locus-tag	class	description
P12B_RS00010	COG0460	homoserine dehydrogenase
P12B_RS00010	COG0527	aspartate kinase activity
P12B_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
P12B_RS00040	COG1115	amino acid carrier protein
P12B_RS00045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P12B_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
P12B_RS00055	COG1584	GPR1 FUN34 yaaH family protein
P12B_RS00060	COG4735	regulation of single-species biofilm formation
P12B_RS00080	COG3385	transposase activity
P12B_RS00090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
P12B_RS00095	COG0583	DNA-binding transcription factor activity
P12B_RS00135	COG1047	Peptidyl-prolyl cis-trans
P12B_RS00165	COG0505	Belongs to the CarA family
P12B_RS00170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
P12B_RS00225	COG0644	oxidoreductase
P12B_RS00230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
P12B_RS00235	COG2271	Major facilitator Superfamily
P12B_RS00250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
P12B_RS00275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P12B_RS00280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
P12B_RS00285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
P12B_RS00290	COG0564	pseudouridine synthase activity
P12B_RS00300	COG0417	DNA replication proofreading
P12B_RS00305	COG0235	Class ii aldolase
P12B_RS00320	COG4977	sequence-specific DNA binding
P12B_RS00325	COG0586	Pfam SNARE associated Golgi protein
P12B_RS00335	COG1178	ABC-type Fe3 transport system permease component
P12B_RS00340	COG4143	(ABC) transporter
P12B_RS00355	COG2814	Major facilitator Superfamily
P12B_RS00370	COG0473	3-isopropylmalate dehydrogenase activity
P12B_RS00385	COG0583	DNA-binding transcription factor activity
P12B_RS00390	COG0028	Belongs to the TPP enzyme family
P12B_RS00395	COG0440	acetolactate synthase activity
P12B_RS00405	COG1609	Transcriptional regulator
P12B_RS00420	COG3116	cell division
P12B_RS00425	COG0768	penicillin binding
P12B_RS00430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P12B_RS00435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
P12B_RS00445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
P12B_RS00450	COG0772	Belongs to the SEDS family
P12B_RS00465	COG1181	Belongs to the D-alanine--D-alanine ligase family
P12B_RS00470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
P12B_RS00475	COG0849	cell division
P12B_RS00480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
P12B_RS00500	COG0494	nUDIX hydrolase
P12B_RS00520	COG0237	dephospho-CoA kinase activity
P12B_RS00530	COG1459	type II secretion system
P12B_RS00535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P12B_RS00540	COG4969	Belongs to the N-Me-Phe pilin family
P12B_RS00550	COG0157	Belongs to the NadC ModD family
P12B_RS00555	COG3023	N-Acetylmuramoyl-L-alanine amidase
P12B_RS00560	COG3725	Membrane protein required for beta-lactamase induction
P12B_RS00570	COG2186	Transcriptional regulator
P12B_RS00575	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
P12B_RS00580	COG0508	dehydrogenase complex catalyzes the overall conversion of
P12B_RS00585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P12B_RS00590	COG3064	Membrane
P12B_RS00595	COG1049	propionate catabolic process, 2-methylcitrate cycle
P12B_RS00620	COG2132	Multicopper oxidase
P12B_RS00630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
P12B_RS00635	COG0288	reversible hydration of carbon dioxide
P12B_RS00640	COG1131	(ABC) transporter
P12B_RS00645	COG0842	Transport permease protein
P12B_RS00650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS00655	COG0726	polysaccharide deacetylase
P12B_RS00665	COG5464	transposase or invertase
P12B_RS00680	COG3539	Fimbrial protein
P12B_RS00695	COG3121	Chaperone
P12B_RS00700	COG3539	Fimbrial protein
P12B_RS00705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P12B_RS00710	COG0617	tRNA 3'-terminal CCA addition
P12B_RS00720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P12B_RS00730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
P12B_RS00735	COG1643	Atp-dependent helicase
P12B_RS00745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P12B_RS00755	COG1120	ATPase activity
P12B_RS00760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
P12B_RS00785	COG2860	membrane
P12B_RS00790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
P12B_RS00805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P12B_RS00810	COG3835	regulator
P12B_RS00820	COG1408	metallophosphoesterase
P12B_RS00835	COG0024	Methionine aminopeptidase
P12B_RS00860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P12B_RS00865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P12B_RS00870	COG0575	Belongs to the CDS family
P12B_RS00875	COG0750	zinc metalloprotease
P12B_RS00885	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
P12B_RS00890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P12B_RS00915	COG0587	DNA-directed DNA polymerase activity
P12B_RS00925	COG1982	Orn Lys Arg decarboxylase major
P12B_RS00930	COG0346	lactoylglutathione lyase activity
P12B_RS00940	COG4568	rho-dependent transcription termination
P12B_RS00950	COG4681	YaeQ
P12B_RS00955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P12B_RS00960	COG3015	lipoprotein NlpE involved in copper resistance
P12B_RS00965	COG0791	NLP P60 protein
P12B_RS00975	COG1720	tRNA m6t6A37 methyltransferase activity
P12B_RS00985	COG1464	Belongs to the NlpA lipoprotein family
P12B_RS00990	COG2011	ABC-type metal ion transport system permease component
P12B_RS00995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
P12B_RS01000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
P12B_RS01035	COG0656	L-ascorbic acid biosynthetic process
P12B_RS01040	COG0583	DNA-binding transcription factor activity
P12B_RS01050	COG2226	methyltransferase
P12B_RS01055	COG1388	LysM domain
P12B_RS01055	COG0741	lytic transglycosylase activity
P12B_RS01065	COG2226	methyltransferase
P12B_RS01075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P12B_RS01095	COG4104	PAAR repeat-containing protein
P12B_RS01110	COG3209	COG3209 Rhs family protein
P12B_RS01130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P12B_RS01150	COG0121	glutamine amidotransferase
P12B_RS01155	COG3034	peptidoglycan biosynthetic process
P12B_RS01160	COG0791	NLP P60 protein
P12B_RS01165	COG1943	Transposase
P12B_RS01185	COG1987	bacterial-type flagellum assembly
P12B_RS01210	COG1677	Flagellar hook-basal body complex protein FliE
P12B_RS01220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P12B_RS01240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
P12B_RS01270	COG1815	bacterial-type flagellum-dependent cell motility
P12B_RS01275	COG1558	bacterial-type flagellum-dependent cell motility
P12B_RS01285	COG1749	Flagellar hook protein flgE
P12B_RS01290	COG4787	bacterial-type flagellum-dependent cell motility
P12B_RS01295	COG4786	Flagellar basal body rod
P12B_RS01320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
P12B_RS01335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
P12B_RS01340	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
P12B_RS01365	COG1191	sigma factor activity
P12B_RS01370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
P12B_RS01385	COG2161	toxin-antitoxin pair type II binding
P12B_RS01395	COG0454	-acetyltransferase
P12B_RS01400	COG1690	Belongs to the RtcB family
P12B_RS01405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P12B_RS01410	COG2195	Cleaves the N-terminal amino acid of tripeptides
P12B_RS01430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
P12B_RS01460	COG2003	Belongs to the UPF0758 family
P12B_RS01490	COG2378	regulation of single-species biofilm formation
P12B_RS01500	COG3596	GTP binding
P12B_RS01505	COG3039	Transposase
P12B_RS01510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P12B_RS01515	COG0501	Belongs to the peptidase M48B family
P12B_RS01560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P12B_RS01570	COG0542	response to heat
P12B_RS01575	COG0071	Belongs to the small heat shock protein (HSP20) family
P12B_RS01595	COG3328	transposase activity
P12B_RS01610	COG3344	reverse transcriptase
P12B_RS01620	COG2801	Transposase and inactivated derivatives
P12B_RS01625	COG2826	transposase and inactivated derivatives, IS30 family
P12B_RS01660	COG2814	Major facilitator Superfamily
P12B_RS01665	COG0833	amino acid
P12B_RS01670	COG2040	homocysteine
P12B_RS01675	COG3842	ATPase activity
P12B_RS01680	COG1178	ABC-type Fe3 transport system permease component
P12B_RS01685	COG1662	PFAM IS1 transposase
P12B_RS01690	COG3677	Transposase
P12B_RS01690	COG1662	PFAM IS1 transposase
P12B_RS01695	COG3708	Transcriptional regulator
P12B_RS01695	COG2207	Transcriptional regulator
P12B_RS01700	COG3059	membrane
P12B_RS01710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P12B_RS01715	COG2207	Transcriptional regulator
P12B_RS01720	COG0247	lactate metabolic process
P12B_RS01725	COG1139	Iron-sulfur cluster binding protein
P12B_RS01730	COG1556	Lactate utilization protein
P12B_RS01770	COG2771	luxR family
P12B_RS01770	COG2200	EAL domain
P12B_RS01775	COG0583	DNA-binding transcription factor activity
P12B_RS01785	COG0666	response to abiotic stimulus
P12B_RS01795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P12B_RS01800	COG1304	FMN binding
P12B_RS01810	COG0549	Belongs to the carbamate kinase family
P12B_RS01815	COG0402	S-adenosylhomocysteine deaminase activity
P12B_RS01820	COG1064	alcohol dehydrogenase
P12B_RS01835	COG1280	lysine exporter protein (LysE YggA)
P12B_RS01845	COG3829	transcription factor binding
P12B_RS01850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
P12B_RS01855	COG0372	Belongs to the citrate synthase family
P12B_RS01860	COG2079	MmgE PrpD family protein
P12B_RS01865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P12B_RS01870	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
P12B_RS01875	COG0402	S-adenosylhomocysteine deaminase activity
P12B_RS01880	COG0583	DNA-binding transcription factor activity
P12B_RS01885	COG0288	reversible hydration of carbon dioxide
P12B_RS01895	COG2807	transmembrane transport
P12B_RS01900	COG0110	maltose O-acetyltransferase activity
P12B_RS01905	COG2223	nitrite transmembrane transporter activity
P12B_RS01910	COG3250	beta-galactosidase activity
P12B_RS01915	COG1609	Transcriptional regulator
P12B_RS01920	COG1414	Transcriptional regulator
P12B_RS01940	COG3971	2-oxopent-4-enoate hydratase activity
P12B_RS01955	COG2814	Major facilitator Superfamily
P12B_RS01960	COG3122	Protein conserved in bacteria
P12B_RS01990	COG4521	taurine ABC transporter
P12B_RS02000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P12B_RS02005	COG2175	clavaminate synthase activity
P12B_RS02010	COG0113	porphobilinogen synthase activity
P12B_RS02015	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS02030	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS02035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P12B_RS02040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
P12B_RS02050	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
P12B_RS02070	COG1181	Belongs to the D-alanine--D-alanine ligase family
P12B_RS02085	COG1785	Belongs to the alkaline phosphatase family
P12B_RS02095	COG3706	GGDEF domain
P12B_RS02100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
P12B_RS02125	COG4126	flavin adenine dinucleotide binding
P12B_RS02145	COG1940	carbohydrate kinase activity
P12B_RS02155	COG0419	ATPase involved in DNA repair
P12B_RS02160	COG0420	3'-5' exonuclease activity
P12B_RS02165	COG0745	RESPONSE REGULATOR receiver
P12B_RS02170	COG5002	protein histidine kinase activity
P12B_RS02175	COG1114	Component of the transport system for branched-chain amino acids
P12B_RS02180	COG1113	amino acid transport
P12B_RS02185	COG0366	Alpha amylase catalytic
P12B_RS02205	COG1862	Preprotein translocase
P12B_RS02210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P12B_RS02215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P12B_RS02220	COG1403	HNH endonuclease
P12B_RS02230	COG3248	Nucleoside-binding outer membrane protein
P12B_RS02235	COG4238	major outer membrane lipoprotein
P12B_RS02245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P12B_RS02245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P12B_RS02260	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P12B_RS02265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
P12B_RS02270	COG0667	Aldo Keto reductase
P12B_RS02280	COG0142	geranyltranstransferase activity
P12B_RS02295	COG0693	protein deglycase activity
P12B_RS02300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
P12B_RS02310	COG2814	Major facilitator Superfamily
P12B_RS02320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
P12B_RS02325	COG1845	cytochrome c oxidase, subunit III
P12B_RS02330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P12B_RS02335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
P12B_RS02340	COG2223	nitrite transmembrane transporter activity
P12B_RS02345	COG3056	Lipoprotein
P12B_RS02350	COG0271	Belongs to the BolA IbaG family
P12B_RS02375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P12B_RS02380	COG0776	regulation of translation
P12B_RS02385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P12B_RS02390	COG1555	photosystem II stabilization
P12B_RS02395	COG0824	Thioesterase
P12B_RS02405	COG4533	DNA binding
P12B_RS02415	COG1522	sequence-specific DNA binding
P12B_RS02420	COG1132	(ABC) transporter
P12B_RS02425	COG1132	(ABC) transporter
P12B_RS02430	COG0347	Belongs to the P(II) protein family
P12B_RS02435	COG0004	ammonium transporteR
P12B_RS02440	COG1946	Acyl-CoA thioesterase
P12B_RS02445	COG3126	Type III secretion system lipoprotein chaperone (YscW)
P12B_RS02450	COG3695	enzyme binding
P12B_RS02455	COG5507	3-demethylubiquinone-9 3-methyltransferase
P12B_RS02460	COG4943	cyclic-guanylate-specific phosphodiesterase activity
P12B_RS02470	COG0110	maltose O-acetyltransferase activity
P12B_RS02485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P12B_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS02495	COG1309	transcriptional regulator
P12B_RS02500	COG3264	Mechanosensitive ion channel
P12B_RS02500	COG1196	nuclear chromosome segregation
P12B_RS02515	COG3923	Primosomal replication protein n
P12B_RS02520	COG2832	Protein of unknown function (DUF454)
P12B_RS02570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
P12B_RS02570	COG4651	solute:proton antiporter activity
P12B_RS02575	COG2223	nitrite transmembrane transporter activity
P12B_RS02580	COG0737	Belongs to the 5'-nucleotidase family
P12B_RS02585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
P12B_RS02590	COG3735	TraB family
P12B_RS02595	COG3093	addiction module antidote protein HigA
P12B_RS02600	COG2217	Heavy metal translocating P-type atpase
P12B_RS02605	COG2066	Belongs to the glutaminase family
P12B_RS02610	COG0531	amino acid
P12B_RS02615	COG0789	Transcriptional regulator
P12B_RS02620	COG1585	Membrane protein implicated in regulation of membrane protease activity
P12B_RS02625	COG0330	HflC and HflK could
P12B_RS02630	COG4619	ABC transporter
P12B_RS02635	COG0390	transport system, permease component
P12B_RS02640	COG3118	belongs to the thioredoxin family
P12B_RS02645	COG0300	oxidoreductase activity
P12B_RS02650	COG2755	lipolytic protein G-D-S-L family
P12B_RS02655	COG4181	ATPase activity
P12B_RS02660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
P12B_RS02665	COG3209	COG3209 Rhs family protein
P12B_RS02675	COG3209	COG3209 Rhs family protein
P12B_RS02685	COG2801	Transposase and inactivated derivatives
P12B_RS02695	COG0583	DNA-binding transcription factor activity
P12B_RS02705	COG1414	Transcriptional regulator
P12B_RS02710	COG3960	tartronate-semialdehyde synthase activity
P12B_RS02715	COG3622	Belongs to the hyi family
P12B_RS02720	COG2084	Dehydrogenase
P12B_RS02735	COG1953	Uracil, thiamine, allantoin
P12B_RS02745	COG2233	PERMEase
P12B_RS02750	COG1929	Belongs to the glycerate kinase type-1 family
P12B_RS02755	COG3257	ureidoglycine aminohydrolase activity
P12B_RS02760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
P12B_RS02765	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
P12B_RS02775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P12B_RS02785	COG0549	Belongs to the carbamate kinase family
P12B_RS02790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P12B_RS02795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
P12B_RS02805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P12B_RS02815	COG1988	membrane-bound metal-dependent
P12B_RS02820	COG2501	S4 domain
P12B_RS02835	COG3188	usher protein
P12B_RS02840	COG3539	Fimbrial protein
P12B_RS02845	COG3539	Fimbrial protein
P12B_RS02850	COG2197	response regulator
P12B_RS02870	COG4783	chaperone-mediated protein folding
P12B_RS02880	COG5002	protein histidine kinase activity
P12B_RS02885	COG0745	RESPONSE REGULATOR receiver
P12B_RS02890	COG1538	Outer membrane efflux protein
P12B_RS02895	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS02900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS02905	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P12B_RS02910	COG1113	amino acid transport
P12B_RS02915	COG0668	transmembrane transport
P12B_RS02920	COG0778	Nitroreductase
P12B_RS02925	COG2315	Protein conserved in bacteria
P12B_RS02950	COG3385	transposase activity
P12B_RS02955	COG2977	Belongs to the P-Pant transferase superfamily
P12B_RS02960	COG4771	TonB-dependent receptor
P12B_RS02965	COG2382	esterase
P12B_RS02970	COG3251	PFAM MbtH domain protein
P12B_RS02975	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
P12B_RS02975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
P12B_RS02985	COG1120	ATPase activity
P12B_RS02990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
P12B_RS02995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
P12B_RS03005	COG4592	Periplasmic binding protein
P12B_RS03010	COG1169	isochorismate synthase
P12B_RS03015	COG1021	2,3-dihydroxybenzoate-AMP ligase
P12B_RS03020	COG1535	isochorismatase
P12B_RS03020	COG3433	isochorismatase activity
P12B_RS03025	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS03030	COG2050	protein possibly involved in aromatic compounds catabolism
P12B_RS03035	COG1966	Carbon starvation protein
P12B_RS03040	COG2879	small protein
P12B_RS03045	COG0371	Dehydrogenase
P12B_RS03050	COG0436	Aminotransferase
P12B_RS03055	COG1475	DNA binding
P12B_RS03060	COG3969	phosphoadenosine phosphosulfate
P12B_RS03065	COG0583	DNA-binding transcription factor activity
P12B_RS03070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P12B_RS03075	COG0450	alkyl hydroperoxide reductase
P12B_RS03080	COG3634	alkyl hydroperoxide reductase activity
P12B_RS03085	COG0589	response to stress
P12B_RS03090	COG1063	alcohol dehydrogenase
P12B_RS03100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P12B_RS03105	COG3719	Belongs to the RNase T2 family
P12B_RS03110	COG0471	metal ion transport
P12B_RS03125	COG3051	citrate lyase alpha subunit
P12B_RS03130	COG2301	Belongs to the HpcH HpaI aldolase family
P12B_RS03140	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
P12B_RS03145	COG3290	protein histidine kinase activity
P12B_RS03150	COG4565	transcriptional regulatory protein
P12B_RS03155	COG3069	C4-dicarboxylate transmembrane transporter activity
P12B_RS03180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P12B_RS03190	COG0583	DNA-binding transcription factor activity
P12B_RS03210	COG1686	Belongs to the peptidase S11 family
P12B_RS03215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
P12B_RS03220	COG0772	Belongs to the SEDS family
P12B_RS03225	COG0768	penicillin binding
P12B_RS03235	COG0799	negative regulation of ribosome biogenesis
P12B_RS03250	COG1466	dna polymerase III delta subunit
P12B_RS03265	COG2888	peptidyl-tyrosine sulfation
P12B_RS03270	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
P12B_RS03280	COG2214	Heat shock protein DnaJ domain protein
P12B_RS03285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
P12B_RS03300	COG2214	Heat shock protein DnaJ domain protein
P12B_RS03305	COG0443	Heat shock 70 kDa protein
P12B_RS03315	COG1126	abc transporter atp-binding protein
P12B_RS03320	COG0765	amino acid transport
P12B_RS03325	COG0765	amino acid transport
P12B_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS03335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
P12B_RS03340	COG4535	Mg2 and Co2 transporter CorC
P12B_RS03350	COG1702	phosphate starvation-inducible protein PhoH
P12B_RS03360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P12B_RS03400	COG0367	asparagine synthase
P12B_RS03405	COG0647	UMP catabolic process
P12B_RS03410	COG1846	Transcriptional regulator
P12B_RS03410	COG1940	carbohydrate kinase activity
P12B_RS03415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
P12B_RS03425	COG2190	(PTS) system
P12B_RS03425	COG1263	PTS System
P12B_RS03425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS03445	COG0735	belongs to the Fur family
P12B_RS03460	COG0716	FMN binding
P12B_RS03470	COG0596	Alpha beta hydrolase
P12B_RS03475	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
P12B_RS03480	COG0033	Phosphoglucomutase
P12B_RS03510	COG0745	RESPONSE REGULATOR receiver
P12B_RS03515	COG2205	protein histidine kinase activity
P12B_RS03545	COG3209	COG3209 Rhs family protein
P12B_RS03555	COG3209	COG3209 Rhs family protein
P12B_RS03565	COG5433	transposase activity
P12B_RS03575	COG5433	transposase activity
P12B_RS03580	COG3272	Protein of unknown function (DUF1722)
P12B_RS03585	COG0415	Belongs to the DNA photolyase family
P12B_RS03590	COG3104	oligopeptide transport
P12B_RS03595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
P12B_RS03600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
P12B_RS03605	COG1984	allophanate hydrolase subunit 2
P12B_RS03620	COG3180	Ammonia monooxygenase
P12B_RS03625	COG3539	Fimbrial protein
P12B_RS03630	COG3121	Chaperone
P12B_RS03635	COG3188	usher protein
P12B_RS03640	COG3539	Fimbrial protein
P12B_RS03645	COG0372	Belongs to the citrate synthase family
P12B_RS03655	COG2009	succinate dehydrogenase
P12B_RS03660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
P12B_RS03665	COG1053	succinate dehydrogenase
P12B_RS03670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
P12B_RS03680	COG0567	Dehydrogenase, E1 component
P12B_RS03685	COG0508	dehydrogenase complex catalyzes the overall conversion of
P12B_RS03695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P12B_RS03700	COG2188	Transcriptional regulator
P12B_RS03705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS03705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS03705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS03710	COG0383	alpha-mannosidase activity
P12B_RS03725	COG1294	oxidase, subunit
P12B_RS03730	COG4890	Cyd operon protein YbgT
P12B_RS03735	COG3790	cyd operon protein YbgE
P12B_RS03740	COG0824	Thioesterase
P12B_RS03745	COG0811	peptide transport
P12B_RS03750	COG0848	biopolymer transport protein
P12B_RS03755	COG3064	Membrane
P12B_RS03765	COG2885	chlorophyll binding
P12B_RS03770	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
P12B_RS03815	COG3201	nicotinamide mononucleotide transporter
P12B_RS03820	COG1230	cation diffusion facilitator family transporter
P12B_RS03835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P12B_RS03845	COG2017	converts alpha-aldose to the beta-anomer
P12B_RS03855	COG1085	galactose-1-phosphate uridylyltransferase
P12B_RS03865	COG1119	ATPase activity
P12B_RS03875	COG3585	molybdate ion transport
P12B_RS03875	COG2005	Transcriptional regulator
P12B_RS03885	COG0725	ABC transporter, periplasmic molybdate-binding protein
P12B_RS03890	COG4149	molybdate abc transporter
P12B_RS03895	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
P12B_RS03900	COG0561	phosphatase activity
P12B_RS03910	COG0583	DNA-binding transcription factor activity
P12B_RS03920	COG0471	metal ion transport
P12B_RS03925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
P12B_RS03930	COG4677	pectinesterase activity
P12B_RS03935	COG0582	viral genome integration into host DNA
P12B_RS03950	COG1662	PFAM IS1 transposase
P12B_RS04050	COG3772	lysozyme
P12B_RS04070	COG5562	phage envelope protein
P12B_RS04100	COG5301	cellulose 1,4-beta-cellobiosidase activity
P12B_RS04115	COG2207	Transcriptional regulator
P12B_RS04125	COG2963	transposase activity
P12B_RS04130	COG1881	PFAM PEBP family protein
P12B_RS04135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P12B_RS04155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P12B_RS04165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
P12B_RS04180	COG0521	Mo-molybdopterin cofactor biosynthetic process
P12B_RS04190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
P12B_RS04195	COG0314	molybdopterin synthase activity
P12B_RS04200	COG0670	Belongs to the BI1 family
P12B_RS04205	COG0670	Belongs to the BI1 family
P12B_RS04210	COG0392	lysyltransferase activity
P12B_RS04215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P12B_RS04220	COG3568	Endonuclease Exonuclease Phosphatase
P12B_RS04230	COG0842	Transport permease protein
P12B_RS04235	COG0842	Transport permease protein
P12B_RS04250	COG1309	transcriptional regulator
P12B_RS04255	COG0513	Belongs to the DEAD box helicase family
P12B_RS04260	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
P12B_RS04265	COG1199	ATP-dependent helicase activity
P12B_RS04270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P12B_RS04275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
P12B_RS04285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P12B_RS04310	COG0668	transmembrane transport
P12B_RS04315	COG1126	abc transporter atp-binding protein
P12B_RS04320	COG0765	amino acid transport
P12B_RS04325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS04340	COG5006	permease, DMT superfamily
P12B_RS04345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
P12B_RS04350	COG2194	sulfuric ester hydrolase activity
P12B_RS04360	COG1321	iron dependent repressor
P12B_RS04365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
P12B_RS04370	COG1376	ErfK ybiS ycfS ynhG family protein
P12B_RS04375	COG0488	(ABC) transporter
P12B_RS04385	COG0561	phosphatase activity
P12B_RS04390	COG1882	Formate acetyltransferase
P12B_RS04395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
P12B_RS04400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P12B_RS04405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P12B_RS04410	COG0303	'Molybdopterin
P12B_RS04415	COG1446	asparaginase
P12B_RS04420	COG4172	Belongs to the ABC transporter superfamily
P12B_RS04425	COG0747	negative chemotaxis
P12B_RS04435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P12B_RS04440	COG2200	EAL domain
P12B_RS04445	COG2199	diguanylate cyclase activity
P12B_RS04460	COG2133	pyrroloquinoline quinone binding
P12B_RS04465	COG0625	glutathione transferase activity
P12B_RS04470	COG1686	Belongs to the peptidase S11 family
P12B_RS04475	COG1349	DNA-binding transcription factor activity
P12B_RS04480	COG0671	phosphoesterase, PA-phosphatase related
P12B_RS04485	COG2814	Major facilitator Superfamily
P12B_RS04495	COG0561	phosphatase activity
P12B_RS04500	COG0738	Major facilitator superfamily
P12B_RS04505	COG3226	Transcriptional regulator
P12B_RS04520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P12B_RS04530	COG0778	Nitroreductase
P12B_RS04555	COG3842	ATPase activity
P12B_RS04560	COG1176	ABC-type spermidine putrescine transport system, permease component I
P12B_RS04565	COG1177	transmembrane transport
P12B_RS04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS04585	COG4160	amino acid transport
P12B_RS04590	COG4215	(ABC) transporter
P12B_RS04595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS04600	COG1126	abc transporter atp-binding protein
P12B_RS04615	COG3023	N-Acetylmuramoyl-L-alanine amidase
P12B_RS04620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P12B_RS04625	COG0702	epimerase
P12B_RS04630	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
P12B_RS04635	COG0028	Belongs to the TPP enzyme family
P12B_RS04640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P12B_RS04650	COG2431	L-lysine efflux transmembrane transporter activity
P12B_RS04665	COG3593	DNA synthesis involved in DNA repair
P12B_RS04670	COG2990	Protein conserved in bacteria
P12B_RS04675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS04680	COG0577	efflux transmembrane transporter activity
P12B_RS04680	COG1136	(ABC) transporter
P12B_RS04685	COG1278	Cold shock
P12B_RS04715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
P12B_RS04720	COG4988	ABC transporter
P12B_RS04725	COG0492	ferredoxin-NADP+ reductase activity
P12B_RS04730	COG1522	sequence-specific DNA binding
P12B_RS04735	COG1178	ABC-type Fe3 transport system permease component
P12B_RS04735	COG1674	ftsk spoiiie
P12B_RS04745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P12B_RS04755	COG0243	molybdopterin cofactor binding
P12B_RS04760	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS04765	COG3302	dmso reductase anchor subunit
P12B_RS04770	COG1335	isochorismatase
P12B_RS04780	COG0531	amino acid
P12B_RS04785	COG0583	DNA-binding transcription factor activity
P12B_RS04790	COG0583	DNA-binding transcription factor activity
P12B_RS04795	COG2249	NAD(P)H dehydrogenase (quinone) activity
P12B_RS04800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
P12B_RS04805	COG1882	Formate acetyltransferase
P12B_RS04810	COG2116	formate transmembrane transporter activity
P12B_RS04815	COG1944	ATP diphosphatase activity
P12B_RS04820	COG2323	membrane
P12B_RS04835	COG0501	Belongs to the peptidase M48B family
P12B_RS04845	COG0539	negative regulation of cytoplasmic translation
P12B_RS04855	COG0658	competence protein
P12B_RS04855	COG2333	competence protein COMEC
P12B_RS04865	COG1663	tetraacyldisaccharide 4'-kinase activity
P12B_RS04885	COG3173	Aminoglycoside phosphotransferase
P12B_RS04890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
P12B_RS04895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P12B_RS04905	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
P12B_RS04920	COG3108	Peptidase M15
P12B_RS04925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P12B_RS04930	COG1448	Aminotransferase
P12B_RS04955	COG0308	aminopeptidase N
P12B_RS04960	COG1116	anion transmembrane transporter activity
P12B_RS04965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
P12B_RS04975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
P12B_RS04980	COG0431	NADPH-dependent FMN reductase
P12B_RS04985	COG3539	Fimbrial protein
P12B_RS04990	COG3121	Chaperone
P12B_RS04995	COG3188	usher protein
P12B_RS05000	COG3539	Fimbrial protein
P12B_RS05005	COG3539	Fimbrial protein
P12B_RS05010	COG3539	Fimbrial protein
P12B_RS05015	COG3121	Chaperone
P12B_RS05030	COG0633	Ferredoxin
P12B_RS05030	COG3217	Mosc domain protein beta barrel domain protein
P12B_RS05040	COG0488	(ABC) transporter
P12B_RS05045	COG2995	paraquat-inducible protein a
P12B_RS05050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
P12B_RS05050	COG3008	intermembrane lipid transfer
P12B_RS05055	COG3009	Protein conserved in bacteria
P12B_RS05060	COG3130	regulation of translation
P12B_RS05070	COG1067	ATP-dependent peptidase activity
P12B_RS05080	COG2885	chlorophyll binding
P12B_RS05080	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
P12B_RS05095	COG3070	regulator of competence-specific genes
P12B_RS05100	COG1289	transmembrane transporter activity
P12B_RS05110	COG0210	DNA helicase
P12B_RS05130	COG1832	CoA-binding protein
P12B_RS05145	COG1254	Belongs to the acylphosphatase family
P12B_RS05150	COG2920	part of a sulfur-relay system
P12B_RS05155	COG0670	Belongs to the BI1 family
P12B_RS05165	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
P12B_RS05170	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
P12B_RS05175	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
P12B_RS05180	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
P12B_RS05185	COG1999	signal sequence binding
P12B_RS05190	COG1773	rubredoxin
P12B_RS05195	COG1271	oxidase subunit
P12B_RS05200	COG1294	oxidase, subunit
P12B_RS05215	COG0489	protein tyrosine kinase activity
P12B_RS05215	COG3206	protein involved in exopolysaccharide biosynthesis
P12B_RS05220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P12B_RS05225	COG1596	polysaccharide export
P12B_RS05230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P12B_RS05255	COG1278	Cold shock
P12B_RS05260	COG1278	Cold shock
P12B_RS05275	COG0348	domain, Protein
P12B_RS05280	COG0784	Response regulator, receiver
P12B_RS05280	COG2198	Histidine kinase
P12B_RS05280	COG2205	protein histidine kinase activity
P12B_RS05285	COG1879	ABC-type sugar transport system periplasmic component
P12B_RS05290	COG0745	RESPONSE REGULATOR receiver
P12B_RS05295	COG3005	denitrification pathway
P12B_RS05300	COG0243	molybdopterin cofactor binding
P12B_RS05305	COG3381	protein complex oligomerization
P12B_RS05345	COG3729	General stress protein
P12B_RS05350	COG2233	PERMEase
P12B_RS05385	COG1309	transcriptional regulator
P12B_RS05390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
P12B_RS05390	COG0506	proline dehydrogenase activity
P12B_RS05390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
P12B_RS05400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
P12B_RS05415	COG2822	iron ion transport
P12B_RS05420	COG2837	iron assimilation
P12B_RS05430	COG1702	phosphate starvation-inducible protein PhoH
P12B_RS05435	COG3658	cytochrome
P12B_RS05440	COG1215	transferase activity, transferring glycosyl groups
P12B_RS05445	COG1649	PFAM Uncharacterised BCR, COG1649
P12B_RS05445	COG0726	polysaccharide deacetylase
P12B_RS05450	COG0457	Tetratricopeptide repeat
P12B_RS05455	COG3706	GGDEF domain
P12B_RS05470	COG2963	transposase activity
P12B_RS05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS05480	COG1349	DNA-binding transcription factor activity
P12B_RS05500	COG3436	PFAM IS66 Orf2 family protein
P12B_RS05505	COG2433	Pfam Transposase IS66
P12B_RS05515	COG4771	TonB-dependent receptor
P12B_RS05540	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
P12B_RS05555	COG1376	ErfK ybiS ycfS ynhG family protein
P12B_RS05565	COG0583	DNA-binding transcription factor activity
P12B_RS05570	COG0583	DNA-binding transcription factor activity
P12B_RS05580	COG0534	Mate efflux family protein
P12B_RS05590	COG0217	transcriptional regulatory protein
P12B_RS05595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
P12B_RS05600	COG0477	Major facilitator Superfamily
P12B_RS05610	COG1388	LysM domain
P12B_RS05610	COG1470	cell adhesion involved in biofilm formation
P12B_RS05625	COG3344	reverse transcriptase
P12B_RS05635	COG2373	Large extracellular alpha-helical protein
P12B_RS05635	COG1388	LysM domain
P12B_RS05635	COG4932	domain protein
P12B_RS05640	COG1388	LysM domain
P12B_RS05640	COG1470	cell adhesion involved in biofilm formation
P12B_RS05650	COG3436	PFAM IS66 Orf2 family protein
P12B_RS05655	COG2433	Pfam Transposase IS66
P12B_RS05695	COG3038	cytochrome b561
P12B_RS05705	COG3443	Belongs to the bacterial solute-binding protein 9 family
P12B_RS05720	COG2351	hydroxyisourate hydrolase activity
P12B_RS05725	COG0745	RESPONSE REGULATOR receiver
P12B_RS05730	COG2205	protein histidine kinase activity
P12B_RS05745	COG3039	Transposase
P12B_RS05755	COG2826	transposase and inactivated derivatives, IS30 family
P12B_RS05765	COG2963	transposase activity
P12B_RS05770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
P12B_RS05785	COG1418	mRNA catabolic process
P12B_RS05790	COG0270	DNA (cytosine-5-)-methyltransferase activity
P12B_RS05795	COG3727	T/G mismatch-specific endonuclease activity
P12B_RS05800	COG0697	spore germination
P12B_RS05805	COG2354	Protein conserved in bacteria
P12B_RS05810	COG5475	Uncharacterized small protein (DUF2158)
P12B_RS05835	COG2197	response regulator
P12B_RS05840	COG1684	flagellar biosynthetic protein fliR
P12B_RS05845	COG1987	bacterial-type flagellum assembly
P12B_RS05850	COG1338	Plays a role in the flagellum-specific transport system
P12B_RS05855	COG3190	flagellar
P12B_RS05860	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P12B_RS05865	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P12B_RS05870	COG1580	Controls the rotational direction of flagella during chemotaxis
P12B_RS05875	COG3144	bacterial-type flagellum assembly
P12B_RS05880	COG2882	bacterial-type flagellum organization
P12B_RS05885	COG1157	protein secretion by the type III secretion system
P12B_RS05890	COG1317	bacterial-type flagellum organization
P12B_RS05895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
P12B_RS05900	COG1766	The M ring may be actively involved in energy transduction
P12B_RS05910	COG0582	viral genome integration into host DNA
P12B_RS05980	COG3723	Recombinational DNA repair protein, rece pathway
P12B_RS06225	COG2076	Multidrug Resistance protein
P12B_RS06230	COG1881	PFAM PEBP family protein
P12B_RS06235	COG2207	Transcriptional regulator
P12B_RS06245	COG2135	peptidase activity
P12B_RS06250	COG0425	Belongs to the sulfur carrier protein TusA family
P12B_RS06255	COG2391	methyltransferase activity
P12B_RS06265	COG0366	Alpha amylase catalytic
P12B_RS06275	COG1516	flagellar protein fliS
P12B_RS06280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
P12B_RS06295	COG1662	PFAM IS1 transposase
P12B_RS06305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS06315	COG0765	amino acid transport
P12B_RS06320	COG1126	abc transporter atp-binding protein
P12B_RS06325	COG2197	response regulator
P12B_RS06340	COG2197	response regulator
P12B_RS06370	COG1760	l-serine dehydratase
P12B_RS06375	COG0814	amino acid
P12B_RS06385	COG3039	Transposase
P12B_RS06405	COG3677	Transposase
P12B_RS06405	COG1662	PFAM IS1 transposase
P12B_RS06410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
P12B_RS06415	COG0675	Transposase, IS605 OrfB family
P12B_RS06435	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
P12B_RS06450	COG3344	reverse transcriptase
P12B_RS06455	COG2801	Transposase and inactivated derivatives
P12B_RS06480	COG3344	reverse transcriptase
P12B_RS06485	COG2801	Transposase and inactivated derivatives
P12B_RS06495	COG3318	Belongs to the UPF0149 family
P12B_RS06495	COG3012	SEC-C Motif Domain Protein
P12B_RS06500	COG0814	amino acid
P12B_RS06510	COG1528	Iron-storage protein
P12B_RS06535	COG1528	Iron-storage protein
P12B_RS06540	COG1879	ABC-type sugar transport system periplasmic component
P12B_RS06550	COG1172	Belongs to the binding-protein-dependent transport system permease family
P12B_RS06555	COG1877	trehalose-phosphatase activity
P12B_RS06565	COG0589	response to stress
P12B_RS06580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
P12B_RS06585	COG1360	Flagellar Motor Protein
P12B_RS06590	COG2198	Histidine kinase
P12B_RS06590	COG0643	Histidine kinase
P12B_RS06595	COG0835	chemotaxis
P12B_RS06600	COG0840	transmembrane signaling receptor activity
P12B_RS06605	COG0840	transmembrane signaling receptor activity
P12B_RS06610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
P12B_RS06615	COG2201	protein-glutamate methylesterase activity
P12B_RS06620	COG0745	RESPONSE REGULATOR receiver
P12B_RS06625	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
P12B_RS06630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
P12B_RS06635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
P12B_RS06645	COG3755	Protein conserved in bacteria
P12B_RS06655	COG3102	Protein conserved in bacteria
P12B_RS06665	COG3039	Transposase
P12B_RS06670	COG3005	denitrification pathway
P12B_RS06675	COG0243	molybdopterin cofactor binding
P12B_RS06690	COG3788	relative of glutathione S-transferase, MAPEG superfamily
P12B_RS06695	COG1801	Protein of unknown function DUF72
P12B_RS06700	COG1335	isochorismatase
P12B_RS06710	COG0494	nUDIX hydrolase
P12B_RS06715	COG0217	transcriptional regulatory protein
P12B_RS06740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P12B_RS06750	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
P12B_RS06755	COG0739	heme binding
P12B_RS06765	COG0469	pyruvate kinase activity
P12B_RS06770	COG1737	Transcriptional regulator
P12B_RS06780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
P12B_RS06785	COG0129	dihydroxy-acid dehydratase activity
P12B_RS06790	COG0800	Aldolase
P12B_RS06800	COG3141	response to X-ray
P12B_RS06815	COG2979	Protein of unknown function (DUF533)
P12B_RS06820	COG1770	oligopeptidase
P12B_RS06825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P12B_RS06830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P12B_RS06840	COG2372	response to copper ion
P12B_RS06845	COG1276	copper resistance
P12B_RS06860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
P12B_RS06880	COG3008	intermembrane lipid transfer
P12B_RS06885	COG2995	paraquat-inducible protein a
P12B_RS06890	COG1956	GAF domain-containing protein
P12B_RS06900	COG0793	Belongs to the peptidase S41A family
P12B_RS06910	COG2814	Major facilitator Superfamily
P12B_RS06915	COG1414	Transcriptional regulator
P12B_RS06950	COG2226	methyltransferase
P12B_RS06975	COG3716	PTS system mannose fructose sorbose family IID component
P12B_RS06980	COG3715	PTS system
P12B_RS06985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS06985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS06995	COG1253	flavin adenine dinucleotide binding
P12B_RS07000	COG2200	EAL domain
P12B_RS07005	COG1760	l-serine dehydratase
P12B_RS07015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P12B_RS07030	COG0251	oxidation-reduction process
P12B_RS07035	COG1199	ATP-dependent helicase activity
P12B_RS07040	COG1214	PFAM Peptidase M22, glycoprotease
P12B_RS07045	COG3065	identical protein binding
P12B_RS07050	COG0318	PFAM AMP-dependent synthetase and ligase
P12B_RS07055	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
P12B_RS07060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P12B_RS07065	COG4638	Rieske (2fe-2S)
P12B_RS07070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
P12B_RS07075	COG0473	3-isopropylmalate dehydrogenase activity
P12B_RS07080	COG0583	DNA-binding transcription factor activity
P12B_RS07090	COG3615	Tellurite resistance protein tehB
P12B_RS07100	COG2261	transglycosylase associated protein
P12B_RS07110	COG2199	diguanylate cyclase activity
P12B_RS07110	COG2203	Gaf domain
P12B_RS07115	COG3042	response to heat
P12B_RS07120	COG3189	MarR family transcriptional regulator
P12B_RS07125	COG2807	transmembrane transport
P12B_RS07130	COG2207	Transcriptional regulator
P12B_RS07145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
P12B_RS07155	COG2199	diguanylate cyclase activity
P12B_RS07165	COG2199	diguanylate cyclase activity
P12B_RS07175	COG2766	serine protein kinase
P12B_RS07180	COG3713	MltA-interacting MipA family protein
P12B_RS07190	COG0676	glucose-6-phosphate 1-epimerase activity
P12B_RS07195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P12B_RS07205	COG3139	Protein of unknown function (DUF1315)
P12B_RS07210	COG1063	alcohol dehydrogenase
P12B_RS07215	COG2271	Major facilitator Superfamily
P12B_RS07220	COG1063	alcohol dehydrogenase
P12B_RS07230	COG0191	fructose-bisphosphate aldolase activity
P12B_RS07235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS07240	COG0667	Aldo Keto reductase
P12B_RS07245	COG1349	DNA-binding transcription factor activity
P12B_RS07250	COG2814	Major facilitator Superfamily
P12B_RS07255	COG1335	isochorismatase
P12B_RS07265	COG0616	signal peptide processing
P12B_RS07285	COG0709	Synthesizes selenophosphate from selenide and ATP
P12B_RS07290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P12B_RS07305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
P12B_RS07315	COG0494	nUDIX hydrolase
P12B_RS07320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P12B_RS07325	COG2897	thiosulfate sulfurtransferase activity
P12B_RS07330	COG4136	ATPase activity
P12B_RS07335	COG4135	transport system, permease component
P12B_RS07340	COG4134	Bacterial extracellular solute-binding protein
P12B_RS07345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
P12B_RS07350	COG0398	Pfam SNARE associated Golgi protein
P12B_RS07360	COG0398	Pfam SNARE associated Golgi protein
P12B_RS07365	COG0708	Exodeoxyribonuclease III
P12B_RS07395	COG3678	ATP-independent chaperone mediated protein folding
P12B_RS07405	COG0322	excinuclease ABC activity
P12B_RS07420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P12B_RS07425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
P12B_RS07430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
P12B_RS07435	COG1447	Phosphotransferase system cellobiose-specific component IIA
P12B_RS07440	COG1917	Cupin 2, conserved barrel domain protein
P12B_RS07440	COG2169	Transcriptional regulator
P12B_RS07445	COG1486	melibiose metabolic process
P12B_RS07455	COG0753	catalase activity
P12B_RS07470	COG1823	symporter activity
P12B_RS07475	COG1988	membrane-bound metal-dependent
P12B_RS07480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
P12B_RS07490	COG3001	Fructosamine kinase
P12B_RS07505	COG3137	Salt-induced outer membrane protein
P12B_RS07565	COG0386	Belongs to the glutathione peroxidase family
P12B_RS07575	COG0791	NLP P60 protein
P12B_RS07585	COG2200	EAL domain
P12B_RS07595	COG4256	Hemin uptake protein
P12B_RS07600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P12B_RS07615	COG0574	Belongs to the PEP-utilizing enzyme family
P12B_RS07615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P12B_RS07620	COG0318	PFAM AMP-dependent synthetase and ligase
P12B_RS07625	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
P12B_RS07630	COG0644	oxidoreductase
P12B_RS07635	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
P12B_RS07640	COG2086	electron transfer activity
P12B_RS07650	COG2207	Transcriptional regulator
P12B_RS07650	COG1917	Cupin 2, conserved barrel domain protein
P12B_RS07655	COG1960	acyl-CoA dehydrogenase activity
P12B_RS07660	COG4670	ketone body catabolic process
P12B_RS07680	COG0738	Major facilitator superfamily
P12B_RS07690	COG0628	permease
P12B_RS07695	COG0277	FAD linked oxidase domain protein
P12B_RS07695	COG0247	lactate metabolic process
P12B_RS07700	COG2050	protein possibly involved in aromatic compounds catabolism
P12B_RS07710	COG0316	Belongs to the HesB IscA family
P12B_RS07715	COG0719	Fe-S assembly protein
P12B_RS07720	COG0396	ATPase activity
P12B_RS07725	COG0719	Fe-S assembly protein
P12B_RS07740	COG1376	ErfK ybiS ycfS ynhG family protein
P12B_RS07745	COG4238	major outer membrane lipoprotein
P12B_RS07750	COG0469	pyruvate kinase activity
P12B_RS07765	COG2414	aldehyde ferredoxin oxidoreductase
P12B_RS07775	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS07780	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
P12B_RS07790	COG4529	Protein conserved in bacteria
P12B_RS07810	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS07820	COG0307	riboflavin synthase, alpha
P12B_RS07825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
P12B_RS07830	COG2814	Major facilitator Superfamily
P12B_RS07835	COG0583	DNA-binding transcription factor activity
P12B_RS07850	COG2814	Major facilitator Superfamily
P12B_RS07855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
P12B_RS07860	COG0791	NLP P60 protein
P12B_RS07865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
P12B_RS07880	COG0346	lactoylglutathione lyase activity
P12B_RS07885	COG1902	pentaerythritol trinitrate reductase activity
P12B_RS07890	COG1309	transcriptional regulator
P12B_RS07895	COG3313	Fe-S protein
P12B_RS07900	COG4989	oxidoreductase activity
P12B_RS07905	COG2032	superoxide dismutase activity
P12B_RS07910	COG1289	transmembrane transporter activity
P12B_RS07915	COG1566	PFAM secretion protein HlyD family protein
P12B_RS07930	COG3133	Outer membrane lipoprotein
P12B_RS07940	COG3895	Periplasmic Protein
P12B_RS07955	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
P12B_RS07960	COG0625	glutathione transferase activity
P12B_RS07965	COG3104	oligopeptide transport
P12B_RS07985	COG4659	FMN binding
P12B_RS08025	COG0673	inositol 2-dehydrogenase activity
P12B_RS08035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
P12B_RS08040	COG1263	PTS System
P12B_RS08040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS08055	COG1309	transcriptional regulator
P12B_RS08060	COG3250	beta-galactosidase activity
P12B_RS08080	COG5339	Protein conserved in bacteria
P12B_RS08085	COG1482	cell wall glycoprotein biosynthetic process
P12B_RS08090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
P12B_RS08090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
P12B_RS08095	COG0114	fumarate hydratase activity
P12B_RS08105	COG2205	protein histidine kinase activity
P12B_RS08110	COG0745	RESPONSE REGULATOR receiver
P12B_RS08115	COG3136	membrane protein required for alginate biosynthesis
P12B_RS08125	COG0531	amino acid
P12B_RS08135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
P12B_RS08140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
P12B_RS08145	COG0628	permease
P12B_RS08160	COG3591	Belongs to the peptidase S1B family
P12B_RS08175	COG2814	Major facilitator Superfamily
P12B_RS08180	COG0583	DNA-binding transcription factor activity
P12B_RS08185	COG1940	carbohydrate kinase activity
P12B_RS08190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P12B_RS08200	COG3381	protein complex oligomerization
P12B_RS08205	COG3302	dmso reductase anchor subunit
P12B_RS08210	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS08215	COG0243	molybdopterin cofactor binding
P12B_RS08235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P12B_RS08250	COG4948	Mandelate Racemase Muconate Lactonizing
P12B_RS08255	COG1063	alcohol dehydrogenase
P12B_RS08260	COG0582	viral genome integration into host DNA
P12B_RS08305	COG2801	Transposase and inactivated derivatives
P12B_RS08310	COG3328	transposase activity
P12B_RS08320	COG3077	Addiction module antitoxin, RelB DinJ family
P12B_RS08325	COG2026	Addiction module toxin, RelE StbE family
P12B_RS08345	COG1403	HNH endonuclease
P12B_RS08350	COG0484	heat shock protein binding
P12B_RS08355	COG1278	Cold shock
P12B_RS08360	COG1278	Cold shock
P12B_RS08375	COG3772	lysozyme
P12B_RS08385	COG1278	Cold shock
P12B_RS08400	COG5562	phage envelope protein
P12B_RS08410	COG4220	transposase activity
P12B_RS08440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
P12B_RS08445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
P12B_RS08455	COG0477	Major facilitator Superfamily
P12B_RS08460	COG0246	Mannitol dehydrogenase
P12B_RS08470	COG1802	Transcriptional regulator
P12B_RS08475	COG4221	oxidoreductase activity
P12B_RS08480	COG0339	signal peptide processing
P12B_RS08485	COG1546	Belongs to the CinA family
P12B_RS08490	COG3111	PFAM Bacterial OB fold (BOF) protein
P12B_RS08495	COG3706	GGDEF domain
P12B_RS08505	COG2814	Major facilitator Superfamily
P12B_RS08510	COG0697	spore germination
P12B_RS08520	COG4977	sequence-specific DNA binding
P12B_RS08525	COG1846	Transcriptional regulator
P12B_RS08545	COG0583	DNA-binding transcription factor activity
P12B_RS08550	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS08555	COG2066	Belongs to the glutaminase family
P12B_RS08565	COG2199	diguanylate cyclase activity
P12B_RS08580	COG3781	membrane
P12B_RS08630	COG3210	domain, Protein
P12B_RS08630	COG2911	Protein conserved in bacteria
P12B_RS08655	COG1396	sequence-specific DNA binding
P12B_RS08660	COG3550	peptidyl-serine autophosphorylation
P12B_RS08755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P12B_RS08780	COG2963	transposase activity
P12B_RS08795	COG3436	PFAM IS66 Orf2 family protein
P12B_RS08800	COG4372	Transposase
P12B_RS08810	COG3436	PFAM IS66 Orf2 family protein
P12B_RS08815	COG2433	Pfam Transposase IS66
P12B_RS08820	COG4372	Transposase
P12B_RS08835	COG0598	Magnesium transport protein CorA
P12B_RS08845	COG3698	Phosphodiester glycosidase
P12B_RS08880	COG1662	PFAM IS1 transposase
P12B_RS08900	COG4977	sequence-specific DNA binding
P12B_RS08905	COG3188	usher protein
P12B_RS08910	COG3539	Fimbrial protein
P12B_RS08915	COG3539	Fimbrial protein
P12B_RS08920	COG3539	Fimbrial protein
P12B_RS08925	COG0243	molybdopterin cofactor binding
P12B_RS08940	COG3119	arylsulfatase activity
P12B_RS08945	COG0641	radical SAM
P12B_RS08950	COG4178	(ABC) transporter
P12B_RS08955	COG4771	TonB-dependent receptor
P12B_RS08960	COG0612	Peptidase, M16
P12B_RS08970	COG0076	glutamate decarboxylase activity
P12B_RS08975	COG0531	amino acid
P12B_RS08980	COG1649	PFAM Uncharacterised BCR, COG1649
P12B_RS08985	COG3706	GGDEF domain
P12B_RS08990	COG2202	Pas domain
P12B_RS08990	COG2200	EAL domain
P12B_RS08990	COG2199	diguanylate cyclase activity
P12B_RS08995	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
P12B_RS09000	COG0747	negative chemotaxis
P12B_RS09005	COG0601	transmembrane transport
P12B_RS09010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P12B_RS09015	COG0444	Belongs to the ABC transporter superfamily
P12B_RS09020	COG4608	Belongs to the ABC transporter superfamily
P12B_RS09025	COG1764	response to oxidative stress
P12B_RS09045	COG1064	alcohol dehydrogenase
P12B_RS09050	COG3093	addiction module antidote protein HigA
P12B_RS09055	COG2864	formate dehydrogenase
P12B_RS09060	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS09065	COG0243	molybdopterin cofactor binding
P12B_RS09065	COG3383	formate dehydrogenase (NAD+) activity
P12B_RS09070	COG3383	formate dehydrogenase (NAD+) activity
P12B_RS09070	COG0243	molybdopterin cofactor binding
P12B_RS09075	COG0697	spore germination
P12B_RS09080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
P12B_RS09090	COG2223	nitrite transmembrane transporter activity
P12B_RS09095	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
P12B_RS09100	COG1140	nitrate reductase beta subunit
P12B_RS09105	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
P12B_RS09110	COG2181	nitrate reductase activity
P12B_RS09115	COG0384	phenazine biosynthesis protein PhzF
P12B_RS09120	COG2162	N-hydroxyarylamine O-acetyltransferase activity
P12B_RS09125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P12B_RS09135	COG5433	transposase activity
P12B_RS09140	COG5433	transposase activity
P12B_RS09150	COG3209	COG3209 Rhs family protein
P12B_RS09155	COG3209	COG3209 Rhs family protein
P12B_RS09175	COG1113	amino acid transport
P12B_RS09180	COG3391	amine dehydrogenase activity
P12B_RS09185	COG4772	TonB-dependent receptor
P12B_RS09190	COG1802	Transcriptional regulator
P12B_RS09195	COG2130	NADP-dependent
P12B_RS09200	COG1247	-acetyltransferase
P12B_RS09205	COG3238	Protein conserved in bacteria
P12B_RS09230	COG1177	transmembrane transport
P12B_RS09235	COG1176	ABC-type spermidine putrescine transport system, permease component I
P12B_RS09240	COG3842	ATPase activity
P12B_RS09245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
P12B_RS09250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P12B_RS09255	COG1598	PFAM Uncharacterised protein family UPF0150
P12B_RS09260	COG1724	mRNA binding
P12B_RS09275	COG1396	sequence-specific DNA binding
P12B_RS09280	COG3135	benzoate transporter
P12B_RS09285	COG0675	Transposase, IS605 OrfB family
P12B_RS09310	COG1275	C4-dicarboxylate transporter malic acid transport protein
P12B_RS09315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
P12B_RS09320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P12B_RS09325	COG2841	Protein conserved in bacteria
P12B_RS09340	COG5383	Protein conserved in bacteria
P12B_RS09345	COG0583	DNA-binding transcription factor activity
P12B_RS09365	COG3038	cytochrome b561
P12B_RS09370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P12B_RS09375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P12B_RS09380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P12B_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS09390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
P12B_RS09405	COG2453	phosphatase
P12B_RS09405	COG0671	phosphoesterase, PA-phosphatase related
P12B_RS09410	COG2267	carboxylic ester hydrolase activity
P12B_RS09415	COG4589	Belongs to the CDS family
P12B_RS09420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P12B_RS09430	COG0667	Aldo Keto reductase
P12B_RS09440	COG2433	Pfam Transposase IS66
P12B_RS09445	COG3436	PFAM IS66 Orf2 family protein
P12B_RS09465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
P12B_RS09470	COG3327	negative regulation of DNA-templated transcription, initiation
P12B_RS09475	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
P12B_RS09480	COG0183	Belongs to the thiolase family
P12B_RS09485	COG2050	protein possibly involved in aromatic compounds catabolism
P12B_RS09490	COG1250	3-hydroxyacyl-CoA dehydrogenase
P12B_RS09495	COG1024	Enoyl-CoA hydratase
P12B_RS09500	COG1024	Enoyl-CoA hydratase
P12B_RS09505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P12B_RS09510	COG2151	metal-sulfur cluster biosynthetic enzyme
P12B_RS09515	COG3396	Phenylacetate-CoA oxygenase
P12B_RS09520	COG3460	Phenylacetate-CoA oxygenase
P12B_RS09525	COG3396	Phenylacetate-CoA oxygenase
P12B_RS09530	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS09530	COG2030	dehydratase
P12B_RS09535	COG3733	amine oxidase
P12B_RS09540	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS09545	COG2207	Transcriptional regulator
P12B_RS09550	COG3784	Protein of unknown function (DUF1318)
P12B_RS09560	COG2911	Protein conserved in bacteria
P12B_RS09565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
P12B_RS09570	COG3187	Heat shock protein
P12B_RS09575	COG3042	response to heat
P12B_RS09580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
P12B_RS09580	COG1013	pyruvate-flavodoxin oxidoreductase activity
P12B_RS09580	COG0674	pyruvate-flavodoxin oxidoreductase activity
P12B_RS09580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P12B_RS09585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
P12B_RS09590	COG0589	response to stress
P12B_RS09600	COG0513	Belongs to the DEAD box helicase family
P12B_RS09620	COG2840	Smr protein MutS2
P12B_RS09630	COG0583	DNA-binding transcription factor activity
P12B_RS09635	COG1473	amidohydrolase
P12B_RS09640	COG1473	amidohydrolase
P12B_RS09655	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
P12B_RS09660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
P12B_RS09665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P12B_RS09670	COG0589	response to stress
P12B_RS09675	COG3182	Iron-regulated membrane protein
P12B_RS09680	COG0668	transmembrane transport
P12B_RS09685	COG4166	transmembrane transport
P12B_RS09700	COG1073	alpha beta
P12B_RS09705	COG0702	epimerase
P12B_RS09710	COG2866	Carboxypeptidase
P12B_RS09715	COG4948	Mandelate Racemase Muconate Lactonizing
P12B_RS09720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
P12B_RS09725	COG3283	Transcriptional regulator of aromatic amino acids metabolism
P12B_RS09735	COG3106	COG3106 Predicted ATPase
P12B_RS09740	COG1609	Transcriptional regulator
P12B_RS09750	COG3842	ATPase activity
P12B_RS09760	COG1554	hydrolase, family 65, central catalytic
P12B_RS09765	COG0673	inositol 2-dehydrogenase activity
P12B_RS09770	COG1082	Xylose isomerase domain protein TIM barrel
P12B_RS09775	COG1063	alcohol dehydrogenase
P12B_RS09780	COG0395	ABC-type sugar transport system, permease component
P12B_RS09785	COG1175	transmembrane transport
P12B_RS09790	COG1653	transport
P12B_RS09795	COG0366	Alpha amylase catalytic
P12B_RS09800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P12B_RS09810	COG1983	PspC domain protein
P12B_RS09820	COG1842	Phage shock protein A
P12B_RS09825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
P12B_RS09830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
P12B_RS09835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P12B_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS09845	COG1917	Cupin 2, conserved barrel domain protein
P12B_RS09845	COG1396	sequence-specific DNA binding
P12B_RS09850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
P12B_RS09855	COG0174	glutamine synthetase
P12B_RS09860	COG0531	amino acid
P12B_RS09875	COG4166	transmembrane transport
P12B_RS09880	COG4168	peptide transport system, permease
P12B_RS09885	COG4171	peptide transport system, permease
P12B_RS09890	COG4172	Belongs to the ABC transporter superfamily
P12B_RS09895	COG4172	Belongs to the ABC transporter superfamily
P12B_RS09900	COG2852	Protein conserved in bacteria
P12B_RS09910	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P12B_RS09915	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
P12B_RS09915	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
P12B_RS09940	COG1349	DNA-binding transcription factor activity
P12B_RS09950	COG0023	Translation Initiation Factor
P12B_RS09960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
P12B_RS09965	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
P12B_RS09970	COG0671	phosphoesterase, PA-phosphatase related
P12B_RS09980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
P12B_RS10005	COG0583	DNA-binding transcription factor activity
P12B_RS10010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P12B_RS10025	COG0616	signal peptide processing
P12B_RS10035	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS10040	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
P12B_RS10045	COG1187	pseudouridine synthase activity
P12B_RS10050	COG4907	membrane protein (DUF2207)
P12B_RS10055	COG0009	L-threonylcarbamoyladenylate synthase
P12B_RS10060	COG0613	PHP domain protein
P12B_RS10065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P12B_RS10070	COG0512	Glutamine amidotransferase of anthranilate synthase
P12B_RS10070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P12B_RS10075	COG0134	indole-3-glycerol-phosphate synthase activity
P12B_RS10075	COG0135	phosphoribosylanthranilate isomerase activity
P12B_RS10090	COG3729	General stress protein
P12B_RS10095	COG3685	Protein conserved in bacteria
P12B_RS10100	COG3685	Protein conserved in bacteria
P12B_RS10105	COG3047	cAMP biosynthetic process
P12B_RS10120	COG1607	acyl-coa hydrolase
P12B_RS10125	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
P12B_RS10130	COG2350	Protein conserved in bacteria
P12B_RS10135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
P12B_RS10150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
P12B_RS10275	COG1783	phage Terminase large subunit
P12B_RS10300	COG3772	lysozyme
P12B_RS10320	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
P12B_RS10375	COG0305	Participates in initiation and elongation during chromosome replication
P12B_RS10395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P12B_RS10425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P12B_RS10435	COG0629	single-stranded DNA binding
P12B_RS10445	COG0338	D12 class N6 adenine-specific DNA methyltransferase
P12B_RS10465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
P12B_RS10485	COG4608	Belongs to the ABC transporter superfamily
P12B_RS10490	COG0444	Belongs to the ABC transporter superfamily
P12B_RS10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P12B_RS10500	COG0601	transmembrane transport
P12B_RS10505	COG4166	transmembrane transport
P12B_RS10510	COG2095	MarC family integral membrane protein
P12B_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS10515	COG1454	alcohol dehydrogenase
P12B_RS10530	COG1435	thymidine kinase activity
P12B_RS10540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
P12B_RS10545	COG0745	RESPONSE REGULATOR receiver
P12B_RS10550	COG1752	Esterase of the alpha-beta hydrolase superfamily
P12B_RS10560	COG0788	formyltetrahydrofolate deformylase activity
P12B_RS10580	COG2181	nitrate reductase activity
P12B_RS10585	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
P12B_RS10590	COG1140	nitrate reductase beta subunit
P12B_RS10595	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
P12B_RS10610	COG3850	Histidine kinase
P12B_RS10615	COG2197	response regulator
P12B_RS10620	COG4932	domain protein
P12B_RS10625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
P12B_RS10630	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
P12B_RS10635	COG4572	Cation transport regulator
P12B_RS10640	COG0387	Pfam Sodium calcium exchanger
P12B_RS10660	COG2912	Transglutaminase-like superfamily
P12B_RS10665	COG3094	Invasion gene expression up-regulator, SirB
P12B_RS10670	COG2890	protein-(glutamine-N5) methyltransferase activity
P12B_RS10695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
P12B_RS10700	COG0659	secondary active sulfate transmembrane transporter activity
P12B_RS10715	COG0012	GTP binding
P12B_RS10725	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS10730	COG3284	Transcriptional regulator
P12B_RS10735	COG2376	Dihydroxyacetone kinase
P12B_RS10740	COG1461	Dihydroxyacetone kinase
P12B_RS10745	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
P12B_RS10745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P12B_RS10745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS10760	COG2261	transglycosylase associated protein
P12B_RS10765	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
P12B_RS10775	COG1619	proteins homologs of microcin C7 resistance protein MccF
P12B_RS10785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
P12B_RS10795	COG2719	SpoVR family
P12B_RS10810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
P12B_RS10815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
P12B_RS10820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P12B_RS10835	COG0179	Fumarylacetoacetate (FAA) hydrolase
P12B_RS10860	COG2894	cell division
P12B_RS10890	COG1662	PFAM IS1 transposase
P12B_RS10895	COG2200	EAL domain
P12B_RS10900	COG0789	Transcriptional regulator
P12B_RS10905	COG5562	phage envelope protein
P12B_RS10910	COG1662	PFAM IS1 transposase
P12B_RS10915	COG5562	phage envelope protein
P12B_RS10930	COG0538	isocitrate dehydrogenase activity
P12B_RS10935	COG1187	pseudouridine synthase activity
P12B_RS10955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
P12B_RS10960	COG0745	RESPONSE REGULATOR receiver
P12B_RS10965	COG2205	protein histidine kinase activity
P12B_RS10970	COG2850	peptidyl-arginine hydroxylation
P12B_RS10985	COG3842	ATPase activity
P12B_RS10995	COG1177	transmembrane transport
P12B_RS11000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
P12B_RS11010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
P12B_RS11015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
P12B_RS11025	COG4591	ABC-type transport system involved in lipoprotein release permease component
P12B_RS11030	COG1136	(ABC) transporter
P12B_RS11035	COG4591	ABC-type transport system involved in lipoprotein release permease component
P12B_RS11040	COG4763	Acyl-transferase
P12B_RS11045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P12B_RS11050	COG1388	LysM domain
P12B_RS11050	COG1376	ErfK ybiS ycfS ynhG family protein
P12B_RS11060	COG1309	transcriptional regulator
P12B_RS11065	COG3134	Outer membrane lipoprotein
P12B_RS11070	COG1252	NADH dehydrogenase
P12B_RS11090	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
P12B_RS11095	COG5633	Lipoprotein
P12B_RS11100	COG0537	adenosine 5'-monophosphoramidase activity
P12B_RS11105	COG4773	Receptor
P12B_RS11115	COG0084	hydrolase, TatD family'
P12B_RS11120	COG0470	DNA polymerase III
P12B_RS11130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
P12B_RS11135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P12B_RS11140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P12B_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS11155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
P12B_RS11175	COG1399	metal-binding, possibly nucleic acid-binding protein
P12B_RS11185	COG0564	pseudouridine synthase activity
P12B_RS11200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
P12B_RS11205	COG1256	bacterial-type flagellum assembly
P12B_RS11210	COG1705	Flagellar rod assembly protein muramidase FlgJ
P12B_RS11210	COG3951	Flagellar rod assembly protein muramidase FlgJ
P12B_RS11225	COG4786	Flagellar basal body rod
P12B_RS11230	COG4787	bacterial-type flagellum-dependent cell motility
P12B_RS11235	COG1749	Flagellar hook protein flgE
P12B_RS11240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
P12B_RS11245	COG1558	bacterial-type flagellum-dependent cell motility
P12B_RS11250	COG1815	bacterial-type flagellum-dependent cell motility
P12B_RS11255	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
P12B_RS11260	COG2747	anti-sigma28 factor FlgM
P12B_RS11270	COG0728	peptidoglycan biosynthetic process
P12B_RS11275	COG0673	inositol 2-dehydrogenase activity
P12B_RS11285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P12B_RS11295	COG2999	glutathione oxidoreductase activity
P12B_RS11330	COG3038	cytochrome b561
P12B_RS11335	COG2353	YceI-like domain
P12B_RS11345	COG1560	Kdo2-lipid A biosynthetic process
P12B_RS11365	COG5645	(Lipo)protein
P12B_RS11370	COG2943	transferase activity, transferring hexosyl groups
P12B_RS11395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P12B_RS11400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
P12B_RS11435	COG2197	response regulator
P12B_RS11450	COG1462	curli production assembly transport component CsgG
P12B_RS11460	COG3381	protein complex oligomerization
P12B_RS11500	COG2801	Transposase and inactivated derivatives
P12B_RS11505	COG2826	transposase and inactivated derivatives, IS30 family
P12B_RS11520	COG1735	metal-dependent hydrolase with the TIM-barrel fold
P12B_RS11525	COG0405	Gamma-glutamyltransferase
P12B_RS11650	COG2003	Belongs to the UPF0758 family
P12B_RS11680	COG4372	Transposase
P12B_RS11695	COG1289	transmembrane transporter activity
P12B_RS11705	COG1686	Belongs to the peptidase S11 family
P12B_RS11710	COG2925	Exonuclease
P12B_RS11715	COG0425	Belongs to the sulfur carrier protein TusA family
P12B_RS11720	COG2391	methyltransferase activity
P12B_RS11725	COG0531	amino acid
P12B_RS11730	COG0583	DNA-binding transcription factor activity
P12B_RS11735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P12B_RS11740	COG4115	mRNA cleavage
P12B_RS11745	COG2161	toxin-antitoxin pair type II binding
P12B_RS11755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
P12B_RS11765	COG0131	Imidazoleglycerol-phosphate dehydratase
P12B_RS11765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
P12B_RS11770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P12B_RS11790	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
P12B_RS11795	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P12B_RS11800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
P12B_RS11840	COG2244	polysaccharide biosynthetic process
P12B_RS11845	COG5433	transposase activity
P12B_RS11850	COG5433	transposase activity
P12B_RS11855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
P12B_RS11865	COG0438	transferase activity, transferring glycosyl groups
P12B_RS11870	COG2327	Polysaccharide pyruvyl transferase
P12B_RS11880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
P12B_RS11885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P12B_RS11890	COG0662	Cupin 2, conserved barrel domain protein
P12B_RS11890	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
P12B_RS11895	COG0297	glycogen (starch) synthase activity
P12B_RS11900	COG1051	belongs to the nudix hydrolase family
P12B_RS11905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P12B_RS11910	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
P12B_RS11915	COG0110	maltose O-acetyltransferase activity
P12B_RS11920	COG1216	Glycosyl transferase, family 2
P12B_RS11930	COG0438	transferase activity, transferring glycosyl groups
P12B_RS11935	COG1045	serine acetyltransferase
P12B_RS11940	COG0463	Glycosyl transferase, family 2
P12B_RS11945	COG3206	protein involved in exopolysaccharide biosynthesis
P12B_RS11945	COG0489	protein tyrosine kinase activity
P12B_RS11950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P12B_RS11955	COG1596	polysaccharide export
P12B_RS11965	COG2982	Protein involved in outer membrane biogenesis
P12B_RS11975	COG0572	uridine kinase
P12B_RS11980	COG5001	Diguanylate cyclase
P12B_RS11980	COG3447	MASE1 domain protein
P12B_RS11980	COG5002	protein histidine kinase activity
P12B_RS11985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
P12B_RS11990	COG0443	Heat shock 70 kDa protein
P12B_RS11995	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
P12B_RS12000	COG0631	protein serine/threonine phosphatase activity
P12B_RS12005	COG4245	von Willebrand factor, type A
P12B_RS12030	COG2205	protein histidine kinase activity
P12B_RS12035	COG0745	RESPONSE REGULATOR receiver
P12B_RS12045	COG0826	peptidase U32
P12B_RS12070	COG1063	alcohol dehydrogenase
P12B_RS12075	COG3775	system Galactitol-specific IIC component
P12B_RS12080	COG3414	Phosphotransferase system galactitol-specific IIB component
P12B_RS12085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS12100	COG1830	Aldolase
P12B_RS12105	COG2211	Major facilitator Superfamily
P12B_RS12110	COG1397	ADP-ribosylglycohydrolase
P12B_RS12115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS12120	COG2188	Transcriptional regulator
P12B_RS12125	COG3757	hydrolase, family 25
P12B_RS12130	COG0351	phosphomethylpyrimidine kinase
P12B_RS12145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
P12B_RS12150	COG5455	response to cobalt ion
P12B_RS12155	COG3539	Fimbrial protein
P12B_RS12160	COG3188	usher protein
P12B_RS12165	COG3188	usher protein
P12B_RS12170	COG3121	Chaperone
P12B_RS12175	COG3539	Fimbrial protein
P12B_RS12190	COG0489	protein tyrosine kinase activity
P12B_RS12205	COG3831	ATPase activity
P12B_RS12210	COG3831	ATPase activity
P12B_RS12220	COG0714	Associated with various cellular activities
P12B_RS12230	COG2425	protein containing a von Willebrand factor type A (vWA) domain
P12B_RS12235	COG3552	Protein containing von Willebrand factor type A (VWA) domain
P12B_RS12240	COG4715	Zinc finger, swim domain protein
P12B_RS12245	COG4808	Protein conserved in bacteria
P12B_RS12250	COG4807	Protein conserved in bacteria
P12B_RS12255	COG3279	Response regulator of the LytR AlgR family
P12B_RS12260	COG3275	phosphorelay sensor kinase activity
P12B_RS12275	COG1174	glycine betaine transport
P12B_RS12280	COG1125	glycine betaine transport
P12B_RS12285	COG1174	glycine betaine transport
P12B_RS12290	COG1732	Glycine betaine
P12B_RS12295	COG1472	Belongs to the glycosyl hydrolase 3 family
P12B_RS12300	COG0277	FAD linked oxidase domain protein
P12B_RS12305	COG1686	Belongs to the peptidase S11 family
P12B_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS12335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P12B_RS12345	COG1346	cytolysis
P12B_RS12355	COG2949	membrane
P12B_RS12365	COG0493	'glutamate synthase
P12B_RS12370	COG0167	dihydroorotate dehydrogenase activity
P12B_RS12370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
P12B_RS12375	COG4211	Belongs to the binding-protein-dependent transport system permease family
P12B_RS12380	COG1129	ABC transporter
P12B_RS12385	COG1879	ABC-type sugar transport system periplasmic component
P12B_RS12390	COG1609	Transcriptional regulator
P12B_RS12400	COG2311	Membrane
P12B_RS12420	COG4771	TonB-dependent receptor
P12B_RS12425	COG0833	amino acid
P12B_RS12430	COG0583	DNA-binding transcription factor activity
P12B_RS12435	COG2855	membrane
P12B_RS12445	COG1522	sequence-specific DNA binding
P12B_RS12445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS12450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
P12B_RS12460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P12B_RS12465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
P12B_RS12470	COG2313	pseudouridylate synthase activity
P12B_RS12475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS12480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS12480	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
P12B_RS12480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS12485	COG1105	Belongs to the carbohydrate kinase PfkB family
P12B_RS12490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS12490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS12495	COG2814	Major facilitator Superfamily
P12B_RS12515	COG0523	cobalamin synthesis protein
P12B_RS12520	COG0671	phosphoesterase, PA-phosphatase related
P12B_RS12525	COG0791	NLP P60 protein
P12B_RS12530	COG2200	EAL domain
P12B_RS12535	COG4166	transmembrane transport
P12B_RS12540	COG4174	ABC transporter (Permease)
P12B_RS12545	COG4239	(ABC) transporter, permease
P12B_RS12550	COG4172	Belongs to the ABC transporter superfamily
P12B_RS12560	COG2814	Major facilitator Superfamily
P12B_RS12565	COG1187	pseudouridine synthase activity
P12B_RS12570	COG1061	Type III restriction enzyme res subunit
P12B_RS12590	COG3083	sulfuric ester hydrolase activity
P12B_RS12600	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS12610	COG2197	response regulator
P12B_RS12615	COG4235	cytochrome complex assembly
P12B_RS12615	COG3088	subunit of a heme lyase
P12B_RS12620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P12B_RS12625	COG1138	Cytochrome C-type biogenesis protein
P12B_RS12635	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P12B_RS12640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P12B_RS12645	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P12B_RS12650	COG4133	protoheme IX ABC transporter activity
P12B_RS12655	COG3005	denitrification pathway
P12B_RS12660	COG3043	anaerobic respiration
P12B_RS12665	COG0348	domain, Protein
P12B_RS12670	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS12680	COG3062	negative regulation of establishment of protein localization
P12B_RS12685	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS12685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS12705	COG4615	Cyclic peptide transporter
P12B_RS12710	COG3145	DNA-N1-methyladenine dioxygenase activity
P12B_RS12720	COG1477	protein flavinylation
P12B_RS12725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
P12B_RS12740	COG0642	Histidine kinase
P12B_RS12740	COG2198	Histidine kinase
P12B_RS12745	COG2197	response regulator
P12B_RS12750	COG0784	Response regulator, receiver
P12B_RS12750	COG2205	protein histidine kinase activity
P12B_RS12760	COG2204	response regulator
P12B_RS12765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
P12B_RS12770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
P12B_RS12780	COG0183	Belongs to the thiolase family
P12B_RS12785	COG4676	Protein conserved in bacteria
P12B_RS12790	COG5445	Predicted secreted protein (DUF2300)
P12B_RS12800	COG3234	Protein of unknown function (DUF1175)
P12B_RS12805	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
P12B_RS12810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P12B_RS12820	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS12830	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS12840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P12B_RS12845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P12B_RS12850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P12B_RS12855	COG3642	lipopolysaccharide core region biosynthetic process
P12B_RS12860	COG0583	DNA-binding transcription factor activity
P12B_RS12865	COG0584	glycerophosphoryl diester phosphodiesterase
P12B_RS12870	COG2271	Major facilitator Superfamily
P12B_RS12875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
P12B_RS12890	COG5464	transposase or invertase
P12B_RS12905	COG2271	Major facilitator Superfamily
P12B_RS12915	COG1414	Transcriptional regulator
P12B_RS12980	COG0318	PFAM AMP-dependent synthetase and ligase
P12B_RS12990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
P12B_RS13005	COG1169	isochorismate synthase
P12B_RS13010	COG4575	ribosome binding
P12B_RS13015	COG2153	protein acetylation
P12B_RS13025	COG5160	protein modification by small protein removal
P12B_RS13030	COG2304	oxidoreductase activity
P12B_RS13035	COG2234	aminopeptidase activity
P12B_RS13055	COG0457	Tetratricopeptide repeat
P12B_RS13065	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P12B_RS13070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P12B_RS13080	COG0839	Belongs to the complex I subunit 6 family
P12B_RS13095	COG1034	ATP synthesis coupled electron transport
P12B_RS13100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
P12B_RS13105	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
P12B_RS13125	COG0583	DNA-binding transcription factor activity
P12B_RS13130	COG0436	Aminotransferase
P12B_RS13140	COG0471	metal ion transport
P12B_RS13140	COG0490	domain, Protein
P12B_RS13145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
P12B_RS13165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
P12B_RS13170	COG0280	phosphate acetyltransferase
P12B_RS13170	COG0857	belongs to the CobB CobQ family
P12B_RS13175	COG1288	antiporter activity
P12B_RS13180	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
P12B_RS13185	COG0622	Phosphoesterase
P12B_RS13190	COG0625	glutathione transferase activity
P12B_RS13195	COG0625	glutathione transferase activity
P12B_RS13200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P12B_RS13205	COG1090	epimerase
P12B_RS13210	COG5464	transposase or invertase
P12B_RS13215	COG4598	ABC transporter
P12B_RS13220	COG4160	amino acid transport
P12B_RS13225	COG4215	(ABC) transporter
P12B_RS13230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS13235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS13240	COG0163	prenyltransferase activity
P12B_RS13245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
P12B_RS13250	COG1286	toxin biosynthetic process
P12B_RS13255	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
P12B_RS13260	COG0285	dihydrofolate synthase activity
P12B_RS13270	COG0586	Pfam SNARE associated Golgi protein
P12B_RS13280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P12B_RS13295	COG2814	Major facilitator Superfamily
P12B_RS13300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P12B_RS13315	COG3101	peptidyl-lysine hydroxylation
P12B_RS13320	COG0730	response to heat
P12B_RS13335	COG2890	protein-(glutamine-N5) methyltransferase activity
P12B_RS13345	COG1662	PFAM IS1 transposase
P12B_RS13350	COG3385	transposase activity
P12B_RS13360	COG3539	Fimbrial protein
P12B_RS13365	COG3539	Fimbrial protein
P12B_RS13370	COG3539	Fimbrial protein
P12B_RS13375	COG3121	Chaperone
P12B_RS13380	COG3188	usher protein
P12B_RS13385	COG3539	Fimbrial protein
P12B_RS13390	COG2062	phosphohistidine phosphatase, SixA
P12B_RS13405	COG3691	Protein conserved in bacteria
P12B_RS13410	COG2067	long-chain fatty acid transport protein
P12B_RS13420	COG2853	Lipoprotein
P12B_RS13425	COG2116	formate transmembrane transporter activity
P12B_RS13435	COG0582	viral genome integration into host DNA
P12B_RS13685	COG3723	Recombinational DNA repair protein, rece pathway
P12B_RS13750	COG0583	DNA-binding transcription factor activity
P12B_RS13755	COG2610	gluconate transmembrane transporter activity
P12B_RS13765	COG0477	Major facilitator Superfamily
P12B_RS13770	COG1566	PFAM secretion protein HlyD family protein
P12B_RS13775	COG2197	response regulator
P12B_RS13780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS13780	COG2205	protein histidine kinase activity
P12B_RS13780	COG2198	Histidine kinase
P12B_RS13780	COG0784	Response regulator, receiver
P12B_RS13785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
P12B_RS13790	COG0679	Auxin Efflux Carrier
P12B_RS13795	COG0028	Belongs to the TPP enzyme family
P12B_RS13830	COG1560	Kdo2-lipid A biosynthetic process
P12B_RS13840	COG0436	Aminotransferase
P12B_RS13845	COG3275	phosphorelay sensor kinase activity
P12B_RS13850	COG3279	Response regulator of the LytR AlgR family
P12B_RS13855	COG2207	Transcriptional regulator
P12B_RS13860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS13860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS13860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P12B_RS13865	COG1363	Peptidase, m42
P12B_RS13870	COG0006	proline dipeptidase activity
P12B_RS13875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS13880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS13910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
P12B_RS13915	COG2200	EAL domain
P12B_RS13915	COG2199	diguanylate cyclase activity
P12B_RS13930	COG3415	Transposase
P12B_RS13935	COG3415	Transposase
P12B_RS13965	COG0583	DNA-binding transcription factor activity
P12B_RS13975	COG2211	Major facilitator Superfamily
P12B_RS13980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
P12B_RS13990	COG0583	DNA-binding transcription factor activity
P12B_RS13995	COG0385	Bile acid
P12B_RS14000	COG3530	Putative quorum-sensing-regulated virulence factor
P12B_RS14020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P12B_RS14025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS14030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P12B_RS14035	COG2190	(PTS) system
P12B_RS14050	COG4884	unkown
P12B_RS14050	COG3831	ATPase activity
P12B_RS14055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P12B_RS14060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
P12B_RS14065	COG4208	sulfate ABC transporter
P12B_RS14070	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
P12B_RS14075	COG4150	thiosulfate binding
P12B_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS14095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS14095	COG1263	PTS System
P12B_RS14100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
P12B_RS14105	COG2837	iron assimilation
P12B_RS14120	COG0456	acetyltransferase
P12B_RS14125	COG0860	N-Acetylmuramoyl-L-alanine amidase
P12B_RS14135	COG2207	Transcriptional regulator
P12B_RS14140	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
P12B_RS14145	COG4816	utilization protein
P12B_RS14155	COG4303	Ethanolamine ammonia lyase large subunit
P12B_RS14160	COG4819	ethanolamine utilization protein
P12B_RS14165	COG3192	ethanolamine utilization protein
P12B_RS14170	COG1454	alcohol dehydrogenase
P12B_RS14175	COG4820	ethanolamine utilization protein (EutJ)
P12B_RS14180	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS14185	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
P12B_RS14190	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
P12B_RS14195	COG0280	phosphate acetyltransferase
P12B_RS14200	COG4812	Cobalamin adenosyltransferase
P12B_RS14205	COG4766	ethanolamine catabolic process
P12B_RS14210	COG4917	ethanolamine utilization protein
P12B_RS14215	COG4810	utilization protein
P12B_RS14220	COG0281	malic enzyme
P12B_RS14220	COG0280	phosphate acetyltransferase
P12B_RS14225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P12B_RS14230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P12B_RS14235	COG5342	invasion associated locus B
P12B_RS14245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS14245	COG0493	'glutamate synthase
P12B_RS14250	COG3850	Histidine kinase
P12B_RS14255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P12B_RS14265	COG1393	Belongs to the ArsC family
P12B_RS14280	COG0400	carboxylic ester hydrolase activity
P12B_RS14285	COG1444	tRNA N-acetyltransferase activity
P12B_RS14290	COG2321	neutral zinc metallopeptidase
P12B_RS14305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
P12B_RS14315	COG2716	regulation of RNA biosynthetic process
P12B_RS14320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P12B_RS14325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS14330	COG0651	ATP synthesis coupled electron transport
P12B_RS14335	COG0650	Formate hydrogenlyase subunit 4
P12B_RS14340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P12B_RS14345	COG4237	Hydrogenase 4 membrane
P12B_RS14355	COG3261	NADH dehydrogenase
P12B_RS14355	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
P12B_RS14360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P12B_RS14365	COG3260	NADH ubiquinone oxidoreductase 20
P12B_RS14375	COG3604	Transcriptional regulator
P12B_RS14380	COG2116	formate transmembrane transporter activity
P12B_RS14385	COG0628	permease
P12B_RS14390	COG4783	chaperone-mediated protein folding
P12B_RS14395	COG1393	Belongs to the ArsC family
P12B_RS14405	COG2233	PERMEase
P12B_RS14420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P12B_RS14425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
P12B_RS14430	COG0248	Ppx GppA phosphatase
P12B_RS14435	COG2200	EAL domain
P12B_RS14450	COG3133	Outer membrane lipoprotein
P12B_RS14465	COG0517	IMP dehydrogenase activity
P12B_RS14465	COG0516	GMP reductase activity
P12B_RS14475	COG1645	bacterial-type flagellum-dependent swarming motility
P12B_RS14490	COG2976	Protein conserved in bacteria
P12B_RS14520	COG4953	penicillin-binding protein 1C
P12B_RS14525	COG2373	Large extracellular alpha-helical protein
P12B_RS14530	COG2897	thiosulfate sulfurtransferase activity
P12B_RS14545	COG2975	iron-sulfur cluster assembly
P12B_RS14550	COG0633	Ferredoxin
P12B_RS14570	COG0822	iron-sulfur transferase activity
P12B_RS14590	COG0483	inositol monophosphate 1-phosphatase activity
P12B_RS14595	COG1073	alpha beta
P12B_RS14600	COG3711	transcriptional antiterminator
P12B_RS14605	COG2814	Major facilitator Superfamily
P12B_RS14610	COG0583	DNA-binding transcription factor activity
P12B_RS14615	COG4638	Rieske (2fe-2S)
P12B_RS14640	COG1662	PFAM IS1 transposase
P12B_RS14645	COG2259	Doxx family
P12B_RS14650	COG2017	converts alpha-aldose to the beta-anomer
P12B_RS14655	COG1063	alcohol dehydrogenase
P12B_RS14660	COG1172	Belongs to the binding-protein-dependent transport system permease family
P12B_RS14665	COG1129	ABC transporter
P12B_RS14670	COG1879	ABC-type sugar transport system periplasmic component
P12B_RS14675	COG0457	Tetratricopeptide repeat
P12B_RS14680	COG1940	carbohydrate kinase activity
P12B_RS14690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P12B_RS14690	COG1017	nitric oxide dioxygenase activity
P12B_RS14695	COG0347	Belongs to the P(II) protein family
P12B_RS14700	COG2204	response regulator
P12B_RS14705	COG3170	Tfp pilus assembly protein FimV
P12B_RS14710	COG2205	protein histidine kinase activity
P12B_RS14715	COG0047	phosphoribosylformylglycinamidine synthase activity
P12B_RS14715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P12B_RS14730	COG0560	Phosphoserine phosphatase
P12B_RS14735	COG1737	Transcriptional regulator
P12B_RS14740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS14765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
P12B_RS14785	COG0681	Belongs to the peptidase S26 family
P12B_RS14795	COG3086	response to oxidative stress
P12B_RS14800	COG3026	antisigma factor binding
P12B_RS14805	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
P12B_RS14810	COG1595	DNA-templated transcription, initiation
P12B_RS14820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
P12B_RS14830	COG0513	Belongs to the DEAD box helicase family
P12B_RS14840	COG0583	DNA-binding transcription factor activity
P12B_RS14860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P12B_RS14870	COG3118	belongs to the thioredoxin family
P12B_RS14875	COG3148	PFAM DTW domain containing protein
P12B_RS14880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
P12B_RS14880	COG1042	CoA-binding domain protein
P12B_RS14880	COG0045	succinate-CoA ligase (ADP-forming) activity
P12B_RS14885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P12B_RS14890	COG5544	Lipoprotein
P12B_RS14895	COG0477	Major facilitator Superfamily
P12B_RS14925	COG0542	response to heat
P12B_RS14935	COG0564	pseudouridine synthase activity
P12B_RS14940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P12B_RS14950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
P12B_RS14955	COG1605	Chorismate mutase
P12B_RS14955	COG0077	Prephenate dehydratase
P12B_RS14960	COG1605	Chorismate mutase
P12B_RS14960	COG0287	Prephenate dehydrogenase
P12B_RS14965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P12B_RS14980	COG2199	diguanylate cyclase activity
P12B_RS14985	COG2885	chlorophyll binding
P12B_RS15010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P12B_RS15015	COG4137	Cytochrome C assembly protein
P12B_RS15040	COG0497	DNA recombination
P12B_RS15045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P12B_RS15055	COG2867	negative regulation of translational initiation
P12B_RS15110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
P12B_RS15125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
P12B_RS15250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P12B_RS15285	COG4974	Belongs to the 'phage' integrase family
P12B_RS15300	COG0582	viral genome integration into host DNA
P12B_RS15370	COG2801	Transposase and inactivated derivatives
P12B_RS15375	COG0366	Alpha amylase catalytic
P12B_RS15380	COG0366	Alpha amylase catalytic
P12B_RS15385	COG0366	Alpha amylase catalytic
P12B_RS15395	COG0579	oxidoreductase
P12B_RS15400	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS15405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
P12B_RS15410	COG1113	amino acid transport
P12B_RS15415	COG1802	Transcriptional regulator
P12B_RS15420	COG1652	LysM domain
P12B_RS15425	COG0401	homolog of Blt101
P12B_RS15430	COG0640	Transcriptional regulator
P12B_RS15435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P12B_RS15440	COG2916	Histone family protein nucleoid-structuring protein H-NS
P12B_RS15455	COG4575	ribosome binding
P12B_RS15460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P12B_RS15470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P12B_RS15480	COG4175	Glycine betaine
P12B_RS15485	COG4176	ABC-type proline glycine betaine transport system permease component
P12B_RS15490	COG2113	Glycine betaine
P12B_RS15495	COG2814	Major facilitator Superfamily
P12B_RS15500	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
P12B_RS15510	COG1846	Transcriptional regulator
P12B_RS15515	COG1566	PFAM secretion protein HlyD family protein
P12B_RS15520	COG2814	Major facilitator Superfamily
P12B_RS15540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
P12B_RS15565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
P12B_RS15590	COG1546	Belongs to the CinA family
P12B_RS15595	COG2951	lytic endotransglycosylase activity
P12B_RS15600	COG3730	PTS system glucitol sorbitol-specific
P12B_RS15605	COG3732	PTS system glucitol sorbitol-specific
P12B_RS15610	COG3731	PTS system glucitol sorbitol-specific IIA component
P12B_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS15625	COG1349	DNA-binding transcription factor activity
P12B_RS15630	COG0517	IMP dehydrogenase activity
P12B_RS15630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
P12B_RS15650	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
P12B_RS15655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS15660	COG1609	Transcriptional regulator
P12B_RS15665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS15665	COG1263	PTS System
P12B_RS15670	COG2723	6-phospho-beta-galactosidase activity
P12B_RS15675	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
P12B_RS15690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P12B_RS15695	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
P12B_RS15695	COG3261	NADH dehydrogenase
P12B_RS15700	COG0650	Formate hydrogenlyase subunit 4
P12B_RS15705	COG0651	ATP synthesis coupled electron transport
P12B_RS15710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS15725	COG0375	protein maturation
P12B_RS15730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
P12B_RS15735	COG0298	carbon dioxide binding
P12B_RS15740	COG0409	Hydrogenase expression formation protein
P12B_RS15745	COG0309	Hydrogenase expression formation protein (HypE)
P12B_RS15750	COG3604	Transcriptional regulator
P12B_RS15765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
P12B_RS15770	COG1349	DNA-binding transcription factor activity
P12B_RS15775	COG2084	Dehydrogenase
P12B_RS15780	COG3395	kinase activity
P12B_RS15785	COG0235	Class ii aldolase
P12B_RS15790	COG3622	Belongs to the hyi family
P12B_RS15795	COG2610	gluconate transmembrane transporter activity
P12B_RS15800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P12B_RS15805	COG4942	peptidase
P12B_RS15805	COG1388	LysM domain
P12B_RS15860	COG2234	aminopeptidase activity
P12B_RS15865	COG3385	transposase activity
P12B_RS15880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P12B_RS15890	COG0720	synthase
P12B_RS15895	COG0644	oxidoreductase
P12B_RS15900	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
P12B_RS15905	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
P12B_RS15910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
P12B_RS15915	COG2086	electron transfer activity
P12B_RS15920	COG0477	Major facilitator Superfamily
P12B_RS15925	COG0277	FAD linked oxidase domain protein
P12B_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS15935	COG2223	nitrite transmembrane transporter activity
P12B_RS15940	COG1070	Carbohydrate kinase
P12B_RS15945	COG0602	queuosine metabolic process
P12B_RS15955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
P12B_RS15970	COG3956	TIGRFAM MazG family protein
P12B_RS15975	COG2337	Toxic component of a toxin-antitoxin (TA) module
P12B_RS15980	COG2336	PFAM SpoVT AbrB
P12B_RS15985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P12B_RS15990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
P12B_RS15995	COG3850	Histidine kinase
P12B_RS15995	COG4999	Histidine kinase
P12B_RS15995	COG3437	response regulator, receiver
P12B_RS15995	COG2205	protein histidine kinase activity
P12B_RS16000	COG4948	Mandelate Racemase Muconate Lactonizing
P12B_RS16005	COG4948	Mandelate Racemase Muconate Lactonizing
P12B_RS16010	COG2271	Major facilitator Superfamily
P12B_RS16015	COG0716	FMN binding
P12B_RS16020	COG0564	pseudouridine synthase activity
P12B_RS16025	COG3098	single-species biofilm formation
P12B_RS16045	COG1611	Belongs to the LOG family
P12B_RS16050	COG0814	amino acid
P12B_RS16055	COG1760	l-serine dehydratase
P12B_RS16065	COG1454	alcohol dehydrogenase
P12B_RS16070	COG0235	Class ii aldolase
P12B_RS16085	COG1070	Carbohydrate kinase
P12B_RS16095	COG1349	DNA-binding transcription factor activity
P12B_RS16105	COG2363	Small membrane protein
P12B_RS16110	COG0583	DNA-binding transcription factor activity
P12B_RS16120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P12B_RS16125	COG2166	iron-sulfur cluster assembly
P12B_RS16130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
P12B_RS16135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
P12B_RS16155	COG0860	N-Acetylmuramoyl-L-alanine amidase
P12B_RS16160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
P12B_RS16160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P12B_RS16165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P12B_RS16170	COG1074	ATP-dependent DNA helicase activity
P12B_RS16175	COG1025	Belongs to the peptidase M16 family
P12B_RS16180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
P12B_RS16185	COG4967	type IV pilus modification protein PilV
P12B_RS16195	COG4795	General secretion pathway protein
P12B_RS16200	COG2165	general secretion pathway protein
P12B_RS16215	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
P12B_RS16240	COG0861	Integral membrane protein TerC family
P12B_RS16250	COG0667	Aldo Keto reductase
P12B_RS16265	COG1609	Transcriptional regulator
P12B_RS16275	COG0583	DNA-binding transcription factor activity
P12B_RS16280	COG1794	racemase activity, acting on amino acids and derivatives
P12B_RS16285	COG2814	Major facilitator Superfamily
P12B_RS16290	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS16300	COG0183	Belongs to the thiolase family
P12B_RS16305	COG0814	amino acid
P12B_RS16310	COG2771	luxR family
P12B_RS16315	COG3710	Transcriptional regulator
P12B_RS16335	COG0457	Tetratricopeptide repeat
P12B_RS16340	COG3710	Transcriptional regulator
P12B_RS16340	COG0457	Tetratricopeptide repeat
P12B_RS16350	COG3710	Transcriptional regulator
P12B_RS16350	COG0457	Tetratricopeptide repeat
P12B_RS16365	COG2197	response regulator
P12B_RS16370	COG2197	response regulator
P12B_RS16450	COG3387	PFAM Glycoside hydrolase 15-related
P12B_RS16455	COG3387	PFAM Glycoside hydrolase 15-related
P12B_RS16465	COG4942	peptidase
P12B_RS16470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
P12B_RS16475	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
P12B_RS16480	COG2080	2 iron, 2 sulfur cluster binding
P12B_RS16485	COG3829	transcription factor binding
P12B_RS16495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P12B_RS16500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
P12B_RS16515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
P12B_RS16515	COG3608	succinylglutamate desuccinylase aspartoacylase
P12B_RS16520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P12B_RS16525	COG2068	MobA-Related Protein
P12B_RS16530	COG0493	'glutamate synthase
P12B_RS16530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS16535	COG0402	S-adenosylhomocysteine deaminase activity
P12B_RS16540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
P12B_RS16545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
P12B_RS16545	COG2080	2 iron, 2 sulfur cluster binding
P12B_RS16550	COG2233	PERMEase
P12B_RS16555	COG0402	S-adenosylhomocysteine deaminase activity
P12B_RS16560	COG2252	PERMEase
P12B_RS16565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS16570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS16570	COG0493	'glutamate synthase
P12B_RS16595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P12B_RS16605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P12B_RS16610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P12B_RS16615	COG4974	Belongs to the 'phage' integrase family
P12B_RS16620	COG0716	FMN binding
P12B_RS16630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
P12B_RS16640	COG1272	protein, Hemolysin III
P12B_RS16650	COG2723	6-phospho-beta-galactosidase activity
P12B_RS16655	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS16680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P12B_RS16685	COG0006	proline dipeptidase activity
P12B_RS16700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
P12B_RS16710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P12B_RS16730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
P12B_RS16730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
P12B_RS16735	COG1703	isobutyryl-CoA mutase activity
P12B_RS16740	COG1024	Enoyl-CoA hydratase
P12B_RS16745	COG0427	acetyl-CoA hydrolase
P12B_RS16750	COG0583	DNA-binding transcription factor activity
P12B_RS16755	COG2968	Membrane
P12B_RS16760	COG1279	arginine transmembrane transporter activity
P12B_RS16765	COG0668	transmembrane transport
P12B_RS16770	COG0191	fructose-bisphosphate aldolase activity
P12B_RS16785	COG1072	(Pantothenic acid kinase))
P12B_RS16790	COG3722	fumarate hydratase activity
P12B_RS16795	COG1494	fructose-1,6-bisphosphatase
P12B_RS16800	COG1063	alcohol dehydrogenase
P12B_RS16805	COG2213	PTS system mannitol-specific
P12B_RS16810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS16815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P12B_RS16820	COG0501	Belongs to the peptidase M48B family
P12B_RS16830	COG1166	arginine decarboxylase activity
P12B_RS16855	COG2814	Major facilitator Superfamily
P12B_RS16865	COG2356	endonuclease I
P12B_RS16870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P12B_RS16875	COG0189	ligase activity
P12B_RS16890	COG2805	Type II/IV secretion system protein
P12B_RS16900	COG0762	integral membrane protein
P12B_RS16910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
P12B_RS16915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P12B_RS16925	COG0252	asparaginase activity
P12B_RS16940	COG3171	Protein conserved in bacteria
P12B_RS16950	COG1194	a g-specific adenine glycosylase
P12B_RS16965	COG2211	Major facilitator Superfamily
P12B_RS16975	COG1811	Na channel or pump
P12B_RS16985	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
P12B_RS17015	COG2165	general secretion pathway protein
P12B_RS17020	COG1459	type II secretion system
P12B_RS17025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P12B_RS17035	COG3031	protein transport across the cell outer membrane
P12B_RS17045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P12B_RS17050	COG3064	Membrane
P12B_RS17060	COG1620	l-lactate permease
P12B_RS17070	COG3193	protein, possibly involved in utilization of glycolate and propanediol
P12B_RS17075	COG0247	lactate metabolic process
P12B_RS17080	COG0277	FAD linked oxidase domain protein
P12B_RS17085	COG0277	FAD linked oxidase domain protein
P12B_RS17090	COG2186	Transcriptional regulator
P12B_RS17110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P12B_RS17115	COG0156	8-amino-7-oxononanoate synthase activity
P12B_RS17125	COG0795	lipopolysaccharide-transporting ATPase activity
P12B_RS17140	COG2244	polysaccharide biosynthetic process
P12B_RS17145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P12B_RS17150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P12B_RS17155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P12B_RS17160	COG0306	phosphate transporter
P12B_RS17165	COG0754	glutathionylspermidine amidase activity
P12B_RS17170	COG0625	glutathione transferase activity
P12B_RS17175	COG0298	carbon dioxide binding
P12B_RS17185	COG1773	rubredoxin
P12B_RS17190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
P12B_RS17195	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
P12B_RS17200	COG5557	Pfam Polysulphide reductase, NrfD
P12B_RS17205	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS17210	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
P12B_RS17230	COG0667	Aldo Keto reductase
P12B_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS17245	COG0848	biopolymer transport protein
P12B_RS17250	COG0811	peptide transport
P12B_RS17265	COG0586	Pfam SNARE associated Golgi protein
P12B_RS17270	COG2207	Transcriptional regulator
P12B_RS17280	COG1979	alcohol dehydrogenase
P12B_RS17285	COG0656	L-ascorbic acid biosynthetic process
P12B_RS17295	COG4238	major outer membrane lipoprotein
P12B_RS17300	COG1032	radical SAM domain protein
P12B_RS17305	COG2132	Multicopper oxidase
P12B_RS17310	COG0204	Acyl-transferase
P12B_RS17315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P12B_RS17320	COG4166	transmembrane transport
P12B_RS17325	COG2944	sequence-specific DNA binding
P12B_RS17335	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
P12B_RS17340	COG3111	PFAM Bacterial OB fold (BOF) protein
P12B_RS17345	COG0745	RESPONSE REGULATOR receiver
P12B_RS17350	COG0642	Histidine kinase
P12B_RS17360	COG2249	NAD(P)H dehydrogenase (quinone) activity
P12B_RS17365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
P12B_RS17370	COG0187	DNA topoisomerase II activity
P12B_RS17375	COG3150	esterase
P12B_RS17380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
P12B_RS17385	COG3151	Protein conserved in bacteria
P12B_RS17390	COG0494	nUDIX hydrolase
P12B_RS17395	COG1538	Outer membrane efflux protein
P12B_RS17410	COG0754	glutathionylspermidine amidase activity
P12B_RS17415	COG3384	dioxygenase
P12B_RS17435	COG2960	long-chain fatty acid transporting porin activity
P12B_RS17440	COG3539	Fimbrial protein
P12B_RS17445	COG3188	usher protein
P12B_RS17450	COG3121	Chaperone
P12B_RS17455	COG3539	Fimbrial protein
P12B_RS17465	COG1585	Membrane protein implicated in regulation of membrane protease activity
P12B_RS17470	COG2268	Band 7 protein
P12B_RS17495	COG3025	triphosphatase activity
P12B_RS17505	COG4991	sh3 domain protein
P12B_RS17520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P12B_RS17530	COG0583	DNA-binding transcription factor activity
P12B_RS17535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
P12B_RS17540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
P12B_RS17545	COG0471	metal ion transport
P12B_RS17555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P12B_RS17560	COG0358	DNA primase activity
P12B_RS17565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P12B_RS17605	COG3468	outer membrane autotransporter barrel domain protein
P12B_RS17610	COG2378	regulation of single-species biofilm formation
P12B_RS17620	COG3596	GTP binding
P12B_RS17625	COG0583	DNA-binding transcription factor activity
P12B_RS17675	COG4983	Phage plasmid primase, P4 family domain protein
P12B_RS17700	COG2375	cellular response to nickel ion
P12B_RS17705	COG1695	Transcriptional regulator
P12B_RS17710	COG0840	transmembrane signaling receptor activity
P12B_RS17720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P12B_RS17725	COG1609	Transcriptional regulator
P12B_RS17730	COG3250	beta-galactosidase activity
P12B_RS17735	COG2731	YhcH YjgK YiaL family protein
P12B_RS17740	COG0531	amino acid
P12B_RS17750	COG3408	Glycogen debranching enzyme
P12B_RS17750	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
P12B_RS17755	COG1902	pentaerythritol trinitrate reductase activity
P12B_RS17755	COG0446	pyridine nucleotide-disulphide oxidoreductase
P12B_RS17760	COG5499	transcription regulator containing HTH domain
P12B_RS17765	COG4680	protein conserved in bacteria
P12B_RS17780	COG1451	nucleotide metabolic process
P12B_RS17785	COG2949	membrane
P12B_RS17790	COG0673	inositol 2-dehydrogenase activity
P12B_RS17795	COG0673	inositol 2-dehydrogenase activity
P12B_RS17800	COG0861	Integral membrane protein TerC family
P12B_RS17805	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
P12B_RS17815	COG2721	sulfolactate sulfo-lyase activity
P12B_RS17825	COG2271	Major facilitator Superfamily
P12B_RS17850	COG2186	Transcriptional regulator
P12B_RS17855	COG0586	Pfam SNARE associated Golgi protein
P12B_RS17865	COG1422	Protein of unknown function (DUF1090)
P12B_RS17870	COG4575	ribosome binding
P12B_RS17875	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
P12B_RS17885	COG2259	Doxx family
P12B_RS17890	COG0435	Glutathione S-transferase
P12B_RS17895	COG3152	Membrane
P12B_RS17900	COG3152	Membrane
P12B_RS17905	COG0583	DNA-binding transcription factor activity
P12B_RS17910	COG1741	Belongs to the pirin family
P12B_RS17925	COG0814	amino acid
P12B_RS17930	COG1760	l-serine dehydratase
P12B_RS17935	COG0251	oxidation-reduction process
P12B_RS17940	COG1882	Formate acetyltransferase
P12B_RS17945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
P12B_RS17955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P12B_RS17960	COG0583	DNA-binding transcription factor activity
P12B_RS17980	COG1929	Belongs to the glycerate kinase type-1 family
P12B_RS17985	COG2084	Dehydrogenase
P12B_RS17995	COG2271	Major facilitator Superfamily
P12B_RS18010	COG2002	toxin-antitoxin pair type II binding
P12B_RS18020	COG1349	DNA-binding transcription factor activity
P12B_RS18030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS18045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS18050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
P12B_RS18055	COG2222	sugar isomerase
P12B_RS18065	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS18070	COG3715	PTS system
P12B_RS18075	COG3716	PTS system mannose fructose sorbose family IID component
P12B_RS18080	COG0363	glucosamine-6-phosphate deaminase activity
P12B_RS18085	COG3539	Fimbrial protein
P12B_RS18100	COG3539	Fimbrial protein
P12B_RS18105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
P12B_RS18110	COG3107	peptidoglycan biosynthetic process
P12B_RS18125	COG2823	Periplasmic or secreted lipoprotein
P12B_RS18130	COG0701	Predicted permease
P12B_RS18135	COG0702	epimerase
P12B_RS18140	COG0693	protein deglycase activity
P12B_RS18155	COG3153	acetyltransferase
P12B_RS18160	COG3154	lipid carrier protein
P12B_RS18165	COG0826	peptidase U32
P12B_RS18170	COG0826	peptidase U32
P12B_RS18175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
P12B_RS18180	COG0814	amino acid
P12B_RS18190	COG0513	Belongs to the DEAD box helicase family
P12B_RS18225	COG0195	Participates in both transcription termination and antitermination
P12B_RS18245	COG2194	sulfuric ester hydrolase activity
P12B_RS18265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P12B_RS18270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P12B_RS18280	COG1534	Rna-binding protein
P12B_RS18285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P12B_RS18290	COG2027	D-alanyl-D-alanine carboxypeptidase
P12B_RS18325	COG0142	geranyltranstransferase activity
P12B_RS18330	COG3423	Transcriptional regulator
P12B_RS18340	COG5007	Belongs to the BolA IbaG family
P12B_RS18345	COG3113	response to antibiotic
P12B_RS18350	COG2854	intermembrane phospholipid transfer
P12B_RS18355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
P12B_RS18360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P12B_RS18365	COG1127	ABC transporter
P12B_RS18375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
P12B_RS18375	COG0517	IMP dehydrogenase activity
P12B_RS18380	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
P12B_RS18385	COG3117	lipopolysaccharide transmembrane transporter activity
P12B_RS18390	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
P12B_RS18395	COG1137	ATPase activity
P12B_RS18400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
P12B_RS18405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
P12B_RS18420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS18425	COG0515	serine threonine protein kinase
P12B_RS18435	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
P12B_RS18445	COG1242	4 iron, 4 sulfur cluster binding
P12B_RS18450	COG0067	glutamate synthase
P12B_RS18450	COG0070	glutamate synthase
P12B_RS18450	COG0069	glutamate synthase activity
P12B_RS18455	COG0493	'glutamate synthase
P12B_RS18460	COG4804	nuclease activity
P12B_RS18470	COG2731	YhcH YjgK YiaL family protein
P12B_RS18505	COG2969	positive regulation of protein catabolic process
P12B_RS18510	COG0625	glutathione transferase activity
P12B_RS18525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
P12B_RS18530	COG3105	Protein conserved in bacteria
P12B_RS18535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P12B_RS18540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P12B_RS18560	COG2732	(Barnase) inhibitor
P12B_RS18580	COG0583	DNA-binding transcription factor activity
P12B_RS18585	COG0312	modulator of DNA gyrase
P12B_RS18590	COG3164	Protein of unknown function
P12B_RS18595	COG1530	ribonuclease E activity
P12B_RS18600	COG0424	maF-like protein
P12B_RS18605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
P12B_RS18610	COG1792	Involved in formation and maintenance of cell shape
P12B_RS18615	COG1077	Cell shape determining protein MreB Mrl
P12B_RS18625	COG2199	diguanylate cyclase activity
P12B_RS18625	COG2200	EAL domain
P12B_RS18630	COG0604	alcohol dehydrogenase
P12B_RS18650	COG0511	ligase activity, forming carbon-carbon bonds
P12B_RS18655	COG0439	Biotin carboxylase
P12B_RS18660	COG3924	membrane
P12B_RS18665	COG4145	pantothenate transmembrane transporter activity
P12B_RS18675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P12B_RS18685	COG2189	Belongs to the N(4) N(6)-methyltransferase family
P12B_RS18695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
P12B_RS18700	COG4597	amino acid ABC transporter
P12B_RS18705	COG0765	amino acid transport
P12B_RS18710	COG1126	abc transporter atp-binding protein
P12B_RS18770	COG0551	DNA topoisomerase type I activity
P12B_RS18800	COG0569	domain protein
P12B_RS18810	COG3036	rescue of stalled ribosome
P12B_RS18815	COG0789	Transcriptional regulator
P12B_RS18855	COG0201	protein transport
P12B_RS18945	COG0089	rRNA binding
P12B_RS18970	COG3267	Type II secretory pathway component ExeA
P12B_RS18970	COG3409	Peptidoglycan-binding domain 1 protein
P12B_RS18975	COG3031	protein transport across the cell outer membrane
P12B_RS18980	COG2801	Transposase and inactivated derivatives
P12B_RS18990	COG1450	Type ii and iii secretion system protein
P12B_RS18995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P12B_RS19000	COG1459	type II secretion system
P12B_RS19005	COG2165	general secretion pathway protein
P12B_RS19010	COG2165	general secretion pathway protein
P12B_RS19020	COG4795	General secretion pathway protein
P12B_RS19025	COG3156	type II secretion system protein K
P12B_RS19030	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
P12B_RS19035	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
P12B_RS19045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P12B_RS19050	COG2193	ferroxidase activity
P12B_RS19055	COG2906	2 iron, 2 sulfur cluster binding
P12B_RS19060	COG3979	chitinase
P12B_RS19100	COG2964	Protein conserved in bacteria
P12B_RS19105	COG0545	Peptidyl-prolyl cis-trans isomerase
P12B_RS19115	COG1047	Peptidyl-prolyl cis-trans
P12B_RS19120	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
P12B_RS19135	COG0488	(ABC) transporter
P12B_RS19140	COG0429	hydrolase of the alpha beta-hydrolase fold
P12B_RS19150	COG3954	Phosphoribulokinase
P12B_RS19155	COG1765	OsmC-like protein
P12B_RS19165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P12B_RS19170	COG1289	transmembrane transporter activity
P12B_RS19175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P12B_RS19180	COG0512	Glutamine amidotransferase of anthranilate synthase
P12B_RS19185	COG2184	nucleotidyltransferase activity
P12B_RS19195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P12B_RS19205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P12B_RS19210	COG2146	nitrite reductase [NAD(P)H] activity
P12B_RS19215	COG2116	formate transmembrane transporter activity
P12B_RS19230	COG0531	amino acid
P12B_RS19235	COG2222	sugar isomerase
P12B_RS19240	COG1082	Xylose isomerase domain protein TIM barrel
P12B_RS19250	COG2188	Transcriptional regulator
P12B_RS19255	COG0626	cystathionine gamma-synthase activity
P12B_RS19270	COG1735	metal-dependent hydrolase with the TIM-barrel fold
P12B_RS19275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
P12B_RS19280	COG3457	Alanine racemase
P12B_RS19290	COG2188	Transcriptional regulator
P12B_RS19295	COG0180	Tryptophanyl-tRNA synthetase
P12B_RS19300	COG0546	phosphoglycolate phosphatase activity
P12B_RS19305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
P12B_RS19310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
P12B_RS19315	COG3266	domain, Protein
P12B_RS19330	COG4796	Type ii and iii secretion system protein
P12B_RS19345	COG3166	PFAM Fimbrial assembly family protein
P12B_RS19350	COG4972	Pilus assembly protein
P12B_RS19355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
P12B_RS19360	COG0494	nUDIX hydrolase
P12B_RS19370	COG1011	Hydrolase
P12B_RS19375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
P12B_RS19385	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
P12B_RS19410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P12B_RS19420	COG1918	ferrous iron import across plasma membrane
P12B_RS19425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
P12B_RS19435	COG5464	transposase or invertase
P12B_RS19455	COG2610	gluconate transmembrane transporter activity
P12B_RS19460	COG1640	4-alpha-glucanotransferase
P12B_RS19465	COG0058	SHG alpha-glucan phosphorylase activity
P12B_RS19480	COG1690	Belongs to the RtcB family
P12B_RS19485	COG4650	regulator
P12B_RS19505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
P12B_RS19520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P12B_RS19525	COG0058	SHG alpha-glucan phosphorylase activity
P12B_RS19550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P12B_RS19555	COG2095	MarC family integral membrane protein
P12B_RS19560	COG2610	gluconate transmembrane transporter activity
P12B_RS19565	COG3265	gluconokinase activity
P12B_RS19570	COG1609	Transcriptional regulator
P12B_RS19575	COG1741	Belongs to the pirin family
P12B_RS19580	COG0673	inositol 2-dehydrogenase activity
P12B_RS19585	COG1247	-acetyltransferase
P12B_RS19590	COG3157	Type VI secretion system effector, Hcp
P12B_RS19605	COG0405	Gamma-glutamyltransferase
P12B_RS19615	COG0584	glycerophosphoryl diester phosphodiesterase
P12B_RS19620	COG3842	ATPase activity
P12B_RS19630	COG1175	transmembrane transport
P12B_RS19635	COG1653	transport
P12B_RS19645	COG0410	ABC transporter
P12B_RS19650	COG0411	ABC transporter
P12B_RS19655	COG4177	L-phenylalanine transmembrane transporter activity
P12B_RS19660	COG0559	Belongs to the binding-protein-dependent transport system permease family
P12B_RS19665	COG0683	leucine binding
P12B_RS19670	COG0456	acetyltransferase
P12B_RS19680	COG0683	leucine binding
P12B_RS19685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P12B_RS19690	COG2177	Part of the ABC transporter FtsEX involved in
P12B_RS19695	COG2884	Cell division ATP-binding protein ftsE
P12B_RS19700	COG0552	protein localization to endoplasmic reticulum
P12B_RS19705	COG0742	ribosomal rna small subunit methyltransferase
P12B_RS19710	COG3776	membrane
P12B_RS19720	COG3714	YhhN family
P12B_RS19735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
P12B_RS19755	COG2091	lysine biosynthetic process via aminoadipic acid
P12B_RS19760	COG0747	negative chemotaxis
P12B_RS19765	COG0601	transmembrane transport
P12B_RS19770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P12B_RS19775	COG0444	Belongs to the ABC transporter superfamily
P12B_RS19790	COG3209	COG3209 Rhs family protein
P12B_RS19805	COG5433	transposase activity
P12B_RS19815	COG0842	Transport permease protein
P12B_RS19820	COG0842	Transport permease protein
P12B_RS19820	COG1129	ABC transporter
P12B_RS19825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS19845	COG3436	PFAM IS66 Orf2 family protein
P12B_RS19860	COG2205	protein histidine kinase activity
P12B_RS19870	COG1276	copper resistance
P12B_RS19875	COG2372	response to copper ion
P12B_RS19880	COG3667	copper resistance
P12B_RS19885	COG2132	Multicopper oxidase
P12B_RS19900	COG0739	heme binding
P12B_RS19920	COG3436	PFAM IS66 Orf2 family protein
P12B_RS19950	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS20015	COG2081	HI0933 family
P12B_RS20020	COG0306	phosphate transporter
P12B_RS20030	COG0589	response to stress
P12B_RS20035	COG3104	oligopeptide transport
P12B_RS20045	COG0339	signal peptide processing
P12B_RS20050	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
P12B_RS20055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P12B_RS20070	COG0640	Transcriptional regulator
P12B_RS20075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
P12B_RS20080	COG1393	Belongs to the ArsC family
P12B_RS20090	COG3065	identical protein binding
P12B_RS20095	COG2197	response regulator
P12B_RS20100	COG1285	pathogenesis
P12B_RS20115	COG3247	response to pH
P12B_RS20120	COG2771	luxR family
P12B_RS20130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P12B_RS20135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P12B_RS20140	COG2207	Transcriptional regulator
P12B_RS20145	COG2207	Transcriptional regulator
P12B_RS20150	COG0076	glutamate decarboxylase activity
P12B_RS20155	COG1858	cytochrome C peroxidase
P12B_RS20165	COG2197	response regulator
P12B_RS20170	COG0583	DNA-binding transcription factor activity
P12B_RS20175	COG1295	ribonuclease BN
P12B_RS20180	COG0477	Major facilitator Superfamily
P12B_RS20185	COG2982	Protein involved in outer membrane biogenesis
P12B_RS20190	COG2200	EAL domain
P12B_RS20200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS20205	COG0612	Peptidase, M16
P12B_RS20215	COG2199	diguanylate cyclase activity
P12B_RS20215	COG2200	EAL domain
P12B_RS20220	COG0457	Tetratricopeptide repeat
P12B_RS20220	COG3118	belongs to the thioredoxin family
P12B_RS20225	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
P12B_RS20230	COG1215	transferase activity, transferring glycosyl groups
P12B_RS20235	COG1215	transferase activity, transferring glycosyl groups
P12B_RS20260	COG2194	sulfuric ester hydrolase activity
P12B_RS20280	COG0814	amino acid
P12B_RS20285	COG4608	Belongs to the ABC transporter superfamily
P12B_RS20290	COG0444	Belongs to the ABC transporter superfamily
P12B_RS20295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P12B_RS20300	COG0601	transmembrane transport
P12B_RS20310	COG0747	negative chemotaxis
P12B_RS20325	COG2194	sulfuric ester hydrolase activity
P12B_RS20330	COG2223	nitrite transmembrane transporter activity
P12B_RS20335	COG5571	outer membrane autotransporter
P12B_RS20340	COG2818	Glycosylase
P12B_RS20345	COG0456	acetyltransferase
P12B_RS20350	COG0243	molybdopterin cofactor binding
P12B_RS20355	COG2885	chlorophyll binding
P12B_RS20370	COG2944	sequence-specific DNA binding
P12B_RS20375	COG1278	Cold shock
P12B_RS20385	COG2963	transposase activity
P12B_RS20390	COG2801	Transposase and inactivated derivatives
P12B_RS20410	COG3274	enterobacterial common antigen metabolic process
P12B_RS20415	COG4682	membrane
P12B_RS20420	COG4682	membrane
P12B_RS20425	COG1070	Carbohydrate kinase
P12B_RS20435	COG4213	ABC transporter substrate-binding protein
P12B_RS20440	COG1129	ABC transporter
P12B_RS20445	COG4214	carbohydrate transport
P12B_RS20450	COG1609	Transcriptional regulator
P12B_RS20450	COG2207	Transcriptional regulator
P12B_RS20455	COG2992	FlgJ-related protein
P12B_RS20460	COG0366	Alpha amylase catalytic
P12B_RS20465	COG3977	Valine--pyruvate aminotransferase
P12B_RS20475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
P12B_RS20480	COG1414	Transcriptional regulator
P12B_RS20490	COG2731	YhcH YjgK YiaL family protein
P12B_RS20495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
P12B_RS20500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
P12B_RS20505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P12B_RS20510	COG1070	Carbohydrate kinase
P12B_RS20515	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
P12B_RS20520	COG3623	hexulose-6-phosphate isomerase
P12B_RS20525	COG0235	Class ii aldolase
P12B_RS20530	COG3713	MltA-interacting MipA family protein
P12B_RS20535	COG0583	DNA-binding transcription factor activity
P12B_RS20540	COG1566	PFAM secretion protein HlyD family protein
P12B_RS20555	COG1012	belongs to the aldehyde dehydrogenase family
P12B_RS20560	COG1454	alcohol dehydrogenase
P12B_RS20565	COG3276	selenocysteine insertion sequence binding
P12B_RS20575	COG0625	glutathione transferase activity
P12B_RS20580	COG3209	COG3209 Rhs family protein
P12B_RS20585	COG3209	COG3209 Rhs family protein
P12B_RS20590	COG1413	lyase activity
P12B_RS20595	COG3209	COG3209 Rhs family protein
P12B_RS20610	COG1566	PFAM secretion protein HlyD family protein
P12B_RS20620	COG2213	PTS system mannitol-specific
P12B_RS20620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS20630	COG3722	fumarate hydratase activity
P12B_RS20650	COG5295	Hep Hag repeat protein
P12B_RS20655	COG1620	l-lactate permease
P12B_RS20660	COG2186	Transcriptional regulator
P12B_RS20670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
P12B_RS20675	COG1045	serine acetyltransferase
P12B_RS20690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P12B_RS20695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P12B_RS20705	COG4942	peptidase
P12B_RS20710	COG2861	carbohydrate metabolic process
P12B_RS20715	COG1216	Glycosyl transferase, family 2
P12B_RS20725	COG0156	8-amino-7-oxononanoate synthase activity
P12B_RS20735	COG0859	PFAM glycosyl transferase family 9
P12B_RS20740	COG0859	PFAM glycosyl transferase family 9
P12B_RS20745	COG3307	-O-antigen
P12B_RS20750	COG1216	Glycosyl transferase, family 2
P12B_RS20755	COG1442	glycosyl transferase family 8
P12B_RS20775	COG0515	serine threonine protein kinase
P12B_RS20780	COG0438	transferase activity, transferring glycosyl groups
P12B_RS20785	COG0859	PFAM glycosyl transferase family 9
P12B_RS20790	COG1519	Transferase
P12B_RS20805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P12B_RS20820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P12B_RS20850	COG3645	SOS response
P12B_RS20855	COG2860	membrane
P12B_RS20880	COG0194	GDP metabolic process
P12B_RS20890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P12B_RS20895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P12B_RS20900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P12B_RS20905	COG0786	glutamate:sodium symporter activity
P12B_RS20910	COG2233	PERMEase
P12B_RS20915	COG2982	Protein involved in outer membrane biogenesis
P12B_RS20920	COG1501	Belongs to the glycosyl hydrolase 31 family
P12B_RS20925	COG2211	Major facilitator Superfamily
P12B_RS20935	COG0582	viral genome integration into host DNA
P12B_RS20950	COG2801	Transposase and inactivated derivatives
P12B_RS20955	COG3344	reverse transcriptase
P12B_RS20965	COG2963	transposase activity
P12B_RS20970	COG2963	transposase activity
P12B_RS20985	COG2814	Major facilitator Superfamily
P12B_RS20990	COG0697	spore germination
P12B_RS20995	COG1464	Belongs to the NlpA lipoprotein family
P12B_RS21020	COG2252	PERMEase
P12B_RS21030	COG2271	Major facilitator Superfamily
P12B_RS21035	COG2271	Major facilitator Superfamily
P12B_RS21040	COG3851	Histidine kinase
P12B_RS21045	COG2197	response regulator
P12B_RS21050	COG0440	acetolactate synthase activity
P12B_RS21055	COG0028	Belongs to the TPP enzyme family
P12B_RS21080	COG2814	Major facilitator Superfamily
P12B_RS21085	COG0641	radical SAM
P12B_RS21095	COG2149	membrane
P12B_RS21115	COG2188	Transcriptional regulator
P12B_RS21135	COG5645	(Lipo)protein
P12B_RS21140	COG0823	Involved in the tonB-independent uptake of proteins
P12B_RS21150	COG2271	Major facilitator Superfamily
P12B_RS21160	COG0800	Aldolase
P12B_RS21165	COG3734	2-keto-3-deoxy-galactonokinase
P12B_RS21170	COG2186	Transcriptional regulator
P12B_RS21180	COG0561	phosphatase activity
P12B_RS21185	COG3753	Protein conserved in bacteria
P12B_RS21195	COG0187	DNA topoisomerase II activity
P12B_RS21205	COG0592	DNA-directed DNA polymerase activity
P12B_RS21255	COG0814	amino acid
P12B_RS21275	COG0431	NADPH-dependent FMN reductase
P12B_RS21280	COG2252	PERMEase
P12B_RS21285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
P12B_RS21295	COG3196	Protein conserved in bacteria
P12B_RS21300	COG0363	glucosamine-6-phosphate deaminase activity
P12B_RS21315	COG2723	6-phospho-beta-galactosidase activity
P12B_RS21320	COG2190	(PTS) system
P12B_RS21320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS21320	COG1263	PTS System
P12B_RS21330	COG3711	transcriptional antiterminator
P12B_RS21340	COG0704	Plays a role in the regulation of phosphate uptake
P12B_RS21345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
P12B_RS21350	COG0581	inorganic phosphate transmembrane transporter activity
P12B_RS21355	COG0573	inorganic phosphate transmembrane transporter activity
P12B_RS21360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P12B_RS21415	COG3312	ion transport
P12B_RS21430	COG0716	FMN binding
P12B_RS21435	COG1522	sequence-specific DNA binding
P12B_RS21465	COG1129	ABC transporter
P12B_RS21470	COG1172	Belongs to the binding-protein-dependent transport system permease family
P12B_RS21475	COG1879	ABC-type sugar transport system periplasmic component
P12B_RS21480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS21485	COG1609	Transcriptional regulator
P12B_RS21490	COG0477	Major facilitator Superfamily
P12B_RS21495	COG2186	Transcriptional regulator
P12B_RS21535	COG3085	chromosome segregation
P12B_RS21540	COG0606	chelatase, subunit chli
P12B_RS21555	COG3978	acetolactate synthase activity
P12B_RS21560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P12B_RS21570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P12B_RS21575	COG0583	DNA-binding transcription factor activity
P12B_RS21585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P12B_RS21595	COG0210	DNA helicase
P12B_RS21610	COG3118	belongs to the thioredoxin family
P12B_RS21620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
P12B_RS21630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P12B_RS21635	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
P12B_RS21640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
P12B_RS21645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
P12B_RS21650	COG1088	dTDP-glucose 4,6-dehydratase activity
P12B_RS21660	COG0456	acetyltransferase
P12B_RS21665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
P12B_RS21690	COG1113	amino acid transport
P12B_RS21715	COG0641	radical SAM
P12B_RS21720	COG3119	arylsulfatase activity
P12B_RS21725	COG3071	HemY protein
P12B_RS21730	COG2959	enzyme of heme biosynthesis
P12B_RS21735	COG1587	Uroporphyrinogen-III synthase
P12B_RS21745	COG3072	Adenylate cyclase
P12B_RS21755	COG5567	small periplasmic lipoprotein
P12B_RS21765	COG3159	Protein conserved in bacteria
P12B_RS21775	COG1011	Hydrolase
P12B_RS21780	COG0210	DNA helicase
P12B_RS21785	COG3698	Phosphodiester glycosidase
P12B_RS21795	COG0598	Magnesium transport protein CorA
P12B_RS21810	COG2962	Rard protein
P12B_RS21815	COG2050	protein possibly involved in aromatic compounds catabolism
P12B_RS21820	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
P12B_RS21825	COG0514	ATP-dependent DNA helicase (RecQ)
P12B_RS21830	COG1280	lysine exporter protein (LysE YggA)
P12B_RS21835	COG1280	lysine exporter protein (LysE YggA)
P12B_RS21840	COG2267	carboxylic ester hydrolase activity
P12B_RS21845	COG0561	phosphatase activity
P12B_RS21850	COG0697	spore germination
P12B_RS21855	COG0583	DNA-binding transcription factor activity
P12B_RS21865	COG0412	Dienelactone hydrolase
P12B_RS21870	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
P12B_RS21875	COG1322	Protein conserved in bacteria
P12B_RS21885	COG3165	ubiquinone biosynthetic process from chorismate
P12B_RS21895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P12B_RS21900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P12B_RS21905	COG0805	protein transport
P12B_RS21910	COG0084	hydrolase, TatD family'
P12B_RS21920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
P12B_RS21925	COG0543	2 iron, 2 sulfur cluster binding
P12B_RS21945	COG1739	Uncharacterized protein family UPF0029
P12B_RS21950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P12B_RS21955	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
P12B_RS21985	COG1763	Mo-molybdopterin cofactor biosynthetic process
P12B_RS21990	COG0746	molybdenum cofactor guanylyltransferase activity
P12B_RS21995	COG3084	Protein conserved in bacteria
P12B_RS22000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
P12B_RS22005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P12B_RS22015	COG5339	Protein conserved in bacteria
P12B_RS22030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P12B_RS22030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P12B_RS22040	COG3078	GTPase activator activity
P12B_RS22045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P12B_RS22055	COG2204	response regulator
P12B_RS22065	COG0174	glutamine synthetase
P12B_RS22075	COG1217	gtp-binding protein TYPA
P12B_RS22080	COG2188	Transcriptional regulator
P12B_RS22085	COG1082	Xylose isomerase domain protein TIM barrel
P12B_RS22090	COG2271	Major facilitator Superfamily
P12B_RS22100	COG2271	Major facilitator Superfamily
P12B_RS22105	COG1349	DNA-binding transcription factor activity
P12B_RS22110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P12B_RS22115	COG2084	Dehydrogenase
P12B_RS22120	COG3684	Belongs to the aldolase LacD family
P12B_RS22125	COG1063	alcohol dehydrogenase
P12B_RS22135	COG0477	Major facilitator Superfamily
P12B_RS22145	COG1011	Hydrolase
P12B_RS22160	COG0456	acetyltransferase
P12B_RS22165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
P12B_RS22170	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
P12B_RS22185	COG2864	formate dehydrogenase
P12B_RS22190	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS22195	COG0243	molybdopterin cofactor binding
P12B_RS22195	COG3383	formate dehydrogenase (NAD+) activity
P12B_RS22200	COG0243	molybdopterin cofactor binding
P12B_RS22200	COG3383	formate dehydrogenase (NAD+) activity
P12B_RS22215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS22215	COG3711	transcriptional antiterminator
P12B_RS22220	COG1363	Peptidase, m42
P12B_RS22225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS22225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS22230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS22275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
P12B_RS22290	COG2258	MOSC domain
P12B_RS22295	COG2205	protein histidine kinase activity
P12B_RS22300	COG0745	RESPONSE REGULATOR receiver
P12B_RS22305	COG3678	ATP-independent chaperone mediated protein folding
P12B_RS22320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
P12B_RS22340	COG3152	Membrane
P12B_RS22345	COG3691	Protein conserved in bacteria
P12B_RS22350	COG0589	response to stress
P12B_RS22355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P12B_RS22360	COG1494	fructose-1,6-bisphosphatase
P12B_RS22370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
P12B_RS22385	COG1575	Belongs to the MenA family. Type 1 subfamily
P12B_RS22400	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
P12B_RS22405	COG1609	Transcriptional regulator
P12B_RS22410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P12B_RS22445	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
P12B_RS22455	COG0626	cystathionine gamma-synthase activity
P12B_RS22460	COG0527	aspartate kinase activity
P12B_RS22460	COG0460	homoserine dehydrogenase
P12B_RS22470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
P12B_RS22480	COG0697	spore germination
P12B_RS22485	COG3738	Protein conserved in bacteria
P12B_RS22495	COG0371	Dehydrogenase
P12B_RS22500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P12B_RS22505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P12B_RS22505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS22505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
P12B_RS22510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS22515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS22520	COG1882	Formate acetyltransferase
P12B_RS22525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
P12B_RS22530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
P12B_RS22535	COG2207	Transcriptional regulator
P12B_RS22540	COG2194	sulfuric ester hydrolase activity
P12B_RS22555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
P12B_RS22570	COG0583	DNA-binding transcription factor activity
P12B_RS22595	COG4206	TonB-dependent receptor
P12B_RS22630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
P12B_RS22630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
P12B_RS22670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
P12B_RS22675	COG0250	Participates in transcription elongation, termination and antitermination
P12B_RS22715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P12B_RS22725	COG2104	thiamine diphosphate biosynthetic process
P12B_RS22730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P12B_RS22765	COG3068	Protein conserved in bacteria
P12B_RS22780	COG3678	ATP-independent chaperone mediated protein folding
P12B_RS22785	COG4191	Histidine kinase
P12B_RS22790	COG2204	response regulator
P12B_RS22795	COG0151	Belongs to the GarS family
P12B_RS22825	COG0456	acetyltransferase
P12B_RS22835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
P12B_RS22840	COG2224	Isocitrate lyase
P12B_RS22855	COG1414	Transcriptional regulator
P12B_RS22860	COG0646	methionine synthase
P12B_RS22860	COG1410	methionine synthase
P12B_RS22865	COG1283	sodium-dependent phosphate transmembrane transporter activity
P12B_RS22875	COG1187	pseudouridine synthase activity
P12B_RS22885	COG0527	aspartate kinase activity
P12B_RS22910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P12B_RS22935	COG0477	Major facilitator Superfamily
P12B_RS22935	COG2814	Major facilitator Superfamily
P12B_RS22940	COG3833	ABC-type maltose transport systems, permease component
P12B_RS22945	COG1175	transmembrane transport
P12B_RS22950	COG2182	Extracellular solute-binding protein
P12B_RS22960	COG3842	ATPase activity
P12B_RS22980	COG1357	PFAM Pentapeptide repeats (8 copies)
P12B_RS23000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
P12B_RS23010	COG0534	Mate efflux family protein
P12B_RS23015	COG3237	CsbD-like
P12B_RS23020	COG0735	belongs to the Fur family
P12B_RS23035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P12B_RS23045	COG0604	alcohol dehydrogenase
P12B_RS23050	COG0305	Participates in initiation and elongation during chromosome replication
P12B_RS23055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
P12B_RS23060	COG1448	Aminotransferase
P12B_RS23070	COG3700	Belongs to the class B bacterial acid phosphatase family
P12B_RS23075	COG0432	Pfam Uncharacterised protein family UPF0047
P12B_RS23080	COG2315	Protein conserved in bacteria
P12B_RS23085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
P12B_RS23090	COG0629	single-stranded DNA binding
P12B_RS23115	COG1002	Type II restriction enzyme, methylase subunits
P12B_RS23120	COG1061	Type III restriction enzyme res subunit
P12B_RS23125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P12B_RS23135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
P12B_RS23140	COG2207	Transcriptional regulator
P12B_RS23145	COG0789	Transcriptional regulator
P12B_RS23150	COG2252	PERMEase
P12B_RS23155	COG0025	NhaP-type Na H and K H
P12B_RS23160	COG1357	PFAM Pentapeptide repeats (8 copies)
P12B_RS23170	COG3162	membrane
P12B_RS23175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P12B_RS23185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
P12B_RS23190	COG0437	4 iron, 4 sulfur cluster binding
P12B_RS23195	COG3301	Polysulphide reductase, NrfD
P12B_RS23200	COG1138	Cytochrome C-type biogenesis protein
P12B_RS23205	COG3088	subunit of a heme lyase
P12B_RS23210	COG4235	cytochrome complex assembly
P12B_RS23215	COG1301	dicarboxylic acid transport
P12B_RS23220	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
P12B_RS23225	COG3383	formate dehydrogenase (NAD+) activity
P12B_RS23230	COG3383	formate dehydrogenase (NAD+) activity
P12B_RS23240	COG1289	transmembrane transporter activity
P12B_RS23245	COG1566	PFAM secretion protein HlyD family protein
P12B_RS23255	COG2015	COG2015, Alkyl sulfatase and related hydrolases
P12B_RS23260	COG0698	ribose 5-phosphate isomerase
P12B_RS23270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
P12B_RS23275	COG0456	acetyltransferase
P12B_RS23280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
P12B_RS23285	COG3454	Phosphonate metabolism
P12B_RS23290	COG4778	phosphonate C-P lyase system protein PhnL
P12B_RS23295	COG4107	phosphonate C-P lyase system protein PhnK
P12B_RS23300	COG3627	carbon phosphorus lyase activity
P12B_RS23305	COG3626	phosphonate metabolism
P12B_RS23310	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
P12B_RS23315	COG3624	Phosphonate C-P lyase system protein PhnG
P12B_RS23320	COG2188	Transcriptional regulator
P12B_RS23325	COG3639	organic phosphonate transmembrane transporter activity
P12B_RS23340	COG2764	glyoxalase bleomycin resistance protein dioxygenase
P12B_RS23345	COG2824	Alkylphosphonate utilization operon protein PhnA
P12B_RS23350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
P12B_RS23360	COG0477	Major facilitator Superfamily
P12B_RS23370	COG0642	Histidine kinase
P12B_RS23375	COG0745	RESPONSE REGULATOR receiver
P12B_RS23380	COG2194	sulfuric ester hydrolase activity
P12B_RS23385	COG0531	amino acid
P12B_RS23390	COG2207	Transcriptional regulator
P12B_RS23395	COG1982	Orn Lys Arg decarboxylase major
P12B_RS23400	COG2169	Transcriptional regulator
P12B_RS23410	COG1486	melibiose metabolic process
P12B_RS23415	COG2211	Major facilitator Superfamily
P12B_RS23420	COG3647	Membrane
P12B_RS23425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
P12B_RS23425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
P12B_RS23440	COG4565	transcriptional regulatory protein
P12B_RS23445	COG3290	protein histidine kinase activity
P12B_RS23450	COG3592	Divergent 4Fe-4S mono-cluster
P12B_RS23455	COG2388	GCN5-related N-acetyl-transferase
P12B_RS23470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P12B_RS23475	COG3104	oligopeptide transport
P12B_RS23480	COG1982	Orn Lys Arg decarboxylase major
P12B_RS23485	COG0531	amino acid
P12B_RS23490	COG3710	Transcriptional regulator
P12B_RS23500	COG1309	transcriptional regulator
P12B_RS23515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
P12B_RS23520	COG1027	Aspartate ammonia-lyase
P12B_RS23525	COG3030	protein affecting phage T7 exclusion by the F plasmid
P12B_RS23530	COG0531	amino acid
P12B_RS23555	COG1509	lysine 2,3-aminomutase activity
P12B_RS23565	COG5510	response to toxic substance
P12B_RS23570	COG5510	response to toxic substance
P12B_RS23575	COG2076	Multidrug Resistance protein
P12B_RS23580	COG3040	lipid binding
P12B_RS23585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
P12B_RS23600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
P12B_RS23605	COG1053	succinate dehydrogenase
P12B_RS23615	COG0531	amino acid
P12B_RS23620	COG1511	domain protein
P12B_RS23620	COG3264	Mechanosensitive ion channel
P12B_RS23655	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
P12B_RS23660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P12B_RS23660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P12B_RS23665	COG0802	atpase or kinase
P12B_RS23670	COG0860	N-Acetylmuramoyl-L-alanine amidase
P12B_RS23690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
P12B_RS23695	COG0330	HflC and HflK could
P12B_RS23700	COG0330	HflC and HflK could
P12B_RS23705	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
P12B_RS23720	COG0557	exoribonuclease II activity
P12B_RS23725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P12B_RS23730	COG1414	Transcriptional regulator
P12B_RS23735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P12B_RS23740	COG2271	Major facilitator Superfamily
P12B_RS23745	COG2721	sulfolactate sulfo-lyase activity
P12B_RS23750	COG3789	protein conserved in bacteria
P12B_RS23755	COG1842	Phage shock protein A
P12B_RS23765	COG3766	membrane
P12B_RS23770	COG5463	Belongs to the UPF0441 family
P12B_RS23775	COG0754	glutathionylspermidine amidase activity
P12B_RS23780	COG1960	acyl-CoA dehydrogenase activity
P12B_RS23790	COG3650	response to hydrogen peroxide
P12B_RS23795	COG1073	alpha beta
P12B_RS23810	COG3037	sugar-specific permease SgaT UlaA
P12B_RS23815	COG3414	Phosphotransferase system galactitol-specific IIB component
P12B_RS23860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P12B_RS23870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
P12B_RS23885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
P12B_RS23890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
P12B_RS23895	COG4670	ketone body catabolic process
P12B_RS23900	COG1024	Enoyl-CoA hydratase
P12B_RS23915	COG1309	transcriptional regulator
P12B_RS23920	COG3061	Opacity-associated protein A
P12B_RS23925	COG0545	Peptidyl-prolyl cis-trans isomerase
P12B_RS23930	COG1113	amino acid transport
P12B_RS23940	COG0697	spore germination
P12B_RS23950	COG1733	regulation of RNA biosynthetic process
P12B_RS23955	COG0737	Belongs to the 5'-nucleotidase family
P12B_RS23960	COG1218	3'(2'),5'-bisphosphate nucleotidase
P12B_RS23990	COG0729	surface antigen
P12B_RS23995	COG2911	Protein conserved in bacteria
P12B_RS24000	COG2105	PFAM AIG2 family protein
P12B_RS24005	COG2336	PFAM SpoVT AbrB
P12B_RS24010	COG2337	Toxic component of a toxin-antitoxin (TA) module
P12B_RS24015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P12B_RS24020	COG1879	ABC-type sugar transport system periplasmic component
P12B_RS24030	COG1172	Belongs to the binding-protein-dependent transport system permease family
P12B_RS24035	COG1172	Belongs to the binding-protein-dependent transport system permease family
P12B_RS24045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P12B_RS24055	COG0312	modulator of DNA gyrase
P12B_RS24060	COG3783	Cytochrome b(562)
P12B_RS24065	COG0602	queuosine metabolic process
P12B_RS24075	COG0366	Alpha amylase catalytic
P12B_RS24080	COG1263	PTS System
P12B_RS24080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS24085	COG1263	PTS System
P12B_RS24085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
P12B_RS24090	COG1609	Transcriptional regulator
P12B_RS24095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
P12B_RS24100	COG0251	oxidation-reduction process
P12B_RS24125	COG0251	oxidation-reduction process
P12B_RS24130	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS24135	COG1309	transcriptional regulator
P12B_RS24140	COG2731	YhcH YjgK YiaL family protein
P12B_RS24155	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
P12B_RS24160	COG0456	acetyltransferase
P12B_RS24165	COG4269	membrane
P12B_RS24175	COG4269	membrane
P12B_RS24180	COG0525	valine-tRNA ligase activity
P12B_RS24185	COG2927	DNA polymerase III (CHI subunit)
P12B_RS24195	COG0795	lipopolysaccharide-transporting ATPase activity
P12B_RS24200	COG0795	lipopolysaccharide-transporting ATPase activity
P12B_RS24205	COG0433	COG0433 Predicted ATPase
P12B_RS24210	COG1609	Transcriptional regulator
P12B_RS24215	COG2610	gluconate transmembrane transporter activity
P12B_RS24220	COG1028	Short-chain dehydrogenase reductase Sdr
P12B_RS24225	COG1063	alcohol dehydrogenase
P12B_RS24230	COG3265	gluconokinase activity
P12B_RS24235	COG1064	alcohol dehydrogenase
P12B_RS24245	COG0582	viral genome integration into host DNA
P12B_RS24275	COG3385	transposase activity
P12B_RS24290	COG0673	inositol 2-dehydrogenase activity
P12B_RS24310	COG2801	Transposase and inactivated derivatives
P12B_RS24325	COG2085	NADP oxidoreductase coenzyme F420-dependent
P12B_RS24340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
P12B_RS24345	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
P12B_RS24350	COG4772	TonB-dependent receptor
P12B_RS24355	COG3712	iron ion homeostasis
P12B_RS24360	COG1595	DNA-templated transcription, initiation
P12B_RS24390	COG3188	usher protein
P12B_RS24395	COG3539	Fimbrial protein
P12B_RS24400	COG3539	Fimbrial protein
P12B_RS24410	COG2610	gluconate transmembrane transporter activity
P12B_RS24425	COG0246	Mannitol dehydrogenase
P12B_RS24435	COG2186	Transcriptional regulator
P12B_RS24460	COG0583	DNA-binding transcription factor activity
P12B_RS24465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
P12B_RS24470	COG0700	Nucleoside recognition
P12B_RS24485	COG0477	Major facilitator Superfamily
P12B_RS24500	COG1924	4 iron, 4 sulfur cluster binding
P12B_RS24505	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
P12B_RS24510	COG2733	membrane
P12B_RS24515	COG2814	Major facilitator Superfamily
P12B_RS24525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
P12B_RS24530	COG5457	Domain of unknown function (DUF1127)
P12B_RS24545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
P12B_RS24550	COG0732	type I restriction modification DNA specificity domain
P12B_RS24555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
P12B_RS24560	COG1715	Restriction endonuclease
P12B_RS24575	COG0523	cobalamin synthesis protein
P12B_RS24580	COG2879	small protein
P12B_RS24585	COG1966	Carbon starvation protein
P12B_RS24595	COG0840	transmembrane signaling receptor activity
P12B_RS24600	COG2271	Major facilitator Superfamily
P12B_RS24605	COG1802	Transcriptional regulator
P12B_RS24610	COG1063	alcohol dehydrogenase
P12B_RS24625	COG1484	DNA-dependent DNA replication
P12B_RS24640	COG2966	Psort location CytoplasmicMembrane, score
P12B_RS24645	COG2197	response regulator
P12B_RS24650	COG2197	response regulator
P12B_RS24655	COG4114	ferric iron reductase
P12B_RS24690	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
P12B_RS24695	COG0456	acetyltransferase
P12B_RS24700	COG1011	Hydrolase
P12B_RS24710	COG2823	Periplasmic or secreted lipoprotein
P12B_RS24720	COG4667	esterase of the alpha-beta hydrolase superfamily
P12B_RS24725	COG0084	hydrolase, TatD family'
P12B_RS24730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
P12B_RS24735	COG1328	CTP reductase activity
P12B_RS24765	COG3550	peptidyl-serine autophosphorylation
P12B_RS24775	COG3726	membrane protein affecting hemolysin expression
P12B_RS24780	COG0560	Phosphoserine phosphatase
P12B_RS24785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
P12B_RS24790	COG3172	ATPase kinase involved in NAD metabolism
P12B_RS24790	COG1056	cytidyltransferase-related domain
P12B_RS24800	COG0488	(ABC) transporter
P12B_RS24805	COG0741	lytic transglycosylase activity
P12B_RS24825	COG2207	Transcriptional regulator
P12B_RS24825	COG3708	Transcriptional regulator
P12B_RS24830	COG3045	CreA protein
P12B_RS24835	COG0745	RESPONSE REGULATOR receiver
P12B_RS24840	COG2205	protein histidine kinase activity
P12B_RS24845	COG4452	Inner membrane protein CreD
P12B_RS24850	COG0745	RESPONSE REGULATOR receiver
P12B_RS24860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
P12B_RS24925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P12B_RS24930	COG3210	domain, Protein
P12B_RS24930	COG2911	Protein conserved in bacteria