locus-tag class description F7D04_RS00065 ENOG410685N tail fiber protein F7D04_RS00070 ENOG4105UZW Tail fiber assembly protein F7D04_RS00105 ENOG4106G8A Qin prophage F7D04_RS00130 ENOG410649Z repressor F7D04_RS00135 ENOG4105W7J DNA binding F7D04_RS00200 ENOG4108MXB Protein of unknown function (DUF968) F7D04_RS00205 ENOG4105KSK (crossover) junction endodeoxyribonuclease F7D04_RS00305 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F7D04_RS00375 ENOG4108X9F tail fiber protein F7D04_RS00380 ENOG4105UZW Tail fiber assembly protein F7D04_RS00390 ENOG4105E3S small subunit F7D04_RS00395 ENOG4105DPX Hydrogenase, large subunit F7D04_RS00400 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit F7D04_RS00405 ENOG4108USZ hydrogenase F7D04_RS00410 ENOG4108VXY Hydrogenase-1 operon protein HyaE F7D04_RS00415 ENOG4105MVP hydrogenase-1 operon protein HyaF F7D04_RS00420 ENOG4105C4M (Ubiquinol oxidase) subunit I F7D04_RS00425 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F7D04_RS00435 ENOG4105D6F Phosphatase F7D04_RS00440 ENOG4105D75 Capsular exopolysaccharide family F7D04_RS00445 ENOG4107ZF2 Phosphatase F7D04_RS00450 ENOG4105DAY polysaccharide export protein F7D04_RS00455 ENOG4105E3R (LipO)protein F7D04_RS00460 ENOG4108W78 Pfam:DUF1017 F7D04_RS00465 ENOG4108Y9B (LipO)protein F7D04_RS00475 ENOG41060EU Cold shock-like protein F7D04_RS00480 ENOG4105VEQ Cold shock protein F7D04_RS00495 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation F7D04_RS00500 ENOG4105HEE Binding Domain protein F7D04_RS00505 ENOG4105BZU Histidine kinase F7D04_RS00510 ENOG4108SV3 Tmao reductase system periplasmic protein tort F7D04_RS00515 ENOG4106WF9 DNA-binding transcriptional regulator TorR F7D04_RS00520 ENOG4105CUW cytochrome C-TYPE protein F7D04_RS00525 ENOG4108J2R molybdopterin oxidoreductase F7D04_RS00550 ENOG4105D6F Phosphatase F7D04_RS00555 ENOG4105XH3 F7D04_RS00565 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 F7D04_RS00570 ENOG4105C2W permease F7D04_RS00605 ENOG4108R86 Transcriptional regulator F7D04_RS00610 ENOG4105C26 Dehydrogenase F7D04_RS00620 ENOG4105CK7 Sodium proline symporter F7D04_RS00630 ENOG410650H (LipO)protein F7D04_RS00640 ENOG4105D5M phosphate starvation-inducible protein F7D04_RS00650 ENOG4105CND Glycosyl transferase, family 2 F7D04_RS00655 ENOG4107BJW polysaccharide deacetylase F7D04_RS00660 ENOG4108TUY outer membrane protein PgaA F7D04_RS00665 ENOG4105BZU Histidine kinase F7D04_RS00680 ENOG4108T85 Membrane F7D04_RS00695 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase F7D04_RS00705 ENOG4107XHZ cytoplasmic chaperone TorD family protein F7D04_RS00710 ENOG4108UQ5 membrane protein YcdZ F7D04_RS00715 ENOG4105P8Q Curli production assembly transport component CsgG F7D04_RS00720 ENOG4108WYR Curli production assembly transport component, CsgF F7D04_RS00725 ENOG4108XDW curli assembly protein CsgE F7D04_RS00730 ENOG41086KC Transcriptional regulator F7D04_RS00735 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers F7D04_RS00740 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin F7D04_RS00755 ENOG4108UVJ appr-1-p processing domain protein F7D04_RS00760 ENOG4107RZC phospholipase d F7D04_RS00775 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) F7D04_RS00780 ENOG4105NAC (LipO)protein F7D04_RS00785 ENOG4108W47 Acidic protein msyB F7D04_RS00795 ENOG4105D1S lipid A biosynthesis F7D04_RS00805 ENOG4108YYC ycei family F7D04_RS00815 ENOG4106974 biofilm formation F7D04_RS00825 ENOG4105PVA Biofilm formation regulatory protein BssS F7D04_RS00830 ENOG4105MEA DNA damage-inducible protein i F7D04_RS00840 ENOG4105F3T (LipO)protein F7D04_RS00845 ENOG4105E9S glutaredoxin 2 F7D04_RS00855 ENOG4105D9U N-acetyltransferase F7D04_RS00865 ENOG4105EP9 oxidoreductase F7D04_RS00870 ENOG4105CJR Integral membrane protein (MviN F7D04_RS00875 ENOG4105QVD Flagella synthesis protein FlgN F7D04_RS00880 ENOG4105M9M anti-sigma28 factor FlgM F7D04_RS00885 ENOG4105CKS Flagella basal body P-ring formation protein flgA F7D04_RS00890 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) F7D04_RS00895 ENOG4108ZC9 flagellar basal-body rod protein flgc F7D04_RS00900 ENOG4105W00 Flagellar hook capping protein F7D04_RS00905 ENOG4105BZE flagellar hook protein, FlgE F7D04_RS00910 ENOG4108KPB Flagellar basal-body rod protein FlgF F7D04_RS00915 ENOG4105CGA flagellar basal-body rod protein FlgG F7D04_RS00930 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj F7D04_RS00935 ENOG4105E1Q flagellar hook-associated protein F7D04_RS00940 ENOG4105DTJ flagellar hook-associated protein F7D04_RS00945 ENOG4107QQB Ribonuclease E F7D04_RS00950 ENOG4105EI2 Pseudouridine synthase F7D04_RS00955 ENOG4108UHJ MAF-like protein F7D04_RS00960 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein F7D04_RS00980 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F7D04_RS00985 ENOG4105CHR reductase F7D04_RS00990 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F7D04_RS00995 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F7D04_RS01000 ENOG4105YAZ 4-amino-4-deoxychorismate lyase F7D04_RS01005 ENOG4105HHA aminodeoxychorismate lyase F7D04_RS01015 ENOG4107QRG dna polymerase iii F7D04_RS01020 ENOG4105F8V Hydrolase, tatD family F7D04_RS01025 ENOG4105CI1 PTS System F7D04_RS01030 ENOG4105CNM Receptor F7D04_RS01035 ENOG4105K59 histidine triad (HIT) protein F7D04_RS01040 ENOG41090DQ Lipoprotein F7D04_RS01045 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) F7D04_RS01050 ENOG4108RUM thiamine kinase F7D04_RS01065 ENOG4105CEP NADH dehydrogenase F7D04_RS01070 ENOG4107MBR 17 kDa surface antigen F7D04_RS01075 ENOG4108IND Tetr family transcriptional regulator F7D04_RS01080 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction F7D04_RS01085 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F7D04_RS01090 ENOG4108JA2 transcriptioN-repair coupling factor F7D04_RS01095 ENOG4105IQC Inner membrane protein YcfT F7D04_RS01100 ENOG4105D60 lipoprotein releasing system transmembrane protein F7D04_RS01105 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) F7D04_RS01110 ENOG4105D60 lipoprotein releasing system transmembrane protein F7D04_RS01120 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) F7D04_RS01135 ENOG4107RUE extracellular solute-binding protein family 1 F7D04_RS01140 ENOG4105D38 putrescine abc transporter F7D04_RS01150 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F7D04_RS01160 ENOG4105EZE Cupin 4 family protein F7D04_RS01165 ENOG4105IFJ Histidine kinase F7D04_RS01170 ENOG4105XJC Two component transcriptional regulator (Winged helix family F7D04_RS01195 ENOG4108R99 pseudouridine synthase F7D04_RS01200 ENOG4108HMX isocitrate dehydrogenase (NADP) F7D04_RS01215 ENOG41064WM Uncharacterized protein YcgX F7D04_RS01220 ENOG4108XDN Transcriptional regulator F7D04_RS01230 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component F7D04_RS01235 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB F7D04_RS01245 ENOG410738I uncharacterized protein ymgC F7D04_RS01250 ENOG4105BZU Histidine kinase F7D04_RS01270 ENOG410658X F7D04_RS01305 ENOG4107QMS site-determining protein F7D04_RS01315 ENOG4105S66 prophage protein F7D04_RS01320 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium F7D04_RS01330 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase F7D04_RS01340 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells F7D04_RS01345 ENOG4105KT5 UmuD protein F7D04_RS01350 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F7D04_RS01355 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) F7D04_RS01370 ENOG4105ED1 spovr family F7D04_RS01380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F7D04_RS01390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F7D04_RS01400 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) F7D04_RS01420 ENOG4105VDH Dihydroxyacetone kinase F7D04_RS01425 ENOG4108UTZ Dihydroxyacetone kinase F7D04_RS01430 ENOG4105CMT Dihydroxyacetone kinase F7D04_RS01435 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F7D04_RS01440 ENOG4105I1J Autotransporter F7D04_RS01445 ENOG4105C3G gtp-binding protein F7D04_RS01455 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria F7D04_RS01460 ENOG4105CHH sulfate transporter F7D04_RS01465 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F7D04_RS01490 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F7D04_RS01495 ENOG4108YY7 Invasion gene expression up-regulator SirB F7D04_RS01500 ENOG41063JG Transcriptional regulator F7D04_RS01520 ENOG4105EWV Sodium calcium exchanger membrane region F7D04_RS01525 ENOG4105WS7 Cation transport regulator F7D04_RS01530 ENOG4108NH8 Cation transport protein F7D04_RS01535 ENOG41090EX DsrE family F7D04_RS01540 ENOG4105ID0 Putative invasin F7D04_RS01545 ENOG4105WH1 Two component transcriptional regulator luxr family F7D04_RS01550 ENOG4105BZU Histidine kinase F7D04_RS01555 ENOG4105DQQ Major facilitator superfamily MFS_1 F7D04_RS01560 ENOG4105CRU nitrate reductase, alpha subunit F7D04_RS01565 ENOG4108IUE nitrate reductase beta subunit F7D04_RS01570 ENOG4105R3A Nitrate reductase F7D04_RS01575 ENOG41076YT nitrate reductase, gamma subunit F7D04_RS01595 ENOG4105CIY formyltetrahydrofolate deformylase F7D04_RS01600 ENOG4105K5B UPF0225 protein F7D04_RS01670 ENOG4105DFP Integrase F7D04_RS01680 ENOG4105D78 K07001 NTE family protein F7D04_RS01685 ENOG4105I93 response regulator F7D04_RS01690 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F7D04_RS01695 ENOG4108SAU DNA-binding protein H-ns F7D04_RS01700 ENOG4107104 thymidine kinase F7D04_RS01705 ENOG4105C0A alcohol dehydrogenase F7D04_RS01710 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein F7D04_RS01720 ENOG4108J59 Extracellular solute-binding protein, family 5 F7D04_RS01725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F7D04_RS01730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F7D04_RS01735 ENOG4105C3U ABC transporter F7D04_RS01740 ENOG4108JQ7 (ABC) transporter F7D04_RS01760 ENOG4107SVH Potassium channel protein F7D04_RS01765 ENOG4105K9H YciI-like protein F7D04_RS01770 ENOG410822N TonB family F7D04_RS01775 ENOG4105NAU thioesterase Superfamily protein F7D04_RS01785 ENOG4108S3I UPF0259 membrane protein F7D04_RS01795 ENOG4105EIF outer membrane protein W F7D04_RS01800 ENOG4108I1J Integrase F7D04_RS01810 ENOG41076J9 exonuclease VIII F7D04_RS01815 ENOG4106G8A Qin prophage F7D04_RS01870 ENOG4105JBR DNA replication protein F7D04_RS01905 ENOG4108MXB Protein of unknown function (DUF968) F7D04_RS01910 ENOG4105KSK (crossover) junction endodeoxyribonuclease F7D04_RS01915 ENOG4105HRS Antitermination protein F7D04_RS02000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F7D04_RS02075 ENOG4108X9F tail fiber protein F7D04_RS02080 ENOG4105UZW Tail fiber assembly protein F7D04_RS02090 ENOG4108N8X transition metal ion binding F7D04_RS02095 ENOG4108Z9Z response to DNA damage stimulus F7D04_RS02105 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) F7D04_RS02115 ENOG4105DK0 Indole-3-glycerol phosphate synthase F7D04_RS02120 ENOG4108EFP Anthranilate synthase component II F7D04_RS02125 ENOG4105CRQ synthase (Component I) F7D04_RS02135 ENOG4105DB7 PHP domain protein F7D04_RS02140 ENOG4107RTD sua5 ycio yrdc ywlc family protein F7D04_RS02145 ENOG4105EG3 transmembrane signal peptide protein F7D04_RS02150 ENOG4105FE9 pseudouridine synthase F7D04_RS02155 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase F7D04_RS02160 ENOG4105UBK short-chain dehydrogenase reductase F7D04_RS02165 ENOG4105ERU peptidase F7D04_RS02170 ENOG4105RKX Protein of unknown function (DUF2498) F7D04_RS02175 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F7D04_RS02180 ENOG4107R11 Transcriptional regulator F7D04_RS02200 ENOG4107QM5 aconitate hydratase F7D04_RS02210 ENOG4105EYK Phosphatidylglycerophosphatase B F7D04_RS02215 ENOG4105Q4A inner membrane protein yciS F7D04_RS02220 ENOG4105CFV Tetratricopeptide repeat protein F7D04_RS02230 ENOG4108ZJT translation initiation factor, Sui1 F7D04_RS02240 ENOG4105N2W Transcriptional regulator F7D04_RS02245 ENOG410643D UPF0509 protein F7D04_RS02250 ENOG4105BZU Histidine kinase F7D04_RS02265 ENOG4105Q4T oxidoreductase F7D04_RS02270 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH F7D04_RS02275 ENOG4105WDY DNA (cytosine-5-)-methyltransferase F7D04_RS02280 ENOG4108JQ2 peptide transport system atp-binding protein F7D04_RS02285 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein F7D04_RS02290 ENOG4108EU3 peptide transport system, permease F7D04_RS02295 ENOG4108I5W peptide transport system, permease protein F7D04_RS02300 ENOG4108HIY periplasmic F7D04_RS02305 ENOG4105N0E Protein of unknown function (DUF2543) F7D04_RS02310 ENOG4105CUB amino acid F7D04_RS02320 ENOG4105CFQ glutamine synthetase F7D04_RS02325 ENOG4108Z86 Glutamine amidotransferase F7D04_RS02330 ENOG4107VRI Transcriptional regulator F7D04_RS02335 ENOG4105C26 Dehydrogenase F7D04_RS02340 ENOG4105CJP fad dependent oxidoreductase F7D04_RS02345 ENOG4108JPW Aminotransferase F7D04_RS02350 ENOG4105E51 psp operon transcriptional activator F7D04_RS02355 ENOG41087YS Phage shock protein A F7D04_RS02360 ENOG4105YYT phage shock protein B F7D04_RS02365 ENOG4105FM1 phage shock protein C F7D04_RS02370 ENOG4105NNG Peripheral inner membrane phage-shock protein F7D04_RS02375 ENOG4105K8Z Phage shock protein F7D04_RS02380 ENOG4107QW3 Sucrose phosphorylase F7D04_RS02385 ENOG4105WEM extracellular solute-binding protein F7D04_RS02390 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component F7D04_RS02395 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component F7D04_RS02400 ENOG4107RRD Dehydrogenase F7D04_RS02405 ENOG4107TYA transient receptor potential locus F7D04_RS02410 ENOG4105CK5 oxidoreductase F7D04_RS02415 ENOG4105C71 hydrolase family 65, central catalytic F7D04_RS02420 ENOG4107URF beta-phospho-glucomutase F7D04_RS02425 ENOG4108IJ9 (ABC) transporter F7D04_RS02430 ENOG4107EFV Outer membrane protein G F7D04_RS02435 ENOG4105FKQ transcriptional regulator F7D04_RS02440 ENOG4105CM6 amino acid regulated cytosolic protein F7D04_RS02450 ENOG4108JU8 Transcriptional regulator F7D04_RS02455 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) F7D04_RS02460 ENOG4107S8C mandelate racemase muconate lactonizing F7D04_RS02465 ENOG4105KXI murein peptide amidase A F7D04_RS02480 ENOG4105ENX hydrolase F7D04_RS02485 ENOG4105EQ2 LysR family Transcriptional regulator F7D04_RS02490 ENOG4107QSI ABC, transporter F7D04_RS02495 ENOG4105D64 Mechanosensitive ion channel F7D04_RS02500 ENOG4105S5I Membrane F7D04_RS02505 ENOG4105Q9Y Universal stress protein F7D04_RS02510 ENOG4105DS0 Transcriptional regulator, Crp Fnr family F7D04_RS02515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F7D04_RS02520 ENOG4105CFC Transporter F7D04_RS02525 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B F7D04_RS02530 ENOG4105CH2 amidohydrolase F7D04_RS02535 ENOG4106KR7 LysR family Transcriptional regulator F7D04_RS02540 ENOG4108DG9 Smr protein MutS2 F7D04_RS02545 ENOG4105BZU Histidine kinase F7D04_RS02555 ENOG4105C1J atp-dependent rna helicase F7D04_RS02565 ENOG4107R08 Integrase F7D04_RS02570 ENOG4107160 Rac prophage F7D04_RS02575 ENOG41070YT Rac prophage F7D04_RS02580 ENOG4106YAH restriction alleviation and modification enhancement F7D04_RS02590 ENOG41076J9 exonuclease VIII F7D04_RS02600 ENOG4107C82 Rac prophage F7D04_RS02630 ENOG4105ZTP Protein of unknown function (DUF1376) F7D04_RS02635 ENOG4105JBR DNA replication protein F7D04_RS02685 ENOG4105RWQ Protein of unknown function (DUF1364) F7D04_RS02735 ENOG4108ES9 ParB domain protein nuclease F7D04_RS02895 ENOG4108RW8 Universal stress protein F F7D04_RS02900 ENOG4105FCK Membrane F7D04_RS02905 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) F7D04_RS02910 ENOG4105IKK cytoplasmic protein F7D04_RS02915 ENOG41090X5 Heat shock protein hslJ F7D04_RS02920 ENOG4105C5I Dehydrogenase F7D04_RS02925 ENOG4107H52 Dicarboxylate transport F7D04_RS02930 ENOG410689M (LipO)protein F7D04_RS02935 ENOG4105WXT Conserved Protein F7D04_RS02940 ENOG4108WFR AraC Family Transcriptional Regulator F7D04_RS02945 ENOG4105C26 Dehydrogenase F7D04_RS02950 ENOG4105F11 amine oxidase F7D04_RS02955 ENOG4105DXM phenylacetic acid degradation protein F7D04_RS02960 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit F7D04_RS02965 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit F7D04_RS02970 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit F7D04_RS02975 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit F7D04_RS02980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F7D04_RS02985 ENOG4105E39 Enoyl-CoA hydratase F7D04_RS02990 ENOG4108UKI Enoyl-CoA hydratase F7D04_RS02995 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F7D04_RS03000 ENOG4108ZJI phenylacetic acid degradation protein F7D04_RS03005 ENOG4105CHU acetyl-coa acetyltransferase F7D04_RS03010 ENOG4105DZS Phenylacetate-CoA ligase F7D04_RS03015 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein F7D04_RS03020 ENOG4108Z0R Transferase F7D04_RS03025 ENOG4107S5I aldo keto reductase F7D04_RS03035 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase F7D04_RS03040 ENOG4108HPI phosphatidate Cytidylyltransferase F7D04_RS03045 ENOG4105E8V Alpha Beta Hydrolase Fold protein F7D04_RS03050 ENOG41077RS Phosphatase F7D04_RS03060 ENOG4105CQ7 ATP-dependent helicase F7D04_RS03065 ENOG4107DB1 DUF218 domain F7D04_RS03070 ENOG4105C26 Dehydrogenase F7D04_RS03075 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F7D04_RS03080 ENOG4105CPW cytochrome b561 F7D04_RS03085 ENOG4105UPP uncharacterized protein ydcA F7D04_RS03090 ENOG4107NK6 Hok/gef family F7D04_RS03095 ENOG4105C8Q Methyl-accepting chemotaxis F7D04_RS03120 ENOG4105E32 cytoplasmic protein F7D04_RS03130 ENOG4105Z2P Protein of unknown function (DUF465) F7D04_RS03135 ENOG4108Z9I -acetyltransferase F7D04_RS03140 ENOG4107WE3 acetyltransferase YdcK F7D04_RS03145 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein F7D04_RS03150 ENOG41088CC tellurite resistance protein tehB F7D04_RS03155 ENOG4108KKZ (LipO)protein F7D04_RS03165 ENOG4105D7V transposase F7D04_RS03170 ENOG4105DKK Benzoate F7D04_RS03175 ENOG4108JCI Transcriptional regulator F7D04_RS03180 ENOG4105CFP Peptidase U32 F7D04_RS03185 ENOG4105RR0 Protein of unknown function (DUF2554) F7D04_RS03195 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin F7D04_RS03200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F7D04_RS03205 ENOG4107TYH extracellular solute-binding protein family 1 F7D04_RS03210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F7D04_RS03215 ENOG4105D81 ABC transporter, permease F7D04_RS03220 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component F7D04_RS03235 ENOG410654E Membrane F7D04_RS03240 ENOG4105R71 cytoplasmic protein F7D04_RS03245 ENOG4108T9Y Inner membrane protein ydcZ F7D04_RS03250 ENOG4108Z7F N-acetyltransferase F7D04_RS03255 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein F7D04_RS03260 ENOG4108WYP Transcriptional regulator F7D04_RS03265 ENOG4105CHB tonB-dependent Receptor F7D04_RS03270 ENOG4108NS2 receptor F7D04_RS03275 ENOG4105C85 amino acid F7D04_RS03280 ENOG4108N27 Glutathione S-transferase F7D04_RS03290 ENOG4105CS6 Rhs element vgr protein F7D04_RS03300 ENOG4108MEJ flavin reductase domain protein F7D04_RS03305 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F7D04_RS03310 ENOG4105JAB phenazine biosynthesis protein, phzf family F7D04_RS03315 ENOG4105D0D Nitrate reductase 2, gamma subunit F7D04_RS03320 ENOG4108NZN Respiratory nitrate reductase 2 delta chain F7D04_RS03325 ENOG4108IUE nitrate reductase beta subunit F7D04_RS03330 ENOG4105CRU nitrate reductase, alpha subunit F7D04_RS03335 ENOG4107QND Nitrite extrusion protein F7D04_RS03350 ENOG4105RPH Inner membrane protein YddG F7D04_RS03360 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F7D04_RS03365 ENOG4108MG3 formate dehydrogenase F7D04_RS03370 ENOG41084S7 Plasmid maintenance system antidote protein F7D04_RS03375 ENOG4105DQ4 alcohol dehydrogenase F7D04_RS03380 ENOG4107R1I NAD-dependent malic enzyme F7D04_RS03385 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein F7D04_RS03390 ENOG4105TPS biofilm-dependent modulation protein F7D04_RS03395 ENOG4108Z9K Osmotically inducible protein F7D04_RS03400 ENOG4107H6U ABC transporter F7D04_RS03405 ENOG4105C3U ABC transporter F7D04_RS03410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F7D04_RS03415 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F7D04_RS03420 ENOG4105DEF Extracellular solute-binding protein, family 5 F7D04_RS03425 ENOG4108UQS dipeptidase F7D04_RS03430 ENOG4105BZU Histidine kinase F7D04_RS03440 ENOG4105F32 YngK protein F7D04_RS03445 ENOG4105E5D amino acid F7D04_RS03450 ENOG4105CVK Glutamate decarboxylase F7D04_RS03455 ENOG4107RAN Peptidase, M16 F7D04_RS03460 ENOG4105PE1 Receptor F7D04_RS03465 ENOG4105CQ0 ABC transporter F7D04_RS03475 ENOG4105C4X radical SAM domain protein F7D04_RS03480 ENOG4105ENH Sulfatase F7D04_RS03485 ENOG4108NKV transcriptional regulator F7D04_RS03500 ENOG4106318 fimbrial-like protein YdeR F7D04_RS03525 ENOG4105C2J ABC transporter F7D04_RS03550 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound F7D04_RS03555 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) F7D04_RS03560 ENOG4105FFC UPF0187 protein F7D04_RS03570 ENOG4105BZU Histidine kinase F7D04_RS03575 ENOG4105M0C cytoplasmic protein F7D04_RS03580 ENOG4105CSV Glutaminase F7D04_RS03585 ENOG4105C26 Dehydrogenase F7D04_RS03590 ENOG4105EGI Transcriptional regulator F7D04_RS03620 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes F7D04_RS03625 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF F7D04_RS03630 ENOG4106DNR multiple antibiotic resistance protein F7D04_RS03635 ENOG4108594 Permease of the drug metabolite transporter F7D04_RS03640 ENOG4105E5W Transporter F7D04_RS03650 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria F7D04_RS03655 ENOG4108YDI single-species biofilm formation on inanimate substrate F7D04_RS03660 ENOG4108WTK competence damage-inducible protein F7D04_RS03665 ENOG4105DGW oligopeptidase A F7D04_RS03670 ENOG4105EMU Dehydrogenase F7D04_RS03675 ENOG4107XBN GntR Family Transcriptional Regulator F7D04_RS03680 ENOG41061EV selenium-binding protein YdfZ F7D04_RS03685 ENOG4105DEI Mannitol dehydrogenase F7D04_RS03700 ENOG4105DIK (ABC) transporter F7D04_RS03705 ENOG4105CC5 ABC transporter F7D04_RS03710 ENOG4105CC5 ABC transporter F7D04_RS03810 ENOG4105IM0 capsid protein F7D04_RS03835 ENOG4105UZW Tail fiber assembly protein F7D04_RS03840 ENOG4105FKG DNA packaging protein F7D04_RS03845 ENOG4106YSC F7D04_RS03870 ENOG4105QFS Lysis protein S homolog from lambdoid prophage F7D04_RS03890 ENOG4105HRS Antitermination protein F7D04_RS03895 ENOG4105KSK (crossover) junction endodeoxyribonuclease F7D04_RS03900 ENOG4108MXB Protein of unknown function (DUF968) F7D04_RS03915 ENOG4105WI6 cell killing protein encoded within cryptic prophage F7D04_RS03950 ENOG41087BU transcriptional repressor DicA F7D04_RS03975 ENOG4106G8A Qin prophage F7D04_RS03990 ENOG4107R08 Integrase F7D04_RS04000 ENOG4105CPQ Dehydrogenase F7D04_RS04005 ENOG4105CXK mandelate racemase muconate lactonizing F7D04_RS04020 ENOG4108MK9 spermidine N(1)-acetyltransferase F7D04_RS04025 ENOG4105D69 UPF0257 lipoprotein ynfC F7D04_RS04030 ENOG4105KBG Protein of unknown function (DUF1161) F7D04_RS04035 ENOG4107QY8 reductase F7D04_RS04040 ENOG4105C3J Cysteine desulfurase F7D04_RS04045 ENOG4105QAX Iron-sulfur F7D04_RS04050 ENOG4107KGK dmso reductase anchor subunit F7D04_RS04055 ENOG4108NEM leader-binding protein dmsD F7D04_RS04080 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F7D04_RS04085 ENOG4105DAG ROK family F7D04_RS04090 ENOG4106NZI LysR family Transcriptional regulator F7D04_RS04095 ENOG4105D94 Major Facilitator Superfamily F7D04_RS04110 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap F7D04_RS04125 ENOG4105DSF transport protein F7D04_RS04130 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F7D04_RS04135 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F7D04_RS04140 ENOG4105C5D exported protein F7D04_RS04145 ENOG4105D5Q Arginine ornithine antiporter F7D04_RS04155 ENOG4105RA2 Membrane F7D04_RS04160 ENOG4107EXC regulatoR F7D04_RS04165 ENOG4105JJR Histidine kinase F7D04_RS04175 ENOG4105C9Q fumarate hydratase class II F7D04_RS04180 ENOG4107GFK fumarate F7D04_RS04185 ENOG4105EIP mannose-6-phosphate isomerase F7D04_RS04190 ENOG4106J39 exported protein F7D04_RS04195 ENOG4108QNI outer membrane porin protein F7D04_RS04200 ENOG4105CT4 transporter F7D04_RS04205 ENOG4105CNT hydrolase family 2 F7D04_RS04210 ENOG4105XEA Tetr family transcriptional regulator F7D04_RS04215 ENOG4107ZQV short-chain dehydrogenase reductase F7D04_RS04220 ENOG4107P2S Transcriptional regulator F7D04_RS04225 ENOG4105CI1 PTS System F7D04_RS04230 ENOG4105C87 Aminotransferase class I and II F7D04_RS04245 ENOG4106C6R beta-lactam resistance protein F7D04_RS04250 ENOG4105QZ5 OriC-binding nucleoid-associated protein F7D04_RS04255 ENOG4105M9B inner membrane protein ydgK F7D04_RS04280 ENOG4108UQQ Electron transport complex F7D04_RS04290 ENOG4105CSM endonuclease III F7D04_RS04295 ENOG4105DUX Transporter F7D04_RS04300 ENOG4108K3A Glutathione S-transferase F7D04_RS04305 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) F7D04_RS04320 ENOG410642K Lysozyme inhibitor F7D04_RS04330 ENOG4108XTF Outer Membrane Lipoprotein F7D04_RS04345 ENOG4105Y49 secretion protein, HlyD family F7D04_RS04350 ENOG4105DSW Fusaric acid resistance protein F7D04_RS04355 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F7D04_RS04360 ENOG4107RGM aldo keto reductase F7D04_RS04365 ENOG4105XZD Fe-S protein F7D04_RS04370 ENOG4108WUH Transcriptional regulator, TetR family F7D04_RS04375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F7D04_RS04380 ENOG4108UYE Lactoylglutathione lyase F7D04_RS04390 ENOG4107QRT dEAD DEAH box helicase F7D04_RS04395 ENOG4105M2J Glutaredoxin F7D04_RS04400 ENOG4105K4H Nlp p60 protein F7D04_RS04405 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F7D04_RS04410 ENOG4105F27 Major Facilitator F7D04_RS04425 ENOG4105F52 Transcriptional regulator F7D04_RS04430 ENOG4105CZQ inner membrane transport protein YdhC F7D04_RS04435 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F7D04_RS04440 ENOG4108R6K riboflavin synthase, subunit alpha F7D04_RS04465 ENOG4105N0V mono-oxygenase ydhR F7D04_RS04470 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain F7D04_RS04475 ENOG4108Y7C Conserved Protein F7D04_RS04480 ENOG4108NWD Cytochrome F7D04_RS04485 ENOG4108393 oxidoreductase Fe-S subunit F7D04_RS04490 ENOG4105JVW F7D04_RS04495 ENOG4105WE2 aldehyde ferredoxin oxidoreductase F7D04_RS04505 ENOG4105RFR Protein of unknown function (DUF2767) F7D04_RS04510 ENOG4105CA9 Pyruvate kinase F7D04_RS04515 ENOG4105KMX major outer membrane lipoprotein F7D04_RS04520 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F7D04_RS04535 ENOG4105JRK feS assembly protein SufD F7D04_RS04540 ENOG4105C3K feS assembly ATPase SufC F7D04_RS04545 ENOG4105DIW FeS assembly protein SUFB F7D04_RS04550 ENOG4108Z4V iron-sulfur cluster assembly F7D04_RS04555 ENOG410671Z uncharacterized protein ydiH F7D04_RS04560 ENOG4105KA0 thioesterase Superfamily protein F7D04_RS04565 ENOG4105CQB FAD linked oxidase domain protein F7D04_RS04570 ENOG4105IPI Membrane F7D04_RS04580 ENOG4105SUA Ydil protein F7D04_RS04585 ENOG4105EMV Major Facilitator F7D04_RS04590 ENOG4105EMV Major Facilitator F7D04_RS04605 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) F7D04_RS04610 ENOG4105C1G acyl-Coa dehydrogenase F7D04_RS04615 ENOG4105W4W Transcriptional regulator F7D04_RS04620 ENOG4105CV7 Electron transfer flavoprotein F7D04_RS04625 ENOG4105C10 Electron transfer flavoprotein F7D04_RS04630 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase F7D04_RS04635 ENOG41090P5 ferredoxin-like protein F7D04_RS04640 ENOG4105CEY Amp-dependent synthetase and ligase F7D04_RS04645 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F7D04_RS04655 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F7D04_RS04670 ENOG4108TC0 Diguanylate phosphodiesterase F7D04_RS04675 ENOG4108QBX (LipO)protein F7D04_RS04685 ENOG4108V06 Glutathione peroxidase F7D04_RS04720 ENOG41082NX 50s ribosomal protein l35 F7D04_RS04725 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F7D04_RS04745 ENOG4108NE3 Salt-induced outer membrane protein F7D04_RS04750 ENOG4105DE4 1-phosphofructokinase F7D04_RS04755 ENOG4105P10 Uncharacterized protein ydiZ F7D04_RS04765 ENOG4107PN8 YfeABCD locus regulator F7D04_RS04770 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 F7D04_RS04775 ENOG4107K5X Membrane-bound metal-dependent hydrolase F7D04_RS04780 ENOG4108ETY sodium dicarboxylate symporter F7D04_RS04795 ENOG4105CH6 catalase F7D04_RS04805 ENOG4105F8D glycoside hydrolase family 4 F7D04_RS04810 ENOG4105EZV Transcriptional regulator F7D04_RS04815 ENOG4105VCP PTS System F7D04_RS04820 ENOG4105CK1 PTS System F7D04_RS04825 ENOG4105VZJ PTS System F7D04_RS04830 ENOG4105KKI DNA-binding transcriptional activator OsmE F7D04_RS04840 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) F7D04_RS04850 ENOG4108SPG Periplasmic Protein F7D04_RS04880 ENOG4105CGK Exodeoxyribonuclease III F7D04_RS04885 ENOG4108RSN SNARE associated Golgi F7D04_RS04890 ENOG4108KCW iron-sulfur cluster binding F7D04_RS04895 ENOG4108N5C SNARE associated Golgi protein-related protein F7D04_RS04900 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F7D04_RS04905 ENOG4105VNH ABC transporter solute-binding protein F7D04_RS04910 ENOG4105CXZ ABC transporter, permease F7D04_RS04915 ENOG4108VGW abc transporter atp-binding protein F7D04_RS04920 ENOG4107RM6 sulfurtransferase F7D04_RS04925 ENOG4108T9J Cdp-alcohol phosphatidyltransferase F7D04_RS04930 ENOG4105M6F mutator MutT protein F7D04_RS04935 ENOG4105MTM Protein of unknown function (DUF1496) F7D04_RS04940 ENOG4105D82 Glutamate dehydrogenase F7D04_RS04945 ENOG41065FB inner membrane protein ynji F7D04_RS04950 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F7D04_RS04960 ENOG41069NU Nitroreductase F7D04_RS04965 ENOG4105D07 Signal peptide peptidase, SppA F7D04_RS04970 ENOG4105HDK L-asparaginase F7D04_RS04975 ENOG4108RWI nicotinamidase F7D04_RS04980 ENOG4105VUT cytoplasmic protein F7D04_RS04990 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F7D04_RS04995 ENOG4105DSB aldose 1-epimerase F7D04_RS05000 ENOG4105CV8 reductase F7D04_RS05005 ENOG4105GNX MltA-interacting MipA family protein F7D04_RS05010 ENOG4105CYN Serine protein kinase F7D04_RS05020 ENOG4106KTS Inner membrane protein yeaI F7D04_RS05025 ENOG4108KHP Diguanylate cyclase F7D04_RS05030 ENOG4108KXH Ybak prolyl-tRNA synthetase associated F7D04_RS05045 ENOG4105R1U AraC Family Transcriptional Regulator F7D04_RS05050 ENOG4105DJ2 Major Facilitator Superfamily F7D04_RS05055 ENOG4105K78 MarR family Transcriptional regulator F7D04_RS05060 ENOG4105UCG Domain of unknown function (DUF333) F7D04_RS05065 ENOG410620I Diguanylate cyclase F7D04_RS05070 ENOG4106G4W F7D04_RS05080 ENOG4105Y3U Transglycosylase-associated protein F7D04_RS05085 ENOG4105D7V transposase F7D04_RS05090 ENOG4108RS6 transposase F7D04_RS05095 ENOG4105YP6 Domain of unknown function (DUF1869) F7D04_RS05100 ENOG4108YS1 cytoplasmic protein F7D04_RS05110 ENOG4105EJC lysr family transcriptional regulator F7D04_RS05115 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F7D04_RS05120 ENOG4105C94 Transporter F7D04_RS05125 ENOG4105DVW rieske (2Fe-2S) F7D04_RS05130 ENOG4105E3J oxidoreductase F7D04_RS05135 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) F7D04_RS05140 ENOG4105CEY Amp-dependent synthetase and ligase F7D04_RS05145 ENOG4105Y4Z Outer Membrane Lipoprotein F7D04_RS05150 ENOG41072GX Peptidase M22 Glycoprotease F7D04_RS05155 ENOG4105DVT helicase F7D04_RS05160 ENOG4105M4H endoribonuclease L-psp F7D04_RS05165 ENOG4105V2F Uncharacterized protein yoac F7D04_RS05175 ENOG4105CRQ synthase (Component I) F7D04_RS05185 ENOG4105EJQ L-serine dehydratase F7D04_RS05190 ENOG4107XTP (EAL) domain protein F7D04_RS05195 ENOG4105EE5 Membrane protein terC F7D04_RS05200 ENOG4105DAS pts system F7D04_RS05205 ENOG4105ETZ PTS System F7D04_RS05210 ENOG4105F3R pts system mannose fructose sorbose family iid F7D04_RS05225 ENOG4105DHI Methyltransferase F7D04_RS05240 ENOG4105Q3Y exported protein F7D04_RS05250 ENOG4105TIK F7D04_RS05255 ENOG4105J4Q Transcriptional regulator F7D04_RS05260 ENOG4105C0R drug resistance transporter emrb qaca subfamily F7D04_RS05270 ENOG4105CN1 protease F7D04_RS05280 ENOG4108ZGC gaf domain protein F7D04_RS05285 ENOG4105H2K paraquat-inducible protein a F7D04_RS05290 ENOG4105DY2 Paraquat-inducible protein b F7D04_RS05300 ENOG4105WT8 Protein of unknown function (DUF1480) F7D04_RS05305 ENOG4105UVW uncharacterized protein yebW F7D04_RS05310 ENOG4108R1E Serine threonine protein phosphatase 1 F7D04_RS05315 ENOG4105NKT exported protein F7D04_RS05320 ENOG4108PNC copper resistance F7D04_RS05325 ENOG4105FXM Copper resistance protein F7D04_RS05330 ENOG4105MPK DNA polymerase III subunit theta F7D04_RS05335 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F7D04_RS05340 ENOG4105UMD exodeoxyribonuclease X F7D04_RS05345 ENOG4105CUG Oligopeptidase b F7D04_RS05350 ENOG4108Q2J Inner membrane protein YebE F7D04_RS05360 ENOG4105X2V dna damage-inducible protein F7D04_RS05370 ENOG4108UHU Aldolase F7D04_RS05375 ENOG4105C01 Dihydroxy-acid dehydratase F7D04_RS05380 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F7D04_RS05385 ENOG4106KNT transcriptional regulator F7D04_RS05390 ENOG4105CA9 Pyruvate kinase F7D04_RS05395 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase F7D04_RS05400 ENOG4105DR5 peptidase F7D04_RS05405 ENOG4105NXV High-affinity zinc uptake system protein F7D04_RS05415 ENOG4105FAV ABC, transporter F7D04_RS05435 ENOG4107S01 Repressor protein MetJ F7D04_RS05445 ENOG4105CDY transcriptional regulatory protein F7D04_RS05450 ENOG4108TIT dATP pyrophosphohydrolase F7D04_RS05460 ENOG4105D3W isochorismatase F7D04_RS05465 ENOG4106FE3 DNA repair F7D04_RS05475 ENOG4108X9F tail fiber protein F7D04_RS05550 ENOG4105IM0 capsid protein F7D04_RS05575 ENOG4105UZW Tail fiber assembly protein F7D04_RS05585 ENOG4106YSC F7D04_RS05590 ENOG4105QYK bacteriophage lambda Bor protein homolog F7D04_RS05600 ENOG4105KUS lysozyme F7D04_RS05605 ENOG4105QFS Lysis protein S homolog from lambdoid prophage F7D04_RS05635 ENOG4105HRS Antitermination protein F7D04_RS05670 ENOG4105NY2 NinB protein F7D04_RS05750 ENOG4108PNI recT protein F7D04_RS05785 ENOG41077V0 CPS-53 (KpLE1) prophage F7D04_RS05820 ENOG4107R08 Integrase F7D04_RS05825 ENOG41081XQ Conserved Protein F7D04_RS05830 ENOG4105WJG Glutathione F7D04_RS05845 ENOG4108J2R molybdopterin oxidoreductase F7D04_RS05850 ENOG4105CUW cytochrome C-TYPE protein F7D04_RS05860 ENOG4106ZCM YecM protein F7D04_RS05875 ENOG4105W13 flagellar protein F7D04_RS05880 ENOG4105D7B Flagellar biosynthesis protein flha F7D04_RS05885 ENOG4105D00 flagellar biosynthetic protein flhB F7D04_RS05890 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) F7D04_RS05895 ENOG4108VYJ response regulator receiver protein F7D04_RS05900 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) F7D04_RS05905 ENOG4105BZU Histidine kinase F7D04_RS05910 ENOG4105C8Q Methyl-accepting chemotaxis F7D04_RS05915 ENOG4105C8Q Methyl-accepting chemotaxis F7D04_RS05920 ENOG4108V3W Chemotaxis protein, CheW F7D04_RS05925 ENOG4105CBS Chea signal transduction histidine kinase F7D04_RS05930 ENOG4105ER2 Ompa motb domain protein F7D04_RS05935 ENOG4107RD7 Flagellar Motor Protein, MotA F7D04_RS05940 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region F7D04_RS05950 ENOG4108VA4 Universal stress protein F7D04_RS05960 ENOG4108K4C ec 3.1.3.12 F7D04_RS05965 ENOG4105CNN ABC, transporter F7D04_RS05970 ENOG4105C2J ABC transporter F7D04_RS05975 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator F7D04_RS05980 ENOG4108UEC Ferritin-like protein F7D04_RS05985 ENOG4105N4N Protein of unknown function (DUF2766) F7D04_RS05995 ENOG4105P23 (LipO)protein F7D04_RS06000 ENOG41090A1 ferritin F7D04_RS06005 ENOG4105VVZ metal-binding protein F7D04_RS06010 ENOG4105E0U tyrosine-specific transport protein F7D04_RS06015 ENOG4106RHG Yeca family F7D04_RS06020 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F7D04_RS06100 ENOG4105VZ1 Replication Protein F7D04_RS06125 ENOG4105ED4 portal protein F7D04_RS06205 ENOG4108X9F tail fiber protein F7D04_RS06210 ENOG4105UZW Tail fiber assembly protein F7D04_RS06220 ENOG4108C33 Resolvase F7D04_RS06300 ENOG4105WH1 Two component transcriptional regulator luxr family F7D04_RS06310 ENOG4105XVG cytoplasmic protein F7D04_RS06315 ENOG4105VJY transcriptional regulator F7D04_RS06320 ENOG4105CDA abc transporter atp-binding protein F7D04_RS06325 ENOG4105E5Q amino acid AbC transporter F7D04_RS06330 ENOG4105K6H D-cysteine desulfhydrase F7D04_RS06335 ENOG4105EAB amino acid AbC transporter F7D04_RS06340 ENOG4108M9K flagella biosynthesis protein FliZ F7D04_RS06345 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F7D04_RS06355 ENOG4105DTS flagellar hook-associated F7D04_RS06360 ENOG4105MQ3 flagellar protein FliS F7D04_RS06370 ENOG4105E5K Alpha-amylase F7D04_RS06375 ENOG4108W9D (LipO)protein F7D04_RS06380 ENOG41066VF YeeE YedE family protein F7D04_RS06390 ENOG4108RAV Conserved protein F7D04_RS06400 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) F7D04_RS06405 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F7D04_RS06410 ENOG41090PJ Flagellar assembly protein F7D04_RS06415 ENOG4108JIR Flagellum-specific ATP synthase F7D04_RS06420 ENOG4105GSA Flagellar export protein flij F7D04_RS06425 ENOG4105WF4 Flagellar hook-length control protein F7D04_RS06430 ENOG4107ZI8 flagellar basal body-associated protein flil F7D04_RS06435 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F7D04_RS06440 ENOG4105DD5 Flagellar motor switch protein F7D04_RS06445 ENOG4105K0P flagellar biosynthesis protein F7D04_RS06450 ENOG4105CN7 Flagellar biosynthetic protein FliP F7D04_RS06460 ENOG4105D19 Role in flagellar biosynthesis (By similarity) F7D04_RS06465 ENOG4107TKS colanic acid capsular biosynthesis activation protein A F7D04_RS06475 ENOG4105YX3 cellular response to acidity F7D04_RS06490 ENOG4105VNZ cytoplasmic protein F7D04_RS06495 ENOG4105CKW Inner membrane protein yedI F7D04_RS06500 ENOG4105FDR Membrane F7D04_RS06505 ENOG41090BB DNA mismatch endonuclease (vsr) F7D04_RS06510 ENOG4105DVF Cytosine-specific methyltransferase F7D04_RS06515 ENOG4105EST Metal Dependent Phosphohydrolase F7D04_RS06520 ENOG4105Y0K Inner membrane protein YedR F7D04_RS06525 ENOG4105ZIT Porin Gram-negative type F7D04_RS06535 ENOG4107ZY3 Histidine kinase F7D04_RS06540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F7D04_RS06545 ENOG4105VT2 5-hydroxyisourate hydrolase F7D04_RS06560 ENOG4108MEK Metal-binding protein YodA F7D04_RS06565 ENOG4108VKM cytochrome b561 F7D04_RS06595 ENOG4105CSH Transporter F7D04_RS06600 ENOG4105FYV Amp nucleosidase F7D04_RS06605 ENOG4105CDY transcriptional regulatory protein F7D04_RS06615 ENOG4105UQX Mate efflux family protein F7D04_RS06625 ENOG4107R11 Transcriptional regulator F7D04_RS06630 ENOG4106P55 Transcriptional regulator F7D04_RS06640 ENOG4108PXI ErfK YbiS YcfS YnhG F7D04_RS06655 ENOG4108YZT Adenosylcobinamide kinase F7D04_RS06720 ENOG4108P8R F7D04_RS06730 ENOG4105F4K antigen 43 F7D04_RS06750 ENOG4106H6R UPF0380 protein F7D04_RS06755 ENOG4105MFG Antirestriction protein F7D04_RS06760 ENOG4108YGG dna repair protein F7D04_RS06770 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles F7D04_RS06815 ENOG4105DR8 Membrane F7D04_RS06825 ENOG4105DZ1 carboxypeptidase F7D04_RS06830 ENOG4105CJB Exodeoxyribonuclease I F7D04_RS06840 ENOG4105CUC YeeE YedE family protein F7D04_RS06845 ENOG4105CUB amino acid F7D04_RS06855 ENOG4105EQ1 Transcriptional regulator F7D04_RS06860 ENOG4107SRH Nad-dependent epimerase dehydratase F7D04_RS06865 ENOG4105KRQ Addiction module toxin, Txe YoeB family F7D04_RS06870 ENOG4105VTW prevent-host-death family F7D04_RS06890 ENOG4105CIH Imidazole acetol-phosphate transaminase F7D04_RS06895 ENOG4105ECC imidazole-glycerol-phosphate dehydratase F7D04_RS06900 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F7D04_RS06920 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) F7D04_RS06925 ENOG4105C6Y Udp-glucose 6-dehydrogenase F7D04_RS06930 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) F7D04_RS06965 ENOG4107R8N Glycosyl transferase, family 2 F7D04_RS06980 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase F7D04_RS06995 ENOG4107UKG Glycosyl transferase, family 4 F7D04_RS07000 ENOG4105CMR udp-glucose 4-epimerase F7D04_RS07005 ENOG4105C1B dTDP-glucose 4-6-dehydratase F7D04_RS07010 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F7D04_RS07020 ENOG4107T8Q Glycosyl transferase (Group 1 F7D04_RS07025 ENOG4105C74 pyruvyl transferase F7D04_RS07030 ENOG4105PSV Polysaccharide Biosynthesis Protein F7D04_RS07035 ENOG4105D3Q Sugar transferase F7D04_RS07040 ENOG4107QKV phosphomannomutase F7D04_RS07045 ENOG4105CJT Mannose-1-phosphate guanylyltransferase F7D04_RS07050 ENOG4106CD9 glycosyl transferase group 1 F7D04_RS07055 ENOG4105FGF GDP-mannose mannosyl hydrolase F7D04_RS07060 ENOG4105C30 Nad-dependent epimerase dehydratase F7D04_RS07065 ENOG4105C0K Gdp-mannose 4,6-dehydratase F7D04_RS07070 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF F7D04_RS07075 ENOG4105ECJ Glycosyl Transferase F7D04_RS07080 ENOG4108NYJ Colanic acid F7D04_RS07085 ENOG4107RXY Glycosyl transferase F7D04_RS07090 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB F7D04_RS07095 ENOG41090RK glycosyl transferase F7D04_RS07100 ENOG4105D75 Capsular exopolysaccharide family F7D04_RS07105 ENOG4105KJF protein tyrosine phosphatase F7D04_RS07110 ENOG4105DAY polysaccharide export protein F7D04_RS07120 ENOG4105EE5 Membrane protein terC F7D04_RS07125 ENOG4108GAE asmA family F7D04_RS07135 ENOG4105DBI uridine monophosphokinase F7D04_RS07140 ENOG4105BZU Histidine kinase F7D04_RS07145 ENOG4105D03 DNA-3-methyladenine glycosylase II F7D04_RS07150 ENOG4105R8A Heat shock protein F7D04_RS07155 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding F7D04_RS07160 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase F7D04_RS07165 ENOG4108M24 von Willebrand factor, type A F7D04_RS07205 ENOG4105EB3 Histidine kinase F7D04_RS07210 ENOG4105E3W Two component transcriptional regulator (Winged helix family F7D04_RS07215 ENOG4105KWI UPF0339 protein F7D04_RS07220 ENOG4105X54 addiction module antidote protein F7D04_RS07230 ENOG4105CFP Peptidase U32 F7D04_RS07235 ENOG41076Z6 Uncharacterized protein yegR F7D04_RS07250 ENOG4107WTH Galactitol-1-phosphate dehydrogenase F7D04_RS07255 ENOG4105DT3 PTS system, galactitol-specific IIc component F7D04_RS07260 ENOG41090UW PTS System F7D04_RS07265 ENOG41082GB PTS system galactitol-specific transporter subunit IIA F7D04_RS07280 ENOG4105EIE fructose-bisphosphate aldolase F7D04_RS07285 ENOG4105EAA nucleoside F7D04_RS07290 ENOG4108KD5 ADP-ribosylation crystallin J1 F7D04_RS07295 ENOG4108TFM Kinase, PfkB family F7D04_RS07300 ENOG4105FDP GntR family transcriptional regulator F7D04_RS07310 ENOG4105DWF phosphomethylpyrimidine kinase F7D04_RS07330 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly F7D04_RS07335 ENOG410662B Type-1 fimbrial protein F7D04_RS07340 ENOG4105CW0 outer membrane usher protein F7D04_RS07345 ENOG4108MQF Chaperone F7D04_RS07350 ENOG41063W2 Fimbrial protein F7D04_RS07355 ENOG41067AK Protein of unknown function (DUF2574) F7D04_RS07360 ENOG4105D1F ATP-binding protein F7D04_RS07370 ENOG4108KDT Molybdate metabolism regulator F7D04_RS07375 ENOG4108KDT Molybdate metabolism regulator F7D04_RS07385 ENOG4105KKX ATPase associated with various cellular activities aaa_5 F7D04_RS07390 ENOG4105RD5 F7D04_RS07395 ENOG4105DEG Vwa containing coxe family protein F7D04_RS07400 ENOG410903U zinc ion binding F7D04_RS07405 ENOG4108YCW (LipO)protein F7D04_RS07410 ENOG4108W15 Protein of unknown function (DUF1456) F7D04_RS07415 ENOG4108NEV two component transcriptional regulator, LytTR family F7D04_RS07420 ENOG4108HRK Histidine kinase F7D04_RS07425 ENOG4108XDN Transcriptional regulator F7D04_RS07435 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component F7D04_RS07440 ENOG4108IJ8 ABC transporter F7D04_RS07445 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component F7D04_RS07450 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system F7D04_RS07455 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F7D04_RS07460 ENOG4105CXG d-lactate dehydrogenase F7D04_RS07465 ENOG41061WM D-Alanyl-D-Alanine F7D04_RS07470 ENOG41069YE inner membrane protein yohC F7D04_RS07475 ENOG4105KHU inner membrane protein YohD F7D04_RS07480 ENOG4105H9W Short-chain dehydrogenase reductase Sdr F7D04_RS07485 ENOG4105ETP RND efflux system, outer membrane lipoprotein F7D04_RS07495 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) F7D04_RS07505 ENOG41067MG lrgb family F7D04_RS07515 ENOG4107GZ4 SanA protein F7D04_RS07520 ENOG4105Y9N Membrane F7D04_RS07525 ENOG4105BZ8 glutamate synthase F7D04_RS07530 ENOG4107SJI Dehydrogenase F7D04_RS07535 ENOG4108HWV )-transporter F7D04_RS07540 ENOG4105C2J ABC transporter F7D04_RS07545 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator F7D04_RS07550 ENOG41060NJ transcriptional regulator F7D04_RS07555 ENOG4105DHF Membrane F7D04_RS07570 ENOG4105D05 Receptor F7D04_RS07575 ENOG4108IQI permease F7D04_RS07580 ENOG4105DUM transcriptional regulator, lysR family F7D04_RS07585 ENOG4105HMI Membrane F7D04_RS07595 ENOG4105DD7 kinase (PfkB family F7D04_RS07600 ENOG4105D9N nucleoside F7D04_RS07610 ENOG4108Y4K DNA-binding transcriptional activator F7D04_RS07615 ENOG4105D9N nucleoside F7D04_RS07620 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) F7D04_RS07625 ENOG4105DD7 kinase (PfkB family F7D04_RS07630 ENOG4105DM4 PTS System F7D04_RS07635 ENOG4105DE4 1-phosphofructokinase F7D04_RS07640 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein F7D04_RS07645 ENOG4105S8Q sugar efflux transporter F7D04_RS07650 ENOG4105KRS Proteinase inhibitor F7D04_RS07660 ENOG4105DEI Mannitol dehydrogenase F7D04_RS07665 ENOG4105CKI cobalamin synthesis protein F7D04_RS07670 ENOG41076MN Phosphoesterase, PA-phosphatase related F7D04_RS07675 ENOG4107TT5 NLP P60 protein F7D04_RS07680 ENOG4105CXC rtn protein F7D04_RS07685 ENOG4105E43 Extracellular solute-binding protein, family 5 F7D04_RS07690 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component F7D04_RS07695 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component F7D04_RS07700 ENOG4108JQ5 ABC transporter F7D04_RS07705 ENOG4105HG6 F7D04_RS07710 ENOG4105C2C drug resistance transporter, Bcr CflA F7D04_RS07715 ENOG4105I08 Pseudouridine synthase F7D04_RS07720 ENOG4105CFI type iii restriction protein res subunit F7D04_RS07740 ENOG4105E68 Sulfatase F7D04_RS07750 ENOG4105DFP Integrase F7D04_RS07810 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F7D04_RS07815 ENOG4105FKG DNA packaging protein F7D04_RS07825 ENOG4108MGN ATP-binding component of a transport system F7D04_RS07830 ENOG4105WH1 Two component transcriptional regulator luxr family F7D04_RS07835 ENOG4105KWW Biogenesis protein F7D04_RS07840 ENOG4107QX9 Thiol disulfide interChange protein F7D04_RS07845 ENOG4105DA4 cytochrome c-type biogenesis protein F7D04_RS07855 ENOG4105X3C heme exporter protein F7D04_RS07860 ENOG41060IM Heme exporter protein F7D04_RS07865 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) F7D04_RS07870 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) F7D04_RS07875 ENOG4105CUW cytochrome C-TYPE protein F7D04_RS07880 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) F7D04_RS07885 ENOG4105GXZ Ferredoxin-type protein NapH F7D04_RS07890 ENOG4108BGM Quinol dehydrogenase periplasmic component F7D04_RS07900 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase F7D04_RS07905 ENOG4108ZNS ferredoxin-type protein NapF F7D04_RS07925 ENOG4105IBP Cyclic peptide transporter F7D04_RS07930 ENOG4105CF1 Alkylated DNA repair protein F7D04_RS07935 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F7D04_RS07940 ENOG4105CJ2 (LipO)protein F7D04_RS07945 ENOG4105FCK Membrane F7D04_RS07950 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC F7D04_RS07955 ENOG41068CG regulatoR F7D04_RS07960 ENOG4105BZU Histidine kinase F7D04_RS07965 ENOG4105EDV vault protein F7D04_RS07970 ENOG41081SK signal peptide protein F7D04_RS07975 ENOG4107S52 alpha-2-macroglobulin domain protein F7D04_RS07980 ENOG4108QJJ Protein of unknown function (DUF1175) F7D04_RS07985 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) F7D04_RS07990 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F7D04_RS08000 ENOG4107GHC outer membrane autotransporter F7D04_RS08005 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F7D04_RS08010 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F7D04_RS08015 ENOG4105XPH Ferredoxin F7D04_RS08020 ENOG4105FQR PH-inducible protein involved in stress response F7D04_RS08030 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase F7D04_RS08035 ENOG4105CXY transporter F7D04_RS08040 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A F7D04_RS08050 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F7D04_RS08055 ENOG4105DNE Transposase F7D04_RS08070 ENOG4108UII YfaZ family F7D04_RS08120 ENOG4106GZG polymyxin resistance protein B F7D04_RS08125 ENOG4105CEY Amp-dependent synthetase and ligase F7D04_RS08135 ENOG4108IPT Naphthoate synthase F7D04_RS08150 ENOG4105E4F Isochorismate synthase F7D04_RS08155 ENOG4105TNS Conserved Protein F7D04_RS08160 ENOG4107YB6 acetyltransferase, (GNAT) family F7D04_RS08175 ENOG4105CP2 von willebrand factor, type a F7D04_RS08180 ENOG4107VAM peptidase, m28 F7D04_RS08185 ENOG4105GDX Domain of unknown function (DUF1877) F7D04_RS08195 ENOG4105C8S subunit m F7D04_RS08200 ENOG4105D65 subunit l F7D04_RS08210 ENOG4107UFS subunit j F7D04_RS08225 ENOG4108IEH NADH dehydrogenase subunit g F7D04_RS08230 ENOG4107QIZ NADH dehydrogenase F7D04_RS08235 ENOG4105GKE subunit e F7D04_RS08255 ENOG4107NQ8 LysR family Transcriptional regulator F7D04_RS08260 ENOG4105CHM Aminotransferase F7D04_RS08270 ENOG4107QWE )-transporter F7D04_RS08275 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 F7D04_RS08280 ENOG4105XWI UPF0304 protein F7D04_RS08290 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F7D04_RS08295 ENOG4105C6K Malic enzyme F7D04_RS08300 ENOG4105CSX c4-dicarboxylate anaerobic carrier F7D04_RS08305 ENOG4105PTV Nudix Hydrolase F7D04_RS08310 ENOG4108RE9 Phosphodiesterase F7D04_RS08315 ENOG4108SHQ Glutathione S-transferase F7D04_RS08320 ENOG4105CYM Glutathione S-transferase F7D04_RS08325 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase F7D04_RS08330 ENOG4105ECP epimerase F7D04_RS08335 ENOG4105DNE Transposase F7D04_RS08340 ENOG4108JEH abc transporter atp-binding protein F7D04_RS08345 ENOG4106YG3 ABC transporter F7D04_RS08350 ENOG4105DSP amino acid AbC transporter F7D04_RS08355 ENOG4105E89 ABC transporter F7D04_RS08360 ENOG4105E89 ABC transporter F7D04_RS08365 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase F7D04_RS08370 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase F7D04_RS08375 ENOG4105E96 Colicin v production protein F7D04_RS08380 ENOG4108S3P Sporulation domain protein F7D04_RS08385 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F7D04_RS08395 ENOG4105DQR SNARE associated Golgi F7D04_RS08405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F7D04_RS08420 ENOG4105F9N Major Facilitator Superfamily F7D04_RS08425 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F7D04_RS08430 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) F7D04_RS08435 ENOG4105MH2 YfcL protein F7D04_RS08440 ENOG4108BPE -transporting atpase F7D04_RS08445 ENOG4105EJ9 Membrane F7D04_RS08475 ENOG4105US4 fimbrial-like protein yfcP F7D04_RS08480 ENOG4105UGQ Fimbrial F7D04_RS08485 ENOG4105NEV Fimbrial F7D04_RS08490 ENOG4108FZ9 Chaperone F7D04_RS08510 ENOG4108BY2 phosphohistidine phosphatase F7D04_RS08525 ENOG4105KZW UPF0381 protein F7D04_RS08530 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation F7D04_RS08540 ENOG410903C (LipO)protein F7D04_RS08545 ENOG4105S64 Formate nitrite transporter F7D04_RS08555 ENOG4105DFP Integrase F7D04_RS08605 ENOG41067TZ transcriptional regulator, MarR family F7D04_RS08615 ENOG4105DH8 myo-inositol catabolism F7D04_RS08625 ENOG4105D7K pfkb domain protein F7D04_RS08635 ENOG4105CNN ABC, transporter F7D04_RS08645 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F7D04_RS08655 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) F7D04_RS08660 ENOG4105C26 Dehydrogenase F7D04_RS08690 ENOG4105EYM Major Facilitator superfamily F7D04_RS08695 ENOG4105BZ1 (ABC) transporter F7D04_RS08710 ENOG4105C0W non-ribosomal peptide synthetase F7D04_RS08730 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F7D04_RS08735 ENOG4107ZSV Receptor F7D04_RS08740 ENOG4107ENK receptor F7D04_RS08750 ENOG4108WF3 methyltransferase F7D04_RS08765 ENOG4105GTN ParB Domain Protein Nuclease F7D04_RS08770 ENOG4105BZV Phosphoadenosine phosphosulfate reductase F7D04_RS08780 ENOG4105EKQ RNA-directed DNA polymerase F7D04_RS08785 ENOG4105QYK bacteriophage lambda Bor protein homolog F7D04_RS08850 ENOG4105E93 esterase F7D04_RS08855 ENOG4105NIV Esterase F7D04_RS08860 ENOG4107RNH Outer membrane receptor FepA F7D04_RS08895 ENOG4107W19 lmbE family F7D04_RS08900 ENOG4108PBI Polysaccharide metabolism F7D04_RS08910 ENOG4105SRB Uncharacterized protein yaiO F7D04_RS08945 ENOG4108V08 YfdX protein F7D04_RS08955 ENOG4105W9M Membrane F7D04_RS08960 ENOG4105D1S lipid A biosynthesis F7D04_RS08970 ENOG4105CHM Aminotransferase F7D04_RS08975 ENOG4108HRK Histidine kinase F7D04_RS08980 ENOG4105DY9 regulatoR F7D04_RS08985 ENOG4108CIP transcriptional regulator F7D04_RS08990 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F7D04_RS08995 ENOG4105CN9 Peptidase m42 family protein F7D04_RS09000 ENOG4105DC7 peptidase M24 F7D04_RS09005 ENOG410863U PTS System F7D04_RS09010 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) F7D04_RS09020 ENOG4105VCT ion-transport protein YfeO F7D04_RS09025 ENOG4109076 Conserved Protein F7D04_RS09035 ENOG4105D9N nucleoside F7D04_RS09040 ENOG4108KMM Diguanylate cyclase F7D04_RS09055 ENOG4105HZG regulatoR F7D04_RS09060 ENOG4105GXM Putative transcription regulator (DUF1323) F7D04_RS09090 ENOG4105CN8 Transcriptional regulator F7D04_RS09100 ENOG4105EAA nucleoside F7D04_RS09105 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) F7D04_RS09115 ENOG4108M0I Transcriptional regulator F7D04_RS09120 ENOG4105DHU Bile acid F7D04_RS09125 ENOG4105VRT cytoplasmic protein F7D04_RS09145 ENOG4105C6T cysteine synthase F7D04_RS09155 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F7D04_RS09160 ENOG4105C5Y PTS System F7D04_RS09170 ENOG4105M0Y F7D04_RS09175 ENOG4105C6T cysteine synthase F7D04_RS09180 ENOG4108IJ6 ABC transporter F7D04_RS09185 ENOG4105ECW sulfate abc transporter F7D04_RS09190 ENOG4108I5D sulfate abc transporter F7D04_RS09195 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein F7D04_RS09200 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr F7D04_RS09215 ENOG4105C5Y PTS System F7D04_RS09220 ENOG4107S1E Beta-lactamase F7D04_RS09225 ENOG4105EZR dyp-type peroxidase family protein F7D04_RS09230 ENOG4105E7K (LipO)protein F7D04_RS09235 ENOG4105QZU Inner membrane protein YfeZ F7D04_RS09245 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase F7D04_RS09255 ENOG4108K3Z AraC family transcriptional regulator F7D04_RS09260 ENOG4108X49 Ethanolamine utilization protein EutK F7D04_RS09265 ENOG4106D67 ethanolamine utilization protein F7D04_RS09275 ENOG4105CPD ethanolamine ammonia-lyase F7D04_RS09280 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase F7D04_RS09285 ENOG4105ENY Ethanolamine utilization protein eutH F7D04_RS09290 ENOG4105C0A alcohol dehydrogenase F7D04_RS09295 ENOG4107RWI ethanolamine utilization protein eutJ F7D04_RS09300 ENOG4108EKI Dehydrogenase F7D04_RS09305 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml F7D04_RS09310 ENOG4105KNY Microcompartments protein F7D04_RS09315 ENOG4107WUY phosphate acetyltransferase F7D04_RS09320 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase F7D04_RS09325 ENOG4105NDK ethanolamine utilization protein F7D04_RS09330 ENOG4106S4J ethanolamine utilization protein EutP F7D04_RS09335 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place F7D04_RS09340 ENOG4105C6K Malic enzyme F7D04_RS09345 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F7D04_RS09350 ENOG4105CV1 Transketolase (EC 2.2.1.1) F7D04_RS09355 ENOG4108PVD exported protein F7D04_RS09365 ENOG4105BZ8 glutamate synthase F7D04_RS09370 ENOG4105BZU Histidine kinase F7D04_RS09375 ENOG4105BZS acriflavin resistance protein F7D04_RS09385 ENOG4105KUZ arsenate reductase F7D04_RS09400 ENOG4106KED esterase YpfH F7D04_RS09405 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) F7D04_RS09410 ENOG4105CGZ zinc metallopeptidase F7D04_RS09415 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A F7D04_RS09430 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F7D04_RS09440 ENOG4105RH4 Glycine cleavage system transcriptional repressor F7D04_RS09445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F7D04_RS09450 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) F7D04_RS09455 ENOG4108JPZ Monovalent cation H antiporter subunit D F7D04_RS09460 ENOG4107TDF Formate hydrogenlyase subunit 4 F7D04_RS09465 ENOG4105D65 subunit l F7D04_RS09470 ENOG4107WQX hydrogenase 4 membrane subunit F7D04_RS09475 ENOG4108JPZ Monovalent cation H antiporter subunit D F7D04_RS09480 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F7D04_RS09490 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit F7D04_RS09495 ENOG4105I6X formate hydrogenlyase maturation F7D04_RS09505 ENOG4105TMB Formate nitrite transporter F7D04_RS09510 ENOG4105C02 permease F7D04_RS09515 ENOG4105ERG peptidase m48, ste24p F7D04_RS09520 ENOG4105K89 arsenate reductase F7D04_RS09525 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) F7D04_RS09530 ENOG4105C2W permease F7D04_RS09545 ENOG4108V3E phosphoribosylglycinamide formyltransferase F7D04_RS09550 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F7D04_RS09555 ENOG4105C9X ppx gppa phosphatase F7D04_RS09560 ENOG4105BZU Histidine kinase F7D04_RS09570 ENOG41062G3 Protein of unknown function (DUF2633) F7D04_RS09575 ENOG4108ZMA Outer membrane lipoprotein F7D04_RS09580 ENOG41066DY Membrane F7D04_RS09590 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F7D04_RS09600 ENOG4105VPD cellular component movement F7D04_RS09615 ENOG4105N21 Membrane F7D04_RS09645 ENOG4108JQB penicillin-binding protein 1C F7D04_RS09650 ENOG4105DN3 alpha-2-macroglobulin domain protein F7D04_RS09660 ENOG4105YYA enhanced serine sensitivity protein SseB F7D04_RS09670 ENOG4105WVQ Fe-S assembly protein IscX F7D04_RS09675 ENOG4108ZIT Ferredoxin, 2FE-2S F7D04_RS09695 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins F7D04_RS09715 ENOG4105ECY inositol monophosphatase F7D04_RS09720 ENOG4107XM9 (LipO)protein F7D04_RS09725 ENOG4108MN2 Stationary phase inducible protein CsiE F7D04_RS09735 ENOG4108W5M transcriptional regulator F7D04_RS09740 ENOG4105FUY alpha subunit F7D04_RS09765 ENOG4108SB3 DoxX Family F7D04_RS09770 ENOG4108ZKT aldose 1-epimerase F7D04_RS09775 ENOG4105CPQ Dehydrogenase F7D04_RS09780 ENOG4105CNN ABC, transporter F7D04_RS09785 ENOG4108F37 ATP-binding component of a transport system F7D04_RS09790 ENOG4105FCA ABC transporter periplasmic-binding protein YphF F7D04_RS09795 ENOG4107HQ7 repeat protein F7D04_RS09800 ENOG4108NZE NAGC-like transcriptional regulator F7D04_RS09810 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F7D04_RS09820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F7D04_RS09825 ENOG4108SKK alpha helix protein F7D04_RS09830 ENOG4107WP9 Histidine kinase F7D04_RS09845 ENOG4108Z6B deaminase F7D04_RS09850 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB F7D04_RS09855 ENOG4106G6Q Transcriptional regulator F7D04_RS09860 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding F7D04_RS09875 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) F7D04_RS09895 ENOG4105C3F Signal peptidase i F7D04_RS09905 ENOG4105WMJ Positive regulator of sigma E, RseC MucC F7D04_RS09910 ENOG4105VQK sigma E regulatory protein, MucB RseB F7D04_RS09915 ENOG41069PW sigma-e factor negative regulatory protein F7D04_RS09920 ENOG4105EMN RNA polymerase sigma factor F7D04_RS09930 ENOG4108IYU L-aspartate oxidase F7D04_RS09940 ENOG4105C1J atp-dependent rna helicase F7D04_RS09945 ENOG41090KR LysR family transcriptional Regulator F7D04_RS09965 ENOG4105EIB trna rrna methyltransferase F7D04_RS09970 ENOG4105K63 Thioredoxin F7D04_RS09975 ENOG4106IUH DTW domain containing protein F7D04_RS09980 ENOG4105CD5 CoA-binding domain protein F7D04_RS09985 ENOG4105JIM Phosphatidylserine synthase F7D04_RS09990 ENOG4105T42 (LipO)protein F7D04_RS09995 ENOG4105CSH Transporter F7D04_RS10020 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F7D04_RS10025 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F7D04_RS10030 ENOG4105C34 Pseudouridine synthase F7D04_RS10035 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F7D04_RS10040 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA F7D04_RS10050 ENOG4105CQC Prephenate dehydratase F7D04_RS10055 ENOG4105EHE chorismate mutase- prephenate dehydrogenase F7D04_RS10060 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F7D04_RS10065 ENOG4105QP9 Protein of unknown function (DUF2799) F7D04_RS10070 ENOG4108WS1 F7D04_RS10075 ENOG4108KHX Diguanylate cyclase F7D04_RS10080 ENOG41090EK ompa motb domain protein F7D04_RS10105 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY F7D04_RS10110 ENOG4106KVJ cytochrome C assembly protein F7D04_RS10115 ENOG4108JU6 CBS domain protein F7D04_RS10130 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F7D04_RS10135 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F7D04_RS10145 ENOG4108Z1B Cyclase dehydrase F7D04_RS10160 ENOG4105DFP Integrase F7D04_RS10255 ENOG4105D5U fad dependent oxidoreductase F7D04_RS10265 ENOG4108JPW Aminotransferase F7D04_RS10270 ENOG4105C85 amino acid F7D04_RS10275 ENOG4108PVQ transcriptional regulator F7D04_RS10280 ENOG4109066 lysm domain bon superfamily protein F7D04_RS10285 ENOG4105VPI YqaE family transport protein F7D04_RS10290 ENOG41080HT Transcriptional regulator, arsr family F7D04_RS10295 ENOG4108V62 Rhodanese domain protein F7D04_RS10300 ENOG4108X73 DNA- binding protein F7D04_RS10305 ENOG4108RNS Exports L-alanine (By similarity) F7D04_RS10310 ENOG4108WMJ Protein of unknown function (DUF2002) F7D04_RS10315 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) F7D04_RS10320 ENOG4105WAZ (Glutaredoxin-like protein) NrdH F7D04_RS10330 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F7D04_RS10335 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F7D04_RS10340 ENOG4108IJ7 Glycine betaine F7D04_RS10345 ENOG4108HQS Glycine betaine F7D04_RS10350 ENOG4105GIJ Glycine betaine F7D04_RS10360 ENOG4108UMN azlc family F7D04_RS10365 ENOG4105ZED uncharacterized protein ygaH F7D04_RS10370 ENOG4105NTK Transcriptional repressor Mpra F7D04_RS10375 ENOG4105CW7 secretion protein, HlyD family F7D04_RS10380 ENOG4105C0R drug resistance transporter emrb qaca subfamily F7D04_RS10395 ENOG4105W39 Membrane F7D04_RS10400 ENOG4107VXZ Hydrolase F7D04_RS10425 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) F7D04_RS10445 ENOG4107TH8 cina domain protein F7D04_RS10450 ENOG4105CVE Lytic murein transglycosylase F7D04_RS10455 ENOG410787A Pts system, glucitol sorbitol-specific F7D04_RS10460 ENOG4105DZY Pts system, glucitol sorbitol-specific F7D04_RS10465 ENOG4105VI0 Pts system, glucitol sorbitol-specific F7D04_RS10470 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase F7D04_RS10475 ENOG4105J92 DNA-binding transcriptional activator GutM F7D04_RS10480 ENOG410804X Transcriptional regulator F7D04_RS10485 ENOG4105C2X Arabinose 5-phosphate isomerase F7D04_RS10505 ENOG4105C8H hydrogenase maturation protein Hypf F7D04_RS10510 ENOG4108RC0 Electron transport protein F7D04_RS10515 ENOG4105DDV Transcriptional regulator (LacI family F7D04_RS10520 ENOG4105C5Y PTS System F7D04_RS10525 ENOG4105CS2 ec 3.2.1.21 F7D04_RS10530 ENOG4108Z3N Transcriptional regulator F7D04_RS10535 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) F7D04_RS10545 ENOG4108MG9 hydrogenase 3 maturation protease F7D04_RS10550 ENOG4105I6X formate hydrogenlyase maturation F7D04_RS10555 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit F7D04_RS10560 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit F7D04_RS10565 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F7D04_RS10570 ENOG4107TDF Formate hydrogenlyase subunit 4 F7D04_RS10575 ENOG4107R30 NADH dehydrogenase F7D04_RS10580 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) F7D04_RS10585 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA F7D04_RS10590 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) F7D04_RS10595 ENOG4107RSS Hydrogenase accessory protein HypB F7D04_RS10600 ENOG41083WG hydrogenase assembly chaperone F7D04_RS10605 ENOG4105CQS hydrogenase expression formation protein HypD F7D04_RS10610 ENOG4105C45 hydrogenase expression formation protein (HypE) F7D04_RS10615 ENOG4108JUA Transcriptional regulator F7D04_RS10620 ENOG4105VXR cytoplasmic protein F7D04_RS10635 ENOG4105MEW serine threonine protein phosphatase F7D04_RS10640 ENOG4105MVE transcriptional regulator F7D04_RS10645 ENOG4105ZXK Dehydrogenase F7D04_RS10650 ENOG4105G63 Type III effector Hrp-dependent F7D04_RS10655 ENOG4105FB2 class II Aldolase F7D04_RS10660 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F7D04_RS10665 ENOG4105C6Z Gluconate F7D04_RS10670 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F7D04_RS10675 ENOG4108K5P (LipO)protein F7D04_RS10710 ENOG4105N0Z inner membrane protein ygbE F7D04_RS10720 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) F7D04_RS10725 ENOG4105C11 sulfate adenylyltransferase), subunit 2 F7D04_RS10730 ENOG4108MXK alkaline phosphatase isozyme conversion F7D04_RS10735 ENOG4105PWE CRISPR-associated protein cas2 F7D04_RS10740 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) F7D04_RS10750 ENOG4108VWQ crispr-associated protein F7D04_RS10755 ENOG41060M0 Crispr-associated protein, cse4 family F7D04_RS10765 ENOG4105CYR Crispr-associated protein, cse1 family F7D04_RS10770 ENOG4105DTT CRISPR-associated helicase, cas3 F7D04_RS10775 ENOG4107635 Hok Gef family protein F7D04_RS10795 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F7D04_RS10800 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase F7D04_RS10805 ENOG4105WQV ferredoxin-like protein F7D04_RS10810 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F7D04_RS10815 ENOG4105YBM electron transfer flavoprotein subunit ygcQ F7D04_RS10820 ENOG4106IKH Electron transfer flavoprotein F7D04_RS10825 ENOG4105C54 Major Facilitator superfamily F7D04_RS10830 ENOG4107R3A FAD linked oxidase domain protein F7D04_RS10835 ENOG4105CHR reductase F7D04_RS10840 ENOG4108ITV Inner membrane protein yqcE F7D04_RS10845 ENOG4108CWB sugar kinase ygcE F7D04_RS10850 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F7D04_RS10860 ENOG4105HA9 of methanol dehydrogenase type F7D04_RS10875 ENOG4105DXN mazG family F7D04_RS10880 ENOG4105MZG transcriptional modulator of maze toxin, mazf F7D04_RS10885 ENOG4106A2Z transcriptional regulator antitoxin, MazE F7D04_RS10890 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F7D04_RS10895 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F7D04_RS10900 ENOG4105BZU Histidine kinase F7D04_RS10905 ENOG4105EQX glucarate dehydratase F7D04_RS10910 ENOG4105EQX glucarate dehydratase F7D04_RS10915 ENOG4105DJB Major Facilitator Superfamily F7D04_RS10920 ENOG4105QDK Flavodoxin F7D04_RS10925 ENOG4105DR9 pseudouridine synthase F7D04_RS10930 ENOG4105WP7 tRNA pseudouridine synthase C F7D04_RS10945 ENOG4105EWT decarboxylase family F7D04_RS10950 ENOG4105C44 Serine transporter F7D04_RS10955 ENOG4105EJQ L-serine dehydratase F7D04_RS10965 ENOG4105C0A alcohol dehydrogenase F7D04_RS10970 ENOG4107W7X Aldolase F7D04_RS10975 ENOG4105EDR glucose galactose transporter F7D04_RS10985 ENOG4105CMG Carbohydrate kinase F7D04_RS10995 ENOG4107EDW L-fucose operon activator F7D04_RS11005 ENOG4105M08 Membrane F7D04_RS11010 ENOG4105ETT transcriptional Regulator, LysR family F7D04_RS11015 ENOG4105M5B (LipO)protein F7D04_RS11020 ENOG4105C9B Cysteine desulfurase F7D04_RS11025 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) F7D04_RS11030 ENOG4105CUZ uba thif-type nad fad binding protein F7D04_RS11035 ENOG4105CA3 membrane-bound lytic murein transglycosylase F7D04_RS11055 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F7D04_RS11060 ENOG4108EKC n-acetylglutamate synthase F7D04_RS11065 ENOG4107QYX exodeoxyribonuclease v alpha F7D04_RS11070 ENOG4107QKA exodeoxyribonuclease V beta F7D04_RS11075 ENOG4107QXK peptidase F7D04_RS11080 ENOG4105DSY exodeoxyribonuclease V, gamma F7D04_RS11085 ENOG4105RVB Prepilin peptidase dependent protein c F7D04_RS11090 ENOG4105SEN Protein of unknown function (DUF2509) F7D04_RS11095 ENOG4105JCS prepilin peptidase dependent protein F7D04_RS11100 ENOG4105IPU prepilin peptidase dependent protein A F7D04_RS11115 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase F7D04_RS11130 ENOG4105EE5 Membrane protein terC F7D04_RS11135 ENOG4105SUV lipoprotein YgdR F7D04_RS11140 ENOG4105CPC Aldo Keto reductase F7D04_RS11145 ENOG4107S74 Lysophospholipid transporter LplT F7D04_RS11155 ENOG41060NJ transcriptional regulator F7D04_RS11165 ENOG4105RQF LysR family Transcriptional regulator F7D04_RS11175 ENOG4107QNK )-transporter F7D04_RS11180 ENOG4105CHR reductase F7D04_RS11190 ENOG4105CHU acetyl-coa acetyltransferase F7D04_RS11195 ENOG4108MHD transport protein F7D04_RS11200 ENOG4105ISV protein with bipartite regulator domain F7D04_RS11205 ENOG4108TC1 Transcriptional regulator F7D04_RS11210 ENOG4105FV3 F7D04_RS11235 ENOG4108YAB Invasion protein F7D04_RS11265 ENOG4108RBT type iii secretion F7D04_RS11280 ENOG4108RC9 Type III secretion system protein F7D04_RS11295 ENOG4108M6W surface presentation of antigens protein SpaS F7D04_RS11300 ENOG4108M6W surface presentation of antigens protein SpaS F7D04_RS11305 ENOG4108M6W surface presentation of antigens protein SpaS F7D04_RS11310 ENOG4108TN6 type iii secretion F7D04_RS11315 ENOG4105U07 type iii secretion F7D04_RS11320 ENOG41075IY surface presentation of antigens protein SpaP F7D04_RS11380 ENOG4105GNX MltA-interacting MipA family protein F7D04_RS11390 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F7D04_RS11405 ENOG4108UUM single-stranded DNA-binding protein F7D04_RS11630 ENOG4105HMV Fimbrial protein F7D04_RS11635 ENOG4108ZJG MrfB protein F7D04_RS11640 ENOG4106PG1 outer membrane usher protein F7D04_RS11645 ENOG4106P2F Pfam:Pili_assembly_C F7D04_RS11655 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR F7D04_RS11685 ENOG4108Z33 Thiol disulfide Interchange Protein F7D04_RS11720 ENOG4108T88 F7D04_RS11730 ENOG4108K5P (LipO)protein F7D04_RS11735 ENOG4105C7W Xanthine dehydrogenase F7D04_RS11745 ENOG4108UTP (2Fe-2S)-binding domain protein F7D04_RS11750 ENOG4108JUB Transcriptional regulator F7D04_RS11755 ENOG4105IW6 Carbamoyltransferase F7D04_RS11760 ENOG4107RCH Diaminopropionate ammonia-lyase F7D04_RS11765 ENOG4107S4Y M20 DapE family protein YgeY F7D04_RS11775 ENOG4105C5B carbamate kinase F7D04_RS11780 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family F7D04_RS11785 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC F7D04_RS11790 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase F7D04_RS11795 ENOG4105BZ8 glutamate synthase F7D04_RS11800 ENOG4107UUR Chlorohydrolase aminohydrolase F7D04_RS11805 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase F7D04_RS11810 ENOG4105C7W Xanthine dehydrogenase F7D04_RS11815 ENOG4105C2W permease F7D04_RS11820 ENOG4107QUY Guanine deaminase F7D04_RS11825 ENOG4105C7N Xanthine uracil vitamin C permease F7D04_RS11830 ENOG4108R8B oxidoreductase Fe-S subunit F7D04_RS11835 ENOG4105BZ8 glutamate synthase F7D04_RS11840 ENOG4105C2W permease F7D04_RS11870 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F7D04_RS11875 ENOG4105T95 Thiol disulfide interChange protein F7D04_RS11880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F7D04_RS11885 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) F7D04_RS11890 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB F7D04_RS11895 ENOG4105Y75 tpr repeat protein F7D04_RS11905 ENOG4108UT2 hemolysin iii F7D04_RS11910 ENOG4105N5Z UPF0267 protein F7D04_RS11915 ENOG4105CS2 ec 3.2.1.21 F7D04_RS11925 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor F7D04_RS11945 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F7D04_RS11950 ENOG4105D0A hydroxylase F7D04_RS11955 ENOG4107RAQ aminopeptidase F7D04_RS11975 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F7D04_RS11985 ENOG4108JQ1 Dehydrogenase F7D04_RS12005 ENOG4105D5P Methylmalonyl-coA mutase F7D04_RS12010 ENOG4105DJT lAO AO transport system ATPase F7D04_RS12015 ENOG4108M7F enoyl-CoA hydratase isomerase F7D04_RS12020 ENOG4105CYC Transferase F7D04_RS12025 ENOG4105DEQ transcriptional regulator F7D04_RS12030 ENOG4105MPN Membrane F7D04_RS12035 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F7D04_RS12040 ENOG4105D64 Mechanosensitive ion channel F7D04_RS12045 ENOG4105D2N Aldolase F7D04_RS12075 ENOG4108JJB ABC transporter F7D04_RS12080 ENOG4108JJB ABC transporter F7D04_RS12085 ENOG4107Z1W Fructose transport system kinase F7D04_RS12090 ENOG4108R4K DNA-binding, transcriptional regulator F7D04_RS12095 ENOG4108Q8A Fructose-1,6-bisphosphatase F7D04_RS12100 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein F7D04_RS12105 ENOG4105CTS PTS system mannitol-specific F7D04_RS12110 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia F7D04_RS12115 ENOG4105CV1 Transketolase (EC 2.2.1.1) F7D04_RS12120 ENOG4108K0D peptidase, M48 F7D04_RS12135 ENOG4105F3R pts system mannose fructose sorbose family iid F7D04_RS12140 ENOG4105ETZ PTS System F7D04_RS12145 ENOG4105DAS pts system F7D04_RS12170 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) F7D04_RS12190 ENOG4107QNK )-transporter F7D04_RS12200 ENOG4105RWS endonuclease I F7D04_RS12205 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F7D04_RS12210 ENOG4105D7Z glutathione synthase F7D04_RS12225 ENOG4105CZX twitching motility protein F7D04_RS12230 ENOG4105DFA alanine racemase domain protein F7D04_RS12235 ENOG4108VIA integral membrane protein F7D04_RS12245 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F7D04_RS12250 ENOG4105CSA Coproporphyrinogen iii oxidase F7D04_RS12255 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit F7D04_RS12260 ENOG41069H7 transport system small permease component F7D04_RS12265 ENOG4105CG6 trap dicarboxylate transporter dctm subunit F7D04_RS12270 ENOG4106MH3 alpha helix chain F7D04_RS12275 ENOG4105HDK L-asparaginase F7D04_RS12280 ENOG4105K33 Periplasmic Protein F7D04_RS12285 ENOG41090ED Protein with unknown function (DUF469) F7D04_RS12295 ENOG4105CEN a g-specific adenine glycosylase F7D04_RS12310 ENOG4105EAA nucleoside F7D04_RS12315 ENOG4105CXN decarboxylase F7D04_RS12320 ENOG4108UQV Membrane F7D04_RS12340 ENOG41088T4 Helicase IV F7D04_RS12355 ENOG4105GTN ParB Domain Protein Nuclease F7D04_RS12360 ENOG4105BZV Phosphoadenosine phosphosulfate reductase F7D04_RS12380 ENOG4105H38 Membrane F7D04_RS12395 ENOG4105CKT filamentous hemagglutinin F7D04_RS12405 ENOG4105D5K Hemolysin activator protein F7D04_RS12445 ENOG4108V08 YfdX protein F7D04_RS12495 ENOG4105F4K antigen 43 F7D04_RS12500 ENOG4108PZQ Inner membrane protein YeeR F7D04_RS12515 ENOG4106H6R UPF0380 protein F7D04_RS12520 ENOG4105MFG Antirestriction protein F7D04_RS12525 ENOG4108YGG dna repair protein F7D04_RS12535 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles F7D04_RS12560 ENOG4105U1E general secretion pathway protein M F7D04_RS12580 ENOG4105X5Z General secretion pathway protein I F7D04_RS12590 ENOG4108VAU general secretion pathway protein G F7D04_RS12595 ENOG4105D7Q type ii secretion system F7D04_RS12635 ENOG410685N tail fiber protein F7D04_RS12645 ENOG41061A0 Mu-like prophage Flumu protein F7D04_RS12650 ENOG4108T86 baseplate J family protein F7D04_RS12685 ENOG41062PQ Mu-like prophage FluMu protein gp41 F7D04_RS12695 ENOG4105TKZ Tail Sheath F7D04_RS12725 ENOG4105EFV Major head subunit F7D04_RS12745 ENOG4105CF2 Mu-like prophage FluMu protein GP28 F7D04_RS12750 ENOG4108Z6H mu-like prophage Flumu protein gp27 F7D04_RS12825 ENOG4105IKI host-nuclease inhibitor protein F7D04_RS12845 ENOG4108WTW DNA transposition protein F7D04_RS12850 ENOG4106YXT transposase F7D04_RS12855 ENOG4105R8V Transcriptional regulator F7D04_RS12880 ENOG410765S (LipO)protein F7D04_RS12895 ENOG4105DAA L-lactate F7D04_RS12900 ENOG4107QP3 malate synthase g F7D04_RS12905 ENOG4108ZJF Glcg protein F7D04_RS12910 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F7D04_RS12920 ENOG4105CQB FAD linked oxidase domain protein F7D04_RS12925 ENOG4108KWP DNA-binding transcriptional regulator GlcC F7D04_RS12935 ENOG4107RCI amp-dependent synthetase and ligase F7D04_RS12945 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F7D04_RS12950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F7D04_RS12960 ENOG4108M8S permease YjgP YjgQ family protein F7D04_RS12965 ENOG4108UUE Transcriptional regulator F7D04_RS12975 ENOG4108S55 polysaccharide biosynthesis protein F7D04_RS12980 ENOG4106FPV ATP-binding protein YghR F7D04_RS12985 ENOG4108NDC ATP-binding protein yghS F7D04_RS12990 ENOG4108GH0 ATP-binding protein yghT F7D04_RS12995 ENOG4105CJ3 phosphate transporter F7D04_RS13000 ENOG4106032 Glutathionylspermidine synthase F7D04_RS13005 ENOG4105CYM Glutathione S-transferase F7D04_RS13015 ENOG41082MF Hydrogenase assembly chaperone hypC hupF F7D04_RS13020 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) F7D04_RS13025 ENOG4108WGS hydrogenase 2-specific chaperone F7D04_RS13030 ENOG4108USZ hydrogenase F7D04_RS13035 ENOG4105DPX Hydrogenase, large subunit F7D04_RS13040 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit F7D04_RS13045 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F7D04_RS13050 ENOG4105E3S small subunit F7D04_RS13055 ENOG410900S Protein of unknown function (DUF2623) F7D04_RS13065 ENOG4105CPC Aldo Keto reductase F7D04_RS13075 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F7D04_RS13080 ENOG4108ZZF transport protein (ExbD) F7D04_RS13085 ENOG4105CWK Biopolymer transport protein, ExbB F7D04_RS13090 ENOG4105C28 cystathionine F7D04_RS13095 ENOG4108K81 inner membrane protein YghB F7D04_RS13100 ENOG4105CF7 AraC family transcriptional regulator F7D04_RS13105 ENOG4108I6A alcohol dehydrogenase F7D04_RS13110 ENOG4105CV8 reductase F7D04_RS13115 ENOG4105ZKC Conserved Protein F7D04_RS13125 ENOG4105CCT upf0313 protein F7D04_RS13130 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) F7D04_RS13135 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase F7D04_RS13140 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F7D04_RS13145 ENOG4105F4I Transcriptional regulator F7D04_RS13150 ENOG4105H4F exported protein F7D04_RS13155 ENOG4105XJC Two component transcriptional regulator (Winged helix family F7D04_RS13165 ENOG4107DEU Inner membrane protein YgiZ F7D04_RS13170 ENOG4105NF4 modulator of drug activity F7D04_RS13175 ENOG4105VRH Antibiotic biosynthesis monooxygenase F7D04_RS13180 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F7D04_RS13185 ENOG4105IPS esterase F7D04_RS13190 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) F7D04_RS13195 ENOG4108SX3 cytoplasmic protein F7D04_RS13200 ENOG41087AY ADP-Ribose pyrophosphatase F7D04_RS13205 ENOG4105DFG type I secretion outer membrane protein F7D04_RS13215 ENOG4106032 Glutathionylspermidine synthase F7D04_RS13220 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F7D04_RS13240 ENOG4105W0Z cytoplasmic protein F7D04_RS13245 ENOG4105H8W Fimbrial protein F7D04_RS13255 ENOG4108TTM chaperone F7D04_RS13260 ENOG4108MY7 Fimbrial F7D04_RS13270 ENOG4105PV3 Inner membrane protein yqiJ F7D04_RS13275 ENOG4107S78 Band 7 protein F7D04_RS13300 ENOG4105I7R Adenylate cyclase F7D04_RS13305 ENOG4106MWK domain protein F7D04_RS13320 ENOG4107ZVW dihydroneopterin aldolase F7D04_RS13330 ENOG4105EJC lysr family transcriptional regulator F7D04_RS13335 ENOG4106DSS Tartrate dehydratase subunit alpha F7D04_RS13340 ENOG4107GFK fumarate F7D04_RS13350 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F7D04_RS13360 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F7D04_RS13365 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F7D04_RS13380 ENOG4105Q26 Siderophore-interacting protein F7D04_RS13385 ENOG4105NTW Transcriptional regulator F7D04_RS13390 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor F7D04_RS13400 ENOG4108Y51 tRNA-binding protein F7D04_RS13405 ENOG4105CQ4 Transcriptional regulator F7D04_RS13410 ENOG4105CNT hydrolase family 2 F7D04_RS13415 ENOG4105FK9 beta-D-galactosidase beta subunit F7D04_RS13420 ENOG4105E5D amino acid F7D04_RS13425 ENOG4107W6W Conserved Protein F7D04_RS13430 ENOG4107WCA isomerase F7D04_RS13435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F7D04_RS13440 ENOG4108Z3N Transcriptional regulator F7D04_RS13455 ENOG4108VKG metal-dependent hydrolase F7D04_RS13460 ENOG4108UB4 uncharacterized protein ygjQ F7D04_RS13465 ENOG4105EE0 oxidoreductase F7D04_RS13470 ENOG4105DU1 integral membrane protein, terc F7D04_RS13475 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) F7D04_RS13480 ENOG4105P66 Membrane F7D04_RS13485 ENOG4105CTX dehydratase F7D04_RS13495 ENOG4105DPW Major facilitator superfamily MFS_1 F7D04_RS13520 ENOG4107YCY Transcriptional regulator F7D04_RS13525 ENOG4106W5V Membrane F7D04_RS13530 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) F7D04_RS13535 ENOG4105WAY exported protein F7D04_RS13540 ENOG4105NE1 Conserved Protein F7D04_RS13545 ENOG41090KG Inner membrane protein YqjE F7D04_RS13550 ENOG4105YJD F7D04_RS13555 ENOG4108VBZ doxx family F7D04_RS13560 ENOG4105CHF Glutathione S-transferase F7D04_RS13565 ENOG4105KAF membrAne F7D04_RS13570 ENOG4105KAF membrAne F7D04_RS13575 ENOG4105CWB LysR family transcriptional Regulator F7D04_RS13580 ENOG4108CNN domain protein F7D04_RS13585 ENOG4106D80 Uncharacterized protein YhaL F7D04_RS13595 ENOG4105C44 Serine transporter F7D04_RS13600 ENOG4105EJQ L-serine dehydratase F7D04_RS13605 ENOG4105KME endoribonuclease L-psp F7D04_RS13610 ENOG4105C6N Formate acetyltransferase F7D04_RS13615 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F7D04_RS13625 ENOG4105C7B Threonine dehydratase F7D04_RS13630 ENOG410811B TRANSCRIPTIONal F7D04_RS13655 ENOG4105BZW Glycerate kinase F7D04_RS13660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F7D04_RS13670 ENOG4105DJB Major Facilitator Superfamily F7D04_RS13675 ENOG4105CTX dehydratase F7D04_RS13680 ENOG4105ZEG Suppressor protein F7D04_RS13685 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression F7D04_RS13690 ENOG4105E98 transcriptional regulator DeoR family F7D04_RS13700 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB F7D04_RS13710 ENOG4105F3R pts system mannose fructose sorbose family iid F7D04_RS13715 ENOG4108YTN IIa component F7D04_RS13720 ENOG4105CE4 GlcNAc 6-P deacetylase F7D04_RS13725 ENOG4105E70 isomerase F7D04_RS13735 ENOG4108UZY PTS System F7D04_RS13740 ENOG4105ETZ PTS System F7D04_RS13745 ENOG4105F3R pts system mannose fructose sorbose family iid F7D04_RS13750 ENOG4106HBN Galactosamine-6-phosphate isomerase F7D04_RS13755 ENOG4105Q10 Fimbrial-like protein F7D04_RS13760 ENOG4108VCD Chaperone F7D04_RS13765 ENOG4105CW0 outer membrane usher protein F7D04_RS13770 ENOG4105I74 Fimbrial protein F7D04_RS13775 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F7D04_RS13780 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) F7D04_RS13785 ENOG41082RQ UPF0102 protein F7D04_RS13795 ENOG4105W4M Transport-associated protein F7D04_RS13800 ENOG4107S21 permease F7D04_RS13805 ENOG4105K4T epimerase F7D04_RS13810 ENOG4107R7Y intracellular protease Pfpi family F7D04_RS13825 ENOG4108YYD acetyltransferase F7D04_RS13845 ENOG4105DEN Luciferase family F7D04_RS13850 ENOG4105CIC tryptophan-specific transport protein F7D04_RS13855 ENOG4105C1J atp-dependent rna helicase F7D04_RS13895 ENOG4105CHV Transcription elongation factor NusA F7D04_RS13915 ENOG4105DIJ Phosphoethanolamine transferase F7D04_RS13925 ENOG4105NTZ Preprotein translocase subunit SecG F7D04_RS13935 ENOG4105EEI dihydropteroate synthase F7D04_RS13940 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F7D04_RS13950 ENOG4105HBR Rna-binding protein F7D04_RS13955 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F7D04_RS13960 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase F7D04_RS13970 ENOG4105QYV Membrane F7D04_RS13985 ENOG4105EAH synthase F7D04_RS13990 ENOG4105HVQ Regulatory factor of maltose metabolism F7D04_RS14000 ENOG4105VFK BolA family F7D04_RS14005 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane F7D04_RS14010 ENOG4105E3I toluene tolerance F7D04_RS14015 ENOG4107PE3 Mammalian cell entry related domain protein F7D04_RS14020 ENOG4105CY3 ABC transporter, permease F7D04_RS14025 ENOG4105DHJ ABC, transporter F7D04_RS14030 ENOG4105FEU K -dependent Na -Ca exchanger F7D04_RS14035 ENOG4105C2X Arabinose 5-phosphate isomerase F7D04_RS14045 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) F7D04_RS14050 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA F7D04_RS14055 ENOG4108IUZ ABC transporter F7D04_RS14060 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F7D04_RS14065 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA F7D04_RS14070 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN F7D04_RS14080 ENOG41080Z8 PHOSPHOCARRIER protein F7D04_RS14085 ENOG4108NIH transferase activity, transferring phosphorus-containing groups F7D04_RS14095 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain F7D04_RS14100 ENOG4105BZU Histidine kinase F7D04_RS14105 ENOG4105N5T Radical SAM Protein F7D04_RS14110 ENOG4105CBC glutamate synthase F7D04_RS14115 ENOG4105BZ8 glutamate synthase F7D04_RS14120 ENOG4105DFS Conserved Protein F7D04_RS14130 ENOG4108R66 Conserved Protein F7D04_RS14145 ENOG4105JHE Major Facilitator Superfamily F7D04_RS14160 ENOG4105CEE C4-dicarboxylate transporter F7D04_RS14165 ENOG4105KB2 stringent starvation protein b F7D04_RS14170 ENOG4107MKT Stringent starvation protein a F7D04_RS14185 ENOG4105D6Z AFG1 family ATPase F7D04_RS14190 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III F7D04_RS14195 ENOG4105C0H protease F7D04_RS14200 ENOG4105C0H protease F7D04_RS14215 ENOG4105RID UPF0379 protein yhcN F7D04_RS14220 ENOG4105UNR (Barnase) inhibitor F7D04_RS14235 ENOG4105ZQC membrane protein AaeX F7D04_RS14240 ENOG4105CR8 Transcriptional regulator F7D04_RS14245 ENOG4105D1U peptidase U62 modulator of DNA gyrase F7D04_RS14250 ENOG4105QD6 exported protein F7D04_RS14255 ENOG4105C03 ribonuclease F7D04_RS14265 ENOG4105VQ7 Rod shape-determining protein MreD F7D04_RS14270 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) F7D04_RS14280 ENOG41062P1 Diguanylate cyclase phosphodiesterase F7D04_RS14285 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family F7D04_RS14290 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein F7D04_RS14295 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F7D04_RS14300 ENOG4105RG0 Membrane F7D04_RS14305 ENOG4108IA2 Sodium pantothenate symporter F7D04_RS14315 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F7D04_RS14325 ENOG4105CEC DNA methylase N-4 N-6 F7D04_RS14330 ENOG41061ME transport protein F7D04_RS14335 ENOG4108XG4 DNA-binding transcriptional regulator F7D04_RS14340 ENOG4105C1P efflux transporter, rnd family, mfp subunit F7D04_RS14345 ENOG4105BZS acriflavin resistance protein F7D04_RS14350 ENOG4105XCM membrane LIPOPROTEIN F7D04_RS14360 ENOG4105EZ7 amino acid ABC transporter F7D04_RS14365 ENOG4105DRP amino acid AbC transporter F7D04_RS14370 ENOG4105CDA abc transporter atp-binding protein F7D04_RS14410 ENOG4108Z0R Transferase F7D04_RS14415 ENOG4105SG3 Protein of unknown function (DUF1488) F7D04_RS14430 ENOG4108WI1 Dna topoisomerase F7D04_RS14440 ENOG4105C79 DNA protecting protein DprA F7D04_RS14460 ENOG4105C1A potassium transporter peripheral membrane F7D04_RS14470 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system F7D04_RS14475 ENOG4105W1Y Transcriptional regulator F7D04_RS14480 ENOG4105VTS DnaJ-like, subfamily C F7D04_RS14510 ENOG41067V7 50S ribosomal protein L36 F7D04_RS14515 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F7D04_RS14560 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) F7D04_RS14605 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) F7D04_RS14630 ENOG4108UQY Iron-storage protein F7D04_RS14635 ENOG4105W53 bacterioferritin-associated ferredoxin F7D04_RS14675 ENOG4105WWK YheO domain protein F7D04_RS14680 ENOG4108V1T peptidylprolyl cis-trans isomerase F7D04_RS14690 ENOG4108YZY peptidylprolyl cis-trans isomerase F7D04_RS14695 ENOG4105VKU nucleicacid-binding protein F7D04_RS14710 ENOG4105C5H ABC transporter F7D04_RS14715 ENOG4105DNZ Alpha Beta Hydrolase F7D04_RS14725 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) F7D04_RS14730 ENOG4108UKZ OsmC family F7D04_RS14740 ENOG410613R integral membrane protein, YccS YhfK family F7D04_RS14745 ENOG4105C8Y Acetylornithine aminotransferase F7D04_RS14750 ENOG4105DDQ anthranilate synthase F7D04_RS14755 ENOG4105MZU cell filamentation protein F7D04_RS14765 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F7D04_RS14775 ENOG4107QZF nitrite reductase NADPH large subunit F7D04_RS14780 ENOG4105WZK nitrite reductase NADPH small subunit F7D04_RS14785 ENOG4107V9H nitrite transporter F7D04_RS14795 ENOG4105VYH F7D04_RS14800 ENOG4107QHQ amino acid F7D04_RS14805 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine F7D04_RS14810 ENOG4107Y0V Not clear, may be involved in an isomerization step F7D04_RS14815 ENOG4108KPW sugar kinase F7D04_RS14820 ENOG4105FDP GntR family transcriptional regulator F7D04_RS14825 ENOG4106PKC pyridoxal phosphate binding F7D04_RS14830 ENOG4106M0N transport system permease protein F7D04_RS14835 ENOG4105MUZ Protein of unknown function DUF2620 F7D04_RS14840 ENOG41080QX K07048 phosphotriesterase-related protein F7D04_RS14845 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) F7D04_RS14850 ENOG4108626 Racemase F7D04_RS14855 ENOG4105RMW regulation of transcription, DNA-dependent F7D04_RS14860 ENOG4108M21 F7D04_RS14865 ENOG4105C31 Tryptophanyl-tRNA synthetase F7D04_RS14875 ENOG4105DJV ribulose-phosphate 3-epimerase F7D04_RS14880 ENOG4105DFE Dna adenine methylase F7D04_RS14885 ENOG4105EGB membrane protein DamX F7D04_RS14900 ENOG4105E4G Type IV pilus F7D04_RS14905 ENOG4105ITY Required for the use of extracellular DNA as a nutrient F7D04_RS14910 ENOG4105XPX DNA utilization protein HofO F7D04_RS14915 ENOG41065NF Fimbrial assembly family protein F7D04_RS14920 ENOG4108U1Q Pilus assembly protein F7D04_RS14925 ENOG4108JQC penicillin-binding protein 1A F7D04_RS14930 ENOG4107RK2 ADP-ribose diphosphatase NudE F7D04_RS14935 ENOG4105DQY intracellular growth attenuator F7D04_RS14940 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 F7D04_RS14945 ENOG4105VEJ Heat shock protein F7D04_RS14955 ENOG4108MAJ Membrane F7D04_RS14965 ENOG4105E0F Histidine kinase F7D04_RS14975 ENOG4108RRZ Transcription elongation factor GreB F7D04_RS14980 ENOG4105BZM domain protein F7D04_RS14985 ENOG4105XFK Ferrous iron transport protein A F7D04_RS14990 ENOG4105CE1 Ferrous iron transport protein b F7D04_RS15000 ENOG4105DNE Transposase F7D04_RS15020 ENOG4105MJ2 Competence protein F7D04_RS15030 ENOG4105C6Z Gluconate F7D04_RS15035 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) F7D04_RS15040 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F7D04_RS15055 ENOG4105E0Y RtcB Protein F7D04_RS15060 ENOG4105CYB regulatoR F7D04_RS15065 ENOG4105E98 transcriptional regulator DeoR family F7D04_RS15080 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F7D04_RS15105 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) F7D04_RS15130 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F7D04_RS15135 ENOG41076UM multiple antibiotic resistance (MarC)-related protein F7D04_RS15140 ENOG4105C6Z Gluconate F7D04_RS15145 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family F7D04_RS15150 ENOG4105DIQ Transcriptional regulator F7D04_RS15155 ENOG4105C2I pirin domain protein F7D04_RS15160 ENOG4105D9R oxidoreductase F7D04_RS15165 ENOG4105WCN acetyltransferase F7D04_RS15170 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F7D04_RS15175 ENOG4105WC8 Conserved Protein F7D04_RS15180 ENOG4107T6V glycerophosphoryl diester phosphodiesterase F7D04_RS15190 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component F7D04_RS15195 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component F7D04_RS15200 ENOG4105BZ7 extracellular solute-binding protein family 1 F7D04_RS15205 ENOG4108IV0 ABC, transporter F7D04_RS15210 ENOG4105C0Z ABC transporter F7D04_RS15215 ENOG4105CF8 branched-chain amino acid ABC transporter, permease F7D04_RS15220 ENOG4105C32 Amino acid ABC transporter (Permease) F7D04_RS15225 ENOG4105CP9 extracellular ligand-binding receptor F7D04_RS15230 ENOG4105U59 -acetyltransferase F7D04_RS15245 ENOG4105CP9 extracellular ligand-binding receptor F7D04_RS15250 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F7D04_RS15255 ENOG4105CRP Part of the ABC transporter FtsEX involved in F7D04_RS15260 ENOG4105CAK Cell division ATP-binding protein ftsE F7D04_RS15265 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F7D04_RS15270 ENOG4106H78 methyltransferase F7D04_RS15275 ENOG4105MG3 Membrane F7D04_RS15285 ENOG4107FS9 Membrane F7D04_RS15300 ENOG4105EX9 Membrane F7D04_RS15305 ENOG4108W1V Lipoprotein F7D04_RS15310 ENOG4105F9N Major Facilitator Superfamily F7D04_RS15315 ENOG4105DSF transport protein F7D04_RS15320 ENOG4107YAK holo-(acyl carrier protein) synthase 2 F7D04_RS15325 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein F7D04_RS15330 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F7D04_RS15335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F7D04_RS15340 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) F7D04_RS15365 ENOG4105CMI transporter F7D04_RS15370 ENOG4105CJ1 ABC, transporter F7D04_RS15375 ENOG4105D0S secretion protein (HlyD F7D04_RS15390 ENOG4107UNS conserved inner membrane protein F7D04_RS15395 ENOG4105CBX hi0933 family F7D04_RS15400 ENOG4105CJ3 phosphate transporter F7D04_RS15415 ENOG4105DUX Transporter F7D04_RS15425 ENOG4105DGW oligopeptidase A F7D04_RS15430 ENOG4105D6S protein involved in catabolism of external DNA F7D04_RS15435 ENOG4105DC8 reductase F7D04_RS15450 ENOG4105KBH arsR family transcriptional regulator F7D04_RS15455 ENOG4107R5R arsenical pump membrane protein F7D04_RS15460 ENOG4105K89 arsenate reductase F7D04_RS15470 ENOG4105Y4Z Outer Membrane Lipoprotein F7D04_RS15480 ENOG4105KT7 mgtC SapB transporter F7D04_RS15485 ENOG4105XXV Acid-resistance protein F7D04_RS15490 ENOG41060V2 Acid-resistance protein F7D04_RS15495 ENOG4108YK4 Acid-resistance membrane protein F7D04_RS15500 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci F7D04_RS15510 ENOG4105C1P efflux transporter, rnd family, mfp subunit F7D04_RS15515 ENOG4105BZS acriflavin resistance protein F7D04_RS15525 ENOG4108NKV transcriptional regulator F7D04_RS15530 ENOG4105CVK Glutamate decarboxylase F7D04_RS15535 ENOG4105CA0 peroxidase F7D04_RS15545 ENOG4106S2D Transcriptional regulator F7D04_RS15550 ENOG4105CBN LysR family transcriptional regulator F7D04_RS15555 ENOG4107H3J ribonuclease F7D04_RS15560 ENOG4105CSH Transporter F7D04_RS15565 ENOG41066T0 asmA family F7D04_RS15570 ENOG4105CMB EAL domain-containing protein F7D04_RS15580 ENOG4105CS0 peptidase F7D04_RS15590 ENOG4105BZU Histidine kinase F7D04_RS15595 ENOG4105EJG cellulose synthase F7D04_RS15600 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) F7D04_RS15605 ENOG4107EEX Cellulose synthase regulator protein F7D04_RS15610 ENOG4107QZ7 Cellulose synthase catalytic subunit F7D04_RS15620 ENOG410661M cytoplasmic protein F7D04_RS15625 ENOG4105U74 cellulose biosynthesis protein BcsE F7D04_RS15630 ENOG4105WQA Cellulose biosynthesis protein BcsF F7D04_RS15635 ENOG4105D1V cellulose synthase operon protein YhjU F7D04_RS15660 ENOG4105C44 Serine transporter F7D04_RS15665 ENOG4108JQ7 (ABC) transporter F7D04_RS15670 ENOG4105C3U ABC transporter F7D04_RS15675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F7D04_RS15680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F7D04_RS15685 ENOG4105DEF Extracellular solute-binding protein, family 5 F7D04_RS15700 ENOG4105DIJ Phosphoethanolamine transferase F7D04_RS15705 ENOG4105FCD Major Facilitator F7D04_RS15710 ENOG4105EAX Putative lipase F7D04_RS15715 ENOG4108R3E Dna-3-methyladenine glycosylase i F7D04_RS15720 ENOG4105HNP -acetyltransferase F7D04_RS15725 ENOG4107QY8 reductase F7D04_RS15730 ENOG4108ZG0 Ompa motb domain protein F7D04_RS15740 ENOG4106JH6 (LipO)protein F7D04_RS15745 ENOG4105MVF Transcriptional regulator F7D04_RS15755 ENOG41060TC Hok gef cell toxic protein F7D04_RS15775 ENOG4105MEV Acyl-transferase F7D04_RS15780 ENOG4108Z12 YiaAB two helix domain-containing protein F7D04_RS15785 ENOG410688U Inner membrane protein yiaB F7D04_RS15790 ENOG4105CMG Carbohydrate kinase F7D04_RS15800 ENOG4105DFW ABC transporter F7D04_RS15805 ENOG4105C2J ABC transporter F7D04_RS15810 ENOG4108HWW ABC transporter F7D04_RS15815 ENOG4105T16 Transcriptional regulator (AraC family) F7D04_RS15820 ENOG4108UR8 BAX protein F7D04_RS15825 ENOG4107T9C Alpha amylase catalytic region F7D04_RS15830 ENOG4105JKW Valine--pyruvate aminotransferase F7D04_RS15835 ENOG4108XIB electron transport protein ysaA F7D04_RS15840 ENOG4105J4Q Transcriptional regulator F7D04_RS15850 ENOG4108R66 Conserved Protein F7D04_RS15855 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter F7D04_RS15860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit F7D04_RS15865 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit F7D04_RS15870 ENOG4105CMG Carbohydrate kinase F7D04_RS15875 ENOG4105H6Q decarboxylase F7D04_RS15880 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase F7D04_RS15885 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase F7D04_RS15895 ENOG4105GNX MltA-interacting MipA family protein F7D04_RS15900 ENOG4108Q2M Transcriptional regulator F7D04_RS15905 ENOG4105EFX secretion protein, HlyD family F7D04_RS15910 ENOG4105KK7 inner membrane protein YiaW F7D04_RS15920 ENOG4105C26 Dehydrogenase F7D04_RS15925 ENOG4105C0A alcohol dehydrogenase F7D04_RS15930 ENOG4105EM7 Selenocysteine-specific translation elongation factor F7D04_RS15940 ENOG4108U78 Glutathione S-transferase F7D04_RS15945 ENOG4105CNA YD repeat protein F7D04_RS15975 ENOG4105EFX secretion protein, HlyD family F7D04_RS15980 ENOG4105FP6 Protein of unknown function (DUF3302) F7D04_RS15985 ENOG4105CTS PTS system mannitol-specific F7D04_RS15995 ENOG4105E61 Mannitol repressor protein F7D04_RS16005 ENOG4108YYI Protein of unknown function (DUF2810) F7D04_RS16010 ENOG4108WY4 inner membrane lipoprotein F7D04_RS16015 ENOG4105EUR Domain-Containing protein F7D04_RS16020 ENOG4105DAA L-lactate F7D04_RS16025 ENOG41073TP transcriptional regulator F7D04_RS16035 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F7D04_RS16040 ENOG4105D7W serine acetyltransferase F7D04_RS16055 ENOG4105VW4 glutaredoxin 3 F7D04_RS16060 ENOG4107YZP Rhodanese domain protein F7D04_RS16070 ENOG41063SB peptidase F7D04_RS16075 ENOG4105PXI polysaccharide deacetylase F7D04_RS16080 ENOG4105K64 Glycosyl transferase, family 2 F7D04_RS16090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F7D04_RS16100 ENOG4105XA0 heptosyltransferase ii F7D04_RS16105 ENOG4105D16 lipopolysaccharide heptosyltransferase i F7D04_RS16110 ENOG41068PG O-Antigen polymerase F7D04_RS16115 ENOG4105K64 Glycosyl transferase, family 2 F7D04_RS16120 ENOG4105X1N Glycosyl transferase family 8 F7D04_RS16130 ENOG4105X1N Glycosyl transferase family 8 F7D04_RS16135 ENOG4106AH0 Glycosyl Transferase F7D04_RS16140 ENOG4107543 (lipo)polysaccharide F7D04_RS16145 ENOG4107RJ7 Glycosyl transferase (Group 1 F7D04_RS16150 ENOG4105DKP glycosyl transferase, family 9 F7D04_RS16155 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase F7D04_RS16175 ENOG4105KDC 50s ribosomal protein l28 F7D04_RS16185 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F7D04_RS16190 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) F7D04_RS16210 ENOG4105DSJ YicC domain protein F7D04_RS16215 ENOG4105F5P DNA-damage-inducible protein d F7D04_RS16220 ENOG4105EN6 Membrane F7D04_RS16230 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) F7D04_RS16240 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F7D04_RS16245 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase F7D04_RS16250 ENOG4105CB5 ATP-dependent DNA helicase recG F7D04_RS16260 ENOG4105D6U Sodium Glutamate Symporter F7D04_RS16265 ENOG4105C2W permease F7D04_RS16270 ENOG4105JV1 AsmA family F7D04_RS16275 ENOG4105CJQ hydrolase, family 31 F7D04_RS16280 ENOG4105CT4 transporter F7D04_RS16295 ENOG4105S8Q sugar efflux transporter F7D04_RS16300 ENOG4108UZ3 Transporter F7D04_RS16305 ENOG4105D01 (LipO)protein F7D04_RS16310 ENOG4105T8A Uncharacterized protein YicS F7D04_RS16320 ENOG4108SAJ Protein of unknown function (DUF1198) F7D04_RS16325 ENOG4105C7N Xanthine uracil vitamin C permease F7D04_RS16330 ENOG4105CPN adenine deaminase F7D04_RS16335 ENOG4105CXY transporter F7D04_RS16340 ENOG4105CXY transporter F7D04_RS16345 ENOG4105BZU Histidine kinase F7D04_RS16350 ENOG4108KX4 response regulator F7D04_RS16355 ENOG4105M71 acetolactate synthase 1 regulatory subunit F7D04_RS16360 ENOG4105C7K acetolactate synthase F7D04_RS16375 ENOG4105E5M Multidrug resistance protein D F7D04_RS16380 ENOG4105J13 transcriptional regulator F7D04_RS16385 ENOG4105JP4 Inner membrane protein yidG F7D04_RS16390 ENOG4105VG5 Membrane F7D04_RS16395 ENOG4106DRA Inner membrane protein YidI F7D04_RS16400 ENOG4105CBG Sulfatase F7D04_RS16410 ENOG4108AHD Transcriptional regulator F7D04_RS16420 ENOG4105CI1 PTS System F7D04_RS16425 ENOG4105FDP GntR family transcriptional regulator F7D04_RS16445 ENOG4105R2A (LipO)protein F7D04_RS16450 ENOG4105D99 atp gtp-binding protein F7D04_RS16460 ENOG4105DJB Major Facilitator Superfamily F7D04_RS16470 ENOG4108RTU Aldolase F7D04_RS16475 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 F7D04_RS16480 ENOG4105EMF GntR family transcriptional regulator F7D04_RS16485 ENOG410657R replicase EC 2.7 F7D04_RS16490 ENOG410667J hydrolase F7D04_RS16495 ENOG4105VP5 Bacterial protein of unknown function (DUF937) F7D04_RS16500 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F7D04_RS16510 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F7D04_RS16525 ENOG4105VG0 50S ribosomal protein l34 F7D04_RS16545 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) F7D04_RS16560 ENOG4108P6C Tryptophan transporter of low affinity F7D04_RS16575 ENOG4105E8Q phosphopantetheinyl transferase F7D04_RS16580 ENOG4108YYH Nadph-dependent fmn reductase F7D04_RS16585 ENOG4105C7N Xanthine uracil vitamin C permease F7D04_RS16590 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 F7D04_RS16600 ENOG4106611 bacteriocin immunity F7D04_RS16615 ENOG4107VKM 6-phosphogluconolactonase F7D04_RS16620 ENOG4105DYC esterase F7D04_RS16630 ENOG4105CS2 ec 3.2.1.21 F7D04_RS16635 ENOG4105C5Y PTS System F7D04_RS16640 ENOG4105CID antiterminator F7D04_RS16645 ENOG4108UTW Plays a role in the regulation of phosphate uptake F7D04_RS16650 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F7D04_RS16655 ENOG4105E2Z phosphate ABC transporter (Permease F7D04_RS16660 ENOG4105C8U phosphate abc transporter F7D04_RS16665 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) F7D04_RS16690 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F7D04_RS16740 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation F7D04_RS16755 ENOG4105QTB Flavodoxin F7D04_RS16760 ENOG4108VVK transcriptional Regulator, AsnC F7D04_RS16790 ENOG4105C2J ABC transporter F7D04_RS16795 ENOG4105CNN ABC, transporter F7D04_RS16800 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F7D04_RS16805 ENOG4108RVA ribokinase F7D04_RS16810 ENOG4105ETE Transcriptional regulator (LacI family F7D04_RS16815 ENOG4105C0R drug resistance transporter emrb qaca subfamily F7D04_RS16820 ENOG4107EJG GntR family transcriptional regulator F7D04_RS16860 ENOG4108WFC UPF0438 protein yifE F7D04_RS16865 ENOG4105C0P Mg chelatase subunit ChlI F7D04_RS16885 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit F7D04_RS16890 ENOG4105CM2 brancheD-chain amino acid aminotransferase F7D04_RS16900 ENOG4105C7B Threonine dehydratase F7D04_RS16905 ENOG4105EMY transcriptional regulator F7D04_RS16915 ENOG4105KQ5 peptidylprolyl cis-trans isomerase F7D04_RS16925 ENOG4105C4R Atp-dependent dna helicase F7D04_RS16950 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F7D04_RS16955 ENOG4105ESV Glycosyl transferase, family 4 F7D04_RS16960 ENOG4105SFE lipopolysaccharide biosynthesis protein F7D04_RS16965 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F7D04_RS16970 ENOG4107QQG Dehydrogenase F7D04_RS16975 ENOG4105C1B dTDP-glucose 4-6-dehydratase F7D04_RS16980 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) F7D04_RS16985 ENOG4108WJ1 acetyltransferase F7D04_RS16990 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F7D04_RS16995 ENOG4105EGZ biosynthesis protein F7D04_RS17005 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) F7D04_RS17015 ENOG4105C85 amino acid F7D04_RS17040 ENOG4105C4X radical SAM domain protein F7D04_RS17045 ENOG4105ENH Sulfatase F7D04_RS17050 ENOG410601J HemY protein F7D04_RS17055 ENOG4105ECF c-methyltransferase F7D04_RS17060 ENOG41076E6 Uroporphyrinogen-III Synthase F7D04_RS17070 ENOG4107T0K Adenylate cyclase F7D04_RS17095 ENOG4105S7Z (LipO)protein F7D04_RS17105 ENOG4105CT0 Protein of unknown function, DUF484 F7D04_RS17115 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant F7D04_RS17120 ENOG4105C4R Atp-dependent dna helicase F7D04_RS17125 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase F7D04_RS17130 ENOG4107QUT magnesium and cobalt transport protein CorA F7D04_RS17135 ENOG4105NRM Membrane F7D04_RS17140 ENOG4106WR8 Inner membrane protein YigG F7D04_RS17145 ENOG4105FR1 rard protein F7D04_RS17150 ENOG4108VUY thioesterase Superfamily protein F7D04_RS17155 ENOG4105HDD phospholipase F7D04_RS17160 ENOG4105C9U ATP-dependent DNA helicase RecQ F7D04_RS17165 ENOG4105CCF Lysine exporter protein (Lyse ygga) F7D04_RS17170 ENOG410829K Lysine exporter protein (Lyse ygga) F7D04_RS17175 ENOG4108EUD Lysophospholipase F7D04_RS17180 ENOG4105DQF Hydrolase F7D04_RS17185 ENOG4105EMK carboxylate amino acid amine transporter F7D04_RS17190 ENOG4105DZ2 Transcriptional regulator F7D04_RS17200 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) F7D04_RS17205 ENOG4108I5U Uridine phosphorylase F7D04_RS17210 ENOG4105CGY Dna recombination protein F7D04_RS17220 ENOG4105JC1 sterol-binding domain protein F7D04_RS17230 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) F7D04_RS17235 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) F7D04_RS17240 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F7D04_RS17250 ENOG4105MDZ Transcriptional activator rfaH F7D04_RS17255 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) F7D04_RS17260 ENOG4108EX3 reductase F7D04_RS17275 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F7D04_RS17285 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F7D04_RS17290 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) F7D04_RS17295 ENOG4108RR8 protoporphyrinogen oxidase F7D04_RS17325 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b F7D04_RS17330 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) F7D04_RS17335 ENOG4105PC1 Conserved Protein F7D04_RS17340 ENOG4105E27 serine threonine protein kinase F7D04_RS17345 ENOG4108Z33 Thiol disulfide Interchange Protein F7D04_RS17355 ENOG4106HNH Acyl-transferase F7D04_RS17360 ENOG4105C2M dna polymerase I F7D04_RS17375 ENOG4105D4P Coproporphyrinogen iii oxidase F7D04_RS17380 ENOG4106FIY F7D04_RS17385 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F7D04_RS17390 ENOG4105CUX Signal transduction histidine kinase F7D04_RS17395 ENOG4105C5F glutamine synthetase F7D04_RS17400 ENOG4105CI3 gtp-binding protein typa F7D04_RS17405 ENOG4108K85 Transcriptional regulator F7D04_RS17410 ENOG4108KHF Resistance protein F7D04_RS17415 ENOG4105R9B Major Facilitator F7D04_RS17420 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is F7D04_RS17425 ENOG4105CT4 transporter F7D04_RS17430 ENOG4105CJQ hydrolase, family 31 F7D04_RS17435 ENOG4107WI4 Aldose-1-epimerase F7D04_RS17440 ENOG4107QKS N-acylglucosamine 2-epimerase F7D04_RS17445 ENOG4105D2M Aldolase F7D04_RS17450 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F7D04_RS17455 ENOG4108MGF sugar kinase F7D04_RS17460 ENOG4105E98 transcriptional regulator DeoR family F7D04_RS17465 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 F7D04_RS17480 ENOG4105SUU thioesterase domain F7D04_RS17490 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system F7D04_RS17505 ENOG41068KX affects formate dehydrogenase-N F7D04_RS17520 ENOG4108MG3 formate dehydrogenase F7D04_RS17525 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F7D04_RS17540 ENOG4108V87 frv operon regulatory protein F7D04_RS17545 ENOG4106C3V frv operon regulatory protein F7D04_RS17550 ENOG4105CN9 Peptidase m42 family protein F7D04_RS17555 ENOG4105DM4 PTS System F7D04_RS17560 ENOG41064BA PTS system, fructose-specific, IIA component F7D04_RS17600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F7D04_RS17610 ENOG4108RPX mosc domain containing protein F7D04_RS17620 ENOG4105E0F Histidine kinase F7D04_RS17625 ENOG4105E3W Two component transcriptional regulator (Winged helix family F7D04_RS17630 ENOG4105FMW periplasmic F7D04_RS17635 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F7D04_RS17675 ENOG4105VZ1 Replication Protein F7D04_RS17685 ENOG4105ED4 portal protein F7D04_RS17775 ENOG4108X9F tail fiber protein F7D04_RS17780 ENOG4105UZW Tail fiber assembly protein F7D04_RS17825 ENOG4105ZTC transcriptional activator, Ogr delta F7D04_RS17840 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F7D04_RS17855 ENOG4105EBK exported protein F7D04_RS17860 ENOG4108VTS Membrane F7D04_RS17865 ENOG41065TG regulatoR F7D04_RS17875 ENOG4105DP0 ferredoxin-NADP reductase F7D04_RS17880 ENOG4105CBT Fructose-1,6-bisphosphatase F7D04_RS17890 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F7D04_RS17905 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F7D04_RS17920 ENOG41063M6 Cell Division Protein F7D04_RS17925 ENOG4105ETE Transcriptional regulator (LacI family F7D04_RS17930 ENOG4105C25 Primosomal protein n' F7D04_RS17940 ENOG4105CNA YD repeat protein F7D04_RS17955 ENOG4107S01 Repressor protein MetJ F7D04_RS17965 ENOG4105C28 cystathionine F7D04_RS17970 ENOG4105CFH Aspartokinase F7D04_RS17975 ENOG4105SYT Methylenetetrahydrofolate reductase F7D04_RS17985 ENOG4108Q5Y Membrane F7D04_RS17990 ENOG4108XC3 NADH ubiquinone oxidoreductase F7D04_RS18000 ENOG4105DCT glycerol dehydrogenase F7D04_RS18005 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F7D04_RS18010 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F7D04_RS18015 ENOG4105DM4 PTS System F7D04_RS18020 ENOG4108YRF PTS System F7D04_RS18030 ENOG4108AHH pyruvate formate lyase II activase F7D04_RS18035 ENOG4108XCZ PTS System F7D04_RS18040 ENOG4106R3P AraC family transcriptional regulator F7D04_RS18045 ENOG4105DIJ Phosphoethanolamine transferase F7D04_RS18060 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase F7D04_RS18075 ENOG4105C5Q Transcriptional regulator F7D04_RS18085 ENOG4105EJ2 Transcriptional regulator F7D04_RS18090 ENOG4108Y73 Membrane F7D04_RS18100 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F7D04_RS18105 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F7D04_RS18135 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase F7D04_RS18170 ENOG4105PM1 preprotein translocase subunit SecE F7D04_RS18175 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F7D04_RS18210 ENOG410645W Thiamin biosynthesis protein ThiH F7D04_RS18215 ENOG4105D41 biosynthesis protein thiH F7D04_RS18225 ENOG4105WHD thiamine biosynthesis protein ThiS F7D04_RS18230 ENOG4105D06 uba thif-type nad fad binding protein F7D04_RS18265 ENOG4105R2J Conserved Protein F7D04_RS18275 ENOG4108T8B Protein of unknown function (DUF1481) F7D04_RS18280 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism F7D04_RS18285 ENOG4105BZU Histidine kinase F7D04_RS18290 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F7D04_RS18295 ENOG4105C12 Phosphoribosylglycinamide synthetase F7D04_RS18325 ENOG4105K5X acetyltransferase F7D04_RS18335 ENOG4107QP3 malate synthase g F7D04_RS18340 ENOG4108I9X Isocitrate lyase F7D04_RS18355 ENOG41069M3 Transcriptional regulator F7D04_RS18360 ENOG4105C3R Methionine synthase F7D04_RS18365 ENOG4105EAM Na Pi-cotransporter F7D04_RS18375 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein F7D04_RS18380 ENOG4105F3R pts system mannose fructose sorbose family iid F7D04_RS18385 ENOG4105ETZ PTS System F7D04_RS18390 ENOG4105KPI PTS system sorbose subfamily IIB component F7D04_RS18395 ENOG4108XCU pts system F7D04_RS18400 ENOG4105CHR reductase F7D04_RS18405 ENOG4105DKT Transcriptional regulator F7D04_RS18415 ENOG4108ZR5 Conserved Protein F7D04_RS18425 ENOG410756H nucleotidyltransferase F7D04_RS18430 ENOG4108WZA zeta toxin F7D04_RS18435 ENOG4105CFH Aspartokinase F7D04_RS18450 ENOG4108MDC (LipO)protein F7D04_RS18455 ENOG4108Q9C Periplasmic Protein F7D04_RS18460 ENOG4105E3R (LipO)protein F7D04_RS18475 ENOG4107QNK )-transporter F7D04_RS18480 ENOG4105EG2 ABC transporter, permease F7D04_RS18485 ENOG4105D56 permease protein F7D04_RS18490 ENOG4107FKK extracellular solute-binding protein family 1 F7D04_RS18495 ENOG4108IJ9 (ABC) transporter F7D04_RS18505 ENOG4107W52 maltose operon periplasmic protein F7D04_RS18530 ENOG41080IJ Diacylglycerol kinase F7D04_RS18540 ENOG4107R73 Mate efflux family protein F7D04_RS18545 ENOG4105VDW Csbd family F7D04_RS18550 ENOG4105MYN Zinc uptake regulation protein F7D04_RS18560 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F7D04_RS18565 ENOG4105P4Z Phage shock protein G F7D04_RS18570 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F7D04_RS18575 ENOG4105CDU Replicative dna helicase F7D04_RS18580 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F7D04_RS18585 ENOG4105CGF Aromatic amino acid aminotransferase F7D04_RS18595 ENOG4105F0S class B acid phosphatase F7D04_RS18600 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme F7D04_RS18605 ENOG4105MSB protein, conserved in bacteria F7D04_RS18610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F7D04_RS18615 ENOG4108UUM single-stranded DNA-binding protein F7D04_RS18620 ENOG4105PMV Membrane F7D04_RS18625 ENOG4108M8H domain protein F7D04_RS18630 ENOG4108W3Q Transcriptional regulator F7D04_RS18635 ENOG4108Z4X TRANSCRIPTIONal F7D04_RS18640 ENOG4105C7N Xanthine uracil vitamin C permease F7D04_RS18645 ENOG4105EEQ Na H antiporter F7D04_RS18660 ENOG41062QD Membrane F7D04_RS18665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F7D04_RS18675 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit F7D04_RS18680 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein F7D04_RS18685 ENOG4105DVI reductase, NrfD F7D04_RS18690 ENOG4108QKW cytochrome c-type biogenesis protein F7D04_RS18700 ENOG4108W0S formate-dependent nitrite reductase complex F7D04_RS18705 ENOG4105CK2 sodium dicarboxylate symporter F7D04_RS18710 ENOG41082ND Uncharacterized protein yjcO F7D04_RS18720 ENOG4105ETP RND efflux system, outer membrane lipoprotein F7D04_RS18725 ENOG4108MI0 Resistance protein F7D04_RS18730 ENOG4105J12 Multidrug resistance protein mdtN F7D04_RS18740 ENOG4105EUZ Beta-lactamase domain protein F7D04_RS18745 ENOG4108YZG isomerase F7D04_RS18755 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein F7D04_RS18760 ENOG410849A acetyltransferase, (GNAT) family F7D04_RS18765 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) F7D04_RS18770 ENOG4105FD8 phosphonate metabolism protein PhnM F7D04_RS18775 ENOG4105HRV phosphonate c-p lyase system protein phnl F7D04_RS18780 ENOG4105ENV phosphonate C-P lyase system protein PhnK F7D04_RS18785 ENOG4105FT8 Phosphonate metabolism F7D04_RS18790 ENOG4105EKV Phosphonate metabolism protein F7D04_RS18795 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH F7D04_RS18800 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG F7D04_RS18805 ENOG4107RJJ Transcriptional regulator F7D04_RS18815 ENOG4105EHI Phosphonate ABC transporter, periplasmic F7D04_RS18820 ENOG4105D5T phosphonate abc transporter F7D04_RS18825 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase F7D04_RS18830 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F7D04_RS18835 ENOG4108F5E vimentin F7D04_RS18840 ENOG4108YIV F7D04_RS18845 ENOG4105CSH Transporter F7D04_RS18855 ENOG4105ECM Sensor protein basS pmrB F7D04_RS18860 ENOG4105XJC Two component transcriptional regulator (Winged helix family F7D04_RS18865 ENOG4105DIJ Phosphoethanolamine transferase F7D04_RS18870 ENOG4105D5Q Arginine ornithine antiporter F7D04_RS18875 ENOG4106ZGR Transcriptional regulator F7D04_RS18880 ENOG4105CXN decarboxylase F7D04_RS18885 ENOG4108K2B transcriptional regulator F7D04_RS18890 ENOG4105F8D glycoside hydrolase family 4 F7D04_RS18895 ENOG4105CT4 transporter F7D04_RS18900 ENOG4108R5S membrane F7D04_RS18905 ENOG4107GFK fumarate F7D04_RS18910 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F7D04_RS18915 ENOG4108MRH transcriptional regulatory protein F7D04_RS18925 ENOG4105VR1 Pfam:DUF1271 F7D04_RS18930 ENOG410830R acetyltransferase F7D04_RS18945 ENOG4105CRK lysyL-tRNA synthetase F7D04_RS18950 ENOG4105DUX Transporter F7D04_RS18955 ENOG4105CXN decarboxylase F7D04_RS18960 ENOG4105D5Q Arginine ornithine antiporter F7D04_RS18965 ENOG4108M3R transcriptional activator CadC F7D04_RS18995 ENOG4105CDU Replicative dna helicase F7D04_RS19040 ENOG4105GNX MltA-interacting MipA family protein F7D04_RS19050 ENOG4108IYH Dna topoisomerase F7D04_RS19065 ENOG4108UUM single-stranded DNA-binding protein F7D04_RS19070 ENOG4105DNE Transposase F7D04_RS19305 ENOG4105TNG K13735 adhesin invasin F7D04_RS19310 ENOG41088T4 Helicase IV F7D04_RS19330 ENOG4108SIC Transcriptional regulator F7D04_RS19345 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F7D04_RS19350 ENOG4108IJ0 Aspartate ammonia-lyase F7D04_RS19355 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 F7D04_RS19360 ENOG4105DVH amino acid F7D04_RS19375 ENOG4108ZVF (LipO)protein F7D04_RS19380 ENOG4105MTB Uncharacterized protein YjeJ F7D04_RS19385 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F7D04_RS19395 ENOG4107PEH Entericidin EcnA/B family F7D04_RS19400 ENOG4106BSU Entericidin B F7D04_RS19405 ENOG4105KPY Small multidrug resistance protein F7D04_RS19410 ENOG4105QNF Outer membrane lipoprotein F7D04_RS19415 ENOG41066YJ Beta-lactamase F7D04_RS19430 ENOG4105E33 succinate dehydrogenase F7D04_RS19435 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F7D04_RS19445 ENOG4107SC7 Inner membrane transporter yjeM F7D04_RS19450 ENOG4105EGS Mechanosensitive ion channel F7D04_RS19490 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F7D04_RS19495 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) F7D04_RS19500 ENOG4105K8N protein family UPF0079, ATPase F7D04_RS19505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F7D04_RS19525 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F7D04_RS19530 ENOG4107QJR hflk protein F7D04_RS19535 ENOG4105EPW hflc protein F7D04_RS19555 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F7D04_RS19560 ENOG4105C2N RNA methyltransferase TrmH family group 3 F7D04_RS19565 ENOG4105FUX Conserved Protein F7D04_RS19570 ENOG4108P9J Phage shock protein A F7D04_RS19575 ENOG4107VNS Protein of unknown function (DUF2491) F7D04_RS19580 ENOG4105Z6B inner membrane protein yjfl F7D04_RS19585 ENOG4108KXT Conserved Protein F7D04_RS19590 ENOG4106032 Glutathionylspermidine synthase F7D04_RS19595 ENOG4105CSU acyl-Coa dehydrogenase F7D04_RS19600 ENOG4105S17 UPF0379 protein yjfN F7D04_RS19605 ENOG4105WSB biofilm stress and motility protein A F7D04_RS19610 ENOG4108MXZ Esterase F7D04_RS19625 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC F7D04_RS19630 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport F7D04_RS19655 ENOG4105KIT UPF0379 protein yjfY F7D04_RS19670 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) F7D04_RS19695 ENOG4105D7V transposase F7D04_RS19705 ENOG4105FHY Opacity-associated protein A F7D04_RS19710 ENOG4108V1T peptidylprolyl cis-trans isomerase F7D04_RS19715 ENOG4105C85 amino acid F7D04_RS19735 ENOG4105DXC membrane F7D04_RS19740 ENOG4105ECR NmrA family F7D04_RS19745 ENOG4105KVH Transcriptional regulator F7D04_RS19750 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic F7D04_RS19755 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase F7D04_RS19760 ENOG4108UUE Transcriptional regulator F7D04_RS19765 ENOG41061GZ Protein of unknown function (DUF1107) F7D04_RS19770 ENOG4105C37 (CBS) domain F7D04_RS19785 ENOG4105CFU surface antigen F7D04_RS19790 ENOG4105MA0 exported protein F7D04_RS19795 ENOG4108ZHD aig2 family F7D04_RS19800 ENOG41087RY SpoVT_AbrB F7D04_RS19805 ENOG4105MZG transcriptional modulator of maze toxin, mazf F7D04_RS19810 ENOG4105F0N pyrophosphate phospho-hydrolase F7D04_RS19815 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator F7D04_RS19820 ENOG4105C2J ABC transporter F7D04_RS19825 ENOG4107R9N ABC transporter F7D04_RS19830 ENOG41062B0 ABC transporter, permease F7D04_RS19840 ENOG4105DFU Cell wall formation (By similarity) F7D04_RS19850 ENOG4105CMS peptidase U62, modulator of DNA gyrase F7D04_RS19860 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) F7D04_RS19865 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase F7D04_RS19870 ENOG4105CG3 alpha amylase, catalytic region F7D04_RS19875 ENOG4105C5Y PTS System F7D04_RS19880 ENOG4105D4X repressor F7D04_RS19890 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F7D04_RS19895 ENOG4105KME endoribonuclease L-psp F7D04_RS19910 ENOG4107C93 pyrBI operon leader peptide F7D04_RS19915 ENOG4108UQ8 endoribonuclease L-psp F7D04_RS19920 ENOG4105F6U Short-chain dehydrogenase reductase Sdr F7D04_RS19925 ENOG4108XFH Transcriptional regulator F7D04_RS19930 ENOG4105XEP YhcH YjgK YiaL family protein F7D04_RS19950 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) F7D04_RS19955 ENOG4108MJ3 acetyltransferase F7D04_RS19960 ENOG4108M3P Membrane F7D04_RS19965 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F7D04_RS19970 ENOG4105MYG DNA polymerase iii, chi subunit F7D04_RS19980 ENOG4108M8S permease YjgP YjgQ family protein F7D04_RS19985 ENOG4108K5H permease YjgP YjgQ family protein F7D04_RS19990 ENOG4105D7A ATP-binding protein F7D04_RS19995 ENOG4105DQ4 alcohol dehydrogenase F7D04_RS20155 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) F7D04_RS20160 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria F7D04_RS20165 ENOG4108W9T type 1 fimbriae regulatory protein F7D04_RS20170 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off F7D04_RS20180 ENOG4108S54 Fimbrial protein F7D04_RS20185 ENOG4108NAE Fimbrial chaperone protein F7D04_RS20190 ENOG4105CW0 outer membrane usher protein F7D04_RS20195 ENOG4108SQA Fimbrial F7D04_RS20200 ENOG4108T65 Fimbrial F7D04_RS20205 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin F7D04_RS20210 ENOG4107EFN gluconate transport system permease 3 F7D04_RS20220 ENOG4105DEI Mannitol dehydrogenase F7D04_RS20225 ENOG4105C6F GntR Family Transcriptional Regulator F7D04_RS20245 ENOG4107YNJ LysR family Transcriptional regulator F7D04_RS20250 ENOG4105DYB Isoaspartyl dipeptidase F7D04_RS20255 ENOG4108P2H Inner membrane protein YjiG F7D04_RS20260 ENOG41074DU domain protein F7D04_RS20270 ENOG4105CBP Major Facilitator F7D04_RS20285 ENOG4105CIZ coA-substrate-specific enzyme activase F7D04_RS20290 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase F7D04_RS20295 ENOG4106BRA Membrane F7D04_RS20300 ENOG41083G8 Multidrug resistance protein MdtM F7D04_RS20315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F7D04_RS20320 ENOG4106DIZ Domain of unknown function (DUF1127) F7D04_RS20330 ENOG4105CKI cobalamin synthesis protein F7D04_RS20335 ENOG4105VCD cytoplasmic protein F7D04_RS20340 ENOG4105D22 carbon starvation protein F7D04_RS20345 ENOG4107UWN reductase F7D04_RS20350 ENOG4105EFA 4-hydroxyphenylacetate F7D04_RS20365 ENOG4105CNV Aldolase F7D04_RS20380 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase F7D04_RS20385 ENOG4105C26 Dehydrogenase F7D04_RS20390 ENOG4105ERH Fumarylacetoacetate hydrolase F7D04_RS20395 ENOG4108V8F Transcriptional regulator, MarR family F7D04_RS20400 ENOG4105C8Q Methyl-accepting chemotaxis F7D04_RS20405 ENOG4108I5G Major Facilitator superfamily F7D04_RS20410 ENOG410617M Transcriptional regulator F7D04_RS20415 ENOG4105CPQ Dehydrogenase F7D04_RS20425 ENOG4105RI1 glycoprotein receptor F7D04_RS20430 ENOG4106CVF DNA replication protein F7D04_RS20440 ENOG4107XM3 UPF0442 protein F7D04_RS20445 ENOG4105DWK Membrane F7D04_RS20450 ENOG4108N8T regulatoR F7D04_RS20455 ENOG4108T94 DNA-binding transcriptional activator BglJ F7D04_RS20460 ENOG4108819 ferric iron reductase F7D04_RS20465 ENOG4105YBH Protein of unknown function (DUF1435) F7D04_RS20485 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) F7D04_RS20490 ENOG4108WPU DNA polymerase III subunit psi F7D04_RS20495 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F7D04_RS20500 ENOG4105PAD Hydrolase F7D04_RS20520 ENOG41077V0 CPS-53 (KpLE1) prophage F7D04_RS20525 ENOG4108R7K Metal Dependent Phosphohydrolase F7D04_RS20530 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) F7D04_RS20535 ENOG4105H40 F7D04_RS20540 ENOG4105RDA repressor F7D04_RS20545 ENOG41078CG DNA-binding transcriptional regulator F7D04_RS20550 ENOG4108S1U F7D04_RS20585 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) F7D04_RS20595 ENOG4108MXB Protein of unknown function (DUF968) F7D04_RS20600 ENOG4105HRS Antitermination protein F7D04_RS20615 ENOG4105QFS Lysis protein S homolog from lambdoid prophage F7D04_RS20665 ENOG4105EFC phage portal protein HK97 family F7D04_RS20750 ENOG4105PI0 Ferredoxin F7D04_RS20770 ENOG4106FE3 DNA repair F7D04_RS20780 ENOG4105K3G Periplasmic Protein F7D04_RS20790 ENOG4108NRW Phospholipase, patatin family F7D04_RS20795 ENOG4105EYA deoxyribonuclease F7D04_RS20800 ENOG41076CZ activating enzyme F7D04_RS20805 ENOG4105G0K glycine radical enzyme YjjI family F7D04_RS20840 ENOG41062Z9 Membrane F7D04_RS20845 ENOG4105EAC phosphoserine phosphatase F7D04_RS20850 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F7D04_RS20855 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase F7D04_RS20860 ENOG4105C5H ABC transporter F7D04_RS20865 ENOG4107SC1 transglycosylase F7D04_RS20875 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F7D04_RS20885 ENOG4105UEI Transcriptional Regulator AraC Family F7D04_RS20890 ENOG4108RH0 Crea protein F7D04_RS20895 ENOG4105E3W Two component transcriptional regulator (Winged helix family F7D04_RS20900 ENOG4105EB3 Histidine kinase F7D04_RS20905 ENOG4105CT7 inner membrane cred family protein F7D04_RS20910 ENOG41065U4 response regulator F7D04_RS20915 ENOG410759A F7D04_RS20920 ENOG4106FVC RNA methyltransferase F7D04_RS20930 ENOG4105CFH Aspartokinase F7D04_RS20940 ENOG4105D98 threonine synthase F7D04_RS20945 ENOG41062C6 Protein of unknown function (DUF2502) F7D04_RS20955 ENOG4105BZG amino acid carrier protein F7D04_RS20960 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F7D04_RS20965 ENOG4108RIR Molybdenum cofactor biosynthesis protein F7D04_RS20970 ENOG4106HK8 GPR1 FUN34 yaaH family protein F7D04_RS20975 ENOG4108QUJ UPF0174 protein YaaW F7D04_RS20995 ENOG4105WI6 cell killing protein encoded within cryptic prophage F7D04_RS21005 ENOG41063Z6 transcriptional regulator, lysR family F7D04_RS21030 ENOG410647N response to DNA damage stimulus F7D04_RS21035 ENOG4105DTN riboflavin biosynthesis protein ribF F7D04_RS21040 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F7D04_RS21045 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) F7D04_RS21050 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase F7D04_RS21070 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain F7D04_RS21075 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F7D04_RS21080 ENOG4108XNW Transcriptional activatory protein CaiF F7D04_RS21090 ENOG4106YT9 Enoyl-CoA hydratase F7D04_RS21120 ENOG4105C10 Electron transfer flavoprotein F7D04_RS21125 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase F7D04_RS21130 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein F7D04_RS21135 ENOG4105C54 Major Facilitator superfamily F7D04_RS21150 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) F7D04_RS21175 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) F7D04_RS21180 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) F7D04_RS21185 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) F7D04_RS21190 ENOG4105D3G Pseudouridine synthase F7D04_RS21195 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) F7D04_RS21200 ENOG4105CQ2 DNA polymerase F7D04_RS21205 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase F7D04_RS21215 ENOG4105EF1 ribulokinase F7D04_RS21220 ENOG41063TF transcriptional regulator (AraC F7D04_RS21225 ENOG4108KF1 Membrane F7D04_RS21240 ENOG4106SMU thiamine transporter membrane protein F7D04_RS21245 ENOG4105DP9 ABC transporter F7D04_RS21260 ENOG4105S8Q sugar efflux transporter F7D04_RS21275 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F7D04_RS21290 ENOG41064T2 transcriptional regulator, lysR family F7D04_RS21295 ENOG4105C7K acetolactate synthase F7D04_RS21300 ENOG4108ZP8 Acetolactate synthase small subunit F7D04_RS21310 ENOG4107B7Y DNA-binding transcriptional regulator FruR F7D04_RS21325 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F7D04_RS21330 ENOG4105CJN penicillin-binding protein F7D04_RS21335 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F7D04_RS21340 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) F7D04_RS21355 ENOG4105CNI cell division protein FtsW F7D04_RS21365 ENOG4105DFU Cell wall formation (By similarity) F7D04_RS21370 ENOG4105CPF Cell wall formation (By similarity) F7D04_RS21375 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) F7D04_RS21380 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F7D04_RS21385 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F7D04_RS21395 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) F7D04_RS21405 ENOG4105M6F mutator MutT protein F7D04_RS21420 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F7D04_RS21430 ENOG4105D7Q type ii secretion system F7D04_RS21435 ENOG4107QHF type ii secretion system protein e F7D04_RS21440 ENOG4108ZUW Major pilin subunit F7D04_RS21445 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F7D04_RS21450 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F7D04_RS21455 ENOG4106A72 regulatory protein AmpE F7D04_RS21460 ENOG4105C85 amino acid F7D04_RS21465 ENOG41073TP transcriptional regulator F7D04_RS21470 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F7D04_RS21475 ENOG4107QSN dihydrolipoamide acetyltransferase F7D04_RS21480 ENOG4107QN2 dihydrolipoyl dehydrogenase F7D04_RS21485 ENOG4108NST exported protein F7D04_RS21490 ENOG4107QIJ Aconitate hydratase 2 F7D04_RS21510 ENOG4108ZRK uncharacterized protein yacC F7D04_RS21515 ENOG4105E3B Multicopper oxidase F7D04_RS21520 ENOG4105DZG Dehydrogenase F7D04_RS21525 ENOG4108UGV hypoxanthine phosphoribosyltransferase F7D04_RS21530 ENOG41077A9 carbonic anhydrase F7D04_RS21535 ENOG4105DA5 (ABC) transporter F7D04_RS21540 ENOG4105E3A (ABC) transporter F7D04_RS21545 ENOG4108YTN IIa component F7D04_RS21550 ENOG4107BJW polysaccharide deacetylase F7D04_RS21560 ENOG4108A32 Transposase F7D04_RS21575 ENOG4105P0Q fimbrial-like protein YadC F7D04_RS21585 ENOG4105SYG Fimbrial protein F7D04_RS21595 ENOG4105CW0 outer membrane usher protein F7D04_RS21600 ENOG4108VEV chaperone F7D04_RS21610 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F7D04_RS21615 ENOG4105DJ0 Poly(A) Polymerase F7D04_RS21635 ENOG4107XID 2'-5' rna ligase F7D04_RS21640 ENOG4105CQ7 ATP-dependent helicase F7D04_RS21645 ENOG4105BZ4 penicillin-binding protein F7D04_RS21650 ENOG4105E0K tonB-dependent siderophore receptor F7D04_RS21655 ENOG4105E0A ABC, transporter F7D04_RS21660 ENOG4105J76 Periplasmic binding protein F7D04_RS21665 ENOG4105S6R Iron-hydroxamate transporter permease subunit F7D04_RS21690 ENOG4105EN6 Membrane F7D04_RS21695 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) F7D04_RS21710 ENOG4105C0H protease F7D04_RS21715 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR F7D04_RS21735 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F7D04_RS21760 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F7D04_RS21765 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F7D04_RS21770 ENOG4105KNE Phosphatidate cytidylyltransferase F7D04_RS21775 ENOG4105DZP Membrane-associated zinc metalloprotease F7D04_RS21785 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) F7D04_RS21790 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F7D04_RS21815 ENOG4105C0B DNA polymerase III (alpha subunit) F7D04_RS21825 ENOG4105CXN decarboxylase F7D04_RS21830 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F7D04_RS21835 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F7D04_RS21840 ENOG4105M1T rho-binding antiterminator F7D04_RS21850 ENOG4108VWS Yaeq family F7D04_RS21855 ENOG4108YZN class I peptide chain release factor F7D04_RS21860 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion F7D04_RS21865 ENOG4108UY0 (LipO)protein F7D04_RS21875 ENOG4108R96 Methyltransferase, YaeB family F7D04_RS21880 ENOG4108R8X outer membrane lipoprotein F7D04_RS21885 ENOG4105D01 (LipO)protein F7D04_RS21890 ENOG4108UMI ABC transporter, permease F7D04_RS21895 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F7D04_RS21900 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F7D04_RS21935 ENOG4105CV8 reductase F7D04_RS21965 ENOG4105F2W methyltransferase F7D04_RS21970 ENOG4105E9H Lytic Murein transglycosylase F7D04_RS21980 ENOG4105D1A Methyltransferase F7D04_RS21990 ENOG4107RZZ dna polymerase iii epsilon subunit F7D04_RS22000 ENOG410600K aminopeptidase F7D04_RS22015 ENOG4105GMB type VI secretion system effector, hcp1 family F7D04_RS22040 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F7D04_RS22095 ENOG4108WC9 type VI secretion system effector, hcp1 family F7D04_RS22100 ENOG4105CS6 Rhs element vgr protein F7D04_RS22105 ENOG4105CNA YD repeat protein F7D04_RS22120 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F7D04_RS22125 ENOG4108WN0 inhibitor of vertebrate lysozyme F7D04_RS22130 ENOG4107QPN acyl-Coa dehydrogenase F7D04_RS22140 ENOG4105E7A Glutamine amidotransferase F7D04_RS22145 ENOG4105F7V ErfK ybiS ycfS ynhG family protein F7D04_RS22150 ENOG4108YS0 lipoprotein YafL F7D04_RS22155 ENOG4108UK5 Transposase F7D04_RS22170 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F7D04_RS22175 ENOG4108HYG acetyltransferase F7D04_RS22185 ENOG4108S2Y peptide Chain Release factor F7D04_RS22190 ENOG4105CIN aminoacyl-histidine dipeptidase F7D04_RS22200 ENOG4105V1F Fermentation respiration switch protein F7D04_RS22210 ENOG4105FCK Membrane F7D04_RS22230 ENOG4105DFP Integrase F7D04_RS22295 ENOG4107XAN XdhC and CoxI family F7D04_RS22300 ENOG4105C7W Xanthine dehydrogenase F7D04_RS22305 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding F7D04_RS22310 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit F7D04_RS22320 ENOG4105PI0 Ferredoxin F7D04_RS22330 ENOG4106PYX Receptor F7D04_RS22335 ENOG4108N3D putative enzyme F7D04_RS22390 ENOG4108KBJ Inner membrane protein YkgB F7D04_RS22395 ENOG41066GK UPF0379 protein ykgI F7D04_RS22400 ENOG4107QN2 dihydrolipoyl dehydrogenase F7D04_RS22405 ENOG4108K01 transcriptional regulator F7D04_RS22410 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F7D04_RS22415 ENOG4107QR9 Iron-sulfur cluster binding protein F7D04_RS22420 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) F7D04_RS22445 ENOG4105C94 Transporter F7D04_RS22455 ENOG4105BZU Histidine kinase F7D04_RS22460 ENOG4108NUU Transcriptional regulator F7D04_RS22465 ENOG4105SZ2 membrAne F7D04_RS22470 ENOG4107SNB ankyrin repeat protein YahD F7D04_RS22475 ENOG4105N16 Protein of unknown function (DUF2877) F7D04_RS22480 ENOG4107R1Q Membrane protein FdrA F7D04_RS22485 ENOG4107REC cytoplasmic protein F7D04_RS22490 ENOG4105C5B carbamate kinase F7D04_RS22495 ENOG4105DZC cytosine deaminase F7D04_RS22500 ENOG4105DQ4 alcohol dehydrogenase F7D04_RS22515 ENOG4105E82 cytochrome subunit of dehydrogenase F7D04_RS22520 ENOG4105TDT uncharacterized protein yahO F7D04_RS22525 ENOG4108JU7 Transcriptional regulator F7D04_RS22530 ENOG4105CR4 methylisocitrate lyase F7D04_RS22535 ENOG4105BZN citrate synthase F7D04_RS22540 ENOG4105DXD 2-methylcitrate dehydratase F7D04_RS22545 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F7D04_RS22550 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin F7D04_RS22555 ENOG4105DZC cytosine deaminase F7D04_RS22560 ENOG4105DND Transcriptional regulator F7D04_RS22565 ENOG4107B2H carbonic anhydrase F7D04_RS22575 ENOG4105DJ2 Major Facilitator Superfamily F7D04_RS22580 ENOG4108UW5 maltose o-acetyltransferase F7D04_RS22585 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) F7D04_RS22595 ENOG4105ETE Transcriptional regulator (LacI family F7D04_RS22600 ENOG4108K2P TRANSCRIPTIONal F7D04_RS22635 ENOG4108SC4 )-transporter F7D04_RS22640 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme F7D04_RS22650 ENOG4105C4W S-formylglutathione hydrolase F7D04_RS22665 ENOG4105SRB Uncharacterized protein yaiO F7D04_RS22675 ENOG4108PBI Polysaccharide metabolism F7D04_RS22680 ENOG4107W19 lmbE family F7D04_RS22685 ENOG4106FTQ Taurine ABC transporter, periplasmic F7D04_RS22695 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F7D04_RS22700 ENOG4105E2B Taurine dioxygenase F7D04_RS22705 ENOG4105D52 delta-aminolevulinic acid dehydratase F7D04_RS22715 ENOG4108PNB DNA-binding transcriptional regulator F7D04_RS22720 ENOG4107R6D beta-lactam binding protein AmpH F7D04_RS22725 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 F7D04_RS22730 ENOG4107QS8 (LipO)protein F7D04_RS22735 ENOG4105FR5 inner membrane protein YaiY F7D04_RS22740 ENOG4105UNH Membrane F7D04_RS22745 ENOG4105CPF Cell wall formation (By similarity) F7D04_RS22760 ENOG4105G6Z alkaline phosphatase F7D04_RS22765 ENOG4105VIF phosphate starvation-inducible protein F7D04_RS22770 ENOG4105BZU Histidine kinase F7D04_RS22775 ENOG4105II7 pyrroline-5-carboxylate reductase F7D04_RS22790 ENOG4105SS3 F7D04_RS22795 ENOG4105HBA AroM protein F7D04_RS22815 ENOG4105DKQ ROK family F7D04_RS22820 ENOG4105F27 Major Facilitator F7D04_RS22825 ENOG4105EYH Exonuclease F7D04_RS22830 ENOG4107RH8 nuclease SbcCD subunit D F7D04_RS22835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F7D04_RS22840 ENOG4105BZU Histidine kinase F7D04_RS22845 ENOG4105CWM branched-chain amino acid transport system II carrier protein F7D04_RS22850 ENOG4105C85 amino acid F7D04_RS22855 ENOG4107R28 alpha amylase, catalytic region F7D04_RS22875 ENOG4105VIE preprotein translocase, subunit YajC F7D04_RS22880 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F7D04_RS22885 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F7D04_RS22890 ENOG4105N1F Hnh endonuclease F7D04_RS22895 ENOG4105DRB nucleoside-specific channel-forming protein F7D04_RS22900 ENOG4108KIC (LipO)protein F7D04_RS22910 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F7D04_RS22915 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) F7D04_RS22925 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) F7D04_RS22930 ENOG4108ZAI phosphatidylglycerophosphatase a F7D04_RS22935 ENOG4105CPC Aldo Keto reductase F7D04_RS22945 ENOG4105CTB Polyprenyl synthetase F7D04_RS22960 ENOG4107S0N DJ-1 family F7D04_RS22965 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F7D04_RS22975 ENOG4107RDB Major Facilitator F7D04_RS23000 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) F7D04_RS23005 ENOG4105CCU oxidase (Subunit III) F7D04_RS23010 ENOG4105BZ9 Cytochrome C oxidase, subunit I F7D04_RS23015 ENOG4105E2S oxidase) subunit II F7D04_RS23020 ENOG4105EYM Major Facilitator superfamily F7D04_RS23025 ENOG4105IEY (LipO)protein F7D04_RS23030 ENOG4105M85 Bola protein F7D04_RS23050 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) F7D04_RS23055 ENOG4105K70 DNA-binding protein F7D04_RS23060 ENOG4105EIN peptidylprolyl cis-trans isomerase F7D04_RS23065 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein F7D04_RS23070 ENOG4108TGP Thioesterase superfamily protein F7D04_RS23080 ENOG4108NFA extracellular solute-binding protein F7D04_RS23090 ENOG4108XM1 transcriptional regulator AsnC family F7D04_RS23095 ENOG4105BZ1 (ABC) transporter F7D04_RS23100 ENOG4105BZ1 (ABC) transporter F7D04_RS23105 ENOG4108YZA Nitrogen regulatory protein pii F7D04_RS23110 ENOG4105BZU Histidine kinase F7D04_RS23115 ENOG4105C29 acyl-CoA thioesterase F7D04_RS23120 ENOG4108MNP Glycoprotein polysaccharide metabolism F7D04_RS23125 ENOG41080UX Methyltransferase F7D04_RS23135 ENOG4105KCV RNA signal recognition particle 4.5S RNA F7D04_RS23140 ENOG41066DG (EAL) domain protein F7D04_RS23145 ENOG4105GSJ Inner membrane protein ylaC F7D04_RS23150 ENOG4108UW5 maltose o-acetyltransferase F7D04_RS23155 ENOG4105KF5 hemolysin expression-modulating protein F7D04_RS23160 ENOG4108UKR Biofilm formation regulator YbaJ F7D04_RS23165 ENOG4105BZS acriflavin resistance protein F7D04_RS23170 ENOG4105C1P efflux transporter, rnd family, mfp subunit F7D04_RS23175 ENOG4107XI7 Tetr family transcriptional regulator F7D04_RS23180 ENOG4105EGS Mechanosensitive ion channel F7D04_RS23185 ENOG4106428 Protein of unknown function (DUF2496) F7D04_RS23190 ENOG4108URS primosomal replication protein n'' F7D04_RS23195 ENOG4105WD1 Membrane F7D04_RS23205 ENOG4107QMP dna polymerase iii subunits gamma and tau F7D04_RS23240 ENOG4107RE1 Inosine-guanosine kinase F7D04_RS23245 ENOG4105CKD glutathione-regulated potassium-efflux system protein F7D04_RS23250 ENOG4105EU0 Major facilitator Superfamily F7D04_RS23255 ENOG4105CGH 5'-nucleotidase F7D04_RS23260 ENOG4108Z66 YbaK ebsC protein F7D04_RS23265 ENOG4105MBR gumn family F7D04_RS23270 ENOG41081XE plasmid maintenance system antidote protein, xre family F7D04_RS23275 ENOG4105C59 p-type ATPase F7D04_RS23280 ENOG4105CSV Glutaminase F7D04_RS23285 ENOG4107RY6 amino acid F7D04_RS23290 ENOG4108Z6Z Transcriptional regulator F7D04_RS23295 ENOG4105G5H Membrane F7D04_RS23300 ENOG4107QX8 SPFH domain, Band 7 family protein F7D04_RS23305 ENOG41083J0 (ABC) transporter F7D04_RS23310 ENOG4105C4B ABC transporter, permease F7D04_RS23320 ENOG4105E1F short-chain dehydrogenase reductase F7D04_RS23325 ENOG4108UJV acyl-CoA thioesterase i F7D04_RS23330 ENOG4108I0Y (ABC) transporter F7D04_RS23335 ENOG4105CV6 ABC transporter, permease F7D04_RS23345 ENOG4107653 Transcriptional regulator F7D04_RS23355 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region F7D04_RS23360 ENOG41060W2 glyoxylate carboligase F7D04_RS23365 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) F7D04_RS23370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F7D04_RS23375 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease F7D04_RS23385 ENOG4105DTE Xanthine uracil vitamin C permease F7D04_RS23390 ENOG4105BZW Glycerate kinase F7D04_RS23395 ENOG4105S0E allantoin catabolism protein F7D04_RS23400 ENOG4105CE7 Amidase, hydantoinase carbamoylase family F7D04_RS23410 ENOG4107R1Q Membrane protein FdrA F7D04_RS23415 ENOG4107REC cytoplasmic protein F7D04_RS23420 ENOG4105G5A Protein of unknown function (DUF2877) F7D04_RS23425 ENOG4105C5B carbamate kinase F7D04_RS23430 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F7D04_RS23435 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F7D04_RS23445 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) F7D04_RS23455 ENOG4105S2T inner membrane protein YbcI F7D04_RS23460 ENOG4105WQ3 Rna-binding protein F7D04_RS23465 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F7D04_RS23470 ENOG4108WDE Fimbrial protein F7D04_RS23475 ENOG4108AF8 Chaperone F7D04_RS23480 ENOG4105CW0 outer membrane usher protein F7D04_RS23485 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) F7D04_RS23490 ENOG4108ZI2 Fimbrial protein F7D04_RS23495 ENOG4108Q9V regulatoR F7D04_RS23505 ENOG4108KU3 Integrase F7D04_RS23520 ENOG4108R7K Metal Dependent Phosphohydrolase F7D04_RS23525 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) F7D04_RS23530 ENOG4105H40 F7D04_RS23555 ENOG4108S1U F7D04_RS23595 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) F7D04_RS23605 ENOG4108MXB Protein of unknown function (DUF968) F7D04_RS23610 ENOG4105HRS Antitermination protein F7D04_RS23620 ENOG4105QFS Lysis protein S homolog from lambdoid prophage F7D04_RS23625 ENOG4105KUS lysozyme F7D04_RS23635 ENOG4105QYK bacteriophage lambda Bor protein homolog F7D04_RS23650 ENOG4106YSC F7D04_RS23655 ENOG4105FKG DNA packaging protein F7D04_RS23660 ENOG4105UZW Tail fiber assembly protein F7D04_RS23665 ENOG4107DE1 head-to-tail joining protein F7D04_RS23675 ENOG4105F7J membrane-bound serine protease F7D04_RS23685 ENOG4105IM0 capsid protein F7D04_RS23760 ENOG4108X9F tail fiber protein F7D04_RS23770 ENOG4105WEF catalase F7D04_RS23775 ENOG4108N8X transition metal ion binding F7D04_RS23780 ENOG4108Z9Z response to DNA damage stimulus F7D04_RS23790 ENOG4108WF3 methyltransferase F7D04_RS23805 ENOG4108NC2 Outer membrane protease F7D04_RS23815 ENOG4105K5X acetyltransferase F7D04_RS23825 ENOG4105QUW F7D04_RS23830 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit F7D04_RS23835 ENOG410802X bacteriophage n4 adsorption protein b F7D04_RS23840 ENOG410600T transposase F7D04_RS23855 ENOG4105CNA YD repeat protein F7D04_RS23865 ENOG4105CS6 Rhs element vgr protein F7D04_RS23870 ENOG4105GR3 Histidine kinase F7D04_RS23875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F7D04_RS23880 ENOG4105ENJ RND efflux system, outer membrane lipoprotein F7D04_RS23885 ENOG410624V efflux system protein F7D04_RS23890 ENOG4105EP1 Efflux transporter rnd family, mfp subunit F7D04_RS23895 ENOG4108IJF Heavy metal efflux pump, CzcA F7D04_RS23900 ENOG4105C85 amino acid F7D04_RS23905 ENOG4105CUY Mechanosensitive ion channel F7D04_RS23910 ENOG4108RCM Nitroreductase F7D04_RS23915 ENOG4105MSB protein, conserved in bacteria F7D04_RS23920 ENOG4105WQ6 Membrane F7D04_RS23925 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) F7D04_RS23930 ENOG4107635 Hok Gef family protein F7D04_RS23935 ENOG4108TSE Transferase F7D04_RS23940 ENOG4107RNH Outer membrane receptor FepA F7D04_RS23945 ENOG4105E93 esterase F7D04_RS23950 ENOG41085A6 mbth domain-containing protein F7D04_RS23955 ENOG4105C0W non-ribosomal peptide synthetase F7D04_RS23960 ENOG4108QY5 Ferric enterobactin transport protein F7D04_RS23965 ENOG4105E0A ABC, transporter F7D04_RS23970 ENOG4105TVJ transport system, permease F7D04_RS23975 ENOG4105DQ5 transport system permease protein F7D04_RS23985 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein F7D04_RS23990 ENOG4105E4F Isochorismate synthase F7D04_RS23995 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F7D04_RS24000 ENOG4105WQI isochorismatase F7D04_RS24005 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F7D04_RS24010 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) F7D04_RS24015 ENOG4105D22 carbon starvation protein F7D04_RS24020 ENOG4105VCD cytoplasmic protein F7D04_RS24025 ENOG4107SCQ Iron-containing alcohol dehydrogenase F7D04_RS24030 ENOG4105CHM Aminotransferase F7D04_RS24035 ENOG4105GTN ParB Domain Protein Nuclease F7D04_RS24040 ENOG4105BZV Phosphoadenosine phosphosulfate reductase F7D04_RS24045 ENOG4105DQS Transcriptional regulator F7D04_RS24050 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase F7D04_RS24055 ENOG4105D3R alkyl hydroperoxide reductase F7D04_RS24060 ENOG4108JU3 Alkyl hydroperoxide reductase F7D04_RS24065 ENOG4108U51 Universal stress protein F7D04_RS24070 ENOG4105E2A Dehydrogenase F7D04_RS24075 ENOG4105NXH GreA GreB family elongation factor F7D04_RS24080 ENOG4105KTS ribonuclease F7D04_RS24085 ENOG4107QPK )-transporter F7D04_RS24100 ENOG4105CHY citrate lyase, alpha F7D04_RS24105 ENOG4105CI0 Citrate lyase F7D04_RS24115 ENOG4105DUA (citrate (pro-3S)-lyase ligase F7D04_RS24120 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F7D04_RS24125 ENOG4106YYS transcriptional regulatory protein F7D04_RS24130 ENOG4105CEE C4-dicarboxylate transporter F7D04_RS24135 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) F7D04_RS24155 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) F7D04_RS24165 ENOG41064T2 transcriptional regulator, lysR family F7D04_RS24180 ENOG4105DZ1 carboxypeptidase F7D04_RS24185 ENOG4105K6T rare lipoprotein A F7D04_RS24190 ENOG4105CNI cell division protein FtsW F7D04_RS24195 ENOG4105CJN penicillin-binding protein F7D04_RS24205 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) F7D04_RS24210 ENOG4108TGR phosphatase F7D04_RS24220 ENOG4105DJF DNA polymerase III, delta' subunit F7D04_RS24235 ENOG4107PAI alpha helical protein F7D04_RS24240 ENOG4105EUU Sel1 domain protein repeat-containing protein F7D04_RS24245 ENOG41069CF Protein of unknown function (DUF1266) F7D04_RS24250 ENOG4105QFC Hsc56 co-chaperone of HscC F7D04_RS24255 ENOG4107JFD Sel1 repeat F7D04_RS24260 ENOG41069CF Protein of unknown function (DUF1266) F7D04_RS24265 ENOG4105QFC Hsc56 co-chaperone of HscC F7D04_RS24270 ENOG4105F7F Chaperone F7D04_RS24280 ENOG4105CDA abc transporter atp-binding protein F7D04_RS24285 ENOG4105DRP amino acid AbC transporter F7D04_RS24290 ENOG4105EAD ABC transporter F7D04_RS24295 ENOG4107RP9 extracellular solute-binding protein, family 3 F7D04_RS24305 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) F7D04_RS24310 ENOG4108JU5 Magnesium and cobalt efflux protein F7D04_RS24320 ENOG4105C9A Phoh family F7D04_RS24330 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F7D04_RS24375 ENOG4105CAQ asparagine synthetase F7D04_RS24380 ENOG4105D4U had-superfamily hydrolase, subfamily iia F7D04_RS24385 ENOG4105E2R ROK family F7D04_RS24390 ENOG4105CE4 GlcNAc 6-P deacetylase F7D04_RS24400 ENOG4105CI1 PTS System F7D04_RS24415 ENOG4105GX6 (LipO)protein F7D04_RS24420 ENOG41090R7 Ferric uptake F7D04_RS24430 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) F7D04_RS24435 ENOG4105NNH LexA regulated protein F7D04_RS24440 ENOG4105EV9 Alpha Beta Hydrolase F7D04_RS24445 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) F7D04_RS24450 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 F7D04_RS24455 ENOG4105D5Q Arginine ornithine antiporter F7D04_RS24460 ENOG4105CXN decarboxylase F7D04_RS24470 ENOG4105EEX Two component transcriptional regulator (Winged helix family F7D04_RS24475 ENOG4105C08 Histidine kinase F7D04_RS24500 ENOG4105XIQ Protein of unknown function (DUF2517) F7D04_RS24505 ENOG4105CNA YD repeat protein F7D04_RS24510 ENOG4106R09 F7D04_RS24525 ENOG4107SEY Conserved Protein F7D04_RS24530 ENOG4105CVP deoxyribo-dipyrimidine photolyase F7D04_RS24535 ENOG4105DUX Transporter F7D04_RS24540 ENOG4107QNR UPF0135 protein F7D04_RS24545 ENOG4105P4J Allophanate hydrolase, subunit 1 F7D04_RS24550 ENOG4107R7A Allophanate hydrolase subunit 2 F7D04_RS24565 ENOG4108KK1 membrane protein AbrB duplication F7D04_RS24570 ENOG4108MY7 Fimbrial F7D04_RS24575 ENOG4108TTM chaperone F7D04_RS24580 ENOG4106PG1 outer membrane usher protein F7D04_RS24585 ENOG4106UBK fimbrial-like adhesin protein F7D04_RS24590 ENOG4105BZN citrate synthase F7D04_RS24600 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit F7D04_RS24605 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein F7D04_RS24610 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) F7D04_RS24615 ENOG4105E33 succinate dehydrogenase F7D04_RS24620 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F7D04_RS24625 ENOG4105C7S Dehydrogenase F7D04_RS24635 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F7D04_RS24640 ENOG4105FDP GntR family transcriptional regulator F7D04_RS24645 ENOG4105DM4 PTS System F7D04_RS24650 ENOG4105C8I hydrolase, family 38 F7D04_RS24655 ENOG4105C4M (Ubiquinol oxidase) subunit I F7D04_RS24660 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F7D04_RS24670 ENOG4105KJB cyd operon protein YbgE F7D04_RS24675 ENOG4107YD3 Thioesterase F7D04_RS24680 ENOG4105E02 MotA TolQ exbB proton channel F7D04_RS24690 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA F7D04_RS24700 ENOG4105KCK Peptidoglycan-associated lipoprotein F7D04_RS24705 ENOG4105UFD tol-pal system protein YbgF F7D04_RS24745 ENOG4106Z1T Nicotinamide Mononucleotide Transporter F7D04_RS24750 ENOG4105PGM cation diffusion facilitator family transporter F7D04_RS24755 ENOG4105JND homeobox protein F7D04_RS24760 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F7D04_RS24770 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) F7D04_RS24780 ENOG4105F0Z galactose-1-phosphate uridylyltransferase F7D04_RS24785 ENOG4105CMR udp-glucose 4-epimerase F7D04_RS24790 ENOG4105DKW ABC transporter F7D04_RS24795 ENOG4105F4R Transcriptional regulator mode F7D04_RS24805 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F7D04_RS24810 ENOG4105E0C molybdate abc transporter F7D04_RS24820 ENOG4108K4B hydrolase F7D04_RS24830 ENOG4105F04 LysR family Transcriptional regulator F7D04_RS24835 ENOG4105C7F AcnD-accessory protein PrpF F7D04_RS24840 ENOG4107QPK )-transporter F7D04_RS24845 ENOG4107QM5 aconitate hydratase F7D04_RS24850 ENOG4105NBR Pectinesterase F7D04_RS24855 ENOG4108V1U phospholipid-binding protein F7D04_RS24860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F7D04_RS24870 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F7D04_RS24875 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F7D04_RS24880 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F7D04_RS24890 ENOG4105CHW UPF0052 protein F7D04_RS24900 ENOG4108RIR Molybdenum cofactor biosynthesis protein F7D04_RS24910 ENOG4105M00 molybdopterin converting factor, subunit 1 F7D04_RS24915 ENOG4108ZAF Molybdopterin F7D04_RS24920 ENOG4105HFZ Membrane F7D04_RS24925 ENOG410733J conserved inner membrane protein F7D04_RS24930 ENOG4107UXM Membrane F7D04_RS24935 ENOG4105DZQ phospholipase D Transphosphatidylase F7D04_RS24940 ENOG4105X23 Endonuclease Exonuclease phosphatase F7D04_RS24945 ENOG4105I9U inner membrane protein ybhQ F7D04_RS24950 ENOG4107QWP ABC-2 type transporter F7D04_RS24955 ENOG4107QWP ABC-2 type transporter F7D04_RS24960 ENOG4105CJ1 ABC, transporter F7D04_RS24970 ENOG4107MVR Transcriptional regulator F7D04_RS24975 ENOG4105C1J atp-dependent rna helicase F7D04_RS24980 ENOG4108UV1 cellular component movement F7D04_RS24985 ENOG4105DVT helicase F7D04_RS24990 ENOG4108MTB glycosyl transferase family F7D04_RS24995 ENOG4105DG4 malate L-lactate dehydrogenase F7D04_RS25000 ENOG4105VR4 UPF0379 protein ybiJ F7D04_RS25005 ENOG4105KSC Transcriptional regulator, TraR DksA family F7D04_RS25015 ENOG4108IU3 tonb-dependent siderophore receptor F7D04_RS25020 ENOG4105ZY9 UPF0379 protein ybiM F7D04_RS25030 ENOG4105D8X mechanosensitive ion channel F7D04_RS25035 ENOG4105CDA abc transporter atp-binding protein F7D04_RS25040 ENOG4105E5Q amino acid AbC transporter F7D04_RS25045 ENOG4107R0W ABC transporter F7D04_RS25055 ENOG4107AQZ Membrane F7D04_RS25065 ENOG4108T1M outer membrane protein x F7D04_RS25070 ENOG4108I6E Sulfatase F7D04_RS25080 ENOG4105KST dependent repressor F7D04_RS25085 ENOG4105F4P )-transporter F7D04_RS25090 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F7D04_RS25095 ENOG4105C5H ABC transporter F7D04_RS25105 ENOG41072TH Protein of unknown function (DUF1479) F7D04_RS25110 ENOG4108HCJ Hydrolase F7D04_RS25120 ENOG4105F1A Pyruvate formate-lyase F7D04_RS25125 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F7D04_RS25130 ENOG4105D06 uba thif-type nad fad binding protein F7D04_RS25135 ENOG4105CVM Molybdenum cofactor synthesis domain protein F7D04_RS25140 ENOG4105D44 asparaginase F7D04_RS25165 ENOG4105BZU Histidine kinase F7D04_RS25170 ENOG41064RH membrane protein YliF F7D04_RS25180 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway F7D04_RS25185 ENOG4105D8V Glucose sorbosone dehydrogenase F7D04_RS25190 ENOG4108TGY Glutathione S-transferase F7D04_RS25195 ENOG4105DZ1 carboxypeptidase F7D04_RS25200 ENOG4107FB0 transcriptional regulator DeoR family F7D04_RS25205 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F7D04_RS25210 ENOG4107QF7 multi-drug F7D04_RS25220 ENOG4108HCJ Hydrolase F7D04_RS25225 ENOG4106UW1 Major Facilitator superfamily F7D04_RS25230 ENOG4108RFG Tetr family transcriptional regulator F7D04_RS25240 ENOG4105GWF inner membrane protein YbjM F7D04_RS25245 ENOG41090BQ Glutaredoxin F7D04_RS25250 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress F7D04_RS25255 ENOG4108DBC nitroreductase F7D04_RS25265 ENOG4108RMJ sensory transduction regulator F7D04_RS25270 ENOG4107RUE extracellular solute-binding protein family 1 F7D04_RS25275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F7D04_RS25280 ENOG4105F38 ABC transporter, permease F7D04_RS25285 ENOG4105D38 putrescine abc transporter F7D04_RS25290 ENOG4105RBQ inner membrane protein ybjO F7D04_RS25300 ENOG4106TNF Periplasmic binding protein F7D04_RS25305 ENOG4105DMR ABC, transporter F7D04_RS25310 ENOG4105GBT ABC transporter F7D04_RS25315 ENOG4106PMH Extracellular solute-binding protein family 3 F7D04_RS25320 ENOG4105E5Z arginine transporter ATP-binding subunit F7D04_RS25325 ENOG41064MM (LipO)protein F7D04_RS25335 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F7D04_RS25340 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F7D04_RS25345 ENOG4105CGD Nad-dependent epimerase dehydratase F7D04_RS25350 ENOG4105C5W Aldolase F7D04_RS25355 ENOG4105C7K acetolactate synthase F7D04_RS25360 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F7D04_RS25370 ENOG4105DWU Membrane F7D04_RS25375 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F7D04_RS25380 ENOG4105CPB ATP-dependent endonuclease of the OLD family F7D04_RS25385 ENOG4108MJ5 VirK protein F7D04_RS25390 ENOG4105DJY efflux transporter, rnd family, mfp subunit F7D04_RS25395 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F7D04_RS25400 ENOG4105VEQ Cold shock protein F7D04_RS25410 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F7D04_RS25430 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) F7D04_RS25440 ENOG4108JJ8 (ABC) transporter F7D04_RS25445 ENOG4108JJ9 ABC, transporter F7D04_RS25450 ENOG4105C3M thioredoxin reductase F7D04_RS25460 ENOG4105CNU cell division protein FtsK F7D04_RS25470 ENOG4105D1H recombination factor protein RarA F7D04_RS25480 ENOG4107QY8 reductase F7D04_RS25485 ENOG4105QAX Iron-sulfur F7D04_RS25490 ENOG4107KGK dmso reductase anchor subunit F7D04_RS25495 ENOG4105CHJ isochorismatase hydrolase F7D04_RS25505 ENOG4105E5D amino acid F7D04_RS25510 ENOG410642W LysR family Transcriptional regulator F7D04_RS25515 ENOG4108X0B nad(p)h dehydrogenase (quinone) F7D04_RS25520 ENOG4105F1A Pyruvate formate-lyase F7D04_RS25525 ENOG4105C6N Formate acetyltransferase F7D04_RS25530 ENOG4105TMB Formate nitrite transporter F7D04_RS25535 ENOG4105DDY UPF0142 protein ycaO F7D04_RS25540 ENOG4107VMU Membrane F7D04_RS25555 ENOG4108K0D peptidase, M48 F7D04_RS25565 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) F7D04_RS25575 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 F7D04_RS25580 ENOG4105BZ1 (ABC) transporter F7D04_RS25590 ENOG4105T0Z Conserved Protein F7D04_RS25605 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups F7D04_RS25610 ENOG4107S90 membrAne F7D04_RS25615 ENOG4106371 Methyltransferase F7D04_RS25625 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) F7D04_RS25630 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) F7D04_RS25635 ENOG4105DIT ErfK YbiS YcfS YnhG family protein F7D04_RS25640 ENOG4105EAQ (twin-arginine translocation) pathway signal F7D04_RS25645 ENOG4105C5X domain protein F7D04_RS25650 ENOG4105CGF Aromatic amino acid aminotransferase F7D04_RS25655 ENOG4105FCK Membrane F7D04_RS25670 ENOG4105CD8 aminopeptidase N F7D04_RS25680 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F7D04_RS25690 ENOG4105GVF (ABC) transporter F7D04_RS25695 ENOG4108UZX fmn reductase F7D04_RS25700 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon F7D04_RS25705 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae F7D04_RS25710 ENOG4105CW0 outer membrane usher protein F7D04_RS25715 ENOG4108MDY Fimbrial F7D04_RS25720 ENOG4105Q7J Fimbrial F7D04_RS25725 ENOG4105MX3 Fimbrial F7D04_RS25740 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) F7D04_RS25745 ENOG4105QVC MOSC domain-containing protein F7D04_RS25755 ENOG4105C5H ABC transporter F7D04_RS25760 ENOG4105F1S paraquat-inducible protein a F7D04_RS25765 ENOG4105DY2 Paraquat-inducible protein b F7D04_RS25770 ENOG4108Q2G (LipO)protein F7D04_RS25775 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) F7D04_RS25785 ENOG4105DAN ATP-dependent protease F7D04_RS25795 ENOG4105UYK outer membrane protein a F7D04_RS25805 ENOG4108RZ1 DNA transformation protein F7D04_RS25810 ENOG4105EM2 membrane F7D04_RS25815 ENOG410901E Membrane F7D04_RS25820 ENOG41088T4 Helicase IV F7D04_RS25835 ENOG4105K4P CoA-binding domain protein F7D04_RS25850 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 F7D04_RS25855 ENOG4108Z0T Part of a sulfur-relay system (By similarity) F7D04_RS25860 ENOG4108MN8 Membrane F7D04_RS25875 ENOG41076J9 exonuclease VIII F7D04_RS25880 ENOG4106G8A Qin prophage F7D04_RS25925 ENOG41087BU transcriptional repressor DicA F7D04_RS26005 ENOG4108MXB Protein of unknown function (DUF968) F7D04_RS26010 ENOG4105KSK (crossover) junction endodeoxyribonuclease F7D04_RS26015 ENOG4105HRS Antitermination protein F7D04_RS26065 ENOG4105UZW Tail fiber assembly protein F7D04_RS26070 ENOG4107DE1 head-to-tail joining protein F7D04_RS26090 ENOG4105IM0 capsid protein F7D04_RS26195 ENOG4105D05 Receptor F7D04_RS26235 ENOG4105D70 Integrase catalytic subunit F7D04_RS26280 ENOG4105D70 Integrase catalytic subunit F7D04_RS26360 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A F7D04_RS26380 ENOG4107U2T alpha beta F7D04_RS26385 ENOG4107CBI conjugal transfer fertility inhibition protein F7D04_RS26395 ENOG4105KK6 nuclease F7D04_RS26410 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) F7D04_RS26420 ENOG4106CQM replication F7D04_RS26435 ENOG4105EQR Transposase IS116 IS110 IS902 F7D04_RS26495 ENOG4108RC6 RTX toxin F7D04_RS26500 ENOG4107V48 Hemolysin-type calcium-binding F7D04_RS26505 ENOG4108JJA ABC, transporter F7D04_RS26510 ENOG4105C42 Type I secretion membrane fusion protein (HlyD F7D04_RS26525 ENOG4105EKQ RNA-directed DNA polymerase F7D04_RS26580 ENOG4105DDI hemolysin-type calcium-binding region F7D04_RS26615 ENOG4105DWP Membrane F7D04_RS26660 ENOG4105E5H Transposase F7D04_RS26665 ENOG4108YXQ IS66 Orf2 family protein F7D04_RS26755 ENOG4108YXQ IS66 Orf2 family protein F7D04_RS26780 ENOG4105I1J Autotransporter F7D04_RS26805 ENOG4105EKQ RNA-directed DNA polymerase F7D04_RS26900 ENOG4105H3G oxidoreductase