locus-tag	class	description
I3W_RS00015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3W_RS00030	COG0741	lytic transglycosylase activity
I3W_RS00085	COG2805	Type II/IV secretion system protein
I3W_RS00200	COG2194	sulfuric ester hydrolase activity
I3W_RS00370	COG1475	DNA binding
I3W_RS00545	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3W_RS00550	COG2268	Band 7 protein
I3W_RS00640	COG4771	TonB-dependent receptor
I3W_RS00650	COG4372	Transposase
I3W_RS00655	COG3436	PFAM IS66 Orf2 family protein
I3W_RS00735	COG2801	Transposase and inactivated derivatives
I3W_RS00745	COG1556	Lactate utilization protein
I3W_RS00750	COG1139	Iron-sulfur cluster binding protein
I3W_RS00755	COG0247	lactate metabolic process
I3W_RS00760	COG1620	l-lactate permease
I3W_RS00785	COG3436	PFAM IS66 Orf2 family protein
I3W_RS00790	COG4372	Transposase
I3W_RS00910	COG4372	Transposase
I3W_RS00915	COG3436	PFAM IS66 Orf2 family protein
I3W_RS01180	COG5295	Hep Hag repeat protein
I3W_RS01220	COG4372	Transposase
I3W_RS01225	COG3436	PFAM IS66 Orf2 family protein
I3W_RS01245	COG0460	homoserine dehydrogenase
I3W_RS01245	COG0527	aspartate kinase activity
I3W_RS01255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3W_RS01270	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS01280	COG1115	amino acid carrier protein
I3W_RS01290	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3W_RS01295	COG1584	GPR1 FUN34 yaaH family protein
I3W_RS01300	COG4735	regulation of single-species biofilm formation
I3W_RS01330	COG0583	DNA-binding transcription factor activity
I3W_RS01360	COG0196	riboflavin kinase activity
I3W_RS01375	COG1047	Peptidyl-prolyl cis-trans
I3W_RS01400	COG0505	Belongs to the CarA family
I3W_RS01405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3W_RS01460	COG0644	oxidoreductase
I3W_RS01465	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3W_RS01470	COG2271	Major facilitator Superfamily
I3W_RS01485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I3W_RS01525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3W_RS01530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3W_RS01535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I3W_RS01540	COG0564	pseudouridine synthase activity
I3W_RS01550	COG0417	DNA replication proofreading
I3W_RS01555	COG0235	Class ii aldolase
I3W_RS01575	COG4977	sequence-specific DNA binding
I3W_RS01580	COG0586	Pfam SNARE associated Golgi protein
I3W_RS01590	COG1178	ABC-type Fe3 transport system permease component
I3W_RS01595	COG4143	(ABC) transporter
I3W_RS01610	COG2814	Major facilitator Superfamily
I3W_RS01625	COG0473	3-isopropylmalate dehydrogenase activity
I3W_RS01640	COG0583	DNA-binding transcription factor activity
I3W_RS01645	COG0028	Belongs to the TPP enzyme family
I3W_RS01650	COG0440	acetolactate synthase activity
I3W_RS01660	COG1609	Transcriptional regulator
I3W_RS01685	COG3116	cell division
I3W_RS01690	COG0768	penicillin binding
I3W_RS01695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3W_RS01700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3W_RS01715	COG0772	Belongs to the SEDS family
I3W_RS01730	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3W_RS01735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3W_RS01740	COG0849	cell division
I3W_RS01745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3W_RS01765	COG0494	nUDIX hydrolase
I3W_RS01780	COG0237	dephospho-CoA kinase activity
I3W_RS01790	COG1459	type II secretion system
I3W_RS01795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3W_RS01800	COG4969	Belongs to the N-Me-Phe pilin family
I3W_RS01810	COG0157	Belongs to the NadC ModD family
I3W_RS01815	COG3023	N-Acetylmuramoyl-L-alanine amidase
I3W_RS01820	COG3725	Membrane protein required for beta-lactamase induction
I3W_RS01825	COG1113	amino acid transport
I3W_RS01830	COG2186	Transcriptional regulator
I3W_RS01840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3W_RS01845	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3W_RS01850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3W_RS01855	COG3064	Membrane
I3W_RS01865	COG1049	propionate catabolic process, 2-methylcitrate cycle
I3W_RS01890	COG2132	Multicopper oxidase
I3W_RS01895	COG4993	Dehydrogenase
I3W_RS01900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3W_RS01905	COG0288	reversible hydration of carbon dioxide
I3W_RS01910	COG1131	(ABC) transporter
I3W_RS01915	COG0842	Transport permease protein
I3W_RS01920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS01925	COG0726	polysaccharide deacetylase
I3W_RS01945	COG5464	transposase or invertase
I3W_RS01960	COG3539	Fimbrial protein
I3W_RS01965	COG3539	Fimbrial protein
I3W_RS01970	COG3539	Fimbrial protein
I3W_RS01975	COG3539	Fimbrial protein
I3W_RS01980	COG3188	usher protein
I3W_RS01985	COG3121	Chaperone
I3W_RS01990	COG3539	Fimbrial protein
I3W_RS01995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I3W_RS02000	COG0617	tRNA 3'-terminal CCA addition
I3W_RS02010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3W_RS02020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I3W_RS02025	COG1643	Atp-dependent helicase
I3W_RS02035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3W_RS02040	COG4774	siderophore transport
I3W_RS02045	COG1120	ATPase activity
I3W_RS02050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3W_RS02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3W_RS02075	COG2860	membrane
I3W_RS02080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3W_RS02100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3W_RS02105	COG3835	regulator
I3W_RS02125	COG0024	Methionine aminopeptidase
I3W_RS02160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I3W_RS02165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3W_RS02170	COG0575	Belongs to the CDS family
I3W_RS02175	COG0750	zinc metalloprotease
I3W_RS02185	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I3W_RS02190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3W_RS02215	COG0587	DNA-directed DNA polymerase activity
I3W_RS02225	COG1982	Orn Lys Arg decarboxylase major
I3W_RS02230	COG0346	lactoylglutathione lyase activity
I3W_RS02240	COG4568	rho-dependent transcription termination
I3W_RS02250	COG4681	YaeQ
I3W_RS02255	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3W_RS02260	COG3015	lipoprotein NlpE involved in copper resistance
I3W_RS02270	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS02275	COG0791	NLP P60 protein
I3W_RS02285	COG1720	tRNA m6t6A37 methyltransferase activity
I3W_RS02295	COG1464	Belongs to the NlpA lipoprotein family
I3W_RS02300	COG2011	ABC-type metal ion transport system permease component
I3W_RS02305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3W_RS02310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3W_RS02345	COG0656	L-ascorbic acid biosynthetic process
I3W_RS02350	COG0583	DNA-binding transcription factor activity
I3W_RS02360	COG2226	methyltransferase
I3W_RS02365	COG1388	LysM domain
I3W_RS02365	COG0741	lytic transglycosylase activity
I3W_RS02375	COG2226	methyltransferase
I3W_RS02385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3W_RS02410	COG4104	PAAR repeat-containing protein
I3W_RS02415	COG3157	Type VI secretion system effector, Hcp
I3W_RS02510	COG3209	COG3209 Rhs family protein
I3W_RS02530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3W_RS02540	COG1960	acyl-CoA dehydrogenase activity
I3W_RS02550	COG0121	glutamine amidotransferase
I3W_RS02555	COG3034	peptidoglycan biosynthetic process
I3W_RS02560	COG3041	Addiction module toxin RelE StbE family
I3W_RS02565	COG3077	Addiction module antitoxin, RelB DinJ family
I3W_RS02570	COG0791	NLP P60 protein
I3W_RS02600	COG0454	-acetyltransferase
I3W_RS02610	COG1690	Belongs to the RtcB family
I3W_RS02615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3W_RS02620	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3W_RS02640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3W_RS02660	COG0583	DNA-binding transcription factor activity
I3W_RS02665	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3W_RS02670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3W_RS02675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3W_RS02680	COG2080	2 iron, 2 sulfur cluster binding
I3W_RS02690	COG3477	response to acidic pH
I3W_RS02700	COG0727	PFAM Uncharacterised protein family (UPF0153)
I3W_RS02705	COG3121	Chaperone
I3W_RS02715	COG3188	usher protein
I3W_RS02770	COG1388	LysM domain
I3W_RS02775	COG3708	Transcriptional regulator
I3W_RS02775	COG2207	Transcriptional regulator
I3W_RS02780	COG3059	membrane
I3W_RS02790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3W_RS02795	COG2207	Transcriptional regulator
I3W_RS02800	COG0247	lactate metabolic process
I3W_RS02805	COG1139	Iron-sulfur cluster binding protein
I3W_RS02810	COG1556	Lactate utilization protein
I3W_RS02850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3W_RS02860	COG2200	EAL domain
I3W_RS02860	COG2771	luxR family
I3W_RS02865	COG0583	DNA-binding transcription factor activity
I3W_RS02880	COG0666	response to abiotic stimulus
I3W_RS02890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3W_RS02895	COG1304	FMN binding
I3W_RS02900	COG0549	Belongs to the carbamate kinase family
I3W_RS02905	COG0402	S-adenosylhomocysteine deaminase activity
I3W_RS02915	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS02920	COG1129	ABC transporter
I3W_RS02925	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS02935	COG1064	alcohol dehydrogenase
I3W_RS02950	COG1280	lysine exporter protein (LysE YggA)
I3W_RS02965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3W_RS02970	COG0372	Belongs to the citrate synthase family
I3W_RS02975	COG2079	MmgE PrpD family protein
I3W_RS02980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3W_RS02985	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I3W_RS02990	COG0402	S-adenosylhomocysteine deaminase activity
I3W_RS02995	COG0583	DNA-binding transcription factor activity
I3W_RS03000	COG0288	reversible hydration of carbon dioxide
I3W_RS03010	COG2807	transmembrane transport
I3W_RS03015	COG0110	maltose O-acetyltransferase activity
I3W_RS03020	COG2223	nitrite transmembrane transporter activity
I3W_RS03035	COG1609	Transcriptional regulator
I3W_RS03040	COG1414	Transcriptional regulator
I3W_RS03080	COG3122	Protein conserved in bacteria
I3W_RS03090	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS03125	COG1215	transferase activity, transferring glycosyl groups
I3W_RS03130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3W_RS03140	COG4521	taurine ABC transporter
I3W_RS03150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3W_RS03155	COG2175	clavaminate synthase activity
I3W_RS03160	COG0113	porphobilinogen synthase activity
I3W_RS03170	COG3468	outer membrane autotransporter barrel domain protein
I3W_RS03175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3W_RS03180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3W_RS03190	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I3W_RS03215	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3W_RS03230	COG1785	Belongs to the alkaline phosphatase family
I3W_RS03240	COG3706	GGDEF domain
I3W_RS03245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3W_RS03270	COG4126	flavin adenine dinucleotide binding
I3W_RS03295	COG1940	carbohydrate kinase activity
I3W_RS03300	COG2814	Major facilitator Superfamily
I3W_RS03305	COG0419	ATPase involved in DNA repair
I3W_RS03310	COG0420	3'-5' exonuclease activity
I3W_RS03315	COG0745	RESPONSE REGULATOR receiver
I3W_RS03320	COG5002	protein histidine kinase activity
I3W_RS03325	COG1114	Component of the transport system for branched-chain amino acids
I3W_RS03330	COG1113	amino acid transport
I3W_RS03335	COG0366	Alpha amylase catalytic
I3W_RS03355	COG1862	Preprotein translocase
I3W_RS03360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3W_RS03365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3W_RS03370	COG1403	HNH endonuclease
I3W_RS03375	COG3248	Nucleoside-binding outer membrane protein
I3W_RS03380	COG4238	major outer membrane lipoprotein
I3W_RS03390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3W_RS03390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3W_RS03405	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I3W_RS03410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I3W_RS03415	COG0667	Aldo Keto reductase
I3W_RS03425	COG0142	geranyltranstransferase activity
I3W_RS03440	COG0693	protein deglycase activity
I3W_RS03445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3W_RS03455	COG2814	Major facilitator Superfamily
I3W_RS03480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I3W_RS03485	COG1845	cytochrome c oxidase, subunit III
I3W_RS03490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3W_RS03495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3W_RS03500	COG2223	nitrite transmembrane transporter activity
I3W_RS03505	COG3056	Lipoprotein
I3W_RS03515	COG0271	Belongs to the BolA IbaG family
I3W_RS03540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3W_RS03545	COG0776	regulation of translation
I3W_RS03550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3W_RS03555	COG1555	photosystem II stabilization
I3W_RS03560	COG0824	Thioesterase
I3W_RS03570	COG4533	DNA binding
I3W_RS03580	COG1522	sequence-specific DNA binding
I3W_RS03585	COG1132	(ABC) transporter
I3W_RS03590	COG1132	(ABC) transporter
I3W_RS03595	COG0347	Belongs to the P(II) protein family
I3W_RS03600	COG0004	ammonium transporteR
I3W_RS03605	COG1946	Acyl-CoA thioesterase
I3W_RS03610	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I3W_RS03615	COG3695	enzyme binding
I3W_RS03625	COG5507	3-demethylubiquinone-9 3-methyltransferase
I3W_RS03630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I3W_RS03640	COG0110	maltose O-acetyltransferase activity
I3W_RS03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3W_RS03660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS03665	COG1309	transcriptional regulator
I3W_RS03675	COG3264	Mechanosensitive ion channel
I3W_RS03675	COG1196	nuclear chromosome segregation
I3W_RS03685	COG3923	Primosomal replication protein n
I3W_RS03690	COG2832	Protein of unknown function (DUF454)
I3W_RS03705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3W_RS03745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS03750	COG4651	solute:proton antiporter activity
I3W_RS03750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3W_RS03755	COG2223	nitrite transmembrane transporter activity
I3W_RS03765	COG0737	Belongs to the 5'-nucleotidase family
I3W_RS03770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3W_RS03780	COG3735	TraB family
I3W_RS03790	COG3093	addiction module antidote protein HigA
I3W_RS03795	COG2217	Heavy metal translocating P-type atpase
I3W_RS03800	COG2066	Belongs to the glutaminase family
I3W_RS03805	COG0531	amino acid
I3W_RS03810	COG0789	Transcriptional regulator
I3W_RS03815	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3W_RS03820	COG0330	HflC and HflK could
I3W_RS03825	COG4619	ABC transporter
I3W_RS03830	COG0390	transport system, permease component
I3W_RS03835	COG3118	belongs to the thioredoxin family
I3W_RS03840	COG0300	oxidoreductase activity
I3W_RS03845	COG2755	lipolytic protein G-D-S-L family
I3W_RS03850	COG4181	ATPase activity
I3W_RS03855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I3W_RS03860	COG3209	COG3209 Rhs family protein
I3W_RS03890	COG0583	DNA-binding transcription factor activity
I3W_RS03900	COG1414	Transcriptional regulator
I3W_RS03905	COG3960	tartronate-semialdehyde synthase activity
I3W_RS03910	COG3622	Belongs to the hyi family
I3W_RS03915	COG2084	Dehydrogenase
I3W_RS03920	COG1953	Uracil, thiamine, allantoin
I3W_RS03930	COG2233	PERMEase
I3W_RS03935	COG1929	Belongs to the glycerate kinase type-1 family
I3W_RS03940	COG3257	ureidoglycine aminohydrolase activity
I3W_RS03945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3W_RS03950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I3W_RS03955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3W_RS03960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3W_RS03970	COG0549	Belongs to the carbamate kinase family
I3W_RS03975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3W_RS03980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3W_RS03995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3W_RS04005	COG1988	membrane-bound metal-dependent
I3W_RS04010	COG2501	S4 domain
I3W_RS04020	COG3539	Fimbrial protein
I3W_RS04025	COG3121	Chaperone
I3W_RS04030	COG3188	usher protein
I3W_RS04035	COG3539	Fimbrial protein
I3W_RS04040	COG3539	Fimbrial protein
I3W_RS04045	COG2197	response regulator
I3W_RS04055	COG0582	viral genome integration into host DNA
I3W_RS04075	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I3W_RS04080	COG5532	Uncharacterized conserved protein (DUF2303)
I3W_RS04125	COG1846	Transcriptional regulator
I3W_RS04140	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3W_RS04150	COG1403	HNH endonuclease
I3W_RS04170	COG3772	lysozyme
I3W_RS04185	COG5562	phage envelope protein
I3W_RS04210	COG4220	transposase activity
I3W_RS04230	COG1030	water channel activity
I3W_RS04280	COG1196	nuclear chromosome segregation
I3W_RS04315	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3W_RS04320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3W_RS04330	COG0500	methyltransferase
I3W_RS04345	COG4571	Outer membrane protease
I3W_RS04360	COG2207	Transcriptional regulator
I3W_RS04375	COG4783	chaperone-mediated protein folding
I3W_RS04380	COG1215	transferase activity, transferring glycosyl groups
I3W_RS04385	COG5433	transposase activity
I3W_RS04400	COG4104	PAAR repeat-containing protein
I3W_RS04400	COG3209	COG3209 Rhs family protein
I3W_RS04415	COG5002	protein histidine kinase activity
I3W_RS04420	COG0745	RESPONSE REGULATOR receiver
I3W_RS04430	COG1538	Outer membrane efflux protein
I3W_RS04435	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS04440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS04445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3W_RS04450	COG1113	amino acid transport
I3W_RS04455	COG0668	transmembrane transport
I3W_RS04460	COG0778	Nitroreductase
I3W_RS04465	COG2315	Protein conserved in bacteria
I3W_RS04500	COG2977	Belongs to the P-Pant transferase superfamily
I3W_RS04505	COG4771	TonB-dependent receptor
I3W_RS04510	COG2382	esterase
I3W_RS04515	COG3251	PFAM MbtH domain protein
I3W_RS04520	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3W_RS04520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3W_RS04525	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3W_RS04530	COG1120	ATPase activity
I3W_RS04535	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3W_RS04540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3W_RS04550	COG4592	Periplasmic binding protein
I3W_RS04560	COG1169	isochorismate synthase
I3W_RS04565	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3W_RS04570	COG3433	isochorismatase activity
I3W_RS04570	COG1535	isochorismatase
I3W_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS04580	COG2050	protein possibly involved in aromatic compounds catabolism
I3W_RS04585	COG1966	Carbon starvation protein
I3W_RS04590	COG2879	small protein
I3W_RS04595	COG0371	Dehydrogenase
I3W_RS04600	COG0436	Aminotransferase
I3W_RS04605	COG1475	DNA binding
I3W_RS04610	COG3969	phosphoadenosine phosphosulfate
I3W_RS04615	COG0583	DNA-binding transcription factor activity
I3W_RS04620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3W_RS04625	COG0450	alkyl hydroperoxide reductase
I3W_RS04635	COG3634	alkyl hydroperoxide reductase activity
I3W_RS04640	COG0589	response to stress
I3W_RS04645	COG1063	alcohol dehydrogenase
I3W_RS04655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3W_RS04665	COG3719	Belongs to the RNase T2 family
I3W_RS04670	COG0471	metal ion transport
I3W_RS04685	COG3051	citrate lyase alpha subunit
I3W_RS04690	COG2301	Belongs to the HpcH HpaI aldolase family
I3W_RS04700	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I3W_RS04705	COG3290	protein histidine kinase activity
I3W_RS04710	COG4565	transcriptional regulatory protein
I3W_RS04715	COG3069	C4-dicarboxylate transmembrane transporter activity
I3W_RS04740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3W_RS04745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3W_RS04760	COG0583	DNA-binding transcription factor activity
I3W_RS04780	COG1686	Belongs to the peptidase S11 family
I3W_RS04785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3W_RS04790	COG0772	Belongs to the SEDS family
I3W_RS04795	COG0768	penicillin binding
I3W_RS04805	COG0799	negative regulation of ribosome biogenesis
I3W_RS04810	COG0406	alpha-ribazole phosphatase activity
I3W_RS04820	COG1466	dna polymerase III delta subunit
I3W_RS04835	COG2888	peptidyl-tyrosine sulfation
I3W_RS04840	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3W_RS04850	COG2214	Heat shock protein DnaJ domain protein
I3W_RS04855	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3W_RS04865	COG2214	Heat shock protein DnaJ domain protein
I3W_RS04870	COG0443	Heat shock 70 kDa protein
I3W_RS04880	COG1126	abc transporter atp-binding protein
I3W_RS04885	COG0765	amino acid transport
I3W_RS04890	COG0765	amino acid transport
I3W_RS04895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS04910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I3W_RS04915	COG4535	Mg2 and Co2 transporter CorC
I3W_RS04925	COG1702	phosphate starvation-inducible protein PhoH
I3W_RS04935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3W_RS04980	COG0367	asparagine synthase
I3W_RS04990	COG0647	UMP catabolic process
I3W_RS04995	COG1940	carbohydrate kinase activity
I3W_RS04995	COG1846	Transcriptional regulator
I3W_RS05000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3W_RS05010	COG1263	PTS System
I3W_RS05010	COG2190	(PTS) system
I3W_RS05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS05035	COG0735	belongs to the Fur family
I3W_RS05045	COG0716	FMN binding
I3W_RS05055	COG0596	Alpha beta hydrolase
I3W_RS05060	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I3W_RS05065	COG0033	Phosphoglucomutase
I3W_RS05070	COG0531	amino acid
I3W_RS05075	COG1982	Orn Lys Arg decarboxylase major
I3W_RS05090	COG0745	RESPONSE REGULATOR receiver
I3W_RS05095	COG2205	protein histidine kinase activity
I3W_RS05125	COG3209	COG3209 Rhs family protein
I3W_RS05155	COG3272	Protein of unknown function (DUF1722)
I3W_RS05160	COG0415	Belongs to the DNA photolyase family
I3W_RS05170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3W_RS05175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3W_RS05180	COG1984	allophanate hydrolase subunit 2
I3W_RS05195	COG3180	Ammonia monooxygenase
I3W_RS05200	COG3539	Fimbrial protein
I3W_RS05205	COG3121	Chaperone
I3W_RS05210	COG3188	usher protein
I3W_RS05215	COG3539	Fimbrial protein
I3W_RS05220	COG0372	Belongs to the citrate synthase family
I3W_RS05235	COG2009	succinate dehydrogenase
I3W_RS05240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I3W_RS05245	COG1053	succinate dehydrogenase
I3W_RS05250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3W_RS05255	COG0567	Dehydrogenase, E1 component
I3W_RS05260	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3W_RS05270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3W_RS05275	COG2188	Transcriptional regulator
I3W_RS05280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS05280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS05280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS05285	COG0383	alpha-mannosidase activity
I3W_RS05295	COG1271	oxidase subunit
I3W_RS05300	COG1294	oxidase, subunit
I3W_RS05305	COG4890	Cyd operon protein YbgT
I3W_RS05310	COG3790	cyd operon protein YbgE
I3W_RS05315	COG0824	Thioesterase
I3W_RS05320	COG0811	peptide transport
I3W_RS05325	COG0848	biopolymer transport protein
I3W_RS05330	COG3064	Membrane
I3W_RS05340	COG2885	chlorophyll binding
I3W_RS05345	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I3W_RS05395	COG3201	nicotinamide mononucleotide transporter
I3W_RS05400	COG1230	cation diffusion facilitator family transporter
I3W_RS05415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3W_RS05425	COG2017	converts alpha-aldose to the beta-anomer
I3W_RS05435	COG1085	galactose-1-phosphate uridylyltransferase
I3W_RS05440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3W_RS05445	COG1119	ATPase activity
I3W_RS05450	COG3585	molybdate ion transport
I3W_RS05450	COG2005	Transcriptional regulator
I3W_RS05465	COG0725	ABC transporter, periplasmic molybdate-binding protein
I3W_RS05470	COG4149	molybdate abc transporter
I3W_RS05480	COG0561	phosphatase activity
I3W_RS05490	COG0583	DNA-binding transcription factor activity
I3W_RS05495	COG2828	Protein conserved in bacteria
I3W_RS05500	COG0471	metal ion transport
I3W_RS05505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3W_RS05510	COG4677	pectinesterase activity
I3W_RS05520	COG1881	PFAM PEBP family protein
I3W_RS05525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3W_RS05540	COG2226	methyltransferase
I3W_RS05545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3W_RS05555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3W_RS05565	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3W_RS05575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I3W_RS05580	COG0314	molybdopterin synthase activity
I3W_RS05585	COG0670	Belongs to the BI1 family
I3W_RS05595	COG0670	Belongs to the BI1 family
I3W_RS05600	COG0392	lysyltransferase activity
I3W_RS05605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3W_RS05610	COG3568	Endonuclease Exonuclease Phosphatase
I3W_RS05620	COG0842	Transport permease protein
I3W_RS05625	COG0842	Transport permease protein
I3W_RS05630	COG1131	(ABC) transporter
I3W_RS05640	COG1309	transcriptional regulator
I3W_RS05645	COG0513	Belongs to the DEAD box helicase family
I3W_RS05655	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS05660	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I3W_RS05670	COG1199	ATP-dependent helicase activity
I3W_RS05675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3W_RS05680	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I3W_RS05690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3W_RS05700	COG4774	siderophore transport
I3W_RS05715	COG0668	transmembrane transport
I3W_RS05720	COG1126	abc transporter atp-binding protein
I3W_RS05725	COG0765	amino acid transport
I3W_RS05730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS05755	COG5006	permease, DMT superfamily
I3W_RS05760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I3W_RS05765	COG2194	sulfuric ester hydrolase activity
I3W_RS05775	COG1321	iron dependent repressor
I3W_RS05780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3W_RS05785	COG1376	ErfK ybiS ycfS ynhG family protein
I3W_RS05790	COG0488	(ABC) transporter
I3W_RS05800	COG0561	phosphatase activity
I3W_RS05805	COG1882	Formate acetyltransferase
I3W_RS05810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3W_RS05815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3W_RS05820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3W_RS05825	COG0303	'Molybdopterin
I3W_RS05830	COG1446	asparaginase
I3W_RS05855	COG2200	EAL domain
I3W_RS05860	COG2199	diguanylate cyclase activity
I3W_RS05875	COG2133	pyrroloquinoline quinone binding
I3W_RS05880	COG0625	glutathione transferase activity
I3W_RS05885	COG1686	Belongs to the peptidase S11 family
I3W_RS05890	COG1349	DNA-binding transcription factor activity
I3W_RS05895	COG0671	phosphoesterase, PA-phosphatase related
I3W_RS05900	COG2814	Major facilitator Superfamily
I3W_RS05910	COG0561	phosphatase activity
I3W_RS05915	COG0738	Major facilitator superfamily
I3W_RS05920	COG3226	Transcriptional regulator
I3W_RS05935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3W_RS05945	COG0778	Nitroreductase
I3W_RS05965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3W_RS05970	COG3842	ATPase activity
I3W_RS05975	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3W_RS05980	COG1177	transmembrane transport
I3W_RS05995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS06000	COG4160	amino acid transport
I3W_RS06005	COG4215	(ABC) transporter
I3W_RS06010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS06015	COG1126	abc transporter atp-binding protein
I3W_RS06030	COG3023	N-Acetylmuramoyl-L-alanine amidase
I3W_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3W_RS06040	COG0702	epimerase
I3W_RS06045	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I3W_RS06050	COG0028	Belongs to the TPP enzyme family
I3W_RS06055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3W_RS06065	COG2431	L-lysine efflux transmembrane transporter activity
I3W_RS06075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3W_RS06080	COG3593	DNA synthesis involved in DNA repair
I3W_RS06085	COG2990	Protein conserved in bacteria
I3W_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS06100	COG1278	Cold shock
I3W_RS06110	COG0542	response to heat
I3W_RS06130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3W_RS06135	COG4988	ABC transporter
I3W_RS06140	COG0492	ferredoxin-NADP+ reductase activity
I3W_RS06150	COG1522	sequence-specific DNA binding
I3W_RS06165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3W_RS06175	COG0243	molybdopterin cofactor binding
I3W_RS06180	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS06185	COG3302	dmso reductase anchor subunit
I3W_RS06190	COG1335	isochorismatase
I3W_RS06200	COG0531	amino acid
I3W_RS06205	COG0583	DNA-binding transcription factor activity
I3W_RS06210	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3W_RS06215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3W_RS06220	COG1882	Formate acetyltransferase
I3W_RS06225	COG2116	formate transmembrane transporter activity
I3W_RS06230	COG1944	ATP diphosphatase activity
I3W_RS06235	COG2323	membrane
I3W_RS06250	COG0501	Belongs to the peptidase M48B family
I3W_RS06260	COG0539	negative regulation of cytoplasmic translation
I3W_RS06270	COG2333	competence protein COMEC
I3W_RS06270	COG0658	competence protein
I3W_RS06275	COG1132	(ABC) transporter
I3W_RS06285	COG3214	Protein conserved in bacteria
I3W_RS06300	COG3173	Aminoglycoside phosphotransferase
I3W_RS06305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3W_RS06310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3W_RS06320	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I3W_RS06330	COG2989	Protein conserved in bacteria
I3W_RS06340	COG3108	Peptidase M15
I3W_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3W_RS06350	COG1448	Aminotransferase
I3W_RS06370	COG0308	aminopeptidase N
I3W_RS06380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3W_RS06390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3W_RS06395	COG0431	NADPH-dependent FMN reductase
I3W_RS06405	COG3539	Fimbrial protein
I3W_RS06410	COG3121	Chaperone
I3W_RS06415	COG3188	usher protein
I3W_RS06420	COG3539	Fimbrial protein
I3W_RS06425	COG3539	Fimbrial protein
I3W_RS06430	COG3539	Fimbrial protein
I3W_RS06435	COG3121	Chaperone
I3W_RS06450	COG3217	Mosc domain protein beta barrel domain protein
I3W_RS06450	COG0633	Ferredoxin
I3W_RS06460	COG0488	(ABC) transporter
I3W_RS06465	COG2995	paraquat-inducible protein a
I3W_RS06470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3W_RS06470	COG3008	intermembrane lipid transfer
I3W_RS06475	COG3009	Protein conserved in bacteria
I3W_RS06480	COG3130	regulation of translation
I3W_RS06490	COG1067	ATP-dependent peptidase activity
I3W_RS06500	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I3W_RS06500	COG2885	chlorophyll binding
I3W_RS06515	COG3070	regulator of competence-specific genes
I3W_RS06520	COG1289	transmembrane transporter activity
I3W_RS06525	COG3304	Inner membrane component domain
I3W_RS06530	COG0210	DNA helicase
I3W_RS06545	COG1832	CoA-binding protein
I3W_RS06560	COG1254	Belongs to the acylphosphatase family
I3W_RS06565	COG2920	part of a sulfur-relay system
I3W_RS06570	COG0670	Belongs to the BI1 family
I3W_RS06580	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I3W_RS06585	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I3W_RS06590	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I3W_RS06595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3W_RS06600	COG1999	signal sequence binding
I3W_RS06605	COG1773	rubredoxin
I3W_RS06610	COG1271	oxidase subunit
I3W_RS06615	COG1294	oxidase, subunit
I3W_RS06630	COG3206	protein involved in exopolysaccharide biosynthesis
I3W_RS06630	COG0489	protein tyrosine kinase activity
I3W_RS06635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3W_RS06640	COG1596	polysaccharide export
I3W_RS06645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3W_RS06665	COG1278	Cold shock
I3W_RS06670	COG1278	Cold shock
I3W_RS06690	COG0348	domain, Protein
I3W_RS06695	COG2205	protein histidine kinase activity
I3W_RS06695	COG0784	Response regulator, receiver
I3W_RS06695	COG2198	Histidine kinase
I3W_RS06700	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS06705	COG0745	RESPONSE REGULATOR receiver
I3W_RS06710	COG3005	denitrification pathway
I3W_RS06715	COG0243	molybdopterin cofactor binding
I3W_RS06755	COG0582	viral genome integration into host DNA
I3W_RS06815	COG3093	addiction module antidote protein HigA
I3W_RS06860	COG5532	Uncharacterized conserved protein (DUF2303)
I3W_RS06900	COG3646	Phage regulatory protein
I3W_RS07010	COG3772	lysozyme
I3W_RS07025	COG3646	Phage regulatory protein
I3W_RS07165	COG3729	General stress protein
I3W_RS07170	COG2233	PERMEase
I3W_RS07205	COG1309	transcriptional regulator
I3W_RS07210	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3W_RS07210	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3W_RS07210	COG0506	proline dehydrogenase activity
I3W_RS07225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3W_RS07245	COG2822	iron ion transport
I3W_RS07255	COG1702	phosphate starvation-inducible protein PhoH
I3W_RS07260	COG3658	cytochrome
I3W_RS07265	COG1215	transferase activity, transferring glycosyl groups
I3W_RS07270	COG1649	PFAM Uncharacterised BCR, COG1649
I3W_RS07270	COG0726	polysaccharide deacetylase
I3W_RS07275	COG0457	Tetratricopeptide repeat
I3W_RS07280	COG3706	GGDEF domain
I3W_RS07315	COG3381	protein complex oligomerization
I3W_RS07325	COG1462	curli production assembly transport component CsgG
I3W_RS07340	COG2197	response regulator
I3W_RS07375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3W_RS07380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3W_RS07405	COG2943	transferase activity, transferring hexosyl groups
I3W_RS07410	COG5645	(Lipo)protein
I3W_RS07425	COG1560	Kdo2-lipid A biosynthetic process
I3W_RS07435	COG2353	YceI-like domain
I3W_RS07440	COG3038	cytochrome b561
I3W_RS07480	COG2999	glutathione oxidoreductase activity
I3W_RS07490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3W_RS07500	COG0673	inositol 2-dehydrogenase activity
I3W_RS07505	COG0728	peptidoglycan biosynthetic process
I3W_RS07510	COG3418	PFAM FlgN family protein
I3W_RS07515	COG2747	anti-sigma28 factor FlgM
I3W_RS07520	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I3W_RS07525	COG1815	bacterial-type flagellum-dependent cell motility
I3W_RS07530	COG1558	bacterial-type flagellum-dependent cell motility
I3W_RS07535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I3W_RS07540	COG1749	Flagellar hook protein flgE
I3W_RS07545	COG4787	bacterial-type flagellum-dependent cell motility
I3W_RS07550	COG4786	Flagellar basal body rod
I3W_RS07565	COG3951	Flagellar rod assembly protein muramidase FlgJ
I3W_RS07565	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3W_RS07570	COG1256	bacterial-type flagellum assembly
I3W_RS07575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3W_RS07580	COG1530	ribonuclease E activity
I3W_RS07590	COG0564	pseudouridine synthase activity
I3W_RS07595	COG0424	maF-like protein
I3W_RS07600	COG1399	metal-binding, possibly nucleic acid-binding protein
I3W_RS07620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I3W_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS07635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3W_RS07640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3W_RS07645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3W_RS07655	COG0470	DNA polymerase III
I3W_RS07660	COG0084	hydrolase, TatD family'
I3W_RS07665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS07665	COG1263	PTS System
I3W_RS07670	COG4773	Receptor
I3W_RS07675	COG0537	adenosine 5'-monophosphoramidase activity
I3W_RS07680	COG5633	Lipoprotein
I3W_RS07685	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I3W_RS07705	COG1252	NADH dehydrogenase
I3W_RS07715	COG3134	Outer membrane lipoprotein
I3W_RS07720	COG1309	transcriptional regulator
I3W_RS07730	COG1376	ErfK ybiS ycfS ynhG family protein
I3W_RS07730	COG1388	LysM domain
I3W_RS07735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I3W_RS07740	COG4763	Acyl-transferase
I3W_RS07745	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3W_RS07750	COG1136	(ABC) transporter
I3W_RS07755	COG4591	ABC-type transport system involved in lipoprotein release permease component
I3W_RS07765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3W_RS07770	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I3W_RS07780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3W_RS07785	COG1177	transmembrane transport
I3W_RS07795	COG3842	ATPase activity
I3W_RS07810	COG2850	peptidyl-arginine hydroxylation
I3W_RS07815	COG2205	protein histidine kinase activity
I3W_RS07825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3W_RS07845	COG1187	pseudouridine synthase activity
I3W_RS07850	COG0538	isocitrate dehydrogenase activity
I3W_RS07860	COG5562	phage envelope protein
I3W_RS07865	COG0789	Transcriptional regulator
I3W_RS07870	COG2200	EAL domain
I3W_RS07895	COG2200	EAL domain
I3W_RS07955	COG2894	cell division
I3W_RS07985	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3W_RS08000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3W_RS08005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3W_RS08025	COG2719	SpoVR family
I3W_RS08035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3W_RS08050	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3W_RS08065	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I3W_RS08090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3W_RS08090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS08090	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I3W_RS08095	COG1461	Dihydroxyacetone kinase
I3W_RS08100	COG2376	Dihydroxyacetone kinase
I3W_RS08105	COG3284	Transcriptional regulator
I3W_RS08110	COG3468	outer membrane autotransporter barrel domain protein
I3W_RS08125	COG0012	GTP binding
I3W_RS08140	COG0659	secondary active sulfate transmembrane transporter activity
I3W_RS08150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3W_RS08180	COG2890	protein-(glutamine-N5) methyltransferase activity
I3W_RS08185	COG3094	Invasion gene expression up-regulator, SirB
I3W_RS08190	COG2912	Transglutaminase-like superfamily
I3W_RS08220	COG0387	Pfam Sodium calcium exchanger
I3W_RS08230	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I3W_RS08235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I3W_RS08245	COG2197	response regulator
I3W_RS08250	COG3850	Histidine kinase
I3W_RS08260	COG2223	nitrite transmembrane transporter activity
I3W_RS08265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3W_RS08270	COG1140	nitrate reductase beta subunit
I3W_RS08275	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3W_RS08280	COG2181	nitrate reductase activity
I3W_RS08300	COG0788	formyltetrahydrofolate deformylase activity
I3W_RS08310	COG1752	Esterase of the alpha-beta hydrolase superfamily
I3W_RS08315	COG0745	RESPONSE REGULATOR receiver
I3W_RS08320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3W_RS08330	COG1435	thymidine kinase activity
I3W_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS08340	COG1454	alcohol dehydrogenase
I3W_RS08345	COG2095	MarC family integral membrane protein
I3W_RS08355	COG4166	transmembrane transport
I3W_RS08360	COG0601	transmembrane transport
I3W_RS08365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3W_RS08370	COG0444	Belongs to the ABC transporter superfamily
I3W_RS08375	COG4608	Belongs to the ABC transporter superfamily
I3W_RS08395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3W_RS08400	COG2350	Protein conserved in bacteria
I3W_RS08410	COG1607	acyl-coa hydrolase
I3W_RS08430	COG3047	cAMP biosynthetic process
I3W_RS08435	COG0582	viral genome integration into host DNA
I3W_RS08445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3W_RS08480	COG1396	sequence-specific DNA binding
I3W_RS08495	COG1846	Transcriptional regulator
I3W_RS08500	COG1484	DNA-dependent DNA replication
I3W_RS08505	COG1846	Transcriptional regulator
I3W_RS08550	COG1403	HNH endonuclease
I3W_RS08555	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3W_RS08590	COG3064	Membrane
I3W_RS08600	COG2207	Transcriptional regulator
I3W_RS08785	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3W_RS08810	COG3685	Protein conserved in bacteria
I3W_RS08815	COG3685	Protein conserved in bacteria
I3W_RS08820	COG3729	General stress protein
I3W_RS08835	COG0135	phosphoribosylanthranilate isomerase activity
I3W_RS08835	COG0134	indole-3-glycerol-phosphate synthase activity
I3W_RS08840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3W_RS08840	COG0512	Glutamine amidotransferase of anthranilate synthase
I3W_RS08845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3W_RS08855	COG0613	PHP domain protein
I3W_RS08860	COG0009	L-threonylcarbamoyladenylate synthase
I3W_RS08865	COG1187	pseudouridine synthase activity
I3W_RS08870	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I3W_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS08880	COG0616	signal peptide processing
I3W_RS08895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3W_RS08905	COG0583	DNA-binding transcription factor activity
I3W_RS08925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3W_RS08935	COG0671	phosphoesterase, PA-phosphatase related
I3W_RS08940	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I3W_RS08945	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I3W_RS08955	COG0023	Translation Initiation Factor
I3W_RS08965	COG1349	DNA-binding transcription factor activity
I3W_RS08975	COG5001	Diguanylate cyclase
I3W_RS08990	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3W_RS08990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3W_RS08995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3W_RS09000	COG2852	Protein conserved in bacteria
I3W_RS09005	COG4172	Belongs to the ABC transporter superfamily
I3W_RS09010	COG4172	Belongs to the ABC transporter superfamily
I3W_RS09015	COG4171	peptide transport system, permease
I3W_RS09020	COG4168	peptide transport system, permease
I3W_RS09025	COG4166	transmembrane transport
I3W_RS09040	COG0531	amino acid
I3W_RS09045	COG0174	glutamine synthetase
I3W_RS09050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3W_RS09055	COG1396	sequence-specific DNA binding
I3W_RS09055	COG1917	Cupin 2, conserved barrel domain protein
I3W_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS09070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3W_RS09075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3W_RS09080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I3W_RS09085	COG1842	Phage shock protein A
I3W_RS09095	COG1983	PspC domain protein
I3W_RS09105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3W_RS09110	COG0366	Alpha amylase catalytic
I3W_RS09115	COG1653	transport
I3W_RS09120	COG1175	transmembrane transport
I3W_RS09125	COG0395	ABC-type sugar transport system, permease component
I3W_RS09130	COG1063	alcohol dehydrogenase
I3W_RS09135	COG1082	Xylose isomerase domain protein TIM barrel
I3W_RS09140	COG0673	inositol 2-dehydrogenase activity
I3W_RS09145	COG1554	hydrolase, family 65, central catalytic
I3W_RS09150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3W_RS09155	COG3842	ATPase activity
I3W_RS09165	COG1609	Transcriptional regulator
I3W_RS09170	COG3106	COG3106 Predicted ATPase
I3W_RS09180	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I3W_RS09185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I3W_RS09190	COG4948	Mandelate Racemase Muconate Lactonizing
I3W_RS09195	COG2866	Carboxypeptidase
I3W_RS09200	COG0702	epimerase
I3W_RS09205	COG1073	alpha beta
I3W_RS09210	COG1073	alpha beta
I3W_RS09215	COG0583	DNA-binding transcription factor activity
I3W_RS09220	COG4166	transmembrane transport
I3W_RS09225	COG0668	transmembrane transport
I3W_RS09230	COG3182	Iron-regulated membrane protein
I3W_RS09235	COG0589	response to stress
I3W_RS09240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3W_RS09245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3W_RS09250	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I3W_RS09260	COG1473	amidohydrolase
I3W_RS09265	COG1473	amidohydrolase
I3W_RS09270	COG0583	DNA-binding transcription factor activity
I3W_RS09275	COG2840	Smr protein MutS2
I3W_RS09280	COG3706	GGDEF domain
I3W_RS09295	COG0513	Belongs to the DEAD box helicase family
I3W_RS09305	COG0589	response to stress
I3W_RS09310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3W_RS09320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3W_RS09320	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3W_RS09320	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3W_RS09320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3W_RS09325	COG3042	response to heat
I3W_RS09330	COG3187	Heat shock protein
I3W_RS09335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3W_RS09340	COG2911	Protein conserved in bacteria
I3W_RS09350	COG3784	Protein of unknown function (DUF1318)
I3W_RS09355	COG2207	Transcriptional regulator
I3W_RS09360	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS09370	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS09370	COG2030	dehydratase
I3W_RS09375	COG3396	Phenylacetate-CoA oxygenase
I3W_RS09380	COG3460	Phenylacetate-CoA oxygenase
I3W_RS09385	COG3396	Phenylacetate-CoA oxygenase
I3W_RS09390	COG2151	metal-sulfur cluster biosynthetic enzyme
I3W_RS09395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3W_RS09400	COG1024	Enoyl-CoA hydratase
I3W_RS09405	COG1024	Enoyl-CoA hydratase
I3W_RS09410	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3W_RS09415	COG2050	protein possibly involved in aromatic compounds catabolism
I3W_RS09420	COG0183	Belongs to the thiolase family
I3W_RS09425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I3W_RS09430	COG3327	negative regulation of DNA-templated transcription, initiation
I3W_RS09435	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3W_RS09440	COG0667	Aldo Keto reductase
I3W_RS09450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3W_RS09455	COG4589	Belongs to the CDS family
I3W_RS09460	COG2267	carboxylic ester hydrolase activity
I3W_RS09465	COG2453	phosphatase
I3W_RS09465	COG0671	phosphoesterase, PA-phosphatase related
I3W_RS09475	COG1643	Atp-dependent helicase
I3W_RS09480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I3W_RS09485	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS09490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3W_RS09495	COG3038	cytochrome b561
I3W_RS09510	COG0840	transmembrane signaling receptor activity
I3W_RS09515	COG0583	DNA-binding transcription factor activity
I3W_RS09520	COG5383	Protein conserved in bacteria
I3W_RS09540	COG2841	Protein conserved in bacteria
I3W_RS09545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3W_RS09550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3W_RS09555	COG1275	C4-dicarboxylate transporter malic acid transport protein
I3W_RS09560	COG0500	methyltransferase
I3W_RS09575	COG0675	Transposase, IS605 OrfB family
I3W_RS09580	COG3135	benzoate transporter
I3W_RS09585	COG1396	sequence-specific DNA binding
I3W_RS09590	COG0826	peptidase U32
I3W_RS09600	COG1724	mRNA binding
I3W_RS09605	COG1598	PFAM Uncharacterised protein family UPF0150
I3W_RS09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3W_RS09615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I3W_RS09620	COG3842	ATPase activity
I3W_RS09625	COG1176	ABC-type spermidine putrescine transport system, permease component I
I3W_RS09630	COG1177	transmembrane transport
I3W_RS09665	COG3238	Protein conserved in bacteria
I3W_RS09670	COG1247	-acetyltransferase
I3W_RS09680	COG2130	NADP-dependent
I3W_RS09685	COG1802	Transcriptional regulator
I3W_RS09690	COG4772	TonB-dependent receptor
I3W_RS09705	COG3391	amine dehydrogenase activity
I3W_RS09710	COG1113	amino acid transport
I3W_RS09715	COG0625	glutathione transferase activity
I3W_RS09730	COG3209	COG3209 Rhs family protein
I3W_RS09765	COG3209	COG3209 Rhs family protein
I3W_RS09785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3W_RS09790	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I3W_RS09795	COG0384	phenazine biosynthesis protein PhzF
I3W_RS09800	COG2181	nitrate reductase activity
I3W_RS09805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3W_RS09810	COG1140	nitrate reductase beta subunit
I3W_RS09815	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3W_RS09820	COG2223	nitrite transmembrane transporter activity
I3W_RS09825	COG4886	Leucine-rich repeat (LRR) protein
I3W_RS09830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3W_RS09835	COG0697	spore germination
I3W_RS09840	COG0243	molybdopterin cofactor binding
I3W_RS09840	COG3383	formate dehydrogenase (NAD+) activity
I3W_RS09845	COG3383	formate dehydrogenase (NAD+) activity
I3W_RS09845	COG0243	molybdopterin cofactor binding
I3W_RS09850	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS09855	COG2864	formate dehydrogenase
I3W_RS09860	COG3093	addiction module antidote protein HigA
I3W_RS09865	COG1064	alcohol dehydrogenase
I3W_RS09890	COG1764	response to oxidative stress
I3W_RS09900	COG0444	Belongs to the ABC transporter superfamily
I3W_RS09905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3W_RS09910	COG0601	transmembrane transport
I3W_RS09915	COG0747	negative chemotaxis
I3W_RS09920	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I3W_RS09925	COG2200	EAL domain
I3W_RS09925	COG2202	Pas domain
I3W_RS09925	COG2199	diguanylate cyclase activity
I3W_RS09935	COG1649	PFAM Uncharacterised BCR, COG1649
I3W_RS09940	COG0531	amino acid
I3W_RS09945	COG0076	glutamate decarboxylase activity
I3W_RS09950	COG0612	Peptidase, M16
I3W_RS09955	COG4771	TonB-dependent receptor
I3W_RS09960	COG4178	(ABC) transporter
I3W_RS09965	COG0641	radical SAM
I3W_RS09970	COG3119	arylsulfatase activity
I3W_RS09975	COG2207	Transcriptional regulator
I3W_RS09985	COG0243	molybdopterin cofactor binding
I3W_RS09990	COG3539	Fimbrial protein
I3W_RS09995	COG3539	Fimbrial protein
I3W_RS10000	COG3539	Fimbrial protein
I3W_RS10005	COG3188	usher protein
I3W_RS10015	COG3539	Fimbrial protein
I3W_RS10035	COG3550	peptidyl-serine autophosphorylation
I3W_RS10040	COG1396	sequence-specific DNA binding
I3W_RS10045	COG3210	domain, Protein
I3W_RS10045	COG2911	Protein conserved in bacteria
I3W_RS10095	COG3781	membrane
I3W_RS10115	COG2199	diguanylate cyclase activity
I3W_RS10130	COG2066	Belongs to the glutaminase family
I3W_RS10135	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS10140	COG0583	DNA-binding transcription factor activity
I3W_RS10160	COG1846	Transcriptional regulator
I3W_RS10165	COG4977	sequence-specific DNA binding
I3W_RS10175	COG2723	6-phospho-beta-galactosidase activity
I3W_RS10185	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3W_RS10190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3W_RS10200	COG2188	Transcriptional regulator
I3W_RS10205	COG0697	spore germination
I3W_RS10210	COG2814	Major facilitator Superfamily
I3W_RS10220	COG3706	GGDEF domain
I3W_RS10225	COG3111	PFAM Bacterial OB fold (BOF) protein
I3W_RS10230	COG1546	Belongs to the CinA family
I3W_RS10240	COG0339	signal peptide processing
I3W_RS10250	COG4221	oxidoreductase activity
I3W_RS10255	COG1802	Transcriptional regulator
I3W_RS10265	COG0246	Mannitol dehydrogenase
I3W_RS10270	COG0477	Major facilitator Superfamily
I3W_RS10280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3W_RS10285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3W_RS10290	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3W_RS10375	COG1030	water channel activity
I3W_RS10395	COG4220	transposase activity
I3W_RS10410	COG5562	phage envelope protein
I3W_RS10430	COG1278	Cold shock
I3W_RS10440	COG3772	lysozyme
I3W_RS10455	COG1278	Cold shock
I3W_RS10460	COG1278	Cold shock
I3W_RS10465	COG0484	heat shock protein binding
I3W_RS10470	COG1403	HNH endonuclease
I3W_RS10490	COG2026	Addiction module toxin, RelE StbE family
I3W_RS10495	COG3077	Addiction module antitoxin, RelB DinJ family
I3W_RS10515	COG2801	Transposase and inactivated derivatives
I3W_RS10540	COG1846	Transcriptional regulator
I3W_RS10555	COG1396	sequence-specific DNA binding
I3W_RS10590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3W_RS10600	COG0582	viral genome integration into host DNA
I3W_RS10610	COG1063	alcohol dehydrogenase
I3W_RS10615	COG4948	Mandelate Racemase Muconate Lactonizing
I3W_RS10635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3W_RS10650	COG0243	molybdopterin cofactor binding
I3W_RS10655	COG0243	molybdopterin cofactor binding
I3W_RS10660	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS10665	COG3302	dmso reductase anchor subunit
I3W_RS10670	COG3381	protein complex oligomerization
I3W_RS10680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I3W_RS10685	COG1940	carbohydrate kinase activity
I3W_RS10690	COG0583	DNA-binding transcription factor activity
I3W_RS10695	COG2814	Major facilitator Superfamily
I3W_RS10715	COG3591	Belongs to the peptidase S1B family
I3W_RS10740	COG1802	Transcriptional regulator
I3W_RS10740	COG4626	Terminase
I3W_RS10875	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I3W_RS10880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I3W_RS10895	COG0531	amino acid
I3W_RS10905	COG3136	membrane protein required for alginate biosynthesis
I3W_RS10910	COG0745	RESPONSE REGULATOR receiver
I3W_RS10915	COG2205	protein histidine kinase activity
I3W_RS10925	COG0114	fumarate hydratase activity
I3W_RS10930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3W_RS10930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3W_RS10935	COG1482	cell wall glycoprotein biosynthetic process
I3W_RS10940	COG5339	Protein conserved in bacteria
I3W_RS10955	COG3250	beta-galactosidase activity
I3W_RS10960	COG1309	transcriptional regulator
I3W_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS10970	COG1609	Transcriptional regulator
I3W_RS10975	COG1263	PTS System
I3W_RS10975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS10980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3W_RS10990	COG0673	inositol 2-dehydrogenase activity
I3W_RS11035	COG4659	FMN binding
I3W_RS11045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I3W_RS11055	COG3104	oligopeptide transport
I3W_RS11060	COG0625	glutathione transferase activity
I3W_RS11065	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I3W_RS11080	COG3895	Periplasmic Protein
I3W_RS11090	COG3133	Outer membrane lipoprotein
I3W_RS11105	COG1566	PFAM secretion protein HlyD family protein
I3W_RS11110	COG1289	transmembrane transporter activity
I3W_RS11115	COG2032	superoxide dismutase activity
I3W_RS11120	COG4989	oxidoreductase activity
I3W_RS11125	COG3313	Fe-S protein
I3W_RS11130	COG1309	transcriptional regulator
I3W_RS11135	COG1902	pentaerythritol trinitrate reductase activity
I3W_RS11140	COG0346	lactoylglutathione lyase activity
I3W_RS11150	COG1201	RNA secondary structure unwinding
I3W_RS11155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I3W_RS11160	COG0791	NLP P60 protein
I3W_RS11165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3W_RS11170	COG2814	Major facilitator Superfamily
I3W_RS11190	COG0583	DNA-binding transcription factor activity
I3W_RS11195	COG2814	Major facilitator Superfamily
I3W_RS11200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3W_RS11205	COG0307	riboflavin synthase, alpha
I3W_RS11215	COG3468	outer membrane autotransporter barrel domain protein
I3W_RS11235	COG4529	Protein conserved in bacteria
I3W_RS11245	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I3W_RS11250	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS11260	COG2414	aldehyde ferredoxin oxidoreductase
I3W_RS11265	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS11275	COG0469	pyruvate kinase activity
I3W_RS11280	COG4238	major outer membrane lipoprotein
I3W_RS11285	COG1376	ErfK ybiS ycfS ynhG family protein
I3W_RS11300	COG0719	Fe-S assembly protein
I3W_RS11305	COG0396	ATPase activity
I3W_RS11310	COG0719	Fe-S assembly protein
I3W_RS11315	COG0316	Belongs to the HesB IscA family
I3W_RS11325	COG2050	protein possibly involved in aromatic compounds catabolism
I3W_RS11330	COG0277	FAD linked oxidase domain protein
I3W_RS11330	COG0247	lactate metabolic process
I3W_RS11340	COG0628	permease
I3W_RS11355	COG0738	Major facilitator superfamily
I3W_RS11360	COG2271	Major facilitator Superfamily
I3W_RS11375	COG4670	ketone body catabolic process
I3W_RS11380	COG1960	acyl-CoA dehydrogenase activity
I3W_RS11385	COG2207	Transcriptional regulator
I3W_RS11385	COG1917	Cupin 2, conserved barrel domain protein
I3W_RS11395	COG2086	electron transfer activity
I3W_RS11400	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3W_RS11405	COG0644	oxidoreductase
I3W_RS11410	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3W_RS11415	COG0318	PFAM AMP-dependent synthetase and ligase
I3W_RS11420	COG0574	Belongs to the PEP-utilizing enzyme family
I3W_RS11420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3W_RS11435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3W_RS11440	COG4256	Hemin uptake protein
I3W_RS11450	COG2200	EAL domain
I3W_RS11455	COG0791	NLP P60 protein
I3W_RS11465	COG0386	Belongs to the glutathione peroxidase family
I3W_RS11530	COG3137	Salt-induced outer membrane protein
I3W_RS11535	COG1105	Belongs to the carbohydrate kinase PfkB family
I3W_RS11545	COG3001	Fructosamine kinase
I3W_RS11555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3W_RS11560	COG1988	membrane-bound metal-dependent
I3W_RS11565	COG1823	symporter activity
I3W_RS11585	COG0753	catalase activity
I3W_RS11590	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS11605	COG1486	melibiose metabolic process
I3W_RS11610	COG1917	Cupin 2, conserved barrel domain protein
I3W_RS11610	COG2169	Transcriptional regulator
I3W_RS11615	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3W_RS11620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3W_RS11625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3W_RS11635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3W_RS11645	COG0322	excinuclease ABC activity
I3W_RS11655	COG3678	ATP-independent chaperone mediated protein folding
I3W_RS11690	COG0708	Exodeoxyribonuclease III
I3W_RS11695	COG0398	Pfam SNARE associated Golgi protein
I3W_RS11705	COG0398	Pfam SNARE associated Golgi protein
I3W_RS11710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3W_RS11715	COG4134	Bacterial extracellular solute-binding protein
I3W_RS11720	COG4135	transport system, permease component
I3W_RS11725	COG4136	ATPase activity
I3W_RS11730	COG2897	thiosulfate sulfurtransferase activity
I3W_RS11735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3W_RS11740	COG0494	nUDIX hydrolase
I3W_RS11750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3W_RS11760	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS11775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3W_RS11780	COG0709	Synthesizes selenophosphate from selenide and ATP
I3W_RS11790	COG0778	Nitroreductase
I3W_RS11800	COG0616	signal peptide processing
I3W_RS11805	COG0252	asparaginase activity
I3W_RS11810	COG1335	isochorismatase
I3W_RS11815	COG2814	Major facilitator Superfamily
I3W_RS11820	COG1349	DNA-binding transcription factor activity
I3W_RS11825	COG0667	Aldo Keto reductase
I3W_RS11830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS11835	COG0191	fructose-bisphosphate aldolase activity
I3W_RS11840	COG1063	alcohol dehydrogenase
I3W_RS11845	COG2271	Major facilitator Superfamily
I3W_RS11850	COG1063	alcohol dehydrogenase
I3W_RS11855	COG3139	Protein of unknown function (DUF1315)
I3W_RS11865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3W_RS11870	COG0676	glucose-6-phosphate 1-epimerase activity
I3W_RS11875	COG0656	L-ascorbic acid biosynthetic process
I3W_RS11880	COG3713	MltA-interacting MipA family protein
I3W_RS11885	COG2766	serine protein kinase
I3W_RS11895	COG2199	diguanylate cyclase activity
I3W_RS11900	COG2199	diguanylate cyclase activity
I3W_RS11905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3W_RS11920	COG2207	Transcriptional regulator
I3W_RS11925	COG2807	transmembrane transport
I3W_RS11930	COG3189	MarR family transcriptional regulator
I3W_RS11935	COG3042	response to heat
I3W_RS11940	COG2203	Gaf domain
I3W_RS11940	COG2199	diguanylate cyclase activity
I3W_RS11955	COG2261	transglycosylase associated protein
I3W_RS11960	COG0675	Transposase, IS605 OrfB family
I3W_RS11975	COG3615	Tellurite resistance protein tehB
I3W_RS11985	COG0583	DNA-binding transcription factor activity
I3W_RS11990	COG0473	3-isopropylmalate dehydrogenase activity
I3W_RS11995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3W_RS12000	COG4638	Rieske (2fe-2S)
I3W_RS12005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3W_RS12010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3W_RS12015	COG0318	PFAM AMP-dependent synthetase and ligase
I3W_RS12020	COG3065	identical protein binding
I3W_RS12025	COG1214	PFAM Peptidase M22, glycoprotease
I3W_RS12030	COG1199	ATP-dependent helicase activity
I3W_RS12035	COG0251	oxidation-reduction process
I3W_RS12050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3W_RS12060	COG1760	l-serine dehydratase
I3W_RS12065	COG2200	EAL domain
I3W_RS12070	COG1253	flavin adenine dinucleotide binding
I3W_RS12085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS12085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS12090	COG3715	PTS system
I3W_RS12095	COG3716	PTS system mannose fructose sorbose family IID component
I3W_RS12115	COG2226	methyltransferase
I3W_RS12150	COG1414	Transcriptional regulator
I3W_RS12155	COG2814	Major facilitator Superfamily
I3W_RS12165	COG0793	Belongs to the peptidase S41A family
I3W_RS12175	COG1956	GAF domain-containing protein
I3W_RS12180	COG2995	paraquat-inducible protein a
I3W_RS12185	COG3008	intermembrane lipid transfer
I3W_RS12205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3W_RS12215	COG1276	copper resistance
I3W_RS12220	COG2372	response to copper ion
I3W_RS12230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3W_RS12235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3W_RS12240	COG1770	oligopeptidase
I3W_RS12245	COG2979	Protein of unknown function (DUF533)
I3W_RS12255	COG3141	response to X-ray
I3W_RS12265	COG0800	Aldolase
I3W_RS12270	COG0129	dihydroxy-acid dehydratase activity
I3W_RS12275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I3W_RS12280	COG1737	Transcriptional regulator
I3W_RS12285	COG0469	pyruvate kinase activity
I3W_RS12310	COG3833	ABC-type maltose transport systems, permease component
I3W_RS12315	COG1175	transmembrane transport
I3W_RS12320	COG2182	Extracellular solute-binding protein
I3W_RS12330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I3W_RS12340	COG3842	ATPase activity
I3W_RS12360	COG1560	Kdo2-lipid A biosynthetic process
I3W_RS12365	COG0739	heme binding
I3W_RS12370	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I3W_RS12380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3W_RS12410	COG0217	transcriptional regulatory protein
I3W_RS12415	COG0494	nUDIX hydrolase
I3W_RS12425	COG1335	isochorismatase
I3W_RS12430	COG1801	Protein of unknown function DUF72
I3W_RS12435	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I3W_RS12450	COG0243	molybdopterin cofactor binding
I3W_RS12455	COG3005	denitrification pathway
I3W_RS12470	COG3102	Protein conserved in bacteria
I3W_RS12485	COG3755	Protein conserved in bacteria
I3W_RS12495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3W_RS12500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3W_RS12505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I3W_RS12510	COG0745	RESPONSE REGULATOR receiver
I3W_RS12515	COG2201	protein-glutamate methylesterase activity
I3W_RS12520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I3W_RS12525	COG0840	transmembrane signaling receptor activity
I3W_RS12530	COG0840	transmembrane signaling receptor activity
I3W_RS12535	COG0835	chemotaxis
I3W_RS12540	COG2198	Histidine kinase
I3W_RS12540	COG0643	Histidine kinase
I3W_RS12545	COG1360	Flagellar Motor Protein
I3W_RS12550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3W_RS12565	COG0589	response to stress
I3W_RS12575	COG1877	trehalose-phosphatase activity
I3W_RS12580	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS12585	COG1129	ABC transporter
I3W_RS12590	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS12600	COG1528	Iron-storage protein
I3W_RS12625	COG1528	Iron-storage protein
I3W_RS12635	COG0814	amino acid
I3W_RS12640	COG3012	SEC-C Motif Domain Protein
I3W_RS12640	COG3318	Belongs to the UPF0149 family
I3W_RS12670	COG2197	response regulator
I3W_RS12680	COG2197	response regulator
I3W_RS12685	COG1126	abc transporter atp-binding protein
I3W_RS12690	COG0765	amino acid transport
I3W_RS12700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS12710	COG1191	sigma factor activity
I3W_RS12725	COG1516	flagellar protein fliS
I3W_RS12735	COG0366	Alpha amylase catalytic
I3W_RS12750	COG2391	methyltransferase activity
I3W_RS12755	COG0425	Belongs to the sulfur carrier protein TusA family
I3W_RS12760	COG2135	peptidase activity
I3W_RS12780	COG1766	The M ring may be actively involved in energy transduction
I3W_RS12785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3W_RS12790	COG1317	bacterial-type flagellum organization
I3W_RS12795	COG1157	protein secretion by the type III secretion system
I3W_RS12800	COG2882	bacterial-type flagellum organization
I3W_RS12805	COG3144	bacterial-type flagellum assembly
I3W_RS12810	COG1580	Controls the rotational direction of flagella during chemotaxis
I3W_RS12815	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3W_RS12820	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3W_RS12825	COG3190	flagellar
I3W_RS12830	COG1338	Plays a role in the flagellum-specific transport system
I3W_RS12835	COG1987	bacterial-type flagellum assembly
I3W_RS12840	COG1684	flagellar biosynthetic protein fliR
I3W_RS12845	COG2197	response regulator
I3W_RS12875	COG5475	Uncharacterized small protein (DUF2158)
I3W_RS12880	COG2354	Protein conserved in bacteria
I3W_RS12885	COG0697	spore germination
I3W_RS12890	COG3727	T/G mismatch-specific endonuclease activity
I3W_RS12895	COG0270	DNA (cytosine-5-)-methyltransferase activity
I3W_RS12900	COG1418	mRNA catabolic process
I3W_RS12910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3W_RS12925	COG2205	protein histidine kinase activity
I3W_RS12930	COG0745	RESPONSE REGULATOR receiver
I3W_RS12935	COG2351	hydroxyisourate hydrolase activity
I3W_RS12955	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS12960	COG3443	Belongs to the bacterial solute-binding protein 9 family
I3W_RS12965	COG3038	cytochrome b561
I3W_RS13075	COG0616	signal peptide processing
I3W_RS13220	COG0305	Participates in initiation and elongation during chromosome replication
I3W_RS13300	COG1388	LysM domain
I3W_RS13300	COG4932	domain protein
I3W_RS13300	COG2373	Large extracellular alpha-helical protein
I3W_RS13305	COG1470	cell adhesion involved in biofilm formation
I3W_RS13305	COG1388	LysM domain
I3W_RS13315	COG0477	Major facilitator Superfamily
I3W_RS13320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3W_RS13325	COG0217	transcriptional regulatory protein
I3W_RS13340	COG0534	Mate efflux family protein
I3W_RS13350	COG0583	DNA-binding transcription factor activity
I3W_RS13355	COG0583	DNA-binding transcription factor activity
I3W_RS13365	COG1376	ErfK ybiS ycfS ynhG family protein
I3W_RS13380	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I3W_RS13385	COG4917	ethanolamine utilization protein
I3W_RS13400	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS13420	COG1686	Belongs to the peptidase S11 family
I3W_RS13425	COG2925	Exonuclease
I3W_RS13430	COG0425	Belongs to the sulfur carrier protein TusA family
I3W_RS13435	COG2391	methyltransferase activity
I3W_RS13440	COG0531	amino acid
I3W_RS13450	COG0583	DNA-binding transcription factor activity
I3W_RS13455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3W_RS13460	COG4115	mRNA cleavage
I3W_RS13465	COG2161	toxin-antitoxin pair type II binding
I3W_RS13495	COG0131	Imidazoleglycerol-phosphate dehydratase
I3W_RS13495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3W_RS13500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3W_RS13525	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3W_RS13530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3W_RS13535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3W_RS13540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3W_RS13560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3W_RS13565	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I3W_RS13585	COG0110	maltose O-acetyltransferase activity
I3W_RS13590	COG0463	Glycosyl transferase, family 2
I3W_RS13595	COG2244	polysaccharide biosynthetic process
I3W_RS13600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3W_RS13605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3W_RS13615	COG0438	transferase activity, transferring glycosyl groups
I3W_RS13620	COG2327	Polysaccharide pyruvyl transferase
I3W_RS13625	COG2244	polysaccharide biosynthetic process
I3W_RS13630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3W_RS13635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3W_RS13640	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I3W_RS13640	COG0662	Cupin 2, conserved barrel domain protein
I3W_RS13645	COG0297	glycogen (starch) synthase activity
I3W_RS13650	COG1051	belongs to the nudix hydrolase family
I3W_RS13655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3W_RS13660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I3W_RS13665	COG0110	maltose O-acetyltransferase activity
I3W_RS13670	COG1216	Glycosyl transferase, family 2
I3W_RS13680	COG0438	transferase activity, transferring glycosyl groups
I3W_RS13685	COG1045	serine acetyltransferase
I3W_RS13690	COG0463	Glycosyl transferase, family 2
I3W_RS13695	COG3206	protein involved in exopolysaccharide biosynthesis
I3W_RS13695	COG0489	protein tyrosine kinase activity
I3W_RS13700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3W_RS13705	COG1596	polysaccharide export
I3W_RS13710	COG1253	flavin adenine dinucleotide binding
I3W_RS13715	COG2982	Protein involved in outer membrane biogenesis
I3W_RS13725	COG0572	uridine kinase
I3W_RS13730	COG3447	MASE1 domain protein
I3W_RS13730	COG5002	protein histidine kinase activity
I3W_RS13730	COG5001	Diguanylate cyclase
I3W_RS13735	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I3W_RS13740	COG0443	Heat shock 70 kDa protein
I3W_RS13745	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I3W_RS13750	COG0631	protein serine/threonine phosphatase activity
I3W_RS13755	COG4245	von Willebrand factor, type A
I3W_RS13795	COG2205	protein histidine kinase activity
I3W_RS13800	COG0745	RESPONSE REGULATOR receiver
I3W_RS13810	COG3609	addiction module antidote protein, CC2985 family
I3W_RS13820	COG0826	peptidase U32
I3W_RS13845	COG1063	alcohol dehydrogenase
I3W_RS13850	COG3775	system Galactitol-specific IIC component
I3W_RS13855	COG3414	Phosphotransferase system galactitol-specific IIB component
I3W_RS13860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS13875	COG1830	Aldolase
I3W_RS13880	COG2211	Major facilitator Superfamily
I3W_RS13885	COG1397	ADP-ribosylglycohydrolase
I3W_RS13890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS13895	COG2188	Transcriptional regulator
I3W_RS13900	COG3757	hydrolase, family 25
I3W_RS13905	COG0351	phosphomethylpyrimidine kinase
I3W_RS13920	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I3W_RS13925	COG5455	response to cobalt ion
I3W_RS13930	COG3539	Fimbrial protein
I3W_RS13935	COG3188	usher protein
I3W_RS13940	COG3121	Chaperone
I3W_RS13945	COG3539	Fimbrial protein
I3W_RS13960	COG0489	protein tyrosine kinase activity
I3W_RS13970	COG3831	ATPase activity
I3W_RS13975	COG3831	ATPase activity
I3W_RS13985	COG0714	Associated with various cellular activities
I3W_RS13990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I3W_RS13995	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I3W_RS14000	COG4715	Zinc finger, swim domain protein
I3W_RS14005	COG4808	Protein conserved in bacteria
I3W_RS14010	COG4807	Protein conserved in bacteria
I3W_RS14015	COG3279	Response regulator of the LytR AlgR family
I3W_RS14020	COG3275	phosphorelay sensor kinase activity
I3W_RS14045	COG5301	cellulose 1,4-beta-cellobiosidase activity
I3W_RS14150	COG4220	transposase activity
I3W_RS14165	COG3646	Phage regulatory protein
I3W_RS14180	COG3772	lysozyme
I3W_RS14260	COG1403	HNH endonuclease
I3W_RS14270	COG0305	Participates in initiation and elongation during chromosome replication
I3W_RS14275	COG1484	DNA-dependent DNA replication
I3W_RS14280	COG1802	Transcriptional regulator
I3W_RS14280	COG4626	Terminase
I3W_RS14290	COG3646	Phage regulatory protein
I3W_RS14310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I3W_RS14360	COG0582	viral genome integration into host DNA
I3W_RS14365	COG0789	Transcriptional regulator
I3W_RS14375	COG1174	glycine betaine transport
I3W_RS14380	COG1125	glycine betaine transport
I3W_RS14385	COG1174	glycine betaine transport
I3W_RS14395	COG1472	Belongs to the glycosyl hydrolase 3 family
I3W_RS14400	COG0277	FAD linked oxidase domain protein
I3W_RS14405	COG1686	Belongs to the peptidase S11 family
I3W_RS14415	COG0586	Pfam SNARE associated Golgi protein
I3W_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS14445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3W_RS14455	COG1346	cytolysis
I3W_RS14465	COG2949	membrane
I3W_RS14475	COG0493	'glutamate synthase
I3W_RS14480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3W_RS14480	COG0167	dihydroorotate dehydrogenase activity
I3W_RS14485	COG4211	Belongs to the binding-protein-dependent transport system permease family
I3W_RS14490	COG1129	ABC transporter
I3W_RS14495	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS14500	COG1609	Transcriptional regulator
I3W_RS14510	COG2311	Membrane
I3W_RS14535	COG4771	TonB-dependent receptor
I3W_RS14545	COG0833	amino acid
I3W_RS14555	COG0583	DNA-binding transcription factor activity
I3W_RS14560	COG2855	membrane
I3W_RS14570	COG1522	sequence-specific DNA binding
I3W_RS14570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS14575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3W_RS14585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3W_RS14590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3W_RS14595	COG2313	pseudouridylate synthase activity
I3W_RS14600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS14605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I3W_RS14605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS14605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS14610	COG1105	Belongs to the carbohydrate kinase PfkB family
I3W_RS14615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS14615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS14620	COG2814	Major facilitator Superfamily
I3W_RS14635	COG0246	Mannitol dehydrogenase
I3W_RS14640	COG0523	cobalamin synthesis protein
I3W_RS14645	COG0671	phosphoesterase, PA-phosphatase related
I3W_RS14650	COG0791	NLP P60 protein
I3W_RS14655	COG2200	EAL domain
I3W_RS14660	COG4166	transmembrane transport
I3W_RS14665	COG4174	ABC transporter (Permease)
I3W_RS14670	COG4239	(ABC) transporter, permease
I3W_RS14675	COG4172	Belongs to the ABC transporter superfamily
I3W_RS14690	COG2814	Major facilitator Superfamily
I3W_RS14695	COG1187	pseudouridine synthase activity
I3W_RS14705	COG1061	Type III restriction enzyme res subunit
I3W_RS14725	COG3083	sulfuric ester hydrolase activity
I3W_RS14745	COG2197	response regulator
I3W_RS14750	COG3088	subunit of a heme lyase
I3W_RS14750	COG4235	cytochrome complex assembly
I3W_RS14755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3W_RS14760	COG1138	Cytochrome C-type biogenesis protein
I3W_RS14770	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3W_RS14775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3W_RS14780	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3W_RS14785	COG4133	protoheme IX ABC transporter activity
I3W_RS14790	COG3005	denitrification pathway
I3W_RS14795	COG3043	anaerobic respiration
I3W_RS14800	COG0348	domain, Protein
I3W_RS14805	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS14815	COG3062	negative regulation of establishment of protein localization
I3W_RS14820	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS14820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS14840	COG4615	Cyclic peptide transporter
I3W_RS14845	COG3145	DNA-N1-methyladenine dioxygenase activity
I3W_RS14850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3W_RS14850	COG2169	Transcriptional regulator
I3W_RS14855	COG1477	protein flavinylation
I3W_RS14860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I3W_RS14875	COG0642	Histidine kinase
I3W_RS14875	COG2198	Histidine kinase
I3W_RS14880	COG2197	response regulator
I3W_RS14885	COG2205	protein histidine kinase activity
I3W_RS14885	COG0784	Response regulator, receiver
I3W_RS14890	COG4676	Protein conserved in bacteria
I3W_RS14895	COG5445	Predicted secreted protein (DUF2300)
I3W_RS14900	COG2373	Large extracellular alpha-helical protein
I3W_RS14905	COG3234	Protein of unknown function (DUF1175)
I3W_RS14910	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I3W_RS14915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3W_RS14930	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS14935	COG3468	outer membrane autotransporter barrel domain protein
I3W_RS14945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3W_RS14950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3W_RS14955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3W_RS14960	COG3642	lipopolysaccharide core region biosynthetic process
I3W_RS14965	COG0583	DNA-binding transcription factor activity
I3W_RS14970	COG0584	glycerophosphoryl diester phosphodiesterase
I3W_RS14975	COG2271	Major facilitator Superfamily
I3W_RS14980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3W_RS14990	COG0247	lactate metabolic process
I3W_RS14995	COG5464	transposase or invertase
I3W_RS15065	COG0318	PFAM AMP-dependent synthetase and ligase
I3W_RS15075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3W_RS15090	COG1169	isochorismate synthase
I3W_RS15095	COG4575	ribosome binding
I3W_RS15100	COG2153	protein acetylation
I3W_RS15130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3W_RS15135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3W_RS15145	COG0839	Belongs to the complex I subunit 6 family
I3W_RS15160	COG1034	ATP synthesis coupled electron transport
I3W_RS15165	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3W_RS15170	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I3W_RS15190	COG0583	DNA-binding transcription factor activity
I3W_RS15200	COG0436	Aminotransferase
I3W_RS15210	COG0490	domain, Protein
I3W_RS15210	COG0471	metal ion transport
I3W_RS15215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3W_RS15230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3W_RS15235	COG0280	phosphate acetyltransferase
I3W_RS15235	COG0857	belongs to the CobB CobQ family
I3W_RS15240	COG1288	antiporter activity
I3W_RS15245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I3W_RS15250	COG0622	Phosphoesterase
I3W_RS15255	COG0625	glutathione transferase activity
I3W_RS15260	COG0625	glutathione transferase activity
I3W_RS15265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3W_RS15270	COG1090	epimerase
I3W_RS15275	COG5464	transposase or invertase
I3W_RS15280	COG4598	ABC transporter
I3W_RS15285	COG4160	amino acid transport
I3W_RS15290	COG4215	(ABC) transporter
I3W_RS15295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS15300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS15305	COG0163	prenyltransferase activity
I3W_RS15310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I3W_RS15315	COG1286	toxin biosynthetic process
I3W_RS15320	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I3W_RS15325	COG0285	dihydrofolate synthase activity
I3W_RS15335	COG0586	Pfam SNARE associated Golgi protein
I3W_RS15345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3W_RS15360	COG2814	Major facilitator Superfamily
I3W_RS15370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3W_RS15385	COG3101	peptidyl-lysine hydroxylation
I3W_RS15390	COG0730	response to heat
I3W_RS15420	COG3539	Fimbrial protein
I3W_RS15425	COG3539	Fimbrial protein
I3W_RS15430	COG3539	Fimbrial protein
I3W_RS15435	COG3121	Chaperone
I3W_RS15440	COG3188	usher protein
I3W_RS15445	COG3539	Fimbrial protein
I3W_RS15450	COG2062	phosphohistidine phosphatase, SixA
I3W_RS15465	COG3691	Protein conserved in bacteria
I3W_RS15475	COG2067	long-chain fatty acid transport protein
I3W_RS15490	COG2853	Lipoprotein
I3W_RS15500	COG2116	formate transmembrane transporter activity
I3W_RS15540	COG0477	Major facilitator Superfamily
I3W_RS15545	COG1566	PFAM secretion protein HlyD family protein
I3W_RS15550	COG2197	response regulator
I3W_RS15555	COG2205	protein histidine kinase activity
I3W_RS15555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS15555	COG0784	Response regulator, receiver
I3W_RS15555	COG2198	Histidine kinase
I3W_RS15560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3W_RS15565	COG0679	Auxin Efflux Carrier
I3W_RS15570	COG0028	Belongs to the TPP enzyme family
I3W_RS15600	COG1560	Kdo2-lipid A biosynthetic process
I3W_RS15610	COG0436	Aminotransferase
I3W_RS15615	COG3275	phosphorelay sensor kinase activity
I3W_RS15620	COG3279	Response regulator of the LytR AlgR family
I3W_RS15625	COG2207	Transcriptional regulator
I3W_RS15635	COG1363	Peptidase, m42
I3W_RS15640	COG0006	proline dipeptidase activity
I3W_RS15645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS15650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS15675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3W_RS15680	COG2200	EAL domain
I3W_RS15680	COG2199	diguanylate cyclase activity
I3W_RS15695	COG3415	Transposase
I3W_RS15700	COG3415	Transposase
I3W_RS15735	COG0583	DNA-binding transcription factor activity
I3W_RS15745	COG2211	Major facilitator Superfamily
I3W_RS15750	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3W_RS15760	COG0583	DNA-binding transcription factor activity
I3W_RS15765	COG0385	Bile acid
I3W_RS15770	COG3530	Putative quorum-sensing-regulated virulence factor
I3W_RS15790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3W_RS15795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS15800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3W_RS15805	COG2190	(PTS) system
I3W_RS15820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3W_RS15825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3W_RS15830	COG4208	sulfate ABC transporter
I3W_RS15835	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I3W_RS15840	COG4150	thiosulfate binding
I3W_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS15860	COG1263	PTS System
I3W_RS15860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS15865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3W_RS15870	COG2837	iron assimilation
I3W_RS15890	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3W_RS15900	COG2207	Transcriptional regulator
I3W_RS15905	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3W_RS15910	COG4816	utilization protein
I3W_RS15920	COG4303	Ethanolamine ammonia lyase large subunit
I3W_RS15925	COG0582	viral genome integration into host DNA
I3W_RS15995	COG4819	ethanolamine utilization protein
I3W_RS16000	COG3192	ethanolamine utilization protein
I3W_RS16005	COG1454	alcohol dehydrogenase
I3W_RS16010	COG4820	ethanolamine utilization protein (EutJ)
I3W_RS16020	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I3W_RS16025	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I3W_RS16030	COG0280	phosphate acetyltransferase
I3W_RS16035	COG4812	Cobalamin adenosyltransferase
I3W_RS16040	COG4766	ethanolamine catabolic process
I3W_RS16045	COG4917	ethanolamine utilization protein
I3W_RS16050	COG4810	utilization protein
I3W_RS16060	COG0281	malic enzyme
I3W_RS16060	COG0280	phosphate acetyltransferase
I3W_RS16065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3W_RS16070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3W_RS16075	COG5342	invasion associated locus B
I3W_RS16085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS16085	COG0493	'glutamate synthase
I3W_RS16090	COG3850	Histidine kinase
I3W_RS16095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3W_RS16110	COG1393	Belongs to the ArsC family
I3W_RS16125	COG0400	carboxylic ester hydrolase activity
I3W_RS16130	COG1444	tRNA N-acetyltransferase activity
I3W_RS16135	COG2321	neutral zinc metallopeptidase
I3W_RS16155	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I3W_RS16165	COG2716	regulation of RNA biosynthetic process
I3W_RS16170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I3W_RS16175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS16185	COG0650	Formate hydrogenlyase subunit 4
I3W_RS16195	COG4237	Hydrogenase 4 membrane
I3W_RS16200	COG0651	ATP synthesis coupled electron transport
I3W_RS16205	COG3261	NADH dehydrogenase
I3W_RS16205	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I3W_RS16210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3W_RS16225	COG3604	Transcriptional regulator
I3W_RS16230	COG2116	formate transmembrane transporter activity
I3W_RS16240	COG0628	permease
I3W_RS16245	COG4783	chaperone-mediated protein folding
I3W_RS16250	COG1393	Belongs to the ArsC family
I3W_RS16260	COG2233	PERMEase
I3W_RS16280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I3W_RS16285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3W_RS16290	COG0248	Ppx GppA phosphatase
I3W_RS16295	COG2200	EAL domain
I3W_RS16315	COG3133	Outer membrane lipoprotein
I3W_RS16375	COG3846	protein secretion by the type IV secretion system
I3W_RS16415	COG0582	viral genome integration into host DNA
I3W_RS16425	COG0517	IMP dehydrogenase activity
I3W_RS16425	COG0516	GMP reductase activity
I3W_RS16435	COG1645	bacterial-type flagellum-dependent swarming motility
I3W_RS16450	COG2976	Protein conserved in bacteria
I3W_RS16485	COG4953	penicillin-binding protein 1C
I3W_RS16490	COG2373	Large extracellular alpha-helical protein
I3W_RS16495	COG2897	thiosulfate sulfurtransferase activity
I3W_RS16510	COG2975	iron-sulfur cluster assembly
I3W_RS16515	COG0633	Ferredoxin
I3W_RS16535	COG0822	iron-sulfur transferase activity
I3W_RS16555	COG0483	inositol monophosphate 1-phosphatase activity
I3W_RS16560	COG1073	alpha beta
I3W_RS16565	COG3711	transcriptional antiterminator
I3W_RS16570	COG2814	Major facilitator Superfamily
I3W_RS16575	COG0583	DNA-binding transcription factor activity
I3W_RS16580	COG4638	Rieske (2fe-2S)
I3W_RS16605	COG2259	Doxx family
I3W_RS16610	COG2017	converts alpha-aldose to the beta-anomer
I3W_RS16615	COG1063	alcohol dehydrogenase
I3W_RS16620	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS16625	COG1129	ABC transporter
I3W_RS16630	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS16635	COG0457	Tetratricopeptide repeat
I3W_RS16640	COG1940	carbohydrate kinase activity
I3W_RS16650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3W_RS16650	COG1017	nitric oxide dioxygenase activity
I3W_RS16655	COG0347	Belongs to the P(II) protein family
I3W_RS16660	COG2204	response regulator
I3W_RS16665	COG3170	Tfp pilus assembly protein FimV
I3W_RS16670	COG2205	protein histidine kinase activity
I3W_RS16695	COG0560	Phosphoserine phosphatase
I3W_RS16700	COG1737	Transcriptional regulator
I3W_RS16705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS16730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I3W_RS16755	COG0681	Belongs to the peptidase S26 family
I3W_RS16765	COG3086	response to oxidative stress
I3W_RS16770	COG3026	antisigma factor binding
I3W_RS16775	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I3W_RS16780	COG1595	DNA-templated transcription, initiation
I3W_RS16785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3W_RS16795	COG0513	Belongs to the DEAD box helicase family
I3W_RS16800	COG0583	DNA-binding transcription factor activity
I3W_RS16820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3W_RS16830	COG3118	belongs to the thioredoxin family
I3W_RS16835	COG3148	PFAM DTW domain containing protein
I3W_RS16840	COG0045	succinate-CoA ligase (ADP-forming) activity
I3W_RS16840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3W_RS16840	COG1042	CoA-binding domain protein
I3W_RS16845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3W_RS16850	COG5544	Lipoprotein
I3W_RS16855	COG0477	Major facilitator Superfamily
I3W_RS16885	COG0542	response to heat
I3W_RS16890	COG1496	oxidoreductase activity
I3W_RS16895	COG0564	pseudouridine synthase activity
I3W_RS16900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3W_RS16910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3W_RS16920	COG0077	Prephenate dehydratase
I3W_RS16920	COG1605	Chorismate mutase
I3W_RS16925	COG0287	Prephenate dehydrogenase
I3W_RS16925	COG1605	Chorismate mutase
I3W_RS16930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3W_RS16945	COG2199	diguanylate cyclase activity
I3W_RS16950	COG2885	chlorophyll binding
I3W_RS16975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I3W_RS16980	COG4137	Cytochrome C assembly protein
I3W_RS16985	COG4536	flavin adenine dinucleotide binding
I3W_RS17010	COG0497	DNA recombination
I3W_RS17015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3W_RS17025	COG2867	negative regulation of translational initiation
I3W_RS17040	COG0582	viral genome integration into host DNA
I3W_RS17070	COG0579	oxidoreductase
I3W_RS17075	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS17080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3W_RS17085	COG1113	amino acid transport
I3W_RS17090	COG1802	Transcriptional regulator
I3W_RS17095	COG1652	LysM domain
I3W_RS17100	COG0401	homolog of Blt101
I3W_RS17105	COG0640	Transcriptional regulator
I3W_RS17110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3W_RS17115	COG2916	Histone family protein nucleoid-structuring protein H-NS
I3W_RS17130	COG4575	ribosome binding
I3W_RS17135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3W_RS17145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3W_RS17150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3W_RS17155	COG4175	Glycine betaine
I3W_RS17160	COG4176	ABC-type proline glycine betaine transport system permease component
I3W_RS17165	COG2113	Glycine betaine
I3W_RS17170	COG2814	Major facilitator Superfamily
I3W_RS17175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3W_RS17185	COG1846	Transcriptional regulator
I3W_RS17190	COG1566	PFAM secretion protein HlyD family protein
I3W_RS17195	COG2814	Major facilitator Superfamily
I3W_RS17210	COG1238	metal cluster binding
I3W_RS17215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3W_RS17245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I3W_RS17265	COG1546	Belongs to the CinA family
I3W_RS17270	COG2951	lytic endotransglycosylase activity
I3W_RS17275	COG3730	PTS system glucitol sorbitol-specific
I3W_RS17280	COG3732	PTS system glucitol sorbitol-specific
I3W_RS17285	COG3731	PTS system glucitol sorbitol-specific IIA component
I3W_RS17290	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS17295	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS17300	COG1349	DNA-binding transcription factor activity
I3W_RS17325	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I3W_RS17330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS17335	COG1609	Transcriptional regulator
I3W_RS17340	COG1263	PTS System
I3W_RS17340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS17345	COG2723	6-phospho-beta-galactosidase activity
I3W_RS17350	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS17360	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3W_RS17370	COG3260	NADH ubiquinone oxidoreductase 20
I3W_RS17375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3W_RS17380	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I3W_RS17380	COG3261	NADH dehydrogenase
I3W_RS17385	COG0650	Formate hydrogenlyase subunit 4
I3W_RS17390	COG0651	ATP synthesis coupled electron transport
I3W_RS17395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS17405	COG0375	protein maturation
I3W_RS17410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I3W_RS17415	COG0298	carbon dioxide binding
I3W_RS17420	COG0409	Hydrogenase expression formation protein
I3W_RS17425	COG0309	Hydrogenase expression formation protein (HypE)
I3W_RS17430	COG3604	Transcriptional regulator
I3W_RS17450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I3W_RS17455	COG1349	DNA-binding transcription factor activity
I3W_RS17460	COG2084	Dehydrogenase
I3W_RS17465	COG3395	kinase activity
I3W_RS17470	COG0235	Class ii aldolase
I3W_RS17475	COG3622	Belongs to the hyi family
I3W_RS17480	COG2610	gluconate transmembrane transporter activity
I3W_RS17490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3W_RS17505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3W_RS17510	COG4942	peptidase
I3W_RS17510	COG1388	LysM domain
I3W_RS17565	COG2234	aminopeptidase activity
I3W_RS17570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3W_RS17575	COG1518	maintenance of DNA repeat elements
I3W_RS17590	COG1857	crispr-associated protein
I3W_RS17605	COG1203	CRISPR-associated helicase, Cas3
I3W_RS17635	COG0720	synthase
I3W_RS17640	COG0644	oxidoreductase
I3W_RS17645	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I3W_RS17650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3W_RS17655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3W_RS17660	COG2086	electron transfer activity
I3W_RS17665	COG0477	Major facilitator Superfamily
I3W_RS17670	COG0277	FAD linked oxidase domain protein
I3W_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS17680	COG2223	nitrite transmembrane transporter activity
I3W_RS17685	COG1070	Carbohydrate kinase
I3W_RS17690	COG0602	queuosine metabolic process
I3W_RS17700	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I3W_RS17715	COG3956	TIGRFAM MazG family protein
I3W_RS17720	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3W_RS17725	COG2336	PFAM SpoVT AbrB
I3W_RS17730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3W_RS17735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3W_RS17740	COG4999	Histidine kinase
I3W_RS17740	COG3850	Histidine kinase
I3W_RS17740	COG3437	response regulator, receiver
I3W_RS17740	COG2205	protein histidine kinase activity
I3W_RS17745	COG4948	Mandelate Racemase Muconate Lactonizing
I3W_RS17750	COG4948	Mandelate Racemase Muconate Lactonizing
I3W_RS17755	COG2271	Major facilitator Superfamily
I3W_RS17760	COG0716	FMN binding
I3W_RS17765	COG0564	pseudouridine synthase activity
I3W_RS17770	COG3098	single-species biofilm formation
I3W_RS17785	COG1611	Belongs to the LOG family
I3W_RS17790	COG0814	amino acid
I3W_RS17795	COG1760	l-serine dehydratase
I3W_RS17805	COG1454	alcohol dehydrogenase
I3W_RS17810	COG0235	Class ii aldolase
I3W_RS17815	COG0738	Major facilitator superfamily
I3W_RS17825	COG1070	Carbohydrate kinase
I3W_RS17835	COG1349	DNA-binding transcription factor activity
I3W_RS17845	COG2363	Small membrane protein
I3W_RS17850	COG0583	DNA-binding transcription factor activity
I3W_RS17860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3W_RS17865	COG2166	iron-sulfur cluster assembly
I3W_RS17870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I3W_RS17875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I3W_RS17900	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3W_RS17910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3W_RS17910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3W_RS17915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3W_RS17920	COG1074	ATP-dependent DNA helicase activity
I3W_RS17925	COG1025	Belongs to the peptidase M16 family
I3W_RS17930	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3W_RS17935	COG4967	type IV pilus modification protein PilV
I3W_RS17945	COG4795	General secretion pathway protein
I3W_RS17950	COG2165	general secretion pathway protein
I3W_RS17965	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I3W_RS17980	COG0861	Integral membrane protein TerC family
I3W_RS17990	COG0667	Aldo Keto reductase
I3W_RS18005	COG1609	Transcriptional regulator
I3W_RS18015	COG0583	DNA-binding transcription factor activity
I3W_RS18020	COG1794	racemase activity, acting on amino acids and derivatives
I3W_RS18025	COG2814	Major facilitator Superfamily
I3W_RS18030	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS18040	COG0183	Belongs to the thiolase family
I3W_RS18045	COG0814	amino acid
I3W_RS18050	COG2771	luxR family
I3W_RS18055	COG3710	Transcriptional regulator
I3W_RS18080	COG0457	Tetratricopeptide repeat
I3W_RS18085	COG0457	Tetratricopeptide repeat
I3W_RS18085	COG3710	Transcriptional regulator
I3W_RS18100	COG2197	response regulator
I3W_RS18105	COG2197	response regulator
I3W_RS18195	COG3387	PFAM Glycoside hydrolase 15-related
I3W_RS18205	COG4942	peptidase
I3W_RS18215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3W_RS18220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3W_RS18225	COG2080	2 iron, 2 sulfur cluster binding
I3W_RS18230	COG3829	transcription factor binding
I3W_RS18235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3W_RS18240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3W_RS18245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3W_RS18255	COG0549	Belongs to the carbamate kinase family
I3W_RS18260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3W_RS18260	COG3608	succinylglutamate desuccinylase aspartoacylase
I3W_RS18265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I3W_RS18270	COG2068	MobA-Related Protein
I3W_RS18275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS18275	COG0493	'glutamate synthase
I3W_RS18280	COG0402	S-adenosylhomocysteine deaminase activity
I3W_RS18285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I3W_RS18290	COG2080	2 iron, 2 sulfur cluster binding
I3W_RS18290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3W_RS18295	COG2233	PERMEase
I3W_RS18300	COG0402	S-adenosylhomocysteine deaminase activity
I3W_RS18305	COG2252	PERMEase
I3W_RS18310	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS18315	COG0493	'glutamate synthase
I3W_RS18315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS18325	COG2233	PERMEase
I3W_RS18350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I3W_RS18355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3W_RS18360	COG4974	Belongs to the 'phage' integrase family
I3W_RS18365	COG0716	FMN binding
I3W_RS18375	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I3W_RS18385	COG1272	protein, Hemolysin III
I3W_RS18395	COG2723	6-phospho-beta-galactosidase activity
I3W_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS18420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3W_RS18425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3W_RS18430	COG0006	proline dipeptidase activity
I3W_RS18455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3W_RS18475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3W_RS18495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3W_RS18495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I3W_RS18500	COG1703	isobutyryl-CoA mutase activity
I3W_RS18505	COG1024	Enoyl-CoA hydratase
I3W_RS18510	COG0427	acetyl-CoA hydrolase
I3W_RS18515	COG0583	DNA-binding transcription factor activity
I3W_RS18520	COG2968	Membrane
I3W_RS18530	COG0668	transmembrane transport
I3W_RS18540	COG0191	fructose-bisphosphate aldolase activity
I3W_RS18575	COG1122	ATPase activity
I3W_RS18580	COG1122	ATPase activity
I3W_RS18585	COG1072	(Pantothenic acid kinase))
I3W_RS18595	COG1494	fructose-1,6-bisphosphatase
I3W_RS18600	COG1063	alcohol dehydrogenase
I3W_RS18605	COG2213	PTS system mannitol-specific
I3W_RS18610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS18615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3W_RS18620	COG0501	Belongs to the peptidase M48B family
I3W_RS18635	COG3716	PTS system mannose fructose sorbose family IID component
I3W_RS18640	COG3715	PTS system
I3W_RS18645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS18645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS18670	COG1166	arginine decarboxylase activity
I3W_RS18695	COG2814	Major facilitator Superfamily
I3W_RS18705	COG2356	endonuclease I
I3W_RS18710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3W_RS18715	COG0189	ligase activity
I3W_RS18730	COG2805	Type II/IV secretion system protein
I3W_RS18735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3W_RS18740	COG0762	integral membrane protein
I3W_RS18755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3W_RS18765	COG0252	asparaginase activity
I3W_RS18775	COG3171	Protein conserved in bacteria
I3W_RS18790	COG1194	a g-specific adenine glycosylase
I3W_RS18805	COG2211	Major facilitator Superfamily
I3W_RS18810	COG1982	Orn Lys Arg decarboxylase major
I3W_RS18820	COG1811	Na channel or pump
I3W_RS18830	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I3W_RS18860	COG2165	general secretion pathway protein
I3W_RS18865	COG1459	type II secretion system
I3W_RS18870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3W_RS18895	COG3064	Membrane
I3W_RS18905	COG1620	l-lactate permease
I3W_RS18910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3W_RS18920	COG0277	FAD linked oxidase domain protein
I3W_RS18925	COG0277	FAD linked oxidase domain protein
I3W_RS18930	COG2186	Transcriptional regulator
I3W_RS18935	COG0456	acetyltransferase
I3W_RS18945	COG0318	PFAM AMP-dependent synthetase and ligase
I3W_RS18955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3W_RS18960	COG0156	8-amino-7-oxononanoate synthase activity
I3W_RS18970	COG0795	lipopolysaccharide-transporting ATPase activity
I3W_RS18975	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3W_RS18985	COG2244	polysaccharide biosynthetic process
I3W_RS18990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3W_RS18995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3W_RS19000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I3W_RS19005	COG0306	phosphate transporter
I3W_RS19010	COG0754	glutathionylspermidine amidase activity
I3W_RS19015	COG0625	glutathione transferase activity
I3W_RS19025	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS19030	COG0298	carbon dioxide binding
I3W_RS19040	COG1773	rubredoxin
I3W_RS19045	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I3W_RS19050	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I3W_RS19055	COG5557	Pfam Polysulphide reductase, NrfD
I3W_RS19060	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS19065	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I3W_RS19085	COG0667	Aldo Keto reductase
I3W_RS19095	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS19100	COG0848	biopolymer transport protein
I3W_RS19105	COG0811	peptide transport
I3W_RS19115	COG0626	cystathionine gamma-synthase activity
I3W_RS19120	COG0586	Pfam SNARE associated Golgi protein
I3W_RS19125	COG2207	Transcriptional regulator
I3W_RS19130	COG1979	alcohol dehydrogenase
I3W_RS19135	COG0656	L-ascorbic acid biosynthetic process
I3W_RS19145	COG4238	major outer membrane lipoprotein
I3W_RS19150	COG1032	radical SAM domain protein
I3W_RS19155	COG2132	Multicopper oxidase
I3W_RS19160	COG0204	Acyl-transferase
I3W_RS19165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3W_RS19175	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3W_RS19180	COG3111	PFAM Bacterial OB fold (BOF) protein
I3W_RS19185	COG0745	RESPONSE REGULATOR receiver
I3W_RS19190	COG0642	Histidine kinase
I3W_RS19200	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3W_RS19205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I3W_RS19210	COG0187	DNA topoisomerase II activity
I3W_RS19215	COG3150	esterase
I3W_RS19220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3W_RS19225	COG3151	Protein conserved in bacteria
I3W_RS19230	COG0494	nUDIX hydrolase
I3W_RS19235	COG1538	Outer membrane efflux protein
I3W_RS19250	COG0754	glutathionylspermidine amidase activity
I3W_RS19255	COG3384	dioxygenase
I3W_RS19275	COG2960	long-chain fatty acid transporting porin activity
I3W_RS19280	COG3539	Fimbrial protein
I3W_RS19285	COG3188	usher protein
I3W_RS19290	COG3121	Chaperone
I3W_RS19295	COG3539	Fimbrial protein
I3W_RS19305	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3W_RS19310	COG2268	Band 7 protein
I3W_RS19345	COG3025	triphosphatase activity
I3W_RS19355	COG4991	sh3 domain protein
I3W_RS19370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3W_RS19380	COG0583	DNA-binding transcription factor activity
I3W_RS19390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3W_RS19395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3W_RS19400	COG0471	metal ion transport
I3W_RS19415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I3W_RS19420	COG0358	DNA primase activity
I3W_RS19430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3W_RS19475	COG2003	Belongs to the UPF0758 family
I3W_RS19495	COG3468	outer membrane autotransporter barrel domain protein
I3W_RS19530	COG3385	transposase activity
I3W_RS19580	COG1358	cellular component organization or biogenesis
I3W_RS19620	COG4372	Transposase
I3W_RS19625	COG3436	PFAM IS66 Orf2 family protein
I3W_RS19640	COG3210	domain, Protein
I3W_RS19645	COG2994	toxin metabolic process
I3W_RS19650	COG2831	hemolysin activation secretion protein
I3W_RS19675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3W_RS19705	COG2375	cellular response to nickel ion
I3W_RS19715	COG1695	Transcriptional regulator
I3W_RS19720	COG0840	transmembrane signaling receptor activity
I3W_RS19735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3W_RS19745	COG1609	Transcriptional regulator
I3W_RS19750	COG3250	beta-galactosidase activity
I3W_RS19755	COG2731	YhcH YjgK YiaL family protein
I3W_RS19760	COG0531	amino acid
I3W_RS19770	COG3408	Glycogen debranching enzyme
I3W_RS19770	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I3W_RS19775	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3W_RS19775	COG1902	pentaerythritol trinitrate reductase activity
I3W_RS19780	COG5499	transcription regulator containing HTH domain
I3W_RS19785	COG4680	protein conserved in bacteria
I3W_RS19795	COG1451	nucleotide metabolic process
I3W_RS19800	COG2949	membrane
I3W_RS19805	COG0673	inositol 2-dehydrogenase activity
I3W_RS19810	COG0861	Integral membrane protein TerC family
I3W_RS19815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I3W_RS19825	COG2721	sulfolactate sulfo-lyase activity
I3W_RS19835	COG2271	Major facilitator Superfamily
I3W_RS19865	COG2186	Transcriptional regulator
I3W_RS19870	COG0586	Pfam SNARE associated Golgi protein
I3W_RS19880	COG1422	Protein of unknown function (DUF1090)
I3W_RS19885	COG4575	ribosome binding
I3W_RS19890	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I3W_RS19900	COG2259	Doxx family
I3W_RS19905	COG0435	Glutathione S-transferase
I3W_RS19910	COG3152	Membrane
I3W_RS19915	COG3152	Membrane
I3W_RS19925	COG0583	DNA-binding transcription factor activity
I3W_RS19930	COG1741	Belongs to the pirin family
I3W_RS19945	COG0814	amino acid
I3W_RS19955	COG1760	l-serine dehydratase
I3W_RS19960	COG0251	oxidation-reduction process
I3W_RS19965	COG1882	Formate acetyltransferase
I3W_RS19970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3W_RS19980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3W_RS19990	COG0583	DNA-binding transcription factor activity
I3W_RS20015	COG1929	Belongs to the glycerate kinase type-1 family
I3W_RS20020	COG2084	Dehydrogenase
I3W_RS20030	COG2271	Major facilitator Superfamily
I3W_RS20035	COG2721	sulfolactate sulfo-lyase activity
I3W_RS20040	COG2002	toxin-antitoxin pair type II binding
I3W_RS20050	COG1349	DNA-binding transcription factor activity
I3W_RS20065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS20075	COG3716	PTS system mannose fructose sorbose family IID component
I3W_RS20080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS20085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3W_RS20090	COG2222	sugar isomerase
I3W_RS20100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS20105	COG3715	PTS system
I3W_RS20110	COG3716	PTS system mannose fructose sorbose family IID component
I3W_RS20115	COG0363	glucosamine-6-phosphate deaminase activity
I3W_RS20120	COG3539	Fimbrial protein
I3W_RS20125	COG3121	Chaperone
I3W_RS20130	COG3188	usher protein
I3W_RS20135	COG3539	Fimbrial protein
I3W_RS20140	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I3W_RS20160	COG2823	Periplasmic or secreted lipoprotein
I3W_RS20165	COG0701	Predicted permease
I3W_RS20170	COG0702	epimerase
I3W_RS20175	COG0693	protein deglycase activity
I3W_RS20190	COG3153	acetyltransferase
I3W_RS20195	COG3154	lipid carrier protein
I3W_RS20200	COG0826	peptidase U32
I3W_RS20205	COG0826	peptidase U32
I3W_RS20210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3W_RS20215	COG0814	amino acid
I3W_RS20220	COG0513	Belongs to the DEAD box helicase family
I3W_RS20260	COG0195	Participates in both transcription termination and antitermination
I3W_RS20290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3W_RS20300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3W_RS20305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3W_RS20315	COG1534	Rna-binding protein
I3W_RS20320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3W_RS20325	COG2027	D-alanyl-D-alanine carboxypeptidase
I3W_RS20335	COG0697	spore germination
I3W_RS20350	COG0142	geranyltranstransferase activity
I3W_RS20355	COG3423	Transcriptional regulator
I3W_RS20365	COG5007	Belongs to the BolA IbaG family
I3W_RS20370	COG3113	response to antibiotic
I3W_RS20375	COG2854	intermembrane phospholipid transfer
I3W_RS20380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3W_RS20385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3W_RS20390	COG1127	ABC transporter
I3W_RS20395	COG0530	calcium, potassium:sodium antiporter activity
I3W_RS20400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3W_RS20400	COG0517	IMP dehydrogenase activity
I3W_RS20405	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I3W_RS20410	COG3117	lipopolysaccharide transmembrane transporter activity
I3W_RS20415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I3W_RS20420	COG1137	ATPase activity
I3W_RS20425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I3W_RS20430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3W_RS20445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS20450	COG0515	serine threonine protein kinase
I3W_RS20460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I3W_RS20465	COG5002	protein histidine kinase activity
I3W_RS20465	COG0784	Response regulator, receiver
I3W_RS20465	COG2198	Histidine kinase
I3W_RS20470	COG1242	4 iron, 4 sulfur cluster binding
I3W_RS20485	COG0069	glutamate synthase activity
I3W_RS20485	COG0067	glutamate synthase
I3W_RS20485	COG0070	glutamate synthase
I3W_RS20490	COG0493	'glutamate synthase
I3W_RS20495	COG4804	nuclease activity
I3W_RS20500	COG2731	YhcH YjgK YiaL family protein
I3W_RS20535	COG3069	C4-dicarboxylate transmembrane transporter activity
I3W_RS20540	COG2969	positive regulation of protein catabolic process
I3W_RS20545	COG0625	glutathione transferase activity
I3W_RS20575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I3W_RS20580	COG3105	Protein conserved in bacteria
I3W_RS20585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3W_RS20590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3W_RS20610	COG2732	(Barnase) inhibitor
I3W_RS20630	COG0583	DNA-binding transcription factor activity
I3W_RS20635	COG0312	modulator of DNA gyrase
I3W_RS20640	COG3164	Protein of unknown function
I3W_RS20645	COG1530	ribonuclease E activity
I3W_RS20655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I3W_RS20660	COG1792	Involved in formation and maintenance of cell shape
I3W_RS20665	COG1077	Cell shape determining protein MreB Mrl
I3W_RS20680	COG2199	diguanylate cyclase activity
I3W_RS20680	COG2200	EAL domain
I3W_RS20685	COG0604	alcohol dehydrogenase
I3W_RS20695	COG0511	ligase activity, forming carbon-carbon bonds
I3W_RS20700	COG0439	Biotin carboxylase
I3W_RS20705	COG3924	membrane
I3W_RS20710	COG4145	pantothenate transmembrane transporter activity
I3W_RS20720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3W_RS20730	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I3W_RS20740	COG1309	transcriptional regulator
I3W_RS20750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS20755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3W_RS20770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3W_RS20775	COG4597	amino acid ABC transporter
I3W_RS20780	COG0765	amino acid transport
I3W_RS20785	COG1126	abc transporter atp-binding protein
I3W_RS20825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3W_RS20845	COG0551	DNA topoisomerase type I activity
I3W_RS20855	COG0758	DNA mediated transformation
I3W_RS20875	COG0569	domain protein
I3W_RS20885	COG3036	rescue of stalled ribosome
I3W_RS20890	COG0789	Transcriptional regulator
I3W_RS20930	COG0201	protein transport
I3W_RS21020	COG0089	rRNA binding
I3W_RS21100	COG2964	Protein conserved in bacteria
I3W_RS21105	COG0545	Peptidyl-prolyl cis-trans isomerase
I3W_RS21115	COG1047	Peptidyl-prolyl cis-trans
I3W_RS21120	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I3W_RS21140	COG0488	(ABC) transporter
I3W_RS21145	COG0429	hydrolase of the alpha beta-hydrolase fold
I3W_RS21155	COG3954	Phosphoribulokinase
I3W_RS21160	COG1765	OsmC-like protein
I3W_RS21170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3W_RS21175	COG1289	transmembrane transporter activity
I3W_RS21180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3W_RS21185	COG0512	Glutamine amidotransferase of anthranilate synthase
I3W_RS21190	COG2184	nucleotidyltransferase activity
I3W_RS21200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3W_RS21210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3W_RS21215	COG2146	nitrite reductase [NAD(P)H] activity
I3W_RS21220	COG2116	formate transmembrane transporter activity
I3W_RS21235	COG0531	amino acid
I3W_RS21240	COG2222	sugar isomerase
I3W_RS21250	COG1082	Xylose isomerase domain protein TIM barrel
I3W_RS21260	COG2188	Transcriptional regulator
I3W_RS21280	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I3W_RS21285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I3W_RS21290	COG3457	Alanine racemase
I3W_RS21300	COG2188	Transcriptional regulator
I3W_RS21305	COG0180	Tryptophanyl-tRNA synthetase
I3W_RS21315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3W_RS21320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I3W_RS21325	COG3266	domain, Protein
I3W_RS21345	COG4796	Type ii and iii secretion system protein
I3W_RS21360	COG3166	PFAM Fimbrial assembly family protein
I3W_RS21365	COG4972	Pilus assembly protein
I3W_RS21370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3W_RS21375	COG0494	nUDIX hydrolase
I3W_RS21385	COG1011	Hydrolase
I3W_RS21390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I3W_RS21400	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3W_RS21430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3W_RS21435	COG2183	response to ionizing radiation
I3W_RS21445	COG1918	ferrous iron import across plasma membrane
I3W_RS21450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I3W_RS21475	COG1040	competence protein
I3W_RS21485	COG2610	gluconate transmembrane transporter activity
I3W_RS21490	COG1640	4-alpha-glucanotransferase
I3W_RS21495	COG0058	SHG alpha-glucan phosphorylase activity
I3W_RS21510	COG1690	Belongs to the RtcB family
I3W_RS21515	COG4650	regulator
I3W_RS21520	COG1349	DNA-binding transcription factor activity
I3W_RS21535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3W_RS21555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3W_RS21560	COG0058	SHG alpha-glucan phosphorylase activity
I3W_RS21585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3W_RS21590	COG2095	MarC family integral membrane protein
I3W_RS21600	COG0514	ATP-dependent DNA helicase (RecQ)
I3W_RS21605	COG2610	gluconate transmembrane transporter activity
I3W_RS21610	COG3265	gluconokinase activity
I3W_RS21615	COG1609	Transcriptional regulator
I3W_RS21620	COG1741	Belongs to the pirin family
I3W_RS21635	COG1247	-acetyltransferase
I3W_RS21640	COG3157	Type VI secretion system effector, Hcp
I3W_RS21660	COG0405	Gamma-glutamyltransferase
I3W_RS21670	COG0584	glycerophosphoryl diester phosphodiesterase
I3W_RS21675	COG3842	ATPase activity
I3W_RS21685	COG1175	transmembrane transport
I3W_RS21690	COG1653	transport
I3W_RS21695	COG0410	ABC transporter
I3W_RS21700	COG0411	ABC transporter
I3W_RS21705	COG4177	L-phenylalanine transmembrane transporter activity
I3W_RS21710	COG0559	Belongs to the binding-protein-dependent transport system permease family
I3W_RS21715	COG0683	leucine binding
I3W_RS21720	COG0456	acetyltransferase
I3W_RS21725	COG0683	leucine binding
I3W_RS21730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3W_RS21735	COG2177	Part of the ABC transporter FtsEX involved in
I3W_RS21740	COG2884	Cell division ATP-binding protein ftsE
I3W_RS21745	COG0552	protein localization to endoplasmic reticulum
I3W_RS21750	COG0742	ribosomal rna small subunit methyltransferase
I3W_RS21755	COG3776	membrane
I3W_RS21765	COG3714	YhhN family
I3W_RS21780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I3W_RS21795	COG0628	permease
I3W_RS21800	COG2091	lysine biosynthetic process via aminoadipic acid
I3W_RS21805	COG0747	negative chemotaxis
I3W_RS21810	COG0601	transmembrane transport
I3W_RS21815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3W_RS21820	COG0444	Belongs to the ABC transporter superfamily
I3W_RS21845	COG0842	Transport permease protein
I3W_RS21850	COG1129	ABC transporter
I3W_RS21850	COG0842	Transport permease protein
I3W_RS21855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS21880	COG2081	HI0933 family
I3W_RS21885	COG0306	phosphate transporter
I3W_RS21895	COG0589	response to stress
I3W_RS21905	COG3104	oligopeptide transport
I3W_RS21915	COG0339	signal peptide processing
I3W_RS21920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I3W_RS21925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3W_RS21940	COG0640	Transcriptional regulator
I3W_RS21945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3W_RS21950	COG1393	Belongs to the ArsC family
I3W_RS21970	COG3065	identical protein binding
I3W_RS21980	COG2197	response regulator
I3W_RS21985	COG1285	pathogenesis
I3W_RS22000	COG3247	response to pH
I3W_RS22005	COG2771	luxR family
I3W_RS22015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3W_RS22020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3W_RS22030	COG2207	Transcriptional regulator
I3W_RS22040	COG0076	glutamate decarboxylase activity
I3W_RS22045	COG1858	cytochrome C peroxidase
I3W_RS22055	COG2197	response regulator
I3W_RS22060	COG0583	DNA-binding transcription factor activity
I3W_RS22065	COG1295	ribonuclease BN
I3W_RS22070	COG0477	Major facilitator Superfamily
I3W_RS22075	COG2982	Protein involved in outer membrane biogenesis
I3W_RS22080	COG2200	EAL domain
I3W_RS22095	COG0612	Peptidase, M16
I3W_RS22115	COG3118	belongs to the thioredoxin family
I3W_RS22115	COG0457	Tetratricopeptide repeat
I3W_RS22120	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I3W_RS22125	COG1215	transferase activity, transferring glycosyl groups
I3W_RS22155	COG2194	sulfuric ester hydrolase activity
I3W_RS22190	COG0814	amino acid
I3W_RS22195	COG4608	Belongs to the ABC transporter superfamily
I3W_RS22200	COG0444	Belongs to the ABC transporter superfamily
I3W_RS22205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3W_RS22210	COG0601	transmembrane transport
I3W_RS22215	COG0747	negative chemotaxis
I3W_RS22230	COG2194	sulfuric ester hydrolase activity
I3W_RS22260	COG2223	nitrite transmembrane transporter activity
I3W_RS22270	COG5571	outer membrane autotransporter
I3W_RS22275	COG2818	Glycosylase
I3W_RS22280	COG0456	acetyltransferase
I3W_RS22285	COG0243	molybdopterin cofactor binding
I3W_RS22290	COG2885	chlorophyll binding
I3W_RS22305	COG2944	sequence-specific DNA binding
I3W_RS22310	COG1278	Cold shock
I3W_RS22335	COG3274	enterobacterial common antigen metabolic process
I3W_RS22340	COG4682	membrane
I3W_RS22345	COG4682	membrane
I3W_RS22350	COG1070	Carbohydrate kinase
I3W_RS22360	COG4213	ABC transporter substrate-binding protein
I3W_RS22365	COG1129	ABC transporter
I3W_RS22370	COG4214	carbohydrate transport
I3W_RS22375	COG2207	Transcriptional regulator
I3W_RS22375	COG1609	Transcriptional regulator
I3W_RS22380	COG2992	FlgJ-related protein
I3W_RS22385	COG0366	Alpha amylase catalytic
I3W_RS22390	COG3977	Valine--pyruvate aminotransferase
I3W_RS22395	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I3W_RS22400	COG1414	Transcriptional regulator
I3W_RS22410	COG2731	YhcH YjgK YiaL family protein
I3W_RS22415	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3W_RS22420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I3W_RS22425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3W_RS22430	COG1070	Carbohydrate kinase
I3W_RS22435	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3W_RS22440	COG3623	hexulose-6-phosphate isomerase
I3W_RS22445	COG0235	Class ii aldolase
I3W_RS22455	COG3713	MltA-interacting MipA family protein
I3W_RS22460	COG0583	DNA-binding transcription factor activity
I3W_RS22465	COG1566	PFAM secretion protein HlyD family protein
I3W_RS22480	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS22485	COG1454	alcohol dehydrogenase
I3W_RS22490	COG3276	selenocysteine insertion sequence binding
I3W_RS22500	COG0625	glutathione transferase activity
I3W_RS22505	COG3209	COG3209 Rhs family protein
I3W_RS22520	COG3209	COG3209 Rhs family protein
I3W_RS22525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3W_RS22545	COG1566	PFAM secretion protein HlyD family protein
I3W_RS22555	COG2213	PTS system mannitol-specific
I3W_RS22555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS22565	COG3722	fumarate hydratase activity
I3W_RS22590	COG5295	Hep Hag repeat protein
I3W_RS22595	COG1620	l-lactate permease
I3W_RS22600	COG2186	Transcriptional regulator
I3W_RS22610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3W_RS22615	COG1045	serine acetyltransferase
I3W_RS22630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3W_RS22635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3W_RS22650	COG4942	peptidase
I3W_RS22655	COG2861	carbohydrate metabolic process
I3W_RS22660	COG1216	Glycosyl transferase, family 2
I3W_RS22670	COG0156	8-amino-7-oxononanoate synthase activity
I3W_RS22685	COG0859	PFAM glycosyl transferase family 9
I3W_RS22690	COG0859	PFAM glycosyl transferase family 9
I3W_RS22710	COG3642	lipopolysaccharide core region biosynthetic process
I3W_RS22720	COG0515	serine threonine protein kinase
I3W_RS22725	COG0438	transferase activity, transferring glycosyl groups
I3W_RS22730	COG0859	PFAM glycosyl transferase family 9
I3W_RS22735	COG1519	Transferase
I3W_RS22765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3W_RS22795	COG1561	YicC-like family, N-terminal region
I3W_RS22910	COG3645	SOS response
I3W_RS22915	COG2860	membrane
I3W_RS22925	COG0194	GDP metabolic process
I3W_RS22935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3W_RS22940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3W_RS22945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3W_RS22955	COG0786	glutamate:sodium symporter activity
I3W_RS22960	COG2233	PERMEase
I3W_RS22965	COG2982	Protein involved in outer membrane biogenesis
I3W_RS22970	COG1501	Belongs to the glycosyl hydrolase 31 family
I3W_RS22975	COG2211	Major facilitator Superfamily
I3W_RS22990	COG2814	Major facilitator Superfamily
I3W_RS22995	COG0697	spore germination
I3W_RS23000	COG1464	Belongs to the NlpA lipoprotein family
I3W_RS23030	COG2252	PERMEase
I3W_RS23040	COG2271	Major facilitator Superfamily
I3W_RS23045	COG2271	Major facilitator Superfamily
I3W_RS23050	COG3851	Histidine kinase
I3W_RS23055	COG2197	response regulator
I3W_RS23060	COG0440	acetolactate synthase activity
I3W_RS23065	COG0028	Belongs to the TPP enzyme family
I3W_RS23100	COG2814	Major facilitator Superfamily
I3W_RS23105	COG0641	radical SAM
I3W_RS23115	COG2149	membrane
I3W_RS23125	COG3119	arylsulfatase activity
I3W_RS23130	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3W_RS23135	COG2207	Transcriptional regulator
I3W_RS23150	COG2188	Transcriptional regulator
I3W_RS23170	COG5645	(Lipo)protein
I3W_RS23175	COG0823	Involved in the tonB-independent uptake of proteins
I3W_RS23185	COG2271	Major facilitator Superfamily
I3W_RS23195	COG0800	Aldolase
I3W_RS23200	COG3734	2-keto-3-deoxy-galactonokinase
I3W_RS23205	COG2186	Transcriptional regulator
I3W_RS23215	COG0561	phosphatase activity
I3W_RS23220	COG3753	Protein conserved in bacteria
I3W_RS23225	COG0187	DNA topoisomerase II activity
I3W_RS23235	COG0592	DNA-directed DNA polymerase activity
I3W_RS23285	COG0814	amino acid
I3W_RS23300	COG2091	lysine biosynthetic process via aminoadipic acid
I3W_RS23305	COG0431	NADPH-dependent FMN reductase
I3W_RS23310	COG2252	PERMEase
I3W_RS23315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3W_RS23325	COG3196	Protein conserved in bacteria
I3W_RS23330	COG0363	glucosamine-6-phosphate deaminase activity
I3W_RS23335	COG2382	esterase
I3W_RS23345	COG2723	6-phospho-beta-galactosidase activity
I3W_RS23350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS23350	COG1263	PTS System
I3W_RS23350	COG2190	(PTS) system
I3W_RS23355	COG3711	transcriptional antiterminator
I3W_RS23360	COG0704	Plays a role in the regulation of phosphate uptake
I3W_RS23365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3W_RS23370	COG0581	inorganic phosphate transmembrane transporter activity
I3W_RS23375	COG0573	inorganic phosphate transmembrane transporter activity
I3W_RS23380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3W_RS23390	COG3188	usher protein
I3W_RS23405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3W_RS23460	COG3312	ion transport
I3W_RS23475	COG0716	FMN binding
I3W_RS23480	COG1522	sequence-specific DNA binding
I3W_RS23510	COG1129	ABC transporter
I3W_RS23515	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS23520	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS23525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS23530	COG1609	Transcriptional regulator
I3W_RS23535	COG0477	Major facilitator Superfamily
I3W_RS23540	COG2186	Transcriptional regulator
I3W_RS23580	COG3085	chromosome segregation
I3W_RS23585	COG0606	chelatase, subunit chli
I3W_RS23610	COG3978	acetolactate synthase activity
I3W_RS23615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3W_RS23625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3W_RS23630	COG0583	DNA-binding transcription factor activity
I3W_RS23640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3W_RS23645	COG3692	DNA binding
I3W_RS23650	COG0210	DNA helicase
I3W_RS23670	COG3118	belongs to the thioredoxin family
I3W_RS23680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I3W_RS23690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3W_RS23695	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I3W_RS23700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3W_RS23705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I3W_RS23710	COG1088	dTDP-glucose 4,6-dehydratase activity
I3W_RS23715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3W_RS23720	COG0456	acetyltransferase
I3W_RS23725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3W_RS23730	COG2244	polysaccharide biosynthetic process
I3W_RS23750	COG1113	amino acid transport
I3W_RS23775	COG0641	radical SAM
I3W_RS23780	COG3071	HemY protein
I3W_RS23785	COG2959	enzyme of heme biosynthesis
I3W_RS23790	COG1587	Uroporphyrinogen-III synthase
I3W_RS23805	COG3072	Adenylate cyclase
I3W_RS23820	COG5567	small periplasmic lipoprotein
I3W_RS23830	COG3159	Protein conserved in bacteria
I3W_RS23840	COG1011	Hydrolase
I3W_RS23845	COG0210	DNA helicase
I3W_RS23850	COG3698	Phosphodiester glycosidase
I3W_RS23855	COG0598	Magnesium transport protein CorA
I3W_RS23885	COG2962	Rard protein
I3W_RS23890	COG2050	protein possibly involved in aromatic compounds catabolism
I3W_RS23895	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I3W_RS23900	COG0514	ATP-dependent DNA helicase (RecQ)
I3W_RS23905	COG1280	lysine exporter protein (LysE YggA)
I3W_RS23910	COG1280	lysine exporter protein (LysE YggA)
I3W_RS23915	COG2267	carboxylic ester hydrolase activity
I3W_RS23920	COG0561	phosphatase activity
I3W_RS23925	COG0697	spore germination
I3W_RS23930	COG0583	DNA-binding transcription factor activity
I3W_RS23940	COG0412	Dienelactone hydrolase
I3W_RS23945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I3W_RS23950	COG1322	Protein conserved in bacteria
I3W_RS23960	COG3165	ubiquinone biosynthetic process from chorismate
I3W_RS23970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3W_RS23975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3W_RS23980	COG0805	protein transport
I3W_RS23990	COG0250	Participates in transcription elongation, termination and antitermination
I3W_RS23995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3W_RS24000	COG0543	2 iron, 2 sulfur cluster binding
I3W_RS24020	COG1739	Uncharacterized protein family UPF0029
I3W_RS24025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3W_RS24030	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I3W_RS24060	COG1763	Mo-molybdopterin cofactor biosynthetic process
I3W_RS24065	COG0746	molybdenum cofactor guanylyltransferase activity
I3W_RS24070	COG3084	Protein conserved in bacteria
I3W_RS24075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3W_RS24080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3W_RS24085	COG5339	Protein conserved in bacteria
I3W_RS24090	COG0204	Acyl-transferase
I3W_RS24100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3W_RS24100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3W_RS24115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3W_RS24125	COG2204	response regulator
I3W_RS24130	COG3852	Histidine kinase
I3W_RS24135	COG0174	glutamine synthetase
I3W_RS24145	COG1217	gtp-binding protein TYPA
I3W_RS24150	COG2188	Transcriptional regulator
I3W_RS24155	COG1082	Xylose isomerase domain protein TIM barrel
I3W_RS24160	COG2271	Major facilitator Superfamily
I3W_RS24165	COG1349	DNA-binding transcription factor activity
I3W_RS24170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3W_RS24175	COG2084	Dehydrogenase
I3W_RS24180	COG3684	Belongs to the aldolase LacD family
I3W_RS24185	COG1063	alcohol dehydrogenase
I3W_RS24195	COG0477	Major facilitator Superfamily
I3W_RS24205	COG1011	Hydrolase
I3W_RS24220	COG0456	acetyltransferase
I3W_RS24230	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I3W_RS24245	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3W_RS24250	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I3W_RS24260	COG2864	formate dehydrogenase
I3W_RS24265	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS24290	COG3711	transcriptional antiterminator
I3W_RS24290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS24295	COG1363	Peptidase, m42
I3W_RS24300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS24300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS24305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS24345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3W_RS24360	COG2258	MOSC domain
I3W_RS24365	COG2205	protein histidine kinase activity
I3W_RS24370	COG0745	RESPONSE REGULATOR receiver
I3W_RS24375	COG3678	ATP-independent chaperone mediated protein folding
I3W_RS24390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I3W_RS24410	COG3152	Membrane
I3W_RS24415	COG3691	Protein conserved in bacteria
I3W_RS24420	COG0589	response to stress
I3W_RS24430	COG1494	fructose-1,6-bisphosphatase
I3W_RS24440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3W_RS24455	COG1575	Belongs to the MenA family. Type 1 subfamily
I3W_RS24470	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3W_RS24475	COG1609	Transcriptional regulator
I3W_RS24480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3W_RS24490	COG3209	COG3209 Rhs family protein
I3W_RS24505	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I3W_RS24515	COG0626	cystathionine gamma-synthase activity
I3W_RS24520	COG0527	aspartate kinase activity
I3W_RS24520	COG0460	homoserine dehydrogenase
I3W_RS24525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3W_RS24535	COG0697	spore germination
I3W_RS24540	COG3738	Protein conserved in bacteria
I3W_RS24545	COG0371	Dehydrogenase
I3W_RS24550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3W_RS24555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3W_RS24555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS24555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3W_RS24560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS24565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS24570	COG1882	Formate acetyltransferase
I3W_RS24575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3W_RS24580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3W_RS24585	COG2207	Transcriptional regulator
I3W_RS24590	COG2194	sulfuric ester hydrolase activity
I3W_RS24605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I3W_RS24620	COG0583	DNA-binding transcription factor activity
I3W_RS24685	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I3W_RS24685	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I3W_RS24730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3W_RS24735	COG0250	Participates in transcription elongation, termination and antitermination
I3W_RS24775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I3W_RS24785	COG2104	thiamine diphosphate biosynthetic process
I3W_RS24790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3W_RS24825	COG3068	Protein conserved in bacteria
I3W_RS24840	COG3678	ATP-independent chaperone mediated protein folding
I3W_RS24850	COG4191	Histidine kinase
I3W_RS24855	COG2204	response regulator
I3W_RS24860	COG0151	Belongs to the GarS family
I3W_RS24895	COG0456	acetyltransferase
I3W_RS24905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I3W_RS24910	COG2224	Isocitrate lyase
I3W_RS24930	COG1414	Transcriptional regulator
I3W_RS24935	COG1410	methionine synthase
I3W_RS24935	COG0646	methionine synthase
I3W_RS24940	COG1283	sodium-dependent phosphate transmembrane transporter activity
I3W_RS24985	COG1187	pseudouridine synthase activity
I3W_RS25000	COG3541	Predicted nucleotidyltransferase
I3W_RS25005	COG0542	response to heat
I3W_RS25010	COG0527	aspartate kinase activity
I3W_RS25045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3W_RS25060	COG2814	Major facilitator Superfamily
I3W_RS25060	COG0477	Major facilitator Superfamily
I3W_RS25065	COG3833	ABC-type maltose transport systems, permease component
I3W_RS25070	COG1175	transmembrane transport
I3W_RS25075	COG2182	Extracellular solute-binding protein
I3W_RS25085	COG3842	ATPase activity
I3W_RS25125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3W_RS25135	COG0534	Mate efflux family protein
I3W_RS25140	COG3237	CsbD-like
I3W_RS25145	COG0735	belongs to the Fur family
I3W_RS25160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3W_RS25170	COG0604	alcohol dehydrogenase
I3W_RS25175	COG0305	Participates in initiation and elongation during chromosome replication
I3W_RS25180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3W_RS25185	COG1448	Aminotransferase
I3W_RS25195	COG3700	Belongs to the class B bacterial acid phosphatase family
I3W_RS25200	COG0432	Pfam Uncharacterised protein family UPF0047
I3W_RS25205	COG2315	Protein conserved in bacteria
I3W_RS25210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3W_RS25220	COG0629	single-stranded DNA binding
I3W_RS25235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I3W_RS25240	COG2207	Transcriptional regulator
I3W_RS25245	COG0789	Transcriptional regulator
I3W_RS25265	COG2252	PERMEase
I3W_RS25270	COG0025	NhaP-type Na H and K H
I3W_RS25275	COG1357	PFAM Pentapeptide repeats (8 copies)
I3W_RS25285	COG3162	membrane
I3W_RS25290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3W_RS25305	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I3W_RS25310	COG0437	4 iron, 4 sulfur cluster binding
I3W_RS25315	COG3301	Polysulphide reductase, NrfD
I3W_RS25320	COG1138	Cytochrome C-type biogenesis protein
I3W_RS25325	COG3088	subunit of a heme lyase
I3W_RS25330	COG4235	cytochrome complex assembly
I3W_RS25340	COG1301	dicarboxylic acid transport
I3W_RS25345	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I3W_RS25360	COG1289	transmembrane transporter activity
I3W_RS25365	COG1566	PFAM secretion protein HlyD family protein
I3W_RS25375	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3W_RS25380	COG1940	carbohydrate kinase activity
I3W_RS25385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3W_RS25390	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS25395	COG1129	ABC transporter
I3W_RS25400	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS25405	COG1737	Transcriptional regulator
I3W_RS25415	COG0698	ribose 5-phosphate isomerase
I3W_RS25425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3W_RS25430	COG0456	acetyltransferase
I3W_RS25435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I3W_RS25440	COG3454	Phosphonate metabolism
I3W_RS25445	COG4778	phosphonate C-P lyase system protein PhnL
I3W_RS25450	COG4107	phosphonate C-P lyase system protein PhnK
I3W_RS25455	COG3627	carbon phosphorus lyase activity
I3W_RS25460	COG3626	phosphonate metabolism
I3W_RS25465	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I3W_RS25470	COG3624	Phosphonate C-P lyase system protein PhnG
I3W_RS25475	COG2188	Transcriptional regulator
I3W_RS25480	COG3639	organic phosphonate transmembrane transporter activity
I3W_RS25485	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I3W_RS25495	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I3W_RS25500	COG2824	Alkylphosphonate utilization operon protein PhnA
I3W_RS25520	COG0477	Major facilitator Superfamily
I3W_RS25530	COG0642	Histidine kinase
I3W_RS25535	COG0745	RESPONSE REGULATOR receiver
I3W_RS25540	COG2194	sulfuric ester hydrolase activity
I3W_RS25545	COG0531	amino acid
I3W_RS25550	COG2207	Transcriptional regulator
I3W_RS25555	COG1982	Orn Lys Arg decarboxylase major
I3W_RS25560	COG2169	Transcriptional regulator
I3W_RS25570	COG1486	melibiose metabolic process
I3W_RS25575	COG2211	Major facilitator Superfamily
I3W_RS25585	COG3647	Membrane
I3W_RS25590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I3W_RS25590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I3W_RS25595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3W_RS25605	COG4565	transcriptional regulatory protein
I3W_RS25610	COG3290	protein histidine kinase activity
I3W_RS25615	COG3592	Divergent 4Fe-4S mono-cluster
I3W_RS25620	COG2388	GCN5-related N-acetyl-transferase
I3W_RS25635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3W_RS25640	COG3104	oligopeptide transport
I3W_RS25645	COG1982	Orn Lys Arg decarboxylase major
I3W_RS25650	COG0531	amino acid
I3W_RS25700	COG2003	Belongs to the UPF0758 family
I3W_RS25740	COG2826	transposase and inactivated derivatives, IS30 family
I3W_RS25750	COG2020	methyltransferase activity
I3W_RS25755	COG3468	outer membrane autotransporter barrel domain protein
I3W_RS25770	COG4983	Phage plasmid primase, P4 family domain protein
I3W_RS25845	COG2831	hemolysin activation secretion protein
I3W_RS25850	COG2994	toxin metabolic process
I3W_RS25855	COG3210	domain, Protein
I3W_RS25900	COG3210	domain, Protein
I3W_RS25930	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I3W_RS25935	COG3969	phosphoadenosine phosphosulfate
I3W_RS25940	COG1475	DNA binding
I3W_RS25985	COG2207	Transcriptional regulator
I3W_RS26015	COG3119	arylsulfatase activity
I3W_RS26040	COG4771	TonB-dependent receptor
I3W_RS26090	COG0183	Belongs to the thiolase family
I3W_RS26095	COG2031	fatty acid transporter
I3W_RS26100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I3W_RS26105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I3W_RS26110	COG2204	response regulator
I3W_RS26115	COG3852	Histidine kinase
I3W_RS26125	COG2194	sulfuric ester hydrolase activity
I3W_RS26150	COG1309	transcriptional regulator
I3W_RS26165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I3W_RS26170	COG1027	Aspartate ammonia-lyase
I3W_RS26175	COG3030	protein affecting phage T7 exclusion by the F plasmid
I3W_RS26180	COG0531	amino acid
I3W_RS26205	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS26215	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS26225	COG1509	lysine 2,3-aminomutase activity
I3W_RS26235	COG5510	response to toxic substance
I3W_RS26240	COG5510	response to toxic substance
I3W_RS26245	COG2076	Multidrug Resistance protein
I3W_RS26250	COG3040	lipid binding
I3W_RS26255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3W_RS26270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3W_RS26275	COG1053	succinate dehydrogenase
I3W_RS26285	COG0531	amino acid
I3W_RS26300	COG1511	domain protein
I3W_RS26300	COG3264	Mechanosensitive ion channel
I3W_RS26340	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I3W_RS26345	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I3W_RS26345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I3W_RS26350	COG0802	atpase or kinase
I3W_RS26355	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3W_RS26375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3W_RS26380	COG0330	HflC and HflK could
I3W_RS26385	COG0330	HflC and HflK could
I3W_RS26390	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I3W_RS26405	COG0557	exoribonuclease II activity
I3W_RS26410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3W_RS26420	COG3789	protein conserved in bacteria
I3W_RS26425	COG1842	Phage shock protein A
I3W_RS26435	COG3766	membrane
I3W_RS26440	COG5463	Belongs to the UPF0441 family
I3W_RS26445	COG0754	glutathionylspermidine amidase activity
I3W_RS26450	COG1960	acyl-CoA dehydrogenase activity
I3W_RS26465	COG3650	response to hydrogen peroxide
I3W_RS26470	COG1073	alpha beta
I3W_RS26485	COG3037	sugar-specific permease SgaT UlaA
I3W_RS26530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3W_RS26540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3W_RS26550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I3W_RS26555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3W_RS26560	COG4670	ketone body catabolic process
I3W_RS26565	COG1024	Enoyl-CoA hydratase
I3W_RS26580	COG1309	transcriptional regulator
I3W_RS26585	COG3061	Opacity-associated protein A
I3W_RS26595	COG0545	Peptidyl-prolyl cis-trans isomerase
I3W_RS26600	COG1113	amino acid transport
I3W_RS26615	COG0702	epimerase
I3W_RS26620	COG1733	regulation of RNA biosynthetic process
I3W_RS26625	COG0737	Belongs to the 5'-nucleotidase family
I3W_RS26630	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3W_RS26635	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I3W_RS26645	COG1253	flavin adenine dinucleotide binding
I3W_RS26660	COG0729	surface antigen
I3W_RS26665	COG2911	Protein conserved in bacteria
I3W_RS26670	COG2105	PFAM AIG2 family protein
I3W_RS26675	COG2336	PFAM SpoVT AbrB
I3W_RS26680	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3W_RS26685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3W_RS26690	COG1879	ABC-type sugar transport system periplasmic component
I3W_RS26695	COG1129	ABC transporter
I3W_RS26700	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS26705	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3W_RS26715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I3W_RS26725	COG0312	modulator of DNA gyrase
I3W_RS26730	COG3783	Cytochrome b(562)
I3W_RS26735	COG0602	queuosine metabolic process
I3W_RS26740	COG1328	CTP reductase activity
I3W_RS26745	COG0366	Alpha amylase catalytic
I3W_RS26750	COG1263	PTS System
I3W_RS26750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3W_RS26755	COG1609	Transcriptional regulator
I3W_RS26765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3W_RS26770	COG3547	Transposase (IS116 IS110 IS902 family)
I3W_RS26780	COG0251	oxidation-reduction process
I3W_RS26805	COG0251	oxidation-reduction process
I3W_RS26810	COG1028	Short-chain dehydrogenase reductase Sdr
I3W_RS26815	COG1309	transcriptional regulator
I3W_RS26820	COG2731	YhcH YjgK YiaL family protein
I3W_RS26835	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I3W_RS26840	COG0456	acetyltransferase
I3W_RS26850	COG0525	valine-tRNA ligase activity
I3W_RS26855	COG2927	DNA polymerase III (CHI subunit)
I3W_RS26865	COG0795	lipopolysaccharide-transporting ATPase activity
I3W_RS26870	COG0795	lipopolysaccharide-transporting ATPase activity
I3W_RS26875	COG0433	COG0433 Predicted ATPase
I3W_RS26880	COG1064	alcohol dehydrogenase
I3W_RS26925	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I3W_RS26940	COG0582	viral genome integration into host DNA
I3W_RS26945	COG4974	Belongs to the 'phage' integrase family
I3W_RS26960	COG3539	Fimbrial protein
I3W_RS26965	COG3121	Chaperone
I3W_RS26970	COG3188	usher protein
I3W_RS26975	COG3539	Fimbrial protein
I3W_RS26980	COG3539	Fimbrial protein
I3W_RS26985	COG3539	Fimbrial protein
I3W_RS26990	COG2610	gluconate transmembrane transporter activity
I3W_RS27005	COG0246	Mannitol dehydrogenase
I3W_RS27015	COG2186	Transcriptional regulator
I3W_RS27035	COG0583	DNA-binding transcription factor activity
I3W_RS27040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3W_RS27045	COG0700	Nucleoside recognition
I3W_RS27050	COG3366	ferrous iron transmembrane transporter activity
I3W_RS27065	COG0477	Major facilitator Superfamily
I3W_RS27080	COG1924	4 iron, 4 sulfur cluster binding
I3W_RS27085	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I3W_RS27090	COG2733	membrane
I3W_RS27095	COG2814	Major facilitator Superfamily
I3W_RS27115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3W_RS27120	COG5457	Domain of unknown function (DUF1127)
I3W_RS27130	COG0523	cobalamin synthesis protein
I3W_RS27135	COG2879	small protein
I3W_RS27140	COG1966	Carbon starvation protein
I3W_RS27150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3W_RS27155	COG2368	4-hydroxyphenylacetate
I3W_RS27175	COG3971	2-oxopent-4-enoate hydratase activity
I3W_RS27185	COG3384	dioxygenase
I3W_RS27190	COG1012	belongs to the aldehyde dehydrogenase family
I3W_RS27195	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3W_RS27200	COG1846	Transcriptional regulator
I3W_RS27205	COG0840	transmembrane signaling receptor activity
I3W_RS27210	COG2271	Major facilitator Superfamily
I3W_RS27215	COG1802	Transcriptional regulator
I3W_RS27220	COG1063	alcohol dehydrogenase
I3W_RS27235	COG1484	DNA-dependent DNA replication
I3W_RS27250	COG2966	Psort location CytoplasmicMembrane, score
I3W_RS27255	COG2197	response regulator
I3W_RS27260	COG2197	response regulator
I3W_RS27265	COG4114	ferric iron reductase
I3W_RS27295	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I3W_RS27300	COG0456	acetyltransferase
I3W_RS27305	COG1011	Hydrolase
I3W_RS27315	COG2823	Periplasmic or secreted lipoprotein
I3W_RS27325	COG4667	esterase of the alpha-beta hydrolase superfamily
I3W_RS27330	COG0084	hydrolase, TatD family'
I3W_RS27335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3W_RS27340	COG1328	CTP reductase activity
I3W_RS27375	COG3726	membrane protein affecting hemolysin expression
I3W_RS27380	COG0560	Phosphoserine phosphatase
I3W_RS27385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3W_RS27390	COG3172	ATPase kinase involved in NAD metabolism
I3W_RS27390	COG1056	cytidyltransferase-related domain
I3W_RS27395	COG0488	(ABC) transporter
I3W_RS27405	COG0741	lytic transglycosylase activity
I3W_RS27425	COG2207	Transcriptional regulator
I3W_RS27425	COG3708	Transcriptional regulator
I3W_RS27430	COG3045	CreA protein
I3W_RS27435	COG0745	RESPONSE REGULATOR receiver
I3W_RS27440	COG2205	protein histidine kinase activity
I3W_RS27445	COG4452	Inner membrane protein CreD
I3W_RS27450	COG0745	RESPONSE REGULATOR receiver
I3W_RS27460	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA