locus-tag	class	description
I3M_RS00015	COG2274	protein secretion by the type I secretion system
I3M_RS00100	COG3436	PFAM IS66 Orf2 family protein
I3M_RS00105	COG4372	Transposase
I3M_RS00225	COG4372	Transposase
I3M_RS00230	COG3436	PFAM IS66 Orf2 family protein
I3M_RS00415	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3M_RS00430	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS00460	COG3436	PFAM IS66 Orf2 family protein
I3M_RS00465	COG4372	Transposase
I3M_RS00485	COG3436	PFAM IS66 Orf2 family protein
I3M_RS00490	COG4372	Transposase
I3M_RS00500	COG1560	Kdo2-lipid A biosynthetic process
I3M_RS00505	COG2194	sulfuric ester hydrolase activity
I3M_RS00510	COG0297	glycogen (starch) synthase activity
I3M_RS00515	COG0726	polysaccharide deacetylase
I3M_RS00540	COG0527	aspartate kinase activity
I3M_RS00540	COG0460	homoserine dehydrogenase
I3M_RS00550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3M_RS00565	COG1115	amino acid carrier protein
I3M_RS00575	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3M_RS00580	COG1584	GPR1 FUN34 yaaH family protein
I3M_RS00585	COG4735	regulation of single-species biofilm formation
I3M_RS00615	COG0583	DNA-binding transcription factor activity
I3M_RS00645	COG0196	riboflavin kinase activity
I3M_RS00660	COG1047	Peptidyl-prolyl cis-trans
I3M_RS00685	COG0505	Belongs to the CarA family
I3M_RS00690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3M_RS00745	COG0644	oxidoreductase
I3M_RS00750	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3M_RS00755	COG2271	Major facilitator Superfamily
I3M_RS00770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I3M_RS00810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3M_RS00815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3M_RS00820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I3M_RS00825	COG0564	pseudouridine synthase activity
I3M_RS00835	COG0417	DNA replication proofreading
I3M_RS00840	COG0235	Class ii aldolase
I3M_RS00860	COG4977	sequence-specific DNA binding
I3M_RS00865	COG0586	Pfam SNARE associated Golgi protein
I3M_RS00875	COG1178	ABC-type Fe3 transport system permease component
I3M_RS00880	COG4143	(ABC) transporter
I3M_RS00895	COG2814	Major facilitator Superfamily
I3M_RS00910	COG0473	3-isopropylmalate dehydrogenase activity
I3M_RS00925	COG0583	DNA-binding transcription factor activity
I3M_RS00930	COG0028	Belongs to the TPP enzyme family
I3M_RS00935	COG0440	acetolactate synthase activity
I3M_RS00945	COG1609	Transcriptional regulator
I3M_RS00970	COG3116	cell division
I3M_RS00975	COG0768	penicillin binding
I3M_RS00980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3M_RS00985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3M_RS01000	COG0772	Belongs to the SEDS family
I3M_RS01015	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3M_RS01020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3M_RS01025	COG0849	cell division
I3M_RS01030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3M_RS01050	COG0494	nUDIX hydrolase
I3M_RS01060	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS01075	COG0237	dephospho-CoA kinase activity
I3M_RS01085	COG1459	type II secretion system
I3M_RS01090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3M_RS01095	COG4969	Belongs to the N-Me-Phe pilin family
I3M_RS01105	COG0157	Belongs to the NadC ModD family
I3M_RS01110	COG3023	N-Acetylmuramoyl-L-alanine amidase
I3M_RS01115	COG3725	Membrane protein required for beta-lactamase induction
I3M_RS01120	COG1113	amino acid transport
I3M_RS01125	COG2186	Transcriptional regulator
I3M_RS01135	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3M_RS01140	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3M_RS01145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3M_RS01150	COG3064	Membrane
I3M_RS01160	COG1049	propionate catabolic process, 2-methylcitrate cycle
I3M_RS01185	COG2132	Multicopper oxidase
I3M_RS01190	COG4993	Dehydrogenase
I3M_RS01195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3M_RS01200	COG0288	reversible hydration of carbon dioxide
I3M_RS01205	COG1131	(ABC) transporter
I3M_RS01210	COG0842	Transport permease protein
I3M_RS01215	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS01220	COG0726	polysaccharide deacetylase
I3M_RS01235	COG5464	transposase or invertase
I3M_RS01255	COG3539	Fimbrial protein
I3M_RS01260	COG3539	Fimbrial protein
I3M_RS01265	COG3539	Fimbrial protein
I3M_RS01270	COG3188	usher protein
I3M_RS01275	COG3121	Chaperone
I3M_RS01280	COG3539	Fimbrial protein
I3M_RS01285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I3M_RS01290	COG0617	tRNA 3'-terminal CCA addition
I3M_RS01300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3M_RS01310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I3M_RS01315	COG1643	Atp-dependent helicase
I3M_RS01325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3M_RS01330	COG4774	siderophore transport
I3M_RS01335	COG1120	ATPase activity
I3M_RS01340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3M_RS01345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3M_RS01365	COG2860	membrane
I3M_RS01370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3M_RS01390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3M_RS01395	COG3835	regulator
I3M_RS01405	COG1408	metallophosphoesterase
I3M_RS01420	COG0024	Methionine aminopeptidase
I3M_RS01455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3M_RS01460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3M_RS01465	COG0575	Belongs to the CDS family
I3M_RS01470	COG0750	zinc metalloprotease
I3M_RS01480	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I3M_RS01485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3M_RS01510	COG0587	DNA-directed DNA polymerase activity
I3M_RS01520	COG1982	Orn Lys Arg decarboxylase major
I3M_RS01525	COG0346	lactoylglutathione lyase activity
I3M_RS01535	COG4568	rho-dependent transcription termination
I3M_RS01545	COG4681	YaeQ
I3M_RS01550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3M_RS01555	COG3015	lipoprotein NlpE involved in copper resistance
I3M_RS01565	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS01580	COG1720	tRNA m6t6A37 methyltransferase activity
I3M_RS01590	COG1464	Belongs to the NlpA lipoprotein family
I3M_RS01595	COG2011	ABC-type metal ion transport system permease component
I3M_RS01600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3M_RS01605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3M_RS01640	COG0656	L-ascorbic acid biosynthetic process
I3M_RS01645	COG0583	DNA-binding transcription factor activity
I3M_RS01655	COG2226	methyltransferase
I3M_RS01660	COG1388	LysM domain
I3M_RS01660	COG0741	lytic transglycosylase activity
I3M_RS01670	COG2226	methyltransferase
I3M_RS01680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS01705	COG4104	PAAR repeat-containing protein
I3M_RS01710	COG3157	Type VI secretion system effector, Hcp
I3M_RS01785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3M_RS01795	COG1960	acyl-CoA dehydrogenase activity
I3M_RS01805	COG0121	glutamine amidotransferase
I3M_RS01810	COG3034	peptidoglycan biosynthetic process
I3M_RS01815	COG3041	Addiction module toxin RelE StbE family
I3M_RS01820	COG3077	Addiction module antitoxin, RelB DinJ family
I3M_RS01825	COG0791	NLP P60 protein
I3M_RS01855	COG1987	bacterial-type flagellum assembly
I3M_RS01880	COG1677	Flagellar hook-basal body complex protein FliE
I3M_RS01890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3M_RS01910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3M_RS01940	COG1815	bacterial-type flagellum-dependent cell motility
I3M_RS01945	COG1558	bacterial-type flagellum-dependent cell motility
I3M_RS01955	COG1749	Flagellar hook protein flgE
I3M_RS01960	COG4787	bacterial-type flagellum-dependent cell motility
I3M_RS01965	COG4786	Flagellar basal body rod
I3M_RS01990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3M_RS02005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3M_RS02015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I3M_RS02040	COG1191	sigma factor activity
I3M_RS02045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3M_RS02060	COG0454	-acetyltransferase
I3M_RS02070	COG1690	Belongs to the RtcB family
I3M_RS02075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3M_RS02080	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3M_RS02100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3M_RS02195	COG0583	DNA-binding transcription factor activity
I3M_RS02200	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3M_RS02205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3M_RS02210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3M_RS02215	COG2080	2 iron, 2 sulfur cluster binding
I3M_RS02225	COG3477	response to acidic pH
I3M_RS02235	COG0727	PFAM Uncharacterised protein family (UPF0153)
I3M_RS02240	COG3121	Chaperone
I3M_RS02250	COG3188	usher protein
I3M_RS02300	COG1388	LysM domain
I3M_RS02305	COG3708	Transcriptional regulator
I3M_RS02305	COG2207	Transcriptional regulator
I3M_RS02310	COG0656	L-ascorbic acid biosynthetic process
I3M_RS02315	COG3059	membrane
I3M_RS02325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3M_RS02330	COG2207	Transcriptional regulator
I3M_RS02335	COG0247	lactate metabolic process
I3M_RS02340	COG1139	Iron-sulfur cluster binding protein
I3M_RS02345	COG1556	Lactate utilization protein
I3M_RS02385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3M_RS02395	COG2200	EAL domain
I3M_RS02395	COG2771	luxR family
I3M_RS02400	COG0583	DNA-binding transcription factor activity
I3M_RS02415	COG0666	response to abiotic stimulus
I3M_RS02425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3M_RS02430	COG1304	FMN binding
I3M_RS02435	COG0549	Belongs to the carbamate kinase family
I3M_RS02440	COG0402	S-adenosylhomocysteine deaminase activity
I3M_RS02450	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS02455	COG1129	ABC transporter
I3M_RS02460	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS02470	COG1064	alcohol dehydrogenase
I3M_RS02485	COG1280	lysine exporter protein (LysE YggA)
I3M_RS02495	COG3829	transcription factor binding
I3M_RS02500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3M_RS02505	COG0372	Belongs to the citrate synthase family
I3M_RS02510	COG2079	MmgE PrpD family protein
I3M_RS02515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3M_RS02520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I3M_RS02525	COG0402	S-adenosylhomocysteine deaminase activity
I3M_RS02530	COG0583	DNA-binding transcription factor activity
I3M_RS02535	COG0288	reversible hydration of carbon dioxide
I3M_RS02545	COG2807	transmembrane transport
I3M_RS02550	COG2223	nitrite transmembrane transporter activity
I3M_RS02555	COG3250	beta-galactosidase activity
I3M_RS02565	COG1609	Transcriptional regulator
I3M_RS02570	COG1414	Transcriptional regulator
I3M_RS02605	COG2814	Major facilitator Superfamily
I3M_RS02610	COG3122	Protein conserved in bacteria
I3M_RS02640	COG1215	transferase activity, transferring glycosyl groups
I3M_RS02645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3M_RS02655	COG4521	taurine ABC transporter
I3M_RS02660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3M_RS02665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3M_RS02670	COG2175	clavaminate synthase activity
I3M_RS02675	COG0113	porphobilinogen synthase activity
I3M_RS02700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3M_RS02705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3M_RS02715	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I3M_RS02740	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3M_RS02755	COG1785	Belongs to the alkaline phosphatase family
I3M_RS02765	COG3706	GGDEF domain
I3M_RS02770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3M_RS02795	COG4126	flavin adenine dinucleotide binding
I3M_RS02820	COG1940	carbohydrate kinase activity
I3M_RS02825	COG2814	Major facilitator Superfamily
I3M_RS02830	COG0419	ATPase involved in DNA repair
I3M_RS02835	COG0420	3'-5' exonuclease activity
I3M_RS02840	COG0745	RESPONSE REGULATOR receiver
I3M_RS02845	COG5002	protein histidine kinase activity
I3M_RS02850	COG1114	Component of the transport system for branched-chain amino acids
I3M_RS02855	COG1113	amino acid transport
I3M_RS02860	COG0366	Alpha amylase catalytic
I3M_RS02880	COG1862	Preprotein translocase
I3M_RS02885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3M_RS02890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3M_RS02895	COG1403	HNH endonuclease
I3M_RS02900	COG3248	Nucleoside-binding outer membrane protein
I3M_RS02905	COG4238	major outer membrane lipoprotein
I3M_RS02915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3M_RS02915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3M_RS02930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I3M_RS02935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I3M_RS02940	COG0667	Aldo Keto reductase
I3M_RS02950	COG0142	geranyltranstransferase activity
I3M_RS02965	COG0693	protein deglycase activity
I3M_RS02970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3M_RS02980	COG2814	Major facilitator Superfamily
I3M_RS03005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I3M_RS03010	COG1845	cytochrome c oxidase, subunit III
I3M_RS03015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3M_RS03020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3M_RS03025	COG2223	nitrite transmembrane transporter activity
I3M_RS03030	COG3056	Lipoprotein
I3M_RS03035	COG0271	Belongs to the BolA IbaG family
I3M_RS03060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3M_RS03065	COG0776	regulation of translation
I3M_RS03070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3M_RS03075	COG1555	photosystem II stabilization
I3M_RS03080	COG0824	Thioesterase
I3M_RS03090	COG4533	DNA binding
I3M_RS03100	COG1522	sequence-specific DNA binding
I3M_RS03105	COG1132	(ABC) transporter
I3M_RS03110	COG1132	(ABC) transporter
I3M_RS03115	COG0347	Belongs to the P(II) protein family
I3M_RS03120	COG0004	ammonium transporteR
I3M_RS03125	COG1946	Acyl-CoA thioesterase
I3M_RS03130	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I3M_RS03135	COG3695	enzyme binding
I3M_RS03145	COG5507	3-demethylubiquinone-9 3-methyltransferase
I3M_RS03150	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I3M_RS03160	COG0110	maltose O-acetyltransferase activity
I3M_RS03175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3M_RS03180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS03185	COG1309	transcriptional regulator
I3M_RS03195	COG1196	nuclear chromosome segregation
I3M_RS03195	COG3264	Mechanosensitive ion channel
I3M_RS03200	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS03215	COG3923	Primosomal replication protein n
I3M_RS03220	COG2832	Protein of unknown function (DUF454)
I3M_RS03235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3M_RS03275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS03280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3M_RS03280	COG4651	solute:proton antiporter activity
I3M_RS03285	COG2223	nitrite transmembrane transporter activity
I3M_RS03295	COG0737	Belongs to the 5'-nucleotidase family
I3M_RS03300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3M_RS03310	COG3735	TraB family
I3M_RS03320	COG3093	addiction module antidote protein HigA
I3M_RS03325	COG2217	Heavy metal translocating P-type atpase
I3M_RS03335	COG0531	amino acid
I3M_RS03340	COG0789	Transcriptional regulator
I3M_RS03345	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3M_RS03350	COG0330	HflC and HflK could
I3M_RS03355	COG4619	ABC transporter
I3M_RS03360	COG0390	transport system, permease component
I3M_RS03365	COG3118	belongs to the thioredoxin family
I3M_RS03370	COG0300	oxidoreductase activity
I3M_RS03375	COG2755	lipolytic protein G-D-S-L family
I3M_RS03380	COG4181	ATPase activity
I3M_RS03385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I3M_RS03410	COG0583	DNA-binding transcription factor activity
I3M_RS03420	COG1414	Transcriptional regulator
I3M_RS03425	COG3960	tartronate-semialdehyde synthase activity
I3M_RS03430	COG3622	Belongs to the hyi family
I3M_RS03435	COG2084	Dehydrogenase
I3M_RS03440	COG1953	Uracil, thiamine, allantoin
I3M_RS03455	COG1929	Belongs to the glycerate kinase type-1 family
I3M_RS03460	COG3257	ureidoglycine aminohydrolase activity
I3M_RS03465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3M_RS03470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I3M_RS03475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3M_RS03480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3M_RS03490	COG0549	Belongs to the carbamate kinase family
I3M_RS03495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3M_RS03500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3M_RS03515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3M_RS03525	COG1988	membrane-bound metal-dependent
I3M_RS03530	COG2501	S4 domain
I3M_RS03540	COG3539	Fimbrial protein
I3M_RS03545	COG3121	Chaperone
I3M_RS03550	COG3188	usher protein
I3M_RS03555	COG3539	Fimbrial protein
I3M_RS03560	COG3539	Fimbrial protein
I3M_RS03565	COG2197	response regulator
I3M_RS03575	COG0582	viral genome integration into host DNA
I3M_RS03740	COG3772	lysozyme
I3M_RS03770	COG4220	transposase activity
I3M_RS03795	COG4372	Transposase
I3M_RS03800	COG3436	PFAM IS66 Orf2 family protein
I3M_RS03860	COG1196	nuclear chromosome segregation
I3M_RS03895	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS03900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3M_RS03910	COG0500	methyltransferase
I3M_RS03925	COG4571	Outer membrane protease
I3M_RS03940	COG2207	Transcriptional regulator
I3M_RS03955	COG4783	chaperone-mediated protein folding
I3M_RS03960	COG1215	transferase activity, transferring glycosyl groups
I3M_RS03965	COG5433	transposase activity
I3M_RS03970	COG3209	COG3209 Rhs family protein
I3M_RS03970	COG4104	PAAR repeat-containing protein
I3M_RS03985	COG4104	PAAR repeat-containing protein
I3M_RS03985	COG3209	COG3209 Rhs family protein
I3M_RS03995	COG3501	Rhs element vgr protein
I3M_RS04000	COG5002	protein histidine kinase activity
I3M_RS04005	COG0745	RESPONSE REGULATOR receiver
I3M_RS04015	COG1538	Outer membrane efflux protein
I3M_RS04020	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS04025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS04030	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3M_RS04035	COG1113	amino acid transport
I3M_RS04040	COG0668	transmembrane transport
I3M_RS04045	COG0778	Nitroreductase
I3M_RS04050	COG2315	Protein conserved in bacteria
I3M_RS04085	COG2977	Belongs to the P-Pant transferase superfamily
I3M_RS04090	COG4771	TonB-dependent receptor
I3M_RS04100	COG2382	esterase
I3M_RS04105	COG3251	PFAM MbtH domain protein
I3M_RS04110	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3M_RS04110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3M_RS04115	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3M_RS04120	COG1120	ATPase activity
I3M_RS04125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3M_RS04130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3M_RS04140	COG4592	Periplasmic binding protein
I3M_RS04150	COG1169	isochorismate synthase
I3M_RS04155	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3M_RS04160	COG1535	isochorismatase
I3M_RS04160	COG3433	isochorismatase activity
I3M_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS04170	COG2050	protein possibly involved in aromatic compounds catabolism
I3M_RS04175	COG1966	Carbon starvation protein
I3M_RS04180	COG2879	small protein
I3M_RS04185	COG0371	Dehydrogenase
I3M_RS04190	COG0436	Aminotransferase
I3M_RS04195	COG1475	DNA binding
I3M_RS04200	COG3969	phosphoadenosine phosphosulfate
I3M_RS04205	COG0583	DNA-binding transcription factor activity
I3M_RS04210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3M_RS04215	COG0450	alkyl hydroperoxide reductase
I3M_RS04220	COG3634	alkyl hydroperoxide reductase activity
I3M_RS04225	COG0589	response to stress
I3M_RS04230	COG1063	alcohol dehydrogenase
I3M_RS04240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3M_RS04250	COG3719	Belongs to the RNase T2 family
I3M_RS04255	COG0471	metal ion transport
I3M_RS04270	COG3051	citrate lyase alpha subunit
I3M_RS04275	COG2301	Belongs to the HpcH HpaI aldolase family
I3M_RS04285	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I3M_RS04290	COG3290	protein histidine kinase activity
I3M_RS04295	COG4565	transcriptional regulatory protein
I3M_RS04300	COG3069	C4-dicarboxylate transmembrane transporter activity
I3M_RS04325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3M_RS04330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3M_RS04345	COG0583	DNA-binding transcription factor activity
I3M_RS04365	COG1686	Belongs to the peptidase S11 family
I3M_RS04370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3M_RS04375	COG0772	Belongs to the SEDS family
I3M_RS04380	COG0768	penicillin binding
I3M_RS04390	COG0799	negative regulation of ribosome biogenesis
I3M_RS04395	COG0406	alpha-ribazole phosphatase activity
I3M_RS04405	COG1466	dna polymerase III delta subunit
I3M_RS04420	COG2888	peptidyl-tyrosine sulfation
I3M_RS04425	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3M_RS04435	COG2214	Heat shock protein DnaJ domain protein
I3M_RS04440	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3M_RS04450	COG2214	Heat shock protein DnaJ domain protein
I3M_RS04455	COG0443	Heat shock 70 kDa protein
I3M_RS04465	COG1126	abc transporter atp-binding protein
I3M_RS04470	COG0765	amino acid transport
I3M_RS04475	COG0765	amino acid transport
I3M_RS04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS04495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3M_RS04500	COG4535	Mg2 and Co2 transporter CorC
I3M_RS04510	COG1702	phosphate starvation-inducible protein PhoH
I3M_RS04520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3M_RS04565	COG0367	asparagine synthase
I3M_RS04575	COG0647	UMP catabolic process
I3M_RS04580	COG1846	Transcriptional regulator
I3M_RS04580	COG1940	carbohydrate kinase activity
I3M_RS04585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3M_RS04595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS04595	COG1263	PTS System
I3M_RS04595	COG2190	(PTS) system
I3M_RS04620	COG0735	belongs to the Fur family
I3M_RS04630	COG0716	FMN binding
I3M_RS04640	COG0596	Alpha beta hydrolase
I3M_RS04645	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I3M_RS04650	COG0033	Phosphoglucomutase
I3M_RS04655	COG0531	amino acid
I3M_RS04660	COG1982	Orn Lys Arg decarboxylase major
I3M_RS04675	COG0745	RESPONSE REGULATOR receiver
I3M_RS04680	COG2205	protein histidine kinase activity
I3M_RS04710	COG3209	COG3209 Rhs family protein
I3M_RS04735	COG3272	Protein of unknown function (DUF1722)
I3M_RS04740	COG0415	Belongs to the DNA photolyase family
I3M_RS04750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3M_RS04755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3M_RS04760	COG1984	allophanate hydrolase subunit 2
I3M_RS04775	COG3180	Ammonia monooxygenase
I3M_RS04780	COG3539	Fimbrial protein
I3M_RS04785	COG3121	Chaperone
I3M_RS04790	COG3188	usher protein
I3M_RS04795	COG3539	Fimbrial protein
I3M_RS04800	COG0372	Belongs to the citrate synthase family
I3M_RS04815	COG2009	succinate dehydrogenase
I3M_RS04820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I3M_RS04825	COG1053	succinate dehydrogenase
I3M_RS04830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3M_RS04835	COG0567	Dehydrogenase, E1 component
I3M_RS04840	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3M_RS04850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3M_RS04855	COG2188	Transcriptional regulator
I3M_RS04860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS04860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS04860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS04865	COG0383	alpha-mannosidase activity
I3M_RS04875	COG1271	oxidase subunit
I3M_RS04880	COG1294	oxidase, subunit
I3M_RS04885	COG4890	Cyd operon protein YbgT
I3M_RS04890	COG3790	cyd operon protein YbgE
I3M_RS04895	COG0824	Thioesterase
I3M_RS04900	COG0811	peptide transport
I3M_RS04905	COG0848	biopolymer transport protein
I3M_RS04910	COG3064	Membrane
I3M_RS04920	COG2885	chlorophyll binding
I3M_RS04925	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I3M_RS04975	COG3201	nicotinamide mononucleotide transporter
I3M_RS04980	COG1230	cation diffusion facilitator family transporter
I3M_RS04995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3M_RS05005	COG2017	converts alpha-aldose to the beta-anomer
I3M_RS05015	COG1085	galactose-1-phosphate uridylyltransferase
I3M_RS05020	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3M_RS05025	COG1119	ATPase activity
I3M_RS05030	COG2005	Transcriptional regulator
I3M_RS05030	COG3585	molybdate ion transport
I3M_RS05045	COG0725	ABC transporter, periplasmic molybdate-binding protein
I3M_RS05050	COG4149	molybdate abc transporter
I3M_RS05060	COG0561	phosphatase activity
I3M_RS05070	COG0583	DNA-binding transcription factor activity
I3M_RS05075	COG2828	Protein conserved in bacteria
I3M_RS05080	COG0471	metal ion transport
I3M_RS05085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3M_RS05090	COG4677	pectinesterase activity
I3M_RS05095	COG0582	viral genome integration into host DNA
I3M_RS05315	COG3772	lysozyme
I3M_RS05340	COG4220	transposase activity
I3M_RS05375	COG3436	PFAM IS66 Orf2 family protein
I3M_RS05380	COG4372	Transposase
I3M_RS05440	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS05475	COG4372	Transposase
I3M_RS05480	COG3436	PFAM IS66 Orf2 family protein
I3M_RS05515	COG1881	PFAM PEBP family protein
I3M_RS05520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3M_RS05535	COG2226	methyltransferase
I3M_RS05540	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3M_RS05550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3M_RS05560	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3M_RS05570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I3M_RS05575	COG0314	molybdopterin synthase activity
I3M_RS05580	COG0670	Belongs to the BI1 family
I3M_RS05585	COG0670	Belongs to the BI1 family
I3M_RS05590	COG0392	lysyltransferase activity
I3M_RS05595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3M_RS05600	COG3568	Endonuclease Exonuclease Phosphatase
I3M_RS05610	COG0842	Transport permease protein
I3M_RS05615	COG0842	Transport permease protein
I3M_RS05620	COG1131	(ABC) transporter
I3M_RS05630	COG1309	transcriptional regulator
I3M_RS05635	COG0513	Belongs to the DEAD box helicase family
I3M_RS05640	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I3M_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3M_RS05650	COG1199	ATP-dependent helicase activity
I3M_RS05660	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I3M_RS05665	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS05680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3M_RS05690	COG4774	siderophore transport
I3M_RS05705	COG0668	transmembrane transport
I3M_RS05710	COG1126	abc transporter atp-binding protein
I3M_RS05715	COG0765	amino acid transport
I3M_RS05720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS05740	COG5006	permease, DMT superfamily
I3M_RS05745	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I3M_RS05750	COG2194	sulfuric ester hydrolase activity
I3M_RS05760	COG1321	iron dependent repressor
I3M_RS05765	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3M_RS05770	COG1376	ErfK ybiS ycfS ynhG family protein
I3M_RS05775	COG0488	(ABC) transporter
I3M_RS05785	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS05795	COG0561	phosphatase activity
I3M_RS05800	COG1882	Formate acetyltransferase
I3M_RS05805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3M_RS05810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3M_RS05815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3M_RS05820	COG0303	'Molybdopterin
I3M_RS05825	COG1446	asparaginase
I3M_RS05850	COG2200	EAL domain
I3M_RS05855	COG2199	diguanylate cyclase activity
I3M_RS05870	COG2133	pyrroloquinoline quinone binding
I3M_RS05875	COG0625	glutathione transferase activity
I3M_RS05880	COG1686	Belongs to the peptidase S11 family
I3M_RS05885	COG1349	DNA-binding transcription factor activity
I3M_RS05890	COG0671	phosphoesterase, PA-phosphatase related
I3M_RS05895	COG2814	Major facilitator Superfamily
I3M_RS05905	COG0561	phosphatase activity
I3M_RS05910	COG0738	Major facilitator superfamily
I3M_RS05915	COG3226	Transcriptional regulator
I3M_RS05930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3M_RS05940	COG0778	Nitroreductase
I3M_RS05960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3M_RS05965	COG3842	ATPase activity
I3M_RS05970	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3M_RS05975	COG1177	transmembrane transport
I3M_RS05990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS05995	COG4160	amino acid transport
I3M_RS06000	COG4215	(ABC) transporter
I3M_RS06005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS06010	COG1126	abc transporter atp-binding protein
I3M_RS06025	COG3023	N-Acetylmuramoyl-L-alanine amidase
I3M_RS06030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3M_RS06035	COG0702	epimerase
I3M_RS06040	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I3M_RS06045	COG0028	Belongs to the TPP enzyme family
I3M_RS06050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3M_RS06060	COG2431	L-lysine efflux transmembrane transporter activity
I3M_RS06075	COG3593	DNA synthesis involved in DNA repair
I3M_RS06080	COG2990	Protein conserved in bacteria
I3M_RS06085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS06090	COG1136	(ABC) transporter
I3M_RS06090	COG0577	efflux transmembrane transporter activity
I3M_RS06095	COG1278	Cold shock
I3M_RS06105	COG0542	response to heat
I3M_RS06125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3M_RS06130	COG4988	ABC transporter
I3M_RS06135	COG0492	ferredoxin-NADP+ reductase activity
I3M_RS06145	COG1522	sequence-specific DNA binding
I3M_RS06160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3M_RS06170	COG0243	molybdopterin cofactor binding
I3M_RS06175	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS06180	COG3302	dmso reductase anchor subunit
I3M_RS06185	COG1335	isochorismatase
I3M_RS06195	COG0531	amino acid
I3M_RS06200	COG0583	DNA-binding transcription factor activity
I3M_RS06205	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3M_RS06210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3M_RS06215	COG1882	Formate acetyltransferase
I3M_RS06220	COG2116	formate transmembrane transporter activity
I3M_RS06225	COG1944	ATP diphosphatase activity
I3M_RS06230	COG2323	membrane
I3M_RS06245	COG0501	Belongs to the peptidase M48B family
I3M_RS06255	COG0539	negative regulation of cytoplasmic translation
I3M_RS06265	COG0658	competence protein
I3M_RS06265	COG2333	competence protein COMEC
I3M_RS06270	COG1132	(ABC) transporter
I3M_RS06280	COG3214	Protein conserved in bacteria
I3M_RS06295	COG3173	Aminoglycoside phosphotransferase
I3M_RS06300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3M_RS06305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3M_RS06315	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I3M_RS06325	COG2989	Protein conserved in bacteria
I3M_RS06335	COG3108	Peptidase M15
I3M_RS06340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3M_RS06345	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS06355	COG1448	Aminotransferase
I3M_RS06375	COG0308	aminopeptidase N
I3M_RS06385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3M_RS06395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3M_RS06400	COG0431	NADPH-dependent FMN reductase
I3M_RS06410	COG3539	Fimbrial protein
I3M_RS06415	COG3121	Chaperone
I3M_RS06420	COG3188	usher protein
I3M_RS06425	COG3539	Fimbrial protein
I3M_RS06430	COG3539	Fimbrial protein
I3M_RS06435	COG3539	Fimbrial protein
I3M_RS06440	COG3121	Chaperone
I3M_RS06455	COG0633	Ferredoxin
I3M_RS06455	COG3217	Mosc domain protein beta barrel domain protein
I3M_RS06465	COG0488	(ABC) transporter
I3M_RS06470	COG2995	paraquat-inducible protein a
I3M_RS06475	COG3008	intermembrane lipid transfer
I3M_RS06475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3M_RS06480	COG3009	Protein conserved in bacteria
I3M_RS06485	COG3130	regulation of translation
I3M_RS06495	COG1067	ATP-dependent peptidase activity
I3M_RS06505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I3M_RS06505	COG2885	chlorophyll binding
I3M_RS06520	COG3070	regulator of competence-specific genes
I3M_RS06525	COG1289	transmembrane transporter activity
I3M_RS06530	COG3304	Inner membrane component domain
I3M_RS06535	COG0210	DNA helicase
I3M_RS06550	COG1832	CoA-binding protein
I3M_RS06565	COG1254	Belongs to the acylphosphatase family
I3M_RS06570	COG2920	part of a sulfur-relay system
I3M_RS06575	COG0670	Belongs to the BI1 family
I3M_RS06590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS06660	COG1484	DNA-dependent DNA replication
I3M_RS06665	COG1846	Transcriptional regulator
I3M_RS06700	COG1403	HNH endonuclease
I3M_RS06705	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS06725	COG2207	Transcriptional regulator
I3M_RS06780	COG3772	lysozyme
I3M_RS06810	COG4220	transposase activity
I3M_RS06830	COG1030	water channel activity
I3M_RS06955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS07025	COG1846	Transcriptional regulator
I3M_RS07095	COG1403	HNH endonuclease
I3M_RS07100	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS07115	COG2207	Transcriptional regulator
I3M_RS07170	COG3772	lysozyme
I3M_RS07280	COG1185	polyribonucleotide nucleotidyltransferase activity
I3M_RS07345	COG3729	General stress protein
I3M_RS07350	COG2233	PERMEase
I3M_RS07385	COG1309	transcriptional regulator
I3M_RS07390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3M_RS07390	COG0506	proline dehydrogenase activity
I3M_RS07390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3M_RS07405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3M_RS07425	COG2822	iron ion transport
I3M_RS07435	COG1702	phosphate starvation-inducible protein PhoH
I3M_RS07455	COG0582	viral genome integration into host DNA
I3M_RS07485	COG4983	Phage plasmid primase, P4 family domain protein
I3M_RS07510	COG4372	Transposase
I3M_RS07515	COG3436	PFAM IS66 Orf2 family protein
I3M_RS07560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3M_RS07565	COG2194	sulfuric ester hydrolase activity
I3M_RS07580	COG0829	nickel cation binding
I3M_RS07625	COG0254	rRNA binding
I3M_RS07670	COG3436	PFAM IS66 Orf2 family protein
I3M_RS07675	COG4372	Transposase
I3M_RS07715	COG1358	cellular component organization or biogenesis
I3M_RS07780	COG4771	TonB-dependent receptor
I3M_RS07880	COG2831	hemolysin activation secretion protein
I3M_RS07890	COG3969	phosphoadenosine phosphosulfate
I3M_RS07895	COG3969	phosphoadenosine phosphosulfate
I3M_RS07900	COG1475	DNA binding
I3M_RS07990	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS08030	COG2003	Belongs to the UPF0758 family
I3M_RS08080	COG3381	protein complex oligomerization
I3M_RS08090	COG1462	curli production assembly transport component CsgG
I3M_RS08105	COG2197	response regulator
I3M_RS08140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3M_RS08145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3M_RS08170	COG2943	transferase activity, transferring hexosyl groups
I3M_RS08175	COG5645	(Lipo)protein
I3M_RS08190	COG1560	Kdo2-lipid A biosynthetic process
I3M_RS08200	COG2353	YceI-like domain
I3M_RS08205	COG3038	cytochrome b561
I3M_RS08245	COG2999	glutathione oxidoreductase activity
I3M_RS08255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3M_RS08265	COG0673	inositol 2-dehydrogenase activity
I3M_RS08270	COG0728	peptidoglycan biosynthetic process
I3M_RS08275	COG3418	PFAM FlgN family protein
I3M_RS08280	COG2747	anti-sigma28 factor FlgM
I3M_RS08285	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I3M_RS08290	COG1815	bacterial-type flagellum-dependent cell motility
I3M_RS08295	COG1558	bacterial-type flagellum-dependent cell motility
I3M_RS08300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I3M_RS08305	COG1749	Flagellar hook protein flgE
I3M_RS08310	COG4787	bacterial-type flagellum-dependent cell motility
I3M_RS08315	COG4786	Flagellar basal body rod
I3M_RS08330	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3M_RS08330	COG3951	Flagellar rod assembly protein muramidase FlgJ
I3M_RS08335	COG1256	bacterial-type flagellum assembly
I3M_RS08340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3M_RS08345	COG1530	ribonuclease E activity
I3M_RS08355	COG0564	pseudouridine synthase activity
I3M_RS08360	COG0424	maF-like protein
I3M_RS08365	COG1399	metal-binding, possibly nucleic acid-binding protein
I3M_RS08385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I3M_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS08400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3M_RS08405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3M_RS08410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3M_RS08420	COG0470	DNA polymerase III
I3M_RS08425	COG0084	hydrolase, TatD family'
I3M_RS08430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS08430	COG1263	PTS System
I3M_RS08435	COG4773	Receptor
I3M_RS08440	COG0537	adenosine 5'-monophosphoramidase activity
I3M_RS08445	COG5633	Lipoprotein
I3M_RS08450	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I3M_RS08470	COG1252	NADH dehydrogenase
I3M_RS08480	COG3134	Outer membrane lipoprotein
I3M_RS08485	COG1309	transcriptional regulator
I3M_RS08495	COG1376	ErfK ybiS ycfS ynhG family protein
I3M_RS08495	COG1388	LysM domain
I3M_RS08500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I3M_RS08505	COG4763	Acyl-transferase
I3M_RS08510	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3M_RS08515	COG1136	(ABC) transporter
I3M_RS08520	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3M_RS08530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3M_RS08535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I3M_RS08545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3M_RS08550	COG1177	transmembrane transport
I3M_RS08565	COG0582	viral genome integration into host DNA
I3M_RS08575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS08630	COG1846	Transcriptional regulator
I3M_RS08685	COG1403	HNH endonuclease
I3M_RS08690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS08760	COG3772	lysozyme
I3M_RS08895	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS08910	COG3436	PFAM IS66 Orf2 family protein
I3M_RS08915	COG4372	Transposase
I3M_RS08950	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I3M_RS08955	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I3M_RS08960	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I3M_RS08965	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3M_RS08970	COG1999	signal sequence binding
I3M_RS08975	COG1773	rubredoxin
I3M_RS08985	COG1294	oxidase, subunit
I3M_RS09000	COG0489	protein tyrosine kinase activity
I3M_RS09000	COG3206	protein involved in exopolysaccharide biosynthesis
I3M_RS09005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3M_RS09010	COG1596	polysaccharide export
I3M_RS09015	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3M_RS09035	COG1278	Cold shock
I3M_RS09040	COG1278	Cold shock
I3M_RS09060	COG0348	domain, Protein
I3M_RS09065	COG2205	protein histidine kinase activity
I3M_RS09065	COG2198	Histidine kinase
I3M_RS09065	COG0784	Response regulator, receiver
I3M_RS09070	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS09075	COG0745	RESPONSE REGULATOR receiver
I3M_RS09080	COG3005	denitrification pathway
I3M_RS09085	COG0243	molybdopterin cofactor binding
I3M_RS09125	COG0582	viral genome integration into host DNA
I3M_RS09245	COG4680	protein conserved in bacteria
I3M_RS09400	COG3772	lysozyme
I3M_RS09520	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS09585	COG2850	peptidyl-arginine hydroxylation
I3M_RS09670	COG4220	transposase activity
I3M_RS09685	COG2205	protein histidine kinase activity
I3M_RS09695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3M_RS09715	COG1187	pseudouridine synthase activity
I3M_RS09720	COG0538	isocitrate dehydrogenase activity
I3M_RS09730	COG5562	phage envelope protein
I3M_RS09735	COG0789	Transcriptional regulator
I3M_RS09740	COG2200	EAL domain
I3M_RS09765	COG2200	EAL domain
I3M_RS09825	COG2894	cell division
I3M_RS09860	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3M_RS09875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3M_RS09880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3M_RS09900	COG2719	SpoVR family
I3M_RS09910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3M_RS09925	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3M_RS09940	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I3M_RS09965	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I3M_RS09965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS09965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3M_RS09970	COG1461	Dihydroxyacetone kinase
I3M_RS09975	COG2376	Dihydroxyacetone kinase
I3M_RS09980	COG3284	Transcriptional regulator
I3M_RS09985	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS10000	COG0012	GTP binding
I3M_RS10015	COG0659	secondary active sulfate transmembrane transporter activity
I3M_RS10025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3M_RS10055	COG2890	protein-(glutamine-N5) methyltransferase activity
I3M_RS10060	COG3094	Invasion gene expression up-regulator, SirB
I3M_RS10065	COG2912	Transglutaminase-like superfamily
I3M_RS10095	COG0387	Pfam Sodium calcium exchanger
I3M_RS10100	COG4572	Cation transport regulator
I3M_RS10105	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I3M_RS10110	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I3M_RS10115	COG4932	domain protein
I3M_RS10120	COG2197	response regulator
I3M_RS10125	COG3850	Histidine kinase
I3M_RS10135	COG2223	nitrite transmembrane transporter activity
I3M_RS10140	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3M_RS10145	COG1140	nitrate reductase beta subunit
I3M_RS10150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3M_RS10155	COG2181	nitrate reductase activity
I3M_RS10175	COG0788	formyltetrahydrofolate deformylase activity
I3M_RS10185	COG1752	Esterase of the alpha-beta hydrolase superfamily
I3M_RS10190	COG0745	RESPONSE REGULATOR receiver
I3M_RS10195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3M_RS10205	COG1435	thymidine kinase activity
I3M_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS10215	COG1454	alcohol dehydrogenase
I3M_RS10220	COG2095	MarC family integral membrane protein
I3M_RS10230	COG4166	transmembrane transport
I3M_RS10235	COG0601	transmembrane transport
I3M_RS10240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3M_RS10245	COG0444	Belongs to the ABC transporter superfamily
I3M_RS10250	COG4608	Belongs to the ABC transporter superfamily
I3M_RS10270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3M_RS10275	COG2350	Protein conserved in bacteria
I3M_RS10285	COG1607	acyl-coa hydrolase
I3M_RS10305	COG3047	cAMP biosynthetic process
I3M_RS10310	COG0582	viral genome integration into host DNA
I3M_RS10360	COG1396	sequence-specific DNA binding
I3M_RS10415	COG1403	HNH endonuclease
I3M_RS10420	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS10475	COG3772	lysozyme
I3M_RS10580	COG3685	Protein conserved in bacteria
I3M_RS10585	COG3685	Protein conserved in bacteria
I3M_RS10590	COG3729	General stress protein
I3M_RS10605	COG0135	phosphoribosylanthranilate isomerase activity
I3M_RS10605	COG0134	indole-3-glycerol-phosphate synthase activity
I3M_RS10610	COG0512	Glutamine amidotransferase of anthranilate synthase
I3M_RS10610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3M_RS10615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3M_RS10625	COG0613	PHP domain protein
I3M_RS10630	COG0009	L-threonylcarbamoyladenylate synthase
I3M_RS10635	COG1187	pseudouridine synthase activity
I3M_RS10640	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I3M_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS10650	COG0616	signal peptide processing
I3M_RS10665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3M_RS10675	COG0583	DNA-binding transcription factor activity
I3M_RS10695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3M_RS10705	COG0671	phosphoesterase, PA-phosphatase related
I3M_RS10710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I3M_RS10715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I3M_RS10725	COG0023	Translation Initiation Factor
I3M_RS10735	COG1349	DNA-binding transcription factor activity
I3M_RS10745	COG5001	Diguanylate cyclase
I3M_RS10760	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3M_RS10760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3M_RS10765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3M_RS10770	COG2852	Protein conserved in bacteria
I3M_RS10775	COG4172	Belongs to the ABC transporter superfamily
I3M_RS10780	COG4172	Belongs to the ABC transporter superfamily
I3M_RS10785	COG4171	peptide transport system, permease
I3M_RS10790	COG4168	peptide transport system, permease
I3M_RS10795	COG4166	transmembrane transport
I3M_RS10810	COG0531	amino acid
I3M_RS10815	COG0174	glutamine synthetase
I3M_RS10820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3M_RS10825	COG1396	sequence-specific DNA binding
I3M_RS10825	COG1917	Cupin 2, conserved barrel domain protein
I3M_RS10835	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS10840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3M_RS10845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3M_RS10850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I3M_RS10855	COG1842	Phage shock protein A
I3M_RS10865	COG1983	PspC domain protein
I3M_RS10875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3M_RS10885	COG1653	transport
I3M_RS10890	COG1175	transmembrane transport
I3M_RS10895	COG0395	ABC-type sugar transport system, permease component
I3M_RS10900	COG1063	alcohol dehydrogenase
I3M_RS10905	COG1082	Xylose isomerase domain protein TIM barrel
I3M_RS10910	COG0673	inositol 2-dehydrogenase activity
I3M_RS10915	COG1554	hydrolase, family 65, central catalytic
I3M_RS10920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3M_RS10925	COG3842	ATPase activity
I3M_RS10935	COG1609	Transcriptional regulator
I3M_RS10940	COG3106	COG3106 Predicted ATPase
I3M_RS10950	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I3M_RS10955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I3M_RS10960	COG4948	Mandelate Racemase Muconate Lactonizing
I3M_RS10965	COG2866	Carboxypeptidase
I3M_RS10970	COG0702	epimerase
I3M_RS10975	COG1073	alpha beta
I3M_RS10980	COG1073	alpha beta
I3M_RS10985	COG0583	DNA-binding transcription factor activity
I3M_RS10990	COG4166	transmembrane transport
I3M_RS10995	COG0668	transmembrane transport
I3M_RS11000	COG3182	Iron-regulated membrane protein
I3M_RS11005	COG0589	response to stress
I3M_RS11010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3M_RS11015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3M_RS11020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3M_RS11030	COG1473	amidohydrolase
I3M_RS11035	COG1473	amidohydrolase
I3M_RS11040	COG0583	DNA-binding transcription factor activity
I3M_RS11045	COG2840	Smr protein MutS2
I3M_RS11050	COG3706	GGDEF domain
I3M_RS11065	COG0513	Belongs to the DEAD box helicase family
I3M_RS11075	COG0582	viral genome integration into host DNA
I3M_RS11095	COG3723	Recombinational DNA repair protein, rece pathway
I3M_RS11100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS11145	COG3756	Protein conserved in bacteria
I3M_RS11160	COG1484	DNA-dependent DNA replication
I3M_RS11165	COG1846	Transcriptional regulator
I3M_RS11235	COG1403	HNH endonuclease
I3M_RS11240	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS11245	COG0484	heat shock protein binding
I3M_RS11275	COG3772	lysozyme
I3M_RS11305	COG4220	transposase activity
I3M_RS11325	COG1030	water channel activity
I3M_RS11410	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS11440	COG0589	response to stress
I3M_RS11445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3M_RS11455	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3M_RS11455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3M_RS11455	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3M_RS11455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3M_RS11460	COG3042	response to heat
I3M_RS11465	COG3187	Heat shock protein
I3M_RS11470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3M_RS11475	COG2911	Protein conserved in bacteria
I3M_RS11485	COG3784	Protein of unknown function (DUF1318)
I3M_RS11490	COG2207	Transcriptional regulator
I3M_RS11495	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS11500	COG3733	amine oxidase
I3M_RS11505	COG2030	dehydratase
I3M_RS11505	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS11510	COG3396	Phenylacetate-CoA oxygenase
I3M_RS11515	COG3460	Phenylacetate-CoA oxygenase
I3M_RS11520	COG3396	Phenylacetate-CoA oxygenase
I3M_RS11525	COG2151	metal-sulfur cluster biosynthetic enzyme
I3M_RS11530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3M_RS11535	COG1024	Enoyl-CoA hydratase
I3M_RS11540	COG1024	Enoyl-CoA hydratase
I3M_RS11545	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3M_RS11550	COG2050	protein possibly involved in aromatic compounds catabolism
I3M_RS11555	COG0183	Belongs to the thiolase family
I3M_RS11560	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I3M_RS11565	COG3327	negative regulation of DNA-templated transcription, initiation
I3M_RS11570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3M_RS11575	COG0667	Aldo Keto reductase
I3M_RS11585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3M_RS11590	COG4589	Belongs to the CDS family
I3M_RS11595	COG2267	carboxylic ester hydrolase activity
I3M_RS11600	COG2453	phosphatase
I3M_RS11600	COG0671	phosphoesterase, PA-phosphatase related
I3M_RS11610	COG1643	Atp-dependent helicase
I3M_RS11615	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3M_RS11620	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS11625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3M_RS11630	COG3038	cytochrome b561
I3M_RS11645	COG0840	transmembrane signaling receptor activity
I3M_RS11650	COG0583	DNA-binding transcription factor activity
I3M_RS11655	COG5383	Protein conserved in bacteria
I3M_RS11675	COG2841	Protein conserved in bacteria
I3M_RS11680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3M_RS11685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3M_RS11690	COG1275	C4-dicarboxylate transporter malic acid transport protein
I3M_RS11695	COG0500	methyltransferase
I3M_RS11710	COG0675	Transposase, IS605 OrfB family
I3M_RS11715	COG3135	benzoate transporter
I3M_RS11720	COG1396	sequence-specific DNA binding
I3M_RS11725	COG0826	peptidase U32
I3M_RS11735	COG1724	mRNA binding
I3M_RS11740	COG1598	PFAM Uncharacterised protein family UPF0150
I3M_RS11750	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3M_RS11755	COG3842	ATPase activity
I3M_RS11760	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3M_RS11765	COG1177	transmembrane transport
I3M_RS11800	COG3238	Protein conserved in bacteria
I3M_RS11805	COG1247	-acetyltransferase
I3M_RS11815	COG2130	NADP-dependent
I3M_RS11820	COG1802	Transcriptional regulator
I3M_RS11825	COG4772	TonB-dependent receptor
I3M_RS11840	COG3391	amine dehydrogenase activity
I3M_RS11845	COG1113	amino acid transport
I3M_RS11850	COG0625	glutathione transferase activity
I3M_RS11895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3M_RS11900	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I3M_RS11905	COG0384	phenazine biosynthesis protein PhzF
I3M_RS11910	COG2181	nitrate reductase activity
I3M_RS11915	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3M_RS11920	COG1140	nitrate reductase beta subunit
I3M_RS11925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3M_RS11930	COG2223	nitrite transmembrane transporter activity
I3M_RS11935	COG4886	Leucine-rich repeat (LRR) protein
I3M_RS11940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3M_RS11945	COG0697	spore germination
I3M_RS11950	COG3383	formate dehydrogenase (NAD+) activity
I3M_RS11950	COG0243	molybdopterin cofactor binding
I3M_RS11955	COG3383	formate dehydrogenase (NAD+) activity
I3M_RS11955	COG0243	molybdopterin cofactor binding
I3M_RS11960	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS11965	COG2864	formate dehydrogenase
I3M_RS11970	COG3093	addiction module antidote protein HigA
I3M_RS11975	COG1064	alcohol dehydrogenase
I3M_RS12000	COG1764	response to oxidative stress
I3M_RS12005	COG4608	Belongs to the ABC transporter superfamily
I3M_RS12010	COG0444	Belongs to the ABC transporter superfamily
I3M_RS12015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3M_RS12020	COG0601	transmembrane transport
I3M_RS12025	COG0747	negative chemotaxis
I3M_RS12030	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I3M_RS12035	COG2202	Pas domain
I3M_RS12035	COG2200	EAL domain
I3M_RS12035	COG2199	diguanylate cyclase activity
I3M_RS12045	COG1649	PFAM Uncharacterised BCR, COG1649
I3M_RS12050	COG0531	amino acid
I3M_RS12055	COG0076	glutamate decarboxylase activity
I3M_RS12060	COG0612	Peptidase, M16
I3M_RS12065	COG4771	TonB-dependent receptor
I3M_RS12070	COG4178	(ABC) transporter
I3M_RS12075	COG0641	radical SAM
I3M_RS12080	COG3119	arylsulfatase activity
I3M_RS12085	COG2207	Transcriptional regulator
I3M_RS12095	COG0243	molybdopterin cofactor binding
I3M_RS12100	COG3539	Fimbrial protein
I3M_RS12105	COG3539	Fimbrial protein
I3M_RS12110	COG3539	Fimbrial protein
I3M_RS12115	COG3188	usher protein
I3M_RS12125	COG3539	Fimbrial protein
I3M_RS12145	COG3550	peptidyl-serine autophosphorylation
I3M_RS12150	COG1396	sequence-specific DNA binding
I3M_RS12160	COG2911	Protein conserved in bacteria
I3M_RS12160	COG3210	domain, Protein
I3M_RS12205	COG3781	membrane
I3M_RS12225	COG2199	diguanylate cyclase activity
I3M_RS12240	COG2066	Belongs to the glutaminase family
I3M_RS12245	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS12250	COG0583	DNA-binding transcription factor activity
I3M_RS12275	COG1846	Transcriptional regulator
I3M_RS12280	COG4977	sequence-specific DNA binding
I3M_RS12290	COG2723	6-phospho-beta-galactosidase activity
I3M_RS12300	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3M_RS12305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3M_RS12315	COG2188	Transcriptional regulator
I3M_RS12320	COG0697	spore germination
I3M_RS12325	COG2814	Major facilitator Superfamily
I3M_RS12350	COG3111	PFAM Bacterial OB fold (BOF) protein
I3M_RS12355	COG1546	Belongs to the CinA family
I3M_RS12365	COG0339	signal peptide processing
I3M_RS12375	COG4221	oxidoreductase activity
I3M_RS12380	COG1802	Transcriptional regulator
I3M_RS12395	COG0477	Major facilitator Superfamily
I3M_RS12410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3M_RS12415	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3M_RS12420	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS12495	COG0740	serine-type endopeptidase activity
I3M_RS12530	COG5562	phage envelope protein
I3M_RS12550	COG1278	Cold shock
I3M_RS12560	COG3772	lysozyme
I3M_RS12575	COG1278	Cold shock
I3M_RS12580	COG1278	Cold shock
I3M_RS12585	COG0484	heat shock protein binding
I3M_RS12590	COG1403	HNH endonuclease
I3M_RS12610	COG2026	Addiction module toxin, RelE StbE family
I3M_RS12615	COG3077	Addiction module antitoxin, RelB DinJ family
I3M_RS12630	COG2801	Transposase and inactivated derivatives
I3M_RS12640	COG1846	Transcriptional regulator
I3M_RS12655	COG1396	sequence-specific DNA binding
I3M_RS12680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS12690	COG4372	Transposase
I3M_RS12695	COG3436	PFAM IS66 Orf2 family protein
I3M_RS12750	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS12835	COG1030	water channel activity
I3M_RS12855	COG4220	transposase activity
I3M_RS12890	COG3772	lysozyme
I3M_RS12965	COG0484	heat shock protein binding
I3M_RS12970	COG1403	HNH endonuclease
I3M_RS13015	COG1846	Transcriptional regulator
I3M_RS13020	COG1484	DNA-dependent DNA replication
I3M_RS13025	COG1846	Transcriptional regulator
I3M_RS13040	COG1396	sequence-specific DNA binding
I3M_RS13075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS13085	COG0582	viral genome integration into host DNA
I3M_RS13095	COG1063	alcohol dehydrogenase
I3M_RS13100	COG4948	Mandelate Racemase Muconate Lactonizing
I3M_RS13120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3M_RS13140	COG0243	molybdopterin cofactor binding
I3M_RS13145	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS13150	COG3302	dmso reductase anchor subunit
I3M_RS13155	COG3381	protein complex oligomerization
I3M_RS13165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3M_RS13170	COG1940	carbohydrate kinase activity
I3M_RS13175	COG0583	DNA-binding transcription factor activity
I3M_RS13180	COG2814	Major facilitator Superfamily
I3M_RS13200	COG3591	Belongs to the peptidase S1B family
I3M_RS13230	COG1802	Transcriptional regulator
I3M_RS13230	COG4626	Terminase
I3M_RS13345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I3M_RS13350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I3M_RS13365	COG0531	amino acid
I3M_RS13375	COG3136	membrane protein required for alginate biosynthesis
I3M_RS13380	COG0745	RESPONSE REGULATOR receiver
I3M_RS13385	COG2205	protein histidine kinase activity
I3M_RS13395	COG0114	fumarate hydratase activity
I3M_RS13400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3M_RS13400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3M_RS13405	COG1482	cell wall glycoprotein biosynthetic process
I3M_RS13410	COG5339	Protein conserved in bacteria
I3M_RS13425	COG3250	beta-galactosidase activity
I3M_RS13430	COG1309	transcriptional regulator
I3M_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS13440	COG1609	Transcriptional regulator
I3M_RS13445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS13445	COG1263	PTS System
I3M_RS13450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3M_RS13460	COG0673	inositol 2-dehydrogenase activity
I3M_RS13505	COG4659	FMN binding
I3M_RS13515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I3M_RS13525	COG3104	oligopeptide transport
I3M_RS13530	COG0625	glutathione transferase activity
I3M_RS13535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I3M_RS13550	COG3895	Periplasmic Protein
I3M_RS13560	COG3133	Outer membrane lipoprotein
I3M_RS13575	COG1566	PFAM secretion protein HlyD family protein
I3M_RS13580	COG1289	transmembrane transporter activity
I3M_RS13585	COG2032	superoxide dismutase activity
I3M_RS13590	COG4989	oxidoreductase activity
I3M_RS13595	COG3313	Fe-S protein
I3M_RS13600	COG1309	transcriptional regulator
I3M_RS13605	COG1902	pentaerythritol trinitrate reductase activity
I3M_RS13610	COG0346	lactoylglutathione lyase activity
I3M_RS13620	COG1201	RNA secondary structure unwinding
I3M_RS13625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I3M_RS13630	COG0791	NLP P60 protein
I3M_RS13635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3M_RS13640	COG2814	Major facilitator Superfamily
I3M_RS13660	COG0583	DNA-binding transcription factor activity
I3M_RS13665	COG2814	Major facilitator Superfamily
I3M_RS13670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3M_RS13675	COG0307	riboflavin synthase, alpha
I3M_RS13685	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS13705	COG4529	Protein conserved in bacteria
I3M_RS13715	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I3M_RS13720	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS13730	COG2414	aldehyde ferredoxin oxidoreductase
I3M_RS13735	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS13745	COG0469	pyruvate kinase activity
I3M_RS13750	COG4238	major outer membrane lipoprotein
I3M_RS13755	COG1376	ErfK ybiS ycfS ynhG family protein
I3M_RS13770	COG0719	Fe-S assembly protein
I3M_RS13775	COG0396	ATPase activity
I3M_RS13780	COG0719	Fe-S assembly protein
I3M_RS13785	COG0316	Belongs to the HesB IscA family
I3M_RS13795	COG2050	protein possibly involved in aromatic compounds catabolism
I3M_RS13800	COG0247	lactate metabolic process
I3M_RS13800	COG0277	FAD linked oxidase domain protein
I3M_RS13810	COG0628	permease
I3M_RS13825	COG0738	Major facilitator superfamily
I3M_RS13830	COG2271	Major facilitator Superfamily
I3M_RS13850	COG1960	acyl-CoA dehydrogenase activity
I3M_RS13855	COG2207	Transcriptional regulator
I3M_RS13855	COG1917	Cupin 2, conserved barrel domain protein
I3M_RS13865	COG2086	electron transfer activity
I3M_RS13870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3M_RS13875	COG0644	oxidoreductase
I3M_RS13880	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3M_RS13885	COG0318	PFAM AMP-dependent synthetase and ligase
I3M_RS13890	COG0574	Belongs to the PEP-utilizing enzyme family
I3M_RS13890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3M_RS13905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3M_RS13910	COG4256	Hemin uptake protein
I3M_RS13920	COG2200	EAL domain
I3M_RS13925	COG0791	NLP P60 protein
I3M_RS13935	COG0386	Belongs to the glutathione peroxidase family
I3M_RS13955	COG4974	Belongs to the 'phage' integrase family
I3M_RS14025	COG4695	Portal protein
I3M_RS14110	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS14115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3M_RS14225	COG3137	Salt-induced outer membrane protein
I3M_RS14230	COG1105	Belongs to the carbohydrate kinase PfkB family
I3M_RS14240	COG3001	Fructosamine kinase
I3M_RS14250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3M_RS14255	COG1988	membrane-bound metal-dependent
I3M_RS14260	COG1823	symporter activity
I3M_RS14280	COG0753	catalase activity
I3M_RS14290	COG1486	melibiose metabolic process
I3M_RS14295	COG2169	Transcriptional regulator
I3M_RS14295	COG1917	Cupin 2, conserved barrel domain protein
I3M_RS14300	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3M_RS14305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3M_RS14310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3M_RS14320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3M_RS14330	COG0322	excinuclease ABC activity
I3M_RS14340	COG3678	ATP-independent chaperone mediated protein folding
I3M_RS14375	COG0708	Exodeoxyribonuclease III
I3M_RS14380	COG0398	Pfam SNARE associated Golgi protein
I3M_RS14390	COG0398	Pfam SNARE associated Golgi protein
I3M_RS14395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3M_RS14400	COG4134	Bacterial extracellular solute-binding protein
I3M_RS14405	COG4135	transport system, permease component
I3M_RS14410	COG4136	ATPase activity
I3M_RS14415	COG2897	thiosulfate sulfurtransferase activity
I3M_RS14420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3M_RS14425	COG0494	nUDIX hydrolase
I3M_RS14435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3M_RS14445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3M_RS14460	COG0778	Nitroreductase
I3M_RS14470	COG0616	signal peptide processing
I3M_RS14475	COG0252	asparaginase activity
I3M_RS14480	COG1335	isochorismatase
I3M_RS14485	COG3139	Protein of unknown function (DUF1315)
I3M_RS14495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3M_RS14500	COG0676	glucose-6-phosphate 1-epimerase activity
I3M_RS14505	COG0656	L-ascorbic acid biosynthetic process
I3M_RS14510	COG3713	MltA-interacting MipA family protein
I3M_RS14515	COG2766	serine protein kinase
I3M_RS14525	COG2199	diguanylate cyclase activity
I3M_RS14530	COG2199	diguanylate cyclase activity
I3M_RS14535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3M_RS14550	COG2207	Transcriptional regulator
I3M_RS14555	COG2807	transmembrane transport
I3M_RS14560	COG3189	MarR family transcriptional regulator
I3M_RS14565	COG3042	response to heat
I3M_RS14570	COG2203	Gaf domain
I3M_RS14570	COG2199	diguanylate cyclase activity
I3M_RS14585	COG2261	transglycosylase associated protein
I3M_RS14610	COG3615	Tellurite resistance protein tehB
I3M_RS14620	COG0583	DNA-binding transcription factor activity
I3M_RS14625	COG0473	3-isopropylmalate dehydrogenase activity
I3M_RS14630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3M_RS14635	COG4638	Rieske (2fe-2S)
I3M_RS14640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3M_RS14645	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3M_RS14650	COG0318	PFAM AMP-dependent synthetase and ligase
I3M_RS14655	COG3065	identical protein binding
I3M_RS14660	COG1214	PFAM Peptidase M22, glycoprotease
I3M_RS14665	COG1199	ATP-dependent helicase activity
I3M_RS14670	COG0251	oxidation-reduction process
I3M_RS14685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3M_RS14695	COG1760	l-serine dehydratase
I3M_RS14700	COG2200	EAL domain
I3M_RS14705	COG1253	flavin adenine dinucleotide binding
I3M_RS14720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS14720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS14725	COG3715	PTS system
I3M_RS14730	COG3716	PTS system mannose fructose sorbose family IID component
I3M_RS14750	COG2226	methyltransferase
I3M_RS14785	COG1414	Transcriptional regulator
I3M_RS14790	COG2814	Major facilitator Superfamily
I3M_RS14800	COG0793	Belongs to the peptidase S41A family
I3M_RS14810	COG1956	GAF domain-containing protein
I3M_RS14815	COG2995	paraquat-inducible protein a
I3M_RS14820	COG3008	intermembrane lipid transfer
I3M_RS14840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3M_RS14870	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS14880	COG4372	Transposase
I3M_RS14885	COG3436	PFAM IS66 Orf2 family protein
I3M_RS14970	COG1030	water channel activity
I3M_RS14990	COG4220	transposase activity
I3M_RS15020	COG3772	lysozyme
I3M_RS15050	COG0484	heat shock protein binding
I3M_RS15055	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS15060	COG1403	HNH endonuclease
I3M_RS15070	COG3111	PFAM Bacterial OB fold (BOF) protein
I3M_RS15115	COG1846	Transcriptional regulator
I3M_RS15165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS15170	COG3723	Recombinational DNA repair protein, rece pathway
I3M_RS15190	COG0582	viral genome integration into host DNA
I3M_RS15200	COG1276	copper resistance
I3M_RS15205	COG2372	response to copper ion
I3M_RS15215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3M_RS15220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS15225	COG1770	oligopeptidase
I3M_RS15230	COG2979	Protein of unknown function (DUF533)
I3M_RS15240	COG3141	response to X-ray
I3M_RS15250	COG0800	Aldolase
I3M_RS15255	COG0129	dihydroxy-acid dehydratase activity
I3M_RS15260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I3M_RS15265	COG1737	Transcriptional regulator
I3M_RS15270	COG0469	pyruvate kinase activity
I3M_RS15295	COG3833	ABC-type maltose transport systems, permease component
I3M_RS15300	COG1175	transmembrane transport
I3M_RS15305	COG2182	Extracellular solute-binding protein
I3M_RS15315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3M_RS15325	COG3842	ATPase activity
I3M_RS15345	COG1560	Kdo2-lipid A biosynthetic process
I3M_RS15350	COG0739	heme binding
I3M_RS15355	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I3M_RS15365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3M_RS15395	COG0217	transcriptional regulatory protein
I3M_RS15400	COG0494	nUDIX hydrolase
I3M_RS15410	COG1335	isochorismatase
I3M_RS15415	COG1801	Protein of unknown function DUF72
I3M_RS15420	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I3M_RS15435	COG0243	molybdopterin cofactor binding
I3M_RS15440	COG3005	denitrification pathway
I3M_RS15450	COG3102	Protein conserved in bacteria
I3M_RS15465	COG3755	Protein conserved in bacteria
I3M_RS15475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3M_RS15480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3M_RS15485	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I3M_RS15490	COG0745	RESPONSE REGULATOR receiver
I3M_RS15495	COG2201	protein-glutamate methylesterase activity
I3M_RS15500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I3M_RS15505	COG0840	transmembrane signaling receptor activity
I3M_RS15510	COG0840	transmembrane signaling receptor activity
I3M_RS15515	COG0835	chemotaxis
I3M_RS15520	COG0643	Histidine kinase
I3M_RS15520	COG2198	Histidine kinase
I3M_RS15525	COG1360	Flagellar Motor Protein
I3M_RS15530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3M_RS15545	COG0589	response to stress
I3M_RS15555	COG1877	trehalose-phosphatase activity
I3M_RS15560	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS15565	COG1129	ABC transporter
I3M_RS15570	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS15580	COG1528	Iron-storage protein
I3M_RS15600	COG1528	Iron-storage protein
I3M_RS15610	COG0814	amino acid
I3M_RS15615	COG3318	Belongs to the UPF0149 family
I3M_RS15615	COG3012	SEC-C Motif Domain Protein
I3M_RS15645	COG2197	response regulator
I3M_RS15660	COG2197	response regulator
I3M_RS15665	COG1126	abc transporter atp-binding protein
I3M_RS15670	COG0765	amino acid transport
I3M_RS15680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS15690	COG1191	sigma factor activity
I3M_RS15705	COG1516	flagellar protein fliS
I3M_RS15715	COG0366	Alpha amylase catalytic
I3M_RS15730	COG2391	methyltransferase activity
I3M_RS15735	COG0425	Belongs to the sulfur carrier protein TusA family
I3M_RS15740	COG2135	peptidase activity
I3M_RS15760	COG1766	The M ring may be actively involved in energy transduction
I3M_RS15765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3M_RS15770	COG1317	bacterial-type flagellum organization
I3M_RS15775	COG1157	protein secretion by the type III secretion system
I3M_RS15780	COG2882	bacterial-type flagellum organization
I3M_RS15785	COG3144	bacterial-type flagellum assembly
I3M_RS15790	COG1580	Controls the rotational direction of flagella during chemotaxis
I3M_RS15795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3M_RS15800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3M_RS15805	COG3190	flagellar
I3M_RS15810	COG1338	Plays a role in the flagellum-specific transport system
I3M_RS15815	COG1987	bacterial-type flagellum assembly
I3M_RS15820	COG1684	flagellar biosynthetic protein fliR
I3M_RS15825	COG2197	response regulator
I3M_RS15860	COG5475	Uncharacterized small protein (DUF2158)
I3M_RS15865	COG2354	Protein conserved in bacteria
I3M_RS15870	COG0697	spore germination
I3M_RS15880	COG0270	DNA (cytosine-5-)-methyltransferase activity
I3M_RS15900	COG2205	protein histidine kinase activity
I3M_RS15905	COG0745	RESPONSE REGULATOR receiver
I3M_RS15910	COG2351	hydroxyisourate hydrolase activity
I3M_RS15925	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3M_RS15955	COG1169	isochorismate synthase
I3M_RS15960	COG2814	Major facilitator Superfamily
I3M_RS15965	COG1132	(ABC) transporter
I3M_RS15980	COG2226	methyltransferase
I3M_RS15980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3M_RS15980	COG3433	isochorismatase activity
I3M_RS16000	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3M_RS16005	COG4771	TonB-dependent receptor
I3M_RS16010	COG1388	LysM domain
I3M_RS16010	COG2373	Large extracellular alpha-helical protein
I3M_RS16010	COG4932	domain protein
I3M_RS16015	COG1470	cell adhesion involved in biofilm formation
I3M_RS16015	COG1388	LysM domain
I3M_RS16020	COG1388	LysM domain
I3M_RS16020	COG1470	cell adhesion involved in biofilm formation
I3M_RS16025	COG1388	LysM domain
I3M_RS16025	COG1470	cell adhesion involved in biofilm formation
I3M_RS16035	COG0477	Major facilitator Superfamily
I3M_RS16040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3M_RS16045	COG0217	transcriptional regulatory protein
I3M_RS16060	COG0534	Mate efflux family protein
I3M_RS16075	COG0583	DNA-binding transcription factor activity
I3M_RS16085	COG1376	ErfK ybiS ycfS ynhG family protein
I3M_RS16100	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I3M_RS16120	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3M_RS16185	COG4372	Transposase
I3M_RS16190	COG3436	PFAM IS66 Orf2 family protein
I3M_RS16215	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS16220	COG2020	methyltransferase activity
I3M_RS16230	COG4372	Transposase
I3M_RS16235	COG3436	PFAM IS66 Orf2 family protein
I3M_RS16270	COG2003	Belongs to the UPF0758 family
I3M_RS16310	COG4917	ethanolamine utilization protein
I3M_RS16320	COG1289	transmembrane transporter activity
I3M_RS16330	COG1686	Belongs to the peptidase S11 family
I3M_RS16335	COG2925	Exonuclease
I3M_RS16340	COG0425	Belongs to the sulfur carrier protein TusA family
I3M_RS16345	COG2391	methyltransferase activity
I3M_RS16350	COG0531	amino acid
I3M_RS16360	COG0583	DNA-binding transcription factor activity
I3M_RS16365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3M_RS16370	COG4115	mRNA cleavage
I3M_RS16375	COG2161	toxin-antitoxin pair type II binding
I3M_RS16395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3M_RS16405	COG0131	Imidazoleglycerol-phosphate dehydratase
I3M_RS16405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3M_RS16410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3M_RS16440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3M_RS16445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3M_RS16460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3M_RS16500	COG1091	dTDP-4-dehydrorhamnose reductase activity
I3M_RS16505	COG1088	dTDP-glucose 4,6-dehydratase activity
I3M_RS16515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3M_RS16525	COG0438	transferase activity, transferring glycosyl groups
I3M_RS16530	COG2327	Polysaccharide pyruvyl transferase
I3M_RS16535	COG2244	polysaccharide biosynthetic process
I3M_RS16540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3M_RS16545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3M_RS16550	COG0662	Cupin 2, conserved barrel domain protein
I3M_RS16550	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I3M_RS16555	COG0297	glycogen (starch) synthase activity
I3M_RS16560	COG1051	belongs to the nudix hydrolase family
I3M_RS16565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3M_RS16570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I3M_RS16575	COG0110	maltose O-acetyltransferase activity
I3M_RS16580	COG1216	Glycosyl transferase, family 2
I3M_RS16590	COG0438	transferase activity, transferring glycosyl groups
I3M_RS16595	COG1045	serine acetyltransferase
I3M_RS16600	COG0463	Glycosyl transferase, family 2
I3M_RS16605	COG3206	protein involved in exopolysaccharide biosynthesis
I3M_RS16605	COG0489	protein tyrosine kinase activity
I3M_RS16610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3M_RS16615	COG1596	polysaccharide export
I3M_RS16620	COG1253	flavin adenine dinucleotide binding
I3M_RS16625	COG2982	Protein involved in outer membrane biogenesis
I3M_RS16635	COG0572	uridine kinase
I3M_RS16645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I3M_RS16650	COG0443	Heat shock 70 kDa protein
I3M_RS16660	COG0631	protein serine/threonine phosphatase activity
I3M_RS16665	COG4245	von Willebrand factor, type A
I3M_RS16705	COG2205	protein histidine kinase activity
I3M_RS16710	COG0745	RESPONSE REGULATOR receiver
I3M_RS16720	COG3609	addiction module antidote protein, CC2985 family
I3M_RS16730	COG0826	peptidase U32
I3M_RS16760	COG3775	system Galactitol-specific IIC component
I3M_RS16765	COG3414	Phosphotransferase system galactitol-specific IIB component
I3M_RS16770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS16785	COG1830	Aldolase
I3M_RS16790	COG2211	Major facilitator Superfamily
I3M_RS16795	COG1397	ADP-ribosylglycohydrolase
I3M_RS16800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS16805	COG2188	Transcriptional regulator
I3M_RS16810	COG3757	hydrolase, family 25
I3M_RS16815	COG0351	phosphomethylpyrimidine kinase
I3M_RS16830	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I3M_RS16835	COG5455	response to cobalt ion
I3M_RS16840	COG3539	Fimbrial protein
I3M_RS16845	COG3188	usher protein
I3M_RS16850	COG3121	Chaperone
I3M_RS16855	COG3539	Fimbrial protein
I3M_RS16870	COG0489	protein tyrosine kinase activity
I3M_RS16885	COG3831	ATPase activity
I3M_RS16895	COG0714	Associated with various cellular activities
I3M_RS16900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I3M_RS16905	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3M_RS16910	COG4715	Zinc finger, swim domain protein
I3M_RS16920	COG3436	PFAM IS66 Orf2 family protein
I3M_RS16925	COG4372	Transposase
I3M_RS16935	COG4807	Protein conserved in bacteria
I3M_RS16940	COG3279	Response regulator of the LytR AlgR family
I3M_RS16945	COG3275	phosphorelay sensor kinase activity
I3M_RS16950	COG0789	Transcriptional regulator
I3M_RS16960	COG1174	glycine betaine transport
I3M_RS16965	COG1125	glycine betaine transport
I3M_RS16970	COG1174	glycine betaine transport
I3M_RS16975	COG1732	Glycine betaine
I3M_RS16980	COG1472	Belongs to the glycosyl hydrolase 3 family
I3M_RS16985	COG0277	FAD linked oxidase domain protein
I3M_RS16990	COG1686	Belongs to the peptidase S11 family
I3M_RS17000	COG0586	Pfam SNARE associated Golgi protein
I3M_RS17005	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS17030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3M_RS17040	COG1346	cytolysis
I3M_RS17050	COG2949	membrane
I3M_RS17060	COG0493	'glutamate synthase
I3M_RS17065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3M_RS17065	COG0167	dihydroorotate dehydrogenase activity
I3M_RS17070	COG4211	Belongs to the binding-protein-dependent transport system permease family
I3M_RS17075	COG1129	ABC transporter
I3M_RS17080	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS17085	COG1609	Transcriptional regulator
I3M_RS17095	COG2311	Membrane
I3M_RS17120	COG4771	TonB-dependent receptor
I3M_RS17130	COG0833	amino acid
I3M_RS17140	COG0583	DNA-binding transcription factor activity
I3M_RS17145	COG2855	membrane
I3M_RS17155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS17155	COG1522	sequence-specific DNA binding
I3M_RS17160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3M_RS17170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3M_RS17175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3M_RS17180	COG2313	pseudouridylate synthase activity
I3M_RS17185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS17190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS17190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I3M_RS17190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS17195	COG1105	Belongs to the carbohydrate kinase PfkB family
I3M_RS17200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS17200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS17205	COG2814	Major facilitator Superfamily
I3M_RS17220	COG0246	Mannitol dehydrogenase
I3M_RS17225	COG0523	cobalamin synthesis protein
I3M_RS17230	COG0671	phosphoesterase, PA-phosphatase related
I3M_RS17235	COG0791	NLP P60 protein
I3M_RS17240	COG2200	EAL domain
I3M_RS17245	COG4166	transmembrane transport
I3M_RS17250	COG4174	ABC transporter (Permease)
I3M_RS17255	COG4239	(ABC) transporter, permease
I3M_RS17260	COG4172	Belongs to the ABC transporter superfamily
I3M_RS17275	COG2814	Major facilitator Superfamily
I3M_RS17280	COG1187	pseudouridine synthase activity
I3M_RS17290	COG1061	Type III restriction enzyme res subunit
I3M_RS17310	COG3083	sulfuric ester hydrolase activity
I3M_RS17320	COG0582	viral genome integration into host DNA
I3M_RS17400	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS17415	COG2197	response regulator
I3M_RS17420	COG4235	cytochrome complex assembly
I3M_RS17420	COG3088	subunit of a heme lyase
I3M_RS17425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3M_RS17430	COG1138	Cytochrome C-type biogenesis protein
I3M_RS17440	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3M_RS17445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3M_RS17450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3M_RS17455	COG4133	protoheme IX ABC transporter activity
I3M_RS17460	COG3005	denitrification pathway
I3M_RS17465	COG3043	anaerobic respiration
I3M_RS17470	COG0348	domain, Protein
I3M_RS17475	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS17485	COG3062	negative regulation of establishment of protein localization
I3M_RS17490	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS17490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS17510	COG4615	Cyclic peptide transporter
I3M_RS17515	COG3145	DNA-N1-methyladenine dioxygenase activity
I3M_RS17520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3M_RS17520	COG2169	Transcriptional regulator
I3M_RS17525	COG1477	protein flavinylation
I3M_RS17530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3M_RS17545	COG0642	Histidine kinase
I3M_RS17545	COG2198	Histidine kinase
I3M_RS17550	COG2197	response regulator
I3M_RS17555	COG0784	Response regulator, receiver
I3M_RS17555	COG2205	protein histidine kinase activity
I3M_RS17560	COG4676	Protein conserved in bacteria
I3M_RS17565	COG5445	Predicted secreted protein (DUF2300)
I3M_RS17570	COG2373	Large extracellular alpha-helical protein
I3M_RS17605	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS17620	COG4372	Transposase
I3M_RS17625	COG3436	PFAM IS66 Orf2 family protein
I3M_RS17730	COG4220	transposase activity
I3M_RS17750	COG3772	lysozyme
I3M_RS17945	COG0582	viral genome integration into host DNA
I3M_RS17950	COG3234	Protein of unknown function (DUF1175)
I3M_RS17955	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I3M_RS17960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3M_RS17970	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS17980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3M_RS17985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3M_RS17990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3M_RS17995	COG3642	lipopolysaccharide core region biosynthetic process
I3M_RS18000	COG0583	DNA-binding transcription factor activity
I3M_RS18005	COG0584	glycerophosphoryl diester phosphodiesterase
I3M_RS18010	COG2271	Major facilitator Superfamily
I3M_RS18020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3M_RS18030	COG0247	lactate metabolic process
I3M_RS18035	COG5464	transposase or invertase
I3M_RS18105	COG0318	PFAM AMP-dependent synthetase and ligase
I3M_RS18115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3M_RS18130	COG1169	isochorismate synthase
I3M_RS18135	COG4575	ribosome binding
I3M_RS18140	COG2153	protein acetylation
I3M_RS18155	COG2304	oxidoreductase activity
I3M_RS18160	COG2234	aminopeptidase activity
I3M_RS18175	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3M_RS18180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3M_RS18190	COG0839	Belongs to the complex I subunit 6 family
I3M_RS18205	COG1034	ATP synthesis coupled electron transport
I3M_RS18210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3M_RS18215	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I3M_RS18235	COG0583	DNA-binding transcription factor activity
I3M_RS18245	COG0436	Aminotransferase
I3M_RS18255	COG0471	metal ion transport
I3M_RS18255	COG0490	domain, Protein
I3M_RS18260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3M_RS18275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3M_RS18280	COG0280	phosphate acetyltransferase
I3M_RS18280	COG0857	belongs to the CobB CobQ family
I3M_RS18285	COG1288	antiporter activity
I3M_RS18290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3M_RS18295	COG0622	Phosphoesterase
I3M_RS18300	COG0625	glutathione transferase activity
I3M_RS18305	COG0625	glutathione transferase activity
I3M_RS18310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3M_RS18315	COG1090	epimerase
I3M_RS18320	COG5464	transposase or invertase
I3M_RS18325	COG4598	ABC transporter
I3M_RS18330	COG4160	amino acid transport
I3M_RS18335	COG4215	(ABC) transporter
I3M_RS18340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS18345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS18350	COG0163	prenyltransferase activity
I3M_RS18355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I3M_RS18360	COG1286	toxin biosynthetic process
I3M_RS18365	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I3M_RS18370	COG0285	dihydrofolate synthase activity
I3M_RS18380	COG0586	Pfam SNARE associated Golgi protein
I3M_RS18390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3M_RS18405	COG2814	Major facilitator Superfamily
I3M_RS18415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3M_RS18430	COG3101	peptidyl-lysine hydroxylation
I3M_RS18435	COG0730	response to heat
I3M_RS18465	COG3539	Fimbrial protein
I3M_RS18470	COG3539	Fimbrial protein
I3M_RS18475	COG3539	Fimbrial protein
I3M_RS18480	COG3121	Chaperone
I3M_RS18485	COG3188	usher protein
I3M_RS18490	COG3539	Fimbrial protein
I3M_RS18495	COG2062	phosphohistidine phosphatase, SixA
I3M_RS18510	COG3691	Protein conserved in bacteria
I3M_RS18520	COG2067	long-chain fatty acid transport protein
I3M_RS18535	COG2853	Lipoprotein
I3M_RS18545	COG2116	formate transmembrane transporter activity
I3M_RS18555	COG0582	viral genome integration into host DNA
I3M_RS18560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3M_RS18635	COG1783	phage Terminase large subunit
I3M_RS18660	COG3646	Phage regulatory protein
I3M_RS18745	COG0305	Participates in initiation and elongation during chromosome replication
I3M_RS18910	COG3436	PFAM IS66 Orf2 family protein
I3M_RS18915	COG4372	Transposase
I3M_RS18970	COG3468	outer membrane autotransporter barrel domain protein
I3M_RS18990	COG2003	Belongs to the UPF0758 family
I3M_RS19035	COG0477	Major facilitator Superfamily
I3M_RS19040	COG1566	PFAM secretion protein HlyD family protein
I3M_RS19045	COG2197	response regulator
I3M_RS19050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS19050	COG2198	Histidine kinase
I3M_RS19050	COG2205	protein histidine kinase activity
I3M_RS19050	COG0784	Response regulator, receiver
I3M_RS19055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3M_RS19060	COG0679	Auxin Efflux Carrier
I3M_RS19065	COG0028	Belongs to the TPP enzyme family
I3M_RS19095	COG1560	Kdo2-lipid A biosynthetic process
I3M_RS19105	COG0436	Aminotransferase
I3M_RS19110	COG3275	phosphorelay sensor kinase activity
I3M_RS19115	COG3279	Response regulator of the LytR AlgR family
I3M_RS19120	COG2207	Transcriptional regulator
I3M_RS19130	COG1363	Peptidase, m42
I3M_RS19135	COG0006	proline dipeptidase activity
I3M_RS19140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS19145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS19170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3M_RS19175	COG2200	EAL domain
I3M_RS19175	COG2199	diguanylate cyclase activity
I3M_RS19190	COG3415	Transposase
I3M_RS19195	COG3415	Transposase
I3M_RS19225	COG0583	DNA-binding transcription factor activity
I3M_RS19235	COG2211	Major facilitator Superfamily
I3M_RS19240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3M_RS19250	COG0583	DNA-binding transcription factor activity
I3M_RS19255	COG0385	Bile acid
I3M_RS19260	COG3530	Putative quorum-sensing-regulated virulence factor
I3M_RS19280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3M_RS19285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS19290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3M_RS19295	COG2190	(PTS) system
I3M_RS19310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3M_RS19315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3M_RS19320	COG4208	sulfate ABC transporter
I3M_RS19325	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I3M_RS19330	COG4150	thiosulfate binding
I3M_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS19355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3M_RS19360	COG2837	iron assimilation
I3M_RS19380	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3M_RS19390	COG2207	Transcriptional regulator
I3M_RS19395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3M_RS19400	COG4816	utilization protein
I3M_RS19410	COG4303	Ethanolamine ammonia lyase large subunit
I3M_RS19415	COG4819	ethanolamine utilization protein
I3M_RS19420	COG3192	ethanolamine utilization protein
I3M_RS19425	COG1454	alcohol dehydrogenase
I3M_RS19430	COG4820	ethanolamine utilization protein (EutJ)
I3M_RS19435	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS19440	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I3M_RS19445	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3M_RS19450	COG0280	phosphate acetyltransferase
I3M_RS19455	COG4812	Cobalamin adenosyltransferase
I3M_RS19460	COG4766	ethanolamine catabolic process
I3M_RS19465	COG4917	ethanolamine utilization protein
I3M_RS19470	COG4810	utilization protein
I3M_RS19480	COG0280	phosphate acetyltransferase
I3M_RS19480	COG0281	malic enzyme
I3M_RS19485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3M_RS19490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3M_RS19495	COG5342	invasion associated locus B
I3M_RS19505	COG0493	'glutamate synthase
I3M_RS19505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS19510	COG3850	Histidine kinase
I3M_RS19515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3M_RS19530	COG1393	Belongs to the ArsC family
I3M_RS19545	COG0400	carboxylic ester hydrolase activity
I3M_RS19555	COG2321	neutral zinc metallopeptidase
I3M_RS19575	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I3M_RS19585	COG2716	regulation of RNA biosynthetic process
I3M_RS19590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I3M_RS19595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS19600	COG0651	ATP synthesis coupled electron transport
I3M_RS19605	COG0650	Formate hydrogenlyase subunit 4
I3M_RS19610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3M_RS19615	COG4237	Hydrogenase 4 membrane
I3M_RS19620	COG0651	ATP synthesis coupled electron transport
I3M_RS19625	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I3M_RS19625	COG3261	NADH dehydrogenase
I3M_RS19630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3M_RS19645	COG3604	Transcriptional regulator
I3M_RS19650	COG2116	formate transmembrane transporter activity
I3M_RS19660	COG0628	permease
I3M_RS19665	COG4783	chaperone-mediated protein folding
I3M_RS19670	COG1393	Belongs to the ArsC family
I3M_RS19680	COG2233	PERMEase
I3M_RS19700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I3M_RS19705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3M_RS19710	COG0248	Ppx GppA phosphatase
I3M_RS19715	COG2200	EAL domain
I3M_RS19735	COG3133	Outer membrane lipoprotein
I3M_RS19750	COG0516	GMP reductase activity
I3M_RS19750	COG0517	IMP dehydrogenase activity
I3M_RS19760	COG1645	bacterial-type flagellum-dependent swarming motility
I3M_RS19775	COG2976	Protein conserved in bacteria
I3M_RS19810	COG4953	penicillin-binding protein 1C
I3M_RS19815	COG2373	Large extracellular alpha-helical protein
I3M_RS19820	COG2897	thiosulfate sulfurtransferase activity
I3M_RS19835	COG2975	iron-sulfur cluster assembly
I3M_RS19840	COG0633	Ferredoxin
I3M_RS19860	COG0822	iron-sulfur transferase activity
I3M_RS19880	COG0483	inositol monophosphate 1-phosphatase activity
I3M_RS19885	COG1073	alpha beta
I3M_RS19890	COG3711	transcriptional antiterminator
I3M_RS19895	COG2814	Major facilitator Superfamily
I3M_RS19900	COG0583	DNA-binding transcription factor activity
I3M_RS19905	COG4638	Rieske (2fe-2S)
I3M_RS19930	COG2259	Doxx family
I3M_RS19935	COG2017	converts alpha-aldose to the beta-anomer
I3M_RS19940	COG1063	alcohol dehydrogenase
I3M_RS19945	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS19950	COG1129	ABC transporter
I3M_RS19955	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS19960	COG0457	Tetratricopeptide repeat
I3M_RS19965	COG1940	carbohydrate kinase activity
I3M_RS19975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3M_RS19975	COG1017	nitric oxide dioxygenase activity
I3M_RS19980	COG0347	Belongs to the P(II) protein family
I3M_RS19985	COG2204	response regulator
I3M_RS19990	COG3170	Tfp pilus assembly protein FimV
I3M_RS19995	COG2205	protein histidine kinase activity
I3M_RS20000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3M_RS20000	COG0047	phosphoribosylformylglycinamidine synthase activity
I3M_RS20020	COG0560	Phosphoserine phosphatase
I3M_RS20025	COG1737	Transcriptional regulator
I3M_RS20030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS20055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I3M_RS20080	COG0681	Belongs to the peptidase S26 family
I3M_RS20090	COG3086	response to oxidative stress
I3M_RS20095	COG3026	antisigma factor binding
I3M_RS20100	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I3M_RS20105	COG1595	DNA-templated transcription, initiation
I3M_RS20110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3M_RS20120	COG0513	Belongs to the DEAD box helicase family
I3M_RS20125	COG0583	DNA-binding transcription factor activity
I3M_RS20145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3M_RS20155	COG3118	belongs to the thioredoxin family
I3M_RS20160	COG3148	PFAM DTW domain containing protein
I3M_RS20165	COG0045	succinate-CoA ligase (ADP-forming) activity
I3M_RS20165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3M_RS20165	COG1042	CoA-binding domain protein
I3M_RS20170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3M_RS20175	COG5544	Lipoprotein
I3M_RS20180	COG0477	Major facilitator Superfamily
I3M_RS20210	COG0542	response to heat
I3M_RS20215	COG1496	oxidoreductase activity
I3M_RS20220	COG0564	pseudouridine synthase activity
I3M_RS20225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3M_RS20235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3M_RS20245	COG1605	Chorismate mutase
I3M_RS20245	COG0077	Prephenate dehydratase
I3M_RS20250	COG0287	Prephenate dehydrogenase
I3M_RS20250	COG1605	Chorismate mutase
I3M_RS20255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3M_RS20270	COG2199	diguanylate cyclase activity
I3M_RS20275	COG2885	chlorophyll binding
I3M_RS20300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I3M_RS20305	COG4137	Cytochrome C assembly protein
I3M_RS20310	COG4536	flavin adenine dinucleotide binding
I3M_RS20330	COG0497	DNA recombination
I3M_RS20335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3M_RS20345	COG2867	negative regulation of translational initiation
I3M_RS20390	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3M_RS20525	COG3772	lysozyme
I3M_RS20570	COG0484	heat shock protein binding
I3M_RS20575	COG1403	HNH endonuclease
I3M_RS20585	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3M_RS20595	COG4725	Belongs to the MT-A70-like family
I3M_RS20605	COG1846	Transcriptional regulator
I3M_RS20615	COG3646	Phage regulatory protein
I3M_RS20625	COG4197	protein conserved in bacteria, prophage-related
I3M_RS20630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3M_RS20650	COG5532	Uncharacterized conserved protein (DUF2303)
I3M_RS20655	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I3M_RS20700	COG0582	viral genome integration into host DNA
I3M_RS20710	COG0582	viral genome integration into host DNA
I3M_RS20745	COG0579	oxidoreductase
I3M_RS20750	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS20755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3M_RS20760	COG1113	amino acid transport
I3M_RS20765	COG1802	Transcriptional regulator
I3M_RS20770	COG1652	LysM domain
I3M_RS20775	COG0401	homolog of Blt101
I3M_RS20780	COG0640	Transcriptional regulator
I3M_RS20785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3M_RS20790	COG2916	Histone family protein nucleoid-structuring protein H-NS
I3M_RS20805	COG4575	ribosome binding
I3M_RS20810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3M_RS20820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3M_RS20825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3M_RS20830	COG4175	Glycine betaine
I3M_RS20835	COG4176	ABC-type proline glycine betaine transport system permease component
I3M_RS20840	COG2113	Glycine betaine
I3M_RS20845	COG2814	Major facilitator Superfamily
I3M_RS20850	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3M_RS20860	COG1846	Transcriptional regulator
I3M_RS20865	COG1566	PFAM secretion protein HlyD family protein
I3M_RS20870	COG2814	Major facilitator Superfamily
I3M_RS20885	COG1238	metal cluster binding
I3M_RS20890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3M_RS20920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I3M_RS20940	COG1546	Belongs to the CinA family
I3M_RS20945	COG2951	lytic endotransglycosylase activity
I3M_RS20950	COG3730	PTS system glucitol sorbitol-specific
I3M_RS20955	COG3732	PTS system glucitol sorbitol-specific
I3M_RS20965	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS20970	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS20975	COG1349	DNA-binding transcription factor activity
I3M_RS21000	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3M_RS21005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS21010	COG1609	Transcriptional regulator
I3M_RS21015	COG1263	PTS System
I3M_RS21015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS21020	COG2723	6-phospho-beta-galactosidase activity
I3M_RS21025	COG5499	transcription regulator containing HTH domain
I3M_RS21030	COG4680	protein conserved in bacteria
I3M_RS21040	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3M_RS21050	COG3260	NADH ubiquinone oxidoreductase 20
I3M_RS21055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3M_RS21060	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I3M_RS21060	COG3261	NADH dehydrogenase
I3M_RS21065	COG0650	Formate hydrogenlyase subunit 4
I3M_RS21070	COG0651	ATP synthesis coupled electron transport
I3M_RS21075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS21085	COG0375	protein maturation
I3M_RS21090	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3M_RS21095	COG0298	carbon dioxide binding
I3M_RS21100	COG0409	Hydrogenase expression formation protein
I3M_RS21105	COG0309	Hydrogenase expression formation protein (HypE)
I3M_RS21110	COG3604	Transcriptional regulator
I3M_RS21125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3M_RS21130	COG1349	DNA-binding transcription factor activity
I3M_RS21135	COG2084	Dehydrogenase
I3M_RS21140	COG3395	kinase activity
I3M_RS21145	COG0235	Class ii aldolase
I3M_RS21150	COG3622	Belongs to the hyi family
I3M_RS21155	COG2610	gluconate transmembrane transporter activity
I3M_RS21165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3M_RS21180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3M_RS21185	COG1388	LysM domain
I3M_RS21185	COG4942	peptidase
I3M_RS21240	COG2234	aminopeptidase activity
I3M_RS21245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3M_RS21250	COG1518	maintenance of DNA repeat elements
I3M_RS21265	COG1857	crispr-associated protein
I3M_RS21310	COG0720	synthase
I3M_RS21315	COG0644	oxidoreductase
I3M_RS21320	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3M_RS21325	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3M_RS21330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3M_RS21335	COG2086	electron transfer activity
I3M_RS21345	COG0277	FAD linked oxidase domain protein
I3M_RS21350	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS21360	COG2223	nitrite transmembrane transporter activity
I3M_RS21365	COG1070	Carbohydrate kinase
I3M_RS21370	COG0602	queuosine metabolic process
I3M_RS21380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I3M_RS21395	COG3956	TIGRFAM MazG family protein
I3M_RS21400	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3M_RS21405	COG2336	PFAM SpoVT AbrB
I3M_RS21410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3M_RS21420	COG2205	protein histidine kinase activity
I3M_RS21420	COG3437	response regulator, receiver
I3M_RS21420	COG3850	Histidine kinase
I3M_RS21420	COG4999	Histidine kinase
I3M_RS21425	COG4948	Mandelate Racemase Muconate Lactonizing
I3M_RS21430	COG4948	Mandelate Racemase Muconate Lactonizing
I3M_RS21435	COG2271	Major facilitator Superfamily
I3M_RS21440	COG0716	FMN binding
I3M_RS21445	COG0564	pseudouridine synthase activity
I3M_RS21450	COG3098	single-species biofilm formation
I3M_RS21465	COG1611	Belongs to the LOG family
I3M_RS21470	COG0814	amino acid
I3M_RS21475	COG1760	l-serine dehydratase
I3M_RS21485	COG1454	alcohol dehydrogenase
I3M_RS21490	COG0235	Class ii aldolase
I3M_RS21495	COG0738	Major facilitator superfamily
I3M_RS21505	COG1070	Carbohydrate kinase
I3M_RS21515	COG1349	DNA-binding transcription factor activity
I3M_RS21525	COG2363	Small membrane protein
I3M_RS21530	COG0583	DNA-binding transcription factor activity
I3M_RS21540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3M_RS21545	COG2166	iron-sulfur cluster assembly
I3M_RS21550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I3M_RS21555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I3M_RS21590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3M_RS21595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS21595	COG1263	PTS System
I3M_RS21600	COG3711	transcriptional antiterminator
I3M_RS21605	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3M_RS21615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3M_RS21615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3M_RS21620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3M_RS21625	COG1074	ATP-dependent DNA helicase activity
I3M_RS21630	COG1025	Belongs to the peptidase M16 family
I3M_RS21635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3M_RS21640	COG4967	type IV pilus modification protein PilV
I3M_RS21650	COG4795	General secretion pathway protein
I3M_RS21655	COG2165	general secretion pathway protein
I3M_RS21670	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I3M_RS21685	COG0861	Integral membrane protein TerC family
I3M_RS21695	COG0667	Aldo Keto reductase
I3M_RS21710	COG1609	Transcriptional regulator
I3M_RS21720	COG0583	DNA-binding transcription factor activity
I3M_RS21725	COG1794	racemase activity, acting on amino acids and derivatives
I3M_RS21730	COG2814	Major facilitator Superfamily
I3M_RS21735	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS21745	COG0183	Belongs to the thiolase family
I3M_RS21750	COG0814	amino acid
I3M_RS21755	COG2771	luxR family
I3M_RS21760	COG3710	Transcriptional regulator
I3M_RS21785	COG0457	Tetratricopeptide repeat
I3M_RS21790	COG0457	Tetratricopeptide repeat
I3M_RS21790	COG3710	Transcriptional regulator
I3M_RS21805	COG2197	response regulator
I3M_RS21810	COG2197	response regulator
I3M_RS21895	COG3387	PFAM Glycoside hydrolase 15-related
I3M_RS21910	COG4372	Transposase
I3M_RS21915	COG3436	PFAM IS66 Orf2 family protein
I3M_RS21950	COG4974	Belongs to the 'phage' integrase family
I3M_RS21960	COG4942	peptidase
I3M_RS21970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3M_RS21975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3M_RS21980	COG2080	2 iron, 2 sulfur cluster binding
I3M_RS21985	COG3829	transcription factor binding
I3M_RS21990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3M_RS21995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3M_RS22000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3M_RS22010	COG0549	Belongs to the carbamate kinase family
I3M_RS22015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3M_RS22015	COG3608	succinylglutamate desuccinylase aspartoacylase
I3M_RS22020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3M_RS22025	COG2068	MobA-Related Protein
I3M_RS22030	COG0493	'glutamate synthase
I3M_RS22030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS22035	COG0402	S-adenosylhomocysteine deaminase activity
I3M_RS22040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3M_RS22045	COG2080	2 iron, 2 sulfur cluster binding
I3M_RS22045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3M_RS22050	COG2233	PERMEase
I3M_RS22055	COG0402	S-adenosylhomocysteine deaminase activity
I3M_RS22060	COG2252	PERMEase
I3M_RS22065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS22070	COG0493	'glutamate synthase
I3M_RS22070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS22080	COG2233	PERMEase
I3M_RS22105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I3M_RS22110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3M_RS22115	COG4974	Belongs to the 'phage' integrase family
I3M_RS22120	COG0716	FMN binding
I3M_RS22130	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I3M_RS22140	COG1272	protein, Hemolysin III
I3M_RS22150	COG2723	6-phospho-beta-galactosidase activity
I3M_RS22155	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS22175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3M_RS22180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3M_RS22185	COG0006	proline dipeptidase activity
I3M_RS22210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3M_RS22230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3M_RS22250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3M_RS22250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3M_RS22255	COG1703	isobutyryl-CoA mutase activity
I3M_RS22260	COG1024	Enoyl-CoA hydratase
I3M_RS22265	COG0427	acetyl-CoA hydrolase
I3M_RS22270	COG0583	DNA-binding transcription factor activity
I3M_RS22275	COG2968	Membrane
I3M_RS22285	COG0668	transmembrane transport
I3M_RS22295	COG0191	fructose-bisphosphate aldolase activity
I3M_RS22330	COG1122	ATPase activity
I3M_RS22335	COG1122	ATPase activity
I3M_RS22340	COG1072	(Pantothenic acid kinase))
I3M_RS22350	COG1494	fructose-1,6-bisphosphatase
I3M_RS22355	COG1063	alcohol dehydrogenase
I3M_RS22360	COG2213	PTS system mannitol-specific
I3M_RS22365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS22370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3M_RS22375	COG0501	Belongs to the peptidase M48B family
I3M_RS22390	COG3716	PTS system mannose fructose sorbose family IID component
I3M_RS22395	COG3715	PTS system
I3M_RS22400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS22400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS22425	COG1166	arginine decarboxylase activity
I3M_RS22450	COG2814	Major facilitator Superfamily
I3M_RS22460	COG2356	endonuclease I
I3M_RS22465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3M_RS22470	COG0189	ligase activity
I3M_RS22485	COG2805	Type II/IV secretion system protein
I3M_RS22490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3M_RS22495	COG0762	integral membrane protein
I3M_RS22510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3M_RS22515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3M_RS22520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3M_RS22535	COG0252	asparaginase activity
I3M_RS22545	COG3171	Protein conserved in bacteria
I3M_RS22560	COG1194	a g-specific adenine glycosylase
I3M_RS22575	COG2211	Major facilitator Superfamily
I3M_RS22580	COG1982	Orn Lys Arg decarboxylase major
I3M_RS22590	COG1811	Na channel or pump
I3M_RS22600	COG0582	viral genome integration into host DNA
I3M_RS22620	COG4771	TonB-dependent receptor
I3M_RS22640	COG2194	sulfuric ester hydrolase activity
I3M_RS22650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3M_RS22655	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I3M_RS22660	COG0247	lactate metabolic process
I3M_RS22665	COG0277	FAD linked oxidase domain protein
I3M_RS22670	COG0277	FAD linked oxidase domain protein
I3M_RS22675	COG2186	Transcriptional regulator
I3M_RS22680	COG0456	acetyltransferase
I3M_RS22690	COG0318	PFAM AMP-dependent synthetase and ligase
I3M_RS22700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3M_RS22705	COG0156	8-amino-7-oxononanoate synthase activity
I3M_RS22715	COG0795	lipopolysaccharide-transporting ATPase activity
I3M_RS22720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3M_RS22730	COG2244	polysaccharide biosynthetic process
I3M_RS22735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3M_RS22740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3M_RS22745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3M_RS22750	COG0306	phosphate transporter
I3M_RS22755	COG0754	glutathionylspermidine amidase activity
I3M_RS22760	COG0625	glutathione transferase activity
I3M_RS22770	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS22775	COG0298	carbon dioxide binding
I3M_RS22785	COG1773	rubredoxin
I3M_RS22790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3M_RS22795	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I3M_RS22800	COG5557	Pfam Polysulphide reductase, NrfD
I3M_RS22805	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS22810	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I3M_RS22830	COG0667	Aldo Keto reductase
I3M_RS22840	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS22845	COG0848	biopolymer transport protein
I3M_RS22850	COG0811	peptide transport
I3M_RS22860	COG0626	cystathionine gamma-synthase activity
I3M_RS22865	COG0586	Pfam SNARE associated Golgi protein
I3M_RS22870	COG2207	Transcriptional regulator
I3M_RS22875	COG1979	alcohol dehydrogenase
I3M_RS22880	COG0656	L-ascorbic acid biosynthetic process
I3M_RS22890	COG4238	major outer membrane lipoprotein
I3M_RS22895	COG1032	radical SAM domain protein
I3M_RS22900	COG2132	Multicopper oxidase
I3M_RS22905	COG0204	Acyl-transferase
I3M_RS22910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3M_RS22920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3M_RS22925	COG3111	PFAM Bacterial OB fold (BOF) protein
I3M_RS22930	COG0745	RESPONSE REGULATOR receiver
I3M_RS22935	COG0642	Histidine kinase
I3M_RS22945	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3M_RS22950	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I3M_RS22955	COG0187	DNA topoisomerase II activity
I3M_RS22960	COG3150	esterase
I3M_RS22965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3M_RS22970	COG3151	Protein conserved in bacteria
I3M_RS22975	COG0494	nUDIX hydrolase
I3M_RS22980	COG1538	Outer membrane efflux protein
I3M_RS22995	COG0754	glutathionylspermidine amidase activity
I3M_RS23000	COG3384	dioxygenase
I3M_RS23020	COG2960	long-chain fatty acid transporting porin activity
I3M_RS23025	COG3539	Fimbrial protein
I3M_RS23030	COG3188	usher protein
I3M_RS23035	COG3121	Chaperone
I3M_RS23050	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3M_RS23085	COG3025	triphosphatase activity
I3M_RS23095	COG4991	sh3 domain protein
I3M_RS23110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3M_RS23120	COG0583	DNA-binding transcription factor activity
I3M_RS23130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3M_RS23135	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3M_RS23140	COG0471	metal ion transport
I3M_RS23155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I3M_RS23160	COG0358	DNA primase activity
I3M_RS23170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3M_RS23185	COG2375	cellular response to nickel ion
I3M_RS23195	COG1695	Transcriptional regulator
I3M_RS23200	COG0840	transmembrane signaling receptor activity
I3M_RS23215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3M_RS23225	COG1609	Transcriptional regulator
I3M_RS23230	COG3250	beta-galactosidase activity
I3M_RS23235	COG2731	YhcH YjgK YiaL family protein
I3M_RS23240	COG0531	amino acid
I3M_RS23255	COG1902	pentaerythritol trinitrate reductase activity
I3M_RS23255	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3M_RS23260	COG5499	transcription regulator containing HTH domain
I3M_RS23265	COG4680	protein conserved in bacteria
I3M_RS23275	COG1451	nucleotide metabolic process
I3M_RS23285	COG0673	inositol 2-dehydrogenase activity
I3M_RS23290	COG0861	Integral membrane protein TerC family
I3M_RS23295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I3M_RS23305	COG2721	sulfolactate sulfo-lyase activity
I3M_RS23315	COG2271	Major facilitator Superfamily
I3M_RS23345	COG2186	Transcriptional regulator
I3M_RS23350	COG0586	Pfam SNARE associated Golgi protein
I3M_RS23360	COG1422	Protein of unknown function (DUF1090)
I3M_RS23365	COG4575	ribosome binding
I3M_RS23370	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I3M_RS23380	COG2259	Doxx family
I3M_RS23385	COG0435	Glutathione S-transferase
I3M_RS23390	COG3152	Membrane
I3M_RS23395	COG3152	Membrane
I3M_RS23405	COG0583	DNA-binding transcription factor activity
I3M_RS23410	COG1741	Belongs to the pirin family
I3M_RS23425	COG0814	amino acid
I3M_RS23435	COG1760	l-serine dehydratase
I3M_RS23440	COG0251	oxidation-reduction process
I3M_RS23445	COG1882	Formate acetyltransferase
I3M_RS23450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3M_RS23460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3M_RS23470	COG0583	DNA-binding transcription factor activity
I3M_RS23495	COG1929	Belongs to the glycerate kinase type-1 family
I3M_RS23500	COG2084	Dehydrogenase
I3M_RS23510	COG2271	Major facilitator Superfamily
I3M_RS23515	COG2721	sulfolactate sulfo-lyase activity
I3M_RS23520	COG2002	toxin-antitoxin pair type II binding
I3M_RS23530	COG1349	DNA-binding transcription factor activity
I3M_RS23545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS23555	COG3716	PTS system mannose fructose sorbose family IID component
I3M_RS23560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS23565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3M_RS23570	COG2222	sugar isomerase
I3M_RS23580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS23585	COG3715	PTS system
I3M_RS23590	COG3716	PTS system mannose fructose sorbose family IID component
I3M_RS23595	COG0363	glucosamine-6-phosphate deaminase activity
I3M_RS23600	COG3539	Fimbrial protein
I3M_RS23605	COG3121	Chaperone
I3M_RS23610	COG3188	usher protein
I3M_RS23615	COG3539	Fimbrial protein
I3M_RS23620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I3M_RS23640	COG2823	Periplasmic or secreted lipoprotein
I3M_RS23645	COG0701	Predicted permease
I3M_RS23650	COG0702	epimerase
I3M_RS23655	COG0693	protein deglycase activity
I3M_RS23670	COG3153	acetyltransferase
I3M_RS23675	COG3154	lipid carrier protein
I3M_RS23680	COG0826	peptidase U32
I3M_RS23685	COG0826	peptidase U32
I3M_RS23690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3M_RS23695	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS23705	COG0814	amino acid
I3M_RS23710	COG0513	Belongs to the DEAD box helicase family
I3M_RS23750	COG0195	Participates in both transcription termination and antitermination
I3M_RS23770	COG2194	sulfuric ester hydrolase activity
I3M_RS23780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3M_RS23790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3M_RS23795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3M_RS23805	COG1534	Rna-binding protein
I3M_RS23810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3M_RS23815	COG2027	D-alanyl-D-alanine carboxypeptidase
I3M_RS23825	COG0697	spore germination
I3M_RS23840	COG0142	geranyltranstransferase activity
I3M_RS23845	COG3423	Transcriptional regulator
I3M_RS23855	COG5007	Belongs to the BolA IbaG family
I3M_RS23860	COG3113	response to antibiotic
I3M_RS23865	COG2854	intermembrane phospholipid transfer
I3M_RS23870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3M_RS23875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3M_RS23880	COG1127	ABC transporter
I3M_RS23885	COG0530	calcium, potassium:sodium antiporter activity
I3M_RS23890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3M_RS23890	COG0517	IMP dehydrogenase activity
I3M_RS23895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I3M_RS23900	COG3117	lipopolysaccharide transmembrane transporter activity
I3M_RS23905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I3M_RS23910	COG1137	ATPase activity
I3M_RS23915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I3M_RS23920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3M_RS23935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS23940	COG0515	serine threonine protein kinase
I3M_RS23950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I3M_RS23955	COG2198	Histidine kinase
I3M_RS23955	COG0784	Response regulator, receiver
I3M_RS23955	COG5002	protein histidine kinase activity
I3M_RS23960	COG1242	4 iron, 4 sulfur cluster binding
I3M_RS23975	COG0069	glutamate synthase activity
I3M_RS23975	COG0070	glutamate synthase
I3M_RS23975	COG0067	glutamate synthase
I3M_RS23980	COG0493	'glutamate synthase
I3M_RS23990	COG2731	YhcH YjgK YiaL family protein
I3M_RS24025	COG3069	C4-dicarboxylate transmembrane transporter activity
I3M_RS24030	COG2969	positive regulation of protein catabolic process
I3M_RS24035	COG0625	glutathione transferase activity
I3M_RS24060	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I3M_RS24065	COG3105	Protein conserved in bacteria
I3M_RS24070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3M_RS24075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3M_RS24115	COG0583	DNA-binding transcription factor activity
I3M_RS24120	COG0312	modulator of DNA gyrase
I3M_RS24125	COG3164	Protein of unknown function
I3M_RS24130	COG1530	ribonuclease E activity
I3M_RS24140	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I3M_RS24145	COG1792	Involved in formation and maintenance of cell shape
I3M_RS24150	COG1077	Cell shape determining protein MreB Mrl
I3M_RS24165	COG2199	diguanylate cyclase activity
I3M_RS24165	COG2200	EAL domain
I3M_RS24170	COG0604	alcohol dehydrogenase
I3M_RS24185	COG0511	ligase activity, forming carbon-carbon bonds
I3M_RS24190	COG0439	Biotin carboxylase
I3M_RS24200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS24205	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS24210	COG1129	ABC transporter
I3M_RS24215	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS24225	COG1349	DNA-binding transcription factor activity
I3M_RS24230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS24235	COG3924	membrane
I3M_RS24240	COG4145	pantothenate transmembrane transporter activity
I3M_RS24250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3M_RS24260	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I3M_RS24270	COG1309	transcriptional regulator
I3M_RS24280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS24285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3M_RS24300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3M_RS24320	COG0765	amino acid transport
I3M_RS24325	COG1126	abc transporter atp-binding protein
I3M_RS24370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3M_RS24390	COG0551	DNA topoisomerase type I activity
I3M_RS24400	COG0758	DNA mediated transformation
I3M_RS24420	COG0569	domain protein
I3M_RS24430	COG3036	rescue of stalled ribosome
I3M_RS24435	COG0789	Transcriptional regulator
I3M_RS24475	COG0201	protein transport
I3M_RS24565	COG0089	rRNA binding
I3M_RS24645	COG2964	Protein conserved in bacteria
I3M_RS24650	COG0545	Peptidyl-prolyl cis-trans isomerase
I3M_RS24660	COG1047	Peptidyl-prolyl cis-trans
I3M_RS24665	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I3M_RS24685	COG0488	(ABC) transporter
I3M_RS24690	COG0429	hydrolase of the alpha beta-hydrolase fold
I3M_RS24700	COG3954	Phosphoribulokinase
I3M_RS24705	COG1765	OsmC-like protein
I3M_RS24715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3M_RS24720	COG1289	transmembrane transporter activity
I3M_RS24725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3M_RS24730	COG0512	Glutamine amidotransferase of anthranilate synthase
I3M_RS24735	COG2184	nucleotidyltransferase activity
I3M_RS24745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3M_RS24755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3M_RS24760	COG2146	nitrite reductase [NAD(P)H] activity
I3M_RS24765	COG2116	formate transmembrane transporter activity
I3M_RS24780	COG0531	amino acid
I3M_RS24785	COG2222	sugar isomerase
I3M_RS24795	COG1082	Xylose isomerase domain protein TIM barrel
I3M_RS24805	COG2188	Transcriptional regulator
I3M_RS24810	COG0626	cystathionine gamma-synthase activity
I3M_RS24825	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3M_RS24830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I3M_RS24835	COG3457	Alanine racemase
I3M_RS24845	COG2188	Transcriptional regulator
I3M_RS24850	COG0180	Tryptophanyl-tRNA synthetase
I3M_RS24855	COG0546	phosphoglycolate phosphatase activity
I3M_RS24860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3M_RS24865	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I3M_RS24870	COG3266	domain, Protein
I3M_RS24890	COG4796	Type ii and iii secretion system protein
I3M_RS24905	COG3166	PFAM Fimbrial assembly family protein
I3M_RS24910	COG4972	Pilus assembly protein
I3M_RS24915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3M_RS24920	COG0494	nUDIX hydrolase
I3M_RS24930	COG1011	Hydrolase
I3M_RS24935	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I3M_RS24945	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3M_RS24975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3M_RS24980	COG2183	response to ionizing radiation
I3M_RS24990	COG1918	ferrous iron import across plasma membrane
I3M_RS24995	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I3M_RS25010	COG5464	transposase or invertase
I3M_RS25030	COG2610	gluconate transmembrane transporter activity
I3M_RS25035	COG1640	4-alpha-glucanotransferase
I3M_RS25040	COG0058	SHG alpha-glucan phosphorylase activity
I3M_RS25055	COG1690	Belongs to the RtcB family
I3M_RS25060	COG4650	regulator
I3M_RS25065	COG1349	DNA-binding transcription factor activity
I3M_RS25080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3M_RS25100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3M_RS25105	COG0058	SHG alpha-glucan phosphorylase activity
I3M_RS25130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3M_RS25135	COG2095	MarC family integral membrane protein
I3M_RS25140	COG2610	gluconate transmembrane transporter activity
I3M_RS25145	COG3265	gluconokinase activity
I3M_RS25150	COG1609	Transcriptional regulator
I3M_RS25155	COG1741	Belongs to the pirin family
I3M_RS25160	COG0673	inositol 2-dehydrogenase activity
I3M_RS25170	COG1247	-acetyltransferase
I3M_RS25175	COG3157	Type VI secretion system effector, Hcp
I3M_RS25195	COG0405	Gamma-glutamyltransferase
I3M_RS25205	COG0584	glycerophosphoryl diester phosphodiesterase
I3M_RS25210	COG3842	ATPase activity
I3M_RS25220	COG1175	transmembrane transport
I3M_RS25225	COG1653	transport
I3M_RS25230	COG0410	ABC transporter
I3M_RS25235	COG0411	ABC transporter
I3M_RS25240	COG4177	L-phenylalanine transmembrane transporter activity
I3M_RS25245	COG0559	Belongs to the binding-protein-dependent transport system permease family
I3M_RS25250	COG0683	leucine binding
I3M_RS25255	COG0456	acetyltransferase
I3M_RS25260	COG0683	leucine binding
I3M_RS25265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3M_RS25270	COG2177	Part of the ABC transporter FtsEX involved in
I3M_RS25275	COG2884	Cell division ATP-binding protein ftsE
I3M_RS25280	COG0552	protein localization to endoplasmic reticulum
I3M_RS25285	COG0742	ribosomal rna small subunit methyltransferase
I3M_RS25290	COG3776	membrane
I3M_RS25300	COG3714	YhhN family
I3M_RS25315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I3M_RS25330	COG0628	permease
I3M_RS25335	COG2091	lysine biosynthetic process via aminoadipic acid
I3M_RS25340	COG0747	negative chemotaxis
I3M_RS25345	COG0601	transmembrane transport
I3M_RS25350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3M_RS25355	COG0444	Belongs to the ABC transporter superfamily
I3M_RS25370	COG3209	COG3209 Rhs family protein
I3M_RS25380	COG1413	lyase activity
I3M_RS25390	COG0842	Transport permease protein
I3M_RS25395	COG0842	Transport permease protein
I3M_RS25395	COG1129	ABC transporter
I3M_RS25400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS25425	COG2081	HI0933 family
I3M_RS25430	COG0306	phosphate transporter
I3M_RS25440	COG0589	response to stress
I3M_RS25450	COG3104	oligopeptide transport
I3M_RS25460	COG0339	signal peptide processing
I3M_RS25465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I3M_RS25470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3M_RS25485	COG0640	Transcriptional regulator
I3M_RS25490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3M_RS25495	COG1393	Belongs to the ArsC family
I3M_RS25515	COG3065	identical protein binding
I3M_RS25530	COG1285	pathogenesis
I3M_RS25545	COG3247	response to pH
I3M_RS25550	COG2771	luxR family
I3M_RS25560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3M_RS25565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3M_RS25575	COG2207	Transcriptional regulator
I3M_RS25585	COG0076	glutamate decarboxylase activity
I3M_RS25590	COG1858	cytochrome C peroxidase
I3M_RS25600	COG2197	response regulator
I3M_RS25605	COG0583	DNA-binding transcription factor activity
I3M_RS25610	COG1295	ribonuclease BN
I3M_RS25615	COG0477	Major facilitator Superfamily
I3M_RS25620	COG2982	Protein involved in outer membrane biogenesis
I3M_RS25625	COG2200	EAL domain
I3M_RS25640	COG0612	Peptidase, M16
I3M_RS25660	COG2199	diguanylate cyclase activity
I3M_RS25660	COG2200	EAL domain
I3M_RS25665	COG0457	Tetratricopeptide repeat
I3M_RS25665	COG3118	belongs to the thioredoxin family
I3M_RS25670	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I3M_RS25675	COG1215	transferase activity, transferring glycosyl groups
I3M_RS25680	COG1215	transferase activity, transferring glycosyl groups
I3M_RS25705	COG2194	sulfuric ester hydrolase activity
I3M_RS25750	COG0814	amino acid
I3M_RS25755	COG4608	Belongs to the ABC transporter superfamily
I3M_RS25760	COG0444	Belongs to the ABC transporter superfamily
I3M_RS25765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3M_RS25770	COG0601	transmembrane transport
I3M_RS25780	COG0747	negative chemotaxis
I3M_RS25785	COG3738	Protein conserved in bacteria
I3M_RS25790	COG0697	spore germination
I3M_RS25800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3M_RS25805	COG0527	aspartate kinase activity
I3M_RS25805	COG0460	homoserine dehydrogenase
I3M_RS25810	COG0626	cystathionine gamma-synthase activity
I3M_RS25820	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I3M_RS25840	COG3209	COG3209 Rhs family protein
I3M_RS25850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3M_RS25855	COG1609	Transcriptional regulator
I3M_RS25860	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3M_RS25875	COG1575	Belongs to the MenA family. Type 1 subfamily
I3M_RS25890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3M_RS25900	COG1494	fructose-1,6-bisphosphatase
I3M_RS25910	COG0589	response to stress
I3M_RS25915	COG3691	Protein conserved in bacteria
I3M_RS25920	COG3152	Membrane
I3M_RS25940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I3M_RS25955	COG3678	ATP-independent chaperone mediated protein folding
I3M_RS25960	COG0745	RESPONSE REGULATOR receiver
I3M_RS25965	COG2205	protein histidine kinase activity
I3M_RS25970	COG2258	MOSC domain
I3M_RS25985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3M_RS26020	COG1454	alcohol dehydrogenase
I3M_RS26030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS26035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS26035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS26040	COG1363	Peptidase, m42
I3M_RS26045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS26045	COG3711	transcriptional antiterminator
I3M_RS26065	COG3383	formate dehydrogenase (NAD+) activity
I3M_RS26065	COG0243	molybdopterin cofactor binding
I3M_RS26070	COG0243	molybdopterin cofactor binding
I3M_RS26070	COG3383	formate dehydrogenase (NAD+) activity
I3M_RS26075	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS26080	COG2864	formate dehydrogenase
I3M_RS26095	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS26100	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3M_RS26105	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3M_RS26120	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I3M_RS26130	COG0456	acetyltransferase
I3M_RS26145	COG1011	Hydrolase
I3M_RS26150	COG1349	DNA-binding transcription factor activity
I3M_RS26155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS26160	COG2084	Dehydrogenase
I3M_RS26165	COG3684	Belongs to the aldolase LacD family
I3M_RS26170	COG2942	2-epimerase
I3M_RS26175	COG2017	converts alpha-aldose to the beta-anomer
I3M_RS26180	COG1501	Belongs to the glycosyl hydrolase 31 family
I3M_RS26185	COG2211	Major facilitator Superfamily
I3M_RS26190	COG2211	Major facilitator Superfamily
I3M_RS26195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3M_RS26200	COG2271	Major facilitator Superfamily
I3M_RS26205	COG1082	Xylose isomerase domain protein TIM barrel
I3M_RS26210	COG2188	Transcriptional regulator
I3M_RS26215	COG1217	gtp-binding protein TYPA
I3M_RS26225	COG0174	glutamine synthetase
I3M_RS26235	COG3852	Histidine kinase
I3M_RS26240	COG2204	response regulator
I3M_RS26250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3M_RS26265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3M_RS26265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3M_RS26290	COG5339	Protein conserved in bacteria
I3M_RS26295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3M_RS26300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3M_RS26305	COG3084	Protein conserved in bacteria
I3M_RS26310	COG0746	molybdenum cofactor guanylyltransferase activity
I3M_RS26315	COG1763	Mo-molybdopterin cofactor biosynthetic process
I3M_RS26345	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I3M_RS26350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3M_RS26355	COG1739	Uncharacterized protein family UPF0029
I3M_RS26375	COG0543	2 iron, 2 sulfur cluster binding
I3M_RS26380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3M_RS26385	COG0250	Participates in transcription elongation, termination and antitermination
I3M_RS26395	COG0805	protein transport
I3M_RS26400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3M_RS26405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3M_RS26415	COG3165	ubiquinone biosynthetic process from chorismate
I3M_RS26425	COG1322	Protein conserved in bacteria
I3M_RS26430	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I3M_RS26435	COG0412	Dienelactone hydrolase
I3M_RS26445	COG0583	DNA-binding transcription factor activity
I3M_RS26450	COG0697	spore germination
I3M_RS26455	COG0561	phosphatase activity
I3M_RS26460	COG2267	carboxylic ester hydrolase activity
I3M_RS26465	COG1280	lysine exporter protein (LysE YggA)
I3M_RS26470	COG1280	lysine exporter protein (LysE YggA)
I3M_RS26475	COG0514	ATP-dependent DNA helicase (RecQ)
I3M_RS26480	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I3M_RS26485	COG2050	protein possibly involved in aromatic compounds catabolism
I3M_RS26490	COG2962	Rard protein
I3M_RS26520	COG0598	Magnesium transport protein CorA
I3M_RS26525	COG3698	Phosphodiester glycosidase
I3M_RS26530	COG0210	DNA helicase
I3M_RS26535	COG1011	Hydrolase
I3M_RS26545	COG3159	Protein conserved in bacteria
I3M_RS26555	COG5567	small periplasmic lipoprotein
I3M_RS26580	COG3072	Adenylate cyclase
I3M_RS26595	COG1587	Uroporphyrinogen-III synthase
I3M_RS26600	COG2959	enzyme of heme biosynthesis
I3M_RS26605	COG3071	HemY protein
I3M_RS26610	COG0641	radical SAM
I3M_RS26635	COG1113	amino acid transport
I3M_RS26655	COG2244	polysaccharide biosynthetic process
I3M_RS26660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3M_RS26665	COG0456	acetyltransferase
I3M_RS26670	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3M_RS26675	COG1088	dTDP-glucose 4,6-dehydratase activity
I3M_RS26680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I3M_RS26685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3M_RS26690	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3M_RS26695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3M_RS26705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I3M_RS26715	COG3118	belongs to the thioredoxin family
I3M_RS26735	COG0210	DNA helicase
I3M_RS26740	COG3692	DNA binding
I3M_RS26745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3M_RS26755	COG0583	DNA-binding transcription factor activity
I3M_RS26760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3M_RS26770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3M_RS26775	COG3978	acetolactate synthase activity
I3M_RS26800	COG0606	chelatase, subunit chli
I3M_RS26805	COG3085	chromosome segregation
I3M_RS26845	COG2186	Transcriptional regulator
I3M_RS26850	COG0477	Major facilitator Superfamily
I3M_RS26855	COG1609	Transcriptional regulator
I3M_RS26860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3M_RS26865	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS26870	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS26875	COG1129	ABC transporter
I3M_RS26905	COG1522	sequence-specific DNA binding
I3M_RS26910	COG0716	FMN binding
I3M_RS26925	COG3312	ion transport
I3M_RS26980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3M_RS26995	COG3188	usher protein
I3M_RS27005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3M_RS27010	COG0573	inorganic phosphate transmembrane transporter activity
I3M_RS27015	COG0581	inorganic phosphate transmembrane transporter activity
I3M_RS27020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3M_RS27025	COG0704	Plays a role in the regulation of phosphate uptake
I3M_RS27030	COG3711	transcriptional antiterminator
I3M_RS27035	COG1263	PTS System
I3M_RS27035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3M_RS27035	COG2190	(PTS) system
I3M_RS27040	COG2723	6-phospho-beta-galactosidase activity
I3M_RS27050	COG2382	esterase
I3M_RS27055	COG0363	glucosamine-6-phosphate deaminase activity
I3M_RS27060	COG3196	Protein conserved in bacteria
I3M_RS27070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3M_RS27075	COG2252	PERMEase
I3M_RS27080	COG0431	NADPH-dependent FMN reductase
I3M_RS27085	COG2091	lysine biosynthetic process via aminoadipic acid
I3M_RS27100	COG0814	amino acid
I3M_RS27150	COG0592	DNA-directed DNA polymerase activity
I3M_RS27160	COG0187	DNA topoisomerase II activity
I3M_RS27165	COG3753	Protein conserved in bacteria
I3M_RS27170	COG0561	phosphatase activity
I3M_RS27180	COG2186	Transcriptional regulator
I3M_RS27185	COG3734	2-keto-3-deoxy-galactonokinase
I3M_RS27190	COG0800	Aldolase
I3M_RS27200	COG2271	Major facilitator Superfamily
I3M_RS27210	COG0823	Involved in the tonB-independent uptake of proteins
I3M_RS27215	COG5645	(Lipo)protein
I3M_RS27235	COG2188	Transcriptional regulator
I3M_RS27250	COG2207	Transcriptional regulator
I3M_RS27255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3M_RS27260	COG3119	arylsulfatase activity
I3M_RS27270	COG2149	membrane
I3M_RS27280	COG0641	radical SAM
I3M_RS27285	COG2814	Major facilitator Superfamily
I3M_RS27320	COG0028	Belongs to the TPP enzyme family
I3M_RS27325	COG0440	acetolactate synthase activity
I3M_RS27330	COG2197	response regulator
I3M_RS27335	COG3851	Histidine kinase
I3M_RS27340	COG2271	Major facilitator Superfamily
I3M_RS27345	COG2271	Major facilitator Superfamily
I3M_RS27355	COG2252	PERMEase
I3M_RS27385	COG1464	Belongs to the NlpA lipoprotein family
I3M_RS27390	COG0697	spore germination
I3M_RS27395	COG2814	Major facilitator Superfamily
I3M_RS27435	COG3436	PFAM IS66 Orf2 family protein
I3M_RS27440	COG4372	Transposase
I3M_RS27495	COG0582	viral genome integration into host DNA
I3M_RS27505	COG2211	Major facilitator Superfamily
I3M_RS27510	COG1501	Belongs to the glycosyl hydrolase 31 family
I3M_RS27515	COG2982	Protein involved in outer membrane biogenesis
I3M_RS27520	COG2233	PERMEase
I3M_RS27525	COG0786	glutamate:sodium symporter activity
I3M_RS27535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3M_RS27540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3M_RS27545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3M_RS27555	COG0194	GDP metabolic process
I3M_RS27565	COG2860	membrane
I3M_RS27570	COG3645	SOS response
I3M_RS27575	COG1561	YicC-like family, N-terminal region
I3M_RS27605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3M_RS27635	COG1519	Transferase
I3M_RS27640	COG0859	PFAM glycosyl transferase family 9
I3M_RS27645	COG0438	transferase activity, transferring glycosyl groups
I3M_RS27650	COG0515	serine threonine protein kinase
I3M_RS27660	COG3642	lipopolysaccharide core region biosynthetic process
I3M_RS27680	COG0859	PFAM glycosyl transferase family 9
I3M_RS27685	COG0859	PFAM glycosyl transferase family 9
I3M_RS27700	COG0156	8-amino-7-oxononanoate synthase activity
I3M_RS27710	COG1216	Glycosyl transferase, family 2
I3M_RS27715	COG2861	carbohydrate metabolic process
I3M_RS27720	COG4942	peptidase
I3M_RS27735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3M_RS27740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3M_RS27755	COG1045	serine acetyltransferase
I3M_RS27760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3M_RS27770	COG2186	Transcriptional regulator
I3M_RS27775	COG1620	l-lactate permease
I3M_RS27785	COG5295	Hep Hag repeat protein
I3M_RS27810	COG3722	fumarate hydratase activity
I3M_RS27820	COG2213	PTS system mannitol-specific
I3M_RS27820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3M_RS27850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3M_RS27860	COG1413	lyase activity
I3M_RS27865	COG3209	COG3209 Rhs family protein
I3M_RS27870	COG0625	glutathione transferase activity
I3M_RS27880	COG3276	selenocysteine insertion sequence binding
I3M_RS27885	COG1454	alcohol dehydrogenase
I3M_RS27890	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS27905	COG1566	PFAM secretion protein HlyD family protein
I3M_RS27910	COG0583	DNA-binding transcription factor activity
I3M_RS27915	COG3713	MltA-interacting MipA family protein
I3M_RS27925	COG0235	Class ii aldolase
I3M_RS27930	COG3623	hexulose-6-phosphate isomerase
I3M_RS27935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3M_RS27940	COG1070	Carbohydrate kinase
I3M_RS27945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3M_RS27950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I3M_RS27955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3M_RS27960	COG2731	YhcH YjgK YiaL family protein
I3M_RS27970	COG1414	Transcriptional regulator
I3M_RS27975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3M_RS27980	COG3977	Valine--pyruvate aminotransferase
I3M_RS27985	COG0366	Alpha amylase catalytic
I3M_RS27990	COG2992	FlgJ-related protein
I3M_RS27995	COG1609	Transcriptional regulator
I3M_RS27995	COG2207	Transcriptional regulator
I3M_RS28000	COG4214	carbohydrate transport
I3M_RS28005	COG1129	ABC transporter
I3M_RS28010	COG4213	ABC transporter substrate-binding protein
I3M_RS28020	COG1070	Carbohydrate kinase
I3M_RS28025	COG4682	membrane
I3M_RS28030	COG4682	membrane
I3M_RS28035	COG3274	enterobacterial common antigen metabolic process
I3M_RS28060	COG1278	Cold shock
I3M_RS28065	COG2944	sequence-specific DNA binding
I3M_RS28080	COG2885	chlorophyll binding
I3M_RS28085	COG0243	molybdopterin cofactor binding
I3M_RS28090	COG0456	acetyltransferase
I3M_RS28095	COG2818	Glycosylase
I3M_RS28100	COG5571	outer membrane autotransporter
I3M_RS28110	COG2223	nitrite transmembrane transporter activity
I3M_RS28140	COG2194	sulfuric ester hydrolase activity
I3M_RS28160	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS28170	COG0371	Dehydrogenase
I3M_RS28175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3M_RS28185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS28190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS28195	COG1882	Formate acetyltransferase
I3M_RS28200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3M_RS28205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3M_RS28210	COG2207	Transcriptional regulator
I3M_RS28215	COG2194	sulfuric ester hydrolase activity
I3M_RS28230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3M_RS28245	COG0583	DNA-binding transcription factor activity
I3M_RS28310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I3M_RS28310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I3M_RS28355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3M_RS28360	COG0250	Participates in transcription elongation, termination and antitermination
I3M_RS28405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3M_RS28415	COG2104	thiamine diphosphate biosynthetic process
I3M_RS28420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3M_RS28455	COG3068	Protein conserved in bacteria
I3M_RS28470	COG3678	ATP-independent chaperone mediated protein folding
I3M_RS28480	COG4191	Histidine kinase
I3M_RS28485	COG2204	response regulator
I3M_RS28490	COG0151	Belongs to the GarS family
I3M_RS28525	COG0456	acetyltransferase
I3M_RS28535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3M_RS28540	COG2224	Isocitrate lyase
I3M_RS28560	COG1414	Transcriptional regulator
I3M_RS28565	COG0646	methionine synthase
I3M_RS28565	COG1410	methionine synthase
I3M_RS28570	COG1283	sodium-dependent phosphate transmembrane transporter activity
I3M_RS28630	COG3541	Predicted nucleotidyltransferase
I3M_RS28635	COG0542	response to heat
I3M_RS28640	COG0527	aspartate kinase activity
I3M_RS28675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3M_RS28690	COG0477	Major facilitator Superfamily
I3M_RS28690	COG2814	Major facilitator Superfamily
I3M_RS28695	COG3833	ABC-type maltose transport systems, permease component
I3M_RS28700	COG1175	transmembrane transport
I3M_RS28705	COG2182	Extracellular solute-binding protein
I3M_RS28715	COG3842	ATPase activity
I3M_RS28755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3M_RS28765	COG0534	Mate efflux family protein
I3M_RS28770	COG3237	CsbD-like
I3M_RS28775	COG0735	belongs to the Fur family
I3M_RS28790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3M_RS28800	COG0604	alcohol dehydrogenase
I3M_RS28805	COG0305	Participates in initiation and elongation during chromosome replication
I3M_RS28810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3M_RS28815	COG1448	Aminotransferase
I3M_RS28825	COG3700	Belongs to the class B bacterial acid phosphatase family
I3M_RS28830	COG0432	Pfam Uncharacterised protein family UPF0047
I3M_RS28835	COG2315	Protein conserved in bacteria
I3M_RS28840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3M_RS28850	COG0629	single-stranded DNA binding
I3M_RS28865	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I3M_RS28870	COG2207	Transcriptional regulator
I3M_RS28875	COG0789	Transcriptional regulator
I3M_RS28895	COG2252	PERMEase
I3M_RS28900	COG0025	NhaP-type Na H and K H
I3M_RS28915	COG3162	membrane
I3M_RS28920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3M_RS28935	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I3M_RS28940	COG0437	4 iron, 4 sulfur cluster binding
I3M_RS28945	COG3301	Polysulphide reductase, NrfD
I3M_RS28950	COG1138	Cytochrome C-type biogenesis protein
I3M_RS28955	COG3088	subunit of a heme lyase
I3M_RS28960	COG4235	cytochrome complex assembly
I3M_RS28970	COG1301	dicarboxylic acid transport
I3M_RS28975	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3M_RS28990	COG1289	transmembrane transporter activity
I3M_RS28995	COG1566	PFAM secretion protein HlyD family protein
I3M_RS29005	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3M_RS29010	COG0698	ribose 5-phosphate isomerase
I3M_RS29020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3M_RS29025	COG0456	acetyltransferase
I3M_RS29030	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I3M_RS29035	COG3454	Phosphonate metabolism
I3M_RS29040	COG4778	phosphonate C-P lyase system protein PhnL
I3M_RS29045	COG4107	phosphonate C-P lyase system protein PhnK
I3M_RS29050	COG3627	carbon phosphorus lyase activity
I3M_RS29055	COG3626	phosphonate metabolism
I3M_RS29060	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I3M_RS29065	COG3624	Phosphonate C-P lyase system protein PhnG
I3M_RS29070	COG2188	Transcriptional regulator
I3M_RS29075	COG3639	organic phosphonate transmembrane transporter activity
I3M_RS29080	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I3M_RS29090	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I3M_RS29095	COG2824	Alkylphosphonate utilization operon protein PhnA
I3M_RS29105	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I3M_RS29115	COG0477	Major facilitator Superfamily
I3M_RS29125	COG0642	Histidine kinase
I3M_RS29130	COG0745	RESPONSE REGULATOR receiver
I3M_RS29135	COG2194	sulfuric ester hydrolase activity
I3M_RS29140	COG0531	amino acid
I3M_RS29145	COG2207	Transcriptional regulator
I3M_RS29150	COG1982	Orn Lys Arg decarboxylase major
I3M_RS29155	COG2169	Transcriptional regulator
I3M_RS29165	COG1486	melibiose metabolic process
I3M_RS29170	COG2211	Major facilitator Superfamily
I3M_RS29180	COG3647	Membrane
I3M_RS29185	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3M_RS29185	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3M_RS29190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3M_RS29200	COG4565	transcriptional regulatory protein
I3M_RS29205	COG3290	protein histidine kinase activity
I3M_RS29210	COG3592	Divergent 4Fe-4S mono-cluster
I3M_RS29215	COG2388	GCN5-related N-acetyl-transferase
I3M_RS29235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3M_RS29240	COG3104	oligopeptide transport
I3M_RS29245	COG1982	Orn Lys Arg decarboxylase major
I3M_RS29250	COG0531	amino acid
I3M_RS29260	COG3710	Transcriptional regulator
I3M_RS29545	COG4372	Transposase
I3M_RS29550	COG0582	viral genome integration into host DNA
I3M_RS29560	COG1309	transcriptional regulator
I3M_RS29575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3M_RS29580	COG1027	Aspartate ammonia-lyase
I3M_RS29585	COG3030	protein affecting phage T7 exclusion by the F plasmid
I3M_RS29590	COG0531	amino acid
I3M_RS29615	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS29625	COG1509	lysine 2,3-aminomutase activity
I3M_RS29635	COG5510	response to toxic substance
I3M_RS29640	COG5510	response to toxic substance
I3M_RS29645	COG2076	Multidrug Resistance protein
I3M_RS29650	COG3040	lipid binding
I3M_RS29655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3M_RS29670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3M_RS29675	COG1053	succinate dehydrogenase
I3M_RS29685	COG0531	amino acid
I3M_RS29700	COG1511	domain protein
I3M_RS29700	COG3264	Mechanosensitive ion channel
I3M_RS29745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I3M_RS29745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I3M_RS29750	COG0802	atpase or kinase
I3M_RS29755	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3M_RS29775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3M_RS29780	COG0330	HflC and HflK could
I3M_RS29785	COG0330	HflC and HflK could
I3M_RS29790	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I3M_RS29805	COG0557	exoribonuclease II activity
I3M_RS29810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3M_RS29820	COG3789	protein conserved in bacteria
I3M_RS29825	COG1842	Phage shock protein A
I3M_RS29835	COG3766	membrane
I3M_RS29840	COG5463	Belongs to the UPF0441 family
I3M_RS29845	COG0754	glutathionylspermidine amidase activity
I3M_RS29850	COG1960	acyl-CoA dehydrogenase activity
I3M_RS29860	COG3650	response to hydrogen peroxide
I3M_RS29865	COG1073	alpha beta
I3M_RS29880	COG3037	sugar-specific permease SgaT UlaA
I3M_RS29925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3M_RS29950	COG0675	Transposase, IS605 OrfB family
I3M_RS29960	COG3061	Opacity-associated protein A
I3M_RS29970	COG0545	Peptidyl-prolyl cis-trans isomerase
I3M_RS29975	COG1113	amino acid transport
I3M_RS29995	COG0697	spore germination
I3M_RS30000	COG0702	epimerase
I3M_RS30005	COG1733	regulation of RNA biosynthetic process
I3M_RS30010	COG0737	Belongs to the 5'-nucleotidase family
I3M_RS30015	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3M_RS30020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3M_RS30030	COG1253	flavin adenine dinucleotide binding
I3M_RS30045	COG0729	surface antigen
I3M_RS30050	COG2911	Protein conserved in bacteria
I3M_RS30055	COG2105	PFAM AIG2 family protein
I3M_RS30060	COG2336	PFAM SpoVT AbrB
I3M_RS30065	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3M_RS30070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3M_RS30075	COG1879	ABC-type sugar transport system periplasmic component
I3M_RS30080	COG1129	ABC transporter
I3M_RS30085	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS30090	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3M_RS30100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3M_RS30110	COG0312	modulator of DNA gyrase
I3M_RS30120	COG4372	Transposase
I3M_RS30125	COG3436	PFAM IS66 Orf2 family protein
I3M_RS30145	COG0602	queuosine metabolic process
I3M_RS30150	COG1328	CTP reductase activity
I3M_RS30155	COG0366	Alpha amylase catalytic
I3M_RS30165	COG1609	Transcriptional regulator
I3M_RS30175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3M_RS30180	COG3547	Transposase (IS116 IS110 IS902 family)
I3M_RS30190	COG0251	oxidation-reduction process
I3M_RS30215	COG0251	oxidation-reduction process
I3M_RS30220	COG1028	Short-chain dehydrogenase reductase Sdr
I3M_RS30225	COG1309	transcriptional regulator
I3M_RS30230	COG2731	YhcH YjgK YiaL family protein
I3M_RS30250	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I3M_RS30255	COG0456	acetyltransferase
I3M_RS30270	COG2927	DNA polymerase III (CHI subunit)
I3M_RS30280	COG0795	lipopolysaccharide-transporting ATPase activity
I3M_RS30285	COG0795	lipopolysaccharide-transporting ATPase activity
I3M_RS30290	COG0433	COG0433 Predicted ATPase
I3M_RS30295	COG1064	alcohol dehydrogenase
I3M_RS30305	COG0582	viral genome integration into host DNA
I3M_RS30330	COG3436	PFAM IS66 Orf2 family protein
I3M_RS30335	COG4372	Transposase
I3M_RS30405	COG2085	NADP oxidoreductase coenzyme F420-dependent
I3M_RS30410	COG1120	ATPase activity
I3M_RS30415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3M_RS30420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3M_RS30425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3M_RS30430	COG4772	TonB-dependent receptor
I3M_RS30435	COG3712	iron ion homeostasis
I3M_RS30440	COG1595	DNA-templated transcription, initiation
I3M_RS30485	COG4372	Transposase
I3M_RS30490	COG3436	PFAM IS66 Orf2 family protein
I3M_RS30550	COG2003	Belongs to the UPF0758 family
I3M_RS30610	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I3M_RS30615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3M_RS30635	COG0582	viral genome integration into host DNA
I3M_RS30640	COG4974	Belongs to the 'phage' integrase family
I3M_RS30655	COG3539	Fimbrial protein
I3M_RS30660	COG3121	Chaperone
I3M_RS30665	COG3188	usher protein
I3M_RS30670	COG3539	Fimbrial protein
I3M_RS30675	COG3539	Fimbrial protein
I3M_RS30680	COG3539	Fimbrial protein
I3M_RS30700	COG0246	Mannitol dehydrogenase
I3M_RS30710	COG2186	Transcriptional regulator
I3M_RS30735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3M_RS30740	COG0700	Nucleoside recognition
I3M_RS30745	COG3366	ferrous iron transmembrane transporter activity
I3M_RS30760	COG0477	Major facilitator Superfamily
I3M_RS30775	COG1924	4 iron, 4 sulfur cluster binding
I3M_RS30780	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I3M_RS30785	COG2733	membrane
I3M_RS30790	COG2814	Major facilitator Superfamily
I3M_RS30800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3M_RS30805	COG5457	Domain of unknown function (DUF1127)
I3M_RS30820	COG0732	type I restriction modification DNA specificity domain
I3M_RS30845	COG0523	cobalamin synthesis protein
I3M_RS30850	COG2879	small protein
I3M_RS30855	COG1966	Carbon starvation protein
I3M_RS30865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3M_RS30870	COG2368	4-hydroxyphenylacetate
I3M_RS30890	COG3971	2-oxopent-4-enoate hydratase activity
I3M_RS30900	COG3384	dioxygenase
I3M_RS30905	COG1012	belongs to the aldehyde dehydrogenase family
I3M_RS30910	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3M_RS30915	COG1846	Transcriptional regulator
I3M_RS30920	COG0840	transmembrane signaling receptor activity
I3M_RS30925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I3M_RS30935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3M_RS30940	COG0025	NhaP-type Na H and K H
I3M_RS30945	COG1802	Transcriptional regulator
I3M_RS30950	COG1063	alcohol dehydrogenase
I3M_RS30965	COG1484	DNA-dependent DNA replication
I3M_RS30980	COG2966	Psort location CytoplasmicMembrane, score
I3M_RS30985	COG2197	response regulator
I3M_RS30990	COG2197	response regulator
I3M_RS30995	COG4114	ferric iron reductase
I3M_RS31025	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I3M_RS31030	COG0456	acetyltransferase
I3M_RS31035	COG1011	Hydrolase
I3M_RS31045	COG2823	Periplasmic or secreted lipoprotein
I3M_RS31055	COG4667	esterase of the alpha-beta hydrolase superfamily
I3M_RS31060	COG0084	hydrolase, TatD family'
I3M_RS31075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3M_RS31080	COG1328	CTP reductase activity
I3M_RS31115	COG3726	membrane protein affecting hemolysin expression
I3M_RS31120	COG0560	Phosphoserine phosphatase
I3M_RS31125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3M_RS31130	COG1056	cytidyltransferase-related domain
I3M_RS31130	COG3172	ATPase kinase involved in NAD metabolism
I3M_RS31135	COG0488	(ABC) transporter
I3M_RS31145	COG0741	lytic transglycosylase activity
I3M_RS31165	COG2207	Transcriptional regulator
I3M_RS31165	COG3708	Transcriptional regulator
I3M_RS31170	COG3045	CreA protein
I3M_RS31175	COG0745	RESPONSE REGULATOR receiver
I3M_RS31180	COG2205	protein histidine kinase activity
I3M_RS31185	COG4452	Inner membrane protein CreD
I3M_RS31190	COG0745	RESPONSE REGULATOR receiver
I3M_RS31200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA