locus-tag	class	description
D0T88_RS00025	COG4695	Portal protein
D0T88_RS00110	COG5301	cellulose 1,4-beta-cellobiosidase activity
D0T88_RS00175	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS00180	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D0T88_RS00200	COG3152	Membrane
D0T88_RS00205	COG3691	Protein conserved in bacteria
D0T88_RS00210	COG0589	response to stress
D0T88_RS00220	COG1494	fructose-1,6-bisphosphatase
D0T88_RS00230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0T88_RS00245	COG1575	Belongs to the MenA family. Type 1 subfamily
D0T88_RS00260	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0T88_RS00265	COG1609	Transcriptional regulator
D0T88_RS00270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0T88_RS00295	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
D0T88_RS00305	COG0626	cystathionine gamma-synthase activity
D0T88_RS00310	COG0460	homoserine dehydrogenase
D0T88_RS00310	COG0527	aspartate kinase activity
D0T88_RS00315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0T88_RS00325	COG0697	spore germination
D0T88_RS00330	COG3738	Protein conserved in bacteria
D0T88_RS00335	COG0371	Dehydrogenase
D0T88_RS00340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0T88_RS00345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS00345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS00345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0T88_RS00350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS00355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS00360	COG1882	Formate acetyltransferase
D0T88_RS00365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0T88_RS00370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS00375	COG2207	Transcriptional regulator
D0T88_RS00380	COG2194	sulfuric ester hydrolase activity
D0T88_RS00395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0T88_RS00410	COG4948	Mandelate Racemase Muconate Lactonizing
D0T88_RS00415	COG2271	Major facilitator Superfamily
D0T88_RS00420	COG0583	DNA-binding transcription factor activity
D0T88_RS00430	COG1309	transcriptional regulator
D0T88_RS00480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D0T88_RS00480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D0T88_RS00515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0T88_RS00520	COG0250	Participates in transcription elongation, termination and antitermination
D0T88_RS00555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0T88_RS00565	COG2104	thiamine diphosphate biosynthetic process
D0T88_RS00570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0T88_RS00605	COG3068	Protein conserved in bacteria
D0T88_RS00620	COG3678	ATP-independent chaperone mediated protein folding
D0T88_RS00625	COG4191	Histidine kinase
D0T88_RS00630	COG2204	response regulator
D0T88_RS00635	COG0151	Belongs to the GarS family
D0T88_RS00665	COG0456	acetyltransferase
D0T88_RS00675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0T88_RS00680	COG2224	Isocitrate lyase
D0T88_RS00695	COG1414	Transcriptional regulator
D0T88_RS00700	COG0646	methionine synthase
D0T88_RS00700	COG1410	methionine synthase
D0T88_RS00705	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0T88_RS00715	COG1187	pseudouridine synthase activity
D0T88_RS00730	COG3541	Predicted nucleotidyltransferase
D0T88_RS00735	COG0542	response to heat
D0T88_RS00740	COG0527	aspartate kinase activity
D0T88_RS00765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0T88_RS00780	COG2814	Major facilitator Superfamily
D0T88_RS00780	COG0477	Major facilitator Superfamily
D0T88_RS00785	COG3833	ABC-type maltose transport systems, permease component
D0T88_RS00790	COG1175	transmembrane transport
D0T88_RS00795	COG2182	Extracellular solute-binding protein
D0T88_RS00800	COG3842	ATPase activity
D0T88_RS00835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0T88_RS00845	COG0534	Mate efflux family protein
D0T88_RS00850	COG3237	CsbD-like
D0T88_RS00855	COG0735	belongs to the Fur family
D0T88_RS00865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0T88_RS00875	COG0604	alcohol dehydrogenase
D0T88_RS00880	COG0305	Participates in initiation and elongation during chromosome replication
D0T88_RS00885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0T88_RS00890	COG1448	Aminotransferase
D0T88_RS00900	COG3700	Belongs to the class B bacterial acid phosphatase family
D0T88_RS00905	COG0432	Pfam Uncharacterised protein family UPF0047
D0T88_RS00910	COG2315	Protein conserved in bacteria
D0T88_RS00915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0T88_RS00920	COG0629	single-stranded DNA binding
D0T88_RS00930	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0T88_RS00935	COG2207	Transcriptional regulator
D0T88_RS00940	COG0789	Transcriptional regulator
D0T88_RS00945	COG2252	PERMEase
D0T88_RS00950	COG0025	NhaP-type Na H and K H
D0T88_RS00955	COG1357	PFAM Pentapeptide repeats (8 copies)
D0T88_RS00965	COG3162	membrane
D0T88_RS00970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0T88_RS00980	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D0T88_RS00985	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS00990	COG3301	Polysulphide reductase, NrfD
D0T88_RS00995	COG1138	Cytochrome C-type biogenesis protein
D0T88_RS01000	COG3088	subunit of a heme lyase
D0T88_RS01005	COG4235	cytochrome complex assembly
D0T88_RS01010	COG1301	dicarboxylic acid transport
D0T88_RS01015	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0T88_RS01030	COG1289	transmembrane transporter activity
D0T88_RS01035	COG1566	PFAM secretion protein HlyD family protein
D0T88_RS01045	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D0T88_RS01050	COG1940	carbohydrate kinase activity
D0T88_RS01055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0T88_RS01060	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS01065	COG1129	ABC transporter
D0T88_RS01070	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS01075	COG1737	Transcriptional regulator
D0T88_RS01080	COG0698	ribose 5-phosphate isomerase
D0T88_RS01090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D0T88_RS01095	COG0456	acetyltransferase
D0T88_RS01100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D0T88_RS01105	COG3454	Phosphonate metabolism
D0T88_RS01110	COG4778	phosphonate C-P lyase system protein PhnL
D0T88_RS01115	COG4107	phosphonate C-P lyase system protein PhnK
D0T88_RS01120	COG3627	carbon phosphorus lyase activity
D0T88_RS01125	COG3626	phosphonate metabolism
D0T88_RS01130	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D0T88_RS01135	COG3624	Phosphonate C-P lyase system protein PhnG
D0T88_RS01140	COG2188	Transcriptional regulator
D0T88_RS01145	COG3639	organic phosphonate transmembrane transporter activity
D0T88_RS01150	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D0T88_RS01160	COG2764	glyoxalase bleomycin resistance protein dioxygenase
D0T88_RS01165	COG2824	Alkylphosphonate utilization operon protein PhnA
D0T88_RS01180	COG0477	Major facilitator Superfamily
D0T88_RS01190	COG0642	Histidine kinase
D0T88_RS01195	COG0745	RESPONSE REGULATOR receiver
D0T88_RS01200	COG2194	sulfuric ester hydrolase activity
D0T88_RS01205	COG0531	amino acid
D0T88_RS01210	COG2207	Transcriptional regulator
D0T88_RS01215	COG1982	Orn Lys Arg decarboxylase major
D0T88_RS01220	COG2169	Transcriptional regulator
D0T88_RS01225	COG1486	melibiose metabolic process
D0T88_RS01230	COG2211	Major facilitator Superfamily
D0T88_RS01235	COG3647	Membrane
D0T88_RS01240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0T88_RS01240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0T88_RS01245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0T88_RS01250	COG4565	transcriptional regulatory protein
D0T88_RS01255	COG3290	protein histidine kinase activity
D0T88_RS01260	COG3592	Divergent 4Fe-4S mono-cluster
D0T88_RS01265	COG2388	GCN5-related N-acetyl-transferase
D0T88_RS01280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0T88_RS01285	COG3104	oligopeptide transport
D0T88_RS01290	COG1982	Orn Lys Arg decarboxylase major
D0T88_RS01295	COG0531	amino acid
D0T88_RS01300	COG3710	Transcriptional regulator
D0T88_RS01310	COG1309	transcriptional regulator
D0T88_RS01325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0T88_RS01330	COG1027	Aspartate ammonia-lyase
D0T88_RS01335	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0T88_RS01340	COG0531	amino acid
D0T88_RS01360	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS01370	COG1509	lysine 2,3-aminomutase activity
D0T88_RS01380	COG5510	response to toxic substance
D0T88_RS01385	COG5510	response to toxic substance
D0T88_RS01390	COG2076	Multidrug Resistance protein
D0T88_RS01395	COG3040	lipid binding
D0T88_RS01400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0T88_RS01415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0T88_RS01420	COG1053	succinate dehydrogenase
D0T88_RS01430	COG0531	amino acid
D0T88_RS01435	COG3264	Mechanosensitive ion channel
D0T88_RS01435	COG1511	domain protein
D0T88_RS01475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0T88_RS01480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0T88_RS01480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0T88_RS01485	COG0802	atpase or kinase
D0T88_RS01490	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0T88_RS01510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0T88_RS01515	COG0330	HflC and HflK could
D0T88_RS01520	COG0330	HflC and HflK could
D0T88_RS01525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0T88_RS01540	COG0557	exoribonuclease II activity
D0T88_RS01545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0T88_RS01550	COG3789	protein conserved in bacteria
D0T88_RS01555	COG1842	Phage shock protein A
D0T88_RS01565	COG3766	membrane
D0T88_RS01570	COG5463	Belongs to the UPF0441 family
D0T88_RS01575	COG0754	glutathionylspermidine amidase activity
D0T88_RS01580	COG1960	acyl-CoA dehydrogenase activity
D0T88_RS01590	COG3650	response to hydrogen peroxide
D0T88_RS01595	COG1073	alpha beta
D0T88_RS01610	COG3037	sugar-specific permease SgaT UlaA
D0T88_RS01655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0T88_RS01665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0T88_RS01675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0T88_RS01680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0T88_RS01685	COG4670	ketone body catabolic process
D0T88_RS01690	COG1024	Enoyl-CoA hydratase
D0T88_RS01705	COG1309	transcriptional regulator
D0T88_RS01710	COG3061	Opacity-associated protein A
D0T88_RS01715	COG0545	Peptidyl-prolyl cis-trans isomerase
D0T88_RS01720	COG1113	amino acid transport
D0T88_RS01730	COG0697	spore germination
D0T88_RS01735	COG0702	epimerase
D0T88_RS01740	COG1733	regulation of RNA biosynthetic process
D0T88_RS01745	COG0737	Belongs to the 5'-nucleotidase family
D0T88_RS01750	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0T88_RS01755	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0T88_RS01765	COG1253	flavin adenine dinucleotide binding
D0T88_RS01775	COG0729	surface antigen
D0T88_RS01780	COG2911	Protein conserved in bacteria
D0T88_RS01785	COG2105	PFAM AIG2 family protein
D0T88_RS01790	COG2336	PFAM SpoVT AbrB
D0T88_RS01795	COG2337	Toxic component of a toxin-antitoxin (TA) module
D0T88_RS01800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0T88_RS01805	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS01810	COG1129	ABC transporter
D0T88_RS01815	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS01820	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS01830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0T88_RS01840	COG0312	modulator of DNA gyrase
D0T88_RS01845	COG3783	Cytochrome b(562)
D0T88_RS01850	COG0602	queuosine metabolic process
D0T88_RS01855	COG1328	CTP reductase activity
D0T88_RS01860	COG0366	Alpha amylase catalytic
D0T88_RS01865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS01865	COG1263	PTS System
D0T88_RS01870	COG1609	Transcriptional regulator
D0T88_RS01880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0T88_RS01885	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS01890	COG0251	oxidation-reduction process
D0T88_RS01910	COG0251	oxidation-reduction process
D0T88_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS01920	COG1309	transcriptional regulator
D0T88_RS01925	COG2731	YhcH YjgK YiaL family protein
D0T88_RS01945	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D0T88_RS01950	COG0456	acetyltransferase
D0T88_RS01955	COG4269	membrane
D0T88_RS01960	COG0525	valine-tRNA ligase activity
D0T88_RS01965	COG2927	DNA polymerase III (CHI subunit)
D0T88_RS01975	COG0795	lipopolysaccharide-transporting ATPase activity
D0T88_RS01980	COG0795	lipopolysaccharide-transporting ATPase activity
D0T88_RS01985	COG0433	COG0433 Predicted ATPase
D0T88_RS01990	COG1609	Transcriptional regulator
D0T88_RS01995	COG2610	gluconate transmembrane transporter activity
D0T88_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS02005	COG1063	alcohol dehydrogenase
D0T88_RS02010	COG3265	gluconokinase activity
D0T88_RS02015	COG1064	alcohol dehydrogenase
D0T88_RS02065	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D0T88_RS02070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0T88_RS02075	COG0582	viral genome integration into host DNA
D0T88_RS02080	COG4974	Belongs to the 'phage' integrase family
D0T88_RS02085	COG3539	Fimbrial protein
D0T88_RS02090	COG3539	Fimbrial protein
D0T88_RS02095	COG3121	Chaperone
D0T88_RS02100	COG3188	usher protein
D0T88_RS02105	COG3539	Fimbrial protein
D0T88_RS02110	COG3539	Fimbrial protein
D0T88_RS02115	COG3539	Fimbrial protein
D0T88_RS02120	COG2610	gluconate transmembrane transporter activity
D0T88_RS02130	COG0246	Mannitol dehydrogenase
D0T88_RS02135	COG2186	Transcriptional regulator
D0T88_RS02155	COG0583	DNA-binding transcription factor activity
D0T88_RS02160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0T88_RS02165	COG0700	Nucleoside recognition
D0T88_RS02170	COG3366	ferrous iron transmembrane transporter activity
D0T88_RS02180	COG0477	Major facilitator Superfamily
D0T88_RS02195	COG1924	4 iron, 4 sulfur cluster binding
D0T88_RS02200	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
D0T88_RS02205	COG2733	membrane
D0T88_RS02210	COG2814	Major facilitator Superfamily
D0T88_RS02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0T88_RS02225	COG5457	Domain of unknown function (DUF1127)
D0T88_RS02235	COG0523	cobalamin synthesis protein
D0T88_RS02240	COG2879	small protein
D0T88_RS02245	COG1966	Carbon starvation protein
D0T88_RS02250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0T88_RS02255	COG2368	4-hydroxyphenylacetate
D0T88_RS02275	COG3971	2-oxopent-4-enoate hydratase activity
D0T88_RS02285	COG3384	dioxygenase
D0T88_RS02290	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS02295	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0T88_RS02300	COG1846	Transcriptional regulator
D0T88_RS02305	COG0840	transmembrane signaling receptor activity
D0T88_RS02310	COG2271	Major facilitator Superfamily
D0T88_RS02315	COG1802	Transcriptional regulator
D0T88_RS02320	COG1063	alcohol dehydrogenase
D0T88_RS02335	COG1484	DNA-dependent DNA replication
D0T88_RS02350	COG2966	Psort location CytoplasmicMembrane, score
D0T88_RS02355	COG2197	response regulator
D0T88_RS02360	COG2197	response regulator
D0T88_RS02365	COG4114	ferric iron reductase
D0T88_RS02395	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D0T88_RS02400	COG0456	acetyltransferase
D0T88_RS02405	COG1011	Hydrolase
D0T88_RS02430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D0T88_RS02435	COG5532	Uncharacterized conserved protein (DUF2303)
D0T88_RS02445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0T88_RS02450	COG4197	protein conserved in bacteria, prophage-related
D0T88_RS02470	COG1846	Transcriptional regulator
D0T88_RS02480	COG4725	Belongs to the MT-A70-like family
D0T88_RS02490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
D0T88_RS02500	COG1403	HNH endonuclease
D0T88_RS02535	COG4372	Transposase
D0T88_RS02540	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS02580	COG4695	Portal protein
D0T88_RS02665	COG0727	PFAM Uncharacterised protein family (UPF0153)
D0T88_RS02690	COG2823	Periplasmic or secreted lipoprotein
D0T88_RS02700	COG4667	esterase of the alpha-beta hydrolase superfamily
D0T88_RS02705	COG0084	hydrolase, TatD family'
D0T88_RS02710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0T88_RS02715	COG1328	CTP reductase activity
D0T88_RS02750	COG3726	membrane protein affecting hemolysin expression
D0T88_RS02755	COG0560	Phosphoserine phosphatase
D0T88_RS02760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0T88_RS02765	COG1056	cytidyltransferase-related domain
D0T88_RS02765	COG3172	ATPase kinase involved in NAD metabolism
D0T88_RS02770	COG0488	(ABC) transporter
D0T88_RS02775	COG0741	lytic transglycosylase activity
D0T88_RS02795	COG3708	Transcriptional regulator
D0T88_RS02795	COG2207	Transcriptional regulator
D0T88_RS02800	COG3045	CreA protein
D0T88_RS02805	COG0745	RESPONSE REGULATOR receiver
D0T88_RS02810	COG2205	protein histidine kinase activity
D0T88_RS02815	COG4452	Inner membrane protein CreD
D0T88_RS02820	COG0745	RESPONSE REGULATOR receiver
D0T88_RS02830	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D0T88_RS02840	COG0460	homoserine dehydrogenase
D0T88_RS02840	COG0527	aspartate kinase activity
D0T88_RS02850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0T88_RS02860	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS02870	COG1115	amino acid carrier protein
D0T88_RS02880	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0T88_RS02885	COG1584	GPR1 FUN34 yaaH family protein
D0T88_RS02890	COG4735	regulation of single-species biofilm formation
D0T88_RS02920	COG0583	DNA-binding transcription factor activity
D0T88_RS02950	COG0196	riboflavin kinase activity
D0T88_RS02965	COG1047	Peptidyl-prolyl cis-trans
D0T88_RS02985	COG0505	Belongs to the CarA family
D0T88_RS02990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0T88_RS03040	COG0644	oxidoreductase
D0T88_RS03045	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D0T88_RS03050	COG2271	Major facilitator Superfamily
D0T88_RS03065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0T88_RS03090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0T88_RS03095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0T88_RS03100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0T88_RS03105	COG0564	pseudouridine synthase activity
D0T88_RS03115	COG0417	DNA replication proofreading
D0T88_RS03120	COG0235	Class ii aldolase
D0T88_RS03135	COG4977	sequence-specific DNA binding
D0T88_RS03140	COG0586	Pfam SNARE associated Golgi protein
D0T88_RS03150	COG1178	ABC-type Fe3 transport system permease component
D0T88_RS03155	COG4143	(ABC) transporter
D0T88_RS03170	COG2814	Major facilitator Superfamily
D0T88_RS03185	COG0473	3-isopropylmalate dehydrogenase activity
D0T88_RS03200	COG0583	DNA-binding transcription factor activity
D0T88_RS03210	COG0028	Belongs to the TPP enzyme family
D0T88_RS03215	COG0440	acetolactate synthase activity
D0T88_RS03225	COG1609	Transcriptional regulator
D0T88_RS03240	COG3116	cell division
D0T88_RS03245	COG0768	penicillin binding
D0T88_RS03250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0T88_RS03255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0T88_RS03270	COG0772	Belongs to the SEDS family
D0T88_RS03285	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0T88_RS03290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0T88_RS03295	COG0849	cell division
D0T88_RS03300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0T88_RS03320	COG0494	nUDIX hydrolase
D0T88_RS03335	COG0237	dephospho-CoA kinase activity
D0T88_RS03350	COG1459	type II secretion system
D0T88_RS03355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0T88_RS03360	COG4969	Belongs to the N-Me-Phe pilin family
D0T88_RS03365	COG0157	Belongs to the NadC ModD family
D0T88_RS03370	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0T88_RS03375	COG3725	Membrane protein required for beta-lactamase induction
D0T88_RS03380	COG1113	amino acid transport
D0T88_RS03385	COG2186	Transcriptional regulator
D0T88_RS03390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0T88_RS03395	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0T88_RS03400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0T88_RS03405	COG3064	Membrane
D0T88_RS03410	COG1049	propionate catabolic process, 2-methylcitrate cycle
D0T88_RS03435	COG2132	Multicopper oxidase
D0T88_RS03440	COG4993	Dehydrogenase
D0T88_RS03445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D0T88_RS03450	COG0288	reversible hydration of carbon dioxide
D0T88_RS03455	COG1131	(ABC) transporter
D0T88_RS03460	COG0842	Transport permease protein
D0T88_RS03465	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS03470	COG0726	polysaccharide deacetylase
D0T88_RS03480	COG5464	transposase or invertase
D0T88_RS03495	COG3539	Fimbrial protein
D0T88_RS03500	COG3539	Fimbrial protein
D0T88_RS03505	COG3539	Fimbrial protein
D0T88_RS03510	COG3539	Fimbrial protein
D0T88_RS03515	COG3188	usher protein
D0T88_RS03520	COG3121	Chaperone
D0T88_RS03525	COG3539	Fimbrial protein
D0T88_RS03530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0T88_RS03535	COG0617	tRNA 3'-terminal CCA addition
D0T88_RS03545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0T88_RS03555	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D0T88_RS03560	COG1643	Atp-dependent helicase
D0T88_RS03565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0T88_RS03570	COG4774	siderophore transport
D0T88_RS03575	COG1120	ATPase activity
D0T88_RS03580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0T88_RS03585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0T88_RS03610	COG2860	membrane
D0T88_RS03615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0T88_RS03630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0T88_RS03635	COG3835	regulator
D0T88_RS03655	COG0024	Methionine aminopeptidase
D0T88_RS03680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0T88_RS03685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0T88_RS03690	COG0575	Belongs to the CDS family
D0T88_RS03695	COG0750	zinc metalloprotease
D0T88_RS03705	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0T88_RS03710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0T88_RS03735	COG0587	DNA-directed DNA polymerase activity
D0T88_RS03745	COG1982	Orn Lys Arg decarboxylase major
D0T88_RS03750	COG0346	lactoylglutathione lyase activity
D0T88_RS03760	COG4568	rho-dependent transcription termination
D0T88_RS03770	COG4681	YaeQ
D0T88_RS03775	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0T88_RS03780	COG3015	lipoprotein NlpE involved in copper resistance
D0T88_RS03785	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS03790	COG0791	NLP P60 protein
D0T88_RS03800	COG1720	tRNA m6t6A37 methyltransferase activity
D0T88_RS03810	COG1464	Belongs to the NlpA lipoprotein family
D0T88_RS03815	COG2011	ABC-type metal ion transport system permease component
D0T88_RS03820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0T88_RS03825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0T88_RS03860	COG0656	L-ascorbic acid biosynthetic process
D0T88_RS03865	COG0583	DNA-binding transcription factor activity
D0T88_RS03875	COG2226	methyltransferase
D0T88_RS03880	COG0741	lytic transglycosylase activity
D0T88_RS03880	COG1388	LysM domain
D0T88_RS03890	COG2226	methyltransferase
D0T88_RS03900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0T88_RS03920	COG4104	PAAR repeat-containing protein
D0T88_RS03925	COG3157	Type VI secretion system effector, Hcp
D0T88_RS04015	COG3209	COG3209 Rhs family protein
D0T88_RS04040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0T88_RS04050	COG1960	acyl-CoA dehydrogenase activity
D0T88_RS04060	COG0121	glutamine amidotransferase
D0T88_RS04065	COG3034	peptidoglycan biosynthetic process
D0T88_RS04070	COG3041	Addiction module toxin RelE StbE family
D0T88_RS04075	COG3077	Addiction module antitoxin, RelB DinJ family
D0T88_RS04080	COG0791	NLP P60 protein
D0T88_RS04110	COG0454	-acetyltransferase
D0T88_RS04115	COG1690	Belongs to the RtcB family
D0T88_RS04120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0T88_RS04125	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0T88_RS04165	COG0583	DNA-binding transcription factor activity
D0T88_RS04170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D0T88_RS04175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0T88_RS04180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0T88_RS04185	COG2080	2 iron, 2 sulfur cluster binding
D0T88_RS04190	COG3477	response to acidic pH
D0T88_RS04195	COG0727	PFAM Uncharacterised protein family (UPF0153)
D0T88_RS04200	COG3121	Chaperone
D0T88_RS04210	COG3188	usher protein
D0T88_RS04250	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS04255	COG1388	LysM domain
D0T88_RS04260	COG2207	Transcriptional regulator
D0T88_RS04260	COG3708	Transcriptional regulator
D0T88_RS04265	COG0656	L-ascorbic acid biosynthetic process
D0T88_RS04270	COG3059	membrane
D0T88_RS04280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0T88_RS04285	COG2207	Transcriptional regulator
D0T88_RS04290	COG0247	lactate metabolic process
D0T88_RS04295	COG1139	Iron-sulfur cluster binding protein
D0T88_RS04300	COG1556	Lactate utilization protein
D0T88_RS04325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0T88_RS04335	COG2200	EAL domain
D0T88_RS04335	COG2771	luxR family
D0T88_RS04340	COG0583	DNA-binding transcription factor activity
D0T88_RS04350	COG0666	response to abiotic stimulus
D0T88_RS04360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0T88_RS04365	COG1304	FMN binding
D0T88_RS04370	COG0549	Belongs to the carbamate kinase family
D0T88_RS04375	COG0402	S-adenosylhomocysteine deaminase activity
D0T88_RS04385	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS04390	COG1129	ABC transporter
D0T88_RS04395	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS04405	COG1064	alcohol dehydrogenase
D0T88_RS04420	COG1280	lysine exporter protein (LysE YggA)
D0T88_RS04430	COG3829	transcription factor binding
D0T88_RS04435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0T88_RS04440	COG0372	Belongs to the citrate synthase family
D0T88_RS04445	COG2079	MmgE PrpD family protein
D0T88_RS04450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0T88_RS04455	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS04460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0T88_RS04465	COG0402	S-adenosylhomocysteine deaminase activity
D0T88_RS04470	COG0583	DNA-binding transcription factor activity
D0T88_RS04475	COG0288	reversible hydration of carbon dioxide
D0T88_RS04485	COG2807	transmembrane transport
D0T88_RS04490	COG0110	maltose O-acetyltransferase activity
D0T88_RS04495	COG2223	nitrite transmembrane transporter activity
D0T88_RS04505	COG1609	Transcriptional regulator
D0T88_RS04510	COG1414	Transcriptional regulator
D0T88_RS04545	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS04550	COG2814	Major facilitator Superfamily
D0T88_RS04555	COG3122	Protein conserved in bacteria
D0T88_RS04585	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS04590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0T88_RS04595	COG4521	taurine ABC transporter
D0T88_RS04605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0T88_RS04610	COG2175	clavaminate synthase activity
D0T88_RS04615	COG0113	porphobilinogen synthase activity
D0T88_RS04620	COG3468	outer membrane autotransporter barrel domain protein
D0T88_RS04625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0T88_RS04630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0T88_RS04635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D0T88_RS04655	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0T88_RS04670	COG1785	Belongs to the alkaline phosphatase family
D0T88_RS04680	COG3706	GGDEF domain
D0T88_RS04685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0T88_RS04705	COG4126	flavin adenine dinucleotide binding
D0T88_RS04730	COG1940	carbohydrate kinase activity
D0T88_RS04735	COG2814	Major facilitator Superfamily
D0T88_RS04740	COG0419	ATPase involved in DNA repair
D0T88_RS04745	COG0420	3'-5' exonuclease activity
D0T88_RS04750	COG0745	RESPONSE REGULATOR receiver
D0T88_RS04755	COG5002	protein histidine kinase activity
D0T88_RS04760	COG1114	Component of the transport system for branched-chain amino acids
D0T88_RS04765	COG1113	amino acid transport
D0T88_RS04770	COG0366	Alpha amylase catalytic
D0T88_RS04790	COG1862	Preprotein translocase
D0T88_RS04795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0T88_RS04800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0T88_RS04805	COG1403	HNH endonuclease
D0T88_RS04810	COG3248	Nucleoside-binding outer membrane protein
D0T88_RS04815	COG4238	major outer membrane lipoprotein
D0T88_RS04825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0T88_RS04825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0T88_RS04840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D0T88_RS04845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0T88_RS04850	COG0667	Aldo Keto reductase
D0T88_RS04860	COG0142	geranyltranstransferase activity
D0T88_RS04875	COG0693	protein deglycase activity
D0T88_RS04880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0T88_RS04890	COG2814	Major facilitator Superfamily
D0T88_RS04900	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS04905	COG4372	Transposase
D0T88_RS04930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0T88_RS04935	COG1845	cytochrome c oxidase, subunit III
D0T88_RS04940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0T88_RS04945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0T88_RS04950	COG2223	nitrite transmembrane transporter activity
D0T88_RS04955	COG3056	Lipoprotein
D0T88_RS04960	COG0271	Belongs to the BolA IbaG family
D0T88_RS04980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0T88_RS04985	COG0776	regulation of translation
D0T88_RS04990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0T88_RS04995	COG1555	photosystem II stabilization
D0T88_RS05000	COG0824	Thioesterase
D0T88_RS05010	COG4533	DNA binding
D0T88_RS05020	COG1522	sequence-specific DNA binding
D0T88_RS05025	COG1132	(ABC) transporter
D0T88_RS05030	COG1132	(ABC) transporter
D0T88_RS05035	COG0347	Belongs to the P(II) protein family
D0T88_RS05040	COG0004	ammonium transporteR
D0T88_RS05045	COG1946	Acyl-CoA thioesterase
D0T88_RS05050	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D0T88_RS05055	COG3695	enzyme binding
D0T88_RS05065	COG5507	3-demethylubiquinone-9 3-methyltransferase
D0T88_RS05070	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0T88_RS05080	COG0110	maltose O-acetyltransferase activity
D0T88_RS05095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0T88_RS05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS05105	COG1309	transcriptional regulator
D0T88_RS05110	COG1196	nuclear chromosome segregation
D0T88_RS05110	COG3264	Mechanosensitive ion channel
D0T88_RS05120	COG3923	Primosomal replication protein n
D0T88_RS05125	COG2832	Protein of unknown function (DUF454)
D0T88_RS05135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0T88_RS05170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS05175	COG4651	solute:proton antiporter activity
D0T88_RS05175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0T88_RS05180	COG2223	nitrite transmembrane transporter activity
D0T88_RS05185	COG0737	Belongs to the 5'-nucleotidase family
D0T88_RS05190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0T88_RS05195	COG3735	TraB family
D0T88_RS05200	COG3093	addiction module antidote protein HigA
D0T88_RS05205	COG2217	Heavy metal translocating P-type atpase
D0T88_RS05210	COG2066	Belongs to the glutaminase family
D0T88_RS05215	COG0531	amino acid
D0T88_RS05220	COG0789	Transcriptional regulator
D0T88_RS05225	COG1585	Membrane protein implicated in regulation of membrane protease activity
D0T88_RS05230	COG0330	HflC and HflK could
D0T88_RS05235	COG4619	ABC transporter
D0T88_RS05240	COG0390	transport system, permease component
D0T88_RS05245	COG3118	belongs to the thioredoxin family
D0T88_RS05250	COG0300	oxidoreductase activity
D0T88_RS05255	COG2755	lipolytic protein G-D-S-L family
D0T88_RS05260	COG4181	ATPase activity
D0T88_RS05265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0T88_RS05270	COG3209	COG3209 Rhs family protein
D0T88_RS05275	COG3209	COG3209 Rhs family protein
D0T88_RS05295	COG0583	DNA-binding transcription factor activity
D0T88_RS05305	COG1414	Transcriptional regulator
D0T88_RS05310	COG3960	tartronate-semialdehyde synthase activity
D0T88_RS05315	COG3622	Belongs to the hyi family
D0T88_RS05320	COG2084	Dehydrogenase
D0T88_RS05325	COG1953	Uracil, thiamine, allantoin
D0T88_RS05335	COG2233	PERMEase
D0T88_RS05340	COG1929	Belongs to the glycerate kinase type-1 family
D0T88_RS05345	COG3257	ureidoglycine aminohydrolase activity
D0T88_RS05350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0T88_RS05355	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0T88_RS05360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0T88_RS05365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0T88_RS05375	COG0549	Belongs to the carbamate kinase family
D0T88_RS05380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0T88_RS05385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0T88_RS05395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0T88_RS05405	COG1988	membrane-bound metal-dependent
D0T88_RS05410	COG2501	S4 domain
D0T88_RS05420	COG3539	Fimbrial protein
D0T88_RS05425	COG3121	Chaperone
D0T88_RS05435	COG3539	Fimbrial protein
D0T88_RS05440	COG3539	Fimbrial protein
D0T88_RS05445	COG2197	response regulator
D0T88_RS05455	COG0582	viral genome integration into host DNA
D0T88_RS05510	COG0515	serine threonine protein kinase
D0T88_RS05510	COG2815	serine threonine protein kinase
D0T88_RS05545	COG2076	Multidrug Resistance protein
D0T88_RS05555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0T88_RS05560	COG1881	PFAM PEBP family protein
D0T88_RS05565	COG2207	Transcriptional regulator
D0T88_RS05615	COG3772	lysozyme
D0T88_RS05635	COG4220	transposase activity
D0T88_RS05655	COG1030	water channel activity
D0T88_RS05705	COG1196	nuclear chromosome segregation
D0T88_RS05740	COG5301	cellulose 1,4-beta-cellobiosidase activity
D0T88_RS05745	COG4372	Transposase
D0T88_RS05750	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS05760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0T88_RS05765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0T88_RS05780	COG0500	methyltransferase
D0T88_RS05790	COG2207	Transcriptional regulator
D0T88_RS05795	COG4571	Outer membrane protease
D0T88_RS05800	COG2207	Transcriptional regulator
D0T88_RS05810	COG4783	chaperone-mediated protein folding
D0T88_RS05815	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS05820	COG5433	transposase activity
D0T88_RS05850	COG4104	PAAR repeat-containing protein
D0T88_RS05850	COG3209	COG3209 Rhs family protein
D0T88_RS05855	COG3209	COG3209 Rhs family protein
D0T88_RS05855	COG4104	PAAR repeat-containing protein
D0T88_RS05865	COG3501	Rhs element vgr protein
D0T88_RS05870	COG5002	protein histidine kinase activity
D0T88_RS05875	COG0745	RESPONSE REGULATOR receiver
D0T88_RS05880	COG1538	Outer membrane efflux protein
D0T88_RS05885	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS05895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0T88_RS05900	COG1113	amino acid transport
D0T88_RS05905	COG0668	transmembrane transport
D0T88_RS05910	COG0778	Nitroreductase
D0T88_RS05915	COG2315	Protein conserved in bacteria
D0T88_RS05940	COG2977	Belongs to the P-Pant transferase superfamily
D0T88_RS05945	COG4771	TonB-dependent receptor
D0T88_RS05950	COG2382	esterase
D0T88_RS05955	COG3251	PFAM MbtH domain protein
D0T88_RS05960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0T88_RS05960	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D0T88_RS05965	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D0T88_RS05970	COG1120	ATPase activity
D0T88_RS05975	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0T88_RS05980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0T88_RS05990	COG4592	Periplasmic binding protein
D0T88_RS05995	COG1169	isochorismate synthase
D0T88_RS06000	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0T88_RS06005	COG3433	isochorismatase activity
D0T88_RS06005	COG1535	isochorismatase
D0T88_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS06015	COG2050	protein possibly involved in aromatic compounds catabolism
D0T88_RS06020	COG1966	Carbon starvation protein
D0T88_RS06025	COG2879	small protein
D0T88_RS06030	COG0371	Dehydrogenase
D0T88_RS06035	COG0436	Aminotransferase
D0T88_RS06040	COG1475	DNA binding
D0T88_RS06045	COG3969	phosphoadenosine phosphosulfate
D0T88_RS06050	COG0583	DNA-binding transcription factor activity
D0T88_RS06055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0T88_RS06060	COG0450	alkyl hydroperoxide reductase
D0T88_RS06065	COG3634	alkyl hydroperoxide reductase activity
D0T88_RS06070	COG0589	response to stress
D0T88_RS06075	COG1063	alcohol dehydrogenase
D0T88_RS06080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0T88_RS06085	COG3719	Belongs to the RNase T2 family
D0T88_RS06090	COG0471	metal ion transport
D0T88_RS06105	COG3051	citrate lyase alpha subunit
D0T88_RS06110	COG2301	Belongs to the HpcH HpaI aldolase family
D0T88_RS06120	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D0T88_RS06125	COG3290	protein histidine kinase activity
D0T88_RS06130	COG4565	transcriptional regulatory protein
D0T88_RS06135	COG3069	C4-dicarboxylate transmembrane transporter activity
D0T88_RS06155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0T88_RS06160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0T88_RS06170	COG0583	DNA-binding transcription factor activity
D0T88_RS06185	COG1686	Belongs to the peptidase S11 family
D0T88_RS06190	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0T88_RS06195	COG0772	Belongs to the SEDS family
D0T88_RS06200	COG0768	penicillin binding
D0T88_RS06210	COG0799	negative regulation of ribosome biogenesis
D0T88_RS06215	COG0406	alpha-ribazole phosphatase activity
D0T88_RS06225	COG1466	dna polymerase III delta subunit
D0T88_RS06240	COG2888	peptidyl-tyrosine sulfation
D0T88_RS06245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0T88_RS06255	COG2214	Heat shock protein DnaJ domain protein
D0T88_RS06260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0T88_RS06270	COG2214	Heat shock protein DnaJ domain protein
D0T88_RS06275	COG0443	Heat shock 70 kDa protein
D0T88_RS06285	COG1126	abc transporter atp-binding protein
D0T88_RS06290	COG0765	amino acid transport
D0T88_RS06295	COG0765	amino acid transport
D0T88_RS06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS06310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0T88_RS06315	COG4535	Mg2 and Co2 transporter CorC
D0T88_RS06325	COG1702	phosphate starvation-inducible protein PhoH
D0T88_RS06335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0T88_RS06375	COG0367	asparagine synthase
D0T88_RS06380	COG0647	UMP catabolic process
D0T88_RS06385	COG1940	carbohydrate kinase activity
D0T88_RS06385	COG1846	Transcriptional regulator
D0T88_RS06390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0T88_RS06400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS06400	COG1263	PTS System
D0T88_RS06400	COG2190	(PTS) system
D0T88_RS06420	COG0735	belongs to the Fur family
D0T88_RS06430	COG0716	FMN binding
D0T88_RS06440	COG0596	Alpha beta hydrolase
D0T88_RS06445	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D0T88_RS06450	COG0033	Phosphoglucomutase
D0T88_RS06455	COG0531	amino acid
D0T88_RS06460	COG1982	Orn Lys Arg decarboxylase major
D0T88_RS06470	COG0745	RESPONSE REGULATOR receiver
D0T88_RS06475	COG2205	protein histidine kinase activity
D0T88_RS06535	COG3272	Protein of unknown function (DUF1722)
D0T88_RS06540	COG0415	Belongs to the DNA photolyase family
D0T88_RS06550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0T88_RS06555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0T88_RS06560	COG1984	allophanate hydrolase subunit 2
D0T88_RS06575	COG3180	Ammonia monooxygenase
D0T88_RS06580	COG3539	Fimbrial protein
D0T88_RS06585	COG3121	Chaperone
D0T88_RS06590	COG3188	usher protein
D0T88_RS06595	COG3539	Fimbrial protein
D0T88_RS06600	COG0372	Belongs to the citrate synthase family
D0T88_RS06610	COG2009	succinate dehydrogenase
D0T88_RS06615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0T88_RS06620	COG1053	succinate dehydrogenase
D0T88_RS06625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0T88_RS06630	COG0567	Dehydrogenase, E1 component
D0T88_RS06635	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0T88_RS06645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0T88_RS06650	COG2188	Transcriptional regulator
D0T88_RS06655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS06655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS06655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS06660	COG0383	alpha-mannosidase activity
D0T88_RS06665	COG1271	oxidase subunit
D0T88_RS06670	COG1294	oxidase, subunit
D0T88_RS06675	COG4890	Cyd operon protein YbgT
D0T88_RS06680	COG3790	cyd operon protein YbgE
D0T88_RS06685	COG0824	Thioesterase
D0T88_RS06690	COG0811	peptide transport
D0T88_RS06695	COG0848	biopolymer transport protein
D0T88_RS06700	COG3064	Membrane
D0T88_RS06710	COG2885	chlorophyll binding
D0T88_RS06715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0T88_RS06765	COG3201	nicotinamide mononucleotide transporter
D0T88_RS06770	COG1230	cation diffusion facilitator family transporter
D0T88_RS06780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0T88_RS06790	COG2017	converts alpha-aldose to the beta-anomer
D0T88_RS06800	COG1085	galactose-1-phosphate uridylyltransferase
D0T88_RS06805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0T88_RS06810	COG1119	ATPase activity
D0T88_RS06815	COG3585	molybdate ion transport
D0T88_RS06815	COG2005	Transcriptional regulator
D0T88_RS06825	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0T88_RS06830	COG4149	molybdate abc transporter
D0T88_RS06840	COG0561	phosphatase activity
D0T88_RS06850	COG0583	DNA-binding transcription factor activity
D0T88_RS06855	COG2828	Protein conserved in bacteria
D0T88_RS06860	COG0471	metal ion transport
D0T88_RS06865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0T88_RS06870	COG4677	pectinesterase activity
D0T88_RS06875	COG1881	PFAM PEBP family protein
D0T88_RS06880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0T88_RS06895	COG2226	methyltransferase
D0T88_RS06900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0T88_RS06910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0T88_RS06920	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0T88_RS06930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0T88_RS06935	COG0314	molybdopterin synthase activity
D0T88_RS06940	COG0670	Belongs to the BI1 family
D0T88_RS06950	COG0670	Belongs to the BI1 family
D0T88_RS06955	COG0392	lysyltransferase activity
D0T88_RS06960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0T88_RS06965	COG3568	Endonuclease Exonuclease Phosphatase
D0T88_RS06975	COG0842	Transport permease protein
D0T88_RS06980	COG0842	Transport permease protein
D0T88_RS06985	COG1131	(ABC) transporter
D0T88_RS06995	COG1309	transcriptional regulator
D0T88_RS07000	COG0513	Belongs to the DEAD box helicase family
D0T88_RS07005	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS07010	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D0T88_RS07015	COG1199	ATP-dependent helicase activity
D0T88_RS07020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0T88_RS07025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0T88_RS07030	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS07040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0T88_RS07050	COG4774	siderophore transport
D0T88_RS07065	COG0668	transmembrane transport
D0T88_RS07070	COG1126	abc transporter atp-binding protein
D0T88_RS07075	COG0765	amino acid transport
D0T88_RS07080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS07090	COG5006	permease, DMT superfamily
D0T88_RS07100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0T88_RS07105	COG2194	sulfuric ester hydrolase activity
D0T88_RS07115	COG1321	iron dependent repressor
D0T88_RS07120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0T88_RS07125	COG1376	ErfK ybiS ycfS ynhG family protein
D0T88_RS07130	COG0488	(ABC) transporter
D0T88_RS07135	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS07145	COG0561	phosphatase activity
D0T88_RS07150	COG1882	Formate acetyltransferase
D0T88_RS07155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0T88_RS07160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0T88_RS07165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0T88_RS07170	COG0303	'Molybdopterin
D0T88_RS07175	COG1446	asparaginase
D0T88_RS07200	COG2200	EAL domain
D0T88_RS07205	COG2199	diguanylate cyclase activity
D0T88_RS07220	COG2133	pyrroloquinoline quinone binding
D0T88_RS07225	COG0625	glutathione transferase activity
D0T88_RS07230	COG1686	Belongs to the peptidase S11 family
D0T88_RS07235	COG1349	DNA-binding transcription factor activity
D0T88_RS07240	COG0671	phosphoesterase, PA-phosphatase related
D0T88_RS07245	COG2814	Major facilitator Superfamily
D0T88_RS07255	COG0561	phosphatase activity
D0T88_RS07260	COG0738	Major facilitator superfamily
D0T88_RS07265	COG3226	Transcriptional regulator
D0T88_RS07280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0T88_RS07290	COG0778	Nitroreductase
D0T88_RS07305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0T88_RS07310	COG3842	ATPase activity
D0T88_RS07315	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0T88_RS07320	COG1177	transmembrane transport
D0T88_RS07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS07340	COG4160	amino acid transport
D0T88_RS07345	COG4215	(ABC) transporter
D0T88_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS07355	COG1126	abc transporter atp-binding protein
D0T88_RS07370	COG3023	N-Acetylmuramoyl-L-alanine amidase
D0T88_RS07375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0T88_RS07380	COG0702	epimerase
D0T88_RS07385	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0T88_RS07390	COG0028	Belongs to the TPP enzyme family
D0T88_RS07395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0T88_RS07405	COG2431	L-lysine efflux transmembrane transporter activity
D0T88_RS07415	COG3593	DNA synthesis involved in DNA repair
D0T88_RS07420	COG2990	Protein conserved in bacteria
D0T88_RS07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS07435	COG1278	Cold shock
D0T88_RS07445	COG0542	response to heat
D0T88_RS07465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0T88_RS07470	COG4988	ABC transporter
D0T88_RS07475	COG0492	ferredoxin-NADP+ reductase activity
D0T88_RS07480	COG1522	sequence-specific DNA binding
D0T88_RS07495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0T88_RS07505	COG0243	molybdopterin cofactor binding
D0T88_RS07510	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS07515	COG3302	dmso reductase anchor subunit
D0T88_RS07520	COG1335	isochorismatase
D0T88_RS07530	COG0531	amino acid
D0T88_RS07535	COG0583	DNA-binding transcription factor activity
D0T88_RS07540	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0T88_RS07545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0T88_RS07550	COG1882	Formate acetyltransferase
D0T88_RS07555	COG2116	formate transmembrane transporter activity
D0T88_RS07560	COG1944	ATP diphosphatase activity
D0T88_RS07565	COG2323	membrane
D0T88_RS07580	COG0501	Belongs to the peptidase M48B family
D0T88_RS07590	COG0539	negative regulation of cytoplasmic translation
D0T88_RS07600	COG0658	competence protein
D0T88_RS07600	COG2333	competence protein COMEC
D0T88_RS07605	COG1132	(ABC) transporter
D0T88_RS07615	COG3214	Protein conserved in bacteria
D0T88_RS07630	COG3173	Aminoglycoside phosphotransferase
D0T88_RS07635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0T88_RS07640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0T88_RS07650	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D0T88_RS07660	COG2989	Protein conserved in bacteria
D0T88_RS07665	COG3108	Peptidase M15
D0T88_RS07670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0T88_RS07675	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS07680	COG1448	Aminotransferase
D0T88_RS07700	COG0308	aminopeptidase N
D0T88_RS07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0T88_RS07720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0T88_RS07725	COG0431	NADPH-dependent FMN reductase
D0T88_RS07730	COG3539	Fimbrial protein
D0T88_RS07735	COG3121	Chaperone
D0T88_RS07740	COG3188	usher protein
D0T88_RS07745	COG3539	Fimbrial protein
D0T88_RS07750	COG3539	Fimbrial protein
D0T88_RS07755	COG3539	Fimbrial protein
D0T88_RS07760	COG3121	Chaperone
D0T88_RS07775	COG3217	Mosc domain protein beta barrel domain protein
D0T88_RS07775	COG0633	Ferredoxin
D0T88_RS07785	COG0488	(ABC) transporter
D0T88_RS07790	COG2995	paraquat-inducible protein a
D0T88_RS07795	COG3008	intermembrane lipid transfer
D0T88_RS07795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0T88_RS07800	COG3009	Protein conserved in bacteria
D0T88_RS07805	COG3130	regulation of translation
D0T88_RS07815	COG1067	ATP-dependent peptidase activity
D0T88_RS07835	COG3070	regulator of competence-specific genes
D0T88_RS07840	COG1289	transmembrane transporter activity
D0T88_RS07845	COG3304	Inner membrane component domain
D0T88_RS07850	COG0210	DNA helicase
D0T88_RS07865	COG1832	CoA-binding protein
D0T88_RS07880	COG1254	Belongs to the acylphosphatase family
D0T88_RS07885	COG2920	part of a sulfur-relay system
D0T88_RS07890	COG0670	Belongs to the BI1 family
D0T88_RS07900	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D0T88_RS07905	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D0T88_RS07910	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
D0T88_RS07915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D0T88_RS07920	COG1999	signal sequence binding
D0T88_RS07925	COG1773	rubredoxin
D0T88_RS07930	COG1271	oxidase subunit
D0T88_RS07935	COG1294	oxidase, subunit
D0T88_RS07950	COG0489	protein tyrosine kinase activity
D0T88_RS07950	COG3206	protein involved in exopolysaccharide biosynthesis
D0T88_RS07955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0T88_RS07960	COG1596	polysaccharide export
D0T88_RS07965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0T88_RS07985	COG1278	Cold shock
D0T88_RS07990	COG1278	Cold shock
D0T88_RS08010	COG0348	domain, Protein
D0T88_RS08015	COG2198	Histidine kinase
D0T88_RS08015	COG0784	Response regulator, receiver
D0T88_RS08015	COG2205	protein histidine kinase activity
D0T88_RS08020	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS08025	COG0745	RESPONSE REGULATOR receiver
D0T88_RS08030	COG3005	denitrification pathway
D0T88_RS08035	COG0243	molybdopterin cofactor binding
D0T88_RS08075	COG3729	General stress protein
D0T88_RS08080	COG2233	PERMEase
D0T88_RS08115	COG1309	transcriptional regulator
D0T88_RS08120	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0T88_RS08120	COG0506	proline dehydrogenase activity
D0T88_RS08120	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0T88_RS08130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0T88_RS08140	COG2822	iron ion transport
D0T88_RS08150	COG1702	phosphate starvation-inducible protein PhoH
D0T88_RS08155	COG3658	cytochrome
D0T88_RS08160	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS08165	COG1649	PFAM Uncharacterised BCR, COG1649
D0T88_RS08165	COG0726	polysaccharide deacetylase
D0T88_RS08170	COG0457	Tetratricopeptide repeat
D0T88_RS08175	COG3706	GGDEF domain
D0T88_RS08210	COG3381	protein complex oligomerization
D0T88_RS08220	COG1462	curli production assembly transport component CsgG
D0T88_RS08235	COG2197	response regulator
D0T88_RS08260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0T88_RS08265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0T88_RS08280	COG2943	transferase activity, transferring hexosyl groups
D0T88_RS08285	COG5645	(Lipo)protein
D0T88_RS08300	COG1560	Kdo2-lipid A biosynthetic process
D0T88_RS08310	COG2353	YceI-like domain
D0T88_RS08315	COG3038	cytochrome b561
D0T88_RS08350	COG2999	glutathione oxidoreductase activity
D0T88_RS08360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0T88_RS08370	COG0673	inositol 2-dehydrogenase activity
D0T88_RS08375	COG0728	peptidoglycan biosynthetic process
D0T88_RS08380	COG3418	PFAM FlgN family protein
D0T88_RS08385	COG2747	anti-sigma28 factor FlgM
D0T88_RS08390	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D0T88_RS08395	COG1815	bacterial-type flagellum-dependent cell motility
D0T88_RS08400	COG1558	bacterial-type flagellum-dependent cell motility
D0T88_RS08405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0T88_RS08410	COG1749	Flagellar hook protein flgE
D0T88_RS08415	COG4787	bacterial-type flagellum-dependent cell motility
D0T88_RS08420	COG4786	Flagellar basal body rod
D0T88_RS08435	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0T88_RS08435	COG3951	Flagellar rod assembly protein muramidase FlgJ
D0T88_RS08440	COG1256	bacterial-type flagellum assembly
D0T88_RS08445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0T88_RS08450	COG1530	ribonuclease E activity
D0T88_RS08455	COG0564	pseudouridine synthase activity
D0T88_RS08460	COG0424	maF-like protein
D0T88_RS08465	COG1399	metal-binding, possibly nucleic acid-binding protein
D0T88_RS08485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0T88_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS08500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0T88_RS08505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0T88_RS08510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0T88_RS08520	COG0470	DNA polymerase III
D0T88_RS08525	COG0084	hydrolase, TatD family'
D0T88_RS08530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS08530	COG1263	PTS System
D0T88_RS08535	COG4773	Receptor
D0T88_RS08540	COG0537	adenosine 5'-monophosphoramidase activity
D0T88_RS08545	COG5633	Lipoprotein
D0T88_RS08550	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D0T88_RS08570	COG1252	NADH dehydrogenase
D0T88_RS08575	COG3134	Outer membrane lipoprotein
D0T88_RS08580	COG1309	transcriptional regulator
D0T88_RS08590	COG1388	LysM domain
D0T88_RS08590	COG1376	ErfK ybiS ycfS ynhG family protein
D0T88_RS08595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0T88_RS08600	COG4763	Acyl-transferase
D0T88_RS08605	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0T88_RS08610	COG1136	(ABC) transporter
D0T88_RS08615	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0T88_RS08625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0T88_RS08630	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D0T88_RS08640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0T88_RS08645	COG1177	transmembrane transport
D0T88_RS08660	COG0582	viral genome integration into host DNA
D0T88_RS08670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0T88_RS08725	COG1484	DNA-dependent DNA replication
D0T88_RS08750	COG4372	Transposase
D0T88_RS08755	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS08785	COG1403	HNH endonuclease
D0T88_RS08790	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
D0T88_RS08870	COG4220	transposase activity
D0T88_RS08975	COG5301	cellulose 1,4-beta-cellobiosidase activity
D0T88_RS08980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0T88_RS08990	COG3842	ATPase activity
D0T88_RS09000	COG2850	peptidyl-arginine hydroxylation
D0T88_RS09005	COG2205	protein histidine kinase activity
D0T88_RS09015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0T88_RS09035	COG1187	pseudouridine synthase activity
D0T88_RS09040	COG0538	isocitrate dehydrogenase activity
D0T88_RS09060	COG5562	phage envelope protein
D0T88_RS09065	COG0789	Transcriptional regulator
D0T88_RS09070	COG2200	EAL domain
D0T88_RS09095	COG2200	EAL domain
D0T88_RS09150	COG2894	cell division
D0T88_RS09175	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0T88_RS09190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0T88_RS09195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0T88_RS09200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0T88_RS09215	COG2719	SpoVR family
D0T88_RS09225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0T88_RS09235	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0T88_RS09245	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D0T88_RS09265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0T88_RS09265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS09265	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D0T88_RS09270	COG1461	Dihydroxyacetone kinase
D0T88_RS09275	COG2376	Dihydroxyacetone kinase
D0T88_RS09280	COG3284	Transcriptional regulator
D0T88_RS09285	COG3468	outer membrane autotransporter barrel domain protein
D0T88_RS09290	COG0012	GTP binding
D0T88_RS09305	COG0659	secondary active sulfate transmembrane transporter activity
D0T88_RS09310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0T88_RS09335	COG2890	protein-(glutamine-N5) methyltransferase activity
D0T88_RS09340	COG3094	Invasion gene expression up-regulator, SirB
D0T88_RS09345	COG2912	Transglutaminase-like superfamily
D0T88_RS09370	COG0387	Pfam Sodium calcium exchanger
D0T88_RS09375	COG4572	Cation transport regulator
D0T88_RS09380	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D0T88_RS09385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D0T88_RS09390	COG4932	domain protein
D0T88_RS09395	COG2197	response regulator
D0T88_RS09400	COG3850	Histidine kinase
D0T88_RS09405	COG2223	nitrite transmembrane transporter activity
D0T88_RS09410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D0T88_RS09415	COG1140	nitrate reductase beta subunit
D0T88_RS09420	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D0T88_RS09425	COG2181	nitrate reductase activity
D0T88_RS09450	COG0788	formyltetrahydrofolate deformylase activity
D0T88_RS09460	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0T88_RS09465	COG0745	RESPONSE REGULATOR receiver
D0T88_RS09470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0T88_RS09480	COG1435	thymidine kinase activity
D0T88_RS09485	COG1454	alcohol dehydrogenase
D0T88_RS09485	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS09490	COG2095	MarC family integral membrane protein
D0T88_RS09500	COG4166	transmembrane transport
D0T88_RS09505	COG0601	transmembrane transport
D0T88_RS09510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0T88_RS09515	COG0444	Belongs to the ABC transporter superfamily
D0T88_RS09520	COG4608	Belongs to the ABC transporter superfamily
D0T88_RS09540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0T88_RS09545	COG2350	Protein conserved in bacteria
D0T88_RS09550	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D0T88_RS09555	COG1607	acyl-coa hydrolase
D0T88_RS09575	COG3047	cAMP biosynthetic process
D0T88_RS09580	COG3685	Protein conserved in bacteria
D0T88_RS09585	COG3685	Protein conserved in bacteria
D0T88_RS09590	COG3729	General stress protein
D0T88_RS09605	COG0134	indole-3-glycerol-phosphate synthase activity
D0T88_RS09605	COG0135	phosphoribosylanthranilate isomerase activity
D0T88_RS09610	COG0512	Glutamine amidotransferase of anthranilate synthase
D0T88_RS09610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0T88_RS09615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0T88_RS09625	COG0613	PHP domain protein
D0T88_RS09630	COG0009	L-threonylcarbamoyladenylate synthase
D0T88_RS09635	COG1187	pseudouridine synthase activity
D0T88_RS09640	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D0T88_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS09650	COG0616	signal peptide processing
D0T88_RS09660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0T88_RS09665	COG0583	DNA-binding transcription factor activity
D0T88_RS09685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0T88_RS09695	COG0671	phosphoesterase, PA-phosphatase related
D0T88_RS09700	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0T88_RS09705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0T88_RS09715	COG0023	Translation Initiation Factor
D0T88_RS09725	COG1349	DNA-binding transcription factor activity
D0T88_RS09735	COG5001	Diguanylate cyclase
D0T88_RS09750	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0T88_RS09750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0T88_RS09755	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0T88_RS09760	COG2852	Protein conserved in bacteria
D0T88_RS09765	COG4172	Belongs to the ABC transporter superfamily
D0T88_RS09770	COG4172	Belongs to the ABC transporter superfamily
D0T88_RS09775	COG4171	peptide transport system, permease
D0T88_RS09780	COG4168	peptide transport system, permease
D0T88_RS09785	COG4166	transmembrane transport
D0T88_RS09795	COG0531	amino acid
D0T88_RS09805	COG0174	glutamine synthetase
D0T88_RS09810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0T88_RS09815	COG1917	Cupin 2, conserved barrel domain protein
D0T88_RS09815	COG1396	sequence-specific DNA binding
D0T88_RS09820	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS09825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0T88_RS09830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0T88_RS09835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0T88_RS09840	COG1842	Phage shock protein A
D0T88_RS09850	COG1983	PspC domain protein
D0T88_RS09860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0T88_RS09865	COG0366	Alpha amylase catalytic
D0T88_RS09870	COG1653	transport
D0T88_RS09875	COG1175	transmembrane transport
D0T88_RS09880	COG0395	ABC-type sugar transport system, permease component
D0T88_RS09885	COG1063	alcohol dehydrogenase
D0T88_RS09890	COG1082	Xylose isomerase domain protein TIM barrel
D0T88_RS09895	COG0673	inositol 2-dehydrogenase activity
D0T88_RS09900	COG1554	hydrolase, family 65, central catalytic
D0T88_RS09905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0T88_RS09910	COG3842	ATPase activity
D0T88_RS09920	COG1609	Transcriptional regulator
D0T88_RS09925	COG3106	COG3106 Predicted ATPase
D0T88_RS09935	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D0T88_RS09940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D0T88_RS09945	COG4948	Mandelate Racemase Muconate Lactonizing
D0T88_RS09950	COG2866	Carboxypeptidase
D0T88_RS09965	COG1073	alpha beta
D0T88_RS09970	COG0583	DNA-binding transcription factor activity
D0T88_RS09975	COG4166	transmembrane transport
D0T88_RS09980	COG0668	transmembrane transport
D0T88_RS09985	COG3182	Iron-regulated membrane protein
D0T88_RS09990	COG0589	response to stress
D0T88_RS09995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0T88_RS10000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0T88_RS10005	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0T88_RS10010	COG1473	amidohydrolase
D0T88_RS10015	COG1473	amidohydrolase
D0T88_RS10020	COG0583	DNA-binding transcription factor activity
D0T88_RS10025	COG2840	Smr protein MutS2
D0T88_RS10030	COG3706	GGDEF domain
D0T88_RS10040	COG0513	Belongs to the DEAD box helicase family
D0T88_RS10050	COG0589	response to stress
D0T88_RS10055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0T88_RS10060	COG0674	pyruvate-flavodoxin oxidoreductase activity
D0T88_RS10060	COG1013	pyruvate-flavodoxin oxidoreductase activity
D0T88_RS10060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D0T88_RS10060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0T88_RS10065	COG3042	response to heat
D0T88_RS10070	COG3187	Heat shock protein
D0T88_RS10075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0T88_RS10080	COG2911	Protein conserved in bacteria
D0T88_RS10090	COG3784	Protein of unknown function (DUF1318)
D0T88_RS10095	COG2207	Transcriptional regulator
D0T88_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS10105	COG3733	amine oxidase
D0T88_RS10110	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS10110	COG2030	dehydratase
D0T88_RS10115	COG3396	Phenylacetate-CoA oxygenase
D0T88_RS10120	COG3460	Phenylacetate-CoA oxygenase
D0T88_RS10125	COG3396	Phenylacetate-CoA oxygenase
D0T88_RS10130	COG2151	metal-sulfur cluster biosynthetic enzyme
D0T88_RS10135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0T88_RS10140	COG1024	Enoyl-CoA hydratase
D0T88_RS10145	COG1024	Enoyl-CoA hydratase
D0T88_RS10150	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0T88_RS10155	COG2050	protein possibly involved in aromatic compounds catabolism
D0T88_RS10160	COG0183	Belongs to the thiolase family
D0T88_RS10165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D0T88_RS10170	COG3327	negative regulation of DNA-templated transcription, initiation
D0T88_RS10175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0T88_RS10180	COG0667	Aldo Keto reductase
D0T88_RS10190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0T88_RS10195	COG4589	Belongs to the CDS family
D0T88_RS10200	COG2267	carboxylic ester hydrolase activity
D0T88_RS10205	COG0671	phosphoesterase, PA-phosphatase related
D0T88_RS10205	COG2453	phosphatase
D0T88_RS10215	COG1643	Atp-dependent helicase
D0T88_RS10220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0T88_RS10225	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS10230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0T88_RS10235	COG3038	cytochrome b561
D0T88_RS10250	COG0840	transmembrane signaling receptor activity
D0T88_RS10255	COG0583	DNA-binding transcription factor activity
D0T88_RS10260	COG5383	Protein conserved in bacteria
D0T88_RS10270	COG2841	Protein conserved in bacteria
D0T88_RS10275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0T88_RS10280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0T88_RS10285	COG1275	C4-dicarboxylate transporter malic acid transport protein
D0T88_RS10290	COG0500	methyltransferase
D0T88_RS10305	COG0675	Transposase, IS605 OrfB family
D0T88_RS10310	COG3135	benzoate transporter
D0T88_RS10315	COG1396	sequence-specific DNA binding
D0T88_RS10320	COG0826	peptidase U32
D0T88_RS10330	COG1724	mRNA binding
D0T88_RS10335	COG1598	PFAM Uncharacterised protein family UPF0150
D0T88_RS10340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0T88_RS10345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0T88_RS10355	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0T88_RS10360	COG1177	transmembrane transport
D0T88_RS10385	COG3238	Protein conserved in bacteria
D0T88_RS10390	COG1247	-acetyltransferase
D0T88_RS10395	COG2130	NADP-dependent
D0T88_RS10400	COG1802	Transcriptional regulator
D0T88_RS10405	COG4772	TonB-dependent receptor
D0T88_RS10410	COG3391	amine dehydrogenase activity
D0T88_RS10415	COG1113	amino acid transport
D0T88_RS10420	COG0625	glutathione transferase activity
D0T88_RS10435	COG3209	COG3209 Rhs family protein
D0T88_RS10465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0T88_RS10470	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0T88_RS10475	COG0384	phenazine biosynthesis protein PhzF
D0T88_RS10480	COG2181	nitrate reductase activity
D0T88_RS10485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D0T88_RS10490	COG1140	nitrate reductase beta subunit
D0T88_RS10495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D0T88_RS10500	COG2223	nitrite transmembrane transporter activity
D0T88_RS10505	COG4886	Leucine-rich repeat (LRR) protein
D0T88_RS10510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0T88_RS10515	COG0697	spore germination
D0T88_RS10525	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS10530	COG2864	formate dehydrogenase
D0T88_RS10535	COG3093	addiction module antidote protein HigA
D0T88_RS10540	COG1064	alcohol dehydrogenase
D0T88_RS10560	COG1764	response to oxidative stress
D0T88_RS10565	COG4608	Belongs to the ABC transporter superfamily
D0T88_RS10570	COG0444	Belongs to the ABC transporter superfamily
D0T88_RS10575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0T88_RS10580	COG0601	transmembrane transport
D0T88_RS10585	COG0747	negative chemotaxis
D0T88_RS10590	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D0T88_RS10610	COG1649	PFAM Uncharacterised BCR, COG1649
D0T88_RS10615	COG0531	amino acid
D0T88_RS10620	COG0076	glutamate decarboxylase activity
D0T88_RS10625	COG0612	Peptidase, M16
D0T88_RS10630	COG4771	TonB-dependent receptor
D0T88_RS10635	COG4178	(ABC) transporter
D0T88_RS10645	COG0641	radical SAM
D0T88_RS10650	COG3119	arylsulfatase activity
D0T88_RS10655	COG2207	Transcriptional regulator
D0T88_RS10665	COG0243	molybdopterin cofactor binding
D0T88_RS10670	COG3539	Fimbrial protein
D0T88_RS10675	COG3539	Fimbrial protein
D0T88_RS10680	COG3539	Fimbrial protein
D0T88_RS10690	COG4372	Transposase
D0T88_RS10695	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS10710	COG3539	Fimbrial protein
D0T88_RS10715	COG3550	peptidyl-serine autophosphorylation
D0T88_RS10720	COG1396	sequence-specific DNA binding
D0T88_RS10725	COG2911	Protein conserved in bacteria
D0T88_RS10725	COG3210	domain, Protein
D0T88_RS10775	COG3781	membrane
D0T88_RS10785	COG2199	diguanylate cyclase activity
D0T88_RS10795	COG2066	Belongs to the glutaminase family
D0T88_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS10805	COG0583	DNA-binding transcription factor activity
D0T88_RS10825	COG1846	Transcriptional regulator
D0T88_RS10830	COG4977	sequence-specific DNA binding
D0T88_RS10850	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0T88_RS10855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0T88_RS10865	COG2188	Transcriptional regulator
D0T88_RS10870	COG0697	spore germination
D0T88_RS10885	COG3706	GGDEF domain
D0T88_RS10890	COG3111	PFAM Bacterial OB fold (BOF) protein
D0T88_RS10895	COG1546	Belongs to the CinA family
D0T88_RS10900	COG0339	signal peptide processing
D0T88_RS10905	COG4221	oxidoreductase activity
D0T88_RS10910	COG1802	Transcriptional regulator
D0T88_RS10920	COG0246	Mannitol dehydrogenase
D0T88_RS10935	COG1121	(ABC) transporter
D0T88_RS10940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0T88_RS10945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0T88_RS11005	COG1196	nuclear chromosome segregation
D0T88_RS11075	COG4220	transposase activity
D0T88_RS11090	COG3772	lysozyme
D0T88_RS11130	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
D0T88_RS11135	COG1403	HNH endonuclease
D0T88_RS11165	COG4372	Transposase
D0T88_RS11170	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS11180	COG1846	Transcriptional regulator
D0T88_RS11195	COG1396	sequence-specific DNA binding
D0T88_RS11225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0T88_RS11235	COG0582	viral genome integration into host DNA
D0T88_RS11245	COG1063	alcohol dehydrogenase
D0T88_RS11250	COG4948	Mandelate Racemase Muconate Lactonizing
D0T88_RS11265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0T88_RS11280	COG0243	molybdopterin cofactor binding
D0T88_RS11285	COG0243	molybdopterin cofactor binding
D0T88_RS11290	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS11295	COG3302	dmso reductase anchor subunit
D0T88_RS11300	COG3381	protein complex oligomerization
D0T88_RS11310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0T88_RS11315	COG1940	carbohydrate kinase activity
D0T88_RS11320	COG0583	DNA-binding transcription factor activity
D0T88_RS11340	COG3591	Belongs to the peptidase S1B family
D0T88_RS11355	COG0628	permease
D0T88_RS11360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0T88_RS11365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0T88_RS11375	COG0531	amino acid
D0T88_RS11385	COG3136	membrane protein required for alginate biosynthesis
D0T88_RS11390	COG0745	RESPONSE REGULATOR receiver
D0T88_RS11395	COG2205	protein histidine kinase activity
D0T88_RS11405	COG0114	fumarate hydratase activity
D0T88_RS11410	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0T88_RS11410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0T88_RS11415	COG1482	cell wall glycoprotein biosynthetic process
D0T88_RS11420	COG5339	Protein conserved in bacteria
D0T88_RS11435	COG3250	beta-galactosidase activity
D0T88_RS11440	COG1309	transcriptional regulator
D0T88_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS11450	COG1609	Transcriptional regulator
D0T88_RS11455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS11455	COG1263	PTS System
D0T88_RS11460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0T88_RS11470	COG0673	inositol 2-dehydrogenase activity
D0T88_RS11510	COG4659	FMN binding
D0T88_RS11520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0T88_RS11525	COG3104	oligopeptide transport
D0T88_RS11530	COG0625	glutathione transferase activity
D0T88_RS11535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0T88_RS11550	COG3895	Periplasmic Protein
D0T88_RS11560	COG3133	Outer membrane lipoprotein
D0T88_RS11575	COG1566	PFAM secretion protein HlyD family protein
D0T88_RS11585	COG2032	superoxide dismutase activity
D0T88_RS11590	COG4989	oxidoreductase activity
D0T88_RS11595	COG3313	Fe-S protein
D0T88_RS11600	COG1309	transcriptional regulator
D0T88_RS11605	COG1902	pentaerythritol trinitrate reductase activity
D0T88_RS11610	COG0346	lactoylglutathione lyase activity
D0T88_RS11620	COG1201	RNA secondary structure unwinding
D0T88_RS11625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0T88_RS11630	COG0791	NLP P60 protein
D0T88_RS11635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0T88_RS11640	COG2814	Major facilitator Superfamily
D0T88_RS11655	COG0583	DNA-binding transcription factor activity
D0T88_RS11660	COG2814	Major facilitator Superfamily
D0T88_RS11665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0T88_RS11670	COG0307	riboflavin synthase, alpha
D0T88_RS11680	COG3468	outer membrane autotransporter barrel domain protein
D0T88_RS11700	COG4529	Protein conserved in bacteria
D0T88_RS11710	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D0T88_RS11715	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS11725	COG2414	aldehyde ferredoxin oxidoreductase
D0T88_RS11730	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS11740	COG0469	pyruvate kinase activity
D0T88_RS11745	COG4238	major outer membrane lipoprotein
D0T88_RS11750	COG1376	ErfK ybiS ycfS ynhG family protein
D0T88_RS11765	COG0719	Fe-S assembly protein
D0T88_RS11770	COG0396	ATPase activity
D0T88_RS11775	COG0719	Fe-S assembly protein
D0T88_RS11780	COG0316	Belongs to the HesB IscA family
D0T88_RS11790	COG2050	protein possibly involved in aromatic compounds catabolism
D0T88_RS11795	COG0277	FAD linked oxidase domain protein
D0T88_RS11795	COG0247	lactate metabolic process
D0T88_RS11800	COG0628	permease
D0T88_RS11815	COG0738	Major facilitator superfamily
D0T88_RS11820	COG2271	Major facilitator Superfamily
D0T88_RS11835	COG4670	ketone body catabolic process
D0T88_RS11840	COG1960	acyl-CoA dehydrogenase activity
D0T88_RS11845	COG1917	Cupin 2, conserved barrel domain protein
D0T88_RS11845	COG2207	Transcriptional regulator
D0T88_RS11850	COG2086	electron transfer activity
D0T88_RS11855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D0T88_RS11860	COG0644	oxidoreductase
D0T88_RS11865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D0T88_RS11870	COG0318	PFAM AMP-dependent synthetase and ligase
D0T88_RS11875	COG0574	Belongs to the PEP-utilizing enzyme family
D0T88_RS11875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0T88_RS11885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0T88_RS11890	COG4256	Hemin uptake protein
D0T88_RS11900	COG2200	EAL domain
D0T88_RS11905	COG0791	NLP P60 protein
D0T88_RS11915	COG0386	Belongs to the glutathione peroxidase family
D0T88_RS11975	COG3137	Salt-induced outer membrane protein
D0T88_RS11980	COG1105	Belongs to the carbohydrate kinase PfkB family
D0T88_RS11990	COG3001	Fructosamine kinase
D0T88_RS12000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0T88_RS12005	COG1988	membrane-bound metal-dependent
D0T88_RS12010	COG1823	symporter activity
D0T88_RS12030	COG0753	catalase activity
D0T88_RS12040	COG1486	melibiose metabolic process
D0T88_RS12045	COG2169	Transcriptional regulator
D0T88_RS12045	COG1917	Cupin 2, conserved barrel domain protein
D0T88_RS12050	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0T88_RS12055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0T88_RS12060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0T88_RS12065	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0T88_RS12075	COG0322	excinuclease ABC activity
D0T88_RS12085	COG3678	ATP-independent chaperone mediated protein folding
D0T88_RS12115	COG0708	Exodeoxyribonuclease III
D0T88_RS12120	COG0398	Pfam SNARE associated Golgi protein
D0T88_RS12130	COG0398	Pfam SNARE associated Golgi protein
D0T88_RS12135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0T88_RS12140	COG4134	Bacterial extracellular solute-binding protein
D0T88_RS12145	COG4135	transport system, permease component
D0T88_RS12150	COG4136	ATPase activity
D0T88_RS12155	COG2897	thiosulfate sulfurtransferase activity
D0T88_RS12160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0T88_RS12165	COG0494	nUDIX hydrolase
D0T88_RS12175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0T88_RS12185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0T88_RS12195	COG0778	Nitroreductase
D0T88_RS12200	COG0616	signal peptide processing
D0T88_RS12205	COG0252	asparaginase activity
D0T88_RS12215	COG3139	Protein of unknown function (DUF1315)
D0T88_RS12225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0T88_RS12230	COG0676	glucose-6-phosphate 1-epimerase activity
D0T88_RS12235	COG0656	L-ascorbic acid biosynthetic process
D0T88_RS12240	COG3713	MltA-interacting MipA family protein
D0T88_RS12245	COG2766	serine protein kinase
D0T88_RS12255	COG2199	diguanylate cyclase activity
D0T88_RS12260	COG2199	diguanylate cyclase activity
D0T88_RS12265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0T88_RS12280	COG2207	Transcriptional regulator
D0T88_RS12285	COG2807	transmembrane transport
D0T88_RS12290	COG3189	MarR family transcriptional regulator
D0T88_RS12295	COG3042	response to heat
D0T88_RS12300	COG2199	diguanylate cyclase activity
D0T88_RS12300	COG2203	Gaf domain
D0T88_RS12315	COG2261	transglycosylase associated protein
D0T88_RS12320	COG0675	Transposase, IS605 OrfB family
D0T88_RS12335	COG3615	Tellurite resistance protein tehB
D0T88_RS12345	COG0583	DNA-binding transcription factor activity
D0T88_RS12350	COG0473	3-isopropylmalate dehydrogenase activity
D0T88_RS12355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0T88_RS12360	COG4638	Rieske (2fe-2S)
D0T88_RS12365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0T88_RS12370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0T88_RS12375	COG0318	PFAM AMP-dependent synthetase and ligase
D0T88_RS12380	COG3065	identical protein binding
D0T88_RS12385	COG1214	PFAM Peptidase M22, glycoprotease
D0T88_RS12390	COG1199	ATP-dependent helicase activity
D0T88_RS12395	COG0251	oxidation-reduction process
D0T88_RS12410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0T88_RS12420	COG1760	l-serine dehydratase
D0T88_RS12425	COG2200	EAL domain
D0T88_RS12430	COG1253	flavin adenine dinucleotide binding
D0T88_RS12435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS12435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS12440	COG3715	PTS system
D0T88_RS12445	COG3716	PTS system mannose fructose sorbose family IID component
D0T88_RS12460	COG2226	methyltransferase
D0T88_RS12490	COG1414	Transcriptional regulator
D0T88_RS12495	COG2814	Major facilitator Superfamily
D0T88_RS12505	COG0793	Belongs to the peptidase S41A family
D0T88_RS12515	COG1956	GAF domain-containing protein
D0T88_RS12520	COG2995	paraquat-inducible protein a
D0T88_RS12525	COG3008	intermembrane lipid transfer
D0T88_RS12545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0T88_RS12685	COG1783	phage Terminase large subunit
D0T88_RS12690	COG3728	DNA packaging
D0T88_RS12690	COG5484	DNA packaging
D0T88_RS12770	COG1846	Transcriptional regulator
D0T88_RS12775	COG1484	DNA-dependent DNA replication
D0T88_RS12780	COG3756	Protein conserved in bacteria
D0T88_RS12790	COG4197	protein conserved in bacteria, prophage-related
D0T88_RS12820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0T88_RS12855	COG0582	viral genome integration into host DNA
D0T88_RS12865	COG1276	copper resistance
D0T88_RS12870	COG2372	response to copper ion
D0T88_RS12880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0T88_RS12885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0T88_RS12890	COG1770	oligopeptidase
D0T88_RS12895	COG2979	Protein of unknown function (DUF533)
D0T88_RS12905	COG3141	response to X-ray
D0T88_RS12915	COG0800	Aldolase
D0T88_RS12920	COG0129	dihydroxy-acid dehydratase activity
D0T88_RS12925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0T88_RS12930	COG1737	Transcriptional regulator
D0T88_RS12935	COG0469	pyruvate kinase activity
D0T88_RS12940	COG1560	Kdo2-lipid A biosynthetic process
D0T88_RS12945	COG0739	heme binding
D0T88_RS12950	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D0T88_RS12960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0T88_RS12990	COG0217	transcriptional regulatory protein
D0T88_RS12995	COG0494	nUDIX hydrolase
D0T88_RS13005	COG1335	isochorismatase
D0T88_RS13010	COG1801	Protein of unknown function DUF72
D0T88_RS13015	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D0T88_RS13030	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS13035	COG0243	molybdopterin cofactor binding
D0T88_RS13040	COG3005	denitrification pathway
D0T88_RS13050	COG3102	Protein conserved in bacteria
D0T88_RS13060	COG3755	Protein conserved in bacteria
D0T88_RS13070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0T88_RS13075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0T88_RS13080	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0T88_RS13085	COG0745	RESPONSE REGULATOR receiver
D0T88_RS13090	COG2201	protein-glutamate methylesterase activity
D0T88_RS13095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0T88_RS13100	COG0840	transmembrane signaling receptor activity
D0T88_RS13105	COG0840	transmembrane signaling receptor activity
D0T88_RS13110	COG0835	chemotaxis
D0T88_RS13115	COG0643	Histidine kinase
D0T88_RS13115	COG2198	Histidine kinase
D0T88_RS13120	COG1360	Flagellar Motor Protein
D0T88_RS13125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0T88_RS13140	COG0589	response to stress
D0T88_RS13150	COG1877	trehalose-phosphatase activity
D0T88_RS13155	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS13160	COG1129	ABC transporter
D0T88_RS13165	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS13170	COG1528	Iron-storage protein
D0T88_RS13190	COG1528	Iron-storage protein
D0T88_RS13200	COG0814	amino acid
D0T88_RS13205	COG3012	SEC-C Motif Domain Protein
D0T88_RS13205	COG3318	Belongs to the UPF0149 family
D0T88_RS13235	COG2197	response regulator
D0T88_RS13250	COG2197	response regulator
D0T88_RS13255	COG1126	abc transporter atp-binding protein
D0T88_RS13260	COG0765	amino acid transport
D0T88_RS13270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS13280	COG1191	sigma factor activity
D0T88_RS13295	COG1516	flagellar protein fliS
D0T88_RS13305	COG0366	Alpha amylase catalytic
D0T88_RS13315	COG2391	methyltransferase activity
D0T88_RS13320	COG0425	Belongs to the sulfur carrier protein TusA family
D0T88_RS13325	COG2135	peptidase activity
D0T88_RS13335	COG1766	The M ring may be actively involved in energy transduction
D0T88_RS13340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0T88_RS13345	COG1317	bacterial-type flagellum organization
D0T88_RS13350	COG1157	protein secretion by the type III secretion system
D0T88_RS13355	COG2882	bacterial-type flagellum organization
D0T88_RS13360	COG3144	bacterial-type flagellum assembly
D0T88_RS13365	COG1580	Controls the rotational direction of flagella during chemotaxis
D0T88_RS13370	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0T88_RS13375	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0T88_RS13380	COG3190	flagellar
D0T88_RS13385	COG1338	Plays a role in the flagellum-specific transport system
D0T88_RS13390	COG1987	bacterial-type flagellum assembly
D0T88_RS13395	COG1684	flagellar biosynthetic protein fliR
D0T88_RS13400	COG2197	response regulator
D0T88_RS13425	COG5475	Uncharacterized small protein (DUF2158)
D0T88_RS13430	COG2354	Protein conserved in bacteria
D0T88_RS13435	COG0697	spore germination
D0T88_RS13440	COG3727	T/G mismatch-specific endonuclease activity
D0T88_RS13445	COG0270	DNA (cytosine-5-)-methyltransferase activity
D0T88_RS13450	COG1418	mRNA catabolic process
D0T88_RS13460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0T88_RS13470	COG2205	protein histidine kinase activity
D0T88_RS13475	COG0745	RESPONSE REGULATOR receiver
D0T88_RS13480	COG2351	hydroxyisourate hydrolase activity
D0T88_RS13495	COG3443	Belongs to the bacterial solute-binding protein 9 family
D0T88_RS13500	COG3038	cytochrome b561
D0T88_RS13595	COG2916	Histone family protein nucleoid-structuring protein H-NS
D0T88_RS13645	COG0477	Major facilitator Superfamily
D0T88_RS13650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0T88_RS13655	COG0217	transcriptional regulatory protein
D0T88_RS13665	COG0534	Mate efflux family protein
D0T88_RS13675	COG0583	DNA-binding transcription factor activity
D0T88_RS13680	COG0583	DNA-binding transcription factor activity
D0T88_RS13690	COG1376	ErfK ybiS ycfS ynhG family protein
D0T88_RS13705	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
D0T88_RS13710	COG4917	ethanolamine utilization protein
D0T88_RS13720	COG1289	transmembrane transporter activity
D0T88_RS13730	COG1686	Belongs to the peptidase S11 family
D0T88_RS13735	COG2925	Exonuclease
D0T88_RS13740	COG0425	Belongs to the sulfur carrier protein TusA family
D0T88_RS13745	COG2391	methyltransferase activity
D0T88_RS13750	COG0531	amino acid
D0T88_RS13760	COG0583	DNA-binding transcription factor activity
D0T88_RS13765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0T88_RS13770	COG4115	mRNA cleavage
D0T88_RS13775	COG2161	toxin-antitoxin pair type II binding
D0T88_RS13790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0T88_RS13800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0T88_RS13800	COG0131	Imidazoleglycerol-phosphate dehydratase
D0T88_RS13805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0T88_RS13820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0T88_RS13820	COG0140	phosphoribosyl-ATP diphosphatase activity
D0T88_RS13830	COG0438	transferase activity, transferring glycosyl groups
D0T88_RS13840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0T88_RS13880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0T88_RS13895	COG1216	Glycosyl transferase, family 2
D0T88_RS13895	COG1442	glycosyl transferase family 8
D0T88_RS13920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0T88_RS13925	COG1091	dTDP-4-dehydrorhamnose reductase activity
D0T88_RS13930	COG1088	dTDP-glucose 4,6-dehydratase activity
D0T88_RS13935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0T88_RS13945	COG0438	transferase activity, transferring glycosyl groups
D0T88_RS13950	COG2327	Polysaccharide pyruvyl transferase
D0T88_RS13955	COG2244	polysaccharide biosynthetic process
D0T88_RS13960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0T88_RS13965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0T88_RS13970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D0T88_RS13970	COG0662	Cupin 2, conserved barrel domain protein
D0T88_RS13975	COG0297	glycogen (starch) synthase activity
D0T88_RS13980	COG1051	belongs to the nudix hydrolase family
D0T88_RS13985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0T88_RS13990	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D0T88_RS13995	COG0110	maltose O-acetyltransferase activity
D0T88_RS14000	COG1216	Glycosyl transferase, family 2
D0T88_RS14010	COG0438	transferase activity, transferring glycosyl groups
D0T88_RS14015	COG1045	serine acetyltransferase
D0T88_RS14020	COG0463	Glycosyl transferase, family 2
D0T88_RS14025	COG0489	protein tyrosine kinase activity
D0T88_RS14025	COG3206	protein involved in exopolysaccharide biosynthesis
D0T88_RS14030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0T88_RS14035	COG1596	polysaccharide export
D0T88_RS14045	COG1253	flavin adenine dinucleotide binding
D0T88_RS14050	COG2982	Protein involved in outer membrane biogenesis
D0T88_RS14060	COG0572	uridine kinase
D0T88_RS14065	COG5001	Diguanylate cyclase
D0T88_RS14065	COG5002	protein histidine kinase activity
D0T88_RS14065	COG3447	MASE1 domain protein
D0T88_RS14070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0T88_RS14075	COG0443	Heat shock 70 kDa protein
D0T88_RS14080	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
D0T88_RS14085	COG0631	protein serine/threonine phosphatase activity
D0T88_RS14090	COG4245	von Willebrand factor, type A
D0T88_RS14130	COG2205	protein histidine kinase activity
D0T88_RS14135	COG0745	RESPONSE REGULATOR receiver
D0T88_RS14145	COG3609	addiction module antidote protein, CC2985 family
D0T88_RS14155	COG0826	peptidase U32
D0T88_RS14175	COG1063	alcohol dehydrogenase
D0T88_RS14180	COG3775	system Galactitol-specific IIC component
D0T88_RS14185	COG3414	Phosphotransferase system galactitol-specific IIB component
D0T88_RS14190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS14205	COG1830	Aldolase
D0T88_RS14210	COG2211	Major facilitator Superfamily
D0T88_RS14215	COG1397	ADP-ribosylglycohydrolase
D0T88_RS14220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS14225	COG2188	Transcriptional regulator
D0T88_RS14230	COG3757	hydrolase, family 25
D0T88_RS14235	COG0351	phosphomethylpyrimidine kinase
D0T88_RS14255	COG5455	response to cobalt ion
D0T88_RS14260	COG3539	Fimbrial protein
D0T88_RS14265	COG3188	usher protein
D0T88_RS14270	COG3121	Chaperone
D0T88_RS14275	COG3539	Fimbrial protein
D0T88_RS14285	COG0489	protein tyrosine kinase activity
D0T88_RS14295	COG3831	ATPase activity
D0T88_RS14300	COG3831	ATPase activity
D0T88_RS14310	COG0714	Associated with various cellular activities
D0T88_RS14315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0T88_RS14320	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D0T88_RS14325	COG4715	Zinc finger, swim domain protein
D0T88_RS14330	COG4808	Protein conserved in bacteria
D0T88_RS14335	COG4807	Protein conserved in bacteria
D0T88_RS14340	COG3279	Response regulator of the LytR AlgR family
D0T88_RS14345	COG3275	phosphorelay sensor kinase activity
D0T88_RS14350	COG0789	Transcriptional regulator
D0T88_RS14360	COG1174	glycine betaine transport
D0T88_RS14365	COG1125	glycine betaine transport
D0T88_RS14370	COG1174	glycine betaine transport
D0T88_RS14375	COG1732	Glycine betaine
D0T88_RS14380	COG1472	Belongs to the glycosyl hydrolase 3 family
D0T88_RS14385	COG0277	FAD linked oxidase domain protein
D0T88_RS14390	COG1686	Belongs to the peptidase S11 family
D0T88_RS14400	COG0586	Pfam SNARE associated Golgi protein
D0T88_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS14420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0T88_RS14430	COG1346	cytolysis
D0T88_RS14440	COG2949	membrane
D0T88_RS14450	COG0493	'glutamate synthase
D0T88_RS14455	COG0167	dihydroorotate dehydrogenase activity
D0T88_RS14455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0T88_RS14460	COG4211	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS14465	COG1129	ABC transporter
D0T88_RS14470	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS14475	COG1609	Transcriptional regulator
D0T88_RS14480	COG2311	Membrane
D0T88_RS14495	COG4771	TonB-dependent receptor
D0T88_RS14500	COG0833	amino acid
D0T88_RS14505	COG0583	DNA-binding transcription factor activity
D0T88_RS14510	COG2855	membrane
D0T88_RS14520	COG1522	sequence-specific DNA binding
D0T88_RS14520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS14525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0T88_RS14535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0T88_RS14540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0T88_RS14545	COG2313	pseudouridylate synthase activity
D0T88_RS14550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS14555	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0T88_RS14555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS14555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS14560	COG1105	Belongs to the carbohydrate kinase PfkB family
D0T88_RS14565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS14565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS14570	COG2814	Major facilitator Superfamily
D0T88_RS14585	COG0246	Mannitol dehydrogenase
D0T88_RS14590	COG0523	cobalamin synthesis protein
D0T88_RS14595	COG0671	phosphoesterase, PA-phosphatase related
D0T88_RS14600	COG0791	NLP P60 protein
D0T88_RS14605	COG2200	EAL domain
D0T88_RS14610	COG4166	transmembrane transport
D0T88_RS14615	COG4174	ABC transporter (Permease)
D0T88_RS14620	COG4239	(ABC) transporter, permease
D0T88_RS14625	COG4172	Belongs to the ABC transporter superfamily
D0T88_RS14635	COG2814	Major facilitator Superfamily
D0T88_RS14640	COG1187	pseudouridine synthase activity
D0T88_RS14645	COG1061	Type III restriction enzyme res subunit
D0T88_RS14665	COG3083	sulfuric ester hydrolase activity
D0T88_RS14680	COG2197	response regulator
D0T88_RS14685	COG4235	cytochrome complex assembly
D0T88_RS14685	COG3088	subunit of a heme lyase
D0T88_RS14690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0T88_RS14695	COG1138	Cytochrome C-type biogenesis protein
D0T88_RS14705	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0T88_RS14710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0T88_RS14715	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0T88_RS14725	COG3005	denitrification pathway
D0T88_RS14730	COG3043	anaerobic respiration
D0T88_RS14735	COG0348	domain, Protein
D0T88_RS14740	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS14750	COG3062	negative regulation of establishment of protein localization
D0T88_RS14755	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS14755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS14775	COG4615	Cyclic peptide transporter
D0T88_RS14780	COG3145	DNA-N1-methyladenine dioxygenase activity
D0T88_RS14785	COG2169	Transcriptional regulator
D0T88_RS14785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0T88_RS14790	COG1477	protein flavinylation
D0T88_RS14795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0T88_RS14800	COG0642	Histidine kinase
D0T88_RS14800	COG2198	Histidine kinase
D0T88_RS14805	COG2197	response regulator
D0T88_RS14810	COG0784	Response regulator, receiver
D0T88_RS14810	COG2205	protein histidine kinase activity
D0T88_RS14815	COG4676	Protein conserved in bacteria
D0T88_RS14820	COG5445	Predicted secreted protein (DUF2300)
D0T88_RS14825	COG2373	Large extracellular alpha-helical protein
D0T88_RS14830	COG3234	Protein of unknown function (DUF1175)
D0T88_RS14835	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
D0T88_RS14840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0T88_RS14850	COG3468	outer membrane autotransporter barrel domain protein
D0T88_RS14855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0T88_RS14860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0T88_RS14865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0T88_RS14870	COG3642	lipopolysaccharide core region biosynthetic process
D0T88_RS14880	COG0584	glycerophosphoryl diester phosphodiesterase
D0T88_RS14885	COG2271	Major facilitator Superfamily
D0T88_RS14890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0T88_RS14900	COG0247	lactate metabolic process
D0T88_RS14905	COG5464	transposase or invertase
D0T88_RS14975	COG0318	PFAM AMP-dependent synthetase and ligase
D0T88_RS14985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0T88_RS15000	COG1169	isochorismate synthase
D0T88_RS15005	COG4575	ribosome binding
D0T88_RS15010	COG2153	protein acetylation
D0T88_RS15040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0T88_RS15045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0T88_RS15055	COG0839	Belongs to the complex I subunit 6 family
D0T88_RS15070	COG1034	ATP synthesis coupled electron transport
D0T88_RS15075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D0T88_RS15080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D0T88_RS15100	COG0583	DNA-binding transcription factor activity
D0T88_RS15105	COG0436	Aminotransferase
D0T88_RS15115	COG0471	metal ion transport
D0T88_RS15115	COG0490	domain, Protein
D0T88_RS15120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0T88_RS15135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0T88_RS15140	COG0280	phosphate acetyltransferase
D0T88_RS15140	COG0857	belongs to the CobB CobQ family
D0T88_RS15145	COG1288	antiporter activity
D0T88_RS15150	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D0T88_RS15155	COG0622	Phosphoesterase
D0T88_RS15160	COG0625	glutathione transferase activity
D0T88_RS15165	COG0625	glutathione transferase activity
D0T88_RS15170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0T88_RS15175	COG1090	epimerase
D0T88_RS15180	COG5464	transposase or invertase
D0T88_RS15185	COG4598	ABC transporter
D0T88_RS15190	COG4160	amino acid transport
D0T88_RS15195	COG4215	(ABC) transporter
D0T88_RS15200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS15205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS15210	COG0163	prenyltransferase activity
D0T88_RS15215	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0T88_RS15220	COG1286	toxin biosynthetic process
D0T88_RS15225	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0T88_RS15230	COG0285	dihydrofolate synthase activity
D0T88_RS15240	COG0586	Pfam SNARE associated Golgi protein
D0T88_RS15250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0T88_RS15260	COG4974	Belongs to the 'phage' integrase family
D0T88_RS15340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0T88_RS15355	COG4695	Portal protein
D0T88_RS15435	COG5301	cellulose 1,4-beta-cellobiosidase activity
D0T88_RS15455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0T88_RS15520	COG2814	Major facilitator Superfamily
D0T88_RS15525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0T88_RS15535	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS15545	COG3101	peptidyl-lysine hydroxylation
D0T88_RS15550	COG0730	response to heat
D0T88_RS15580	COG3539	Fimbrial protein
D0T88_RS15585	COG3539	Fimbrial protein
D0T88_RS15590	COG3539	Fimbrial protein
D0T88_RS15595	COG3121	Chaperone
D0T88_RS15600	COG3188	usher protein
D0T88_RS15605	COG3539	Fimbrial protein
D0T88_RS15610	COG2062	phosphohistidine phosphatase, SixA
D0T88_RS15625	COG3691	Protein conserved in bacteria
D0T88_RS15630	COG2067	long-chain fatty acid transport protein
D0T88_RS15640	COG2853	Lipoprotein
D0T88_RS15645	COG2116	formate transmembrane transporter activity
D0T88_RS15655	COG0582	viral genome integration into host DNA
D0T88_RS15700	COG3718	enzyme involved in inositol metabolism
D0T88_RS15710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS15715	COG0673	inositol 2-dehydrogenase activity
D0T88_RS15720	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS15735	COG0673	inositol 2-dehydrogenase activity
D0T88_RS15740	COG3962	Belongs to the TPP enzyme family
D0T88_RS15770	COG1169	isochorismate synthase
D0T88_RS15775	COG2814	Major facilitator Superfamily
D0T88_RS15780	COG1132	(ABC) transporter
D0T88_RS15795	COG3433	isochorismatase activity
D0T88_RS15795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0T88_RS15795	COG2226	methyltransferase
D0T88_RS15815	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0T88_RS15820	COG4771	TonB-dependent receptor
D0T88_RS15825	COG4771	TonB-dependent receptor
D0T88_RS15835	COG0500	methyltransferase
D0T88_RS15850	COG1475	DNA binding
D0T88_RS15855	COG3969	phosphoadenosine phosphosulfate
D0T88_RS15910	COG2382	esterase
D0T88_RS15915	COG2819	hydrolase of the alpha beta superfamily
D0T88_RS15920	COG4771	TonB-dependent receptor
D0T88_RS15925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0T88_RS15945	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS15950	COG4372	Transposase
D0T88_RS15975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0T88_RS15980	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS16010	COG4372	Transposase
D0T88_RS16015	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS16025	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS16030	COG4372	Transposase
D0T88_RS16045	COG3468	outer membrane autotransporter barrel domain protein
D0T88_RS16075	COG2003	Belongs to the UPF0758 family
D0T88_RS16120	COG0477	Major facilitator Superfamily
D0T88_RS16125	COG1566	PFAM secretion protein HlyD family protein
D0T88_RS16130	COG2197	response regulator
D0T88_RS16135	COG0784	Response regulator, receiver
D0T88_RS16135	COG2205	protein histidine kinase activity
D0T88_RS16135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS16135	COG2198	Histidine kinase
D0T88_RS16140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0T88_RS16145	COG0679	Auxin Efflux Carrier
D0T88_RS16150	COG0028	Belongs to the TPP enzyme family
D0T88_RS16175	COG1560	Kdo2-lipid A biosynthetic process
D0T88_RS16185	COG0436	Aminotransferase
D0T88_RS16190	COG3275	phosphorelay sensor kinase activity
D0T88_RS16195	COG3279	Response regulator of the LytR AlgR family
D0T88_RS16200	COG2207	Transcriptional regulator
D0T88_RS16210	COG1363	Peptidase, m42
D0T88_RS16215	COG0006	proline dipeptidase activity
D0T88_RS16220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS16225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS16250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0T88_RS16255	COG2199	diguanylate cyclase activity
D0T88_RS16255	COG2200	EAL domain
D0T88_RS16270	COG3415	Transposase
D0T88_RS16275	COG3415	Transposase
D0T88_RS16305	COG0583	DNA-binding transcription factor activity
D0T88_RS16315	COG2211	Major facilitator Superfamily
D0T88_RS16320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0T88_RS16330	COG0583	DNA-binding transcription factor activity
D0T88_RS16335	COG0385	Bile acid
D0T88_RS16340	COG3530	Putative quorum-sensing-regulated virulence factor
D0T88_RS16360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0T88_RS16365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS16370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0T88_RS16375	COG2190	(PTS) system
D0T88_RS16390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0T88_RS16395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D0T88_RS16400	COG4208	sulfate ABC transporter
D0T88_RS16405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D0T88_RS16410	COG4150	thiosulfate binding
D0T88_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS16430	COG1263	PTS System
D0T88_RS16430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS16435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0T88_RS16440	COG2837	iron assimilation
D0T88_RS16460	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0T88_RS16470	COG2207	Transcriptional regulator
D0T88_RS16475	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D0T88_RS16480	COG4816	utilization protein
D0T88_RS16490	COG4303	Ethanolamine ammonia lyase large subunit
D0T88_RS16495	COG4819	ethanolamine utilization protein
D0T88_RS16500	COG3192	ethanolamine utilization protein
D0T88_RS16505	COG1454	alcohol dehydrogenase
D0T88_RS16510	COG4820	ethanolamine utilization protein (EutJ)
D0T88_RS16515	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS16520	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
D0T88_RS16525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D0T88_RS16530	COG0280	phosphate acetyltransferase
D0T88_RS16535	COG4812	Cobalamin adenosyltransferase
D0T88_RS16540	COG4766	ethanolamine catabolic process
D0T88_RS16545	COG4917	ethanolamine utilization protein
D0T88_RS16550	COG4810	utilization protein
D0T88_RS16555	COG0281	malic enzyme
D0T88_RS16555	COG0280	phosphate acetyltransferase
D0T88_RS16560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0T88_RS16565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0T88_RS16570	COG5342	invasion associated locus B
D0T88_RS16580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS16580	COG0493	'glutamate synthase
D0T88_RS16585	COG3850	Histidine kinase
D0T88_RS16590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0T88_RS16600	COG1393	Belongs to the ArsC family
D0T88_RS16615	COG0400	carboxylic ester hydrolase activity
D0T88_RS16625	COG2321	neutral zinc metallopeptidase
D0T88_RS16645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D0T88_RS16655	COG2716	regulation of RNA biosynthetic process
D0T88_RS16660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0T88_RS16665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS16675	COG0650	Formate hydrogenlyase subunit 4
D0T88_RS16680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0T88_RS16685	COG4237	Hydrogenase 4 membrane
D0T88_RS16690	COG0651	ATP synthesis coupled electron transport
D0T88_RS16695	COG3261	NADH dehydrogenase
D0T88_RS16695	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D0T88_RS16700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0T88_RS16715	COG3604	Transcriptional regulator
D0T88_RS16720	COG2116	formate transmembrane transporter activity
D0T88_RS16725	COG0628	permease
D0T88_RS16730	COG4783	chaperone-mediated protein folding
D0T88_RS16735	COG1393	Belongs to the ArsC family
D0T88_RS16745	COG2233	PERMEase
D0T88_RS16760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0T88_RS16765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0T88_RS16770	COG0248	Ppx GppA phosphatase
D0T88_RS16775	COG2200	EAL domain
D0T88_RS16790	COG3133	Outer membrane lipoprotein
D0T88_RS16805	COG0517	IMP dehydrogenase activity
D0T88_RS16805	COG0516	GMP reductase activity
D0T88_RS16815	COG1645	bacterial-type flagellum-dependent swarming motility
D0T88_RS16830	COG2976	Protein conserved in bacteria
D0T88_RS16860	COG4953	penicillin-binding protein 1C
D0T88_RS16865	COG2373	Large extracellular alpha-helical protein
D0T88_RS16870	COG2897	thiosulfate sulfurtransferase activity
D0T88_RS16885	COG2975	iron-sulfur cluster assembly
D0T88_RS16890	COG0633	Ferredoxin
D0T88_RS16910	COG0822	iron-sulfur transferase activity
D0T88_RS16930	COG0483	inositol monophosphate 1-phosphatase activity
D0T88_RS16935	COG1073	alpha beta
D0T88_RS16940	COG3711	transcriptional antiterminator
D0T88_RS16945	COG2814	Major facilitator Superfamily
D0T88_RS16950	COG0583	DNA-binding transcription factor activity
D0T88_RS16955	COG4638	Rieske (2fe-2S)
D0T88_RS16980	COG2259	Doxx family
D0T88_RS16985	COG2017	converts alpha-aldose to the beta-anomer
D0T88_RS16990	COG1063	alcohol dehydrogenase
D0T88_RS16995	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS17000	COG1129	ABC transporter
D0T88_RS17005	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS17010	COG0457	Tetratricopeptide repeat
D0T88_RS17015	COG1940	carbohydrate kinase activity
D0T88_RS17025	COG1017	nitric oxide dioxygenase activity
D0T88_RS17025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0T88_RS17030	COG0347	Belongs to the P(II) protein family
D0T88_RS17035	COG2204	response regulator
D0T88_RS17040	COG3170	Tfp pilus assembly protein FimV
D0T88_RS17045	COG2205	protein histidine kinase activity
D0T88_RS17065	COG0560	Phosphoserine phosphatase
D0T88_RS17070	COG1737	Transcriptional regulator
D0T88_RS17075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS17090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0T88_RS17110	COG0681	Belongs to the peptidase S26 family
D0T88_RS17120	COG3086	response to oxidative stress
D0T88_RS17125	COG3026	antisigma factor binding
D0T88_RS17130	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D0T88_RS17135	COG1595	DNA-templated transcription, initiation
D0T88_RS17145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0T88_RS17155	COG0513	Belongs to the DEAD box helicase family
D0T88_RS17160	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS17165	COG0583	DNA-binding transcription factor activity
D0T88_RS17185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0T88_RS17190	COG3118	belongs to the thioredoxin family
D0T88_RS17195	COG3148	PFAM DTW domain containing protein
D0T88_RS17200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0T88_RS17200	COG1042	CoA-binding domain protein
D0T88_RS17200	COG0045	succinate-CoA ligase (ADP-forming) activity
D0T88_RS17205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0T88_RS17210	COG5544	Lipoprotein
D0T88_RS17215	COG0477	Major facilitator Superfamily
D0T88_RS17240	COG0542	response to heat
D0T88_RS17245	COG1496	oxidoreductase activity
D0T88_RS17250	COG0564	pseudouridine synthase activity
D0T88_RS17255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0T88_RS17260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0T88_RS17270	COG0077	Prephenate dehydratase
D0T88_RS17270	COG1605	Chorismate mutase
D0T88_RS17275	COG0287	Prephenate dehydrogenase
D0T88_RS17275	COG1605	Chorismate mutase
D0T88_RS17280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0T88_RS17295	COG2199	diguanylate cyclase activity
D0T88_RS17300	COG2885	chlorophyll binding
D0T88_RS17325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0T88_RS17330	COG4137	Cytochrome C assembly protein
D0T88_RS17335	COG4536	flavin adenine dinucleotide binding
D0T88_RS17355	COG0497	DNA recombination
D0T88_RS17360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0T88_RS17370	COG2867	negative regulation of translational initiation
D0T88_RS17385	COG0582	viral genome integration into host DNA
D0T88_RS17440	COG0582	viral genome integration into host DNA
D0T88_RS17475	COG0579	oxidoreductase
D0T88_RS17480	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS17485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0T88_RS17490	COG1113	amino acid transport
D0T88_RS17495	COG1802	Transcriptional regulator
D0T88_RS17500	COG1652	LysM domain
D0T88_RS17505	COG0401	homolog of Blt101
D0T88_RS17510	COG0640	Transcriptional regulator
D0T88_RS17515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0T88_RS17520	COG2916	Histone family protein nucleoid-structuring protein H-NS
D0T88_RS17535	COG4575	ribosome binding
D0T88_RS17540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0T88_RS17550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0T88_RS17555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0T88_RS17560	COG4175	Glycine betaine
D0T88_RS17565	COG4176	ABC-type proline glycine betaine transport system permease component
D0T88_RS17570	COG2113	Glycine betaine
D0T88_RS17575	COG2814	Major facilitator Superfamily
D0T88_RS17580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D0T88_RS17590	COG1846	Transcriptional regulator
D0T88_RS17595	COG1566	PFAM secretion protein HlyD family protein
D0T88_RS17600	COG2814	Major facilitator Superfamily
D0T88_RS17615	COG1238	metal cluster binding
D0T88_RS17620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0T88_RS17650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D0T88_RS17670	COG1546	Belongs to the CinA family
D0T88_RS17675	COG2951	lytic endotransglycosylase activity
D0T88_RS17680	COG3730	PTS system glucitol sorbitol-specific
D0T88_RS17685	COG3732	PTS system glucitol sorbitol-specific
D0T88_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS17700	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS17705	COG1349	DNA-binding transcription factor activity
D0T88_RS17730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D0T88_RS17735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS17740	COG1609	Transcriptional regulator
D0T88_RS17745	COG1263	PTS System
D0T88_RS17745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS17750	COG2723	6-phospho-beta-galactosidase activity
D0T88_RS17755	COG5499	transcription regulator containing HTH domain
D0T88_RS17765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D0T88_RS17775	COG3260	NADH ubiquinone oxidoreductase 20
D0T88_RS17780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0T88_RS17785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D0T88_RS17785	COG3261	NADH dehydrogenase
D0T88_RS17790	COG0650	Formate hydrogenlyase subunit 4
D0T88_RS17795	COG0651	ATP synthesis coupled electron transport
D0T88_RS17800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS17810	COG0375	protein maturation
D0T88_RS17815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0T88_RS17820	COG0298	carbon dioxide binding
D0T88_RS17825	COG0409	Hydrogenase expression formation protein
D0T88_RS17830	COG0309	Hydrogenase expression formation protein (HypE)
D0T88_RS17835	COG3604	Transcriptional regulator
D0T88_RS17860	COG1349	DNA-binding transcription factor activity
D0T88_RS17865	COG2084	Dehydrogenase
D0T88_RS17870	COG3395	kinase activity
D0T88_RS17875	COG0235	Class ii aldolase
D0T88_RS17880	COG3622	Belongs to the hyi family
D0T88_RS17885	COG2610	gluconate transmembrane transporter activity
D0T88_RS17895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0T88_RS17910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0T88_RS17915	COG4942	peptidase
D0T88_RS17915	COG1388	LysM domain
D0T88_RS17970	COG2234	aminopeptidase activity
D0T88_RS17975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0T88_RS17980	COG1518	maintenance of DNA repeat elements
D0T88_RS17995	COG1857	crispr-associated protein
D0T88_RS18010	COG1203	CRISPR-associated helicase, Cas3
D0T88_RS18035	COG0720	synthase
D0T88_RS18040	COG0644	oxidoreductase
D0T88_RS18045	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D0T88_RS18050	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D0T88_RS18055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D0T88_RS18060	COG2086	electron transfer activity
D0T88_RS18065	COG0477	Major facilitator Superfamily
D0T88_RS18070	COG0277	FAD linked oxidase domain protein
D0T88_RS18075	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS18080	COG2223	nitrite transmembrane transporter activity
D0T88_RS18085	COG1070	Carbohydrate kinase
D0T88_RS18090	COG0602	queuosine metabolic process
D0T88_RS18100	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D0T88_RS18115	COG3956	TIGRFAM MazG family protein
D0T88_RS18120	COG2337	Toxic component of a toxin-antitoxin (TA) module
D0T88_RS18125	COG2336	PFAM SpoVT AbrB
D0T88_RS18130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0T88_RS18140	COG4999	Histidine kinase
D0T88_RS18140	COG3437	response regulator, receiver
D0T88_RS18140	COG2205	protein histidine kinase activity
D0T88_RS18140	COG3850	Histidine kinase
D0T88_RS18145	COG4948	Mandelate Racemase Muconate Lactonizing
D0T88_RS18150	COG4948	Mandelate Racemase Muconate Lactonizing
D0T88_RS18155	COG2271	Major facilitator Superfamily
D0T88_RS18160	COG0716	FMN binding
D0T88_RS18165	COG0564	pseudouridine synthase activity
D0T88_RS18170	COG3098	single-species biofilm formation
D0T88_RS18185	COG1611	Belongs to the LOG family
D0T88_RS18190	COG0814	amino acid
D0T88_RS18195	COG1760	l-serine dehydratase
D0T88_RS18205	COG1454	alcohol dehydrogenase
D0T88_RS18210	COG0235	Class ii aldolase
D0T88_RS18215	COG0738	Major facilitator superfamily
D0T88_RS18225	COG1070	Carbohydrate kinase
D0T88_RS18235	COG1349	DNA-binding transcription factor activity
D0T88_RS18245	COG2363	Small membrane protein
D0T88_RS18250	COG0583	DNA-binding transcription factor activity
D0T88_RS18260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0T88_RS18265	COG2166	iron-sulfur cluster assembly
D0T88_RS18270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0T88_RS18275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0T88_RS18295	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0T88_RS18300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0T88_RS18300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0T88_RS18305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0T88_RS18310	COG1074	ATP-dependent DNA helicase activity
D0T88_RS18320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0T88_RS18325	COG4967	type IV pilus modification protein PilV
D0T88_RS18335	COG4795	General secretion pathway protein
D0T88_RS18340	COG2165	general secretion pathway protein
D0T88_RS18355	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D0T88_RS18370	COG0861	Integral membrane protein TerC family
D0T88_RS18380	COG0667	Aldo Keto reductase
D0T88_RS18395	COG1609	Transcriptional regulator
D0T88_RS18405	COG0583	DNA-binding transcription factor activity
D0T88_RS18410	COG1794	racemase activity, acting on amino acids and derivatives
D0T88_RS18415	COG2814	Major facilitator Superfamily
D0T88_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS18430	COG0183	Belongs to the thiolase family
D0T88_RS18435	COG0814	amino acid
D0T88_RS18440	COG2771	luxR family
D0T88_RS18445	COG3710	Transcriptional regulator
D0T88_RS18470	COG0457	Tetratricopeptide repeat
D0T88_RS18475	COG3710	Transcriptional regulator
D0T88_RS18475	COG0457	Tetratricopeptide repeat
D0T88_RS18570	COG3387	PFAM Glycoside hydrolase 15-related
D0T88_RS18580	COG4942	peptidase
D0T88_RS18585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0T88_RS18590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0T88_RS18595	COG2080	2 iron, 2 sulfur cluster binding
D0T88_RS18600	COG3829	transcription factor binding
D0T88_RS18605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0T88_RS18610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0T88_RS18615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0T88_RS18625	COG0549	Belongs to the carbamate kinase family
D0T88_RS18630	COG3608	succinylglutamate desuccinylase aspartoacylase
D0T88_RS18630	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D0T88_RS18635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0T88_RS18640	COG2068	MobA-Related Protein
D0T88_RS18645	COG0493	'glutamate synthase
D0T88_RS18645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS18650	COG0402	S-adenosylhomocysteine deaminase activity
D0T88_RS18655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0T88_RS18660	COG2080	2 iron, 2 sulfur cluster binding
D0T88_RS18660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0T88_RS18665	COG2233	PERMEase
D0T88_RS18670	COG0402	S-adenosylhomocysteine deaminase activity
D0T88_RS18680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS18685	COG0493	'glutamate synthase
D0T88_RS18685	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS18690	COG2233	PERMEase
D0T88_RS18720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0T88_RS18725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0T88_RS18730	COG4974	Belongs to the 'phage' integrase family
D0T88_RS18735	COG0716	FMN binding
D0T88_RS18745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0T88_RS18755	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS18760	COG1272	protein, Hemolysin III
D0T88_RS18770	COG2723	6-phospho-beta-galactosidase activity
D0T88_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS18800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0T88_RS18805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0T88_RS18810	COG0006	proline dipeptidase activity
D0T88_RS18830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0T88_RS18845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0T88_RS18865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0T88_RS18865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0T88_RS18870	COG1703	isobutyryl-CoA mutase activity
D0T88_RS18875	COG1024	Enoyl-CoA hydratase
D0T88_RS18880	COG0427	acetyl-CoA hydrolase
D0T88_RS18885	COG0583	DNA-binding transcription factor activity
D0T88_RS18890	COG2968	Membrane
D0T88_RS18900	COG0668	transmembrane transport
D0T88_RS18905	COG0191	fructose-bisphosphate aldolase activity
D0T88_RS18935	COG1122	ATPase activity
D0T88_RS18940	COG1122	ATPase activity
D0T88_RS18945	COG1072	(Pantothenic acid kinase))
D0T88_RS18955	COG1494	fructose-1,6-bisphosphatase
D0T88_RS18960	COG1063	alcohol dehydrogenase
D0T88_RS18965	COG2213	PTS system mannitol-specific
D0T88_RS18970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS18975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0T88_RS18980	COG0501	Belongs to the peptidase M48B family
D0T88_RS18995	COG3716	PTS system mannose fructose sorbose family IID component
D0T88_RS19000	COG3715	PTS system
D0T88_RS19005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS19005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS19030	COG1166	arginine decarboxylase activity
D0T88_RS19050	COG2814	Major facilitator Superfamily
D0T88_RS19060	COG2356	endonuclease I
D0T88_RS19065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0T88_RS19070	COG0189	ligase activity
D0T88_RS19085	COG2805	Type II/IV secretion system protein
D0T88_RS19090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0T88_RS19095	COG0762	integral membrane protein
D0T88_RS19110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0T88_RS19120	COG0252	asparaginase activity
D0T88_RS19130	COG3171	Protein conserved in bacteria
D0T88_RS19140	COG1194	a g-specific adenine glycosylase
D0T88_RS19155	COG2211	Major facilitator Superfamily
D0T88_RS19160	COG1982	Orn Lys Arg decarboxylase major
D0T88_RS19165	COG1811	Na channel or pump
D0T88_RS19175	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0T88_RS19205	COG2165	general secretion pathway protein
D0T88_RS19210	COG1459	type II secretion system
D0T88_RS19215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0T88_RS19240	COG3064	Membrane
D0T88_RS19245	COG1620	l-lactate permease
D0T88_RS19250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0T88_RS19255	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D0T88_RS19260	COG0247	lactate metabolic process
D0T88_RS19265	COG0277	FAD linked oxidase domain protein
D0T88_RS19270	COG0277	FAD linked oxidase domain protein
D0T88_RS19275	COG2186	Transcriptional regulator
D0T88_RS19280	COG0456	acetyltransferase
D0T88_RS19285	COG0318	PFAM AMP-dependent synthetase and ligase
D0T88_RS19295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0T88_RS19300	COG0156	8-amino-7-oxononanoate synthase activity
D0T88_RS19310	COG0795	lipopolysaccharide-transporting ATPase activity
D0T88_RS19315	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0T88_RS19325	COG2244	polysaccharide biosynthetic process
D0T88_RS19330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0T88_RS19335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0T88_RS19340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0T88_RS19345	COG0306	phosphate transporter
D0T88_RS19350	COG0754	glutathionylspermidine amidase activity
D0T88_RS19355	COG0625	glutathione transferase activity
D0T88_RS19360	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS19365	COG0298	carbon dioxide binding
D0T88_RS19370	COG0375	protein maturation
D0T88_RS19375	COG1773	rubredoxin
D0T88_RS19380	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D0T88_RS19385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D0T88_RS19390	COG5557	Pfam Polysulphide reductase, NrfD
D0T88_RS19395	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS19400	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D0T88_RS19415	COG0667	Aldo Keto reductase
D0T88_RS19425	COG1028	Short-chain dehydrogenase reductase Sdr
D0T88_RS19430	COG0848	biopolymer transport protein
D0T88_RS19435	COG0811	peptide transport
D0T88_RS19440	COG0626	cystathionine gamma-synthase activity
D0T88_RS19445	COG0586	Pfam SNARE associated Golgi protein
D0T88_RS19450	COG2207	Transcriptional regulator
D0T88_RS19455	COG1979	alcohol dehydrogenase
D0T88_RS19460	COG0656	L-ascorbic acid biosynthetic process
D0T88_RS19470	COG4238	major outer membrane lipoprotein
D0T88_RS19475	COG1032	radical SAM domain protein
D0T88_RS19480	COG2132	Multicopper oxidase
D0T88_RS19485	COG0204	Acyl-transferase
D0T88_RS19490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0T88_RS19495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D0T88_RS19500	COG3111	PFAM Bacterial OB fold (BOF) protein
D0T88_RS19505	COG0745	RESPONSE REGULATOR receiver
D0T88_RS19510	COG0642	Histidine kinase
D0T88_RS19520	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0T88_RS19525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D0T88_RS19530	COG2211	Major facilitator Superfamily
D0T88_RS19550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS19570	COG0187	DNA topoisomerase II activity
D0T88_RS19575	COG3150	esterase
D0T88_RS19580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0T88_RS19585	COG3151	Protein conserved in bacteria
D0T88_RS19590	COG0494	nUDIX hydrolase
D0T88_RS19595	COG1538	Outer membrane efflux protein
D0T88_RS19605	COG0754	glutathionylspermidine amidase activity
D0T88_RS19610	COG3384	dioxygenase
D0T88_RS19630	COG2960	long-chain fatty acid transporting porin activity
D0T88_RS19635	COG3539	Fimbrial protein
D0T88_RS19640	COG3188	usher protein
D0T88_RS19645	COG3121	Chaperone
D0T88_RS19650	COG3121	Chaperone
D0T88_RS19655	COG3539	Fimbrial protein
D0T88_RS19665	COG1585	Membrane protein implicated in regulation of membrane protease activity
D0T88_RS19670	COG2268	Band 7 protein
D0T88_RS19695	COG3025	triphosphatase activity
D0T88_RS19700	COG4991	sh3 domain protein
D0T88_RS19715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0T88_RS19725	COG0583	DNA-binding transcription factor activity
D0T88_RS19730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0T88_RS19735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0T88_RS19740	COG0471	metal ion transport
D0T88_RS19750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0T88_RS19755	COG0358	DNA primase activity
D0T88_RS19760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0T88_RS19775	COG2375	cellular response to nickel ion
D0T88_RS19780	COG1695	Transcriptional regulator
D0T88_RS19785	COG0840	transmembrane signaling receptor activity
D0T88_RS19795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0T88_RS19800	COG1609	Transcriptional regulator
D0T88_RS19805	COG3250	beta-galactosidase activity
D0T88_RS19810	COG2731	YhcH YjgK YiaL family protein
D0T88_RS19815	COG0531	amino acid
D0T88_RS19825	COG3408	Glycogen debranching enzyme
D0T88_RS19825	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0T88_RS19830	COG1902	pentaerythritol trinitrate reductase activity
D0T88_RS19830	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0T88_RS19835	COG5499	transcription regulator containing HTH domain
D0T88_RS19850	COG1451	nucleotide metabolic process
D0T88_RS19855	COG2949	membrane
D0T88_RS19860	COG0673	inositol 2-dehydrogenase activity
D0T88_RS19865	COG0861	Integral membrane protein TerC family
D0T88_RS19870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D0T88_RS19880	COG2721	sulfolactate sulfo-lyase activity
D0T88_RS19890	COG2271	Major facilitator Superfamily
D0T88_RS19915	COG2186	Transcriptional regulator
D0T88_RS19920	COG0586	Pfam SNARE associated Golgi protein
D0T88_RS19930	COG1422	Protein of unknown function (DUF1090)
D0T88_RS19935	COG4575	ribosome binding
D0T88_RS19940	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
D0T88_RS19950	COG2259	Doxx family
D0T88_RS19955	COG0435	Glutathione S-transferase
D0T88_RS19960	COG3152	Membrane
D0T88_RS19965	COG3152	Membrane
D0T88_RS19970	COG0583	DNA-binding transcription factor activity
D0T88_RS19975	COG1741	Belongs to the pirin family
D0T88_RS19990	COG0814	amino acid
D0T88_RS19995	COG1760	l-serine dehydratase
D0T88_RS20000	COG0251	oxidation-reduction process
D0T88_RS20005	COG1882	Formate acetyltransferase
D0T88_RS20010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0T88_RS20020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0T88_RS20025	COG0583	DNA-binding transcription factor activity
D0T88_RS20045	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS20055	COG1929	Belongs to the glycerate kinase type-1 family
D0T88_RS20060	COG2084	Dehydrogenase
D0T88_RS20070	COG2271	Major facilitator Superfamily
D0T88_RS20075	COG2721	sulfolactate sulfo-lyase activity
D0T88_RS20080	COG2002	toxin-antitoxin pair type II binding
D0T88_RS20090	COG1349	DNA-binding transcription factor activity
D0T88_RS20100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS20110	COG3716	PTS system mannose fructose sorbose family IID component
D0T88_RS20115	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS20120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0T88_RS20125	COG2222	sugar isomerase
D0T88_RS20135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS20140	COG3715	PTS system
D0T88_RS20145	COG3716	PTS system mannose fructose sorbose family IID component
D0T88_RS20150	COG0363	glucosamine-6-phosphate deaminase activity
D0T88_RS20155	COG3539	Fimbrial protein
D0T88_RS20160	COG3121	Chaperone
D0T88_RS20165	COG3188	usher protein
D0T88_RS20170	COG3539	Fimbrial protein
D0T88_RS20175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0T88_RS20180	COG3107	peptidoglycan biosynthetic process
D0T88_RS20195	COG2823	Periplasmic or secreted lipoprotein
D0T88_RS20200	COG0701	Predicted permease
D0T88_RS20205	COG0702	epimerase
D0T88_RS20210	COG0693	protein deglycase activity
D0T88_RS20225	COG3153	acetyltransferase
D0T88_RS20230	COG3154	lipid carrier protein
D0T88_RS20235	COG0826	peptidase U32
D0T88_RS20240	COG0826	peptidase U32
D0T88_RS20245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0T88_RS20250	COG0814	amino acid
D0T88_RS20255	COG0513	Belongs to the DEAD box helicase family
D0T88_RS20295	COG0195	Participates in both transcription termination and antitermination
D0T88_RS20315	COG2194	sulfuric ester hydrolase activity
D0T88_RS20325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0T88_RS20335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0T88_RS20340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0T88_RS20350	COG1534	Rna-binding protein
D0T88_RS20355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0T88_RS20360	COG2027	D-alanyl-D-alanine carboxypeptidase
D0T88_RS20370	COG0697	spore germination
D0T88_RS20385	COG0142	geranyltranstransferase activity
D0T88_RS20390	COG3423	Transcriptional regulator
D0T88_RS20400	COG5007	Belongs to the BolA IbaG family
D0T88_RS20405	COG3113	response to antibiotic
D0T88_RS20410	COG2854	intermembrane phospholipid transfer
D0T88_RS20415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0T88_RS20420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0T88_RS20425	COG1127	ABC transporter
D0T88_RS20430	COG0530	calcium, potassium:sodium antiporter activity
D0T88_RS20435	COG0517	IMP dehydrogenase activity
D0T88_RS20435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0T88_RS20440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D0T88_RS20445	COG3117	lipopolysaccharide transmembrane transporter activity
D0T88_RS20450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D0T88_RS20455	COG1137	ATPase activity
D0T88_RS20460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D0T88_RS20465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0T88_RS20480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS20485	COG0515	serine threonine protein kinase
D0T88_RS20495	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0T88_RS20500	COG5002	protein histidine kinase activity
D0T88_RS20500	COG0784	Response regulator, receiver
D0T88_RS20500	COG2198	Histidine kinase
D0T88_RS20505	COG1242	4 iron, 4 sulfur cluster binding
D0T88_RS20510	COG0067	glutamate synthase
D0T88_RS20510	COG0070	glutamate synthase
D0T88_RS20510	COG0069	glutamate synthase activity
D0T88_RS20515	COG0493	'glutamate synthase
D0T88_RS20520	COG4804	nuclease activity
D0T88_RS20525	COG2731	YhcH YjgK YiaL family protein
D0T88_RS20555	COG3069	C4-dicarboxylate transmembrane transporter activity
D0T88_RS20560	COG2969	positive regulation of protein catabolic process
D0T88_RS20565	COG0625	glutathione transferase activity
D0T88_RS20580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0T88_RS20585	COG3105	Protein conserved in bacteria
D0T88_RS20590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0T88_RS20595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0T88_RS20615	COG2732	(Barnase) inhibitor
D0T88_RS20635	COG0583	DNA-binding transcription factor activity
D0T88_RS20640	COG0312	modulator of DNA gyrase
D0T88_RS20645	COG3164	Protein of unknown function
D0T88_RS20650	COG1530	ribonuclease E activity
D0T88_RS20660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0T88_RS20665	COG1792	Involved in formation and maintenance of cell shape
D0T88_RS20670	COG1077	Cell shape determining protein MreB Mrl
D0T88_RS20675	COG2199	diguanylate cyclase activity
D0T88_RS20675	COG2200	EAL domain
D0T88_RS20680	COG0604	alcohol dehydrogenase
D0T88_RS20685	COG0511	ligase activity, forming carbon-carbon bonds
D0T88_RS20690	COG0439	Biotin carboxylase
D0T88_RS20695	COG3924	membrane
D0T88_RS20700	COG4145	pantothenate transmembrane transporter activity
D0T88_RS20710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0T88_RS20720	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D0T88_RS20730	COG1309	transcriptional regulator
D0T88_RS20735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS20740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0T88_RS20750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0T88_RS20755	COG4597	amino acid ABC transporter
D0T88_RS20760	COG0765	amino acid transport
D0T88_RS20765	COG1126	abc transporter atp-binding protein
D0T88_RS20805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0T88_RS20825	COG0551	DNA topoisomerase type I activity
D0T88_RS20835	COG0758	DNA mediated transformation
D0T88_RS20855	COG0569	domain protein
D0T88_RS20865	COG3036	rescue of stalled ribosome
D0T88_RS20870	COG0789	Transcriptional regulator
D0T88_RS20910	COG0201	protein transport
D0T88_RS21000	COG0089	rRNA binding
D0T88_RS21070	COG2964	Protein conserved in bacteria
D0T88_RS21075	COG0545	Peptidyl-prolyl cis-trans isomerase
D0T88_RS21085	COG1047	Peptidyl-prolyl cis-trans
D0T88_RS21090	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D0T88_RS21105	COG0488	(ABC) transporter
D0T88_RS21110	COG0429	hydrolase of the alpha beta-hydrolase fold
D0T88_RS21120	COG3954	Phosphoribulokinase
D0T88_RS21125	COG1765	OsmC-like protein
D0T88_RS21130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0T88_RS21135	COG1289	transmembrane transporter activity
D0T88_RS21140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0T88_RS21145	COG0512	Glutamine amidotransferase of anthranilate synthase
D0T88_RS21150	COG2184	nucleotidyltransferase activity
D0T88_RS21160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0T88_RS21170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0T88_RS21175	COG2146	nitrite reductase [NAD(P)H] activity
D0T88_RS21180	COG2116	formate transmembrane transporter activity
D0T88_RS21195	COG0531	amino acid
D0T88_RS21200	COG2222	sugar isomerase
D0T88_RS21205	COG1082	Xylose isomerase domain protein TIM barrel
D0T88_RS21215	COG2188	Transcriptional regulator
D0T88_RS21220	COG0626	cystathionine gamma-synthase activity
D0T88_RS21235	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D0T88_RS21240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D0T88_RS21245	COG3457	Alanine racemase
D0T88_RS21255	COG2188	Transcriptional regulator
D0T88_RS21260	COG0180	Tryptophanyl-tRNA synthetase
D0T88_RS21270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0T88_RS21275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0T88_RS21280	COG3266	domain, Protein
D0T88_RS21295	COG4796	Type ii and iii secretion system protein
D0T88_RS21310	COG3166	PFAM Fimbrial assembly family protein
D0T88_RS21315	COG4972	Pilus assembly protein
D0T88_RS21320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0T88_RS21325	COG0494	nUDIX hydrolase
D0T88_RS21335	COG1011	Hydrolase
D0T88_RS21340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0T88_RS21350	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D0T88_RS21370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0T88_RS21375	COG2183	response to ionizing radiation
D0T88_RS21380	COG1918	ferrous iron import across plasma membrane
D0T88_RS21385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D0T88_RS21395	COG5464	transposase or invertase
D0T88_RS21415	COG2610	gluconate transmembrane transporter activity
D0T88_RS21420	COG1640	4-alpha-glucanotransferase
D0T88_RS21425	COG0058	SHG alpha-glucan phosphorylase activity
D0T88_RS21440	COG1690	Belongs to the RtcB family
D0T88_RS21445	COG4650	regulator
D0T88_RS21450	COG1349	DNA-binding transcription factor activity
D0T88_RS21465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0T88_RS21485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0T88_RS21490	COG0058	SHG alpha-glucan phosphorylase activity
D0T88_RS21515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0T88_RS21520	COG2095	MarC family integral membrane protein
D0T88_RS21530	COG0514	ATP-dependent DNA helicase (RecQ)
D0T88_RS21535	COG2610	gluconate transmembrane transporter activity
D0T88_RS21540	COG3265	gluconokinase activity
D0T88_RS21545	COG1609	Transcriptional regulator
D0T88_RS21550	COG1741	Belongs to the pirin family
D0T88_RS21555	COG0673	inositol 2-dehydrogenase activity
D0T88_RS21560	COG1247	-acetyltransferase
D0T88_RS21565	COG3157	Type VI secretion system effector, Hcp
D0T88_RS21585	COG0405	Gamma-glutamyltransferase
D0T88_RS21595	COG0584	glycerophosphoryl diester phosphodiesterase
D0T88_RS21600	COG3842	ATPase activity
D0T88_RS21610	COG1175	transmembrane transport
D0T88_RS21615	COG1653	transport
D0T88_RS21620	COG0410	ABC transporter
D0T88_RS21625	COG0411	ABC transporter
D0T88_RS21630	COG4177	L-phenylalanine transmembrane transporter activity
D0T88_RS21635	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS21640	COG0683	leucine binding
D0T88_RS21645	COG0456	acetyltransferase
D0T88_RS21650	COG0683	leucine binding
D0T88_RS21655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0T88_RS21660	COG2177	Part of the ABC transporter FtsEX involved in
D0T88_RS21665	COG2884	Cell division ATP-binding protein ftsE
D0T88_RS21670	COG0552	protein localization to endoplasmic reticulum
D0T88_RS21675	COG0742	ribosomal rna small subunit methyltransferase
D0T88_RS21680	COG3776	membrane
D0T88_RS21690	COG3714	YhhN family
D0T88_RS21705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0T88_RS21720	COG0628	permease
D0T88_RS21725	COG2091	lysine biosynthetic process via aminoadipic acid
D0T88_RS21730	COG0747	negative chemotaxis
D0T88_RS21735	COG0601	transmembrane transport
D0T88_RS21740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0T88_RS21745	COG0444	Belongs to the ABC transporter superfamily
D0T88_RS21760	COG2188	Transcriptional regulator
D0T88_RS21770	COG3414	Phosphotransferase system galactitol-specific IIB component
D0T88_RS21775	COG3775	system Galactitol-specific IIC component
D0T88_RS21790	COG0191	fructose-bisphosphate aldolase activity
D0T88_RS21805	COG0842	Transport permease protein
D0T88_RS21810	COG1129	ABC transporter
D0T88_RS21810	COG0842	Transport permease protein
D0T88_RS21815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS21835	COG2081	HI0933 family
D0T88_RS21840	COG0306	phosphate transporter
D0T88_RS21850	COG0589	response to stress
D0T88_RS21855	COG3104	oligopeptide transport
D0T88_RS21865	COG0339	signal peptide processing
D0T88_RS21870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0T88_RS21875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0T88_RS21890	COG0640	Transcriptional regulator
D0T88_RS21895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0T88_RS21900	COG1393	Belongs to the ArsC family
D0T88_RS21920	COG3065	identical protein binding
D0T88_RS21925	COG2197	response regulator
D0T88_RS21930	COG1285	pathogenesis
D0T88_RS21945	COG3247	response to pH
D0T88_RS21950	COG2771	luxR family
D0T88_RS21960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0T88_RS21965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0T88_RS21970	COG2207	Transcriptional regulator
D0T88_RS21980	COG0076	glutamate decarboxylase activity
D0T88_RS21985	COG1858	cytochrome C peroxidase
D0T88_RS21995	COG2197	response regulator
D0T88_RS22000	COG0583	DNA-binding transcription factor activity
D0T88_RS22005	COG1295	ribonuclease BN
D0T88_RS22010	COG0477	Major facilitator Superfamily
D0T88_RS22015	COG2982	Protein involved in outer membrane biogenesis
D0T88_RS22020	COG2200	EAL domain
D0T88_RS22030	COG0612	Peptidase, M16
D0T88_RS22040	COG2199	diguanylate cyclase activity
D0T88_RS22040	COG2200	EAL domain
D0T88_RS22045	COG0457	Tetratricopeptide repeat
D0T88_RS22045	COG3118	belongs to the thioredoxin family
D0T88_RS22050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0T88_RS22055	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS22060	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS22085	COG2194	sulfuric ester hydrolase activity
D0T88_RS22110	COG0814	amino acid
D0T88_RS22115	COG4608	Belongs to the ABC transporter superfamily
D0T88_RS22120	COG0444	Belongs to the ABC transporter superfamily
D0T88_RS22125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0T88_RS22130	COG0601	transmembrane transport
D0T88_RS22135	COG0747	negative chemotaxis
D0T88_RS22145	COG2194	sulfuric ester hydrolase activity
D0T88_RS22175	COG2223	nitrite transmembrane transporter activity
D0T88_RS22180	COG5571	outer membrane autotransporter
D0T88_RS22185	COG2818	Glycosylase
D0T88_RS22190	COG0456	acetyltransferase
D0T88_RS22195	COG0243	molybdopterin cofactor binding
D0T88_RS22200	COG2885	chlorophyll binding
D0T88_RS22215	COG2944	sequence-specific DNA binding
D0T88_RS22220	COG1278	Cold shock
D0T88_RS22245	COG3274	enterobacterial common antigen metabolic process
D0T88_RS22250	COG4682	membrane
D0T88_RS22255	COG4682	membrane
D0T88_RS22260	COG1070	Carbohydrate kinase
D0T88_RS22270	COG4213	ABC transporter substrate-binding protein
D0T88_RS22275	COG1129	ABC transporter
D0T88_RS22280	COG4214	carbohydrate transport
D0T88_RS22285	COG1609	Transcriptional regulator
D0T88_RS22285	COG2207	Transcriptional regulator
D0T88_RS22290	COG2992	FlgJ-related protein
D0T88_RS22295	COG0366	Alpha amylase catalytic
D0T88_RS22300	COG3977	Valine--pyruvate aminotransferase
D0T88_RS22305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0T88_RS22310	COG1414	Transcriptional regulator
D0T88_RS22320	COG2731	YhcH YjgK YiaL family protein
D0T88_RS22325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0T88_RS22330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0T88_RS22335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0T88_RS22340	COG1070	Carbohydrate kinase
D0T88_RS22345	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D0T88_RS22350	COG3623	hexulose-6-phosphate isomerase
D0T88_RS22355	COG0235	Class ii aldolase
D0T88_RS22365	COG3713	MltA-interacting MipA family protein
D0T88_RS22370	COG0583	DNA-binding transcription factor activity
D0T88_RS22375	COG1566	PFAM secretion protein HlyD family protein
D0T88_RS22390	COG1012	belongs to the aldehyde dehydrogenase family
D0T88_RS22395	COG1454	alcohol dehydrogenase
D0T88_RS22400	COG3276	selenocysteine insertion sequence binding
D0T88_RS22410	COG0625	glutathione transferase activity
D0T88_RS22425	COG1413	lyase activity
D0T88_RS22435	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0T88_RS22445	COG1566	PFAM secretion protein HlyD family protein
D0T88_RS22455	COG2213	PTS system mannitol-specific
D0T88_RS22455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS22465	COG3722	fumarate hydratase activity
D0T88_RS22485	COG5295	Hep Hag repeat protein
D0T88_RS22490	COG1620	l-lactate permease
D0T88_RS22495	COG2186	Transcriptional regulator
D0T88_RS22505	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0T88_RS22510	COG1045	serine acetyltransferase
D0T88_RS22525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0T88_RS22530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0T88_RS22540	COG4942	peptidase
D0T88_RS22545	COG2861	carbohydrate metabolic process
D0T88_RS22550	COG1216	Glycosyl transferase, family 2
D0T88_RS22560	COG0156	8-amino-7-oxononanoate synthase activity
D0T88_RS22570	COG0859	PFAM glycosyl transferase family 9
D0T88_RS22575	COG0859	PFAM glycosyl transferase family 9
D0T88_RS22580	COG3307	-O-antigen
D0T88_RS22585	COG1216	Glycosyl transferase, family 2
D0T88_RS22590	COG1442	glycosyl transferase family 8
D0T88_RS22595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0T88_RS22610	COG0515	serine threonine protein kinase
D0T88_RS22615	COG0438	transferase activity, transferring glycosyl groups
D0T88_RS22620	COG0859	PFAM glycosyl transferase family 9
D0T88_RS22625	COG1519	Transferase
D0T88_RS22655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0T88_RS22680	COG1561	YicC-like family, N-terminal region
D0T88_RS22685	COG3645	SOS response
D0T88_RS22690	COG2860	membrane
D0T88_RS22705	COG0194	GDP metabolic process
D0T88_RS22715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0T88_RS22720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0T88_RS22725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0T88_RS22735	COG0786	glutamate:sodium symporter activity
D0T88_RS22740	COG2233	PERMEase
D0T88_RS22750	COG1501	Belongs to the glycosyl hydrolase 31 family
D0T88_RS22755	COG2211	Major facilitator Superfamily
D0T88_RS22765	COG0582	viral genome integration into host DNA
D0T88_RS22825	COG2814	Major facilitator Superfamily
D0T88_RS22830	COG0697	spore germination
D0T88_RS22835	COG1464	Belongs to the NlpA lipoprotein family
D0T88_RS22855	COG2252	PERMEase
D0T88_RS22865	COG2271	Major facilitator Superfamily
D0T88_RS22870	COG2271	Major facilitator Superfamily
D0T88_RS22875	COG3851	Histidine kinase
D0T88_RS22880	COG2197	response regulator
D0T88_RS22885	COG0440	acetolactate synthase activity
D0T88_RS22890	COG0028	Belongs to the TPP enzyme family
D0T88_RS22905	COG2814	Major facilitator Superfamily
D0T88_RS22910	COG0641	radical SAM
D0T88_RS22920	COG2149	membrane
D0T88_RS22930	COG3119	arylsulfatase activity
D0T88_RS22935	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0T88_RS22940	COG2207	Transcriptional regulator
D0T88_RS22955	COG2188	Transcriptional regulator
D0T88_RS22975	COG5645	(Lipo)protein
D0T88_RS22980	COG0823	Involved in the tonB-independent uptake of proteins
D0T88_RS22990	COG2271	Major facilitator Superfamily
D0T88_RS23000	COG0800	Aldolase
D0T88_RS23005	COG3734	2-keto-3-deoxy-galactonokinase
D0T88_RS23010	COG2186	Transcriptional regulator
D0T88_RS23020	COG0561	phosphatase activity
D0T88_RS23025	COG3753	Protein conserved in bacteria
D0T88_RS23030	COG0187	DNA topoisomerase II activity
D0T88_RS23040	COG0592	DNA-directed DNA polymerase activity
D0T88_RS23090	COG0814	amino acid
D0T88_RS23105	COG2091	lysine biosynthetic process via aminoadipic acid
D0T88_RS23110	COG0431	NADPH-dependent FMN reductase
D0T88_RS23115	COG2252	PERMEase
D0T88_RS23120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0T88_RS23130	COG3196	Protein conserved in bacteria
D0T88_RS23135	COG0363	glucosamine-6-phosphate deaminase activity
D0T88_RS23140	COG2382	esterase
D0T88_RS23150	COG2723	6-phospho-beta-galactosidase activity
D0T88_RS23155	COG2190	(PTS) system
D0T88_RS23155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0T88_RS23155	COG1263	PTS System
D0T88_RS23160	COG3711	transcriptional antiterminator
D0T88_RS23165	COG0704	Plays a role in the regulation of phosphate uptake
D0T88_RS23170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0T88_RS23175	COG0581	inorganic phosphate transmembrane transporter activity
D0T88_RS23180	COG0573	inorganic phosphate transmembrane transporter activity
D0T88_RS23185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0T88_RS23195	COG4372	Transposase
D0T88_RS23200	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS23215	COG3188	usher protein
D0T88_RS23230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0T88_RS23280	COG3312	ion transport
D0T88_RS23295	COG0716	FMN binding
D0T88_RS23300	COG1522	sequence-specific DNA binding
D0T88_RS23330	COG1129	ABC transporter
D0T88_RS23335	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0T88_RS23340	COG1879	ABC-type sugar transport system periplasmic component
D0T88_RS23345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS23350	COG1609	Transcriptional regulator
D0T88_RS23355	COG0477	Major facilitator Superfamily
D0T88_RS23360	COG2186	Transcriptional regulator
D0T88_RS23400	COG3085	chromosome segregation
D0T88_RS23405	COG0606	chelatase, subunit chli
D0T88_RS23425	COG3978	acetolactate synthase activity
D0T88_RS23430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0T88_RS23440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0T88_RS23445	COG0583	DNA-binding transcription factor activity
D0T88_RS23455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0T88_RS23460	COG3692	DNA binding
D0T88_RS23465	COG0210	DNA helicase
D0T88_RS23480	COG3118	belongs to the thioredoxin family
D0T88_RS23490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0T88_RS23495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0T88_RS23500	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D0T88_RS23505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0T88_RS23510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0T88_RS23515	COG1088	dTDP-glucose 4,6-dehydratase activity
D0T88_RS23520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0T88_RS23525	COG0456	acetyltransferase
D0T88_RS23530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0T88_RS23535	COG2244	polysaccharide biosynthetic process
D0T88_RS23555	COG1113	amino acid transport
D0T88_RS23580	COG0641	radical SAM
D0T88_RS23585	COG3119	arylsulfatase activity
D0T88_RS23590	COG3071	HemY protein
D0T88_RS23595	COG2959	enzyme of heme biosynthesis
D0T88_RS23600	COG1587	Uroporphyrinogen-III synthase
D0T88_RS23610	COG3072	Adenylate cyclase
D0T88_RS23635	COG5567	small periplasmic lipoprotein
D0T88_RS23645	COG3159	Protein conserved in bacteria
D0T88_RS23655	COG1011	Hydrolase
D0T88_RS23660	COG0210	DNA helicase
D0T88_RS23665	COG3698	Phosphodiester glycosidase
D0T88_RS23670	COG0598	Magnesium transport protein CorA
D0T88_RS23695	COG2962	Rard protein
D0T88_RS23700	COG2050	protein possibly involved in aromatic compounds catabolism
D0T88_RS23705	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D0T88_RS23710	COG0514	ATP-dependent DNA helicase (RecQ)
D0T88_RS23715	COG1280	lysine exporter protein (LysE YggA)
D0T88_RS23720	COG1280	lysine exporter protein (LysE YggA)
D0T88_RS23725	COG2267	carboxylic ester hydrolase activity
D0T88_RS23730	COG0561	phosphatase activity
D0T88_RS23735	COG0697	spore germination
D0T88_RS23740	COG0583	DNA-binding transcription factor activity
D0T88_RS23750	COG0412	Dienelactone hydrolase
D0T88_RS23755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D0T88_RS23760	COG1322	Protein conserved in bacteria
D0T88_RS23770	COG3165	ubiquinone biosynthetic process from chorismate
D0T88_RS23780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0T88_RS23785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0T88_RS23790	COG0805	protein transport
D0T88_RS23800	COG0250	Participates in transcription elongation, termination and antitermination
D0T88_RS23805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0T88_RS23810	COG0543	2 iron, 2 sulfur cluster binding
D0T88_RS23815	COG3547	Transposase (IS116 IS110 IS902 family)
D0T88_RS23835	COG1739	Uncharacterized protein family UPF0029
D0T88_RS23840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0T88_RS23845	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D0T88_RS23875	COG1763	Mo-molybdopterin cofactor biosynthetic process
D0T88_RS23880	COG0746	molybdenum cofactor guanylyltransferase activity
D0T88_RS23885	COG3084	Protein conserved in bacteria
D0T88_RS23890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0T88_RS23895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0T88_RS23900	COG5339	Protein conserved in bacteria
D0T88_RS23905	COG0204	Acyl-transferase
D0T88_RS23910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0T88_RS23910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0T88_RS23925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0T88_RS23935	COG2204	response regulator
D0T88_RS23940	COG3852	Histidine kinase
D0T88_RS23945	COG0174	glutamine synthetase
D0T88_RS23950	COG1217	gtp-binding protein TYPA
D0T88_RS23955	COG2188	Transcriptional regulator
D0T88_RS23960	COG1082	Xylose isomerase domain protein TIM barrel
D0T88_RS23965	COG2271	Major facilitator Superfamily
D0T88_RS23970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0T88_RS23975	COG2211	Major facilitator Superfamily
D0T88_RS23980	COG2211	Major facilitator Superfamily
D0T88_RS23985	COG1501	Belongs to the glycosyl hydrolase 31 family
D0T88_RS23990	COG2017	converts alpha-aldose to the beta-anomer
D0T88_RS23995	COG2942	2-epimerase
D0T88_RS24000	COG3684	Belongs to the aldolase LacD family
D0T88_RS24005	COG2084	Dehydrogenase
D0T88_RS24010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0T88_RS24015	COG1349	DNA-binding transcription factor activity
D0T88_RS24020	COG1011	Hydrolase
D0T88_RS24035	COG0456	acetyltransferase
D0T88_RS24045	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D0T88_RS24055	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0T88_RS24060	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D0T88_RS24070	COG2864	formate dehydrogenase
D0T88_RS24075	COG0437	4 iron, 4 sulfur cluster binding
D0T88_RS24095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS24095	COG3711	transcriptional antiterminator
D0T88_RS24100	COG1363	Peptidase, m42
D0T88_RS24105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS24105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0T88_RS24110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0T88_RS24150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0T88_RS24160	COG2258	MOSC domain
D0T88_RS24165	COG2205	protein histidine kinase activity
D0T88_RS24170	COG0745	RESPONSE REGULATOR receiver
D0T88_RS24175	COG3678	ATP-independent chaperone mediated protein folding
D0T88_RS24190	COG4974	Belongs to the 'phage' integrase family
D0T88_RS24235	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS24240	COG4372	Transposase
D0T88_RS24325	COG1605	Chorismate mutase
D0T88_RS24345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0T88_RS24350	COG1215	transferase activity, transferring glycosyl groups
D0T88_RS24375	COG2207	Transcriptional regulator
D0T88_RS24420	COG2274	protein secretion by the type I secretion system
D0T88_RS24510	COG4372	Transposase
D0T88_RS24515	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS24540	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D0T88_RS24635	COG3436	PFAM IS66 Orf2 family protein
D0T88_RS24640	COG4372	Transposase