COG0401	homolog of Blt101
E3166_RS05855	COG1652	LysM domain
E3166_RS05860	COG1802	Transcriptional regulator
E3166_RS05865	COG1113	amino acid transport
E3166_RS05870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3166_RS05875	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS05880	COG0579	oxidoreductase
E3166_RS05915	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS06020	COG2867	negative regulation of translational initiation
E3166_RS06030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3166_RS06035	COG0497	DNA recombination
E3166_RS06050	COG4536	flavin adenine dinucleotide binding
E3166_RS06055	COG4137	Cytochrome C assembly protein
E3166_RS06060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3166_RS06085	COG2885	chlorophyll binding
E3166_RS06090	COG2199	diguanylate cyclase activity
E3166_RS06105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3166_RS06110	COG0287	Prephenate dehydrogenase
E3166_RS06110	COG1605	Chorismate mutase
E3166_RS06115	COG0077	Prephenate dehydratase
E3166_RS06115	COG1605	Chorismate mutase
E3166_RS06125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3166_RS06130	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3166_RS06135	COG0564	pseudouridine synthase activity
E3166_RS06145	COG0542	response to heat
E3166_RS06170	COG0477	Major facilitator Superfamily
E3166_RS06175	COG5544	Lipoprotein
E3166_RS06180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3166_RS06185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3166_RS06185	COG1042	CoA-binding domain protein
E3166_RS06185	COG0045	succinate-CoA ligase (ADP-forming) activity
E3166_RS06195	COG3118	belongs to the thioredoxin family
E3166_RS06200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3166_RS06215	COG1280	lysine exporter protein (LysE YggA)
E3166_RS06220	COG0583	DNA-binding transcription factor activity
E3166_RS06225	COG0513	Belongs to the DEAD box helicase family
E3166_RS06230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3166_RS06235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3166_RS06245	COG1595	DNA-templated transcription, initiation
E3166_RS06250	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E3166_RS06255	COG3026	antisigma factor binding
E3166_RS06260	COG3086	response to oxidative stress
E3166_RS06270	COG0681	Belongs to the peptidase S26 family
E3166_RS06290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3166_RS06305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS06310	COG1737	Transcriptional regulator
E3166_RS06315	COG0560	Phosphoserine phosphatase
E3166_RS06320	COG0590	tRNA wobble adenosine to inosine editing
E3166_RS06325	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3166_RS06330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3166_RS06330	COG0047	phosphoribosylformylglycinamidine synthase activity
E3166_RS06335	COG2205	protein histidine kinase activity
E3166_RS06340	COG3170	Tfp pilus assembly protein FimV
E3166_RS06345	COG2204	response regulator
E3166_RS06350	COG0347	Belongs to the P(II) protein family
E3166_RS06355	COG1017	nitric oxide dioxygenase activity
E3166_RS06355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3166_RS06365	COG1940	carbohydrate kinase activity
E3166_RS06370	COG0457	Tetratricopeptide repeat
E3166_RS06375	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS06380	COG1129	ABC transporter
E3166_RS06385	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS06390	COG1063	alcohol dehydrogenase
E3166_RS06395	COG1063	alcohol dehydrogenase
E3166_RS06400	COG2017	converts alpha-aldose to the beta-anomer
E3166_RS06405	COG2259	Doxx family
E3166_RS06430	COG4638	Rieske (2fe-2S)
E3166_RS06435	COG0583	DNA-binding transcription factor activity
E3166_RS06440	COG2814	Major facilitator Superfamily
E3166_RS06445	COG3711	transcriptional antiterminator
E3166_RS06450	COG1073	alpha beta
E3166_RS06455	COG0483	inositol monophosphate 1-phosphatase activity
E3166_RS06475	COG0822	iron-sulfur transferase activity
E3166_RS06495	COG0633	Ferredoxin
E3166_RS06500	COG2975	iron-sulfur cluster assembly
E3166_RS06515	COG2897	thiosulfate sulfurtransferase activity
E3166_RS06520	COG2373	Large extracellular alpha-helical protein
E3166_RS06525	COG4953	penicillin-binding protein 1C
E3166_RS06530	COG0243	molybdopterin cofactor binding
E3166_RS06535	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS06540	COG3302	dmso reductase anchor subunit
E3166_RS06575	COG2976	Protein conserved in bacteria
E3166_RS06590	COG1645	bacterial-type flagellum-dependent swarming motility
E3166_RS06600	COG0516	GMP reductase activity
E3166_RS06600	COG0517	IMP dehydrogenase activity
E3166_RS06615	COG3133	Outer membrane lipoprotein
E3166_RS06630	COG2200	EAL domain
E3166_RS06635	COG0248	Ppx GppA phosphatase
E3166_RS06640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3166_RS06645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3166_RS06660	COG2233	PERMEase
E3166_RS06670	COG1393	Belongs to the ArsC family
E3166_RS06675	COG4783	chaperone-mediated protein folding
E3166_RS06680	COG0628	permease
E3166_RS06685	COG2116	formate transmembrane transporter activity
E3166_RS06690	COG3604	Transcriptional regulator
E3166_RS06700	COG3260	NADH ubiquinone oxidoreductase 20
E3166_RS06705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3166_RS06710	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E3166_RS06710	COG3261	NADH dehydrogenase
E3166_RS06715	COG0651	ATP synthesis coupled electron transport
E3166_RS06720	COG4237	Hydrogenase 4 membrane
E3166_RS06725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3166_RS06730	COG0650	Formate hydrogenlyase subunit 4
E3166_RS06735	COG0651	ATP synthesis coupled electron transport
E3166_RS06740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS06745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3166_RS06750	COG2716	regulation of RNA biosynthetic process
E3166_RS06760	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3166_RS06770	COG2321	neutral zinc metallopeptidase
E3166_RS06780	COG0400	carboxylic ester hydrolase activity
E3166_RS06795	COG1393	Belongs to the ArsC family
E3166_RS06805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3166_RS06810	COG3850	Histidine kinase
E3166_RS06815	COG0493	'glutamate synthase
E3166_RS06815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS06825	COG5342	invasion associated locus B
E3166_RS06830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3166_RS06835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3166_RS06840	COG0280	phosphate acetyltransferase
E3166_RS06840	COG0281	malic enzyme
E3166_RS06845	COG4810	utilization protein
E3166_RS06850	COG4917	ethanolamine utilization protein
E3166_RS06855	COG4766	ethanolamine catabolic process
E3166_RS06860	COG4812	Cobalamin adenosyltransferase
E3166_RS06865	COG0280	phosphate acetyltransferase
E3166_RS06870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E3166_RS06875	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E3166_RS06880	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS06885	COG4820	ethanolamine utilization protein (EutJ)
E3166_RS06890	COG1454	alcohol dehydrogenase
E3166_RS06895	COG3192	ethanolamine utilization protein
E3166_RS06900	COG4819	ethanolamine utilization protein
E3166_RS06905	COG4303	Ethanolamine ammonia lyase large subunit
E3166_RS06915	COG4816	utilization protein
E3166_RS06920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E3166_RS06925	COG2207	Transcriptional regulator
E3166_RS06935	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3166_RS06955	COG2837	iron assimilation
E3166_RS06960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3166_RS06965	COG1263	PTS System
E3166_RS06965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS06985	COG4150	thiosulfate binding
E3166_RS06990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3166_RS06995	COG4208	sulfate ABC transporter
E3166_RS07000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3166_RS07005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3166_RS07020	COG2190	(PTS) system
E3166_RS07025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3166_RS07030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS07035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3166_RS07055	COG3530	Putative quorum-sensing-regulated virulence factor
E3166_RS07060	COG0385	Bile acid
E3166_RS07065	COG0583	DNA-binding transcription factor activity
E3166_RS07105	COG0675	Transposase, IS605 OrfB family
E3166_RS07110	COG3415	Transposase
E3166_RS07115	COG3415	Transposase
E3166_RS07130	COG2199	diguanylate cyclase activity
E3166_RS07130	COG2200	EAL domain
E3166_RS07135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3166_RS07160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS07165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS07170	COG0006	proline dipeptidase activity
E3166_RS07175	COG1363	Peptidase, m42
E3166_RS07180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS07180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3166_RS07180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS07185	COG2207	Transcriptional regulator
E3166_RS07190	COG3279	Response regulator of the LytR AlgR family
E3166_RS07195	COG3275	phosphorelay sensor kinase activity
E3166_RS07200	COG0436	Aminotransferase
E3166_RS07210	COG1560	Kdo2-lipid A biosynthetic process
E3166_RS07235	COG0028	Belongs to the TPP enzyme family
E3166_RS07240	COG0679	Auxin Efflux Carrier
E3166_RS07245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3166_RS07250	COG2205	protein histidine kinase activity
E3166_RS07250	COG2198	Histidine kinase
E3166_RS07250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS07250	COG0784	Response regulator, receiver
E3166_RS07255	COG2197	response regulator
E3166_RS07260	COG1566	PFAM secretion protein HlyD family protein
E3166_RS07265	COG0477	Major facilitator Superfamily
E3166_RS07355	COG0582	viral genome integration into host DNA
E3166_RS07365	COG2116	formate transmembrane transporter activity
E3166_RS07370	COG2853	Lipoprotein
E3166_RS07380	COG2067	long-chain fatty acid transport protein
E3166_RS07385	COG3691	Protein conserved in bacteria
E3166_RS07400	COG2062	phosphohistidine phosphatase, SixA
E3166_RS07405	COG3539	Fimbrial protein
E3166_RS07410	COG3188	usher protein
E3166_RS07415	COG3121	Chaperone
E3166_RS07420	COG3539	Fimbrial protein
E3166_RS07425	COG3539	Fimbrial protein
E3166_RS07430	COG3539	Fimbrial protein
E3166_RS07460	COG0730	response to heat
E3166_RS07465	COG3101	peptidyl-lysine hydroxylation
E3166_RS07475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3166_RS07475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3166_RS07480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3166_RS07485	COG2814	Major facilitator Superfamily
E3166_RS07500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3166_RS07510	COG0586	Pfam SNARE associated Golgi protein
E3166_RS07520	COG0285	dihydrofolate synthase activity
E3166_RS07525	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E3166_RS07530	COG1286	toxin biosynthetic process
E3166_RS07535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3166_RS07540	COG0163	prenyltransferase activity
E3166_RS07545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS07555	COG4215	(ABC) transporter
E3166_RS07560	COG4160	amino acid transport
E3166_RS07565	COG4598	ABC transporter
E3166_RS07570	COG5464	transposase or invertase
E3166_RS07575	COG1090	epimerase
E3166_RS07580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3166_RS07585	COG0625	glutathione transferase activity
E3166_RS07590	COG0625	glutathione transferase activity
E3166_RS07595	COG0622	Phosphoesterase
E3166_RS07600	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E3166_RS07605	COG1288	antiporter activity
E3166_RS07610	COG0280	phosphate acetyltransferase
E3166_RS07610	COG0857	belongs to the CobB CobQ family
E3166_RS07615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3166_RS07630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3166_RS07635	COG0471	metal ion transport
E3166_RS07635	COG0490	domain, Protein
E3166_RS07645	COG0436	Aminotransferase
E3166_RS07650	COG0583	DNA-binding transcription factor activity
E3166_RS07670	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E3166_RS07675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3166_RS07680	COG1034	ATP synthesis coupled electron transport
E3166_RS07695	COG0839	Belongs to the complex I subunit 6 family
E3166_RS07705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3166_RS07710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3166_RS07735	COG5160	protein modification by small protein removal
E3166_RS07740	COG1234	tRNA 3'-trailer cleavage
E3166_RS07745	COG2153	protein acetylation
E3166_RS07750	COG4575	ribosome binding
E3166_RS07755	COG1169	isochorismate synthase
E3166_RS07770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3166_RS07780	COG0318	PFAM AMP-dependent synthetase and ligase
E3166_RS07825	COG0406	alpha-ribazole phosphatase activity
E3166_RS07845	COG1414	Transcriptional regulator
E3166_RS07850	COG4948	Mandelate Racemase Muconate Lactonizing
E3166_RS07855	COG2271	Major facilitator Superfamily
E3166_RS07870	COG3836	Belongs to the HpcH HpaI aldolase family
E3166_RS07875	COG5464	transposase or invertase
E3166_RS07880	COG0247	lactate metabolic process
E3166_RS07890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3166_RS07895	COG2271	Major facilitator Superfamily
E3166_RS07900	COG0584	glycerophosphoryl diester phosphodiesterase
E3166_RS07910	COG0583	DNA-binding transcription factor activity
E3166_RS07915	COG2814	Major facilitator Superfamily
E3166_RS07920	COG3642	lipopolysaccharide core region biosynthetic process
E3166_RS07925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3166_RS07930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3166_RS07935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3166_RS07940	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS07950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3166_RS07955	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E3166_RS07960	COG3234	Protein of unknown function (DUF1175)
E3166_RS07965	COG2373	Large extracellular alpha-helical protein
E3166_RS07970	COG5445	Predicted secreted protein (DUF2300)
E3166_RS07975	COG5445	Predicted secreted protein (DUF2300)
E3166_RS07980	COG4676	Protein conserved in bacteria
E3166_RS07985	COG2205	protein histidine kinase activity
E3166_RS07985	COG0784	Response regulator, receiver
E3166_RS07990	COG2197	response regulator
E3166_RS07995	COG2198	Histidine kinase
E3166_RS07995	COG0642	Histidine kinase
E3166_RS08000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3166_RS08005	COG1477	protein flavinylation
E3166_RS08010	COG2169	Transcriptional regulator
E3166_RS08010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3166_RS08015	COG3145	DNA-N1-methyladenine dioxygenase activity
E3166_RS08020	COG4615	Cyclic peptide transporter
E3166_RS08035	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS08035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3166_RS08040	COG3062	negative regulation of establishment of protein localization
E3166_RS08050	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS08055	COG0348	domain, Protein
E3166_RS08060	COG3043	anaerobic respiration
E3166_RS08065	COG3005	denitrification pathway
E3166_RS08070	COG4133	protoheme IX ABC transporter activity
E3166_RS08075	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3166_RS08080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3166_RS08085	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3166_RS08095	COG1138	Cytochrome C-type biogenesis protein
E3166_RS08100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3166_RS08105	COG3088	subunit of a heme lyase
E3166_RS08105	COG4235	cytochrome complex assembly
E3166_RS08110	COG2197	response regulator
E3166_RS08115	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS08125	COG3083	sulfuric ester hydrolase activity
E3166_RS08145	COG1061	Type III restriction enzyme res subunit
E3166_RS08150	COG1187	pseudouridine synthase activity
E3166_RS08155	COG2814	Major facilitator Superfamily
E3166_RS08165	COG4172	Belongs to the ABC transporter superfamily
E3166_RS08170	COG4239	(ABC) transporter, permease
E3166_RS08175	COG4174	ABC transporter (Permease)
E3166_RS08180	COG4166	transmembrane transport
E3166_RS08185	COG2200	EAL domain
E3166_RS08190	COG0791	NLP P60 protein
E3166_RS08195	COG0671	phosphoesterase, PA-phosphatase related
E3166_RS08200	COG0523	cobalamin synthesis protein
E3166_RS08205	COG0246	Mannitol dehydrogenase
E3166_RS08220	COG2814	Major facilitator Superfamily
E3166_RS08225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS08225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS08230	COG1105	Belongs to the carbohydrate kinase PfkB family
E3166_RS08235	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E3166_RS08235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS08235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS08240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS08245	COG2313	pseudouridylate synthase activity
E3166_RS08250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3166_RS08255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3166_RS08265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3166_RS08270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS08270	COG1522	sequence-specific DNA binding
E3166_RS08280	COG2855	membrane
E3166_RS08285	COG0583	DNA-binding transcription factor activity
E3166_RS08290	COG0833	amino acid
E3166_RS08295	COG4771	TonB-dependent receptor
E3166_RS08300	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3166_RS08310	COG2311	Membrane
E3166_RS08315	COG1609	Transcriptional regulator
E3166_RS08320	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS08325	COG1129	ABC transporter
E3166_RS08330	COG4211	Belongs to the binding-protein-dependent transport system permease family
E3166_RS08335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3166_RS08335	COG0167	dihydroorotate dehydrogenase activity
E3166_RS08340	COG0493	'glutamate synthase
E3166_RS08350	COG2949	membrane
E3166_RS08360	COG1346	cytolysis
E3166_RS08375	COG2271	Major facilitator Superfamily
E3166_RS08390	COG0625	glutathione transferase activity
E3166_RS08395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3166_RS08400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3166_RS08410	COG1538	Outer membrane efflux protein
E3166_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS08420	COG0586	Pfam SNARE associated Golgi protein
E3166_RS08430	COG1686	Belongs to the peptidase S11 family
E3166_RS08435	COG0277	FAD linked oxidase domain protein
E3166_RS08440	COG1472	Belongs to the glycosyl hydrolase 3 family
E3166_RS08445	COG1732	Glycine betaine
E3166_RS08450	COG1174	glycine betaine transport
E3166_RS08455	COG1125	glycine betaine transport
E3166_RS08460	COG1174	glycine betaine transport
E3166_RS08470	COG0789	Transcriptional regulator
E3166_RS08495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3166_RS08570	COG3772	lysozyme
E3166_RS08615	COG0740	serine-type endopeptidase activity
E3166_RS08690	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS08715	COG3275	phosphorelay sensor kinase activity
E3166_RS08720	COG3279	Response regulator of the LytR AlgR family
E3166_RS08725	COG4807	Protein conserved in bacteria
E3166_RS08730	COG4808	Protein conserved in bacteria
E3166_RS08735	COG4715	Zinc finger, swim domain protein
E3166_RS08740	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E3166_RS08745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E3166_RS08750	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E3166_RS08755	COG0714	Associated with various cellular activities
E3166_RS08765	COG3831	ATPase activity
E3166_RS08785	COG0489	protein tyrosine kinase activity
E3166_RS08795	COG3539	Fimbrial protein
E3166_RS08800	COG3121	Chaperone
E3166_RS08805	COG3188	usher protein
E3166_RS08825	COG5455	response to cobalt ion
E3166_RS08830	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E3166_RS08860	COG0351	phosphomethylpyrimidine kinase
E3166_RS08865	COG3757	hydrolase, family 25
E3166_RS08870	COG2188	Transcriptional regulator
E3166_RS08875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS08880	COG1397	ADP-ribosylglycohydrolase
E3166_RS08885	COG2211	Major facilitator Superfamily
E3166_RS08890	COG1830	Aldolase
E3166_RS08905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS08910	COG3414	Phosphotransferase system galactitol-specific IIB component
E3166_RS08915	COG3775	system Galactitol-specific IIC component
E3166_RS08920	COG1063	alcohol dehydrogenase
E3166_RS08945	COG3422	double-strand break repair
E3166_RS08950	COG0745	RESPONSE REGULATOR receiver
E3166_RS08955	COG2205	protein histidine kinase activity
E3166_RS08970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3166_RS08995	COG4245	von Willebrand factor, type A
E3166_RS09000	COG0631	protein serine/threonine phosphatase activity
E3166_RS09005	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E3166_RS09010	COG0443	Heat shock 70 kDa protein
E3166_RS09015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E3166_RS09025	COG0572	uridine kinase
E3166_RS09035	COG2982	Protein involved in outer membrane biogenesis
E3166_RS09050	COG1253	flavin adenine dinucleotide binding
E3166_RS09060	COG1596	polysaccharide export
E3166_RS09065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3166_RS09070	COG3206	protein involved in exopolysaccharide biosynthesis
E3166_RS09070	COG0489	protein tyrosine kinase activity
E3166_RS09075	COG0463	Glycosyl transferase, family 2
E3166_RS09080	COG1045	serine acetyltransferase
E3166_RS09085	COG0438	transferase activity, transferring glycosyl groups
E3166_RS09095	COG1216	Glycosyl transferase, family 2
E3166_RS09100	COG0110	maltose O-acetyltransferase activity
E3166_RS09105	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E3166_RS09110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3166_RS09115	COG1051	belongs to the nudix hydrolase family
E3166_RS09120	COG0297	glycogen (starch) synthase activity
E3166_RS09125	COG0662	Cupin 2, conserved barrel domain protein
E3166_RS09125	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3166_RS09130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3166_RS09135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3166_RS09140	COG2244	polysaccharide biosynthetic process
E3166_RS09145	COG2327	Polysaccharide pyruvyl transferase
E3166_RS09150	COG0438	transferase activity, transferring glycosyl groups
E3166_RS09160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3166_RS09165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3166_RS09190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3166_RS09200	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E3166_RS09205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3166_RS09210	COG1051	belongs to the nudix hydrolase family
E3166_RS09215	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3166_RS09215	COG0662	Cupin 2, conserved barrel domain protein
E3166_RS09220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3166_RS09230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E3166_RS09235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3166_RS09260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3166_RS09265	COG0131	Imidazoleglycerol-phosphate dehydratase
E3166_RS09265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3166_RS09275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3166_RS09290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3166_RS09295	COG0583	DNA-binding transcription factor activity
E3166_RS09305	COG0531	amino acid
E3166_RS09310	COG2391	methyltransferase activity
E3166_RS09315	COG0425	Belongs to the sulfur carrier protein TusA family
E3166_RS09320	COG2925	Exonuclease
E3166_RS09325	COG0582	viral genome integration into host DNA
E3166_RS09530	COG3772	lysozyme
E3166_RS09635	COG1185	polyribonucleotide nucleotidyltransferase activity
E3166_RS09665	COG3436	PFAM IS66 Orf2 family protein
E3166_RS09670	COG4372	Transposase
E3166_RS09685	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS09695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3166_RS09705	COG1686	Belongs to the peptidase S11 family
E3166_RS09715	COG1289	transmembrane transporter activity
E3166_RS09725	COG4917	ethanolamine utilization protein
E3166_RS09760	COG2003	Belongs to the UPF0758 family
E3166_RS09805	COG4771	TonB-dependent receptor
E3166_RS09810	COG4372	Transposase
E3166_RS09815	COG3436	PFAM IS66 Orf2 family protein
E3166_RS09825	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E3166_RS09840	COG1376	ErfK ybiS ycfS ynhG family protein
E3166_RS09850	COG0583	DNA-binding transcription factor activity
E3166_RS09855	COG0583	DNA-binding transcription factor activity
E3166_RS09865	COG0534	Mate efflux family protein
E3166_RS09875	COG0217	transcriptional regulatory protein
E3166_RS09880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3166_RS09885	COG0477	Major facilitator Superfamily
E3166_RS09935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS09980	COG1846	Transcriptional regulator
E3166_RS10025	COG1403	HNH endonuclease
E3166_RS10030	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS10085	COG3772	lysozyme
E3166_RS10115	COG4220	transposase activity
E3166_RS10200	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS10220	COG3038	cytochrome b561
E3166_RS10225	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3166_RS10240	COG2351	hydroxyisourate hydrolase activity
E3166_RS10245	COG0745	RESPONSE REGULATOR receiver
E3166_RS10250	COG2205	protein histidine kinase activity
E3166_RS10270	COG1418	mRNA catabolic process
E3166_RS10275	COG0270	DNA (cytosine-5-)-methyltransferase activity
E3166_RS10280	COG3727	T/G mismatch-specific endonuclease activity
E3166_RS10285	COG0697	spore germination
E3166_RS10290	COG2354	Protein conserved in bacteria
E3166_RS10295	COG5475	Uncharacterized small protein (DUF2158)
E3166_RS10300	COG3706	GGDEF domain
E3166_RS10320	COG2197	response regulator
E3166_RS10325	COG1684	flagellar biosynthetic protein fliR
E3166_RS10330	COG1987	bacterial-type flagellum assembly
E3166_RS10335	COG1338	Plays a role in the flagellum-specific transport system
E3166_RS10340	COG3190	flagellar
E3166_RS10345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3166_RS10350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3166_RS10355	COG1580	Controls the rotational direction of flagella during chemotaxis
E3166_RS10360	COG3144	bacterial-type flagellum assembly
E3166_RS10365	COG2882	bacterial-type flagellum organization
E3166_RS10370	COG1157	protein secretion by the type III secretion system
E3166_RS10375	COG1317	bacterial-type flagellum organization
E3166_RS10380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3166_RS10385	COG1766	The M ring may be actively involved in energy transduction
E3166_RS10400	COG0454	-acetyltransferase
E3166_RS10410	COG0454	-acetyltransferase
E3166_RS10415	COG2135	peptidase activity
E3166_RS10420	COG0425	Belongs to the sulfur carrier protein TusA family
E3166_RS10425	COG2391	methyltransferase activity
E3166_RS10435	COG0366	Alpha amylase catalytic
E3166_RS10445	COG1516	flagellar protein fliS
E3166_RS10450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E3166_RS10460	COG1191	sigma factor activity
E3166_RS10490	COG2197	response regulator
E3166_RS10505	COG2197	response regulator
E3166_RS10580	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3166_RS10680	COG4974	Belongs to the 'phage' integrase family
E3166_RS10685	COG3012	SEC-C Motif Domain Protein
E3166_RS10685	COG3318	Belongs to the UPF0149 family
E3166_RS10690	COG0814	amino acid
E3166_RS10700	COG1528	Iron-storage protein
E3166_RS10720	COG1528	Iron-storage protein
E3166_RS10725	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS10730	COG1129	ABC transporter
E3166_RS10735	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS10740	COG1877	trehalose-phosphatase activity
E3166_RS10750	COG0589	response to stress
E3166_RS10765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3166_RS10770	COG1360	Flagellar Motor Protein
E3166_RS10775	COG2198	Histidine kinase
E3166_RS10775	COG0643	Histidine kinase
E3166_RS10780	COG0835	chemotaxis
E3166_RS10785	COG0840	transmembrane signaling receptor activity
E3166_RS10790	COG0840	transmembrane signaling receptor activity
E3166_RS10795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3166_RS10800	COG2201	protein-glutamate methylesterase activity
E3166_RS10805	COG0745	RESPONSE REGULATOR receiver
E3166_RS10815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3166_RS10820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3166_RS10830	COG3755	Protein conserved in bacteria
E3166_RS10840	COG3102	Protein conserved in bacteria
E3166_RS10850	COG3005	denitrification pathway
E3166_RS10855	COG0243	molybdopterin cofactor binding
E3166_RS10870	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E3166_RS10875	COG1801	Protein of unknown function DUF72
E3166_RS10880	COG1335	isochorismatase
E3166_RS10890	COG0494	nUDIX hydrolase
E3166_RS10895	COG0217	transcriptional regulatory protein
E3166_RS10925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3166_RS10935	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E3166_RS10940	COG0739	heme binding
E3166_RS10945	COG1560	Kdo2-lipid A biosynthetic process
E3166_RS10950	COG0469	pyruvate kinase activity
E3166_RS10955	COG1737	Transcriptional regulator
E3166_RS10960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3166_RS10965	COG0129	dihydroxy-acid dehydratase activity
E3166_RS10970	COG0800	Aldolase
E3166_RS10975	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E3166_RS10980	COG3141	response to X-ray
E3166_RS10990	COG2979	Protein of unknown function (DUF533)
E3166_RS10995	COG1770	oligopeptidase
E3166_RS11000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS11005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3166_RS11015	COG2372	response to copper ion
E3166_RS11020	COG1276	copper resistance
E3166_RS11030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3166_RS11050	COG3008	intermembrane lipid transfer
E3166_RS11055	COG2995	paraquat-inducible protein a
E3166_RS11060	COG1956	GAF domain-containing protein
E3166_RS11070	COG0793	Belongs to the peptidase S41A family
E3166_RS11080	COG2814	Major facilitator Superfamily
E3166_RS11085	COG1414	Transcriptional regulator
E3166_RS11115	COG2226	methyltransferase
E3166_RS11130	COG3716	PTS system mannose fructose sorbose family IID component
E3166_RS11135	COG3715	PTS system
E3166_RS11140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS11140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS11145	COG1253	flavin adenine dinucleotide binding
E3166_RS11150	COG2200	EAL domain
E3166_RS11155	COG1760	l-serine dehydratase
E3166_RS11165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3166_RS11180	COG0251	oxidation-reduction process
E3166_RS11185	COG1199	ATP-dependent helicase activity
E3166_RS11190	COG1214	PFAM Peptidase M22, glycoprotease
E3166_RS11195	COG3065	identical protein binding
E3166_RS11200	COG0318	PFAM AMP-dependent synthetase and ligase
E3166_RS11205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3166_RS11210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3166_RS11215	COG4638	Rieske (2fe-2S)
E3166_RS11220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3166_RS11225	COG0473	3-isopropylmalate dehydrogenase activity
E3166_RS11230	COG0583	DNA-binding transcription factor activity
E3166_RS11235	COG1280	lysine exporter protein (LysE YggA)
E3166_RS11240	COG3615	Tellurite resistance protein tehB
E3166_RS11250	COG2261	transglycosylase associated protein
E3166_RS11265	COG2203	Gaf domain
E3166_RS11265	COG2199	diguanylate cyclase activity
E3166_RS11270	COG3042	response to heat
E3166_RS11275	COG3189	MarR family transcriptional regulator
E3166_RS11280	COG2807	transmembrane transport
E3166_RS11285	COG2207	Transcriptional regulator
E3166_RS11300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3166_RS11305	COG2199	diguanylate cyclase activity
E3166_RS11310	COG2199	diguanylate cyclase activity
E3166_RS11320	COG2766	serine protein kinase
E3166_RS11325	COG3713	MltA-interacting MipA family protein
E3166_RS11330	COG0656	L-ascorbic acid biosynthetic process
E3166_RS11335	COG0676	glucose-6-phosphate 1-epimerase activity
E3166_RS11340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3166_RS11350	COG3139	Protein of unknown function (DUF1315)
E3166_RS11355	COG1063	alcohol dehydrogenase
E3166_RS11360	COG2271	Major facilitator Superfamily
E3166_RS11365	COG1063	alcohol dehydrogenase
E3166_RS11370	COG0191	fructose-bisphosphate aldolase activity
E3166_RS11375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS11380	COG0667	Aldo Keto reductase
E3166_RS11385	COG1349	DNA-binding transcription factor activity
E3166_RS11400	COG1335	isochorismatase
E3166_RS11405	COG0252	asparaginase activity
E3166_RS11415	COG0616	signal peptide processing
E3166_RS11420	COG0778	Nitroreductase
E3166_RS11425	COG0709	Synthesizes selenophosphate from selenide and ATP
E3166_RS11430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3166_RS11440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3166_RS11450	COG0494	nUDIX hydrolase
E3166_RS11455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3166_RS11460	COG2897	thiosulfate sulfurtransferase activity
E3166_RS11465	COG4136	ATPase activity
E3166_RS11470	COG4135	transport system, permease component
E3166_RS11475	COG4134	Bacterial extracellular solute-binding protein
E3166_RS11480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3166_RS11485	COG0398	Pfam SNARE associated Golgi protein
E3166_RS11495	COG0398	Pfam SNARE associated Golgi protein
E3166_RS11500	COG0708	Exodeoxyribonuclease III
E3166_RS11530	COG3678	ATP-independent chaperone mediated protein folding
E3166_RS11540	COG0322	excinuclease ABC activity
E3166_RS11550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3166_RS11555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3166_RS11560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3166_RS11565	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3166_RS11570	COG1917	Cupin 2, conserved barrel domain protein
E3166_RS11570	COG2169	Transcriptional regulator
E3166_RS11575	COG1486	melibiose metabolic process
E3166_RS11585	COG0753	catalase activity
E3166_RS11605	COG1988	membrane-bound metal-dependent
E3166_RS11610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3166_RS11620	COG3001	Fructosamine kinase
E3166_RS11630	COG1105	Belongs to the carbohydrate kinase PfkB family
E3166_RS11635	COG3137	Salt-induced outer membrane protein
E3166_RS11680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3166_RS11680	COG0072	phenylalanine-tRNA ligase activity
E3166_RS11695	COG0386	Belongs to the glutathione peroxidase family
E3166_RS11705	COG0791	NLP P60 protein
E3166_RS11710	COG2200	EAL domain
E3166_RS11720	COG4256	Hemin uptake protein
E3166_RS11725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3166_RS11735	COG0574	Belongs to the PEP-utilizing enzyme family
E3166_RS11735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3166_RS11740	COG0318	PFAM AMP-dependent synthetase and ligase
E3166_RS11745	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3166_RS11750	COG0644	oxidoreductase
E3166_RS11755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3166_RS11760	COG2086	electron transfer activity
E3166_RS11765	COG2207	Transcriptional regulator
E3166_RS11765	COG1917	Cupin 2, conserved barrel domain protein
E3166_RS11770	COG1960	acyl-CoA dehydrogenase activity
E3166_RS11775	COG4670	ketone body catabolic process
E3166_RS11790	COG2271	Major facilitator Superfamily
E3166_RS11795	COG0738	Major facilitator superfamily
E3166_RS11810	COG0628	permease
E3166_RS11815	COG0277	FAD linked oxidase domain protein
E3166_RS11815	COG0247	lactate metabolic process
E3166_RS11820	COG2050	protein possibly involved in aromatic compounds catabolism
E3166_RS11830	COG0316	Belongs to the HesB IscA family
E3166_RS11835	COG0719	Fe-S assembly protein
E3166_RS11840	COG0396	ATPase activity
E3166_RS11845	COG0719	Fe-S assembly protein
E3166_RS11860	COG1376	ErfK ybiS ycfS ynhG family protein
E3166_RS11865	COG4238	major outer membrane lipoprotein
E3166_RS11870	COG0469	pyruvate kinase activity
E3166_RS11880	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS11885	COG2414	aldehyde ferredoxin oxidoreductase
E3166_RS11895	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS11900	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E3166_RS11910	COG4529	Protein conserved in bacteria
E3166_RS11930	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS11940	COG0307	riboflavin synthase, alpha
E3166_RS11945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3166_RS11950	COG2814	Major facilitator Superfamily
E3166_RS11955	COG0583	DNA-binding transcription factor activity
E3166_RS11970	COG2814	Major facilitator Superfamily
E3166_RS11975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3166_RS11980	COG0791	NLP P60 protein
E3166_RS11985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3166_RS11990	COG1201	RNA secondary structure unwinding
E3166_RS12000	COG0346	lactoylglutathione lyase activity
E3166_RS12005	COG1902	pentaerythritol trinitrate reductase activity
E3166_RS12010	COG1309	transcriptional regulator
E3166_RS12015	COG3313	Fe-S protein
E3166_RS12025	COG2032	superoxide dismutase activity
E3166_RS12035	COG1566	PFAM secretion protein HlyD family protein
E3166_RS12050	COG3133	Outer membrane lipoprotein
E3166_RS12060	COG3895	Periplasmic Protein
E3166_RS12075	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3166_RS12080	COG0625	glutathione transferase activity
E3166_RS12085	COG3104	oligopeptide transport
E3166_RS12090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3166_RS12100	COG4659	FMN binding
E3166_RS12140	COG0673	inositol 2-dehydrogenase activity
E3166_RS12150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3166_RS12155	COG1263	PTS System
E3166_RS12155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS12160	COG1609	Transcriptional regulator
E3166_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS12170	COG1309	transcriptional regulator
E3166_RS12190	COG5339	Protein conserved in bacteria
E3166_RS12195	COG1482	cell wall glycoprotein biosynthetic process
E3166_RS12200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS12200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS12205	COG0114	fumarate hydratase activity
E3166_RS12215	COG2205	protein histidine kinase activity
E3166_RS12220	COG0745	RESPONSE REGULATOR receiver
E3166_RS12225	COG3136	membrane protein required for alginate biosynthesis
E3166_RS12235	COG0531	amino acid
E3166_RS12245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3166_RS12250	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3166_RS12255	COG0628	permease
E3166_RS12270	COG3591	Belongs to the peptidase S1B family
E3166_RS12285	COG2814	Major facilitator Superfamily
E3166_RS12290	COG0583	DNA-binding transcription factor activity
E3166_RS12295	COG1940	carbohydrate kinase activity
E3166_RS12300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3166_RS12310	COG3381	protein complex oligomerization
E3166_RS12315	COG3302	dmso reductase anchor subunit
E3166_RS12320	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS12325	COG0243	molybdopterin cofactor binding
E3166_RS12330	COG0243	molybdopterin cofactor binding
E3166_RS12345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3166_RS12370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS12425	COG1846	Transcriptional regulator
E3166_RS12430	COG1484	DNA-dependent DNA replication
E3166_RS12465	COG1403	HNH endonuclease
E3166_RS12470	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS12520	COG3772	lysozyme
E3166_RS12660	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS12680	COG4372	Transposase
E3166_RS12685	COG3436	PFAM IS66 Orf2 family protein
E3166_RS12710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS12765	COG1846	Transcriptional regulator
E3166_RS12800	COG3111	PFAM Bacterial OB fold (BOF) protein
E3166_RS12810	COG1403	HNH endonuclease
E3166_RS12815	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS12830	COG2207	Transcriptional regulator
E3166_RS12870	COG3772	lysozyme
E3166_RS12995	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS13040	COG4372	Transposase
E3166_RS13045	COG3436	PFAM IS66 Orf2 family protein
E3166_RS13095	COG3685	Protein conserved in bacteria
E3166_RS13100	COG3685	Protein conserved in bacteria
E3166_RS13105	COG3729	General stress protein
E3166_RS13120	COG0135	phosphoribosylanthranilate isomerase activity
E3166_RS13120	COG0134	indole-3-glycerol-phosphate synthase activity
E3166_RS13125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3166_RS13125	COG0512	Glutamine amidotransferase of anthranilate synthase
E3166_RS13130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3166_RS13140	COG0613	PHP domain protein
E3166_RS13145	COG0009	L-threonylcarbamoyladenylate synthase
E3166_RS13165	COG1187	pseudouridine synthase activity
E3166_RS13170	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E3166_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS13180	COG0616	signal peptide processing
E3166_RS13190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3166_RS13195	COG0583	DNA-binding transcription factor activity
E3166_RS13215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3166_RS13225	COG0671	phosphoesterase, PA-phosphatase related
E3166_RS13230	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E3166_RS13235	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E3166_RS13245	COG0023	Translation Initiation Factor
E3166_RS13255	COG1349	DNA-binding transcription factor activity
E3166_RS13265	COG5001	Diguanylate cyclase
E3166_RS13275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3166_RS13275	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3166_RS13280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3166_RS13310	COG2814	Major facilitator Superfamily
E3166_RS13315	COG4172	Belongs to the ABC transporter superfamily
E3166_RS13320	COG4172	Belongs to the ABC transporter superfamily
E3166_RS13325	COG4171	peptide transport system, permease
E3166_RS13330	COG4168	peptide transport system, permease
E3166_RS13335	COG4166	transmembrane transport
E3166_RS13345	COG0531	amino acid
E3166_RS13355	COG0174	glutamine synthetase
E3166_RS13360	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3166_RS13365	COG1917	Cupin 2, conserved barrel domain protein
E3166_RS13365	COG1396	sequence-specific DNA binding
E3166_RS13370	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS13375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3166_RS13380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3166_RS13385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E3166_RS13390	COG1842	Phage shock protein A
E3166_RS13400	COG1983	PspC domain protein
E3166_RS13410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3166_RS13425	COG1175	transmembrane transport
E3166_RS13430	COG0395	ABC-type sugar transport system, permease component
E3166_RS13435	COG1063	alcohol dehydrogenase
E3166_RS13440	COG1082	Xylose isomerase domain protein TIM barrel
E3166_RS13445	COG0673	inositol 2-dehydrogenase activity
E3166_RS13450	COG1554	hydrolase, family 65, central catalytic
E3166_RS13455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3166_RS13460	COG3842	ATPase activity
E3166_RS13470	COG1609	Transcriptional regulator
E3166_RS13475	COG3106	COG3106 Predicted ATPase
E3166_RS13485	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E3166_RS13490	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E3166_RS13495	COG4948	Mandelate Racemase Muconate Lactonizing
E3166_RS13500	COG2866	Carboxypeptidase
E3166_RS13505	COG0702	epimerase
E3166_RS13515	COG1073	alpha beta
E3166_RS13520	COG0583	DNA-binding transcription factor activity
E3166_RS13525	COG4166	transmembrane transport
E3166_RS13530	COG0668	transmembrane transport
E3166_RS13535	COG3182	Iron-regulated membrane protein
E3166_RS13540	COG0589	response to stress
E3166_RS13545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3166_RS13550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3166_RS13555	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E3166_RS13560	COG1473	amidohydrolase
E3166_RS13565	COG1473	amidohydrolase
E3166_RS13570	COG0583	DNA-binding transcription factor activity
E3166_RS13575	COG2840	Smr protein MutS2
E3166_RS13580	COG3706	GGDEF domain
E3166_RS13595	COG0513	Belongs to the DEAD box helicase family
E3166_RS13605	COG0589	response to stress
E3166_RS13615	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3166_RS13615	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3166_RS13615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3166_RS13615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3166_RS13620	COG3042	response to heat
E3166_RS13625	COG3187	Heat shock protein
E3166_RS13630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3166_RS13635	COG2911	Protein conserved in bacteria
E3166_RS13645	COG3784	Protein of unknown function (DUF1318)
E3166_RS13660	COG0667	Aldo Keto reductase
E3166_RS13670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3166_RS13675	COG4589	Belongs to the CDS family
E3166_RS13685	COG2453	phosphatase
E3166_RS13685	COG0671	phosphoesterase, PA-phosphatase related
E3166_RS13690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3166_RS13695	COG1643	Atp-dependent helicase
E3166_RS13720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3166_RS13725	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS13730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3166_RS13735	COG3038	cytochrome b561
E3166_RS13750	COG0840	transmembrane signaling receptor activity
E3166_RS13755	COG0583	DNA-binding transcription factor activity
E3166_RS13760	COG5383	Protein conserved in bacteria
E3166_RS13770	COG2841	Protein conserved in bacteria
E3166_RS13780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3166_RS13785	COG1275	C4-dicarboxylate transporter malic acid transport protein
E3166_RS13790	COG0500	methyltransferase
E3166_RS13800	COG3135	benzoate transporter
E3166_RS13805	COG1396	sequence-specific DNA binding
E3166_RS13810	COG0826	peptidase U32
E3166_RS13820	COG1724	mRNA binding
E3166_RS13825	COG1598	PFAM Uncharacterised protein family UPF0150
E3166_RS13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3166_RS13835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3166_RS13840	COG3842	ATPase activity
E3166_RS13845	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3166_RS13850	COG1177	transmembrane transport
E3166_RS13875	COG3238	Protein conserved in bacteria
E3166_RS13880	COG1247	-acetyltransferase
E3166_RS13885	COG2130	NADP-dependent
E3166_RS13890	COG1802	Transcriptional regulator
E3166_RS13895	COG4772	TonB-dependent receptor
E3166_RS13900	COG3391	amine dehydrogenase activity
E3166_RS13905	COG1113	amino acid transport
E3166_RS13910	COG0625	glutathione transferase activity
E3166_RS13920	COG3501	Rhs element vgr protein
E3166_RS13950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3166_RS13960	COG0384	phenazine biosynthesis protein PhzF
E3166_RS13965	COG2181	nitrate reductase activity
E3166_RS13970	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3166_RS13975	COG1140	nitrate reductase beta subunit
E3166_RS13980	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3166_RS13985	COG2223	nitrite transmembrane transporter activity
E3166_RS13990	COG4886	Leucine-rich repeat (LRR) protein
E3166_RS13995	COG4886	Leucine-rich repeat (LRR) protein
E3166_RS14010	COG0697	spore germination
E3166_RS14020	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS14025	COG2864	formate dehydrogenase
E3166_RS14030	COG3093	addiction module antidote protein HigA
E3166_RS14035	COG1064	alcohol dehydrogenase
E3166_RS14055	COG1764	response to oxidative stress
E3166_RS14060	COG4608	Belongs to the ABC transporter superfamily
E3166_RS14065	COG0444	Belongs to the ABC transporter superfamily
E3166_RS14070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3166_RS14080	COG0747	negative chemotaxis
E3166_RS14085	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E3166_RS14090	COG2200	EAL domain
E3166_RS14090	COG2199	diguanylate cyclase activity
E3166_RS14090	COG2202	Pas domain
E3166_RS14095	COG3706	GGDEF domain
E3166_RS14105	COG0531	amino acid
E3166_RS14110	COG0076	glutamate decarboxylase activity
E3166_RS14115	COG0612	Peptidase, M16
E3166_RS14120	COG4771	TonB-dependent receptor
E3166_RS14125	COG4178	(ABC) transporter
E3166_RS14135	COG0641	radical SAM
E3166_RS14140	COG3119	arylsulfatase activity
E3166_RS14145	COG2207	Transcriptional regulator
E3166_RS14155	COG0243	molybdopterin cofactor binding
E3166_RS14160	COG3539	Fimbrial protein
E3166_RS14165	COG3539	Fimbrial protein
E3166_RS14170	COG3539	Fimbrial protein
E3166_RS14175	COG3188	usher protein
E3166_RS14185	COG3539	Fimbrial protein
E3166_RS14205	COG1070	Carbohydrate kinase
E3166_RS14215	COG1129	ABC transporter
E3166_RS14220	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS14225	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS14235	COG1830	Aldolase
E3166_RS14250	COG3781	membrane
E3166_RS14260	COG2199	diguanylate cyclase activity
E3166_RS14270	COG2066	Belongs to the glutaminase family
E3166_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS14280	COG0583	DNA-binding transcription factor activity
E3166_RS14295	COG2814	Major facilitator Superfamily
E3166_RS14300	COG2095	MarC family integral membrane protein
E3166_RS14305	COG1846	Transcriptional regulator
E3166_RS14310	COG4977	sequence-specific DNA binding
E3166_RS14320	COG0697	spore germination
E3166_RS14325	COG2814	Major facilitator Superfamily
E3166_RS14345	COG3706	GGDEF domain
E3166_RS14350	COG3111	PFAM Bacterial OB fold (BOF) protein
E3166_RS14355	COG1546	Belongs to the CinA family
E3166_RS14360	COG0339	signal peptide processing
E3166_RS14365	COG4221	oxidoreductase activity
E3166_RS14370	COG1802	Transcriptional regulator
E3166_RS14380	COG0246	Mannitol dehydrogenase
E3166_RS14385	COG0477	Major facilitator Superfamily
E3166_RS14415	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS14500	COG1030	water channel activity
E3166_RS14520	COG4220	transposase activity
E3166_RS14550	COG3772	lysozyme
E3166_RS14595	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS14600	COG1403	HNH endonuclease
E3166_RS14630	COG1846	Transcriptional regulator
E3166_RS14655	COG1396	sequence-specific DNA binding
E3166_RS14695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS14705	COG0582	viral genome integration into host DNA
E3166_RS14710	COG3047	cAMP biosynthetic process
E3166_RS14730	COG1607	acyl-coa hydrolase
E3166_RS14735	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E3166_RS14740	COG2350	Protein conserved in bacteria
E3166_RS14745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3166_RS14765	COG4608	Belongs to the ABC transporter superfamily
E3166_RS14770	COG0444	Belongs to the ABC transporter superfamily
E3166_RS14775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3166_RS14780	COG0601	transmembrane transport
E3166_RS14785	COG4166	transmembrane transport
E3166_RS14790	COG2095	MarC family integral membrane protein
E3166_RS14795	COG1454	alcohol dehydrogenase
E3166_RS14795	COG1012	belongs to the aldehyde dehydrogenase family
E3166_RS14800	COG1435	thymidine kinase activity
E3166_RS14810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3166_RS14815	COG0745	RESPONSE REGULATOR receiver
E3166_RS14820	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3166_RS14830	COG0788	formyltetrahydrofolate deformylase activity
E3166_RS14860	COG2181	nitrate reductase activity
E3166_RS14865	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3166_RS14870	COG1140	nitrate reductase beta subunit
E3166_RS14875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3166_RS14880	COG2223	nitrite transmembrane transporter activity
E3166_RS14885	COG3850	Histidine kinase
E3166_RS14890	COG2197	response regulator
E3166_RS14895	COG4932	domain protein
E3166_RS14900	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E3166_RS14905	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E3166_RS14910	COG4572	Cation transport regulator
E3166_RS14915	COG0387	Pfam Sodium calcium exchanger
E3166_RS14935	COG2912	Transglutaminase-like superfamily
E3166_RS14940	COG3094	Invasion gene expression up-regulator, SirB
E3166_RS14970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3166_RS14975	COG0659	secondary active sulfate transmembrane transporter activity
E3166_RS14990	COG0012	GTP binding
E3166_RS14995	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS15000	COG3284	Transcriptional regulator
E3166_RS15005	COG2376	Dihydroxyacetone kinase
E3166_RS15010	COG1461	Dihydroxyacetone kinase
E3166_RS15015	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E3166_RS15015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS15015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3166_RS15040	COG1120	ATPase activity
E3166_RS15045	COG0500	methyltransferase
E3166_RS15050	COG0157	Belongs to the NadC ModD family
E3166_RS15075	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3166_RS15085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3166_RS15095	COG2719	SpoVR family
E3166_RS15110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3166_RS15115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3166_RS15120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3166_RS15135	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3166_RS15165	COG2894	cell division
E3166_RS15185	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS15185	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS15225	COG2200	EAL domain
E3166_RS15250	COG2200	EAL domain
E3166_RS15255	COG0789	Transcriptional regulator
E3166_RS15260	COG5562	phage envelope protein
E3166_RS15275	COG0538	isocitrate dehydrogenase activity
E3166_RS15280	COG0456	acetyltransferase
E3166_RS15290	COG4571	Outer membrane protease
E3166_RS15300	COG4372	Transposase
E3166_RS15305	COG3436	PFAM IS66 Orf2 family protein
E3166_RS15320	COG0500	methyltransferase
E3166_RS15325	COG3729	General stress protein
E3166_RS15330	COG3685	Protein conserved in bacteria
E3166_RS15335	COG3685	Protein conserved in bacteria
E3166_RS15340	COG3546	catalase activity
E3166_RS15345	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3166_RS15350	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS15385	COG1196	nuclear chromosome segregation
E3166_RS15435	COG1030	water channel activity
E3166_RS15455	COG4220	transposase activity
E3166_RS15470	COG5562	phage envelope protein
E3166_RS15505	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS15525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3166_RS15535	COG2076	Multidrug Resistance protein
E3166_RS15560	COG0582	viral genome integration into host DNA
E3166_RS15565	COG0538	isocitrate dehydrogenase activity
E3166_RS15570	COG1187	pseudouridine synthase activity
E3166_RS15580	COG0482	sulfurtransferase activity
E3166_RS15590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3166_RS15595	COG0745	RESPONSE REGULATOR receiver
E3166_RS15600	COG2205	protein histidine kinase activity
E3166_RS15610	COG4220	transposase activity
E3166_RS15700	COG2850	peptidyl-arginine hydroxylation
E3166_RS15710	COG3842	ATPase activity
E3166_RS15905	COG3772	lysozyme
E3166_RS15945	COG0484	heat shock protein binding
E3166_RS15950	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS15955	COG1403	HNH endonuclease
E3166_RS16010	COG1846	Transcriptional regulator
E3166_RS16030	COG4197	protein conserved in bacteria, prophage-related
E3166_RS16060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS16070	COG0582	viral genome integration into host DNA
E3166_RS16075	COG1177	transmembrane transport
E3166_RS16080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3166_RS16085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3166_RS16095	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3166_RS16100	COG1136	(ABC) transporter
E3166_RS16105	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3166_RS16110	COG4763	Acyl-transferase
E3166_RS16115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3166_RS16120	COG1388	LysM domain
E3166_RS16120	COG1376	ErfK ybiS ycfS ynhG family protein
E3166_RS16130	COG1309	transcriptional regulator
E3166_RS16135	COG3134	Outer membrane lipoprotein
E3166_RS16140	COG1252	NADH dehydrogenase
E3166_RS16155	COG0510	thiamine kinase activity
E3166_RS16160	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E3166_RS16165	COG5633	Lipoprotein
E3166_RS16170	COG0537	adenosine 5'-monophosphoramidase activity
E3166_RS16180	COG4773	Receptor
E3166_RS16185	COG1263	PTS System
E3166_RS16185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS16190	COG0084	hydrolase, TatD family'
E3166_RS16195	COG0470	DNA polymerase III
E3166_RS16205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3166_RS16210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3166_RS16215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3166_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS16230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3166_RS16250	COG1399	metal-binding, possibly nucleic acid-binding protein
E3166_RS16255	COG0424	maF-like protein
E3166_RS16260	COG0564	pseudouridine synthase activity
E3166_RS16265	COG1530	ribonuclease E activity
E3166_RS16270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3166_RS16275	COG1256	bacterial-type flagellum assembly
E3166_RS16280	COG3951	Flagellar rod assembly protein muramidase FlgJ
E3166_RS16280	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3166_RS16295	COG4786	Flagellar basal body rod
E3166_RS16300	COG4787	bacterial-type flagellum-dependent cell motility
E3166_RS16305	COG1749	Flagellar hook protein flgE
E3166_RS16310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3166_RS16315	COG1558	bacterial-type flagellum-dependent cell motility
E3166_RS16320	COG1815	bacterial-type flagellum-dependent cell motility
E3166_RS16325	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E3166_RS16330	COG2747	anti-sigma28 factor FlgM
E3166_RS16335	COG3418	PFAM FlgN family protein
E3166_RS16340	COG0728	peptidoglycan biosynthetic process
E3166_RS16345	COG0673	inositol 2-dehydrogenase activity
E3166_RS16355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3166_RS16365	COG2999	glutathione oxidoreductase activity
E3166_RS16400	COG3038	cytochrome b561
E3166_RS16405	COG2353	YceI-like domain
E3166_RS16415	COG1560	Kdo2-lipid A biosynthetic process
E3166_RS16430	COG5645	(Lipo)protein
E3166_RS16435	COG2943	transferase activity, transferring hexosyl groups
E3166_RS16450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3166_RS16455	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3166_RS16480	COG2197	response regulator
E3166_RS16495	COG1462	curli production assembly transport component CsgG
E3166_RS16505	COG3381	protein complex oligomerization
E3166_RS16555	COG2003	Belongs to the UPF0758 family
E3166_RS16630	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E3166_RS16640	COG2831	hemolysin activation secretion protein
E3166_RS16725	COG4771	TonB-dependent receptor
E3166_RS16785	COG1358	cellular component organization or biogenesis
E3166_RS16820	COG4372	Transposase
E3166_RS16825	COG3436	PFAM IS66 Orf2 family protein
E3166_RS16860	COG4372	Transposase
E3166_RS16865	COG3436	PFAM IS66 Orf2 family protein
E3166_RS16905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3166_RS16910	COG2194	sulfuric ester hydrolase activity
E3166_RS16920	COG0829	nickel cation binding
E3166_RS16965	COG0254	rRNA binding
E3166_RS17000	COG4983	Phage plasmid primase, P4 family domain protein
E3166_RS17025	COG0582	viral genome integration into host DNA
E3166_RS17075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3166_RS17080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3166_RS17090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3166_RS17100	COG0736	holo-[acyl-carrier-protein] synthase activity
E3166_RS17105	COG2831	hemolysin activation secretion protein
E3166_RS17110	COG3210	domain, Protein
E3166_RS17120	COG3539	Fimbrial protein
E3166_RS17130	COG3188	usher protein
E3166_RS17140	COG3121	Chaperone
E3166_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS17150	COG3710	Transcriptional regulator
E3166_RS17160	COG2200	EAL domain
E3166_RS17165	COG3706	GGDEF domain
E3166_RS17170	COG0457	Tetratricopeptide repeat
E3166_RS17175	COG1649	PFAM Uncharacterised BCR, COG1649
E3166_RS17175	COG0726	polysaccharide deacetylase
E3166_RS17180	COG1215	transferase activity, transferring glycosyl groups
E3166_RS17185	COG3658	cytochrome
E3166_RS17190	COG1702	phosphate starvation-inducible protein PhoH
E3166_RS17195	COG2837	iron assimilation
E3166_RS17200	COG2822	iron ion transport
E3166_RS17215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3166_RS17225	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3166_RS17225	COG0506	proline dehydrogenase activity
E3166_RS17225	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3166_RS17230	COG1309	transcriptional regulator
E3166_RS17265	COG2233	PERMEase
E3166_RS17270	COG3729	General stress protein
E3166_RS17310	COG0243	molybdopterin cofactor binding
E3166_RS17315	COG3005	denitrification pathway
E3166_RS17320	COG0745	RESPONSE REGULATOR receiver
E3166_RS17325	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS17330	COG0784	Response regulator, receiver
E3166_RS17330	COG2198	Histidine kinase
E3166_RS17330	COG2205	protein histidine kinase activity
E3166_RS17335	COG0348	domain, Protein
E3166_RS17355	COG1278	Cold shock
E3166_RS17360	COG1278	Cold shock
E3166_RS17380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3166_RS17385	COG1596	polysaccharide export
E3166_RS17390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3166_RS17395	COG0489	protein tyrosine kinase activity
E3166_RS17395	COG3206	protein involved in exopolysaccharide biosynthesis
E3166_RS17410	COG1294	oxidase, subunit
E3166_RS17415	COG1271	oxidase subunit
E3166_RS17420	COG1773	rubredoxin
E3166_RS17425	COG1999	signal sequence binding
E3166_RS17430	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E3166_RS17435	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E3166_RS17440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E3166_RS17445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E3166_RS17465	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS17480	COG2032	superoxide dismutase activity
E3166_RS17560	COG4372	Transposase
E3166_RS17565	COG3436	PFAM IS66 Orf2 family protein
E3166_RS17600	COG3772	lysozyme
E3166_RS17650	COG2207	Transcriptional regulator
E3166_RS17670	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E3166_RS17675	COG1403	HNH endonuclease
E3166_RS17705	COG1846	Transcriptional regulator
E3166_RS17710	COG1484	DNA-dependent DNA replication
E3166_RS17775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS17790	COG0670	Belongs to the BI1 family
E3166_RS17795	COG2920	part of a sulfur-relay system
E3166_RS17800	COG1254	Belongs to the acylphosphatase family
E3166_RS17815	COG1832	CoA-binding protein
E3166_RS17830	COG0210	DNA helicase
E3166_RS17835	COG3304	Inner membrane component domain
E3166_RS17840	COG1289	transmembrane transporter activity
E3166_RS17845	COG3070	regulator of competence-specific genes
E3166_RS17855	COG2885	chlorophyll binding
E3166_RS17855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3166_RS17865	COG1067	ATP-dependent peptidase activity
E3166_RS17875	COG3130	regulation of translation
E3166_RS17880	COG3009	Protein conserved in bacteria
E3166_RS17885	COG3008	intermembrane lipid transfer
E3166_RS17885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3166_RS17890	COG2995	paraquat-inducible protein a
E3166_RS17895	COG0488	(ABC) transporter
E3166_RS17905	COG3217	Mosc domain protein beta barrel domain protein
E3166_RS17905	COG0633	Ferredoxin
E3166_RS17925	COG3539	Fimbrial protein
E3166_RS17930	COG3539	Fimbrial protein
E3166_RS17935	COG3539	Fimbrial protein
E3166_RS17945	COG3121	Chaperone
E3166_RS17950	COG3539	Fimbrial protein
E3166_RS17955	COG0431	NADPH-dependent FMN reductase
E3166_RS17960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3166_RS17970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3166_RS17975	COG1116	anion transmembrane transporter activity
E3166_RS17980	COG0308	aminopeptidase N
E3166_RS17990	COG0017	Asparaginyl-tRNA synthetase
E3166_RS17995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3166_RS18000	COG1448	Aminotransferase
E3166_RS18005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3166_RS18010	COG3108	Peptidase M15
E3166_RS18015	COG2989	Protein conserved in bacteria
E3166_RS18025	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E3166_RS18035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3166_RS18040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E3166_RS18045	COG3173	Aminoglycoside phosphotransferase
E3166_RS18060	COG3214	Protein conserved in bacteria
E3166_RS18070	COG1132	(ABC) transporter
E3166_RS18075	COG2333	competence protein COMEC
E3166_RS18075	COG0658	competence protein
E3166_RS18085	COG0539	negative regulation of cytoplasmic translation
E3166_RS18095	COG0501	Belongs to the peptidase M48B family
E3166_RS18110	COG2323	membrane
E3166_RS18115	COG1944	ATP diphosphatase activity
E3166_RS18120	COG2116	formate transmembrane transporter activity
E3166_RS18125	COG1882	Formate acetyltransferase
E3166_RS18130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3166_RS18140	COG0531	amino acid
E3166_RS18150	COG1335	isochorismatase
E3166_RS18155	COG3302	dmso reductase anchor subunit
E3166_RS18160	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS18165	COG0243	molybdopterin cofactor binding
E3166_RS18175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3166_RS18185	COG1178	ABC-type Fe3 transport system permease component
E3166_RS18185	COG1674	ftsk spoiiie
E3166_RS18190	COG1522	sequence-specific DNA binding
E3166_RS18195	COG0492	ferredoxin-NADP+ reductase activity
E3166_RS18200	COG4988	ABC transporter
E3166_RS18205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3166_RS18225	COG0542	response to heat
E3166_RS18235	COG1278	Cold shock
E3166_RS18240	COG1136	(ABC) transporter
E3166_RS18240	COG0577	efflux transmembrane transporter activity
E3166_RS18245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS18250	COG2990	Protein conserved in bacteria
E3166_RS18255	COG3593	DNA synthesis involved in DNA repair
E3166_RS18260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3166_RS18265	COG2431	L-lysine efflux transmembrane transporter activity
E3166_RS18275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3166_RS18280	COG0028	Belongs to the TPP enzyme family
E3166_RS18285	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E3166_RS18290	COG0702	epimerase
E3166_RS18295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3166_RS18300	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3166_RS18320	COG1126	abc transporter atp-binding protein
E3166_RS18325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS18330	COG4215	(ABC) transporter
E3166_RS18335	COG4160	amino acid transport
E3166_RS18340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS18370	COG1177	transmembrane transport
E3166_RS18375	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3166_RS18380	COG3842	ATPase activity
E3166_RS18385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3166_RS18400	COG0778	Nitroreductase
E3166_RS18410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3166_RS18425	COG3226	Transcriptional regulator
E3166_RS18430	COG0738	Major facilitator superfamily
E3166_RS18435	COG0561	phosphatase activity
E3166_RS18450	COG0671	phosphoesterase, PA-phosphatase related
E3166_RS18455	COG1349	DNA-binding transcription factor activity
E3166_RS18460	COG1686	Belongs to the peptidase S11 family
E3166_RS18465	COG0625	glutathione transferase activity
E3166_RS18470	COG2133	pyrroloquinoline quinone binding
E3166_RS18495	COG2199	diguanylate cyclase activity
E3166_RS18500	COG2200	EAL domain
E3166_RS18510	COG0601	transmembrane transport
E3166_RS18515	COG0747	negative chemotaxis
E3166_RS18520	COG4172	Belongs to the ABC transporter superfamily
E3166_RS18530	COG0303	'Molybdopterin
E3166_RS18535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3166_RS18540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3166_RS18545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3166_RS18555	COG0561	phosphatase activity
E3166_RS18565	COG0488	(ABC) transporter
E3166_RS18570	COG1376	ErfK ybiS ycfS ynhG family protein
E3166_RS18575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3166_RS18580	COG1321	iron dependent repressor
E3166_RS18590	COG2194	sulfuric ester hydrolase activity
E3166_RS18595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3166_RS18605	COG5006	permease, DMT superfamily
E3166_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS18620	COG0765	amino acid transport
E3166_RS18625	COG1126	abc transporter atp-binding protein
E3166_RS18630	COG0668	transmembrane transport
E3166_RS18645	COG4774	siderophore transport
E3166_RS18655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3166_RS18665	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E3166_RS18670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3166_RS18675	COG1199	ATP-dependent helicase activity
E3166_RS18685	COG0513	Belongs to the DEAD box helicase family
E3166_RS18690	COG1309	transcriptional regulator
E3166_RS18700	COG1131	(ABC) transporter
E3166_RS18705	COG0842	Transport permease protein
E3166_RS18710	COG0842	Transport permease protein
E3166_RS18720	COG3568	Endonuclease Exonuclease Phosphatase
E3166_RS18725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3166_RS18730	COG0392	lysyltransferase activity
E3166_RS18735	COG0670	Belongs to the BI1 family
E3166_RS18740	COG0670	Belongs to the BI1 family
E3166_RS18745	COG0314	molybdopterin synthase activity
E3166_RS18750	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3166_RS18760	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3166_RS18770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3166_RS18780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E3166_RS18785	COG2226	methyltransferase
E3166_RS18800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3166_RS18805	COG1881	PFAM PEBP family protein
E3166_RS18845	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS18885	COG3772	lysozyme
E3166_RS19005	COG0582	viral genome integration into host DNA
E3166_RS19010	COG4677	pectinesterase activity
E3166_RS19015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3166_RS19020	COG0471	metal ion transport
E3166_RS19025	COG2828	Protein conserved in bacteria
E3166_RS19030	COG0583	DNA-binding transcription factor activity
E3166_RS19040	COG0561	phosphatase activity
E3166_RS19050	COG4149	molybdate abc transporter
E3166_RS19055	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3166_RS19065	COG3585	molybdate ion transport
E3166_RS19065	COG2005	Transcriptional regulator
E3166_RS19070	COG1119	ATPase activity
E3166_RS19075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3166_RS19080	COG1085	galactose-1-phosphate uridylyltransferase
E3166_RS19090	COG2017	converts alpha-aldose to the beta-anomer
E3166_RS19100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3166_RS19110	COG1230	cation diffusion facilitator family transporter
E3166_RS19115	COG3201	nicotinamide mononucleotide transporter
E3166_RS19120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3166_RS19155	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E3166_RS19160	COG2885	chlorophyll binding
E3166_RS19170	COG3064	Membrane
E3166_RS19175	COG0848	biopolymer transport protein
E3166_RS19180	COG0811	peptide transport
E3166_RS19185	COG0824	Thioesterase
E3166_RS19190	COG3790	cyd operon protein YbgE
E3166_RS19195	COG4890	Cyd operon protein YbgT
E3166_RS19200	COG1294	oxidase, subunit
E3166_RS19205	COG1271	oxidase subunit
E3166_RS19220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3166_RS19230	COG4865	methylaspartate mutase activity
E3166_RS19235	COG3799	methylaspartate ammonia-lyase activity
E3166_RS19250	COG1301	dicarboxylic acid transport
E3166_RS19255	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS19255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS19260	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E3166_RS19265	COG0583	DNA-binding transcription factor activity
E3166_RS19270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3166_RS19280	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3166_RS19285	COG0567	Dehydrogenase, E1 component
E3166_RS19290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3166_RS19295	COG1053	succinate dehydrogenase
E3166_RS19300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3166_RS19305	COG2009	succinate dehydrogenase
E3166_RS19315	COG0372	Belongs to the citrate synthase family
E3166_RS19320	COG3539	Fimbrial protein
E3166_RS19325	COG3188	usher protein
E3166_RS19330	COG3121	Chaperone
E3166_RS19335	COG3539	Fimbrial protein
E3166_RS19340	COG3180	Ammonia monooxygenase
E3166_RS19345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3166_RS19355	COG1984	allophanate hydrolase subunit 2
E3166_RS19360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3166_RS19365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3166_RS19370	COG3104	oligopeptide transport
E3166_RS19375	COG0415	Belongs to the DNA photolyase family
E3166_RS19380	COG3272	Protein of unknown function (DUF1722)
E3166_RS19385	COG5433	transposase activity
E3166_RS19400	COG3209	COG3209 Rhs family protein
E3166_RS19430	COG2205	protein histidine kinase activity
E3166_RS19435	COG0745	RESPONSE REGULATOR receiver
E3166_RS19445	COG1982	Orn Lys Arg decarboxylase major
E3166_RS19450	COG0531	amino acid
E3166_RS19455	COG0033	Phosphoglucomutase
E3166_RS19460	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E3166_RS19465	COG0596	Alpha beta hydrolase
E3166_RS19475	COG0716	FMN binding
E3166_RS19485	COG0735	belongs to the Fur family
E3166_RS19505	COG2190	(PTS) system
E3166_RS19505	COG1263	PTS System
E3166_RS19505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS19515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3166_RS19520	COG1846	Transcriptional regulator
E3166_RS19520	COG1940	carbohydrate kinase activity
E3166_RS19525	COG0647	UMP catabolic process
E3166_RS19530	COG0367	asparagine synthase
E3166_RS19570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3166_RS19580	COG1702	phosphate starvation-inducible protein PhoH
E3166_RS19590	COG4535	Mg2 and Co2 transporter CorC
E3166_RS19595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3166_RS19600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3166_RS19605	COG0765	amino acid transport
E3166_RS19610	COG0765	amino acid transport
E3166_RS19615	COG1126	abc transporter atp-binding protein
E3166_RS19625	COG0443	Heat shock 70 kDa protein
E3166_RS19640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3166_RS19645	COG2214	Heat shock protein DnaJ domain protein
E3166_RS19660	COG2888	peptidyl-tyrosine sulfation
E3166_RS19675	COG1466	dna polymerase III delta subunit
E3166_RS19685	COG0406	alpha-ribazole phosphatase activity
E3166_RS19690	COG0799	negative regulation of ribosome biogenesis
E3166_RS19700	COG0768	penicillin binding
E3166_RS19705	COG0772	Belongs to the SEDS family
E3166_RS19710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3166_RS19715	COG1686	Belongs to the peptidase S11 family
E3166_RS19730	COG0583	DNA-binding transcription factor activity
E3166_RS19740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3166_RS19745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3166_RS19765	COG3069	C4-dicarboxylate transmembrane transporter activity
E3166_RS19770	COG4565	transcriptional regulatory protein
E3166_RS19775	COG3290	protein histidine kinase activity
E3166_RS19780	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E3166_RS19790	COG2301	Belongs to the HpcH HpaI aldolase family
E3166_RS19795	COG3051	citrate lyase alpha subunit
E3166_RS19805	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E3166_RS19810	COG0471	metal ion transport
E3166_RS19815	COG3719	Belongs to the RNase T2 family
E3166_RS19820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3166_RS19825	COG1063	alcohol dehydrogenase
E3166_RS19830	COG0589	response to stress
E3166_RS19835	COG3634	alkyl hydroperoxide reductase activity
E3166_RS19840	COG0450	alkyl hydroperoxide reductase
E3166_RS19845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3166_RS19850	COG0583	DNA-binding transcription factor activity
E3166_RS19855	COG3969	phosphoadenosine phosphosulfate
E3166_RS19860	COG1475	DNA binding
E3166_RS19865	COG0436	Aminotransferase
E3166_RS19870	COG0371	Dehydrogenase
E3166_RS19875	COG2879	small protein
E3166_RS19880	COG1966	Carbon starvation protein
E3166_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS19895	COG1535	isochorismatase
E3166_RS19895	COG3433	isochorismatase activity
E3166_RS19900	COG1021	2,3-dihydroxybenzoate-AMP ligase
E3166_RS19905	COG1169	isochorismate synthase
E3166_RS19910	COG4592	Periplasmic binding protein
E3166_RS19920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3166_RS19925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3166_RS19930	COG1120	ATPase activity
E3166_RS19935	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3166_RS19940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3166_RS19940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E3166_RS19945	COG3251	PFAM MbtH domain protein
E3166_RS19950	COG2382	esterase
E3166_RS19955	COG4771	TonB-dependent receptor
E3166_RS19960	COG2977	Belongs to the P-Pant transferase superfamily
E3166_RS19985	COG2315	Protein conserved in bacteria
E3166_RS19990	COG0778	Nitroreductase
E3166_RS19995	COG0668	transmembrane transport
E3166_RS20000	COG1113	amino acid transport
E3166_RS20005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3166_RS20010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS20015	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS20020	COG1538	Outer membrane efflux protein
E3166_RS20025	COG0745	RESPONSE REGULATOR receiver
E3166_RS20030	COG5002	protein histidine kinase activity
E3166_RS20035	COG3501	Rhs element vgr protein
E3166_RS20045	COG4104	PAAR repeat-containing protein
E3166_RS20045	COG3209	COG3209 Rhs family protein
E3166_RS20055	COG3209	COG3209 Rhs family protein
E3166_RS20055	COG4104	PAAR repeat-containing protein
E3166_RS20065	COG5433	transposase activity
E3166_RS20070	COG1215	transferase activity, transferring glycosyl groups
E3166_RS20075	COG4783	chaperone-mediated protein folding
E3166_RS20085	COG2207	Transcriptional regulator
E3166_RS20095	COG2197	response regulator
E3166_RS20100	COG3539	Fimbrial protein
E3166_RS20105	COG3539	Fimbrial protein
E3166_RS20110	COG3188	usher protein
E3166_RS20115	COG3121	Chaperone
E3166_RS20120	COG3539	Fimbrial protein
E3166_RS20130	COG2501	S4 domain
E3166_RS20135	COG1988	membrane-bound metal-dependent
E3166_RS20145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3166_RS20155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3166_RS20160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3166_RS20165	COG0549	Belongs to the carbamate kinase family
E3166_RS20175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3166_RS20180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3166_RS20190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3166_RS20195	COG3257	ureidoglycine aminohydrolase activity
E3166_RS20200	COG1929	Belongs to the glycerate kinase type-1 family
E3166_RS20205	COG2233	PERMEase
E3166_RS20215	COG1953	Uracil, thiamine, allantoin
E3166_RS20220	COG2084	Dehydrogenase
E3166_RS20225	COG3622	Belongs to the hyi family
E3166_RS20230	COG3960	tartronate-semialdehyde synthase activity
E3166_RS20235	COG1414	Transcriptional regulator
E3166_RS20245	COG0583	DNA-binding transcription factor activity
E3166_RS20265	COG3209	COG3209 Rhs family protein
E3166_RS20270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3166_RS20275	COG4181	ATPase activity
E3166_RS20280	COG2755	lipolytic protein G-D-S-L family
E3166_RS20285	COG0300	oxidoreductase activity
E3166_RS20290	COG3118	belongs to the thioredoxin family
E3166_RS20295	COG0390	transport system, permease component
E3166_RS20300	COG4619	ABC transporter
E3166_RS20305	COG0330	HflC and HflK could
E3166_RS20310	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3166_RS20330	COG0789	Transcriptional regulator
E3166_RS20355	COG0531	amino acid
E3166_RS20360	COG2066	Belongs to the glutaminase family
E3166_RS20365	COG2217	Heavy metal translocating P-type atpase
E3166_RS20370	COG3093	addiction module antidote protein HigA
E3166_RS20375	COG3735	TraB family
E3166_RS20380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3166_RS20385	COG0737	Belongs to the 5'-nucleotidase family
E3166_RS20390	COG2223	nitrite transmembrane transporter activity
E3166_RS20395	COG4651	solute:proton antiporter activity
E3166_RS20395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3166_RS20400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS20435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3166_RS20445	COG2832	Protein of unknown function (DUF454)
E3166_RS20450	COG3923	Primosomal replication protein n
E3166_RS20460	COG3264	Mechanosensitive ion channel
E3166_RS20460	COG1196	nuclear chromosome segregation
E3166_RS20465	COG1309	transcriptional regulator
E3166_RS20470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3166_RS20475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3166_RS20490	COG0110	maltose O-acetyltransferase activity
E3166_RS20500	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3166_RS20505	COG5507	3-demethylubiquinone-9 3-methyltransferase
E3166_RS20515	COG3695	enzyme binding
E3166_RS20520	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E3166_RS20525	COG1946	Acyl-CoA thioesterase
E3166_RS20530	COG0004	ammonium transporteR
E3166_RS20535	COG0347	Belongs to the P(II) protein family
E3166_RS20540	COG1132	(ABC) transporter
E3166_RS20545	COG1132	(ABC) transporter
E3166_RS20550	COG1522	sequence-specific DNA binding
E3166_RS20560	COG4533	DNA binding
E3166_RS20570	COG0824	Thioesterase
E3166_RS20575	COG1555	photosystem II stabilization
E3166_RS20580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3166_RS20585	COG0776	regulation of translation
E3166_RS20590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3166_RS20610	COG0271	Belongs to the BolA IbaG family
E3166_RS20615	COG3056	Lipoprotein
E3166_RS20620	COG2223	nitrite transmembrane transporter activity
E3166_RS20625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3166_RS20630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3166_RS20635	COG1845	cytochrome c oxidase, subunit III
E3166_RS20640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3166_RS20650	COG2814	Major facilitator Superfamily
E3166_RS20660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3166_RS20665	COG0693	protein deglycase activity
E3166_RS20680	COG0142	geranyltranstransferase activity
E3166_RS20690	COG0667	Aldo Keto reductase
E3166_RS20700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3166_RS20705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3166_RS20720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3166_RS20720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3166_RS20730	COG4238	major outer membrane lipoprotein
E3166_RS20735	COG3248	Nucleoside-binding outer membrane protein
E3166_RS20740	COG1403	HNH endonuclease
E3166_RS20750	COG3609	addiction module antidote protein, CC2985 family
E3166_RS20755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3166_RS20760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3166_RS20765	COG1862	Preprotein translocase
E3166_RS20790	COG0366	Alpha amylase catalytic
E3166_RS20795	COG1113	amino acid transport
E3166_RS20800	COG1114	Component of the transport system for branched-chain amino acids
E3166_RS20805	COG5002	protein histidine kinase activity
E3166_RS20810	COG0745	RESPONSE REGULATOR receiver
E3166_RS20815	COG0420	3'-5' exonuclease activity
E3166_RS20820	COG0419	ATPase involved in DNA repair
E3166_RS20825	COG2814	Major facilitator Superfamily
E3166_RS20830	COG1940	carbohydrate kinase activity
E3166_RS20855	COG4126	flavin adenine dinucleotide binding
E3166_RS20875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3166_RS20880	COG3706	GGDEF domain
E3166_RS20890	COG1785	Belongs to the alkaline phosphatase family
E3166_RS20905	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3166_RS20925	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E3166_RS20930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3166_RS20935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3166_RS20940	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS20945	COG0113	porphobilinogen synthase activity
E3166_RS20950	COG2175	clavaminate synthase activity
E3166_RS20955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3166_RS20960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E3166_RS20965	COG4521	taurine ABC transporter
E3166_RS20980	COG2271	Major facilitator Superfamily
E3166_RS20985	COG1840	ABC-type Fe3 transport system, periplasmic component
E3166_RS20995	COG3842	ATPase activity
E3166_RS21010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3166_RS21015	COG3122	Protein conserved in bacteria
E3166_RS21020	COG2814	Major facilitator Superfamily
E3166_RS21025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3166_RS21040	COG0596	Alpha beta hydrolase
E3166_RS21055	COG1414	Transcriptional regulator
E3166_RS21060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3166_RS21070	COG1609	Transcriptional regulator
E3166_RS21075	COG3250	beta-galactosidase activity
E3166_RS21080	COG2223	nitrite transmembrane transporter activity
E3166_RS21085	COG0110	maltose O-acetyltransferase activity
E3166_RS21090	COG2807	transmembrane transport
E3166_RS21100	COG0288	reversible hydration of carbon dioxide
E3166_RS21105	COG0583	DNA-binding transcription factor activity
E3166_RS21110	COG0402	S-adenosylhomocysteine deaminase activity
E3166_RS21115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3166_RS21120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3166_RS21125	COG2079	MmgE PrpD family protein
E3166_RS21130	COG0372	Belongs to the citrate synthase family
E3166_RS21135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3166_RS21140	COG3829	transcription factor binding
E3166_RS21150	COG1280	lysine exporter protein (LysE YggA)
E3166_RS21165	COG1064	alcohol dehydrogenase
E3166_RS21175	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS21180	COG1129	ABC transporter
E3166_RS21185	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS21195	COG0402	S-adenosylhomocysteine deaminase activity
E3166_RS21200	COG0549	Belongs to the carbamate kinase family
E3166_RS21210	COG1304	FMN binding
E3166_RS21215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3166_RS21225	COG0666	response to abiotic stimulus
E3166_RS21240	COG2771	luxR family
E3166_RS21240	COG2200	EAL domain
E3166_RS21250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3166_RS21285	COG2771	luxR family
E3166_RS21285	COG2200	EAL domain
E3166_RS21310	COG1556	Lactate utilization protein
E3166_RS21315	COG1139	Iron-sulfur cluster binding protein
E3166_RS21320	COG0247	lactate metabolic process
E3166_RS21325	COG2207	Transcriptional regulator
E3166_RS21330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3166_RS21340	COG3059	membrane
E3166_RS21345	COG0656	L-ascorbic acid biosynthetic process
E3166_RS21350	COG3708	Transcriptional regulator
E3166_RS21350	COG2207	Transcriptional regulator
E3166_RS21355	COG1388	LysM domain
E3166_RS21380	COG0583	DNA-binding transcription factor activity
E3166_RS21385	COG1073	alpha beta
E3166_RS21410	COG4372	Transposase
E3166_RS21415	COG3436	PFAM IS66 Orf2 family protein
E3166_RS21455	COG3188	usher protein
E3166_RS21465	COG3121	Chaperone
E3166_RS21470	COG0727	PFAM Uncharacterised protein family (UPF0153)
E3166_RS21475	COG3477	response to acidic pH
E3166_RS21480	COG2080	2 iron, 2 sulfur cluster binding
E3166_RS21485	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3166_RS21490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3166_RS21495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3166_RS21510	COG0583	DNA-binding transcription factor activity
E3166_RS21520	COG4221	oxidoreductase activity
E3166_RS21525	COG0583	DNA-binding transcription factor activity
E3166_RS21610	COG1196	nuclear chromosome segregation
E3166_RS21615	COG3596	GTP binding
E3166_RS21620	COG2378	regulation of single-species biofilm formation
E3166_RS21655	COG2003	Belongs to the UPF0758 family
E3166_RS21700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E3166_RS21720	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3166_RS21725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3166_RS21730	COG1690	Belongs to the RtcB family
E3166_RS21735	COG0454	-acetyltransferase
E3166_RS21745	COG2161	toxin-antitoxin pair type II binding
E3166_RS21750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3166_RS21770	COG0791	NLP P60 protein
E3166_RS21775	COG3077	Addiction module antitoxin, RelB DinJ family
E3166_RS21780	COG3041	Addiction module toxin RelE StbE family
E3166_RS21785	COG3034	peptidoglycan biosynthetic process
E3166_RS21790	COG0121	glutamine amidotransferase
E3166_RS21800	COG1960	acyl-CoA dehydrogenase activity
E3166_RS21810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3166_RS21815	COG5433	transposase activity
E3166_RS21830	COG3209	COG3209 Rhs family protein
E3166_RS21835	COG5433	transposase activity
E3166_RS21845	COG3209	COG3209 Rhs family protein
E3166_RS21855	COG3209	COG3209 Rhs family protein
E3166_RS21860	COG3501	Rhs element vgr protein
E3166_RS21975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3166_RS21985	COG2226	methyltransferase
E3166_RS21995	COG1388	LysM domain
E3166_RS21995	COG0741	lytic transglycosylase activity
E3166_RS22000	COG2226	methyltransferase
E3166_RS22010	COG0583	DNA-binding transcription factor activity
E3166_RS22015	COG0656	L-ascorbic acid biosynthetic process
E3166_RS22050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3166_RS22055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3166_RS22060	COG2011	ABC-type metal ion transport system permease component
E3166_RS22065	COG1464	Belongs to the NlpA lipoprotein family
E3166_RS22075	COG1720	tRNA m6t6A37 methyltransferase activity
E3166_RS22085	COG0791	NLP P60 protein
E3166_RS22090	COG3015	lipoprotein NlpE involved in copper resistance
E3166_RS22095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3166_RS22100	COG4681	YaeQ
E3166_RS22110	COG4568	rho-dependent transcription termination
E3166_RS22115	COG0037	tRNA processing
E3166_RS22120	COG0346	lactoylglutathione lyase activity
E3166_RS22135	COG0587	DNA-directed DNA polymerase activity
E3166_RS22160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3166_RS22165	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E3166_RS22175	COG0750	zinc metalloprotease
E3166_RS22180	COG0575	Belongs to the CDS family
E3166_RS22185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3166_RS22190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3166_RS22215	COG0024	Methionine aminopeptidase
E3166_RS22235	COG3835	regulator
E3166_RS22240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3166_RS22255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3166_RS22260	COG2860	membrane
E3166_RS22285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3166_RS22290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3166_RS22295	COG1120	ATPase activity
E3166_RS22305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3166_RS22310	COG1643	Atp-dependent helicase
E3166_RS22315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E3166_RS22325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3166_RS22330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3166_RS22335	COG0617	tRNA 3'-terminal CCA addition
E3166_RS22340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3166_RS22350	COG3121	Chaperone
E3166_RS22355	COG3188	usher protein
E3166_RS22360	COG3539	Fimbrial protein
E3166_RS22365	COG3539	Fimbrial protein
E3166_RS22390	COG5464	transposase or invertase
E3166_RS22400	COG0726	polysaccharide deacetylase
E3166_RS22405	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS22410	COG0842	Transport permease protein
E3166_RS22415	COG1131	(ABC) transporter
E3166_RS22420	COG0288	reversible hydration of carbon dioxide
E3166_RS22425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E3166_RS22430	COG4993	Dehydrogenase
E3166_RS22435	COG2132	Multicopper oxidase
E3166_RS22460	COG1049	propionate catabolic process, 2-methylcitrate cycle
E3166_RS22465	COG3064	Membrane
E3166_RS22470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3166_RS22475	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3166_RS22480	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3166_RS22485	COG2186	Transcriptional regulator
E3166_RS22490	COG1113	amino acid transport
E3166_RS22495	COG3725	Membrane protein required for beta-lactamase induction
E3166_RS22500	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3166_RS22505	COG0157	Belongs to the NadC ModD family
E3166_RS22510	COG4969	Belongs to the N-Me-Phe pilin family
E3166_RS22515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3166_RS22520	COG1459	type II secretion system
E3166_RS22530	COG0237	dephospho-CoA kinase activity
E3166_RS22545	COG0494	nUDIX hydrolase
E3166_RS22565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3166_RS22570	COG0849	cell division
E3166_RS22575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3166_RS22580	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3166_RS22595	COG0772	Belongs to the SEDS family
E3166_RS22600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3166_RS22610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3166_RS22615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3166_RS22620	COG0768	penicillin binding
E3166_RS22625	COG3116	cell division
E3166_RS22640	COG1609	Transcriptional regulator
E3166_RS22650	COG0440	acetolactate synthase activity
E3166_RS22655	COG0028	Belongs to the TPP enzyme family
E3166_RS22660	COG0583	DNA-binding transcription factor activity
E3166_RS22675	COG0473	3-isopropylmalate dehydrogenase activity
E3166_RS22695	COG4533	DNA binding
E3166_RS22705	COG4143	(ABC) transporter
E3166_RS22710	COG1178	ABC-type Fe3 transport system permease component
E3166_RS22715	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E3166_RS22720	COG0586	Pfam SNARE associated Golgi protein
E3166_RS22725	COG4977	sequence-specific DNA binding
E3166_RS22740	COG0235	Class ii aldolase
E3166_RS22745	COG0417	DNA replication proofreading
E3166_RS22755	COG0564	pseudouridine synthase activity
E3166_RS22765	COG1357	PFAM Pentapeptide repeats (8 copies)
E3166_RS22770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3166_RS22775	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3166_RS22780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3166_RS22815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3166_RS22830	COG2271	Major facilitator Superfamily
E3166_RS22835	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E3166_RS22840	COG0644	oxidoreductase
E3166_RS22890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3166_RS22895	COG0505	Belongs to the CarA family
E3166_RS22915	COG1047	Peptidyl-prolyl cis-trans
E3166_RS22930	COG0196	riboflavin kinase activity
E3166_RS22955	COG3121	Chaperone
E3166_RS22960	COG3188	usher protein
E3166_RS22970	COG0583	DNA-binding transcription factor activity
E3166_RS23000	COG4735	regulation of single-species biofilm formation
E3166_RS23005	COG1584	GPR1 FUN34 yaaH family protein
E3166_RS23010	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3166_RS23015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3166_RS23020	COG1115	amino acid carrier protein
E3166_RS23035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3166_RS23045	COG0527	aspartate kinase activity
E3166_RS23045	COG0460	homoserine dehydrogenase
E3166_RS23055	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E3166_RS23065	COG0745	RESPONSE REGULATOR receiver
E3166_RS23070	COG4452	Inner membrane protein CreD
E3166_RS23075	COG2205	protein histidine kinase activity
E3166_RS23080	COG0745	RESPONSE REGULATOR receiver
E3166_RS23085	COG3045	CreA protein
E3166_RS23090	COG2207	Transcriptional regulator
E3166_RS23090	COG3708	Transcriptional regulator
E3166_RS23100	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
E3166_RS23110	COG0741	lytic transglycosylase activity
E3166_RS23115	COG0488	(ABC) transporter
E3166_RS23125	COG1056	cytidyltransferase-related domain
E3166_RS23125	COG3172	ATPase kinase involved in NAD metabolism
E3166_RS23130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3166_RS23135	COG0560	Phosphoserine phosphatase
E3166_RS23140	COG3726	membrane protein affecting hemolysin expression
E3166_RS23145	COG0095	Lipoate-protein ligase
E3166_RS23145	COG3726	membrane protein affecting hemolysin expression
E3166_RS23180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3166_RS23185	COG0084	hydrolase, TatD family'
E3166_RS23190	COG4667	esterase of the alpha-beta hydrolase superfamily
E3166_RS23200	COG2823	Periplasmic or secreted lipoprotein
E3166_RS23210	COG1011	Hydrolase
E3166_RS23215	COG0456	acetyltransferase
E3166_RS23220	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E3166_RS23240	COG4114	ferric iron reductase
E3166_RS23245	COG2197	response regulator
E3166_RS23250	COG2197	response regulator
E3166_RS23255	COG2966	Psort location CytoplasmicMembrane, score
E3166_RS23270	COG1484	DNA-dependent DNA replication
E3166_RS23285	COG1063	alcohol dehydrogenase
E3166_RS23290	COG1802	Transcriptional regulator
E3166_RS23295	COG2271	Major facilitator Superfamily
E3166_RS23300	COG0840	transmembrane signaling receptor activity
E3166_RS23310	COG1966	Carbon starvation protein
E3166_RS23315	COG2879	small protein
E3166_RS23320	COG0523	cobalamin synthesis protein
E3166_RS23345	COG0732	type I restriction modification DNA specificity domain
E3166_RS23365	COG5457	Domain of unknown function (DUF1127)
E3166_RS23370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3166_RS23380	COG5464	transposase or invertase
E3166_RS23385	COG2814	Major facilitator Superfamily
E3166_RS23390	COG2733	membrane
E3166_RS23395	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E3166_RS23400	COG1924	4 iron, 4 sulfur cluster binding
E3166_RS23415	COG3204	pilus organization
E3166_RS23420	COG0477	Major facilitator Superfamily
E3166_RS23435	COG3366	ferrous iron transmembrane transporter activity
E3166_RS23440	COG0700	Nucleoside recognition
E3166_RS23445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3166_RS23470	COG2186	Transcriptional regulator
E3166_RS23475	COG0246	Mannitol dehydrogenase
E3166_RS23485	COG2610	gluconate transmembrane transporter activity
E3166_RS23490	COG3539	Fimbrial protein
E3166_RS23495	COG3539	Fimbrial protein
E3166_RS23500	COG3539	Fimbrial protein
E3166_RS23505	COG3188	usher protein
E3166_RS23510	COG3121	Chaperone
E3166_RS23515	COG3539	Fimbrial protein
E3166_RS23520	COG3539	Fimbrial protein
E3166_RS23525	COG4974	Belongs to the 'phage' integrase family
E3166_RS23530	COG0582	viral genome integration into host DNA
E3166_RS23535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3166_RS23540	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E3166_RS23555	COG0210	DNA helicase
E3166_RS23560	COG1205	dead DEAH box helicase
E3166_RS23560	COG1111	helicase
E3166_RS23570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3166_RS23615	COG0582	viral genome integration into host DNA
E3166_RS23665	COG1064	alcohol dehydrogenase
E3166_RS23670	COG0433	COG0433 Predicted ATPase
E3166_RS23675	COG0795	lipopolysaccharide-transporting ATPase activity
E3166_RS23680	COG0795	lipopolysaccharide-transporting ATPase activity
E3166_RS23690	COG2927	DNA polymerase III (CHI subunit)
E3166_RS23700	COG4269	membrane
E3166_RS23705	COG0456	acetyltransferase
E3166_RS23710	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E3166_RS23715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3166_RS23725	COG2731	YhcH YjgK YiaL family protein
E3166_RS23730	COG1309	transcriptional regulator
E3166_RS23735	COG1028	Short-chain dehydrogenase reductase Sdr
E3166_RS23740	COG0251	oxidation-reduction process
E3166_RS23760	COG0251	oxidation-reduction process
E3166_RS23765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3166_RS23775	COG1609	Transcriptional regulator
E3166_RS23780	COG1263	PTS System
E3166_RS23780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3166_RS23785	COG0366	Alpha amylase catalytic
E3166_RS23790	COG1328	CTP reductase activity
E3166_RS23795	COG0602	queuosine metabolic process
E3166_RS23800	COG3783	Cytochrome b(562)
E3166_RS23805	COG0312	modulator of DNA gyrase
E3166_RS23815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3166_RS23825	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS23830	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS23835	COG1129	ABC transporter
E3166_RS23840	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS23845	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3166_RS23850	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3166_RS23855	COG2336	PFAM SpoVT AbrB
E3166_RS23860	COG2105	PFAM AIG2 family protein
E3166_RS23865	COG2911	Protein conserved in bacteria
E3166_RS23870	COG0729	surface antigen
E3166_RS23880	COG1253	flavin adenine dinucleotide binding
E3166_RS23890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E3166_RS23900	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3166_RS23905	COG0737	Belongs to the 5'-nucleotidase family
E3166_RS23910	COG1733	regulation of RNA biosynthetic process
E3166_RS23915	COG0702	epimerase
E3166_RS23920	COG0697	spore germination
E3166_RS23930	COG1113	amino acid transport
E3166_RS23935	COG0545	Peptidyl-prolyl cis-trans isomerase
E3166_RS23940	COG3061	Opacity-associated protein A
E3166_RS23950	COG0675	Transposase, IS605 OrfB family
E3166_RS23975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3166_RS24010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS24015	COG3414	Phosphotransferase system galactitol-specific IIB component
E3166_RS24020	COG3037	sugar-specific permease SgaT UlaA
E3166_RS24035	COG1073	alpha beta
E3166_RS24040	COG3650	response to hydrogen peroxide
E3166_RS24050	COG1960	acyl-CoA dehydrogenase activity
E3166_RS24055	COG0754	glutathionylspermidine amidase activity
E3166_RS24060	COG5463	Belongs to the UPF0441 family
E3166_RS24065	COG3766	membrane
E3166_RS24075	COG1842	Phage shock protein A
E3166_RS24080	COG3789	protein conserved in bacteria
E3166_RS24085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3166_RS24090	COG0557	exoribonuclease II activity
E3166_RS24105	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E3166_RS24110	COG0330	HflC and HflK could
E3166_RS24115	COG0330	HflC and HflK could
E3166_RS24120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3166_RS24140	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3166_RS24145	COG0802	atpase or kinase
E3166_RS24150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3166_RS24150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3166_RS24180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3166_RS24195	COG1511	domain protein
E3166_RS24195	COG3264	Mechanosensitive ion channel
E3166_RS24200	COG0531	amino acid
E3166_RS24210	COG1053	succinate dehydrogenase
E3166_RS24215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3166_RS24230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3166_RS24235	COG3040	lipid binding
E3166_RS24240	COG2076	Multidrug Resistance protein
E3166_RS24245	COG5510	response to toxic substance
E3166_RS24250	COG5510	response to toxic substance
E3166_RS24260	COG1509	lysine 2,3-aminomutase activity
E3166_RS24285	COG0531	amino acid
E3166_RS24290	COG3030	protein affecting phage T7 exclusion by the F plasmid
E3166_RS24295	COG1027	Aspartate ammonia-lyase
E3166_RS24300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3166_RS24310	COG4232	protein-disulfide reductase activity
E3166_RS24315	COG1309	transcriptional regulator
E3166_RS24325	COG3710	Transcriptional regulator
E3166_RS24330	COG0531	amino acid
E3166_RS24335	COG1982	Orn Lys Arg decarboxylase major
E3166_RS24340	COG3104	oligopeptide transport
E3166_RS24345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3166_RS24360	COG2388	GCN5-related N-acetyl-transferase
E3166_RS24365	COG3592	Divergent 4Fe-4S mono-cluster
E3166_RS24370	COG3290	protein histidine kinase activity
E3166_RS24375	COG4565	transcriptional regulatory protein
E3166_RS24380	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E3166_RS24385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS24385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3166_RS24390	COG3647	Membrane
E3166_RS24395	COG2211	Major facilitator Superfamily
E3166_RS24400	COG1486	melibiose metabolic process
E3166_RS24405	COG2169	Transcriptional regulator
E3166_RS24410	COG1982	Orn Lys Arg decarboxylase major
E3166_RS24415	COG2207	Transcriptional regulator
E3166_RS24420	COG0531	amino acid
E3166_RS24425	COG2194	sulfuric ester hydrolase activity
E3166_RS24430	COG0745	RESPONSE REGULATOR receiver
E3166_RS24435	COG0642	Histidine kinase
E3166_RS24445	COG0477	Major facilitator Superfamily
E3166_RS24455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3166_RS24460	COG2824	Alkylphosphonate utilization operon protein PhnA
E3166_RS24465	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E3166_RS24470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E3166_RS24475	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E3166_RS24480	COG3639	organic phosphonate transmembrane transporter activity
E3166_RS24485	COG2188	Transcriptional regulator
E3166_RS24490	COG3624	Phosphonate C-P lyase system protein PhnG
E3166_RS24495	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E3166_RS24500	COG3626	phosphonate metabolism
E3166_RS24505	COG3627	carbon phosphorus lyase activity
E3166_RS24510	COG4107	phosphonate C-P lyase system protein PhnK
E3166_RS24515	COG4778	phosphonate C-P lyase system protein PhnL
E3166_RS24520	COG3454	Phosphonate metabolism
E3166_RS24525	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E3166_RS24530	COG0456	acetyltransferase
E3166_RS24535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3166_RS24550	COG1129	ABC transporter
E3166_RS24555	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS24575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS24585	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E3166_RS24595	COG1566	PFAM secretion protein HlyD family protein
E3166_RS24615	COG1538	Outer membrane efflux protein
E3166_RS24625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3166_RS24630	COG1301	dicarboxylic acid transport
E3166_RS24635	COG4235	cytochrome complex assembly
E3166_RS24640	COG3088	subunit of a heme lyase
E3166_RS24645	COG1138	Cytochrome C-type biogenesis protein
E3166_RS24650	COG3301	Polysulphide reductase, NrfD
E3166_RS24655	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS24660	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E3166_RS24670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3166_RS24675	COG3162	membrane
E3166_RS24685	COG1357	PFAM Pentapeptide repeats (8 copies)
E3166_RS24690	COG0025	NhaP-type Na H and K H
E3166_RS24695	COG2252	PERMEase
E3166_RS24700	COG0789	Transcriptional regulator
E3166_RS24705	COG2207	Transcriptional regulator
E3166_RS24710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3166_RS24720	COG0629	single-stranded DNA binding
E3166_RS24725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3166_RS24730	COG2315	Protein conserved in bacteria
E3166_RS24735	COG0432	Pfam Uncharacterised protein family UPF0047
E3166_RS24740	COG3700	Belongs to the class B bacterial acid phosphatase family
E3166_RS24750	COG1448	Aminotransferase
E3166_RS24755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3166_RS24760	COG0305	Participates in initiation and elongation during chromosome replication
E3166_RS24765	COG0604	alcohol dehydrogenase
E3166_RS24775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3166_RS24815	COG5301	cellulose 1,4-beta-cellobiosidase activity
E3166_RS24835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E3166_RS24875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3166_RS24885	COG0735	belongs to the Fur family
E3166_RS24890	COG3237	CsbD-like
E3166_RS24895	COG0534	Mate efflux family protein
E3166_RS24905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3166_RS24925	COG1357	PFAM Pentapeptide repeats (8 copies)
E3166_RS24940	COG3842	ATPase activity
E3166_RS24945	COG2182	Extracellular solute-binding protein
E3166_RS24950	COG1175	transmembrane transport
E3166_RS24955	COG3833	ABC-type maltose transport systems, permease component
E3166_RS24960	COG2814	Major facilitator Superfamily
E3166_RS24960	COG0477	Major facilitator Superfamily
E3166_RS24980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3166_RS25005	COG0527	aspartate kinase activity
E3166_RS25015	COG1187	pseudouridine synthase activity
E3166_RS25060	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3166_RS25065	COG0646	methionine synthase
E3166_RS25065	COG1410	methionine synthase
E3166_RS25070	COG1414	Transcriptional regulator
E3166_RS25085	COG2224	Isocitrate lyase
E3166_RS25090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3166_RS25100	COG0456	acetyltransferase
E3166_RS25130	COG0151	Belongs to the GarS family
E3166_RS25135	COG2204	response regulator
E3166_RS25140	COG4191	Histidine kinase
E3166_RS25145	COG3678	ATP-independent chaperone mediated protein folding
E3166_RS25160	COG3068	Protein conserved in bacteria
E3166_RS25195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3166_RS25200	COG2104	thiamine diphosphate biosynthetic process
E3166_RS25205	COG2022	thiamine diphosphate biosynthetic process
E3166_RS25210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3166_RS25250	COG0250	Participates in transcription elongation, termination and antitermination
E3166_RS25255	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3166_RS25290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E3166_RS25290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E3166_RS25295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3166_RS25320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3166_RS25325	COG4206	TonB-dependent receptor
E3166_RS25330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3166_RS25340	COG1309	transcriptional regulator
E3166_RS25345	COG0477	Major facilitator Superfamily
E3166_RS25350	COG1473	amidohydrolase
E3166_RS25360	COG0583	DNA-binding transcription factor activity
E3166_RS25375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3166_RS25390	COG2194	sulfuric ester hydrolase activity
E3166_RS25395	COG2207	Transcriptional regulator
E3166_RS25400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS25405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E3166_RS25410	COG1882	Formate acetyltransferase
E3166_RS25415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS25420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS25425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS25425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS25425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3166_RS25430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3166_RS25435	COG0371	Dehydrogenase
E3166_RS25440	COG3738	Protein conserved in bacteria
E3166_RS25445	COG0697	spore germination
E3166_RS25455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3166_RS25460	COG0460	homoserine dehydrogenase
E3166_RS25460	COG0527	aspartate kinase activity
E3166_RS25465	COG0626	cystathionine gamma-synthase activity
E3166_RS25475	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E3166_RS25490	COG3209	COG3209 Rhs family protein
E3166_RS25500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3166_RS25505	COG1609	Transcriptional regulator
E3166_RS25510	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3166_RS25525	COG1575	Belongs to the MenA family. Type 1 subfamily
E3166_RS25550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3166_RS25560	COG1494	fructose-1,6-bisphosphatase
E3166_RS25570	COG0589	response to stress
E3166_RS25575	COG3691	Protein conserved in bacteria
E3166_RS25580	COG3152	Membrane
E3166_RS25600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3166_RS25615	COG3678	ATP-independent chaperone mediated protein folding
E3166_RS25620	COG0745	RESPONSE REGULATOR receiver
E3166_RS25625	COG2205	protein histidine kinase activity
E3166_RS25630	COG2258	MOSC domain
E3166_RS25640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3166_RS25650	COG1917	Cupin 2, conserved barrel domain protein
E3166_RS25650	COG4977	sequence-specific DNA binding
E3166_RS25685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS25690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS25690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3166_RS25695	COG1363	Peptidase, m42
E3166_RS25700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3166_RS25700	COG3711	transcriptional antiterminator
E3166_RS25720	COG0437	4 iron, 4 sulfur cluster binding
E3166_RS25725	COG2864	formate dehydrogenase
E3166_RS25735	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3166_RS25740	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3166_RS25755	COG0456	acetyltransferase
E3166_RS25770	COG1011	Hydrolase
E3166_RS25775	COG1349	DNA-binding transcription factor activity
E3166_RS25780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS25785	COG2084	Dehydrogenase
E3166_RS25790	COG3684	Belongs to the aldolase LacD family
E3166_RS25795	COG2942	2-epimerase
E3166_RS25800	COG2017	converts alpha-aldose to the beta-anomer
E3166_RS25810	COG1501	Belongs to the glycosyl hydrolase 31 family
E3166_RS25815	COG2211	Major facilitator Superfamily
E3166_RS25820	COG2211	Major facilitator Superfamily
E3166_RS25825	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3166_RS25830	COG2271	Major facilitator Superfamily
E3166_RS25840	COG2188	Transcriptional regulator
E3166_RS25850	COG0174	glutamine synthetase
E3166_RS25855	COG3852	Histidine kinase
E3166_RS25860	COG2204	response regulator
E3166_RS25870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3166_RS25875	COG3078	GTPase activator activity
E3166_RS25885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3166_RS25885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3166_RS25890	COG0204	Acyl-transferase
E3166_RS25895	COG5339	Protein conserved in bacteria
E3166_RS25900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3166_RS25905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3166_RS25910	COG3084	Protein conserved in bacteria
E3166_RS25915	COG0746	molybdenum cofactor guanylyltransferase activity
E3166_RS25920	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3166_RS25950	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E3166_RS25955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3166_RS25960	COG1739	Uncharacterized protein family UPF0029
E3166_RS25975	COG0183	Belongs to the thiolase family
E3166_RS25980	COG0543	2 iron, 2 sulfur cluster binding
E3166_RS25985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3166_RS25990	COG0250	Participates in transcription elongation, termination and antitermination
E3166_RS25995	COG0084	hydrolase, TatD family'
E3166_RS26000	COG0805	protein transport
E3166_RS26005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3166_RS26010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3166_RS26020	COG3165	ubiquinone biosynthetic process from chorismate
E3166_RS26030	COG1322	Protein conserved in bacteria
E3166_RS26035	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E3166_RS26040	COG0412	Dienelactone hydrolase
E3166_RS26050	COG0583	DNA-binding transcription factor activity
E3166_RS26055	COG0697	spore germination
E3166_RS26060	COG0561	phosphatase activity
E3166_RS26065	COG2267	carboxylic ester hydrolase activity
E3166_RS26070	COG1280	lysine exporter protein (LysE YggA)
E3166_RS26075	COG1280	lysine exporter protein (LysE YggA)
E3166_RS26080	COG0514	ATP-dependent DNA helicase (RecQ)
E3166_RS26085	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E3166_RS26090	COG2050	protein possibly involved in aromatic compounds catabolism
E3166_RS26095	COG2962	Rard protein
E3166_RS26120	COG0598	Magnesium transport protein CorA
E3166_RS26125	COG3698	Phosphodiester glycosidase
E3166_RS26130	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E3166_RS26135	COG0210	DNA helicase
E3166_RS26140	COG1011	Hydrolase
E3166_RS26150	COG3159	Protein conserved in bacteria
E3166_RS26160	COG5567	small periplasmic lipoprotein
E3166_RS26170	COG3072	Adenylate cyclase
E3166_RS26180	COG1587	Uroporphyrinogen-III synthase
E3166_RS26185	COG2959	enzyme of heme biosynthesis
E3166_RS26190	COG3071	HemY protein
E3166_RS26195	COG3119	arylsulfatase activity
E3166_RS26200	COG0641	radical SAM
E3166_RS26230	COG1113	amino acid transport
E3166_RS26250	COG2244	polysaccharide biosynthetic process
E3166_RS26255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3166_RS26260	COG0456	acetyltransferase
E3166_RS26265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3166_RS26270	COG1088	dTDP-glucose 4,6-dehydratase activity
E3166_RS26275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3166_RS26280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3166_RS26285	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E3166_RS26290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3166_RS26295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3166_RS26305	COG3118	belongs to the thioredoxin family
E3166_RS26320	COG0210	DNA helicase
E3166_RS26325	COG3692	DNA binding
E3166_RS26330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3166_RS26340	COG0583	DNA-binding transcription factor activity
E3166_RS26345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3166_RS26355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3166_RS26360	COG3978	acetolactate synthase activity
E3166_RS26385	COG3085	chromosome segregation
E3166_RS26425	COG2186	Transcriptional regulator
E3166_RS26430	COG0477	Major facilitator Superfamily
E3166_RS26435	COG1609	Transcriptional regulator
E3166_RS26440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3166_RS26445	COG1879	ABC-type sugar transport system periplasmic component
E3166_RS26450	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3166_RS26455	COG1129	ABC transporter
E3166_RS26465	COG3158	transport of potassium into the cell
E3166_RS26485	COG1522	sequence-specific DNA binding
E3166_RS26490	COG0716	FMN binding
E3166_RS26525	COG4680	protein conserved in bacteria
E3166_RS26565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3166_RS26600	COG3736	Type IV secretory pathway, component VirB8
E3166_RS26765	COG3468	outer membrane autotransporter barrel domain protein
E3166_RS26775	COG3436	PFAM IS66 Orf2 family protein
E3166_RS26780	COG4372	Transposase
E3166_RS26790	COG0726	polysaccharide deacetylase
E3166_RS26795	COG0297	glycogen (starch) synthase activity
E3166_RS26800	COG2194	sulfuric ester hydrolase activity
E3166_RS26805	COG1560	Kdo2-lipid A biosynthetic process
E3166_RS26905	COG2274	protein secretion by the type I secretion system
E3166_RS27070	COG1475	DNA binding
E3166_RS27155	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E3166_RS27165	COG1525	nuclease